WorldWideScience

Sample records for deficit reduction act

  1. Marine Debris Research, Prevention, and Reduction Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Marine Debris Research, Prevention, and Reduction Act legally establishes the National Oceanic and Atmospheric Administration's (NOAA) Marine Debris Program. The...

  2. Deficit

    CERN Multimedia

    2002-01-01

    UCL's former provost, Sir Derek Roberts, has been drafted in for a year to run the college. UCL is expected to have a 6 million pounds deficit this year and up to a 10 million pounds deficit next year. Sir Christopher Llewellyn-Smith took over at UCL nearly 4 years ago and decided then that the finanical situation was serious enough to warrant a reduction in the vast expansion policy undertaken by his predecessor (1 page).

  3. 48 CFR 3427.471 - Paperwork Reduction Act clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Paperwork Reduction Act... Copyrights 3427.471 Paperwork Reduction Act clause. The contracting officer shall insert the clause in 3452.227-71, Paperwork Reduction Act, in all solicitations and contracts....

  4. 31 CFR 547.901 - Paperwork Reduction Act notice.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Paperwork Reduction Act notice. 547.901 Section 547.901 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... REGULATIONS Paperwork Reduction Act § 547.901 Paperwork Reduction Act notice. For approval by the Office of...

  5. 78 FR 71615 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-11-29

    ... Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information... Paperwork Reduction Act (44 U.S.C. Chapter 35). To request a copy of these requests, call (404) 639-7570...

  6. 78 FR 64502 - Agency Forms Undergoing Paperwork Reduction Act

    Science.gov (United States)

    2013-10-29

    ... Act The Centers for Disease Control and Prevention (CDC) publishes a list of information collection... Reduction Act (44 U.S.C. Chapter 35). To request a copy of these requests, call (404) 639-7570 or send...

  7. 7 CFR 12.34 - Paperwork Reduction Act assigned number.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Paperwork Reduction Act assigned number. 12.34 Section 12.34 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION Wetland Conservation § 12.34 Paperwork Reduction Act assigned number. The information...

  8. 78 FR 69855 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-11-21

    ... Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information... Paperwork Reduction Act (44 U.S.C. Chapter 35). To request a copy of these requests, call (404) 639-7570 or... Health Service Act (41 U.S.C. 241) Section 301. The revision request does not affect the...

  9. 75 FR 9902 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-03-04

    ... reports include: Creutzfeldt-Jakob Disease (CJD), Cyclospora, Dengue, Hantavirus, Kawasaki Syndrome... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of...

  10. 78 FR 15368 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-03-11

    ... (CJD), Cyclosporiasis, Dengue, Hantavirus, Kawasaki Syndrome, Legionellosis, Lyme disease, Malaria... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of...

  11. 76 FR 40915 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-07-12

    ... and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of...

  12. 75 FR 63485 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-10-15

    ... the National Electronic Telecommunications System for Surveillance (NETSS) to reflect its national... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information...

  13. 76 FR 34705 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-06-14

    ... or foot injury; having a family member who has had a DVT; taking birth control pills; or getting... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information...

  14. 77 FR 61406 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-10-09

    ...-- National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of...

  15. 75 FR 154 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-01-04

    ... for Zoonotic, Vector-Borne, and Enteric Diseases (NCZVED), Centers for Disease Control and Prevention... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of...

  16. 78 FR 59700 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-09-27

    ... Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC). Background and... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of...

  17. 78 FR 13345 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-02-27

    ...)--Revision--National Center Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of...

  18. 76 FR 29243 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-05-20

    ... Reporting Forms--New--National Center for Emerging, Zoonotic and Infectious Diseases (NCEZID), Centers for... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of...

  19. 78 FR 13344 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-02-27

    ... Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC). Background and... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of...

  20. 31 CFR 539.901 - Paperwork Reduction Act notice.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Paperwork Reduction Act notice. 539.901 Section 539.901 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION TRADE...

  1. Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice.

    Directory of Open Access Journals (Sweden)

    Jason S Cheng

    Full Text Available OBJECTIVE: Because reduction of the microtubule-associated protein Tau has beneficial effects in mouse models of Alzheimer's disease and epilepsy, we wanted to determine whether this strategy can also improve the outcome of mild traumatic brain injury (TBI. METHODS: We adapted a mild frontal impact model of TBI for wildtype C57Bl/6J mice and characterized the behavioral deficits it causes in these animals. The Barnes maze, Y maze, contextual and cued fear conditioning, elevated plus maze, open field, balance beam, and forced swim test were used to assess different behavioral functions. Magnetic resonance imaging (MRI, 7 Tesla and histological analysis of brain sections were used to look for neuropathological alterations. We also compared the functional effects of this TBI model and of controlled cortical impact in mice with two, one or no Tau alleles. RESULTS: Repeated (2-hit, but not single (1-hit, mild frontal impact impaired spatial learning and memory in wildtype mice as determined by testing of mice in the Barnes maze one month after the injury. Locomotor activity, anxiety, depression and fear related behaviors did not differ between injured and sham-injured mice. MRI imaging did not reveal focal injury or mass lesions shortly after the injury. Complete ablation or partial reduction of tau prevented deficits in spatial learning and memory after repeated mild frontal impact. Complete tau ablation also showed a trend towards protection after a single controlled cortical impact. Complete or partial reduction of tau also reduced the level of axonopathy in the corpus callosum after repeated mild frontal impact. INTERPRETATION: Tau promotes or enables the development of learning and memory deficits and of axonopathy after mild TBI, and tau reduction counteracts these adverse effects.

  2. 78 FR 20920 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-04-08

    ... its public health activities in a more timely and efficient manner. The benefits to using the EI Generic Clearance include submission of a standardized OMB review package for each EI Generic Information..., Compensation, and Liability Act of 1980 (CERCLA), commonly known as the ``Superfund'' Act, as amended by the...

  3. 77 FR 27065 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-05-08

    ... average of 14 years earlier than nonsmokers. Moreover, cigarette smoking costs more than $193 billion; $97... Smoking Prevention and Tobacco Control Act (Tobacco Control Act) in 2009, the FDA is legally mandated to... potential adverse consequences of FDA's regulatory actions, as the regulatory framework is being...

  4. Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits.

    Science.gov (United States)

    Uutela, M; Lindholm, J; Louhivuori, V; Wei, H; Louhivuori, L M; Pertovaara, A; Akerman, K; Castrén, E; Castrén, M L

    2012-07-01

    Fragile X syndrome (FXS) is a common cause of inherited intellectual disability and a well-characterized form of autism spectrum disorder. As brain-derived neurotrophic factor (BDNF) is implicated in the pathophysiology of FXS we examined the effects of reduced BDNF expression on the behavioral phenotype of an animal model of FXS, Fmr1 knockout (KO) mice, crossed with mice carrying a deletion of one copy of the Bdnf gene (Bdnf(+/-)). Fmr1 KO mice showed age-dependent alterations in hippocampal BDNF expression that declined after the age of 4 months compared to wild-type controls. Mild deficits in water maze learning in Bdnf(+/-) and Fmr1 KO mice were exaggerated and contextual fear learning significantly impaired in double transgenics. Reduced BDNF expression did not alter basal nociceptive responses or central hypersensitivity in Fmr1 KO mice. Paradoxically, the locomotor hyperactivity and deficits in sensorimotor learning and startle responses characteristic of Fmr1 KO mice were ameliorated by reducing BNDF, suggesting changes in simultaneously and in parallel working hippocampus-dependent and striatum-dependent systems. Furthermore, the obesity normally seen in Bdnf(+/-) mice was eliminated by the absence of fragile X mental retardation protein 1 (FMRP). Reduced BDNF decreased the survival of newborn cells in the ventral part of the hippocampus both in the presence and absence of FMRP. Since a short neurite phenotype characteristic of newborn cells lacking FMRP was not found in cells derived from double mutant mice, changes in neuronal maturation likely contributed to the behavioral phenotype. Our results show that the absence of FMRP modifies the diverse effects of BDNF on the FXS phenotype. © 2012 The Authors. Genes, Brain and Behavior © 2012 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

  5. 78 FR 25741 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-05-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction...): National Surveys of Assistance Dog Providers and Veterans, National Institute for Occupational Safety...

  6. 75 FR 65355 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-10-22

    ...--National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Centers for Disease Control... funded by the Affordable Care Act. The case study sites will be selected to include a mix of State or... member of the site management team; four additional CPPW staff members; a mix of seven Community...

  7. 76 FR 45256 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-07-28

    ... Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information... the most costly health problems facing our nation today, and among the most preventable. Risk factors... diabetics have high blood pressure, high cholesterol, or both conditions, the optimal systems to...

  8. 76 FR 75885 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-12-05

    ...- enrollment processes, and the number of inmates with mental illness linked to housing prior to release. NSPHC... Services (DHHS), acting through NCHS, shall collect statistics on the extent and nature of illness and disability of the population of the United States. This one-year clearance request includes data collection...

  9. 76 FR 70729 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-11-15

    ... post-implementation survey of parents of children ages 0-60 months in the target areas for each of the... of the ``Learn the Signs. Act Early.'' Campaign in 4 Target Sites,--New--National Center on Birth...). Background and Brief Description CDC's most recent data show that an average of one in 110 children has...

  10. 76 FR 64351 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-10-18

    ... health care facilities, nurses will also be recruited. These nurses will be recruited from a mailing list... healthcare facility compliance with the New Jersey Violence Prevention in Health Care Facilities Act, and (2... purpose of the interviews is to measure compliance to the state regulations (violence prevention policies...

  11. 78 FR 67148 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-11-08

    ... Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information collection requests under review by the Office of Management and Budget (OMB) in compliance with the... fire or police department (whether fire or emergency personnel, active or retired), worked for...

  12. 77 FR 40359 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-07-09

    ... Quitline Data Warehouse to evaluate the impact of Affordable Care Act, Prevention and Public Health Funds... should be received within 30 days of this notice. Proposed Project National Quitline Data Warehouse (OMB... National Quitline Data Warehouse (NDQW) to collect information from the 50 states, the District of...

  13. 76 FR 38654 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-07-01

    ... multidisciplinary case review team (CRT) will conduct a case review session. Recommendations of the CRT will then be... Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information collection requests under review by the Office of Management and Budget (OMB) in compliance with...

  14. 78 FR 14554 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-03-06

    ... Development of CDC's Act Against AIDS Social Marketing Campaigns Targeting Consumers--New--National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and... marketing campaigns aimed at increasing HIV testing rates, increasing HIV awareness and...

  15. 77 FR 49797 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-08-17

    ... Development of CDC's Act Against AIDS Social Marketing Campaigns Targeting Consumers--New--National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and... marketing campaigns aimed at increasing HIV testing rates, increasing HIV awareness and...

  16. 77 FR 76492 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-12-28

    .... Since the passage of the Early Hearing Detection and Intervention (EHDI) Act, 97% of newborn infants are now screened for hearing loss prior to hospital discharge. However, many of these infants have not received needed hearing test and follow up services after their hospital discharges. The 2009 national...

  17. 78 FR 17406 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-03-21

    ..., by conducting a training program for State and local vital statistics staff to assist in developing... a high degree of uniformity and quality in the data provided by the States. This training program is... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction...

  18. 77 FR 61410 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-10-09

    ... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork Reduction... questions about the usefulness of resources posted on the YSI Web site and satisfaction with the site. No..., CDC's evaluation contractor will use information obtained through Google Analytics to assess...

  19. 75 FR 8724 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-02-25

    ... Relationships Project, and 4th R--have demonstrated reductions in dating violence behaviors in rigorous... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND... Respect Support Groups (ERSG): Preventing and Interrupting Teen Dating Violence among At-Risk Middle...

  20. 78 FR 42079 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-07-15

    ... Relationships Project, and 4th R--have demonstrated reductions in dating violence behaviors in rigorous... violence, and (2) reflect the behaviors of interest and theory of change of Expect Respect. The Reactive Proactive Questionnaire (Raine et al., 2006) has also been included in the instrument packet and will...

  1. 77 FR 29350 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-05-17

    ... change, and well-being which facilitates the reduction of risky sexual behaviors. A convenience sample of... this project is to test the efficacy of an HIV transmission prevention intervention for reducing sexual... and healthcare, sexual activity, substance use, and other psychosocial issues. The duration of...

  2. Effects of Static Magnetic Fields on the Visual Cortex: reversible Visual Deficits and Reduction of Neuronal Activity.

    Science.gov (United States)

    Aguila, Jordi; Cudeiro, Javier; Rivadulla, Casto

    2016-02-01

    Noninvasive brain stimulation techniques have been successfully used to modulate brain activity, have become a highly useful tool in basic and clinical research and, recently, have attracted increased attention due to their putative use as a method for neuro-enhancement. In this scenario, transcranial static magnetic stimulation (SMS) of moderate strength might represent an affordable, simple, and complementary method to other procedures, such as Transcranial Magnetic Stimulation or direct current stimulation, but its mechanisms and effects are not thoroughly understood. In this study, we show that static magnetic fields applied to visual cortex of awake primates cause reversible deficits in a visual detection task. Complementary experiments in anesthetized cats show that the visual deficits are a consequence of a strong reduction in neural activity. These results demonstrate that SMS is able to effectively modulate neuronal activity and could be considered to be a tool to be used for different purposes ranging from experimental studies to clinical applications.

  3. Comparative Evaluation of the Implementation of the Deficit Reduction Act within the Department of Defense.

    Science.gov (United States)

    1986-06-01

    auto:a;ic wicnfl:raW3.s from accounz;. at financial institucions , ana a under wnicn financiaLa. institutions receive ano del-oziL. on beiaif of cne...procedures are implemented to coilect the debt. ’s. Contractor Deot Tne Deot Coi.Lection Status Report is u.;ea Lo manuall -y assess to-,e debts owed by

  4. Financial effect of instituting Deficit Reduction Act documentation requirements in family planning clinics in Oregon.

    Science.gov (United States)

    Rodriguez, Maria Isabel; Angus, Lisa; Elman, Emily; Darney, Philip D; Caughey, Aaron B

    2011-06-01

    The study was conducted to estimate the long-term costs for implementing citizenship documentation requirements in a Medicaid expansion program for family planning services in Oregon. A decision-analytic model was developed using two perspectives: the state and society. Our primary outcome was future reproductive health care costs due to pregnancy in the next 5 years. A Markov structure was utilized to capture multiple future pregnancies. Model inputs were retrieved from the existing literature and local hospital and Medicaid data related to reimbursements. One-way and multi-way sensitivity analyses were conducted. A Monte Carlo simulation was performed to simultaneously incorporate uncertainty from all of the model inputs. Screening for citizenship results in a loss of $3119 over 5 years ($39,382 vs. $42,501) for the state and $4209 for society ($63,391 compared to $59,182) for adult women. Among adolescents, requiring proof of identity and citizenship results in a loss of $3123 for the state ($39,378 versus $42,501) and $4214 for society ($63,391 instead of $59,177). Screening for citizenship status in publicly funded family planning clinics leads to financial losses for the state and society. Copyright © 2011 Elsevier Inc. All rights reserved.

  5. Levetiracetam might act as an efficacious drug to attenuate cognitive deficits of Alzheimer's disease.

    Science.gov (United States)

    Xiao, Rong

    2016-01-01

    Levetiracetam is a homologue of piracetam with an a-ethyl side-chain substitution and it is a Food and Drug Administration (FDA) approved antiepileptic drug. Recently, several studies have found that levetiracetam was able to reduce seizure frequency in epileptic seizures patients without affecting their cognitive functions. In the present review, the effects of levetiracetam on cognitive improvement were summarized in epileptic seizures patients with or without Alzheimer's disease (AD), high-grade glioma (HGG) patients and amnestic mild cognitive impairment (aMCI) patients. In addition, levetiracetam was observed to improve the cognitive deficits in normal aged animals and the transgenic animal models with AD, suggesting that levetiracetam may be a better choice for the prevention or treatment of AD.

  6. 77 FR 12297 - Petition To Demonstrate Paperwork Reduction Act Compliance of the Endocrine Disruptor Screening...

    Science.gov (United States)

    2012-02-29

    ... Subjects Environmental protection, EDSP, Endocrine Disruptors Screening Program, FFDCA orders, List 1... AGENCY Petition To Demonstrate Paperwork Reduction Act Compliance of the Endocrine Disruptor Screening... Request (ICR) of the first list of 67 chemicals to receive orders under the Endocrine Disruptor...

  7. 15 CFR 806.18 - OMB control numbers assigned to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false OMB control numbers assigned to the Paperwork Reduction Act. 806.18 Section 806.18 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF ECONOMIC ANALYSIS, DEPARTMENT OF COMMERCE DIRECT...

  8. 78 FR 40766 - Renewals of Information Collections Under the Paperwork Reduction Act

    Science.gov (United States)

    2013-07-08

    ... Management and Budget (OMB) Control Number 3141-0001; (ii) approval of tribal ordinances, and background... National Indian Gaming Commission Renewals of Information Collections Under the Paperwork Reduction Act... Commission) is seeking comments on the renewal of information collections for the following activities: (i...

  9. 75 FR 33570 - Magnuson-Stevens Act Provisions; Fishing Capacity Reduction Framework

    Science.gov (United States)

    2010-06-14

    ... with the permit or vessel participating in a reduction program and that (if not scrapped) the vessel will be effectively prevented from fishing in Federal or state waters, or fishing on the high seas or in the waters of a foreign nation. The Magnuson-Stevens Reauthorization Act revised section...

  10. [Attention deficit and understanding of non-literal meanings: the interpretation of indirect speech acts and idioms].

    Science.gov (United States)

    Crespo, N; Manghi, D; García, G; Cáceres, P

    To report on the oral comprehension of the non-literal meanings of indirect speech acts and idioms in everyday speech by children with attention deficit hyperactivity disorder (ADHD). The subjects in this study consisted of a sample of 29 Chilean schoolchildren aged between 6 and 13 with ADHD and a control group of children without ADHD sharing similar socio-demographic characteristics. A quantitative method was utilised: comprehension was measured individually by means of an interactive instrument. The children listened to a dialogue taken from a cartoon series that included indirect speech acts and idioms and they had to choose one of the three options they were given: literal, non-literal or distracter. The children without ADHD identified the non-literal meaning more often, especially in idioms. Likewise, it should be pointed out that whereas the children without ADHD increased their scores as their ages went up, those with ADHD remained at the same point. ADHD not only interferes in the inferential comprehension of non-literal meanings but also inhibits the development of this skill in subjects affected by it.

  11. 14 CFR 11.201 - Office of Management and Budget (OMB) control numbers assigned under the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ... PROCEDURES Paperwork Reduction Act Control Numbers § 11.201 Office of Management and Budget (OMB) control... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Office of Management and Budget (OMB) control numbers assigned under the Paperwork Reduction Act. 11.201 Section 11.201 Aeronautics and...

  12. 77 FR 44562 - Public Meeting: Potential Regulatory Implications of the Reduction of Lead in Drinking Water Act...

    Science.gov (United States)

    2012-07-30

    ... Lead in Drinking Water Act of 2011 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... discuss and solicit input from States, manufacturers, drinking water systems, other interested groups and consumers on the implementation of the Reduction of Lead in Drinking Water Act of 2011 (``the Act'')....

  13. Developmentally Stable Whole-Brain Volume Reductions and Developmentally Sensitive Caudate and Putamen Volume Alterations in Those With Attention-Deficit/Hyperactivity Disorder and Their Unaffected Siblings

    NARCIS (Netherlands)

    Greven, Corina U.; Bralten, Janita; Mennes, Maarten; O'Dwyer, Laurence; van Hulzen, Kimm J. E.; Rommelse, Nanda; Schweren, Lizanne J. S.; Hoekstra, Pieter J.; Hartman, Catharina A.; Heslenfeld, Dirk; Oosterlaan, Jaap; Faraone, Stephen V.; Franke, Barbara; Zwiers, Marcel P.; Arias-Vasquez, Alejandro; Buitelaar, Jan K.

    2015-01-01

    IMPORTANCE Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder. It has been linked to reductions in total brain volume and subcortical abnormalities. However, owing to heterogeneity within and between studies and limited sample sizes, findings on the neuroanato

  14. Increasing valued behaviors precedes reduction in suffering: Findings from a randomized controlled trial using ACT.

    Science.gov (United States)

    Gloster, Andrew T; Klotsche, Jens; Ciarrochi, Joseph; Eifert, Georg; Sonntag, Rainer; Wittchen, Hans-Ulrich; Hoyer, Jürgen

    2017-04-01

    Psychological flexibility theory (PFT) suggests three key processes of change: increases in value-directed behaviors, reduction in struggle with symptoms, and reduction in suffering. We hypothesized that Acceptance and Commitment Therapy (ACT) would change these processes and that increases in valued action and decreases in struggle would precede change in suffering. Data were derived from a randomized clinical trial testing ACT (vs. waitlist) for treatment-resistant patients with primary panic disorder with/without agoraphobia (n = 41). Valued behavior, struggle, and suffering were assessed at each of eight sessions. Valued actions, struggle, and suffering all changed over the course of therapy. Overall changes in struggle and suffering were interdependent whereas changes in valued behavior were largely independent. Levels of valued behaviors influenced subsequent suffering, but the other two variables did not influence subsequent levels of valued action. This finding supports a central tenet of PFT that increased (re-)engagement in valued behaviors precedes reductions in suffering. Possible implications for a better understanding of response and non-response to psychotherapy are discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. A Comparison of Effectiveness of Parent Behavioral Management Training and Methylphenidate on Reduction of Symptomsof Attention Deficit Hyperactivity Disorder

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Mohammadi

    2016-09-01

    Full Text Available Attention deficit hyperactivity disorder (ADHD is one of the most common psychological disorders of childhood. Methylphenidate is highly effective in the treatment of ADHD. This study aimed to determine the effectiveness of combined Parent behavioral management training (PBMT and medication treatment (Methylphenidate in reducing ADHD symptoms in 6-12-year-old children, using randomized sampling. A total of 50 children with ADHD were assigned into two groups: an experimental group of PBMT and a control group of medication treatment (Methylphenidate without other interventions. Conners’ Parent Rating Scale (CPRS-48 was employed before and after interventions to determine the effects. Descriptive Statistics method (consisting of Mean and Standard deviation and Statistical inference method, (including t-test and Levene's Test were used for data analysis.  Findings revealed that the combined behavioral intervention of PBMT and methylphenidate treatment is more effective in reduction of ADHD in children. The difference of means between pre-test and post-test of CPRS in the experimental group was equal to 10.77, and it was equal to 1.88 in the control group. In addition, PBMT was more effective in the case of younger parents (P<0.025. However, parents’ education level did not affect the behavioral intervention (P<0.025.The findings suggest that combined intervention of PBMT and methylphenidate is effective in reducing the symptoms of ADHD in children.

  16. A Comparison of Effectiveness of Parent Behavioral Management Training and Methylphenidate on Reduction of Symptomsof Attention Deficit Hyperactivity Disorder.

    Science.gov (United States)

    Mohammadi, Mohammad Reza; Soleimani, Ali Akbar; Ahmadi, Nastaran; Davoodi, Elham

    2016-08-01

    Attention deficit hyperactivity disorder (ADHD) is one of the most common psychological disorders of childhood. Methylphenidate is highly effective in the treatment of ADHD. This study aimed to determine the effectiveness of combined Parent behavioral management training (PBMT) and medication treatment (Methylphenidate) in reducing ADHD symptoms in 6-12-year-old children, using randomized sampling. A total of 50 children with ADHD were assigned into two groups: an experimental group of PBMT and a control group of medication treatment (Methylphenidate) without other interventions. Conners' Parent Rating Scale (CPRS-48) was employed before and after interventions to determine the effects. Descriptive Statistics method (consisting of Mean and Standard deviation) and Statistical inference method, (including t-test and Levene's Test) were used for data analysis.  Findings revealed that the combined behavioral intervention of PBMT and methylphenidate treatment is more effective in reduction of ADHD in children. The difference of means between pre-test and post-test of CPRS in the experimental group was equal to 10.77, and it was equal to 1.88 in the control group. In addition, PBMT was more effective in the case of younger parents (Pmethylphenidate is effective in reducing the symptoms of ADHD in children.

  17. 5 CFR Appendix C to Part 2634 - Privacy Act and Paperwork Reduction Act Notices for Appendixes A and B

    Science.gov (United States)

    2010-01-01

    ... Appendixes A and B Privacy Act Statement Section 102(f) of the Ethics in Government Act of 1978 as amended (the “Ethics Act”) (5 U.S.C. App.) and subpart D of 5 CFR part 2634 of the regulations of the Office of... under the Ethics Act. The primary use of the information on this certificate is for review by...

  18. Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit/hyperactivity disorder treated with methylphenidate.

    Science.gov (United States)

    Bruxel, E M; Salatino-Oliveira, A; Genro, J P; Zeni, C P; Polanczyk, G V; Chazan, R; Rohde, L A; Hutz, M H

    2013-10-01

    Carboxylesterase 1 is the enzyme involved in methylphenidate (MPH) metabolism. The aim of this study was to evaluate the association between a -75 T>G polymorphism and appetite reduction in children with attention-deficit/hyperactivity disorder (ADHD). A sample of 213 children with ADHD was investigated. The primary outcome was appetite reduction measured by the Barkley Stimulant Side Effect Rating Scale applied at baseline, at 1 and 3 months of treatment. MPH doses were augmented until no further clinical improvement or significant adverse events occurred. The G allele presented a trend for association with appetite reduction scores (P=0.05). A significant interaction between the G allele and treatment over time for appetite reduction scores was also observed (P=0.03). The G allele carriers presented a higher risk for appetite reduction worsening when compared with T allele homozygotes (odds ratio=3.47, P=0.01). The present results suggest an influence of carboxylesterase 1 -75 T>G polymorphism on the worsening of appetite reduction with MPH treatment in youths with ADHD.

  19. 7 CFR 62.400 - OMB control number assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ...) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) LIVESTOCK, MEAT, AND OTHER AGRICULTURAL COMMODITIES (QUALITY SYSTEMS...

  20. 77 FR 61008 - Request for Comments Under the Paperwork Reduction Act, Section 3506

    Science.gov (United States)

    2012-10-05

    ... Carr, Acting Director, Office of Clinical Research and Bioethics Policy, Office of Science Policy, NIH... 28, 2012. Sarah Carr, Acting Director, Office of Clinical Research and Bioethics Policy, Office...

  1. Long-acting methylphenidate formulations in the treatment of attention-deficit/hyperactivity disorder: a systematic review of head-to-head studies

    Science.gov (United States)

    2013-01-01

    Background The stimulant methylphenidate (MPH) has been a mainstay of treatment for attention-deficit/hyperactivity disorder (ADHD) for many years. Owing to the short half-life and the issues associated with multiple daily dosing of immediate-release MPH formulations, a new generation of long-acting MPH formulations has emerged. Direct head-to-head studies of these long-acting MPH formulations are important to facilitate an evaluation of their comparative pharmacokinetics and efficacy; however, to date, relatively few head-to-head studies have been performed. The objective of this systematic review was to compare the evidence available from head-to-head studies of long-acting MPH formulations and provide information that can guide treatment selection. Methods A systematic literature search was conducted in MEDLINE and PsycINFO in March 2012 using the MeSH terms: attention deficit disorder with hyperactivity/drug therapy; methylphenidate/therapeutic use and All Fields: Concerta; Ritalin LA; OROS and ADHD; Medikinet; Equasym XL and ADHD; long-acting methylphenidate; Diffucaps and ADHD; SODAS and methylphenidate. No filters were applied and no language, publication date or publication status limitations were imposed. Articles were selected if the title indicated a comparison of two or more long-acting MPH preparations in human subjects of any age; non-systematic review articles and unpublished data were not included. Results Of 15,295 references returned in the literature search and screened by title, 34 articles were identified for inclusion: nine articles from pharmacokinetic studies (nine studies); nine articles from laboratory school studies (six studies); two articles from randomized controlled trials (two studies); three articles from switching studies (two studies) and three articles from one observational study. Conclusions Emerging head-to-head studies provide important data on the comparative efficacy of the formulations available. At a group level, efficacy

  2. 78 FR 44188 - Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment...

    Science.gov (United States)

    2013-07-23

    ... Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment Request... Tennessee Valley Authority is soliciting public comments on this proposed collection as provided by 5 CFR.... Frequency of Use: On Occasion. Type of Affected Public: Individuals. Small Businesses or...

  3. 78 FR 26682 - Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment...

    Science.gov (United States)

    2013-05-07

    ... Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment Request... Tennessee Valley Authority is soliciting public comments on this proposed collection as provided by 5 CFR... Occasion. Type of Affected Public: Individuals. Small Businesses or Organizations Affected: No....

  4. 75 FR 34534 - Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment...

    Science.gov (United States)

    2010-06-17

    ... Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment Request...). The Tennessee Valley Authority is soliciting public comments on this proposed collection as provided... Collection: Section 26a Permit Application. Frequency of Use: On occasion. Type of Affected...

  5. 75 FR 27863 - Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment...

    Science.gov (United States)

    2010-05-18

    ...: 2010-11798] TENNESSEE VALLEY AUTHORITY Paperwork Reduction Act of 1995, as Amended by Public Law 104-13... U.S.C. Chapter 35, as amended). The Tennessee Valley Authority is soliciting public comments on this... Collection: Employment Application. Frequency of Use: On Occasion. Type of Affected Public:...

  6. 75 FR 45697 - Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment...

    Science.gov (United States)

    2010-08-03

    ... Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment Request... Tennessee Valley Authority is soliciting public comments on this proposed collection as provided by 5 CFR... Application. Frequency of Use: On Occasion. Type of Affected Public: Individuals. Small Businesses...

  7. 78 FR 17995 - Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment...

    Science.gov (United States)

    2013-03-25

    ... Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment Request... Tennessee Valley Authority is soliciting public comments on this proposed collection as provided by 5 CFR... Use: On occasion. Type of Affected Public: Individuals or households, state or local...

  8. 75 FR 15492 - Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment...

    Science.gov (United States)

    2010-03-29

    ... Paperwork Reduction Act of 1995, as Amended by Public Law 104-13; Proposed Collection, Comment Request... Tennessee Valley Authority is soliciting public comments on this proposed collection as provided by 5 CFR.... Frequency of Use: On occasion. Type of Affected Public: Individuals or households, state or...

  9. 15 CFR 30.63 - Office of Management and Budget control numbers assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Office of Management and Budget control numbers assigned pursuant to the Paperwork Reduction Act. 30.63 Section 30.63 Commerce and Foreign... FOREIGN TRADE REGULATIONS General Administrative Provisions § 30.63 Office of Management and...

  10. Reduction in open field activity in the absence of memory deficits in the App(NL-G-F) knock-in mouse model of Alzheimer's disease.

    Science.gov (United States)

    Whyte, Lauren S; Hemsley, Kim M; Lau, Adeline A; Hassiotis, Sofia; Saito, Takashi; Saido, Takaomi C; Hopwood, John J; Sargeant, Timothy J

    2017-09-05

    The recent development of knock-in mouse models of Alzheimer's disease provides distinct advantages over traditional transgenic mouse models that rely on over-expression of amyloid precursor protein. Two such knock-in models that have recently been widely adopted by Alzheimer's researchers are the App(NL-F) and App(NL-G-F) mice. This study aimed to further characterise the behavioural phenotype and amyloid plaque distribution of App(NL-G-F/NL-G-F) (C57BL/6J background) mice at six-months of age. An attempt to replicate a previous study that observed deficits in working memory in the Y-maze, showed no difference between App(NL-G-F/NL-G-F) and wild-type mice. Further assessment of these mice using the novel object recognition test and Morris water maze also revealed no differences between App(NL-G-F/NL-G-F) and wild-type mice. Despite a lack of demonstrated cognitive deficits, we report a reduction in locomotor/exploratory activity in an open field. Histological examination of App(NL-G-F/NL-G-F) mice showed widespread distribution of amyloid plaques at this age. We conclude that whilst at six-months of age, memory deficits are not sufficiently robust to be replicated in varying environments, amyloid plaque burden is significant in App(NL-G-F/NL-G-F) knock-in brain. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Savannah River Site Footprint Reduction Results under the American Recovery and Reinvestment Act - 13302

    Energy Technology Data Exchange (ETDEWEB)

    Flora, Mary [Savannah River Nuclear Solutions Bldg. 730-4B, Aiken, SC 29808 (United States); Adams, Angelia [United States Department of Energy Bldg. 730-B, Aiken, SC 29808 (United States); Pope, Robert [United States Environmental Protection Agency Region IV Atlanta, GA 30303 (United States)

    2013-07-01

    The Savannah River Site (SRS) is an 802 square-kilometer United States Department of Energy (US DOE) nuclear facility located along the Savannah River near Aiken, South Carolina, managed and operated by Savannah River Nuclear Solutions. Construction of SRS began in the early 1950's to enhance the nation's nuclear weapons capability. Nuclear weapons material production began in the early 1950's, eventually utilizing five production reactors constructed to support the national defense mission. Past operations have resulted in releases of hazardous constituents and substances to soil and groundwater, resulting in 515 waste sites with contamination exceeding regulatory thresholds. More than 1,000 facilities were constructed onsite with approximately 300 of them considered radiological, nuclear or industrial in nature. In 2003, SRS entered into a Memorandum of Agreement with its regulators to accelerate the cleanup using an Area Completion strategy. The strategy was designed to focus cleanup efforts on the 14 large industrial areas of the site to realize efficiencies of scale in the characterization, assessment, and remediation activities. This strategy focuses on addressing the contaminated surface units and the vadose zone and addressing groundwater plumes subsequently. This approach streamlines characterization and remediation efforts as well as the required regulatory documentation, while enhancing the ability to make large-scale cleanup decisions. In February 2009, Congress approved the American Reinvestment and Recovery Act (ARRA) to create jobs and promote economic recovery. At SRS, ARRA funding was established in part to accelerate the completion of environmental remediation and facility deactivation and decommissioning (D and D). By late 2012, SRS achieved 85 percent footprint reduction utilizing ARRA funding by accelerating and coupling waste unit remediation with D and D of remnant facilities. Facility D and D activities were sequenced and

  12. Long-term effects of short-acting methylphenidate on growth rates of children with attention deficit hyperactivity disorder at Queen Sirikit National Institute of Child Health.

    Science.gov (United States)

    Moungnoi, Pranee; Maipang, Prinyaporn

    2011-08-01

    Methylphenidate (MPH) is generally considered to be first-line treatment for the core symptoms of Attention Deficit Hyperactivity Disorder (ADHD). Long-term administration of MPH in childhood may have adverse effects on growth. To determine the effect of long-term, short-acting MPH medication on growth. A retrospective descriptive study was employed by gathering the data of patients who were diagnosed as ADHD by child psychiatrists at the child and adolescent clinic, Queen Sirikit National Institute of Child Health. Subjects were patients received the first dose of short-acting methylphenidate from January 1st 2000 to December 31st 2007 and continued medication for at least 1 year. Data about height and weight were reviewed at the beginning of short-acting MPH medication, 6 months (mo), 1 yr, 2 yr, 3 yr, 4 yr, 5 yr, 6 yr and 7 yr interval. Collecting data was interpreted with INMU-Nutri Stat software program. Paired t-test was used to compare Z score of height and weight at different time points. There were 96 cases in the present study; the ratio of male to female was 3.6: 1. The first dose of short-acting methylphenidate was started at an average age of 8.62 +/- 1.70 years. Average drug dose ranged from 0.41-0.49 mg/kg/day. The data evaluated at 6 mo, 1 year 2 years, 3 years, 4 years and 5 years after drug use found that weight was not affected. Height decreased at 6 mo. after drug use (p < 0.05) but long-term treatment was not statistically significant. Prolonged medication with short-acting MPH has shown to have minimal impact on height only at the first 6 months; however, catch up growth was detected during adolescent period.

  13. 7 CFR 52.59 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 PROCESSED FRUITS AND VEGETABLES, PROCESSED PRODUCTS... sanitary rules and regulations of city, county, State, Federal, or other agencies having jurisdiction...

  14. [Antipsychotic medication change and reduction of rehospitalization in clients of ACT-J].

    Science.gov (United States)

    Satake, Naoko

    2011-01-01

    Polypharmacy and high-dose treatment of antipsychotics have been major problems in Japanese mental health. Although importance of simplifying prescription has been recognized, polypharmacy and high-dose medication especially for Schizophrenia remains prevalent. It's considered that psycho-social approach; for example, improvement of coping skills and social support such as care management can make reform of treatment efficiently and also improve patient's QOL. In ACT service, Medication, rehabilitation and social support work closely together and it could make prescription change even for SMI patients. Low-dose medication leads improvement of cognitive function and furthermore social activity. Considering the higher dose of antipsychotics prescribed concurrency in Japan, it's important to evaluate the change in medication for patients of ACT in Japan. We did one year follow up study about prescription change for 52 patients who have used ACT program at ACT-J team for more than one year at the end of December 2009. It was found that the dosage antipsychotics significantly decreased from 1131.3 mg converted to the relative potency equivalent of 100 mg of Chlorpromazine (CPZ eq), to 731.3 mg (CPZ eq) over the course of the 12 months. But there was no significant change about polyphamacy. Also it could be possible to reduce rehospitalization under the ACT program. Because recovery model could make improve not only drop out from psychiatric service, but user's dependency for hospitalization.

