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Sample records for degli urologi lombardi

  1. [Urological emergencies].

    Science.gov (United States)

    Danuser, H; Ackermann, D K; Studer, U E

    1993-04-17

    Every general practitioner has to deal with urologic emergencies. The most frequent illnesses are urinary retention, acute scrotum, priapism, macrohematuria, nephritic colic, obstructive pyelonephritis and pyonephrosis. Whereas urinary retention, as well as acute ureteric stone colic must generally be treated by the practitioner, the urologist must often be consulted in case of an acute scrotum or for priapism. Testicular torsion is one situation, where surgical treatment needs to be performed within 6 hours. Of utmost importance is his timely assistance with the obstructive pyelonephritis and pyonephrosis. These are initially often not recognized, especially because the first ultrasound examination of the intrarenal pyelone may not show a dilatation of the collecting system despite obstruction. If the adequate treatment with drainage and antibiotics is applied too late, this can result in serious and potentially lethal consequences.

  2. The future of urology.

    Science.gov (United States)

    Abrams, Paul; Brausi, Maurizio; Buntrock, Stefan; Ebert, Thomas; Hashim, Hashim; Tiselius, Hans-Göran; Wyndaele, Jean-Jacques

    2012-03-01

    The Future of Urology has been written in times of economic downturn, with the inevitable effects on health sector spending. Nevertheless, this document aims to define a path whereby the EAU can play a pivotal role in ensuring the highest standard of care throughout Europe, and by setting standards, throughout the rest of the world. The future of urology will be dependent on improved education and training leading to high quality urological care, and to developing a service that is patient focused. The patient focus is becoming increasingly important in urology. This means providing full information about disease processes and urological procedures to patients and allowing them to judge the quality of the urological service that they may choose. Education must start in medical school and as 5% of community medical practice is urology then every medical student must receive urological training. This also applies to nurses and the other professions allied to medicine (PAMS). The EAU should provide a urological curriculum for training of medical students, nurses and PAMS, as well as the more conventional curriculum for postgraduate training and continued medical education for urological specialists. An integrated EAU Knowledge and Learning Centre would provide an invaluable resource to patients and to those who deliver urologic care alike. With high quality training must come a vigorous assessment of knowledge and competence. In the future, the competence of all those delivering urological care will need to be assessed. For urologists in training and specialist urologists this will include not only an assessment of knowledge but an assessment of surgical competence. Improving quality will be supported by the continued subspecialisation of urology, ensuring that all urologists have a surgical portfolio which ensures their competency in the procedures they deliver. This will inevitably result in a concentration of urological services and indeed to the development of

  3. I caratteri tipicizzanti il paesaggio dei grandi laghi lombardi

    Directory of Open Access Journals (Sweden)

    Roberto Busi

    2013-01-01

    Full Text Available I sei grandi laghi lombardi costituiscono un distretto, posto tra l’alta pianura del Po e le Alpi, con spiccate caratteristiche paesistiche. L’ambiente fisico e biologico (ed, in particolare, la vegetazione e l’opera plurisecolare dell’uomo hanno infatti connotato il territorio con componenti la cui organica giustapposizione manifesta paesaggi che, ad un tempo, hanno forte unitarietà territoriale e spinta individualità. I grandi laghi lombardi costituiscono pertanto un importante patrimonio culturale e paesaggistico che necessita, per la sua conservazione e valorizzazione, di adeguata attenzione e sensibilità.

  4. Advanced urology nursing practice.

    Science.gov (United States)

    Crowe, Helen

    2014-03-01

    Urology nursing has developed as a specialty over the past few decades in response to several factors, workload demands being a prime reason. Nurses are taking on additional roles and activities including procedures such as cystoscopy and prostate biopsy, and running nurse-led clinics for a variety of urological conditions. Audits of advanced urological nursing practice have shown this care to be of a high standard and investigative procedures performed by these nurses match the diagnostic quality of existing services. Professional urological nursing organizations support the professional needs of these nurses, but the provision of education and training for advanced practice activities remains an unaddressed need. A range of confusing advanced urology nursing titles exists, and uncertainty regarding the roles and scope of practice for these nurses remains a concern. Acceptance and support from medical colleagues is required for the success of advanced urological nursing practice, but opinions on these roles remain divided.

  5. Career development resource: urology.

    Science.gov (United States)

    Gormley, E Ann

    2012-07-01

    Urology has always been seen as being on the cutting edge of technology and this has been especially prevalent in the past 10 to 15 years with a move to robotic surgery, increased use of laser technology, and stem cell research leading to organ regeneration. Urology has a number of subspecialties including pediatrics, urologic oncology, renal transplantation, male infertility and andrology, calculi, female urology, neurourology, and trauma and reconstruction. Urologists have a wide array of practice options ranging from performing major oncologic procedures with extensive reconstruction to having an office-based practice and performing endoscopic cases with everything else in between. Subspecialization is becoming increasingly more organized and regulated.

  6. 78 FR 63997 - Kidney, Urologic, and Hematologic Diseases Interagency Coordinating Committee; Urology...

    Science.gov (United States)

    2013-10-25

    ... Coordinating Committee; Urology Subcommittee Workshop SUMMARY: The Urology Subcommittee of the Kidney, Urologic...--Urology Subcommittee, National Institute of Diabetes and Digestive and Kidney Diseases, 6707 Democracy..., workshop held by the KUHICC Urology Subcommittee, also called the ``Urology Interagency...

  7. Evolution of urological imaging.

    Science.gov (United States)

    Bueschen, Anton J; Lockhart, Mark E

    2011-02-01

    The evolution of urological imaging has had a major impact on the diagnosis and treatment of urological diseases since the discovery of the X-ray by Roentgen in 1895. Early developments included plain films of the abdomen, retrograde urographic techniques, development of contrast media, excretory urography, renal mass puncture, renal angiography, cystography and nuclear medicine procedures. These procedures led to the maturation of the specialties of diagnostic radiology and urology, and the development of the subspecialties of pediatric urology and urological radiology during the first seven decades of the 20th century. Subsequently, many imaging advances have occurred leading to changes in diagnosis and management of urological patients. Ultrasound and cross-sectional imaging technologies (computed tomography and magnetic resonance imaging) are increasingly applied in urological evaluation, treatment and surveillance. Current developments include dual energy computed tomography, positron emission tomography computed tomography, renal donor and renal transplant imaging, prostate magnetic resonance imaging, and microbubble contrast enhanced ultrasound. Imaging advances will continue. It is the responsibility of all physicians to assess the advantages of new developments while weighing those advantages against the additional radiation exposure and the costs associated with new procedures.

  8. Nanotechnology in Urology

    Science.gov (United States)

    Jayasimha, Sudhindra

    2017-01-01

    Introduction: Nanotechnology has revolutionized our approach to medical diagnostics as well as therapeutics and has spanned an entirely new branch of research. This review addresses the potential applications of Nanotechnology in Urology. This article is based on the Dr. Sitharaman Best Essay award of the Urological Society of India for 2016. Methods: A PubMed search was performed for all relevant articles using the terms, “nanotechnology, nanoparticles, nanoshells, nanoscaffolds, and nanofibers.” Results: The developments in diagnostics include novel techniques of imaging of genitourinary malignancies, prostate-specific antigen measurement, early detection of mutations that are diagnostic for polycystic kidney disease. The potential applications of nanotechnology are in the targeted therapy of genitourinary malignancies, erectile dysfunction, overactive bladder, bladder reconstruction, construction of artificial kidneys and biodegradable stents as well as in robotic surgery. Conclusions: Nanotechnology is a rapidly emerging branch of research in urology with diverse and clinically significant applications in diagnostics as well as therapeutics. PMID:28197024

  9. Prevention of urological cancer

    Directory of Open Access Journals (Sweden)

    M S Ansari

    2003-01-01

    Full Text Available Objectives: Many urological cancers like prostate and bladder have protracted course and maybe ideal for chemoprevention strategies. This article reviews the biol-ogy, epidemiology and possible preventive strategies for the various urological cancers. Methods: The author reviewed the relevant articles published in the last 20 years and studied the biology of the various urological cancers. An attempt is made to identify the various dietary, nutritional and occupation-related factors implicated in the onset and progression of various urological cancers. The various interventions and clinical trial results are described to prove the relevance of these factors. Results: Epidemiological reports provide the strongest evidence of protective role for dietary agents in cancer of prostate, bladder and kidney. Cancers of prostate and blad-der are uniquely suitable for chemopreventive strategies. For prostate cancer strong evidence exists for a preven-tive effect of reduced fat intake, vitamin E, selenium, lycopene and soya proteins. Vitamin A administration shows a strong inverse relation to bladder cancer. Better prevention is seen with combination of high doses of vita-mins A, C, E and B6. High-energy intake is related to the higher incidence of renal cell carcinoma (RCC. While vitamins D and E supplementation has resulted in lower incidence of RCC. Conclusions: Numerous studies implicate dietary and nutritional factors in the onset and progression of various urological cancers. Hence, it is possible that bioactive compounds (anti-oxidants like vits. A, D, C, and E, min-erals like selenium and carotenoids like lycopene along with reduction of animal fat in diet can be a part of pre-ventive strategies for various urological cancers.

  10. Pheochromocytoma in Urologic Practice

    Science.gov (United States)

    Waingankar, Nikhil; Bratslavsky, Gennady; Jimenez, Camilo; Russo, Paul; Kutikov, Alexander

    2016-01-01

    Context Pheochromocytoma is regularly encountered in urological practice and requires a thoughtful and careful clinical approach. Objective To review clinical aspects of management of pheochromocytoma in urologic practice. Evidence Acquisition A systematic review of English-language literature was performed through year 2015 using the Medline database. Manuscripts were selected with consensus of the coauthors and evaluated using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) criteria. Evidence Synthesis Findings and recommendations of the evaluated manuscripts are discussed with an emphasis on the description of presentation, diagnosis, evaluation, and perioperative care. Conclusion In addition to surgical expertise, appropriate management of pheochromocytoma in urologic practice requires nuanced understanding of pathophysiology, genetics, and endocrinological principles. When skillfully managed, the vast majority of patients with pheochromocytoma should expect an excellent prognosis. Patient Summary In this article we review the clinical approach to patients with pheochromocytoma, a tumor that stems from the innermost part of the adrenal gland and that often secretes excessive amounts of powerful hormones such as noradrenaline and adrenaline. Significant expertise is required to appropriately manage patients with these tumors. Take Home Message In addition to surgical expertise, appropriate management of pheochromocytoma in urologic practice requires nuanced understanding of pathophysiology, genetics, and endocrinological principles. When skillfully managed, vast majority of patients with pheochromocytoma should expect an excellent prognosis. PMID:28078330

  11. FDG in Urologic Malignancies

    DEFF Research Database (Denmark)

    Høilund-Carlsen, Poul Flemming; Poulsen, Mads Hvid; Petersen, Henrik;

    2014-01-01

    F-fluoro-deoxy-glucose (FDG). PET imaging has been applied more often in prostate cancer. FDG-PET/CT is claimed to have a high frequency of false-negative results in urologic cancers; however, this finding may instead reflect correctly the state of disease being due to slow-growing cancers...

  12. Urologic Issues During Pregnancy

    Directory of Open Access Journals (Sweden)

    Jeffrey P. Weiss

    2004-01-01

    Full Text Available Pregnancy induces a variety of physiologic changes in the urinary tract. When such changes become accentuated the physiologic becomes the pathologic and symptoms arise, at times of significance enough to threaten the well being of mother and/or fetus. This article intends to describe the basis for urinary physiology and its pathologic counterparts during pregnancy. Such a background may then facilitate a rational management protocol for various urologic problems in the gravid state.

  13. The laser in urology

    Science.gov (United States)

    Hofstetter, Alfons G.

    2002-10-01

    Laser is an acronym for a physical principle and means: Light Amplification by stimulated Emission of Radiation. This principle offers a lot of tissue/light effects caused by the parameters: power density/time and the special qualities of the laser light. Nowadays for diagnosis and therapy following lasers are used in urology: Krypton- and Dye-lasers as well as the Neodymium-YAG- (nd:YAG-), Holmium-YAG (Ho:YAG-), Diode-, Argon- and the CO2-lasers.

  14. Wound healing in urology.

    Science.gov (United States)

    Ninan, Neethu; Thomas, Sabu; Grohens, Yves

    2015-03-01

    Wound healing is a dynamic and complex phenomenon of replacing devitalized tissues in the body. Urethral healing takes place in four phases namely inflammation, proliferation, maturation and remodelling, similar to dermal healing. However, the duration of each phase of wound healing in urology is extended for a longer period when compared to that of dermatology. An ideal wound dressing material removes exudate, creates a moist environment, offers protection from foreign substances and promotes tissue regeneration. A single wound dressing material shall not be sufficient to treat all kinds of wounds as each wound is distinct. This review includes the recent attempts to explore the hidden potential of growth factors, stem cells, siRNA, miRNA and drugs for promoting wound healing in urology. The review also discusses the different technologies used in hospitals to treat wounds in urology, which make use of innovative biomaterials synthesised in regenerative medicines like hydrogels, hydrocolloids, foams, films etc., incorporated with growth factors, drug molecules or nanoparticles. These include surgical zippers, laser tissue welding, negative pressure wound therapy, and hyperbaric oxygen treatment.

  15. Met in Urological Cancers

    Energy Technology Data Exchange (ETDEWEB)

    Miyata, Yasuyoshi, E-mail: int.doc.miya@m3.dion.ne.jp; Asai, Akihiro; Mitsunari, Kensuke; Matsuo, Tomohiro; Ohba, Kojiro; Mochizuki, Yasushi; Sakai, Hideki [Department of Urology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501 (Japan)

    2014-12-16

    Met is a tyrosine kinase receptor that is considered to be a proto-oncogene. The hepatocyte growth factor (HGF)-Met signaling system plays an important role in tumor growth, invasion, and metastasis in many types of malignancies. Furthermore, Met expression has been reported to be a useful predictive biomarker for disease progression and patient survival in these malignancies. Many studies have focused on the clinical significance and prognostic role of Met in urological cancers, including prostate cancer (PCa), renal cell carcinoma (RCC), and urothelial cancer. Several preclinical studies and clinical trials are in progress. In this review, the current understanding of the pathological role of Met in cancer cell lines, its clinical significance in cancer tissues, and its predictive value in patients with urological cancers are summarized. In particular, Met-related malignant behavior in castration-resistant PCa and the different pathological roles Met plays in papillary RCC and other histological types of RCC are the subjects of focus. In addition, the pathological significance of phosphorylated Met in these cancers is shown. In recent years, Met has been recognized as a potential therapeutic target in various types of cancer; therapeutic strategies used by Met-targeted agents in urological cancers are summarized in this review.

  16. Il teatro degli spiriti.

    Directory of Open Access Journals (Sweden)

    Chiara Pussetti

    2013-07-01

    Full Text Available Questo saggio è dedicato a un culto di possessione, in cui tutte ledonne, investite dagli spiriti degli uomini morti prima dell’iniziazione, compiono un percorso iniziatico parallelo a quello maschile, consentendo a queste anime, potenzialmente pericolose, di completare il cammino che non hanno potuto percorrere da vivi e quindi di raggiungere serenamente il mondo dei morti, come antenati protettori del villaggio

  17. Integration of natural and technological risks in Lombardy, Italy

    Science.gov (United States)

    Lari, S.; Frattini, P.; Crosta, G. B.

    2009-12-01

    Multi-risk assessment is becoming a valuable tool for land planning, emergency management and the deployment of mitigation strategies. Multi-risk maps combine all available information about hazard, vulnerability, and exposed values related to different dangerous phenomena, and provide a quantitative support to complex decision making. We analyse and integrate through an indicator-based approach nine major threats affecting the Lombardy Region (Northern Italy, 25 000 km2), namely landslide, avalanche, flood, wildfire, seismic, meteorological, industrial (technological) risks; road accidents, and work injuries. For each threat, we develop a set of indicators that express the physical risk and the coping capacity or system resilience. By combining these indicators through different weighting strategies (i.e. budgetary allocation, and fuzzy logic), we calculate a total risk for each threat. Then, we integrate these risks by applying AHP (Analytic Hierarchy Process) weighting, and we derive a set of multi-risk maps. Eventually, we identify the dominant risks for each zone, and a number of risk hot-spot areas. The proposed approach can be applied with different degree of detail depending on the quality of the available data. This allows the application of the method even in case of non homogeneous data, which is often the case for regional scale analyses. Moreover, it allows the integration of different risk types or metrics. Relative risk scores are provided from this methodology, not directly accounting for the temporal occurrence probability of the phenomena.

  18. Diabetes and Sexual and Urologic Problems

    Science.gov (United States)

    ... Other Dental Problems Diabetes & Sexual & Urologic Problems Diabetes & Sexual & Urologic Problems Troublesome bladder symptoms and changes in ... of these sexual and urologic problems. Diabetes and Sexual Problems Both men and women with diabetes can ...

  19. Stem cells in urology.

    Science.gov (United States)

    Aboushwareb, Tamer; Atala, Anthony

    2008-11-01

    The shortage of donors for organ transplantation has stimulated research on stem cells as a potential resource for cell-based therapy in all human tissues. Stem cells have been used for regenerative medicine applications in many organ systems, including the genitourinary system. The potential applications for stem cell therapy have, however, been restricted by the ethical issues associated with embryonic stem cell research. Instead, scientists have explored other cell sources, including progenitor and stem cells derived from adult tissues and stem cells derived from the amniotic fluid and placenta. In addition, novel techniques for generating stem cells in the laboratory are being developed. These techniques include somatic cell nuclear transfer, in which the nucleus of an adult somatic cell is placed into an oocyte, and reprogramming of adult cells to induce stem-cell-like behavior. Such techniques are now being used in tissue engineering applications, and some of the most successful experiments have been in the field of urology. Techniques to regenerate bladder tissue have reached the clinic, and exciting progress is being made in other areas, such as regeneration of the kidney and urethra. Cell therapy as a treatment for incontinence and infertility might soon become a reality. Physicians should be optimistic that regenerative medicine and tissue engineering will one day provide mainstream treatment options for urologic disorders.

  20. Predictive models in urology.

    Science.gov (United States)

    Cestari, Andrea

    2013-01-01

    Predictive modeling is emerging as an important knowledge-based technology in healthcare. The interest in the use of predictive modeling reflects advances on different fronts such as the availability of health information from increasingly complex databases and electronic health records, a better understanding of causal or statistical predictors of health, disease processes and multifactorial models of ill-health and developments in nonlinear computer models using artificial intelligence or neural networks. These new computer-based forms of modeling are increasingly able to establish technical credibility in clinical contexts. The current state of knowledge is still quite young in understanding the likely future direction of how this so-called 'machine intelligence' will evolve and therefore how current relatively sophisticated predictive models will evolve in response to improvements in technology, which is advancing along a wide front. Predictive models in urology are gaining progressive popularity not only for academic and scientific purposes but also into the clinical practice with the introduction of several nomograms dealing with the main fields of onco-urology.

  1. Integration of natural and technological risks in Lombardy, Italy

    Directory of Open Access Journals (Sweden)

    S. Lari

    2009-12-01

    Full Text Available Multi-risk assessment is becoming a valuable tool for land planning, emergency management and the deployment of mitigation strategies. Multi-risk maps combine all available information about hazard, vulnerability, and exposed values related to different dangerous phenomena, and provide a quantitative support to complex decision making.

    We analyse and integrate through an indicator-based approach nine major threats affecting the Lombardy Region (Northern Italy, 25 000 km2, namely landslide, avalanche, flood, wildfire, seismic, meteorological, industrial (technological risks; road accidents, and work injuries. For each threat, we develop a set of indicators that express the physical risk and the coping capacity or system resilience. By combining these indicators through different weighting strategies (i.e. budgetary allocation, and fuzzy logic, we calculate a total risk for each threat. Then, we integrate these risks by applying AHP (Analytic Hierarchy Process weighting, and we derive a set of multi-risk maps. Eventually, we identify the dominant risks for each zone, and a number of risk hot-spot areas.

    The proposed approach can be applied with different degree of detail depending on the quality of the available data. This allows the application of the method even in case of non homogeneous data, which is often the case for regional scale analyses. Moreover, it allows the integration of different risk types or metrics.

    Relative risk scores are provided from this methodology, not directly accounting for the temporal occurrence probability of the phenomena.

  2. Ingegneria degli acquiferi

    CERN Document Server

    Molfetta, Antonio

    2012-01-01

    Il testo fornisce le conoscenze necessarie per affrontare, con un approccio quantitativo, i molteplici aspetti connessi al flusso delle risorse idriche sotterranee (acque di falda) e alla propagazione e bonifica di contaminanti nei sistemi acquiferi. Vengono illustrate le proprietà fondamentali che definiscono la capacità di immagazzinamento, trasporto e rilascio dell’acqua negli acquiferi, e successivamente, descritte le metodiche per la determinazione di tali parametri tramite l’esecuzione e l’interpretazione di prove di falda, di pozzo e di laboratorio. A partire dalla classificazione chimico fisica-tossicologica dei contaminanti vengono, quindi, analizzati i meccanismi di propagazione e illustrate le soluzioni analitiche dell’equazione del trasporto di massa nei mezzi porosi. L’ultima parte del testo è dedicata alla caratterizzazione e bonifica degli acquiferi contaminati. Il testo è rivolto sia agli studenti universitari, sia ai professionisti che debbano affrontare con un approccio quantit...

  3. News on pediatric urology

    Directory of Open Access Journals (Sweden)

    Giuseppe Masnata

    2015-10-01

    Full Text Available Pediatric urology is a pediatric speciality dedicated to the diagnosis and treatment of congenital and acquired genitourinary tract diseases. It is a speciality that is rapidly changing, thanks to the technological development that has been emerging in recent years. There have been important diagnostic and therapeutic news.Congenital anomalies of the kidneys and urinary tract (CAKUT include various entities of structural malformations that result from defects in their morphogenesis. Clinical research and genetic studies on the origins of CAKUT are quickly evolving, with significant growth of high-quality research.Management goals of CAKUT include prevention of febrile urinary tract infections (UTIs in newborns and toddles and renal injury, while minimizing the morbidity of treatment and follow-up. Treatment options include observation with or without continuous antibiotic prophylaxis (CAP and surgical correction. Now, randomized controlled studies show that children with normal urinary tracts or low-grade vesicoureteral reflux (VUR do not benefit from prophylaxis.All children with known mechanical or functional obstructions of the urinary tract are considered to have UTI. Functional obstruction often results from lower urinary tract dysfunction (LUTD of either neurogenic or non-neurogenic origin and dilating VUR.The role of bladder and bowel dysfunction (BBD in children with UTI and the long-term risk of renal scarring have shed new light on treatment strategies. Often it is BBD, rather than reflux, that causes UTI in children older than 2 years.Pediatric urology has evolved in recent years, with a greater focus on bladder and renal function, minimally invasive treatment, evidence-based interventions, and guideline adherence. Other topics in pediatric urology include urinary incontinence in children with special needs and the use of robot-assisted laparoscopic surgery (RALS in children, with advantages over conventional laparoscopic surgery

  4. Forgotten urological stent.

    Science.gov (United States)

    Bhuiyan, Z H; Bhuiyan, N I; Khan, S A; Tawhid, M H; Islam, M F

    2011-10-01

    "Forgotten" Ureteral stent DJ stent related complication is not uncommon even in the era of modern urology in the developed world. In this context we have undertaken a retro-prospective study in relation to its various causes, complications, management and prevention of forgotten stents in a single teaching institute. The study period was from January'04 to December'09. The sample size was 60. The effect of "forgotten stent" in our study reflects mild UTI to various complications including severe renal failure. We had approached all of our cases judiciously using various modalities of minimal access endourological techniques either alone or in combinations with successful outcome. The study concluded that it is vary easy to prevent "forgotten stent" and so its complications. However if we confront such unwanted complications that could be managed successfully with the use of endourological techniques. We did not use other techniques like laparoscopy and open surgery in this study.

  5. Seriousness, preventability, and burden impact of reported adverse drug reactions in Lombardy emergency departments: a retrospective 2-year characterization

    Directory of Open Access Journals (Sweden)

    Perrone V

    2014-12-01

    Full Text Available Valentina Perrone,1,* Valentino Conti,2,* Mauro Venegoni,2 Stefania Scotto,2 Luca Degli Esposti,3 Diego Sangiorgi,3 Lucia Prestini,4 Sonia Radice,1 Emilio Clementi,5,6 Giuseppe Vighi,2,4 1Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital Luigi Sacco, Università di Milano, Milan, Italy; 2Regional Centre for Pharmacovigilance, Lombardy, Milan, Italy; 3CliCon Srl, Health, Economics and Outcomes Research, Ravenna, Italy; 4Unit of Clinical Pharmacology and Pharmacovigilance, Niguarda Ca’Granda Hospital, Milan, Italy; 5Unit of Clinical Pharmacology, CNR Institute of Neuroscience, Department of Biomedical and Clinical Sciences, University Hospital Luigi Sacco, Università di Milano, Milan, Italy; 6Scientific Institute, IRCCS Eugenio Medea, Lecco, Italy *These authors contributed equally to the work Objective: The purpose of this study was to determine the prevalence of adverse drug reactions (ADRs reported in emergency departments (EDs and carry out a thorough characterization of these to assess preventability, seriousness that required hospitalization, subsequent 30-day mortality, and economic burden. Methods: This was a retrospective cohort study of data from an active pharmacovigilance project at 32 EDs in the Lombardy region collected between January 1, 2010 and December 31, 2011. Demographic, clinical, and pharmacological data on patients admitted to EDs were collected by trained and qualified monitors, and deterministic record linkage was performed to estimate hospitalizations. Pharmacoeconomic analyses were based on Diagnosis-Related Group reimbursement. Results: 8,862 ADRs collected with an overall prevalence rate of 3.5 per 1,000 visits. Of all ADRs, 42% were probably/definitely preventable and 46.4% were serious, 15% required hospitalization, and 1.5% resulted in death. The System Organ Classes most frequently associated with ADRs were: skin and subcutaneous tissue, gastrointestinal

  6. Sexual abuse evaluation in urological practice

    NARCIS (Netherlands)

    Beck, Jacobus Johannes Hendrikus

    2013-01-01

    The primary aim of this study is to investigate the prevalence of sexual abuse in a urological outpatient clinic. Can differences been made in urological population, i.e. general urological clinic, a university urological clinic and a tertiary university pelvic floor clinic? Do urologists inquire

  7. Urologic robots and future directions

    OpenAIRE

    Mozer, Pierre; Troccaz, Jocelyne; Stoianovici, Dan

    2008-01-01

    International audience; PURPOSE OF REVIEW: Robot-assisted laparoscopic surgery in urology has gained immense popularity with the daVinci system, but a lot of research teams are working on new robots. The purpose of this study is to review current urologic robots and present future development directions. RECENT FINDINGS: Future systems are expected to advance in two directions: improvements of remote manipulation robots and developments of image-guided robots. SUMMARY: The final goal of robot...

  8. Social housing provision in the Italian region of Lombardy: Between market, state and community

    NARCIS (Netherlands)

    Urbani, S.; Van Bortel, G.A.

    2009-01-01

    This paper describes social housing developments in Lombardy, one of the most affluent regions in the Italy. Housing policy in Italy is mainly the responsibility of the Regions. We discuss the challenges of social housing provision and the interplay between market, state, community and third sector

  9. Social housing provision in the Italian region of Lombardy: Between market, state and community

    NARCIS (Netherlands)

    Urbani, S.; Van Bortel, G.A.

    2009-01-01

    This paper describes social housing developments in Lombardy, one of the most affluent regions in the Italy. Housing policy in Italy is mainly the responsibility of the Regions. We discuss the challenges of social housing provision and the interplay between market, state, community and third sector

  10. Pediatric robotic urologic surgery-2014

    Directory of Open Access Journals (Sweden)

    James T Kearns

    2014-01-01

    Full Text Available We seek to provide a background of the current state of pediatric urologic surgery including a brief history, procedural outcomes, cost considerations, future directions, and the state of robotic surgery in India. Pediatric robotic urology has been shown to be safe and effective in cases ranging from pyeloplasty to bladder augmentation with continent urinary diversion. Complication rates are in line with other methods of performing the same procedures. The cost of robotic surgery continues to decrease, but setting up pediatric robotic urology programs can be costly in terms of both monetary investment and the training of robotic surgeons. The future directions of robot surgery include instrument and system refinements, augmented reality and haptics, and telesurgery. Given the large number of children in India, there is huge potential for growth of pediatric robotic urology in India. Pediatric robotic urologic surgery has been established as safe and effective, and it will be an important tool in the future of pediatric urologic surgery worldwide.

  11. [Doping and urologic tumors].

    Science.gov (United States)

    Pinto, F; Sacco, E; Volpe, A; Gardi, M; Totaro, A; Calarco, A; Racioppi, M; Gulino, G; D'Addessi, A; Bassi, P F

    2010-01-01

    Several substances such as growth hormone (GH), erythropoietin (Epo), and anabolic steroids (AS) are improperly utilized to increase the performance of athletes. Evaluating the potential cancer risk associated with doping agents is difficult since these drugs are often used at very high doses and in combination with other licit or illicit drugs. The GH, via its mediator, the insulin-like growth factor 1 (IGF-1), is involved in the development and progression of cancer. Animal studies suggested that high levels of GH/IGF-1 increase progression of androgen-independent prostate cancer. Clinical data regarding prostate cancer are mostly based on epidemiological studies or indirect data such as IGF-1 high levels in patients with prostate cancer. Even if experimental studies showed a correlation between Epo and cancer, no clinical data are currently available on cancer development related to Epo as a doping agent. Androgens are involved in prostate carcinogenesis modulating genes that regulate cell proliferation, apoptosis and angiogenesis. Most information on AS is anecdotal (case reports on prostate, kidney and testicular cancers). Prospective epidemiologic studies failed to support the hypothesis that circulating androgens are positively associated with prostate cancer risk. Currently, clinical and epidemiological studies supporting association between doping and urological neoplasias are not available. Nowadays, exposure to doping agents starts more prematurely with a consequent longer exposition period; drugs are often used at very high doses and in combination with other licit or illicit drugs. Due to all these elements it is impossible to predict all the side effects, including cancer; more detailed studies are therefore necessary.

  12. Facilities for Territorial Medicine: the experiences of Piedmont and Lombardy Regions

    Directory of Open Access Journals (Sweden)

    Stefano Capolongo

    2015-04-01

    Full Text Available In recent years, the demographic transition and epidemiological has made the health system hospital-centric obsolete and has highlighted the need for a new organization focused on territorial health community, taking charge of the patient, on team work and can ensure, through dedicated facilities, continuity of care and integration of social welfare.The main changes in the regulatory field have thus oriented investments both structural and economic towards poles to network with hospitals that represent new points of reference for the health of citizens, where primary care services are integrated with the territory and the specialized services of the Public Health departments.These facilities provide the organizational paradigm to which the regional realities must strive.The article reports recent experiments conducted within the regions of Piedmont and Lombardy in this sector and the ongoing research in the field of CNETO on behalf of the Lombardy Region.

  13. Nanotechnology applications in urology: a review.

    Science.gov (United States)

    Maddox, Michael; Liu, James; Mandava, Sree Harsha; Callaghan, Cameron; John, Vijay; Lee, Benjamin R

    2014-11-01

    The objectives of this review are to discuss the current literature and summarise some of the promising areas with which nanotechnology may improve urological care. A Medline literature search was performed to elucidate all relevant studies of nanotechnology with specific attention to its application in urology. Urological applications of nanotechnology include its use in medical imaging, gene therapy, drug delivery, and photothermal ablation of tumours. In vitro and animal studies have shown initial encouraging results. Further study of nanotechnology for urological applications is warranted to bridge the gap between preclinical studies and translation into clinical practice, but nanomedicine has shown significant potential to improve urological patient care.

  14. Pediatric urologic emergencies and urgencies.

    Science.gov (United States)

    Leslie, Jeffrey A; Cain, Mark P

    2006-06-01

    The more common urologic problems seen in infancy and childhood that require urgent or emergent pediatric urologic referral are discussed, including a brief description of the usual presenting signs or symptoms, differential diagnoses, proper diagnostic work-up recommended before or at the time of referral, and the usual therapeutic course of management after evaluation by the urologist. These conditions include the acutely swollen scrotum, scrotal masses, penile swelling and erythema, exstrophy, hematuria, urinary retention, abdominal masses, and various genital abnormalities including interlabial masses, hypospadias with any degree of cryptorchidism, and ambiguous genitalia. This article is designed to provide the primary care practitioner with a focused review and a useful resource for managing children who have genitourinary abnormalities in the hospital or clinic setting.

  15. EARLY TORINGIAN SMALL MAMMALS FAUNA FROM FONTANA MARELLA CAVE(VARESE, LOMBARDY, NORTH ITALY

    Directory of Open Access Journals (Sweden)

    FABIO BONA

    2008-03-01

    Full Text Available The Fontana Marella cave, located in the Pre-Alps in Varese province (Lombardy, North Italy, supplied a Middle Pleistocene small mammal fauna, unique for this region.Thanks to the presence of Arvicola cf. mosbachensis and Pliomys episcopalis it is possible to date this sequence to the Early Toringian. Mostly for the predominant, presence of dominant Glis glis, Chionomys nivalis and Dinaromys bogdanovi, the faunal association is attributed to a temperate period,  but cooler and perhaps more arid that the present one. The find of Macroneomys is important because it allows to extend the geographic distribution of this rare species.   

  16. [Objective functional compensation in NHIL: INAIL prosthesic protocol in Lombardy, 2007-2010].

    Science.gov (United States)

    Calcinoni, O; Polo, L

    2011-01-01

    Even if NHIL gives already right to economic compensation, our Insurance aimed to real functional compensation, to reduce handicap in everyday life. Together with Professor Giordano, Audioprosthesists' Association and Manufacturers' representatives, INAIL Medical Superintendence started in 2003 a study on this problem, involving some of his forensic physician and ENT staff; in 2007-2009 INAIL issued directives innovating and planning the rules in prosthesis provision, not only acoustical ones. In 2010 started an experimental protocol to rule hearing aid provision in all INAIL centers, throughout Italy. Authors present first results of this protocol in Lombardy, related to previous and national ones.

  17. Current status of nanotechnology in urology

    Directory of Open Access Journals (Sweden)

    Suresh K. Goyal

    2016-08-01

    Full Text Available Nanotechnology has been investigated for its applications in medicine. The objective of this review was to summarize the current applications of nanotechnology in Urology. A systematic search of literature was performed and relevant articles were analyzed with specific reference to applications in Urology. Nanotechnology has applications in diagnostic urology like in uroimaging using nanoparticles and nanosensors. It has therapeutic applications in infections, malignancies, genetic disease using targeted drug delivery, gene transfers, nano device-based manipulations etc. Nanotechnology has many applications in Urology. More efforts are required to make these applications practically feasible and affordable. [Int J Res Med Sci 2016; 4(8.000: 3114-3120

  18. [Traditional Chinese medicine in urology].

    Science.gov (United States)

    Hüsch, T; Tsaur, I; Reiter, M; Mager, R; Haferkamp, A

    2014-11-01

    Traditional Chinese medicine (TCM) is an ancient holistic medicine based on the doctrine of Tao and Qi. Tao represents an alteration from which the polarity of Yin and Yang arises and Qi is the vitality which circulates through the body. Therapeutic concepts of TCM include acupuncture, herbal therapy, nutrition and Tuina, a form of manual therapy. TCM is now gaining increased acceptance in the Western society as a complementary therapy. Acupuncture and herbal therapy are the main forms of implementation of TCM in urology.

  19. Changes in urological surgical techniques

    Directory of Open Access Journals (Sweden)

    Oktay Üçer

    2010-06-01

    Full Text Available Recently, laparoscopic and afterwards robotic techniques have constituted most of urologic surgery procedures. Open surgery may give place to robotic surgery due to possible widespread use of robots in the future. Studies, that compare these two techniques are usually designed about radical prostatectomy, since it is the most common operation performed by using these techniques. In literature,robotic surgery seems more advantageous than other techniques but the most important disadvantage of this technique is cost-effective problems. In present review,history of open, laparoscopic and robotic surgery, and comparison of advantages, disadvantages and cost of these techniques have been discussed with literature.

  20. Hollow waveguide for urology treatment

    Science.gov (United States)

    Jelínková, H.; Němec, M.; Koranda, P.; Pokorný, J.; Kőhler, O.; Drlík, P.; Miyagi, M.; Iwai, K.; Matsuura, Y.

    2010-02-01

    The aim of our work was the application of the special sealed hollow waveguide system for the urology treatment - In our experimental study we have compared the effects of Ho:YAG (wavelength 2100 nm) and Er:YAG (wavelength 2940 nm) laser radiation both on human urinary stones (or compressed plaster samples which serve as a model) fragmentation and soft ureter tissue incision in vitro. Cyclic Olefin Polymer - coated silver (COP/Ag) hollow glass waveguides with inner and outer diameters 700 and 850 μm, respectively, were used for the experiment. To prevent any liquid to diminish and stop the transmission, the waveguide termination was utilized.

  1. Motherhood of foreign women in Lombardy: Testing the effects of migration by citizenship

    Directory of Open Access Journals (Sweden)

    Eleonora Mussino

    2015-09-01

    Full Text Available Background: The international literature highlights the strong impact of the high risk of childbearing shortly after migration on period fertility, thus establishing a link between reproductive behaviors and migratory transitions. Objective: The present study aims to analyze how migration affects motherhood and the role played by country of citizenship. Although most of the literature has focused on analyzing post-immigration fertility behaviors, in the present work we follow the women for their entire fertility period. Methods: The data were collected in the 2010 ORIM survey, conducted by the Region of Lombardy and the Ismu Foundation. The survey covered about 8,000 immigrants in Lombardy, of whom 3,848 were women aged 14 years and over from less developed countries or Central/Eastern Europe. Using Event History Analysis, we applied discrete-time logit models to study the transition into motherhood. Results: Moroccans are characterized by a strong interrelation effect between fertility and migration. Moroccans and Albanians are the national groups with the highest risk of having a first child during the years shortly after migration. Migration does not seem to have any effect on the fertility behavior of Romanians, who have a lower risk of having a child regardless of their migration status. Conclusions: The study confirms the importance of the interrelationship between migratory and reproductive behaviors. It also highlights the different effects by country of citizenship, where different citizenships are often associated with different migration patterns and distinct gender roles.

  2. UROLOGIC ROBOTS AND FUTURE DIRECTIONS

    Science.gov (United States)

    Mozer, Pierre; Troccaz, Jocelyne; Stoianovici, Dan

    2009-01-01

    Purpose of review Robot-assisted laparoscopic surgery in urology has gained immense popularity with the Da Vinci system but a lot of research teams are working on new robots. The purpose of this paper is to review current urologic robots and present future developments directions. Recent findings Future systems are expected to advance in two directions: improvements of remote manipulation robots and developments of image-guided robots. Summary The final goal of robots is to allow safer and more homogeneous outcomes with less variability of surgeon performance, as well as new tools to perform tasks based on medical transcutaneous imaging, in a less invasive way, at lower costs. It is expected that improvements for remote system could be augmented reality, haptic feed back, size reduction and development of new tools for NOTES surgery. The paradigm of image-guided robots is close to a clinical availability and the most advanced robots are presented with end-user technical assessments. It is also notable that the potential of robots lies much further ahead than the accomplishments of the daVinci system. The integration of imaging with robotics holds a substantial promise, because this can accomplish tasks otherwise impossible. Image guided robots have the potential to offer a paradigm shift. PMID:19057227

  3. Urologic robots and future directions

    CERN Document Server

    Mozer, Pierre; Stoianovici, Dan; 10.1097/MOU.0b013e32831cc1ba

    2008-01-01

    PURPOSE OF REVIEW: Robot-assisted laparoscopic surgery in urology has gained immense popularity with the daVinci system, but a lot of research teams are working on new robots. The purpose of this study is to review current urologic robots and present future development directions. RECENT FINDINGS: Future systems are expected to advance in two directions: improvements of remote manipulation robots and developments of image-guided robots. SUMMARY: The final goal of robots is to allow safer and more homogeneous outcomes with less variability of surgeon performance, as well as new tools to perform tasks on the basis of medical transcutaneous imaging, in a less invasive way, at lower costs. It is expected that improvements for a remote system could be augmented in reality, with haptic feedback, size reduction, and development of new tools for natural orifice translumenal endoscopic surgery. The paradigm of image-guided robots is close to clinical availability and the most advanced robots are presented with end-use...

  4. URobotics--Urology Robotics at Johns Hopkins.

    Science.gov (United States)

    Stoianovici, D

    2001-01-01

    URobotics (Urology Robotics) is a program of the Urology Department at the Johns Hopkins Medical Institutions dedicated to the development of new technology for urologic surgery (http://urology.jhu.edu/ urobotics). The program is unique in that it is the only academic engineering program exclusively applied to urology. The program combines efforts and expertise from the medical and engineering fields through a close partnership of clinical and technical personnel. Since its creation in 1996, the URobotics lab has created several devices, instruments, and robotic systems, several of which have been successfully used in the operating room. This article reviews the technology developed in our laboratory and its surgical applications, and highlights our future directions.

  5. [Results of an investigation by questionnaire into interest in neuro-urology of urology residents].

    Science.gov (United States)

    Caremel, R; Bernhard, J-C; Bigot, P; Koutlidis, N; Xylinas, E; Faïs, P-O; Rouache, L; Genevois, S; Mazzola, C; Bessede, T; Gosseine, P-N; Celhay, O; Faivre D'Arcier, B; Benchikh, A; Pignot, G; Guillotreau, J

    2010-06-01

    To evaluate the interest borne towards neuro-urology within the community of the urology residents. Between January and May 2009, all urology residents received an anonymous questionnaire by e-mail estimating their interest for neuro-urology. The analyzed data were: epidemiologic data; participation in theoretical learning and training courses practices; interest and investment in the speciality; opinion on the current formation. The qualitative variables were compared by the chi-2 test. P values neuro-urology staff, and 80 % were in a service which dealt with suffering patients of neurological bladder. The percentage of urologist residents interested by neuro-urology was 69,2 %, and 61,5 % of them wished to practice this activity in their future exercise. This wish was significantly higher for those resulting from the ENC (pneuro-urology (pneuro-urology were considered as being insufficient for respectively 73,9 % and 64,2 % of the urologist residents. In contrast, the average note allotted to the neuro-urology module of the ECU was of 7,47 out of 10. Neuro-urology seems to be particularly attractive for the urologist residents, and many wished to integrate it in their future exercise. The motivation was more important for those who wished to carry out a career in hospital. Even if the quality of the teaching was very noted, their modalities were considered to be insufficient by most of them. Copyright 2010. Published by Elsevier Masson SAS.

  6. A methodology for elemental and organic carbon emission inventory and results for Lombardy region, Italy

    Energy Technology Data Exchange (ETDEWEB)

    Caserini, Stefano [Politecnico di Milano, DICA Environmental Engineering Section, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Galante, Silvia, E-mail: silvia1.galante@polimi.it [Politecnico di Milano, DICA Environmental Engineering Section, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Ozgen, Senem; Cucco, Sara; Gregorio, Katia de [Politecnico di Milano, DICA Environmental Engineering Section, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Moretti, Marco [Environmental Protection Agency of Lombardia Region, ARPA, 20124 Milano (Italy)

    2013-04-15

    This paper presents a methodology and its application for the compilation of elemental carbon (EC) and organic carbon (OC) emission inventories. The methodology consists of the estimation of EC and OC emissions from available total suspended particulate matter (TSP) emission inventory data using EC and OC abundances in TSP derived from an extensive literature review, by taking into account the local technological context. In particular, the method is applied to the 2008 emissions of Lombardy region, Italy, considering 148 different activities and 30 types of fuels, typical of Western Europe. The abundances estimated in this study may provide a useful basis to assess the emissions also in other emission contexts with similar prevailing sources and technologies. The dominant sources of EC and OC in Lombardy are diesel vehicles for EC and the residential wood combustion (RWC) for OC which together account for about 83% of the total emissions of both pollutants. The EC and OC emissions from industrial processes and other fuel (e.g., gasoline, kerosene and LPG) combustion are significantly lower, while non-combustion sources give an almost negligible contribution. Total EC + OC contribution to regional greenhouse gas emissions is positive for every sector assuming whichever GWP100 value within the range proposed in literature. An uncertainty assessment is performed through a Monte Carlo simulation for RWC, showing a large uncertainty range (280% of the mean value for EC and 70% for OC), whereas for road transport a qualitative analysis identified a narrower range of uncertainty. - Highlights: ► Diesel and wood combustion contribute to more than 80% of total EC and OC. ► More than 50% of EC emissions come from road transport. ► Monte Carlo method is used to assess the uncertainty of wood combustion emissions. ► Residential wood combustion is the main source of uncertainty of EC OC inventory. ► In terms of CO{sub 2}eq, EC and OC correspond to 3% of CO{sub 2

  7. Cloning and sequencing the degS-degU operon from an alkalophilic Bacillus-brevis

    CSIR Research Space (South Africa)

    Louw, M

    1994-10-01

    Full Text Available at the amino acid level to the B. subtilis degS-degU genes showed 74% and 84% similarity, respectively. On a multicopy vector the B. brevis degS-degU genes were found to cause hypersecretion of several extracellular enzymes in a B. subtilis rec (-) strain...

  8. Advances in Pediatric Urologic Laparoscopy

    Directory of Open Access Journals (Sweden)

    M. C. Smaldone

    2007-01-01

    Full Text Available The spectrum of laparoscopic surgery in children has undergone a dramatic evolution. Initially used as a diagnostic modality for many pediatric urologists, complex as well as reconstructive procedures are now being performed laparoscopically. Laparoscopic orchiopexy and nephrectomy are well established and are being performed at many centers. Laparoscopic partial nephrectomy, adrenalectomy, and dismembered pyeloplasty series have reported shortened hospital stays and operative times that are comparable to that of open techniques or are decreasing with experience. The initial experiences with laparoscopic ureteral reimplantation and laparoscopic-assisted bladder reconstructive surgery have been described, reporting encouraging results with regards to feasibility, hospital stay, and cosmetic outcome. This report will provide a directed review of the literature to establish the current indications for laparoscopy in pediatric urologic surgery.

  9. Urological manifestations of Duchenne muscular dystrophy.

    Science.gov (United States)

    Askeland, Eric J; Arlen, Angela M; Erickson, Bradley A; Mathews, Katherine D; Cooper, Christopher S

    2013-10-01

    Duchenne muscular dystrophy is a dystrophinopathy affecting males that is associated with multiple organ system complications. To our knowledge urological complications of Duchenne muscular dystrophy have been described only anecdotally to date. We reviewed the medical charts of 135 patients with Duchenne or Duchenne-Becker muscular dystrophy for demographics and disease progression, urological diagnoses, intervention and followup. Of 135 patients 67 (50%) had at least 1 documented urological diagnosis and 38 (28%) had multiple manifestations. Lower urinary tract symptoms were the most common urological diagnosis (32% of patients). Survival analysis revealed a median age at onset of lower urinary tract symptoms of 23 years (95% CI 17.7-23.9). Intervention was required in 12 patients (9%), most commonly due to nephrolithiasis. Urological morbidity increased with Duchenne muscular dystrophy progression when stratified by clinical progression. Lower urinary tract symptoms were more common in nonambulatory patients (40.7% vs 19%, p = 0.007), those with a diagnosis of scoliosis (44% vs 19.7%, p = 0.003) and/or scoliosis spine surgery (60% vs 22%, p <0.001), and those on invasive respiratory support (53% vs 29%, p = 0.046). Likewise, nephrolithiasis was more common in nonambulatory patients (10% vs 0%, p = 0.017), those with scoliosis (12% vs 0%, p = 0.004) and/or scoliosis spine surgery (20% vs 1%, p <0.001), and those on invasive respiratory support (29% vs 3%, p <0.001). Only 28% of patients with a urological manifestation were referred to urology. As these patients transition into adolescence and adulthood, the increased prevalence of urological manifestations warrants increased awareness and referral to urologists. Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  10. 21 CFR 876.4530 - Gastroenterology-urology fiberoptic retractor.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Gastroenterology-urology fiberoptic retractor. 876... SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Surgical Devices § 876.4530 Gastroenterology-urology fiberoptic retractor. (a) Identification. A gastroenterology-urology fiberoptic...

  11. 21 CFR 876.4370 - Gastroenterology-urology evacuator.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Gastroenterology-urology evacuator. 876.4370... (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Surgical Devices § 876.4370 Gastroenterology-urology evacuator. (a) Identification. A gastroenterology-urology evacuator is a device used to...

  12. [Asbestos exposure in the non-asbestos textile industry: the experience of the Lombardy Mesothelioma Registry].

    Science.gov (United States)

    Mensi, Carolina; Macchione, Maria; Termine, Lorenzo; Canti, Zulejka; Rivolta, Giuseppe; Riboldi, Luciano; Chiappino, Gerolamo

    2007-01-01

    The Lombardy Mesothelioma Registry, activated in 2000, receives more than 300 cases per year of suspected malignant mesothelioma; the standardized (age and gender) incidence rate of pleural mesothelioma is 2.4/100,000 inhabitants (CI 95% 2.0-2.7). The finding of an increasing number of cases among workers of the non-asbestos-textile industry, classified as "unknown exposure to asbestos", upheld the suspect of presence of asbestos in this compartment. Specific information about a possible asbestos exposure were collected by technicians, maintenance personnel and other experts; industrial machinery utilized in the past was thoroughly examined; direct inspections were carried out in several workplaces that had not yet undergone significant changes with respect to the past. A large amount of asbestos had been regularly used on the ceilings and also to the walls of factories in order to avoid both condensation of steam and reflection of noise. In addition, asbestos had also been widely used to insulate water and steam pipes. The braking systems of most of machines also had asbestos gaskets, and on several looms some brakes operated continuously. The population in study was composed of 119 subjects, 27 males and 92 females, median age of 72 years. Asbestos exposure was ascribed to work in 106 cases (89%). The system devised by the Lombardy Registry had brought to light an occupational hazard in a professional area previously never believed as a source of asbestos exposure. In consideration of the described experience, both environmental and clinical, it seems reasonable to consider the non-asbestos-textile as a new department at risk for asbestos exposure.

  13. A Training Module for Laparoscopic Urology

    OpenAIRE

    2005-01-01

    Objectives: A fellowship training model in laparoscopic urological surgery has been established for interested urologists to help them proceed from the pelvic trainer/ animal laboratory environment to safe clinical practice. The objective of the model is to provide trainees with clinical experience under direct mentor supervision before embarking on independent laparoscopic urological surgery at their own base hospitals. Methods: The fellowship model incorporates 9 fluid phases: Phase 1 to co...

  14. Robotics in urology: past, present, and future.

    Science.gov (United States)

    Thiel, David D; Winfield, Howard N

    2008-04-01

    The modern-day urologist is continually armed with new instruments and technology aimed at decreasing the overall invasiveness of urologic procedures. Robotic technology is aimed at improving clinical outcomes by correcting human technical inadequacies such as hand tremors and imprecise suturing. The first reported use of robotics to assist with surgery was in 1985, and the first use of robotics in urology was published in 1989. The currently utilized master-slave system (da Vinci Robotic Platform), Intuitive Surgical, Sunnyvale, CA) has popularized robotic surgery for use in numerous urologic conditions including prostate cancer, bladder cancer, renal cancer, uretero-pelvic junction obstruction, and pelvic prolapse. New developments in robotic technology may revolutionize many other aspects of urology including percutaneous renal access and rounding on patients after surgery. This review provides a brief overview of the history of robotics in urology, a description of the da Vinci surgical system and its current utilization as well as limitations, and a review of evolving robotic technology in the field of urology.

  15. The impact of robotic surgery in urology.

    Science.gov (United States)

    Giedelman, C A; Abdul-Muhsin, H; Schatloff, O; Palmer, K; Lee, L; Sanchez-Salas, R; Cathelineau, X; Dávila, H; Cavelier, L; Rueda, M; Patel, V

    2013-01-01

    More than a decade ago, robotic surgery was introduced into urology. Since then, the urological community started to look at surgery from a different angle. The present, the future hopes, and the way we looked at our past experience have all changed. Between 2000 and 2011, the published literature was reviewed using the National Library of Medicine database and the following key words: robotic surgery, robot-assisted, and radical prostatectomy. Special emphasis was given to the impact of the robotic surgery in urology. We analyzed the most representative series (finished learning curve) in each one of the robotic approaches regarding perioperative morbidity and oncological outcomes. This article looks into the impact of robotics in urology, starting from its background applications before urology, the way it was introduced into urology, its first steps, current status, and future expectations. By narrating this journey, we tried to highlight important modifications that helped robotic surgery make its way to its position today. We looked as well into the dramatic changes that robotic surgery introduced to the field of surgical training and its consequence on its learning curve. Basic surgical principles still apply in Robotics: experience counts, and prolonged practice provides knowledge and skills. In this way, the potential advantages delivered by technology will be better exploited, and this will be reflected in better outcomes for patients. Copyright © 2012 AEU. Published by Elsevier Espana. All rights reserved.

  16. Summary of European Association of Urology (EAU) Guidelines on Neuro-Urology.

    Science.gov (United States)

    Groen, Jan; Pannek, Jürgen; Castro Diaz, David; Del Popolo, Giulio; Gross, Tobias; Hamid, Rizwan; Karsenty, Gilles; Kessler, Thomas M; Schneider, Marc; 't Hoen, Lisette; Blok, Bertil

    2016-02-01

    Most patients with neuro-urological disorders require life-long medical care. The European Association of Urology (EAU) regularly updates guidelines for the diagnosis and treatment of these patients. To provide a summary of the 2015 updated EAU Guidelines on Neuro-Urology. Structured literature searches in several databases were carried out to update the 2014 guidelines. Levels of evidence and grades of recommendation were assigned where possible. Neurological disorders often cause urinary tract, sexual, and bowel dysfunction. Most neuro-urological patients need life-long care for optimal life expectancy and quality of life. Timely diagnosis and treatment are essential to prevent upper and lower urinary tract deterioration. Clinical assessment should be comprehensive and usually includes a urodynamic investigation. The neuro-urological management must be tailored to the needs of the individual patient and may require a multidisciplinary approach. Sexuality and fertility issues should not be ignored. Numerous conservative and noninvasive possibilities of management are available and should be considered before a surgical approach is chosen. Neuro-urological patients require life-long follow-up and particular attention has to be paid to this aspect of management. The current EAU Guidelines on Neuro-Urology provide an up-to-date overview of the available evidence for adequate diagnosis, treatment, and follow-up of neuro-urological patients. Patients with a neurological disorder often suffer from urinary tract, sexual, and bowel dysfunction and life-long care is usually necessary. The update of the EAU Guidelines on Neuro-Urology, summarized in this paper, enables caregivers to provide optimal support to neuro-urological patients. Conservative, noninvasive, or minimally invasive approaches are often possible. Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  17. Occupational exposure and urological cancer.

    Science.gov (United States)

    Golka, Klaus; Wiese, Andreas; Assennato, Giorgio; Bolt, Hermann M

    2004-02-01

    Occupational exposure is definitely a major cause of cancer. In the field of urology, the urinary bladder is the most important target. A classical cause of bladder cancer is exposure to carcinogenic aromatic amines, especially benzidine and beta-naphthylamine. Such exposures were related to work places in the chemical industry, implying production and processing of classical aromatic amines, and in the rubber industry. Occupational bladder cancer has also been observed in dyers, painters and hairdressers. Even some occupations with much lower exposures to carcinogenic aromatic amines, like coke oven workers or workers in the rubber industry after the ban on beta-naphthylamine, are at risk. In these occupations, exposure to complex mixtures of substances containing combustion products (e.g. polycyclic aromatic hydrocarbons) or nitrosamines is common. Renal cell cancer has been observed as an occupational disease in cases of very high exposure to trichloroethylene having led to narcotic or prenarcotic symptoms. Occupationally related cancers of the prostate or the testes appear currently not relevant.

  18. Fisica degli atomi e dei nuclei

    CERN Document Server

    Bernardini, Carlo

    1965-01-01

    Evidenza della struttura atomica della materia ; le proprietà degli atomi e la meccanica atomica ; gli atomi e le radiazioni elettromagnetiche ; struttura microscopica dello stato gassoso ; struttura microscopica dello stato liquido ; struttura microscopica della stato solido ; proprietà elettriche e magnetiche delle sostanze ; proprietà dei nuclei degli atomi ; le particelle elementari.

  19. Conservation agriculture practices to enhance soil organic in Lombardy plain (Northern Italy)

    Science.gov (United States)

    Perego, Alessia; Giussani, Andrea; Corsi, Stefano; Tosini, Andrea; Acutis, Marco

    2016-04-01

    It has been demonstrated that conservation agriculture (CA) determines a long-term increase in soil organic carbon (SOC) stock in cropland. The present study aimed to estimate the amount of SOC stored in soil of Lombardy plain (Northern Italy) following the change from tillage agriculture (TA) to CA by using crop ARMOSA crop over 23 years (1989-2011). The territorial analysis was performed at agrarian region scale (AR) after identification of the representative crops rotation and soil types. The land use information were data available at cadastral scale and referred to 5 years (from 2007 to 2011). The meteorological data (i.e. maximum and minimum temperature, precipitation) were measured at 14 monitoring stations. Solar radiation was estimated using the equation of the Bristow and Campbell model (1994). A spatial interpolation method was used to extend the meteorological data throughout the entire plain of the region by employing Thiessen polygon method; the meteorological data of the polygon were assigned to each AR. ARMOSA was parameterized to simulate the two tillage systems. For TA and CA scenario the depth of tillage was limited to 35 and 10 cm, respectively; crop residual incorporation was not simulated under CA. In TA scenario, we used the parameters calibrated and validated by Perego et al.(2013) on a wide dataset collected at six monitoring sites in Lombardy plain. In CA, the rate of C decomposition of humified organic C was assumed to be smaller by 30% in no-tillage than in TA (Oorts et al., 2007). The model results showed a significant improve of SOC (pmaize monoculture with or without cover crop. References: Oorts K., Garnier P., Findeling A., Mary B., Richard G., Nicolardot B., (2007). Modeling soil carbon and nitrogen dynamics in no-till and conventional tillage using PASTIS model. Soil Sci. Soc. Am. J., 7, pp. 336-346 Perego A., Giussani A., Sanna M., Fumagalli M., Carozzi M., Alfieri L., Brenna S., Acutis M., 2013. The ARMOSA simulation crop model

  20. Contrast induced nephropathy in urology

    Directory of Open Access Journals (Sweden)

    Viji Samuel Thomson

    2009-01-01

    Full Text Available Intravenous contrast agents have a distinct role in urological imaging: to study precise anatomical delineation, vascularity, and to assess the function of the renal unit. Contrast induced nephropathy (CIN is a known adverse effect of intravenous contrast administration. The literature on incidence, pathophysiology, clinical features, and current preventive strategies available for CIN relevant to urologists was reviewed. A search of the PubMed database was done using the keywords nephropathy and media, prevention and control or prevention Contrast media (explode, all adverse effects, and kidney diseases (explode. An online search of the EMBASE database for the time ranging from 1977 to February 2009 was performed using the keywords ionic contrast medium, adverse drug reaction, major or controlled clinical study, human, nephrotoxicity, and kidney disease. Current publications and data most relevant to urologists were examined. CIN was the third most common cause of hospital-acquired renal failure. The incidence is less common with intravenous contrast administration as compared with intra-arterial administration. The pathogenesis of contrast mediated nephropathy is due to a combination of toxic injury to renal tubules and medullary ischemic injury mediated by reactive oxygen species. CIN most commonly manifests as a nonoliguric and asymptomatic transient decline in renal function. Patients who developed CIN were found to have increased mortality, longer hospital stay, and complicated clinical course. An overview of risk factors and risk prediction score for prognostication of CIN are elaborated. Preventive strategies including choice of contrast agents, maximum tolerated dose, role of hydration, hydration regime, etc. are discussed. The role of N- acetyl cysteine, Theophylline, Fenoldapam, Endothelin receptor antagonists, iloprost, atrial natriuretic peptide, and newer therapies such as targeted renal therapy (TRT are discussed. A working

  1. New paleoradiological investigations of ancient human remains from North West Lombardy archaeological excavations.

    Science.gov (United States)

    Licata, Marta; Borgo, Melania; Armocida, Giuseppe; Nicosia, Luca; Ferioli, Elena

    2016-03-01

    Since its birth in 1895, radiology has been used to study ancient mummies. The purpose of this article is to present paleoradiological investigations conducted on several medieval human remains in Varese province. Anthropological (generic identification) and paleopathological analyses were carried out with the support of diagnostic imaging (X-ray and CT scans). Human remains were discovered during excavations of medieval archaeological sites in northwest Lombardy. Classical physical anthropological methods were used for the macroscopic identification of the human remains. X-ray and CT scans were performed on the same scanner (16-layer Hitachi Eclos 16 X-ray equipment). Results Radiological analysis permitted investigating (1) the sex, (2) age of death, (3) type of trauma, (4) therapeutic interventions and (5) osteomas in ancient human remains. In particular, X-ray and CT examinations showed dimorphic facial traits on the mummified skull, and the same radiological approaches allowed determining the age at death from a mummified lower limb. CT analyses allow investigating different types of traumatic lesions in skulls and postcranial skeleton portions and reconstructing the gait and functional outcomes of a fractured femur. Moreover, one case of possible Gardner’s syndrome (GS) was postulated from observing multiple osteomas in an ancient skull. Among the medical tests available to the clinician, radiology is the most appropriate first-line procedure for a diagnostic approach to ancient human remains because it can be performed without causing any significant damage to the specimen.

  2. Leibniz's Observations on Hydrology: An Unpublished Letter on the Great Lombardy Flood of 1705.

    Science.gov (United States)

    Strickland, Lloyd; Church, Michael

    2015-01-01

    Although the historical reputation of Gottfried Wilhelm Leibniz (1646-1716) largely rests on his philosophical and mathematical work, it is widely known that he made important contributions to many of the emerging but still inchoate branches of natural science of his day. Among the many scientific papers Leibniz published during his lifetime are ones on the nascent science we now know as hydrology. While Leibniz's other scientific work has become of increasing interest to scholars in recent years, his thinking about hydrology has been neglected, despite being relatively broad in extent, including as it does papers on the 'raising of vapours' and the formation of ice, as well as the separation of salt and fresh water. That list can now be extended still further following the discovery of a previously unpublished letter of Leibniz's on the causes of the devastating Lombardy flood of October and November 1705. This letter, which will be the focus of our paper, reveals the depth of Leibniz's understanding of key hydrological processes. In it, he considers various mechanisms for the flood, such as heavy rains on high ground, underwater earthquakes, and a mountain collapse. Over the course of the paper we examine each of these mechanisms in depth, and show that Leibniz was in the vanguard of hydrological thinking. We also show that the letter contains one of the first scholarly attempts to apply aspects of the still-forming notion of the hydrological cycle to account for a flood event.

  3. New paleoradiological investigations of ancient human remains from North West Lombardy archaeological excavations

    Energy Technology Data Exchange (ETDEWEB)

    Licata, Marta; Borgo, Melania; Armocida, Giuseppe; Nicosia, Luca; Ferioli, Elena [University of Insubria (Varese), Department of Biotechnology and Life Sciences, Varese (Italy)

    2016-03-15

    Since its birth in 1895, radiology has been used to study ancient mummies. The purpose of this article is to present paleoradiological investigations conducted on several medieval human remains in Varese province. Anthropological (generic identification) and paleopathological analyses were carried out with the support of diagnostic imaging (X-ray and CT scans). Human remains were discovered during excavations of medieval archaeological sites in northwest Lombardy. Classical physical anthropological methods were used for the macroscopic identification of the human remains. X-ray and CT scans were performed on the same scanner (16-layer Hitachi Eclos 16 X-ray equipment). Radiological analysis permitted investigating (1) the sex, (2) age of death, (3) type of trauma, (4) therapeutic interventions and (5) osteomas in ancient human remains. In particular, X-ray and CT examinations showed dimorphic facial traits on the mummified skull, and the same radiological approaches allowed determining the age at death from a mummified lower limb. CT analyses allow investigating different types of traumatic lesions in skulls and postcranial skeleton portions and reconstructing the gait and functional outcomes of a fractured femur. Moreover, one case of possible Gardner's syndrome (GS) was postulated from observing multiple osteomas in an ancient skull. Among the medical tests available to the clinician, radiology is the most appropriate first-line procedure for a diagnostic approach to ancient human remains because it can be performed without causing any significant damage to the specimen. (orig.)

  4. Community residential facilities in mental health services: A ten-year comparison in Lombardy.

    Science.gov (United States)

    Barbato, Angelo; Civenti, Graziella; D'Avanzo, Barbara

    2017-06-01

    Residential mental health services grew steadily since 2000 in Italy. A reorganisation of residential facilities was implemented in 2007 in Lombardy, introducing supported housing in addition to staffed facilities. We compare the provision and characteristics of residential facilities in the 2007 and 2016. In 2007 there were 3462 beds (35.9/100,000 population) in 276 facilities. In 2016 beds were 4783 (47.8/100,000) in 520 facilities. The increase were unevenly distributed in the public and private sector, and the overall increase was due to a higher increase in the private sector. 72% of beds were in highly supervised facilities in 2007 and 66% in 2016. The public sector managed more facilities with a rehabilitation goal, while the private sector more for long-term accommodation. Mean numbers of beds were higher in facilities managed by the private sector in both years. The 2007 reorganisation and the stop to opening new facilities in the last years were not enough to correct the imbalance between highly supervised and flexible solutions. A wider and more diverse offer might have triggered off an increased demand, rather than a more rational use. Given the costs of highly staffed facilities, and the risk of reproducing custodial models, close evaluation of the use of residential facilities should inform policies. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. The economy of charity and forgiveness. Alms and indulgences in late medieval Lombardy

    Directory of Open Access Journals (Sweden)

    Giuliana Albini

    2016-05-01

    Full Text Available In the late Middle Ages, one of the ways to support hospitals and confraternities was the collection of alms, associated with the granting of indulgences. Through confession, the believers acquired the forgiveness from sins, and through acts of devotion and charity the reduction of the punishment to expiate in the afterlife (in Purgatory. Although studies on the topic are scarce, it is not risked to say that the indulgences had a particular luck in charities. The following pages are designed to provide new elements about the ways in which, in Lombardy, hospitals and confraternities guaranteed themselves privileges for indulgences given by the Pope and by the bishops. A special effort has been made to quantify (whenever the sources allowed to do it the costs that the institution had to incur for the management of a campaign of indulgences and the economic benefits derived from it. If in certain hospital orders the economic impact of collecting money seems to be relevant, in other cases it appears marginal. This latter is the case of the Great Hospital in Milan, which does not seem to depend on the collection of money linked to indulgences. But, despite this reduced economic impact, the Hospital reserved an important role on the "festa del Perdono" (indulgence granted by Pope Pius II, because, in the context of charity and assistance, the symbolic and communicative value was important like the material aid to the poors.

  6. Robot-assisted surgery: applications in urology

    Directory of Open Access Journals (Sweden)

    Mathew C Raynor

    2010-05-01

    Full Text Available Mathew C Raynor, Raj S PruthiDivision of Urologic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAAbstract: The past decade has seen a dramatic shift in the surgical management of certain urologic conditions with the advent of a robotic surgical platform. In fact, the surgical management of prostate cancer has seen the most dramatic shift, with the majority of cases now being performed robotically. Technical refinements over the years have led to improved outcomes regarding oncologic and functional results. Recently, robotic surgery has also been utilized for the surgical management of bladder cancer, renal cancer, and other benign conditions. As further experience is gained and longer-term outcomes are realized, robotic surgery will likely play an increasing role in the surgical management of many urologic conditions.Keywords: robot-assisted surgery, robotic surgery, cystectomy, prostatectomy, partial nephrectomy

  7. Extracorporeal shock wave therapy (ESWT) in urology

    DEFF Research Database (Denmark)

    Fojecki, Grzegorz Lukasz; Thiessen, Stefan; Osther, Palle Jörn Sloth

    2017-01-01

    PURPOSE: The objective was to evaluate high-level evidence studies of extracorporeal shock wave therapy (ESWT) for urological disorders. METHODS: We included randomized controlled trials reporting outcomes of ESWT in urology. Literature search on trials published in English using EMBASE, Medline...... and PubMed was carried out. The systematic review was performed according to PRISMA guidelines. RESULTS: We identified 10 trials on 3 urological indications. Two of 3 trials on Peyronie's disease (PD) involving 238 patients reported improvement in pain; however, no clinical significant changes in penile......i) responders in 2 of 4 trials and 3 of 4 trials, respectively. Three studies on chronic pelvic pain (CPP) engaging 200 men reported positive changes in National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). There was considerable heterogeneity between trials both with regard...

  8. Resorbable extracellular matrix grafts in urologic reconstruction

    Directory of Open Access Journals (Sweden)

    Richard A. Santucci

    2005-06-01

    Full Text Available PURPOSE: There is an increasingly large body of literature concerning tissue-engineering products that may be used in urology. Some of these are quite complex (such as multilayer patient-specific cell-seeded implants yet the most simple and successful products to date are also the most uncomplicated: resorbable acellular extra-cellular matrices (ECMs harvested from animals. ECMs have been used in a variety of difficult urologic reconstruction problems, and this review is intended to summarize this complex literature for the practicing urologist. METHODS: Medline search of related terms such as "SIS, small intestinal submucosa, ECM, extracellular matrix, acellular matrix and urologic reconstruction". Manuscripts missed in the initial search were taken from the bibliographies of the primary references. RESULTS: Full review of potential clinical uses of resorbable extra-cellular matrices in urologic reconstruction. CONCLUSIONS: Currently, the "state of the art" in tissue engineering solutions for urologic reconstruction means resorbable acellular xenograft matrices. They show promise when used as a pubovaginal sling or extra bolstering layers in ureteral or urethral repairs, although recent problems with inflammation following 8-ply pubovaginal sling use and failures after 1- and 4-ply SIS repair of Peyronie's disease underscore the need for research before wide adoption. Preliminary data is mixed concerning the potential for ECM urethral patch graft, and more data is needed before extended uses such as bladder augmentation and ureteral replacement are contemplated. The distant future of ECMs in urology likely will include cell-seeded grafts with the eventual hope of producing "off the shelf" replacement materials. Until that day arrives, ECMs only fulfill some of the requirements for the reconstructive urologist.

  9. 21 CFR 876.1075 - Gastroenterology-urology biopsy instrument.

    Science.gov (United States)

    2010-04-01

    ... generic type of device includes the biopsy punch, gastrointestinal mechanical biopsy instrument, suction... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Gastroenterology-urology biopsy instrument. 876... Gastroenterology-urology biopsy instrument. (a) Identification. A gastroenterology-urology biopsy instrument is...

  10. 21 CFR 876.4890 - Urological table and accessories.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Urological table and accessories. 876.4890 Section 876.4890 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Surgical Devices § 876.4890 Urological table...

  11. 21 CFR 876.5160 - Urological clamp for males.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Urological clamp for males. 876.5160 Section 876.5160 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Therapeutic Devices § 876.5160 Urological clamp for...