  15. Marked reduction of cerebellar deficits in upper limbs following transcranial cerebello-cerebral DC stimulation: tremor reduction and re-programming of the timing of antagonist commands

    Science.gov (United States)

    Grimaldi, Giuliana; Oulad Ben Taib, Nordeyn; Manto, Mario; Bodranghien, Florian

    2014-01-01

    Cerebellar ataxias represent a very heterogeneous group of disabling disorders for which we lack effective symptomatic therapies in most cases. There is currently an intense interest in the use of non-invasive transcranial DC stimulation (tDCS) to modulate the activity of the cerebellum in ataxic disorders. We performed a detailed laboratory assessment of the effects of transcranial cerebello-cerebral DC stimulation (tCCDCS, including a sham procedure) on upper limb tremor and dysmetria in 2 patients presenting a dominant spinocerebellar ataxia (SCA) type 2, one of the most common SCAs encountered during practice. Both patients had a very similar triplet expansion size in the ATXN2 gene (respectively, 39 and 40 triplets). tCCDCS reduced both postural tremor and action tremor, as confirmed by spectral analysis. Quadratical PSD (power spectral density) of postural tremor dropped to 38.63 and 41.42% of baseline values in patient 1 and 2, respectively. The integral of the subband 4–20 Hz dropped to 46.9 and 62.3% of baseline values, respectively. Remarkably, tCCDCS canceled hypermetria and reduced dramatically the onset latency of the antagonist EMG activity associated with fast goal-directed movements toward 3 aimed targets (0.2, 0.3, and 0.4 rad). Following tCCDCS, the latency dropped from 108–98 to 63–57 ms in patient 1, and from 74–87 to 41–46 ms in patient 2 (mean control values ± SD: 36 ± 8 to 45 ± 11 ms), corresponding to a major drop of z scores for the 2 patients from 7.12 ± 0.69 to 1.28 ± 1.27 (sham procedure: 6.79 ± 0.71). This is the first demonstration that tCCDCS improves upper limb tremor and hypermetria in SCA type 2. In particular, this is the first report of a favorable effect on the onset latency of the antagonist EMG activity, a neurophysiological marker of the defect in programming of timing of motor commands. Our results indicate that tCCDCS should be considered in the symptomatic management of upper limb motor deficits in

  16. 75 FR 37722 - OMB Approvals Under the Paperwork Reduction Act; Technical Amendment

    Science.gov (United States)

    2010-06-30

    ... center heading ``Polychlorinated Biphenyls (PCBs) Manufacturing, Processing, Distribution in Commerce.... * * * * * Polychlorinated Biphenyls (PCBs) Manufacturing, Processing, Distribution in Commerce, and Use Prohibitions Part....S.C. 136), and the Federal Food, Drug, and Cosmetic Act (FFDCA) (21 U.S.C. 408). Under PRA, 44 U.S.C...

  17. 77 FR 24730 - Submission of Information Collection Under the Paperwork Reduction Act; Reinstatement

    Science.gov (United States)

    2012-04-25

    ... background information on each person or entity having a financial interest in, or management responsibility... reinstatement of approval from the Office of Management and Budget for collection of information for the... Regulatory Act (IGRA) ; (2) approval of Class II background Investigation tribal licenses; (3) management...

  18. 75 FR 62326 - Magnuson-Stevens Act Provisions; Fishing Capacity Reduction Framework

    Science.gov (United States)

    2010-10-08

    ... be scrapped unless the Secretary certifies that the vessel will not be used for fishing in the waters... scrapped unless the Secretary certifies that the vessel will not be used for fishing in the waters of the U... high seas, or (3) In the waters of a foreign nation; or (B) Scrapping of all reduction vessels...

  19. Recovery Act: SeaMicro Volume Server Power Reduction Research Development

    Energy Technology Data Exchange (ETDEWEB)

    Gary Lauterbach

    2012-03-22

    Cloud data centers are projected to be the fastest growing segment of the server market through 2015, according to IDC. Increasingly people and businesses rely on the Cloud to deliver digital content quickly and efficiently. Recovery Act funding from the Department of Energy has helped SeaMicro's technologies enhance the total cost of operation, performance and energy efficiency in large data center and Cloud environments. SeaMicro's innovative supercomputer fabric connects thousands of processor cores, memory, storage and input/output traffic. The company's fabric supports multiple processor instruction sets. Current systems featuring SeaMicro technology typically use one quarter the power and take one sixth the space of traditional servers with the same compute performance, yet deliver up to 12 times the bandwidth per core. Mozilla and eHarmony are two customers successfully using SeaMicro's technology. Numerous non-public customers have been successfully using the SeaMicro product in test and production facilities. As a result of the Recovery Act funding from the U.S. Department of Energy, more than 50 direct jobs were created at SeaMicro. To date, they primarily have been high-value, engineering jobs. Hardware, software and manufacturing engineering positions have been created, as well as sales and sales engineering. The positions have allowed SeaMicro to significantly accelerate engineering development and accelerate commercialization. As a result, commercialization and delivery to market are months ahead of initial schedule. Additional jobs were indirectly created through the development of the SeaMicro product. Through many years of research and hard work prior to receipt of public funding, SeaMicro was awarded 2 patents for its work. SeaMicro's product led the way for industry leaders to reconsider the market for low power servers and create new product lines. With valuable support of the U.S. Department of Energy and through Sea

  20. Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study.

    Science.gov (United States)

    Coelho, Claudia; Figueiredo, Ricardo; Frank, Elmar; Burger, Julia; Schecklmann, Martin; Landgrebe, Michael; Langguth, Berthold; Elgoyhen, Ana Belen

    2012-01-01

    Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants acting on the central nervous system on tinnitus patients. Cyclobenzaprine at high (30 mg) and low doses (10 mg), orphenadrine (100 mg), tizanidine (24 mg) and eperisone (50 mg) were administered to a maximum of 20 patients per group over a 12-week period. High-dose cyclobenzaprine resulted in a significant reduction in the Tinnitus Handicap Inventory (THI) score between baseline and week 12 in the intention-to-treat sample. On the other hand, other treatments were not effective. These results were confirmed in an explorative analysis where baseline corrected THI and Clinical Global Impression scores at week 12 were compared between groups. The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials.

  1. Treating attention-deficit/hyperactivity disorder beyond symptom control alone in children and adolescents: a review of the potential benefits of long-acting stimulants.

    NARCIS (Netherlands)

    Buitelaar, J.K.; Medori, R.

    2010-01-01

    Attention-deficit/hyperactivity disorder (ADHD), one of the most common neuropsychiatric conditions of childhood, often has a chronic course and persists into adulthood in many individuals. ADHD may have a clinically important impact on health-related quality of life in children, a significant impac

  2. No Superiority of Treatment With Osmotic Controlled-Release Oral Delivery System-Methylphenidate Over Short/Medium-Acting Methylphenidate Preparations in the Rate and Timing of Injuries in Children With Attention-Deficit/Hyperactivity Disorder.

    Science.gov (United States)

    Golubchik, Pavel; Kodesh, Arad; Weizman, Abraham

    Methylphenidate (MPH) treatment in patients with attention-deficit/hyperactivity disorder (ADHD) is reported to reduce the risk for injuries. In the present study, the rate and timing of injuries were compared among the various MPH preparations (4 and 6-8 vs 12 hour-acting) in children with ADHD. This real-world retrospective study covered the years 2011 to 2013. Participants included 2042 youngsters (aged 4-18 years, 13.01 ± 3.2 years; 71.8% males and 28.2% females) diagnosed with ADHD according to the International Statistical Classification of Diseases, 10th Revision criteria and treated with various MPH preparations. They were divided into 2 groups by their treatment preparation as follows: MPH-immediate release (MPH-IR)-4 hour-acting pooled with MPH-slow release/long-acting (MPH-SR/LA)- 6 to 8 hour-acting versus osmotic controlled-release oral delivery system-MPH (OROS-MPH; Concerta)-12 hour-acting that consisted of pooling of OROS-MPH only and OROS-MPH combined with the other MPH preparations. The monthly rates of injury, specifically, late injury (occurrence between 4:00 p.m. to midnight) and for multiple injuries, the time interval between injuries, were assessed. No significant differences in monthly rate of nonfatal injuries were found between OROS-MPH with or without 4/6 to 8 hour-acting MPH-formulations versus only 4/6 to 8 hour-acting MPH-preparations (P = 0.53). Neither were differences found in the between-injury time interval (P = 0.83) or in late-injury-rates (P = 0.37) between those groups. This real-world-naturalistic study in the community demonstrates that, in ADHD pediatric populations, OROS-MPH preparation is not superior to short/medium-acting (4/6-8 hours) MPH preparations regarding the rate and timing of injuries.

  3. Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila.

    Science.gov (United States)

    Kanellopoulos, Alexandros K; Semelidou, Ourania; Kotini, Andriana G; Anezaki, Maria; Skoulakis, Efthimios M C

    2012-09-19

    Loss of the RNA-binding fragile X protein [fragile X mental retardation protein (FMRP)] results in a spectrum of cognitive deficits, the fragile X syndrome (FXS), while aging individuals with decreased protein levels present with a subset of these symptoms and tremor. The broad range of behavioral deficits likely reflects the ubiquitous distribution and multiple functions of the protein. FMRP loss is expected to affect multiple neuronal proteins and intracellular signaling pathways, whose identity and interactions are essential in understanding and ameliorating FXS symptoms. We used heterozygous mutants and targeted RNA interference-mediated abrogation in Drosophila to uncover molecular pathways affected by FMRP reduction. We present evidence that FMRP loss results in excess metabotropic glutamate receptor (mGluR) activity, attributable at least in part to elevation of the protein in affected neurons. Using high-resolution behavioral, genetic, and biochemical analyses, we present evidence that excess mGluR upon FMRP attenuation is linked to the cAMP decrement reported in patients and models, and underlies olfactory associative learning and memory deficits. Furthermore, our data indicate positive transcriptional regulation of the fly fmr1 gene by cAMP, via protein kinase A, likely through the transcription factor CREB. Because the human Fmr1 gene also contains CREB binding sites, the interaction of mGluR excess and cAMP signaling defects we present suggests novel combinatorial pharmaceutical approaches to symptom amelioration upon FMRP attenuation.

  4. 47 CFR 0.408 - OMB control numbers and expiration dates assigned pursuant to the Paperwork Reduction Act of 1995.

    Science.gov (United States)

    2010-10-01

    ... the Implementation of the Local Competition Provisions in the Telecommunications Act of 1996—CC Docket... Local Competition Provisions of the Telecommunications Act of 1996—CC Docket No. 96-98 01/31/11 3060... Applications) 02/28/11 3060-0844 Carriage of the Transmissions of Digital Television Broadcast Stations...

  5. 26 CFR 301.9100-6T - Time and manner of making certain elections under the Deficit Reduction Act of 1984.

    Science.gov (United States)

    2010-04-01

    ...(b)(3) Election to forgo carryback period by life insurance companies Losses from operations for... 1984. 1078 Election to exclude from gross income payments from U.S. Forest Service as result of... in accordance with chapter 62 of the Code. (iii) Time for making certain life insurance company...

  6. TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice.

    Science.gov (United States)

    Devi, L; Ohno, M

    2015-05-05

    Accumulating evidence shows that brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) significantly decrease early in Alzheimer's disease (AD). However, it remains unclear whether BDNF/TrkB reductions may be mechanistically involved in the pathogenesis of AD. To address this question, we generated 5XFAD transgenic mice with heterozygous TrkB knockout (TrkB(+/-)·5XFAD), and tested the effects of TrkB reduction on AD-like features in this mouse model during an incipient stage that shows only modest amyloid-β (Aβ) pathology and retains normal mnemonic function. TrkB(+/-) reduction exacerbated memory declines in 5XFAD mice at 4-5 months of age as assessed by the hippocampus-dependent spontaneous alternation Y-maze task, while the memory performance was not affected in TrkB(+/-) mice. Meanwhile, TrkB(+/-)·5XFAD mice were normal in nest building, a widely used measure for social behavior, suggesting the memory-specific aggravation of AD-associated behavioral impairments. We found no difference between TrkB(+/-)·5XFAD and 5XFAD control mice in cerebral plaque loads, Aβ concentrations including total Aβ42 and soluble oligomers and β-amyloidogenic processing of amyloid precursor protein. Interestingly, reductions in hippocampal expression of AMPA/NMDA glutamate receptor subunits as well as impaired signaling pathways downstream to TrkB such as CREB (cAMP response element-binding protein) and Akt/GSK-3β (glycogen synthase kinase-3β) were observed in TrkB(+/-)·5XFAD mice but not in 5XFAD mice. Among these signaling aberrations, only Akt/GSK-3β dysfunction occurred in TrkB(+/-) mice, while others were synergistic consequences between TrkB reduction and subthreshold levels of Aβ in TrkB(+/-)·5XFAD mice. Collectively, our results indicate that reduced TrkB does not affect β-amyloidosis but exacerbates the manifestation of hippocampal mnemonic and signaling dysfunctions in early AD.

  7. L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level.

    Science.gov (United States)

    Jamwal, Sumit; Singh, Shamsher; Gill, Jaskamal Singh; Kumar, Puneet

    2017-09-15

    L-theanine has been documented to possess anti-oxidant, anti-inflammatory and neuroprotective potential in various animal models of neurological disorders. The present study was anticipated to investigate the effect of L-theanine against quinolinic acid induced motor deficits, oxido-nitrosative stress, neuro-inflammation and neurotransmitters alteration in rats. Rats were stereotaxically injected QA (200nmol/2µl saline; intrastriatal); bilaterally on 0 day and L-theanine (25 & 50mg/kg; p.o.) was administered for 21 days starting from day 1 of QA injection. Either, L-NAME (10mg/kg; i.p.), a nitric oxide synthase inhibitor and L-arginine (50mg/kg; i.p.), a nitric oxide synthase precursor were administered with L-theanine in respective groups. Behavioral observations were evaluated on weekly basis using rota-rod, grip strength, narrow beam walking and open field test. QA treatment induces significant alteration in body weight, motor coordination, oxidative defense, pro-inflammatory cytokines and striatal neurotransmitters level. L-theanine treatment alone, at both the tested doses, significantly attenuated QA induced alterations. In addition, treatment of L-theanine with L-NAME significantly enhances the protective effect of L-theanine whereas treatment of L-theanine with L-arginine significantly ameliorated the protective effect of L-theanine. The protective effect of L-theanine is attributed to its anti-oxidant, anti-inflammatory and modulatory effect on nitric oxide pathway and neurotransmitters level in striatum. This suggests use of L-theanine in the clinical settings of HD. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Rhodium-Coordinated Poly(arylene-ethynylene)-alt-Poly(arylene-vinylene) Copolymer Acting as Photocatalyst for Visible-Light-Powered NAD+/NADH Reduction

    Science.gov (United States)

    2014-01-01

    A 2,2′-bipyridyl-containing poly(arylene-ethynylene)-alt-poly(arylene-vinylene) polymer, acting as a light-harvesting ligand system, was synthesized and coupled to an organometallic rhodium complex designed for photocatalytic NAD+/NADH reduction. The material, which absorbs over a wide spectral range, was characterized by using various analytical techniques, confirming its chemical structure and properties. The dielectric function of the material was determined from spectroscopic ellipsometry measurements. Photocatalytic reduction of nucleotide redox cofactors under visible light irradiation (390–650 nm) was performed and is discussed in detail. The new metal-containing polymer can be used to cover large surface areas (e.g. glass beads) and, due to this immobilization step, can be easily separated from the reaction solution after photolysis. Because of its high stability, the polymer-based catalyst system can be repeatedly used under different reaction conditions for (photo)chemical reduction of NAD+. With this concept, enzymatic, photo-biocatalytic systems for solar energy conversion can be facilitated, and the precious metal catalyst can be recycled. PMID:25130570

  9. "The safety of sodium reduction in the food supply: A cross-discipline balancing act"-Workshop proceedings.

    Science.gov (United States)

    Taylor, Christine; Doyle, Michael; Webb, Densie

    2017-03-28

    This workshop, jointly presented by the ILSI North America Technical Committees on Food Microbiology and Sodium, aimed to provide greater knowledge and appreciation of the opportunities and challenges facing the food industry in answering the public health community's call to reduce sodium levels in the food supply. One major challenge is finding effective substitutes for the various antimicrobial and functional roles that sodium plays across different food categories. Sodium plays a critical role in retarding the growth of pathogens and food spoilage bacteria. Moreover, taste is an important factor for consumers when they choose food products, and the flavor changes that occur when salt is reduced or replaced must be considered and ingredients and processes adjusted accordingly. The workshop provided a platform for a multidisciplinary discussion among the microbiology, food science, nutrition, and public health communities to share progress and propose solutions, including the formation of public-private partnerships, to develop coordinated and comprehensive strategies. This paper provides an overview of the issues raised, rather than a specific summary of workshop discussions. The Food and Drug Administration's Draft Guidance for Industry on voluntary sodium reduction and the 2015 US Dietary Guidelines for Americans were released subsequent to the workshop and are also discussed.

  10. Electroencephalography reveals lower regional blood perfusion and atrophy of the temporoparietal network associated with memory deficits and hippocampal volume reduction in mild cognitive impairment due to Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Moretti DV

    2015-02-01

    Full Text Available Davide Vito MorettiNational Institute for the research and cure of Alzheimer’s disease, S. John of God, Fatebenefratelli, Brescia, Italy Background: An increased electroencephalographic (EEG upper/lower alpha power ratio has been associated with less regional blood perfusion, atrophy of the temporoparietal region of the brain, and reduction of hippocampal volume in subjects affected by mild cognitive impairment due to Alzheimer’s disease as compared with subjects who do not develop the disease. Moreover, EEG theta frequency activity is quite different in these groups. This study investigated the correlation between biomarkers and memory performance.Methods: EEG α3/α2 power ratio and cortical thickness were computed in 74 adult subjects with prodromal Alzheimer’s disease. Twenty of these subjects also underwent assessment of blood perfusion by single-photon emission computed tomography (SPECT. Pearson’s r was used to assess the correlation between cortical thinning, brain perfusion, and memory impairment.Results: In the higher α3/α2 frequency power ratio group, greater cortical atrophy and lower regional perfusion in the temporoparietal cortex was correlated with an increase in EEG theta frequency. Memory impairment was more pronounced in the magnetic resonance imaging group and SPECT groups.Conclusion: A high EEG upper/low alpha power ratio was associated with cortical thinning and less perfusion in the temporoparietal area. Moreover, atrophy and less regional perfusion were significantly correlated with memory impairment in subjects with prodromal Alzheimer’s disease. The EEG upper/lower alpha frequency power ratio could be useful for identifying individuals at risk for progression to Alzheimer’s dementia and may be of value in the clinical context.Keywords: electroencephalography, perfusion, atrophy, temporoparietal network, memory deficits, hippocampal volume, mild cognitive impairment, Alzheimer’s disease

  11. Regional Decomposition of Carbon Reduction Target and Its Pattern of Surplus and Deficit in Guangdong Province%广东省碳减排总量目标的地区分解及其盈亏格局

    Institute of Scientific and Technical Information of China (English)

    林文声; 胡新艳

    2014-01-01

    Making a study on the accounting model of carbon emissions and dynamic optimal model of endogenous economic growth, this paper uses the data of carbon emissions from 1985 to 2020 in Guangdong Province and its cities, introduces the idea of “carbon budget” according to the set scenarios of the reduction targets of carbon emissions, which takes the principles of equitable distribution of per capita carbon emissions and historical responsibility for carbon emissions into account, decomposes carbon emission reduction targets regionally, calculates the carbon emissions quotas of the cities in the Province, and estimates the pattern of surplus and deficit of carbon emissions in future periods, preliminarily simulates the basis of “Trading the Rights of Carbon Emissions” among the cities. It shows that: Firstly, the cumulative quotas of carbon emissions in Guangdong Province for the period from 1985 to 2020 are between 5 246.591 9 million tons and 5 425.185 7 million tons, and per capita quotas of carbon emission are between 57.065 5 tons and 59.008 0 tons. Per capita quotas of carbon emission, population and the cumulative history of carbon emissions are the decisive factors in allocation result of carbon emission rights of the cities in the Province. Population movements will affect the number of regional carbon emissions. After the assessment year, the reducing of total regional population will ease the pressure of carbon emissions, and vice versa. Secondly, there are seven cities, which are mainly distributed in the economically developed Pearl River Delta region, emitting carbon beyond the carbon budget quota standards. Those cities can be ranked in order of their deficits from large to small:Guangzhou, Shenzhen, Foshan, Dongguan, Zhuhai, Zhongshan and Huizhou. Meanwhile, there are 14 cities, mainly located in the east, west and the north areas of the Province, have carbon budget surpluses. According to their surpluses from large to small, those cities are

  12. Long-acting methylphenidate-OROS in youths with attention-deficit hyperactivity disorder suboptimally controlled with immediate-release methylphenidate : a study of cost effectiveness in The Netherlands

    NARCIS (Netherlands)

    Faber, Adrianne; van Agthoven, Michel; Kalverdijk, Luuk J; Tobi, Hiltje; de Jong-van den Berg, Lolkje T W; Annemans, Lieven; Postma, Maarten J

    2008-01-01

    Background: Attention-deficit hyperactivity disorder (ADHD) is the most common mental health disorder in youths. Stimulants are the drugs of first choice in the treatment of ADHD. It has been suggested that full costs associated with the treatment of ADHD may be reduced by once-daily administration

  13. Long-acting methylphenidate-OROS in youths with attention-deficit hyperactivity disorder suboptimally controlled with immediate-release methylphenidate : a study of cost effectiveness in The Netherlands

    NARCIS (Netherlands)

    Faber, Adrianne; van Agthoven, Michel; Kalverdijk, Luuk J; Tobi, Hiltje; de Jong-van den Berg, Lolkje T W; Annemans, Lieven; Postma, Maarten J

    2008-01-01

    Background: Attention-deficit hyperactivity disorder (ADHD) is the most common mental health disorder in youths. Stimulants are the drugs of first choice in the treatment of ADHD. It has been suggested that full costs associated with the treatment of ADHD may be reduced by once-daily administration

  14. Long-Acting Methylphenidate-OROS in Youths with Attention-Deficit Hyperactivity Disorder Suboptimally Controlled with Immediate-Release Methylphenidate. A study of cost effectiveness in The Netherlands.

    NARCIS (Netherlands)

    Faber, A.; Agthoven, van M.; Kalverdijk, L.J.; Tobi, H.; Jong-van den Berg, de L.T.W.; Annemans, L.; Postma, M.J.

    2008-01-01

    BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is the most common mental health disorder in youths. Stimulants are the drugs of first choice in the treatment of ADHD. It has been suggested that full costs associated with the treatment of ADHD may be reduced by once-daily administration

  15. ALTERNATIVE STRATEGIES TO REDUCE PUBLIC DEFICITS: THE CASE OF SPAIN

    Directory of Open Access Journals (Sweden)

    O. Bajo-Rubio

    2013-03-01

    Full Text Available High government deficits are a matter of concern in many European countries. We examine the effects of several alternative measures intended to reduce public deficits, distinguishing between those acting through either taxes or spending. Our analysis is applied to the Spanish economy, using a computable general equilibrium model.

  16. Attention deficit hyperactivity disorder (ADHD

    Directory of Open Access Journals (Sweden)

    Fabio de Almeida Bolognani

    2011-07-01

    Full Text Available The objective of this study, stated as Previous Notation, is to demonstrate that Attention Deficit Hyperactivity Disorder Pathology presents a differentiated condition in carriers where a significant percentage, close to 60%, present a higher level of zinc elimination by kidneys. In this study, a direct relation of Zinc Mettalicum pathogenetic symptoms, this disturbance and the elimination of this element which participates in neurotransmission process were identified, and the relation with elements from regular diet, which can act as zinc chelating agents would be involved in the evolution of this disturbance, justifying the issue of individual susceptibility, essential in homeopathic investigation

  17. Dealing With a Deficit

    Institute of Scientific and Technical Information of China (English)

    LAN XINZHEN

    2010-01-01

    @@ For the first time since April 2004,China experienced a monthly trade deficit as imports surpassed exports.Statistics released by the General Administration of Customs on April 10 showed China's export and import volume reached $112.11billion and $119.35 billion in March,respectively,leading to a trade deficit of $7.24 billion.

  18. Attention Deficit Hyperactivity Disorder

    Science.gov (United States)

    ... If so, your child may have attention deficit hyperactivity disorder (ADHD). Nearly everyone shows some of these ... children. The main features of ADHD are Inattention Hyperactivity Impulsivity No one knows exactly what causes ADHD. ...

  19. Understanding Attention Deficit Disorders.

    Science.gov (United States)

    Villegas, Orlando; And Others

    This booklet provides basic information regarding attention deficit hyperactivity disorders (ADHD), in their separate modalities, with hyperactivity, impulsivity, and inattention. Explanations are offered concerning short attention span, impulsive behavior, hyperactivity, and beginning new activities before completing the previous one. Theories…

  20. Disentangling deficits in adults with attention-deficit/hyperactivity disorder.

    NARCIS (Netherlands)

    Bekker, E.M.; Overtoom, C.C.; Kooij, J.J.; Buitelaar, J.K.; Verbaten, M.N.; Kenemans, J.L.

    2005-01-01

    CONTEXT: A lack of inhibitory control has been suggested to be the core deficit in attention-deficit/hyperactivity disorder (ADHD), especially in adults. This means that a primary deficit in inhibition mediates a cascade of secondary deficits in other executive functions, such as attention. Impaired

  1. Remediation of attention deficits in head injury.

    Directory of Open Access Journals (Sweden)

    Nag S

    1999-01-01

    Full Text Available Head injury is associated with psychological sequelae which impair the patient′s psychosocial functioning. Information processing, attention and memory deficits are seen in head injuries of all severity. We attempted to improve deficits of focused, sustained and divided attention. The principle of overlapping sources of attention resource pools was utilised in devising the remediation programme. Tasks used simple inexpensive materials. Four head injured young adult males with post concussion syndrome underwent the retraining program for one month. The patients had deficits of focused, sustained and divided attention parallel processing, serial processing, visual scanning, verbal learning and memory and working memory. After the retraining programme the deficits of attention improved in the four patients. Serial processing improved in two patients. Parallel processing and neuropsychological deficits did not improve in any patient. The symptom intensity reduced markedly and behavioural functioning improved in three of the four patients. The results supported an association between improving attention and reduction of symptom intensity. Attention remediation shows promise as a cost effective, time efficient and simple technique to improve the psychological and psychosocial functioning of the head injured patient.

  2. Acute IPPS - Readmissions Reduction Program

    Data.gov (United States)

    U.S. Department of Health & Human Services — Section 3025 of the Affordable Care Act added section 1886(q) to the Social Security Act establishing the Hospital Readmissions Reduction Program, which requires CMS...

  3. An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP

    Science.gov (United States)

    Siegenthaler, Kevin D; Pareja, Kristeen A; Wang, Jie; Sevier, Carolyn S

    2017-01-01

    Unfavorable redox conditions in the endoplasmic reticulum (ER) can decrease the capacity for protein secretion, altering vital cell functions. While systems to manage reductive stress are well-established, how cells cope with an overly oxidizing ER remains largely undefined. In previous work (Wang et al., 2014), we demonstrated that the chaperone BiP is a sensor of overly oxidizing ER conditions. We showed that modification of a conserved BiP cysteine during stress beneficially alters BiP chaperone activity to cope with suboptimal folding conditions. How this cysteine is reduced to reestablish 'normal' BiP activity post-oxidative stress has remained unknown. Here we demonstrate that BiP's nucleotide exchange factor – Sil1 – can reverse BiP cysteine oxidation. This previously unexpected reductant capacity for yeast Sil1 has potential implications for the human ataxia Marinesco-Sjögren syndrome, where it is interesting to speculate that a disruption in ER redox-signaling (due to genetic defects in SIL1) may influence disease pathology. DOI: http://dx.doi.org/10.7554/eLife.24141.001 PMID:28257000

  4. Pragmatic comprehension deficit in Parkinson's disease.

    Science.gov (United States)

    Holtgraves, Thomas; McNamara, Patrick

    2010-04-01

    Recognizing the specific speech act (Searle, 1969) that a speaker performs with an utterance is a fundamental feature of pragmatic competence. However, little is known about neurocognitive mediation of speech act comprehension. The present research examined the extent to which people with Parkinson's disease (PD) comprehend specific speech acts. In the first experiment, participants read conversational utterances and then performed a lexical decision task (decide whether a target string of letters was a word). Consistent with past research, nonimpaired participants performed this task more quickly when the target string was the speech act associated with the preceding utterance. In contrast, people with PD did not demonstrate this effect, suggesting that speech act activation is slowed or is not an automatic component of comprehension for people with PD. In a second study, participants were given unlimited time to indicate their recognition of the speech act performed with an utterance. PD participants were significantly poorer at this task than were control participants. We conclude that a previously undocumented language disorder exists in PD and that this disorder involves a selective deficit in speech act comprehension. Frontostriatal systems (the systems impaired in PD) likely contribute to normal speech act comprehension.

  5. Direct-acting Antivirals in Kidney Transplant Patients: Successful Hepatitis C Treatment and Short Term Reduction in Urinary Protein/Creatinine Ratios

    Directory of Open Access Journals (Sweden)

    Michael R. Goetsch

    2017-09-01

    Full Text Available Introduction: The role of Hepatitis C Virus (HCV clearance in long-term kidney graft survival is unknown. In this study, we examined short-term trends of urinary protein/creatinine (P/C ratios in a cohort of HCV-infected kidney transplant recipients with stable graft function and treated with direct-acting antivirals (DAAs. Methods: We conducted a retrospective study of 19 kidney transplant patients with chronic HCV infection treated with DAAs at the University of Alabama at Birmingham 1917 Viral Hepatitis Clinic between January 2013 and June 2016. Markers of glomerular damage were assessed using average protein/creatinine (P/C ratios measured pre- and post-treatment. We also described treatment efficacy using sustained virologic response at 12 weeks post-HCV treatment (SVR12. Results: The median age of the 19 patients included was 59 years (Q1=58, Q3=64 at completion of treatment. Of these patients, 68% were African American, 32% were White and 63% were male. The median time between kidney transplant and initiation of DAA therapy was 2.25 years (Q1=0.79, Q3=3.79. Post-treatment P/C ratios (median=0.127, Q1=0.090, Q3=0.220 were significantly lower (p=0.01 than pre-treatment ratios (median=0.168, Q1=0.118, Q3=0.385. P/C ratios decreased in 14 of 19 patients (74% with median change of -0.072 (median percent change= -40%. Post-treatment eGFRs (median=58.9, Q1=48.9, Q3=72.3 were not significantly different (p=0.82 than the pre-treatment values (median=57.0, Q1=48.8, Q3=67.8. Conclusions: In this preliminary study, there was a statistically significant decrease in P/C ratios associated with HCV clearance, suggesting a potential role for DAAs in improving kidney graft survival. Larger cohort studies will be needed to assess the clinical and long-term benefits of DAAs in this special population of HCV infected patients.

  6. Attention deficit hyperactivity disorder (ADHD)

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/001551.htm Attention deficit hyperactivity disorder To use the sharing features on this page, please enable JavaScript. Attention deficit hyperactivity disorder (ADHD) is a problem caused ...

  7. Quantum measurement act as a "speech act"

    CERN Document Server

    Schneider, J

    2005-01-01

    I show that the quantum measurement problem can be understood if the measurement is seen as a ``speech act'' in the sense of modern language theory. The reduction of the state vector is in this perspective an intersubjectice -- or better a-subjective -- symbolic process. I then give some perspectives on applications to the ``Mind-Body problem''.

  8. Gray matter reduction in the vermis and CRUS-II is associated with social and interaction deficits in low-functioning children with autistic spectrum disorders: a VBM-DARTEL Study.

    Science.gov (United States)

    Riva, Daria; Annunziata, Silvia; Contarino, Valeria; Erbetta, Alessandra; Aquino, Domenico; Bulgheroni, Sara

    2013-10-01

    Voxel-based morphometry (VBM) studies have reported abnormalities in brain regions involved in functions that are commonly impaired in autism spectrum disorders (ASD). However, little is known about brain structure anomalies in low-functioning (LF) young children with ASD. A VBM analysis was carried out to assess brain regions involved in ASD LF children, and a multiple regression analysis was used to examine the relationship between regional volume changes and autism symptom measures. Twenty-six LF ASD children (2-10 years) were compared with 21 controls. A VBM-Diffeomorphic Anatomical Registration analysis using Exponentiated Lie algebra (DARTEL) was used to evaluate gray matter (GM) and white matter alterations, covaried with Intelligence Quotient, age, and total brain volume. The resulting altered regions were correlated with Autism Diagnostic Interview (ADI)-Revised and Autism Diagnostic Observation Schedule (ADOS)-Generic scores. GM bilateral reduction was noted in the cerebellum (Crus II and vermis) and in the hippocampi in ASD group. GM reduction was also detected in the inferior and superior frontal gyri, in the occipital medial and superior gyri, and in the inferior temporal gyrus of the left cerebral hemisphere. In the right hemisphere, GM reduction was found in the post-central cortex and in the occipital inferior gyrus. Multiple regression analysis showed a correlation between alterations in GM volume in the cerebellum (Crus II and vermis) and ADI-communication and ADOS-total (communication and interaction) scores. These findings seem to confirm that the cerebellum is involved in integrating and regulating emotional and cognitive functions which are impaired in ASD.

  9. Privacy Act

    Science.gov (United States)

    Learn about the Privacy Act of 1974, the Electronic Government Act of 2002, the Federal Information Security Management Act, and other information about the Environmental Protection Agency maintains its records.

  10. Beyond the knowledge deficit

    DEFF Research Database (Denmark)

    Hansen, Janus Staffan; Holm, Lotte; Frewer, Lynn

    2003-01-01

    The paper reviews psychological and social scientific research on lay attitudes to food risks. Many experts (scientists, food producers and public health advisors) regard public unease about food risks as excessive. This expert-lay discrepancy is often attributed to a 'knowledge deficit' among lay...... people. However, much research in psychology and sociology suggests that lay risk assessments are complex, situationally sensitive expressions of personal value systems. The paper is organised around four themes: risk perception, the communication of risk, lay handling of risk, and public trust...... in institutions and experts. It suggests that an interdisciplinary, contextualised and psychologically sound approach to the study of risk is needed....

  11. Neurofibromatozis and Attention Deficit

    Directory of Open Access Journals (Sweden)

    Mehmet ERYILMAZ et al.

    2010-05-01

    Full Text Available Neurofibromatosis type VI, a disease characterized by the presence of café-au-lait spots withoutthe presence of neurofibromas typically present in neurofibromatosis, as well as cognitivefunction and speech problems, often shows neurological involvement. We describe a case of a14-year-old child who has speech problems and isolated cafè-au-lait macules. We performedan IQ test on him and he scored 70 points. His problems started when he was approximately 5years old (school age. He was diagnosed with attention deficit disorder syndrome withouthyperactivity after neuropsychiatric investigation. We reported this case to improve recognitionof NF VI in children who have cognitive function problems.

  12. Buffering growth variations against water deficits through timely carbon usage.

    Science.gov (United States)

    Pantin, Florent; Fanciullino, Anne-Laure; Massonnet, Catherine; Dauzat, Myriam; Simonneau, Thierry; Muller, Bertrand

    2013-01-01

    Water stresses reduce plant growth but there is no consensus on whether carbon metabolism has any role in this reduction. Sugar starvation resulting from stomatal closure is often proposed as a cause of growth impairment under long-term or severe water deficits. However, growth decreases faster than photosynthesis in response to drought, leading to increased carbohydrate stores under short-term or moderate water deficits. Here, we addressed the question of the role of carbon availability on growth under moderate water deficits using two different systems. Firstly, we monitored the day/night pattern of leaf growth in Arabidopsis plants. We show that a moderate soil water deficit promotes leaf growth at night in mutants severely disrupted in their nighttime carbohydrate availability. This suggests that soil water deficit promotes carbon satiation. Secondly, we monitored the sub-hourly growth variations of clementine fruits in response to daily, natural fluctuations in air water deficit, and at contrasting source-sink balances obtained by defoliation. We show that high carbohydrate levels prevent excessive, hydraulic shrinkage of the fruit during days with high evaporative demand, most probably through osmotic adjustment. Together, our results contribute to the view that growing organs under moderate soil or air water deficit are not carbon starved, but use soluble carbohydrate in excess to partly release a hydromechanical limitation of growth.

  13. Buffering growth variation against water deficits through timely carbon usage

    Directory of Open Access Journals (Sweden)

    Florent ePantin

    2013-11-01

    Full Text Available Water stresses reduce plant growth but there is no consensus on whether carbon metabolism has any role in this reduction. Sugar starvation resulting from stomatal closure is often proposed as a cause of growth impairment under long-term or severe water deficits. However, growth decreases faster than photosynthesis in response to drought, leading to increased carbohydrate stores under short-term or moderate water deficits. Here, we addressed the question of the role of carbon availability on growth under moderate water deficits using two different systems. Firstly, we monitored the day/night pattern of leaf growth in Arabidopsis plants. We show that a moderate soil water deficit promotes leaf growth at night in mutants severely disrupted in their nighttime carbohydrate availability. This suggests that soil water deficit promotes carbon satiation. Secondly, we monitored the sub-hourly growth fluctuations of clementine fruits in response to daily, natural fluctuation in air water deficit, and at contrasting source-sink balance obtained by defoliation. We show that high carbohydrate levels obtained under favourable source-sink balance prevent excessive, hydraulic shrinkage of the fruit during days with high evaporative demand, most probably by modulating osmotic adjustment. Together, our results contribute to the view that growing organs under moderate soil or air water deficit are not carbon starved, but use soluble carbohydrate in excess to partly release a hydromechanical limitation of growth.

  14. ACTS 2014

    DEFF Research Database (Denmark)

    Co-curator of ACTS 2014 together with Rasmus Holmboe, Judith Schwarzbart and Sanne Kofoed. ACTS is the Museum of Contemporary Art’s international bi-annual festival. ACTS was established in 2011 and, while the primary focus is on sound and performance art, it also looks toward socially oriented art...... various possibilities and public spaces as a stage. ACTS takes place in and around the museum and diverse locations in Roskilde city. ACTS is partly curated by the museum staff and partly by guest curators. ACTS 2014 is supported by Nordea-fonden and is a part of the project The Museum goes downtown....

  15. Ischemia may be the primary cause of the neurologic deficits in classic migraine

    DEFF Research Database (Denmark)

    Skyhøj Olsen, T; Friberg, L; Lassen, N A

    1987-01-01

    This study investigates whether the cerebral blood flow reduction occurring in attacks of classic migraine is sufficient to cause neurologic deficits. Regional cerebral blood flow measured with the xenon 133 intracarotid injection technique was analyzed in 11 patients in whom a low-flow area...... ischemia and neurologic deficits. Hence, this study suggests a vascular origin of the prodromal neurologic deficits that may accompany attacks of classic migraine....

  16. Deficit in automatic sound-change detection may underlie some music perception deficits after acute hemispheric stroke.

    Science.gov (United States)

    Kohlmetz, C; Altenmüller, E; Schuppert, M; Wieringa, B M; Münte, T F

    2001-01-01

    Music perception deficits following acute neurological damage are thought to be rare. By a newly devised test battery of music-perception skills, however, we were able to identify among a group of 12 patients with acute hemispheric stroke six patients with music perception deficits (amusia) while six others had no such deficits. In addition we recorded event-related brain potentials (ERPs) in a passive listening task with frequent standard and infrequent pitch deviants designed to elicit the mismatch negativity (MMN). The MMN in the patients with amusia was grossly reduced, while the non-amusic patients and control subjects had MMNs of equal size. These data show that amusia is quite common in unselected stroke patients. The MMN reduction suggests that amusia is related to unspecific automatic stimulus classification deficits in these patients.

  17. Attention deficit hyperactivity disorder.

    Science.gov (United States)

    Kulkarni, Madhuri

    2015-03-01

    Attention Deficit Hyperactivity Disorder (ADHD) is a common behavioral disorder in children. It is characterized by motor hyperactivity, impulsivity and inattention inappropriate for the age. Approximately 5-10 % of school age children are diagnosed to have ADHD. The affected children show significant impairment in social behavior and academic performance. The DSM-5 criteria are useful in diagnosing three subtypes of ADHD based on presence of symptoms described in 3 domains viz ., inattention, hyperactivity and impulsivity. Co-morbidities like specific learning disability, anxiety disorder, oppositional defiant disorder are commonly associated with ADHD.Education of parents and teachers, behavioral therapy and medication are main components of management. Methylphenidate and Atomoxetine are effective in controlling symptoms of ADHD in most children. Research studies estimated that 30-60 % of children continue to show symptoms of ADHD in adulthood. The general practitioner can play an important role in early diagnosis, appropriate assessment and guiding parents for management of children with ADHD.

  18. Attention Deficit Hyperactivity Disorder Symptoms Mediate Early-Onset Smoking

    NARCIS (Netherlands)

    Huizink, A.C.; Lier, P.A.C. van; Crijnen, A.A.M.

    2009-01-01

    Background/Aims: Symptoms of attention deficit hyperactivity disorder (ADHD) have often been associated with early-onset smoking. We hypothesize that reductions in ADHD symptoms due to an intervention have a mediating effect on early-onset smoking. Methods: In a universal, school-based, randomized c

  19. Attention deficit hyperactivity disorder symptoms mediate early-onset smoking

    NARCIS (Netherlands)

    Huizink, A.C.; Van Lier, P.A.C.; Crijnen, A.A.M.

    2009-01-01

    Background/Aims: Symptoms of attention deficit hyperactivity disorder (ADHD) have often been associated with early-onset smoking. We hypothesize that reductions in ADHD symptoms due to an intervention have a mediating effect on early-onset smoking. Methods: In a universal, school-based, randomized c

  20. Attention deficit hyperactivity disorder symptoms mediate early-onset smoking

    NARCIS (Netherlands)

    A.C. Huizink (Anja); P.A.C. van Lier (Pol); A.A.M. Crijnen (Alfons)

    2008-01-01

    textabstractBackground/Aims: Symptoms of attention deficit hyperactivity disorder (ADHD) have often been associated with early-onset smoking. We hypothesize that reductions in ADHD symptoms due to an intervention have a mediating effect on early-onset smoking. Methods: In a universal, school-based,

  1. "A Balancing Act: How to End America's Trade Deficits"

    OpenAIRE

    2010-01-01

    Now that America's financial institutions have been brought back from the brink, the greatest threat to global economic stability is the gigantic trade imbalance between the United States, China, and other trading partners. A second big threat to economic stability, in the longer run, is global warming. Both problems are related to America's addiction to cheap imports and foreign oil—bad habits that a clever cap-and-trade system could help us kick at last.

  2. Dyscalculia and Attention Deficit Subtypes

    OpenAIRE

    1999-01-01

    The association of specific academic deficits with attention deficit disorder (ADD) subtypes was determined in 20 students (ages 8-12) with ADD with hyperactivity (ADD/H) compared to 20 with ADD without hyperactivity (ADD/noH), at the Department of Educational Psychology, University of Texas at Austin, TX.

  3. Faking attention deficit hyperactivity disorder.

    Science.gov (United States)

    Sansone, Randy A; Sansone, Lori A

    2011-08-01

    Attention-deficit hyperactivity disorder is a common malady in the general population, with up to 8.1 percent of adults meeting criteria for this syndrome. In the college setting, the diagnosis of attention deficit hyperactivity disorder may offer specific academic advantages. Once the diagnosis is assigned, the prescription of stimulant medication may provide additional secondary gains through misuse and/or diversion. For example, these drugs may be used by college consumers to increase alertness, energy, academic performance, and athletic performance. Stimulants may also decrease psychological distress, alleviate restlessness and weight concerns, and be used for recreational purposes. According to the findings of five studies, the symptoms of attention deficit hyperactivity disorder can be believably faked, particularly when assessed with attention deficit hyperactivity disorder symptom checklists. Thus, the faking of attention deficit hyperactivity disorder is a realistic concern in both psychiatric and primary care settings.

  4. The congressional viewpoint: Deficit reduction and risk legislation

    Energy Technology Data Exchange (ETDEWEB)

    Chakoff, H.E.

    1995-12-31

    This presentation will provide a current congressional status of legislation related to low-level waste and DOE cleanup. Key legislation discussed will include S. 755 for Privatization of the Uranium Enrichment Corporation and the markup of H.R. 1020, the Nuclear Waste Legislation. In addition, the session will include a discussion of legislation related to the approval of the Texas compact.

  5. Pragmatic communication deficits in children with epilepsy

    NARCIS (Netherlands)

    Broeders, Mark; Geurts, Hilde; Jennekens-Schinkel, Aag

    2010-01-01

    Background: Various psychiatric and neurological disorders including epilepsy have been associated with language deficits. Pragmatic language deficits, however, have seldom been the focus of earlier studies in children with epilepsy. Moreover, it is unknown whether these pragmatic deficits are relat

  6. Functional and structural deficits at accumbens synapses in a mouse model of Fragile X

    Directory of Open Access Journals (Sweden)

    Daniela eNeuhofer

    2015-03-01

    Full Text Available Fragile X is the most common cause of inherited intellectual disability and a leading cause of autism. The disease is caused by mutation of a single X-linked gene called fmr1 that codes for the Fragile X mental retardation protein (FMRP, a 71 kDa protein, which acts mainly as a translation inhibitor. Fragile X patients suffer from cognitive and emotional deficits that coincide with abnormalities in dendritic spines. Changes in spine morphology are often associated with altered excitatory transmission and long-term plasticity, the most prominent deficit in fmr1-/y mice. The nucleus accumbens, a central part of the mesocortico-limbic reward pathway, is now considered as a core structure in the control of social behaviors. Although the socio-affective impairments observed in Fragile X suggest dysfunctions in the accumbens, the impact of the lack of FMRP on accumbal synapses has scarcely been studied. Here we report for the first time a new spike timing-dependent plasticity paradigm that reliably triggers NMDAR-dependent long-term potentiation (LTP of excitatory afferent inputs of medium spiny neurons (MSN in the nucleus accumbens core region. Notably, we discovered that this LTP was completely absent in fmr1-/y mice. In the fmr1-/y accumbens intrinsic membrane properties of MSNs and basal excitatory neurotransmission remained intact in the fmr1-/y accumbens but the deficit in LTP was accompanied by an increase in evoked AMPA/NMDA ratio and a concomitant reduction of spontaneous NMDAR-mediated currents. In agreement with these physiological findings, we found significantly more filopodial spines in fmr1-/y mice by using an ultrastructural electron microscopic analysis of accumbens core medium spiny neuron spines. Surprisingly, spine elongation was specifically due to the longer longitudinal axis and larger area of spine necks, whereas spine head morphology and postsynaptic density size on spine heads remained unaffected in the fmr1-/y accumbens

  7. [Attention deficit hyperactivity disorder].

    Science.gov (United States)

    Cunill, Ruth; Castells, Xavier

    2015-04-20

    Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorders and can persist into the adulthood. ADHD has important social, academic and occupational consequences. ADHD diagnosis is based on the fulfillment of several clinical criteria, which can vary depending on the diagnostic system used. The clinical presentation can show great between-patient variability and it has been related to a dysfunction in the fronto-striatal and meso-limbic circuits. Recent investigations support a model in which multiple genetic and environmental factors interact to create a neurobiological susceptibility to develop the disorder. However, no clear causal association has yet been identified. Although multimodal treatment including both pharmacological and psychosocial interventions is usually recommended, no convincing evidence exists to support this recommendation. Pharmacological treatment has fundamentally shown to improve ADHD symptoms in the short term, while efficacy data for psychosocial interventions are scarce and inconsistent. Yet, drug treatment is increasingly popular and the last 2 decades have witnessed a sharp increase in the prescription of anti-ADHD medications coinciding with the marketing of new drugs to treat ADHD.

  8. Adults with attention-deficit/hyperactivity disorder - a brain magnetic resonance spectroscopy study

    DEFF Research Database (Denmark)

    Dramsdahl, Margaretha; Ersland, Lars; Plessen, Kerstin J

    2011-01-01

    Background: Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the right midfrontal region including the anterior cingulate cortex in adults...... groups. Results: The ADHD group showed a significant reduction of Glu/Cre in the left midfrontal region compared to the controls. Conclusion: The reduction of Glu/Cre in the left midfrontal region in the ADHD group may reflect a glutamatergic deficit in prefrontal neuronal circuitry in adults with ADHD...

  9. WATER MANAGEMENT STRATEGIES UNDER DEFICIT IRRIGATION

    Directory of Open Access Journals (Sweden)

    Antonino Capra

    2008-12-01

    Full Text Available Deficit irrigation (DI is an optimization strategy whereby net returns are maximized by reducing the amount of irrigation water; crops are deliberated allowed to sustain some degree of water deficit and yield reduction. Although the DI strategy dates back to the 1970s, this technique is not usually adopted as a practical alternative to full irrigation by either academics or practitioners. Furthermore, there is a certain amount of confusion regarding its concept. In fact, a review of recent literature dealing with DI has shown that only a few papers use the concept of DI in its complete sense (e.g. both the agronomic and economic aspects. A number of papers only deal with the physiological and agronomical aspects of DI or concern techniques such as Regulated Deficit Irrigation (RDI and Partial Root Drying (PRD. The paper includes two main parts: i a review of the principal water management strategies under deficit conditions (e.g. conventional DI, RDI and PRD; and ii a description of a recent experimental research conducted by the authors in Sicily (Italy that integrates agronomic, engineering and economic aspects of DI at farm level. Most of the literature reviewed here showed, in general, quite positive effects from DI application, mostly evidenced when the economics of DI is included in the research approach. With regard to the agronomic effects, total fresh mass and total production is generally reduced under DI, whereas the effects on dry matter and product quality are positive, mainly in crops for which excessive soil water availability can cause significant reductions in fruit size, colour or composition (grapes, tomatoes, mangos, etc.. The experimental trial on a lettuce crop in Sicily, during 2005 and 2006, shows that the highest mean marketable yield of lettuce (55.3 t ha-1 in 2005 and 51.9 t ha-1 in 2006 was recorded in plots which received 100% of ET0-PM (reference evapotranspiration by the Penman- Monteith method applied water. In

  10. Faking Attention Deficit Hyperactivity Disorder

    OpenAIRE

    2011-01-01

    Attention-deficit hyperactivity disorder is a common malady in the general population, with up to 8.1 percent of adults meeting criteria for this syndrome. In the college setting, the diagnosis of attention deficit hyperactivity disorder may offer specific academic advantages. Once the diagnosis is assigned, the prescription of stimulant medication may provide additional secondary gains through misuse and/or diversion. For example, these drugs may be used by college consumers to increase aler...

  11. Visuospatial deficits of dyslexic children

    OpenAIRE

    Lipowska, Małgorzata; Czaplewska, Ewa; Wysocka, Anna

    2011-01-01

    Summary Background The visuospatial deficit is recognized as typical for dyslexia only in some definitions. However problems with visuospatial orientation may manifest themselves as difficulties with letter identification or the memorizing and recalling of sign sequences, something frequently experienced by dyslexics. Material/Methods The experimental group consisted of 62 children with developmental dyslexia. The control group consisted of 67 pupils with no diagnosed deficits, matched to the...

  12. Poverty Reduction

    OpenAIRE

    Ortiz, Isabel

    2007-01-01

    The paper reviews poverty trends and measurements, poverty reduction in historical perspective, the poverty-inequality-growth debate, national poverty reduction strategies, criticisms of the agenda and the need for redistribution, international policies for poverty reduction, and ultimately understanding poverty at a global scale. It belongs to a series of backgrounders developed at Joseph Stiglitz's Initiative for Policy Dialogue.

  13. Balancing Acts

    Science.gov (United States)

    ... Past Issues Special Section: Focus on Communication Balancing Acts Past Issues / Fall 2008 Table of Contents For ... scientific research on hearing, balance, smell, taste, voice, speech, and language—common elements in how we perceive ...

  14. Effect of antidepressants on spatial memory deficit induced by dizocilpine.

    Science.gov (United States)

    Tao, Chenjuan; Yan, Weiwei; Li, Yuan; Lu, Xiaodong

    2016-10-30

    Cognitive deficits are a core symptom of schizophrenia. It is controversial whether antidepressants could improve cognitive symptoms in schizophrenia patients. The present study was designed to identify the therapeutic effect of antidepressants on cognitive deficits in schizophrenia. In the present study, adolescent rats were repeatedly exposed to dizocilpine, which can induce cognitive deficits associated with schizophrenia. Then these rats were treated by six antidepressants (fluvoxamine, sertraline, paroxetine, escitalopram, venlafaxine, mirtazapine) or vehicle. The rats in the control group were exposed to vehicle during the study. Lastly, all rats' spatial memory (a major part of cognition) was assessed using the Morris water maze (MWM) test, and the density of hippocampal parvalbumin (PV) interneurons was evaluated to explore possible mechanisms underlying spatial memory change in schizophrenia. The results of the present study supported the hypothesis of a therapeutic effect of fluvoxamine and escitalopram on spatial memory deficit induced by dizocilpine. Additionally, the data of the present study suggested that fluvoxamine and escitalopram remitted hippocampal PV interneuron reduction induced by dizocilpine. The neuroprotective effect of fluvoxamine and escitalopram may partly explain the therapeutic effect of antidepressants on spatial memory deficit in schizophrenia patients.

  15. PRAGMATIC DEFICITS OF ASPERGER SYNDROME

    Directory of Open Access Journals (Sweden)

    Silmy Arizatul Humaira’

    2015-08-01

    Full Text Available Human being is social creature who needs other people to interact with. One of the ways to interact with others is communication with language. However, communication could be a complicated problem for those who were born with developmental disorder called Asperger Syndrome (AS. The communication challenge of Asperger’s is the difficulty using language appropriately for social purposes or known as pragmatic deficits. Many excellent books about autism are published whereas knowledge on pragmatic deficits are still very limited. Thus, it is expected to be a beneficial reference to understand the pragmatic deficits and to create strategies for them to communicate effectively. Therefore, this study aimed at exploring the kinds of pragmatic deficits of an individual with AS. The verbal language profiles of autism purposed by MacDonald (2004 is used to analyzed the data in depth. The descriptive qualitative method is applied to develop a comprehensive understanding about the AS case in Temple Grandin movie.The finding shows that all of the five types of communication deficits are appearing and the dominant of which is unresponsive.

  16. Reduction of turbomachinery noise

    Science.gov (United States)

    Waitz, Ian A. (Inventor); Brookfield, John M. (Inventor); Sell, Julian (Inventor); Hayden, Belva J. (Inventor); Ingard, K. Uno (Inventor)

    1999-01-01

    In the invention, propagating broad band and tonal acoustic components of noise characteristic of interaction of a turbomachine blade wake, produced by a turbomachine blade as the blade rotates, with a turbomachine component downstream of the rotating blade, are reduced. This is accomplished by injection of fluid into the blade wake through a port in the rotor blade. The mass flow rate of the fluid injected into the blade wake is selected to reduce the momentum deficit of the wake to correspondingly increase the time-mean velocity of the wake and decrease the turbulent velocity fluctuations of the wake. With this fluid injection, reduction of both propagating broad band and tonal acoustic components of noise produced by interaction of the blade wake with a turbomachine component downstream of the rotating blade is achieved. In a further noise reduction technique, boundary layer fluid is suctioned into the turbomachine blade through a suction port on the side of the blade that is characterized as the relatively low-pressure blade side. As with the fluid injection technique, the mass flow rate of the fluid suctioned into the blade is here selected to reduce the momentum deficit of the wake to correspondingly increase the time-mean velocity of the wake and decrease the turbulent velocity fluctuations of the wake; reduction of both propagating broad band and tonal acoustic components of noise produced by interaction of the blade wake with a turbomachine component downstream of the rotating blade is achieved with this suction technique. Blowing and suction techniques are also provided in the invention for reducing noise associated with the wake produced by fluid flow around a stationary blade upstream of a rotating turbomachine.

  17. Budget Policy, Deficits, and Defense: A Fiscal Framework for Defense Planning

    Science.gov (United States)

    2005-06-01

    healthcare entitlements―and Reagan’s refusal to increase the largest revenue source―individual income taxes. From GRH to OBRA. Since Reagan and...Emergency Deficit Control Act of 1985 (popularly known as Gramm-Rudman-Hollings [ GRH ] for its Senate sponsors) mandated that the budget be balanced over a...were required to enact spending and tax laws that complied with a specific deficit ceiling.16 If they failed to do so, GRH provided for automatic

  18. Attention Deficits, Attention-Deficit Hyperactivity Disorder, and Intellectual Disabilities

    Science.gov (United States)

    Deutsch, Curtis K.; Dube, William V.; McIlvane, William J.

    2008-01-01

    Attention-Deficit Hyperactivity Disorder (ADHD) and its earlier nosologic classifications have been extensively investigated since the 1960s, with PubMed listings alone exceeding 13,000 entries. Strides have been made in the diagnosis and treatment of ADHD in individuals with intellectual function in the normal range, as described in companion…

  19. Visual Search Deficits Are Independent of Magnocellular Deficits in Dyslexia

    Science.gov (United States)

    Wright, Craig M.; Conlon, Elizabeth G.; Dyck, Murray

    2012-01-01

    The aim of this study was to investigate the theory that visual magnocellular deficits seen in groups with dyslexia are linked to reading via the mechanisms of visual attention. Visual attention was measured with a serial search task and magnocellular function with a coherent motion task. A large group of children with dyslexia (n = 70) had slower…

  20. Grapevine under deficit irrigation: hints from physiological and molecular data.

    Science.gov (United States)

    Chaves, M M; Zarrouk, O; Francisco, R; Costa, J M; Santos, T; Regalado, A P; Rodrigues, M L; Lopes, C M

    2010-05-01

    A large proportion of vineyards are located in regions with seasonal drought (e.g. Mediterranean-type climates) where soil and atmospheric water deficits, together with high temperatures, exert large constraints on yield and quality. The increasing demand for vineyard irrigation requires an improvement in the efficiency of water use. Deficit irrigation has emerged as a potential strategy to allow crops to withstand mild water stress with little or no decreases of yield, and potentially a positive impact on fruit quality. Understanding the physiological and molecular bases of grapevine responses to mild to moderate water deficits is fundamental to optimize deficit irrigation management and identify the most suitable varieties to those conditions. How the whole plant acclimatizes to water scarcity and how short- and long-distance chemical and hydraulic signals intervene are reviewed. Chemical compounds synthesized in drying roots are shown to act as long-distance signals inducing leaf stomatal closure and/or restricting leaf growth. This explains why some plants endure soil drying without significant changes in shoot water status. The control of plant water potential by stomatal aperture via feed-forward mechanisms is associated with 'isohydric' behaviour in contrast to 'anysohydric' behaviour in which lower plant water potentials are attained. This review discusses differences in this respect between grapevines varieties and experimental conditions. Mild water deficits also exert direct and/or indirect (via the light environment around grape clusters) effects on berry development and composition; a higher content of skin-based constituents (e.g. tannins and anthocyanins) has generally being reported. Regulation under water deficit of genes and proteins of the various metabolic pathways responsible for berry composition and therefore wine quality are reviewed.

  1. Widespread auditory deficits in tune deafness.

    Science.gov (United States)

    Jones, Jennifer L; Zalewski, Christopher; Brewer, Carmen; Lucker, Jay; Drayna, Dennis

    2009-02-01

    than the normal control group. Approximately one-third of our participants with tune deafness displayed evidence of attention deficit with hyperactivity disorder on the Test of Variables of Attention. Test of Variables of Attention scores were significantly correlated with gap-detection scores, but not significantly correlated with any of the other experimental measures, including the DTT, DLF, and auditory pattern discrimination tests. Short- and long-term memory was not significantly related to any of the experimental measures. Individuals with tune deafness identified by the DTT have poor performance on many tests of auditory function. These include pure-tone frequency discrimination, pitch and duration pattern discrimination, and temporal resolution. Overall, reduction in performance does not seem to derive from deficits in memory or attention. However, because of the prevalence of attention deficit with hyperactivity disorder in those with tune deafness, this variable should be considered as a potentially confounding factor in future studies of tune deafness and its characteristics. Pure-tone frequency discrimination varied widely in individuals with tune deafness, and the high degree of intertrial variability suggests that frequency discrimination may be unstable in tune-deaf individuals.

  2. Attention Deficit Hyperactivity Disorder (ADHD)

    Centers for Disease Control (CDC) Podcasts

    2014-04-10

    This podcast discusses Attention Deficit Hyperactivity Disorder, or ADHD, the most common behavioral disorder in children. Learn about symptoms, risk factors, and treatment.  Created: 4/10/2014 by National Center on Birth Defects and Developmental Disabilities (NCBDDD).   Date Released: 5/7/2014.

  3. Water supply and tree growth. Part I. Water deficits

    Energy Technology Data Exchange (ETDEWEB)

    Kozlowski, T.T.

    1982-02-01

    Water supply is the most important environmental factor determining distribution, species composition and growth of forests. Net annual primary production of forests varies from as much as 3000 g/m/sub 2/ in wet regions to negligible amounts in dry regions. The water balance of trees has been characterized by visible wilting, tissue moisture content, relative water content, saturation deficit, and water potential. Water deficits develop readily in forest trees, even in trees growing in wet soil, because of excess transpiration over absorption of water. Water deficits adversely affect seed germination and cause shrinkage of leaves, stems, roots, fruits, and cones. Some of the decrease in photosynthesis during drought is the result of increased resistance to diffusion of CO/sub 2/ to chloroplasts and some to decrease in photosynthetic capacity. Water deficits inhibit shoot growth, wood production, and root growth. Yield of fruits and seeds can be inhibited at various stages of reproductive growth such as flower bud initiation, anthesis, pollination, fertilization, embryo growth, and fruit and seed enlargement. Water deficits may also induce leaf scorching and abscission, dieback of twigs and branches, and drought cracks. Severe water deficits often kill trees. Drought tolerance of trees may reflect desiccation avoidance or desiccation tolerance, with the former much more important. Among the most important of these are reduction in number and size of leaves; small, few, and sunken stomata; rapid stomatal closure; abundant leaf waxes; leaf shedding during droughts; extensive root development; capacity for twig and stem photosynthesis; living wood fibers; and strong development of palisade mesophyll.

  4. Adult Attention-Deficit / Hyperactivity Disorder (ADHD)

    Science.gov (United States)

    Adult attention-deficit/hyperactivity disorder (ADHD) Overview Adult attention-deficit/hyperactivity disorder (ADHD) is a mental health disorder that ... combination of persistent problems, such as difficulty paying attention, hyperactivity and impulsive behavior. Adult ADHD can lead ...

  5. Faststats: Attention Deficit Hyperactivity Disorder (ADHD)

    Science.gov (United States)

    ... this? Submit What's this? Submit Button NCHS Home Attention Deficit Hyperactivity Disorder (ADHD)* Recommend on Facebook Tweet ... visits Number of visits to physician offices with attention deficit disorder as the primary diagnosis: 10.9 ...

  6. Collicular dysfunction in attention deficit hyperactivity disorder.

    Science.gov (United States)

    Overton, Paul G

    2008-01-01

    Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder characterised by (inter alia) an increase in distractibility. The current front-line pharmacotherapies for the treatment of ADHD, namely the psychostimulants methylphenidate and amphetamines, have clear abuse potential, hence there is a strong need to develop new drug treatments for this disorder. Central to this process is the identification of the pathophysiological changes which underlie ADHD. Given the heterogeneity of the disorder, multiple loci are probably involved, providing multiple potential therapeutic targets. Here, we hypothesise (Hypothesis 1) that one such locus is the superior colliculus (SC), a sensory structure intimately linked with distractibility and the production of eye and head movements. It is proposed that in ADHD, the colliculus is hyper-responsive, leading to the core symptom of increased distractibility. Hypothesis 1 is supported by: 1. ADHD patients show increased distractibility in tasks which are sensitive to collicular function; 2. ADHD patients have a general problem inhibiting saccades, the generation of which involves the SC; 3. Saccadic deficits in ADHD include defects in the production of saccadic types (anti-saccades and express saccades) which are particularly associated with the colliculus; 4. Covert shifts in attention (which also have been argued to involve the SC) are also impaired in ADHD; 5. Reading disorders are frequently co-morbid with ADHD; dyslexia (which is associated with eye movement problems) is linked to a specific visual perceptual deficit in the M pathway, a major recipient of which is the colliculus. Whether or not the SC is indeed hyper-responsive in ADHD as Hypothesis 1 suggests, the SC may well represent an important therapeutic target for drugs. In fact current psychostimulant therapies, which reduce distractibility, may already work at that level (Hypothesis 2), a contention which is supported by: 1. The

  7. Pragmatic Communication Deficits in Children with Epilepsy

    Science.gov (United States)

    Broeders, Mark; Geurts, Hilde; Jennekens-Schinkel, Aag

    2010-01-01

    Background: Various psychiatric and neurological disorders including epilepsy have been associated with language deficits. Pragmatic language deficits, however, have seldom been the focus of earlier studies in children with epilepsy. Moreover, it is unknown whether these pragmatic deficits are related to general intellectual functioning. Both…

  8. Pragmatic Communication Deficits in Children with Epilepsy

    Science.gov (United States)

    Broeders, Mark; Geurts, Hilde; Jennekens-Schinkel, Aag

    2010-01-01

    Background: Various psychiatric and neurological disorders including epilepsy have been associated with language deficits. Pragmatic language deficits, however, have seldom been the focus of earlier studies in children with epilepsy. Moreover, it is unknown whether these pragmatic deficits are related to general intellectual functioning. Both…

  9. Water-deficit tolerant classification in mutant lines of indica rice

    Directory of Open Access Journals (Sweden)

    Suriyan Cha-um

    2012-04-01

    Full Text Available Water shortage is a major abiotic stress for crop production worldwide, limiting the productivity of crop species, especially in dry-land agricultural areas. This investigation aimed to classify the water-deficit tolerance in mutant rice (Oryza sativa L. spp. indica genotypes during the reproductive stage. Proline content in the flag leaf of mutant lines increased when plants were subjected to water deficit. Relative water content (RWC in the flag leaf of different mutant lines dropped in relation to water deficit stress. A decrease RWC was positively related to chlorophyll a degradation. Chlorophyll a , chlorophyll b , total chlorophyll , total carotenoids , maximum quantum yield of PSII , stomatal conductance , transpiration rate and water use efficiency in mutant lines grown under water deficit conditions declined in comparison to the well-watered, leading to a reduction in net-photosynthetic rate. In addition, when exposed to water deficit, panicle traits, including panicle length and fertile grains were dropped. The biochemical and physiological data were subjected to classify the water deficit tolerance. NSG19 (positive control and DD14 were identified as water deficit tolerant, and AA11, AA12, AA16, BB13, BB16, CC12, CC15, EE12, FF15, FF17, G11 and IR20 (negative control as water deficit sensitive, using Ward's method.

  10. Comparison of duloxetine and methylphenidate in the treatment of children with attention-deficit/hyperactivity disorder

    Directory of Open Access Journals (Sweden)

    Nasrin Dodangi

    2016-06-01

    Full Text Available Background: Attention-deficit/hyperactivity disorder (ADHD is a common and mostly chronic mental health condition that affects children, adolescents, and adults. Stimulants and atomoxetine are first-line agents for the treatment of ADHD. Despite the impressive track record of stimulants in the treatment of ADHD, they fail in 25% of patients due to lack of efficacy or the emergence of unwanted side effects. Accordingly, this study carried out to compare efficacy and safety of duloxetine (a serotonin and norepinephrine reuptake inhibitor and methylphenidate (a short acting stimulant in the treatment of children with attention-deficit/hyperactivity disorder. Methods: Twenty-four children diagnosed with ADHD participated in this 6 weeks open clinical trial. Patients were between 6 to 11 years old that had been referred to psychiatry clinic at Akhavan and Rofide Medical and Rehabilitation Center in Tehran from September 2012 to July 2014. Diagnosis was made by two child psychiatrist according to DSM-IV TR criteria. Thirteen patients received duloxetine and others received methylphenidate. Conner’ parent rating scale-revised-short form (CPRS-RS and ADHD-rating scale (ADHD-RS were used at the beginning and then each two weeks to assess efficacy of treatment. Routine laboratory tests and electrocardiogram (ECG was carried out in the beginning and end of the trial. Results: Twenty children with ADHD completed the study (Ten in methylphenidate and ten in duloxetine group. In both groups, scales of CPRS-RS and ADHD-RS were reduced from baseline to endpoint, but this reduction in methylphenidate group was significantly greater than duloxetine group (P= 0.000. The most common side effect was gastrointestinal problems in duloxetine group and anorexia in methylphenidate group. No serious side effects and no changes in laboratory and ECG indexes were seen in both groups. Conclusion: Duloxetine is not efficacious as well as methylphenidate in treatment of

  11. Motion perception deficit in Down Syndrome.

    Science.gov (United States)

    Del Viva, Maria Michela; Tozzi, Arianna; Bargagna, Stefania; Cioni, Giovanni

    2015-08-01

    It is a well established fact that Down Syndrome (DS) individuals have a tendency to develop Alzheimer's disease (AD) (Lott, I.T., Head, E., 2005. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol. Aging 26, 383-389). They have therefore been proposed as a model to study the pre-dementia stage of Alzheimer's (Mann, D.M., 1988. The pathological association between Down syndrome and Alzheimer disease. Mech. Ageing Dev. 43, 99-136). One of the specific deficits exhibited by AD patients is optic flow motion perception (Tetewsky, S.J., Duffy, C.J., 1999. Visual loss and getting lost in Alzheimer's disease. Neurology 52, 958-965), but there are no corresponding systematic studies in DS individuals. We performed sensitivity measurements to optic flow with Visual Evoked Potentials (VEP) and psychophysical techniques in a group of young DS participants with mild mental retardation and without significant Alzheimer's clinical symptoms. We found a significant reduction in direction discrimination sensitivity to optic flow (random dots moving in radial, rotational and translational trajectories) in DS participants compared to mental age-matched controls, while their sensitivity to direction of control moving stimuli (sinusoidal gratings) was similar to age-matched controls. Measurements of Visual Evoked Potentials (VEP) showed no response to optic flow, although the response to control stimuli (contrast-reversal checkerboard patterns) was significant. Overall, our results show a selective and substantial deficit in the perception of optic flow motion and a corresponding suppression of electroencephalographic activity in DS individuals, thus establishing a further common trait between Down Syndrome and Alzheimer's disease.

  12. Mindfulness and Attention Deficit Hyperactivity Disorder

    Science.gov (United States)

    Smalley, Susan L.; Loo, Sandra K.; Hale, T. Sigi; Shrestha, Anshu; McGough, James; Flook, Lisa; Reise, Steven

    2010-01-01

    Attention Deficit Hyperactivity Disorder (ADHD) is a disorder characterized by attentional difficulties. Mindfulness is a receptive attention to present experience. Both ADHD and mindfulness are associated with attention and personality. This study tests whether individuals with ADHD have lower mindfulness scores than controls and, if true, whether personality contributes to these differences. 105 adults (half with ADHD) were assessed for mindfulness, using the Kentucky Inventory of Mindfulness Skills, and personality, using the Tridimensional Character Inventory. Individuals with ADHD report themselves as less mindful than non-ADHD controls and more novelty-seeking, less self-directed, and more self-transcendent. Mindfulness is negatively associated with ADHD and positively associated with self-directedness and self-transcendence. Analyses of subscales of mindfulness suggest that ADHD is associated most with the ‘Acting in Awareness’ dimension perhaps due to shared items reflecting attentional variability. The current findings support that a large portion of variability in trait mindfulness can be explained by ADHD status and personality traits of self-directedness and self-transcendence. It further suggests that interventions that increase mindfulness might improve symptoms of ADHD and increase self-directedness and/or self-transcendence. PMID:19681107

  13. The nursing student with attention deficit hyperactivity disorder.

    Science.gov (United States)

    Bradshaw, Martha J; Salzer, Judith Schurr

    2003-01-01

    Attention deficit hyperactivity disorder (ADHD) in college-age students presents a complex challenge of coping with academic coursework, refining life skills, and addressing self-limitations. Behaviors that characterize ADHD are particularly problematic for nursing students, especially when the student has difficulty with behaviors that exemplify executive functioning. The authors discuss symptoms and treatments associated with the diagnosis of ADHD and evaluation and interventions for college students, based on guidelines from the Americans With Disabilities Act. Nursing faculty can facilitate academic success by recognizing the problem in nursing students and implementing strategies useful for self-management of ADHD.

  14. Special Education for Children with Attention Deficit Disorder: Current Issues. CRS Report for Congress.

    Science.gov (United States)

    Aleman, Steven R.