  12. Publication misrepresentation among urology residency applicants.

    Science.gov (United States)

    Hsi, Ryan S; Hotaling, James M; Moore, Tarah N; Joyner, Byron D

    2013-06-01

    To assess the extent and types of publication misrepresentation among medical students applying to the urology residency program at the University of Washington. Research experience and publications are the selection criteria used to judge and rank urology residency applicants. Electronic Residency Application Service (ERAS) applications submitted for the incoming class of 2011 for urology residency at the University of Washington were reviewed. All listed publications were verified against PubMed and Google search engines. Misrepresentation was defined as non-authorship of an existing article, authorship claimed of a nonexistent article, or first-authorship listed incorrectly. Of the 198 total applications, 124 (63 %) applicants reported 541 publications, including 112 abstracts and 429 journal articles. 347 (65 %) articles and abstracts were verifiable. Misrepresentation of 12 (3.5 %) published articles was found in 9 applicants (7 %), which included self-promotion to first-authorship (6), followed by non-existent articles (5), and a repeated publication listing (1). On univariate analysis, higher age (p = 0.008), higher number of total publications reported (p misrepresentation. Due to the low incidence, the study was not adequately powered to perform a multivariate analysis. Misrepresentation of publications listed in ERAS among urology applicants remains significant. Residency program directors should require applicants to submit copies of all of their publications, whether in print, in-press, or submitted to be placed as part of their application file.

  13. 3D Printing and Its Urologic Applications

    Science.gov (United States)

    Soliman, Youssef; Feibus, Allison H; Baum, Neil

    2015-01-01

    3D printing is the development of 3D objects via an additive process in which successive layers of material are applied under computer control. This article discusses 3D printing, with an emphasis on its historical context and its potential use in the field of urology. PMID:26028997

  14. UROLOGY IN AFRICA AND THE INTERNET

    African Journals Online (AJOL)

    Department of Urology, Nelson R. Mandela School of Medicine, University of Natal, Durban,. South Africa .... any colleague in the world with the price of a local phone call. .... unrealistic dream but is a reality which can be achieved via ...

  15. Raman spectroscopy and its urological applications

    Directory of Open Access Journals (Sweden)

    Vishwanath S Hanchanale

    2008-01-01

    Conclusion: Raman spectroscopy is an exciting tool for real-time diagnosis and in vivo evaluation of living tissue. The potential applications of Raman spectroscopy may herald a new future in the management of various malignant, premalignant, and other benign conditions in urology.

  16. 3D Printing and Its Urologic Applications.

    Science.gov (United States)

    Soliman, Youssef; Feibus, Allison H; Baum, Neil

    2015-01-01

    3D printing is the development of 3D objects via an additive process in which successive layers of material are applied under computer control. This article discusses 3D printing, with an emphasis on its historical context and its potential use in the field of urology.

  17. A new rock glacier inventory of the Lombardy, Central Alps, Italy

    Science.gov (United States)

    Scotti, R.; Brardinoni, F.; Alberti, S.; Frattini, P.; Crosta, G. B.

    2012-04-01

    The Lombardy Alps, with a surface of 2148 km2 above 2000 m a.s.l. (9% of the total) represents an important portion of the southern side of the orogen. For encompassing a variety of tectonic and climatic regimes, they represent an interesting area to examine environmental controls on periglacial processes. Today, technological developments in remote sensing techniques allow us to study periglacial landforms with increasing detail. We present a new inventory for the whole Lombardy Alps in which we identify and classify rock glaciers and protalus ramparts. The inventory has been conducted by combining a number of remotely-sensed images with field traverses. Specifically, the interpretation of high-resolution (0.5 x 0.5 m) digital aerial photos (2000, 2003, 2007) and a 2 m*2 m Digital Surface Model that cover the whole region has allowed inventorying a greater number of relevant landforms when compared to prior regional efforts. Measurements and photographs taken during fieldwork provided critical ground control for the validation of data extracted from remotely-based analysis. Rock glaciers have been mapped in GIS polygons. The inventory follows the specifics detailed by Scapozza and Mari (2010), with some additional information adapted from the PermaNET evidences guidelines (Cremonese et al., 2011). Landform attributes include, geographic coordinates, mountain sector, type, activity, area, elevation (min, max and mean), slope gradient, slope aspect, dominant lithology, vegetation at the front, and upstream presence/absence of a glacier. In total, we identify 1734 periglacial landforms covering a surface of 81,5 km2 (0,34% of the region). In terms of activity, the inventory includes 673 (39%) intact classified and 1061 (61%) relict landforms. The most common landform typology is the talus-lobate (931, 54%) followed by talus tongue-shaped (436, 25%) and protalus ramparts (232, 13%). Minimum elevation, often considered a good approximation of discontinuous permafrost

  18. CAND-LO 2014-15 study: changing epidemiology of candidemia in Lombardy (Italy).

    Science.gov (United States)

    Prigitano, Anna; Cavanna, Caterina; Passera, Marco; Ossi, Cristina; Sala, Eugenio; Lombardi, Gianluigi; Grancini, Anna; De Luca, Concetta; Bramati, Simone; Gelmi, Marina; Tejada, Milvana; Grande, Romualdo; Farina, Claudio; Lallitto, Fabiola; Tortorano, Anna Maria

    2016-12-01

    The aim of this study was to monitor recent changes in the epidemiology of candidemia and in the antifungal susceptibility profiles of Candida isolates in one Italian region (Lombardy) in 2014-2015 in comparison with two other studies performed in the same area in 1997-1999 and in 2009. A laboratory-based surveillance was conducted in 11 microbiology laboratories. Identification of Candida isolates from 868 episodes and antifungal susceptibility testing (YeastOne) was performed locally. A progressive increase in the rate of candidemia up to 1.27/1000 admissions and 1.59/10,000 patient days was documented. In all the three surveys, Candida albicans remains the most frequently isolated species, ranging from 52 to 59 % of the etiology of BSIs. The epidemiological shift to the more resistant C. glabrata, observed between 1997-1999 and 2009 surveys, was not confirmed by our more recent data. The pattern of etiology of BSIs occurred in 2014-2015 overlaps that of the 90s. Acquired antifungal resistance is a rare event. No isolate had an amphoterin B minimal inhibitory concentration (MIC, mg/L) value higher than the epidemiological cutoff. All the echinocandin MIC distributions are typical for wild-type organisms except for those of two C. glabrata isolates. Fluconazole resistance declined from 24.9 % in the 2009 survey to 5.4 % in the recent one. Data from regional surveys may highlight the influence of therapeutic practices on the epidemiology of Candida BSIs and may optimize empirical therapies.

  19. The organized contadi. Administration and territoriality of "rural communities" in four districts of Lombardy (1210-1250 ca

    Directory of Open Access Journals (Sweden)

    Paolo Gabriele Nobili

    2013-01-01

    Full Text Available The paper deals with the evolution in the administrations of four Contadi in central and eastern cities of Lombardy (Bergamo, Brescia, Lodi and Mantova. It begins by examining the estate surveys that in the whole area start from the first two decades of the thirteenth century. These surveys will become instruments of knowledge of local territories. In addition it considers the legislation with which the city was seeking to build an active territoriality of the communities in the district. The district is also divided by cities into smaller administrative entities: the rural communities.

  20. Urology in Stettin (Szczecin). The impact of political changes on progress in urology and medicine.

    Science.gov (United States)

    Zajaczkowski, Tadeusz; Wojewska-Zajaczkowska, Elzbieta

    2012-01-01

    The history of modern hospitals in Stettin is about 280 years long. The history of urology in Stettin (Szczecin), like in Europe, is closely associated with the construction of the useful cystoscope, discovery of X-rays, and progress in radiology and endoscopy. In Stettin, like in many other cities, patients with urological diseases were treated at departments of surgery or departments of internal medicine. On March 1It, 1919, a specialized urology ward with 27 beds was opened in the Municipal Hospital in Stettin. Dr. Felix Hagen from Berlin was the first head of this ward. The main duty of the urology ward at that time was to conduct differential diagnosis and to offer conservative treatment to patients not needing surgery. Cystoscopy, chromocystoscopy, and radiographs were done in the beginning. Later on, retroperitoneal pneumography, pneumopyelography, and retrograde pyelography were added. Urography in the final period enabled a more precise assessment of the kidney prior to surgery. The preparation of patients with benign prostate hyperplasia for surgery was an important element. Therapeutic activities of the urology ward included transurethral procedures such as lithotripsy of bladder stones and treatment of bladder cancer. Urological surgery was done at the surgery ward. Patients with tuberculosis were usually referred to the Tuberculosis Hospital in Hohenkrug (Zdunowo). In 1935, the urology ward in Stettin was closed and incorporated into the surgery ward. During the World War II, just as during the World War I, the Municipal Hospital in Stettin was transformed into a field hospital. The end of the World War II created a new political situation in Europe. Stettin (Szczecin) and West Pomerania became part of Poland. In 1948, the Polish government established the Pomeranian Medical Academy (PAM) in Stettin. During the first 10 years of its existence all urological operations were performed at surgery wards. In August 1955, a 30-bed urology ward affiliated

  1. [The history of urologic journalism in Spain (II). Chronology of Spanish publications specialized in urologic topics].

    Science.gov (United States)

    Maganto Pavón, E

    1996-11-01

    The history of Spanish urological periodicals, like that of the surgical specialties, encompasses several periods as the specialties emerge, are then defined and finally established. It is difficult to determine precisely when the urological specialty began in Spain, since there were surgeons with some dedication to Urology early in the 19th century. Perhaps it began in 1884, when the first service dedicated to the diseases of the urinary tract was created at the Instituto de Terapéutica Operatoria (Institute of Surgical Therapeutics) of the Hospital de la Princesa in Madrid. Although some periodicals with urological descriptions that date back to an earlier period (1800-1850) can be found, it is widely recognized that regular publication of literature and periodicals on the urinary tract started in the mid-19th century, when 'El Especialista' (The Specialist) first appeared in Madrid in 1859. This was the first non monographic specialized periodical where the section 'Genitourinary Disorders' appeared for the first time together with three other specialties. During this second period, journal names were nonspecific or too comprehensive to the point that other medical fields became indiscernible, but they became more explicit as the specialties became more defined. In 1887, the first issue of 'Gaceta de Enfermedades de los Organos Génito-Urinarios' (Gazette of Diseases of the Genitourinary Organs) was published in Madrid. It was the first Spanish journal dedicated exclusively to urological topics. It ushered in a third period, which can be defined as the period of specialized monographic publications, that concluded in 1911 with the founding of the Asociación Española de Urología (Spanish Urological Society). The present article reviews the historical and bibliographical data concerning the six periodicals that were established during these two latter periods.

  2. Current status of robotics in urologic laparoscopy.

    Science.gov (United States)

    Gettman, Matthew T; Blute, Michael L; Peschel, Reinhard; Bartsch, Georg

    2003-02-01

    Urology has continuously embraced novel technologies like laparoscopy that reduce patient morbidity yet maintain an excellent standard of care. Because of limitations on maneuverability, operative vision, manual dexterity, and tactile sense, laparoscopy can be more difficult to perform than corresponding tasks in open surgery. To potentially increase clinical applicability of laparoscopy, robots that enhance operative performance have recently been introduced for a variety of laparoscopic procedures such as laparoscopic radical prostatectomy, pyeloplasty, and even laparoscopic cystectomy and neobladder construction. While these robots have generated excitement and many robotic applications have been described, the benefit of the advanced technology in expanded series of patients remains largely unknown. In addition, the ability of telerobotics to be used by surgeons inexperienced in conventional laparoscopy is also poorly understood. This review compares current features of available robots, advantages and limitations of robots, the emerging clinical applications, and the future potential of robotics in urology.

  3. Hatha Yoga therapy management of urologic disorders.

    Science.gov (United States)

    Ripoll, Emmey; Mahowald, Dawn

    2002-11-01

    Hatha Yoga (often referred to as "yoga") is an ancient type of physical and mental exercise that has been used as a therapeutic modality in traditional Indian medicine for centuries. Yoga as a complementary modality in western medicine is more recent and continues to grow. Chronic urologic disorders are often difficult to diagnose because their presentation mimic other medical conditions and are often a diagnosis of exclusion. Treatment is also frustrating because the more traditional treatments are often unsuccessful in managing chronic disorders. Health care practitioners are often forced to look elsewhere for other modalities to provide pain relief and improve quality of life. Hatha Yoga is one of these modalities which has been extremely useful to many patients in reducing the suffering seen with chronic urologic conditions such as: prostatodynia, chronic orchitis, chronic epididymitis, vulvodynia, interstitial cystitis, etc.

  4. Post-transplant urological and vascular complications

    Directory of Open Access Journals (Sweden)

    Safa Javid

    2009-01-01

    Full Text Available To determine the prevalence of urological and vascular complications in renal trans-plant recipients (RTx at Tabriz Renal Transplant Center, we studied 55 recipients of renal allo-grafts (25 male and 29 female patients with a mean age of 38.3 ± 13.4 years from October 2005 to November 2006. The surgical complications in our study included hematomas: 20.4%, renal artery stenosis: 20.4%, calculi: 7.4%, hydronephrosis or ureteral stricture: 5.6%, urinary leakage: 5.6%, lymphoceles: 1.9%, and renal vein thrombosis: 1.9%. We conclude that the most common urologic complications in our center were ureteric strictures and urine leaks, and the most common vascular complication was renal artery stenosis.

  5. Compensated-power differential calorimeter -196 deg. C/400 deg. C; Calorimetre differentiel a puissance compensee -196 deg. C/400 deg. C

    Energy Technology Data Exchange (ETDEWEB)

    Bonjour, E.; Pierre, J.; Agagliate, S.; Bertrand, P.; Faivre, J.; Lagnier, R. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires, Section physico-chimie et basses temperatures

    1967-06-01

    A differential calorimetric device of original design is described. Its allows direct measurements of thermal effects (adsorption or release) during a linear rise of temperature. The self compensated power method which is applied by means of a very sensitive control system, gives a direct value of the different heat capacity between the sample and a dummy of it. The detection threshold is about {+-} 100 micro-watts to {+-} 250 micro-watts. Applications: - Generally measurements of enthalpy changes of massive or powdered samples. - Measurement of Wigner energy after low temperature irradiation (77 deg. K). - Measurements of energy release in low temperature (77 deg. K) cold worked metals. (authors) [French] On decrit un dispositif de calorimetrie differentielle, de conception originale, qui permet de mesurer directement des effets thermiques en absorption ou en degagement de chaleur, au cours d'une montee en temperature lineaire. La methode de compensation automatique de puissance qui est mise en oeuvre au moyen de cha es d'asservissement tres sensibles, conduit a une determination directe de la capacite calorifique differencielle entre l'echantillon et sa reference. Le seuil de detection est de l'ordre de {+-} 100 a {+-} 250 microwatts. Applications: - D'une facon generale, mesure des variations enthalpiques, sur echantillons massifs ou en poudre. - Mesure de l'energie Wigner apres irradiation a basse temperature (77 deg. K). - Mesure de l'energie restauree apres deformation des metaux a basse temperature (77 deg. K). (auteurs)

  6. Testimonianze di vittime degli anni di piombo

    DEFF Research Database (Denmark)

    Cecchini, Leonardo

    Testimonianze di vittime degli anni di piombo In un articolo pubblicato nel 2008 sulla webzine Nazione indiana Christian Raimo criticava quello che poi Giovanni De Luna qualche anno dopo nel suo libro La Repubblica del dolore (2011) ha chiamato “paradigma vittimario”; cioè la presenza predominante...

  7. Descriptive epidemiology of selected birth defects, areas of Lombardy, Italy, 1999

    Directory of Open Access Journals (Sweden)

    Frassoldi Emanuela

    2007-05-01

    Full Text Available Abstract Background Birth defects are a leading cause of neonatal and infant mortality in Italy, however little is known of the etiology of most defects. Improvements in diagnosis have revealed increasing numbers of clinically insignificant defects, while improvements in treatment have increased the survival of those with more serious and complex defects. For etiological studies, prevention, and management, it is important to have population-based monitoring which provides reliable data on the prevalence at birth of such defects. Methods We recently initiated population-based birth defect monitoring in the Provinces of Mantova, Sondrio and Varese of the Region of Lombardy, northern Italy, and report data for the first year of operation (1999. The registry uses all-electronic source files (hospital discharge files, death certificates, regional health files, and pathology reports and a proven case-generation methodology, which is described. The data were checked manually by consulting clinical records in hospitals. Completeness was checked against birth certificates by capture-recapture. Data on cases were coded according to the four-digit malformation codes of the International Classification of Diseases, Ninth Revision (ICD-9. We present data only on selected defects. Results We found 246 selected birth defects in 12,008 live births in 1999, 148 among boys and 98 among girls. Congenital heart defects (particularly septal defects were the most common (90.8/10,000, followed by defects of the genitourinary tract (34.1/10, 000 (particularly hypospadias in boys, digestive system (23.3/10,000 and central nervous system (14.9/10,000, orofacial clefts (10.8/10,000 and Down syndrome (8.3/10,000. Completeness was satisfactory: analysis of birth certificates resulted in the addition of two birth defect cases to the registry. Conclusion This is the first population-based analysis on selected major birth defects in the Region. The high birth prevalences for

  8. Forest condition and chemical characteristics of atmospheric depositions: research and monitoring network in Lombardy

    Directory of Open Access Journals (Sweden)

    Flaminio DI GIROLAMO

    2002-09-01

    Full Text Available Since 1987, the Regional Forestry Board of Lombardy and the Water Research Institute of the National Research Council have been carrying out surveys of forest conditions and the response of the ecosystem to environmental factors. The study approach is based on a large number of permanent plots for extensive monitoring (Level 1. At this level, crown condition is assessed annually, and soil condition and the nutritional status of forests surveyed. Some of the permanent plots were selected for intensive monitoring (Level 2, focussing mainly on the impact of atmospheric pollution on forest ecosystems. Level 2 monitoring also includes increment analyses, ground vegetation assessment, atmospheric deposition, soil solution analyses and climatic observations. This paper summarises the main results of a pluriannual research, which provides a general picture of the state of forest health in the region and focuses on more detailed investigations, described as case studies. Modified wet and dry samplers which use a water surface to collect dry deposition were used in a pluriannual field campaign at five sites in alpine and prealpine areas, to measure the total atmospheric depositions and to evaluate the nitrogen and sulphate exceedances of critical loads. Throughfall and bulk precipitation chemistry were studied for five years (June 1994-May 1999 at two high elevation forest sites (Val Gerola and Val Masino which were known to differ in terms of tree health, as assessed by live crown condition. Results indicated a higher contribution from the dry deposition of N-NO3 -, N-NH4 + and H+ and considerable canopy leaching of Ca2+, K+ and weak organic acids at Val Gerola, where the symptoms of damage were more evident. In the area of Val Masino (SO, included since 1997 in the national CONECOFOR network, investigations focused on the effectiveness of the biological compartment in modifying fluxes of atmospheric elements, and on the role of nitrogen both as an

  9. Minimal Invasive Urologic Surgery and Postoperative Ileus

    Directory of Open Access Journals (Sweden)

    Fouad Aoun

    2015-07-01

    Full Text Available Postoperative ileus (POI is the most common cause of prolonged length of hospital stays (LOS and associated healthcare costs. The advent of minimal invasive technique was a major breakthrough in the urologic landscape with great potential to progress in the future. In the field of gastrointestinal surgery, several studies had reported lower incidence rates for POI following minimal invasive surgery compared to conventional open procedures. In contrast, little is known about the effect of minimal invasive approach on the recovery of bowel motility after urologic surgery. We performed an overview of the potential benefit of minimal invasive approach on POI for urologic procedures. The mechanisms and risk factors responsible for the onset of POI are discussed with emphasis on the advantages of minimal invasive approach. In the urologic field, POI is the main complication following radical cystectomy but it is rarely of clinical significance for other minimal invasive interventions. Laparoscopy or robotic assisted laparoscopic techniques when studied individually may reduce to their own the duration and prevent the onset of POI in a subset of procedures. The potential influence of age and urinary diversion type on postoperative ileus is contradictory in the literature. There is some evidence suggesting that BMI, blood loss, urinary extravasation, existence of a major complication, bowel resection, operative time and transperitoneal approach are independent risk factors for POI. Treatment of POI remains elusive. One of the most important and effective management strategies for patients undergoing radical cystectomy has been the development and use of enhanced recovery programs. An optimal rational strategy to shorten the duration of POI should incorporate minimal invasive approach when appropriate into multimodal fast track programs designed to reduce POI and shorten LOS.

  10. Urology on the internet - introduction and update

    OpenAIRE

    Inumpudi Anand; Srinivas, M.; A K Hemal

    2000-01-01

    The Internet, which has truly united the developed and developing nations, is an extensive network of inter-linked computers storing immense bytes of information, which can be accessed by anyone transcending all geographi-cal barriers and this has become the ultimate frontier to access information. The Urology and Andrology informa-tion on Internet is exponentially growing. The urologist need not know the intricacies of the hardware and soft-ware but can start right away navigating through th...

  11. Urologic manifestations of the iliacus hematoma syndrome.

    Science.gov (United States)

    Colapinto, V; Comisarow, R H

    1979-08-01

    Anticoagulated patients may have a characteristic syndrome of femoral neuropathy from an iliacus muscle hematoma. They may present with urologic signs and symptoms, including groin, flank and thigh pain, groin tenderness, an iliac fossa mass and hematuria. Urography may reveal an enlarged psoas shadow and hydronephrosis from ureteral obstruction. Prompt diagnosis is essential so that early operative decompression of the femoral nerve can be done. The urologist has an important role in the diagnosis and treatment of this syndrome.

  12. Computer- and robot-assisted urological surgery

    CERN Document Server

    Troccaz, Jocelyne

    2006-01-01

    The author reviews the computer and robotic tools available to urologists to help in diagnosis and technical procedures. The first part concerns the contribution of robotics and presents several systems at various stages of development (laboratory prototypes, systems under validation or marketed systems). The second part describes image fusion tools and navigation systems currently under development or evaluation. Several studies on computerized simulation of urological procedures are also presented.

  13. Holmium laser for multifunctional use in urology

    Science.gov (United States)

    Watson, Graham M.; Shroff, Sunil; Thomas, Robert; Kellett, Michael

    1994-05-01

    The holmium laser pulsed at 350 microsecond cuts tissue and fragments calculi. It has been assessed for minimally invasive urological intervention. It is useful for partly excising and partly coagulating tumors, incising strictures and the obstructed PUJ. It partly drill and partly fragments urinary calculi however hard. Other lasers are more effective at any one particular application, but this laser is a useful compromise as a multifunctional device.

  14. Comparison of PCBBs and CTs irradiated at 250 deg. C, 300 deg. C, and 350 deg. C

    Energy Technology Data Exchange (ETDEWEB)

    Rensman, J.; Nolles, H.N. [ECN-Energy Research Foundation, Research Unit NRG, Westerduinweg, Petten (Netherlands); Lucon, E. [SCK-CEN, Institute of Nuclear Material Science, Boeretang, Mol (Belgium); Spatig, P. [EPFL-CRDP, Centre de Recherches en Physique des Plasmas, Association Euratom-Confederation Suisse, CH Villigen PSI (Switzerland)

    2007-07-01

    Full text of publication follows: The fracture toughness of irradiated Eurofer steel is difficult to characterise. Several limitations are identified in this paper with respect to the conventional treatment of fracture data of BCC steels in the transition region. It is uncertain that the RPV Master Curve is applicable to unirradiated Eurofer, and low temperature irradiation adds more to this uncertainty. The lack of strain hardening and the dose variation within each batch are two complicating factors. An irradiation has been carried out in the BFR up to a nominal dose of 2.5 dpa at 250 deg. C, 300 deg. C, and 350 deg. C in sodium. Twelve small size pre-cracked bend specimens and eight mini-CT specimens have been irradiated in each temperature section. We analyse the effect of constraint and censoring limit, and the specimen geometry and loading configuration. The fracture data are treated in several ways that are proposed in open literature to investigate the effect of irradiation on a reference temperature like the ASTM E1921 T0. In addition, the relation between the tensile hardening, which is presented in a companion paper, and the shift calculated with the various methods is studied. (authors)

  15. Bacillus subtilis Two-Component System Sensory Kinase DegS Is Regulated by Serine Phosphorylation in Its Input Domain

    Science.gov (United States)

    Jers, Carsten; Kobir, Ahasanul; Søndergaard, Elsebeth Oline; Jensen, Peter Ruhdal; Mijakovic, Ivan

    2011-01-01

    Bacillus subtilis two-component system DegS/U is well known for the complexity of its regulation. The cytosolic sensory kinase DegS does not receive a single predominant input signal like most two-component kinases, instead it integrates a wide array of metabolic inputs that modulate its activity. The phosphorylation state of the response regulator DegU also does not confer a straightforward “on/off” response; it is fine-tuned and at different levels triggers different sub-regulons. Here we describe serine phosphorylation of the DegS sensing domain, which stimulates its kinase activity. We demonstrate that DegS phosphorylation can be carried out by at least two B. subtilis Hanks-type kinases in vitro, and this stimulates the phosphate transfer towards DegU. The consequences of this process were studied in vivo, using phosphomimetic (Ser76Asp) and non-phosphorylatable (Ser76Ala) mutants of DegS. In a number of physiological assays focused on different processes regulated by DegU, DegS S76D phosphomimetic mutant behaved like a strain with intermediate levels of DegU phosphorylation, whereas DegS S76A behaved like a strain with lower levels of DegU phophorylation. These findings suggest a link between DegS phosphorylation at serine 76 and the level of DegU phosphorylation, establishing this post-translational modification as an additional trigger for this two-component system. PMID:21304896

  16. Bacillus subtilis two-component system sensory kinase DegS is regulated by serine phosphorylation in its input domain.

    Directory of Open Access Journals (Sweden)

    Carsten Jers

    Full Text Available Bacillus subtilis two-component system DegS/U is well known for the complexity of its regulation. The cytosolic sensory kinase DegS does not receive a single predominant input signal like most two-component kinases, instead it integrates a wide array of metabolic inputs that modulate its activity. The phosphorylation state of the response regulator DegU also does not confer a straightforward "on/off" response; it is fine-tuned and at different levels triggers different sub-regulons. Here we describe serine phosphorylation of the DegS sensing domain, which stimulates its kinase activity. We demonstrate that DegS phosphorylation can be carried out by at least two B. subtilis Hanks-type kinases in vitro, and this stimulates the phosphate transfer towards DegU. The consequences of this process were studied in vivo, using phosphomimetic (Ser76Asp and non-phosphorylatable (Ser76Ala mutants of DegS. In a number of physiological assays focused on different processes regulated by DegU, DegS S76D phosphomimetic mutant behaved like a strain with intermediate levels of DegU phosphorylation, whereas DegS S76A behaved like a strain with lower levels of DegU phophorylation. These findings suggest a link between DegS phosphorylation at serine 76 and the level of DegU phosphorylation, establishing this post-translational modification as an additional trigger for this two-component system.

  17. The history of urologic surgery: from reeds to robotics.

    Science.gov (United States)

    Nahon, Irmina; Waddington, Gordon; Dorey, Grace; Adams, Roger

    2011-01-01

    Bladder function has interested man since prehistoric times. Evidence of health and well being was often measured from observation of urine. When urologic function was impaired, the extent of the ensuing pain often called for dramatic measures to obtain relief. The practice of urology has advanced substantially since the days when reeds were used to alleviate obstruction of the bladder. This article presents a brief historical overview of urology and the strides made in prostate surgery with modern technology.

  18. Prostate and Urologic Cancer | Division of Cancer Prevention

    Science.gov (United States)

    [[{"fid":"183","view_mode":"default","fields":{"format":"default","field_file_image_alt_text[und][0][value]":"Prostate and Urologic Cancer Research Group Homepage Logo","field_file_image_title_text[und][0][value]":"Prostate and Urologic Cancer Research Group Homepage Logo","field_folder[und]":"15"},"type":"media","attributes":{"alt":"Prostate and Urologic Cancer Research Group Homepage Logo","title":"Prostate and Urologic Cancer Research Group Homepage Logo","height":"266","width":"400","clas | Conducts and supports research on the prevention and early detection of prostate, bladder, and skin cancers.

  19. Looking forward, looking back-10 years in urology.

    Science.gov (United States)

    Albersen, Maarten; Cartwright, Rufus; Choyke, Peter; Goldenberg, S Larry; Goldman, Howard; Lawrentschuk, Nathan; Linehan, W Marston; Murphy, Declan; Nagler, Harris; Scardino, Peter; Shortliffe, Linda; Stenzl, Arnulf; Theodorescu, Dan

    2014-11-01

    When Nature Reviews Urology launched in 2004, the field of urology was vastly different to that which we work in today, and the past 10 years have seen the field change immensely. As a specialty on the forefront of cutting-edge innovation, urologists are often the first to embrace new technologies and ideas. In this Viewpoint, members of the Nature Reviews Urology advisory board were asked what they thought was the most important change, issue or innovation in urology in the past 10 years, and what they expected to be the most important in the next decade. Here are their opinions.

  20. The Current State of Medical Malpractice in Urology.

    Science.gov (United States)

    Sherer, Benjamin A; Coogan, Christopher L

    2015-07-01

    Medical malpractice can present an unwelcome professional, emotional, and economic burden to the practicing urologist. To date, there is a paucity of data specific to urologic malpractice in the literature. We performed a comprehensive literature search to identify and evaluate recent studies related to urologic malpractice. We also analyzed 6249 closed urologic claims from the largest available specialty-specific data set gathered by Physician Insurers Association of America from 1985 to 2012. The resulting comprehensive review seeks to raise awareness of current trends in the malpractice environment specific to urologic surgery while also helping urologists identify opportunities for risk management and improved patient care.

  1. Assessing Natural Background Levels of aquifers in the Metropolitan Area of Milan (Lombardy)

    Science.gov (United States)

    De Caro, Mattia; Crosta, Giovanni; Frattini, Paolo

    2016-04-01

    The European Water Framework Directive (WFD 2000/60/CE) requires Member States to evaluate the status of groundwater bodies in order to reach a good water quality for human consumption. One of the preliminary steps for defining the status of groundwater bodies consists in the definition and evaluation of the so-called Natural Background Levels (NBL). The NBL or Baseline level can be defined as "the range of concentration of a given element, isotope or chemical compound in solution, derived entirely from natural, geological, biological or atmospheric sources, under conditions not perturbed by anthropogenic activity" (Edmund and Shand, 2009). The qualitative analysis for a large area (ca 4500 Km2) of the Po Plain around the Milan Metropolitan area (Lombardy, Italy) is presented in this study. Despite the aquifers in the Milan metropolitan area are an incredible groundwater resource for a very large population (3.195.629 inhabitants in the metropolitan area, data at November 2014) and a highly industrialized area, a groundwater baseline characterization is still missing. In order to attain the hydro-geochemical characterization a complete geodatabase was built (120.655 chemical samples from 1980 to 2014). This database has been explored by classical and multivariate statistical analyses to provide relationships among the more influential lithological, hydrogeological and hydro-chemical variables. Finally, the NBLs of different chemical species which may be anthropogenic sensitive (Na, Cl, K, NO3, SO4, NH4, As, Fe, Cr, Fe, Mn, Zn) and for multiple aquifer bodies (phreatic, semi-confined and confined aquifer) are evaluated. Two different approaches are applied: the Pre-Selection method (BRIDGE, 2006) and the Component-Separation method. The first one (PS) consists in the exclusion of samples from the available dataset that could indicate human activities then deriving the NBL as the 90th percentile of the remaining data. The second one (CS) consists in the fitting of

  2. Urological disorders and pregnancy: An overall experience

    Directory of Open Access Journals (Sweden)

    Debasmita Mandal

    2017-01-01

    Full Text Available Aim: Pregnancy is an anatomical and physiological altered state and the presence of various urological problems not only aggravates the disease itself, but also results in unfavourable pregnancy outcome. Aim is to highlight obstetric outcome in pregnant women with urological problems. Materials and Methods: Longitudinal prospective cohort study conducted in tertiary care hospital, IPGME and R, Kolkata from Jan 2011 to Dec 2012. All pregnant women with urological problems were included as subjects. Results: A total of 33 subjects were followed up throughout their antenatal period. Among them majority (72.72% presented with hydro nephrosis followed by hydroureter (60.6%, PUJ obstruction and pyelonephritis each with incidence of 15.15%, then urolithiasis (12.12%, nephrolithiasis (6.06% and renal abscess (12.12%. Interventions required were DJ stenting (72.72%, pyeloplasty (15.15% and others were RURSL, abscess drainage and ATT. The pregnancy outcome was complicated with preterm labor in majority of patients (45.45%, oligohydramnious (18.18%, PIH (9.09% and still birth (6.06%. Twenty four live birth were there. Majority required NICU admissions as predominantly prematurity was an important concern. Majority women with hydronephrosis underwent DJ stenting. Conclusion: Preterm labor is an important obstetric concern. Vaginal delivery is the choicest mode of termination and LSCS can be reserved for obstetric reason. DJ stenting is safe and practical approach for continuation of pregnancy with hydronephrosis. Regular follow up, vigilant antenatal care and multidisciplinary approach from urologist, obstetrician and neonatologist will bring out successful pregnancy outcome.

  3. Urological disorders and pregnancy: An overall experience

    Science.gov (United States)

    Mandal, Debasmita; Saha, Mriganka Mouli; Pal, Dillip Kumar

    2017-01-01

    Aim: Pregnancy is an anatomical and physiological altered state and the presence of various urological problems not only aggravates the disease itself, but also results in unfavourable pregnancy outcome. Aim is to highlight obstetric outcome in pregnant women with urological problems. Materials and Methods: Longitudinal prospective cohort study conducted in tertiary care hospital, IPGME and R, Kolkata from Jan 2011 to Dec 2012. All pregnant women with urological problems were included as subjects. Results: A total of 33 subjects were followed up throughout their antenatal period. Among them majority (72.72%) presented with hydro nephrosis followed by hydroureter (60.6%), PUJ obstruction and pyelonephritis each with incidence of 15.15%, then urolithiasis (12.12%), nephrolithiasis (6.06%) and renal abscess (12.12%). Interventions required were DJ stenting (72.72%), pyeloplasty (15.15%) and others were RURSL, abscess drainage and ATT. The pregnancy outcome was complicated with preterm labor in majority of patients (45.45%), oligohydramnious (18.18%), PIH (9.09%) and still birth (6.06%). Twenty four live birth were there. Majority required NICU admissions as predominantly prematurity was an important concern. Majority women with hydronephrosis underwent DJ stenting. Conclusion: Preterm labor is an important obstetric concern. Vaginal delivery is the choicest mode of termination and LSCS can be reserved for obstetric reason. DJ stenting is safe and practical approach for continuation of pregnancy with hydronephrosis. Regular follow up, vigilant antenatal care and multidisciplinary approach from urologist, obstetrician and neonatologist will bring out successful pregnancy outcome. PMID:28216926

  4. [From paediatric urological care to adult urology. Assessment of a transition consultation for adolescents].

    Science.gov (United States)

    Even, L; Mouttalib, S; Moscovici, J; Soulie, M; Rischmann, P; Game, X; Galinier, P; Bouali, O

    2017-10-01

    To provide an adequate lifelong urological care in the complex period of adolescence, a transition consultation conducted by a paediatric surgeon and an urologist was developed in our institution. As a real rite of passage, it allows the follow-up and the adapted care of urological conditions, sometimes complex, and permits the transition between childhood and the world of grown-ups. We reported our experience at the Children Hospital of our institution (paediatric surgery and urology departments). During a 6 months period (January-July 2015), forty-five young adults with a mean age of 17.8±3.6 years were seen in transition consultation. Eight patients had neurogenic voiding disorders (4 spina bifida, 1 multiple sclerosis, 1 mitochondrial encephalopathy, 1 metachromic leucodystrophy, 1 paraplegia), 9 patients had idiopathic voiding disorders, 1 patient had a non obstructive malformative uropathy; and 30 patients had surgery during infancy and childhood: hypospadias in 17 young men and malformative uropathy in 13 patients. This consultation occurred within 4.6±4.5 years after the last consultation with paediatric surgeon. For 6 patients, the transition consultation was the first for the urological problem. After this consultation, 8 patients stayed in paediatric surgery and 37 patients were referred to adult urologist. Among those 8 patients: 2 patients had cognitive and psychiatric disorders; 4 patients refused to be transferred to adult unit; 2 patients wanted to come back at transition consultation. Among the 37 patients transferred in adult urological care: 6 patients had urological surgery, and one patient was referred to a sexology consultation. The remaining 30 patients have initiated long-term monitoring. All reconvened patients came back at the follow-up visit (at least 12 months follow-up). A 16-year-old patient (spina bifida with polymalformative syndrome) developed a depressive syndrome at the end of the consultation, in the motive of an awareness of

  5. Iatrogenic urological triggers of autonomic dysreflexia

    DEFF Research Database (Denmark)

    Liu, N; Zhou, M; Biering-Sørensen, F

    2015-01-01

    Med search using AD/ autonomic hyperreflexia and spinal cord injury (SCI). Studies selected for review involved iatrogenic urological triggers of AD in individuals with SCI, including original articles, previous practice guidelines, case reports and literature reviews. Studies that did not report AD or blood...... dyssynergia. Without anesthesia, the majority of individuals develop AD during cystoscopy, transurethral litholapaxy and ESWL. The effectiveness of different anesthesia methods relies on blocking the nociceptive signals from the lower urinary tract (LUT) below the level of the neurological lesion. Other...

  6. [German Urological Associations under National Socialism].

    Science.gov (United States)

    Krischel, M; Moll, F; Fangerau, H

    2011-09-01

    The Deutsche Gesellschaft für Urologie (German Urological Association), established in 1907, was a German-Austrian medical society in which Jewish physicians held important positions. When the Nazis seized power in 1933, the Austrian Hans Rubritius was president of the society. The non-German presidency and the exclusion of Jewish colleagues from the professional society and medical practice led to a halt of the society's activities. At the same time in the mid 1930s, German urologists founded the Gesellschaft Reichsdeutscher Urologen (Association of Reichs-German Urologists) whose members aligned themselves with Nazi health policies and in turn received professional and personal benefits.

  7. [Management of brain metastases from urological malignancies].

    Science.gov (United States)

    Gaillard, S; Lebret, T; Scarone, P; Lepeintre, J-F; Méjean, A; Aldea, S

    2008-11-01

    Brain metastases account for 30 to 40% of all brain tumors in adults. Even if urological carcinomas are not very common, anti-angiogenic drugs have transformed their prognosis, leading physicians to consider their specific treatment. For the majority of cases, surgery is quite simple with low associated morbidity. Depending on the size and the location, surgery or stereotaxic radiotherapy should be discussed. As soon as the metastasis is suspected a neurosurgerical opinion must be sought before beginning any treatment to coordinate the global management.

  8. OCCURRENCE OF LISTERIA MONOCYTOGENES IN READY TO EAT FOOD SAMPLES COLLECTED BY LOMBARDY REGION HEALTH AUTHORITIES IN 2009-2010

    Directory of Open Access Journals (Sweden)

    E. Oliverio

    2012-08-01

    Full Text Available The study provides data on the prevalence of Listeria monocytogenes in ready-to-eat food samples collected by Lombardy region health authorities and analyzed by Department of Food Microbiology, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna. From the total of 503 food samples analyzed, the pathogen was detected in 85 (16,9%. In particular it was highlighted in 8/152 (5,3% meat products, in 5/245 (2% dairy products and in 42/106 (39,6% fishery products. Given the considerable public health implications, the study confirms that a well-planned program of listeriosis surveillance should be enforced to suitably estimate the burden of disease and to prevent foodborne outbreaks.

  9. Management of pelvic fractures with concomitant urologic injuries.

    Science.gov (United States)

    Taffet, R

    1997-07-01

    Controversy exists regarding the management of pelvic fractures with concomitant injuries to the lower urologic tract. This can be seen in both the urologic and orthopedic literature as it pertains to the ideal form of treatment for either problem and the timing of surgical intervention, if it is needed. This article reviews the anatomy, mechanism of injury, diagnostic approach, and treatment.

  10. Prevalence of Sexual Abuse among Patients Seeking General Urological Care

    NARCIS (Netherlands)

    Beck, Jack J. H.; Bekker, Milou D.; van Driel, Mels F.; Roshani, Hossein; Putter, Hein; Pelger, Rob C. M.; Elzevier, Henk W.

    2011-01-01

    Introduction. Sexual abuse (SA) history can be found in the backgrounds of an important fraction of men (8-10%) and women (12-25%). Until now there are no data about this prevalence within a urological patient population. Aim. To establish the prevalence of SA among men and women visiting a urologic

  11. 21 CFR 876.5130 - Urological catheter and accessories.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Urological catheter and accessories. 876.5130 Section 876.5130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Therapeutic Devices § 876.5130...

  12. [The William P. Didusch Center for Urologic History of the American Urological Association: new exciting approaches in presenting urologic history, not only in the USA - a personal guided tour].

    Science.gov (United States)

    Engel, R M

    2011-04-01

    The Didusch Center for Urologic History encompasses a rich and varied collection of drawings, photographs, and instruments of historical importance to urology, many displayed in the urological exhibits during the American Urological Association (AUA) conventions. The Center also houses a library devoted to urological and early medical texts and the AUA archives and is the institution of research in all fields of urologic history in the USA. The museum collection features most of Didusch's original drawings, as well as an impressive instrument collection acquired primarily through donations by urologists. The original William P. Didusch Museum (now known as the William P. Didusch Center for Urologic History) was originally housed in the AUA's Baltimore City headquarters building. Upon the association's move to Linthicum, MD in 2003, the museum has evolved into the William P. Didusch Center for Urologic History and taken on new tasks and responsibilities that include the topic of research in urologic history.

  13. Emerging role of robotics in urology

    Directory of Open Access Journals (Sweden)

    Kumar Rajeev

    2005-01-01

    Full Text Available Robotic assistance is one of the latest additions to the field of laparoscopic surgery. The most commonly used robotic device in Urology is the da Vinci ® system of which over 200 devices are installed worldwide including 3 in India. This robot consists of three or four arms, one of which is used to hold and manipulate the laparoscopic camera while the others are used to manipulate specialized laparoscopic instruments with endowrist ® technology that allows 7 degrees of freedom. The robot is currently used primarily for radical prostatectomies where complex dissection and reconstruction can be performed in less than 2 hours with excellent outcomes. There is a progressive increase in the number of surgeries being performed by this device which allows laparoscopy naοve surgeons to offer the benefits of minimally invasive surgery to their patients. The other surgeries where this device has been used to benefit are pyeloplasty, cystectomy with urinary diversion, nephrectomy and ureteric re-implant. The principal drawbacks of the device are the steep cost of machine and disposables. However, the benefits achieved in terms of improved surgical precision, magnified 3 dimensional vision, scaling of movements, remote surgery and as a teaching tools will help the robot establish a definitive place in the urologic armamentarium.

  14. [Contribution to the history of urological pharmacotherapy].

    Science.gov (United States)

    Mercant, J

    2011-02-01

    The aim of this work is to present a historical review of urological pharmacotherapy. The containers used to preserve and store medicines are an important source of information in historical research. I studied written sources such as treaties of Medical and Therapeutical Materials, as well as material sources available at the Pharmacy Museum of the Farmacia Monástica de la Real Cartuja de Valldemossa in Mallorca. I examined the old medicine containers and the labelling on ceramic recipients, glass jars and wooden boxes and other medicines found inside them. Different medicines, the most used over the centuries to treat diseases of the urinary system are described, including both simple (of plant, mineral or animal origin) and compound medicines: drumstick tree, agaricus, mechoacan, lupine, fennel, acacia gum, myrtle, Armenian bole, oleum scorpionum, hartshorn plantain, cantharides. I present evidence of knowledge available for each of these remedies in the main bibliographic sources, as well as proof that they were used in Valldemossa. The basis of general and urological pharmacotherapy was concentrated on nature. Medicines of plant origin were the most used. The therapeutic inventory that mankind has accumulated throughout history is the result of a lengthy process of combining practices and knowledge of different cultures and societies. Copyright © 2010 AEU. Published by Elsevier Espana. All rights reserved.

  15. Integrated visualization of problemcentric urologic patient records.

    Science.gov (United States)

    Bui, Aleex A T; Taira, Ricky K; Churchill, Bernard; Kangarloo, Hooshang

    2002-12-01

    The collision of computer-based technologies and the medical environment is resulting in an increasingly electronic multimedia patient record, consisting of not only the traditional types of data (e.g., clinic notes and laboratory reports), but also digital images (e.g., computed tomography and magnetic resonance imaging) and other visual representations of patient data (e.g., pulmonary function graphs and urodynamic charts). Given the increasing amount of data made available to physicians, it is not only critical that the totality of a patient's medical record be accessible to a clinician, but that the diverse data be integrated and presented in a manner conducive to patient management: key information should be easily discovered. This paper describes a problemcentric time-based visualization of urologic conditions, whereby a patient's medical history is automatically organized around a medical problem and presented as a graphic chronology. Urology-related data in the patient medical record is organized in accord with an expert constructed knowledge-base, and plotted on a timeline using iconic representations. The user interface permits the physician to quickly view multimedia data and to visualize relationships between events in the patient's history.

  16. Current status of laser applications in urology

    Science.gov (United States)

    Knipper, Ansgar; Thomas, Stephen; Durek, C.; Jocham, Dieter

    1993-05-01

    The overall development of laser use in urology is recessing. The reasons are the refinement of methods of radical surgery and the continuing development of alternative technologies involving electric current. Taking the cost factor into account, are lasers still opportune in medicine? The answer is definitely yes. Cost reduction in medical practice without quality loss is only possible with effective methods of minimally invasive surgery. Continuing investigation of cutting, welding, coagulating and ablating instruments is justified. Competition of lasers to other technologies can only be beneficial to the cause. But where are the highlights of laser applications? The unsurpassed utilization of optical properties of lasers lie in the concept of photodynamic therapies and in optical feedback mechanisms for laser applications. The combination of lasers with three dimensional visualization of the treatment area by ultrasound (TULIP-procedure for benign prostatic hyperplasia) is a novel approach in laser application. The further development of these treatment modalities will reveal the true benefit of laser technology in urological applications.

  17. EAU standardised medical terminology for urologic imaging: a taxonomic approach.

    Science.gov (United States)

    Loch, Tillmann; Carey, Brendan; Walz, Jochen; Fulgham, Pat Fox

    2015-05-01

    The terminology and abbreviations used in urologic imaging have generally been adopted on an ad hoc basis by different speciality groups; however, there is a need for shared nomenclature to facilitate clinical communication and collaborative research. This work reviews the current nomenclature for urologic imaging used in clinical practice and proposes a taxonomy and terminology for urologic imaging studies. A list of terms used in urologic imaging were compiled from guidelines published by the European Association of Urology and the American Urological Association and from the American College of Radiology Appropriateness Criteria. Terms searched were grouped into broad categories based on technology, and imaging terms were further stratified based on the anatomic extent, contrast or phases, technique or modifiers, and combinations or fusions. Terms that had a high degree of utilisation were classified as accepted. We propose a new taxonomy to define a more useful and acceptable nomenclature model acceptable to all health professionals involved in urology. The major advantage of a taxonomic approach to the classification of urologic imaging studies is that it provides a flexible framework for classifying the modifications of current imaging modalities and allows the incorporation of new imaging modalities. The adoption of this hierarchical classification model ranging from the most general to the most detailed descriptions should facilitate hierarchical searches of the medical literature using both general and specific terms. This work is limited in its scope, as it is not currently all-inclusive. This will hopefully be addressed by future modification as others embrace the concept and work towards uniformity in nomenclature. This paper provides a noncomprehensive list of the most widely used terms across different specialties. This list can be used as the basis for further discussion, development, and enhancement. In this paper we describe a classification system

  18. Global map of lithosphere thermal thickness on a 1 deg x 1 deg grid - digitally available

    DEFF Research Database (Denmark)

    Artemieva, Irina

    2014-01-01

    than 250 km) lithosphere is restrictedsolely to young Archean terranes (3.0–2.6 Ga), while in old Archean cratons (3.6–3.0 Ga) lithospheric roots donot extend deeper than 200–220 km.The TC1 model is presented by a set of maps, which show significant thermal heterogeneity within continentalupper mantle......This presentation reports a 1 deg 1 deg global thermal model for the continental lithosphere (TC1). The modelis digitally available from the author’s web-site: www.lithosphere.info.Geotherms for continental terranes of different ages (early Archean to present) are constrained by reliabledata...

  19. Bacillus subtilis Two-Component System Sensory Kinase DegS Is Regulated by Serine Phosphorylation in Its Input Domain

    DEFF Research Database (Denmark)

    Jers, Carsten; Kobir, Ahasanul; Søndergaard, Elsebeth Oline;

    2011-01-01

    Bacillus subtilis two-component system DegS/U is well known for the complexity of its regulation. The cytosolic sensory kinase DegS does not receive a single predominant input signal like most two-component kinases, instead it integrates a wide array of metabolic inputs that modulate its activity...

  20. [The demographic development in Germany : challenge and chances for urology].

    Science.gov (United States)

    Schneider, A W; Fichtner, J

    2014-08-01

    Urology is affected by the demographic development in Germany more than any other medical discipline. Despite a relatively stable total population, by the year 2040 there will be an absolute and relevant increase in urological diseases caused only by the demographic development in the population. This is particularly true for the increase in oncological treatment just in the field of the discipline of urology. Even now the current numbers for tumor development in Germany (RKI 2014) in the urological oncology segment of all tumor diseases show an increasing trend with more than 23 %. This significant increase in performance is in contrast to the age development of the specialists in this discipline. In total but especially due to the significantly over-aged specialist medical profession in urology, this leads to a substantial bottleneck of specialists in the discipline of urology. This deficiency of personnel resources in urology is aggravated by the requirements of Generation Y for a well-adjusted work-life balance and the associated feminization of the medical profession. This requires intelligent strategies for.

  1. How to develop a simulation programme in urology.

    Science.gov (United States)

    Ahmed, Kamran; Amer, Tarik; Challacombe, Ben; Jaye, Peter; Dasgupta, Prokar; Khan, Mohammad Shamim

    2011-12-01

    What's known on the subject? and What does the study add? Inanimate trainers and simulators have been shown to facilitate the skill acquisition of urologists. However, there are significant challenges to integrating standalone simulation programmes into mainstream urology curricula. This study provides a framework to overcome these challenges and discusses the advantages of centralised urology simulation centres and their potential to serve as key adjuncts in the certification and validation process of urologists. Fixed performance-based outcomes of inanimate trainers and simulators have been praised as useful adjuncts in urology for reducing the learning curve associated with the acquisition of new technical and non-technical skills without compromising patient safety. Simulators are becoming an integral part of the urology training curriculum and their effectiveness is totally dependent on the structure of the programme implemented. The present paper discusses the fundamental concepts of centralized urology centres and their potential to serve as key adjuncts in the certification and validation process of urologists. In summary, proficiency-based curricula with well structured endpoints and objective tools for validating proficiency are critical in developing a simulation programme in urology. We concludes that more educational research into the outcomes of integrated urology curricula followed by trainee/trainer opinion surveys will help address some of these criteria.

  2. The use of smartphone applications by urology trainees.

    Science.gov (United States)

    Nason, G J; Burke, M J; Aslam, A; Kelly, M E; Akram, C M; Giri, S K; Flood, H D

    2015-10-01

    Mobile phone technology is continuously advancing- the smartphone allows users instant access to information via the internet. Downloadable applications (apps) are becoming widespread across medical specialities. The aim of this study was to assess the use of smartphone apps among urology trainees in Ireland. An anonymous electronic survey was distributed via Survey Monkey(®) to all urology trainees in Ireland assessing their ownership and use of smartphones and downloadable apps. A search of urology apps was performed using the Apple App Store and the Android Market. 36 (81.8%) of trainees responded with 100% ownership of smartphones. 28 (77%) report downloading apps with 11 (30.6%) reporting paying for them. The mean number of apps downloaded was 4 (Range 1-12). 16 (44.4%) trainees think apps for smartphones are very useful in clinical practice, 14 (42.4%) think they are useful. A total of 126 urology apps were available. 76 (60.3%) were designed for physicians, 46 (36.5%) for patients, 2 (1.6%) for students and 2 (1.6%) for urological nurses. There are an ever increasing number of urology apps available. Urology trainees are using smartphones as an educational and reference tool and find them a useful aide in clinical practice. Copyright © 2014 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.

  3. Use of social media in urology: data from the American Urological Association (AUA).

    Science.gov (United States)

    Loeb, Stacy; Bayne, Christopher E; Frey, Christine; Davies, Benjamin J; Averch, Timothy D; Woo, Henry H; Stork, Brian; Cooperberg, Matthew R; Eggener, Scott E

    2014-06-01

    To characterise the use of social media among members of the American Urological Association (AUA), as the use of social media in medicine has greatly expanded in recent years. In December 2012 to January 2013, the AUA e-mailed a survey with 34 questions on social media use to 2000 randomly selected urologists and 2047 resident/fellow members. Additional data was collected from Symplur analytics on social media use surrounding the AUA Annual Meeting in May 2013. In all, 382 (9.4%) surveys were completed, indicating 74% of responders had an online social media account. The most commonly used social media platforms were Facebook (93%), followed in descending order by LinkedIn (46%), Twitter (36%) and Google+ (26%). Being aged social media use (83% vs 56%), with greater uptake among residents/fellows compared with attendings (86% vs 66%). Only 28% of respondents used social media partly or entirely for professional purposes. During the 2013 AUA Annual Meeting, there were >5000 tweets from >600 distinct contributors. As of early 2013, among respondents to an e-mail survey, most urologists and urology trainees used some form of social media, and its use in urology conferences has greatly expanded. © 2013 The Authors. BJU International © 2013 BJU International.

  4. Angiopatia diabetica e amputazione degli arti inferiori: valutazioni preliminari degli episodi di ricovero ripetuti

    Directory of Open Access Journals (Sweden)

    P. Trerotoli

    2003-05-01

    Full Text Available

    Obiettivi: l’obiettivo principale dello studio è stata la valutazione dei ricoveri ripetuti nei soggetti con vasculopatia diabetica, rispetto ai soggetti con vasculopatia non diabetica.

    Materiali e Metodi: sono state selezionate le SDO del triennio 1998-2000 contenenti, in uno dei campi di diagnosi, i codici di diabete mellito, con e senza complicanze (codici ICD9 ed ICD9CM, 250.—, vasculopatia periferica (440.2 e 440.8, ulcera periferica (707.1, 707.8, 707.9, gangrena (785.4. Le SDO con diagnosi di vasculopatia diabetica sono state considerate come angiopatie diabetiche (AD; le altre sono state attribuite agli angiopatici non diabetici (AND. Le SDO con diabete non complicato e arteriopatia periferica sono state eliminate. L’intervento di amputazione è stato individuato dalla presenza del codice ICD9CM di procedura 84.—. La ripetitività degli episodi è stata valutata usando il codice fiscale come identificativo del paziente. Risultati: sono state rilevate 5814 dimissioni di AD e 9010 di AND. Le amputazioni sono state 285 (4,90% negli AD e 485 (5,38% negli AND. I ricoveri ripetuti sono stati 13 negli AD e 12 negli AND. Le amputazioni sono state osservate verso il 4°-5° episodio di ricovero negli AD, mentre già dal 2° episodio negli AND. Le ulcere erano presenti nel 36,05% (il 36,5% nel primo episodio di ricovero, che resta costante negli episodi successivi degli AND e nel 10,97% degli AD (9,84% nel primo episodio, con un incremento fino al 20% del 5° episodio. Un episodio in day-hospital (DH si osserva nel 12,32% degli AD, contro il 4,20% degli AND.

    Conclusioni: l’accesso degli AD all’assistenza intraospedaliera avviene più frequentemente in DH, i passi successivi sono caratterizzati dalla comparsa dell’ulcera o gangrena e infine dall’amputazione. Nel gruppo degli AD è stato osservato un eccesso di ospedalizzazione, probabilmente per ripetitività del

  5. Use of Botulinum Toxin in Urologic Diseases.

    Science.gov (United States)

    Chermansky, Christopher J; Chancellor, Michael B

    2016-05-01

    OnabotulinumtoxinA (onaBoNTA) is approved by the US Food and Drug Administration for the treatment of urinary incontinence due to neurogenic detrusor overactivity and for the treatment of refractory overactive bladder. As a treatment for benign prostatic hyperplasia, onaBoNTA showed no difference over placebo in recently published studies. In contrast, treating interstitial cystitis/bladder pain syndrome with onaBoNTA has shown efficacy, and the current American Urological Association guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome lists onaBoNTA as fourth-line treatment. This comprehensive review will present all studied applications of onaBoNTA within the lower urinary tract.

  6. Urological aspects of HIV and AIDS.

    Science.gov (United States)

    Heyns, Chris F; Smit, Shaun G; van der Merwe, André; Zarrabi, Amir D

    2013-12-01

    The use of highly active antiretroviral therapy (HAART) in HIV-infected people has led to a dramatic decrease in the incidence of opportunistic infections and virus-related malignancies such as non-Hodgkin lymphoma and Kaposi sarcoma, but not cervical or anal cancer. Advanced-stage cervical cancer is associated with a high incidence of urological complications such as hydronephrosis, renal failure, and vesicovaginal fistula. Adult male circumcison can significantly reduce the risk of male HIV acquisition. Although HAART does not completely eradicate HIV, compliance with medication increases life expectancy. HIV infection or treatment can result in renal failure, which can be managed with dialysis and transplantation (as for HIV-negative patients). Although treatment for erectile dysfunction--including phosphodiesterase 5 inhibitors, intracavernosal injection therapy, and penile prosthesis--can increase the risk of HIV transmission, treatment decisions for men with erectile dysfunction should not be determined by HIV status. The challenges faced when administering chemotherapy to HIV-infected patients with cancer include late presentation, immunodeficiency, drug interactions, and adverse effects associated with compounded medications. Nonetheless, HIV-infected patients should receive the same cancer treatment as HIV-negative patients. The urologist is increasingly likely to encounter HIV-positive patients who present with the same urological problems as the general population, because HAART confers a prolonged life expectancy. Performing surgery in an HIV-infected individual raises safety issues for both the patient (if severely immunocompromised) and the surgeon, but the risk of HIV transmission from patients on fully suppressive HAART is small.

  7. CIRCULATION AU MOYEN AGE DES MATERIAUX FERREUX ISSUS DES PYRENEES ARIEGEOISES ET DE LA LOMBARDIE. APPORT DU COUPLAGE DES ANALYSES EN ELEMENTS TRACES ET MULTIVARIEES.

    OpenAIRE

    Leroy, Stéphanie

    2010-01-01

    This provenance study concerns the trade understanding in the Middle Ages of iron objects originally from specific ironmaking processes linked to the use of manganese rich ores. We were particularly interested in the case studies of the Ariège (French Pyrenees) and the Lombardy (Italian Alps) areas, two separate geographic areas that held a major place in the medieval economy of their region. This work deals with three specific historical questions. The first part is to clarify the trade rout...

  8. Surveillance of acute flaccid paralysis (AFP) in Lombardy, Northern Italy, from 1997 to 2011 in the context of the national AFP surveillance system.

    Science.gov (United States)

    Pellegrinelli, Laura; Primache, Valeria; Fiore, Lucia; Amato, Concetta; Fiore, Stefano; Bubba, Laura; Pariani, Elena; Amendola, Antonella; Barbi, Maria; Binda, Sandro

    2015-01-01

    An Acute Flaccid Paralysis (AFP) surveillance system was set up in Lombardy (Northern Italy) in 1997 in the framework of the national AFP surveillance system, as part of the polio eradication initiative by the World Health Organization (WHO). This surveillance system can now be used to detect Poliovirus (PV) reintroductions from endemic countries. This study aimed at describing the results of the AFP surveillance in Lombardy, from 1997 to 2011.   Overall, 131 AFP cases in Lombardy were reported with a mean annual incidence rate of 0.7/100 000 children AFP cases was typical with peaks in November, in January, and in March. The major clinical diagnoses associated with AFP were Guillain-Barré Syndrome (GBS, 40%) and encephalomyelitis/myelitis (13%). According to the virological results, no poliomyelitis cases were caused by wild PV infections, but two Vaccine-Associated Paralytic Paralysis (VAPP) cases were reported in 1997 when the Sabin oral polio vaccine (OPV) was still being administered in Italy. Since a surveillance system is deemed sensitive if at least one case of AFP per 100,000 children <15 years of age is detected each year, our surveillance system needs some improvement and must be maintained until global poliovirus eradication will be declared.

  9. The Global Prevalence of Infections in Urology Study: A Long-Term, Worldwide Surveillance Study on Urological Infections

    Directory of Open Access Journals (Sweden)

    Florian Wagenlehner

    2016-01-01

    Full Text Available The Global Prevalence of Infections in Urology (GPIU study is a worldwide-performed point prevalence study intended to create surveillance data on antibiotic resistance, type of urogenital infections, risk factors and data on antibiotic consumption, specifically in patients at urological departments with healthcare-associated urogenital infections (HAUTI. Investigators registered data through a web-based application (http://gpiu.esiu.org/. Data collection includes the practice and characteristics of the hospital and urology ward. On a certain day in November, each year, all urological patients present in the urological department at 8:00 a.m. are screened for HAUTI encompassing their full hospital course from admission to discharge. Apart from the GPIU main study, several side studies are taking place, dealing with transurethral resection of the prostate, prostate biopsy, as well as urosepsis. The GPIU study has been annually performed since 2003. Eight-hundred fifty-six urology units from 70 countries have participated so far, including 27,542 patients. A proxy for antibiotic consumption is reflected by the application rates used for antibiotic prophylaxis for urological interventions. Resistance rates of most uropathogens against antibiotics were high, especially with a note of multidrug resistance. The severity of HAUTI is also increasing, 25% being urosepsis in recent years.

  10. The Global Prevalence of Infections in Urology Study: A Long-Term, Worldwide Surveillance Study on Urological Infections

    Science.gov (United States)

    Wagenlehner, Florian; Tandogdu, Zafer; Bartoletti, Riccardo; Cai, Tommaso; Cek, Mete; Kulchavenya, Ekaterina; Köves, Béla; Naber, Kurt; Perepanova, Tamara; Tenke, Peter; Wullt, Björn; Bogenhard, Florian; Johansen, Truls Erik Bjerklund

    2016-01-01

    The Global Prevalence of Infections in Urology (GPIU) study is a worldwide-performed point prevalence study intended to create surveillance data on antibiotic resistance, type of urogenital infections, risk factors and data on antibiotic consumption, specifically in patients at urological departments with healthcare-associated urogenital infections (HAUTI). Investigators registered data through a web-based application (http://gpiu.esiu.org/). Data collection includes the practice and characteristics of the hospital and urology ward. On a certain day in November, each year, all urological patients present in the urological department at 8:00 a.m. are screened for HAUTI encompassing their full hospital course from admission to discharge. Apart from the GPIU main study, several side studies are taking place, dealing with transurethral resection of the prostate, prostate biopsy, as well as urosepsis. The GPIU study has been annually performed since 2003. Eight-hundred fifty-six urology units from 70 countries have participated so far, including 27,542 patients. A proxy for antibiotic consumption is reflected by the application rates used for antibiotic prophylaxis for urological interventions. Resistance rates of most uropathogens against antibiotics were high, especially with a note of multidrug resistance. The severity of HAUTI is also increasing, 25% being urosepsis in recent years. PMID:26797640

  11. Global map of lithosphere thermal thickness on a 1 deg x 1 deg grid - digitally available

    Science.gov (United States)

    Artemieva, Irina

    2014-05-01

    This presentation reports a 1 deg ×1 deg global thermal model for the continental lithosphere (TC1). The model is digitally available from the author's web-site: www.lithosphere.info. Geotherms for continental terranes of different ages (early Archean to present) are constrained by reliable data on borehole heat flow measurements (Artemieva and Mooney, 2001), checked with the original publications for data quality, and corrected for paleo-temperature effects where needed. These data are supplemented by cratonic geotherms based on xenolith data. Since heat flow measurements cover not more than half of the continents, the remaining areas (ca. 60% of the continents) are filled by the statistical numbers derived from the thermal model constrained by borehole data. Continental geotherms are statistically analyzed as a function of age and are used to estimate lithospheric temperatures in continental regions with no or low quality heat flow data. This analysis requires knowledge of lithosphere age globally. A compilation of tectono-thermal ages of lithospheric terranes on a 1 deg × 1 deg grid forms the basis for the statistical analysis. It shows that, statistically, lithospheric thermal thickness z (in km) depends on tectono-thermal age t (in Ma) as: z=0.04t+93.6. This relationship formed the basis for a global thermal model of the continental lithosphere (TC1). Statistical analysis of continental geotherms also reveals that this relationship holds for the Archean cratons in general, but not in detail. Particularly, thick (more than 250 km) lithosphere is restricted solely to young Archean terranes (3.0-2.6 Ga), while in old Archean cratons (3.6-3.0 Ga) lithospheric roots do not extend deeper than 200-220 km. The TC1 model is presented by a set of maps, which show significant thermal heterogeneity within continental upper mantle. The strongest lateral temperature variations (as large as 800 deg C) are typical of the shallow mantle (depth less than 100 km). A map of the

  12. Spanish adaptation of the recommendations for the appropriate use of social networks in urology of the European Association of Urology.

    Science.gov (United States)

    Rodríguez-Socarrás, M E; Gómez-Rivas, J; Álvarez-Maestro, M; Tortolero, L; Ribal, M J; Garcia Sanz, M; Roupret, M

    2016-09-01

    To adapt to Spanish the recommendations for the appropriate use of social media (SoMe) in the urological setting prepared by the European Association of Urology (EAU). The use of SoMe has become fairly popular in the international urological community. Due to the nature of the medical content shared among healthcare professionals through SoMe, however, there is the risk of medical and legal problems. For this reason, various international urological associations such as the American Urological Association, the British Association of Urological Surgeons and EAU have published their recommendations for the appropriate use of social media. Efforts have been made to adapt and summarise the recommendations of the EAU in Spanish and to publish them in Actas Urológicas Españolas (@actasurologicas), the official journal of the Spanish Urological Association (@InfoAEU) and the American Confederation of Urology (@CAU_URO). SoMe include well-known platforms such as Twitter, Facebook and YouTube, which have undoubtedly changed the way in which people communicate and interact. SoMe offer clear advantages for communicating between professionals, working in teams, disseminating knowledge and creating professional profiles and are increasingly used by patients and healthcare practitioners. The introduction of SoMe in the urological community has started a revolution in how scientific articles are shared, how people participate in congresses and how international urological associations communicate with their followers. However, SoMe is generally an open public setting, with potential risks for confidentiality and the doctor-patient relationship due to the nature of the shared information. The present recommendations include tools for creating professional profiles, protecting confidentiality and creating honest and responsible content. SoMe represents a fascinating area for the communication and dissemination of knowledge, with considerable applicability in health care and the

  13. [William P. Didusch. Pioneer of modern scientific illustrations for visualization in urology].

    Science.gov (United States)

    Görgen, A; Moll, F H; Engel, R; Fangerau, H

    2010-06-01

    Bill Didusch was one of the most influential illustrators in American urology. His biography is of great importance not only because of his artistic achievements, but also the work he has accomplished in the service of the American Urological Association. He founded a museum of urological artifacts that bears his name. The article reflects Didusch's biography and emphasizes his impact on American urology and urological illustration as an integral part of visualisation in medicine.

  14. Applications of three-dimensional printing technology in urological practice.

    Science.gov (United States)

    Youssef, Ramy F; Spradling, Kyle; Yoon, Renai; Dolan, Benjamin; Chamberlin, Joshua; Okhunov, Zhamshid; Clayman, Ralph; Landman, Jaime

    2015-11-01

    A rapid expansion in the medical applications of three-dimensional (3D)-printing technology has been seen in recent years. This technology is capable of manufacturing low-cost and customisable surgical devices, 3D models for use in preoperative planning and surgical education, and fabricated biomaterials. While several studies have suggested 3D printers may be a useful and cost-effective tool in urological practice, few studies are available that clearly demonstrate the clinical benefit of 3D-printed materials. Nevertheless, 3D-printing technology continues to advance rapidly and promises to play an increasingly larger role in the field of urology. Herein, we review the current urological applications of 3D printing and discuss the potential impact of 3D-printing technology on the future of urological practice.

  15. Urology Tag Ontology Project: Standardizing Social Media Communication Descriptors.

    Science.gov (United States)

    Kutikov, Alexander; Woo, Henry H; Catto, James W

    2016-02-01

    Standardizing social media hashtag descriptors is likely to facilitate communication and promote collaboration in both health care provider and patient communities. Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  16. Image guided robotic surgery: Current evidence for effectiveness in urology

    Directory of Open Access Journals (Sweden)

    Anum Pervez

    2014-12-01

    Full Text Available Objectives: Discussion of the evolution of image guided surgery (IGS and its fundamental components and current evidence for effectiveness of IGS in clinical urology. Methods: Literature search for image-guided robotic urology. Results: Current literature in image-guided robotic urology with its use in robot assisted radical prostatectomy and robot assisted partial nephrectomy are shown. Conclusions: Image guided surgery can be a useful aid to improve visualisation of anatomy and subsurface structures during minimally invasive surgery. Soft-tissue deformation makes it difficult to implement IGS in urology but current studies have shown an attempt to address this issue. The feasibility of IGS requires randomised control trials assessing in particular its accuracy and affect on clinical outcome.

  17. A new era of Asian urology: a SWOT analysis.

    Science.gov (United States)

    Kumar, Rajeev

    2016-11-01

    Economic prosperity and increasing connectivity have made Asia an emerging centre of growth in health care, including in the field of urology. Large and varied patient populations, the availability of a trained workforce, the use of English as a common communication language, and overall low costs have contributed to this change. Rapid growth of regional urological associations and journals has fuelled the aspirations and abilities of Asian urologists to not only keep abreast of but often lead the change in urological disease management. Asian urology has immense potential to expand in areas in which it currently lags behind, the most important being research. The increasing ability to travel aids in developing networks for collaboration. However, Asian urologists will need to look at sustainable models of engagement and temper the need for short-term results if these opportunities are to reach their maximal potential.

  18. Optimizing urology group partnerships: collaboration strategies and compensation best practices.

    Science.gov (United States)

    Jacoby, Dana L; Maller, Bruce S; Peltier, Lisa R

    2014-10-01

    Market forces in health care have created substantial regulatory, legislative, and reimbursement changes that have had a significant impact on urology group practices. To maintain viability, many urology groups have merged into larger integrated entities. Although group operations vary considerably, the majority of groups have struggled with the development of a strong culture, effective decision-making, and consensus-building around shared resources, income, and expense. Creating a sustainable business model requires urology group leaders to allocate appropriate time and resources to address these issues in a proactive manner. This article outlines collaboration strategies for creating an effective culture, governance, and leadership, and provides practical suggestions for optimizing the performance of the urology group practice.