    This paper examines issues concerning the eligibility of children with attention deficit disorder (ADD) for special education and related services under the Individuals with Disabilities Education Act (IDEA). A policy memorandum was issued by the Department of Education in September 1991, identifying those circumstances under which such children…

  15. 76 FR 22615 - Privacy Act; Implementation

    Science.gov (United States)

    2011-04-22

    ... the Privacy Act. This will improve the efficiency and effectiveness of DoD's program by preserving the... requirements on the public under the Paperwork Reduction Act of 1995. Section 202, Public Law 104-4, ``Unfunded..., Stat. 1896 (5 U.S.C. 552a). 0 2. In Sec. 322.7, remove and reserve paragraph (l) and add paragraph (u...

  16. The Determinants of Public Deficit Volatility

    OpenAIRE

    2009-01-01

    This paper empirically analyzes the political, institutional and economic sources of public deficit volatility. Using the system-GMM estimator for linear dynamic panel data models and a sample of 125 countries analyzed from 1980 to 2006, we show that higher public deficit volatility is typically associated with higher levels of political instability and less democracy. In addition, public deficit volatility tends to be magnified for small countries, in the outcome of hyper-inflation episodes ...

  17. 77 FR 27787 - Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements

    Science.gov (United States)

    2012-05-11

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Customs Modernization... review and approval in accordance with the Paperwork Reduction Act: Customs Modernization Act Record... techniques or other forms of information. Title: Customs Modernization Act Recordkeeping Requirements....

  18. Adults with attention-deficit/hyperactivity disorder – a brain magnetic resonance spectroscopy study

    Directory of Open Access Journals (Sweden)

    Margaretha eDramsdahl

    2011-11-01

    Full Text Available BackgroundImpaired cognitive control in individuals with Attention-Deficit/Hyperactivity Disorder (ADHD may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the right midfrontal region including the anterior cingulate cortex (ACC in adults with ADHD and healthy controls. MethodsTwenty-nine adults with ADHD and 38 healthy controls were included. We used Proton Magnetic Resonance Imaging with single-voxel point-resolved spectroscopy to measure the ratio of glutamate to creatine (Glu/Cre in the left and the right midfrontal region in the two groups. ResultsThe ADHD group showed a significant reduction of Glu/Cre in the left midfrontal region compared to the controls. ConclusionsThe reduction of Glu/Cre in the left midfrontal region in the ADHD group may reflect a glutamatergic deficit in prefrontal neuronal circuitry in adults with ADHD, resulting in problems with cognitive control.

  19. Adults with attention-deficit/hyperactivity disorder - a brain magnetic resonance spectroscopy study

    DEFF Research Database (Denmark)

    Dramsdahl, Margaretha; Ersland, Lars; Plessen, Kerstin J;

    2011-01-01

    with ADHD and healthy controls. Methods: Twenty-nine adults with ADHD and 38 healthy controls were included. We used Proton Magnetic Resonance Imaging with single voxel point-resolved spectroscopy to measure the ratio of glutamate to creatine (Glu/Cre) in the left and the right midfrontal region in the two...... groups. Results: The ADHD group showed a significant reduction of Glu/Cre in the left midfrontal region compared to the controls. Conclusion: The reduction of Glu/Cre in the left midfrontal region in the ADHD group may reflect a glutamatergic deficit in prefrontal neuronal circuitry in adults with ADHD......Background: Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the right midfrontal region including the anterior cingulate cortex in adults...

  20. A Multiple Deficit Model of Reading Disability and Attention-Deficit/Hyperactivity Disorder: Searching for Shared Cognitive Deficits

    Science.gov (United States)

    McGrath, Lauren M.; Pennington, Bruce F.; Shanahan, Michelle A.; Santerre-Lemmon, Laura E.; Barnard, Holly D.; Willcutt, Erik G.; DeFries, John C.; Olson, Richard K.

    2011-01-01

    Background: This study tests a multiple cognitive deficit model of reading disability (RD), attention-deficit/hyperactivity disorder (ADHD), and their comorbidity. Methods: A structural equation model (SEM) of multiple cognitive risk factors and symptom outcome variables was constructed. The model included phonological awareness as a unique…

  1. Attentional deficits in patients with persisting postconcussive complaints: a general deficit or specific component deficit?

    Science.gov (United States)

    Chan, Raymond C K

    2002-12-01

    This study aimed to examine attentional performance in patients with persisting postconcussive complaints, using a multi-componential perspective. Comparisons of attentional performances of 92 patients with postconcussive complaints and 86 normal controls were conducted using tests of sustained attention (Sustained Attention to Response Task; Digit Backward Span), selective attention (Stroop Word-Color Test; Color Trails Test), divided attention (Paced Auditory Serial Addition Test; Symbol Digit Modalities Test), and attentional control processing (Six Elements Test; Tower of Hanoi). Questionnaires on daily life inattentive behaviour were also administered to all participants and their significant others. A MANOVA indicated that patients with persisting postconcussive complaints demonstrated a general deficit in attentional performance as compared with their normal controls, F(18, 145) = 7.939, p = .005. These patterns still persisted when measures of emotional disturbance were controlled, F(18, 143) = 5.159, p = .005. Moreover, for sustained attention and selective attention, we were able to statistically control for speed and the differences remained. Future research should be conducted to better control the potential confound of speed for all the attentional components in order to differentiate any specific component deficits in these patients.

  2. Timing deficits in attention-deficit/hyperactivity disorder (ADHD) : Evidence from neurocognitive and neuroimaging studies

    NARCIS (Netherlands)

    Noreika, Valdas; Falter, Christine M.; Rubia, Katya

    Relatively recently, neurocognitive and neuroimaging studies have indicated that individuals with attention-deficit/hyperactivity disorder (ADHD) may have deficits in a range of timing functions and their underlying neural networks. Despite this evidence, timing deficits in ADHD are still somewhat

  3. Timing deficits in attention-deficit/hyperactivity disorder (ADHD) : Evidence from neurocognitive and neuroimaging studies

    NARCIS (Netherlands)

    Noreika, Valdas; Falter, Christine M.; Rubia, Katya

    2013-01-01

    Relatively recently, neurocognitive and neuroimaging studies have indicated that individuals with attention-deficit/hyperactivity disorder (ADHD) may have deficits in a range of timing functions and their underlying neural networks. Despite this evidence, timing deficits in ADHD are still somewhat n

  4. Poor Reading: A Deficit in Skill-Automatization or a Phonological Deficit?

    Science.gov (United States)

    Wimmer, Heinz; Mayringer, Heinz; Landerl, Karin.

    1998-01-01

    Examines whether the characteristic reading speed impairment of German dyslexic children resulted from a general skill-automatization deficit or a phonological deficit. Tests a dyslexic and nondyslexic group of boys in grade 2. Concludes that difficulties in learning to read are due phonological deficit and not a general skill-automatization…

  5. Current account deficit sustainability in selected transition economies

    Directory of Open Access Journals (Sweden)

    Aleksander Aristovnik

    2006-05-01

    Full Text Available The article examines the question of whether the current account deficits seen inselected transition economies in recent years mainly as a symptom of the dynamiceconomic activity of the catching-up process are a source of potentialmacroeconomic destabilisation. Given the possible significant reduction of capitalflows, as well as restrictions and lessons from recent financial crises, currentaccount deficits must be closely monitored in the region. In this respect, the issue of‘current account sustainability’ in seventeen transition economies is investigated.For this purpose, two accounting frameworks (Milesi-Ferreti and Razin, 1996;Reisen, 1998 based on certain strict assumptions are employed. The results showthat if the observed level of foreign direct investment (FDI flows is kept in themedium run almost all countries could optimally have a higher level of externaldeficit, with the exception of countries such as Baltic States, Hungary, Macedonia,Moldova and Romania. Accordingly, the maintenance of relatively large FDIinflows (especially greenfield investments to national economies is a key priority insecuring future external sustainability. In the end, the results indicate that currentaccount deficits of transition economies that exceed 5 percent of GDP generallyinvolve problems of their external sustainability

  6. Response mechanisms of Brachiaria brizantha cultivars to water deficit stress

    Directory of Open Access Journals (Sweden)

    Patricia Menezes Santos

    2013-11-01

    Full Text Available Two cultivars of Brachiaria brizantha (Hochst ex. A. Rich Stapf. (Syn. Urochloa were evaluated for their adaptation to water deficit and the stress response mechanisms in a greenhouse experiment. The experimental design was in completely randomized blocks with a 2 × 2 × 4 factorial arrangement. The Marandu and BRS Piatã cultivars were evaluated under two water availability conditions, with or without water restriction. The harvests were carried out 0, 7, 14 and 28 days after the start of water restriction. For both cultivars, the water deficit stress caused a reduction in shoot biomass and leaf area and an increase in the percentage of roots in the deeper soil layers. The B. brizantha cv. Marandu reached critical levels of leaf water potential in a shorter period of water restriction than did the B. brizantha cv. BRS Piatã. The osmoregulation and deepening of the root system are mechanisms of adaptation to water stress observed in both Marandu and BRS Piatã cultivars. Besides that, the Marandu cultivar also increases its leaf senescence and, consequentially, decreases its leaf area, as a response to water deficit.

  7. Cognitive Deficits in the Pathogenesis of Autism.

    Science.gov (United States)

    Rutter, M.

    1983-01-01

    Reports empirical findings indicating that autistic children have a basic cognitive deficit that is not a secondary consequence of social withdrawal. The precise nature of the deficit is discussed, as are studies of autistic children's general intelligence, language abnormalities, and social impairments. (RH)

  8. Kognitive deficit ved skizofreni og andre psykoser

    DEFF Research Database (Denmark)

    Fagerlund, Birgitte; Glenthøj, Birte Y

    2008-01-01

    and there is considerable incentive to develop treatments that can improve these deficits. The current brief review summarizes the relevance of cognitive deficits for the pathogenesis and prognosis of psychotic disorders, and identifies pertinent issues within the research field Udgivelsesdato: 2008/11/10...

  9. SCADA Application for ACTS Technology

    Science.gov (United States)

    Fairbanks, Barry

    1992-01-01

    The results of a system level study done by Hughes Network Systems for NASA are presented. For the supervisory control and data acquisition (SCADA) application, use of Ka-band spot beam satellite technology associated with NASA's Advanced Communication Technology Satellite (ACTS) offers a reduction in Earth station antenna size and transmitter power that may translate into lower system costs. The approaches taken to determine commercial potential of the system are described.

  10. Sensory gating deficits and impaired quality of life in patients with schizophrenia: A preliminary study.

    Science.gov (United States)

    Micoulaud-Franchi, Jean-Arthur; Faugere, Mélanie; Boyer, Laurent; Cermolacce, Michel; Fond, Guillaume; Richieri, Raphaëlle; Vion-Dury, Jean; Lancon, Christophe

    2016-09-01

    New determinants of quality of life in schizophrenia need to be identified. As sensory gating deficit is core impairment in schizophrenia, the present study hypothesized that sensory gating deficit is a determinant of impaired quality of life in schizophrenia. This study therefore investigated the relationship between sensory gating deficit and quality of life in patients with schizophrenia after adjusting for key confounding factors. Sensory gating was assessed with the auditory event-related potential method by measuring P50 amplitude changes in a double-click conditioning-testing procedure, perceptual impairments related to sensory gating deficit was assessed with the SGI questionnaire and quality of life was assessed with the SQoL 18 questionnaire in 39 patients with schizophrenia. Patients with sensory gating deficit (n=14) had a lower subjective quality of life on the psychological well-being dimension evaluated with SQoL 18 questionnaire (p=0.008) compared to those without it (n=25). This result remained significant (B=-0.45, Wald=4.84, p=0.02) after taking into account 7 potential confounding factors (gender, age, level of education, duration of disorder, positive symptoms, depressive symptoms and anxiety symptoms). Poorer psychological well-being was related to a higher score on the SGI (rho=-0.40, p=0.01), in particular on the Distractibility dimension (rho=-0.47, p=0.001). These findings suggest that sensory gating deficit may be a determinant of impaired quality of life in schizophrenia. Further studies are needed to address the causal relationship between sensory gating deficit, perceptual impairments, attentional deficit and impaired quality of life in schizophrenia in order to act more efficiently on the quality of life of patients with this disorder.

  11. THE IMPLICATIONS OF GROSS FIXED CAPITAL AND UNEMPLOYMENT RATE ON GENERAL GOVERNMENT DEFICIT. EMPIRICAL STUDY AT THE EUROPEAN LEVEL

    OpenAIRE

    2010-01-01

    In this paper we have evaluated the influence of the modification of public investment level and unemployment rate on the general government deficit at the European Union level. We have created a regression model that shows that a sustained and increased investment policy and the reduction of unemployment rate have a favorable effect on the objective of minimizing the budget deficit. In the last years European Union’s countries had to face a difficult problem concerning fiscal policy. They ha...

  12. THE IMPLICATIONS OF GROSS FIXED CAPITAL AND UNEMPLOYMENT RATE GENERAL GOVERNMENT DEFICIT. EMPIRICAL STUDY AT THE EUROPEAN LEVEL

    OpenAIRE

    2010-01-01

    In this paper we evaluate the influence of the modification of public investment level and unemployment rate on the general government deficit at the European Union level. We create a regression model that shows that a sustained and increased investment policy and the reduction of unemployment rate have a favorable effect on the objective of minimizing the budget deficit. In the last years European Union’s countries had to face a difficult problem concerning fiscal policy. They have to make p...

  13. Pramipexole reverses Parkinson's disease-related motivational deficits in rats.

    Science.gov (United States)

    Favier, Mathieu; Duran, Theo; Carcenac, Carole; Drui, Guillaume; Savasta, Marc; Carnicella, Sebastien

    2014-06-01

    Recent evidence suggests that Parkinson's disease affects not only movement, but also cognitive and psychiatric functions. Among these nonmotor complications, apathy, which is defined as a lack of motivation and operationalized as a quantitative reduction in goal-directed behavior, may even precede motor impairments, disappearing with the introduction of dopaminergic (DA) therapies and possibly reappearing with its discontinuation, suggesting a causal role of DA. We recently developed a lesion-based model, with stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into precise areas of the rat SNc or ventral tegmental area and showed, in several operant tasks, that a partial denervation of the nigrostriatal, but not of the mesocorticolimbic, DA system induced profound motivational deficits during instrumental action. We investigated the time course of the effects of nigrostriatal DA denervation on motivation in rats, by assessing the negative effect of SNc bilateral 6-OHDA infusion on preacquired operant behavior, and determining whether the induced deficits were sensitive to the introduction and withdrawal of a clinically relevant PD treatment, the DA D2/D3 receptor agonist, pramipexole (PRA). Partial nigrostriatal DA denervation was accompanied by a significant reduction in operant behavior. This deficit, indicative of a decrease in motivation, was fully reversed by PRA and reappeared after treatment withdrawal. This longitudinal preclinical study provides evidence for the implication of the DA nigrostriatal system in PD-associated apathy. Moreover, by showing a good isomorphy and predictive value, our model highlights the relevance of D2/D3 receptors as potential targets for alleviating apathy in PD.

  14. Simultaneous object perception deficits are related to reduced visual processing speed in amnestic mild cognitive impairment.

    Science.gov (United States)

    Ruiz-Rizzo, Adriana L; Bublak, Peter; Redel, Petra; Grimmer, Timo; Müller, Hermann J; Sorg, Christian; Finke, Kathrin

    2017-07-01

    Simultanagnosia, an impairment in simultaneous object perception, has been attributed to deficits in visual attention and, specifically, to processing speed. Increasing visual attention deficits manifest over the course of Alzheimer's disease (AD), where the first changes are present already in its symptomatic predementia phase: amnestic mild cognitive impairment (aMCI). In this study, we examined whether patients with aMCI due to AD show simultaneous object perception deficits and whether and how these deficits relate to visual attention. Sixteen AD patients with aMCI and 16 age-, gender-, and education-matched healthy controls were assessed with a simultaneous perception task, with shapes presented in an adjacent, embedded, or overlapping manner, under free viewing without temporal constraints. We used a parametric assessment of visual attention based on the Theory of Visual Attention. Results show that patients make significantly more errors than controls when identifying overlapping shapes, which correlate with reduced processing speed. Our findings suggest simultaneous object perception deficits in very early AD, and a visual processing speed reduction underlying these deficits. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Exceptional Reductions

    CERN Document Server

    Marrani, Alessio; Riccioni, Fabio

    2011-01-01

    Starting from basic identities of the group E8, we perform progressive reductions, namely decompositions with respect to the maximal and symmetric embeddings of E7xSU(2) and then of E6xU(1). This procedure provides a systematic approach to the basic identities involving invariant primitive tensor structures of various irreprs. of finite-dimensional exceptional Lie groups. We derive novel identities for E7 and E6, highlighting the E8 origin of some well known ones. In order to elucidate the connections of this formalism to four-dimensional Maxwell-Einstein supergravity theories based on symmetric scalar manifolds (and related to irreducible Euclidean Jordan algebras, the unique exception being the triality-symmetric N = 2 stu model), we then derive a fundamental identity involving the unique rank-4 symmetric invariant tensor of the 0-brane charge symplectic irrepr. of U-duality groups, with potential applications in the quantization of the charge orbits of supergravity theories, as well as in the study of mult...

  16. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.

    Science.gov (United States)

    Izzo, Nicholas J; Staniszewski, Agnes; To, Lillian; Fa, Mauro; Teich, Andrew F; Saeed, Faisal; Wostein, Harrison; Walko, Thomas; Vaswani, Anisha; Wardius, Meghan; Syed, Zanobia; Ravenscroft, Jessica; Mozzoni, Kelsie; Silky, Colleen; Rehak, Courtney; Yurko, Raymond; Finn, Patricia; Look, Gary; Rishton, Gilbert; Safferstein, Hank; Miller, Miles; Johanson, Conrad; Stopa, Edward; Windisch, Manfred; Hutter-Paier, Birgit; Shamloo, Mehrdad; Arancio, Ottavio; LeVine, Harry; Catalano, Susan M

    2014-01-01

    Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD). Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface receptor expression that is the basis for inhibition of electrophysiological measures of synaptic plasticity and thus learning and memory. We have utilized phenotypic screens in mature, in vitro cultures of rat brain cells to identify small molecules which block or prevent the binding and effects of Abeta oligomers. Synthetic Abeta oligomers bind saturably to a single site on neuronal synapses and induce deficits in membrane trafficking in neuronal cultures with an EC50 that corresponds to its binding affinity. The therapeutic lead compounds we have found are pharmacological antagonists of Abeta oligomers, reducing the binding of Abeta oligomers to neurons in vitro, preventing spine loss in neurons and preventing and treating oligomer-induced deficits in membrane trafficking. These molecules are highly brain penetrant and prevent and restore cognitive deficits in mouse models of Alzheimer's disease. Counter-screening these compounds against a broad panel of potential CNS targets revealed they are highly potent and specific ligands of the sigma-2/PGRMC1 receptor. Brain concentrations of the compounds corresponding to greater than 80% receptor occupancy at the sigma-2/PGRMC1 receptor restore cognitive function in transgenic hAPP Swe/Ldn mice. These studies demonstrate that synthetic and human-derived Abeta oligomers act as pharmacologically-behaved ligands at neuronal receptors--i.e. they exhibit saturable binding to a target, they exert a functional effect related to their binding and their displacement by small molecule antagonists blocks their functional effect. The first-in-class small molecule receptor antagonists described here restore memory to normal in multiple AD models

  17. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.

    Directory of Open Access Journals (Sweden)

    Nicholas J Izzo

    Full Text Available Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta 1-42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD. Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface receptor expression that is the basis for inhibition of electrophysiological measures of synaptic plasticity and thus learning and memory. We have utilized phenotypic screens in mature, in vitro cultures of rat brain cells to identify small molecules which block or prevent the binding and effects of Abeta oligomers. Synthetic Abeta oligomers bind saturably to a single site on neuronal synapses and induce deficits in membrane trafficking in neuronal cultures with an EC50 that corresponds to its binding affinity. The therapeutic lead compounds we have found are pharmacological antagonists of Abeta oligomers, reducing the binding of Abeta oligomers to neurons in vitro, preventing spine loss in neurons and preventing and treating oligomer-induced deficits in membrane trafficking. These molecules are highly brain penetrant and prevent and restore cognitive deficits in mouse models of Alzheimer's disease. Counter-screening these compounds against a broad panel of potential CNS targets revealed they are highly potent and specific ligands of the sigma-2/PGRMC1 receptor. Brain concentrations of the compounds corresponding to greater than 80% receptor occupancy at the sigma-2/PGRMC1 receptor restore cognitive function in transgenic hAPP Swe/Ldn mice. These studies demonstrate that synthetic and human-derived Abeta oligomers act as pharmacologically-behaved ligands at neuronal receptors--i.e. they exhibit saturable binding to a target, they exert a functional effect related to their binding and their displacement by small molecule antagonists blocks their functional effect. The first-in-class small molecule receptor antagonists described here restore memory to normal in

  18. Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

    Science.gov (United States)

    Izzo, Nicholas J.; Staniszewski, Agnes; To, Lillian; Fa, Mauro; Teich, Andrew F.; Saeed, Faisal; Wostein, Harrison; Walko, Thomas; Vaswani, Anisha; Wardius, Meghan; Syed, Zanobia; Ravenscroft, Jessica; Mozzoni, Kelsie; Silky, Colleen; Rehak, Courtney; Yurko, Raymond; Finn, Patricia; Look, Gary; Rishton, Gilbert; Safferstein, Hank; Miller, Miles; Johanson, Conrad; Stopa, Edward; Windisch, Manfred; Hutter-Paier, Birgit; Shamloo, Mehrdad; Arancio, Ottavio; LeVine, Harry; Catalano, Susan M.

    2014-01-01

    Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1–42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD). Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface receptor expression that is the basis for inhibition of electrophysiological measures of synaptic plasticity and thus learning and memory. We have utilized phenotypic screens in mature, in vitro cultures of rat brain cells to identify small molecules which block or prevent the binding and effects of Abeta oligomers. Synthetic Abeta oligomers bind saturably to a single site on neuronal synapses and induce deficits in membrane trafficking in neuronal cultures with an EC50 that corresponds to its binding affinity. The therapeutic lead compounds we have found are pharmacological antagonists of Abeta oligomers, reducing the binding of Abeta oligomers to neurons in vitro, preventing spine loss in neurons and preventing and treating oligomer-induced deficits in membrane trafficking. These molecules are highly brain penetrant and prevent and restore cognitive deficits in mouse models of Alzheimer's disease. Counter-screening these compounds against a broad panel of potential CNS targets revealed they are highly potent and specific ligands of the sigma-2/PGRMC1 receptor. Brain concentrations of the compounds corresponding to greater than 80% receptor occupancy at the sigma-2/PGRMC1 receptor restore cognitive function in transgenic hAPP Swe/Ldn mice. These studies demonstrate that synthetic and human-derived Abeta oligomers act as pharmacologically-behaved ligands at neuronal receptors - i.e. they exhibit saturable binding to a target, they exert a functional effect related to their binding and their displacement by small molecule antagonists blocks their functional effect. The first-in-class small molecule receptor antagonists described here restore memory to normal in multiple AD

  19. Postural control deficits identify lingering post-concussion neurological deficits

    Institute of Scientific and Technical Information of China (English)

    Thomas A. Buckley; Jessie R. Oldham; Jaclyn B. Caccese

    2016-01-01

    Concussion, or mild traumatic brain injury, incidence rates have reached epidemic levels and impaired postural control is a cardinal symptom. The purpose of this review is to provide an overview of the linear and non-linear assessments of post-concussion postural control. The current acute evaluation for concussion utilizes the subjective balance error scoring system (BESS) to assess postural control. While the sensitivity of the overall test battery is high, the sensitivity of the BESS is unacceptably low and, with repeat administration, is unable to accurately identify recovery. Sophisticated measures of postural control, utilizing traditional linear assessments, have identified impairments in postural control well beyond BESS recovery. Both assessments of quiet stance and gait have identified lingering impairments for at least 1 month post-concussion. Recently, the application of non-linear metrics to concussion recovery have begun to receive limited attention with the most commonly utilized metric being approximate entropy (ApEn). ApEn, most commonly in the medial-lateral plane, has successfully identified impaired postural control in the acute post-concussion timeframe even when linear assessments of instrumented measures are equivalent to healthy pre-injury values;unfortunately these studies have not gone beyond the acute phase of recovery. One study has identified lingering deficits in postural control, utilizing Shannon and Renyi entropy metrics, which persist at least through clinical recovery and return to participation. Finally, limited evidence from two studies suggest that individuals with a previous history of a single concussion, even months or years prior, may display altered ApEn metrics. Overall, non-linear metrics provide a fertile area for future study to further the understanding of postural control impairments acutely post-concussion and address the current challenge of sensitive identification of recovery.

  20. Ondansetron reduces lasting vestibular deficits in a model of severe peripheral excitotoxic injury.

    Science.gov (United States)

    Dyhrfjeld-Johnsen, Jonas; Gaboyard-Niay, Sophie; Broussy, Audrey; Saleur, Aurélie; Brugeaud, Aurore; Chabbert, Christian

    2013-01-01

    Vestibular neuritis is a neuroinflammatory, peripheral vestibular pathology leading to chronic deficits and long-term disability. While current corticosteroid-based therapy does not appear to positively influence the long term outcome for the patient, a recent clinical pilot study suggested a functional vestibuloprotective effect of the anti-emetic ondansetron in the treatment of vestibular neuritis. We here demonstrate that systemic post-insult administration of ondansetron in a novel rat model of severe excitotoxic vestibular insult reproduces the clinically demonstrated functional benefits. This ondansetron-conferred reduction of functional deficits stems from the protection of synapses between sensory hair cells and primary neurons from excitotoxically induced lesion.

  1. In science communication, why does the idea of a public deficit always return? How do the shifting information flows in healthcare affect the deficit model of science communication?

    Science.gov (United States)

    Ko, Henry

    2016-05-01

    The healthcare field contains a multitude of opportunities for science communication. Given the many stakeholders dancing together in a multidirectional tango of communication, we need to ask how much does the deficit model apply to the health field? History dictates that healthcare professionals are the holders of all knowledge, and the patients and other stakeholders are the ones that need the scientific information communicated to them. This essay argues otherwise, in part due to the rise of shared decision-making and patients and other stakeholders acting as partners in healthcare. The traditional deficit model in health held that: (1) doctors were experts and patients were consumers, (2) it is impossible for the public to grasp the many disciplines of knowledge in medicine, (3) if experts have trouble keeping up with medical research then the public surely can't keep up, and (4) it is safer for healthcare professionals to communicate to the public using a deficit model. However, with the rise of partnerships with patients in healthcare decision-making, the deficit model might be weakening. Examples of public participation in healthcare decision-making include: (1) crowd-sourcing public participation in systematic reviews, (2) public participation in health policy, (3) public collaboration in health research, and (4) health consumer groups acting as producers of health information. With the challenges to the deficit model in science communication in health, caution is needed with the increasing role of technology and social media, and how these may affect the legitimacy of healthcare information flows away from the healthcare professional.

  2. DETERMINANTS OF CURRENT ACCOUNT DEFICIT AND ECONOMY POLICIES PRACTICES FOR CURRENT ACCOUNT DEFICIT IN TURKISH ECONOMY

    Directory of Open Access Journals (Sweden)

    Veysel Karagol

    2017-03-01

    Full Text Available In last years with the impact of rapid globalization and financiallisation current account deficit became a major problem for Turkish economy. Hence, many studies have been conducted foreseeing for policy recommendations and precautions against the current deficit. In this study, by considering determinants of current account deficit and implemented policies, it is intended to provide policy recommendations for closing the deficit. As part of this goal, the determinants of current account deficit and impacts of the determinantsa re discussed. Also, by mentioning monetary and fiscal policies during the period 2003-2015 overall assessment of the policies and a set of policiy recommendations for the next periods were presented. The most important result achieved by the study is applying discussed structural reforms in able to have quick progress in dealing with the current account deficit would have a great effect.

  3. Neuropsychological deficits associated with uraemic encephalopathy

    African Journals Online (AJOL)

    (ESRD) often present with impaired cognitive functions, little information exists concerning ... during conditions of time-pressure); (i/) deficit in attentional processes .... behaviour is functional or psychoneurological in origin), which could have ...

  4. Did goethe describe attention deficit hyperactivity disorder?

    Science.gov (United States)

    Bonazza, Sara; Scaglione, Cesa; Poppi, Massimo; Rizzo, Giovanni

    2011-01-01

    As early as 1846, the typical symptoms of attention deficit hyperactivity disorder (ADHD) were described by Heinrich Hoffmann (1809-1894). However, in Goethe's masterpiece Faust (1832), the character of Euphorion strongly suggests ADHD diagnosis.

  5. Attention Deficit Hyperactivity Disorder Intervention: Strategies ...

    African Journals Online (AJOL)

    Attention Deficit Hyperactivity Disorder Intervention: Strategies & Counselling Tips for Primary School Teachers. ... to equip them to enable them give care and support to ADHD pupils in the learning process and make referral when necessary.

  6. Deficits and Growth from Romania's Perspective

    Directory of Open Access Journals (Sweden)

    Bogdan Andrei MOLDOVAN

    2009-06-01

    Full Text Available In the last eight years Romania has encountereda significant growth of the GDP. However,the economy does not seem capable to value thisgrowth by balancing the budget and reducing thecurrent account deficit, problems that are persistentduring the last period.In 2008 the Romanian economy had thehighest level of budget deficit since the 90’s. Thereis an important debate between the economistson this issue and we have to see if there is anyreason to worry, having in mind the current globalfinancial crisis.This paper tries to analyze the problemsof budgetary deficit, current account deficit andeconomic growth. We will take a look on last periodstatistics and on specific literature, see how thosevariables evolved over time and in different casesand we will try to identify possible connectionsbetween them.

  7. Dissociations between developmental dyslexias and attention deficits

    OpenAIRE

    Limor eLukov; Naama eFriedmann; Lilach eShalev; Lilach eKhentov-Kraus; Nir eShalev; Rakefet eLorber; Revital eGuggenheim

    2015-01-01

    We examine whether attention deficits underlie developmental dyslexia, or certain types of dyslexia, by presenting double dissociations between the two. We took into account the existence of distinct types of dyslexia and of attention deficits, and focused on dyslexias that may be thought to have an attentional basis: letter position dyslexia (LPD), in which letters migrate within words, attentional dyslexia (AD), in which letters migrate between words, neglect dyslexia, in which letters on o...

  8. Attention deficit in children: a multiprofessional approach

    OpenAIRE

    2015-01-01

    Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavior disorder in children characterized by attention deficit, overactivity and impulsivity, which may persist into adolescence and adulthood. It is often complicated with multiple comorbid disorders which when undiagnosed or untreated significantly affects the children on aspects like academic skills, peer relationship, social life and difficulty in leading productive lives. This report presents a case of 12 year old male ...

  9. Neuropsychological deficits in patients with Lyme borreliosis

    OpenAIRE

    Katja Pruša

    2001-01-01

    Slovenia is an endemic area for Lyme borreliosis, a disease that affects many organic systems. Decline in cognitive abilities and emotional changes can appear in acute and chronic stage of the disease beside somatic difficulties. Early antibiotic therapy is of great importance in recovery. Attention and concentration deficits, memory deficits, impaired executive functioning, depression and other symptoms reduce work efficiency and life quality of people with Lyme borreliosis. Neuropsychologic...

  10. Orbitofrontal cortex abnormality and deficit schizophrenia.

    Science.gov (United States)

    Kanahara, Nobuhisa; Sekine, Yoshimoto; Haraguchi, Tadashi; Uchida, Yoshitaka; Hashimoto, Kenji; Shimizu, Eiji; Iyo, Masaomi

    2013-02-01

    Deficit syndrome, which is characterized by primary and enduring negative symptoms, is a homogeneous subtype within schizophrenia. Negative symptoms in schizophrenia are currently considered to be closely linked with frontal lobe impairment. However, the etiology in the frontal lobe of people with deficit syndrome is not fully understood. We measured regional cerebral blood flow (rCBF) with single photon emission computed tomography (SPECT) in 33 patients with deficit syndrome, 40 patients with nondeficit syndrome, and 45 healthy controls, and we compared groups using the voxel-wise method. Schizophrenia combined group, the deficit syndrome and the nondeficit syndrome presented hypoperfusion in mainly the medial and lateral prefrontal cortices. The deficit syndrome group showed a significant decrease in rCBF in the right orbitofrontal cortex (OFC) compared to the nondeficit group. These results demonstrated that at-rest hypofrontality was a common feature within the disease group and suggested that the OFC might play an important role in the development of severe negative symptoms in people with deficit syndrome.

  11. Effect of Wind Intermittency on the Electric Grid: Mitigating the Risk of Energy Deficits

    CERN Document Server

    George, Sam O; Nguyen, Scott V

    2010-01-01

    Successful implementation of California's Renewable Portfolio Standard (RPS) mandating 33 percent renewable energy generation by 2020 requires inclusion of a robust strategy to mitigate increased risk of energy deficits (blackouts) due to short time-scale (sub 1 hour) intermittencies in renewable energy sources. Of these RPS sources, wind energy has the fastest growth rate--over 25% year-over-year. If these growth trends continue, wind energy could make up 15 percent of California's energy portfolio by 2016 (wRPS15). However, the hour-to-hour variations in wind energy (speed) will create large hourly energy deficits that require installation of other, more predictable, compensation generation capacity and infrastructure. Compensating for the energy deficits of wRPS15 could potentially cost tens of billions in additional dollar-expenditure for fossil and / or nuclear generation capacity. There is a real possibility that carbon dioxide and other greenhouse gas (GHG) emission reductions will miss the California ...

  12. Mental health, belief deficit compensation, and paranormal beliefs.

    Science.gov (United States)

    Schumaker, J F

    1987-09-01

    The present study examined the relationship between religious and nonreligious paranormal beliefs and mental health, as well as the possibility that nonreligious subjects compensate for a lack of identification with traditional religion by increased nonreligious paranormal beliefs. Subjects were 80 undergraduates categorized as religious or nonreligious on the basis of scores on the Traditional Religion subscale of the Paranormal Belief Scale. Religious subjects had significantly higher total paranormal belief scores than nonreligious subjects. Those adopting religious paranormal beliefs were actually somewhat more likely to adopt other nonreligious paranormal beliefs. The failure of nonreligious subjects to compensate fully for this traditional religious belief deficit was reflected in their mental health ratings on the Langer's Mental Health Scale (Langer, 1962). Paranormal beliefs were found to be negatively correlated with reported symptoms of psychopathology, supporting the formulation that paranormal beliefs may serve to ensure psychic integrity by acting as "self-serving cognitive biases."

  13. Executive functioning in boys with ADHD: primarily an inhibition deficit?

    NARCIS (Netherlands)

    Scheres, A.P.J.; Oosterlaan, J.; Geurts, H.M.; Morein-Zamir, S.; Meiran, N.; Vlasveld, L.; Sergeant, J.A.

    2004-01-01

    This study was aimed at: (1) testing whether boys with Attention Deficit/Hyperactivity Disorder (ADHD) demonstrate a deficit in response inhibition and deficits in other executive functions (EF), or alternatively, demonstrate a deficit in only response inhibition; (2) investigating which role associ

  14. A Comparison of Behavioral Parent Training Programs for Fathers of Children with Attention-Deficit/Hyperactivity Disorder

    Science.gov (United States)

    Fabiano, Gregory A.; Chacko, Anil; Pelham, William E., Jr.; Robb, Jessica; Walker, Kathryn S.; Wymbs, Frances; Sastry, Amber L.; Flammer, Lizette; Keenan, Jenna K.; Visweswaraiah, Hema; Shulman, Simon; Herbst, Laura; Pirvics, Lauma

    2009-01-01

    Few behavioral parent training (BPT) treatment studies for attention-deficit/hyperactivity disorder (ADHD) have included and measured outcomes with fathers. In this study, fathers were randomly assigned to attend a standard BPT program or the Coaching Our Acting-Out Children: Heightening Essential Skills (COACHES) program. The COACHES program…

  15. Effect of OROS methylphenidate on encopresis in children with attention-deficit/hyperactivity disorder.

    Science.gov (United States)

    Yılmaz, Savaş; Bilgiç, Ayhan; Hergüner, Sabri

    2014-04-01

    Although encopresis shows a high rate of comorbidity in patients with attention-deficit/hyperactivity disorder (ADHD), the etiologic origin of this relationship and the effect of ADHD drugs on encopresis are unclear. In this chart review, we explored the effect of OROS long-acting methylphenidate (MPH) treatment on encopresis in children with ADHD. We also evaluated the relationship between the clinical variables of ADHD and encopresis. The sample consisted of 21 children and adolescents (20 boys and 1 girl) with encopresis and coexisting ADHD 7-15 years of age. Their clinical characteristics and baseline (visit 1) and end of the second months' (visit 2) Conners' Parent Rating Scale (CPRS) subscores were recorded. Retrospective clinician determinations were made using the Clinical Global Impressions-Severity subscale (CGI-S) for encopresis severity and the Clinical Global Impressions-Improvement subscale (CGI-I) for encopresis response. According to the CGI-I, 14 subjects (71.4 %) showed much or very much improvement in their encopresis at the second visit. All of the CPRS scores showed a significant reduction during the second visit. No association was found between the CGI-I score and the changes in any of the CPRS scores. Baseline oppositional defiant disorder (ODD) and conduct disorder (CD) scores were correlated with the CGI-S score; however, no association was found between core ADHD symptom severity and the CGI-S score. With regard to the encopresis outcome, the baseline CD score was negatively correlated with the CGI-I score, and the baseline ODD score was prone to show a negative correlation with the CGI-I score. These results suggest that coexisting behavioral problems may be a vulnerability factor based on the severity of encopresis, and that MPH treatment may have a positive effect on encopresis in children and adolescents with ADHD.