  19. Global map of lithosphere thermal thickness on a 1 deg x 1 deg grid - digitally available

    DEFF Research Database (Denmark)

    Artemieva, Irina

    2014-01-01

    than 250 km) lithosphere is restrictedsolely to young Archean terranes (3.0–2.6 Ga), while in old Archean cratons (3.6–3.0 Ga) lithospheric roots donot extend deeper than 200–220 km.The TC1 model is presented by a set of maps, which show significant thermal heterogeneity within continentalupper mantle......This presentation reports a 1 deg 1 deg global thermal model for the continental lithosphere (TC1). The modelis digitally available from the author’s web-site: www.lithosphere.info.Geotherms for continental terranes of different ages (early Archean to present) are constrained by reliabledata...... of the continents, the remaining areas (ca. 60% ofthe continents) are filled by the statistical numbers derived from the thermal model constrained by boreholedata. Continental geotherms are statistically analyzed as a function of age and are used to estimate lithospherictemperatures in continental regions...

  20. 'Image and treat': an individualized approach to urological tumors

    DEFF Research Database (Denmark)

    Bouchelouche, Kirsten; Capala, Jacek

    2010-01-01

    The current treatment options for advanced urologic cancers demonstrate limited efficacy. To obtain optimal clinical results, there is a need for new, individualized, therapeutic strategies, which have only recently been applied to these malignancies. Nuclear medicine plays an important role in e...... in establishing imaging biomarkers necessary for personalized medicine. This review focuses on the current status of the 'image and treat' approach combining molecular imaging with targeted radionuclide therapy of urological malignancies...

  1. The Global Prevalence of Infections in Urology Study

    DEFF Research Database (Denmark)

    Wagenlehner, Florian; Tandogdu, Zafer; Bartoletti, Riccardo;

    2016-01-01

    as urosepsis. The GPIU study has been annually performed since 2003. Eight-hundred fifty-six urology units from 70 countries have participated so far, including 27,542 patients. A proxy for antibiotic consumption is reflected by the application rates used for antibiotic prophylaxis for urological interventions....... Resistance rates of most uropathogens against antibiotics were high, especially with a note of multidrug resistance. The severity of HAUTI is also increasing, 25% being urosepsis in recent years....

  2. Study of 138 Neisseria meningitidis strains isolated from blood or cerebrospinal fluid in Lombardy between 2007 and 2010

    Directory of Open Access Journals (Sweden)

    Laura Daprai

    2012-06-01

    Full Text Available Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b cause the majority of cases of bacterial septicaemia in children and young adults. Disease epidemiology is evolving rapidly due to the introduction of vaccines and changing in bacterial antibiotic-resistance patterns. (Asymptomatic nasopharyngeal colonization with Neisseria meningitides occurs in 5-10% of adult. The aim of this study was to calculate the frequency of each serogroup of this pathogens involved in invasive infection and to study susceptibility to antibiotics of these strains. Between March 2007 and June 2010 we received, from 43 hospitals of Lombardy, 138 strains of Neisseria meningitidis, from 138 patients aged (2-80yrs. The most frequent serogroup was B (58%, followed by serogroup C (34%, serogroup G (4% and W 135 (2%. Serogroup A end X accounted for 1% of invasive infection, each. We observed a decrease in susceptibility towards penicillin in 38% of strains. In addition we studied, by REP- PCR, genotype of 9 strains selected on the basis of epidemiological data.Among these strains, 3 different clusters according to the 3 small epidemic outbreaks occurred between June and September 2009, were recognised. Seven of these strains, although belonged to the same serogroup, brought about two different clusters. The present findings demonstrated that phenotypic data are not sufficient to define epidemic clusters, therefore molecular genotyping is required.

  3. Home-Based Telemanagement in Advanced COPD: Who Uses it Most? Real-Life Study in Lombardy.

    Science.gov (United States)

    Vitacca, Michele; Fumagalli, Lia Paola; Borghi, Gabriella; Colombo, Fausto; Castelli, Alberto; Scalvini, Simonetta; Masella, Cristina

    2016-08-01

    Current evidence indicates that the benefits of tele-health may not be uniform across all patients. Therefore, to understand what specific variables influence use of home-based telemanagement in COPD, we conducted this retrospective study.  A 6-month home-based telemanagement program (HTP) was offered to 1,074 COPD patients over a 4-year period. Multivarible linear regression analysis was used to identify predictors of HTP use/week (phone calls and specialist consultations) among all variables: clinical (body mass index, co-morbidities, HTP prescription not following an exacerbation, long-term oxygen therapy use, COPD severity, hospital readmissions, exacerbations and death), socio-demographic (sex, age, place of abode), smoking history, arterial blood gases (ABG), and specialist/general practitioner (GP) urgent need. Logistic regression was conducted to predict relapses/hospitalizations risk as well as the disease impact (COPD Assessment Test, CAT) at the end of the program.  Presence of relapses (p HTP-use. Smoking history (OR 1.542 [IC 95% 1.069-2.217], p = 0.020), specialist (OR 2.895 [2.144-3.910], p HTP prescription (p HTP in Lombardy shows that relapsers, people requiring several ABGs and urgent GP visits are the patient subgroup most likely to consume telemanagement services (scheduled and unscheduled). We propose a patient 'identikit' to improve prioritization for HTP prescriptions.

  4. Location of quarries of magnesian lime used as raw material of Roman plasters in western Lombardy (Italy

    Directory of Open Access Journals (Sweden)

    Roberto Bugini

    2017-01-01

    Full Text Available Lime as building material was widely diffused in Roman architecture of western Lombardy. The presence of magnesite (magnesium carbonate was detected in painted plasters coming from roman sites of Milano: magnesite indicates the use of dolomite to make the lime. Dolomite rocks widely outcrop in the Lombard Prealps: light grey dolomites and dolomitic limestones (Dolomia del Salvatore, Ladinian-Anisian; grey dolomites, sometimes with cyclothemes (Dolomia Principale, Norian. There is no evidence of Roman lime quarries or kilns in this area; the Romans probably exploited the same dolomite outcrops, located along the eastern shore of lake Maggiore, where lime was produced from the Middle Ages onwards. The glacio-fluvial deposits of the middle course of the river Adda (cobbles, pebbles of siliceous limestone together with limestone and dolomite outcropping in the river basin were another medieval and modern source of raw material, mainly to make a moderately hydraulic lime (called “calce forte”, but this kind of lime is lacking in Roman plasters.

  5. Telmisartan inhibits human urological cancer cell growth through early apoptosis

    Science.gov (United States)

    MATSUYAMA, MASAHIDE; FUNAO, KIYOAKI; KURATSUKURI, KATSUYUKI; TANAKA, TOMOAKI; KAWAHITO, YUTAKA; SANO, HAJIME; CHARGUI, JAMEL; TOURAINE, JEAN-LOUIS; YOSHIMURA, NORIO; YOSHIMURA, RIKIO

    2010-01-01

    Angiotensin II receptor blockers (ARBs) are widely used as hypertensive therapeutic agents. In addition, studies have provided evidence that ARBs have the potential to inhibit the growth of several types of cancer cells. It was reported that telmisartan (a type of ARB) has peroxisome proliferator-activated receptor (PPAR)-γ activation activity. We previously reported that the PPAR-γ ligand induces growth arrest in human urological cancer cells through apoptosis. In this study, we evaluated the effects of telmisartan and other ARBs on cell proliferation in renal cell carcinoma (RCC), bladder cancer (BC), prostate cancer (PC) and testicular cancer (TC) cell lines. The inhibitory effects of telmisartan and other ARBs (candesartan, valsartan, irbesartan and losartan) on the growth of the RCC, BC, PC and TC cell lines was investigated using an MTT assay. Flow cytometry and Hoechst staining were used to determine whether the ARBs induced apoptosis. Telmisartan caused marked growth inhibition in the urological cancer cells in a dose- and time-dependent manner. Urological cancer cells treated with 100 μM telmisartan underwent early apoptosis and DNA fragmentation. However, the other ARBs had no effect on cell proliferation in any of the urological cancer cell lines. Telmisartan may mediate potent anti-proliferative effects in urological cancer cells through PPAR-γ. Thus, telmisartan is a potent target for the prevention and treatment of human urological cancer. PMID:22993542

  6. AB39. Cryotherapy in urologic neolplasms

    Science.gov (United States)

    He, Leye

    2014-01-01

    Cryosurgery has a long history dating back to the mid-1800s when James Arnott, an English physician, used a salt and ice mixture to treat cervical and breast carcinoma. Modern cryosurgery began in 1961 with the development of automated equipment by Cooper and Lee. Since then, tumors in various organs have been treated with cryoablation, and probes of various shapes and sizes have been designed to improve tumor accessibility and ablation. During the last decade there has been a resurgence of cryotherapy in the field of urology, particularly in the treatment of malignant lesions of the kidney and prostate. As a minimally invasive treatment, the cryotherapy appears to be the most durable. Currently, select kidney and prostatic lesions are treated using cryotherapy and clinical series have provided compelling results, promoting interest in renal and prostatic cryoablation. By the advancement of radiographic technology and surgical instrumentation, much of the interest has been promoted along with the movement toward to provide minimally invasive therapeutic options for patients. The optimal indication for renal cryotherapy is a peripheral, enhancing, well circumscribed lesion less than 4 cm. Along with tumor characteristics, certain patient populations may benefit from kidney cryotherapy. They include elderly patients with comorbidities, particularly hypertension, diabetes, kidney stones, renal insufficiency, cerebrovascular accidents, and congestive heart failure. Other considerations include unique situations such as lesions less than 4 cm in a solitary or transplant kidney, along with certain hereditary conditions such as von Hippel-Lindau disease, tuberous sclerosis, and hereditary papillary renal cell carcinoma. Contraindications to kidney cryoablation include locally advanced and/or metastatic disease and uncontrolled bleeding disorders. Other relative contraindications include lesions contiguous with bowel, great vessels, and/or tumor size of at least 5 cm

  7. OMP Peptides Activate the DegS Stress-Sensor Protease by a Relief of Inhibition Mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Jungsan; Grant, Robert A.; Sauer, Robert T.; MIT

    2010-03-19

    In the E. coli periplasm, C-terminal peptides of misfolded outer-membrane porins (OMPs) bind to the PDZ domains of the trimeric DegS protease, triggering cleavage of a transmembrane regulator and transcriptional activation of stress genes. We show that an active-site DegS mutation partially bypasses the requirement for peptide activation and acts synergistically with mutations that disrupt contacts between the protease and PDZ domains. Biochemical results support an allosteric model, in which these mutations, active-site modification, and peptide/substrate binding act in concert to stabilize proteolytically active DegS. Cocrystal structures of DegS in complex with different OMP peptides reveal activation of the protease domain with varied conformations of the PDZ domain and without specific contacts from the bound OMP peptide. Taken together, these results indicate that the binding of OMP peptides activates proteolysis principally by relieving inhibitory contacts between the PDZ domain and the protease domain of DegS.

  8. La poesia sabiana degli Anni Venti

    Directory of Open Access Journals (Sweden)

    Atilij Rakar

    1975-11-01

    Full Text Available Muovendo da un confronto fra il Saba del primo Canzoniere e le Figure e canti coi quali l'opera del poeta triestino continua negli anni venti, l'autore cerca di individuare i caratteri che meglio definiscono la poesia sabiana di questo secondo periodo. Messi in evidenza alcuni temi su cui verte il discorso sabiano fin delle Poesie dell'adolescenza e giovanili, le opere degli anni venti si rivelano come esiti di un poliforme compendio in cui il poeta vuol chiarire il senso del cammino percorso e comp:tendere quelle che sono le ragioni prime del suo poetare. Si manifestano qui, anche in maniera esplicita, alcuni motivi fondamentali del Canzionere: basti pensare, ad esempio, a Il borgo che offre la chiave per l'interprezazione di tutto un filone della tematica sabiana, o alle Fughe, con le quali il poeta vuol esprimere l'essenza del proprio sentire. La poetica delle »figure« e dei »canti« composti negli anni venti, non segnerebbe dunque una conversione di Saba ai »miti della forma«, come inducono a credere anche certe apostrofi del poeta stesso, rna può esser definita solo se vista in funzione dei contenuti che determinano il suo formarsi.

  9. Spin Interference in Rashba 2DEG Systems

    Science.gov (United States)

    Nitta, Junsaku

    The gate controllable SOI provides useful information about spin interference.1 Spin interference effects are studied in two different interference loop structures. It is known that sample specific conductance fluctuations affect the conductance in the interference loop. By using array of many interference loops, we carefully pick up TRS Altshuler-Aronov-Spivak (AAS)-type oscillation which is not sample specific and depends on the spin phase. The experimentally obtained gate voltage dependence of AAS oscillations indicates that the spin precession angle can be controlled by the gate voltage.2 We demonstrate the time reversal Aharonov-Casher (AC) effect in small arrays of mesoscopic rings.3 By using an electrostatic gate we can control the spin precession angle rate and follow the AC phase over several interference periods. We also see the second harmonic of the AC interference, oscillating with half the period. The spin interference is still visible after more than 20π precession angle. We have proposed a Stern-Gerlach type spin filter based on the Rashba SOI.4 A spatial gradient of effective magnetic field due to the nonuniform SOI separates spin up and down electrons. This spin filter works even without any external magnetic fields and ferromagnetic contacts. We show the semiconductor/ferromagnet hybrid structure is an effective way to detect magnetization process of submicron magnets. The problem of the spin injection from ferromagnetic contact into 2DEG is also disicussed. Note from Publisher: This article contains the abstract only.

  10. Evaluation of reconstruction arc in myocardial SPECT imaging using a cardiac phantom. Comparison between 360deg and 180deg arcs

    Energy Technology Data Exchange (ETDEWEB)

    Kashikura, Kenichi [Japan Science and Technology Corp., Tokyo (Japan); Kashikura, Akemi; Terada, Shinichirou; Kobayashi, Hideki

    1996-10-01

    In order to investigate the effect of reconstruction arc on myocardial SPECT images, a series of phantom studies was performed with and without plastic chambers simulating perfusion defects using {sup 201}Tl and {sup 99m}Tc. Coefficient of variations (CV) of the counts among the ROIs and defect contrast were evaluated in 360deg and 180deg images reconstructed from the same 360deg projection data. Reconstruction processes were identical for all images. In the absence of defects, the CV of the counts were approximately the same in 360deg and 180deg images. The CV of the counts in the 360deg {sup 201}Tl image, among 4 defects located on the anterior, lateral, inferoposterior, and septal walls, was superior to those in the 180deg images. In contrast, in the {sup 99m}Tc images, the CV of the counts among the 4 defects in the 180deg image was superior to those of the 360deg image. The defect contrast was changed both by the location of the defect and by the reconstruction arc ({sup 201}Tl, {sup 99m}Tc). The defect contrast of the 180deg images, in both {sup 201}Tl and {sup 99m}Tc experiments, was closer to the true contrast value as calculated by the count ratio between myocardium and defect. Although the defect contrast in the anterior, lateral and septal walls was more emphasized in the 180deg images, the defect contrast in the inferoposterior wall was less emphasized in the 180deg images compared to the 360deg ({sup 201}Tl, {sup 99m}Tc). (author)

  11. Urology on the internet - introduction and update

    Directory of Open Access Journals (Sweden)

    Inumpudi Anand

    2000-01-01

    Full Text Available The Internet, which has truly united the developed and developing nations, is an extensive network of inter-linked computers storing immense bytes of information, which can be accessed by anyone transcending all geographi-cal barriers and this has become the ultimate frontier to access information. The Urology and Andrology informa-tion on Internet is exponentially growing. The urologist need not know the intricacies of the hardware and soft-ware but can start right away navigating through this web. We reviewed methods available to take advantage of this network to provide a glimpse to busy urologists to accrue the benefits easily and efficiently rather than to be lost in the information-ocean by surfing individually. By getting connected to Internet, an urologist of any part of the world gains enormous information by interacting with other urologists of the rest of the world. This could be of use to gain knowledge and to offer the best and the most modern treatment to the patient. Internet has revolutionised the scientific publication by virtue of its faster and accurate transmission of manuscripts. We can send manuscripts by this channel and also access journals obviating the lag period inherent in snail mail. The on-line journals have virtually brought the library to the desktop.

  12. Lymphocele – urological complication after renal transplantation

    Directory of Open Access Journals (Sweden)

    Wojciech Krajewski

    2013-04-01

    Full Text Available Renal transplantation is the best renal replacement treatment. It provides longer survival and a better quality of life. The outcome of renal transplantation is influenced by the occurrence of various complications, including urological. One of the most frequently occurring complicationsis lymphocele. Most cases of lymphocele develop during a period of several weeks after the procedure of transplantation. However, there are some literature reports concerning lymphocele diagnosis in the later period, even after several years. Most cases of lymphocele are asymptomatic and are diagnosed accidentally. Nevertheless, a large lymphocele may press the kidney, ureter, urinary bladder or neighbouring blood vessels, causing deterioration of renal function, leg oedema and thrombosis of iliac vessels. Among other complications there are infections. The cause of lymphocele is collection of the lymph drained from damaged lymph vessels surrounding iliac blood vessels and/or lymph vessels of the graft. Important factors predisposing to lymphocele are immunosuppressive treatment, including mTOR inhibitors, mycophenolic acid derivatives and high doses of glucosteroids. Factors favouring occurrence of lymphocele comprise obesity, diabetes, elderly age of recipient, long time of warm ischaemia, acute rejection episodes and delayed graft function. The authors describe presently available treatment methods including aspiration and percutaneous drainage, with or without sclerotisation, drainage using the Tenckhoff catheter and laparoscopic or open fenestration. At present, laparoscopic fenestration is considered to be the most efficient and the safest method. However, there are clinical cases where open surgical treatment is necessary.

  13. Obesity and urologic complications after renal transplantation

    Directory of Open Access Journals (Sweden)

    Ashkan Heshmatzadeh Behzadi

    2014-01-01

    Full Text Available Although obesity has been associated with improved survival on dialysis, its short-and long-term effects on renal transplantation outcomes remain unclear. Herein, we evaluate the short-term and intermediate long-term effects of obesity on first-time renal transplant patients. A retrospective analysis was performed on 180 consecutive renal transplant recipients from living unrelated donors during 2006-2008 in a major transplantation center in Tehran, Iran. Among these, 34 (18% patients were found to be obese (body mass index ≥30 kg/m 2 . Obese patients were more likely to develop post-transplant renal artery stenosis (RAS (17.6% vs. 2.8%, P <0.001, hematoma (47.9% vs. 17.6, P = 0.009, surgical wound complications (64.7% vs. 9.6%, P <0.001 and renal vein thrombosis (2% vs. 0%, P <0.001. However, the incidence of delayed graft function, lymphocele, urologic complications of ureterovesical junction stenosis or urinary leakage, surgical complications of excessive bleeding or renal artery thrombosis and duration of hospitalization were similar between the two groups. The two-year patient and graft survival were also statistically not different. Renal transplantation in obese recipients is associated with a higher incidence of post-transplant RAS, hematoma, surgical wound complications and renal vein thrombosis, but similar two-year patient and graft survival.

  14. The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Wei [Chinese Academy of Sciences, 5 Datun Road, Chaoyang District, Beijing 100101 (China); University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049 (China); Gao, Feng [Chinese Academy of Sciences, 5 Datun Road, Chaoyang District, Beijing 100101 (China); Fan, Haitian; Shan, Xiaoyue [Chinese Academy of Sciences, 5 Datun Road, Chaoyang District, Beijing 100101 (China); University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049 (China); Sun, Renhua [Chinese Academy of Sciences, 20 Nanxincun, Haidian District, Beijing 100093 (China); University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049 (China); Liu, Lin, E-mail: liulin@ibcas.ac.cn [Chinese Academy of Sciences, 20 Nanxincun, Haidian District, Beijing 100093 (China); Gong, Weimin, E-mail: liulin@ibcas.ac.cn [Chinese Academy of Sciences, 5 Datun Road, Chaoyang District, Beijing 100101 (China)

    2013-05-01

    The crystal structures of Arabidopsis Deg5 and Deg8 have been determined to resolutions of 2.6 and 2.0 Å, respectively, revealing novel structural features of HtrA proteases. Plant Deg5 and Deg8 are two members of the HtrA proteases, a family of oligomeric serine endopeptidases that are involved in a variety of protein quality-control processes. These two HtrA proteases are located in the thylakoid lumen and participate in high-light stress responses by collaborating with other chloroplast proteins. Deg5 and Deg8 degrade photodamaged D1 protein of the photosystem II reaction centre, allowing its in situ replacement. Here, the crystal structures of Arabidopsis thaliana Deg5 (S266A) and Deg8 (S292A) are reported at 2.6 and 2.0 Å resolution, respectively. The Deg5 trimer contains two calcium ions in a central channel, suggesting a link between photodamage control and calcium ions in chloroplasts. Previous structures of HtrA proteases have indicated that their regulation usually requires C-terminal PDZ domain(s). Deg5 is unique in that it contains no PDZ domain and the trimeric structure of Deg5 (S266A) reveals a novel catalytic triad conformation. A similar triad conformation is observed in the hexameric structure of the single PDZ-domain-containing Deg8 (S292A). These findings suggest a novel activation mechanism for plant HtrA proteases and provide structural clues to their function in light-stress response.

  15. [Hygiene in Urological Surgeries - Results of the Health Authority's Visit to all Urological Surgeries in Braunschweig].

    Science.gov (United States)

    Buhr-Riehm, B; Lenz, T

    2015-07-01

    Following a patient complaint, the Health Department carried out a hygiene inspection of a urological practice in Braunschweig in February 2013. The topic of the complaint was that a patient assumed having acquired a resistant pathogen in the practice. In the subsequent visit, significant hygiene defects were found, particularly with regard to the processing of medical devices. This led to a decision to commit all urological practices in Braunschweig to hygiene inspections as part of a priority project. In retrospect, the hygiene surveys were justified. Deficiencies included inadequate preparation of medical products, procedures in practice inconsistent with hygiene plans, poor knowledge of hygiene procedures among assistant staff and doctors, lack of expertise of assistant staff and lack of hygiene risk awareness by doctors. Positive experiences were: open communication in a good atmosphere with the Practice managers, willingness to change, good cooperation between the Health Authority and the Labor Inspectorate and Physicians' Association. The claimed deficits were corrected by spring 2014 by the practice operators. The consulting expertise of the health authorities was made use of continuously. © Georg Thieme Verlag KG Stuttgart · New York.

  16. [The clinic Heilanstalt Weidenplan in Halle (Saale), origin of the German urology. Otto Kneise's founding of the first independent urology department in Germany].

    Science.gov (United States)

    Zacher, W; Stolze, K-J

    2014-07-01

    The routine use of cystoscope initiated the development of the modern urology. Otto Kneise (1875-1953) extended the targets of cystoscopy by including examinations of the male bladder and prostate. He achieved the goal that "cystoscopy is part of general work in urology and not a pure gynecological act". He, thus, founded the specialty gynecological urology in the field urology, which prevented it from becoming an independent field. Under the leadership of Otto Kneise, the first independent urology department in Germany was created in the hospital Heilanstalt Weidenplan.

  17. Neutron irradiation of silicon diodes at temperatures of +20deg C and -20deg C

    Energy Technology Data Exchange (ETDEWEB)

    Anghinolfi, F.; Glaser, M.; Heijne, E.H.M.; Jarron, P.; Lemeilleur, F.; Occelli, E.; Poppleton, A. (CERN, Geneva (Switzerland)); Bardos, R.; Gorfine, G.; Moorhead, G.; Taylor, G.; Tovey, S. (School of Physics, Univ. Melbourne, Parkville (Australia)); Bates, S.J.; Munday, D.J.; Parker, M.A. (Cavendish Lab., Univ. Cambridge (United Kingdom)); Bonino, R.; Clark, A.G.; Wu, X. (DPNC, Univ. Geneva (Switzerland)); Claussen, N.; Fretwurst, E.; Lindstroem, G.; Papendick, B.; Schulz, T.; Wunstorf, R. (Inst. fuer Experimentalphysik, Univ. Hamburg (Germany)); Goessling, C.; Klingenberg, R.; Pagel, H.; Pollmann, D.; Rolf, A. (Inst. fuer Physik, Univ. Dortmund (Germany)); Scampoli, P. (Dipt. di Fisica, Univ. Perugia (Italy) INFN, Sezione Perugia (Italy)); Weidberg, A.R. (Dept. of Nuclear Physics, Oxford Univ. (United Kingdom)); RD2 Collaboration

    1993-03-01

    We report measurements of the behaviour of silicon diodes when exposed to integrated neutron doses of up to 5x10[sup 13] neutrons/cm[sup 2]. The measurements have been made at diode temperatures between room temperature and -20deg C. From measurements of the diode leakage current and depletion voltage, and consequent evaluations of the effective impurity concentration, the temperature dependence of these quantities is discussed in terms of the annealing behaviour of the diodes. Comments are made on the suitability of silicon as a detector medium for particle physics experiments at future accelerators. (orig.).

  18. DegP Chaperone Suppresses Toxic Inner Membrane Translocation Intermediates

    Science.gov (United States)

    Braselmann, Esther; Chaney, Julie L.; Champion, Matthew M.

    2016-01-01

    The periplasm of Gram-negative bacteria includes a variety of molecular chaperones that shepherd the folding and targeting of secreted proteins. A central player of this quality control network is DegP, a protease also suggested to have a chaperone function. We serendipitously discovered that production of the Bordetella pertussis autotransporter virulence protein pertactin is lethal in Escherichia coli ΔdegP strains. We investigated specific contributions of DegP to secretion of pertactin as a model system to test the functions of DegP in vivo. The DegP chaperone activity was sufficient to restore growth during pertactin production. This chaperone dependency could be relieved by changing the pertactin signal sequence: an E. coli signal sequence leading to co-translational inner membrane (IM) translocation was sufficient to suppress lethality in the absence of DegP, whereas an E. coli post-translational signal sequence was sufficient to recapitulate the lethal phenotype. These results identify a novel connection between the DegP chaperone and the mechanism used to translocate a protein across the IM. Lethality coincided with loss of periplasmic proteins, soluble σE, and proteins regulated by this essential stress response. These results suggest post-translational IM translocation can lead to the formation of toxic periplasmic folding intermediates, which DegP can suppress. PMID:27626276

  19. DegP Chaperone Suppresses Toxic Inner Membrane Translocation Intermediates.

    Science.gov (United States)

    Braselmann, Esther; Chaney, Julie L; Champion, Matthew M; Clark, Patricia L

    2016-01-01

    The periplasm of Gram-negative bacteria includes a variety of molecular chaperones that shepherd the folding and targeting of secreted proteins. A central player of this quality control network is DegP, a protease also suggested to have a chaperone function. We serendipitously discovered that production of the Bordetella pertussis autotransporter virulence protein pertactin is lethal in Escherichia coli ΔdegP strains. We investigated specific contributions of DegP to secretion of pertactin as a model system to test the functions of DegP in vivo. The DegP chaperone activity was sufficient to restore growth during pertactin production. This chaperone dependency could be relieved by changing the pertactin signal sequence: an E. coli signal sequence leading to co-translational inner membrane (IM) translocation was sufficient to suppress lethality in the absence of DegP, whereas an E. coli post-translational signal sequence was sufficient to recapitulate the lethal phenotype. These results identify a novel connection between the DegP chaperone and the mechanism used to translocate a protein across the IM. Lethality coincided with loss of periplasmic proteins, soluble σE, and proteins regulated by this essential stress response. These results suggest post-translational IM translocation can lead to the formation of toxic periplasmic folding intermediates, which DegP can suppress.

  20. [Postoperative fever in orthopedic and urologic surgery].

    Science.gov (United States)

    Saavedra, Federico; Myburg, Cristina; Lanfranconi, Marisa B; Urtasun, Martin; De Oca, Luis Montes; Silberman, Andres; Lambierto, Alberto; Gnocchi, Cesar A

    2008-01-01

    Post-operative fever incidence varies widely. In clean and clean-contaminated surgery the non-infectious fever is more frequent than the infectious fever. We performed a prospective study including 303 patients who underwent orthopedic and urologic elective surgery. The aims of our study were to investigate the incidence of post-operative fever, its etiology, the relationship between time of onset and the etiology, and the usefulness of extensive fever work-up to determine post-operative infection. The incidence of post-operative fever was 14% (42/303) of which 81% (34/42) was noninfectious and 19% (8/42) was infectious. The etiology of the fever in the first 48 hours after surgery was always non-infectious (p fever work-up was performed in patients who presented fever only after the initial 48 hours of surgery with normal physical examination (n = 19) consisting of chest x-ray, blood (2) and urine cultures. The chest x-ray was normal in all the patients, the urine cultures were positive in four cases (21%, IC 95%: 6-45) and the blood cultures in only one case (5%, IC 95%: 0.1-26). Seven patients had post-operative infections without fever as a clinical sign. The most frequently observed etiology of post-operative fever was non-infectious, related to the normal inflammatory host response to surgery. Based on the present results, the extensive fever work-up performed to investigate post-operative infection does not seem to be a useful tool. The diagnosis of post-operative infection was based on clinical follow up and the correct interpretation of the patient's symptoms and signs.

  1. Urologic surgery laparoscopic access: vascular complications

    Science.gov (United States)

    Branco, Anibal Wood

    2017-01-01

    ABSTRACT Vascular injury in accidental punctures may occur in large abdominal vessels, it is known that 76% of injuries occur during the development of pneumoperitoneum. The aim of this video is to demonstrate two cases of vascular injury occurring during access in laparoscopic urologic surgery. The first case presents a 60-year old female patient with a 3cm tumor in the superior pole of the right kidney who underwent a laparoscopic partial nephrectomy. After the Verres needle insertion, output of blood was verified. During the evaluation of the cavity, a significant hematoma in the inferior vena cava was noticed. After the dissection, a lesion in the inferior vena cava was identified and controlled with a prolene suture, the estimated bloos loss was 300ml. The second case presents a 42-year old female live donor patient who had her right kidney selected to laparoscopic live donor nephrectomy. After the insertion of the first trocar, during the introduction of the 10mm scope, an active bleeding from the mesentery was noticed. The right colon was dissected and an inferior vena cava perforation was identified; a prolene suture was used to control the bleeding, the estimated blood loss was 200mL, in both cases the patients had no previous abdominal surgery. Urologists must be aware of this uncommon, serious, and potentially lethal complication. Once recognized and in the hands of experienced surgeons, some lesions may be repaired laparoscopically. Whenever in doubt, the best alternative is the immediate conversion to open surgery to minimize morbidity and mortality. PMID:28124541

  2. Implications of Biofilm Formation on Urological Devices

    Science.gov (United States)

    Cadieux, Peter A.; Wignall, Geoffrey R.; Carriveau, Rupp; Denstedt, John D.

    2008-09-01

    Despite millions of dollars and several decades of research targeted at their prevention and eradication, biofilm-associated infections remain the major cause of urological device failure. Numerous strategies have been aimed at improving device design, biomaterial composition, surface properties and drug delivery, but have been largely circumvented by microbes and their plethora of attachment, host evasion, antimicrobial resistance, and dissemination strategies. This is not entirely surprising since natural biofilm formation has been going on for millions of years and remains a major part of microorganism survival and evolution. Thus, the fact that biofilms develop on and in the biomaterials and tissues of humans is really an extension of this natural tendency and greatly explains why they are so difficult for us to combat. Firstly, biofilm structure and composition inherently provide a protective environment for microorganisms, shielding them from the shear stress of urine flow, immune cell attack and some antimicrobials. Secondly, many biofilm organisms enter a metabolically dormant state that renders them tolerant to those antibiotics and host factors able to penetrate the biofilm matrix. Lastly, the majority of organisms that cause biofilm-associated urinary tract infections originate from our own oral cavity, skin, gastrointestinal and urogenital tracts and therefore have already adapted to many of our host defenses. Ultimately, while biofilms continue to hold an advantage with respect to recurrent infections and biomaterial usage within the urinary tract, significant progress has been made in understanding these dynamic microbial communities and novel approaches offer promise for their prevention and eradication. These include novel device designs, antimicrobials, anti-adhesive coatings, biodegradable polymers and biofilm-disrupting compounds and therapies.

  3. Sensing Slow Mobility and Interesting Locations for Lombardy Region (italy): a Case Study Using Pointwise Geolocated Open Data

    Science.gov (United States)

    Brovelli, M. A.; Oxoli, D.; Zurbarán, M. A.

    2016-06-01

    During the past years Web 2.0 technologies have caused the emergence of platforms where users can share data related to their activities which in some cases are then publicly released with open licenses. Popular categories for this include community platforms where users can upload GPS tracks collected during slow travel activities (e.g. hiking, biking and horse riding) and platforms where users share their geolocated photos. However, due to the high heterogeneity of the information available on the Web, the sole use of these user-generated contents makes it an ambitious challenge to understand slow mobility flows as well as to detect the most visited locations in a region. Exploiting the available data on community sharing websites allows to collect near real-time open data streams and enables rigorous spatial-temporal analysis. This work presents an approach for collecting, unifying and analysing pointwise geolocated open data available from different sources with the aim of identifying the main locations and destinations of slow mobility activities. For this purpose, we collected pointwise open data from the Wikiloc platform, Twitter, Flickr and Foursquare. The analysis was confined to the data uploaded in Lombardy Region (Northern Italy) - corresponding to millions of pointwise data. Collected data was processed through the use of Free and Open Source Software (FOSS) in order to organize them into a suitable database. This allowed to run statistical analyses on data distribution in both time and space by enabling the detection of users' slow mobility preferences as well as places of interest at a regional scale.

  4. [Complexity of care and organizational effectiveness: a survey among medical care units in nine Lombardy region hospitals].

    Science.gov (United States)

    Pasquali, Sara; Capitoni, Enrica; Tiraboschi, Giuseppina; Alborghetti, Adriana; De Luca, Giuseppe; Di Mauro, Stefania

    2017-01-01

    Eleven medical care units of nine Lombardy Region hospitals organized by levels of care model or by the traditional departmental model have been analyzed, in order to evaluate if methods for complexity of patient-care evaluation represent an index factor of nursing organizational effectiveness. Survey with nine Nurses in managerial position was conducted between Nov. 2013-Jan. 2014. The following factors have been described: context and nursing care model, staffing, complexity evaluation, patient satisfaction, staff well-being. Data were processed through Microsoft Excel. Among Units analysed ,all Units in levels of care and one organized by the departmental model systematically evaluate nursing complexity. Registered Nurses (RN) and Health Care Assistants (HCA) are on average numerically higher in Units that measure complexity (0.55/ 0.49 RN, 0.38/0.23 HCA - ratio per bed). Adopted measures in relation to changes in complexity are:rewarding systems, supporting interventions, such as moving personnel within different Units or additional required working hours; reduction in number of beds is adopted when no other solution is available. Patient satisfaction is evaluated through Customer Satisfaction questionnaires. Turnover, stress and rate of absenteeism data are not available in all Units. Complexity evaluation through appropriate methods is carried out in all hospitals organized in levels of care with personalized nursing care models, though complexity is detected with different methods. No significant differences in applied managerial strategies are present. Patient's satisfaction is evaluated everywhere. Data on staffing wellbeing is scarcely available. Coordinated regional actions are recommended in order to gather comparable data for research, improve decision making and effectiveness of Nursing care.

  5. EVIDENCE OF A "MID-CARNIAN" TRANSGRESSION IN THE WESTERN SOUTHERN ALPS (LOMBARDY, ITALY: STRATIGRAPHIC AND PALEOGEOGRAPHIC IMPLICATIONS

    Directory of Open Access Journals (Sweden)

    FABRIZIO BERRA

    2002-03-01

    Full Text Available A "mid-Carnian" transgressive succession, developed between the Breno carbonate platform and the semiarid coastal carbonates-sabkhas facies of the S. Giovanni Bianco Fm., is recorded in the northern Bergamasc Alps. This episode is characterized by the presence of two stratigraphic markers:  a Dark grey shales and siltstones ("Black Pelites", considered previously as the northern closure of the Gorno-Lower S. Giovanni Bianco Fms., but re-interpreted as the western pinch-out of the Lozio Shale depositional system. The Early Carnian Lozio Shale was deposited first in the Valle di Scalve-Lozio trough and later covered the carbonate platform (Breno Fm..b Fossiliferous, open subtidal limestones, marls and burrowed marly limestones ("Bioclastic Horizon" of the northern Bergamasc Alps. The spreading of shales and siltstones represents the first transgressive stage of the last Carnian sequence in Lombardy, after the "mid- Carnian" (Julian substage regional carbonate platform crisis (top of the Valcamonica Breno Fm.. The "Bioclastic Horizon" records the mfs represented by normal, open marine facies, identified and correlated throughout the Bergamasc Alps. Different petrographic and chemical characters between the Lozio Shale - "Black Pelites" and the Gorno-San Giovanni Bianco Fms. suggest different source areas: the former units are characterized by clasts derived from a metamorphic-intrusive area (placed northward and westward, whereas the latter units are characterized by prevailing volcaniclastic material. A climatic change (from arid to relatively humid conditions may be invoked to explain the crisis of the "mid-Carnian" carbonate platforms in the western Southern Alps and the regional spreading of fine-grained terrigenous material. 

  6. The standardization of results on hair testing for drugs of abuse: An interlaboratory exercise in Lombardy Region, Italy.

    Science.gov (United States)

    Stramesi, C; Vignali, C; Groppi, A; Caligara, M; Lodi, F; Pichini, S; Jurado, C

    2012-05-10

    Hair testing for drugs of abuse is performed in Lombardy by eleven analytical laboratories accredited for forensic purposes, the most frequent purposes being driving license regranting and workplace drug testing. Individuals undergoing hair testing for these purposes can choose the laboratory in which the analyses have to be carried out. The aim of our study was to perform an interlaboratory exercise in order to verify the level of standardization of hair testing for drugs of abuse in these accredited laboratories; nine out of the eleven laboratories participated in this exercise. Sixteen hair strands coming from different subjects were longitudinally divided in 3-4 aliquots and distributed to participating laboratories, which were requested to apply their routine methods. All the participants analyzed opiates (morphine and 6-acetylmorphine) and cocainics (cocaine and benzoylecgonine) while only six analyzed methadone and amphetamines (amphetamine, methamphetamine, MDMA, MDA and MDEA) and five Δ(9)-tetrahydrocannabinol (THC). The majority of the participants (seven labs) performed acidic hydrolysis to extract the drugs from the hair and analysis by GC-MS, while two labs used LC-MS/MS. Eight laboratories performed initial screening tests by Enzyme Multiplied Immunoassay Technique (EMIT), Enzyme-linked Immunosorbent Assay (ELISA) or Cloned Enzyme Donor Immunoassay (CEDIA). Results demonstrated a good qualitative performance for all the participants, since no false positive results were reported by any of them. Quantitative data were quite scattered, but less in samples with low concentrations of analytes than in those with higher concentrations. Results from this first regional interlaboratory exercise show that, on the one hand, individuals undergoing hair testing would have obtained the same qualitative results in any of the nine laboratories. On the other hand, the scatter in quantitative results could cause some inequalities if any interpretation of the data is

  7. Involvement of DEG5 and DEG8 proteases in the turnover of the photosystem II reaction center D1 protein under heat stress in Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    SUN XuWu; WANG LiYuan; ZHANG LiXin

    2007-01-01

    Deg5,deg8 and the double mutant,deg5deg8 of Arabidopsis thaliana were used to study the physiological role of the DEG proteases in the repair cycle of photosystem II (PSII) under heat stress. PSII activity in deg mutants showed increased sensitivity to heat stress,and the extent of this effect was greater in the double mutant,deg5deg8,than in the single mutants,deg5 and deg8. Degradation of the D1 protein was slower in the mutants than in the WT plants. Furthermore,the levels of other PSII reaction center proteins tested remained relatively stable in the mutant and WT plants following high-temperature treatment. Thus,our results indicate that DEG5 and DEG8 may have synergistic function in degradation of D1 protein under heat stress.

  8. The Prevalence of the 22 deg Halo in Cirrus Clouds

    Science.gov (United States)

    Diedenhoven, vanBastiaan

    2014-01-01

    Halos at 22 deg from the sun attributed to randomly-orientated, pristine hexagonal crystals are frequently observed through ice clouds. These frequent sightings of halos formed by pristine crystals pose an apparent inconsistency with the dominance of distorted, nonpristine ice crystals indicated by in situ and remote sensing data. Furthermore, the 46 deg halo, which is associated with pristine hexagonal crystals as well, is observed far less frequently than the 22 deg halo. Considering that plausible mechanisms that could cause crystal distortion such as aggregation, sublimation, riming and collisions are stochastic processes that likely lead to distributions of crystals with varying distortion levels, here the presence of the 22 deg and 46 deg halo features in phase functions of mixtures of pristine and distorted hexagonal ice crystals is examined. We conclude that the 22 deg halo feature is generally present if the contribution by pristine crystals to the total scattering cross section is greater than only about 10% in the case of compact particles or columns, and greater than about 40% for plates. The 46 deg halo feature is present only if the mean distortion level is low and the contribution of pristine crystals to the total scattering cross section is above about 20%, 50% and 70%, in the case of compact crystals, plates and columns, respectively. These results indicate that frequent sightings of 22 deg halos are not inconsistent with the observed dominance of distorted, non-pristine ice crystals. Furthermore, the low mean distortion levels and large contributions by pristine crystals needed to produce the 461 halo features provide a potential explanation of the common sighting of the 22 deg halo without any detectable 46 deg halo.

  9. Readability assessment of online urology patient education materials.

    Science.gov (United States)

    Colaco, Marc; Svider, Peter F; Agarwal, Nitin; Eloy, Jean Anderson; Jackson, Imani M

    2013-03-01

    The National Institutes of Health, American Medical Association, and United States Department of Health and Human Services recommend that patient education materials be written at a fourth to sixth grade reading level to facilitate comprehension. We examined and compared the readability and difficulty of online patient education materials from the American Urological Association and academic urology departments in the Northeastern United States. We assessed the online patient education materials for difficulty level with 10 commonly used readability assessment tools, including the Flesch Reading Ease Score, Flesch-Kincaid Grade Level, Simple Measure of Gobbledygook, Gunning Frequency of Gobbledygook, New Dale-Chall Test, Coleman-Liau index, New Fog Count, Raygor Readability Estimate, FORCAST test and Fry score. Most patient education materials on the websites of these programs were written at or above the eleventh grade reading level. Urological online patient education materials are written above the recommended reading level. They may need to be simplified to facilitate better patient understanding of urological topics. Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  10. Application of artificial intelligence to the management of urological cancer.

    Science.gov (United States)

    Abbod, Maysam F; Catto, James W F; Linkens, Derek A; Hamdy, Freddie C

    2007-10-01

    Artificial intelligence techniques, such as artificial neural networks, Bayesian belief networks and neuro-fuzzy modeling systems, are complex mathematical models based on the human neuronal structure and thinking. Such tools are capable of generating data driven models of biological systems without making assumptions based on statistical distributions. A large amount of study has been reported of the use of artificial intelligence in urology. We reviewed the basic concepts behind artificial intelligence techniques and explored the applications of this new dynamic technology in various aspects of urological cancer management. A detailed and systematic review of the literature was performed using the MEDLINE and Inspec databases to discover reports using artificial intelligence in urological cancer. The characteristics of machine learning and their implementation were described and reports of artificial intelligence use in urological cancer were reviewed. While most researchers in this field were found to focus on artificial neural networks to improve the diagnosis, staging and prognostic prediction of urological cancers, some groups are exploring other techniques, such as expert systems and neuro-fuzzy modeling systems. Compared to traditional regression statistics artificial intelligence methods appear to be accurate and more explorative for analyzing large data cohorts. Furthermore, they allow individualized prediction of disease behavior. Each artificial intelligence method has characteristics that make it suitable for different tasks. The lack of transparency of artificial neural networks hinders global scientific community acceptance of this method but this can be overcome by neuro-fuzzy modeling systems.

  11. Robotics in urological surgery: evolution, current status and future perspectives.

    Science.gov (United States)

    Sivaraman, A; Sanchez-Salas, R; Prapotnich, D; Barret, E; Mombet, A; Cathala, N; Rozet, F; Galiano, M; Cathelineau, X

    2015-09-01

    Robotic surgery is rapidly evolving and has become an essential part of surgical practice in several parts of the world. Robotic technology will expand globally and most of the surgeons around the world will have access to surgical robots in the future. It is essential that we are updated about the outcomes of robot assisted surgeries which will allow everyone to develop an unbiased opinion on the clinical utility of this innovation. In this review we aim to present the evolution, objective evaluation of clinical outcomes and future perspectives of robot assisted urologic surgeries. A systematic literature review of clinical outcomes of robotic urological surgeries was made in the PUBMED. Randomized control trials, cohort studies and review articles were included. Moreover, a detailed search in the web based search engine was made to acquire information on evolution and evolving technologies in robotics. The present evidence suggests that the clinical outcomes of the robot assisted urologic surgeries are comparable to the conventional open surgical and laparoscopic results and are associated with fewer complications. However, long term results are not available for all the common robotic urologic surgeries. There are plenty of novel developments in robotics to be available for clinical use in the future. Robotic urologic surgery will continue to evolve in the future. We should continue to critically analyze whether the advances in technology and the higher cost eventually translates to improved overall surgical performance and outcomes. Copyright © 2014 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  12. Antibiotic prophylaxis for transurethral urological surgeries: Systematic review.

    Science.gov (United States)

    Alsaywid, Basim S; Smith, Grahame H H

    2013-04-01

    The use of antibiotic prophylaxis to prevent urinary tract infection and bacteremia (sepsis) following endoscopic urologic procedures is a controversial topic. Evidence in the literature revealed that urological instrumentation is associated with increased incidence of urinary tract infection and bacteremia. The aim of this review is to evaluate the effectiveness of antibiotic prophylaxis in reducing the risk of urinary tract infection in patients who had transurethral urological surgeries. We have selected all RCTs of adult population who underwent all different types of transurethral urological surgery, including cystoscopy, transurethral resection of prostate and transurethral resection of bladder tumor, and received prophylactic antibiotics or placebo/no treatment. At first, more than 3000 references were identified and reviewed; of which 42 studies with a total of 7496 patients were included in the final analysis. All those trials were analyzing antibiotic prophylaxis versus placebo/no treatment, and they were significantly favoring antibiotic use in reducing all outcomes, including bacteriuria (RR 0.36, 95% CI 0.29 to 0.46, P urinary tract infections and its sequels following transurethral urological surgeries in patients with preoperative sterile urine.

  13. Recent trends in the urology workforce in the United States.

    Science.gov (United States)

    Pruthi, Raj S; Neuwahl, Simon; Nielsen, Matthew E; Fraher, Erin

    2013-11-01

    The present study examines the current status of urology physician manpower in the United States, in the context of trends in the demographics, geographic distribution, and practice make-up of urologists. Physicians were identified as surgeons and classified into surgical groups using a combination of American Medical Association primary and secondary self-reported specialties and American Board of Medical Specialties certifications. From these groups, urologic surgeons were isolated for analysis. The supply of urologists per capita has declined since 1981 - most dramatically since 1991. With an average age of 52.5 years, urology is one of the oldest surgical specialties. Over 7% of urologists are older than 70 years and 44% are older than 55 years, suggesting an aging urology workforce. The number of female urologists has grown almost a 1000-fold and represents a growing and younger cohort of the workforce. The number of rural urologists and the number of international medical graduates have continued to decline since 1981. Over the past 10 years, an increasing number of urologists are now in group practices (over 60%), and these tended to be younger and in urban settings. In contrast to most other surgical specialties, there has been a decrease in the supply of urologists relative to population growth, which is expected to be exacerbated by an aging and relatively older urology physician workforce, particularly in rural areas, a slight increase in female urologists, and the gravitation of younger urologists toward group practice in urban areas.

  14. 2015-2018 Regional Prevention Plan of Lombardy (Northern Italy) and sedentary prevention: a cross-sectional strategy to develop evidence-based programmes.

    Science.gov (United States)

    Coppola, Liliana; Ripamonti, Ennio; Cereda, Danilo; Gelmi, Giusi; Pirrone, Lucia; Rebecchi, Andrea

    2016-01-01

    Cross-sector, life-course, and setting approaches are identified in the 2015-2018 Regional Prevention Plan (PRP) of Lombardy Region (Northern Italy) as valuable strategies to ensure the efficacy and sustainable prevention of the non-communicable disease (NCDs). The involvement of non-health sectors in health promotion activities represents a suitable strategy to affect on social, economic, and political determinants and to change environmental factors that could cause NCDs. A dialogue among communities, urban planning, and prevention know-how is a prerequisite to develop a system of policies suitable to promote healthy lifestyle in general and, specifically, active lifestyles. The 2015-2018 Lombardy PRP pursues its aims of health promotion and behavioural risk factors for NCDs prevention through programmes that implement their own setting networks (Health Promoting Schools - SPS; Workplace Health Promotion - WHP) and develop new networks. Sedentary lifestyle prevention and active lifestyle promotion are performed through the approach promoted by the Healthy Cities Programme (WHO), encouraging two main processes: 1. creating integrated capacity-building among health and social prevention services, academic research, and local stakeholders on different urban planning and design issues; 2. promoting community empowerment through active citizens participation. Through this process, Lombardy Region aims to orient its services developing evidence-based programmes and enhancing advocacy and mediating capacity skills in order to create a profitable partnership with non-health sectors. This paper reports the main impact data: 26,000 children that reach school by foot thanks to walking buses, 57% of 145 companies joining WHP are involved in promoting physical activity, 18,891 citizens who attend local walking groups.

  15. La formazione iniziale degli insegnanti in Italia

    Directory of Open Access Journals (Sweden)

    Carlo Cappa

    2013-07-01

    Full Text Available L’articolo è diviso in tre parti. La prima presenta gli elementi storici e di sfondo che occorre tenere presenti per comprendere l’evoluzione della formazione iniziale degli insegnanti verso gli attuali modelli, che pur essendo oggi tutti gestiti dalle università conservano una sensibile diversità a seconda che si tratti di formare maestri per la scuola dell’infanzia e primaria oppure professori di scuola secondaria di primo e secondo grado. La seconda parte analizza il passaggio, maturato tra la fine del secolo scorso e l’inizio del XXI secolo, della formazione dei maestri dalla scuola secondaria (Istituto magistrale all’università (Corso di laurea in Scienze della formazione primaria, e l’istituzione delle Scuole di Specializzazione per l’Insegnamento Secondario (SSIS fino alla soppressione di queste ultime, avvenuta nel 2009. La terza parte presenta il quadro attuale della formazione iniziale dei docenti in Italia con riguardo soprattutto agli insegnanti della scuola secondaria, per i quali – a differenza che per i maestri - sono intervenute dal 2010 importanti innovazioni legislative. Le SSIS sono state infatti sostituite con il Tirocinio Formativo Attivo (TFA, attualmente in fase di attuazione da parte delle università. Nella parte finale dell’articolo si traccia un primo bilancio dell’esperienza del TFA e si indicano alcuni problemi aperti. Il focus rimane sostanzialmente sulla formazione iniziale, in quanto in Italia la formazione in servizio, che pure non è del tutto assente, non è mai stata oggetto di una normativa né di una azione organica, ma avviene, quando avviene, sulla base di iniziative di specifici gruppi o associazioni.The article is organised in three parts. The first one illustrates the historical features and the institutional and political background that have to be taken into account in order to understand how initial teacher education and training has developed in Italy. Presently, all teacher

  16. The role of human papilloma virus in urological malignancies.

    Science.gov (United States)

    Heidegger, Isabel; Borena, Wegene; Pichler, Renate

    2015-05-01

    Human papillomavirus (HPV) is associated with cancer of the cervix uteri, penis, vulva, vagina, anus and oropharynx. However, the role of HPV infection in urological tumors is not yet clarified. HPV appears not to play a major causative role in renal and testicular carcinogenesis. However, HPV infection should be kept in mind regarding cases of prostate cancer, as well as in a sub-group of patients with bladder cancer with squamous differentiation. Concerning the role of HPV in penile cancer incidence, it is a recognized risk factor proven in a large number of studies. This short review provides an update regarding recent literature on HPV in urological malignancies, thereby, also discussing possible limitations on HPV detection in urological cancer.

  17. The emerging role of social media in urology.

    Science.gov (United States)

    Leveridge, Michael J

    2014-01-01

    Social media have become so integrated into modern communications as to be universal in our personal and, increasingly, professional lives. Recent examples of social media uptake in urology, and the emergence of data to quantify it, reveal the expansion of conventional communication routes beyond the in-person forum. In every domain of urologic practice, from patient interaction through research to continuing professional development, the move online has unlocked another layer of conversation, dissemination, and, indeed, caveats. Social media have a democratizing effect, placing patients, trainees, practitioners, and thought leaders in the same arena and on equal footing. If uptake of social media in medicine even remotely parallels its rise to ubiquity in other areas, it will only expand and evolve in the coming years. For these reasons, this article presents an overview of the most recent data on the impact and potential complications of social media usage in the urologic community.

  18. Urological conditions in pregnancy: a diagnostic and therapeutic challenge.

    Science.gov (United States)

    Shrotri, K N; Morrison, I D; Shrotri, N C

    2007-10-01

    Urological conditions in pregnancy represent a major diagnostic and therapeutic challenge. The potential adverse effects of anaesthesia, radiation and drugs on the fetus often complicate traditional diagnostic and treatment measures. As frontline clinicians, obstetricians need an awareness of symptoms, associated obstetric complications and an appreciation of available current diagnostic and therapeutic modalities and their associated risks. This article describes common urinary problems encountered in pregnancy: infection, hydronephrosis and urolithiasis specifically. The aim of this paper is to review the safety, efficacy and role of different imaging studies available for the diagnosis of urolithiasis in pregnancy. Conservative management as first line treatment and a variety of interventional urological procedures with postoperative management are also discussed. Such a background may facilitate a rational management protocol for urological problems in a pregnant woman.

  19. Image-guided urological interventions: What the urologists must know

    Directory of Open Access Journals (Sweden)

    Chandan J Das

    2015-01-01

    Full Text Available Advances in imaging technology, especially in the last two decades, have led to a paradigm shift in the field of image-guided interventions in urology. While the traditional biopsy and drainage techniques are firmly established, image-based stone management and endovascular management of hematuria have evolved further. Ablative techniques for renal and prostate cancer and prostate artery embolization for benign prostatic hypertrophy have evolved into viable alternative treatments. Many urologic diseases that were earlier treated surgically are now effectively managed using minimally invasive image-guided techniques, often on a day care basis using only local anesthesia or conscious sedation. This article presents an overview of the technique and status of various image-guided urological procedures, including recent emerging techniques.

  20. Coalition for the advancement of prosthetic urology: history, accomplishments, and continuing mission.

    Science.gov (United States)

    Daubert, Gail

    2006-11-01

    The Coalition for the Advancement of Prosthetic Urology (CAPU) is the leading policy advocacy group representing the prosthetic urology community and has been very effective in educating federal health care policy-makers.

  1. Late urologic morbidity in 177 consecutive patients after radiotherapy for cervical carcinoma: a longitudinal study

    DEFF Research Database (Denmark)

    Lajer, Henrik; Thranow, Ingrid R.; Skovgaard, Lene Theil;

    2002-01-01

    Radiotherapy; carcinoma of the uterine cervix; Urologic morbidity; Franco-Italian glossary; Actuarial estimate......Radiotherapy; carcinoma of the uterine cervix; Urologic morbidity; Franco-Italian glossary; Actuarial estimate...

  2. Identification of Underserved Areas for Urologic Cancer Care

    Science.gov (United States)

    Mossanen, Matthew; Izard, Jason; Wright, Jonathan L.; Harper, Jonathan D.; Porter, Michael P.; Daratha, Kenn B.; Holt, Sarah K.; Gore, John L.

    2014-01-01

    BACKGROUND The delivery of urologic oncology care is susceptible to regional variation. In the current study, the authors sought to define patterns of care for patients undergoing genitourinary cancer surgery to identify underserved areas for urologic cancer care in Washington State. METHODS The authors accessed the Washington State Comprehensive Hospital Abstract Reporting System from 2003 through 2007. They identified patients undergoing radical prostatectomy, radical cystectomy (RC), partial nephrectomy (PN), radical nephrectomy, and transurethral resection of the prostate (TURP). TURP was included for comparison as a reference procedure indicative of access to urologic care. Hospital service areas (HSAs) are where the majority of local patients are hospitalized; hospital referral regions (HRR) are where most patients receive tertiary care. The authors created multivariate hierarchical logistic regression models to examine patient and HSA characteristics associated with the receipt of urologic oncology care out of the HRR for each procedure RESULTS Greater than one-half of patients went out of their HRR in 7 HSAs (11%) for radical prostatectomy, 3 HSAs (5%) for radical nephrectomy, 10 HSAs (15%) for PN, and 14 HSAs (22%) for RC. No HSAs had high export rates for TURP. Few patient factors were found to be associated with surgical care out of the HRR. High-export HSAs for PN and RC exhibited lower socioeconomic characteristics than low-export HSAs, adjusting for HSA population, race, and HSA procedure rates for PN and RC. CONCLUSIONS Patients living in areas with lower socioeconomic status have a greater need to travel for complex urologic surgery. Consideration of geographic delineation in the delivery of urologic oncology care may aid in regional quality improvement initiatives. PMID:24523042

  3. Future of robotic surgery in urology.

    Science.gov (United States)

    Rassweiler, Jens J; Autorino, Riccardo; Klein, Jan; Mottrie, Alex; Goezen, Ali Serdar; Stolzenburg, Jens-Uwe; Rha, Koon H; Schurr, Marc; Kaouk, Jihad; Patel, Vipul; Dasgupta, Prokar; Liatsikos, Evangelos

    2017-03-20

    To provide a comprehensive overview of the current status of the field of robotic systems for urological surgery and discuss future perspectives. A non-systematic literature review was performed using PubMed/Medline search electronic engines. Existing patents for robotic devices were researched using the Google search engine. Findings were also critically analysed taking into account the personal experience of the authors. The relevant patents for the first generation of the da Vinci platform will expire in 2019. New robotic systems are coming onto the stage. These can be classified according to type of console, arrangement of robotic arms, handles and instruments, and other specific features (haptic feedback, eye-tracking). The Telelap ALF-X robot uses an open console with eye-tracking, laparoscopy-like handles with haptic feedback, and arms mounted on separate carts; first clinical trials with this system were reported in 2016. The Medtronic robot provides an open console using three-dimensional high-definition video technology and three arms. The Avatera robot features a closed console with microscope-like oculars, four arms arranged on one cart, and 5-mm instruments with six degrees of freedom. The REVO-I consists of an open console and a four-arm arrangement on one cart; the first experiments with this system were published in 2016. Medicaroid uses a semi-open console and three robot arms attached to the operating table. Clinical trials of the SP 1098-platform using the da Vinci Xi for console-based single-port surgery were reported in 2015. The SPORT robot has been tested in animal experiments for single-port surgery. The SurgiBot represents a bedside solution for single-port surgery providing flexible tube-guided instruments. The Avicenna Roboflex has been developed for robotic flexible ureteroscopy, with promising early clinical results. Several console-based robots for laparoscopic multi- and single-port surgery are expected to come to market within the

  4. Ketamine cystitis: Its urological impact and management

    Directory of Open Access Journals (Sweden)

    Yao Chou Tsai

    2015-09-01

    Full Text Available Ketamine, an n-methyl-d-aspartic acid receptor complex antagonist, has been used as an anesthetic and/or analgesic. However, in the past decade, ketamine has been illegally available as a recreational drug in Asian countries and Taiwan. Due to the characteristic of being short-acting, youngsters widely assume that ketamine is not as harmful as other drugs, such as heroin. Consequently, many young patients used this drug for a longer duration before they presented with severe urinary frequency and urgency symptoms. Subsequently, other cases have been reported in Taiwan, Hong Kong, Singapore, Malaysia, and Europe. Ketamine abuse is increasing, with rates of 0.30% in 2006 to 0.40% in 2007 among those in the 16–59 year age group. In general, affected patients tend to be young with a peak age range of 16–35 years. The incidence of lower urinary tract symptoms in ketamine abuse patients is around 30%. The actual underlying pathomechanism of ketamine cystitis (KC and associated pelvic pain remains unclear. It is speculated that chronic contact and stimulation to the bladder or ureteral mucosa due to metabolites of ketamine will result in submucosal edema, vascular ectasia, fibrosis, detrusor muscle inflammation, and fibrosis. Presentations of KC include remarkable dysuria, urinary frequency/urgency, urge incontinence, and bladder pain. Urine culture usually fails to yield any microbiology in KC with bladder pain alone. The majority of patients can enjoy clinical improvement after cessation of ketamine and urological treatment similar to interstitial cystitis/bladder pain syndrome (IC/BPS. However, patients who are still abusing ketamine and/or who have a longer duration of ketamine abuse might suffer from severe bladder pain, which does not respond to empirical oral or intravesical treatments such as hyaluronic acid. Among these patients, most have a remarkably impaired quality of life and are at risk of developing upper urinary tract damage

  5. Renal and urologic emergencies in the HIV-infected patient.

    Science.gov (United States)

    Liang, Stephen Y; Overton, E Turner

    2010-05-01

    Antiretroviral therapy has revolutionized the care of individuals infected with the human immunodeficiency virus (HIV) and has fundamentally altered the scope of the disease. Acute renal failure and chronic kidney disease from medication toxicity and comorbid noninfectious illnesses are just as likely today as end-organ injury from the virus itself. Chronic immunosuppression renders HIV-infected patients vulnerable to any of several unique urological infections not frequently seen in immunocompetent patients. A deeper understanding of renal and urological emergencies in the context of the HIV-infected patient will better prepare the emergency physician to render optimal care to this rapidly expanding and aging patient population.

  6. Genitourinary Prosthetics: A Primer for the Non-urologic Surgeon.

    Science.gov (United States)

    Lavien, Garjae; Zaid, Uwais; Peterson, Andrew C

    2016-06-01

    Genitourinary prosthetics are used for correction of functional deficits and to improve the quality of lives of affected patients. General surgeons must evaluate patients scheduled for nonurologic surgery with urologic devices that can impact their perioperative management. Lack of recognition of these prosthetics preoperatively can lead to unnecessary morbidity for the patient and have legal implications for the surgeon. Close consultation with a urologist may avoid common complications associated with these devices and allows for surgical assistance when operative misadventures do occur. This article reviews 3 common urologic prosthetics: testicular prosthesis, artificial urinary sphincter, and penile prosthesis.

  7. Surgical Management of Urologic Trauma and Iatrogenic Injuries.

    Science.gov (United States)

    Zinman, Leonard N; Vanni, Alex J

    2016-06-01

    Genitourinary trauma usually occurs in the setting of multisystem trauma, accounting for approximately 10% of all emergency department admissions. Timely evaluation and management of the trauma patient have the potential to minimize urologic morbidity and mortality. New imaging modalities and a growing emphasis on nonoperative expectant management of both upper and lower urinary tract injuries have changed the field of urologic trauma. Concomitant injury to both the upper and the lower urinary tract is rare, but careful evaluation is critical to identify these devastating injuries.

  8. Feasibility and safety of augmented reality-assisted urological surgery using smartglass.

    Science.gov (United States)

    Borgmann, H; Rodríguez Socarrás, M; Salem, J; Tsaur, I; Gomez Rivas, J; Barret, E; Tortolero, L

    2017-06-01

    To assess the feasibility, safety and usefulness of augmented reality-assisted urological surgery using smartglass (SG). Seven urological surgeons (3 board urologists and 4 urology residents) performed augmented reality-assisted urological surgery using SG for 10 different types of operations and a total of 31 urological operations. Feasibility was assessed using technical metadata (number of photographs taken/number of videos recorded/video time recorded) and structured interviews with the urologists on their use of SG. Safety was evaluated by recording complications and grading according to the Clavien-Dindo classification. Usefulness of SG for urological surgery was queried in structured interviews and in a survey. The implementation of SG use during urological surgery was feasible with no intrinsic (technical defect) or extrinsic (inability to control the SG function) obstacles being observed. SG use was safe as no grade 3-5 complications occurred for the series of 31 urological surgeries of different complexities. Technical applications of SG included taking photographs/recording videos for teaching and documentation, hands-free teleconsultation, reviewing patients' medical records and images and searching the internet for health information. Overall usefulness of SG for urological surgery was rated as very high by 43 % and high by 29 % of surgeons. Augmented reality-assisted urological surgery using SG is both feasible and safe and also provides several useful functions for urological surgeons. Further developments and investigations are required in the near future to harvest the great potential of this exciting technology for urological surgery.

  9. 21 CFR 876.4730 - Manual gastroenterology-urology surgical instrument and accessories.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Manual gastroenterology-urology surgical... Devices § 876.4730 Manual gastroenterology-urology surgical instrument and accessories. (a) Identification. A manual gastroenterology-urology surgical instrument and accessories is a device designed to...

  10. Urological Surveillance and Medical Complications after Spinal Cord Injury in the United States

    NARCIS (Netherlands)

    Cameron, Anne P.; Lai, Julie; Saigal, Christopher S.; Clemens, J. Quentin; Wijmenga, T. J.

    2015-01-01

    OBJECTIVE To evaluate the national patterns of urologic follow up after spinal cord injury (SCI) and the occurrence and predictors of urological complications. MATERIALS AND METHODS This retrospective cohort study used a 5% sample of Medicare data 2007-2010. The minimum adequate urologic surveillanc

  11. Baseline urologic surgical skills among medical students: Differentiating trainees.

    Science.gov (United States)

    Gupta, Vishaal; Lantz, Andrea G; Alzharani, Tarek; Foell, Kirsten; Lee, Jason Y

    2014-07-01

    Urology training programs seek to identify ideal candidates with the potential to become competent urologic surgeons. It is unclear whether innate technical ability has a role in this selection process. We aimed to determine whether there are any innate differences in baseline urologic technical skills among medical students. Second-year medical students from the University of Toronto were recruited for this study and stratified into surgical and non-surgical cohorts based on their reported career aspirations. After a pre-test questionnaire, subjects were tested on several urologic surgical skills: laparoscopy, cystoscopy and robotic surgery. Statistical analysis was performed using chi-squared test, student t-tests and Spearman's correlation where appropriate. A total of 29 students participated in the study and no significant baseline differences were found between cohorts with respect to demographics and prior surgical experience. For laparoscopic skills, the surgical cohort outperformed the non-surgical cohort on several exercises: Lap Beans Missed (4.9 vs. 9.3, p robotic surgery performance metrics: Task Time (50.6 vs. 76.3, p robotics, may differ between early trainees interested in a surgical career compared to those interested in a non-surgical career. Further studies are required to illicit what impact such differences have on future performance and competence.

  12. [Artificial neural networks for decision making in urologic oncology].

    Science.gov (United States)

    Remzi, M; Djavan, B

    2007-06-01

    This chapter presents a detailed introduction regarding Artificial Neural Networks (ANNs) and their contribution to modern Urologic Oncology. It includes a description of ANNs methodology and points out the differences between Artifical Intelligence and traditional statistic models in terms of usefulness for patients and clinicians, and its advantages over current statistical analysis.

  13. 'Image and treat': an individualized approach to urological tumors

    DEFF Research Database (Denmark)

    Bouchelouche, Kirsten; Capala, Jacek

    2010-01-01

    The current treatment options for advanced urologic cancers demonstrate limited efficacy. To obtain optimal clinical results, there is a need for new, individualized, therapeutic strategies, which have only recently been applied to these malignancies. Nuclear medicine plays an important role in e...

  14. Quality assessment of economic analyses in pediatric urology.

    Science.gov (United States)

    Kokorowski, Paul J; Routh, Jonathan C; Nelson, Caleb P

    2013-02-01

    To describe and evaluate economic analyses or economic evaluations in pediatric urologic literature, including study types such as cost-effectiveness analysis, which are increasingly common in the medical literature. We performed a systematic literature review of the MEDLINE, EMBASE, and Cochrane databases (1990-2011) to identify economic analyses of pediatric urologic topics. Studies were evaluated using published quality metrics. We examined the analysis type, data sources, perspective, methodology, sensitivity analyses, and the reporting of methods, results, limitations, and conclusions. We identified 2945 nonduplicated studies, 60 of which met inclusion criteria. Economic analyses of pediatric urologic topics increased in number during the study period, from 1 study (2%) in 1990 to 7 (12%) in 2010 (P pediatric urologic literature, there is a need for standardization in methods and reporting. Future investigations should attempt to follow standardized reporting guidelines and should pay particular attention to reporting of methods and results, including a comprehensive discussion of limitations. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Tumor banks: the cornerstone of basic research in urology

    Directory of Open Access Journals (Sweden)

    Sabrina T. Reis

    2010-06-01

    Full Text Available PURPOSE: Tumor banks have the primary responsibility for collecting, cataloging, storing and disseminating samples of tissues, cells and fluids, which are used by researchers to identify diagnostic molecular markers, prognostic indicators and therapeutic targets. The objective of this review was to describe a simple, reliable and reproducible protocol for obtaining and storing samples of urological tumors. MATERIALS AND METHODS: Urogenital tumor tissues were collected by the surgeons from the Urology Division of University of Sao Paulo Medical School. The obtained surgical specimens were immediately placed in liquid nitrogen, dry ice or in a tube containing RNAlater ®, and then stored by cryopreservation (-80°C. A mirror fragment was fixed in 10% formalin processed routinely and embedded in Paraplast®. RESULTS: We developed a protocol for the collection, cataloging, storage, conservation and use of tumor samples. During a period of one year the Urological Tumor Bank of the Urology Division stored 274 samples of prostate, bladder, kidney, penis and testicle tumors of different histological types, 74 urine and 271 serum samples. CONCLUSIONS: Having biological materials characterized and available along with the clinical patient information provides an integrated portrait of the patients and their diseases facilitating advances in molecular biology. It also promotes the development of translational research improving methods of diagnosis and cancer treatment.

  16. Acute and chronic urine retention among adults at the urology ...

    African Journals Online (AJOL)

    E.M.T. Yenli

    a Department of Surgery, Urology Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana b Department of ... urine retention with outcomes were recorded on data sheet. .... Accord- ing to the Ghana Statistical Service (GSS), the population trends .... tive and cost effective treatment options for patients with BPE [41]. Various ...

  17. Challenges facing academic urology training programs: an impending crisis.

    Science.gov (United States)

    Gonzalez, Chris M; McKenna, Patrick

    2013-03-01

    To determine the most pressing issues facing academic urology training centers. The supply of urologists per capita in the United States continues to decrease. Stricter resident requirements, restriction of resident duty hours, and a Graduate Medical Education (GME) funding cap on resident education has led to significant challenges for academic centers. A 32-question survey was sent to Society of University Urologists members. Respondents defined themselves as academic faculty tenure track, program director, academic chair, program director and academic chair, clinical faculty nontenure track, and community faculty member. A total of 143 of 446 members(32%) responded. A lack of funding was indicated as an obstacle to adding new residency positions (65% respondents) and recruiting new faculty (60% respondents). Residency positions not funded by GME (40% respondents) required either clinical or hospital dollars to support these slots. Most respondents (51%) indicated resident research rotations are funded with clinical dollars. Surgical skills laboratories are commonly used (85% respondents) and are supported mostly with hospital or clinical dollars. The majority of respondents (84%) indicated they would expand simulation laboratories if they had better funding. Other than urodynamics and ultrasound, urology residency training programs reported little income from ancillary dollars. There is a significant workforce shortage within urology training programs. Clinical revenue and hospital funding seem to be the main financial support engines to supplement the GME funding shortage, proficiency training, and faculty salary support for teaching. The current system of GME funding for urology residency programs is not sustainable. Published by Elsevier Inc.

  18. Laser therapy in the treatment of urological diseases

    Science.gov (United States)

    Nelius, T.; de Riese, W. T.; Reiher, F.; Filleur, S.; Allhoff, E. P.

    2006-02-01

    Applications of lasers (light amplification by stimulated emission of radiation) in various disciplines of medicine including Urology are well developed. Urology is among the medical specialties that apply many different types of laser systems to treat a broad spectrum of clinical conditions ranging from genital, bladder and urethral tumors to the treatment of benign prostate hyperplasia (BPH), urethral strictures, and stones. The specific application of various laser systems depends on the characteristics of the laser itself, delivery media for the beams, laser-tissue interaction and the desired effect. These complex conditions require an intensive and continuous exchange of information between non-medical researchers and physicians to verify "what is currently technically possible and what is medically needed". Only this exchange can lead to the development of new laser systems. While lasers have become the treatment of choice in some conditions, they could not, despite excellent clinical results, replace conventional therapy options in others. Nonetheless, the use and the introduction of lasers of different wavelengths forces urologists to keep step with the fast developing laser technology. This paper reviews current indications for clinical laser applications relevant to urology and the advantages and disadvantages of using lasers for the management of various urological lesions.

  19. Future robotic platforms in urologic surgery: recent developments.

    Science.gov (United States)

    Herrell, S Duke; Webster, Robert; Simaan, Nabil

    2014-01-01

    To review recent developments at Vanderbilt University of new robotic technologies and platforms designed for minimally invasive urologic surgery and their design rationale and potential roles in advancing current urologic surgical practice. Emerging robotic platforms are being developed to improve performance of a wider variety of urologic interventions beyond the standard minimally invasive robotic urologic surgeries conducted currently with the da Vinci platform. These newer platforms are designed to incorporate significant advantages of robotics to improve the safety and outcomes of transurethral bladder surgery and surveillance, further decrease the invasiveness of interventions by advancing LESS surgery, and to allow for previously impossible needle access and ablation delivery. Three new robotic surgical technologies that have been developed at Vanderbilt University are reviewed, including a robotic transurethral system to enhance bladder surveillance and transurethral bladder tumor, a purpose-specific robotic system for LESS, and a needle-sized robot that can be used as either a steerable needle or small surgeon-controlled micro-laparoscopic manipulator.

  20. The spectrum of urological disease in patients with spina bifida.

    LENUS (Irish Health Repository)

    Cahill, R A

    2012-02-03

    BACKGROUND: [corrected] Urological complications are the major cause of ill health during childhood and adult life of patients with spina bifida but the significance of urinary tract disease on the individual and the healthcare services is underemphasised. AIM: To assess the effects of spina bifida on the individual and the healthcare services. METHODS: A retrospective review was performed to assess the frequency and significance of urological conditions requiring hospital attendance in patients with spina bifida currently attending a specialised multidisciplinary clinic over a period of six months. RESULTS: Urinary sepsis accounted for the majority of admissions (62%), while 38 of 62 patients required 60 surgical procedures. Targeting the primary urological abnormality (the dysfunctional and usually poorly compliant bladder) allows implementation of effective treatments, including regular intermittent bladder catherisation (52%) in order to preserve upper renal tract function. Associated postural abnormalities complicated both conservative and interventional therapies. CONCLUSION: This study highlights the surgical commitment for units caring for patients with spina bifida, the important considerations for the future healthcare services, and the range and severity of urological diseases encountered by these patients.

  1. Future robotic platforms in urologic surgery: Recent Developments

    Science.gov (United States)

    Herrell, S. Duke; Webster, Robert; Simaan, Nabil

    2014-01-01

    Purpose of review To review recent developments at Vanderbilt University of new robotic technologies and platforms designed for minimally invasive urologic surgery and their design rationale and potential roles in advancing current urologic surgical practice. Recent findings Emerging robotic platforms are being developed to improve performance of a wider variety of urologic interventions beyond the standard minimally invasive robotic urologic surgeries conducted presently with the da Vinci platform. These newer platforms are designed to incorporate significant advantages of robotics to improve the safety and outcomes of transurethral bladder surgery and surveillance, further decrease the invasiveness of interventions by advancing LESS surgery, and allow for previously impossible needle access and ablation delivery. Summary Three new robotic surgical technologies that have been developed at Vanderbilt University are reviewed, including a robotic transurethral system to enhance bladder surveillance and TURBT, a purpose-specific robotic system for LESS, and a needle sized robot that can be used as either a steerable needle or small surgeon-controlled micro-laparoscopic manipulator. PMID:24253803

  2. Evaluation of urology residents' perception of surgical theater educational environment.

    Science.gov (United States)

    Binsaleh, Saleh; Babaeer, Abdulrahman; Rabah, Danny; Madbouly, Khaled

    2015-01-01

    To evaluate surgical theater learning environment perception in urology residents in Saudi Arabia and to investigate association of learning environment perception and stages of residency program, sectors of health care system, and regions of Saudi Arabia. A cross-sectional survey using the surgical theater educational environment measure (STEEM) inventory. The STEEM inventory was used to measure theater learning environment perception of urology residents in Saudi Arabia. Respondents' perception was compared regarding different residency stages, sectors of the health care system, and regions of Saudi Arabia. Internal reliability of the inventory was assessed using the Cronbach α coefficient. Correlation analysis was done using the Spearman ρ coefficient. Of 72 registered residents, 33 (45.8%) completed the questionnaire. The residents perceived their environment less than acceptable (135.9 ± 16.7, 67.95%). No significant differences in perception were found among residents of different program stages, different sectors of health care system, or different regions in Saudi Arabia. Residents from the eastern region perceived the training and teaching domain better (p = 0.025). The inventory showed a high internal consistency with a Cronbach α of 0.862. STEEM survey is an applicable and reliable instrument for assessing the learning environment and training skills of urology residency program in Saudi Arabia. Urology residents in Saudi Arabia perceived the theater learning environment as less than ideal. The perceptions of theater learning environment did not change significantly among different stages of the program, different sectors of health care system, or different training regions of Saudi Arabia assuring the uniformity of urology training all over Saudi Arabia. The training programs should address significant concerns and pay close attention to areas in surgical theater educational environment, which need development and enhancement, mainly planned fashion

  3. Robotic-assisted laparoscopic surgery: recent advances in urology.

    Science.gov (United States)

    Autorino, Riccardo; Zargar, Homayoun; Kaouk, Jihad H

    2014-10-01

    The aim of the present review is to summarize recent developments in the field of urologic robotic surgery. A nonsystematic literature review was performed to retrieve publications related to robotic surgery in urology and evidence-based critical analysis was conducted by focusing on the literature of the past 5 years. The use of the da Vinci Surgical System, a robotic surgical system, has been implemented for the entire spectrum of extirpative and reconstructive laparoscopic kidney procedures. The robotic approach can be applied for a range of adrenal indications as well as for ureteral diseases, including benign and malignant conditions affecting the proximal, mid, and distal ureter. Current evidence suggests that robotic prostatectomy is associated with less blood loss compared with the open surgery. Besides prostate cancer, robotics has been used for simple prostatectomy in patients with symptomatic benign prostatic hyperplasia. Recent studies suggest that minimally invasive radical cystectomy provides encouraging oncologic outcomes mirroring those reported for open surgery. In recent years, the evolution of robotic surgery has enabled urologic surgeons to perform urinary diversions intracorporeally. Robotic vasectomy reversal and several other robotic andrological applications are being explored. In summary, robotic-assisted surgery is an emerging and safe technology for most urologic operations. The acceptance of robotic prostatectomy during the past decade has paved the way for urologists to explore the entire spectrum of extirpative and reconstructive urologic procedures. Cost remains a significant issue that could be solved by wider dissemination of the technology. Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  4. Current laparoscopy training in urology: a comparison of fellowships governed by the Society of Urologic Oncology and the Endourological Society.

    Science.gov (United States)

    Yap, Stanley A; Ellison, Lars M; Low, Roger K

    2008-08-01

    Laparoscopic surgery is now an integral technique in the practice of urology, particularly in the management of certain urologic malignancies. Advanced laparoscopy training in urology is primarily reserved for those pursuing fellowship training and is offered both by traditional endourology fellowships and increasingly in urologic oncology fellowships. The purpose of our study was to evaluate and compare current laparoscopy training at the fellowship level. A 17-item questionnaire was developed with support from both the Endourological Society (EUS) and Society of Urologic Oncology (SUO). Surveys were sent to program directors of fellowships recognized by the EUS and SUO. Directors were surveyed on the laparoscopic case volume, degree of oncology training, and career choice of their graduates. Data were analyzed with Wilcoxon rank-sum and Student t tests. Our survey had an overall response rate of 60%. Fellows performed more than 100 laparoscopies during their training period in 57% of EUS and 25% of SUO fellowship programs. Similar trends are demonstrated when analyzing robotic procedures, with 73% of EUS fellows performing more than 50 procedures compared with 43% of SUO fellows. The majority (59%) of EUS programs provide oncologic training. Between 44% and 100% of graduates from EUS and SUO fellowships obtain academic positions. The majority of SUO directors (63%) believe that fellowship training in laparoscopy should be provided in fellowships governed solely by the SUO, while 41% of EUS directors believe this training should be governed solely by the EUS. Endourology fellowships currently provide a greater exposure to laparoscopy and robotics than SUO fellowships. The percentage of fellows seeking academic positions is similar for EUS and SUO fellowship programs and has remained stable for several years. Directors of fellowship programs that offer advanced laparoscopic training have divergent views as to which administrative body should govern its future.

  5. Attitude and perception of urology by medical students at the end of their medical school: An appraisal from Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Saleh Binsaleh

    2015-01-01

    Conclusions: Knowledge of medical school graduates is insufficient in many urologic subjects, and there is a need for more urology exposure. Social reasons and lack of knowledge about urology hinder the choice of urology specialty as a future career. Clearance of learning objectives, immediate and prompt feedback on performance and adequate emphasis of common problems and ambulatory care are some aspects that should be taken into account by curriculum planners as they consider improvements to urology rotation program.

  6. The family of Deg/HtrA proteases in plants

    Directory of Open Access Journals (Sweden)

    Schuhmann Holger

    2012-04-01

    Full Text Available Abstract Background The Deg/HtrA family of ATP-independent serine endopeptidases is present in nearly all organisms from bacteria to human and vascular plants. In recent years, multiple deg/htrA protease genes were identified in various plant genomes. During genome annotations most proteases were named according to the order of discovery, hence the same names were sometimes given to different types of Deg/HtrA enzymes in different plant species. This can easily lead to false inference of individual protease functions based solely on a shared name. Therefore, the existing names and classification of these proteolytic enzymes does not meet our current needs and a phylogeny-based standardized nomenclature is required. Results Using phylogenetic and domain arrangement analysis, we improved the nomenclature of the Deg/HtrA protease family, standardized protease names based on their well-established nomenclature in Arabidopsis thaliana, and clarified the evolutionary relationship between orthologous enzymes from various photosynthetic organisms across several divergent systematic groups, including dicots, a monocot, a moss and a green alga. Furthermore, we identified a “core set” of eight proteases shared by all organisms examined here that might provide all the proteolytic potential of Deg/HtrA proteases necessary for a hypothetical plant cell. Conclusions In our proposed nomenclature, the evolutionarily closest orthologs have the same protease name, simplifying scientific communication when comparing different plant species and allowing for more reliable inference of protease functions. Further, we proposed that the high number of Deg/HtrA proteases in plants is mainly due to gene duplications unique to the respective organism.

  7. Ergonomic status of laparoscopic urologic surgery: survey results from 241 urologic surgeons in china.

    Directory of Open Access Journals (Sweden)

    Boluo Liang

    Full Text Available BACKGROUND: The prolonged and frequent use of laparoscopic equipment raises ergonomic risks that may cause physical distress for surgeons. We aimed to assess the prevalence of urologic surgeons' physical distress associated with ergonomic problems in the operating room (OR and their awareness of the ergonomic guidelines in China. METHODS: A sample of 300 laparoscopic urologists in China was assessed using a questionnaire on demographic information, ergonomic issues in the OR, musculoskeletal symptoms, and awareness of the ergonomic guidelines for the OR. RESULTS: There were 241 survey respondents (86.7% with valid questionnaires. Among the respondents, only 43.6% placed the operating table at pubic height during the actual operation. The majority of the respondents (63.5% used only one monitor during the procedure. Only 29.9% placed the monitor below the eye level. More than half of the respondents (50.6% preferred to use manual control instead of the foot pedal. Most of the respondents (95.0% never used the body support. The respondents experienced discomfort in the following regions, in ascending order: leg (21.6%, hand (30.3%, wrist (32.8%, shoulder (33.6%, back (53.1%, and neck (58.1%. The respondents with over 250 total operations experienced less discomfort than those with less than 250 total operations. Most of the respondents (84.6% were unaware of the ergonomic guidelines. However, almost all of the respondents (98.3% regarded the ergonomic guidelines to be important in the OR. CONCLUSIONS: Most of the laparoscopic urologists were not aware of the ergonomic guidelines for the OR; hence, they have been suffering from varying degrees of physical discomfort caused by ergonomic issues. There is an urgent need for education regarding ergonomic guidelines in the OR for laparoscopic urologists in China.

  8. [Urology and Sexology in Berlin 1880-1933: Original citations for the establishment of this frontier of urology - protagonists as reflected in their publications].

    Science.gov (United States)

    Moll, Friedrich H; Fangerau, Heiner

    2016-02-01

    The connections between urology and sexology are often not obvious today. At the end of the 19th century both specialties developed in parallel especially in Berlin and had a fruitful relationship. Urologic journals and books were an ideal forum for publication especially for sexologists.

  9. Stroke management in northern Lombardy: organization of an emergency-urgency network and development of a connection between prehospital and in-hospital settings.

    Science.gov (United States)

    Vidale, Simone; Verrengia, Elena; Gerardi, Francesca; Arnaboldi, Marco; Bezzi, Giacomo; Bono, Giorgio; Guidotti, Mario; Grampa, Giampiero; Perrone, Patrizia; Zarcone, Davide; Zoli, Alberto; Beghi, Ettore; Agostoni, Elio; Porazzi, Daniele; Landriscina, Mario

    2012-08-01

    Stroke is the leading cause of disability in adulthood, and the principal aim of care in cerebrovascular disease is the reduction of this negative outcome and mortality. Several studies demonstrated the efficacy of thrombolytic therapy in ischemic stroke, but up to 80% of cases could not be treated because the diagnostic workup exceeds the time limit. In this article, we described the design of a study conducted in the northern Lombardy, within the district of Sondrio, Lecco, Como, and Varese. The awaited results of this study are reduction of avoidable delay, organization of an operative stroke emergency network, and identification of highly specialized structures. The study schedules education and data registration with implementation and training of acute stroke management algorithms. The use of standardized protocols during prehospital and in-hospital phase can optimize acute stroke pathways. The results of this study could contribute to the assessment of an effective and homogeneous health system to manage acute stroke.

  10. Ground beetles (Coleoptera: Carabidae of rice field banks and restored habitats in an agricultural area of the Po Plain (Lombardy, Italy

    Directory of Open Access Journals (Sweden)

    Nicola Pilon

    2013-11-01

    Full Text Available An entomological investigation was carried out in an agricultural area, mainly rice fields, of the Po river plain, located in the municipalities of Lacchiarella (MI and Giussago (PV (Lombardy, Italy. In 2009 and 2010, ground beetles (Coleoptera: Carabidae were sampled along rice field banks and in restored habitats, by means of pitfall traps. The area appeared as species-rich, compared to other anthropogenic habitats in the Po river pain. Most of the collected Carabids were species with a wide distribution in the Paleartic region, eurytopic and common in European agroecosystems. The assemblages were dominated by small-medium, macropterous species, with summer larvae. No endemic species were found. Species with southern distribution, rarely found north of the Po river, were also sampled. Amara littorea is recorded for the first time in Italy.

  11. Design and construction of translational medicine platform for urologic oncology.

    Science.gov (United States)

    Xu, Yong; Yang, Kuo

    2012-03-01

    Translational medicine is a new medical model which focus on overcoming the serious imbalance among the basic research, its clinical and public health application. Its core is to establish effective ties among basic medical researchers, public health workers and doctors who know the needs of patients, particularly translating the molecular medical research results to suitable disease prevention, diagnosis, treatment and prevention methods effectively. This paper discusses the design and construction of the translational medicine platform for urologic system tumors. However, there is no draw on the precedent, it is a challenging project to create such a complicated platform and make it running smoothly and effectively. Based on the Tianjin Translational Medicine Platform for Urologic Oncology (TTMPUO) which had been established in support of Tianjin Science and Technology Commission, this paper will focus on describing the design ideas and the essential parts of the platform.

  12. Antibiotic resistant urinary tract infections in an urology ward

    Directory of Open Access Journals (Sweden)

    A. Rădulescu

    2015-12-01

    Full Text Available Introduction: UTI (urinary tract infections represent a central pathology for a urological service. Antibiotic resistance is growing at a steady and alarming rate worldwide and especially in Romania. Method and materials: We have analyzed all the patients that were admitted to our clinic for continuous hospitalization between January 2015 and October 2015. All patients undergone urine culture and all cultures positive had an antibiogram worked up. We have selected all patients that had antibiotic resistance to at least an antibiotic. Results: From 1745 patients admitted for continuous hospitalization, we had 180 positive urine cultures at admission from which 125 had at least an antibiotic resistance. Conclusions: Antibiotic resistance is a serious phenomenon, with potential lethal complications, which we encounter daily in urological practice.

  13. Robot-assisted laparoscopic urological surgery in children.

    Science.gov (United States)

    Sávio, Luís F; Nguyen, Hiep T

    2013-11-01

    Robot-assisted laparoscopic surgery (RALS) has been proven to be safe and effective for various urological procedures in children, including pyeloplasty, orchiopexy, nephrectomy, and bladder augmentation. The robot system enables delicate and precise movements, which are ideal for the types of reconstructive surgeries that children with urological issues often require, overcoming many of the impediments associated with the conventional laparoscopic approach. RALS helps the relative novice to perform fine surgical techniques and is thought to reduce the learning curve associated with some surgical techniques, such as intracorporeal suturing, owing to the improved freedom of movement of the surgical instruments, the ergonomic positioning of the surgeon, and the 3D vision provided by the robotic system. Given the favourable safety profile and associated benefits of the robot system, including reductions in mean postoperative hospital stay compared with conventional procedures, RALS is becoming more widely adopted by paediatric urologists.

  14. Application of Virtual, Augmented, and Mixed Reality to Urology.

    Science.gov (United States)

    Hamacher, Alaric; Kim, Su Jin; Cho, Sung Tae; Pardeshi, Sunil; Lee, Seung Hyun; Eun, Sung-Jong; Whangbo, Taeg Keun

    2016-09-01

    Recent developments in virtual, augmented, and mixed reality have introduced a considerable number of new devices into the consumer market. This momentum is also affecting the medical and health care sector. Although many of the theoretical and practical foundations of virtual reality (VR) were already researched and experienced in the 1980s, the vastly improved features of displays, sensors, interactivity, and computing power currently available in devices offer a new field of applications to the medical sector and also to urology in particular. The purpose of this review article is to review the extent to which VR technology has already influenced certain aspects of medicine, the applications that are currently in use in urology, and the future development trends that could be expected.

  15. Application of Virtual, Augmented, and Mixed Reality to Urology

    Science.gov (United States)

    2016-01-01

    Recent developments in virtual, augmented, and mixed reality have introduced a considerable number of new devices into the consumer market. This momentum is also affecting the medical and health care sector. Although many of the theoretical and practical foundations of virtual reality (VR) were already researched and experienced in the 1980s, the vastly improved features of displays, sensors, interactivity, and computing power currently available in devices offer a new field of applications to the medical sector and also to urology in particular. The purpose of this review article is to review the extent to which VR technology has already influenced certain aspects of medicine, the applications that are currently in use in urology, and the future development trends that could be expected. PMID:27706017

  16. Identifying content for simulation-based curricula in urology

    DEFF Research Database (Denmark)

    Nayahangan, Leizl Joy; Bølling Hansen, Rikke; Lindorff-Larsen, Karen

    2017-01-01

    to identify technical procedures in urology that should be included in a simulation-based curriculum for residency training. MATERIALS AND METHODS: A national needs assessment was performed using the Delphi method involving 56 experts with significant roles in the education of urologists. Round 1 identified......OBJECTIVE: Simulation-based training is well recognized in the transforming field of urological surgery; however, integration into the curriculum is often unstructured. Development of simulation-based curricula should follow a stepwise approach starting with a needs assessment. This study aimed...... technical procedures that newly qualified urologists should perform. Round 2 included a survey using an established needs assessment formula to explore: the frequency of procedures; the number of physicians who should be able to perform the procedure; the risk and/or discomfort to patients when a procedure...

  17. Optimal management of urosepsis from the urological perspective.

    Science.gov (United States)

    Wagenlehner, Florian M E; Weidner, Wolfgang; Naber, Kurt G

    2007-11-01

    Urosepsis in adults comprises approximately 25% of all sepsis cases and in most cases is due to complicated urinary tract infections (UTIs). In this paper we review the optimal management of urosepsis from the urological point of view. Urosepsis is often due to obstructed uropathy of the upper or lower urinary tract. The treatment of urosepsis comprises four major aspects: 1. Early goal-directed therapy; 2. Optimal pharmacodynamic exposure to antimicrobials both in blood and in the urinary tract; 3. Control of complicating factors in the urinary tract; 4. Specific sepsis therapy. Early tissue oxygenation, appropriate initial antibiotic therapy and rapid identification and control of the septic focus in the urinary tract are critical steps in the successful management of a patient with severe urosepsis. To achieve this goal an optimal interdisciplinary approach encompassing the emergency unit, urological specialties and intensive-care medicine is necessary.

  18. Nuclear medicine in urological cancers: what is new?

    Science.gov (United States)

    Nanni, Cristina; Zanoni, Lucia; Fanti, Stefano

    2014-10-01

    The diffusion of PET/computed tomography has opened up a new role for nuclear imaging in urological oncology. Prostate cancer is evaluated with choline ((11)C or (18)F) PET due to a lack of sensitivity of (18)F-fluorodeoxyglucose (FDG). However, many new tracers, such as (18)F-fluorocyclobutane-1-carboxylic acid and (68)Ga-prostate-specific membrane antigen, are under investigation, offering promising results in the particular setting of radically treated patients with biochemical relapse. The performance of (18)F-FDG depends on the histological type; indeed, renal cell cancer may present variable metabolic uptake. In this field, mainly antibodies labeled with positron emitters are under clinical evaluation. Finally, (18)F-FDG PET/computed tomography has been proven to show good accuracy in detecting metastatic testicular and bladder cancers, despite not having valid results in detecting local disease. The urological cancer diagnostic process is currently under continuous development.

  19. Limiting Global Warming to 2 deg C and Beyond

    Science.gov (United States)

    Lea, D. W.

    2011-12-01

    This presentation addresses the question of how feasible is it to limit global warming to a specific temperature rise, whether 1.5, 2 or 3 deg C. Inherent in the idea of limiting global warming to a specific temperature level is the notion that future GHG emissions will be subject to a top-down international agreement. In the post-Copenhagen era, however, such an agreement is unlikely, and a bottoms-up approach of national pledges will likely have to serve as a surrogate for achieving emissions reduction. In this case, an additional question is what temperature targets are realistic under scenarios that are bounded by achievable national pledges as opposed to binding mandates. The question of feasibility depends largely on future emission pathways of CO2, other GHGs, black carbon and aerosols. Those pathways depend on many societal, technological and economic factors, but it is likely that the ultimate limiting factor is the maximum possible rate of absolute emission reduction. That rate is limited by how rapidly energy infrastructure can be turned over. Most studies suggest that an absolute emission reduction rate of 3.5% is the highest rate achievable. Climate sensitivity and the current cooling effect of aerosols and earth system responses such as the rate of ocean heat uptake and carbon cycle feedbacks determine how a specific emissions pathway translates into probable climate change. A useful framework for CO2 alone is provided by the newly emerging paradigm of cumulative emissions, which holds that peak temperature can be largely predicted by the total amount of carbon emitted, regardless of pathway. Most studies suggest that 1 Tt of cumulative carbon is equivalent to ~2 deg of peak warming. A consideration of these factors suggests that limiting warming to 1.5 deg C is no longer possible under any feasible economic scenario. For one, currently emitted GHGs are equivalent to a ~1.3 deg C warming commitment. This leaves very little room for future emissions

  20. [Cyclooxygenase 2 inhibitors and urologic and gynaecologic cancers].

    Science.gov (United States)

    Eschwege, Pascal

    2004-05-01

    PGE2 is one of the most important prostaglandin involved in the oncogenesis. PGE2 is found at high concentration level in the most of epithelial cancer. Urologic and gynaecologic cancer express the enzyme which are at the origin of PGE2: cyclooxygenase 2. Cox2 inhibitors present anticancer properties demonstrated in wide varieties of cellular and animal models. Human applications are currently tested in many clinical trials for bladder, prostate and uterine carcinomas.

  1. Urologic robotic surgery in Korea: Past and present

    OpenAIRE

    Seo, Ill Young

    2015-01-01

    Since 2005 when the da Vinci surgical system was approved as a medical device by the Korean Ministry of Health and Welfare, 51 systems have been installed in 40 institutions as of May 2015. Although robotic surgery is not covered by the national health insurance service in Korea, it has been used in several urologic fields as a less invasive surgery. Since the first robotic-assisted laparoscopic radical prostatectomy in 2005, partial nephrectomy, radical cystectomy, pyeloplasty, and other uro...

  2. The emerging use of Twitter by urological journals.

    Science.gov (United States)

    Nason, Gregory J; O'Kelly, Fardod; Kelly, Michael E; Phelan, Nigel; Manecksha, Rustom P; Lawrentschuk, Nathan; Murphy, Declan G

    2015-03-01

    To assess the emerging use of Twitter by urological journals. A search of the Journal of Citation Reports 2012 was performed to identify urological journals. These journals were then searched on Twitter.com. Each journal website was accessed for links to social media (SoMe). The number of 'tweets', followers and age of profile was determined. To evaluate the content, over a 6-month period (November 2013 to April 2014), all tweets were scrutinised on the journals Twitter profiles. To assess SoMe influence, the Klout score of each journal was also calculated. In all, 33 urological journals were identified. Eight (24.2%) had Twitter profiles. The mean (range) number of tweets and followers was 557 (19-1809) and 1845 (82-3692), respectively. The mean (range) age of the twitter profiles was 952 (314-1758) days with an average 0.88 tweets/day. A Twitter profile was associated with a higher mean impact factor of the journal (mean [sd] 3.588 [3.05] vs 1.78 [0.99], P = 0.013). Over a 6-month period, November 2013 to April 2014, the median (range) number of tweets per profile was 82 (2-415) and the median (range) number of articles linked to tweets was 73 (0-336). Of these 710 articles, 152 were Level 1 evidence-based articles, 101 Level 2, 278 Level 3 and 179 Level 4. The median (range) Klout score was 47 (19-58). The Klout scores of major journals did not exactly mirror their impact factors. SoMe is increasingly becoming an adjunct to traditional teaching methods, due to its convenient and user-friendly platform. Recently, many of the leading urological journals have used Twitter to highlight significant articles of interest to readers. © 2014 The Authors. BJU International © 2014 BJU International.

  3. Reprocessing and reuse of urological armamentarium: How correct are we!

    Directory of Open Access Journals (Sweden)

    Krutik Vipulbhai Raval

    2017-01-01

    Full Text Available Healthcare is expensive for a large proportion of the population in spite of high per capita income and good health insurance penetration. In an effort to reduce cost of the procedure, reprocessing of devices was started in the late 1970s. Reprocessing practice includes various measures such as proper cleaning, disinfection, and sterilization procedures. As reprocessing is aimed at reducing cost, there is a potential risk of compromising patient safety due to cross contamination after inadequate sterilization. There is also risk of performance alteration of urological reprocessed devices during sterilization/disinfection processing. Therefore, there is a need for formulating proper guidelines to decide methods of reprocessing for various urological equipment. There is also need to discuss the problematic areas that urologists face and to find their solutions. A PubMed search was made in September 2016, using key words “reprocessing of medical devices,” “Single Use Devices,” “methods of reprocessing of devices in clinical practice,” “use of formalin chamber,” “urological disposable sterilization,” etc., After excluding duplicates, all English articles were reviewed by title and abstract. Full texts of selected articles were obtained, and these articles were cross-referenced to find any other related articles. All the articles were reviewed. A product can be reused if it can be economically reprocessed with validated protocols with preservation of its function. There is no reason to discard it after one use. This practice is useful for controlling economics of a urological case and to reduce the financial burden. Current Food and Drug Administration guidelines are stringent. The contamination described to test the sterilization process in the suggested guidelines actually does never exist in clinical practice. Therefore, new guidelines considering the clinical practice scenario are desirable.

  4. Surgical site infection rates following laparoscopic urological procedures.

    Science.gov (United States)

    George, Arvin K; Srinivasan, Arun K; Cho, Jane; Sadek, Mostafa A; Kavoussi, Louis R

    2011-04-01

    Surgical site infections have been categorized by the Centers for Medicare and Medicaid Services as "never events". The incidence of surgical site infection following laparoscopic urological surgery and its risk factors are poorly defined. We evaluated surgical site infection following urological laparoscopic surgery and identified possible factors that may influence occurrence. Patients who underwent transperitoneal laparoscopic procedures during a 4-year period by a single laparoscopic surgeon were retrospectively reviewed. Surgical site infections were identified postoperatively and defined using the Centers for Disease Control criteria. Clinical parameters, comorbidities, smoking history, preoperative urinalysis and culture results as well as operative data were analyzed. Nonparametric testing using the Mann-Whitney U test, multivariable logistic regression and Spearman's rank correlation coefficient were used for data analysis. In 556 patients undergoing urological laparoscopic procedures 14 surgical site infections (2.5%) were identified at mean postoperative day 21.5. Of the 14 surgical site infections 10 (71.4%) were located at a specimen extraction site. Operative time, procedure type and increasing body mass index were significantly associated with the occurrence of surgical site infections (p = 0.007, p = 0.019, p = 0.038, respectively), whereas history of diabetes mellitus (p = 0.071) and intraoperative transfusion (p = 0.053) were found to trend toward significance. Age, gender, positive urine culture, steroid use, procedure type and smoking history were not significantly associated with surgical site infection. Body mass index and operative time remained significant predictors of surgical site infection on multivariate logistic regression analysis. Surgical site infection is an infrequent complication following laparoscopic surgery with the majority occurring at the specimen extraction site. Infection is associated with prolonged operative time and

  5. Use of a semiconductor-diode laser in urology

    Science.gov (United States)

    Watson, Graham M.

    1994-05-01

    The gallium arsenide semiconductor laser can emit in the near infrared where the depth of penetration into tissue is great although scattering is less than with the Nd:YAG laser. The laser is highly compact. It runs off a normal electrical outlet with no cooling requirement. It is therefore quiet and convenient. The laser has been assessed in a wide variety of applications in our urological department.

  6. Early urologic considerations in patients with persistent cloaca.

    Science.gov (United States)

    VanderBrink, Brian A; Reddy, Pramod P

    2016-04-01

    Cloacal malformations represent one of the most complex conditions among anorectal malformations. Urologic conditions occur with an increased frequency in cloaca patients compared to patients with other types of ARM. The morbidity of the upper and lower urinary tract dysfunction/malformations at times can be severe; manifested by urinary tract infection, lower urinary tract symptoms, urinary incontinence, chronic kidney disease, and even end stage renal disease. Long-term follow-up of patients with cloaca has described significant chronic kidney disease and end-stage renal disease. Whether this rate of chronic kidney disease is a function of intrinsic renal dysplasia or acquired renal injury from neurogenic bladder is currently unknown. However, it is well known that severe lower urinary tract dysfunction, no matter the etiology, poses significant risk to the upper tracts when untreated. Neonatal assessment of the urinary tract accompanied by early identification of abnormal structure and function is therefore fundamental to minimize the impact of any urologic condition on the child's overall health. Adequate management of any associated bladder dysfunction is essential to preserving renal function, minimizing risk of urinary tract infection, and potentially avoiding need for future reconstructive surgery. This article summarizes our institution's approach to the ongoing early urologic management in patients with cloaca. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Manipulating the epigenome for the treatment of urological malignancies.

    LENUS (Irish Health Repository)

    O'Rourke, Colm J

    2013-05-01

    Urological malignancies (cancers of the prostate, bladder, kidney and testes) account for 15% of all human cancers and more than 500,000 deaths worldwide each year. This group of malignancies is spread across multiple generations, affecting the young (testicular) through middle and old-age (kidney, prostate and bladder). Like most human cancers, urological cancers are characterized by widespread epigenetic insult, causing changes in DNA hypermethylation and histone modifications leading to silencing of tumor suppressor genes and genomic instability. The inherent stability yet dynamic plasticity of the epigenome lends itself well to therapeutic manipulation. Epigenetic changes are amongst the earliest lesions to occur during carcinogenesis and are essentially reversible (unlike mutations). For this reason, much attention has been placed over the past two decades on deriving pharmacological compounds that can specifically target and reverse such epi-mutations, either halting cancer on its developmental trajectory or reverting fully formed cancers to a more clinically manageable state. This review discusses DNA methyltransferase and histone deacetylase inhibitors that have been extensively studied in preclinical models and clinical trials for advanced and metastatic urological cancers.

  8. [Urologic surgery and risks of complaints in medical responsibility].

    Science.gov (United States)

    Haillot, O; Haertig, A; Vannier, J; Janin, P; Lanson, Y

    1989-01-01

    The card-index study of specialized insurance companies allowed the analysis of 82 cases concerning urological surgical procedures. Forty-two cases went to the Civil Court, 10 to the Penal Court and 5 to the Administrative Tribunal, while 5 cases were simply declared to insurance companies without judiciary consequences. Sixty-two cases concerned private plaintiffs surgeons and 34 cases concerned non specialist urologic surgeons. Sixteen plaintiffs were compensated, 9 after a conciliatory agreement and 7 after trial. There were no penal condemnations (one case on the waiting list). Impotence was the most frequent cause for complaint which was compensated. Next, came incontinence generally secondary to endoscopic resection. Retrospectively, 19 cases seemed to be unwarranted due to the dishonesty of patients (3 patients were prosecuted for unwarranted procedures). On the other hand, 32 cases seemed to be due to a lack of information given to the patients themselves or to their families, either before of after the incriminated act. The risk of prosecution is relatively low in urology. It could be decreased by careful management of the medical chart, by rapid analysis of complications and by a constant effort to inform the patient and his family.

  9. [Transparency regime: semiotics of radiographical images in urological diagnostics].

    Science.gov (United States)

    Martin, M; Fangerau, H

    2012-10-01

    Shortly after Röntgen discovered x-rays urology became one of the main test fields for the application of this new technology. Initial scepticism among physicians, who were inclined to cling to traditional manual methods of diagnosing, was replaced by enthusiasm for radiographic technologies and the new method soon became the standard in, for example the diagnosis of concrements. Patients favoring radiographic procedures over the use of probes and a convincing documentation of stones in radiograms were factors that impacted the relatively rapid integration of radiology into urology. The radiographic representation of soft tissues and body cavities was more difficult and the development of contrast agents in particular posed a serious problem. Several patients died during this research. A new diagnostic dimension was revealed when radiography and cystography were combined to form the method of retrograde pyelography. However, the problem of how urologists could learn how to read the new images remained. In order to allow trainee physicians to practice interpreting radiograms atlases were produced which offered explanatory texts and drawings for radiographic images of the kidneys, the bladder etc. Thus, urologists developed a self-contained semiotics which facilitated the appropriation of a unique urological radiographical gaze.

  10. [De novo urologic tumors in kidney transplant patients].

    Science.gov (United States)

    Rodríguez Faba, O; Breda, A; Gausa, L; Palou, J; Villavicencio, H

    2015-03-01

    The ability of a transplant recipient to accept a graft depends on the ability of immunosuppressive drugs to regulate the immune system. Such treatments have been associated with tumor promotion and progression. A systematic literature review was carried out. Electronic searches were performed in PubMed database. The searching criterion was "urological tumors in kidney transplant recipients". The most important issues regarding incidence, urological tumor-specific features, and relevant ones about the treatment are summarized. In renal transplant, 15% of all tumors are urological neoplasias; furthermore, they are the leading neoplastic cause of death. In transplant population the incidence rate of renal cell carcinoma (RCC), transitional cell bladder carcinoma (TCBC), testicular carcinoma (TC) and prostate cancer are increased 15, 3, 3 and 2 times respectively. Treatments used in transplant patients are similar to those employed in the general population:radical nephrectomy for the native kidney and conservative surgery for the graft are indicated for RCC. Radical prostatectomy is technically feasible for localized PC.Regarding to transitional cell carcinoma BCG or MMC is not contraindicated. The incidence rate of cancer has increased among transplant population. These tumors can be managed following the same criteria than in general population. Because in this population the prognosis is worse for the immunosuppression, closer monitoring is required. Copyright © 2014 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Tropospheric ozone over a tropical Atlantic station in the Northern Hemisphere: Paramaribo, Surinam (6 deg N, 55 deg W)

    Energy Technology Data Exchange (ETDEWEB)

    Peters, W.; Krol, M.C. [Inst. for Marine and Atmospheric Research Utrecht (Netherlands); Fortuin, J.P.F.; Kelder, H.M. [Koninklijke Nederlandse Meteorologische Dienst, De Bilt (Netherlands); Thompson, A.M. [Goddard Space Flight Center, NASA, Greenbelt, MD (United States); Becker, C.R. [Meteorologische Dienst Suriname, Paramaribo (Suriname); Lelieveld, J.; Crutzen, P.J. [Max Planck Inst. fuer Chemie, Mainz (Germany)

    2004-02-01

    We present an analysis of 2.5 yr of weekly ozone soundings conducted at a new monitoring station in Paramaribo, Surinam (6 deg N, 55 deg W). This is currently one of only three ozone sounding stations in the Northern Hemisphere (NH) tropics, and the only one in the equatorial Atlantic region. Paramaribo is part of the Southern Hemisphere Additional Ozone Sounding program (SHADOZ). Owing to its position close to the equator, the inter-tropical convergence zone (ITCZ) passes over Paramaribo twice per year, which results in a semi-annual seasonality of many parameters including relative humidity and ozone. The dataset from Paramaribo is used to: (1) evaluate the ozone variability relative to precipitation, atmospheric circulation patterns and biomass burning; (2) contrast ozone at the NH equatorial Atlantic with that at nearby Southern Hemisphere (SH) stations Natal (6 deg S, 35 deg W) and Ascension (8 deg S, 14 deg W); (3) compare the seasonality of tropospheric ozone with a satellite-derived ozone product: tropical tropospheric ozone columns from the modified residual method (MR-TTOC). We find that Paramaribo is a distinctly Atlantic station. Despite its position north of the equator, it resembles nearby SH stations during most of the year. Transport patterns in the lower and middle troposphere during February and March differ from SH stations, which leads to a seasonality of ozone with two maxima. MR-TTOC over Paramaribo does not match the observed seasonality of ozone due to the use of a SH ozone sonde climatology in the MR method. The Paramaribo ozone record is used to suggest an improvement for Northern Hemisphere MR-TTOC retrievals. We conclude that station Paramaribo shows unique features in the region, and clearly adds new information to the existing SHADOZ record.

  12. Radio identification of decameter-wave sources. II: The 30degdeg declination interval

    CERN Document Server

    Verkhodanov, O V; Andernach, H; 10.1134/S1990341309010052

    2009-01-01

    This paper is dedicated to the identification of decameter-wave sources of the UTR catalog within declination interval 30degdeg. UTR sources are cross-identified with CATS database catalogs within 40'x40' error boxes. The sources are deblended using the data on the coordinates of the objects and the behavior of their continuum radio spectra. The spectra of 876 sources are derived and fitted by standard analytical functions. Of these sources, 221 objects have straight-line spectra with spectral indices alpha<-1.0. All objects are catalogued and stored in the CATS database.

  13. Antibiotic prophylaxis for transurethral urological surgeries: Systematic review

    Directory of Open Access Journals (Sweden)

    Basim S Alsaywid

    2013-01-01

    Full Text Available The use of antibiotic prophylaxis to prevent urinary tract infection and bacteremia (sepsis following endoscopic urologic procedures is a controversial topic. Evidence in the literature revealed that urological instrumentation is associated with increased incidence of urinary tract infection and bacteremia. The aim of this review is to evaluate the effectiveness of antibiotic prophylaxis in reducing the risk of urinary tract infection in patients who had transurethral urological surgeries. We have selected all RCTs of adult population who underwent all different types of transurethral urological surgery, including cystoscopy, transurethral resection of prostate and transurethral resection of bladder tumor, and received prophylactic antibiotics or placebo/no treatment. At first, more than 3000 references were identified and reviewed; of which 42 studies with a total of 7496 patients were included in the final analysis. All those trials were analyzing antibiotic prophylaxis versus placebo/no treatment, and they were significantly favoring antibiotic use in reducing all outcomes, including bacteriuria (RR 0.36, 95% CI 0.29 to 0.46, P < 0.0001 with moderate heterogeneity detected (I 2 48%, symptomatic UTI (RR 0.38, 95% CI 0.28 to 0.51, P < 0.0001 with no significant heterogeneity was detected (I 2 = 17%, bacteremia (RR 0.43, 95% CI 0.23 to 0.82, P < 0.0001 with no noted heterogeneity (I 2 = 0%, and fever ≥38.5 Celsius (RR 0.41, 95% CI 0.23 to 0.73, P = 0.003; also, there was no noted heterogeneity (I 2 = 0%. However, using antibiotic prophylaxis did not reduce the incidence of low grade temperature (RR 0.82, 95% CI 0.61 to 1.11, P = 0.20 or in moderate grade temperature (RR 1.03, 95% CI 0.71 to 1.48, P = 0.89. Antibiotic prophylaxis appears to be an effective intervention in preventing urinary tract infections and its sequels following transurethral urological surgeries in patients with preoperative sterile urine.

  14. Women in Urology Residency, 1978-2013: A Critical Look at Gender Representation in Our Specialty.

    Science.gov (United States)

    Halpern, Joshua A; Lee, Una J; Wolff, Erika M; Mittal, Sameer; Shoag, Jonathan E; Lightner, Deborah J; Kim, Soo; Hu, Jim C; Chughtai, Bilal; Lee, Richard K

    2016-06-01

    To evaluate changes over time in female representation among urology residents compared to those within other specialties. Urology match data were obtained from the American Urological Association from 1996 to 2015. Trends in match rates of male and female urology applicants were assessed. Data for gender representation among residencies were extracted from reports in the Journal of the American Medical Association from 1978 to 2013. We compared the annual percentage of women among urology residents vs residents of other specialties over time. Mean number of male vs female urology applicants per year was 285.0 ± 27.1 vs 76.5 ± 21.8 (P women, respectively (80.7% and 13.5%). The largest growth occurred in urology among all other specialties (P women among all specialties during the study period, women have remained a minority among urology residents. Gender representation within urology is a reflection of many factors and demonstrates a need for further improvement. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Surgical management of bone metastases from urological malignancies: an analysis of 70 cases

    National Research Council Canada - National Science Library

    Toğral, Güray; Arıkan, Murat; Aktaş, Erdem; Öztürk, Recep; Güven, Oğuz; Eksioğlu, Fatih

    2015-01-01

    ... (blastic, mixed, lytic), type of surgical reconstruction, systemic affections, and visceral organ metastasis for 70 bone metastases from deceased urological malignancies patients (55 male, 15 female...

  16. Embrittlement of reduced-activation ferritic/martensitic steels irradiated in HFIR at 300 deg. C and 400 deg. C

    Energy Technology Data Exchange (ETDEWEB)

    Klueh, R.L. E-mail: ku2@ornl.gov; Sokolov, M.A.; Shiba, K.; Miwa, Y.; Robertson, J.P

    2000-12-01

    Miniature tensile and Charpy specimens of four ferritic/martensitic steels were irradiated at 300 deg. C and 400 deg. C in the high flux isotope reactor (HFIR) to a maximum dose of {approx}12 dpa. The steels were standard F82H (F82H-Std), a modified F82H (F82H-Mod), ORNL 9Cr-2WVTa, and 9Cr-2WVTa-2Ni, the 9Cr-2WVTa containing 2% Ni to produce helium by (n,{alpha}) reactions with thermal neutrons. More helium was produced in the F82H-Std than the F82H-Mod because of the presence of boron. Irradiation embrittlement in the form of an increase in the ductile-brittle transition temperature ({delta}DBTT) and a decrease in the upper-shelf energy (USE) occurred for all the steels. The two F82H steels had similar {delta}DBTTs after irradiation at 300 deg. C, but after irradiation at 400 deg. C, the {delta}DBTT for F82H-Std was less than for F82H-Mod. Under these irradiation conditions, little effect of the extra helium in the F82H-Std could be discerned. Less embrittlement was observed for 9Cr-2WVTa steel irradiated at 400 deg. C than for the two F82H steels. The 9Cr-2WVTa-2Ni steel with {approx}115 appm He had a larger {delta}DBTT than the 9Cr-2WVTa with {approx}5 appm He, indicating a possible helium effect.

  17. History of urology in Iwów (Lemberg, Lviv). the impact of political changes on progress in urology and medicine.

    Science.gov (United States)

    Zajaczkowski, Tadeusz

    2013-01-01

    Innovations in diagnostic techniques due to the introduction of endoscopy, and the development in X-ray technology were fundamental in lessening dependence on surgery, and for urology to be recognised as a new discipline. Afterwards, endoscopic surgery came to the fore. Urology in Lemberg, The aim of the study is to present the development of urology in Lemberg as an independent speciality, and its separation from surgery. Well-known Lemberg surgeons who were interested in surgery of the genitourinary system are discussed. The beginning of urology and its development within the framework of surgical departments, and as an independent facility in the interwar period is described. The fate of the Polish department of urology during the interwar period and the World War II is also presented. The development of Ukrainian urology after the World War II is also described. Extensive research was undertaken to collect the literature and documents in Polish and German archives and libraries in order to prepare this study. The author also presents the leading Ukrainian urologists who contributed from the post war period to the last 22 years of free Ukraine (from December 1991), and discusses the development of modern urology in Lviv today.

  18. Modello metodologico per il monitoraggio degli incidenti stradali in Trentino

    Directory of Open Access Journals (Sweden)

    P. Fateh-Moghadam

    2003-05-01

    Full Text Available

    Obiettivi: realizzazione di un’infrastruttura informatica, per l’unificazione tempestiva dei flussi sugli incidenti stradali (ISTAT-ACI e sanitari con la georeferenziazione degli eventi a partire dall’anno 2000.

    Materiali e Metodi: dall’archivio di Trentino emergenza sono stati estratti gli interventi per incidente stradale selezionando la combinazione: descrizione patologica: “traumatismi”, tipologia luogo: “strada”, tipologia incidente. Dai dati di ogni Pronto soccorso è stato costruito un archivio unico contenente il totale degli accessi e sono stati estratti gli accessi per “incidente stradale” e quelli per lesioni accidentali in generale. Dall’archivio SDO si sono selezionati sia i ricoveri con il criterio “3” alla variabile mtraav (=incidente stradale che quelli per traumatismi.

    Nell’ambito del progetto “Metodi informatici predittivi per la mitigazione del rischio da incidenti stradali” (Mitris, finanziato dal Ministero della Salute, è stata realizzata l’immissione tramite interfaccia internet o decodifica automatica dei verbali informatizzati delle Forze dell’ordine, e la contestuale realizzazione di un interfaccia WebGIS
    in grado di visualizzare la localizzazione degli incidenti stradali.

    Risultati: tramite la combinazione “data nascita”,
    “data incidente”, “sesso” è stato eseguito un primo collegamento tra gli archivi. Aggiungendo alla data incidente uno o più giorni, è stato costruito un nuovo archivio PS contenente il 97,4% degli eventi raccolti dalle forze dell’Ordine e contenuti nel data base Mitris. Approccio analogo è stato seguito per il linkage con SDO e 118. Tramite interfaccia WebGIS è stata creata una mappa degli incidenti interrogabile on-line, che oltre alla semplice localizzazione riporta dinamica e esiti con possibilità di produrre statistiche e grafici. Il sistema copre attualmente

  19. Immagini dinamiche: appunti per un catalogo degli usi didattici

    Directory of Open Access Journals (Sweden)

    Filippo Bruni

    2013-03-01

    Full Text Available Le immagini dinamiche costituiscono un’importante risorsa per le attività didattiche. A partire da una riflessione storica, si evidenzia in primo luogo l’importanza di un loro uso efficace alla luce della classificazione operata da Clark e Lyons. In secondo luogo si segnalano alcune attività emergenti legate alla documentazione, al digital storytelling e alla formazione degli insegnanti.

  20. Adverse events resulting from lasers used in urology.

    Science.gov (United States)

    Althunayan, Abdulaziz M; Elkoushy, Mohamed A; Elhilali, Mostafa M; Andonian, Sero

    2014-02-01

    To collate world reports of adverse events (AEs) resulting from lasers used in urology. The Manufacturer and User Facility Device Experience (MAUDE) database of the United States Food and Drug Administration (FDA) was searched using the term "Laser for gastro-urology use." In addition, the Rockwell Laser Industries (RLI) Laser Accident Database was searched for the following types of lasers: neodymium-doped yttrium aluminum garnet (Nd:YAG), holmium:yttrium aluminum garnet (Ho:YAG), potassium titanyl phosphate (KTP), diode and thulium:YAG (Tm:YAG). Both databases were last accessed on October 1, 2012. Overall, there were 433 AEs; 166 in MAUDE database (1992-2012) and 267 in RLI database (1964-2005). Most of the AEs (198/433 or 46%) resulted from generator failure or fiber tip breaking. Whereas there were 20 (4.6%) AEs harming medical operators, there were 159 (37%) AEs harming nonmedical operators using Nd:YAG, KTP, and diode lasers. Eye injuries ranging from mild corneal abrasions to total vision loss were reported in 164 AEs with the use of Nd:YAG, KTP, and diode lasers. Overall, there were 36 (8.3%) AEs resulting in patient harm, including 7 (1.6%) mortalities, 3 deaths from ureteral perforation using the Ho:YAG laser, and 4 deaths from air emboli using the Nd:YAG laser. Other reported patient injuries included bladder perforation resulting in urinary diversion in a patient, in addition to minor skin burns, internal burns, and bleeding in others. There were no AEs reported with the use of Tm:YAG laser. Most of the AEs reported relate to equipment failure. There were no eye injuries reported with the use of Ho:YAG lasers. Caution must be exercised when using lasers in urology, including wearing appropriate eye protection when using Nd:YAG, KTP, and diode lasers.

  1. Augmented reality assisted surgery: a urologic training tool.

    Science.gov (United States)

    Dickey, Ryan M; Srikishen, Neel; Lipshultz, Larry I; Spiess, Philippe E; Carrion, Rafael E; Hakky, Tariq S

    2016-01-01

    Augmented reality is widely used in aeronautics and is a developing concept within surgery. In this pilot study, we developed an application for use on Google Glass ® optical head-mounted display to train urology residents in how to place an inflatable penile prosthesis. We use the phrase Augmented Reality Assisted Surgery to describe this novel application of augmented reality in the setting of surgery. The application demonstrates the steps of the surgical procedure of inflatable penile prosthesis placement. It also contains software that allows for detection of interest points using a camera feed from the optical head-mounted display to enable faculty to interact with residents during placement of the penile prosthesis. Urology trainees and faculty who volunteered to take part in the study were given time to experience the technology in the operative or perioperative setting and asked to complete a feedback survey. From 30 total participants using a 10-point scale, educational usefulness was rated 8.6, ease of navigation was rated 7.6, likelihood to use was rated 7.4, and distraction in operating room was rated 4.9. When stratified between trainees and faculty, trainees found the technology more educationally useful, and less distracting. Overall, 81% of the participants want this technology in their residency program, and 93% see this technology in the operating room in the future. Further development of this technology is warranted before full release, and further studies are necessary to better characterize the effectiveness of Augmented Reality Assisted Surgery in urologic surgical training.

  2. Augmented reality assisted surgery: a urologic training tool

    Directory of Open Access Journals (Sweden)

    Ryan M Dickey

    2016-01-01

    Full Text Available Augmented reality is widely used in aeronautics and is a developing concept within surgery. In this pilot study, we developed an application for use on Google Glass ® optical head-mounted display to train urology residents in how to place an inflatable penile prosthesis. We use the phrase Augmented Reality Assisted Surgery to describe this novel application of augmented reality in the setting of surgery. The application demonstrates the steps of the surgical procedure of inflatable penile prosthesis placement. It also contains software that allows for detection of interest points using a camera feed from the optical head-mounted display to enable faculty to interact with residents during placement of the penile prosthesis. Urology trainees and faculty who volunteered to take part in the study were given time to experience the technology in the operative or perioperative setting and asked to complete a feedback survey. From 30 total participants using a 10-point scale, educational usefulness was rated 8.6, ease of navigation was rated 7.6, likelihood to use was rated 7.4, and distraction in operating room was rated 4.9. When stratified between trainees and faculty, trainees found the technology more educationally useful, and less distracting. Overall, 81% of the participants want this technology in their residency program, and 93% see this technology in the operating room in the future. Further development of this technology is warranted before full release, and further studies are necessary to better characterize the effectiveness of Augmented Reality Assisted Surgery in urologic surgical training.

  3. Augmented reality assisted surgery: a urologic training tool

    Science.gov (United States)

    Dickey, Ryan M; Srikishen, Neel; Lipshultz, Larry I; Spiess, Philippe E; Carrion, Rafael E; Hakky, Tariq S

    2016-01-01

    Augmented reality is widely used in aeronautics and is a developing concept within surgery. In this pilot study, we developed an application for use on Google Glass® optical head-mounted display to train urology residents in how to place an inflatable penile prosthesis. We use the phrase Augmented Reality Assisted Surgery to describe this novel application of augmented reality in the setting of surgery. The application demonstrates the steps of the surgical procedure of inflatable penile prosthesis placement. It also contains software that allows for detection of interest points using a camera feed from the optical head-mounted display to enable faculty to interact with residents during placement of the penile prosthesis. Urology trainees and faculty who volunteered to take part in the study were given time to experience the technology in the operative or perioperative setting and asked to complete a feedback survey. From 30 total participants using a 10-point scale, educational usefulness was rated 8.6, ease of navigation was rated 7.6, likelihood to use was rated 7.4, and distraction in operating room was rated 4.9. When stratified between trainees and faculty, trainees found the technology more educationally useful, and less distracting. Overall, 81% of the participants want this technology in their residency program, and 93% see this technology in the operating room in the future. Further development of this technology is warranted before full release, and further studies are necessary to better characterize the effectiveness of Augmented Reality Assisted Surgery in urologic surgical training. PMID:26620455

  4. Prevention of ventriculoperitoneal shunt complications after intraperitoneal urological surgeries.

    Science.gov (United States)

    Ikeda, Takashi; Akiyama, Sayaka; Kim, Woo Jin; Ito, Susumu; Yamazaki, Yuichiro

    2017-07-01

    To evaluate perioperative management for the prevention of postoperative shunt infection and malfunction after intraperitoneal urological surgery in patients with myelodysplasia and a ventriculoperitoneal shunt. From 2005 to 2015, 20 consecutive patients with myelodysplasia and a ventriculoperitoneal shunt who underwent intraperitoneal urological surgeries were managed with the same perioperative regimen. Intraperitoneal surgeries involved opening gastrointestinal tracts, including bladder augmentation by enterocystoplasty, creating continent catheterizable channels and Malone antegrade continent enema. We compared results with those from seven previous reports regarding postoperative shunt complications, surgical histories of previous shunt revisions, management of bacteriuria before surgery preoperative bowel preparation, antibiotic regimens, and duration of indwelling drain. Of 20 patients, 18 received prior shunt revisions, and 14 had positive urine culture before surgery that was managed with oral antibiotics. Thirteen patients underwent bladder augmentation with ileum, and one underwent augmentation with sigmoid colon. Nineteen patients underwent Malone antegrade continent enema using the appendix. All parenteral antibiotics were stopped on postoperative day 2.5. Mean duration of indwelling peritoneal drain was 2.7days. Mean follow-up period was 59.8months. Neither postoperative shunt infections nor intraperitoneal shunt malfunctions were recognized during follow-up period. This is the first study to evaluate postoperative ventriculoperitoneal shunt complications in patients with myelodysplasia who underwent intraperitoneal urological surgeries with a specific perioperative regimen. Shunt complications are greatly reduced by rigorous perioperative management, including preoperative control of bacteriuria, appropriate administration of prophylactic antibiotics, and early removal of intraperitoneal drains. The type of study: Case series with no comparison group

  5. Urological surgery in elderly patients: results and complications

    Directory of Open Access Journals (Sweden)

    Brodak M

    2015-02-01

    Full Text Available Milos Brodak, Jan Tomasek, Jaroslav Pacovsky, Lukas Holub, Petr Husek Department of Urology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic Purpose: Owing to the large aging population, a growing number of elderly patients are undergoing surgical treatment. Surgical procedures in elderly patients are associated with a higher risk of complications. The aim of this study was to evaluate the efficacy and safety of urological surgeries in old patients.Methods: The authors carried out a retrospective study, evaluating results and early postoperative complications in patients aged 75 years and older. The cohort of patients included 221 patients who underwent surgical procedures in the department of urology between January 2011 and December 2012. The average age of patients was 78. The results and complications were categorized based on the type of surgery performed, and the Dindo–Clavien scale.Results: The median follow-up was 18 months. All surgeries for malignant tumors were performed successfully with no residual disease. Totally, 48 (22% complications were recorded. The most serious were as follows: one patient (<0.5% died; and four (<2% patients underwent reoperation. The most common complications involved infection, mainly sepsis and surgical site infections. Other complications included mild respiratory insufficiency, delirium, bleeding, etc.Conclusion: Surgeries in elderly patients were effective and safe. The cornerstone of safety is careful preparation and treatment of comorbidities. Complications occurred mainly as a result of emergency procedures during emergency procedures and in major surgeries such as cystectomy and nephrectomy. The standard use of low molecular-weight heparin caused no incidence of thromboembolic disease. Keywords: urinary tract, aged, postoperative complications, Dindo–Clavien classification

  6. Economic impact of training and career decisions on urological surgery.

    Science.gov (United States)

    Langston, Joshua P; Kirby, E Will; Nielsen, Matthew E; Smith, Angela B; Woods, Michael E; Wallen, Eric M; Pruthi, Raj S

    2014-03-01

    Medical students and residents make career decisions at a relatively young age that have significant implications for their future income. While most of them attempt to estimate the impact of these decisions, there has been little effort to use economic principles to illustrate the impact of certain variables. The economic concept of net present value was paired with available Medical Group Management Association and Association of American Medical Colleges income data to calculate the value of career earnings based on variations in the choice of specialty, an academic vs a private practice career path and fellowship choices for urology and other medical fields. Across all specialties academic careers were associated with lower career earnings than private practice. However, among surgical specialties the lowest difference in value between these 2 paths was for urologists at only $334,898. Fellowship analysis showed that training in pediatric urology was costly in forgone attending salary and it also showed a lower future income than nonfellowship trained counterparts. An additional year of residency training (6 vs 5 years) caused a $201,500 decrease in the value of career earnings. Choice of specialty has a dramatic impact on future earnings, as does the decision to pursue a fellowship or choose private vs academic practice. Additional years of training and forgone wages have a tremendous impact on monetary outcomes. There is also no guarantee that fellowship training will translate into a more financially valuable career. The differential in income between private practice and academics was lowest for urologists. Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  7. mHealth in Urology: A Review of Experts' Involvement in App Development.

    Directory of Open Access Journals (Sweden)

    Nuno Pereira-Azevedo

    Full Text Available Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with the aim of assessing the level of participation of healthcare professionals (HCP and scientific Urology associations in their development.A systematic search was performed on PubMed, Apple's App Store and Google's Play Store, for Urology apps, available in English. Apps were reviewed by three graders to determine the app's platform, target customer, developer, app type, app category, price and the participation of a HCP or a scientific Urology association in the development.The search yielded 372 apps, of which 150 were specific for Urology. A fifth of all apps had no HCP involvement (20.7% and only a third had been developed with a scientific Urology association (34.7%. The lowest percentage of HCP (13.4% and urological association (1.9% involvement was in apps designed for the general population. Furthermore, there was no contribution from an Urology society in "Electronic Medical Record" nor in "Patient Information" apps. A limitation of the study is that only Android and iOS apps were reviewed.Despite the increasing Mobile Health (mHealth market, this is the first study that demonstrates the lack of expert participation in the design of Urology apps, particularly in apps designed for the general public. Until clear regulation is enforced, the urological community should help regulate app development. Maintaining a register of certified apps or issuing an official scientific seal of approval could improve overall app quality. We propose that urologists become stakeholders in mHealth, shaping future app design and promoting peer-review app validation.

  8. mHealth in Urology: A Review of Experts’ Involvement in App Development

    Science.gov (United States)

    Pereira-Azevedo, Nuno; Carrasquinho, Eduardo; Cardoso de Oliveira, Eduardo; Cavadas, Vitor; Osório, Luís; Fraga, Avelino; Castelo-Branco, Miguel; Roobol, Monique J.

    2015-01-01

    Introduction Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps) have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with the aim of assessing the level of participation of healthcare professionals (HCP) and scientific Urology associations in their development. Material and Methods A systematic search was performed on PubMed, Apple's App Store and Google's Play Store, for Urology apps, available in English. Apps were reviewed by three graders to determine the app’s platform, target customer, developer, app type, app category, price and the participation of a HCP or a scientific Urology association in the development. Results The search yielded 372 apps, of which 150 were specific for Urology. A fifth of all apps had no HCP involvement (20.7%) and only a third had been developed with a scientific Urology association (34.7%). The lowest percentage of HCP (13.4%) and urological association (1.9%) involvement was in apps designed for the general population. Furthermore, there was no contribution from an Urology society in "Electronic Medical Record" nor in "Patient Information" apps. A limitation of the study is that only Android and iOS apps were reviewed. Conclusions Despite the increasing Mobile Health (mHealth) market, this is the first study that demonstrates the lack of expert participation in the design of Urology apps, particularly in apps designed for the general public. Until clear regulation is enforced, the urological community should help regulate app development. Maintaining a register of certified apps or issuing an official scientific seal of approval could improve overall app quality. We propose that urologists become stakeholders in mHealth, shaping future app design and promoting peer-review app validation. PMID:25984916

  9. mHealth in Urology: A Review of Experts' Involvement in App Development.

    Science.gov (United States)

    Pereira-Azevedo, Nuno; Carrasquinho, Eduardo; Cardoso de Oliveira, Eduardo; Cavadas, Vitor; Osório, Luís; Fraga, Avelino; Castelo-Branco, Miguel; Roobol, Monique J

    2015-01-01

    Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps) have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with the aim of assessing the level of participation of healthcare professionals (HCP) and scientific Urology associations in their development. A systematic search was performed on PubMed, Apple's App Store and Google's Play Store, for Urology apps, available in English. Apps were reviewed by three graders to determine the app's platform, target customer, developer, app type, app category, price and the participation of a HCP or a scientific Urology association in the development. The search yielded 372 apps, of which 150 were specific for Urology. A fifth of all apps had no HCP involvement (20.7%) and only a third had been developed with a scientific Urology association (34.7%). The lowest percentage of HCP (13.4%) and urological association (1.9%) involvement was in apps designed for the general population. Furthermore, there was no contribution from an Urology society in "Electronic Medical Record" nor in "Patient Information" apps. A limitation of the study is that only Android and iOS apps were reviewed. Despite the increasing Mobile Health (mHealth) market, this is the first study that demonstrates the lack of expert participation in the design of Urology apps, particularly in apps designed for the general public. Until clear regulation is enforced, the urological community should help regulate app development. Maintaining a register of certified apps or issuing an official scientific seal of approval could improve overall app quality. We propose that urologists become stakeholders in mHealth, shaping future app design and promoting peer-review app validation.

  10. Technical Note: Using DEG CPCs at upper tropospheric temperatures

    CERN Document Server

    Wimmer, D; Nieminen, T; Duplissy, J; Ehrhart, S; Almeida, J; Rondo, L; Franchin, A; Kreissl, F; Manninen, H E; Kulmala, M; Curtius, J; Petäjä, T

    2014-01-01

    Over the last few years, several Condensation Particle Counters (CPC) capable of measuring in the sub-3 nm size range have been developed. Here we study the performance of Diethylene glycol (DEG) based CPCs at different temperatures during Cosmics Leaving Outdoor Droplets (CLOUD) measurements at CERN. The data shown here is the first set of verification measurements for sub-3 nm CPCs under upper tropospheric temperatures using atmospherically relevant aerosol particles. To put the results in perspective we calibrated the DEG-CPC at room temperature, resulting in a cut-off diameter of 1.4 nm. All diameters refer to mobility equivalent diameters in this manuscript. At upper tropospheric temperatures between −25 °C and −65 °C, we found cut-off sizes in the range of 2.5 and 2.8 nm. Due to low number concentration after size classification, the cut-off diameters have a high uncertainty (±0.3 nm) associated with them. Operating two laminar flow DEG CPCs with different cut-off sizes together with other aeroso...

  11. Cyanoacrylic tissue glues: Biochemical properties and their usage in urology

    Science.gov (United States)

    Ayyıldız, Sema Nur; Ayyıldız, Ali

    2017-01-01

    Tissue adhesives are being used in medical and cosmetic industries and first aid for a long time. But their everyday usage has not been widespread. Only case report information is available about their usage. Despite good and meaningful results after they were used, there is lack of standard information that gives idea of about in which cases they could be helpful. Nowadays, cyanoacrylates are used in the surgery more frequently. In this review, we wanted to oversee the biochemical properties and the urological utilisation areas of cyanoacrylates. PMID:28270946

  12. Urological outcome after myelomeningocele: 20 years of follow-up

    DEFF Research Database (Denmark)

    Thorup, Jørgen Mogens; Biering-Sorensen, Fin; Cortes, Dina

    2011-01-01

    Study Type - Therapy (case series)¿Level of Evidence 4 OBJECTIVES: To evaluate the urological outcome in a long-term follow-up of individuals with myelomeningocele and relate the findings obtained to urodynamic variables in childhood. MATERIAL AND METHODS: Individuals with myelomeningocele born....... In childhood and at follow-up, kidney function was estimated with renography and isotope-glomerular filtration rate examinations. RESULTS: In total, 52 individuals (28 boys and 24 girls) aged 19-41 years (median, 29 years) had follow-up. Of these, 37 (71%) individuals had bilateral normal kidney function...

  13. Interventional urology: endourology in small animal veterinary medicine.

    Science.gov (United States)

    Berent, Allyson C

    2015-07-01

    The use of novel image-guided techniques in veterinary medicine has become more widespread, especially in urologic diseases. With the common incidence of urinary tract obstructions, stones disease, renal disease, and urothelial malignancies, combined with the recognized invasiveness and morbidity associated with traditional surgical techniques, the use of minimally invasive alternatives using interventional radiology and interventional endoscopy techniques has become incredibly appealing to owners and clinicians. This article provides a brief overview of some of the most common procedures done in endourology in veterinary medicine to date, providing as much evidence-based medicine as possible when comparing with traditional surgical alternatives.

  14. Ethics and contemporary urology practice: Setting out principles

    Directory of Open Access Journals (Sweden)

    A Mohan

    2009-01-01

    Full Text Available Several situations of great ethical implications are encountered by physicians in daily urological practice. Informed consent for interventions, selection of patients for operative demonstrations and educational workshops, enrollment of patients in clinical trials, and the use of technology are some issues that call for stringent application of ethical principles in decision making. The issues of autonomy, privacy, rights, duties, and privileges that arise have to pass the tests prescribed by contemporary social mores and regulations. Some of the issues encountered, principles applicable, and covenants and documents that guide decision making are discussed.

  15. Urologic applications of multiplanar and three-dimensional computed tomography.

    Science.gov (United States)

    Olson, M C; Posniak, H V

    1995-01-01

    The introduction of helical computed tomography (CT) has resulted in improved quality of multiplanar reformations and three-dimensional reconstructions in the chest and abdomen and has made CT angiography a clinical reality. These imaging techniques are useful for evaluating the urinary tract, adding a new dimension to its display, resulting in improved diagnosis of renal and perirenal disease. This article reviews the indications and techniques utilized for multiplanar and three-dimensional CT for urology. The advantages and limitations are discussed, and normal and pathologic findings in the urinary tract illustrated.

  16. Multimedia search system for a textbook of urology in Japanese.

    Science.gov (United States)

    Okada, Y; Yamashita, Y; Takahashi, T

    1995-01-01

    A search system for the textbook of urology has been developed and evaluated. The textbook is written in Japanese with 1.4 megabytes of text and has about 1000 pictures. The contents of the textbook can be seen with English or Japanese medical terms. The system contains a dictionary of Japanese medical terms. The dictionary has a network structure based on Japanese ideographic characters. Such a search system is useful for physicians because of its speed and the widely spread medical knowledge of many authors of the textbook.

  17. Book review. La forma degli animali. Adolf Portmann

    Directory of Open Access Journals (Sweden)

    Manuel Graziani

    2013-09-01

    Full Text Available Nel 1931 il biologo Adolf Portmann era già talmente noto a livello internazionale per le sue ricerche da guadagnarsi la cattedra in zoologia nell'università della sua città natale, Basilea, all'età di appena 34 anni. All'attività di docente universitario ha sempre affiancato un'originale riflessione sul significato delle scienze della vita, imponendosi come una delle figure chiave nel dibattito tra biologia teoretica, estetica e antropologia filosofica. La forma degli animali, la sua opera più celebre, si pone al confine tra varie discipline e conserva un grande interesse ancora oggi che il dialogo tra estetica e biologia si è fatto nuovamente intenso. Pubblicata nel 1948 e in forma ampliata nel 1960 (da cui deriva questa prima edizione italiana a cura di Pietro Conte l'opera rappresenta il frutto più maturo delle sue ricerche "interdisciplinari".Un saggio che nasce dall'insoddisfazione nei confronti dei paradigmi scientifici consolidati e che ripropone l'idea morfologica in biologia sulla scorta del pensiero di J. W. Goethe il quale affermava che "tutto ciò che è deve anche dar cenno di sé e mostrarsi". Adolf Portmann è un convinto sostenitore che dalla forma si possano dedurne le complessive caratteristiche interne ed esterne degli animali. Secondo questa prospettiva la peculiare fisionomia dell'organismo dipende dalla congiunzione delle sue parti e dalle loro reciproche funzioni. Tuttavia l'autore non vede nello studio della forma l'alternativa al funzionalismo quanto, piuttosto, il suo necessario bilanciamento come dichiara nell'introduzione: "… per giungere alla conoscenza della vita animale di strade ce ne sono molte, e tutte possono contribuire ad arricchire la nostra esperienza. Questo lavoro si occupa della forma degli animali e si propone di mettere in luce la peculiare natura dell'aspetto visibile. Ci sono persone che si dedicano allo studio degli animali, conoscono moltissime specie, hanno imparato centinaia di nomi e

  18. Geology of the Delta, Escalante, Price, Richfield and Salina 1 deg x 2 deg NTMS quadrangles, Utah

    Science.gov (United States)

    Thayer, P. A.