  16. Acute oral Bryostatin-1 administration improves learning deficits in the APP/PS1 transgenic mouse model of Alzheimer's disease.

    Science.gov (United States)

    Schrott, L M; Jackson, K; Yi, P; Dietz, F; Johnson, G S; Basting, T F; Purdum, G; Tyler, T; Rios, J D; Castor, T P; Alexander, J S

    2015-01-01

    Previous studies showed that Bryostatin-1, a potent PKC modulator and alphasecretase activator, can improve cognition in models of Alzheimer's disease (AD) with chronic (>10 weeks), intraperitoneal (i.p.) administration of the drug. We compared learning and spatial memory in the APPswe, PSEN1dE985Dbo (APP/PS1) mouse model of AD and studied the ability of acute intraperitoneal and oral Bryostatin-1 to reverse cognitive deficits in this model. Compared to wild-type (WT) mice, APP/PS1 mice showed significant delays in learning the location of a submerged platform in the Morris water maze. Bryostatin-1 was administered over a 2-week course prior to and during water maze testing. Acute i.p. Bryostatin-1 administration did not improve latency to escape but oral Bryostatin-1 significantly improved memory (measured by a reduction in latency to escape). This benefit of oral Bryostatin-1 administration was most apparent during the first 3 days of testing. These findings show that: 1) Bryostatin-1 is orally active in models of learning and memory, 2) this effect can be produced in less than 2 weeks and 3) this effect is not seen with i.p. administration. We conclude that oral Bryostatin-1 represents a novel, potent and long-acting memory enhancer with future clinical applications in the treatment of human AD.

  17. Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis

    Directory of Open Access Journals (Sweden)

    Ueda S

    2016-02-01

    Full Text Available Satoshi Ueda,1 Takeshi Sakayori,1 Ataru Omori,2 Hajime Fukuta,3 Takashi Kobayashi,3 Kousuke Ishizaka,1 Tomoyuki Saijo,4 Yoshiro Okubo1 1Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan; 2Tamachuo Hospital, Tokyo, Japan; 3Kurumegaoka Hospital, Tokyo, Japan; 4Saijo Clinic, Tokyo, Japan Abstract: Neuroleptics can induce not only physical adverse effects but also mental effects that produce deficit status in thought, affect, cognition, and behavior. This condition is known as neuroleptic-induced deficit syndrome (NIDS, which includes apathy, lack of initiative, anhedonia, indifference, blunted affect, and reduced insight into disease. Although this old concept now appears almost forgotten, neuroleptics, whether typical or atypical, can make depression or bipolar disorder resemble other more refractory conditions, readily leading to mistaken diagnosis and inappropriate treatment. The authors describe three cases of NIDS superimposed on depressive phase in bipolar disorder with psychosis, where the attending psychiatrist’s failure to recognize NIDS prevented patients from receiving effective treatment and achieving remission. All cases achieved remission after reduction of neuroleptics and intensive therapy, including electroconvulsive therapy, for bipolar depression. The concept of NIDS was originally introduced for schizophrenia, and it has rarely been highlighted in other diseases. In recent years, however, atypical antipsychotics are being more often administered to patients with bipolar disorder. Psychiatrists, therefore, should also remember and exercise caution regarding NIDS in the pharmacotherapy of bipolar disorder with and without psychosis. The authors believe that the concept of NIDS needs to be reappraised in current psychiatry. Keywords: neuroleptic-induced deficit syndrome (NIDS, bipolar disorder, psychosis, atypical antipsychotics, electroconvulsive therapy

  18. 75 FR 80506 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-12-22

    ... comments should be received within 30 days of this notice. Proposed Project Persistence of Viable Influenza Virus in Aerosols--New--National Institute for Occupational Safety and Health (NIOSH), Centers for... into an aerosol particle collection system. These steps will take about 25 minutes. The airborne...

  19. 78 FR 20110 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-04-03

    ... and Testing a Marketing Strategy for Preventing Alcohol-related Problems in College Communities--NEW... project will address this exact issue by systematically developing a marketing strategy for The Safer... semester of the 2012-2013 academic years, and will constitute a marketing strategy targeting a national...

  20. 78 FR 40151 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-07-03

    ... clearance (OMB Control No. 0920-0802, ABCs, and OMB Control No. 0920-0852, All Age Influenza Hospitalization... the EIPs fall into the following general categories: (1) Active surveillance; (2) applied public... Hemolytic Uremic Syndrome.. 10 10 60/60 Influenza Hospitalization 10 400 15/60 Surveillance Project...

  1. 76 FR 74064 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-11-30

    ... 6,000 12 5/60 Resistance (AUR)- Microbiology Data Electronic Upload Specification Tables. Pharmacy Technician Antimicrobial Use and 6,000 12 5/60 Resistance (AUR)--Pharmacy Data Electronic Upload... 2 Influenza Vaccination Monthly Summary. Clinical Laboratory Technologist... Hemovigilance Module...

  2. 76 FR 12119 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-03-04

    ... 6,000 12 5/60 Resistance (AUR)- Microbiology Data Electronic Upload Specification Tables. Pharmacy Technician Antimicrobial Use and 6,000 12 5/60 Resistance (AUR)-Pharmacy Data Electronic Upload Specification... 2 Influenza Vaccination Monthly Summary. Clinical Laboratory Technologist... Hemovigilance Module...

  3. 77 FR 51808 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-08-27

    ...) outpatient hospitals and clinics nationwide. The BioSense Program also receives pharmacy data from a private... clinical laboratories. The BioSense Program is in the process of transitioning from the original BioSense..., two national-level private sector clinical laboratories, and a private sector health information...

  4. 75 FR 65487 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-10-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND..., and online. More specific types of studies may include: User experience and user-testing; concept...; ethnography/observational studies; and mystery shopping. The data will be used to provide input to the...

  5. 75 FR 53311 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-08-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND..., and online. More specific types of studies may include: User experience and user-testing; concept...; ethnography/observational studies; and mystery shopping. The data will be used to provide input to the...

  6. 76 FR 14021 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-03-15

    ... bacillus that produces two pathogenic toxins: A and B. CDI ranges in severity from mild diarrhea to fulminant colitis and death. Transmission of C. difficile occurs primarily in healthcare facilities, where...

  7. 77 FR 69484 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-11-19

    ... collected in a timely fashion so that information can be used to develop prevention and control techniques... persons holding doctoral degrees. Predicting the number of epidemic investigations that might occur in any... and respondent total of 15,000. After completion of the Epi-Aid investigation, using the Epi-...

  8. 77 FR 35404 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-06-13

    ... should be received within 30 days of this notice. Proposed Project Use of Smartphones to Collect... Description Despite the high level of public knowledge about the adverse effects of smoking, tobacco use remains the leading preventable cause of disease and death in the U.S., resulting in approximately 443,000...

  9. 76 FR 29243 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-05-20

    ... years. The application form and added materials, including an agenda, curriculum vitae, and course... supporting documentation for review by NIOSH staff to ensure the course curriculum meets all current...

  10. 76 FR 39878 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-07-07

    ... years. The application form and added materials, including an agenda, curriculum vitae, and course... supporting documentation for review by NIOSH staff to ensure the course curriculum meets all current...

  11. 77 FR 6802 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-02-09

    ...' socio-demographic characteristics, health seeking actions, HIV/STD and substance use-related risk behaviors, and psychosocial factors at baseline before intervention delivery and 6 months after intervention... psychosocial factors that can increase their vulnerability of HIV/STD infection. This study will use a...

  12. 76 FR 63925 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-10-14

    ... participants' socio-demographic information, health and healthcare, sexual activity, substance use, and other... intervention, elicit recommendations for improving the intervention, and to better understand the factors that...

  13. 76 FR 76733 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-12-08

    ... treatment to eligible individuals, the World Trade Center (WTC) Health Program will collect [[Page 76734... coverage under the new WTC Health Program. In order to begin the determination eligibility process, an... determinations to the WTC Program Administrator and request reimbursement. Data are being collected in order to...

  14. 76 FR 52696 - Paperwork Reduction Act; Proposed Collection; Comment Request

    Science.gov (United States)

    2011-08-23

    ... include the addition of a peer disapproval measure, the removal of the age of first use measure, and a... to complete. Face to face interviews will take 1.5-2 hours and surveys will take approximately...

  15. 77 FR 24960 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-04-26

    ... collection of cheek cells by the mother, father, and infant is estimated to take about 10 minutes per person... (in hours) Mothers NBDPS mother questionnaire. 3,600 1 1 Mothers, fathers, infants Cheek Cell Specimen.... Mothers of case and control infants are interviewed using a computer-assisted telephone interview. The...

  16. 78 FR 72087 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-12-02

    ... cells by the mother, father and infant takes about 15 minutes per person. For the infant sample, the... infants will be randomly selected from birth certificates or birth hospital records; mothers of case and... total of five sponges per infant. The infant's mother and father will be asked to provide their own...

  17. 77 FR 47073 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-08-07

    ... collection requests under review by the Office of Management and Budget (OMB) in compliance with the... requested to conduct the Youth and Adult Biometric Study (YABS), in up to 8 CTG areas that are implementing..., height (i.e., body mass index or BMI), waist circumference, secondhand smoke exposure, and blood pressure...

  18. 75 FR 67366 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-11-02

    ... penicillin, tetracyclines, and fluoroquinolones among N. gonorrhoeae isolates was identified through GISP... fluoroquinolones for treatment of gonococcal infections. There are no costs to respondents other than their time...

  19. 78 FR 55258 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-09-10

    ... days of this notice. Proposed Project Image-Assisted Cytology Workload Assessment and Measure--New... Secretary of Health and Human Services to establish the maximum number of cytology slides that any... artifacts. Today, almost all Pap tests in the U.S. are collected with a liquid-based method. Instead...

  20. 76 FR 61363 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-10-04

    ..., sanitation and hygiene education (WASH) interventions are provided. Sustainability of these WASH interventions is a crucial factor in maintaining the health and well-being of a community. In the Latin American... Program Sustainability Evaluation and Qualitative Interview--NEW--National Center for Environmental...

  1. 75 FR 26257 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-05-11

    ... products, or ever being diagnosed with a pulmonary disease such as emphysema, chronic obstructive pulmonary disorder (COPD), or any type of lung cancer, will be excluded. Prior to their scheduled...

  2. 77 FR 34951 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-06-12

    ... Survey..... 2,000 4 15/60 Employee: Wellness Challenge Log/ Lower Your Weight by 2,000 1 1 Program Participant. Eight Challenge Log. Step into Health 2,000 1 30/60 Challenge Log. Mix it Up Challenge Log. 2,000 1 30/60 Quench Your Thirst 2,000 1 30/60 Challenge Log. Feel Fit with Fiber 2,000 1 30/60...

  3. 76 FR 20353 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-04-12

    ... campaign occurs, the event planners will be asked to respond to a computer-based survey to collect... planners will be asked to note the kind of events that they planned. The survey results are necessary to... activity planners. Awareness Day Evaluation Report. ] Daniel Holcomb, Reports Clearance Officer,...

  4. 75 FR 25859 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-05-10

    ...--Agency for Toxic Substances and Disease Registry (ATSDR), Centers for Disease Control and Prevention (CDC...: Parkinson's disease, kidney failure and other severe kidney diseases, severe liver diseases, lupus, aplastic... cancers, state of diagnosis will also be obtained to facilitate acquisition of cancer registry data....

  5. 75 FR 8723 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-02-25

    ... system (MIS) known as the Management Overview for Logistics, Analysis, and Reporting (MOLAR) system. The... the number of CDC-funded oral health programs. There are no costs to respondents other than their time...

  6. 75 FR 65488 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-10-25

    ... diseases, cholera and other vibrio illnesses, Listeria, babesiosis, brucellosis, Harmful Algal Bloom... Human Rabies Patient Info 50 1 15/60 Waterborne Diseases Outbreak Form 57 1 20/60 Cholera and other... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork...

  7. 75 FR 26256 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-05-11

    ... diseases, cholera and other vibrio illnesses, Listeria, Calcinet, Harmful Algal Bloom-related Infectious... Waterborne Diseases Outbreak Form 57 1 20/60 Cholera and other Vibrio illnesses 450 1 20/60 Outbreak Report... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork...

  8. 77 FR 43286 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-07-24

    ... (data fields) for computer entry. General information, which includes height, weight, age, race, gender... food gardening, fish, game, domestic animals (e.g., chickens). (2) Other sources such as: occupations...

  9. 78 FR 60283 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-10-01

    ..., Health Promotion, and Surveillance Program Announcement: Healthy Communities, Tobacco Control, Diabetes... Brief Description CDC requests OMB approval to continue the collection of information from tobacco... management information system (MIS). There are no changes to the number of tobacco control...

  10. 75 FR 41206 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-07-15

    ... will report on tobacco control, diabetes prevention and control, behavioral risk factor surveillance... per per response respondents respondent (in hours) State Diabetes Program 53 2 6 State Tobacco Program... progress and activity information from health departments funded for four program areas: Tobacco...

  11. 77 FR 52334 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-08-29

    ... Evaluation of ``Teenage Pregnancy Prevention: Integrating Services, Programs, and Strategies through... examine innovative, evidence-based teenage pregnancy prevention programs. Efforts are focused in communities with high rates of teen pregnancy in under- served African American and Latino youth. Components...

  12. 76 FR 44590 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-07-26

    ... construction businesses (SCBs), and to inform methods that will successfully motivate SCB owners to seek OSH... fewer employees. Data gathered from in-depth interviews will provide response content for the... than 10 employees (CPWR, 2007), and this establishment size experiences the highest fatality...

  13. 76 FR 29246 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-05-20

    ... Occupational hazards facing law enforcement officers (LEOs) include psychological, biological, physical, and... enforcement agencies, stratified on size of department (small, medium, and large) and type of department... publically available database of all U.S. law enforcement agencies. Pilot test data demonstrated that...

  14. 75 FR 22138 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-04-27

    ... that truck drivers are at increased risk for lower back pain, heart disease, hypertension, stomach ulcers, and cancers of the bladder, lung, prostate, and stomach. Truck drivers also face extraordinary... name respondents per response respondent (in hours) Truck Drivers Screening Interview 2,457 1 1/60...

  15. 76 FR 60498 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-09-29

    ... information campaign about Helicobacter pylori, a bacterium that can cause stomach ulcers and increase cancer... of screening questions, comprised of demographic and introductory questions, along with other... Interviews), Focus Group Screenings, Focus Groups, Online Surveys Dated: September 19, 2011. Daniel...

  16. 75 FR 33622 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-06-14

    ... suggests that truck drivers are at increased risk for lower back pain, heart disease, hypertension, stomach ulcers, and cancers of the bladder, lung, ] prostate, and stomach. Truck drivers also face extraordinary... respondents responses per response (in respondent hours) Truck Drivers Eligibility Screening 3500 1...

  17. 77 FR 65191 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-10-25

    ... targeting nutrition, physical activity, and obesity (NPAO). A number of Community Transformation Grant (CTG... on the following areas: Audience awareness and recall of local campaigns; reactions to...

  18. 75 FR 39262 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-07-08

    ... green building design features in reducing allergens and toxic substances within the home has been... inflammatory markers. The length of follow-up is one year. Questionnaires regarding home characteristics and... data collection. The number and type of respondents that will complete the questionnaires are...

  19. 76 FR 55393 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-09-07

    ... number of eligible participants, a 6-year Full Study will be conducted following the same study design as... screening questionnaire will be used to assess eligibility and exposure to temporary housing units. The screening questionnaire will be conducted with one adult resident of each selected household. Based...

  20. 75 FR 3737 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-01-22

    ... Questionnaire Design Research Laboratory (QDRL) 2010-2012, (OMB No. 0920-0222 exp. 2/28/2010)--Extension... Questionnaire Design Research Laboratory (QDRL) conducts questionnaire pre-testing and evaluation activities for..., a questionnaire design specialist interviews a volunteer participant. The interviewer...

  1. 78 FR 6327 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-01-30

    ... emergency departments (ED), outpatient departments (OPD), and ambulatory surgery locations (ASLs); and freestanding ambulatory surgery centers (ASCs). The National Center for Health Statistics' (NCHS) surveys on... collection of data from free-standing ambulatory surgery centers. NHAMCS data have been extensively used...

  2. 76 FR 21747 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-04-18

    ... youth is a compelling priority in education and public health. AI/AN individuals develop type 2 diabetes... Youth Books, and the Diabetes Education in Tribal Schools (DETS) curriculum. The Eagle Books are a..., and behaviors; how materials currently support or could be used to support other local diabetes...

  3. 75 FR 57959 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-09-23

    .... Obesity contributes to chronic conditions such as hypertension, Type 2 diabetes, stroke, coronary heart... leaders to encourage healthier diets and more physical activity; and opportunities for leveraging...

  4. 77 FR 50695 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-08-22

    ... Population Affairs (OPA), plans to conduct an evaluation of the diffusion, utilization of, and impact on... will tailor future dissemination activities, and develop needed provider tools, based upon the...

  5. 76 FR 45257 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-07-28

    ... Education and Outreach Program--New-- National Center on Birth Defects and Developmental Disabilities... involuntary motor and vocal tics that typically manifest during childhood. The exact number of people with TS.... Higher prevalence estimates obtained from community studies likely mean that there are a...

  6. 75 FR 53311 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-08-31

    ... research study designed to elucidate patterns of human smoking behavior, quantify biomarkers of exposure to.... Respondents will be asked to participate in a descriptive study of smoking behavior that involves two...

  7. 76 FR 60497 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-09-29

    ... health conditions such as post-traumatic stress disorder (PTSD) (Browne and Finkelhor, 1986; Holmes and..., few studies have utilized standard HRQoL techniques and none have quantified childhood HRQoL impacts... economic evaluation of the HRQoL impacts of CM, including effects specific to juvenile and adolescent...

  8. 78 FR 4149 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-01-18

    ... who is in the communicable period for cholera, plague, smallpox, typhus, or yellow fever or having... 42 Part 70 were developed to facilitate Federal action in the event of large outbreaks requiring a...

  9. 78 FR 33096 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-06-03

    ... (CDC). Background and Brief Description This project involves a questionnaire, along with clinical... the testing session. We also included the time needed to review the informed consent. The overall... natural history of lung disease. For this study, we plan on interviewing and conducting clinical...

  10. 76 FR 63924 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-10-14

    ... change--Division of Tuberculosis Elimination (DTBE), National Center for HIV/AIDS, Viral Hepatitis, STD... journals to further describe and interpret these data. The Food and Drug Administration (FDA) collects...

  11. 77 FR 75167 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-12-19

    ...--National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention (NCHHSTP), Centers for Disease Control... through peer-reviewed journal articles and related presentations. All releases of information will...

  12. 77 FR 71794 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-12-04

    ...) methodological research (4) usability testing of technology-based instruments and materials, (5) field testing of... research on survey methods may be selected purposively or systematically from within an ongoing... this notice. Proposed Project Formative Research and Tool Development--(OMB 0920-0840, Exp....

  13. 78 FR 35635 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-06-13

    ... collection method will be used to perform usability testing on any interfaces designed by the Cognitive.... Finally, a Roof Bolter Questionnaire was added to the research plan to assess and determine the usability... inclusion of Human Systems Integration into research related to underground coal mining: (1)...

  14. 78 FR 52771 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-08-26

    ... similar cultural and geographic features yet different public health and mental health emergency response... primary research questions will guide the proposed study: 1. How did the Alabama and Mississippi State and... includes two main components (qualitative and quantitative) designed to comprehensively examine the PH/MH...

  15. 78 FR 65655 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-11-01

    ... a spreadsheet that each mine site can open on a computer that has the appropriate software. It is... gathered, a variety of statistical and qualitative analyses will be conducted on the data to obtain... Office, Office of Scientific Integrity, Office of the Associate Director for Science, Office of...

  16. 78 FR 23766 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-04-22

    ... were found in Anniston adults who had high blood pressure and diabetes. ATSDR and National Institutes..., demographic, diet, and lifestyle factors. The self- reported responses will be compared to laboratory analytes... will include measures for thyroid, diabetes, lipids, and immune function. This will give a...

  17. 78 FR 23767 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-04-22

    ... were found in Anniston adults who had high blood pressure and diabetes. ATSDR and National Institutes..., demographic, diet, and lifestyle factors. The self- reported responses will be compared to laboratory analytes... will include measures for thyroid, diabetes, lipids, and immune function. This will give a...

  18. 78 FR 22551 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-04-16

    ..., surveillance, and evaluation of risk behaviors and health conditions, as well as targeted dissemination of... numbers from a frame of known cell phone exchanges. Respondents reached on their cell phones will be asked... data collected via CATI to data collected via smartphones/text messages; (3) coverage bias...

  19. 75 FR 10803 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-03-09

    ... estimated in the 1970s and 1980s by CDC's Study on the Efficacy of Nosocomial Infection Control (SENIC), in... data, limited to basic demographic and risk factor/ antimicrobial use information. We anticipate that... Associated Infections (HAIs) and ] Antimicrobial Use in U.S. Acute Care Hospitals--New--National Center...

  20. 77 FR 76045 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-12-26

    ..., clinical and laboratory markers of HIV disease, manifestations of severe HIV disease, and deaths among... addition, this national system provides essential data to estimate HIV incidence and monitor patterns in... laboratories, health care providers, and medical records. CDC estimates that 25 health departments will be...

  1. 76 FR 12964 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-03-09

    ... work, disruption in the fishing and tourism industries, and the effect on the physical environment in... Survey. Addition of a Spanish translation of the questionnaire. Minor modifications in the wording...

  2. 75 FR 6205 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-02-08

    ... assessing the children into older adolescence. This program extends data collection for two additional waves... 10/60 Knowledge. Parent ADHD Treatment, Cost, and 190 1 10/60 Client Satisfaction Questionnaire... of Life Child 15 1 5/60 (8-12). Child Pediatric Quality of Life Teen 175 1 5/60 (13+). Child Youth...

  3. 77 FR 508 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-01-05

    ... , a panel that uses address-based postal mail sampling to generate a probability-based online panel of... estimate the extent to which smokers and non-smokers in the U.S. were exposed to The Campaign and to... questionnaires involving adult smokers and non-smokers in the U.S., ages 18-54. Respondents who are smokers will...

  4. 77 FR 27064 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-05-08

    ..., NCHS is requesting approval for a large field test that will be conducted in 2012. This is a 5,000-case... ACASI content included in the 5,000-case test is consistent with the content studied in two smaller... behaviors, health status, and health care utilization of Lesbian, Gay, Bisexual, and Transgender...

  5. 76 FR 5378 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-01-31

    ..., history, and culture. Example activities include the cultivation of community gardens, organization of... Native Communities--New--National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP... for Health Promotion and Diabetes Prevention in American Indian/Alaska Native Communities.''...

  6. 76 FR 78925 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-12-20

    ... address this situation, the Air Pollution and Respiratory Health Branch of CDC wishes to conduct a study... parents of children with asthma) receive at their initial diagnosis encounter with the medical system....

  7. 78 FR 4411 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-01-22

    ... first assessment of the experiences of parents whose children were screened for CMV at birth... CMV: Parent Group 1 (PG1)--Child screened positive for congenital CMV at birth, asymptomatic at birth, but did not develop sequelae Parent Group 2 (PG2)--Child screened positive for congenital CMV at...

  8. 75 FR 22137 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-04-27

    ... group participants. Formative research participants will include (1) parents of young children (aged 5... 16-19 years). Participants will include (1) parents of young children (aged 5-12 years) and (2...--National Center on Birth Defects and Developmental Disabilities (NCBDDD), Centers for Disease Control...

  9. 76 FR 28233 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-05-16

    ... comments should be received within 30 days of this notice. Proposed Project Crime Prevention Through... and Fear--New--National Center for Injury Prevention and Control (NCIPC), Centers for Disease Control... developed an observational tool called the Crime Prevention Through Environmental Design (CPTED)...

  10. 77 FR 51809 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-08-27

    ... intimate relationships; approximately 14% of females who were stalked by an intimate partner in their... should be received within 30 days of this notice. Proposed Project National Intimate Partner and Sexual... health burden of Intimate Partner Violence (IPV), Sexual Violence (SV) and stalking are substantial. To...

  11. 78 FR 75568 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-12-12

    ..., attitudes, and behaviors (KAB) of key professional audiences who are involved in the immediate aftermath of... this notice. Proposed Project Chemical Emergencies Audience Analysis--New--Agency for Toxic Substances... the following professional audiences for this research: First responders, including police,...

  12. 75 FR 38104 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-07-01

    .... Other variables for segmentation may include, but not be limited to, geography and language. Two youth... estimated burden hours are 1354. Estimated Annualized Burden Hours Number of Average burden Type of respondents Data collection type Number of responses per per response respondents respondent (in hours)...

  13. 77 FR 65192 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-10-25

    ... Prevention Registered Nurse 6,000 24 10/60 Process and Outcome Measures Monthly (Infection Monitoring... (Infection Preventionist). 57.137: Long-Term Care Facility Registered Nurse 250 1 45/60 Component--Annual... Measures Registered Nurse 250 12 5/60 Monthly Monitoring for LTCF. (Infection Preventionist). 57.150: LTAC...

  14. 78 FR 52533 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-08-23

    .../60 Preventionist). Prevention Process and Outcome Measures Monthly Monitoring. Registered Nurse... Nurse (Infection 57.137: Long-Term Care 250 1 45/60 Preventionist). Facility Component-- Annual Facility...). Prevention Process Measures Monthly Monitoring for LTCF. Registered Nurse (Infection 57.140: Urinary Tract...

  15. 77 FR 76044 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-12-26

    ... participating in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP), also administered by... improvement. CDC uses the MDE data to assess the effectiveness of the WISEWOMAN program in ] reducing the... should be received within 30 days of this notice. Proposed Project Well-Integrated Screening...

  16. 75 FR 11184 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-03-10

    ... structure (ROPS). It is estimated that about half of the 4.8 million tractors in the United States currently do not have ROPS installed. Earlier research indicated that adoption of retrofit ROPS technology for... tractor after the retrofitting (installation), of a ROPS. To overcome these barriers, NIOSH designed a...

  17. 77 FR 58843 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-09-24

    ... agreement with the CDC. Prenatal exposure to alcohol is a leading preventable cause of birth defects and... health Arctic RTC Foundations Pre 30 1 15/60 professionals and students. Foundations Post 30 1...

  18. 75 FR 16128 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-03-31

    ... programs and policies targeting improved eating habits and physical activity levels among children in low... children is affected by overweight or obesity in the United States, making it the most prevalent... vegetables. In response to this growing public health crisis, the Division of Nutrition, Physical Activity...

  19. 76 FR 18553 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-04-04

    ... delivering particular individual- or group-level behavioral interventions. This is done by monitoring changes... (CBO) Monitoring and Evaluation Project (CMEP) of Women Involved in Life Learning from Other Women... prevention because of their history and credibility with target populations and their access to groups that...

  20. 77 FR 28881 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-05-16

    ... cervical cancer screening strategy involves administration of both the Pap test and a human papillomavirus... 30 days of this notice. Proposed Project CDC Cervical Cancer Study (CX3)(OMB No. 0920-0814, exp. 6/30... Cervical Cancer Early Detection Program (NBCCEDP) is the only organized national screening program in...

  1. 75 FR 4824 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-01-29

    ... evaluate cervical cancer screening methods and the use of Human Papillomavirus DNA tests. A supplemental.... In addition, information on cervical cancer screening practices in physician offices will continue to be collected through the Cervical Cancer Screening Supplement (CCSS), which was added in 2006....

  2. 76 FR 2393 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-01-13

    ... Brief Description The Centers for Disease Control and Prevention (CDC), Office on Smoking and Health (OSH) has the primary responsibility for the Department of Health and Human Services (HHS) smoking and... health effects of these ingredients. In this Extension request, there no changes to the estimated...

  3. 77 FR 40362 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-07-09

    ... Brief Description The Centers for Disease Control and Prevention (CDC), Office on Smoking and Health (OSH) has the primary responsibility for the Department of Health and Human Services (HHS) smoking and... research, and to report to Congress, as deemed appropriate, about the health effects of these...

  4. 77 FR 4044 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-01-26

    ... include breast and cervical cancer; cardiovascular disease; diabetes mellitus; adult/older adult immunization, hepatitis B, and/or tuberculosis; asthma; and infant mortality. Priority populations for...

  5. 75 FR 80055 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-12-21

    ... cervical cancer screening and diagnostic exams to over 3.7 million low-income women. Those who are... Breast and Cervical Cancer Early Detection Program--Revision--Division of Cancer Prevention and Control... Cervical Cancer Early Detection Program (NBCCEDP), the largest organized cancer screening program in...

  6. 75 FR 3737 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-01-22

    ... referrals. The WISEWOMAN program serves women who are participating in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP), also administered by CDC. CDC requests OMB approval to continue... disease incidence and risk-factors, improve the availability of screening and diagnostic services...

  7. 77 FR 17063 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-03-23

    ... patients were not sampled for participation in MMP more than once), to assess nonresponse bias, to... instruments have been revised based on experience in previous data collection cycles, but these changes...

  8. 78 FR 68074 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-11-13

    ... Abuse and Mental Health Services (SAMHSA) Prescription Drug Monitoring Program (PDMP) Electronic Health... PDMP data with Health Information Technology (HIT) systems and interoperability of PDMP systems across... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  9. 75 FR 17410 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-04-06

    ... occupational hazards (e.g., explosions, falls of ground). Survey results will provide NIOSH with knowledge... collection requests under review by the Office of Management and Budget (OMB) in compliance with the... Officer, Office of Management and Budget, Washington, DC or by fax to (202) 395-5806. Written comments...

  10. 77 FR 11539 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-02-27

    ... vary greatly in quality and effectiveness. To address the gaps, CDC has developed Dating Matters, a... 11 to 14 years; middle school parents; brand ambassadors; educators; school leadership; program.... Brand Ambassadors: The Brand Ambassador Implementation Survey will be provided to each brand ambassador...

  11. 76 FR 65512 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-10-21

    ..., these activities vary greatly in quality and effectiveness. To address the gaps, CDC has developed... school students age 11 to 14 years; middle school parents; brand ambassadors; educators; school... number of respondents for the Safe Dates implementer survey will be 144. Brand Ambassadors: The Brand...

  12. 78 FR 9695 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-02-11

    ... ``biggest bang for the buck.'' The study focuses on thirteen interventions. These interventions are: 1. Red... restraint/booster or seat belt law enforcement, 8. Motorcycle helmet use laws, 9. Primary enforcement...

  13. 76 FR 13191 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-03-10

    ...-Producing E. coli Study: Assessment of Risk Factors for Laboratory-Confirmed Infections and Characterization... severity from mild diarrhea, to hemorrhagic colitis and in some cases, life-threatening hemolytic uremic...

  14. 78 FR 35272 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-06-12

    ... respondents will be Latina Spanish-dominant women of childbearing age (ages 18-45, both childless adult women... care Moderator's Guide....... 10,000 1 1 providers. General public and health care Surveys 5,000 1...

  15. 78 FR 44568 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-07-24

    ..., whether more books like Amazing Me for other age groups should be developed, and if the ROR book... Moderator... 54 1 1 -- Leroy A. Richardson, Chief, Information Collection Review Office, Office...

  16. 78 FR 21160 - Paperwork Reduction Act; 30-Day Notice

    Science.gov (United States)

    2013-04-09

    ... advertising effectiveness (OMB 3201-0010)--are critical to the continuity and improvement of the Media... instruments used in the production of ONDCP's National Youth Anti-Drug Media Campaign advertising and Media Campaign advertising tracking. Purpose: The National Youth Anti-Drug Media Campaign is in the process of...

  17. 78 FR 68848 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-11-15

    ... National Prevention Information Network--Revision--National Center for HIV/AIDS, Viral Hepatitis, STD, & TB... National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) proposes to continue data... and control of HIV infection, viral hepatitis, sexually transmitted diseases (STDs), and tuberculosis...

  18. 78 FR 64942 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-10-30

    ... HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and... undetectable viral load, who are adherent to antiretroviral therapy (ART), who attend clinic regularly for... viral load, i.e., their viral load is not as low as it can be and is not fully controlled. The...

  19. 77 FR 55478 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-09-10

    ... chronic conditions and risk factors related to health such as arthritis, asthma, osteoporosis, infectious diseases, diabetes, high blood pressure, high cholesterol, obesity, smoking, drug and alcohol use, physical.... NHANES continues to collect genetic material on a national probability sample for future genetic...

  20. 77 FR 64808 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-10-23

    .... NHANES monitors the prevalence of chronic conditions and risk factors related to health such as arthritis, asthma, osteoporosis, infectious diseases, diabetes, high blood pressure, high cholesterol, obesity... health of the U.S. population over time. NHANES continues to collect genetic material on a...

  1. 78 FR 9697 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-02-11

    ... campaign advertisements, knowledge, attitudes, and beliefs related to smoking and secondhand smoke. In... variables of interest which will include knowledge, attitudes, beliefs and intentions related to smoking...

  2. 78 FR 49523 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-08-14

    ... Breastfeeding-Related Maternity Care Practices in Intra-partum Care Facilities in the United States and... breastfeeding rates across population subgroups. Because hospital practices strongly influence infant feeding... breastfeeding initiation rates. In 2007, CDC conducted the first national survey of Maternity Practices in...

  3. 75 FR 58394 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-09-24

    ... Breastfeeding-Related Maternity Care Practices in Intra-partum Care Facilities in the United States and... Brief Description Substantial evidence demonstrates the health benefits of breastfeeding. Breastfeeding mothers have lower risks of breast and ovarian cancers and type 2 diabetes, and breastfeeding better...

  4. 75 FR 8725 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-02-25

    ... comments should be received within 30 days of this notice. Proposed Project CDC Web site and Communication... Marketing (NCHM), Centers for Disease Control and Prevention, (CDC). Background and Brief Description... usability surveys on CDC Web sites, social media, mobile-based or other electronic communication...

  5. 78 FR 17409 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-03-21

    ... serious consequences for victims, families, and communities. IPV occurs between two people in a close... Annualized Burden to Respondents Number of Average burden Type of respondents Form name Number of responses... episode of violence to ongoing battering; many victims do not report IPV to police, friends, or family...

  6. 77 FR 28597 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-05-15

    ... surgery centers (FSASC) will collect data using methods approved for the National Hospital Ambulatory..., funded by the Center for Behavioral Health Statistics & Quality (CBHSQ) of the Substance Abuse & Mental...-- National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC)....

  7. 76 FR 66070 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-10-25

    ...' offices and hospital outpatient and emergency departments, and ambulatory surgery centers. The target... children's general, as well as visits to freestanding ambulatory surgery centers (FS-ASCs). The objectives... (EDs), and ambulatory surgery locations (ASLs) of non-Federal, short-stay hospitals (hospitals with...

  8. 77 FR 72867 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-12-06

    ..., diabetes, and access to health care. It is a leading source of data for the Congressionally-mandated... Child Core (adult family member) 17,000 1 10/60 Child/Teen Record Check (medical provider) 10,000 1...

  9. 76 FR 17867 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-03-31

    ... Management Agency (FEMA) assumed the primary role for housing displaced persons over the intermediate term..., and mobile homes for persons displaced by the above mentioned storms. However, some persons living in... Individuals Displaced by the Hurricanes Katrina and Rita (Pilot Project)--New--Agency for Toxic Substances...

  10. 77 FR 2730 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-01-19

    ... Nutrition, Physical Activity and Obesity Programs and Policies--New--National Center for Chronic Disease... Nutrition, Physical Activity and Obesity (NPAO) cooperative agreement program, states and jurisdictions that... Brief Description The causes of obesity in the United States are complex and numerous, and they occur at...