    1981-11-01

    The National Uranium Resource Evaluation (NURE) program was established to evaluate domestic uranium resources in the continental United States and to identify areas favorable for uranium exploration. The Grand Junction Office of the Department of Energy is responsible for administering the program. The Savannah River Laboratory (SRL) is responsible for hydrogeochemical and stream-sediment reconnaissance (HSSR) of 3.9 million sq km (1,500,000 mi(2)) in 37 eastern and western states. This document provides geologic and mineral resources reports for the Delta, Escalante, Price, Richfield, and Salina 1 deg x 2 deg National Topographic Map Series quadrangles, Utah. The purpose of these reports is to provide background geologic and mineral resources information to aid in the interpretation of NURE geochemical reconnaissance data. Except for the Escalante Quadrangle, each report is accompanied by a geologic map and a mineral locality map (Plates 1-8, in pocket).

  19. [Appropriateness of indicating aortocoronary bypass and coronary angioplasty: results of an observational prospective study in the Lombardy region. Gruppo Interdisciplinare Valutazione Appropriatezza Rivascolarizzazione Coronarica].

    Science.gov (United States)

    Valagussa, F; Maggioni, A P; Valagussa, L; Filardo, G; Mura, G; Liberati, A

    1997-12-01

    Most studies on the appropriateness of cardiac revascularization procedures have been aimed at detecting "overuse" (ie when patients get a procedure without a clear indication), while little attention has been paid yet to "underuse" (when patients who could benefit from a procedure do not get it). This study was planned to assess the extent of over- and underuse of revascularization procedures in northern Italy. A multidisciplinary panel of experts convened by the Italian Association of Hospital Cardiologists (ANMCO) rated the appropriateness of 898 "theoretical indications" for coronary artery by-pass grafting (CABG) and percutaneous transluminal angioplasty (PTCA) using the RAND Corporation methodology. Standardized information has been collected on a consecutive sample of patients in the Lombardy region and identified during performance of a coronary angiogram at one of the services belonging to the GISE (Gruppo Italiano Studi Emodinamica) network. Out of the 2718 consecutive patients undergoing a coronary angiogram during the recruitment period (February-May 1995), a total of 1821 (70%) were eligible for the appropriateness study. Indication for CABG were appropriate in 565 (80%) patients, uncertain in 111 (16%) and inappropriate in 25 (4%). Corresponding values for PTCA were: 40% (n = 262), 46% (n = 300) and 14% (n = 90). Among the 394 to whom a medical therapy was recommended after angiography, the indication was considered appropriated in only 14% (n = 57) and uncertain for 30% (n = 117). For the remaining 220, the indication was considered inappropriate, suggesting that according to the panel criteria, 56% of the patients should have received a revascularization procedure (either a CABG or PTCA) instead. These results suggest that underuse of revascularization procedures represents a substantial health care problem in Lombardy region, at least with reference to the period covered by this study. The study in itself does not make it possible to understand

  20. Robotic Urological Surgery%机器人泌尿外科手术

    Institute of Scientific and Technical Information of China (English)

    吴志辉; 莱锦洪

    2008-01-01

    @@ 1 Introduction In past few decades, better understandings of anatomy and advance in techniques and technology have revolutionized urological surgery. Laparoscopic surgery has now become one of the basic instruments of urologists. Laparoscopic radical nephrectomy is currently the standard of care in most urological centers.

  1. mHealth in urology : A review of experts' involvement in app development

    NARCIS (Netherlands)

    Pereira-Azevedo, N. (Nuno); Carrasquinho, E. (Eduardo); De Oliveira, E.C. (Eduardo Cardoso); Cavadas, V. (Vitor); Osório, L. (Luís); Fraga, A. (Avelino); Castelo-Branco, M. (Miguel); Roobol, M.J. (Monique J.)

    2015-01-01

    textabstractIntroduction: Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps) have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with

  2. Program for laparoscopic urological skills assessment: setting certification standards for residents

    NARCIS (Netherlands)

    Tjiam, I.M.; Schout, B.M.; Hendrikx, A.J.M.; Muijtjens, A.M.M.; Scherpbier, A.J.J.A.; Witjes, J.A.; Vleuten, C.P.M. van der

    2013-01-01

    AIM: There is growing pressure from the government and the public to define proficiency standards for surgical skills. Aim of this study was to estimate the reliability of the Program for Laparoscopic Urological Skills (PLUS) assessment and to set a certification standard for second-year urological

  3. [Establishment of university departments of urology in North Rhine-Westphalia: the Aachen model].

    Science.gov (United States)

    Moll, F H; Halling, T; Rathert, P; Krischel, M; Fangerau, H

    2014-09-01

    The foundation of university departments of urology in postwar East and West Germany faced some opposition by some university professors of surgery who wanted to preserve the unity of their discipline. In North Rhine-Westphalia, heads of municipal hospitals or senior members of university hospitals' staff often received the first chaired professorships of urology.

  4. mHealth in urology : A review of experts' involvement in app development

    NARCIS (Netherlands)

    Pereira-Azevedo, N. (Nuno); Carrasquinho, E. (Eduardo); De Oliveira, E.C. (Eduardo Cardoso); Cavadas, V. (Vitor); Osório, L. (Luís); Fraga, A. (Avelino); Castelo-Branco, M. (Miguel); Roobol, M.J. (Monique J.)

    2015-01-01

    textabstractIntroduction: Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps) have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with

  5. A prospective audit of emergency urology activity in a university teaching hospital

    LENUS (Irish Health Repository)

    2014-06-01

    Urology cover is commonly available out-of-hours in most teaching hospitals. However, increased pressure to reduce hospital expenditure has forced many institutions to consider removing middle grade cover outside of normal working hours. The aim of this study was to audit the emergency urology activity in our institution over a 12-month period.

  6. Influence of social networks on congresses of urological societies and associations: Results of the 81th National Congress of the Spanish Urological Association.

    Science.gov (United States)

    Gómez-Rivas, J; Rodríguez-Socarrás, M E; Tortolero-Blanco, L; Garcia-Sanz, M; Alvarez-Maestro, M; Ribal, M J; Cózar-Olmo, M

    2017-04-01

    To measure social network activity during the 81th National Congress of the Spanish Urological Association (AEU) and to compare it with the activity during other congresses of national and international urological associations. We designed and registered the official hashtag #AEU16 for the 81(th) National Congress of the AEU on the Symplur website. The following measurements were recorded: number of participants, number of tweets, tweets by participant, tweets per hour and views. The number of participants in the social network activity during the congress was 207. The measurements of activity in Twitter consisted of a total of 1866 tweets, a mean rate of 16 tweets/h, 9 tweets per participant and 1,511,142 views. The activity during the international congresses is as follows: 2016 American Urological Association annual congress (views: 28,052,558), 2016 European Association of Urology annual congress (views: 13,915,994), 2016 Urological Society of Australia and New Zealand (views: 4,757,453), 2015 Société Internationale d'Urologie annual congress (views: 1,023,038). The activity during the national congresses was recorded as follows: 2016 Annual Conference of The British Association of Urological Surgeons (views: 2,518,880), 81th National Congress of the AEU (views: 1,511,142), 109th Congress of l'Association Française d'Urologie (views: 662,828), 67th German Congress of Urology (views: 167,347). We found 10 posts in Facebook and 2 communications via Periscope TV related to #AEU16. The social network activity during the 81(th) National Congress of the AEU was notable given the results of this study. The use of social networks has expanded among urological associations, congresses and meetings, giving them a global character. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  7. Artificial neural networks for decision-making in urologic oncology.

    Science.gov (United States)

    Anagnostou, Theodore; Remzi, Mesut; Lykourinas, Michael; Djavan, Bob

    2003-06-01

    The authors are presenting a thorough introduction in Artificial Neural Networks (ANNs) and their contribution to modern Urologic Oncology. The article covers a description of Artificial Neural Network methodology and points out the differences of Artificial Intelligence to traditional statistic models in terms of serving patients and clinicians, in a different way than current statistical analysis. Since Artificial Intelligence is not yet fully understood by many practicing clinicians, the authors have reviewed a careful selection of articles in order to explore the clinical benefit of Artificial Intelligence applications in modern Urology questions and decision-making. The data are from real patients and reflect attempts to achieve more accurate diagnosis and prognosis, especially in prostate cancer that stands as a good example of difficult decision-making in everyday practice. Experience from current use of Artificial Intelligence is also being discussed, and the authors address future developments as well as potential problems such as medical record quality, precautions in using ANNs or resistance to system use, in an attempt to point out future demands and the need for common standards. The authors conclude that both methods should continue to be used in a complementary manner. ANNs still do not prove always better as to replace standard statistical analysis as the method of choice in interpreting medical data.

  8. Impact of sarcopenia in the management of urological cancer patients.

    Science.gov (United States)

    Fukushima, Hiroshi; Koga, Fumitaka

    2017-05-01

    Sarcopenia, the degenerative and systemic loss of skeletal muscle mass, develops as a consequence of the progression of cancer cachexia. Recent studies suggest that sarcopenia may be used as a biomarker in the management of patients with several cancers. Areas covered: In this article, the authors review 1) the methods to simply and optimally evaluate and define sarcopenia using computed tomography images in daily clinical practice and 2) the impact of sarcopenia in the management of urological cancers, specifically focusing on the usefulness in predicting treatment-related complications and prognosis. The authors also discuss the prognostic importance of changes in skeletal muscle mass in the course of treatment and the potential roles of nutritional support and exercise to prevent progression of sarcopenia. Expert commentary: Sarcopenia is associated with treatment-related complications and unfavorable prognosis in urological cancer patients. Nutritional support and exercise might be helpful in improving sarcopenia. The impact of these interventions on clinical outcomes would be elucidated by ongoing or future clinical studies.

  9. [Urologic emergencies: our difficult experience with care services].

    Science.gov (United States)

    Belvis Esclapes, V M; Merenciano Cortina, F; Torrus Tendero, P; Mira Llinares, A

    1994-09-01

    Urological emergencies, except those occurring in children, seen in a General Hospital were studied for one year. The retrospective study, both descriptive and comparative, conducted has allowed to know that there had been 3,244 emergencies (4.2% of total cases) though the urologist acted only in 1,410 (43.4%). A predominance of males (76.10%) in their sixth and seventh decade (33% of total) was seen. Presentation increased slightly (2%) above average during the summer months. 80.9% came to the Emergency Ward of their own accord and 70% were discharged soon after assistance. Nephritic colic (19.08%), haematuria (14.04%) and U.T.I. (13.83%) were the most common causes for presentation. A total of 284 patients (20.14%) required hospitalization. 96.6% were given medical and/or instrumental treatment, versus 3.4% (49) who underwent surgery basically due to testicular disease (34.69%), sepsis (24.50%), traumatic injury of male genitalia (20.3%), etc. The most frequent conditions were analyzed by age, sex, and seasonal distribution. Also, an analysis was made on the concept of "Urological Emergency" to evaluate incidence and types in our environment.

  10. Training and outcome monitoring in robotic urologic surgery.

    Science.gov (United States)

    Liberman, Daniel; Trinh, Quoc-Dien; Jeldres, Claudio; Valiquette, Luc; Zorn, Kevin C

    2011-11-08

    The use of robot-assisted laparoscopic technology is rapidly expanding, with applicability in numerous disciplines of surgery. Training to perform robot-assisted laparoscopic urological procedures requires a motivated learner, a motivated teacher or proctor, a curriculum with stepwise learning objectives, and regular access to a training robot. In light of the many constraints that limit surgical training, animal models should be utilized to quantifiably improve the surgical skills of residents and surgical fellows, before these skills are put into practice on patients. A system based on appropriate supervision, graduated responsibility, real-time feedback, and objective measure of progress has proven to be safe and effective. Surgical team education directed towards cohesion is perhaps the most important aspect of training. At present, there are very few published guidelines for the safe introduction of robotic urologic surgery at an institution. Increasing evidence demonstrates the effects of learning curve and surgical volume on oncological and functional outcomes in robotic surgery (RS). This necessitates the introduction of mechanisms and guidelines by which trainee surgeons can attain a sufficient level of skill, without compromising the safety of patients. Guidelines for outcome monitoring following RS should be developed, to ensure patient safety and sufficient baseline surgeon skill.

  11. Clinical Application of Percutaneous Nephrostomy in Some Urologic Diseases

    Institute of Scientific and Technical Information of China (English)

    Hongbo LUO; Xiuheng LIU; Tianpeng WU; Xiaobin ZHANG

    2008-01-01

    Percutaneous nephrostomy was applied in some other urologic diseases and the efficacy was evaluated. Percutaneous nephrostomy for percutaneous nephrolithotomy (PNL) was performed in patients with various renal, perinephric and bladder diseases (n=79). The tract establishment, operation duration and complications were observed and the efficacy was assessed. The results showed that the tracts were successfully established in 79 cases. The operation lasted 4-20 min. 12F-16F single tract was established in nephrohydrop patients and 16F-20F single or multiple tracts were established in patients with pyonephrosis, renal cortical abscess, renal cyst and perinephric abscess. During dilation, no leakage of liquor puris was noted. Establishment of 18F single tract was achieved in one urinoma patient. In two patients with foreign body in kidney, the foreign bodies were removed via established 14F single tract. 18F tracts were established in 2 patients with bladder contracture, which was followed by the placement of 16F balloon urethral catheter for drainage. No complications, such as massive bleeding, intestinal injury and spreading of infection took place in our series. All the patients were followed up for 2-12 months. No long-term complications such as dropping of drainage tube occurred. It is concluded that as a minimally invasive technique, percutaneous nephrostomy has the advantages of convenience, simplicity and causing less complications and can be used for various urologic diseases.

  12. The value of a core clinical rotation in urology for medical students.

    Science.gov (United States)

    Patel, Premal; Nayak, Jasmir G; McGregor, Thomas B

    2015-01-01

    In 2013, our institution underwent a change to the undergraduate medical curriculum whereby a clinical urology rotation became mandatory. In this paper, we evaluated the perceived utility and value of this change in the core curriculum. Third year medical students, required to complete a mandatory 1-week clinical urology rotation, were asked to complete a survey before and after their rotation. Fourth year medical students, not required to complete this rotation, were also asked to complete a questionnaire. Chi-squared and Fisher's exact test were used for data analysis. In total, 108 third year students rotated through urology during the study period. Of these, 66 (61%) completed the pre-rotation survey and 54 (50%) completed the post-rotation survey. In total, there were 110 fourth year students. Of these, 44 (40%) completed the questionnaire. After completing their mandatory rotations, students felt more comfortable managing and investigating common urological problems, such as hematuria and renal colic. Students felt they had a better understanding of how to insert a Foley catheter and felt comfortable independently inserting a Foley catheter. Importantly, students felt they knew when to consult urology and were also more likely to consider a career in urology. Compared to fourth year students, third year students felt urology was an important component to a family medicine practice and felt they had a better understanding of when to consult urology. The introduction of a mandatory urology rotation for undergraduate medical students leads to a perceived improvement in fundamental urological knowledge and skill set of rotating students. This mandatory rotation provides a valuable experience that validates its inclusion.

  13. Survey on the perception of urology as a specialty by medical students

    Science.gov (United States)

    Kim, Soojin; Farrokhyar, Forough; Braga, Luis H.

    2016-01-01

    Introduction: Upon inquiring with medical students and urologists across Canada, it is evident that urology is perceived as a male-dominant specialty, among other stereotypes. These misperceptions may hamper the recruitment of the best and brightest trainees. With that in mind, we surveyed medical students at our institution to obtain an objective assessment of their perception of urology and to determine the cause for misperceptions. Methods: A 25-factor, validated, anonymous, cross-sectional, self-reported, electronic survey was sent to all medical students at McMaster University to assess their perception of urology. The survey was piloted among students and educational leaders to optimize face and content validity, and minimize measurement bias. Six variables (years in training, role model, a family member or friend in urology, gender, and exposure) were selected a priori and entered into a logistic regression model to determine factors associated with a positive impression of the specialty. Results: The overall response rate was 70%. Of the respondents, 66% had no exposure to urology and 61% found the amount of exposure to be inadequate. Urology staff and resident involvement in education was considered to be poor by over 30% of medical students. Over 70% perceived urology to be a specialty with a great gender imbalance. On multivariate analysis, exposure to urology was the most important factor (purology exposure and poor staff and resident involvement in undergraduate education were seen as potential causes for misperceptions of the specialty. Increasing exposure to urology, encouraging female students, constant effort to approach senior students, and providing mentorship are found to be important factors in establishing a positive perception of urology PMID:27800058

  14. Technical Note: Using DEG-CPCs at upper tropospheric temperatures

    Science.gov (United States)

    Wimmer, D.; Lehtipalo, K.; Nieminen, T.; Duplissy, J.; Ehrhart, S.; Almeida, J.; Rondo, L.; Franchin, A.; Kreissl, F.; Bianchi, F.; Manninen, H. E.; Kulmala, M.; Curtius, J.; Petäjä, T.

    2015-07-01

    Over the last few years, several condensation particle counters (CPCs) capable of measuring in the sub-3 nm size range have been developed. Here we study the performance of CPCs based on diethylene glycol (DEG) at different temperatures during Cosmics Leaving OUtdoor Droplets (CLOUD) measurements at CERN. The data shown here are the first set of verification measurements for sub-3 nm CPCs under upper tropospheric temperatures using atmospherically relevant aerosol particles. To put the results in perspective we calibrated the DEG-CPC at room temperature, resulting in a cut-off diameter of 1.4 nm. All diameters refer to mobility equivalent diameters in this paper. At upper tropospheric temperatures ranging from 246.15 K to 207.15 K, we found cut-off sizes relative to a particle size magnifier in the range of 2.5 to 2.8 nm. Due to low number concentration after size classification, the cut-off diameters have a high uncertainty (±0.3 nm) associated with them. Operating two laminar flow DEG-CPCs with different cut-off sizes together with other aerosol instruments, we looked at the growth rates of aerosol population in the CLOUD chamber for particles smaller than 10 nm at different temperatures. A more consistent picture emerged when we normalized the growth rates to a fixed gas-phase sulfuric acid concentration. All of the instruments detected larger growth rates at lower temperatures, and the observed growth rates decreased as a function of temperature, showing a similar trend for all instruments. The theoretical calculations had a similar but much smaller temperature dependency.

  15. Prevalence of Staphylococcus aureus and of methicillin-resistant S. aureus clonal complexes in bulk tank milk from dairy cattle herds in Lombardy Region (Northern Italy).

    Science.gov (United States)

    Cortimiglia, C; Luini, M; Bianchini, V; Marzagalli, L; Vezzoli, F; Avisani, D; Bertoletti, M; Ianzano, A; Franco, A; Battisti, A

    2016-10-01

    Staphylococcus aureus is the most important causative agent of subclinical mastitis in cattle resulting in reduced milk production and quality. Methicillin-resistant S. aureus (MRSA) strains has a clear zoonotic relevance, especially in the case of occupational exposure. The aim of the study was to evaluate the prevalence of S. aureus and MRSA in bulk tank milk (BTM) from dairy cattle herds in the Lombardy Region (Northern Italy) and to identify the main MRSA circulating genotypes. MRSA strains were characterized by susceptibility testing, multi-locus sequence typing (MLST), spa typing and SCCmec typing. A total 844 BTM samples were analysed and S. aureus and MRSA were detected in 47·2% and 3·8% of dairy herds, respectively. MLST showed that the majority (28/32) of isolates belonged to the typical livestock-associated lineages: ST398, ST97 and ST1. Interestingly, in this study we report for the first time the new ST3211, a single locus variant of ST(CC)22, with the newly described 462 aroE allele. Our study indicates high diffusion of S. aureus mastitis and low, but not negligible, prevalence of MRSA in the considered area, suggesting the need for planning specific control programmes for bovine mastitis caused by S. aureus, especially when MRSA is implicated.

  16. Surveillance of acute infectious gastroenteritis (1992-2009) and food-borne disease outbreaks (1996-2009) in Italy, with a focus on the Piedmont and Lombardy regions.

    Science.gov (United States)

    Mughini-Gras, L; Graziani, C; Biorci, F; Pavan, A; Magliola, R; Ricci, A; Gilli, G; Carraro, E; Busani, L

    2012-02-23

    We describe trends in the occurrence of acute infectious gastroenteritis (1992 to 2009) and food-borne disease outbreaks (1996 to 2009) in Italy. In 2002, the Piedmont region implemented a surveillance system for early detection and control of food-borne disease outbreaks; in 2004, the Lombardy region implemented a system for surveillance of all notifiable human infectious diseases. Both systems are internet based. We compared the regional figures with the national mean using official notification data provided by the National Infectious Diseases Notification System (SIMI) and the National Institute of Statistics (ISTAT), in order to provide additional information about the epidemiology of these diseases in Italy. When compared with the national mean, data from the two regional systems showed a significant increase in notification rates of non-typhoid salmonellosis and infectious diarrhea other than non-typhoid salmonellosis, but for foodborne disease outbreaks, the increase was not statistically significant. Although the two regional systems have different objectives and structures, they showed improved sensitivity regarding notification of cases of acute infectious gastroenteritis and, to a lesser extent, food-borne disease outbreaks, and thus provide a more complete picture of the epidemiology of these diseases in Italy.

  17. Mutations suppressing the loss of DegQ function in Bacillus subtilis (natto) poly-γ-glutamate synthesis.

    Science.gov (United States)

    Do, Thi-Huyen; Suzuki, Yuki; Abe, Naoki; Kaneko, Jun; Itoh, Yoshifumi; Kimura, Keitarou

    2011-12-01

    The degQ gene of Bacillus subtilis (natto), encoding a small peptide of 46 amino acids, is essential for the synthesis of extracellular poly-gamma-glutamate (γPGA). To elucidate the role of DegQ in γPGA synthesis, we knocked out the degQ gene in Bacillus subtilis (natto) and screened for suppressor mutations that restored γPGA synthesis in the absence of DegQ. Suppressor mutations were found in degS, the receptor kinase gene of the DegS-DegU two-component system. Recombinant DegS-His(6) mutant proteins were expressed in Escherichia coli cells and subjected to an in vitro phosphorylation assay. Compared with the wild type, mutant DegS-His(6) proteins showed higher levels of autophosphorylation (R208Q, M195I, L248F, and D250N), reduced autodephosphorylation (D250N), reduced phosphatase activity toward DegU, or a reduced ability to stimulate the autodephosphorylation activity of DegU (R208Q, D249G, M195I, L248F, and D250N) and stabilized DegU in the phosphorylated form. These mutant DegS proteins mimic the effect of DegQ on wild-type DegSU in vitro. Interestingly, DegQ stabilizes phosphorylated DegS only in the presence of DegU, indicating a complex interaction of these three proteins.

  18. Mutations Suppressing the Loss of DegQ Function in Bacillus subtilis (natto) Poly-γ-Glutamate Synthesis ▿ †

    Science.gov (United States)

    Do, Thi-Huyen; Suzuki, Yuki; Abe, Naoki; Kaneko, Jun; Itoh, Yoshifumi; Kimura, Keitarou

    2011-01-01

    The degQ gene of Bacillus subtilis (natto), encoding a small peptide of 46 amino acids, is essential for the synthesis of extracellular poly-gamma-glutamate (γPGA). To elucidate the role of DegQ in γPGA synthesis, we knocked out the degQ gene in Bacillus subtilis (natto) and screened for suppressor mutations that restored γPGA synthesis in the absence of DegQ. Suppressor mutations were found in degS, the receptor kinase gene of the DegS-DegU two-component system. Recombinant DegS-His6 mutant proteins were expressed in Escherichia coli cells and subjected to an in vitro phosphorylation assay. Compared with the wild type, mutant DegS-His6 proteins showed higher levels of autophosphorylation (R208Q, M195I, L248F, and D250N), reduced autodephosphorylation (D250N), reduced phosphatase activity toward DegU, or a reduced ability to stimulate the autodephosphorylation activity of DegU (R208Q, D249G, M195I, L248F, and D250N) and stabilized DegU in the phosphorylated form. These mutant DegS proteins mimic the effect of DegQ on wild-type DegSU in vitro. Interestingly, DegQ stabilizes phosphorylated DegS only in the presence of DegU, indicating a complex interaction of these three proteins. PMID:21965392

  19. The Codice digitale degli archivi veronesi. A research instrument

    Directory of Open Access Journals (Sweden)

    Andrea Brugnoli

    2014-04-01

    Full Text Available The Codice digitale degli archivi veronesi (Verona’s archives digital code ‹http://cdavr.dtesis.univr.it› makes available online the digital reproductions of the documents produced by corporate bodies and family of Verona between the eighth and twelfth century. The framework of the site reflects the current organisation of the archives. A brief description of the circumstances around the creation of each archive, the corporate body or individual responsible for it and its structure is provided. Each archival unit is identified by its key elements: chronological date, name and qualification of the notary, original/copy, main editions.

  20. The Codice digitale degli archivi veronesi. A research instrument

    Directory of Open Access Journals (Sweden)

    Andrea Brugnoli

    2014-04-01

    Full Text Available The Codice digitale degli archivi veronesi (Verona’s archives digital code ‹http://cdavr.dtesis.univr.it› makes available online the digital reproductions of the documents produced by corporate bodies and family of Verona between the eighth and twelfth century. The framework of the site reflects the current organisation of the archives. A brief description of the circumstances around the creation of each archive, the corporate body or individual responsible for it and its structure is provided. Each archival unit is identified by its key elements: chronological date, name and qualification of the notary, original/copy, main editions.

  1. Islam, rappresentanza degli interessi religiosi e diritto comune europeo *

    Directory of Open Access Journals (Sweden)

    Gianfranco Macrì

    2011-03-01

    Full Text Available Contributo destinato alla pubblicazione negli Atti del Convegno: Europa e Islam. Ridiscutere i fondamenti per la disciplina delle libertà religiose, svoltosi a Salerno il 3 dicembre 2007.SOMMARIO: Premessa - 1. La società «reticolare» europea: sistema di governance e valori unificanti - 2. Europa e fenomeno religioso - 3. La sostanza del Trattato di Lisbona e il ruolo delle organizzazioni religiose - 4. Il dibattito interno all’Islam europeo - 5. La Carta dei musulmani d’Europa - 6. La rappresentanza degli interessi religiosi dell’Islam in Europa - Conclusioni.

  2. Perceived Role of Social Media in Urologic Knowledge Acquisition Among Young Urologists: A European Survey.

    Science.gov (United States)

    Rivas, Juan Gomez; Socarras, Moises Rodriguez; Patruno, Giulio; Uvin, Pieter; Esperto, Francesco; Dinis, Paulo Jorge; Roupret, Morgan; Borgmann, Hendrik

    2017-07-27

    Social media (SoMe) are increasingly being integrated into personal and professional life, with urology being a leading medical specialty in SoMe adoption. We aimed to assess the perceived role of SoMe in urologic knowledge acquisition among young urologists across Europe. Members of the European Society of Residents in Urology designed a 20-item online survey via surveymonkey.com. The survey was designed in accordance with Checklist for Reporting Results of Internet E-Surveys (CHERRIES) guidelines and was distributed via e-mail and social media in 23 European countries to urology residents and young urologists. Statistical Package for the Social Sciences (SPSS) software was used for descriptive statistics and statistical analysis. For comparative analysis the Mann-Whitney U test was used. A total of 316 young urologists with a mean age of 31.2±3.9 yr responded to the survey. Of the respondents, 99% use SoMe in a personal and/or professional way. YouTube and LinkedIn are the most frequently used platforms for professional use. SoMe were ranked in third place as an information source for urologic news/updates, lying behind journals and websites but ahead of congresses and books. Video content from YouTube or other sources was ranked as a preferred tool to see/understand surgical techniques ahead of websites and reference books. 61% follow urologic associations, 47% follow urologic events, 44% follow urologic journals, and 39% follow urologic experts on SoMe. The perceived influence of SoMe on urology knowledge was rated as moderate to high by 63% and as low to none by 37% of young urologists. Of the respondents, 44% apply guidelines on the appropriate use of SoMe in urology. SoMe play a significant role in knowledge acquisition by young urologists in Europe. Physicians, organizations, and institutions should strive to spread and provide valuable educational content through SoMe. Social media can be valuable for education in urology because it is useful to keep

  3. Zoogeografia storica e attuale dei carnivori e degli ungulati italiani

    Directory of Open Access Journals (Sweden)

    Marco Masseti

    2003-10-01

    Full Text Available Come per la maggior parte degli altri paesi europei, anche l'attuale composizione delle specie a mammiferi italiane si prefigura in gran parte come il risultato della plurima e prolungata azione antropica condotta sull'ambiente naturale. Questa, avviatasi alcuni millenni or sono, condiziona oggi più che mai la ridefinizione degli equilibri ecologici del nostro Paese. All'interno dell'attuale teriofauna terrestre italiana viene segnalata la presenza di 18 specie di carnivori e di 9 artiodattili, che può rivelarsi in alcuni casi come il risultato di acclimatazioni e/o naturalizzazioni di specie esotiche avvenute in cronologie diverse, anche di epoca molto recente. All'interno dei confini biogeografici dell'Italia andrebbero anche annoverate quelle popolazioni del cervo pomellato medio-orientale, Axis axis (Erxleben, 1777, che sono state naturalizzate in epoca storica assai recente in Istria ed in alcune isole del golfo del Quarnaro (Brioni Maggiore, Cherso e Plauno. Considerazioni analoghe potrebbero forse essere condotte anche per la diffusione artificiale di Herpestes auropunctatus Hodgson, 1836, su alcune isole della Croazia. Le specie fitofaghe riferibili ai gruppi tassonomici dei lagomorfi e degli artiodattili, e che vengono convenzionalmente comprese nella categoria della cosiddetta "selvaggina", sono tra quelle che hanno più subito un'alterazione condotta in profondità dei quadri faunistici originari, proprio in virtù dell'interesse economico e culturale che ancora rappresentano. Nel caso particolare di queste specie di interesse venatorio ci troviamo quasi sempre di fronte a popolazioni che sono state sottoposte ad intensa gestione e che hanno subito frequenti estinzioni locali seguite da reiterate reintroduzioni. Attualmente, data l'espansione sia naturale che artificiale degli ecotipi indigeni e di quelli alloctoni, si osserva ormai una sovrapposizione degli areali, per cui sembra piuttosto difficile riuscire in

  4. Training for MIS in pediatric urology: proposition of a structured training curriculum.

    Science.gov (United States)

    Escolino, Maria; Turrà, Francesco; Settimi, Alessandro; Esposito, Ciro

    2016-10-01

    In Europe there are a lot of training centers for minimally invasive surgery (MIS) but a standardized MIS training program in pediatric urology doesn't exist at the moment. We performed a literature review with the last goals to propose a structured training curriculum in MIS urology for pediatric surgeons. Pediatric urologists have to obtain a valid MIS training curriculum completing the following 4 steps: (I) Theoretical part (theoretical courses, masterclass) to acquire theoretical knowledge; (II) experimental training (simulation on pelvic trainer, virtual reality simulators, animal models, 3-D ex-vivo models) to acquire basic laparoscopic skills; (III) stages in European centers of reference for pediatric MIS urology to learn all surgery aspects; (IV) personal operative experience. At the end of the training period, the trainee would be expected to perform several MIS urological procedures independently, under supervision of an expert tutor. At the end of the training program, each center will analyze the candidate training booklet and release for each applicant a certification after an exam. We think that this MIS training program in pediatric urology may assure an integrated acquisition of basic and advanced laparoscopic skills during residency training in pediatric urology. Each European country should adopt this program so as to secure a standardized technical qualification in MIS urology for all future pediatric urologists.

  5. Laparoscopic skill laboratory in urological surgery: tools and methods for resident training

    Directory of Open Access Journals (Sweden)

    Fabio C. M. Torricelli

    2011-02-01

    Full Text Available PURPOSE: Laparoscopy has certainly brought considerable benefits to patients, but laparoscopic surgery requires a set of skills different from open surgery, and learning in the operating room may increase surgical time, and even may be harmful to patients. Several training programs have been developed to decrease these potential prejudices. PURPOSES: to describe the laparoscopic training program for urological residents of the "Hospital das Clinicas" of the Sao Paulo Medical School, to report urological procedures that are feasible in dry and wet labs, and to perform a critical analysis of the cost-benefit relation of advanced laparoscopic skills laboratory. MATERIALS AND METHODS: The laparoscopic skill lab has two virtual simulators, three manual simulators, and four laparoscopic sets for study with a porcine model. The urology residents during their first year attend classes in the virtual and manual simulator and helps the senior urological resident in activities carried out with the laparoscopic sets. During the second year, the urological resident has six periods per week, each period lasting four hours, to perform laparoscopic procedures with a porcine model. Results: In a training program of ten weeks, one urological resident performs an average of 120 urological procedures. The most common procedures are total nephrectomy (30%, bladder suture (30%, partial nephrectomy (10%, pyeloplasty (10%, ureteral replacement or transuretero anastomosis (10%, and others like adrenalectomy, prostatectomy, and retroperitoneoscopy. These procedures are much quicker and caused less morbidity. CONCLUSION: Laparoscopic skills laboratory is a good method for achieving technical ability.

  6. Twitter Activity Associated With US News and World Report Reputation Scores for Urology Departments.

    Science.gov (United States)

    Ciprut, Shannon; Curnyn, Caitlin; Davuluri, Meena; Sternberg, Kevan; Loeb, Stacy

    2017-06-29

    To analyze the association between US urology department Twitter presence and U.S. News and World Report (USNWR) reputation scores, to examine the content, informational value, and intended audience of these platforms, and to identify objectives for Twitter use. We identified Twitter accounts for urology departments scored in the 2016-2017 USNWR. Correlation coefficients were calculated between Twitter metrics (number of followers, following, tweets, and Klout influence scores) with USNWR reputation scores. We also performed a detailed content analysis of urology department tweets during a 6-month period to characterize the content. Finally, we distributed a survey to the urology department accounts via Twitter, inquiring who administers the content, and their objectives for Twitter use. Among 42 scored urology departments with Twitter accounts, the median number of followers, following, and tweets were 337, 193, and 115, respectively. All of these Twitter metrics had a statistically significant positive correlation with reputation scores (P reputation, and urologists are considered the most important target audience. There is statistically significant correlation between Twitter activity and USNWR reputation scores for urology departments. Our results suggest that Twitter provides a novel mechanism for urology departments to communicate about academic and educational topics, and social media engagement can enhance reputation. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Long-term urological outcomes in cloacal anomalies.

    Science.gov (United States)

    Caldwell, Brian T; Wilcox, Duncan T

    2016-04-01

    Cloacal anomalies are the most complex and severe form of congenital anorectal malformations (ARM) and urogenital malformations, and it has been well documented that increased severity of ARM leads to worse outcomes. While short-term data on persistent cloaca are available, a paucity of data on long-term outcomes exists, largely because of a lack of uniform terminology, inclusion with other ARM and evolution of the operative technique. On comprehensive review of the published literature on long-term urological outcomes in patients with cloacal anomalies, we found a significant risk of chronic kidney disease and incontinence, however, with improvements in surgical technique, outcomes have improved. Continence often requires intermittent catheterization and in some cases, bladder augmentation. The complexity of cloacal malformations and associated anomalies make long-term multidisciplinary follow-up imperative. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Maintenance antimicrobials in high risk urologic pediatric patients.

    Science.gov (United States)

    McCann, T M; Churchill, B M; Hardy, B E; Arbus, G S

    1982-03-01

    As an alternative to the practice of obtaining repeated laboratory cultures for patients at high risk of renal impairment from recurrent UTI, a program of bone monitoring using a mail-in culture dipspoon was started. A study involving 454 children with neurogenic bladder or other urologic abnormalities showed (1) that the incidence of UTI infection in patients for whom long term antimicrobial therapy had been prescribed was not significantly lower than that in patients who were not on antimicrobials and (2) that at least 50% of dipspoons inoculated due to presentation of UTI symptoms showed no or insignificant growth. These findings suggest that need for further assessment of the efficacy of long term prophylactic antimicrobials in preventing recurrent UTI and the advisability of obtaining a urine culture result before initiating treatment when symptoms are not severe.

  9. [Fuzzy logic in urology. How to reason in inaccurate terms].

    Science.gov (United States)

    Vírseda Chamorro, Miguel; Salinas Casado, Jesus; Vázquez Alba, David

    2004-05-01

    The Occidental thinking is basically binary, based on opposites. The classic logic constitutes a systematization of these thinking. The methods of pure sciences such as physics are based on systematic measurement, analysis and synthesis. Nature is described by deterministic differential equations this way. Medical knowledge does not adjust well to deterministic equations of physics so that probability methods are employed. However, this method is not free of problems, both theoretical and practical, so that it is not often possible even to know with certainty the probabilities of most events. On the other hand, the application of binary logic to medicine in general, and to urology particularly, finds serious difficulties such as the imprecise character of the definition of most diseases and the uncertainty associated with most medical acts. These are responsible for the fact that many medical recommendations are made using a literary language which is inaccurate, inconsistent and incoherent. The blurred logic is a way of reasoning coherently using inaccurate concepts. This logic was proposed by Lofti Zadeh in 1965 and it is based in two principles: the theory of blurred conjuncts and the use of blurred rules. A blurred conjunct is one the elements of which have a degree of belonging between 0 and 1. Each blurred conjunct is associated with an inaccurate property or linguistic variable. Blurred rules use the principles of classic logic adapted to blurred conjuncts taking the degree of belonging of each element to the blurred conjunct of reference as the value of truth. Blurred logic allows to do coherent urologic recommendations (i.e. what patient is the performance of PSA indicated in?, what to do in the face of an elevated PSA?), or to perform diagnosis adapted to the uncertainty of diagnostic tests (e.g. data obtained from pressure flow studies in females).

  10. Environmental oil spill sensitivity atlas for the West Greenland (68 deg.-72 deg. N) coastal zone, 2nd revised edition

    Energy Technology Data Exchange (ETDEWEB)

    Clausen, D.; Johansen, Kasper L.; Mosbech, A.; Boertmann, D.; Wegeberg, S.

    2012-12-15

    This oil spill sensitivity atlas covers the shoreline and the offshore areas of West Greenland between 68 deg. N and 72 deg. N. The coastal zone is divided into 199 shoreline segments and the offshore zone into 8 areas. A sensitivity index value is calculated for each segment/area, and each segment/area is subsequently ranked according to four degrees of sensitivity. Besides this general ranking a number of smaller areas are especially selected as they are of particular significance, they are especially vulnerable to oil spills and they have a size making oil spill response possible. The shoreline sensitivity ranking are shown on 37 maps (in scale 1:250,000), which also show the different elements included and the selected areas. Coast types, logistics and proposed response methods along the coasts are shown on another 37 maps. The sensitivities of the offshore zones are depicted on 4 maps, one for each season. Based on all the information, appropriate oil spill response methods have been assessed for each area. (Author)

  11. On the rms anisotropy at 7 deg and 10 deg observed in the COBE-DMR two year sky maps

    Science.gov (United States)

    Banday, A. J.; Gorski, K. M.; Tenorio, L.; Wright, E. L.; Smoot, G. F.; Lineweaver, C. H.; Kogut, A.; Hinshaw, G.; Bennett, C. L.

    1994-01-01

    The frequency-independent rms temperature fluctuations determined from the Cosmic Background Explorer-Differential Microwave Radiometer (COBE-DMR) two-year sky maps are used to infer the parameter Q(sub rms-PS), which characterizes the normalization of power-law models of primordial cosmological temperature anisotropy, for a forced fit to a scale-invariant Harrison-Zel'dovich (n = 1) spectral model. Using a joint analysis of the 7 deg and 10 deg 'cross'-rms derived from both the 53 and 90 GHz sky maps, we find Q(sub rms-PS) = 17.0(sub -2.1 sup +2.5) micro Kelvin when the low quadrupole is included, and Q(sub rms-PS) = 19.4(sub -2.1 sup +2.3) micro Kelvin excluding the quadrupole. These results are consistent with the n = 1 fits from more sensitive methods. The effect of the low quadrupole derived from the COBE-DMR data on the inferred Q(sub rms-PS) normalization is investigated. A bias to lower Q(sub rms-PS) is found when the quadrupole is included. The higher normalization for a forced n = 1 fit is then favored by the cross-rms technique.

  12. The economics of urologic practice in the twenty-first century.

    Science.gov (United States)

    Holtgrewe, H L

    1998-02-01

    Our nation's health care has been undergoing an economic revolution. The practice of urology has not escaped. Speculation regarding the economics of urologic practice in the twenty-first century must be based on the continuation of policy trends begun over the last decade by government and managed care coupled with the impact of changes in the science of urology, shifting population demographics, and changing social factors. The hallmarks of the years ahead include increased physician accountability, expanded use of clinical care guidelines, continued relentless penetration of managed care, and reduced reimbursement for surgical services.

  13. Cirugía laparoscópica en urología Laparoscopic surgery in urology

    Directory of Open Access Journals (Sweden)

    J. I. Pascual

    2005-01-01

    Full Text Available La cirugía mínimamente invasiva está presente en el momento actual en todos los estándares de calidad de un servicio quirúrgico. La cirugía laparoscópica, base de esta cirugía de mínima invasión, está revolucionando la enseñanza y el manejo de muchas patologías quirúrgicas. En el ámbito urológico, aunque con un retraso de 5 años con respecto a los países de nuestro entorno, la laparoscopia se ha afianzado como una técnica prevalente en muchos procesos del aparato genito-urinario, siendo actualmente la técnica de elección para el tratamiento quirúrgico de la suprarrenal y afianzándose rápidamente en patologías diversas como tumores renales, prostáticos, estadiaje en enfermedades neoplásicas testiculares, patología quirúrgica benigna y en cirugía reconstructiva. El Servicio de Urología del Hospital de Navarra es pionero en el empleo de este tipo de técnicas desde 1995 y desde 1998 en la llamada cirugía laparoscópica avanzada, siendo referente nacional en alguno de los procedimientos como la adrenalectomía laparoscópica. Actualmente están incorporados en el servicio todos los procedimientos laparoscópicos avanzados en urología, con una curva de aprendizaje superada. Todo ello ha permitido mejorar la atención al paciente, consiguiendo una disminución del dolor postoperatorio, estancia hospitalaria y rápida reincorporación a la actividad laboral con unos resultados oncológicos superponibles a los de la cirugía abierta.At the present time minimally invasive surgery is present in all the standards of quality of a surgical service. Laparoscopic surgery, the basis of this minimally invasive surgery, is revolutionising the teaching and handling of many surgical pathologies. In the urological sphere, although with a delay of 5 years with respect to neighbouring countries, laparoscopy has become established as a prevalent technique in many processes of the urinary-genital apparatus. At present it is the chosen

  14. Dislocation Majorana zero modes in perovskite oxide 2DEG

    Science.gov (United States)

    Chung, Suk Bum; Chan, Cheung; Yao, Hong

    2016-05-01

    Much of the current experimental efforts for detecting Majorana zero modes have been centered on probing the boundary of quantum wires with strong spin-orbit coupling. The same type of Majorana zero mode can also be realized at crystalline dislocations in 2D superconductors with the nontrivial weak topological indices. Unlike at an Abrikosov vortex, at such a dislocation, there is no other low-lying midgap state than the Majorana zero mode so that it avoids usual complications encountered in experimental detections such as scanning tunneling microscope (STM) measurements. We will show that, using the anisotropic dispersion of the t2g orbitals of Ti or Ta atoms, such a weak topological superconductivity can be realized when the surface two-dimensional electronic gas (2DEG) of SrTiO3 or KTaO3 becomes superconducting, which can occur through either intrinsic pairing or proximity to existing s-wave superconductors.

  15. Giant magnetic quadrupole resonance studied with 180 deg. electron scattering

    CERN Document Server

    Neumann-Cosel, P V

    1999-01-01

    The nuclei sup 4 sup 8 Ca and sup 9 sup 0 Zr were investigated in 180 deg. high-resolution inelastic electron scattering for momentum transfers q approx =0.35-0.8 fm sup - sup 1. Complete M2 strength distributions could be extracted in both nuclei up to excitation energies of about 15 MeV utilizing a fluctuation analysis technique. Second-RPA calculations successfully describe the experimentally observed strong fragmentation of the M2 mode. The quenching of the spin part is found to be comparable to the M1 case, contrary to previous claims suggesting a stronger reduction. A quantitative reproduction of the data requires the presence of appreciable orbital strength which can be interpreted as a torsional elastic vibration (the so-called twist mode).

  16. Laicità: finitezza degli ordini e governo delle differenze

    Directory of Open Access Journals (Sweden)

    Nicola Colaianni

    2013-12-01

    Full Text Available Testo della relazione al Convegno Nazionale dell’ADEC sul tema “Per una disciplina che cambia. Il diritto canonico e il diritto ecclesiastico nel tempo presente” (Bologna, 7-9 novembre 2013, destinata alla pubblicazione negli Atti del Convegno. Contributo non sottoposto a valutazioneSOMMARIO: 1. La laicità dei giudici – 2. La laicità dei giuristi – 3. Né regola né valore: un principio – 4. La finitezza degli ordini distinti: dalle materie miste alla sfera dell’indecidibile – 5. L’aconfessionalità sostanziale: a ex parte ecclesiae – 6. (segue: b ex parte status – 7. La laicità come governance delle differenze.

  17. LA FORMAZIONE DEGLI ETNICI NELLA RIFLESSIONE LINGUISTICA DI FRANCESCO CHERUBINI

    Directory of Open Access Journals (Sweden)

    Federica Guerini

    2016-09-01

    Full Text Available Il presente contributo si propone di fornire una descrizione della struttura del Vocabolario Patronimico di Francesco Cherubini e delle fonti empiriche consultate per la sua compilazione. Si accennerà poi a due questioni ricorrenti nel dibattito sulla formazione degli etnici in italiano, ovvero, la presenza di varianti allomorfiche o suppletive, e la motivazione morfo-pragmatica sottesa all’impiego di alcuni suffissi derivativi nella formazione di etnici e aggettivi deonomastici, cercando di chiarire quale attenzione tali tematiche abbiano ricevuto nella riflessione linguistica di Francesco Cherubini. Si formuleranno infine alcune osservazioni conclusive, evidenziando luci ed ombre del Vocabolario Patronimico e sottolineando alcuni degli spunti che tale opera ancora può offrire agli studiosi contemporanei. The formation of ethnic words in Francesco Cherubini’s reflection on language  The aim of this paper is to describe the structure and contents of Francesco Cherubini’s Vocabolario Patronimico, as well as the empirical sources consulted for its compilation. We will address two of the most common issues in the debate on the formation of ethnic nouns and adjectives in Italian, namely the existence of allomorphs and supplementary variants, and the morpho-pragmatic motivation displayed by some of the derivative suffixes occurring in ethnic nouns and adjectives derived from both personal and place names. We will offer a few observations on the place occupied by the above-mentioned issues in Cherubini’s thought and, by analyzing the strengths and weaknesses of the Vocabolario Patronimico, we will draw attention to a few topics which may be of some interest to contemporary scholars.

  18. A new methodology to identify surface water bodies at risk by using pesticide monitoring data: The glyphosate case study in Lombardy Region (Italy).

    Science.gov (United States)

    Di Guardo, Andrea; Finizio, Antonio

    2017-08-14

    In the last decades, several monitoring programs were established as an effect of EU Directives addressing the quality of water resources (drinking water, groundwater and surface water). Plant Protection Products (PPPs) are an obvious target of monitoring activities, since they are directly released into the environment. One of the challenges in managing the risk of pesticides at the territorial scale is identifying the locations in water bodies needing implementation of risk mitigation measures. In this, the national pesticides monitoring plans could be very helpful. However, monitoring of pesticides is a challenging task because of the high number of registered pesticides, cost of analyses, and the periodicity of sampling related to pesticide application and use. Extensive high-quality data-sets are consequently often missing. More in general, the information that can be obtained from monitoring studies are frequently undervalued by risk managers. In this study, we propose a new methodology providing indications about the need to implement mitigation measures in stretches of surface water bodies on a territory by combining historical series of monitoring data and GIS. The methodology is articulated in two distinct phases: a) acquisition of monitoring data and setting-up of informative layers of georeferenced data (phase 1) and b) statistical and expert analysis for the identification of areas where implementation of limitation or mitigation measures are suggested (phase 2). Our methodology identifies potentially vulnerable water bodies, considering temporal contamination trends and relative risk levels at selected monitoring stations. A case study is presented considering glyphosate monitoring data in Lombardy Region (Northern of Italy) for the 2008-2014 period. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Best practices recommendations in the application of immunohistochemistry in urologic pathology: report from the International Society of Urological Pathology consensus conference.

    Science.gov (United States)

    Amin, Mahul B; Epstein, Jonathan I; Ulbright, Thomas M; Humphrey, Peter A; Egevad, Lars; Montironi, Rodolfo; Grignon, David; Trpkov, Kiril; Lopez-Beltran, Antonio; Zhou, Ming; Argani, Pedram; Delahunt, Brett; Berney, Daniel M; Srigley, John R; Tickoo, Satish K; Reuter, Victor E

    2014-08-01

    Members of the International Society of Urological Pathology (ISUP) participated in a half-day consensus conference to discuss guidelines and recommendations regarding best practice approaches to use of immunohistochemistry (IHC) in differential diagnostic situations in urologic pathology, including bladder, prostate, testis and, kidney lesions. Four working groups, selected by the ISUP leadership, identified several high-interest topics based on common or relevant challenging diagnostic situations and proposed best practice recommendations, which were discussed by the membership. The overall summary of the discussions and the consensus opinion forms the basis of a series of articles, one for each organ site. This Special Article summarizes the overall recommendations made by the four working groups. It is anticipated that this ISUP effort will be valuable to the entire practicing community in the appropriate use of IHC in diagnostic urologic pathology.

  20. [Urology and National Socialism: the fate of Alexander von Lichtenberg 1880-1949].

    Science.gov (United States)

    Moll, F H; Krischel, M; Rathert, P; Fangerau, H

    2010-09-01

    Alexander von Lichtenberg (1880-1949) was one of the famous members of the German Urological Society (DGU) in pre-war Germany. He introduced excretion urography and a special TURP Instrument. In 1928 he was president of the 8th meeting held in the German capital Berlin. His Handbook of Urology, released by Ferdinand Springer publishing house, was a trendsetter in establishing urology as a specialty in Germany and bringing together the whole wisdom of all aspects of urology. He was the founder of the famous Maximilian Nitze Award of the DGU. As a Jew he-like many others-was forced to leave Nazi Germany after 1933. Even in Hungary, his native country, he again had to resist anti-Semitic hostility. Later on he lived in Mexico. Alexander von Lichtenberg has to be remembered with special focus on the exodus of German Jewish scientists during the Nazi time.

  1. DISEASES OF THE GENITOURINARY SYSTEM IN HIV INFECTION–A NEW PROBLEM OF MODERN UROLOGY

    Directory of Open Access Journals (Sweden)

    S. K. Yarovoy

    2015-01-01

    Full Text Available The article presents the results of a retrospective analysis of the provision of urological care 352 HIV-infected patients in the Urological City Clinical Hospital №47 of Moscow Health Department for the period 1996–2012. We estimated of income dynamics of HIV-infected patients in urological hospital, studied the distribution of these patients for urological nosology and stage of HIV infection. We noted the predominance of acute infectious and inflammatory diseases of the genitourinary system, that require immediate initiation of antibiotic therapy in the empirical mode, and in some cases, emergency surgery. We detected the predisposition to acute infectious and inflammatory diseases of the scrotum is a feature of HIV-infected patients.Article is supplemented with analysis of the effectiveness of the main pharmacological groups of antibacterial drugs for the treatment of nonspecific infectious and inflammatory diseases of the urogenital system in patients with HIV infection.

  2. International Society of Urological Pathology grading and other prognostic factors for renal neoplasia.

    Science.gov (United States)

    Delahunt, Brett; Srigley, John R; Egevad, Lars; Montironi, Rodolfo

    2014-11-01

    The International Society of Urological Pathology convened an international consensus conference in 2012 to review aspects relating to the prognostic assessment, classification, and diagnosis of adult renal malignancy. The detailed recommendations of the conference are reported.

  3. [Dr. Puigvert and Archivos Españoles de Urología].

    Science.gov (United States)

    Pérez Albacete, Mariano

    2006-04-01

    For the celebration of the first Century of Dr. Antonio Puigvert Gorro's birth we want to know his contribution to and relationship with Archivos Españoles de Urología. We review all articles published by Dr. Puigvert, and additionally all articles with reference to his person and his work; we also review his written works and biography. He was one of the founders of the journal and always maintained a great cooperation until the '70s; he published important works in it, which are analyzed. We also emphasize his contribution to Urology in addition to his dedication to the history of the speciality. Dr. Puigvert is one of the most distinguished figures in the Spanish Urology, with an immense working capacity and written works. In his works published in Archivos he presents the results of his observations and his studies, as well as part of his innovations, ideas, and discoveries, that he later left in his urology books.

  4. Knowledge about urology in the general population of Jeddah, Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Ghassan A Barayan

    2011-01-01

    Conclusion : Although significant proportion of our population know little about the field of urology, the overall result is better when compared to North American population. The clarity of Arabic terminology related to the field may explain the difference.

  5. The Role of Scarless Procedures in Urology: A Review of Literature

    African Journals Online (AJOL)

    urological literature, as a new surgical intervention to access ... to the retraction of organs, bleeding control, and handling of ... surgical trauma and to enhance cosmesis, a scarless ... reduced wound infection and postoperative pain. (6).

  6. [Development of the Stettin municipal hospital. The beginnings of urology in Stettin (1.)].

    Science.gov (United States)

    Zajaczkowski, T; Wojewski-Zajaczkowski, E M

    2005-01-01

    The growth of the city's population, rapid advances in medical science, the increasing understanding of the importance of hygiene and, finally, the demand for health care led to the erection of a modern 353-bed municipal hospital complex at Pommerensdorf, Apfelallee, which was officially opened in 1879. From the very beginning of its existence, the municipal hospital was constantly in the process of extension and rebuilding. A hospital base was set up and new departments and clinics were opened. In 1937, the number of the hospital beds had increased to 1,004. The official existence of an independent urology department with 30 beds, first headed by Dr. Felix Hagen (1880-1962), dates back to March 1919. The aim of this new department was to carry out examinations and differential diagnoses, together with the department of internal medicine, for those patients from the urological surgery sector including evaluation for surgery. Surgical urology was the responsibility of the surgery department. The remaining cases requiring urological experience, such as those involving transurethral intervention, diseases of the bladder and urinary tract infection, were treated in the new urology department. As an auxiliary department, de facto dependent on the departments of surgery and internal medicine, urology could not develop properly and survive. In October 1935, the position of the head of the urological department was terminated, and urology was incorporated into the department of surgery. During the Second World War, between 1939 and 1945, as during the World War 1, a field hospital was set up in the municipal hospital at Pommerensdorf in Stettin.

  7. Prevalence and management status of urologic diseases in geriatric hospitals in South Korea: A field research

    Science.gov (United States)

    Lee, Sang Heon; Suh, Jungyo; Kim, Hyung Suk; Lee, Young Ju; Lee, Sang Rim; Kim, Khae Hawn

    2017-01-01

    Purpose We aimed to investigate the current management status of urologic diseases in geriatric hospitals in South Korea. Materials and Methods Questionnaire surveys and in-depth person-to-person interviews were conducted at 13 hospitals within the Seoul and Incheon areas. Results The study was carried out from July to December 2014; 75.6% of patients (1,858/2,458) and 77.5% (779/1,031) of medical personnel responded to our survey. All surveys and interviews were performed by urology specialists, fellows, residents, or nurses. The hospitals included in the study had an average of 215.2 beds (range, 110–367), 189.1 patients (range, 90–345), and 40.2 nurses (range, 10–83). The average number of physicians was 6.2 (range, 3–11), but none of these were certified urologists. Only 4 hospitals provided consultation services for urological disorders. In total, 64% of patients had urological disorders, although only 20.7% of patients were receiving medication. Most patients were being treated using urological interventions; diapers (49.7%), indwelling catheters (19.5%), clean intermittent catheters (12.2%), and external collection urinary drainage (7.9%). However, most interventions were inadequately implemented, and only 17% of the patients had been examined by a certified urologist. Urological complications were found in 20.2% of patients, and secondary complications occurred in 18.8%. Excluding redundant cases, the total prevalence of urological complications was 39.0%. Conclusions Urologic diseases are poorly managed, and no certified urologists work in geriatric hospitals. Therefore, more designated urologists are needed in geriatric hospitals. PMID:28097271

  8. Long-term follow-up and late complications following treatment of pediatric urologic disorders.

    Science.gov (United States)

    Akhavan, Ardavan; Stock, Jeffrey A

    2011-01-01

    Many pediatric urologic disorders have sequelae that may affect patients well into adulthood. Despite adequate treatment, many patients are at risk for progressive urologic deterioration years after surgical reconstruction. While many pediatric urologists follow their patients years after surgery, screening for late complications is a shared responsibility with primary care providers. This article discusses potential late complications and appropriate follow-up for patients who have a history of ureteral reimplantation, pyeloplasty, hypospadias repair, posterior urethral valve ablation, and intestinal interposition.

  9. Globalization in Urology: A Bibliographical Analysis of Cross-Continent Publication between 2002 and 2012.

    Science.gov (United States)

    Mani, Jens; Juengel, Eva; Bartsch, Georg; Filmann, Natalie; Ackermann, Hanns; Nelson, Karen; Haferkamp, Axel; Engl, Tobias; Blaheta, Roman A

    2015-01-01

    Asian scientists have now increasingly begun to contribute to globalization; yet it is not clear whether publishing in the field of urology is paralleled by elevated cross-continental scientific publishing. An exemplary bibliometric analysis of urologic journals from 3 different continents was conducted between 2002 and 2012. Based on the ISI Web of Knowledge Journal Citation Reports, 2 urologic journals with similar impact factors (IFs) in 2013 were selected from Europe ('British Journal of Urology International', 'World Journal of Urology'), Asia ('International Journal of Urology', 'Asian Journal of Andrology') and North America ('Urologic Oncology-Seminars and Original Investigations', 'Urology'). The home continent of the journal, the workplace continental affiliation of the last author, article type (clinical, experimental or review) as well as the IF were documented. Most authors published their manuscripts in journals from the same continent in which they worked. However, a significant increase in cross-continental publishing was apparent from 2002 to 2012. Asians publishing in North America increased from 17% in 2002 to 35% in 2012. Europeans also increased the number of articles they published in North American journals, while publications from North American authors were shifted towards both European and Asian journals. Experimental and clinical articles showed significant increases in cross-continental publishing, while review publishing showed no significant change. The average IF for authors from all 3 continents increased from 2002 to 2012 (p < 0.001). The largest increase in the IF was found for Asian authors (0.11 per year). Cross-continental publication significantly increased during the period from 2002 to 2012. The impact that the Asian authors have experienced was found to be gradually impacting the North American and European colleagues. © 2015 S. Karger AG, Basel.

  10. A review of routinely collected data studies in urology: Methodological considerations, reporting quality, and future directions.

    Science.gov (United States)

    Welk, Blayne; Kwong, Justin

    2017-01-01

    Studies using routinely collected data (RCD) are common in the urological literature; however, there are important considerations in the creation and review of RCD discoveries. A recent reporting guideline (REporting of studies Conducted using Observational Routinely-collected health Data, RECORD) was developed to improve the reporting of these studies. This narrative review examines important considerations for RCD studies. To assess the current level of reporting in the urological literature, we reviewed all the original research articles published in Journal of Urology and European Urology in 2014, and determined the proportion of the RECORD checklist items that were reported for RCD studies. There were 56 RCD studies identified among the 608 articles. When the RECORD items were considered applicable to the specific study, they were reported in 52.5% of cases. Studies most consistently (>80% of them) reported the names of the data sources, the study time frame, the extent to which the authors could access the database source, the patient selection, and discussed missing data. Few studies (RCD studies may serve to increase the quality of these studies in the urological literature. With increased technological integration in healthcare and the proliferation of electronic medical records, RCD will continue to be an important source for urological research.

  11. The Publication Ranking Score for pediatric urology: quantifying thought leadership within the subspecialty.

    Science.gov (United States)

    Lloyd, Jessica C; Madden-Fuentes, Ramiro J; Nelson, Caleb P; Kokorowski, Paul J; Wiener, John S; Ross, Sherry S; Kutikov, Alexander; Routh, Jonathan C

    2013-12-01

    Clinical care parameters are frequently assessed by national ranking systems. However, these rankings do little to comment on institutions' academic contributions. The Publication Ranking Score (PRS) was developed to allow for objective comparisons of scientific thought-leadership at various pediatric urology institutions. Faculty lists were compiled for each of the US News & World Report (USNWR) top-50 pediatric urology hospitals. A list of all faculty publications (2006-2011) was then compiled, after adjusting for journal impact factor, and summed to derive a Publication Ranking Score (PRS). PRS rankings were then compared to the USNWR pediatric urology top-50 hospital list. A total of 1811 publications were indexed. PRS rankings resulted in a mean change in rank of 12 positions, compared to USNWR ranks. Of the top-10 USNWR hospitals, only 4 were ranked in the top-10 by the PRS. There was little correlation between the USNWR and PRS ranks for either top-10 (r = 0.42, p = 0.23) or top-50 (r = 0.48, p = 0.0004) hospitals. PRS institutional ranking differs significantly from the USNWR top-50 hospital list in pediatric urology. While not a replacement, we believe the PRS to be a useful adjunct to the USNWR rankings of pediatric urology hospitals. Copyright © 2013 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

  12. Urologic complication in laparoscopic radical hysterectomy: meta-analysis of 20 studies.

    Science.gov (United States)

    Hwang, Jong Ha

    2012-11-01

    A meta-analysis was done to assess the risk of intraoperative and postoperative urologic complications, and laparoscopic radical hysterectomy (LRH) and lymph node dissection. Pubmed, EMBASE and Cochrane library were searched for studies published to December, 2011, supplemented by manual searches of relevant bibliographies from the retrieved articles. Two researchers independently extracted the data. Eligible studies had reported perioperative complications and a sample size of at least 10 patients. The search yielded 19 retrospective studies and one prospective cohort study (intraoperative urologic complication, 18 studies; postoperative urologic complication, 16 studies). When all studies were pooled, the odds ratio (OR) of LRH for the risk of intraoperative urologic complications compared to abdominal radical hysterectomy (ARH) was 1.97 [95% confidence interval (CI) 1.23-3.13] and the OR of LRH for postoperative complication risk compared to ARH was 1.35 [95% CI 0.84-2.16]. In subgroup analysis, obesity and laparoscopic type (laparoscopic assisted vaginal radical hysterectomy) were associated with intraoperative urologic complications. Laparoscopic radical hysterectomy is associated with a significant increased risk of intraoperative urologic complications. Copyright © 2012. Published by Elsevier Ltd.

  13. Institutional Review Board approval and innovation in urology: current practice and safety issues.

    Science.gov (United States)

    Sundaram, Varun; Vemana, Goutham; Bhayani, Sam B

    2014-02-01

    To retrospectively review recent publications describing novel procedures/techniques, and describe the Institutional Review Board (IRB)/ethics approval process and potential ethical dilemmas in their reporting. We searched PubMed for papers about innovative or novel procedures/techniques between 2011 and August 2012. A query of titles/abstracts in the Journal of Urology, Journal of Endourology, European Urology, BJU International, and Urology identified relevant papers. These results were reviewed for human studies that described an innovative technique, procedure, approach, initial series, and/or used new technology. In all, 91 papers met criteria for inclusion; 25 from the Journal of Endourology, 14 from the Journal of Urology, nine from European Urology, 15 from the BJU International and 28 from Urology. IRB/ethics approval was given for an experimental procedure or database in 24% and 22%, respectively. IRB/ethics approval was not mentioned in 52.7% of studies. Published IRB/ethics approvals for innovative techniques are heterogeneous including database, retrospective, and prospective approvals. Given the concept that innovations are likely not in the legal or ethical standard of care, strong consideration should be given to obtaining IRB/ethics approval before the actual procedure, instead of approval to merely report database outcomes. © 2013 The Authors. BJU International © 2013 BJU International.

  14. A 360-deg Digital Image Correlation system for materials testing

    Science.gov (United States)

    Genovese, K.; Cortese, L.; Rossi, M.; Amodio, D.

    2016-07-01

    The increasing research interest toward natural and advanced engineered materials demands new experimental protocols capable of retrieving highly dense sets of experimental data on the full-surface of samples under multiple loading conditions. Such information, in fact, would allow to capture the possible heterogeneity and anisotropy of the material by using up-to-date inverse characterization methods. Although the development of object-specific test protocols could represent the optimal choice to address this need, it is unquestionable that universal testing machines (UTM) remain the most widespread and versatile option to test materials and components in both academic and industrial contexts. A major limitation of performing standard material tests with UTM, however, consists in the scarce information obtainable with the commonly associated sensors since they provide only global (LVDTs, extensometers, 2D-video analyzers) or local (strain gages) measures of displacement and strain. This paper presents a 3D Digital Image Correlation (DIC) system developed to perform highly accurate full-surface 360-deg measurements on either standard or custom-shaped samples under complex loading within universal testing machines. To this aim, a low cost and easy to setup video rig was specifically designed to overcome the practical limitations entailed with the integration of a multi-camera system within an already existing loading frame. In particular, the proposed system features a single SLR digital camera moved through multiple positions around the specimen by means of a large rotation stage. A proper calibration and data-processing procedure allows to automatically merge the experimental data obtained from the multiple views with an accuracy of 10-2 m m . The results of a full benchmarking of the metrological performances of the system are here reported and discussed together with illustrative examples of full-360-deg shape and deformation measurements on a Grade X65 steel

  15. Critical appraisal of technical problems with robotic urological surgery.

    Science.gov (United States)

    Nayyar, Rishi; Gupta, Narmada P

    2010-06-01

    To record the technical problems and complications associated with the use of da Vinci S robotic system (Intuitive Surgical, Sunnyvale, CA, USA) and to review previous reports. We analysed our records for all machine- or instrument-related errors during the course of 340 consecutive robot-assisted urological operations at our centre from July 2006 to March 2009, using one robotic machine. The cause of the error (machine or human), troubleshooting methods and consequences of the errors were evaluated. The overall device failure rate was 10.9% (37/340). The most frequent technical problems were related to robotic instruments (23/37). Other failures included colour/hue changes in the console image, intermittent double vision, fused illuminator bulb and problems with the master tool-manipulator device (hand-piece unit), patient cart circuitry, patient-side manipulator arm, closed-circuit camera unit or camera cable. Of 37 problems, 28 (76%) were surmountable during the course of surgery. The overall conversions to standard open/laparoscopic procedure attributable to mechanical failures of the robot were 0.6% (2/340). There were no complications or direct harm to the patient in any case. Most faults could be corrected or bypassed with some addition to operating room time. Despite an association of various types of new technical problems with robotic surgery, it provides a safe mode of minimally invasive surgery with very low conversion rates attributable to it, and no direct patient injury.

  16. Extracellular MicroRNAs in Urologic Malignancies: Chances and Challenges

    Directory of Open Access Journals (Sweden)

    Liang Wang

    2013-07-01

    Full Text Available Small noncoding RNAs that are 19-23 nucleotides long, known as microRNAs (miRNAs, are involved in almost all biological mechanisms during carcinogenesis. Recent studies show that miRNAs released from live cells are detectable in body fluids and may be taken up by other cells to confer cell-cell communication. These released miRNAs (here referred to as extracellular miRNAs are often protected by RNA-binding proteins or embedded inside circulating microvesicles. Due to their relative stability, extracellular miRNAs are believed to be promising candidates as biomarkers for diagnosis and prognosis of disease, or even as therapeutic agents for targeted treatment. In this review, we first describe biogenesis and characteristics of these miRNAs. We then summarize recent publications involving extracellular miRNA profiling studies in three representative urologic cancers, including: prostate cancer, bladder cancer, and renal cell carcinoma. We focus on the diagnostic, prognostic, and therapeutic potential of these miRNAs in biological fluids, such as serum, plasma, and urine. Finally, we discuss advantages and challenges of these miRNAs in clinical applications.

  17. [Oswald Schwarz: a pioneer in psychosomatic urology and sexual medicine].

    Science.gov (United States)

    Berberich, H J; Schultheiss, D; Kieser, B

    2015-01-01

    Oswald Schwarz, a urologist from Vienna, was a scholar of Anton Ritter von Frisch and Hans Rubritius. As a physician during World War I, he was confronted with numerous bullet wounds to the spinal cord. In 1919, he completed his professorial thesis"Bladder dysfunction as a result of bullet wounds to the spinal cord". Oswald Schwarz was known as a committed surgeon. As an urologist he also treated patients with sexual dysfunction. Besides his practical and scientific urology-related work, he was also interested in psychology and philosophy. He held lectures on both subjects earning himself the nickname, the Urosoph. In the 1920s, Oswald Schwarz belonged to the inner circle of Alfred Adler, the founder of Individual Psychology, and was editor of the first psychosomatic textbook published in German, "Psychological origin and psychotherapy of physical symptoms" (1925). In addition, Schwarz wrote numerous articles and several books on sexual medicine. He also made many valuable contributions to the development of medical anthropology. Altogether, his work includes over 130 publications. Faced with the rise of fascism and National Socialism in Europe, Oswald Schwarz, who was of Jewish origin, emigrated to England in 1934. There he died in 1949. Unfortunately his scientific work has largely been forgotten. The aim of the following article is to remind us of his important contributions to the field.

  18. Digital engagement in nursing: a urology nurse's journey.

    Science.gov (United States)

    Brocksom, Jane E

    The use of technology is transforming society-underpinning communication, information gathering and collaboration. Indeed, 2013 may prove to be the tipping point for healthcare delivery. No longer are policies and guidance documents being produced solely on the basis of cautions and negatives. We are entering a new era. Documents are now being produced that are constructive, focusing equally on positives and collaboration. Digital engagement within nursing and healthcare communities can be a tremendously positive experience; with the help of online resources, we can be part of the tipping point. From micro blogging to content communities, from collaborative projects to social networking, Web2.0 technology is providing 21st-century practitioners with opportunities we have not yet fully realised the potential of-for ourselves, our patients or our institutions. In this article, I share my personal journey, aiming to show my fellow healthcare practitioners how these technologies might be used to inform and improve nursing practice, within urology and beyond.

  19. Secondary data sources for health services research in urologic oncology.

    Science.gov (United States)

    Cole, Alexander P; Friedlander, David F; Trinh, Quoc-Dien

    2017-09-11

    Though secondary data analyses of large datasets may reduce logistical and financial barriers required to perform significant and innovative work, such research requires specialized skills in data handling and statistical techniques as well as thorough and detailed knowledge of the data sources being used. To provide an overview of several common types of secondary data, focusing on strengths, weaknesses and examples of how these data may be used for health services research. Secondary data comprise a broad and heterogeneous category. This review covers several large categories of such data with examples of their use and discussions about their strengths and weaknesses. Sources include administrative data, claims-based datasets, electronic health records health surveys, patient or disease or both registries, quality improvement initiatives, as well as data from existing trials. Linkages of different types of data may expand the scope of questions answerable using secondary data analysis. Specific strengths and weaknesses of each type of dataset are discussed along with examples from the recent urologic literature. Choice of the appropriate data source should be tailored to the specific research question as well as the research resources and expertise available. Appropriate decisions about which data to use are the foundation for valid, high-impact research using secondary data. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. COSMOS Photometric Redshifts with 30-bands for 2-deg2

    CERN Document Server

    Ilbert, O; Salvato, M; Aussel, H; McCracken, H J; Sanders, D B; Scoville, N; Kartaltepe, J; Arnouts, S; Le Floc'h, E; Mobasher, B; Taniguchi, Y; Lamareille, F; Leauthaud, A; Sasaki, S; Thompson, D; Zamojski, M; Zamorani, G; Bardelli, S; Bolzonella, M; Bongiorno, A; Brusa, M; Caputi, K I; Carollo, C M; Contini, T; Cook, R; Coppa, G; Cucciati, O; De la Torre, S; de Ravel, L; Franzetti, P; Garilli, B; Hasinger, G; Iovino, A; Kampczyk, P; Kneib, J -P; Knobel, C; Kovac, K; Le Borgne, J F; Le Brun, V; Le Fèvre, O; Lilly, S; Looper, D; Maier, C; Mainieri, V; Mellier, Y; Mignoli, M; Murayama, T; Pellò, R; Peng, Y; Pérez-Montero, E; Renzini, A; Ricciardelli, E; Schiminovich, D; Scodeggio, M; Shioya, Y; Silverman, Joseph; Surace, J; Tanaka, M; Tasca, L; Tresse, L; Vergani, D; Zucca, E

    2008-01-01

    We present accurate photometric redshifts in the 2-deg2 COSMOS field. The redshifts are computed with 30 broad, intermediate, and narrow bands covering the UV (GALEX), Visible-NIR (Subaru, CFHT, UKIRT and NOAO) and mid-IR (Spitzer/IRAC). A chi2 template-fitting method (Le Phare) was used and calibrated with large spectroscopic samples from VLT-VIMOS and Keck-DEIMOS. We develop and implement a new method which accounts for the contributions from emission lines (OII, Hbeta, Halpha and Ly) to the spectral energy distributions (SEDs). The treatment of emission lines improves the photo-z accuracy by a factor of 2.5. Comparison of the derived photo-z with 4148 spectroscopic redshifts (i.e. Delta z = zs - zp) indicates a dispersion of sigma_{Delta z/(1+zs)}=0.007 at i<22.5, a factor of 2-6 times more accurate than earlier photo-z in the COSMOS, CFHTLS and COMBO-17 survey fields. At fainter magnitudes i<24 and z<1.25, the accuracy is sigma_{Delta z/(1+zs)}=0.012. The deep NIR and IRAC coverage enables the ph...

  1. LE ZANZARE ITALIANE: GENERALITÀ E IDENTIFICAZIONE DEGLI ADULTI (DIPTERA, CULICIDAE

    Directory of Open Access Journals (Sweden)

    Francesco Severini

    2009-12-01

    Full Text Available Nel presente lavoro vengono riportate le informazioni essenziali su tassonomia e biologia nonché sugli aspetti ecologici degli adulti dei Culicidi italiani. Attualmente la fauna culicidica italiana comprende 64 specie appartenenti a 2 sottofamiglie e 8 generi. Alla sottofamiglia Anophelinae appartiene soltanto il genere Anopheles, presente con 16 specie raggruppate in due sottogeneri. Alla sottofamiglia Culicinae appartengono i rimanenti 7 generi: Aedes con 6 specie raggruppate in 3 sottogeneri, Coquillettidia con 2 specie, Ochlerotatus con 20 specie raggruppate in 3 sottogeneri, Culex con 12 specie raggruppate in 4 sottogeneri, Culiseta con 6 specie raggruppate in 3 sottogeneri, Orthopodomyia e Uranotaenia con una specie ognuna. In questo contesto vengono fornite le chiavi di identificazione specifica per le zanzare adulte, in italiano e in inglese. Le chiavi sono corredate da un’ampia iconografia (figure 1-75. Alle chiavi fa seguito la diagnosi morfologica dell’adulto di ogni specie con note sulla relativa biologia e distribuzione. Per ulteriori approfondimenti viene riportata la bibliografia completa sulle zanzare della fauna italiana dal 1960 ed i precedenti lavori più autorevoli.

  2. Come e cosa desidera la narrativa italiana degli anni Zero

    Directory of Open Access Journals (Sweden)

    Gianluigi Simonetti

    2013-05-01

    Full Text Available L'articolo analizza il trattamento del tema del desiderio - erotico e amoroso - nel romanzo italiano degli ultimi anni, impegnandosi nell'esame ravvicinato di alcuni testi esemplari. La campionatura vuole da un lato isolare alcune opere rappresentative della situazione attuale della narrativa contemporanea, dall'altro  proporre un'ipotesi categoriale che seziona il campo di studio in tre parti; il sondaggio sembra infatti suggerire che le dinamiche del desiderio vengono rese in maniera specifica nei diversi ambiti della letteratura di consumo, in quella di 'nobile intrattenimento' e in quella 'forte' e letterariamente più ambiziosa. L'analisi formale risulta insomma integrata a una prospettiva di stroria dello stile, secondo un metodo che permette di utilizzare la figuralità letteraria come 'indicatore sociologico' di processi politici (e forse antropologici in atto.

  3. Le caratteristiche degli acquirenti e venditori di abitazioni

    Directory of Open Access Journals (Sweden)

    Erika Ghiraldo

    2011-12-01

    Full Text Available L’incrocio dei dati contenuti nelle dichiarazioni dei redditi con quelli contenuti negli archivi della Pubblicità Immobiliare (ex Conservatorie rende disponibili molte informazioni sulle caratteristiche dei contraenti che hanno effettuato una compravendita di unità immobiliari. Considerando principalmente le compravendite di unità immobiliari del settore residenziale effettuate da persone fisiche sono trattate informazioni sul reddito dichiarato al fisco, l’età e l’attività di lavoro prevalente. È fornito un quadro sintetico della distribuzione delle compravendite, in termini di Numero di Transazioni Normalizzate (NTN e per dimensione delle abitazioni, per ciascuna caratteristica sia per gli acquirenti che per i venditori. La disponibilità dell’informazione sulla residenza dei soggetti consente, inoltre, di condurre un’analisi sulla provenienza degli acquirenti rispetto al luogo di ubicazione dell’immobile compravenduto. E’ possibile così analizzare la composizione del mercato distinguendo la quota di acquisti imputabile a soggetti residenti nello stesso Comune di ubicazione dell’immobile (mercato comunale dalla quota alimentata da soggetti residenti in altro Comune di una stessa provincia (mercato infraprovinciale o di altra provincia (mercato extra-provinciale. Quest’ultima indagine risulta molto interessante se effettuata su singole città. Sono, quindi, riportati i risultati dell’analisi per i mercati delle città di Milano, Roma e Napoli.

  4. EAU guidelines on robotic and single-site surgery in urology.

    Science.gov (United States)

    Merseburger, Axel S; Herrmann, Thomas R W; Shariat, Shahrokh F; Kyriazis, Iason; Nagele, Udo; Traxer, Olivier; Liatsikos, Evangelos N

    2013-08-01

    This is a short version of the European Association of Urology (EAU) guidelines on robotic and single-site surgery in urology, as created in 2013 by the EAU Guidelines Office Panel on Urological Technologies. To evaluate current evidence regarding robotic and single-site surgery in urology and to provide clinical recommendations. A comprehensive online systematic search of the literature according to Cochrane recommendations was performed in July 2012, identifying data from 1990 to 2012 regarding robotic and single-site surgery in urology. There is a lack of high-quality data on both robotic and single-site surgery for most upper and lower urinary tract operations. Mature evidence including midterm follow-up data exists only for robot-assisted radical prostatectomy. In the absence of high-quality data, the guidelines panel's recommendations were based mostly on the review of low-level evidence and expert opinions. Robot-assisted urologic surgery is an emerging and safe technology for most urologic operations. Further documentation including long-term oncologic and functional outcomes is deemed necessary before definite conclusions can be drawn regarding the superiority or not of robotic assistance compared with the conventional laparoscopic and open approaches. Laparoendoscopic single-site surgery is a novel laparoscopic technique providing a potentially superior cosmetic outcome over conventional laparoscopy. Nevertheless, further advantages offered by this technology are still under discussion and not yet proven. Due to the technically demanding character of the single-site approach, only experienced laparoscopic surgeons should attempt this technique in clinical settings. This work represents the shortened version of the 2013 European Association of Urology guidelines on robotic and single-site surgery. The authors systematically evaluated published evidence in these fields and concluded that robotic assisted surgery is possible and safe for most urologic

  5. The status of invasive pneumococcal disease among children younger than 5 years of age in north-west Lombardy, Italy

    Directory of Open Access Journals (Sweden)

    Riva Enrica

    2012-05-01

    Full Text Available Abstract Background Streptococcus pneumoniae is a leading cause of invasive infection in young children causing morbidity and mortality. Active surveillance systems of invasive pneumococcal disease (IPD are recommended worldwide. The aim of this study was to estimate the current incidence of IPD and to describe the serotype distribution and the antimocrobial susceptibility of S. pneumoniae isolates in children aged less than 5 years residing in North-West Lombardy, Italy. Methods A twelve-month prospective active surveillance system recruited all children aged less than 5 years admitted for suspicion of IPD at emergency room of ten hospitals located in the monitored area. Blood samples were taken in all participants for confirmation of IPD based on isolation of S. pneumoniae from blood. Pneumococcal meningitis and sepsis were additionally confirmed by cerebrospinal fluid analysis. Serotyping and antimicrobial susceptibility testing were performed on isolates from blood. Results A total of 15 confirmed cases of IPD were detected among 135 recruited children, including pneumonia (n = 8, bacteremia (n = 4, sepsis (n = 2 and meningitis (n = 1. The annual IPD incidence rate was 50.0/100,000 (95%CI, 30.5-82.5/100,000. Incidence was 58.3/100,000 (28.8-120.1/100,000 among children aged less than 2 years and 44.4/100,000 (22.9-87.5/100,000 among children aged 2–4 years. Thirteen isolates were typified. The most common serotype was 19A (23.1% that together with serotypes 1, 7F and 19F accounted for 69.2% of typified isolates. Serotypes 14, 23F, 12B and 15C were also identified. The 7- and 13-valent pneumococcal conjugate vaccines covered respectively 30.8% and 84.6% of typified IPD cases. One isolate (serotype 15C was penicillin-resistant and caused meningitis. Conclusions The inclusion of the 13-valent pneumococcal conjugate vaccine in immunization programs of young children might be considered to reduce incidence and morbidity

  6. The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association.

    Science.gov (United States)

    Barry, M J; Fowler, F J; O'Leary, M P; Bruskewitz, R C; Holtgrewe, H L; Mebust, W K; Cockett, A T

    1992-11-01

    A symptom index for benign prostatic hyperplasia (BPH) was developed and validated by a multidisciplinary measurement committee of the American Urological Association (AUA). Validation studies were conducted involving a total of 210 BPH patients and 108 control subjects. The final AUA symptom index includes 7 questions covering frequency, nocturia, weak urinary stream, hesitancy, intermittence, incomplete emptying and urgency. On revalidation, the index was internally consistent (Cronbach's alpha = 0.86) and the score generated had excellent test-retest reliability (r = 0.92). Scores were highly correlated with subjects' global ratings of the magnitude of their urinary problem (r = 0.65 to 0.72) and powerfully discriminated between BPH and control subjects (receiver operating characteristic area 0.85). Finally, the index was sensitive to change, with preoperative scores decreasing from a mean of 17.6 to 7.1 by 4 weeks after prostatectomy (p < 0.001). The AUA symptom index is clinically sensible, reliable, valid and responsive. It is practical for use in practice and for inclusion in research protocols.

  7. Factors influencing scholarly impact: does urology fellowship training affect research output?

    Science.gov (United States)

    Kasabwala, Khushabu; Morton, Christopher M; Svider, Peter F; Nahass, Thomas A; Eloy, Jean Anderson; Jackson-Rosario, Imani

    2014-01-01

    Residents seek postresidency fellowship training to increase competency with novel surgical techniques and augment their fund of knowledge. Research productivity is a vital component of advancement in academic urology. Our objectives were to use the h-index (an objective and readily available bibliometric that has been repeatedly shown to correlate with scholarly impact, funding procurement, and academic promotion in urology as well as other specialties) to determine whether any relationship exists between fellowship training and scholarly impact among academic urologists. Additional examination was performed to determine whether any differences in scholarly influence are present among practitioners in the major urologic subspecialties. Overall, 851 faculty members from 101 academic urology departments were organized by academic rank and fellowship completed. Research productivity was calculated using the h-index, calculated from the Scopus database. There was no statistical difference in h-index found between fellowship-trained and nonfellowship-trained academic urologists. The highest h-indices were seen among urologic oncologists (18.1 ± 0.95) and nonfellowship-trained urologists (14.62 ± 0.80). Nearly 70% of department chairs included in this analysis were urologic oncologists or general urologists. No difference in h-index existed between fellowship-trained and nonfellowship-trained urologists, although practitioners in the subspecialty cohorts with the highest research productivity (nonfellowship-trained and urologic oncologists) comprised 70% of department chairpersons. This relationship suggests that a strong research profile is highly valued during selection for academic promotion. Differences existed on further comparison by subspecialty. Fellowship training may represent another potential opportunity to introduce structured research experiences for trainees. © 2013 Published by Association of Program Directors in Surgery on behalf of Association of

  8. The Timed Up and Go Test as a Measure of Frailty in Urologic Practice.

    Science.gov (United States)

    Pangilinan, Jayce; Quanstrom, Kathryn; Bridge, Mark; Walter, Louise C; Finlayson, Emily; Suskind, Anne M

    2017-08-01

    To evaluate the prevalence of frailty, a known predictor of poor outcomes, among patients presenting to an academic nononcologic urology practice and to examine whether frailty differs among patients who did and did not undergo urologic surgery. The Timed Up and Go Test (TUGT), a parsimonious measure of frailty, was administered to patients ages ≥65. The TUGT, demographic data, urologic diagnoses, and procedural history were abstracted from the medical record into a prospective database. TUGT times were categorized as nonfrail (≤10 seconds), prefrail (11-14 seconds), and frail (≥15 seconds). These times were evaluated across age and urologic diagnoses and compared between patients who did and did not undergo urologic surgery using chi-square and t tests. The TUGT was recorded for 78.9% of patient visits from December 2015 to May 2016. For 1089 patients, average age was 73.3 ± 6.3 years; average TUGT time was 11.6 ± 6.0 seconds; 30.0% were categorized as prefrail and 15.2% as frail. TUGT times increased with age, with 56.9% of patients age 86 and over categorized as frail. Times varied across diagnoses (highest average TUGT was 14.3 ± 11.9 seconds for patients with urinary tract infections); however, no difference existed between patients who did and did not undergo surgery (P = .94). Among our population, prefrailty and frailty were common, TUGT times increased with age and varied by urologic diagnosis, but did not differ between patients who did and did not undergo urologic surgery, presenting an opportunity to consider frailty in preoperative surgical decision making. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. The BLAST View of the Star Forming Region in Aquila (ell=45deg,b=0deg)

    CERN Document Server

    Rivera-Ingraham, Alana; Bock, James J; Chapin, Edward L; Devlin, Mark J; Dicker, Simon R; Griffin, Matthew; Gundersen, Joshua O; Halpern, Mark; Hargrave, Peter C; Hughes, David H; Klein, Jeff; Marsden, Gaelen; Martin, Peter G; Mauskopf, Philip; Netterfield, Calvin B; Olmi, Luca; Patanchon, Guillaume; Rex, Marie; Scott, Douglas; Semisch, Christopher; Truch, Matthew D P; Tucker, Carole; Tucker, Gregory S; Viero, Marco P; Wiebe, Donald V

    2010-01-01

    We have carried out the first general submillimeter analysis of the field towards GRSMC 45.46+0.05, a massive star forming region in Aquila. The deconvolved 6 deg^2 (3\\degree X 2\\degree) maps provided by BLAST in 2005 at 250, 350, and 500 micron were used to perform a preliminary characterization of the clump population previously investigated in the infrared, radio, and molecular maps. Interferometric CORNISH data at 4.8 GHz have also been used to characterize the Ultracompact HII regions (UCHIIRs) within the main clumps. By means of the BLAST maps we have produced an initial census of the submillimeter structures that will be observed by Herschel, several of which are known Infrared Dark Clouds (IRDCs). Our spectral energy distributions of the main clumps in the field, located at ~7 kpc, reveal an active population with temperatures of T~35-40 K and masses of ~10^3 Msun for a dust emissivity index beta=1.5. The clump evolutionary stages range from evolved sources, with extended HII regions and prominent IR ...

  10. ALGORITHM FOR MANAGEMENT OF HYPERTENSIVE PATIENTS UNDERWENT UROLOGY INTERVENTIONS

    Directory of Open Access Journals (Sweden)

    S. S. Davydova

    2015-09-01

    Full Text Available Aim. To study the efficacy of cardiovascular non-invasive complex assessment and pre-operative preparation in hypertensive patients needed in surgical treatment of urology dis- eases.Material and methods. Males (n=883, aged 40 to 80 years were included into the study. The main group consisted of patients that underwent laparotomic nephrectomy (LTN group; n=96 and patients who underwent laparoscopic nephrectomy (LSN group; n=53. Dynamics of ambulatory blood pressure monitoring (ABPM data was analyzed in these groups in the immediate postoperative period. The efficacy of a package of non-invasive methods for cardiovascular system assessment was studied. ABPM was performed after nephrectomy (2-nd and 10-th days after surgery in patients with complaints of vertigo episodes or intense general weakness to correct treatment.Results. In LTN group hypotension episodes or blood pressure (BP elevations were observed in 20 (20.8% and 22 (22.9% patients, respectively, on the 2-nd day after the operation. These complications required antihypertensive treatment correction. Patients with hypotension episodes were significantly older than patients with BP elevation and had significantly lower levels of 24-hour systolic BP, night diastolic BP and minimal night systolic BP. Re-adjustment of antihypertensive treatment on the 10-th postoperative day was required to 2 (10% patients with hypotension episodes and to 1 (4.5% patient with BP elevation. Correction of antihypertensive therapy was required to all patients in LSN group on the day 2, and to 32 (60.4% patients on the 10-th day after the operation. Reduction in the incidence of complications (from 1.2% in 2009 to 0.3% in 2011, p<0.001 was observed during the application of cardiovascular non-invasive complex assessment and preoperative preparation in hypertensive patients.Conclusion. The elaborated management algorithm for patients with concomitant hypertension is recommended to reduce the cardiovascular

  11. Subpubic Cartilaginous Pseudocyst: Orthopedic Feature with Urological Consequences

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    Fawzy Farag

    2014-01-01

    Full Text Available Introduction. Masses arising from structures adjacent to the female urethra can cause obstructive urinary symptoms. Subpubic cartilaginous pseudocyst is a rare degenerative lesion of pubic symphysis that may cause these symptoms. Materials and Methods. A 61-year- and 57-year-old women presented with symptoms of difficult micturition and dyspareunia. Physical examination revealed a painless smooth, rounded, firm, and cystic mass, at the anterior vaginal wall of about 4 cm width. The mass caused inward deviation of the external urethral meatus. Cystoscopy and MRI were done. Results. Cystoscopy of case 1 (61 y demonstrated anterior external urethral compression with normal urethral mucosa. Cystoscopy was not possible in case 2 (57 y because the urethra could not be entered under local anesthesia. MRI showed almost the same findings in both cases: midline, rounded, and cystic mass ~3×3×4 cm, anterosuperior to the urethra, and posteroinferior to the pubic symphysis, with normal features of the urinary bladder. Open surgical excision of theses lesions was performed in both patients. Histopathologic assessment of the specimen obtained from both patients showed degenerated hyaline with areas of fibrinous and mucoid degeneration, a picture suggestive of cartilaginous subpubic pseudocyst. After 11-month and 4-month followup of patients numbers 1 and 2, respectively, there is no evidence of local recurrence of the lesion, either clinically or radiologically and both patients void empty. Conclusions. Subpubic cartilaginous pseudocysts are rare benign lesions with only 13 cases were reported in the literature. Patients present with a spectrum of gynecological and/or urological manifestations. Sizable lesions severely compressing the urethra need surgical excision to restore the voiding function.

  12. Simulators help improve student confidence to acquire skills in urology.

    Science.gov (United States)

    Rodríguez-Díez, M C; Díez, N; Merino, I; Velis, J M; Tienza, A; Robles-García, J E

    2014-01-01

    To know the level of confidence of fifth year medical students in order to perform maneuvers in bladder catheterization and rectal examination before and after training with simulators. To be able to assess student satisfaction regarding the use of the simulation as a learning method. The study was conducted in the Simulation Center of the Faculty of Medicine. A total of 173 students who completed a practical workshop on the subject of Urology participated. The students were asked to answer anonymous questionnaires on their level of confidence in performing a bladder catheterization and rectal examination before and after the workshop as well as their satisfaction in using the simulation as a training tool. The workshops were organized using groups of 10 students. A teacher or a resident in that area of expertise supervised each student individually, resolving their doubts and teaching them the proper technique. All the evaluations made on the different abilities were significantly higher after training (P<.001). Significant differences were found in the confidence level between men and women before the training regarding male urethral catheterization maneuvers and recognition of normal or pathological prostate, The confidence level was lower in women (P<.05). These differences disappeared after training. The level of overall satisfaction with the workshop was high, going from 4.47 ± 0.9 to a maximum score of 5. Simulation is a training method that helps improve the confidence of the medical student in performing a bladder catheterization and digital rectal examination. Copyright © 2013 AEU. Published by Elsevier Espana. All rights reserved.

  13. Managed care and its impact on American urology.

    Science.gov (United States)

    Holtgrewe, H L

    1998-05-01

    America's health care is undergoing a revolution. A previous private, fee-for-service, delivery system chiefly centered around hospital specialty care is rapidly being replaced by a commercialized system of managed care, controlled by businessmen whose prime motive is profit. Increasing emphasis of these managed care organizations is upon primary physicians who function as gatekeepers. While this new commercialized method of health care has been attended with reductions in the previous omnipresent health care inflation our country has experienced for the past several decades, its impact on quality of care and patient choice of physician remain a great concern. Especially vulnerable in this new system are our nation's academic centers, which, burdened with responsibility for education and research, are at a disadvantage in the competitive cost-based bidding for managed care contracts. Urology work force issues and the number of urologists in our nation remain another concern for urologists as they compete for access to patients in this new highly competitive environment. In a 1995 survey of a cohort of urologists in seven states, the respondents reported 35.8% of gross income came from managed care contracts, 86% reported the need for preservice approval for many diagnostic and therapeutic undertakings, 87% reported an inability to refer complex cases outside the Managed Care Organization (MCO) network, and 23% reported they were required to retain patients for treatment who they would have otherwise referred to a more qualified urologist. The majority of American urologists are reporting dropping gross revenues and increasing overhead in their dealings with managed care contracts. The advent of managed care is being attended with dropping gross revenues, increasing overhead costs and interference with the practice patterns of American urologists.

  14. Paediatric urologic pathologies at the national teaching hospital in Cotonou: A etiological and therapeutic aspects

    Directory of Open Access Journals (Sweden)

    Augustin Karl Agossou-Voyeme

    2013-01-01

    Full Text Available Background: Urological pathologies of children are dominated by congenital malformations of the kidneys and urinary tract. Their management is often surgical. The objective of this survey was to study etiological and therapeutic aspects of urological presentations in children. Patients and Methods: Data for aetiology, treatment, and results in children hospitalized at the Paediatric Surgery service of National Teaching Hospital (CNHU in Cotonou were retrospectively analyzed from January 1999 to December 2008. Results: A total of 214 patients with complete data were evaluated. Urological pathologies represented 4.8% of the hospitalizations in paediatric surgery, with an incidence of 21 cases per year. The mean age was 4.9 ± 3.2 years (age 1 week to 14 years. The male to female ratio was 14:14. Cryptorchidism, hydrocele, nephroblastoma, the posterior urethral valves, ureteropelvic junction obstructions, post-circumcision haemorrhage and hypospadias were the most frequent pathologies. Congenital urological malformations represented 81.3%, followed neoplastic pathologies (7.9%, traumatic pathologies (6.1% and others (4.7%. The disorders of male genitalia were more frequent and constituted 68.2% of the cases. The anomalies of the urinary tract were 30.8% and intersex disorders were 0.9%. The average age of the children urological pathologies at the time of consultation was 8.85 ± 4.6 years. The treatment was often surgical with a mortality of 2.8%.

  15. Robot-assisted urologic surgery in 2010 - Advancements and future outlook

    Directory of Open Access Journals (Sweden)

    Paurush Babbar

    2011-01-01

    Full Text Available Robotic surgery is a cutting edge and minimally invasive procedure, which has generated a great deal of excitement in the urologic community. While there has been much advancement in this emerging technology, it is safe to say that robotic urologic surgery holds tremendous potential for progress in the near future. Hence, it is paramount that urologists stay up-to-date regarding new developments in the realm of robotics with respect to novel applications, limitations and opportunities for incorporation into their practice. Robot-assisted surgery provides an enhanced 3D view, increased magnification of the surgical field, better manual dexterity, relatively bloodless field, elimination of surgeon′s tremor, reduction in a surgeon′s fatigue and mitigation of scattered light. All these factors translate into greater precision of surgical dissection, which is imperative in providing better intraoperative and postoperative outcomes. Pioneering work assessing the feasibility of robotic surgery in urology began in the early 2000′s with robot-assisted radical prostatectomy and has since expanded to procedures such as robot-assisted radical cystectomy, robot-assisted partial nephrectomy, robot-assisted nephroureterectomy and robot-assisted pyeloplasty. A MEDLINE search was used to identify recent articles (within the last two years and publications of specific importance, which highlighted the recent developments and future direction of robotics. This review will use the aforementioned urologic surgeries as vehicles to evaluate the current status and future role of robotics in the advancement of the field of urology.

  16. Expert Involvement Predicts mHealth App Downloads: Multivariate Regression Analysis of Urology Apps.

    Science.gov (United States)

    Pereira-Azevedo, Nuno; Osório, Luís; Cavadas, Vitor; Fraga, Avelino; Carrasquinho, Eduardo; Cardoso de Oliveira, Eduardo; Castelo-Branco, Miguel; Roobol, Monique J

    2016-07-15

    Urological mobile medical (mHealth) apps are gaining popularity with both clinicians and patients. mHealth is a rapidly evolving and heterogeneous field, with some urology apps being downloaded over 10,000 times and others not at all. The factors that contribute to medical app downloads have yet to be identified, including the hypothetical influence of expert involvement in app development. The objective of our study was to identify predictors of the number of urology app downloads. We reviewed urology apps available in the Google Play Store and collected publicly available data. Multivariate ordinal logistic regression evaluated the effect of publicly available app variables on the number of apps being downloaded. Of 129 urology apps eligible for study, only 2 (1.6%) had >10,000 downloads, with half having ≤100 downloads and 4 (3.1%) having none at all. Apps developed with expert urologist involvement (P=.003), optional in-app purchases (P=.01), higher user rating (PApp cost was inversely related to the number of downloads (Papp development is likely to enhance its chances to have a higher number of downloads. This finding should help in the design of better apps and further promote urologist involvement in mHealth. Official certification processes are required to ensure app quality and user safety.

  17. Robot-assisted urologic surgery in 2010 – Advancements and future outlook

    Science.gov (United States)

    Babbar, Paurush; Hemal, Ashok K

    2011-01-01

    Robotic surgery is a cutting edge and minimally invasive procedure, which has generated a great deal of excitement in the urologic community. While there has been much advancement in this emerging technology, it is safe to say that robotic urologic surgery holds tremendous potential for progress in the near future. Hence, it is paramount that urologists stay up-to-date regarding new developments in the realm of robotics with respect to novel applications, limitations and opportunities for incorporation into their practice. Robot-assisted surgery provides an enhanced 3D view, increased magnification of the surgical field, better manual dexterity, relatively bloodless field, elimination of surgeon′s tremor, reduction in a surgeon′s fatigue and mitigation of scattered light. All these factors translate into greater precision of surgical dissection, which is imperative in providing better intraoperative and postoperative outcomes. Pioneering work assessing the feasibility of robotic surgery in urology began in the early 2000's with robot-assisted radical prostatectomy and has since expanded to procedures such as robot-assisted radical cystectomy, robot-assisted partial nephrectomy, robot-assisted nephroureterectomy and robot-assisted pyeloplasty. A MEDLINE search was used to identify recent articles (within the last two years) and publications of specific importance, which highlighted the recent developments and future direction of robotics. This review will use the aforementioned urologic surgeries as vehicles to evaluate the current status and future role of robotics in the advancement of the field of urology. PMID:21346825

  18. Photoluminescence of a High Mobility 2DEG in the Fractional Quantum Hall Effect Regime

    Science.gov (United States)

    Smirnov, D.; Rudenkov, V. V.; Ashkinadze, B. M.; Cohen, E.; Christianen, P. C. M.; Maan, J. C.; Pfeiffer, L. N.

    The magneto-PL spectra of modulation-doped, ultra-high mobility GaAs/AlGaAs single heterojunctions (HJs) were studied under a perpendicularly applied magnetic field up to 33 T and at temperatures of 0.3 and 1.2 K. The spectra show remarkable intensity redistribution between free (bulk) exciton and 2DEG-hole PL channels occurring at electron filling factors, ν = 2 and 1. At 0.3 K, significant 2DEG-hole PL spectral changes are observed near ν = 2/3 and 1/3. Several heterojunctions with 2DEG density in the range of n2D - (1 - 2.7) · 1011 cm-2 display similar features. These spectral peculiarities are attributed to the modification of the 2DEG energy spectrum caused by the e-e interaction, in particular, the recombination of valence hole with the composite (fractionally-charged) particles of the magnetized 2DEG. In HJs with lower n2D < 1011 cm-2, the observed PL evolution at ν < 1 is mainly determined by an intensity redistribution between the σ+ and σ- circularly-polarized free exciton PL components. In this case, the exciton energy is lower than the energy of the 2DEG-hole system, so that the free excitons do not dissociate near the magnetized 2DEG and thus, the 2DEG-hole PL is barely observed.

  19. Accelerated transformation of brushite to octacalcium phosphate in new biomineralization media between 36.5 deg. C and 80 deg. C

    Energy Technology Data Exchange (ETDEWEB)

    Temizel, Neslihan; Girisken, Giray; Tas, A. Cuneyt, E-mail: cuneyt-tas@ouhsc.edu

    2011-07-20

    This study investigated the hydrothermal transformation of brushite (dicalcium phosphate dihydrate, DCPD, CaHPO{sub 4}.2H{sub 2}O) into octacalcium phosphate (OCP, Ca{sub 8}(HPO{sub 4}){sub 2}(PO{sub 4}){sub 4}.5H{sub 2}O) in seven different newly developed biomineralization media, all inspired from the commercial DMEM solutions, over the temperature range of 36.5 deg. C to 90 deg. C with aging times varying between 1 h and 6 days. DCPD powders used in this study were synthesized in our laboratory by using a wet-chemical technique. DCPD was found to transform into OCP in the Ca{sup 2+}, Mg{sup 2+}, Na{sup +}, K{sup +}, HCO{sub 3}{sup -}, Cl{sup -} and H{sub 2}PO{sub 4}{sup -} containing aqueous biomineralization media in less than 72 h at 36.5 deg. C, without stirring. The same medium was able to convert DCPD into OCP in about 2 h at 75-80 deg. C, again without a need for stirring. Samples were characterized by using powder X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). - Research highlights: {yields} New biomineralization solutions developed to convert DCPD into OCP at 36.5 deg. C to 80 deg. C. {yields} DCPD powder was the starting material. {yields} OCP was synthesized under static conditions (no need for stirring). {yields} OCP was synthesized in sealed glass media bottles in solutions free of Hepes or Tris. {yields} OCP can be synthesized at 75-80 deg. C in only 2 hours in the above solutions without stirring.

  20. Flexure fatigue testing of 90 deg graphite/epoxy composites

    Science.gov (United States)

    Peck, Ann Nancy W.

    1995-01-01

    3-point flexure tests of 90 deg graphite/epoxy specimens. Investigations will include the volume scale effect as well as frequency and span-to-thickness ratio effects. Prior to the start of the experimental study, an analytical study using finite element modeling will be performed to investigate the span-to-thickness effect. The ratio of transverse flexure stress to shear stress will be monitored and its values predicted by the FEM analysis compared with the value obtained using a 'strength of materials' based approach.

  1. AtDeg2 – a chloroplast protein with dual protease/chaperone activity

    Directory of Open Access Journals (Sweden)

    Przemysław Jagodzik

    2014-07-01

    Full Text Available Chloroplast protease AtDeg2 (an ATP-independent serine endopeptidase is cytosolically synthesized as a precursor, which is imported into the chloroplast stroma and deprived of its transit peptide. Then the mature protein undergoes routing to its functional location at the stromal side of thylakoid membrane. In its linear structure AtDeg2 molecule contains the protease domain with catalytic triad (HDS and two PDZ domains (PDZ1 and PDZ2. In vivo AtDeg2 most probably exists as a supposedly inactive haxamer, which may change its oligomeric stage to form active 12-mer, or 24-mer. AtDeg2 has recently been demonstrated to exhibit dual protease/chaperone function. This review is focused on the current awareness with regard to AtDeg2 structure and functional significance.

  2. Patologie sociali, resistenze e difese degli insegnanti nell’istituzione scolastica: Considerazioni cliniche e pedagogiche

    Directory of Open Access Journals (Sweden)

    Tommaso Fratini

    2014-12-01

    Full Text Available L’articolo prende in esame il tema di alcune resistenze e difese degli insegnanti all’interno dell’istituzione scolastica. Partendo dall’attuale condizione di emergenza della scuola italiana e rifacendosi al concetto di patologia sociale di Giuseppe Di Chiara, viene argomentato come tali resistenze coprano le angosce persecutorie degli insegnanti nel loro lavoro scolastico quotidiano nel rapporto con gli allievi. L’articolo, tra le varie forme di patologia istituzionale, affronta principalmente il tema di quelle che presiedono alle resistenze degli insegnanti al lavoro introspettivo con il proprio mondo interno, conseguenza e ulteriore cagione di sensi di colpa nel rapporto con gli allievi e di fenomeni di burnout lavorativo degli stessi insegnanti. Tali fenomeni vanno nella direzione del rinforzo sia di un atteggiamento di chiusura verso la collaborazione con professionisti esterni all’istituzione scolastica, sia di un atteggiamento di minore empatia e vicinanza emotiva con la realtà interna degli allievi.

  3. Temperature dependent dynamics of DegP-trimer: A molecular dynamics study.

    Science.gov (United States)

    Rai, Nivedita; Ramaswamy, Amutha

    2015-01-01

    DegP is a heat shock protein from high temperature requirement protease A family, which reacts to the environmental stress conditions in an ATP independent way. The objective of the present analysis emerged from the temperature dependent functional diversity of DegP between chaperonic and protease activities at temperatures below and above 28 °C, respectively. DegP is a multimeric protein and the minimal functional unit, DegP-trimer, is of great importance in understanding the DegP pathway. The structural aspects of DegP-trimer with respect to temperature variation have been studied using molecular dynamics simulations (for 100 ns) and principal component analysis to highlight the temperature dependent dynamics facilitating its functional diversity. The DegP-trimer revealed a pronounced dynamics at both 280 and 320 K, when compared to the dynamics observed at 300 K. The LA loop is identified as the highly flexible region during dynamics and at extreme temperatures, the residues 46-80 of LA loop express a flip towards right (at 280) and left ( at 320 K) with respect to the fixed β-sheet connecting the LA loop of protease for which Phe46 acts as one of the key residues. Such dynamics of LA loop facilitates inter-monomeric interaction with the PDZ1 domain of the neighbouring monomer and explains its active participation when DegP exists as trimer. Hence, the LA loop mediated dynamics of DegP-trimer is expected to provide further insight into the temperature dependent dynamics of DegP towards the understanding of its assembly and functional diversity in the presence of substrate.

  4. Temperature dependent dynamics of DegP-trimer: A molecular dynamics study

    Directory of Open Access Journals (Sweden)

    Nivedita Rai

    2015-01-01

    Full Text Available DegP is a heat shock protein from high temperature requirement protease A family, which reacts to the environmental stress conditions in an ATP independent way. The objective of the present analysis emerged from the temperature dependent functional diversity of DegP between chaperonic and protease activities at temperatures below and above 28 °C, respectively. DegP is a multimeric protein and the minimal functional unit, DegP-trimer, is of great importance in understanding the DegP pathway. The structural aspects of DegP-trimer with respect to temperature variation have been studied using molecular dynamics simulations (for 100 ns and principal component analysis to highlight the temperature dependent dynamics facilitating its functional diversity. The DegP-trimer revealed a pronounced dynamics at both 280 and 320 K, when compared to the dynamics observed at 300 K. The LA loop is identified as the highly flexible region during dynamics and at extreme temperatures, the residues 46–80 of LA loop express a flip towards right (at 280 and left ( at 320 K with respect to the fixed β-sheet connecting the LA loop of protease for which Phe46 acts as one of the key residues. Such dynamics of LA loop facilitates inter-monomeric interaction with the PDZ1 domain of the neighbouring monomer and explains its active participation when DegP exists as trimer. Hence, the LA loop mediated dynamics of DegP-trimer is expected to provide further insight into the temperature dependent dynamics of DegP towards the understanding of its assembly and functional diversity in the presence of substrate.

  5. Nobel Prize nominees and the rise of urology in Europe around 1900.

    Science.gov (United States)

    Hansson, Nils; Krischel, Matthis; Halling, Thorsten; Moll, Friedrich; Fangerau, Heiner

    2017-08-01

    Recent historical research has reconstructed the roads leading to the Nobel Prize for the trained urologists Werner Forssmann (1904-1979) in 1956 and Charles Huggins (1901-1997) in 1966. However, the story of urology and the Nobel Prize does not start and end with the laureates. Taking James Israel (1848-1926), Félix Guyon (1831-1920), and Peter J Freyer (1852-1921) as examples, this paper shows that pioneers in urology were in fact runners-up for the award much earlier. The study is based on an analysis of original files in the Nobel Prize archive in Stockholm, scientific publications of the early twentieth century, and secondary literature. We argue that Israel's, Guyon's, and Freyer's candidacies reflect not only scientific trends and controversies in urology at the turn of twentieth century, but that the development of the specialty itself was reflected in nominations of physicians working on problems of the genito-urinary system.

  6. A Review of Transplantation Practice of the Urologic Organs: Is It Only Achievable for the Kidney?

    Science.gov (United States)

    Donati-Bourne, Jack; Roberts, Harry W; Rajjoub, Yaseen; Coleman, Robert A

    2015-01-01

    Transplantation is a viable treatment option for failure of most major organs. Within urology, transplantation of the kidney and ureter are well documented; however, evidence supporting transplantation of other urologic organs is limited. Failure of these organs carries significant morbidity, and transplantation may have a role in management. This article reviews the knowledge, research, and literature surrounding transplantation of each of the urologic organs. Transplantation of the penis, testicle, urethra, vas deferens, and bladder is discussed. Transplantation attempts have been made individually with each of these organs. Penile transplantation has only been performed once in a human. Testicular transplantation research was intertwined with unethical lucrative pursuits. Interest in urethra, bladder, and vas deferens transplantation has decreased as a result of successful surgical reconstructive techniques. Despite years of effort, transplantations of the penis, testicle, urethra, vas deferens, and bladder are not established in current practice. Recent research has shifted toward techniques of reconstruction, tissue engineering, and regenerative medicine.

  7. [Economic profitability: current aspects of X-ray contrast diagnosis in urology].

    Science.gov (United States)

    Ukolov, V A; Perepanova, T S; Grigor'ev, A A

    2005-01-01

    A diversity of X-ray contrast diagnostic techniques used in urology provides a way of using different groups of X-ray contrast materials (XCMs) in accordance of the set tasks. Many years' experience in handling water-soluble triiodinated XCMs while examining the kidneys and urinary tract provides evidence for their diagnostic effectiveness and safety. The new Triombrast (OAO "Farmac", Kiev) synthesized on the basis of the Spanish substance (Justesa Imagen SA) has successfully undergone clinical trials and meets the high requirements made by the specialized urological facilities is economically profitable. The paper has been prepared, by using the reports on the results of preclinical studies of the agent and the experience of its use in the clinic of the Research Institute of Urology and City Clinical Hospital No. 47, Moscow.

  8. [The biography of Maximilian Nitze (1848-1906) and his contribution to the urology].

    Science.gov (United States)

    Verger-Kuhnke, A B; Beccaría, M L

    2007-01-01

    Maximilian Carl Friedrich Nitze was born on the 18 of September of 1848 in Berlin the capital of Prussia. 1869 while still being a Student of the Heidelberg University the first nephrectomy of the world performed by Gustav Simon (1824-1876) woke his interest in urology. 1874 by the age of 26 he passed his state examination and obtained a doctor degree in medicine. On the 2 October of 1877 he presented the first cystoscope to the members of the Real Medical School in Dresden. Nitzes doubtless valuable contribution to urology was making real the endoscopical exploration of the genitourinary system and initializing the era of surgical treatments under direct vision. By the beginning of the XX century urology reached the status of an independent specialty by separating from surgery, dermatology/venerology, internal medicine and pathology.

  9. Detection and Isolation of Circulating Tumor Cells in Urologic Cancers: A Review

    Directory of Open Access Journals (Sweden)

    Robert D. Loberg

    2004-07-01

    Full Text Available The American Cancer Society has estimated that in 2003, there will be approximately 239,600 new cases of urologic cancer diagnosed and 54,600 urologic cancer-related deaths in the United States. To date, the majority of research and therapy design have focused on the microenvironment of the primary tumor site, as well as the microenvironment of the metastatic or secondary (target tumor site. Little attention has been placed on the interactions of the circulating tumor cells and the microenvironment of the circulation (i.e., the third microenvironment. The purpose of this review is to present the methods for the detection and isolation of circulating tumor cells and to discuss the importance of circulating tumor cells in the biology and treatment of urologic cancers.

  10. Hospital Episode Statistics data analysis of postoperative venous thromboembolus in patients undergoing urological surgery: a review of 126,891 cases

    NARCIS (Netherlands)

    Dyer, J.; Wyke, S.; Lynch, C.

    2013-01-01

    INTRODUCTION: Current guidelines on venous thromboembolism (VTE) prevention do not reflect the potential varying risk for patients undergoing different urological procedures. Our study aimed to establish the procedure specific rate of postoperative VTE in patients undergoing urological surgery. METH

  11. From Leonardo to da Vinci: the history of robot-assisted surgery in urology.

    Science.gov (United States)

    Yates, David R; Vaessen, Christophe; Roupret, Morgan

    2011-12-01

    What's known on the subject? and What does the study add? Numerous urological procedures can now be performed with robotic assistance. Though not definitely proven to be superior to conventional laparoscopy or traditional open surgery in the setting of a randomised trial, in experienced centres robot-assisted surgery allows for excellent surgical outcomes and is a valuable tool to augment modern surgical practice. Our review highlights the depth of history that underpins the robotic surgical platform we utilise today, whilst also detailing the current place of robot-assisted surgery in urology in 2011. The evolution of robots in general and as platforms to augment surgical practice is an intriguing story that spans cultures, continents and centuries. A timeline from Yan Shi (1023-957 bc), Archytas of Tarentum (400 bc), Aristotle (322 bc), Heron of Alexandria (10-70 ad), Leonardo da Vinci (1495), the Industrial Revolution (1790), 'telepresence' (1950) and to the da Vinci(®) Surgical System (1999), shows the incredible depth of history and development that underpins the modern surgical robot we use to treat our patients. Robot-assisted surgery is now well-established in Urology and although not currently regarded as a 'gold standard' approach for any urological procedure, it is being increasingly used for index operations of the prostate, kidney and bladder. We perceive that robotic evolution will continue infinitely, securing the place of robots in the history of Urological surgery. Herein, we detail the history of robots in general, in surgery and in Urology, highlighting the current place of robot-assisted surgery in radical prostatectomy, partial nephrectomy, pyeloplasty and radical cystectomy.

  12. Ex vivo applications of multiphoton microscopy in urology

    Science.gov (United States)

    Jain, Manu; Mukherjee, Sushmita

    2016-03-01

    Background: Routine urological surgery frequently requires rapid on-site histopathological tissue evaluation either during biopsy or intra-operative procedure. However, resected tissue needs to undergo processing, which is not only time consuming but may also create artifacts hindering real-time tissue assessment. Likewise, pathologist often relies on several ancillary methods, in addition to H&E to arrive at a definitive diagnosis. Although, helpful these techniques are tedious and time consuming and often show overlapping results. Therefore, there is a need for an imaging tool that can rapidly assess tissue in real-time at cellular level. Multiphoton microscopy (MPM) is one such technique that can generate histology-quality images from fresh and fixed tissue solely based on their intrinsic autofluorescence emission, without the need for tissue processing or staining. Design: Fresh tissue sections (neoplastic and non-neoplastic) from biopsy and surgical specimens of bladder and kidney were obtained. Unstained deparaffinized slides from biopsy of medical kidney disease and oncocytic renal neoplasms were also obtained. MPM images were acquired using with an Olympus FluoView FV1000MPE system. After imaging, fresh tissues were submitted for routine histopathology. Results: Based on the architectural and cellular details of the tissue, MPM could characterize normal components of bladder and kidney. Neoplastic tissue could be differentiated from non-neoplastic tissue and could be further classified as per histopathological convention. Some of the tumors had unique MPM signatures not otherwise seen on H&E sections. Various subtypes of glomerular lesions were identified as well as renal oncocytic neoplasms were differentiated on unstained deparaffinized slides. Conclusions: We envision MPM to become an integral part of regular diagnostic workflow for rapid assessment of tissue. MPM can be used to evaluate the adequacy of biopsies and triage tissues for ancillary studies

  13. Urological complications after radical hysterectomy: Incidence rates and predisposing factors

    Directory of Open Access Journals (Sweden)

    Likić-Lađević Ivana

    2007-01-01

    Full Text Available Bacground/Aim. Radical hysterectomy is a surgical approach for stage Ib and IIa of cervical cancer. The incidence of intraoperative injuries of the bladder during radical hysterectomy ranges from 0.4-3.7%. The ureter can be crushed, caught in sutures, transsected, obstructed by angulation, or ischemic by the stippling or periureteric fascia. Vesicovaginal and ureterovaginal fistuls are reported to develop in 0.9-2% of patients after radical abdominal hysterectomy. Fistulas usually become manifested or visible at speculum examination within 14 days following the surgery. The aim of this study was to establish the incidence and predisposing factor of urological complications after radical hysterectomy. Methods. The study included a total of 536 patients with invasive stage Ib to IIb cancer of the cervix uteri who had underwent radical hysterectomy. The special elements considered were: the patient’s age; the International Federation of Ginecology and Obstetrics (FIGO stage after pathohistology; duration of operation; the result of preoperative laboratory tests for diabetes, anemia, hypoproteinemia, or disorders of liver or kidney function; ASA status; postoperative surgical infection. Results. The average age of the patients with complications was 48.68 years. All patients with intraoperative ureteric and bladder injuries had statisticaly significant higher stage of disease and operation lasted more than in others without injury. We noticed 1.3% ureteral injuries and 1.49% bladder injuries, more than 50% of the patients with a previously mentioned injuries were operated on more than 3 hours. We found 2.61% vesicovaginal and 2.43% ureterovaginal fistuls. A total of 50% of the patients with bladder injury and vesicovaginal fistuls and 70% of the patients with ureterovaginal fistuls had diabetes mellitus. Postoperative infection of surgical site is a very important factor for the development of fistule. Half of the patients with vesicovaginal

  14. Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations

    NARCIS (Netherlands)

    Trpkov, K.; Grignon, D.J.; Bonsib, S.M.; Amin, M.B.; Billis, A.; Lopez-Beltran, A.; Samaratunga, H.; Tamboli, P.; Delahunt, B.; Egevad, L.; Montironi, R.; Srigley, J.R.; Hulsbergen-van de Kaa, C.A.

    2013-01-01

    The International Society of Urologic Pathology 2012 Consensus Conference on renal cancer, through working group 3, focused on the issues of staging and specimen handling of renal tumors. The conference was preceded by an online survey of the International Society of Urologic Pathology members, and

  15. Multiple authorship and article type in journals of urology across the Atlantic: trends over the past six decades.

    Science.gov (United States)

    Hammad, Fayez T; Shaban, Sami; Abu-Zidan, Fikri

    2012-01-01

    The aim of this research was to study the trends in authorship and type of article in European and North American journals of urology over the past 6 decades. Using a self-developed Visual Basic program, the number of authors per article and the type of article in four European journals (BJU International, Current Opinion in Urology, European Urology and Urologia Internationalis) and four North American journals (Journal of Urology, Urologic Clinics of North America, Urology and World Journal of Urology) were extracted from the PubMed website from January 1946 to October 2010, and the number of authors per article in each year was calculated in all the journals. The average number of authors per article has increased and the percentage of single-author articles has decreased in both European and American journals. An increase in the number of authors per article was observed mainly in original articles and case reports. Since the early 1980s, there has also been a decreasing percentage of published case reports and a general increase in the percentage of letters to the editor and editorials. The multiple-authorship trends observed in both European and North American urology journals were similar and appeared to be mainly due to changes in original articles and case reports. Copyright © 2012 S. Karger AG, Basel.

  16. Evaluation of urologic morbidity after radiotherapy for cervical carcinoma by urodynamic examinations and patient voiding schemes: a prospective study

    DEFF Research Database (Denmark)

    Lajer, Henrik; Thranov, Ingrid R; Bagi, Per;

    2002-01-01

    To assess urologic morbidity in a 5-year period by urodynamic examinations and patient voiding schemes after radiotherapy and brachytherapy for cervical carcinoma.......To assess urologic morbidity in a 5-year period by urodynamic examinations and patient voiding schemes after radiotherapy and brachytherapy for cervical carcinoma....

  17. Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations

    NARCIS (Netherlands)

    Trpkov, K.; Grignon, D.J.; Bonsib, S.M.; Amin, M.B.; Billis, A.; Lopez-Beltran, A.; Samaratunga, H.; Tamboli, P.; Delahunt, B.; Egevad, L.; Montironi, R.; Srigley, J.R.; Hulsbergen-van de Kaa, C.A.

    2013-01-01

    The International Society of Urologic Pathology 2012 Consensus Conference on renal cancer, through working group 3, focused on the issues of staging and specimen handling of renal tumors. The conference was preceded by an online survey of the International Society of Urologic Pathology members, and

  18. 78 FR 41937 - Joint Meeting of the Gastroenterology-Urology Panel and the Radiological Devices Panel of the...

    Science.gov (United States)

    2013-07-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Joint Meeting of the Gastroenterology-Urology Panel and the... the public. Name of Committee: Gastroenterology-Urology Panel and Radiological Devices Panel of...

  19. Training potential in minimally invasive surgery in a tertiary care, paediatric urology centre.

    Science.gov (United States)

    Schroeder, R P J; Chrzan, R J; Klijn, A J; Kuijper, C F; Dik, P; de Jong, T P V M

    2015-10-01

    Minimally invasive surgery (MIS) is being utilized more frequently as a surgical technique in general surgery and in paediatric urology. It is associated with a steep learning curve. Currently, the centre does not offer a MIS training programme. It is hypothesized that the number of MIS procedures performed in the low-volume specialty of paediatric urology will offer insufficient training potential for surgeons. To assess the MIS training potential of a highly specialized, tertiary care, paediatric urology training centre that has been accredited by the Joint Committee of Paediatric Urology (JCPU). The clinical activity of the department was retrospectively reviewed by extracting the annual number of admissions, outpatient consultations and operative procedures. The operations were divided into open procedures and MIS. Major ablative procedures (nephrectomy) and reconstructive procedures (pyeloplasty) were analysed with reference to the patients' ages. The centre policy is not to perform major MIS in children who are under 2 years old or who weigh less than 12 kg. Every year, this institution provides approximately 4300 out-patient consultations, 600 admissions, and 1300 procedures under general anaesthesia for children with urological problems. In 2012, 35 patients underwent major intricate MIS: 16 pyeloplasties, eight nephrectomies and 11 operations for incontinence (seven Burch, and four bladder neck procedures). In children ≥2 years of age, 16/21 of the pyeloplasties and 8/12 of the nephrectomies were performed laparoscopically. The remaining MIS procedures included 25 orchidopexies and one intravesical ureteral reimplantation. There is no consensus on how to assess laparoscopic training. It would be valuable to reach a consensus on a standardized laparoscopic training programme in paediatric urology. Often training potential is based on operation numbers only. In paediatric urology no minimum requirement has been specified. The number of procedures quoted

  20. Nefro-urological mortality causes in Jerez de los Caballeros (Badajoz) in the nineteenth century.

    Science.gov (United States)

    Peral, D; Suárez-Guzmán, F J

    2014-11-01

    The causes of mortality from nefro-urologic diseases in Jerez de los Caballeros (Badajoz) during the nineteenth century will be our object of study. We have analyzed the death registry books of the parishes in Jerez. The percentage of deaths from nefro-urologic diseases compared to other pathologies is 0.8%, being most affected males in age ranges from 25-34 and 65-75 years of age. The months with the highest mortality were July, December and January. Due to the deficient death registrations in the first decades of the century, the results should be taken with caution.

  1. [Comparative study of two protocols of antibiotic prophylaxis in endoscopic urologic surgery].

    Science.gov (United States)

    Lepage, J Y; Malinowsky, J M; Cozian, A; Viers, M F; Rolland, M T; Péron, M; Souron, R; Baron, D

    1990-06-01

    We report an open, prospective, randomized and double-blind study which compared two groups of patients without preoperative bacteriuria, undergoing transurethral urologic surgery. A first group received cefazoline 3 g perioperatively and a second group a single preoperative dose of cefotiam 1 g. A hundred patients were included in each group which were well matched on all essential characteristics, risk factors, surgery, anesthesia and postoperative temperature. The incidence of postoperative infection (bacteriemia and bacteriuria) was the same in both groups (16%). It is concluded that in transurethral urologic surgery performed in patients without preoperative bacteriuria, 1 preoperative dose cefotiam is as efficacious as 3 perioperative doses cefazoline.

  2. Anticipating the effect of the Patient Protection and Affordable Care Act for patients with urologic cancer.

    Science.gov (United States)

    Ellimoottil, Chandy; Miller, David C

    2014-02-01

    The Affordable Care Act seeks to overhaul the US health care system by providing insurance for more Americans, improving the quality of health care delivery, and reducing health care expenditures. Although the law's intent is clear, its implementation and effect on patient care remains largely undefined. Herein, we discuss major components of the Affordable Care Act, including the proposed insurance expansion, payment and delivery system reforms (e.g., bundled payments and Accountable Care Organizations), and other reforms relevant to the field of urologic oncology. We also discuss how these proposed reforms may affect patients with urologic cancers.

  3. The impact of nuclear imaging on pediatric urology; Die Bedeutung nuklearmedizinischer Untersuchungsverfahren in der Kinderurologie

    Energy Technology Data Exchange (ETDEWEB)

    Zoeller, G. [Urologische Universitaetsklinik, Goettingen (Germany)

    2000-11-01

    Nuclear imaging has a key role in diagnosis and therapy in modern pediatric urology. We discuss the value and limitations of radionuclide studies (diuresis renogramm, DMSA, VCUG, MIBG scintigraphy) with special regard to characteristic pathologic entities in pediatric urology. (orig.) [German] Nuklearmedizinische Untersuchungsverfahren nehmen in der modernen Kinderurologie eine zentrale Stellung in der Diagnostik und Therapieplanung ein. In einer Uebersicht werden die Wertigkeit der verschiedenen Untersuchungsverfahren (Diureserenographie, DMSA, Isotopen-MCU, MIBG-Szintigraphie) bei typischen kinderurologischen Krankheitsbildern dargestellt und ihre Grenzen aufgezeigt. (orig.)

  4. Advances in laparoscopic urologic surgery techniques [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Haidar M. Abdul-Muhsin

    2016-04-01

    Full Text Available The last two decades witnessed the inception and exponential implementation of key technological advancements in laparoscopic urology. While some of these technologies thrived and became part of daily practice, others are still hindered by major challenges. This review was conducted through a comprehensive literature search in order to highlight some of the most promising technologies in laparoscopic visualization, augmented reality, and insufflation. Additionally, this review will provide an update regarding the current status of single-site and natural orifice surgery in urology.

  5. Infrequent Reservoir‐Related Complications of Urologic Prosthetics: A Case Series and Literature Review

    Directory of Open Access Journals (Sweden)

    Tao Cui, MD

    2015-12-01

    Conclusion: Complications involving urologic prosthesis reservoirs, although rare, can have serious implications for patients. A high index of suspicion and familiarity with treatment options is required in order to allow timely diagnosis and appropriate treatment. Patients with prior major abdominal surgeries seem to be more prone to intestinal complications of reservoirs and warrant special concern. Cui T, Terlecki R, and Mirzazadeh M. Infrequent reservoir‐related complications of urologic prosthetics: A case series and literature review. Sex Med 2015;3:334–338.

  6. Classics of urology: a half century history of the most frequently cited articles (1955-2009).

    Science.gov (United States)

    Heldwein, Flavio Lobo; Rhoden, Ernani Luis; Morgentaler, Abraham

    2010-06-01

    To identify and characterize the most frequently cited articles published in Journals dedicated to Urology over the last 50 years. A Pubmed search was performed of all articles published in the 13 most cited urological journals between 1955 and 2009. Articles with more than 100 citations were identified as "classic", and were analyzed further. Of 97,554 articles published during this time, 1239 articles were cited more than 100 times. The most common topic among classic articles was prostate cancer and prostate-specific antigen (33.5%), followed by bladder cancer and benign prostatic hyperplasia. A further analysis was performed for the 50 most frequently cited articles ("top-50").

  7. Food and Drug Administration process for development and approval of drugs and radiopharmaceuticals: treatments in urologic oncology.

    Science.gov (United States)

    Ning, Yang-Min; Maher, V Ellen

    2015-03-01

    Regulatory advice and assessment play an important role in the successful development of new drugs and radiopharmaceuticals for the treatment of urologic malignancies. Cooperation between the US Food and Drug Administration (FDA) and the pharmaceutical industry has led to the approval of more than 20 new urologic oncology products in the last 2 decades. Despite these advances, more effective treatments need to be developed and approved for the treatment of urologic malignancies. This review provides general information about the FDA's role in the development of investigational new drugs, with an emphasis on the regulatory process and the requirements for marketing approval. In addition, this review summarizes the products for the treatment of urologic malignancies that were approved by the FDA in the last 30 years and the key issues concerning urologic oncology products that were discussed publicly at Oncologic Drug Advisory Committee meetings in the past 10 years.

  8. Using Paraffin with -10 deg C to 10 deg C Melting Point for Payload Thermal Energy Storage in SpaceX Dragon Trunk

    Science.gov (United States)

    Choi, Michael K.

    2013-01-01

    A concept of using paraffin wax phase change material (PCM) with a melting point between -10 deg C and 10 deg C for payload thermal energy storage in a Space Exploration Technologies (SpaceX) Dragon trunk is presented. It overcomes the problem of limited heater power available to a payload with significant radiators when the Dragon is berthed to the International Space Station (ISS). It stores adequate thermal energy to keep a payload warm without power for 6 hours during the transfer from the Dragon to an ExPRESS logistics carrier (ELC) on the ISS.

  9. Far-infrared and submillimeter survey of the galactic plane from l = 11.5 deg to l = 17.5 deg

    Science.gov (United States)

    Campbell, M. F.; Niles, D. W.; Silverberg, R. F.; Hauser, M. G.; Stier, M. T.; Kelsall, T.; Hoffmann, W. F.; Thronson, H. A., Jr.

    1984-01-01

    Medium resolution (11 min) maps of the galactic plane are presented from l = 11.5 deg to l = 17.5 deg at wavelengths of 93 microns, 154 microns, and 190 microns. The maps are interpreted in terms of the temperature and spatial structure of diffuse far-infrared/submillimeter sources associated with evolved H II regions and a continuous ridge of galactic emission. The emission regions are found to be more extended at the longer wavelengths which implies that there must be a range of dust temperatures in the sources. The properties of the galactic ridge are similar to those of the sources.

  10. Effectiveness of the computer enhanced visual learning method in teaching the society for fetal urology hydronephrosis grading system for urology trainees.

    Science.gov (United States)

    Marks, Andrew; Maizels, Max; Mickelson, Jennie; Yerkes, Elizabeth; Anthony Herndon, C D; Lane, Jerry; Ben-Ami, Tamar; Maizels, Evelyn; Stoltz, Rachel Stork; Dixon, Scott; Liu, Dennis; Chaviano, Tony; Hagerty, Jennifer; Kaplan, William

    2011-04-01

    A novel educational tool, Computer Enhanced Visual Learning (CEVL), has been used to improve resident performance of routine orchiopexy. Our objective was to assess the effect of a CEVL teaching module on the diagnostic accuracy of medical trainees in grading neonatal hydronephrosis on ultrasound using the Society for Fetal Urology (SFU) grading system. The authors designed an online-based computerized tutorial to teach the grading of hydronephrosis using multimedia, practice cases and a grading checklist. In a crossover design trial, 29 residents and medical students were asked to grade 16 standard neonatal renal ultrasounds using the SFU grading system before and after viewing the web-based e-learning module. Primary outcome was percent improvement in grading accuracy. The mean percentages of ultrasounds that were graded correctly before and after CEVL intervention were 51% and 72% respectively (mean improvement 21%, 95% CI 3-13%, P < 0.001). Residents graded correctly 56% of ultrasounds before and 74% after CEVL (mean 18%, 7-28%, P = 0.002). Medical students graded correctly 37% before and 69% after CEVL (mean improvement 32%, 95% CI 16-48%, P = 0.002). Exposure to a computer-based learning module based on the CEVL platform improved urology residents' and medical students' correct assignment of SFU hydronephrosis grading to newborn renal ultrasounds. Copyright © 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

  11. Resistance patterns of nosocomial urinary tract infections in urology departments: 8-year results of the global prevalence of infections in urology study.

    Science.gov (United States)

    Tandogdu, Zafer; Cek, Mete; Wagenlehner, Florian; Naber, Kurt; Tenke, Peter; van Ostrum, Edgar; Johansen, Truls Bjerklund

    2014-06-01

    To present the worldwide antibiotic resistance rates of uropathogens reported in nosocomial urinary tract infections (NAUTI) during the period of 2003-2010. Data from the Global Prevalence Study of Infections in Urology from the period of 2003-2010 were analyzed to evaluate the resistance rates of pathogens causing NAUTI. The web-based application was used to record data of investigators from urology departments participating in the study every year during the days allocated in November. Each center was allowed to enter data on a single day of the study. The point prevalence data was used to find differences among geographic regions and years by utilizing multiple logistic regression analysis. A total of 19,756 patients were hospitalized during the study period, and in 1,866 of them, NAUTI was reported. Proof of infection was reported in 1,395 patients. Resistance rates of all antibiotics tested other than imipenem against the total bacterial spectrum were higher than 10 % in all regions. Resistance to almost all pathogens was lowest in North Europe, and there is no single year where an outbreak of resistance has been detected. The resistance rates of most of the uropathogens against the antibiotics tested did not show significant trends of increase or decrease with Asia exhibiting the highest rates in general. The only antibiotic tested with an overall resistance rate below 10 % was imipenem. Knowledge of regional and local resistance data and prudent use of antibiotics are necessary to optimize antibiotic therapy in urological patients with NAUTI.

  12. Quantification of metallic iodides in fucus vesiculosus and serratus heated at 80 deg, 550 deg and 1 000 deg; Quantification des iodures metalliques dans des cendres d'algues. Analyse de fucus vesiculosus et serratus chauffees a 80 degres, 550 degre et 1000 degre

    Energy Technology Data Exchange (ETDEWEB)

    Aujollet, Y. [Direction Generale de la Surete Nucleaire et de la Radioprotection (DGSNR), 75 - Paris (France)

    2004-02-01

    Metallic iodides in aqueous phase of Fucus ashes were measured by gamma spectrometry. Before the measurements, different samples of Fucus were heated at 80 deg C (Fucus vesiculosus), 550 deg C (Fucus serratus) and 1 000 deg C (Fucus serratus). The first results gave 63% of iodide salts in Fucus vesiculosus heated at 80 deg C, 27% of iodide salts in Fucus serratus (550 deg C) and no result for ashes of Fucus serratus heated at 1 000 deg C, because there was not enough mass of product for a good analysis by gamma spectrometry. (author)

  13. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

    NARCIS (Netherlands)

    Srigley, J.R.; Delahunt, B.; Eble, J.N.; Egevad, L.; Epstein, J.I.; Grignon, D.; Hes, O.; Moch, H.; Montironi, R.; Tickoo, S.K.; Zhou, M.; Argani, P.; Hulsbergen-van de Kaa, C.A.

    2013-01-01

    The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group p

  14. The place of female sexual dysfunction in the urological practice : Results of a Dutch Survey

    NARCIS (Netherlands)

    Bekker, Milou; Beck, Jacky; Putter, Hein; van Driel, Mels; Pelger, Rob; Nijeholt, August Lycklama A.; Elzevier, Henk

    2009-01-01

    Introduction. Female sexual dysfunction (FSD) is a highly prevalent and often underestimated problem. There is a strong association between urological complaints and FSD. Aims. The purpose of this survey was to evaluate how Dutch urologists address FSD in their daily practice. Methods. We performed

  15. Serious renal and urological complications in fast-track primary total hip and knee arthroplasty

    DEFF Research Database (Denmark)

    Bjerregaard, Lars; Jørgensen, Christoffer Calov; Kehlet, Henrik

    2016-01-01

    BACKGROUND: Overall medical complications have been reduced after fast-track total hip (THA) and knee arthroplasty (TKA), but data on specific renal and urological (RU) complications are limited. METHODS: To describe the incidence and consequences of serious RU complications resulting in length o...

  16. A System Approach to Navy Medical Education and Training. Appendix 35. Competency Curriculum for Urology Assistant.

    Science.gov (United States)

    1974-08-31

    28 10. Urethral Calibration, Dilation . . ... ... 29 11. Voiding/Static/cine- Cystograms , Cystourethrograms...9 Cystometrograms . . . .. . . . .. 28 10 Urethral Calibration, Dilation . . . .*. . . . 29 11 Voiding/Static/Cine- Cystograms , Cystourethrograms...urethral sounds 29 I I Competency: UROLOGY ASSISTANT (URA) Unit IV. Endoscopic Procedures MODULE i: VOIDING/STATIC/CINE- CYSTOGRAMS , CYSTOURETHROGRAMS

  17. [Genitourinary tuberculosis in the urologic works of Professor Rafael Mollá Rodrigo].

    Science.gov (United States)

    Cánovas Ivorra, Jose Antonio; Tramoyeres Galván, Alfredo; Sánchez Ballester, Francisco; de la Torre Abril, Luis; Ordoño Domínguez, Felipe; Navalón Verdejo, Pedro; Ramada Benlloch, Francisco; López Alcina, Emilio; Pérez Albacete, Mariano; Zaragoza Orts, Julio

    2005-04-01

    Professor Rafael Molla Rodrigo is considered by some the author who contributed with his scientific work and solid technique to consolidate Urology as a speciality in Valencia. Such importance is also perceived in a national level, as demonstrated by the fact that he belonged to the first board of the Spanish Association of Urology and contributed to its foundation in the two-year period 1910--1911, from his position of head of the department of Surgical Therapy and Operations at the Central University. Genitourinary tuberculosis is one of the most outstanding chapters of his extensive works. We reviewed all his works, selecting all original articles about genitourinary tuberculosis. Original articles have been obtained from the journals Revista de Higiene y Tuberculosis, La Medicina Valenciana, Revista Valenciana de Ciencias Médicas y Policínica, and from his two most important books, Clinical Lessons In Urology and Clinical Lessons in Urology and Genitourinary Surgery. Throughout his work he analyzes features of relevance about this disease, such as diagnosis, about which he emphasizes the clinical and bacteriological difficulties, and treatment, which was only feasible by precocious nephrectomy. He dedicates a great part of his work to the study of this pathology and defends a precocious diagnosis in order to perform the only treatment that had demonstrated efficacy. He also exposes the symptoms and variety of clinical presentations, as well as diagnosis through separate kidney catheterization with the aim to determine unilateral involvement.

  18. Patient satisfaction in urology: effects of hospital characteristics, demographic data and patients' perceptions of received care.

    Science.gov (United States)

    Schoenfelder, Tonio; Schaal, Tom; Klewer, Joerg; Kugler, Joachim

    2014-09-06

    To identify factors that are significantly associated with patient satisfaction in urology and to assess the extent to which satisfaction ratings might be related to hospital and patient characteristics. Data used in this study were obtained from 1040 randomly selected urology patients discharged from nine hospitals who responded to a mailed survey. Bivariate and multivariate techniques were used to reveal relations between patient assessments of received care, hospital and patient characteristics. Bivariate analysis showed a strong association between satisfaction scores and length of stay, provider status, work load of nurses and hospital size, with weaker findings pertaining to type of hospital (teaching versus non-teaching) and patient demographics. The multivariate analysis identified nine vari­ables which are associated with overall satisfaction. Strong factors were treatment outcome, the interper­sonal manner of medical practitioners and nurses, as well as hotel aspects like accommodation and quality of food. Variables reflecting information receiving about the undergoing treatment were not found to have a significant influence on patient satisfaction. This study identified variables that are related to satisfaction in a urological setting and de­livers information about aspects of the hospital stay that are not perceived as relevant by patients. These findings support healthcare professionals with valuable information to meet needs and preferences of pa­tients in urology.

  19. Staff lens doses in interventional urology. A comparison with interventional radiology, cardiology and vascular surgery values.