  11. 77 FR 65552 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-10-29

    ... racial and ethnic minorities. The goals of this project are to evaluate: (1) The degree of exposure of... on health and safety outcomes and (3) the organizational (e.g., organizational characteristics... interview. Respondents will be asked about: (1) Their exposure to workplace and job stressors, including...

  12. 78 FR 69854 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-11-21

    ..., biological, chemical, nuclear, radiological) characterized by undetermined agents, undetermined sources, undetermined transmission, or undetermined risk factors. These EEIs represent a subset of those performed under... events characterized by undetermined agents, undetermined sources, undetermined transmission, or...

  13. 77 FR 38065 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-06-26

    ... days of this notice. Proposed Project Communications Research for the Development of Messages and... neural tube defects, and can include hearing or vision loss, mental retardation, psychomotor delays, and... CDC's development of materials and prevention messaging about congenital CMV. The...

  14. 76 FR 51982 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-08-19

    ... in mines, researchers at the NIOSH-Pittsburgh Research Laboratory (PRL) have found that one of the..., including: the diversity of instances, the number of instances (base rates) needed to improve accuracy in... research with a total of 28 students from Carnegie Mellon University and the University of Pittsburgh...

  15. 76 FR 74066 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-11-30

    ... comments should be received within 30 days of this notice. Proposed Project Evaluation of Core Violence and... consequences, including unintentional and violence-related injuries, are the leading cause of death for the first four decades of life, regardless of gender, race, or socioeconomic status. More than...

  16. 78 FR 9699 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-02-11

    ... strive to ensure a high response rate by promoting the survey through advertisements in laboratory trade... characteristics including laboratory specialty and laboratory type for each laboratory. The survey will...

  17. 78 FR 24422 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-04-25

    ... many states have asthma interventions targeting schools, how many children are treated in emergency... days of this notice. Proposed Project Asthma Information Reporting System (AIRS) (0920-0853, Expiration... approval for the Asthma Information Reporting System (AIRS) information collection. In 1999, the...

  18. 77 FR 45616 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-08-01

    ... time during the visits for discussion and strategic planning. Findings from this project will be used... Control and Prevention (CDC) publishes a list of information collection requests under review by the... communities to increase their knowledge, skills, technology, and infrastructure to implement and sustain...

  19. 76 FR 2123 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-01-12

    ...; preventing teen pregnancy; and preventing HIV. CDC's priorities for approaching improvements to public health... disability in the United States, including a focus on tobacco control; improving nutrition, physical...

  20. 77 FR 61406 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-10-09

    ... the coal mining industry. In recent years, coal mining safety has attained national attention due to... mining to meet its electricity needs. For this reason, the coal mining industry must continue to find... practices or the enhancement of existing safety practices across the underground coal mining industry....

  1. 76 FR 24028 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-04-29

    ... should be received within 30 days of this notice. Proposed Project School Health Policies and Practices... conducted at the state, district, school, and classroom levels in 1994 (OMB. No. 0920-0340, exp. 1/31/1995... two at the classroom level. Data collection at the state and district levels will be...

  2. 75 FR 6671 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-02-10

    .../31/10. In June 2009, all Matter of Balance programs implemented a new consent form. This form asked... survey. For this reason, we will not begin administering the follow-up survey to Matter of Balance... adults (Stepping On, Moving for Better Balance and Matter of Balance) and to assess the maintenance...

  3. 78 FR 65323 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-10-31

    ... leading to nicotine addiction and dependence. Furthermore, SLT use is not a safe substitute for cigarette smoking. Adolescents who use smokeless tobacco are more likely to become cigarette smokers. The Centers.... Electronic mail submissions are not accepted. Annual submission reports are mailed to: Office on Smoking...

  4. 77 FR 12595 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-03-01

    ... leading to nicotine addiction and dependence. Furthermore, SLT use is not a safe substitute for cigarette smoking. Adolescents who use smokeless tobacco are more likely to become cigarette smokers. The Centers... letterhead, by CD, three-inch floppy disk, or thumb drive. Electronic mail submissions are not accepted....

  5. 75 FR 70007 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-11-16

    ... leading to nicotine addiction and dependence. Furthermore, SLT use is not a safe substitute for cigarette smoking. Adolescents who use smokeless tobacco are more likely to become cigarette smokers. The Centers... on the respondent's letterhead, by CD, three-inch floppy disk, or thumb drive. Electronic...

  6. 78 FR 11886 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-02-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND... days of this notice. Proposed Project Evaluation of Dating Matters: Strategies to Promote Healthy Teen Relationships TM (OMB 0920-0941, Expiration 06/30/ 2015)--REVISION--National Center for Injury Prevention...

  7. 78 FR 22552 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-04-16

    ... support domestic public health objectives for treatment of tuberculosis (TB), prevention of multi- drug... tuberculosis and Nontuberculous Mycobacteria Drug Susceptibility Testing OMB 0920-0600 (exp. 5/31/2013... tuberculosis and Non-tuberculous Mycobacterium Drug Susceptibility Testing. This request includes (a) changing...

  8. 78 FR 42078 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-07-15

    ... Program Managers. Follow-up and Treatment 100 1 (electronic)..... 30/60 of Contacts to Tuberculosis Cases Form. Program Managers Follow-up and Treatment 18 1 (manual)......... 30/60 of Contacts to Tuberculosis Cases Form. Data clerks Follow-up and Treatment 18 1 (manual)......... 3 of Contacts to Tuberculosis...

  9. 75 FR 43986 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-07-27

    ... Treatment of 18 1 (manual) 3 Contacts to Tuberculosis Cases. Program Managers Follow-up and 50 1 (electronic)....... 30/60 Treatment of 18 1 (manual) 30/60 Contacts to Tuberculosis Cases. Data clerks Targeted Testing and 50 1 (electronic)....... 30/60 Treatment for Latent 18 1 (manual) 3 Tuberculosis Infection...

  10. 75 FR 14164 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-03-24

    ... health objectives for treatment of tuberculosis (TB), prevention of multi-drug resistance, and... for Mycobacterium tuberculosis and Non-tuberculous Mycobacterium Drug Susceptibility Testing (OMB... currently approved data collection, the Model Performance Evaluation Program for Mycobacterium tuberculosis...

  11. 78 FR 21126 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-04-09

    ... designed to collect information about work history, workplace exposures and asthma health from workers in... days of this notice. Proposed Project Research to Inform the Prevention of Asthma in Healthcare--New... that healthcare workers have an elevated risk for work-related asthma (WRA) associated with exposure...

  12. 78 FR 57640 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-09-19

    ... use a creative method to collect relevant stories on the impacts of the Public Health Emergency... order to describe the current successes and challenges public health officials face implementing the... compelling story, a headline, and up to three key bullet points. The intent of this template is to guide the...

  13. 76 FR 51984 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-08-19

    ... services. Mass media (e.g., television, radio, print) has been shown to be the most important and... used to minimize burden to respondents. Participating states will provide CDC with media purchasing...

  14. 78 FR 40742 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-07-08

    ... ecological model. State Domestic Violence Coalitions (SDVCs) must facilitate and support local-level implementation and hire empowerment evaluators to support the evaluation of IPV prevention strategies by the CCRs. SDVCs must also implement and with their empowerment evaluators, evaluate state-level IPV...

  15. 78 FR 9699 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-02-11

    ... (such as lean manufacturing) are changing the nature of labor-intensive work, prevention of MSDs will be... Manufacturing sector. Musculoskeletal disorders (MSDs) represent a major proportion of injury/illness incidence and cost in the U.S. Manufacturing (MNF) sector. In 2008, 29% of non-fatal injuries and illnesses...

  16. 77 FR 12594 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-03-01

    ..., the Great Lakes Water Quality Agreement listed 40 Areas of Concern (AOCs) representing the most... compared to available national estimates. This program also aims to take these measures from people who may... Rivers. Each state will use its own way to ask people to take part in the study. In Michigan, people...

  17. 78 FR 44566 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-07-24

    ... curriculum will be based on a problem-solving approach to improving employer knowledge and skills related to... skill-based training to them; (2) Increase employers' level of knowledge and awareness of workplace... workplace health promotion training program, to support employers' efforts to create healthy work...

  18. 78 FR 35933 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-06-14

    ... closed-circuit breathing apparatus (e.g., Dr ger BG4). To accomplish these goals over the life of the... post-test instruments for assessing trainee reaction and measuring learning. Data collection will take... safety and health skills. To assess learning as a result of training, each participant will complete...

  19. 78 FR 26032 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-05-03

    ... health burden of Intimate Partner Violence (IPV), Sexual Violence (SV) and stalking are substantial. To... Sexual Violence Survey (NISVS) which produces national and state level estimates of Intimate Partner Violence (IPV), Sexual Violence (SV) and stalking on an annual basis. The National Intimate Partner...

  20. 78 FR 23765 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-04-22

    ... surveillance data for United States Cancer Statistics (USCS), which CDC has published annually since 2002. CDC...). The NPCR Program Evaluation Instrument (PEI) is a secure, web-based method of collecting information..., Director, Office of Scientific Integrity, Office of the Associate Director for Science, Office of...

  1. 75 FR 46942 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-08-04

    ... the betterment of workers. Developing and supporting a new generation of practitioners is critical to... continually changing nature of the workplace, over the last 38 years NIOSH has sponsored 3 OS&H workforce...

  2. 78 FR 47699 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-08-06

    ... Administration (OSHA) to revise the Bloodborne Pathogens (BBP) Standard to establish requirements that employers... bloodborne disease in the course of their work. However, exposure control plans for bloodborne pathogens... work will draw on research-to-practice principles and will be assisted by a strong network of...

  3. 78 FR 18595 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-03-27

    ... screening is effective in reducing CRC incidence and mortality, regular CRC screening is now recommended for adults starting at age 50 and continuing until age 75 years. In 2005, CDC established a three-year..., incidence and mortality. Funded sites implement evidence-based interventions to increase...

  4. 77 FR 6803 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-02-09

    ... National Health and Nutrition Examination Survey (NHANES) 1999- 2010 Birth Certificate Linkage Study.... Division of Health and Nutrition Examination Surveys (DHANES) proposes to re-contact women who were... insight into issues related to maternal and child health. No other survey has the physical examination...

  5. 77 FR 40887 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-07-11

    ... all patient visits at participating STD clinics. The second is a population-based surveillance in which a sample of individuals reported with gonorrhea to the 12 SSuN state or city health departments... registration, during the clinic encounter, or through laboratory testing. For the population-based...

  6. 78 FR 53461 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-08-29

    ... capacity building assistance to physicians, nurses, disease intervention specialists, health educators and... triage and assign CBA provider requests. The 7,400 respondents represent an average of the number...

  7. 77 FR 28882 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-05-16

    ... communication of risk information. The purpose of the proposed Reader Response Postcard is to obtain feedback..., averaging 8,000/yr. Researchers from NIOSH propose to routinely include a Reader Response postcard with notification materials to assess the value and usefulness of said materials. The Reader Response postcard...

  8. 77 FR 70782 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-11-27

    ... Indirect/Non-Medical Cost Study-- New--National Center for Chronic Disease Prevention and Health Promotion.... Participation in the study is voluntary, but patients will be offered an incentive in the form of a gift card...

  9. 75 FR 43988 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-07-27

    ... how interpersonal communication with members of one's social networks are related to risk for... should be received within 30 days of this notice. Proposed Project Exploring HIV Prevention Communication... with men (MSM) in New York City. The purpose of the proposed study is to assess how...

  10. 75 FR 37445 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-06-29

    ... their attitudes towards HIV testing, socio-cultural norms, and perceived behavioral control factors that...-cultural norms, and perceived behavioral control factors to HIV testing intentions and behaviors. The... development of HIV prevention interventions for young black men. There is no cost to respondents except...

  11. 76 FR 78924 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-12-20

    ... an optimal mix of evidence-based behavioral, biomedical, and structural interventions to have maximum....g., National HIV Behavioral Surveillance System, Medical Monitoring Project) that routinely collect... Enhanced Comprehensive HIV Prevention Plan (ECHPP) Project -New- National Center for HIV/AIDS,...

  12. 75 FR 25860 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-05-10

    ... to develop and pilot-test three novel behavioral interventions to reduce sexual risk for HIV... Prevention Intervention Targeting Black Bisexually-Active Men--New--National Center for HIV/AIDS, Viral.... Results from the National HIV Behavioral Surveillance Project showed that during 2001-2004...

  13. 78 FR 307 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-01-03

    ... information, budget data, intervention information, and client demographics and behavioral risk... National HIV Prevention Program Monitoring and Evaluation (NHM&E) (OMB 0920-0696, Expiration 08/31/2013)--Revision--National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers...

  14. 76 FR 17869 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-03-31

    ... epidemic, including the diffusion and implementation of Effective Behavioral Interventions (EBIs) for HIV... intervention) to assess their HIV and STD related attitudes and behavioral risks. CBOs will be expected to... delivering particular individual- or group-level behavioral interventions by monitoring changes in...

  15. 75 FR 48349 - Agency Forms Undergoing Paperwork Reduction Act review

    Science.gov (United States)

    2010-08-10

    ... public health surveillance data using methods that detect abnormal trends that could possibly indicate an... releases for upgrades and enhancements; track the number of users, the download frequency, and the type of... enhancements. There is no cost to respondents to participate in this program. The total estimated...

  16. 75 FR 64732 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-10-20

    ... Orders, Postcard Survey for Bulk Mailing, Web Survey for Internet Publication Orders, Web Survey for E... satisfaction surveys. The Interactive Voice Response Survey--offered in English and Spanish and the Web Survey for E-Mail Inquirers--offered in English and Spanish. Both surveys underwent minimal changes....

  17. 76 FR 29245 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-05-20

    ...--New--Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health... Diabetes is one of the most common chronic diseases among children in the United States. When diabetes... HUMAN SERVICES Centers for Disease Control and Prevention Agency Forms Undergoing Paperwork...

  18. 75 FR 80505 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-12-22

    ... Prevent Workplace Violence in Convenience Stores--NEW--National Institute for Occupational Safety and... and robbery-related injury risk to both employees and customers in retail settings. These programs... effectiveness of convenience store safety ordinances in Dallas and Houston, Texas. The goals of this...

  19. 75 FR 4568 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-01-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND... disease; (3) better outline key demographic factors (such as age, race or ethnicity, gender, and family... advertised by ATSDR and advocacy groups such as the Amyotrophic Lateral Sclerosis Association (ALSA) and...

  20. 78 FR 26780 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-05-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND... disease; (3) better outline key demographic factors (such as age, race or ethnicity, gender, and family...://wwwn.cdc.gov/als ) is being advertised by ATSDR and advocacy groups such as the Amyotrophic...

  1. 76 FR 23818 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-04-28

    ... Marketing Campaign Phases Targeting Consumers--New--National Center for HIV/AIDS, Viral Hepatitis, STD and... social marketing messages aimed at increasing HIV awareness and delivering HIV prevention and testing messages among at-risk populations. This study will evaluate the AAA social marketing campaign aimed...

  2. 76 FR 16629 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-03-24

    ... Marketing Campaigns--Routine HIV Testing for Emergency Medicine Physicians, Prevention Is Care (PIC), and Partner Services--Extension--(0920-0775, expiration 4-30- 2011) National Center for HIV/AIDS, Viral... efforts in further developing three social marketing campaigns targeting infectious disease...

  3. 76 FR 78262 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-12-16

    ... among Men who have Sex with Men-- New--National Center for HIV/AIDS, Viral Hepatitis, STD, and TB... direct marketing method that utilizes selective placement of banner advertisements on non-profit...

  4. 76 FR 19363 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-04-07

    ..., State, Territorial, and Tribal Education Agencies in HIV Prevention, Coordinated School Health Program..., territorial, and Tribal government education agencies (SEAs, TEAs, and TGs) funded by the Division of... development activities, provision of technical assistance, collaboration with external partners, and...

  5. 76 FR 19364 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-04-07

    ... Mycobacterium tuberculosis and about 10% of these persons will develop tuberculosis (TB) disease at some point in their lives. The purpose of this project is to continue ongoing national tuberculosis surveillance... Tuberculosis (RVCT), (OMB No. 0920-0026) exp. 05/31/2011--Extension--National Center for HIV/AIDS,...

  6. 75 FR 67374 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-11-02

    ... injuries to home care workers showing an injury rate which was 50% higher than that of workers employed in... conditions and occupational exposures, work related injuries, knowledge of work-related health risks and... workers on their job satisfaction and clients on their satisfaction with caregiver services, on...

  7. 77 FR 58142 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-09-19

    ... year. Official publications of national violent death rates, e.g. those in Morbidity and Mortality... case records held by medical examiners/ coroners, police, and crime labs. Data is collected...

  8. 78 FR 52770 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-08-26

    ... will provide insights into customer or stakeholder perceptions, experiences and expectations, provide... activity will garner qualitative customer and stakeholder feedback in an efficient, timely manner, in... mean information that provides useful insights on perceptions and opinions, but are not...

  9. 75 FR 52952 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-08-30

    ... as case finding, records abstraction, follow-up, quality assurance, professional development, travel... hours and minutes dedicated to case finding, records abstraction, follow-up, and quality assurance, and... registrar will estimate the amount of time dedicated to auditing, database management, professional...

  10. 78 FR 65652 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-11-01

    ... exposure, laboratory content related to fluoride exposure, and collection of HPV swabs for males. The... and creatinine levels will be measured. Other analyses of the urine are being considered: Fluoride... Hours and Costs Average Number of Number of burden per Type of respondent Form respondents responses per...

  11. 76 FR 41260 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-07-13

    ... United States. The following are eligible for the study: 1) 832 children (age 7-12 years with asthma and..., pesticides, VOCs, indoor allergens, fungi, temperature, humidity, and particulate matter. To...

  12. 77 FR 17064 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-03-23

    ... descriptive statistics which measure factors associated with birth and pregnancy rates, including.../ ACF/CB); the ACF's Office of Planning, Research, and Evaluation (OPRE); the CDC's Division of HIV/AIDS.... The NSFG is also used by state and local governments; private research and action organizations...

  13. 78 FR 16269 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-03-14

    ... collection requests under review by the Office of Management and Budget (OMB) in compliance with the... send an email to omb@cdc.gov . Send written comments to CDC Desk Officer, Office of Management and... activities include laboratory training, classroom study, online training, and distance learning. CDC uses two...

  14. 78 FR 34385 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-06-07

    ... collection requests under review by the Office of Management and Budget (OMB) in compliance with the... send an email to omb@cdc.gov . Send written comments to CDC Desk Officer, Office of Management and..., district, school, and classroom levels in 1994 (OMB No. 0920-0340, exp. 1/31/1995), 2000 (OMB No. 0920-0445...

  15. 75 FR 47818 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-08-09

    ... victimization and perpetration of teen dating violence in one rural North Carolina school district, but... participation from teachers at eight schools who delivered the Safe Dates program and students at one school who... program needs modification/adaptation for urban, high-risk adolescents. Approximately 40 students at...

  16. 75 FR 12753 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-03-17

    ... of laboratory tests available certainly warrant such a model. The Laboratory Medicine Best Practices.... The Workgroup has been supported by staff at CDC and the Battelle Memorial Institute under contract to... obtain and critically appraise published and unpublished data. A pilot test of a standardized data...

  17. 78 FR 9698 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-02-11

    ... of laboratory tests available certainly warrant such a model. The Laboratory Medicine Best Practices... supported by staff at CDC and the Battelle Memorial Institute under contract to CDC. To date, the Laboratory... evidence reviews using published literature, and completed a proof-of-concept test. Results of an extensive...

  18. 78 FR 33095 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-06-03

    ... sources of sodium intake exists by socio-demographic subgroups, and better inform estimates of salt added... sodium from processed and restaurant foods, sodium inherent in foods, and salt added at the table and... questionnaire, a tap water questionnaire, four 24-hour dietary recalls, and four qualitative food records. In...

  19. 77 FR 70781 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-11-27

    .... Compare the comprehensiveness of nursing home workplace violence prevention programs before and after... Prevention Program (C1). Nursing Home Administrators........ Committee Chair 7 1 1 Interview (C2). Nursing... days of this notice. Proposed Project Workplace Violence Prevention Programs in NJ...

  20. 76 FR 58515 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-09-21

    ... companies, health and social services, transportation, construction, agriculture, mining, skilled trade and... evaluations employees are interviewed to help further define concerns, and in approximately 50% these... the large number of investigations conducted each year, the need to respond quickly to requests for...

  1. 76 FR 22902 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-04-25

    ... deceased miner, ] including occupational history and smoking history. The data collected are used by... Surveillance Program (CWHSP)--OMB 0920-0020- Reinstatement With Change--National Institute for Occupational..., work in smaller mines, or are from certain geographic areas. Importantly, young coal miners...

  2. 75 FR 24706 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-05-05

    ... mandated CDC to establish autism surveillance and research programs to address the number, incidence... Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) including the... (CDC). Background and Brief Description This data collection is based on the following components...

  3. 76 FR 5377 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-01-31

    ... populations: College students, late adolescents (ages 15-18) and early adolescents (ages 11- 14). Sound... of 8-10 participants: 1 with prevention educators, 8 with college students, 8 with late adolescents (ages 15-18) and 8 with early adolescents (ages 11-14). Samples of college students and adolescents...

  4. 76 FR 74067 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-11-30

    ... need for educational messages and materials for adolescents, young adults, adults, and older adults...: adolescents aged 15-17, young adults aged 18-25, adults aged 26-35, and older adults 36 and over. To reach more rural participants, two telephone focus groups will be conducted: one with female adolescents...

  5. 78 FR 27391 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-05-10

    ... goal, CDC aims to address the need for educational messages and materials for adolescents, young adults... each target audience: adolescents aged 15-17, young adults aged 18-25, adults aged 26-35, and older... with female adolescents aged 15-17 and a second with male older adults aged 36 and older. The...

  6. 75 FR 43985 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-07-27

    ... Hispanic Adolescents--New-- National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP... intervention designed to prevent drug use and unsafe sex among Hispanic adolescents. Compared to non-Hispanic whites, Hispanic adolescents are highly vulnerable to acquiring HIV. Hispanic adolescents between...

  7. 75 FR 57960 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-09-23

    ... appropriateness of the program with urban, high-risk adolescents is unknown. CDC has learned additional information about violence and risk factors for adolescents in urban, high-risk communities since the original OMB clearance package was submitted. Recent research also has shown that adolescents who live in...

  8. 75 FR 9223 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-03-01

    ... increasing absenteeism among students or staff that impacted at least 824,966 students and 53,217 teachers... including the number of students and teachers impacted by the outbreak. Illness among school-aged students... of students and teachers impacted by the school dismissals. CDC will use the summary data to fully...

  9. 78 FR 18598 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-03-27

    ... beginning of H1N1 influenza pandemic, illness among school-aged students (K-12) in many states and cities resulted in at least 1,351 school dismissals due to rapidly increasing absenteeism among students or staff. These dismissals impacted at least 824,966 students and 53,217 teachers. During that time, the U.S...

  10. 75 FR 14163 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-03-24

    ... dismissals nationwide including the number of students and teachers impacted by the outbreak. Illness among school-aged students (K-12) in many States and cities resulted in at least 1351 school dismissals due to rapidly increasing absenteeism among students or staff that impacted at least 824,966 students and 53,217...

  11. 77 FR 73470 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-12-10

    ..., and treatment of congenital syphilis cases. Continued data collection will assist in identifying needs... required because treponemal IgM technologies, for the purpose of identifying CS in an infant, are...

  12. 77 FR 47074 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-08-07

    ... (NEISS-Work). The second data source, for which NIOSH is seeking OMB approval for a two year extension... questions about their occupational injury and related circumstances. However, in order to obtain enough data... original sample projection of 175 EMS workers. Consequently, the burden has been reduced as well....

  13. 78 FR 15366 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-03-11

    ... of U.S. carbon nanotube (CNT) and carbon nanofiber (CNF) workers. At present, because of the newness...) Industrywide exposure assessment study to evaluate worker exposure and further develop and refine measurement.... There is no cost to respondents or their employers other than their time. We estimate that the...

  14. 76 FR 60499 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-09-29

    ... evaluation, quantitative social media concept testing, and validation of advertisements and Surgeon General... online focus groups, primarily for social media concept testing. The estimated burden per response is 1-1... testing. The total estimated annualized burden for short surveys is 1,334 hours. (4) Medium-length...

  15. 76 FR 76415 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-12-07

    ... refugees, immigrants, migrants, international travelers, travel industry partners, healthcare providers... among immigrants, refugees, travelers, expatriates, and other globally mobile populations, and...

  16. 77 FR 66468 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-11-05

    ... foreign-born, migrant, refugee and other mobile populations with current or future ties to the United... outcomes among foreign-born, migrant, refugee and other mobile populations with current or future ties to... other health outcomes among foreign-born, migrant, refugee and other mobile populations with current...

  17. 75 FR 69086 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2010-11-10

    ... connection between ALS and other motor neuron disorders that can be confused with ALS, misdiagnosed as ALS... (Attachment 3) and assist with abstracting records as requested. An ALS Medical Record Verification Form...

  18. 77 FR 40360 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-07-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND... agents in order to protect the public health. The regulations also require conveyances to immediately... a number of forms--the Air Travel Illness or Death Investigation Form, Maritime Conveyance...

  19. 78 FR 45201 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2013-07-26

    ... knowledge of and attitudes toward colorectal cancer, history of colorectal cancer screening and intentions... the CRCCP in improving proximal outcomes (e.g., provider knowledge, population attitudes) and in..., Office of the Associate Director for Science, Office of the Director, Centers for Disease Control...

  20. Effectiveness of Manual Therapy and Stretching for Baseball Players With Shoulder Range of Motion Deficits.

    Science.gov (United States)

    Bailey, Lane B; Thigpen, Charles A; Hawkins, Richard J; Beattie, Paul F; Shanley, Ellen

    Baseball players displaying deficits in shoulder range of motion (ROM) are at increased risk of arm injury. Currently, there is a lack of consensus regarding the best available treatment options to restore shoulder ROM. Instrumented manual therapy with self-stretching will result in clinically significant deficit reductions when compared with self-stretching alone. Controlled laboratory study. Shoulder ROM and humeral torsion were assessed in 60 active baseball players (mean age, 19 ± 2 years) with ROM deficits (nondominant - dominant, ≥15°). Athletes were randomly assigned to receive a single treatment of instrumented manual therapy plus self-stretching (n = 30) or self-stretching only (n = 30). Deficits in internal rotation, horizontal adduction, and total arc of motion were compared between groups immediately before and after a single treatment session. Treatment effectiveness was determined by mean comparison data, and a number-needed-to-treat (NNT) analysis was used for assessing the presence of ROM risk factors. Prior to intervention, players displayed significant ( P stretching group displaying greater increases in internal rotation (+5°, P = 0.010), total arc of motion (+6°, P = 0.010), and horizontal adduction (+7°, P = 0.004) compared with self-stretching alone. For horizontal adduction deficits, the added use of instrumented manual therapy with self-stretching decreased the NNT to 2.2 (95% CI, 2.1-2.4; P = 0.010). Instrumented manual therapy with self-stretching significantly reduces ROM risk factors in baseball players with motion deficits when compared with stretching alone. The added benefits of manual therapy may help to reduce ROM deficits in clinical scenarios where stretching alone is ineffective.

  1. Analysis of Budget deficit in Romania during 2000-2013

    OpenAIRE

    2014-01-01

    Worldwide, over time, the years of economic crisis were defined by significant increases in the levels of budget deficits. Discussions on sizing budget deficits, financing, especially the volume of public debt became more intense, both politically and academically. The impact of budget deficit on economic growth is a common theme found in the economic policies adopted. The present paper aims to analyze the evolution of budget deficit and the structural budget deficit in Romania during 2000-20...

  2. MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users.

    Science.gov (United States)

    Parrott, Andrew C

    2013-09-01

    Serotonergic neurotoxicity following MDMA is well-established in laboratory animals, and neuroimaging studies have found lower serotonin transporter (SERT) binding in abstinent Ecstasy/MDMA users. Serotonin is a modulator for many different psychobiological functions, and this review will summarize the evidence for equivalent functional deficits in recreational users. Declarative memory, prospective memory, and higher cognitive skills are often impaired. Neurocognitive deficits are associated with reduced SERT in the hippocampus, parietal cortex, and prefrontal cortex. EEG and ERP studies have shown localised reductions in brain activity during neurocognitive performance. Deficits in sleep, mood, vision, pain, psychomotor skill, tremor, neurohormonal activity, and psychiatric status, have also been demonstrated. The children of mothers who take Ecstasy/MDMA during pregnancy have developmental problems. These psychobiological deficits are wide-ranging, and occur in functions known to be modulated by serotonin. They are often related to lifetime dosage, with light users showing slight changes, and heavy users displaying more pronounced problems. In summary, abstinent Ecstasy/MDMA users can show deficits in a wide range of biobehavioral functions with a serotonergic component.

  3. Multiple Deficits in ADHD: Executive Dysfunction, Delay Aversion, Reaction Time Variability, and Emotional Deficits

    Science.gov (United States)

    Sjowall, Douglas; Roth, Linda; Lindqvist, Sofia; Thorell, Lisa B.

    2013-01-01

    Background: The notion that ADHD constitutes a heterogeneous disorder is well accepted. However, this study contributes with new important knowledge by examining independent effects of a large range of neuropsychological deficits. In addition, the study investigated whether deficits in emotional functioning constitute a dissociable component of…

  4. Story Comprehension and Academic Deficits in Children with Attention Deficit Hyperactivity Disorder: What Is the Connection?

    Science.gov (United States)

    Berthiaume, Kristen S.

    2006-01-01

    Based on the reliable findings that children with attention deficit hyperactivity disorder (ADHD) have both attentional and academic difficulties, it is assumed that the attentional deficit contributes to the academic problems. In this article, existing support for a link between the attentional and academic difficulties experienced by children…

  5. Oculomotor Performance Identifies Underlying Cognitive Deficits in Attention-Deficit/Hyperactivity Disorder

    Science.gov (United States)

    Loe, Irene M.; Feldman, Heidi M.; Yasui, Enami; Luna, Beatriz

    2009-01-01

    The evaluation of the cognitive control in children with attention-deficit hyperactivity disorder through the use of oculomotor tests reveal that this group showed susceptibility to peripheral distractors and deficits in response inhibition. All subjects were found to have intact sensorimotor function and working memory.

  6. Readings on Attention Deficit Disorder or Attention Deficit/Hyperactivity Disorder. ERIC Mini-Bib.

    Science.gov (United States)

    Sorenson, Barbara, Comp.

    This annotated bibliography identifies 17 readings, 3 videotapes, and 8 children's books concerned with attention deficit disorder or attention deficit/hyperactivity disorder. Items include guides for parents, teachers, and students; analyses of issues in the field; practical teaching guides; investigations into etiology; and resource guides.…

  7. VARIACIÓN DEL CONTENIDO DE AZÚCARES TOTALES Y AZÚCARES REDUCTORES EN EL MUSGO Pleurozium schreberi (HYLOCOMIACEAE BAJO CONDICIONES DE DÉFICIT HÍDRICO Variation in Total Sugars and Reductive Sugars in the Moss Pleurozium schreberi (HYLOCOMIACEAE Under Water Deficit Conditions

    Directory of Open Access Journals (Sweden)

    LUIS CARLOS MONTENEGRO RUIZ

    2012-12-01

    Full Text Available Los briófitos por su simplicidad estructural se ven expuestos a estrés hídrico con facilidad, por lo que presentan mecanismos fisiológicos y bioquímicos que les permita sobrevivir. En el presente trabajo se evaluó la variación del contenido de azúcares totales solubles y azúcares reductores en relación con el contenido hídrico relativo, en Pleurozium schreberi cuando se enfrenta a contenidos hídricos bajos en el Páramo de Chingaza (Colombia y bajo condiciones simuladas de déficit hídrico en laboratorio. Se encontró que los azúcares totales aumentan cuando la planta se deshidrata y vuelve a su contenido normal cuando el musgo se rehidra, esto puede ser interpretado como un posible mecanismo de ajuste osmótico de la célula y osmoprotección del contenido celular y de la estructura celular. Los azúcares reductores no presentaron variación significativa, mostrando que los monosacáridos no tienen una función protectora durante la deshidratación.The structural simplicity of the bryophytes exposed them easily to water stress, forcing them to have physiological and biochemical mechanisms that enable them to survive. This study evaluated the variation of total soluble sugars and reducing sugars in relation to relative water content, in Pleurozium schreberi when faced with low water content in the Páramo de Chingaza (Colombia and under simulated conditions of water deficit in the laboratory. We found that total sugars increase when the plant is dehydrated and returned to their normal content when re-hydrated moss, this could be interpreted as a possible mechanism of osmotic adjustment and osmoprotection of the cell content and cellular structure. Reducing sugars showed no significant variation, showing that monosaccharides do not have a protective role during dehydration.

  8. THE IMPLICATIONS OF GROSS FIXED CAPITAL AND UNEMPLOYMENT RATE ON GENERAL GOVERNMENT DEFICIT. EMPIRICAL STUDY AT THE EUROPEAN LEVEL

    Directory of Open Access Journals (Sweden)

    Mihai Carp

    2010-12-01

    Full Text Available In this paper we have evaluated the influence of the modification of public investment level and unemployment rate on the general government deficit at the European Union level. We have created a regression model that shows that a sustained and increased investment policy and the reduction of unemployment rate have a favorable effect on the objective of minimizing the budget deficit. In the last years European Union’s countries had to face a difficult problem concerning fiscal policy. They had to make public investments to stimulate economic growth and, in the same time, they had to meet the convergence criteria’s of public deficit. On the other hand, EU has to deal with a higher rate of unemployment. Through our model we try to see how European Union countries should implement their political strategies on unemployment and investment with the main objective of reducing the general government deficit.

  9. Deficits in agency in schizophrenia, and additional deficits in body image, body schema and internal timing, in passivity symptoms.

    Directory of Open Access Journals (Sweden)

    Kyran Trent Graham

    2014-09-01

    Full Text Available Individuals with schizophrenia, particularly those with passivity symptoms, may not feel in control of their actions, believing them to be controlled by external agents. Cognitive operations that contribute to these symptoms may include abnormal processing in agency, as well as body representations that deal with body schema and body image. However, these operations in schizophrenia are not fully understood, and the questions of general versus specific deficits in individuals with different symptom profiles remain unanswered. Using the projected hand illusion (a digital video version of the rubber hand illusion with syn-chronous and asynchronous stroking (500 ms delay, and a hand laterality judgment task, we assessed sense of agency, body image and body schema in 53 people with clinically stable schizophrenia (with a current, past, and no history of passivity symptoms and 48 healthy controls. The results revealed a stable trait in schizophrenia with no difference be-tween clinical subgroups (sense of agency, and some quantitative (specific differences de-pending on the passivity symptom profile (body image and body schema. Specifically, a reduced sense of self-agency was a common feature of all clinical subgroups. However, subgroup comparisons showed that individuals with passivity symptoms (both current and past had significantly greater deficits on tasks assessing body image and body schema, relative to the other groups. In addition, patients with current passivity symptoms failed to demonstrate the normal reduction in body illusion typically seen with a 500 ms delay in visual feedback (asynchronous condition, suggesting internal timing problems. Altogether, the results underscore self-abnormalities in schizophrenia, provide evidence for both trait abnormalities and state changes specific to passivity symptoms, and point to a role for internal timing deficits as a mechanistic explanation for external cues becoming a possible source of self

  10. Experimental 'jet lag' inhibits adult neurogenesis and produces long-term cognitive deficits in female hamsters.

    Directory of Open Access Journals (Sweden)

    Erin M Gibson

    Full Text Available BACKGROUND: Circadian disruptions through frequent transmeridian travel, rotating shift work, and poor sleep hygiene are associated with an array of physical and mental health maladies, including marked deficits in human cognitive function. Despite anecdotal and correlational reports suggesting a negative impact of circadian disruptions on brain function, this possibility has not been experimentally examined. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we investigated whether experimental 'jet lag' (i.e., phase advances of the light:dark cycle negatively impacts learning and memory and whether any deficits observed are associated with reductions in hippocampal cell proliferation and neurogenesis. Because insults to circadian timing alter circulating glucocorticoid and sex steroid concentrations, both of which influence neurogenesis and learning/memory, we assessed the contribution of these endocrine factors to any observed alterations. Circadian disruption resulted in pronounced deficits in learning and memory paralleled by marked reductions in hippocampal cell proliferation and neurogenesis. Significantly, deficits in hippocampal-dependent learning and memory were not only seen during the period of the circadian disruption, but also persisted well after the cessation of jet lag, suggesting long-lasting negative consequences on brain function. CONCLUSIONS/SIGNIFICANCE: Together, these findings support the view that circadian disruptions suppress hippocampal neurogenesis via a glucocorticoid-independent mechanism, imposing pronounced and persistent impairments on learning and memory.