    Science.gov (United States)

    Vano, E; Fernandez, J M; Resel, L E; Moreno, J; Sanchez, R M

    2016-03-01

    The purpose of this work is to evaluate radiation doses to the lens of urologists during interventional procedures and to compare them with values measured during interventional radiology, cardiology and vascular surgery. The measurements were carried out in a surgical theatre using a mobile C-arm system and electronic occupational dosimeters (worn over the lead apron). Patient and staff dose measurements were collected in a sample of 34 urology interventions (nephrolithotomies). The same dosimetry system was used in other medical specialties for comparison purposes. Median and 3rd quartile values for urology procedures were: patient doses 30 and 40 Gy cm(2); personal dose equivalent Hp(10) over the apron (μSv/procedure): 393 and 848 (for urologists); 21 and 39 (for nurses). Median values of over apron dose per procedure for urologists resulted 18.7 times higher than those measured for radiologists and cardiologists working with proper protection (using ceiling suspended screens) in catheterisation laboratories, and 4.2 times higher than the values measured for vascular surgeons at the same hospital. Comparison with passive dosimeters worn near the eyes suggests that dosimeters worn over the apron could be a reasonable conservative estimate for ocular doses for interventional urology. Authors recommend that at least the main surgeon uses protective eyewear during interventional urology procedures.

  20. Use of Pharmacogenotyping and Dosage of Certain Drugs in the Urology and Nephrology

    Directory of Open Access Journals (Sweden)

    А.А. Melnik

    2016-02-01

    Full Text Available The article is devoted to the use of methods of pharmacogenetically and aspects of dosing of some drugs used in Nephrology and Urology. Described angiotensin converting enzyme inhibitors (aceis, beta-adrenoblockers (BAB, calcium channel blockers (CCB, diuretics.

  1. Urologic complications following obstetrics and gynecologicai surgery: Our experience in a tertiary care hospital

    Directory of Open Access Journals (Sweden)

    Dilip Kumar Pal

    2016-01-01

    Conclusion: Although obstetrical causes are still important in developing countries, gynecological procedures especially laparoscopic surgeries are on the rise. In these procedures the suspicion of urological injuries should be kept in mind and intra-operative detection and early repair should be attempted. Delayed diagnosis and improper treatment leads to severe complications.

  2. Economies of scale, physician volume for urology patients, and DRG prospective hospital payment system.

    Science.gov (United States)

    Munoz, E; Boiardo, R; Mulloy, K; Goldstein, J; Brewster, J G; Wise, L

    1990-11-01

    Diagnosis Related Group (DRG) hospital payment has begun to squeeze hospitals financially and is likely to do so in the future. This study analyzed the relationship between the volume of urologic procedures by an individual urologist, hospital costs per patient, and outcome. We used a three-year DRG database of urology patients (N = 2,980) at an academic medical center to analyze these. Low-volume urologists (arbitrarily defined by us) had higher hospital costs per patient, financial losses versus profits under DRGs, and a poorer outcome when compared with high-volume urologists. Pearson correlation showed a positive relationship between cost per patient and physician volume for nonemergency patients (-0.129, p less than 0.0001) and emergency patients (-0.368, p less than 0.0001). This may have been explained (in part) by a greater severity of illness for patients of low-volume urologists. These findings suggest, however, that the volume of urologic procedures per urologist may be related to hospital resource consumption. The health care financing environment of the future should provide substantial interest in this finding for those involved in the consumption of urologic services.

  3. Epididymitis in Patients with Anorectal Malformations: A Cause for Urologic Concern

    Directory of Open Access Journals (Sweden)

    Brian A. VanderBrink

    2014-10-01

    Full Text Available Introduction Epididymitis in patients with anorectal malformation (ARM represents a unique problem because unlike the general population, an underlying urinary tract problem is frequently identified. We review our experience with epididymitis in ARM population with an emphasis on examining urologic outcomes. Materials and Methods We performed a retrospective review of male patients with ARM cared for from 1980 to 2010. Clinical and pathologic variables recorded included age at presentation, recurrence, associated urologic anomalies, incidence of ureteral fusion with mesonephric ductal structures, glomerular filtration rate and urodynamic parameters. Results Twenty-six patients were identified with documented episodes of epididymitis. Renal injury was noted in five patients (19%, all of whom were diagnosed with neurogenic bladder (NGB several years after anorectoplasty. NGB was found in ten patients (38% in our series. Ectopic insertion of ureter into a mesonephric ductal structure was discovered in five patients (19%. Twelve patients (46% had recurrent episodes of epididymitis, with seven of these patients (58% being diagnosed with NGB. Two patients in the pubertal group presented with a history of epididymitis and complained of ejaculatory pain. Conclusion Epididymitis in a patient with ARM warrants a comprehensive urologic investigation, particularly in recurrent episodes. Attempts at surgical intervention (e.g. vasectomy should be avoided until functional assessment of the urinary tract has occurred. Failure to recognize this association may lead to potentially avoidable complications and morbidity. Long term urological follow up of these patients is warranted to identify at risk patients and minimize renal deterioration

  4. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

    NARCIS (Netherlands)

    Srigley, J.R.; Delahunt, B.; Eble, J.N.; Egevad, L.; Epstein, J.I.; Grignon, D.; Hes, O.; Moch, H.; Montironi, R.; Tickoo, S.K.; Zhou, M.; Argani, P.; Hulsbergen-van de Kaa, C.A.

    2013-01-01

    The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group p

  5. About the Prostate and Urologic Cancer Research Group | Division of Cancer Prevention

    Science.gov (United States)

    The Prostate and Urologic Cancer Research Group conducts and supports research on prostate and bladder cancers, and new approaches to clinical prevention studies including cancer immunoprevention. The group develops, implements and monitors research efforts in chemoprevention, nutrition, genetic, and immunologic interventions, screening, early detection and other prevention strategies. |

  6. 77 FR 18829 - Gastroenterology and Urology Devices Panel of the Medical Devices Advisory Committee; Notice of...

    Science.gov (United States)

    2012-03-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Gastroenterology and Urology Devices Panel of the Medical... Administration (FDA). The meeting will be open to the public. Name of Committee: Gastroenterology and...

  7. 78 FR 25747 - Gastroenterology and Urology Devices Panel of the Medical Devices Advisory Committee; Notice of...

    Science.gov (United States)

    2013-05-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Gastroenterology and Urology Devices Panel of the Medical... Administration (FDA). The meeting will be open to the public. Name of Committee: Gastroenterology and...

  8. 76 FR 71983 - Gastroenterology and Urology Devices Panel of the Medical Devices Advisory Committee; Notice of...

    Science.gov (United States)

    2011-11-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Gastroenterology and Urology Devices Panel of the Medical... Administration (FDA). The meeting will be open to the public. Name of Committee: Gastroenterology and...

  9. 75 FR 57968 - Gastroenterology and Urology Devices Panel of the Medical Devices Advisory Committee; Notice of...

    Science.gov (United States)

    2010-09-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Gastroenterology and Urology Devices Panel of the Medical... Administration (FDA). The meeting will be open to the public. Name of Committee: Gastroenterology and...

  10. Female Sexual Abuse Evaluation in the Urological Practice : Results of a Dutch Survey

    NARCIS (Netherlands)

    Beck, Jack; Bekker, Milou; Van Driel, Mels; Putter, Hein; Pelger, Rob; Nijeholt, A. A. B. Lycklama A.; Elzevier, Henk Willem

    2010-01-01

    Introduction. There is a strong association between urological complaints and a history of sexual abuse, especially in females. It is not known whether urologists integrate these facts in their daily practice. Aim. To evaluate whether Dutch urologists address the issues of sexual abuse in their fema

  11. Female Sexual Abuse Evaluation in the Urological Practice : Results of a Dutch Survey

    NARCIS (Netherlands)

    Beck, Jack; Bekker, Milou; Van Driel, Mels; Putter, Hein; Pelger, Rob; Nijeholt, A. A. B. Lycklama A.; Elzevier, Henk Willem

    Introduction. There is a strong association between urological complaints and a history of sexual abuse, especially in females. It is not known whether urologists integrate these facts in their daily practice. Aim. To evaluate whether Dutch urologists address the issues of sexual abuse in their

  12. Serious renal and urological complications in fast-track primary total hip and knee arthroplasty

    DEFF Research Database (Denmark)

    Bjerregaard, Lars S; Jørgensen, Christoffer C; Kehlet, Henrik

    2016-01-01

    postoperatively. Seven complications . (0.08 %) were urological, mainly haematuria after bladder catheterisation, whereas 5 (0.06 were urosepsis/pyelonephritis. CONCLUSION: The overall incidence of serious RU complications after fast-track THA and TKA was 0.61 %. AKI occurred in 0.49% and was most often due...

  13. In situ observations of BrO over Antarctica - ER-2 aircraft results from 54 deg S to 72 deg S latitude

    Science.gov (United States)

    Brune, W. H.; Anderson, J. G.; Chan, K. R.

    1989-01-01

    Bromine monoxide was observed in situ during nine flights of the NASA ER-2 aircraft from Punta Arenas, Chile (54 deg S latitude), to 72 deg S latitude over the Palmer Peninsula, Antarctica. The first flight for the BrO detection system was on August 28. The distribution of BrO inside the chemically perturbed region defined by greatly elevated ClO abundances was different from that found just outside. Inside, the BrO mixing ratio was 6.1 + or - 1.1 pptv above the 440 K potential temperature surface, 4.7 + or - 2.0 pptv between the 400 and 440 K surfaces, and less than 4 pptv below the 400 K surface. At high latitudes outside the chemically perturbed region, the BrO mixing ratio was 5.4 + or - 1.4 pptv near the 450 K surface, but decreased to 2.9 + or - 1.2 pptv at the 420 K surface. The abundance of BrO showed no discernible temporal trend during the course of the nine flights. Away from the south polar region, at latitudes between 47 deg S and 37 deg N and potential temperatures between 435 and 500 K (18.5- to 20.7-km altitude), the BrO mixing ratio was 0.5-3.0 pptv.

  14. The landscape of systematic reviews in urology (1998 to 2015): an assessment of methodological quality.

    Science.gov (United States)

    Han, Julia L; Gandhi, Shreyas; Bockoven, Crystal G; Narayan, Vikram M; Dahm, Philipp

    2017-04-01

    To assess the quality of published systematic reviews in the urology literature (an extension of our previously reported work), as high-quality systematic reviews play a paramount role in informing evidence-based clinical practice. Our focus was on systematic reviews in the urology literature that incorporated questions of prevention and therapy. To identify such reviews published during a 36-month period (2013-2015), we systematically searched PubMed and hand-searched the table of contents of four major urology journals. Two reviewers independently assessed the methodological quality of those reviews, using the 11-point 'Assessment of Multiple Systematic Reviews' (AMSTAR) instrument. We performed protocol-driven analyses of the data from our present study's 36-month period alone, as well as in aggregate with the data from our previously reported work's study periods (2009-2012 and 1998-2008). In our literature search of the 36-month period (2013-2015), we initially identified 490 possibly relevant reviews, of which 125 met our inclusion criteria. The most common topic of reviews for the 2013-2015 period was oncology (51.2%; n = 64), followed by voiding dysfunction (21.6%; n = 27). The mean [standard deviation (SD)] AMSTAR score in the 2013-2015 period (n = 125) was 4.8 (2.4); 2009-2012 (n = 113), 5.4 (2.3); and 1998-2008 (n = 57), 4.8 (2.0) (P = 0.127). In the 2013-2015 period, the mean (SD) AMSTAR score for the BJU International (n = 25) was 5.6 (2.9); for The Journal of Urology (n = 20), 5.1 (2.6); for European Urology (n = 60), 4.5 (2.2); and for Urology (n = 20), 4.4 (2.2) (P = 0.106). The number of systematic reviews published in the urology literature has exponentially increased, year by year, but their methodological quality has stagnated. To enhance the validity and impact of systematic reviews, all authors and editors must apply established methodological standards. © 2016 The Authors BJU International © 2016 BJU International Published by John Wiley

  15. Bladder management methods and urological complications in spinal cord injury patients

    Directory of Open Access Journals (Sweden)

    Roop Singh

    2011-01-01

    Full Text Available Background: The optimal bladder management method should preserve renal function and minimize the risk of urinary tract complications. The present study is conducted to assess the overall incidence of urinary tract infections (UTI and other urological complications in spinal cord injury patients (SCI, and to compare the incidence of these complications with different bladder management subgroups. Materials and Methods: 545 patients (386 males and 159 females of traumatic spinal cord injury with the mean age of 35.4±16.2 years (range, 18 - 73 years were included in the study. The data regarding demography, bladder type, method of bladder management, and urological complications, were recorded. Bladder management methods included indwelling catheterization in 224 cases, clean intermittent catheterization (CIC in 180 cases, condom drainage in 45 cases, suprapubic cystostomy in 24 cases, reflex voiding in 32 cases, and normal voiding in 40 cases. We assessed the incidence of UTI and bacteriuria as the number of episodes per hundred person-days, and other urological complications as percentages. Results: The overall incidence of bacteriuria was 1.70 / hundred person-days. The overall incidenceof urinary tract infection was 0.64 / hundered person-days. The incidence of UTI per 100 person-days was 2.68 for indwelling catheterization, 0.34 for CIC, 0.34 for condom drainage, 0.56 for suprapubic cystostomy, 0.34 for reflex voiding, and 0.32 for normal voiding. Other urological complications recorded were urethral stricture (n=66, 12.1%, urethritis (n=78, 14.3%, periurethral abscess (n=45, 8.2%, epididymorchitis (n=44, 8.07%, urethral false passage (n=22, 4.03%, urethral fistula (n=11, 2%, lithiasis (n=23, 4.2%, hematuria (n=44, 8.07%, stress incontinence (n=60, 11%, and pyelonephritis (n=6, 1.1%. Clean intermittent catheterization was associated with lower incidence of urological complications, in comparison to indwelling catheterization. Conclusions

  16. Simplified 2DEG carrier concentration model for composite barrier AlGaN/GaN HEMT

    Energy Technology Data Exchange (ETDEWEB)

    Das, Palash, E-mail: d.palash@gmail.com; Biswas, Dhrubes, E-mail: d.palash@gmail.com [Indian Institute of Technology Kharagpur, Kharagpur - 721302, West Bengal (India)

    2014-04-24

    The self consistent solution of Schrodinger and Poisson equations is used along with the total charge depletion model and applied with a novel approach of composite AlGaN barrier based HEMT heterostructure. The solution leaded to a completely new analytical model for Fermi energy level vs. 2DEG carrier concentration. This was eventually used to demonstrate a new analytical model for the temperature dependent 2DEG carrier concentration in AlGaN/GaN HEMT.

  17. Strumentazione multisensore selettiva per il monitoraggio in continuo degli odori nel settore ambientale

    OpenAIRE

    Giuliani, Stefano

    2012-01-01

    2010 - 2011 L’odore indotto dall’esercizio degli impianti di ingegneria sanitaria ambientale è ritenuto la causa principale di disturbo che la popolazione residente nelle vicinanze avverte. Sebbene alle emissioni odorigene sia solo raramente associato un reale rischio tossicologico-sanitario, sia per la natura raramente pericolosa degli odoranti che per le concentrazioni generalmente molto basse, nell’immaginario collettivo, ai cattivi odori si associano spesso condizioni di “non salubrità...

  18. Experimental measurement of the solubility of bismuth phases in water vapor from 220 deg. C to 300 deg. C: Implications for ore formation

    Energy Technology Data Exchange (ETDEWEB)

    Kruszewski, Jason M. [Department of Geological Sciences, University of Idaho, Moscow, ID 83844-3022 (United States); Wood, Scott A., E-mail: swood@uidaho.edu [Department of Geological Sciences, University of Idaho, Moscow, ID 83844-3022 (United States)

    2009-04-15

    Preliminary measurements were carried out of the solubility of the O{sub 2-}buffering assemblage bismuth + bismite (Bi{sub 2}O{sub 3}) in aqueous liquid-vapor and vapor-only systems at temperatures of 220, 250 and 300 deg. C. All experiments were carried out in Ti reaction vessels and were designed such that the Bi solids were contained in a silica tube that prevented contact with liquid water at any time during the experiment. Two blank (no Bi solids present) liquid-vapor experiments at 220 deg. C yielded Bi concentrations ({+-}1{sigma}) in the condensed liquid of 0.22 {+-} 0.02 mg/L, whereas the solubility measurements at this temperature yielded an average value of approximately 6 {+-} 9 mg/L, with replicate experiments ranging from 0.3 to 26 mg/L. Although the 6 mg/L value is associated with a considerable degree of uncertainty, the experiments do indicate transport of Bi through the vapor phase. Measured Bi concentrations in the condensed liquid at 250 deg. C were in the same range as those at 220 deg. C, whereas those at 300 deg. C were significantly lower (i.e., all below the blank value). Vapor-only experiments necessarily contained much smaller initial volumes of water, thereby making the results more susceptible to contamination. Single blank runs at 220 and 300 deg. C yielded Bi concentrations of 82 and 16 mg/L, respectively. Measured concentrations ({+-}1{sigma}) of Bi in the vapor-only solubility experiments at 220 deg. C were 235 {+-} 78 mg/L for an initial water volume of 0.5 mL, and at 300 deg. C were 56 {+-} 30 mg/L and 33 {+-} 21 for initial water volumes of 1 and 2 mL, respectively, suggesting strong preferential partitioning of Bi into the vapor. The results indicate a negative dependence of Bi solubility on temperature, but are inconclusive with respect to the dependence of Bi solubility on water density or fugacity. The experiments reported here suggest that significant Bi transport is possible in the vapor phase. Comparison of the liquid

  19. Evaluation of myocardial SPECT imaging reconstructed from 270deg projection data. A study using a cardiac phantom

    Energy Technology Data Exchange (ETDEWEB)

    Kashikura, Kenichi [Japan Science and Technology Corp., Akita (Japan). Akita Lab.; Kobayashi, Hideki; Kashikura, Akemi

    1997-01-01

    SPECT reconstruction is commonly performed using 360deg or 180deg projection data. However, it is also possible to reconstruct SPECT images using other projection data arcs. The purpose of this study was to characterize images obtained by limiting the projection data to 270deg by discarding the projection views with severe attenuation. A series of phantom studies was performed with and without plastic chambers simulating perfusion defects using {sup 201}Tl and {sup 99m}Tc. Images using 270deg, 360deg, and 180deg projection arcs were identically reconstructed from the same data. In the absence of plastic chambers, intraslice uniformity in a given slice was assessed by computing the coefficient of variation (CV) of average counts in 8 ROIs within the slice. Interslice uniformity was assessed by computing the CV of average counts in five short axial slices. With plastic chambers in place, the variability in defect contrasts was assessed by computing the CV of defect contrasts in 4 chambers, located on the anterior, lateral, inferoposterior, and septal walls. The intraslice uniformity of the 270deg images were considerably inferior to those of the 360deg and 180deg images. The interslice uniformity was highest in the 360deg images, and lowest in the 180deg images. The variation in defect contrasts in the 270deg image was higher than those of the other two images. The 270deg images showed a high defect contrast in the septum and high counts in the anterior and anteroseptal wall. Because a large variation in defect contrasts within a segment might result in false positive or negative in diagnosis, 270deg imaging is not recommended over 360deg or 180deg imaging. (author)

  20. Expert Involvement Predicts mHealth App Downloads: Multivariate Regression Analysis of Urology Apps

    Science.gov (United States)

    Osório, Luís; Cavadas, Vitor; Fraga, Avelino; Carrasquinho, Eduardo; Cardoso de Oliveira, Eduardo; Castelo-Branco, Miguel; Roobol, Monique J

    2016-01-01

    Background Urological mobile medical (mHealth) apps are gaining popularity with both clinicians and patients. mHealth is a rapidly evolving and heterogeneous field, with some urology apps being downloaded over 10,000 times and others not at all. The factors that contribute to medical app downloads have yet to be identified, including the hypothetical influence of expert involvement in app development. Objective The objective of our study was to identify predictors of the number of urology app downloads. Methods We reviewed urology apps available in the Google Play Store and collected publicly available data. Multivariate ordinal logistic regression evaluated the effect of publicly available app variables on the number of apps being downloaded. Results Of 129 urology apps eligible for study, only 2 (1.6%) had >10,000 downloads, with half having ≤100 downloads and 4 (3.1%) having none at all. Apps developed with expert urologist involvement (P=.003), optional in-app purchases (P=.01), higher user rating (P<.001), and more user reviews (P<.001) were more likely to be installed. App cost was inversely related to the number of downloads (P<.001). Only data from the Google Play Store and the developers’ websites, but not other platforms, were publicly available for analysis, and the level and nature of expert involvement was not documented. Conclusions The explicit participation of urologists in app development is likely to enhance its chances to have a higher number of downloads. This finding should help in the design of better apps and further promote urologist involvement in mHealth. Official certification processes are required to ensure app quality and user safety. PMID:27421338

  1. Nationwide Trends and Variations in Urological Surgical Interventions and Renal Outcome in Patients with Spina Bifida.

    Science.gov (United States)

    Wang, Hsin-Hsiao S; Lloyd, Jessica C; Wiener, John S; Routh, Jonathan C

    2016-04-01

    Bladder dysfunction in patients with spina bifida can lead to significant morbidity due to renal insufficiency. Indications for surgery vary among institutions and the impact is unclear. We examined trends and variations in urological interventions and chronic renal insufficiency in patients with spina bifida. We reviewed NIS (Nationwide Inpatient Sample) for all patients with spina bifida treated from 1998 to 2011. We used ICD-9-CM codes to identify urological surgery and chronic renal insufficiency. We calculated the Spearman correlation coefficients between rates of spina bifida related bladder surgeries and rates of chronic renal insufficiency outcomes by state. Linear regression models were fitted to investigate the associations between rates of spina bifida related surgery and chronic renal insufficiency across treatment years. We identified 427,616 spina bifida hospital admissions. Mean patient age was 26 years and 56% of patients were female. Of the admissions 35,249 (8%) were for chronic renal insufficiency and 11,078 (3%) were for surgery. During the study period chronic renal insufficiency rates doubled from 6% to 12% and surgery rates decreased from 2.0% to 1.8%. There was a moderately weak inverse association between surgery and chronic renal insufficiency rates with time (r = -0.3, p = 0.06) and by state (r = -0.3, p = 0.04). On multivariate analysis higher rates of surgery were associated with the state in which the patient was treated (p spina bifida related surgery (p = 0.67). We observed a temporal and geographic trend toward decreasing urological surgery and increasing chronic renal insufficiency rates in spina bifida and a wide variation in urological surgical rates among states. Further study is needed to determine the factors behind these trends and variations in spina bifida management. Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  2. Survey on lower urinary tract symptoms and sleep disorders in patients treated at urology departments

    Directory of Open Access Journals (Sweden)

    Shimizu N

    2013-01-01

    Full Text Available Nobutaka Shimizu,1 Yasuharu Nagai,1 Yutaka Yamamoto,1 Takafumi Minami,1 Taiji Hayashi,1 Hidenori Tsuji,1 Masahiro Nozawa,1 Kazuhiro Yoshimura,1 Tokumi Ishii,1 Hirotsugu Uemura,1 Takashi Oki,2 Koichi Sugimoto,2 Kazuhiro Nose,2 Tsukasa Nishioka21Department of Urology, Kinki University Faculty of Medicine, Osaka, Japan; 2Department of Urology, Sakai Hospital, Kinki University Faculty of Medicine, Osaka, JapanObjectives: This study examined the association between sleep disorders and lower urinary tract symptoms in patients who had visited urology departments.Methods: This was an independent cross-sectional, observational study. Outpatients who had visited the urology departments at the Kinki University School of Medicine or the Sakai Hospital, Kinki University School of Medicine, between August 2011 and January 2012 were assessed using the Athens Insomnia Scale and the International Prostate Symptom Score.Results: In total, 1174 patients (mean age, 65.7 ± 13.7 years, with 895 men (67.1 ± 13.2 years old and 279 women (61.4 ± 14.6 years old, were included in the study. Approximately half of these patients were suspected of having a sleep disorder. With regard to the International Prostate Symptom Score subscores, a significant increase in the risk for suspected sleep disorders was observed among patients with a post-micturition symptom (the feeling of incomplete emptying subscore of ≥1 (a 2.3-fold increase, a storage symptom (daytime frequency + urgency + nocturia subscore of ≥5 (a 2.7-fold increase, a voiding symptom (intermittency + slow stream + hesitancy subscore of ≥2 (a 2.6-fold increase, and a nocturia subscore of ≥2 (a 1.9-fold increase.Conclusion: The results demonstrated that the risk factors for sleep disorders could also include voiding, post-micturition, and storage symptoms, in addition to nocturia.Keywords: lower urinary tract symptoms, sleep disturbance, urological disease

  3. Indications and results of the unilateral /sup 123/I-hippurate-clearance in an ambulant urological-nephrological patients collective

    Energy Technology Data Exchange (ETDEWEB)

    Mariss, P.; Haubold, E.

    1988-02-01

    In 572 nephrological-urological ambulant patients 688 estimations of unilateral renal plasma flow were performed after application of 300 kBq/kg /sup 123/I-hippurate using a large field scintillation camera, external scintillation probe over the right shoulder and a computer system. The indications were patients with hypertension, chronic pyelonephritis, unilateral nephrocirrhosis, exclusion or approval of renal failure, furthermore diverse malformations of the urovesical system, nephrolithiasis and follow-up after urological operations. The unilateral renal clearance by /sup 123/I-hippurate represents an important diagnostic tool in urological-nephrological patients with special diseases in addition to morphological and microbiological methods.

  4. Deletion of degQ gene enhances outer membrane vesicle production of Shewanella oneidensis cells.

    Science.gov (United States)

    Ojima, Yoshihiro; Mohanadas, Thivagaran; Kitamura, Kosei; Nunogami, Shota; Yajima, Reiki; Taya, Masahito

    2017-04-01

    Shewanella oneidensis is a Gram-negative facultative anaerobe that can use a wide variety of terminal electron acceptors for anaerobic respiration. In this study, S. oneidensis degQ gene, encoding a putative periplasmic serine protease, was cloned and expressed. The activity of purified DegQ was inhibited by diisopropyl fluorophosphate, a typical serine protease-specific inhibitor, indicating that DegQ is a serine protease. In-frame deletion and subsequent complementation of the degQ were carried out to examine the effect of envelope stress on the production of outer membrane vesicles (OMVs). Analysis of periplasmic proteins from the resulting S. oneidensis strain showed that deletion of degQ induced protein accumulation and resulted in a significant decrease in protease activity within the periplasmic space. OMVs from the wild-type and mutant strains were purified and observed by transmission electron microscopy. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the OMVs showed a prominent band at ~37 kDa. Nanoliquid chromatography-tandem mass spectrometry analysis identified three outer membrane porins (SO3896, SO1821, and SO3545) as dominant components of the band, suggesting that these proteins could be used as indices for comparing OMV production by S. oneidensis strains. Quantitative evaluation showed that degQ-deficient cells had a fivefold increase in OMV production compared with wild-type cells. Thus, the increased OMV production following the deletion of DegQ in S. oneidensis may be responsible for the increase in envelope stress.

  5. Robotic laparoendoscopic single-site surgery(R-LESS):current status in urology%Robotic laparoendoscopic single-site surgery(R-LESS) :current status in urology

    Institute of Scientific and Technical Information of China (English)

    Riccardo Autorino; YANG Bo; Jihad H. Kaouk

    2011-01-01

    Laparoendoscopic single-site surgery (LESS) is technically challenging; it can reduces instrument triangulation and robust retraction and is associated with a steep learning curve.The instruments of the daVinci(R) surgical system (Intuitive Surgical) are designed with seven degrees of motion mimicing the dexterity of the human hand and wrist.This inherent feature of the robotic arm provides superior ergonomics when performing LESS,especially for complex reconstructive surgery.This review analyzes the evidence supporting current and future application of robotic technology in the field of urologic LESS.

  6. Phosphorylated DegU Manipulates Cell Fate Differentiation in the Bacillus subtilis Biofilm

    Science.gov (United States)

    Marlow, Victoria L.; Porter, Michael; Hobley, Laura; Kiley, Taryn B.; Swedlow, Jason R.; Davidson, Fordyce A.

    2014-01-01

    Cell differentiation is ubiquitous and facilitates division of labor and development. Bacteria are capable of multicellular behaviors that benefit the bacterial community as a whole. A striking example of bacterial differentiation occurs throughout the formation of a biofilm. During Bacillus subtilis biofilm formation, a subpopulation of cells differentiates into a specialized population that synthesizes the exopolysaccharide and the TasA amyloid components of the extracellular matrix. The differentiation process is indirectly controlled by the transcription factor Spo0A that facilitates transcription of the eps and tapA (tasA) operons. DegU is a transcription factor involved in regulating biofilm formation. Here, using a combination of genetics and live single-cell cytological techniques, we define the mechanism of biofilm inhibition at high levels of phosphorylated DegU (DegU∼P) by showing that transcription from the eps and tapA promoter regions is inhibited. Data demonstrating that this is not a direct regulatory event are presented. We demonstrate that DegU∼P controls the frequency with which cells activate transcription from the operons needed for matrix biosynthesis in favor of an off state. Subsequent experimental analysis led us to conclude that DegU∼P functions to increase the level of Spo0A∼P, driving cell fate differentiation toward the terminal developmental process of sporulation. PMID:24123822

  7. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters

    NARCIS (Netherlands)

    Delahunt, B.; Cheville, J.C.; Martignoni, G.; Humphrey, P.A.; Magi-Galluzzi, C.; McKenney, J.; Egevad, L.; Algaba, F.; Moch, H.; Grignon, D.J.; Montironi, R.; Srigley, J.R.; Hulsbergen-van de Kaa, C.A.

    2013-01-01

    The International Society of Urological Pathology 2012 Consensus Conference made recommendations regarding classification, prognostic factors, staging, and immunohistochemical and molecular assessment of adult renal tumors. Issues relating to prognostic factors were coordinated by a workgroup who id

  8. Appearance of urology at the beginining of xxth century -from the general surgeon up to the highly trained specialist

    Directory of Open Access Journals (Sweden)

    Ignjatović Ivan M.

    2003-01-01

    Full Text Available Evolvement of urology as a separate scientific discipline depends on several factors. Endoscopic diagnostics, radiological diagnostics, and operative techniques in general surgery, had provided an ability to perform more complex and longer operations. Urology had evolved from the great schools of surgery in Germany and France, and their the most important surgeons, who were intersted in urological surgery. The first endoscope was introduced in 1806, and received today’s form in 1879. Application of "X" rays in medicine started in 1895, and it was later applied as a cystography, retrograde pyelography as well as intravenous urography. The most important thing for the operative technique evolution were application of anhestesia, asepsis and new hemostatic devices. During the one century long development, urology had passed the way from completely unknown field, up to the discipline with the best diagnostic preciseness.

  9. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters

    NARCIS (Netherlands)

    Delahunt, B.; Cheville, J.C.; Martignoni, G.; Humphrey, P.A.; Magi-Galluzzi, C.; McKenney, J.; Egevad, L.; Algaba, F.; Moch, H.; Grignon, D.J.; Montironi, R.; Srigley, J.R.; Hulsbergen-van de Kaa, C.A.

    2013-01-01

    The International Society of Urological Pathology 2012 Consensus Conference made recommendations regarding classification, prognostic factors, staging, and immunohistochemical and molecular assessment of adult renal tumors. Issues relating to prognostic factors were coordinated by a workgroup who id

  10. The Structure of Dark Molecular Gas in the Galaxy - I: A Pilot Survey for 18-cm OH Emission Towards $l \\approx 105^{\\deg}, b \\approx +1^{\\deg}$

    CERN Document Server

    Allen, Ronald J; Engelke, Philip D

    2015-01-01

    We report the first results from a survey for 1665, 1667, and 1720 MHz OH emission over a small region of the Outer Galaxy centered at $l \\approx 105.0\\deg , b \\approx +1.0\\deg$ . This sparse, high-sensitivity survey ($\\Delta Ta \\approx \\Delta Tmb \\approx 3.0 - 3.5$ mK rms in 0.55 km/s channels), was carried out as a pilot project with the Green Bank Telescope (GBT, FWHM $\\approx 7.6'$) on a 3 X 9 grid at $0.5\\deg$ spacing. The pointings chosen correspond with those of the existing $^{12}$CO(1-0) CfA survey of the Galaxy (FWHM $\\approx 8.4'$). With 2-hr integrations, 1667 MHz OH emission was detected with the GBT at $\\gtrsim 21$ of the 27 survey positions ($\\geq 78\\%$ ), confirming the ubiquity of molecular gas in the ISM as traced by this spectral line. With few exceptions, the main OH lines at 1665 and 1667 MHz appear in the ratio of 5:9 characteristic of LTE at our sensitivity levels. No OH absorption features are recorded in the area of the present survey, in agreement with the low levels of continuum bac...

  11. Analysis of the thin layer of Galactic warm ionized gas in the range 20 < l < 30 deg, -1.5 < b < +1.5 deg

    CERN Document Server

    Paladini, R; Davies, R D; Giard, M

    2005-01-01

    We present an analysis of the thin layer of Galactic warm ionized gas at an angular resolution ~ 10'. This is carried out using radio continuum data at 1.4 GHz, 2.7 GHz and 5 GHz in the coordinate region 20 < l < 30 deg, -1.5 < b < +1.5 deg. For this purpose, we evaluate the zero level of the 2.7 and 5 GHz surveys using auxiliary data at 2.3 GHz and 408 MHz. The derived zero level corrections are T_{zero}(2.7 GHz)=0.15 +/- 0.06 K and T_{zero}(5 GHz)=0.1 +/- 0.05 K. We separate the thermal (free-free) and non-thermal (synchrotron) component by means of a spectral analysis performed adopting an antenna temperature spectral index -2.1 for the free-free emission, a realistic spatial distribution of indices for the synchrotron radiation and by fitting, pixel-by-pixel, the Galactic spectral index. We find that at 5 GHz, for |b| = 0 deg, the fraction of thermal emission reaches a maximum value of 82%, while at 1.4 GHz, the corresponding value is 68%. In addition, for the thermal emission, the analysis in...

  12. SAS-2 observations of the diffuse gamma radiation in the galactic latitude interval 10 deg absolute b or equal to 90 deg

    Science.gov (United States)

    Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Thompson, D. J.; Oegelman, H. B.; Oezel, M. E.; Tuemer, T.

    1977-01-01

    An analysis of all of the second small astronomy satellite gamma-ray data for galactic latitudes with the absolute value of b 10 deg has shown that the intensity varies with galactic latitude, being larger near 10 deg than 90 deg. For energies above 100 MeV the gamma-ray data are consistent with a latitude distribution of the form I(b) = C sub 1 + C sub 2/sin b, with the second term being dominant. This result suggests that the radiation above 100 MeV is coming largely from local regions of the galactic disk. Between 35 and 100 MeV, a similar equation is also a good representation of the data, but here the two terms are comparable. These results indicate that the diffuse radiation above 35 MeV consists of two parts, one with a relatively hard galactic component and the other an isotropic, steep spectral component which extrapolates back well to the low energy diffuse radiation. The steepness of the diffuse isotropic component places significant constraints on possible theoretical models of this radiation.

  13. Circulation au moyen âge des matériaux ferreux issus des Pyrénées ariégeoises et de la Lombardie. Apport du couplage des analyses en éléments traces et multivariées

    OpenAIRE

    Leroy, Stéphanie

    2010-01-01

    This provenance study concerns the trade understanding in the Middle Ages of iron objects originally from specific ironmaking processes linked to the use of manganese rich ores. We were particularly interested in the case studies of the Ariège (French Pyrenees) and the Lombardy (Italian Alps) areas, two separate geographic areas that held a major place in the medieval economy of their region. This work deals with three specific historical questions. The first part is to clarify the trade rout...

  14. Is sperm banking of interest to patients with nongerm cell urological cancer before potentially fertility damaging treatments?

    Science.gov (United States)

    Salonia, Andrea; Gallina, Andrea; Matloob, Rayan; Rocchini, Lorenzo; Saccà, Antonino; Abdollah, Firas; Colombo, Renzo; Suardi, Nazareno; Briganti, Alberto; Guazzoni, Giorgio; Rigatti, Patrizio; Montorsi, Francesco

    2009-09-01

    We assessed the opinions of patients with nongerm cell urological cancer on sperm banking before undergoing surgical or nonsurgical therapy that could potentially endanger subsequent fertility. Between April 2007 and July 2008, 753 patients visited a urological office and were invited to complete a brief self-administered questionnaire to assess opinions on sperm banking before undergoing any eventual therapy potentially dangerous for male fertility. Logistic regression models tested the association between predictors (age, educational level, relationship status, previous fatherhood and benign disorder vs nongerm cell urological cancer) and patient wishes for sperm banking. Median patient age was 65 years (mean 61.6, range 18 to 76). Overall 522 patients (69.3%) had nongerm cell urological cancer and only 242 (32.1%) were in favor of pretreatment sperm banking. On univariate analysis age (OR 0.961, p banking, whereas having cancer and educational status were not significantly correlated. Multivariate analysis indicated that aging (OR 0.966, p = 0.001) and previous fatherhood (OR 0.587, p = 0.029) maintained inverse associations. Having urological cancer was positively (OR 1.494, p = 0.045) associated with the wish for sperm banking. In urological patients there is a low rate of willingness to bank sperm before any potential fertility damaging therapeutic approach. Having nongerm cell urological cancer is an independent predictor that is positively associated with the wish to bank sperm. It is vitally important to provide comprehensive information about pretreatment sperm banking to young adults with nongerm cell urological cancer.

  15. Strategies to improve the efficiency and utility of multidisciplinary team meetings in urology cancer care: a survey study

    OpenAIRE

    Lamb, Benjamin W; Jalil, Rozh T; Sevdalis, Nick; Vincent, Charles; Green, James S A

    2014-01-01

    Background The prevalence of multidisciplinary teams (MDT) for the delivery of cancer care is increasing globally. Evidence exists of benefits to patients and healthcare professionals. However, MDT working is time and resource intensive. This study aims to explore members’ views on existing practices of urology MDT working, and to identify potential interventions for improving the efficiency and productivity of the MDT meeting. Methods Members of urology MDTs across the UK were purposively re...

  16. Association of BMI and pediatric urologic postoperative events: Results from pediatric NSQIP.

    Science.gov (United States)

    Kurtz, Michael P; McNamara, Erin R; Schaeffer, Anthony J; Logvinenko, Tanya; Nelson, Caleb P

    2015-08-01

    Elevated body mass index (BMI) is a well-known risk factor for perioperative complications in adults, but has not been investigated in children undergoing urologic procedures. Given the low rate of complications associated with urologic surgery, a large sample is required for their characterization, but BMI is frequently not available in administrative databases. Here we report results from the first nationally based, prospectively assembled cohort analyzed with respect to the association of BMI with 30-day postoperative events for pediatric urologic procedures. To determine the association of elevated BMI with overall 30-day postoperative events and wound complications in a large national sample of children undergoing urologic procedures. We queried the 2012 Pediatric National Surgical Quality Improvement Program database (NSQIP), defining obesity as a BMI above the 95th percentile and overweight above the 85th percentile, per CDC definitions. We used BMI pediatric-specific comorbidity score, and procedures were classified as genital, abdominal without bowel involvement, or abdominal with bowel involvement. Univariate and multivariate logistic models were used to test significance of associations. 2871 patients aged 2-18 years were analyzed. Of these, 420 (14.6%) were overweight and 440 (15.3%) were obese. A summary of 30-day events and complications is shown in the structured abstract table. On multivariate analysis adjusting for age, gender, class of procedure, and comorbidity, BMI remained a significant risk factor for 30-day events when comparing BMI ≥85th percentile to BMI 85th percentile on multivariate analysis. Overweight/obese status increased the odds of overall complications by 36%, and of wound complications by 140%. In adults there is a known profound effect of body composition on wound complications, but in children this association is less clear, and has not been studied in the pediatric urologic literature on a large scale. The mechanisms linking

  17. Applications of neuromodulation of the lower urinary tract in female urology

    Directory of Open Access Journals (Sweden)

    Firouz Daneshgari

    2006-06-01

    Full Text Available Neuromodulation is becoming part of clinical armamentarium for treatment of a variety of lower urinary tract conditions in female urology. Its increased usage stems from need of patients who have exhausted all other therapeutic options for their complex and poorly understood lower urinary tract disorders. Currently neuromodulation may consist of the use of sacral nerve stimulation (SNS and injectable therapies. Herein, we will discuss the background and development of SNS, its current indications, methods of patient selection and will review the results of the recent published literature on SNS. In addition, we will discuss some of the newer developments in SNS such as Bion device and the future direction in integration of SNS in female urology.

  18. Transurethral prostatectomy: practice aspects of the dominant operation in American urology.

    Science.gov (United States)

    Holtgrewe, H L; Mebust, W K; Dowd, J B; Cockett, A T; Peters, P C; Proctor, C

    1989-02-01

    In a national survey of all American urologists transurethral prostatectomy accounted for 38 per cent of the major surgical procedures performed by the respondents. They regarded the operation as complex and they believe achievement of proficiency requires that more be performed during residency training than any other urological operation. Furthermore, they assigned transurethral prostatectomy a significantly higher relative value than have medical economists doing research in the field of physician reimbursement. The effect of recent legislated congressional reductions in the allowable Medicare fees for transurethral prostatectomy is discussed along with the impact of these reductions on urological patient care and the American urologist. Practice patterns and geographic variations in the costs of transurethral prostatectomy also are considered.

  19. American Urological Association survey of transurethral prostatectomy and the impact of changing medicare reimbursement.

    Science.gov (United States)

    Holtgrewe, H L

    1990-08-01

    The American Urological Association, in a survey of all American urologists, found that TURP accounts for 38 per cent of their major surgery and also found that activities associated with the operation account for nearly 25 per cent of their total patient workload. American urologists regard TURP as complex, and they believe proficiency requires more practical case experience during residency training than is required for any other urologic operation. American urologists assign TURP a significantly higher relative value than that proposed in the pending national Medicare Fee Schedule formulated by medical economists and the Physician Payment Review Commission. The legislated reductions in allowable Medicare fees for TURP and the possible shift in management of benign prostatic hyperplasia to nonsurgical methods create a financial vulnerability for American urologists who remain economically dependent on this dominant operation. Adjustments in practice patterns and manpower policy planning may well be required.

  20. Electrical spin injection and detection in high mobility 2DEG systems

    Science.gov (United States)

    Ciorga, M.

    2016-11-01

    In this review paper we present the current status of research related to the topic of electrical spin injection and detection in two-dimensional electron gas (2DEG) systems, formed typically at the interface between two III-V semiconductor compounds. We discuss both theoretical aspects of spin injection in case of ballistic transport as well as give an overview of available reports on spin injection experiments performed on 2DEG structures. In the experimental part we focus particularly on our recent work on all-semiconductor structures with a 2DEG confined at an inverted GaAs/(Al,Ga)As interface and with a ferromagnetic semiconductor (Ga,Mn)As employed as a source of spin-polarized electrons.

  1. Ten deg off-axis tensile test for intralaminar shear characterization of fiber composites

    Science.gov (United States)

    Chamis, C. C.; Sinclair, J. H.

    1976-01-01

    A combined theoretical and experimental investigation was conducted to assess the suitability of the 10 deg off-axis tensile test specimen for the intralaminar shear characterization of unidirectional composites. Composite mechanics, a combined-stress failure criterion, and a finite element analysis were used to determine theoretically the stress-strain variation across the specimen width and the relative stress and strain magnitudes at the 10 deg plane. Strain gages were used to measure the strain variation across the specimen width at specimen midlength and near the end tabs. Specimens from Mod-I/epoxy, T-300/epoxy, and S-glass/epoxy were used in the experimental program. It was found that the 10 deg off-axis tensile test specimen is suitable for intralaminar shear characterization and it is recommended that it should be considered as a possible standard test specimen for such a characterization.

  2. Giovanni Degli Alessandri: i primi anni del direttorato agli Uffizi fra nuovi e vecchi ruoli

    Directory of Open Access Journals (Sweden)

    Chiara Pasquinelli

    2011-11-01

    Full Text Available La figura di Giovanni Degli Alessandri (1765-1830, presidente dell’Accademia di Belle Arti di Firenze e direttore degli Uffizi tra gli anni napoleonici e la Restaurazione di Ferdinando III d’Asburgo-Lorena, è quella di un personaggio chiave nella politica artistica fiorentina, e toscana più in generale. Nel saggio si esaminano i primi anni del suo direttorato alla Galleria, i rapporti con Antonio Canova, il suo ruolo all’interno dell’entourage di Elisa Baciocchi Bonaparte, oltre a considerare alcuni spunti legati al rinnovamento degli Uffizi, nonché la delicata vicenda del passaggio in città di Dominique-Vivant Denon, direttore del Louvre. L’obbiettivo è quello di introdurre elementi di approfondimento relativamente a una figura molto nota ma poco studiata.

  3. A high sensitivity HI survey of the sky at delta < -25 deg Final data release

    CERN Document Server

    Bajaja, E; Larrarte, J J; Morras, R; Poppel, W G L; Kalberla, P M W

    2005-01-01

    We present the final data release of the high sensitivity lambda 21-cm neutral hydrogen survey of the sky south of delta < -25 degr. A total of 50980 positions lying on a galactic coordinate grid with points spaced by (Delta l, Delta b) = ((0.5 deg)/cos b, 0.5 deg) were observed with the 30-m dish of the Instituto Argentino de Radioastronomia (IAR). The angular resolution of the survey is HPBW = 0.5 deg and the velocity coverage spans the interval -450 km/s to +400 km/s (LSR). The velocity resolution is 1.27 km/s and the final rms noise of the entire database is 0.07 K. The data are corrected for stray radiation and converted to brightness temperatures.

  4. Comparative study of scientific publications in urology and nephrology journals originating from USA, China and Japan (2001-2010).

    Science.gov (United States)

    Li, Juan; Gao, Xian Hua; Bian, Qi; Guo, Zhi Yong; Mei, Xiao Bin; Yu, Guang; Wu, Hao; Lai, Xue Li; Chen, Wei

    2012-01-01

    In the past decade, scientific research has developed rapidly in China, but the growth seems to vary widely between different disciplines. In this study, we aimed to compare the quantity and quality of publications in urology and nephrology journals from USA, China and Japan. Journals listed in the "Urology and Nephrology" category of Science Citation Index Expanded subject categories were included. Scientific papers in these journals written by researchers from USA, Japan and China were retrieved from the "PubMed" and "Web of Knowledge" online databases. The annual number of total scientific articles increased significantly from 2001 to 2010 in China, and has ranked second in the world since 2006. In the field of urology and nephrology, the annual number increased significantly from 2001 to 2010 in USA and China; but not in Japan. The share of articles increased significantly over time in China, decreased significantly in Japan, and remained unchanged in USA. In 2010, USA contributed 32.17% of the total world output in urology and nephrology field and ranked 1(st); Japan contributed 5.19% and ranked 5(th); China contributed 3.83% and ranked 9(th). Publications from USA had the highest accumulated IFs and the highest total citations of articles (USA>Japan>China, pJapan(6704)>China(2233), pJapan>China, pscientific publication in urology and nephrology journals in the past decade, it still lags far behind USA and Japan in the field of urology and nephrology in terms of quantity and quality.

  5. Jogging-induced spontaneous peri-renal hemorrhage: a rare urologic emergency.

    Science.gov (United States)

    Jabbour, Michel; Dalati, Mohamad-Fadi

    2014-01-01

    Spontaneous peri-renal hemorrhage (SPH), also known as Wünderlich's syndrome, is an uncommon and rare urologic emergency, which could become life-threatening, requiring immediate diagnosis and management. The diagnosis can be challenging, even with new imaging modalities, and management can vary from conservative approach, to surgical intervention. We present a case of jogging-induced SPH diagnosed using CT scan that was managed conservatively, with follow-up for up to five years using CT imaging studies.

  6. Preliminary Study of Pet Owner Adherence in Behaviour, Cardiology, Urology, and Oncology Fields

    OpenAIRE

    Zita Talamonti; Chiara Cassis; Brambilla, Paola G.; Paola Scarpa; Damiano Stefanello; Simona Cannas; Michela Minero; Clara Palestrini

    2015-01-01

    Successful veterinary treatment of animals requires owner adherence with a prescribed treatment plan. The aim of our study was to evaluate and compare the level of adherence of the owners of patients presented for behavioural, cardiological, urological, and oncological problems. At the end of the first examination, each owner completed a questionnaire. Then, the owners were called four times to fill out another questionnaire over the phone. With regard to the first questionnaire, statisticall...

  7. Xenogenic extracellular matrices as potential biomaterials for interposition grafting in urological surgery.

    LENUS (Irish Health Repository)

    Davis, N F

    2012-01-31

    PURPOSE: The field of tissue engineering focuses on developing strategies for reconstructing injured, diseased, and congenitally absent tissues and organs. During the last decade urologists have benefited from remodeling and regenerative properties of bioscaffolds derived from xenogenic extracellular matrices. We comprehensively reviewed the current literature on structural and functional characteristics of xenogenic extracellular matrix grafting since it was first described in urological surgery. We also reviewed the clinical limitations, and assessed the potential for safe and effective urological application of extracellular matrix grafting in place of autogenous tissue. MATERIALS AND METHODS: We performed literature searches for English language publications using the PubMed(R) and MEDLINE(R) databases. Keywords included "xenogenic," "extracellular matrix" and "genitourinary tract applications." A total of 112 articles were scrutinized, of which 50 were suitable for review based on clinical relevance and importance of content. RESULTS: Since the mid 1990s xenogenic extracellular matrices have been used to successfully treat a number of pathological conditions that affect the upper and lower genitourinary tract. They are typically prepared from porcine organs such as small intestine and bladder. These organs are harvested and subjected to decellularization and sterilization techniques before surgical implantation. Bioinductive growth factors that are retained during the preparation process induce constructive tissue remodeling as the extracellular matrix is simultaneously degraded and excreted. However, recent documented concerns over durability, decreased mechanical strength and residual porcine DNA after preparation techniques have temporarily hampered the potential of extracellular matrices as a reliable replacement for genitourinary tract structures. CONCLUSIONS: Extracellular matrices are a useful alternative for successfully treating a number of urological

  8. Computer system for remote consultations in the diagnosis of urological malignancies

    Science.gov (United States)

    Zaytsev, S. M.; Nikitaev, V. G.; Pronichev, A. N.; Onykiy, B. N.; Polyakov, E. V.; Kurdin, A. A.; Pushkar, D. Y.; Prilepskaya, E. A.; Kovilina, M. V.; Govorov, A. V.; Glotov, A. V.; Vasilyev, A. O.; Kolontarev, K. V.

    2017-01-01

    The complex for the decision support in diagnosis of prostate diseases with using expert knowledge and remote consultations in the process of urologic diseases diagnosis with using prostate preparation images was proposed. The complex allows to ensure consistency in the actions of doctors for remote consultation (areas of interest, marking, and search for informative objects in the preparation images) and to use experts knowledge in cases that are difficult to diagnose.

  9. [Urology and National Socialism. Paul Rosenstein 1875-1964, the disrupted biography of a Jewish urologist].

    Science.gov (United States)

    Moll, F H; Krischel, M; Rathert, P; Fangerau, H

    2011-09-01

    The biography of Paul Rosenstein (1875-1964) serves as an example of the fate of a Jewish scientist at the beginning of the twentieth century in an area of conflict between the development of urology as a specialty at greater urban hospitals, professional achievements as a surgeon and scientist, drastic breaks during Nazi era and escape from Nazi terror via New York to Brazil.

  10. Urological complications after 134 pediatric kidney transplants: a single-center study.

    Science.gov (United States)

    Almeida, F; Branco, F; Cavadas, V; Ribeiro, S; Osório, L; Rocha, A; Ramos, M; Martins, L; Castro-Henriques, A; Mota, C; Reis, A; Fraga, A

    2013-04-01

    The incidence of surgical complications after kidney transplantation has been reported to range from 1% to 33%. The aim of this work was to report surgical urological complications among our cohort of 134 pediatric kidney transplantations. Epidemiological and clinical data of all patients younger than 18 years transplanted between January 1984 and May 2012 were collected from our prospective database. Urologic complications and management are reported herein. One hundred twenty-four patients, including 44% females underwent 134 renal transplants. Median age at the time of the surgery was 13 years. Mean time of end-stage renal disease was 25 months. We identified 10 subjects (7.5%) with urological complications: 5 ureterovesical stenoses, 2 lymphoceles, and 3 lower ureteral fistulas. All of the renal allografts were obtained from cadaveric donors. Mean age of these patients at the time of transplantation was 13 years. Mean cold ischemia time was 1613 minutes. All the patients required surgical management. All patients with ureterovesical stenoses underwent ureteral reimplantation using a Boari flap; those with lymphoceles underwent open marsupialization; 2 with ureteral fistulas underwent reimplantation of the ureter, and the other patient's case required placement of a nephrostomy tube and an antegrade ureteral catheter. All patients were treated successfully. Mean follow-up time of cases with urological complications was 9.5 years. Currently, 60% has nonfunctioning allografts; the mean current glomerular filtration rate of the functioning renal allografts is 55 mL/min. Despite requiring surgical management, all patients were treated successfully. Prompt identification and treatment of any complication are critical for graft and patient survival.

  11. The Prevalence and Characteristic Differences in Prostatic Calcification between Health Promotion Center and Urology Department Outpatients

    OpenAIRE

    Hong, Chan Gyu; Yoon, Byung Il; Choe, Hyun-Sop; Ha, U-Syn; Sohn, Dong Wan; Cho, Yong-Hyun

    2012-01-01

    Purpose We evaluated the differences in calculi characteristics and their prevalence according to the presence of lower urinary tract symptoms between adult patients examined at the Urology Department and those examined at the Health Promotion Center (HPC). Materials and Methods The prevalence of prostatic calcification, characteristics of calculi (number, size, and location), and differences in lower urinary tract symptoms were compared and analyzed for 479 subjects who underwent transrectal...

  12. Prioritizing the patient voice in the development of urologic oncology research.

    Science.gov (United States)

    Filippou, Pauline; Smith, Angela B

    2017-09-01

    Prioritization of patient and stakeholder engagement in the research process has been realized through increased funding and policy directives at the government level. Particularly, patient engagement in the preparatory research stage has driven development of patient-prioritized research questions. In this article, a successful example of patient-centered research prioritization is reviewed, and effective strategies and opportunities for patient engagement in urologic oncology research are described. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. [Urological problems in pregnancy, birth, and puerperium--a systematic review].

    Science.gov (United States)

    Nielsen, Rikke Vibeke; Østergaard, Jeanett; Alling-Møller, Lars

    2012-04-30

    Urological problems in pregnancy represent a diagnostic and therapeutic challenge. Urinary tract symptoms in pregnant women comprise urinary tract infections, urolithiasis, hydronephrosis, urinary retention, urinary frequency and urinary incontinence. The primary purpose of this paper was to link our current understanding of the urinary tract anatomy and physiology to urinary tract symptoms in pregnancy and puerperium and the secondary purpose was to provide a review on diagnosis and management of these.

  14. [International Society of Urological Pathology (ISUP) Consensus Conference on handling and staging of radical prostatectomy specimens].

    Science.gov (United States)

    Compérat, Eva; Camparo, Philippe; Srigley, John; Delahunt, Brett; Egevad, Lars

    2013-06-01

    The 2009 International Society of Urological Pathology (ISUP) consensus conference on handling and staging of radical prostatectomy specimens issued recommendations for standardization of pathology reporting of radical prostatectomy specimens. The conference addressed specimen handling, T2 substaging, prostate cancer volume, extraprostatic extension, lymphovascular invasion, seminal vesicle invasion, lymph node metastases and surgical margins. This review summarizes the conclusions and recommendations resulting from the consensus process. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  15. Selective imaging modalities after first pyelonephritis failed to identify significant urological anomalies, despite normal antenatal ultrasounds

    DEFF Research Database (Denmark)

    Mola, Gylli; Wenger, Therese Ramstad; Salomonsson, Petra

    2017-01-01

    AIM: We investigated the consequences of applying different imaging guidelines for urological anomalies after first pyelonephritis in children with normal routine antenatal ultrasounds. METHODS: The cohort comprised 472 children treated for their first culture-positive pyelonephritis...... identified all patients initially treated with surgery and avoided 65 scintigraphies. CONCLUSION: Dilated VUR was the dominant anomaly in a cohort with first time pyelonephritis and normal antenatal ultrasound. The optimal imaging strategy after pyelonephritis must be identified....

  16. The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies

    Directory of Open Access Journals (Sweden)

    Sato A

    2015-04-01

    Full Text Available Akinori Sato Department of Urology, National Defense Medical College, Tokorozawa, Japan Abstract: The human immunodeficiency virus protease inhibitor ritonavir has recently been shown to have antineoplastic activity, and its use in urological malignancies is under investigation with an eye toward drug repositioning. Ritonavir is thought to exert its antineoplastic activity by inhibiting multiple signaling pathways, including the Akt and nuclear factor-kappaB pathways. It can increase the amount of unfolded proteins in the cell by inhibiting both the proteasome and heat shock protein 90. Combinations of ritonavir with agents that increase the amount of unfolded proteins, such as proteasome inhibitors, histone deacetylase inhibitors, or heat shock protein 90 inhibitors, therefore, induce endoplasmic reticulum stress cooperatively and thereby kill cancer cells effectively. Ritonavir is also a potent cytochrome P450 3A4 and P-glycoprotein inhibitor, increasing the intracellular concentration of combined drugs by inhibiting their degradation and efflux from cancer cells and thereby enhancing their antineoplastic activity. Furthermore, riotnavir’s antineoplastic activity includes modulation of immune system activity. Therapies using ritonavir are thus an attractive new approach to cancer treatment and, due to their novel mechanisms of action, are expected to be effective against malignancies that are refractory to current treatment strategies. Further investigations using ritonavir are expected to find new uses for clinically available drugs in the treatment of urological malignancies as well as many other types of cancer. Keywords: drug repositioning, novel treatment

  17. Biomarker, Molecular, and Technologic Advances in Urologic Pathology, Oncology, and Imaging.

    Science.gov (United States)

    Ellis, Carla L; Harik, Lara R; Cohen, Cynthia; Osunkoya, Adeboye O

    2017-04-01

    Urologic pathology is evolving rapidly. Emerging trends include the expanded diagnostic utility of biomarkers and molecular testing, as well as adapting to the plethora of technical advances occurring in genitourinary oncology, surgical practice, and imaging. We illustrate those trends by highlighting our approach to the diagnostic workup of a few selected disease entities that pathologists may encounter, including newly recognized subtypes of renal cell carcinoma, pheochromocytoma, and prostate cancer, some of which harbor a distinctive chromosomal translocation, gene loss, or mutation. We illustrate applications of immunohistochemistry for differential diagnosis of needle core renal biopsies, intraductal carcinoma of the prostate, and amyloidosis and cite encouraging results from early studies using targeted gene expression panels to predict recurrence after prostate cancer surgery. At our institution, pathologists are working closely with urologic surgeons and interventional radiologists to explore the use of intraoperative frozen sections for margins and nerve sparing during robotic prostatectomy, to pioneer minimally invasive videoscopic inguinal lymphadenectomy, and to refine image-guided needle core biopsies and cryotherapy of prostate cancer as well as blue-light/fluorescence cystoscopy. This collaborative, multidisciplinary approach enhances clinical management and research, and optimizes the care of patients with urologic disorders.

  18. The radius surgical system - a new device for complex minimally invasive procedures in urology?

    Science.gov (United States)

    Frede, Thomas; Hammady, Ahmed; Klein, Jan; Teber, Dogu; Inaki, Noriyuki; Waseda, Masahiro; Buess, Gerhard; Rassweiler, Jens

    2007-04-01

    Complex laparoscopic procedures in urology are technically demanding with an extended learning curve. Robotic systems add significant cost to laparoscopic procedures. We therefore evaluated the use of the Radius Surgical System (RSS), a mechanical manipulator, for complex laparoscopic cases in urology. The RSS (Tuebingen Scientific) consists of two hand-guided surgical manipulators and provides a deflectable and rotatable tip allowing six degrees of freedom. We evaluated the system by using a series of standardized models in the pelvitrainer. We analyzed the effectiveness of the system and the learning curve. We then evaluated the system in the clinical setting during laparoscopic radical prostatectomy. Surgeons with experience on the RSS were compared to surgeons without previous experience on the system. We identified a learning curve in those participants without experience on the system only when performing complete anastomoses in the pelvitrainer. However, this learning curve included less than 10 anastomoses. The first clinical experiences during laparoscopic extraperitoneal radical prostatectomy (n=10) are promising. All anastomoses were patent on routine (X-ray) examination 8 days after surgery. The RSS system is easy to use and we identified a very short learning curve. We now optimize the system for use in urology. This device may facilitate complex laparoscopic procedures without the use of costly robotic systems and should be further evaluated in the experimental and clinical setting.

  19. Soft-tissue applications of the holmium:YAG laser in urology

    Science.gov (United States)

    Denstedt, John D.; Razvi, Hassan A.; Chun, Samuel S.; Sales, Jack L.

    1995-05-01

    The ideal surgical laser for the treatment of soft tissue pathology should possess both ablative and hemostatic abilities. As well, for use in urologic conditions the laser must also be suitable for endoscopic use. The Holmium:YAG laser possesses these qualities and in preliminary clinical use has demonstrated a variety of potential urologic applications. In this study we review our initial experience with the Holmium:YAG laser over a 18 month period. A total of 51 patients underwent 53 procedures for a variety of soft tissue conditions including: bladder tumor ablation (25), incision of ureteral stricture (15), incision of urethral stricture (6), treatment of ureteropelvic junction obstruction (3), incision of bladder neck contracture (2), and ablation of a ureteral tumor (2). Satisfactory hemostasis was achieved in all cases. Procedures were considered successful (no further intervention being required to treat the condition) in 81% of the cases. Two patients with dense bladder neck contractures required electroincision under the same anesthetic for completion of the procedure. A single complication, that of urinary extravasation following incision of a urethral stricture resolved with conservative management. In summary, the Holmium:YAG laser has demonstrated safety and proficiency in the treatment of a variety of urologic soft tissue conditions.

  20. Pediatric urology and the internet--does an uncommon topic decrease content quality?

    Science.gov (United States)

    Routh, Jonathan C; Gong, Edward M; Nelson, Caleb P

    2009-10-01

    The Internet has become a widely used resource for patients and families to obtain medical information but the quality of information available is highly variable. We sought to determine if Web pages addressing common and uncommon pediatric urology topics differ in terms of quality or characteristics. We performed an Internet search using 5 common conditions (vesicoureteral reflux, hypospadias, prenatal hydronephrosis, cryptorchidism, enuresis) and 5 uncommon conditions (exstrophy, prune belly, posterior urethral valves, Wilms tumor, ureterocele). We recorded total hits, presence of sponsored links, page owner and author type, last update, content quality, readability, accreditation and advertising. Content quality was graded on a 5-point scale for accuracy and completeness of natural history, diagnosis and treatment. We evaluated 100 sites on 10 topics. Common topics had more hits (980,000 vs 194,000) and were more likely to have sponsored advertisements (40% vs 0%) than uncommon topics. No difference was seen between topics in time from last update, owner/author type, financial disclosure, accreditation or advertising. Median quality grade was 4.0. Common topics had higher quality grades for disease natural history and diagnosis. Reading grade level was high and was similar between the groups. Web sites devoted to common pediatric urology topics have higher quality information for disease diagnosis and natural history. Otherwise, the quality of pediatric urology information on the Internet is high for common and uncommon topics. A high reading level is required to use these resources.

  1. Social Media in Urology: opportunities, applications, appropriate use and new horizons

    Science.gov (United States)

    Socarrás, Moises Rodríguez; Blanco, Leonardo Tortolero

    2016-01-01

    Introduction Social Media (SoMe) includes a broad spectrum of public use platforms like Twitter, YouTube or Facebook that have changed the way humans interact and communicate. Considering the high usage rates for various SoMe platforms among urologists, we aimed to perform a review regarding opportunities, applications, appropriate use and new horizons of SoMe in urology. Material and methods Literature review. Results We are currently experiencing an explosion in the use of SoMe in healthcare and urology due to the clear offer of advantages in communication, information sharing, enhanced experience of meetings and conferences, as well as, for networking. However, SoMe is an open environment and recommendations should be implemented on the appropriate use in order to respect ethical considerations and not break the harmony of the doctor-patient relationship. SoMe activity has become an important part of our participation in scientific meetings. Conclusions SoMe represents a vibrant area of opportunities for the communication of knowledge in health care and so their potential applications today are unquestionable; however, its development in the urological community is still in its infancy. At present the benefits include communication between associations, urologists, residents, other health care professionals and patients. Further efforts are focusing on standardizing the language used through SoMe and finding out how we can objectively quantify the impact of the information published in SoMe. PMID:27729998

  2. Social Media in Urology: opportunities, applications, appropriate use and new horizons.

    Science.gov (United States)

    Rivas, Juan Gómez; Socarrás, Moises Rodríguez; Blanco, Leonardo Tortolero

    2016-01-01

    Social Media (SoMe) includes a broad spectrum of public use platforms like Twitter, YouTube or Facebook that have changed the way humans interact and communicate. Considering the high usage rates for various SoMe platforms among urologists, we aimed to perform a review regarding opportunities, applications, appropriate use and new horizons of SoMe in urology. Literature review. We are currently experiencing an explosion in the use of SoMe in healthcare and urology due to the clear offer of advantages in communication, information sharing, enhanced experience of meetings and conferences, as well as, for networking. However, SoMe is an open environment and recommendations should be implemented on the appropriate use in order to respect ethical considerations and not break the harmony of the doctor-patient relationship. SoMe activity has become an important part of our participation in scientific meetings. SoMe represents a vibrant area of opportunities for the communication of knowledge in health care and so their potential applications today are unquestionable; however, its development in the urological community is still in its infancy. At present the benefits include communication between associations, urologists, residents, other health care professionals and patients. Further efforts are focusing on standardizing the language used through SoMe and finding out how we can objectively quantify the impact of the information published in SoMe.

  3. Metabolic profiling of cholesterol and sex steroid hormones to monitor urological diseases.

    Science.gov (United States)

    Moon, Ju-Yeun; Choi, Man Ho; Kim, Jayoung

    2016-10-01

    Cholesterol and sex steroid hormones including androgens and estrogens play a critical role in the development and progression of urological diseases such as prostate cancer. This disease remains the most commonly diagnosed malignant tumor in men and is the leading cause of death from different cancers. Attempts to understand the role of cholesterol and steroid metabolism in urological diseases have been ongoing for many years, but despite this, our mechanistic and translational understanding remains elusive. In order to further evaluate the problem, we have taken an interest in metabolomics; a discipline dedicated to the systematic study of biologically active metabolites in cells, tissues, hair and biofluids. Recently, we provided evidence that a quantitative measurement of cholesterol and sex steroid metabolites can be successfully achieved using hair of human and mouse models. The overall goal of this short review article is to introduce current metabolomic technologies for the quantitative biomarker assay development and also to provide new insight into understanding the underlying mechanisms that trigger the pathological condition. Furthermore, this review will place a particular emphasis on how to prepare biospecimens (e.g., hair fiber), quantify molecular profiles and assess their clinical significance in various urological diseases.

  4. Evaluating the definition of "stone free status" in contemporary urologic literature.

    Science.gov (United States)

    Deters, L A; Jumper, C M; Steinberg, P L; Pais, V M

    2011-11-01

    There is no standardized definition of stone free after renal stone surgery. The lack of standardization prompted a review of the current urologic literature, to assess the definitions of stone free status, and how imaging is used to determine stone free status. A literature search on PubMed for the MeSH terms for percutaneous nephrolithotomy (PCNL), ureteroscopy with lithotripsy, shock wave lithotripsy (SWL), and laser lithotripsy, published in English between January 2007 and January 2010 was performed. Case reports, articles not evaluating stone free outcomes, and review articles were excluded. Articles were evaluated for the treatment modality, definition of stone free status, and the imaging modality employed to determine stone free status. This search yielded 417 articles of which 249 met inclusion criteria. Stone free was defined in 169 articles (68%). The most common definition of stone free was "no stones" (47%), but a total of seven different definitions were encountered. The most common treatment modality was PCNL (47%), followed by SWL (33%), and URS (13%). The most common detection modality was KUB alone (28%), the second most common being KUB and US combined (22%). Nearly one-third of articles evaluating surgical management of urinary calculi do not define stone free status; when stone free is defined, there is wide variation as to that definition. Furthermore, vast differences exist in the type of imaging used to define stone free status. The urologic community should standardize the reporting of stone free outcomes in the urologic literature.

  5. The European Association of Urology (EAU) guidelines methodology: a critical evaluation.

    Science.gov (United States)

    Aus, Gunnar; Chapple, Christopher; Hanûs, Tomas; Irani, Jacques; Lobel, Bernard; Loch, Tillmann; Mitropoulos, Dionysios; Parsons, Keith; Plass, Karin; Schmid, Hans-Peter

    2009-11-01

    Guidelines can be produced and written in numerous ways. The aim of the present article is to describe and evaluate the method currently used to produce the European Association of Urology (EAU) guidelines. The methodology is described in detail, compared to other urologic guidelines by members of the EAU Guidelines Office Board. The new methodology is evaluated by the Appraisal of Guidelines for Research and Evaluation (AGREE) instrument. The currently used methodology is adapted to the aims and objectives as established by the EAU for their guidelines; wide coverage (essentially all fields of urology) and useful to urologists all over Europe. The frequent updates are easily accessible in a printed and electronic format. The AGREE instrument supports these strong points, but also identifies potentially weak points, such as no patient involvement, no formal validation of the guidelines texts prior to publication, and lack of discussion of organisational barriers and cost implications. The currently used methodology for the production of EAU guidelines fulfils the association's main objectives related to their guidelines, but the texts will benefit from the inclusion of country-specific cost and organisational data. For the practising clinician, these guidelines will help to take science into clinical practice.

  6. Reclutamento e formazione dei poliziotti: il caso degli ufficiali della gendarmeria francese

    Directory of Open Access Journals (Sweden)

    François Dieu

    2007-04-01

    Full Text Available Partendo dal caso degli ufficiali della gendarmeria francese, questo articolo illustra il modo in cui il reclutamento e la formazione possono contribuire, informalmente, alla ripartizione del potere nelle organizzazioni di polizia. Tramite la diversità delle vie di reclutamento si costituisce, di fatto, un vero e proprio sistema di "caste", con una stratificazione degli ufficiali in tre livelli gerarchici, che produce, al di là dei principi meritocratici, delle ineguaglianze manifeste nella ripartizione del potere nell'organizzazione della gendarmeria.