  11. Effect of water deficit stress on yield, physiological and biochemical parameters of two Iranian cantaloupe accessions

    Directory of Open Access Journals (Sweden)

    Hadi Lotfi

    2016-06-01

    Full Text Available Water deficit stress is one of the most important environmental factors limitting plant growth and crop production. In order to evaluate the tolerance of two Iranian melons to water deficit stress, an experiment in research filed of University of Zanjan was conducted. Treatments consisted of three Irrigation levels, starting irrigation at (100, 66 and 33 % Crop Evapotranspiration and two accessions of Iranian cantaloupes (Tile-Zard and Tile-Sabz. In this experiment, total chlorophyll content, carotenoids, proline content, leaf relative water content (RWC, ascorbic acid, peroxidase and catalase activity, yield and water use efficiency (WUE were evaluated. The results indicated that water deficit stress significantly increased proline content, peroxidase and catalase activity and WUE, but decreased RWC, yield and total chlorophyll content. The highest increase in proline content (34.8 %, catalase (18 % and proxidase (42.3 % activity and reduction in yield (61.6 % and RWC (8 % was obtained in 33 % ETc Irrigation. There has been significant difference between accesesions in relation to RWC, proline, total chlorophyll and peroxidase and catalase activity. The highest value of yield and WUE was observed in 'Tile-Zard'. According to the interaction results, both accessions, 'Tile-Sabz' and 'Tile-Zard' with 63.6 % and 59.7 % Reduction in fruit yield under deficit water stress, are.

  12. Test Differences in Diagnosing Reading Comprehension Deficits

    Science.gov (United States)

    Keenan, Janice M.; Meenan, Chelsea E.

    2012-01-01

    We examined the implications of test differences for defining and diagnosing comprehension deficits using reading comprehension tests. We had 995 children complete the Gray Oral Reading Test-3, the Qualitative Reading Inventory-3, the Woodcock-Johnson Passage Comprehension-3, and the Peabody Individual Achievement Test, and compared which children were identified by each test as being in the lowest 10%. Although a child who performs so poorly might be expected to do poorly on all tests, we found that the average overlap between tests in diagnosing comprehension difficulties was only 43%. Consistency in diagnosis was greater for younger children, when comprehension deficits are due to weaker decoding skills, than for older children. Inconsistencies between tests were just as evident when identifying the top performers. The different children identified as having a comprehension deficit by each test were compared on four profile variables - word decoding skill, IQ, ADHD symptoms, and working memory skill – to understand the nature of the different deficits assessed by each test. Theoretical and practical implications of these test differences in defining and diagnosing comprehension deficits are discussed. PMID:22442251

  13. Social-Cognitive Deficits in Schizophrenia.

    Science.gov (United States)

    Mier, Daniela; Kirsch, Peter

    Patients with schizophrenia not only suffer from prototypical psychotic symptoms such as delusions and hallucinations and from cognitive deficits, but also from tremendous deficits in social functioning. However, little is known about the interplay between the cognitive and the social-cognitive deficits in schizophrenia. Our chapter gives an overview on behavioral, as well as functional imaging studies on social cognition in schizophrenia. Main findings on cognitive and motivational deficits in schizophrenia are reviewed and introduced within the context of the dopamine hypothesis of schizophrenia. The reviewed findings suggest that disturbed "social brain" functioning in schizophrenia, depending on the specific context, can either lead to a neglect of the emotions and intentions of others or to the false attribution of these emotions and intentions in an emotionally neutral social content. We integrate these findings with the current knowledge about aberrant dopaminergic firing in schizophrenia by presenting a comprehensive model explaining core symptoms of the disorder. The main implication of the presented model is that neither cognitive-motivational, nor social-cognitive deficits alone cause schizophrenia symptoms, but that symptoms only emerge by the interplay of disturbed social brain functioning with aberrant dopaminergic firing.

  14. Neuropsychological deficits in patients with Lyme borreliosis

    Directory of Open Access Journals (Sweden)

    Katja Pruša

    2001-09-01

    Full Text Available Slovenia is an endemic area for Lyme borreliosis, a disease that affects many organic systems. Decline in cognitive abilities and emotional changes can appear in acute and chronic stage of the disease beside somatic difficulties. Early antibiotic therapy is of great importance in recovery. Attention and concentration deficits, memory deficits, impaired executive functioning, depression and other symptoms reduce work efficiency and life quality of people with Lyme borreliosis. Neuropsychological deficits can be explained with central nervous system impairment and partly also with reactive psychological factors. On account of symptomatic complexity, broad differential diagnostic and unreliable diagnostic technology neuropsychological evaluation can help to correctly diagnose and accurately treat this disease, and thus to enable appropriate cognitive rehabilitation and psychotherapeutic assistance.

  15. Autism: Why Act Early?

    Science.gov (United States)

    ... What's this? Submit Button Past Emails CDC Features Autism: Why Act Early? Language: English Español (Spanish) Recommend ... helped the world make sense." Florida teenager with Autism Spectrum Disorder "Because my parents acted early, I ...

  16. Consequences of the Budget Deficit in the Current Crisis in Romania. Implications on the Labor Market

    Directory of Open Access Journals (Sweden)

    Gabriela MOLĂNESCU

    2011-02-01

    Full Text Available In the current economic activity conditions, in which the need of financial resources is usually higher than the existing funds, the elaborations of budgets at any level is one of the primary issues, particularly as regards the principle of budgetary balance. Approaches regarding sizing budgets deficits, means of financing and particularly sizing public debt get a series of touches of precise nature for different economies. Actual economic, financial, social and administrative conditions put up a series of problems which impose an extremely serious approach of the potential adverse impact by sizing of budget deficits and public debt over the real possibilities of noninflationary financing. In Romania, in the highly complex framework in which the economic activity takes place, in the attempt to show the place held by the budget deficit, a special role is assigned to determine the share of public financial deficit in the consolidated budget revenue and expenditure. Currently, knowledge and concern for reducing the budget deficit are still of great importance, especially as Romania is facing great difficulties in economic development. Amid deepening structural crisis phenomena, increasing budget deficits financed over a non-inflationary limits comes as an additional factor that contributes to imbalances of the economy. In addition, where budgetary expenditures are targeted to satisfy, primary, the redistribution function and to state subsidies, because of the lack of a real multiplier coefficient, the state budget deficit worsens. Influences such as introducing economic disturbance in the mechanisms which cause them to increase budget deficits can be summarized and grouped into two broad categories: economic influences and psychological influences. Regarding economic influences, we can say that they act strongly and strictly determined by how meanings used to cover budget deficit. The modalities used are subject to an analysis by direct or indirect

  17. Timing deficits in attention-deficit/hyperactivity disorder (ADHD): evidence from neurocognitive and neuroimaging studies.

    Science.gov (United States)

    Noreika, Valdas; Falter, Christine M; Rubia, Katya

    2013-01-01

    Relatively recently, neurocognitive and neuroimaging studies have indicated that individuals with attention-deficit/hyperactivity disorder (ADHD) may have deficits in a range of timing functions and their underlying neural networks. Despite this evidence, timing deficits in ADHD are still somewhat neglected in the literature and mostly omitted from reviews on ADHD. There is therefore a lack of integrative reviews on the up-to-date evidence on neurocognitive and neurofunctional deficits of timing in ADHD and their significance with respect to other behavioural and cognitive deficits. The present review provides a synthetic overview of the evidence for neurocognitive and neurofunctional deficits in ADHD in timing functions, and integrates this evidence with the cognitive neuroscience literature of the neural substrates of timing. The review demonstrates that ADHD patients are consistently impaired in three major timing domains, in motor timing, perceptual timing and temporal foresight, comprising several timeframes spanning milliseconds, seconds, minutes and longer intervals up to years. The most consistent impairments in ADHD are found in sensorimotor synchronisation, duration discrimination, reproduction and delay discounting. These neurocognitive findings of timing deficits in ADHD are furthermore supported by functional neuroimaging studies that show dysfunctions in the key inferior fronto-striato-cerebellar and fronto-parietal networks that mediate the timing functions. Although there is evidence that these timing functions are inter-correlated with other executive functions that are well established to be impaired in the disorder, in particular working memory, attention, and to a lesser degree inhibitory control, the key timing deficits appear to survive when these functions are controlled for, suggesting independent cognitive deficits in the temporal domain. There is furthermore strong evidence for an association between timing deficits and behavioural

  18. The dermatology acting internship.

    Science.gov (United States)

    Stephens, John B; Raimer, Sharon S; Wagner, Richard F

    2011-07-15

    Acting internships are an important component of modern day medical school curriculum. Several specialties outside of internal medicine now offer acting internship experiences to fourth year medical students. We have found that a dermatology acting internship is a valuable experience for fourth year medical students who are interested in pursuing a residency in dermatology. Our experience with the dermatology acting internship over the 2010-2011 academic year is described.

  19. Guanfacine Extended Release in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Placebo-Controlled Trial

    Science.gov (United States)

    Sallee, Floyd R.; McGough, James; Wigal, Tim; Donahue, Jessica; Lyne, Andrew; Biederman, Joseph

    2009-01-01

    A double-blind, 9-week, randomized trial was done to compare the efficacy of guanfacine extended release (GXR) with a placebo in treating children and adolescents with attention-deficit/hyperactivity disorders (ADHD). Results find a significant reduction in ADHD from baseline to endpoint for all daily doses of GXR which were measured at 1-, 2-,…

  20. EEG markers of reduced visual short-term memory capacity in adult attention deficit/hyperactivity disorder

    DEFF Research Database (Denmark)

    Wiegand, Iris Michaela; Kilian, Beate; Hennig-Fast, Kristina

    2015-01-01

    Attention deficit hyperactivity disorder (ADHD) persists frequently into adulthood. The disease is associated with difficulties in many cognitive tasks, which are assumed to be caused by neurobiologically-based basal dysfunctions. A reduction in visual working memory storage capacity has recently...

  1. Conversion to Parkinson Disease in the PARS Hyposmic and Dopamine Transporter-Deficit Prodromal Cohort.

    Science.gov (United States)

    Jennings, Danna; Siderowf, Andrew; Stern, Matthew; Seibyl, John; Eberly, Shirley; Oakes, David; Marek, Kenneth

    2017-08-01

    no DAT deficit, respectively (P = .002). The relative risk of conversion to a diagnosis of PD in hyposmic individuals with a DAT deficit was 17.47 (95% CI, 7.02-43.45) compared with individuals with either indeterminate or no DAT deficit. The combination of hyposmia and DAT deficit was highly predictive of conversion to PD within 4 years of clinical follow-up. Individuals with hyposmia and a DAT deficit had a 5% reduction in DAT binding annually, similar to early PD. These results provide a framework for planning disease prevention studies in PD.

  2. Indirect Speech Acts

    Institute of Scientific and Technical Information of China (English)

    李威

    2001-01-01

    Indirect speech acts are frequently used in verbal communication, the interpretation of them is of great importance in order to meet the demands of the development of students' communicative competence. This paper, therefore, intends to present Searle' s indirect speech acts and explore the way how indirect speech acts are interpreted in accordance with two influential theories. It consists of four parts. Part one gives a general introduction to the notion of speech acts theory. Part two makes an elaboration upon the conception of indirect speech act theory proposed by Searle and his supplement and development of illocutionary acts. Part three deals with the interpretation of indirect speech acts. Part four draws implication from the previous study and also serves as the conclusion of the dissertation.

  3. 76 FR 22611 - Privacy Act of 1974; Implementation

    Science.gov (United States)

    2011-04-22

    ... remove and reserve 321.13(h). This will improve the efficiency and effectiveness of DoD's program by... no additional information collection requirements on the public under the Paperwork Reduction Act of...

  4. Lymphedema Risk Reduction Practices

    Science.gov (United States)

    ... now! Position Paper: Lymphedema Risk Reduction Practices Category: Position Papers Tags: Risks Archives Treatment risk reduction garments surgery obesity infection blood pressure trauma morbid obesity body weight ...

  5. A review of executive function deficits and pharmacological management in children and adolescents.

    Science.gov (United States)

    Hosenbocus, Sheik; Chahal, Raj

    2012-08-01

    To review both the functions and dysfunction of the executive system (ES) focusing on the extent of executive function (EF) deficits in most psychiatric disorders in children and adolescents and the possibility of such deficits acting as markers for pharmacological management. A LITERATURE REVIEW WAS CONDUCTED USING MEDLINE, PSYCHINFO, CINAHL, PSYCHARTICLES AND PUBMED WITH THE FOLLOWING KEYWORDS: executive function or dysfunction, pediatric or children or adolescents, psychopharmacology, psychotropic medications, attention deficit hyperactivity disorder (ADHD), depression, obsessive compulsive disorder, anxiety disorders, bipolar disorder, schizophrenia, autism spectrum disorders (ASD), fetal alcohol spectrum disorders (FASD). Due to the limited amount of specific information obtained for some childhood disorders, the search was broadened to include relevant adult literature where information was extrapolated. Abundant literature was found on the nature of the ES and the executive dysfunctions in most psychiatric disorders in children and adolescents, but not so much on the use of medication. EF deficits were found to be more consistent in disorders such as ADHD, ASD and FASD than in the other disorders but were not specific enough for use as clinical markers for those disorders. For children with ADHD and ASD there was adequate information on the use of psychotropic medications and impact on some EF domains but information on the impact of medication on EF in the other disorders in children and adolescents was fairly limited. Medications acting on the dopaminergic system also showed positive effects on EF deficits and are commonly used in the treatment of EF disorders such as ADHD, ASD and FASD. Existing literature indicates that EF deficits underlie most psychiatric disorders in children and adolescents. However, there are so many executive functions linked to so many activities and circuits in the brain that it is hard to quantify them in a particular disorder

  6. Park power deficit due to atmospheric stability

    DEFF Research Database (Denmark)

    Hansen, Kurt Schaldemose; Barthelmie, Rebecca; Ott, Søren

    The purpose of this paper is to present a power deficit analysis based on offshore wind farm measurements with respect to the atmospheric stability classification. The result is used to validate wind farm prediction models under different inflow and atmospheric stability conditions...

  7. Medication Treatment for Attention Deficit Hyperactivity Disorder

    Science.gov (United States)

    Ryan, Joseph B.; Katsiyannis, Antonis; Hughes, Elizabeth M.

    2011-01-01

    Attention deficit hyperactivity disorder (ADHD) has become the most commonly diagnosed psychiatric disorder among school-age children. For more than half a century, physicians have prescribed medications to help manage behaviors such as hyperactivity, impulsivity, and inattention. Today, there is a growing consensus that ADHD is a biologically…

  8. Working together in a deficit logic

    DEFF Research Database (Denmark)

    Matthiesen, Noomi Christine Linde

    2016-01-01

    and with parents in home–school communication. It is argued that in a society with increased focus on parental responsibility the teachers and principals draw on a deficit logic when dealing with Somali diaspora parents and children which consequently leads to teachers either transmitting their expertise...

  9. Supply Deficit of m-Aminophenol

    Institute of Scientific and Technical Information of China (English)

    Wang Zaijun

    2007-01-01

    @@ Supply deficit in the domestic market China's capacity to produce maminophenol was 2.3 thousand t/a and the actual output was around 1.8 thousand tons in 2006. Most producers use the nitrobenzene sulfonation alkali-fusion process developed by Shenyang Research Institute of Chemical Industry.

  10. Detection of feigned attention deficit hyperactivity disorder

    NARCIS (Netherlands)

    Tucha, Lara; Fuermaier, Anselm B.M.; Koerts, Janneke; Groen, Yvonne; Thome, Johannes

    2015-01-01

    In recent years, there is an increasing awareness that individuals may purposely feign or exaggerate symptoms of attention deficit hyperactivity disorder (ADHD) to gain external incentives, including access to stimulant drugs or special academic accommodations. There are vast consequences of undetec

  11. Stigma in attention deficit hyperactivity disorder

    NARCIS (Netherlands)

    Müller, Kathi; Fuermaier, Anselm B M; Koerts, Janneke; Tucha, Lara

    Attention deficit hyperactivity disorder (ADHD) is a frequently diagnosed disorder in child- and adulthood with a high impact affecting multiple facets of social life. Therefore, patients suffering from ADHD are at high risk to be confronted with stigma, prejudices, and discrimination. A review of

  12. Frequency of Cognitive Deficits in Neurofibromatosis

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2005-11-01

    Full Text Available The frequency and severity of specific cognitive deficits in 81 children with neurofibromatosis type 1 (NF1, ages 8 to 16 years, compared to 49 unaffected sibling controls, were assessed in a study at the University of Sydney, New South Wales, Australia.

  13. Linguistic coding deficits in foreign language learners.

    Science.gov (United States)

    Sparks, R; Ganschow, L; Pohlman, J

    1989-01-01

    As increasing numbers of colleges and universities require a foreign language for graduation in at least one of their degree programs, reports of students with difficulties in learning a second language are multiplying. Until recently, little research has been conducted to identify the nature of this problem. Recent attempts by the authors have focused upon subtle but ongoing language difficulties in these individuals as the source of their struggle to learn a foreign language. The present paper attempts to expand upon this concept by outlining a theoretical framework based upon a linguistic coding model that hypothesizes deficits in the processing of phonological, syntactic, and/or semantic information. Traditional psychoeducational assessment batteries of standardized intelligence and achievement tests generally are not sensitive to these linguistic coding deficits unless closely analyzed or, more often, used in conjunction with a more comprehensive language assessment battery. Students who have been waived from a foreign language requirement and their proposed type(s) of linguistic coding deficits are profiled. Tentative conclusions about the nature of these foreign language learning deficits are presented along with specific suggestions for tests to be used in psychoeducational evaluations.

  14. Color Vision Deficits and Literacy Acquisition.

    Science.gov (United States)

    Hurley, Sandra Rollins

    1994-01-01

    Shows that color blindness, whether partial or total, inhibits literacy acquisition. Offers a case study of a third grader with impaired color vision. Presents a review of literature on the topic. Notes that people with color vision deficits are often unaware of the handicap. (RS)

  15. RAN and Double-Deficit Theory

    Science.gov (United States)

    Cronin, Virginia S.

    2013-01-01

    Lervag and Hulme’s neuro-developmental theory and Wolf and Bowers’s double-deficit hypothesis were examined in this longitudinal study. A total of 130 children were tested in preschool and followed through fifth grade, when 84 remained in the study. During preschool and kindergarten the participants were given tests of end-sound discrimination…

  16. Rethinking a Right Hemisphere Deficit in ADHD

    Science.gov (United States)

    Hale, T. Sigi; Loo, Sandra K.; Zaidel, Eran; Hanada, Grant; Macion, James; Smalley, Susan L.

    2009-01-01

    Introduction: Early observations from lesion studies suggested right hemisphere (RH) dysfunction in ADHD. However, a strictly right-lateralized deficit has not been well supported. An alternatively view suggests increased R greater than L asymmetry of brain function and abnormal interhemispheric interaction. If true, RH pathology in ADHD should…

  17. Exploring Dyslexics' Phonological Deficit II: Phonological Grammar

    Science.gov (United States)

    Szenkovits, Gayaneh; Darma, Quynliaan; Darcy, Isabelle; Ramus, Franck

    2016-01-01

    Language learners have to acquire the phonological grammar of their native language, and different levels of representations on which the grammar operates. Developmental dyslexia is associated with a phonological deficit, which is commonly assumed to stem from degraded phonological representations. The present study investigates one aspect of the…

  18. Medication Treatment for Attention Deficit Hyperactivity Disorder

    Science.gov (United States)

    Ryan, Joseph B.; Katsiyannis, Antonis; Hughes, Elizabeth M.

    2011-01-01

    Attention deficit hyperactivity disorder (ADHD) has become the most commonly diagnosed psychiatric disorder among school-age children. For more than half a century, physicians have prescribed medications to help manage behaviors such as hyperactivity, impulsivity, and inattention. Today, there is a growing consensus that ADHD is a biologically…

  19. Stigma in attention deficit hyperactivity disorder

    NARCIS (Netherlands)

    Müller, Kathi; Fuermaier, Anselm B M; Koerts, Janneke; Tucha, Lara

    2012-01-01

    Attention deficit hyperactivity disorder (ADHD) is a frequently diagnosed disorder in child- and adulthood with a high impact affecting multiple facets of social life. Therefore, patients suffering from ADHD are at high risk to be confronted with stigma, prejudices, and discrimination. A review of t

  20. Heterogeneity of Developmental Dyscalculia: Cases with Different Deficit Profiles.

    Science.gov (United States)

    Träff, Ulf; Olsson, Linda; Östergren, Rickard; Skagerlund, Kenny

    2016-01-01

    Developmental Dyscalculia (DD) has long been thought to be a monolithic learning disorder that can be attributed to a specific neurocognitive dysfunction. However, recent research has increasingly recognized the heterogeneity of DD, where DD can be differentiated into subtypes in which the underlying cognitive deficits and neural dysfunctions may differ. The aim was to further understand the heterogeneity of developmental dyscalculia (DD) from a cognitive psychological perspective. Utilizing four children (8-9 year-old) we administered a comprehensive cognitive test battery that shed light on the cognitive-behavioral profile of each child. The children were compared against norm groups of aged-matched peers. Performance was then contrasted against predominant hypotheses of DD, which would also give insight into candidate neurocognitive correlates. Despite showing similar mathematical deficits, these children showed remarkable interindividual variability regarding cognitive profile and deficits. Two cases were consistent with the approximate number system deficit account and also the general magnitude-processing deficit account. These cases showed indications of having domain-general deficits as well. One case had an access deficit in combination with a general cognitive deficit. One case suffered from general cognitive deficits only. The results showed that DD cannot be attributed to a single explanatory factor. These findings support a multiple deficits account of DD and suggest that some cases have multiple deficits, whereas other cases have a single deficit. We discuss a previously proposed distinction between primary DD and secondary DD, and suggest hypotheses of dysfunctional neurocognitive correlates responsible for the displayed deficits.

  1. Regulated deficit irrigation alters anthocyanins, tannins and sensory properties of cabernet sauvignon grapes and wines.

    Science.gov (United States)

    Casassa, Luis Federico; Keller, Markus; Harbertson, James F

    2015-04-29

    Four regulated deficit irrigation (RDI) regimes were applied to Cabernet Sauvignon grapes, which were analyzed for phenolics and also made into wine over three consecutive growing seasons. Relative to an industry standard regime (IS), yield was reduced over the three years by 37% in a full-deficit (FD) regime and by 18% in an early deficit (ED) regime, whereas no yield reduction occurred with a late deficit (LD) regime. Relative to IS, skin anthocyanin concentration (fresh weight basis) was 18% and 24% higher in ED and FD, respectively, whereas no effect was seen in LD. Seed tannin concentration was 3% and 8% higher in ED and FD, respectively, relative to the other two RDI regimes, whereas seed tannin content (amount per berry) was higher in IS than in FD. There were no practically relevant effects on the basic chemistry of the wines. The finished wines showed concentrations of tannins and anthocyanins that generally mirrored observed differences in skin and seed phenolic concentrations, although these were amplified in FD wines. Descriptive sensory analysis of the 2008 wines showed that FD wines were the most saturated in color, with higher purple hue, roughness, dryness and harshness, followed by ED wines, whereas IS and LD wines were less saturated in color and with higher brown and red hues. Overall, FD and ED seemed to yield fruit and wine with greater concentrations of phenolics than IS and LD, with the additional advantage of reducing water usage. However, these apparent benefits need to be balanced out with reductions in crop yields and potential long-term effects associated with pre-véraison water deficits.

  2. Regulated Deficit Irrigation Alters Anthocyanins, Tannins and Sensory Properties of Cabernet Sauvignon Grapes and Wines

    Directory of Open Access Journals (Sweden)

    Luis Federico Casassa

    2015-04-01

    Full Text Available Four regulated deficit irrigation (RDI regimes were applied to Cabernet Sauvignon grapes, which were analyzed for phenolics and also made into wine over three consecutive growing seasons. Relative to an industry standard regime (IS, yield was reduced over the three years by 37% in a full-deficit (FD regime and by 18% in an early deficit (ED regime, whereas no yield reduction occurred with a late deficit (LD regime. Relative to IS, skin anthocyanin concentration (fresh weight basis was 18% and 24% higher in ED and FD, respectively, whereas no effect was seen in LD. Seed tannin concentration was 3% and 8% higher in ED and FD, respectively, relative to the other two RDI regimes, whereas seed tannin content (amount per berry was higher in IS than in FD. There were no practically relevant effects on the basic chemistry of the wines. The finished wines showed concentrations of tannins and anthocyanins that generally mirrored observed differences in skin and seed phenolic concentrations, although these were amplified in FD wines. Descriptive sensory analysis of the 2008 wines showed that FD wines were the most saturated in color, with higher purple hue, roughness, dryness and harshness, followed by ED wines, whereas IS and LD wines were less saturated in color and with higher brown and red hues. Overall, FD and ED seemed to yield fruit and wine with greater concentrations of phenolics than IS and LD, with the additional advantage of reducing water usage. However, these apparent benefits need to be balanced out with reductions in crop yields and potential long-term effects associated with pre-véraison water deficits.

  3. Tall fescue endophyte effects on tolerance to water-deficit stress

    Science.gov (United States)

    2013-01-01

    Background The endophytic fungus, Neotyphodium coenophialum, can enhance drought tolerance of its host grass, tall fescue. To investigate endophyte effects on plant responses to acute water deficit stress, we did comprehensive profiling of plant metabolite levels in both shoot and root tissues of genetically identical clone pairs of tall fescue with endophyte (E+) and without endophyte (E-) in response to direct water deficit stress. The E- clones were generated by treating E+ plants with fungicide and selectively propagating single tillers. In time course studies on the E+ and E- clones, water was withheld from 0 to 5 days, during which levels of free sugars, sugar alcohols, and amino acids were determined, as were levels of some major fungal metabolites. Results After 2–3 days of withholding water, survival and tillering of re-watered plants was significantly greater for E+ than E- clones. Within two to three days of withholding water, significant endophyte effects on metabolites manifested as higher levels of free glucose, fructose, trehalose, sugar alcohols, proline and glutamic acid in shoots and roots. The fungal metabolites, mannitol and loline alkaloids, also significantly increased with water deficit. Conclusions Our results suggest that symbiotic N. coenophialum aids in survival and recovery of tall fescue plants from water deficit, and acts in part by inducing rapid accumulation of these compatible solutes soon after imposition of stress. PMID:24015904

  4. Response of early-peach [Prunus persica (L.)] trees to deficit irrigation

    Energy Technology Data Exchange (ETDEWEB)

    Abrisqueta, I.; Tapia, L. M.; Conejero, W.; Sanchez-Toribio, M. I.; Abrisqueta, J. M.; Vera, J.; Ruiz-Sanchez, C.

    2010-07-01

    The effect of different irrigation strategies in water relations, vegetative growth and yield of early maturing peach trees, growing in Murcia, (Spain) was studied during two years. Treatments consisted on: a control T1, full irrigated (150% of ETc); T2, continuous deficit irrigation at 50% of ETc; T3, regulated deficit irrigation (RDI), irrigated at 100% of ETc only during stage III of fruit growth and 25% the rest of the growing season; and T4, with automatic control of irrigation based on capacitance FDR-type probe data, varying threshold values. The results indicated that irrigation deficits in T2 and T3 treatments induced the lowest soil water content and stem water potential(?stem) values during the post harvest period (e.g {psi}{sub s}tem up to -1.8 MPa in T3 during summer 2008); thus, a reduction in trunk growth and pruning weight, respect to control treatment values, was noted in both years. Also, peach yield was significantly reduced in both deficit irrigated treatments. The greatest irrigation water saving in T3 treatment (=60%) caused the higher water use efficiency values in this treatment. For these reasons, water deficit during the post harvest periods (extended in the early maturing varieties) must be limited if fruit yield is not to be reduced. Irrigation scheduling based on capacitance probes have become a useful tool in the control of soil water content. When threshold values were precisely defined, the slight water deficits limited only vegetative growth while maintaining similar peach yield to that of well irrigated trees. (Author) 31 refs.

  5. Visual sensory processing deficits in patients with bipolar disorder revealed through high-density electrical mapping.

    LENUS (Irish Health Repository)

    Yeap, Sherlyn

    2009-11-01

    BACKGROUND: Etiological commonalities are apparent between bipolar disorder and schizophrenia. For example, it is becoming clear that both populations show similar electrophysiological deficits in the auditory domain. Recent studies have also shown robust visual sensory processing deficits in patients with schizophrenia using the event-related potential technique, but this has not been formally tested in those with bipolar disorder. Our goal here was to assess whether early visual sensory processing in patients with bipolar disorder, as indexed by decreased amplitude of the P1 component of the visual evoked potential (VEP), would show a similar deficit to that seen in those with schizophrenia. Since the P1 deficit has already been established as an endophenotype in schizophrenia, a finding of commonality between disorders would raise the possibility that it represents a measure of common genetic liability. METHODS: We visually presented isolated-check stimuli to euthymic patients with a diagnosis of bipolar disorder and age-matched healthy controls within a simple go\\/no-go task and recorded VEPs using high-density (72-channel) electroencephalography. RESULTS: The P1 VEP amplitude was substantially reduced in patients with bipolar disorder, with an effect size of f = 0.56 (large according to Cohen\\'s criteria). LIMITATIONS: Our sample size was relatively small and as such, did not allow for an examination of potential relations between the physiologic measures and clinical measures. CONCLUSION: This reduction in P1 amplitude among patients with bipolar disorder represents a dysfunction in early visual processing that is highly similar to that found repeatedly in patients with schizophrenia and their healthy first-degree relatives. Since the P1 deficit has been related to susceptibility genes for schizophrenia, our results raise the possibility that the deficit may in fact be more broadly related to the development of psychosis and that it merits further

  6. Robotic identification of kinesthetic deficits after stroke.

    Science.gov (United States)

    Semrau, Jennifer A; Herter, Troy M; Scott, Stephen H; Dukelow, Sean P

    2013-12-01

    Kinesthesia, the sense of body motion, is essential to proper control and execution of movement. Despite its importance for activities of daily living, no current clinical measures can objectively measure kinesthetic deficits. The goal of this study was to use robotic technology to quantify prevalence and severity of kinesthetic deficits of the upper limb poststroke. Seventy-four neurologically intact subjects and 113 subjects with stroke (62 left-affected, 51 right-affected) performed a robot-based kinesthetic matching task with vision occluded. The robot moved the most affected arm at a preset speed, direction, and magnitude. Subjects were instructed to mirror-match the movement with their opposite arm (active arm). A large number of subjects with stroke were significantly impaired on measures of kinesthesia. We observed impairments in ability to match movement direction (69% and 49% impaired for left- and right-affected subjects, respectively) and movement magnitude (42% and 31%). We observed impairments to match movement speed (32% and 27%) and increased response latencies (48% and 20%). Movement direction errors and response latencies were related to clinical measures of function, motor recovery, and dexterity. Using a robotic approach, we found that 61% of acute stroke survivors (n=69) had kinesthetic deficits. Additionally, these deficits were highly related to existing clinical measures, suggesting the importance of kinesthesia in day-to-day function. Our methods allow for more sensitive, accurate, and objective identification of kinesthetic deficits after stroke. With this information, we can better inform clinical treatment strategies to improve poststroke rehabilitative care and outcomes.

  7. Primary empathy deficits in frontotemporal dementia

    Directory of Open Access Journals (Sweden)

    Sandra eBaez

    2014-10-01

    Full Text Available Loss of empathy is an early central symptom and diagnostic criterion of the behavioral variant frontotemporal dementia (bvFTD. Although changes in empathy are evident and strongly affect the social functioning of bvFTD patients, few studies have directly investigated this issue by means of experimental paradigms. The current study assessed multiple components of empathy (affective, cognitive and moral in bvFTD patients. We also explored whether the loss of empathy constitutes a primary deficit of bvFTD or whether it is explained by impairments in executive functions (EF or other social cognition domains. Thirty-seven bvFTD patients with early/mild stages of the disease and 30 healthy control participants were assessed with a task that involves the perception of intentional and accidental harm. Participants were also evaluated on emotion recognition, theory of mind (ToM, social norms knowledge and several EF domains. BvFTD patients presented deficits in affective, cognitive and moral aspects of empathy. However, empathic concern was the only aspect primarily affected in bvFTD that was neither related nor explained by deficits in EF or other social cognition domains. Deficits in the cognitive and moral aspects of empathy seem to depend on EF, emotion recognition and ToM. Our findings highlight the importance of using tasks depicting real-life social scenarios because of their greater sensitivity in the assessment of bvFTD. Moreover, our results contribute to the understanding of primary and intrinsic empathy deficits of bvFTD and have important theoretical and clinical implications.

  8. Primary empathy deficits in frontotemporal dementia

    Science.gov (United States)

    Baez, Sandra; Manes, Facundo; Huepe, David; Torralva, Teresa; Fiorentino, Natalia; Richter, Fabian; Huepe-Artigas, Daniela; Ferrari, Jesica; Montañes, Patricia; Reyes, Pablo; Matallana, Diana; Vigliecca, Nora S.; Decety, Jean; Ibanez, Agustin

    2014-01-01

    Loss of empathy is an early central symptom and diagnostic criterion of the behavioral variant frontotemporal dementia (bvFTD). Although changes in empathy are evident and strongly affect the social functioning of bvFTD patients, few studies have directly investigated this issue by means of experimental paradigms. The current study assessed multiple components of empathy (affective, cognitive and moral) in bvFTD patients. We also explored whether the loss of empathy constitutes a primary deficit of bvFTD or whether it is explained by impairments in executive functions (EF) or other social cognition domains. Thirty-seven bvFTD patients with early/mild stages of the disease and 30 healthy control participants were assessed with a task that involves the perception of intentional and accidental harm. Participants were also evaluated on emotion recognition, theory of mind (ToM), social norms knowledge and several EF domains. BvFTD patients presented deficits in affective, cognitive and moral aspects of empathy. However, empathic concern was the only aspect primarily affected in bvFTD that was neither related nor explained by deficits in EF or other social cognition domains. Deficits in the cognitive and moral aspects of empathy seem to depend on EF, emotion recognition and ToM. Our findings highlight the importance of using tasks depicting real-life social scenarios because of their greater sensitivity in the assessment of bvFTD. Moreover, our results contribute to the understanding of primary and intrinsic empathy deficits of bvFTD and have important theoretical and clinical implications. PMID:25346685

  9. Oculomotor Anomalies in Attention-Deficit/Hyperactivity Disorder: Evidence for Deficits in Response Preparation and Inhibition

    Science.gov (United States)

    Mahone, E. Mark; Mostofsky, Stewart H.; Lasker, Adrian G.; Zee, David; Denckla, Martha B.

    2009-01-01

    Girls, but not boys, with attention deficit hyperactivity disorder (ADHD) have significantly longer visually guided saccades latencies. It is found that sex differences in children with ADHD extend beyond symptom presentation to the development of oculomotor control.

  10. Oculomotor Anomalies in Attention-Deficit/Hyperactivity Disorder: Evidence for Deficits in Response Preparation and Inhibition

    Science.gov (United States)

    Mahone, E. Mark; Mostofsky, Stewart H.; Lasker, Adrian G.; Zee, David; Denckla, Martha B.

    2009-01-01

    Girls, but not boys, with attention deficit hyperactivity disorder (ADHD) have significantly longer visually guided saccades latencies. It is found that sex differences in children with ADHD extend beyond symptom presentation to the development of oculomotor control.

  11. Enhanced learning deficits in female rats following lifetime pb exposure combined with prenatal stress.

    Science.gov (United States)

    Cory-Slechta, Deborah A; Stern, Sander; Weston, Doug; Allen, Joshua L; Liu, Sue

    2010-10-01

    Pb (lead) exposure and stress are co-occurring risk factors (particularly in low socioeconomic communities) that also act on common biological substrates and produce common adverse outcomes, including cognitive impairments. This study sought to determine whether lifetime Pb exposure combined with prenatal stress would enhance the cognitive deficits independently associated with each of these risk factors and to explore associated mechanisms of any observed impairments. Learning was evaluated using a multiple schedule of repeated learning and performance in female rats subjected to lifetime Pb exposure (0 or 50 ppm Pb in drinking water beginning in dams 2 months prior to breeding; blood Pb levels ∼10 μg/dl), to prenatal restraint stress on gestational days 16 and 17, or to both. Blood Pb, corticosterone levels, brain monoamines, and hippocampal nerve growth factor levels were also measured. Sequence-specific learning deficits produced by Pb, particularly the number of responses to correctly learn response sequences, were further enhanced by stress, whereas performance measures were unimpaired. Statistical analyses indicated significant relationships among corticosterone levels, frontal cortex dopamine (DA), nucleus accumbens dopamine turnover, and total responses required to learn sequences. This study demonstrates that Pb and stress can act together to produce selective and highly condition-dependent deficits in learning in female rats that may be related to glucocorticoid-mediated interactions with mesocorticolimbic regions of brain. These findings also underscore the critical need to evaluate toxicants in the context of other risk factors pertinent to human diseases and disorders.