  7. The effect of social media (#SoMe) on journal impact factor and parental awareness in paediatric urology.

    Science.gov (United States)

    O'Kelly, F; Nason, G J; Manecksha, R P; Cascio, S; Quinn, F J; Leonard, M; Koyle, M A; Farhat, W; Leveridge, M J

    2017-04-21

    Social media (SoMe) comprises a number of internet-based applications that have the capability to disseminate multimodal media and allow for unprecedented inter-user connectivity. The role of Twitter has been studied in conferences and education; moreover, there is increasing evidence that patients are more likely to use social media for their own health education. The aim of this study was to assess the impact of social media platforms on the impact factor of both urological and paediatric journals that publish on paediatric urology, and to assess parental awareness of social media in paediatric urology. A filtered Journal of Citation Reports (JCR) search was performed for the period 2012-16 for journals that published articles on paediatric urology. Journals were ranked according to impact factor, and each individual journal website was accessed to assess for the presence of social media. Parents in paediatric urology clinics and non-paediatric urology patients also filled out a questionnaire to assess for awareness and attitudes to social media. All statistical analysis was performed using Prism 6 software (Prism 6, GraphPad Software, California, USA). Overall, there were 50 urological journals and 39 paediatric journals with a mean impact factor of 2.303 and 1.766, respectively. There was an overall average increase in impact factor across all urological journals between 2012 and 16. The presence of a Twitter feed was statistically significant for a rise in impact factor over the 4 years (P = 0.017). The cohort of parents was statistically more likely to have completed post-secondary education, to have and access to a social media profile, use it for health education, and use it to access journal/physician/hospital social media accounts. This study examined, for the first time, the role of social media in paediatric urology, and demonstrated that SoMe use is associated with a positive influence in impact factor, but also a parental appetite for it

  8. Methodological Quality of Systematic Reviews Published in the Urological Literature from 1998 to 2012.

    Science.gov (United States)

    Corbyons, Katherine; Han, Julia; Neuberger, Molly M; Dahm, Philipp

    2015-11-01

    Systematic reviews synthesize the current best evidence to address a clinical question. Given the growing emphasis on evidence-based clinical practice, systematic reviews are being increasingly sought after and published. We previously reported limitations in the methodological quality of 57 individual systematic reviews published from 1998 to 2008. We provide an update to our previous study, adding systematic reviews published from 2009 to 2012. We systematically searched PubMed® and hand searched the table of contents of 4 major urological journals to identify systematic reviews related to questions of prevention and therapy. Two independent reviewers with prior formal evidence-based medicine training assessed the methodological quality using the validated 11-point AMSTAR (A Measurement Tool to Assess Systematic Reviews) instrument. We performed predefined statistical hypothesis testing for differences by publication period (1998 to 2008 vs 2009 to 2012) and journal of publication. We performed statistical testing using SPSS®, version 23.0 with a 2-sided α of 0.05 using the Student t-test, ANOVA and the chi-square test. A total of 113 systematic reviews published from 2009 to 2012 met study inclusion criteria. The most common topics were oncology (44 reviews or 38.9%), voiding dysfunction (26 or 23.0%) and stones/endourology (13 or 11.5%). The largest contributor was European Urology (46 reviews or 40.7%), followed by BJU International (31 or 27.4%) and The Journal of Urology® (22 or 19.5%). The mean ± SD AMSTAR score for the 2009 to 2012 period was 5.3 ± 2.3 compared to 4.8 ± 2.0 for 1998 to 2008 with a mean difference of 0.5 (95% CI 0.2 to 1.2, p = 0.133). While the number of systematic reviews published in the urological literature has increased substantially, the methodological quality of these studies remains suboptimal. Systematic review authors and editors should make every effort to adhere to well established methodological standards to enhance

  9. Degradation of PsbO by the Deg protease HhoA Is thioredoxin dependent.

    Directory of Open Access Journals (Sweden)

    Irma N Roberts

    Full Text Available The widely distributed members of the Deg/HtrA protease family play an important role in the proteolysis of misfolded and damaged proteins. Here we show that the Deg protease rHhoA is able to degrade PsbO, the extrinsic protein of the Photosystem II (PSII oxygen-evolving complex in Synechocystis sp. PCC 6803 and in spinach. PsbO is known to be stable in its oxidized form, but after reduction by thioredoxin it became a substrate for recombinant HhoA (rHhoA. rHhoA cleaved reduced eukaryotic (specifically, spinach PsbO at defined sites and created distinct PsbO fragments that were not further degraded. As for the corresponding prokaryotic substrate (reduced PsbO of Synechocystis sp. PCC 6803, no PsbO fragments were observed. Assembly to PSII protected PsbO from degradation. For Synechocystis sp. PCC 6803, our results show that HhoA, HhoB, and HtrA are localized in the periplasma and/or at the thylakoid membrane. In agreement with the idea that PsbO could be a physiological substrate for Deg proteases, part of the cellular fraction of the three Deg proteases of Synechocystis sp. PCC 6803 (HhoA, HhoB, and HtrA was detected in the PSII-enriched membrane fraction.

  10. The air oxidation behavior of lanthanum ion implanted zirconium at 500 deg. C

    CERN Document Server

    Peng, D Q; Chen, X W; Zhou, Q G

    2003-01-01

    The beneficial effect of lanthanum ion implantation on the oxidation behavior of zirconium at 500 deg. C has been studied. Zirconium specimens were implanted by lanthanum ions using a MEVVA source at energy of 40 keV with a fluence range from 1x10 sup 1 sup 6 to 1x10 sup 1 sup 7 ions/cm sup 2 at maximum temperature of 130 deg. C, The weight gain curves were measured after being oxidized in air at 500 deg. C for 100 min, which showed that a significant improvement was achieved in the oxidation behavior of zirconium ion implanted with lanthanum compared with that of the as-received zirconium. The valence of the oxides in the scale was analyzed by X-ray photoemission spectroscopy; and then the depth distributions of the elements in the surface of the samples were obtained by Auger electron spectroscopy. Glancing angle X-ray diffraction at 0.3 deg. incident angles was employed to examine the modification of its phase transformation because of the lanthanum ion implantation in the oxide films. It was obviously fou...

  11. Exploring a possible origin of a 14 deg y-normal spin tilt at RHIC polarimeter

    Energy Technology Data Exchange (ETDEWEB)

    Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Huang, H. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-06-15

    A possible origin of a 14 deg y-normal spin n0 tilt at the polarimeter is in snake angle defects. This possible cause is investigated by scanning the snake axis angle µ, and the spin rotation angle at the snake, φ, in the vicinity of their nominal values.

  12. A Byzantine chant collection from Sicily: a collaboration between Copenhagen and Piana degli Albanesi (Palermo)

    DEFF Research Database (Denmark)

    Sanfratello, Giuseppe

    2016-01-01

    The aim of this paper is to give an account of the collaboration between a collector of the Byzantine chant tradition of Piana degli Albanesi (Palermo) in Sicily, namely fr. Bartolomeo Di Salvo, and the editorial board of the Monumenta Musicae Byzantinae, i.e. an institution under the aegis......, Collections, Ethnomusicology, Critical edition, Monumenta Musicae Byzantinae (MMB)...

  13. Phosphorylation of DegU is essential for activation of amyE expression in Bacillus subtilis

    Indian Academy of Sciences (India)

    Monica Gupta; K Krishnamurthy Rao

    2014-12-01

    Alpha ()-amylase (amyE) is one of the major exo-enzymes secreted by Bacillus subtilis during the post-exponential phase. The DegS-DegU two-component system regulates expression of majority of post-exponentially expressed genes in B. subtilis. It has been demonstrated that varying levels of the phosphorylated form of DegU (DegU-P) control different cellular processes. Exo-protease production is observed when effective concentration of DegU-P rises in the cell, whereas swarming motility is favoured at very low amounts of DegU-P. In this study we show that like other exo-proteases, expression of amyE is positively regulated by increase in DegU-P levels in the cell. We also demonstrate that residues at the DNA-binding helix-turn-helix (HTH) motif of DegU are necessary for the amyE expression. This observation is further reinforced by demonstrating the direct interaction of DegU on amyE promoter.

  14. AromaDeg, a novel database for phylogenomics of aerobic bacterial degradation of aromatics.

    Science.gov (United States)

    Duarte, Márcia; Jauregui, Ruy; Vilchez-Vargas, Ramiro; Junca, Howard; Pieper, Dietmar H

    2014-01-01

    Understanding prokaryotic transformation of recalcitrant pollutants and the in-situ metabolic nets require the integration of massive amounts of biological data. Decades of biochemical studies together with novel next-generation sequencing data have exponentially increased information on aerobic aromatic degradation pathways. However, the majority of protein sequences in public databases have not been experimentally characterized and homology-based methods are still the most routinely used approach to assign protein function, allowing the propagation of misannotations. AromaDeg is a web-based resource targeting aerobic degradation of aromatics that comprises recently updated (September 2013) and manually curated databases constructed based on a phylogenomic approach. Grounded in phylogenetic analyses of protein sequences of key catabolic protein families and of proteins of documented function, AromaDeg allows query and data mining of novel genomic, metagenomic or metatranscriptomic data sets. Essentially, each query sequence that match a given protein family of AromaDeg is associated to a specific cluster of a given phylogenetic tree and further function annotation and/or substrate specificity may be inferred from the neighboring cluster members with experimentally validated function. This allows a detailed characterization of individual protein superfamilies as well as high-throughput functional classifications. Thus, AromaDeg addresses the deficiencies of homology-based protein function prediction, combining phylogenetic tree construction and integration of experimental data to obtain more accurate annotations of new biological data related to aerobic aromatic biodegradation pathways. We pursue in future the expansion of AromaDeg to other enzyme families involved in aromatic degradation and its regular update. Database URL: http://aromadeg.siona.helmholtz-hzi.de

  15. Hi-GAL, the Herschel infrared Galactic Plane Survey: photometric maps and compact source catalogues. First data release for Inner Milky Way: +68{\\deg}> l > -70{\\deg}

    CERN Document Server

    Molinari, S; Elia, D; Pestalozzi, M; Traficante, A; Pezzuto, S; Swinyard, B M; Noriega-Crespo, A; Bally, J; Moore, T J T; Plume, R; Zavagno, A; di Giorgio, A M; Liu, S J; Pilbratt, G L; Mottram, J C; Russeil, D; Piazzo, L; Veneziani, M; Benedettini, M; Calzoletti, L; Faustini, F; Natoli, P; Piacentini, F; Merello, M; Palmese, A; Del Grande, R; Polychroni, D; Rygl, K L J; Polenta, G; Barlow, M J; Bernard, J -P; Martin, P G; Testi, L; Ali, B; Andrè, P; Beltrán, M T; Billot, N; Brunt, C; Carey, S; Cesaroni, R; Compiègne, M; Eden, D; Fukui, Y; Garcia-Lario, P; Hoare, M G; Huang, M; Joncas, G; Lim, T L; Lord, S D; Martinavarro-Armengol, S; Motte, F; Paladini, R; Paradis, D; Peretto, N; Robitaille, T; Schilke, P; Schneider, N; Schulz, B; Sibthorpe, B; Strafella, F; Thompson, M A; Umana, G; Ward-Thompson, D; Wyrowski, F

    2016-01-01

    (Abridged) We present the first public release of high-quality data products (DR1) from Hi-GAL, the {\\em Herschel} infrared Galactic Plane Survey. Hi-GAL is the keystone of a suite of continuum Galactic Plane surveys from the near-IR to the radio, and covers five wavebands at 70, 160, 250, 350 and 500 micron, encompassing the peak of the spectral energy distribution of cold dust for 8 l > -70{\\deg} in a |b|<1{\\deg} latitude strip. Photometric maps have been produced with the ROMAGAL pipeline, that optimally capitalizes on the excellent sensitivity and stability of the bolometer arrays of the {\\em Herschel} PACS and SPIRE photometric cameras, to deliver images of exquisite quality and dynamical range, absolutely calibrated with {\\em Planck} and {\\em IRAS}, and recovering extended emission at all wavelengths and all spatial scales. The compact source catalogues have been generated with the CuTEx algorithm, specifically developed to optimize source detection and extraction in the extreme conditions of intens...

  16. Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel.

    Science.gov (United States)

    Köves, Bela; Cai, Tommaso; Veeratterapillay, Rajan; Pickard, Robert; Seisen, Thomas; Lam, Thomas B; Yuan, Cathy Yuhong; Bruyere, Franck; Wagenlehner, Florian; Bartoletti, Riccardo; Geerlings, Suzanne E; Pilatz, Adrian; Pradere, Benjamin; Hofmann, Fabian; Bonkat, Gernot; Wullt, Björn

    2017-07-25

    People with asymptomatic bacteriuria (ABU) are often unnecessarily treated with antibiotics risking adverse effects and antimicrobial resistance. We performed a systematic review to determine any benefits and harms of treating ABU in particular patient groups. Relevant databases were searched and eligible trials were assessed for risk-of-bias and Grading of Recommendations, Assessment, Development and Education quality. Where possible, a meta-analysis of extracted data was performed or a narrative synthesis of the evidence was presented. After screening 3626 articles, 50 studies involving 7088 patients were included. Overall, quality of evidence ranged from very low to low. There was no evidence of benefit for patients with no risk factors, patients with diabetes mellitus, postmenopausal women, elderly institutionalised patients, patients with renal transplants, or patients prior to joint replacement, and treatment was harmful for patients with recurrent urinary tract infection (UTI). Treatment of ABU resulted in a lower risk of postoperative UTI after transurethral resection surgery. In pregnant women, we found evidence that treatment of ABU decreased risk of symptomatic UTI, low birthweight, and preterm delivery. ABU should be treated prior to transurethral resection surgery. In addition, current evidence also suggests that ABU treatment is required in pregnant women, although the results of a recent trial have challenged this view. We reviewed available scientific studies to see if people with bacteria in their urine but without symptoms of urinary tract infection should be treated with antibiotics to eliminate bacteria. For most people, treatment was not beneficial and may be harmful. Antibiotic treatment did appear to benefit women in pregnancy and those about to undergo urological surgery. Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  17. Environmental fatigue behaviors of wrought and cast stainless steels in 310 .deg. C Deoxygenated Water

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Pyung Yeon

    2011-02-15

    Environmental fatigue behaviors of wrought type 316LN stainless steel and cast CF8M stainless steel were investigated. LCF tests were performed at fixed strain rate of 0.04%/s with 0.4%, 0.6%, 0.8%, 1.0% strain amplitudes in 310 .deg. C deoxygenated water environment. In addition, to analyze microstructure effect on fatigue behavior, low cycle fatigue tests in air environment were performed at fixed strain rate of 0.4%/s, 0.04%/s with 0.4%, 0.8% strain amplitudes. It was shown that the low cycle fatigue life of CF8M in a 310 .deg. C deoxygenated water environment was slightly longer than that of 316LN. On the other hand, the low cycle fatigue life of CF8M in a 310 .deg. C air environment was slightly shorter than that of 316LN or was similar with that of 316LN. Through OM observation and phase image analysis, it was confirmed that the ferrite content of CF8M tested in a 310 .deg. C deoxygenated water environment was larger than that of CF8M tested in a 310 .deg. C air environment. It was shown that the ferrite phase fraction of CF8M tested in 310 .deg. C deoxygenated water environment was approximately 26∼28% and that of CF8M tested in air environment was approximately 10∼12%. The difference of ferrite content in CF8M results in superior tensile properties as higher ferrite content. Furthermore, the difference of ferrite content in CF8M might be the cause of different result of fatigue life between CF8M and 316LN depending on environment. In this study, focused on CF8M having 26∼28% ferrite content, to understand the causes of these differences in a 310 .deg. C deoxygenated water environment, fracture surface and crack morphology were observed. And material factors like microstructure, mechanical properties factors like stress behavior during fatigue life, factors by environmentally assisted cracking (EAC) like hydrogen induced cracking (HIC) and chemical compositions of both materials were analyzed. Mainly in a 310 .deg. C deoxygenated water environment, the

  18. Wind-tunnel force and flow visualization data at Mach numbers from 1.6 to 4.63 for a series of bodies of revolution at angles of attack from minus 4 deg to 60 deg

    Science.gov (United States)

    Landrum, E. J.; Babb, C. D.

    1979-01-01

    Flow visualization and force data for a series of six bodies of revolution are presented without analysis. The data were obtained in the Langley Unitary Plan wind tunnel for angles of attack from -4 deg to 60 deg. The Reynolds number used for these tests was 6,600,000 per meter.

  19. [Andres Vesalio, Francisco Díaz, Miguel de Cervantes Saavedra and the birth of urology in the 16th Century].

    Science.gov (United States)

    Carrillo Esper, Raúl; Carrillo Córdova, Luis Daniel; Carrillo Córdova, Dulce María; Carrillo Córdova, Carlos Alberto; Carrillo Córdova, Jorge Raúl

    2015-01-01

    In the sixteenth century there were great advances in science, literature, and the arts. During this century, urology as a specialty was conceived, thanks to the contributions of Andreas Vesalius, anatomist and leading physician to the court of Charles V, and Dr. Francisco Diaz, a native of Alcala de Henares, surgeon and clinician. Dr. Diaz had a close relationship with Miguel de Cervantes, who at one point in his life suffered from renal colic. In his masterpiece "Re-Printed Treaty of all diseases of the kidneys, bladder and wattles of the Cock and Urina, divided into three books," of which the first book of urology is the History of Medicine, describes in detail the clinical and therapeutic aspects of urological diseases, known as the "bad stone" and urethral strictures known as "wattles", in addition to describing the different surgical techniques and the development of new instruments for urological procedures, which include the cisorio instrument and the Speculum pudendi. For the above, Dr. Francisco Diaz is considered the father of urology.

  20. [Archivos Españoles de Urología. Enrique Pérez Castro's direction (1944-1980)].

    Science.gov (United States)

    Albacete, Mariano Pérez

    2008-01-01

    With the occasion of the centenary of the birth of Dr. Enrique Pérez Castro, founder, first director and editor of the journal Archivos Españoles de Urología, at this time when the issue No. 61 comes out, we performed a historic study of the evolution of the journal throughout the 36 years it was ruled by him, between April 1944 and December 1980. Complete review of the 158 issues, together with three extraordinary issues, included in the 31 volumes edited in the period Dr. Pérez Castro directed it. The journal, senior journal in Spanish Urology, developed its main objective of being the communication and knowledge exchange media, with the exposition of scientific works, among the members of the Spanish urological community who admitted it with interest and complete acceptation. The work and devotion of Dr. Pérez Castro as director conferred the journal a great quality and achieved to join it to the Spanish Association of Urology, which demonstrated its category and reinforced its diffusion, acceptation and continuity. It is by itself an exceptional document and splendid historic synopsis of our urology over the second half of the 20th century.

  1. Update on Urological Management of Spina Bifida from Prenatal Diagnosis to Adulthood.

    Science.gov (United States)

    Snow-Lisy, Devon C; Yerkes, Elizabeth B; Cheng, Earl Y

    2015-08-01

    We review the current literature regarding urological management of spina bifida from prenatal diagnosis to adulthood. We searched MEDLINE(®), EMBASE(®) and PubMed(®) for English articles published through December 2014 using search terms "spina bifida," "spinal dysraphism" and "bladder." Based on review of titles and abstracts, 437 of 1,869 articles were identified as addressing topics related to open spina bifida in pediatric patients, or long-term or quality of life outcomes in adults with spina bifida. We summarize this literature to inform clinical guidelines and create a framework for disease management. The birth prevalence of spina bifida in the United States has recently plateaued at approximately 30 per 100,000. With improved management more individuals are surviving to adulthood, with an economic impact of $319,000 during the lifetime of an individual with spina bifida. Recent advances in prenatal surgery have demonstrated that prenatal closure of spina bifida is possible. To assess safety and efficacy, the National Institutes of Health sponsored Management of Myelomeningocele Study was undertaken, in which subjects were randomized to prenatal or postnatal closure. Until the urological results of this trial are published, the impact of prenatal intervention on future bladder function remains unclear. Controversy continues regarding the optimal use and timing of urodynamic studies, and the indications for initiation of clean intermittent catheterization and anticholinergics in infants and children. Many favor expectant management, while others argue for a more proactive approach. Based on the current literature, both approaches appear to protect the child from renal injury, although delayed intervention may increase rates of bladder augmentation. The current literature regarding this topic is difficult to interpret and compare due to heterogeneity of patient populations, variable outcome measures and lack of reporting of quality of life outcomes

  2. Pourbaix diagrams for the system copper-chlorine at 5-100 deg C

    Energy Technology Data Exchange (ETDEWEB)

    Beverskog, B. [Studsvik Material AB, Nykoeping (Sweden); Puigdomenech, I. [Studsvik Eco and Safety AB, Nykoeping (Sweden)

    1998-04-01

    Pourbaix diagrams for the copper-chlorine system in the temperature interval 5-100 deg C have been revised. Predominance diagrams for dissolved copper containing species have also been calculated. Two different total concentrations of each dissolved element, 10{sup -4} and 10{sup -6} molal for copper and 0.2 and 1.5 molal for chlorine have been used in the calculations. Chloride is the predominating chlorine species in aqueous solutions. Presence of chloride increases the corrosion regions of copper at the expense of the immunity and passivity regions in the Pourbaix diagrams. CuCl{sub 2} {center_dot} 3Cu(OH){sub 2} is the only copper-chloride solid phase that forms at the concentrations of chlorine studied. However, its stability area decreases with increasing temperature. The ion CuCl{sub 2}{sup -} predominates at all temperatures at [Cl(aq)]{sub tot}=0.2 molal and this reduces the immunity and passivity areas. A corrosion region exists between the immunity and passivity regions at 100 deg C at [Cu(aq)]{sub tot}=10{sup -6} and [Cl(aq)]{sub tot}=0.2 molal. At the chlorine concentration of 1.5 molal the corrosion region exists in the whole temperature range investigated. The ion CuCl{sub 3}{sup 2-} predominates at 5-25 and 100 deg C, while CuCl{sub 2}{sup -} predominates at 50-80 deg C at [Cl(aq)]{sub tot=}1-5 molal. A copper concentration of 10{sup -4} molal reduces the corrosion areas due to expansion of the immunity and passivity areas. However, a corrosion region still exists between the immunity and passivity regions at all investigated temperatures at pH{sub {Tau}}<9.5 and 1.5 molal chloride concentration. According to our calculations the copper canisters in the deep nuclear waste repository should not corrode at the copper concentration of 10{sup -6} molal and the chloride concentration of 0.2 molal. However, at 80-100 deg C the equilibrium potentials postulated for the Swedish nuclear repository are dangerously close to a corrosion situation. According to

  3. Book review, Igiene e Tecnologie degli Alimenti di Origine Animale Giampaolo Colavita (a cura di

    Directory of Open Access Journals (Sweden)

    Manuel Graziani

    2008-09-01

    Full Text Available Igiene e Tecnologie degli Alimenti di Origine Animale si avvale del contributo di 33 autori, tutti soci dell’Associazione Italiana Veterinari Igienisti (AIVI, che garantiscono l’appropriata trattazione di una materia estremamente vasta e dinamica. Il manuale nasce da un’iniziativa finalizzata alla realizzazione di un testo che rifletta e possa soddisfare le esigenze didattiche degli insegnamenti di un’ampia serie di materie universitarie: Igiene e Tecnologie degli Alimenti di Origine Animale della Facoltà di Medicina Veterinaria, di Agraria, nei corsi di Scienze e Tecnologie Alimentari, di Scienze e Tecnologie delle Produzioni Animali, nel corso di laurea in Tecniche della Prevenzione nell’ambiente e nei Luoghi di Lavoro, nonché in altri corsi di studio dove si insegnano le discipline relative all’igiene e alla sicurezza degli alimenti.Sono stati trattati gran parte degli alimenti di origine animale, i prodotti a base di carne, il latte e i prodotti derivati, i prodotti della pesca freschi e trasformati, i prodotti dell’alveare, le uova e gli ovoprodotti. Di particolare interesse appare il capitolo riguardante la diagnostica analitica degli alimenti, considerato che le moderne metodologie analitiche risultano fondamentali per affrontare le tematiche legate all’igiene e alla sicurezza alimentare.Il volume ha una finalità prevalentemente didattica ma è comunque rivolto a tutti coloro che operano nel campo dell’Igiene e delle Tecnologie Alimentari. Infatti, visti gli argomenti trattati come le tossinfezioni e le intossicazioni alimentari, la conservazione, il confezionamento e l’etichettatura dei prodotti alimentari, anche i professionisti del settore possono trarre dal testo elementi utili per la loro attività. Per esempio argomenti quali l’analisi del rischio, le attività di audit ed i sistemi di accreditamento e di certificazione sono particolarmente utili per chi opera nelle Aziende Sanitarie Locali e negli Istituti

  4. Prevalence of Research Publication Misrepresentation Among Urology Residency Applicants and Its Effect on Match Success.

    Science.gov (United States)

    Pak, Jamie S; Pagano, Matthew J; Cooper, Kimberly L; McKiernan, James M; Badalato, Gina M

    2017-01-01

    To report the prevalence of research misrepresentation among urology residency applicants and assess its effect on match success. All applications to the Columbia University urology residency program for the 2014-2015 match cycle were reviewed. "In-press," "accepted," and "submitted" manuscripts were verified using PubMed, Google Scholar, and journal websites. Misrepresentation for "in-press" and "accepted" manuscripts was defined as: (1) nonexistent manuscript, (2) nonauthorship of existent manuscript, (3) self-promotion to a higher author rank, and/or (4) existent manuscript in a nonpeer-reviewed publication. Logistic regression was performed to identify associated factors of misrepresentation and of match success. Of 257 applicants, 204 (79.4%) reported 1098 total manuscripts and 142 (55.3%) reported 371 unpublished manuscripts. About 5% (13 of 257) of applicants misrepresented 1 or more publications: 10 listed nonexistent manuscripts, 1 listed a publication for which he/she was listed a lower author rank than reported, 1 listed an accepted manuscript in a nonpeer-reviewed publication and for which he/she was not listed as an author, and 1 listed 4 in-press manuscripts in a nonpeer-reviewed publication. Only 55.8% (139 of 249) of "submitted" manuscripts were published within 12 months, with 41% (51 of 139) published in a journal of a lower impact factor than the reported journal of submission. Higher number of unpublished manuscripts was associated with misrepresentation. Higher Step 1 score, number of away sub-internships, and publication ratio were associated with match success. Research misrepresentation is a persistent issue in urology residency applications. However, misrepresentation in this cohort did not confer a significant advantage in match success. Published by Elsevier Inc.

  5. Are urological procedures in tetraplegic patients safely performed without anesthesia? a report of three cases

    Directory of Open Access Journals (Sweden)

    Vaidyanathan Subramanian

    2012-02-01

    Full Text Available Abstract Background Some tetraplegic patients may wish to undergo urological procedures without anaesthesia, but these patients can develop autonomic dysreflexia if cystoscopy and vesical lithotripsy are performed without anaesthesia. Case presentation We describe three tetraplegic patients, who developed autonomic dysreflexia when cystoscopy and laser lithotripsy were carried out without anesthesia. In two patients, who declined anaesthesia, blood pressure increased to more than 200/110 mmHg during cystoscopy. One of these patients developed severe bleeding from bladder mucosa and lithotripsy was abandoned. Laser lithotripsy was carried out under subarachnoid block a week later in this patient, and this patient did not develop autonomic dysreflexia. The third patient with C-3 tetraplegia had undergone correction of kyphoscoliotic deformity of spine with spinal rods and pedicular screws from the level of T-2 to S-2. Pulmonary function test revealed moderate to severe restricted curve. This patient developed vesical calculus and did not wish to have general anaesthesia because of possible need for respiratory support post-operatively. Subarachnoid block was not considered in view of previous spinal fixation. When cystoscopy and laser lithotripsy were carried out under sedation, blood pressure increased from 110/50 mmHg to 160/80 mmHg. Conclusion These cases show that tetraplegic patients are likely to develop autonomic dysreflexia during cystoscopy and vesical lithotripsy, performed without anaesthesia. Health professionals should educate spinal cord injury patients regarding risks of autonomic dysreflexia, when urological procedures are carried out without anaesthesia. If spinal cord injury patients are made aware of potentially life-threatening complications of autonomic dysreflexia, they are less likely to decline anaesthesia for urological procedures. Subrachnoid block or epidural meperidine blocks nociceptive impulses from urinary bladder

  6. Variation in Surgical Antibiotic Prophylaxis for Outpatient Pediatric Urological Procedures at United States Children's Hospitals.

    Science.gov (United States)

    Chan, Katherine H; Bell, Teresa; Cain, Mark; Carroll, Aaron; Benneyworth, Brian D

    2017-03-01

    Guidelines recommend surgical antibiotic prophylaxis for clean-contaminated procedures but none for clean procedures. The purpose of this study was to describe variations in surgical antibiotic prophylaxis for outpatient urological procedures at United States children's hospitals. Using the PHIS (Pediatric Health Information System®) database we performed a retrospective cohort study of patients younger than 18 years who underwent clean and/or clean-contaminated outpatient urological procedures from 2012 to 2014. We excluded those with concurrent nonurological procedures or an abscess/infected wound. We compared perioperative antibiotic charges for clean vs clean-contaminated procedures using a multilevel logistic regression model with a random effect for hospital. We also examined whether hospitals that were guideline compliant for clean procedures, defined as no surgical antibiotic prophylaxis, were also compliant for clean-contaminated procedures using the Pearson correlation coefficient. We examined hospital level variation in antibiotic rates using the coefficient of variation. A total of 131,256 patients with a median age of 34 months at 39 hospitals met study inclusion criteria. Patients undergoing clean procedures were 14% less likely to receive guideline compliant surgical antibiotic prophylaxis than patients undergoing clean-contaminated procedures (OR 0.86, 95% CI 0.84-0.88, p variation was seen for hospital level compliance with surgical antibiotic prophylaxis for clean-contaminated procedures (range 9.8% to 97.8%, coefficient of variation 0.36) than for clean procedures (range 35.0% to 98.2%, coefficient of variation 0.20). Hospitals that used surgical antibiotic prophylaxis appropriately for clean-contaminated procedures were likely to use surgical antibiotic prophylaxis inappropriately for clean procedures. More variation was seen in hospital level guideline compliance for clean-contaminated procedures. Copyright © 2017 American Urological

  7. Using an abdominal phantom to teach urology residents ultrasound-guided percutaneous needle placement

    Directory of Open Access Journals (Sweden)

    Pauline Filippou

    Full Text Available ABSTRACT Introduction: To assess the effect of a hands-on ultrasound training session to teach urologic trainees ultrasound-guided percutaneous needle placement. Materials and methods: University of California, San Francisco (UCSF urology residents completed a time trial, placing a needle into a phantom model target under ultrasound guidance. Participants were randomized into three educational exposure groups: Group 1's time trial occurred prior to any teaching intervention, group 2's after experiencing a hands-on training module, and group 3's after exposure to both the training module and one-on-one attending feedback. Needle placement speed and accuracy as well as trainees' perceived confidence in utilizing ultrasound were measured. Results: The study cohort consisted of 15 resident trainees. Seven were randomized to group 1, three to group 2, and five to group 3. All residents reported minimal prior ultrasound experience. Their confidence in using ultrasound improved significantly after completing the training module with the most significant improvement seen among junior residents. Time to needle placement was fastest after receiving attending feedback (46.6sec in group 3 vs. 82.7sec in groups 1 and 2, p<0.01. Accuracy also improved with attending feedback, though the number of repositioning attempts did not differ significantly between groups. Conclusions: A hands-on training module and use of an abdominal phantom trainer increased resident confidence and skill in their use of ultrasound to guide percutaneous needle positioning. Attending feedback is critical for improving accuracy in needle guidance toward a target. Ultrasound-guided needle positioning is a teachable skill and can be applicable to multiple urologic procedures.

  8. Evaluation of Prostate Cancer Risk Calculators for Shared Decision Making Across Diverse Urology Practices in Michigan.

    Science.gov (United States)

    Auffenberg, Gregory B; Merdan, Selin; Miller, David C; Singh, Karandeep; Stockton, Benjamin R; Ghani, Khurshid R; Denton, Brian T

    2017-06-01

    To compare the predictive performance of a logistic regression model developed with contemporary data from a diverse group of urology practices to that of the Prostate Cancer Prevention Trial (PCPT) Risk Calculator version 2.0. With data from all first-time prostate biopsies performed between January 2012 and March 2015 across the Michigan Urological Surgery Improvement Collaborative (MUSIC), we developed a multinomial logistic regression model to predict the likelihood of finding high-grade cancer (Gleason score ≥7), low-grade cancer (Gleason score ≤6), or no cancer on prostate biopsy. The performance of the MUSIC model was evaluated in out-of-sample data using 10-fold cross-validation. Discrimination and calibration statistics were used to compare the performance of the MUSIC model to that of the PCPT risk calculator in the MUSIC cohort. Of the 11,809 biopsies included, 4289 (36.3%) revealed high-grade cancer; 2027 (17.2%) revealed low-grade cancer; and the remaining 5493 (46.5%) were negative. In the MUSIC model, prostate-specific antigen level, rectal examination findings, age, race, and family history of prostate cancer were significant predictors of finding high-grade cancer on biopsy. The 2 models, based on similar predictors, had comparable discrimination (multiclass area under the curve = 0.63 for the MUSIC model and 0.62 for the PCPT calculator). Calibration analyses demonstrated that the MUSIC model more accurately predicted observed outcomes, whereas the PCPT risk calculator substantively overestimated the likelihood of finding no cancer while underestimating the risk of high-grade cancer in this population. The PCPT risk calculator may not be a good predictor of individual biopsy outcomes for patients seen in contemporary urology practices. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Practical recommendations for performing ultrasound scanning in the urological and andrological fields

    Directory of Open Access Journals (Sweden)

    Pasquale Martino

    2014-03-01

    Full Text Available Aim: US scanning has been defined as the urologist’s stethoscope. These recommendations have been drawn up with the aim of ensuring minimum standards of excellence for ultrasound imaging in urological and andrological practice. A series of essential recommendations are made, to be followed during ultrasound investigations in kidney, prostate, bladder, scrotal and penile diseases. Methods: Members of the Imaging Working Group of the Italian Society of Urology (SIU in collaboration with the Italian Society of Ultrasound in Urology, Andrology and Nephrology (SIEUN identified expert Urologists, Andrologists, Nephrologists and Radiologists. The recommendations are based on review of the literature, previously published recommendations, books and the opinions of the experts. The final document was reviewed by national experts, including members of the Italian Society of Radiology. Results: Recommendations are listed in 5 chapters, focused on: kidney, bladder, prostate and seminal vesicles, scrotum and testis, penis, including penile echo-doppler. In each chapter clear definitions are made of: indications, technological standards of the devices, the method of performance of the investigation. The findings to be reported are described and discussed, and examples of final reports for each organ are included. In the tables, the ultrasound features of the principal male uro-genital diseases are summarized. Diagnostic accuracy and second level investigations are considered. Conclusions: Ultrasound is an integral part of the diagnosis and follow-up of diseases of the urinary system and male genitals in patients of all ages, in both the hospital and outpatient setting. These recommendations are dedicated to enhancing communication and evidence-based medicine in an inter- and multi-disciplinary approach. The ability to perform and interpret ultrasound imaging correctly has become an integral part of clinical practice in uro-andrology, but intra and inter

  10. Path of translational discovery of urological complications of obesity and diabetes.

    Science.gov (United States)

    Daneshgari, Firouz; Liu, Guiming; Hanna-Mitchell, Ann T

    2017-05-01

    Diabetes mellitus (DM) is a prevalent chronic disease. Type 1 DM (T1DM) is a metabolic disorder that is characterized by hyperglycemia in the context of absolute lack of insulin, whereas type 2 DM (T2DM) is due to insulin resistance-related relative insulin deficiency. In comparison with T1DM, T2DM is more complex. The natural history of T2DM in most patients typically involves a course of obesity to impaired glucose tolerance, to insulin resistance, to hyperinsulinemia, to hyperglycemia, and finally to insulin deficiency. Obesity is a risk factor of T2DM. Diabetes causes some serious microvascular and macrovascular complications, such as retinopathy, nephropathy, neuropathy, angiopathy and stroke. Urological complications of obesity and diabetes (UCOD) affect quality of life, but are not well investigated. The urological complications in T1DM and T2DM are different. In addition, obesity itself affects the lower urinary tract. The aim of this perspective is to review the available data, combined with the experience of our research teams, who have spent a good part of last decade on studies of association between DM and lower urinary tract symptoms (LUTS) with the aim of bringing more focus to the future scientific exploration of UCOD. We focus on the most commonly seen urological complications, urinary incontinence, bladder dysfunction, and LUTS, in obesity and diabetes. Knowledge of these associations will lead to a better understanding of the pathophysiology underlying UCOD and hopefully assist urologists in the clinical management of obese or diabetic patients with LUTS. Copyright © 2017 the American Physiological Society.

  11. Clinical characterization of the prostatitis patient in Italy: a prospective urology outpatient study.

    Science.gov (United States)

    Rizzo, Michelangelo; Marchetti, Federico; Travaglini, Fabrizio; Trinchieri, Alberto; Nickel, J Curtis

    2005-02-01

    A prospective multi-center Italian urology outpatient survey, undertaken to determine the prevalence of prostatitis in Italy, provided an ideal opportunity to identify and characterize the typical prostatitis patient presenting to Italian urologists. A total of 70 urologists, representing a cross section of urologic centers in Italy, counted and recorded the overall total male patients reported in the clinic and the overall total patients diagnosed with prostatitis over a 5 week period in late 2001. Data on demographics, previous diagnoses, symptoms (frequency and severity), quality of life, physical examination and laboratory data were prospectively collected. A total of 1,148 patients were identified with prostatitis (12.8%). Of these, 1,074 patients had complete data and could be included in this characterization analysis. The mean age of the prostatitis patients was 47.1 years (range 16-83); two thirds had experienced their first symptom within the last year. A family history of prostatitis was reported by 20.4%. The most common urinary diseases were benign prostatic hyperplasia (17.4%), recurrent urinary tract infection (11.2%) and urinary calculogenesis (11.1%), while the most common concurrent diseases were diabetes (7.2%) and depression (6.8%). The most frequently reported and most severe symptoms at the time of evaluation were irritative voiding symptoms, perineal and suprapubic pain and discomfort. Over three quarters of the patients were dissatisfied with their quality of life. Bacteria were cultured in 15.6%, 17.7% and 14.0% of expressed prostatic secretions, urine specimens after prostatic massage and semen specimens, respectively. Prostatitis is a common outpatient diagnosis, comprising over 10% of male outpatient visits to urologists in Italy. This comprehensive characterization of the typical prostatitis patient diagnosed in routine urological outpatient practice can be employed to generate hypothesis-driven studies in diagnosis and treatment.

  12. Clinical and preclinical treatment of urologic diseases with phosphodiesterase isoenzymes 5 inhibitors: an update

    Directory of Open Access Journals (Sweden)

    Wen-Hao Zhang

    2016-01-01

    Full Text Available Phosphodiesterase isoenzymes 5 inhibitors (PDE5-Is are the first-line therapy for erectile dysfunction (ED. The constant discoveries of nitric oxide (NO/cyclic guanosine monophosphate (cGMP cell-signaling pathway for smooth muscle (SM control in other urogenital tracts (UGTs make PDE5-Is promising pharmacologic agents against other benign urological diseases. This article reviews the literature and contains some previously unpublished data about characterizations and activities of PDE5 and its inhibitors in treating urological disorders. Scientific discoveries have improved our understanding of cell-signaling pathway in NO/cGMP-mediated SM relaxation in UGTs. Moreover, the clinical applications of PDE5-Is have been widely recognized. On-demand PDE5-Is are efficacious for most cases of ED, while daily-dosing and combination with testosterone are recommended for refractory cases. Soluble guanylate cyclase (sGC stimulators also have promising role in the management of severe ED conditions. PDE5-Is are also the first rehabilitation strategy for postoperation or postradiotherapy ED for prostate cancer patients. PDE5-Is, especially combined with α-adrenoceptor antagonists, are very effective for benign prostatic hyperplasia (BPH except on maximum urinary flow rate (Q max with tadalafil recently proved for BPH with/without ED. Furthermore, PDE5-Is are currently under various phases of clinical or preclinical researches with promising potential for other urinary and genital illnesses, such as priapism, premature ejaculation, urinary tract calculi, overactive bladder, Peyronie′s disease, and female sexual dysfunction. Inhibition of PDE5 is expected to be an effective strategy in treating benign urological diseases. However, further clinical studies and basic researches investigating mechanisms of PDE5-Is in disorders of UGTs are required.

  13. SPARING CYSTECTOMY IN THE TREATMENT OF BLADDER CANCER WITH UROLOGICAL COMPLICATIONS

    Directory of Open Access Journals (Sweden)

    A. N. Abizgildin

    2014-08-01

    Full Text Available Bladder cancer (BC accounts for 5 to 10% of all cancers and ranks fourth in the prevalence of male cancers. In Russia, its morbidity increases with age and amounts to 8.1—9.6 per 100,000 with the annual increase being 3.34%.Objective: to assess the results of sparing cystectomy (CE for BC in the presence of urological complications.Subjects and methods. From February 1999 to December 2007, the study consequently included 196 patients receiving surgical treatment for the aggressive form of BC, of whom 101 patients received surgical treatment for CE with intestinal plastic repair. There were 33 (84.6% males and 6 (15.4% females. The patients' mean age was 69.4 (range 35-81 years; the duration of the disease averaged 1.4 years (range 6 months to 5 years. The proportion of the males who has undergone sparing CE was 48.5% of the total number of patients. There were no women who had been operated on.Results. Examination of 101 patients with invasive CE revealed that 69 patients had the following types of complications: intractable bleeding, hydronephrosis, acute pyelonephritis, chronic renal failure, progressive cancer intoxication, and acute urinary retention. These patients were determined as having undergone sparing CE. Group 2 comprised 127 patients who had received organ-preserving therapy.Conclusion. Physical examination, instrumental, and X-ray studies established a correlation of the tumor aggression with the severity of urological complications; sparing CE for urological involvement in patients with invasive UBC has an advantage over organ-preserving treatment (33.3% versus 4.7% in providing 5-year survival. However, the early postoperative mortality from occurring complications was higher in Group 1 than that in Group 2 without radical treatment.

  14. SPARING CYSTECTOMY IN THE TREATMENT OF BLADDER CANCER WITH UROLOGICAL COMPLICATIONS

    Directory of Open Access Journals (Sweden)

    A. N. Abizgildin

    2009-01-01

    Full Text Available Bladder cancer (BC accounts for 5 to 10% of all cancers and ranks fourth in the prevalence of male cancers. In Russia, its morbidity increases with age and amounts to 8.1—9.6 per 100,000 with the annual increase being 3.34%.Objective: to assess the results of sparing cystectomy (CE for BC in the presence of urological complications.Subjects and methods. From February 1999 to December 2007, the study consequently included 196 patients receiving surgical treatment for the aggressive form of BC, of whom 101 patients received surgical treatment for CE with intestinal plastic repair. There were 33 (84.6% males and 6 (15.4% females. The patients' mean age was 69.4 (range 35-81 years; the duration of the disease averaged 1.4 years (range 6 months to 5 years. The proportion of the males who has undergone sparing CE was 48.5% of the total number of patients. There were no women who had been operated on.Results. Examination of 101 patients with invasive CE revealed that 69 patients had the following types of complications: intractable bleeding, hydronephrosis, acute pyelonephritis, chronic renal failure, progressive cancer intoxication, and acute urinary retention. These patients were determined as having undergone sparing CE. Group 2 comprised 127 patients who had received organ-preserving therapy.Conclusion. Physical examination, instrumental, and X-ray studies established a correlation of the tumor aggression with the severity of urological complications; sparing CE for urological involvement in patients with invasive UBC has an advantage over organ-preserving treatment (33.3% versus 4.7% in providing 5-year survival. However, the early postoperative mortality from occurring complications was higher in Group 1 than that in Group 2 without radical treatment.

  15. Magnetic resonance urography and laparoscopy in paediatric urology: a case series.

    Science.gov (United States)

    Damasio, Maria Beatrice; Costanzo, Sara; Podestà, Emilio; Ghiggeri, Gianmarco; Piaggio, Giorgio; Faranda, Fabio; Degl'Innocenti, Maria Ludovica; Jasonni, Vincenzo; Magnano, Gian Michele; Buffa, Piero; Montobbio, Giovanni; Mattioli, Girolamo

    2013-11-01

    Paediatric urology often presents challenging scenarios. Magnetic resonance urography (MRU) and laparoscopy are increasingly used. We retrospectively studied children affected by a disease of the upper urinary tract who after MRU were elected for laparoscopic treatment. This pictorial essay draws on our experience; it illustrates some specific MRU findings and highlights the usefulness of MRU for the diagnosis of upper urinary tract pathology in children. It also offers some examples of the potential additional diagnostic information provided by laparoscopy as well as its therapeutic role.

  16. Bilateral Staghorn Calculus with Forgotten Double J Stent in Ileal Conduit Patient - A Rare Urological Challenge.

    Science.gov (United States)

    Gupta, Rupesh; Dey, Ranjan Kumar; Sharma, Rakesh; Gupta, Sweta

    2017-06-01

    Forgotten DJ stent associated stone formation is not an uncommon entity. Here we are reporting the uncommon case of bilateral staghorn calculus due to forgotten DJ stent who had undergone radical cystectomy with ileal conduit diversion six years back. Management of these cases is a challenging urological situation due to inaccessible ureteric orifices. Patient was successfully treated with minimally invasive therapy in the form of combined bilateral PCNL (Percutaneous Nephrolithotomy) and ESWL (Extracorporeal Shock Wave Lithotripsy) therapy. The purpose of reporting this case is to highlight the grave consequences of a forgotten DJ stent and to discuss the difficulties encountered during the surgical steps of stone removal.

  17. [Johannes Anton von Mikulicz-Radecki (1850-1905). His contributions to the development of urology].

    Science.gov (United States)

    Zajaczkowski, T; Zamann, A M

    2010-02-01

    On June 14, 1905, Johann Anton von Mikulicz-Radecki, one of the most famous surgeons of the time, died. He was a disciple of famous Theodor Billroth of Vienna and the teacher of Ferdinand Sauerbruch in Breslau. Mikulicz-Radecki's merits in the field of the history of medicine are based on his achievements in developing the system of antisepsis and asepsis. He also devoted himself to urological surgery, and his name is linked with diseases, operations, and construction of new medical instruments. Mikulicz-Radecki created two surgical schools, one in Cracow and a second one in Breslau, where he worked for over 15 years until his death.

  18. The use of urologic investigations among patients with traumatic spinal cord injuries

    Directory of Open Access Journals (Sweden)

    Welk B

    2016-02-01

    Full Text Available Blayne Welk,1,2 Kuan Liu,2 Salimah Z Shariff,2 1Department of Surgery and Epidemiology and Biostatistics, Western University, ON, Canada; 2Institute for Clinical Evaluative Sciences – Western (ICES Western, London, ON, CanadaObjective: To assess the use of urologic investigations among traumatic spinal cord injury (TSCI patients.Methods: This is a retrospective cohort study from Ontario, Canada. We included all adult TSCI patients injured between 2002 and 2012. The primary outcome was the frequency of urodynamic testing, renal imaging, and cystoscopy. Primary exposure was the year of injury. The impact of age, sex, comorbidity, socioeconomic status, and lesion level was assessed with Cox regression models.Results: One thousand five hundred and fifty one incident TSCI patients were discharged from a rehabilitation hospital. The median follow-up time of this cohort was 5.0 years (interquartile range =2.9–7.5. At least one urodynamics, renal imaging, or cystoscopy was performed during follow-up for 50%, 80%, and 48% of the cohort, respectively. The overall rate of these tests was 0.22, 0.60, and 0.22 per person-year of follow-up. The proportion of patients who had regular, yearly urodynamics (<2%, renal imaging (6%, or cystoscopy (<2% was low. There were no significant linear trends in the use of these tests over the 10-year study period. Urodynamics were significantly less likely to be performed in patients over 65 years of age (hazard ratio [HR] =0.63, P<0.01 and those with a higher level of comorbidity (HR =0.72, P<0.01. Patients with quadriplegia were significantly less likely to receive any of the investigations compared to those with paraplegia.Conclusion: Renal imaging is done at least once for the majority of patients with TSCI; however, only half undergo urodynamics or cystoscopy. Few patients have regular urologic testing. The reality of urologic testing after TSCI is very different from urologist's ideals and practice guidelines

  19. [The German Museum for the History of Medicine: a museum tour from the perspective of urology].

    Science.gov (United States)

    Ruisinger, M M

    2012-08-01

    In 1973, Germany's first museum of the history of medicine was founded in the former anatomical theatre of Ingolstadt University. Today, the baroque building with its beautiful medical garden is one of the attractions of the old city of Ingolstadt. The paper gives a round tour through the permanent exhibition, the medical technology wing and the herbal garden. The emphasis is put on those objects and plants which have a connection to the history of urology, from a "ladies urinal" to the world's first ESWL apparatus.

  20. Sea level variabilities in the Gulf Stream between Cape Hatteras and 50 deg W - A Geosat study

    Science.gov (United States)

    Vazquez, Jorge; Zlotnicki, Victor; Fu, Lee-Lueng

    1990-01-01

    Sea level variabilities in the Gulf Stream between Cape Hatteras and 50 deg W were examined by studying sea level residuals, relative to a 2-yr mean sea level, obtained from Geosat altimetry data for the period between November 1986 and December 1988. An array of sea-level time series was constructed for a region bounded by 30 deg N and 45 deg N in latitude and by 80 deg W and 50 deg W longitude. It is shown that the spectral characteristics of this time series varies with geographic location along the Gulf Stream path. Concurrent NOAA IR images are used to aid in the interpretation of sea level observations in terms of the variability of the stream's path, demonstrating the synergistic value of the combination of satellite-altimeter and IR data.

  1. Creep crack growth in a reactor pressure vessel steel at 360 deg C

    Energy Technology Data Exchange (ETDEWEB)

    Rui Wu; Seitisleam, F.; Sandstroem, R. [Swedish Institute for Metals Research, Stockholm (Sweden)

    1998-12-31

    Plain creep (PC) and creep crack growth (CCG) tests at 360 deg C and post metallography were carried out on a low alloy reactor pressure vessel steel (ASTM A508 class 2) with different microstructures. Lives for the CCG tests were shorter than those for the PC tests and this is more pronounced for simulated heat affected zone microstructure than for the parent metal at longer lives. For the CCG tests, after initiation, the cracks grew constantly and intergranularly before they accelerated to approach rupture. The creep crack growth rate is well described by C*. The relations between reference stress, failure time and steady crack growth rate are presented for the CCG tests. It is demonstrated that the failure stress due to CCG is considerably lower than the yield stress at 360 deg C. Consequently, the CCG will control the static strength of a reactor vessel. (orig.) 17 refs.

  2. The first winter solstice observed at the meridian line of Santa Maria degli Angeli in Rome

    CERN Document Server

    Sigismondi, Costantino

    2014-01-01

    The page written by the astronomer Francesco Bianchini (1662-1729) and containing the data of the 1701 winter solstice observed at Santa Maria degli Angeli is presented for the first time in figure 2 and widely discussed along this paper. The great meridian line in the Basilica of Santa Maria degli Angeli in Rome was built in 1701/1702 with the scope to measure the Obliquity of the Earth's orbit in the following eight centuries, upon the will of pope Clement XI. During the winter solstice of 1701 the first measurements of the obliquity have been realized by Francesco Bianchini, the astronomer who designed the meridian line, upgrading the similar instrument realized by Giandomenico Cassini in San Petronio, Bononia. In this paper the accuracy of the data observed by Francesco Bianchini is discussed and compared with up-to-date ephemerides. The modern situation of this historical instrument is also presented.

  3. Isothermal section at 1400 deg. C of the Ti-Zr-Sn system

    Energy Technology Data Exchange (ETDEWEB)

    Saltykov, V.A. [I.N. Frantsevich Institute for Problems of Materials Science, Str. Krzhyzhanovsky, 3, Kiev 03142 (Ukraine)], E-mail: ssaltykov@ipms.kiev.ua; Meleshevich, K.A.; Samelyuk, A.V.; Verbytska, O.M.; Bulanova, M.V. [I.N. Frantsevich Institute for Problems of Materials Science, Str. Krzhyzhanovsky, 3, Kiev 03142 (Ukraine)

    2008-07-14

    By the methods of X-ray diffraction, metallography and microprobe examinations the character of phase equilibria at 1400 deg. C is studied for the Ti-(Ti,Zr){sub 5}Sn{sub 3}-Zr region of the Ti-Zr-Sn system. The isothermal section at 1400 deg. C is constructed. This is similar to the solidus surface and is characterized by two 3-phase regions: <{beta}Ti,Zr> + Ti{sub 3}Sn + (Ti,Zr){sub 5}Sn{sub 3} and Ti{sub 3}Sn + Ti{sub 2}Sn + (Ti,Zr){sub 5}Sn{sub 3}. Solubility of Sn in <{beta}Ti,Zr> solid solution is between 10 and 15 at.% Sn. Solubility of zirconium in Ti{sub 3}Sn is about 12 at.%.

  4. Iron oxidation kinetics study by using infrared spectral emissivity measurements below 570deg. C

    Energy Technology Data Exchange (ETDEWEB)

    Campo, Leire del [Departamento de Fisica de la Materia Condensada, Facultad de Ciencia y Tecnologi' a, Universidad del Pai' s Vasco, Barrio Sarriena s/n, 48940 Leioa, Bizkaia (Spain); Perez-Saez, Raul B. [Departamento de Fisica de la Materia Condensada, Facultad de Ciencia y Tecnologi' a, Universidad del Pai' s Vasco, Barrio Sarriena s/n, 48940 Leioa, Bizkaia (Spain); Instituto de Sintesis y Estudio de Materiales, Universidad del Pais Vasco, Apdo. 644, 48080 Bilbao (Spain)], E-mail: raul.perez@ehu.es; Tello, Manuel J. [Departamento de Fisica de la Materia Condensada, Facultad de Ciencia y Tecnologi' a, Universidad del Pai' s Vasco, Barrio Sarriena s/n, 48940 Leioa, Bizkaia (Spain); Instituto de Sintesis y Estudio de Materiales, Universidad del Pais Vasco, Apdo. 644, 48080 Bilbao (Spain)

    2008-01-15

    The oxidation kinetics of iron below 570deg. C is investigated through the dependence of the spectral emissivity on the surface oxidation state. Using the theory of radiative effects of thin films, the oxide scale thickness is obtained as a function of time. A parabolic growth has been observed in all the cases, and applying Wagner's theory, the oxidation parabolic rate constants have been calculated at four temperatures. The temperature dependence of these results has additionally been used to obtain the activation energy of the oxidation process in iron. The parabolic rate constants and activation energy values are in good agreement with the theoretical predictions, and this suggests that the lattice diffusion mechanisms for the high temperature magnetite growth also occur until 400deg. C. The experimental results are also useful to test the applicability of emissivity measurements for in situ oxidation kinetics studies in the spectral range where the scales are optically thin.

  5. Millimeter and sub-millimeter heterodyne mixing based on 2DEG hot-electron bolometers

    Science.gov (United States)

    Wang, Kai; Bell, Matthew; Ramaswamy, Rahul; Sergeev, Andrei; Strasser, Gottfried; Mitin, Vladimir

    2010-03-01

    We investigate GHz and THz heterodyne mixer based on the electron heating effect of a two-dimensional electron gas (2DEG) by electromagnetic radiation at liquid nitrogen temperatures (77K). The devices are fabricated from AlGaAs/GaAs heterostructures with a channel width of 150 μm and lengths varying from 3-20 μm. Steady-state measurements are used to investigate electron heating in these devices and determine basic parameters, such as electron-phonon energy relaxation time and electron heat capacity. We perform mixing experiments at ˜100 GHz frequency range with two Gunn diodes as the radiation sources, and find that electron heating is the primary mixing mechanism at these frequencies. For the mixing experiments at ˜ 2 terahertz range, a quantum cascade laser (QCL) is employed as the local oscillator. To optimize our device, we also investigate electron kinetics and transport properties in the 2DEG hot-electron bolometer.

  6. Current status of natural orifice trans-endoscopic surgery (NOTES and laparoendoscopic single site surgery (LESS in urologic surgery

    Directory of Open Access Journals (Sweden)

    Rafael E. Sanchez-Salas

    2010-08-01

    Full Text Available Laparoendoscopic single site surgery (LESS and natural orifice transluminal endoscopic surgery (NOTES represent novel approaches in urological surgery. To perform a review of the literature in order describe the current status of LESS and NOTES in Urology. References for this manuscript were obtained by performing a review of the available literature in PubMed from 01-01-02 to 15-05-09. Search terms included single port, single site, NOTES, LESS and single incision. A total of 412 manuscripts were initially identified. Out of these, 64 manuscripts were selected based in their urological content. The manuscript features subheadings for experimental and clinical studies, as NOTES-LESS is a new surgical technique and its future evolution will probably rely in initial verified feasibility. A subheading for reviews presents information regarding common language and consensus for the techniques. The issue of complications published in clinical series and the future needs of NOTES-LESS, are also presented.

  7. The impact of the National Treatment Purchase Fund on numbers of core urology training cases at University Hospital Galway.

    LENUS (Irish Health Repository)

    Harney, T J

    2011-06-01

    Since the National Treatment Purchase Fund (NTPF) scheme was introduced in 2002, public patients waiting longer than three months for investigations and treatment are offered care in the private medical sector. Our aim was to assess the impact of the NTPF scheme on the number of training cases performed at University Hospital Galway (UHG). The number and type of urological procedures performed in the private medical sector under the NTFP scheme in 2008 were obtained from the UHG waiting list office. The number of these procedures performed on public patients by trainees at UHG in 2008 was determined retrospectively by reviewing theatre records. A significant number of core urology procedures were performed in the private sector via the NTPF scheme. Cancer centre designation and implementation of the EWTD will also place further pressures on urological training opportunities in Ireland.

  8. PUMA-PUblication MAnagement: sistemi per la gestione delle pubblicazioni degli enti di ricerca

    OpenAIRE

    Biagioni, Stefania

    2005-01-01

    Lo scopo di questa presentazione ? quello di illustrare i) come ? stato realizzato un ciclo gestionale completo dell'informazione: dall'inserimento dei metadati e dei documenti digitali alla restituzione degli stessi all'utente finale; ii) come sono stati resi accessibili via web, a livelli diversi e secondo viste diverse l'informazione prodotta; iii) come siano stati creati servizi differenti utilizzando gli stessi oggetti. Vengono illustrati i sistemi utilizzati presso il CNR di Pisa per la...

  9. Proteomica degli exosomi urinari per la ricerca di biomarcatori nella nefropatia diabetica e nelle tubulopatie ereditarie

    OpenAIRE

    Corbetta,

    2015-01-01

    Le urine costituiscono il fluido biologico di elezione nella ricerca di biomarcatori per le patologie renali in quanto possono essere raccolte in modo semplice e non invasivo; una strategia per la semplificazione del proteoma urinario è rappresentata dall’isolamento degli exosomi urinari (UE), nanovescicole di membrana (30-100 nm) rilasciate dalle cellule epiteliali nello spazio urinario. In questo lavoro abbiamo focalizzato l’attenzione sulla nefropatia diabetica (DN), una comune complicazio...

  10. Observation of Polar Mesosphere Summer Echoes using the Northernmost MST Radar at Eureka (80 deg N)

    Science.gov (United States)

    Swarnalingam, N.; Hocking, W.; Janches, D.; Drummond, J.

    2017-01-01

    We investigate long-term Polar Mesosphere Summer Echoes (PMSEs) observations conducted by the northern most geographically located MST radar at Eureka (80 deg N, 86 deg W). While PMSEs are a well recognized summer phenomenon in the polar regions, previous calibrated studies at Resolute Bay and Eureka using 51.5 MHz and33 MHz radars respectively, showed that PMSE backscatter signal strengths are relatively weak in the polar cap sites, compared to the auroral zone sites (Swarnalingam et al., 2009b; Singer et al., 2010). Complications arise with PMSEs in which the echo strength is controlled by the electrons, which are, in turn, influenced by heavily charged ice particles as well as the variability in the D-region plasma. In recent years, PMSE experiments were conducted inside the polar cap utilizing a 51 MHz radar located at Eureka. In this paper, we investigate calibrated observations, conducted during 2009-2015. Seasonal and diurnal variations of the backscatter signal strengths are discussed and compared to previously published results from the ALOMAR radar, which is a radar of similar design located in the auroral zone at Andenes, Norway (69 deg N, 16 deg E). At Eureka, while PMSEs are present with a daily occurrence rate which is comparable to the rate observed at the auroral zone site for at least two seasons, they show a great level of inter-annual variability. The occurrence rate for the strong echoes tends to be low. Furthermore, comparison of the absolute backscatter signal strengths at these two sites clearly indicates that the PMSE backscatter signal strength at Eureka is weak. Although this difference could be caused by several factors, we investigate the intensity of the neutral air turbulence at Eureka from the measurements of the Doppler spectrum of the PMSE backscatter signals. We found that the level of the turbulence intensity at Eureka is weak relative to previously reported results from three high latitude sites.

  11. Survey of the sky at the 8. 7 and 14. 4 GHz frequencies in the 0 deg - 4 deg declination range

    Energy Technology Data Exchange (ETDEWEB)

    Amirkhanyan, V.R.; Gorshkov, A.G.; Kapustkin, A.A.; Konnikova, V.K.; Lazutkin, A.N.; Larionov, M.G.; Nikanorov, A.S.; Sidorenkov, V.N.; Ugol' kova, L.S.; Khromov, O.I. (Moskovskij Gosudarstvennyj Univ. (USSR). Gosudarstvennyj Astronomicheskij Inst. ' ' GAISh' ' )

    Using the RATAN-600 radiotelescope of the USSR Academy of Sciences (from March 1979 to January 1980) the sky is observed at the 8.7 and 14.4 GHz frequencies in the 0-4 deg declination range. Lists of 82 and 24 radiosources detected at the given frequencies are presented. Six radiosources are detected for the first time. Right ascension and declination, as well as the maximum values of radio-frequency radiation fluxes are given. The problems of measuring accuracies of fluxes and coordinates and the problem of validity of detected radiosources are discussed. On the basis of comparison of the data obtained with those in other works the systematic deviation in fluxes of sources is not more than 7%.

  12. Submillimeter wavelength survey of the galactic plane from l = -5 deg to l = +62 deg - Structure and energetics of the inner disk

    Science.gov (United States)

    Hauser, M. G.; Silverberg, R. F.; Stier, M. T.; Kelsall, T.; Gezari, D. Y.; Dwek, E.; Walser, D.; Mather, J. C.; Cheung, L. H.

    1984-01-01

    Observational results are presented from a new large-scale survey of the first quadrant of the galactic plane at wavelengths of 150, 250, and 300 microns, with a 10 x 10 arcmin beam. The emission detected in the survey arises from compact sources, most of which are identified with known peaks of 5 GHz or CO emission, or both, and from an underlying diffuse background with a typical angular width of about 0.9 deg (FWHM) which accounts for most of the emission. A total of 80 prominent discrete sources are identified and characterized, of which about half have not previously been reported at far-infrared wavelengths. The total infrared luminosity within the solar circle is about 1 to 2 x 10 to the 10th solar luminosity, and is probably emitted by dust that resides in molecular clouds.

  13. Submillimeter wavelength survey of the galactic plane from l = -5 deg to l = +62 deg: Structure and energetics of the inner disk

    Science.gov (United States)

    Hauser, M. G.; Silverberg, R. F.; Stier, M. T.; Kelsall, T.; Gezari, D. Y.; Dwek, E.; Walser, D.; Mather, J. C.; Cheung, L. H.

    1984-01-01

    Results from a large scale survey of the first quadrant of the Milky Way galactic plane at wavelengths of 150, 250, and 300 microns with a 10x10 arcmin beam are presented. The emission detected in the survey arises from compact sources, most of which are identified with known peaks of 5 GHz and/or CO emission, and from an underlying diffuse background with a typical angular width of approximately 0.9 deg (FWHM) which accounts for most of the emission. A total of 80 prominent discrete sources were identified and characterized, of which about half were not previously reported at far infrared wavelengths. The total infrared luminosity within the solar circle is approximately 1 to 2x10 to the 10th power L sub 0, and is probably emitted by dust that resides in molecular clouds.

  14. Vortex lift augmentation by suction on a 60 deg swept Gothic wing

    Science.gov (United States)

    Taylor, A. H.; Jackson, L. R.; Huffman, J. K.

    1982-01-01

    An experimental investigation was conducted in the Langley high-speed 7- by 10-foot wind tunnel to determine the aerodynamic performance of suction applied near the wing tips above the trailing edge of a 60 deg swept Gothic wing. Moveable suction inlets were symmetrically mounted in the proximity of the trailing edge, and the amount of suction was varied to maximize wing lift. Tests were conducted at Mach 0.15, 0.30, and 0.45, and the angle of attack was varied from -4 to 50 deg. The suction augmentation increases the lift coefficient over the entire range of angle of attack. The lift improvement exceeds the unaugmented wing lift by over 20%. Moreover, the augmented lift exceeds the lift predicted by vortex lattice theory to 30 deg angle of attack. Suction augmentation is postulated to strengthen the vortex system by increasing its velocity and making it more concentrated. This causes the vortex breakdown to be delayed to a higher angle of attack

  15. submitter Technical Note: Using DEG-CPCs at upper tropospheric temperatures

    CERN Document Server

    Wimmer, D; Nieminen, T; Duplissy, J; Ehrhart, S; Almeida, J; Rondo, L; Franchin, A; Kreissl, F; Bianchi, F; Manninen, H E; Kulmala, M; Curtius, J; Petäjä, T

    2015-01-01

    Over the last few years, several condensation particle counters (CPCs) capable of measuring in the sub-3 nm size range have been developed. Here we study the performance of CPCs based on diethylene glycol (DEG) at different temperatures during Cosmics Leaving OUtdoor Droplets (CLOUD) measurements at CERN. The data shown here are the first set of verification measurements for sub-3 nm CPCs under upper tropospheric temperatures using atmospherically relevant aerosol particles. To put the results in perspective we calibrated the DEG-CPC at room temperature, resulting in a cut-off diameter of 1.4 nm. All diameters refer to mobility equivalent diameters in this paper. At upper tropospheric temperatures ranging from 246.15 K to 207.15 K, we found cut-off sizes relative to a particle size magnifier in the range of 2.5 to 2.8 nm. Due to low number concentration after size classification, the cut-off diameters have a high uncertainty (±0.3 nm) associated with them. Operating two laminar flow DEG-CPCs with different c...

  16. Sexy DEG/ENaC channels involved in gustatory detection of fruit fly pheromones.

    Science.gov (United States)

    Pikielny, Claudio W

    2012-11-06

    Hydrocarbon pheromones on the cuticle of Drosophila melanogaster modulate the complex courtship behavior of males. Recently, three members of the degenerin/epithelial Na+ channel (DEG/ENaC) family of sodium channel subunits, Ppk25, Ppk23, and Ppk29 (also known as Nope), have been shown to function in gustatory perception of courtship-modulating contact pheromones. All three proteins are required for the activation of male courtship by female pheromones. Specific interactions between two of them have been demonstrated in cultured cells, suggesting that, in a subset of cells where they are coexpressed, these three subunits function within a common heterotrimeric DEG/ENaC channel. Such a DEG/ENaC channel may be gated by pheromones, either directly or indirectly, or alternatively may control the excitability of pheromone-sensing cells. In addition, these studies identify taste neurons that respond specifically to courtship-modulating pheromones and mediate their effects on male behavior. Two types of pheromone-sensing taste neurons, F and M cells, have been defined on the basis of their specific response to either female or male pheromones. These reports set the stage for the dissection of the molecular and cellular mechanisms that mediate gustatory detection of contact pheromones.

  17. EDD, a novel phosphotransferase domain common to mannose transporter EIIA, dihydroxyacetone kinase, and DegV.

    Science.gov (United States)

    Kinch, Lisa N; Cheek, Sara; Grishin, Nick V

    2005-02-01

    Using a recently developed program (SCOPmap) designed to automatically assign new protein structures to existing evolutionary-based classification schemes, we identify a evolutionarily conserved domain (EDD) common to three different folds: mannose transporter EIIA domain (EIIA-man), dihydroxyacetone kinase (Dak), and DegV. Several lines of evidence support unification of these three folds into a single superfamily: statistically significant sequence similarity detected by PSI-BLAST; "closed structural grouping" using DALI Z-scores (each protein inside a group finds all other group members with scores higher than those to proteins outside the group) that includes only these proteins sharing a unique alpha-helical hairpin at the C-terminus and excludes all other proteins with similar topology; similar domain fusions connect Dak and DegV, and genomic neighborhood organizations connect Dak and EIIA-man. Finally, both Dak and EIIA-man perform similar phosphotransfer reactions, suggesting a phosphotransferase activity for the DegV-like family of proteins, whose function other than lipid binding revealed in the crystal structure remains unknown.

  18. Elevated prostate specific antigen and reduced 10-year survival among a cohort of Danish men consecutively referred from primary care to an urological department during 2005-2006

    DEFF Research Database (Denmark)

    Hillig, Thore; Nielsen, Torben Kjær; Hansen, Steen Ingemann;

    2017-01-01

    referred from GP to an Urological Specialist and to investigate prognostic factors and survival in the cohort. A total of 1261 consecutive male patients without previously known prostate cancer (PCa) were referred to the same Department of Urology during June 2005 to August 2006. Some 299 patients were...

  19. Serious renal and urological complications in fast-track primary total hip and knee arthroplasty; a detailed observational cohort study

    DEFF Research Database (Denmark)

    Bjerregaard, Lars S; Jorgensen, Christoffer C; Kehlet, Henrik

    2016-01-01

    BACKGROUND: Overall medical complications have been reduced after fast-track total hip (THA) and knee arthroplasty (TKA), but data on specific renal and urological (RU) complications are limited. METHODS: To describe the incidence and consequences of serious RU complications resulting in length...... postoperatively. Seven complications . (0.08 %) were urological, mainly haematuria after bladder catheterisation, whereas 5 (0.06 were urosepsis/pyelonephritis. CONCLUSION: The overall incidence of serious RU complications after fast-track THA and TKA was 0.61 %. AKI occurred in 0.49% and was most often due...

  20. A place of androgen deficiency in a clinical portrait of the modern urological patient

    Directory of Open Access Journals (Sweden)

    I. A. Tyuzikov

    2013-01-01

    Full Text Available In article on the basis of literary given both own clinical supervision and researches applied aspects of androgen deficiency in urological practice are considered. True androgen deficiency’ frequency in man’s population remains precisely not established as decrease in testosterone synthesis is connected not only with the age, but also varieties of other factors, including features of geography of area of residing, presence or absence of other hormonal and metabolic disorders, accompanying somatic comorbidity etc. Results of the newest foreign epidemiological researches of androgen deficiency prevalence worldwide, and also results of the first Russian pilot epidemiological research of androgen deficiency at men prevalence in practice of urologists and doctors of adjacent specialities (Yaroslavl Study, 2013 present in the article. Intime pathogenetic communication of androgen deficiency both the most widespread uroandrological and somatic diseases at men is shown. On the basis of own clinical experience optimum algorithms of complex diagnostics of androgen deficiency at urological patients are offered and also the necessity of inclusion of testosterone preparations for pharmacotherapy of the majority of male urinogenital diseases is shown. The review of indications, contra-indications, estimations of risk factors and preparations for androgen replacement therapy is spent. Features of transdermal forms of testosterone preparations (Аndrogel are described and the clinical analysis of their present and perspective application within the limits of modern androgen replacement therapy is carried out.