  12. Attention-Deficit / Hyperactivity Disorder (ADHD): Data and Statistics

    Science.gov (United States)

    ... Search Form Controls Cancel Submit Search the CDC Attention-Deficit / Hyperactivity Disorder (ADHD) Note: Javascript is disabled ... claims to understand diagnosis and treatment patterns for Attention-Deficit/Hyperactivity Disorder (ADHD). On this page you ...

  13. Attention Deficit Hyperactivity Disorder and Tuberous Sclerosis Complex

    Science.gov (United States)

    ... Privacy Policy Sitemap Learn Engage Donate About TSC Attention Deficit Hyperactivity Disorder and TSC What is ADHD? Attention Deficit Hyperactivity Disorder (ADHD) is a common neurobehavioral disorder. It is ...

  14. Cognitive deficits in the remitted state of unipolar depressive disorder

    DEFF Research Database (Denmark)

    Hasselbalch, Jacob; Knorr, Ulla; Hasselbalch, Steen Gregers

    2012-01-01

    Patients with unipolar depressive disorder may present with cognitive deficits in the remitted state, and the aim of the present study was to investigate whether cognitive deficits within specific cognitive domains are present....

  15. The Ratio between Leave and Fruit Parameters on ‘William’ Pear Orchard Affected by Regulated Deficit Irrigation and Mulching

    Directory of Open Access Journals (Sweden)

    LAVDIM LEPAJA

    2016-03-01

    Full Text Available This field experiment was designed to assess the ratio between leave and fruit parameters on young ‘William’ pear trees after applied regulated deficit irrigation (RDI and mulching. Experiments related to deficit irrigation and particularly regulated deficit irrigation (RDI or partial rootzone drying depend heavily on weather conditions. Using a water budget methodology, four levels of irrigation, specifically 100% of evapotranspiration (ET as control and deficits of 80%, 60% and 40%, were applied to 10 trees during the season, 5 of which were mulched with wood chips at a 10 cm layer in first year of experiment while, 20 cm in second year. The experiment was conducted in Kosovo during 2013-2015 on a pear orchard of 10 ha using a nested experimental design. Using two-way ANOVA we found significant changes in a series of leave and fruit parameters. Our results confirmed that a moderate water stress increase yield while, reducing excessive vegetative growth. Regulated deficit irrigation (40 % has contributed to the reduction on leaf surface, leaf area, LAI. In addition, RDI affected to increase fruit numbers but decreasing fruit size. Compared with first year of experiment during 2015 in treatment 40 % were achieved 5 kg more than 2013 year. Except this, mulching had a positive effect on all parameter values measured compared to non-mulched trees. Our result indicated that regulated deficit irrigation can be successfully applied to pear also, RDI is an ideal water saving technique.

  16. Vowel Reduction in Japanese

    Institute of Scientific and Technical Information of China (English)

    Shirai; Setsuko

    2009-01-01

    This paper reports the result that vowel reduction occurs in Japanese and vowel reduction is the part of the language universality.Compared with English,the effect of the vowel reduction in Japanese is relatively weak might because of the absence of stress in Japanese.Since spectral vowel reduction occurs in Japanese,various types of researches would be possible.

  17. "Foreign and Public Deficits in Greece: In Search of Causality"

    OpenAIRE

    2013-01-01

    The paper discusses the trajectories of the Greek public deficit and sovereign debt over the last three decades and its connection to the political and economic environment of the same period. We pay special attention to the causality between the public and the foreign deficit. We argue that from 1980 to 1995 causality ran from the public deficit to the foreign deficit, but that due to the European monetary unification process and the adoption of the common currency, causality has reversed si...

  18. Wind turbine wakes; power deficit in clusters and wind farms

    DEFF Research Database (Denmark)

    Hansen, Kurt Schaldemose; Barthelmie, Rebecca

    2012-01-01

    The purpose of this presentation is to present recent power deficit analysis based on wind farm measurements. The power deficit is used to validate wind farm prediction models for different inflow conditions......The purpose of this presentation is to present recent power deficit analysis based on wind farm measurements. The power deficit is used to validate wind farm prediction models for different inflow conditions...

  19. Critical energy deficit and mortality in critically ill patients

    Directory of Open Access Journals (Sweden)

    Marcia Carolina Siqueira-Paese

    Full Text Available Objective: We investigate the influence of caloric and protein deficit on mortality and length of hospital stay of critically ill patients. Methods: A cohort prospective study including 100 consecutive patients in a tertiary intensive care unit (ICU receiving enteral or parenteral nutrition. The daily caloric and protein deficit were collected each day for a maximum of 30 days. Energy deficits were divided into critical caloric deficit (≥ 480 kcal/day and non-critical caloric deficit (≤ 480 kcal/day; and in critical protein deficit (≥ 20 g/day and non-critical protein deficit (≤ 20 g/day. The findings were correlated with hospital stay and mortality. Results: The mortality rate was 33%. Overall, the patients received 65.4% and 67.7% of the caloric and protein needs. Critical caloric deficit was found in 72% of cases and critical protein deficit in 70% of them. There was a significant correlation between length of stay and accumulated caloric deficit (R = 0.37; p < 0.001 and protein deficit (R = 0.28; p < 0.001. The survival analysis showed that mortality was greater in patients with both critical caloric (p < 0.001 and critical protein deficits (p < 0.01. The Cox regression analysis showed that critical protein deficit was associated with higher mortality (HR 0.25, 95% CI 0.07-0.93, p = 0.03. Conclusions: The incidence of caloric and protein deficit in the ICU is high. Both caloric and protein deficits increase the length of hospital stay, and protein deficit greater than 20 g/day is an independent factor for mortality in critical care unit.

  20. Medication for attention deficit-hyperactivity disorder and criminality.

    Science.gov (United States)

    Lichtenstein, Paul; Halldner, Linda; Zetterqvist, Johan; Sjölander, Arvid; Serlachius, Eva; Fazel, Seena; Långström, Niklas; Larsson, Henrik

    2012-11-22

    Attention deficit-hyperactivity disorder (ADHD) is a common disorder that has been associated with criminal behavior in some studies. Pharmacologic treatment is available for ADHD and may reduce the risk of criminality. Using Swedish national registers, we gathered information on 25,656 patients with a diagnosis of ADHD, their pharmacologic treatment, and subsequent criminal convictions in Sweden from 2006 through 2009. We used stratified Cox regression analyses to compare the rate of criminality while the patients were receiving ADHD medication, as compared with the rate for the same patients while not receiving medication. As compared with nonmedication periods, among patients receiving ADHD medication, there was a significant reduction of 32% in the criminality rate for men (adjusted hazard ratio, 0.68; 95% confidence interval [CI], 0.63 to 0.73) and 41% for women (hazard ratio, 0.59; 95% CI, 0.50 to 0.70). The rate reduction remained between 17% and 46% in sensitivity analyses among men, with factors that included different types of drugs (e.g., stimulant vs. nonstimulant) and outcomes (e.g., type of crime). Among patients with ADHD, rates of criminality were lower during periods when they were receiving ADHD medication. These findings raise the possibility that the use of medication reduces the risk of criminality among patients with ADHD. (Funded by the Swedish Research Council and others.).

  1. Infinitary Combinatory Reduction Systems: Normalising Reduction Strategies

    NARCIS (Netherlands)

    Ketema, Jeroen; Simonsen, Jakob Grue

    2010-01-01

    We study normalising reduction strategies for infinitary Combinatory Reduction Systems (iCRSs). We prove that all fair, outermost-fair, and needed-fair strategies are normalising for orthogonal, fully-extended iCRSs. These facts properly generalise a number of results on normalising strategies in fi

  2. Word Processing in Dyslexics: An Automatic Decoding Deficit?

    Science.gov (United States)

    Yap, Regina; Van Der Leu, Aryan

    1993-01-01

    Compares dyslexic children with normal readers on measures of phonological decoding and automatic word processing. Finds that dyslexics have a deficit in automatic phonological decoding skills. Discusses results within the framework of the phonological deficit and the automatization deficit hypotheses. (RS)

  3. Preterm Infant Hippocampal Volumes Correlate with Later Working Memory Deficits

    Science.gov (United States)

    Beauchamp, Miriam H.; Thompson, Deanne K.; Howard, Kelly; Doyle, Lex W.; Egan, Gary F.; Inder, Terrie E.; Anderson, Peter J.

    2008-01-01

    Children born preterm exhibit working memory deficits. These deficits may be associated with structural brain changes observed in the neonatal period. In this study, the relationship between neonatal regional brain volumes and working memory deficits at age 2 years were investigated, with a particular interest in the dorsolateral prefrontal…

  4. Preterm Infant Hippocampal Volumes Correlate with Later Working Memory Deficits

    Science.gov (United States)

    Beauchamp, Miriam H.; Thompson, Deanne K.; Howard, Kelly; Doyle, Lex W.; Egan, Gary F.; Inder, Terrie E.; Anderson, Peter J.

    2008-01-01

    Children born preterm exhibit working memory deficits. These deficits may be associated with structural brain changes observed in the neonatal period. In this study, the relationship between neonatal regional brain volumes and working memory deficits at age 2 years were investigated, with a particular interest in the dorsolateral prefrontal…

  5. Human brain lesion-deficit inference remapped.

    Science.gov (United States)

    Mah, Yee-Haur; Husain, Masud; Rees, Geraint; Nachev, Parashkev

    2014-09-01

    Our knowledge of the anatomical organization of the human brain in health and disease draws heavily on the study of patients with focal brain lesions. Historically the first method of mapping brain function, it is still potentially the most powerful, establishing the necessity of any putative neural substrate for a given function or deficit. Great inferential power, however, carries a crucial vulnerability: without stronger alternatives any consistent error cannot be easily detected. A hitherto unexamined source of such error is the structure of the high-dimensional distribution of patterns of focal damage, especially in ischaemic injury-the commonest aetiology in lesion-deficit studies-where the anatomy is naturally shaped by the architecture of the vascular tree. This distribution is so complex that analysis of lesion data sets of conventional size cannot illuminate its structure, leaving us in the dark about the presence or absence of such error. To examine this crucial question we assembled the largest known set of focal brain lesions (n = 581), derived from unselected patients with acute ischaemic injury (mean age = 62.3 years, standard deviation = 17.8, male:female ratio = 0.547), visualized with diffusion-weighted magnetic resonance imaging, and processed with validated automated lesion segmentation routines. High-dimensional analysis of this data revealed a hidden bias within the multivariate patterns of damage that will consistently distort lesion-deficit maps, displacing inferred critical regions from their true locations, in a manner opaque to replication. Quantifying the size of this mislocalization demonstrates that past lesion-deficit relationships estimated with conventional inferential methodology are likely to be significantly displaced, by a magnitude dependent on the unknown underlying lesion-deficit relationship itself. Past studies therefore cannot be retrospectively corrected, except by new knowledge that would render them redundant

  6. ACT Verbal Prep Course

    CERN Document Server

    Standridge, Nathan

    2012-01-01

    Comprehensive Prep for ACT Verbal. Every year, students pay 1,000 and more to test prep companies to prepare for the verbal sections of the ACT. Now you can get the same preparation in a book. The verbal sections are not easy. There is no quick fix that will allow you to "beat" the ACT, but it is very learnable. If you study hard and master the techniques in this book, your score will improve-significantly. The ACT cannot be "beaten." But it can be mastered-through hard work, analytical thought, and by training yourself to think like a test writer. Many of the exercises in this book are design

  7. Response inhibition in Attention deficit disorder and neurofibromatosis type 1 – clinically similar, neurophysiologically different

    Science.gov (United States)

    Bluschke, Annet; von der Hagen, Maja; Papenhagen, Katharina; Roessner, Veit; Beste, Christian

    2017-01-01

    There are large overlaps in cognitive deficits occurring in attention deficit disorder (ADD) and neurodevelopmental disorders like neurofibromatosis type 1 (NF1). This overlap is mostly based on clinical measures and not on in-depth analyses of neuronal mechanisms. However, the consideration of such neuronal underpinnings is crucial when aiming to integrate measures that can lead to a better understanding of the underlying mechanisms. Inhibitory control deficits, for example, are a hallmark in ADD, but it is unclear how far there are similar deficits in NF1. We thus compared adolescent ADD and NF1 patients to healthy controls in a Go/Nogo task using behavioural and neurophysiological measures. Clinical measures of ADD-symptoms were not different between ADD and NF1. Only patients with ADD showed increased Nogo errors and reductions in components reflecting response inhibition (i.e. Nogo-P3). Early perceptual processes (P1) were changed in ADD and NF1. Clinically, patients with ADD and NF1 thus show strong similarities. This is not the case in regard to underlying cognitive control processes. This shows that in-depth analyses of neurophysiological processes are needed to determine whether the overlap between ADD and NF1 is as strong as assumed and to develop appropriate treatment strategies. PMID:28262833

  8. Terminological and Definitional Problems of Deficit and Debt in the Polish and EU Law of Public Finance

    Directory of Open Access Journals (Sweden)

    Ewa Lotko

    2016-06-01

    Full Text Available In the Polish and the EU public finances law there are serious terminological difficulties concerning the deficit and the debt. They arise first from the terminological chaos in this field and second from the parallel application of the EU and the Polish methodology of calculating of deficit and debt. Thus, the paper aims to explain the terminological and definitional problems of deficit and debt in the public finances law using unobtrusive research consisting of the detailed analysis of the Polish and EU legislation. Although there is no doubt that it would be desirable to order the applied terms, in the current legal situation, it would be extremely difficult, as it would require the changes to the Constitution, laws, and modification of translations of UE acts. The solution to the problem, presenting additional advantages, could consist of full transition to the EU methodology by the renouncement from the Polish methodology.

  9. Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia.

    Science.gov (United States)

    Arnsten, Amy F T; Girgis, Ragy R; Gray, David L; Mailman, Richard B

    2017-01-01

    Schizophrenia is characterized by profound cognitive deficits that are not alleviated by currently available medications. Many of these cognitive deficits involve dysfunction of the newly evolved, dorsolateral prefrontal cortex (dlPFC). The brains of patients with schizophrenia show evidence of dlPFC pyramidal cell dendritic atrophy, likely reductions in cortical dopamine, and possible changes in dopamine D1 receptors (D1R). It has been appreciated for decades that optimal levels of dopamine are essential for dlPFC working memory function, with many beneficial actions arising from D1R stimulation. D1R are concentrated on dendritic spines in the primate dlPFC, where their stimulation produces an inverted-U dose response on dlPFC neuronal firing and cognitive performance during working memory tasks. Research in both academia and the pharmaceutical industry has led to the development of selective D1 agonists, e.g., the first full D1 agonist, dihydrexidine, which at low doses improved working memory in monkeys. Dihydrexidine has begun to be tested in patients with schizophrenia or schizotypal disorder. Initial results are encouraging, but studies are limited by the pharmacokinetics of the drug. These data, however, have spurred efforts toward the discovery and development of improved or novel new compounds, including D1 agonists with better pharmacokinetics, functionally selective D1 ligands, and D1R positive allosteric modulators. One or several of these approaches should allow optimization of the beneficial effects of D1R stimulation in the dlPFC that can be translated into clinical practice. Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  10. Working and strategic memory deficits in schizophrenia

    Science.gov (United States)

    Stone, M.; Gabrieli, J. D.; Stebbins, G. T.; Sullivan, E. V.

    1998-01-01

    Working memory and its contribution to performance on strategic memory tests in schizophrenia were studied. Patients (n = 18) and control participants (n = 15), all men, received tests of immediate memory (forward digit span), working memory (listening, computation, and backward digit span), and long-term strategic (free recall, temporal order, and self-ordered pointing) and nonstrategic (recognition) memory. Schizophrenia patients performed worse on all tests. Education, verbal intelligence, and immediate memory capacity did not account for deficits in working memory in schizophrenia patients. Reduced working memory capacity accounted for group differences in strategic memory but not in recognition memory. Working memory impairment may be central to the profile of impaired cognitive performance in schizophrenia and is consistent with hypothesized frontal lobe dysfunction associated with this disease. Additional medial-temporal dysfunction may account for the recognition memory deficit.

  11. Soccer heading frequency predicts neuropsychological deficits.

    Science.gov (United States)

    Witol, Adrienne D; Webbe, Frank M

    2003-05-01

    This study investigated the presence of neuropsychological deficits associated with hitting the ball with one's head (heading) during soccer play. A neuro-cognitive test battery was administered to 60 male soccer players, high school, amateur and professional level, and 12 nonplaying control participants. The effects of currently reported heading behavior as well as that of estimated lifetime heading experience on neuropsychological test performance were examined. Players with the highest lifetime estimates of heading had poorer scores on scales measuring attention, concentration, cognitive flexibility and general intellectual functioning. Players' current level of heading was less predictive of neuro-cognitive level. Comparison of individual scores to age-appropriate norms revealed higher probabilities of clinical levels of impairment in players who reported greater lifetime frequencies of heading. Because of the worldwide popularity of the game, continued research is needed to assess the interaction between heading and soccer experience in the development of neuropsychological deficits associated with soccer play.

  12. Jealousy delirium associated with memory deficits

    Directory of Open Access Journals (Sweden)

    Orazio Zanetti

    2007-09-01

    Full Text Available Alzheimer’s disease is a progressive and fatal neurodegenerative disorder manifested by cognitive and memory deterioration, progressive impairment of activities of daily living, and a variety of neuropsychiatric symptoms and behavioural disturbances. A correct and early diagnosis not only allows prompt treatment but can also give the person with Alzheimer’s and his family more time to arm themselves with knowledge about this type of dementia and the best way to live with the disease. The role of Family Physician is very important in early diagnosis: dementia may be suspected if memory deficits are exhibited during the medical history and physical examination. Information from the patient’s family members, friends and caregivers may also point to signs of dementia. We report a case of a 75-years-old man who was suffering from cognitive deficits and behavioural problems: the first disease symptom was a strong feeling of jealousy towards his wife.

  13. Traumatic knee extension deficit (the locked knee)

    DEFF Research Database (Denmark)

    Helmark, I C; Neergaard, K; Krogsgaard, M R

    2007-01-01

    In the present study we investigated the validity of magnetic resonance imaging (MRI) and arthroscopy in knees with acute, traumatic extension deficit (the "locked knee"), and evaluated whether arthroscopy of knees with no mechanical pathology could be avoided by MRI evaluation. The study consisted...... of 50 patients who had an acute, traumatic extension deficit of the knee. All patients were submitted to MRI prior to arthroscopy. Following MRI and surgery, standardized forms were filled out, attempting to objectify the findings. The orthopaedic surgeon was not aware of the MRI result prior to surgery......, the following results were calculated for the overall appearance of a lesion able to cause locking: Positive predictive value = 0.85, negative predictive value = 0.77, sensitivity = 0.95, specificity = 0.53. Two knees were erroneously evaluated with no mechanical locking at MRI (one bucket-handle lesion and one...

  14. The Apocryphal Acts Of Andrew

    NARCIS (Netherlands)

    Bremmer, Jan N.

    2000-01-01

    Following the first three volumes of the new series on the Acts of John (1995), the Acts of Paul and Thecla (1996) and the Acts of Peter (1998), this new volume is devoted to the Acts of Andrew. After a study of the relationship between the Acts of Andrew and the Acts of Andrew and Matthias, the maj

  15. Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.

    LENUS (Irish Health Repository)

    Behan, Aine T

    2011-01-01

    Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.

  16. Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.

    LENUS (Irish Health Repository)

    Behan, Aine T

    2012-02-01

    Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.

  17. Common Cognitive Deficits in Children with Attention-Deficit/Hyperactivity Disorder and Autism: Working Memory and Visual-Motor Integration

    Science.gov (United States)

    Englund, Julia A.; Decker, Scott L.; Allen, Ryan A.; Roberts, Alycia M.

    2014-01-01

    Cognitive deficits in working memory (WM) are characteristic features of Attention-Deficit/Hyperactivity Disorder (ADHD) and autism. However, few studies have investigated cognitive deficits using a wide range of cognitive measures. We compared children with ADHD ("n" = 49) and autism ("n" = 33) with a demographically matched…

  18. Local reduction in physics

    Science.gov (United States)

    Rosaler, Joshua

    2015-05-01

    A conventional wisdom about the progress of physics holds that successive theories wholly encompass the domains of their predecessors through a process that is often called "reduction." While certain influential accounts of inter-theory reduction in physics take reduction to require a single "global" derivation of one theory's laws from those of another, I show that global reductions are not available in all cases where the conventional wisdom requires reduction to hold. However, I argue that a weaker "local" form of reduction, which defines reduction between theories in terms of a more fundamental notion of reduction between models of a single fixed system, is available in such cases and moreover suffices to uphold the conventional wisdom. To illustrate the sort of fixed-system, inter-model reduction that grounds inter-theoretic reduction on this picture, I specialize to a particular class of cases in which both models are dynamical systems. I show that reduction in these cases is underwritten by a mathematical relationship that follows a certain liberalized construal of Nagel/Schaffner reduction, and support this claim with several examples. Moreover, I show that this broadly Nagelian analysis of inter-model reduction encompasses several cases that are sometimes cited as instances of the "physicist's" limit-based notion of reduction.

  19. Stigma in attention deficit hyperactivity disorder

    OpenAIRE

    Anna K Mueller; Fuermaier, Anselm B. M.; Koerts, Janneke; Tucha, Lara

    2012-01-01

    Attention deficit hyperactivity disorder (ADHD) is a frequently diagnosed disorder in child- and adulthood with a high impact affecting multiple facets of social life. Therefore, patients suffering from ADHD are at high risk to be confronted with stigma, prejudices, and discrimination. A review of the empirical research in the field of ADHD with regard to stigma was performed. The findings of investigations in this field were clustered in different categories, including stigma in children wit...

  20. Attention deficit hyperactivity disorder in prison inmates

    OpenAIRE

    Ginsberg, Ylva

    2012-01-01

    Background: Attention deficit hyperactivity disorder (ADHD) is an inherited developmental disorder with early onset, chronically persisting in the vast majority of cases. ADHD is associated with pervasive cognitive, emotional and functional impairments, as well as an increased rate of coexisting disorders. ADHD in the presence of early disruptive behaviours increase the risk for later delinquency. ADHD is estimated to be present in about 25-45% of adult prison inmates, thus 10-times increased...

  1. Sporadic hemiplegic migraine with permanent neurological deficits.

    Science.gov (United States)

    Schwedt, Todd J; Zhou, Jiying; Dodick, David W

    2014-01-01

    By definition, the neurologic impairments of hemiplegic migraine are reversible. However, a few cases of permanent neurologic deficits associated with hemiplegic migraine have been reported. Herein, we present the case of a patient with permanent impairments because of hemiplegic migraine despite normalization of associated brain magnetic resonance imaging abnormalities. Cases like these suggest the need to consider aggressive prophylactic therapy for patients with recurrent hemiplegic migraine attacks.

  2. [Treatment of attention deficit/hyperactivity disorder].

    Science.gov (United States)

    Purper-Ouakil, Diane

    2006-02-28

    Attention deficit/hyperactivity disorder (ADHD) is a chronic and invalidating condition, whose negative consequences on psychosocial functioning calls for efficacious treatment plans. Several treatments have been proven to be effective: some parent and children treatment programs, psychostimulants, atomoxetine. Most of these therapeutic options are not easily available to patients and families (psychoeducational programs are rarely used in France). Primary care professionals can help families to access valid information, discuss treatment plans and monitor treatment.

  3. Pollination deficits in UK apple orchards

    OpenAIRE

    Garratt, M.P.D.; Truslove, C.L.; Coston, D. J.; Evans, R. L.; Moss, E. D.; Dodson, C.; Jenner, N.; Biesmeijer, J.C.; Potts, S. G.

    2013-01-01

    Apple production in the UK is worth over £100 million per annum and this production is heavily dependent on insect pollination. Despite its importance, it is not clear which insect pollinators carry out the majority of this pollination. Furthermore, it is unknown whether current UK apple production, in terms of both yield and quality, suffers pollination deficits and whether production value could be increased through effective management of pollination services. The present study set out to ...

  4. Sensorimotor gating deficits in multiple system atrophy

    DEFF Research Database (Denmark)

    Zoetmulder, Marielle; Biernat, Heidi Bryde; Nikolic, Miki

    2014-01-01

    Prepulse inhibition (PPI) of the auditory blink reflex is a measure of sensorimotor gating, which reflects an organism's ability to filter out irrelevant sensory information. PPI has never been studied in patients with multiple system atrophy (MSA), although sensorimotor deficits are frequently...... associated with synucleinopathies. We investigated whether alterations in PPI were more pronounced in MSA compared with Parkinson's disease (PD), idiopathic rapid eye movement sleep behavior disorder (iRBD) and healthy controls....

  5. Marine Mammal Protection Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Marine Mammal Protection Act (MMPA or Act) prohibits, with certain exceptions, the "take" of marine mammals in U.S. waters and by U.S. citizens on the high seas,...

  6. Vision Deficits in Adults with Down Syndrome

    Science.gov (United States)

    Krinsky-McHale, Sharon J.; Silverman, Wayne; Gordon, James; Devenny, Darlynne A.; Oley, Nancy; Abramov, Israel

    2013-01-01

    Background In individuals with Down syndrome virtually all structures of the eye have some abnormality which likely diminishes vision. We examined basic vision functions in adults with Down syndrome. Materials and Methods Participants completed a battery of psychophysical tests which probed a comprehensive array of visual functions. The performance of adults with Down syndrome was compared to younger and older adults without intellectual disability. Results Adults with Down syndrome had significant vision deficits; reduced sensitivity across spatial frequencies and temporal modulation rates, reduced stereopsis, impaired vernier acuity, and anomalies in colour discrimination. The pattern of deficits observed was similar to those seen by researchers examining adults with Alzheimer’s disease. Conclusions Our findings suggest that a common mechanism may be responsible for the pattern of deficits observed, possibly the presence of Alzheimer’s disease neuropathology in the visual association cortex. We also showed that individuals with mild to moderate intellectual disability are capable of participating in studies employing state-of-the-art psychophysical procedures. This has wider implications in terms of their ability to participate in research that use similar techniques. PMID:23784802

  7. Narrative discourse deficits in amyotrophic lateral sclerosis

    Science.gov (United States)

    Menaged, Anna; Olm, Christopher; McMillan, Corey T.; Boller, Ashley; Irwin, David J.; McCluskey, Leo; Elman, Lauren; Grossman, Murray

    2014-01-01

    Objective: We examined narrative discourse in amyotrophic lateral sclerosis (ALS) to assess the role of executive functioning in support of language and the neuroanatomical basis for such support. Methods: We analyzed a semistructured speech sample in 26 patients with ALS and 19 healthy seniors for narrative discourse features of coherence. Regression analyses related a measure of discourse coherence (“local connectedness”) to gray matter atrophy and reduced white matter fractional anisotropy. Results: Patients with ALS were impaired relative to controls on measures of discourse adequacy, including local connectedness and maintenance of the theme. These discourse measures were related to measures of executive functioning but not to motor functioning. Regressions related local connectedness to gray matter atrophy in ventral and dorsal prefrontal regions and to reduced fractional anisotropy in white matter tracts mediating projections between prefrontal regions. Conclusion: Patients with ALS exhibit deficits in their ability to organize narrative discourse. These deficits appear to be related in part to executive limitations. Consistent with the hypothesis that ALS is a multisystem disorder, this deficit is related to disease in prefrontal regions. PMID:24991038

  8. Medical Comorbidities in Attention Deficit Hyperactivity Disorder

    Directory of Open Access Journals (Sweden)

    Irem Yalug

    2009-09-01

    Full Text Available Attention Deficit Hyperactivity Disorder is one of the most common developmental disorders of childhood with a reported world-wide prevalence of 8 to 12 %. In studies conducted in our country the prevalence rates in community were reported to vary between 8.6 to 8.1 % while clinical prevalence rates were reported to vary between 8.6 to 29.44 %. Fifty to eighty percent of cases were reported to continue into adolescence while thirty to fifty percent may continue into adulthood. Attention deficit hyperactivity disorder is known to accompany subtle physical anomalies, allergic and neurologic disorders, obesity and eating disorders, traumatic injuries, risky sexual behavior, sleep disorders, substance and alcohol use, axis I and II disorders, occupational, legal and academic problems and increased treatment expenditures. Though the effects of this disorder continue throughout life, create burdens to the society along with its treatment as well as disabling the affected patients through their lives, and receive increasing attention in recent years, reviews focusing on problems associated with it are lacking. Therefore, this study aimed to summarize the results of previous studies conducted about medical comorbidities in attention deficit hyperactivity disorder.

  9. Word Learning Deficits in Children With Dyslexia.

    Science.gov (United States)

    Alt, Mary; Hogan, Tiffany; Green, Samuel; Gray, Shelley; Cabbage, Kathryn; Cowan, Nelson

    2017-04-14

    The purpose of this study is to investigate word learning in children with dyslexia to ascertain their strengths and weaknesses during the configuration stage of word learning. Children with typical development (N = 116) and dyslexia (N = 68) participated in computer-based word learning games that assessed word learning in 4 sets of games that manipulated phonological or visuospatial demands. All children were monolingual English-speaking 2nd graders without oral language impairment. The word learning games measured children's ability to link novel names with novel objects, to make decisions about the accuracy of those names and objects, to recognize the semantic features of the objects, and to produce the names of the novel words. Accuracy data were analyzed using analyses of covariance with nonverbal intelligence scores as a covariate. Word learning deficits were evident for children with dyslexia across every type of manipulation and on 3 of 5 tasks, but not for every combination of task/manipulation. Deficits were more common when task demands taxed phonology. Visuospatial manipulations led to both disadvantages and advantages for children with dyslexia. Children with dyslexia evidence spoken word learning deficits, but their performance is highly dependent on manipulations and task demand, suggesting a processing trade-off between visuospatial and phonological demands.

  10. Pollination deficits in UK apple orchards

    Directory of Open Access Journals (Sweden)

    Michael Paul Douglas Garratt

    2014-02-01

    Full Text Available Apple production in the UK is worth over £100 million per annum and this production is heavily dependent on insect pollination. Despite its importance, it is not clear which insect pollinators carry out the majority of this pollination. Furthermore, it is unknown whether current UK apple production, in terms of both yield and quality, suffers pollination deficits and whether production value could be increased through effective management of pollination services. The present study set out to address some of these unknowns and showed that solitary bee activity is high in orchards and that they could be making a valuable contribution to pollination. Furthermore, fruit set and apple seed number were found to be suffering potential pollination deficits although these were not reflected in apple quality. Deficits could be addressed through orchard management practices to improve the abundance and diversity of wild pollinators. Such practices include provision of additional floral resources and nesting habitats as well as preservation of semi-natural areas. The cost effectiveness of such strategies would need to be understood taking into account the potential gains to the apple industry.

  11. Pollination deficits in UK apple orchards

    Directory of Open Access Journals (Sweden)

    Simon Potts

    2013-10-01

    Full Text Available Apple production in the UK is worth over £100 million per annum and this production is heavily dependent on insect pollination. Despite its importance, it is not clear which insect pollinators carry out the majority of this pollination. Furthermore, it is unknown whether current UK apple production, in terms of both yield and quality, suffers pollination deficits and whether production value could be increased through effective management of pollination services. The present study set out to address some of these unknowns and showed that solitary bee activity is high in orchards and that they could be making a valuable contribution to pollination. Furthermore, fruit set and apple seed number were found to be suffering potential pollination deficits although these were not reflected in apple quality. Deficits could be addressed through orchard management practices to improve the abundance and diversity of wild pollinators. Such practices include provision of additional floral resources and nesting habitats as well as preservation of semi-natural areas. The cost effectiveness of such strategies would need to be understood taking into account the potential gains to the apple industry.

  12. Acetylcholinesterase inhibition ameliorates deficits in motivational drive

    Directory of Open Access Journals (Sweden)

    Martinowich Keri

    2012-03-01

    Full Text Available Abstract Background Apathy is frequently observed in numerous neurological disorders, including Alzheimer's and Parkinson's, as well as neuropsychiatric disorders including schizophrenia. Apathy is defined as a lack of motivation characterized by diminished goal-oriented behavior and self-initiated activity. This study evaluated a chronic restraint stress (CRS protocol in modeling apathetic behavior, and determined whether administration of an anticholinesterase had utility in attenuating CRS-induced phenotypes. Methods We assessed behavior as well as regional neuronal activity patterns using FosB immunohistochemistry after exposure to CRS for 6 h/d for a minimum of 21 d. Based on our FosB findings and recent clinical trials, we administered an anticholinesterase to evaluate attenuation of CRS-induced phenotypes. Results CRS resulted in behaviors that reflect motivational loss and diminished emotional responsiveness. CRS-exposed mice showed differences in FosB accumulation, including changes in the cholinergic basal forebrain system. Facilitating cholinergic signaling ameliorated CRS-induced deficits in initiation and motivational drive and rescued immediate early gene activation in the medial septum and nucleus accumbens. Conclusions Some CRS protocols may be useful for studying deficits in motivation and apathetic behavior. Amelioration of CRS-induced behaviors with an anticholinesterase supports a role for the cholinergic system in remediation of deficits in motivational drive.

  13. Cognitive deficits in patients with brain tumor

    Institute of Scientific and Technical Information of China (English)

    SHEN Chao; BAO Wei-min; YANG Bo-jie; XIE Rong; CAO Xiao-yun; LUAN Shi-hai; MAO Ying

    2012-01-01

    Objective To discuss the present status and progress of clinical research on the cognitive effects caused by different types of brain tumors and common treatments.Data sources The data used in this review were mainly from PubMed articles published in English from 1990 to Febuary 2012.Research terms were "cognitive deficits" or "cognitive dysfunction".Study selection Articals including any information about brain tumor related cognitive deficits were selected.Results It is widely accepted that brain tumors and related treatments can impair cognitive function across manydomains,and can impact on patients' quality of life.Tumor localization,lateralization,surgery,drugs,radiotherapy and chemotherapy are all thought to be important factors in this process.However,some conflicting findings regarding brain tumor-related cognitive deficits have been reported.It can be difficult to determine the mechanism of these treatments,such as chemotherapy,antibiotics,antiepileptics,and steroids.Future research is needed to clarify these potential treatment effects.Conclusions Cognitive function is important for patients with brain tumor.Much more focus has been paid on this field.It should be regarded as an important prognostic index for the patients with brain tumor,and neuropsychological tests should be used in regular examinations.

  14. Reduction in language testing

    DEFF Research Database (Denmark)

    Dimova, Slobodanka; Jensen, Christian

    2013-01-01

    /video recorded speech samples and written reports produced by two experienced raters after testing. Our findings suggest that reduction or reduction-like pronunciation features are found in tested L2 speech, but whenever raters identify and comment on such reductions, they tend to assess reductions negatively......This study represents an initial exploration of raters' comments and actual realisations of form reductions in L2 test speech performances. Performances of three L2 speakers were selected as case studies and illustrations of how reductions are evaluated by the raters. The analysis is based on audio...

  15. Separate and combined responses to water deficit and UV-B radiation.

    Science.gov (United States)

    Bandurska, Hanna; Niedziela, Justyna; Chadzinikolau, Tamara

    2013-12-01

    Crops and other plants in natural conditions are routinely affected by several stresses acting simultaneously or in sequence. In areas affected by drought, plants may also be exposed to enhanced UV-B radiation (280-315nm). Each of these stress factors differently affects cellular metabolism. A common consequence of plant exposure to the separate action of water deficit and UV-B radiation is the enhanced generation of reactive oxygen species (ROS) causing damage to proteins, lipids, carbohydrates and DNA. Despite this destructive activity, ROS also act as signalling molecules in cellular processes responsible for defence responses. Plants have evolved many physiological and biochemical mechanisms that avoid or tolerate the effects of stress factors. Water deficit avoidance leads to stomatal closure, stimulation of root growth, and accumulation of free proline and other osmolytes. Secondary metabolites (flavonols, flavones and anthocyanins) that accumulate in epidermal cells effectively screen UV-B irradiation and reduce its penetration to mesophyll tissue. The coordinated increased activity of the enzymatic antioxidant defence system such as up-regulation of superoxide dismutase, catalase, guaiacol peroxidase, ascorbate peroxidase and glutathione reductase is an important mechanism of tolerance to water deficit and UV-B radiation. The accumulation of low molecular antioxidants (proline, glycine betaine, ascorbate and glutathione) can also contribute to tolerance to water deficit. Polyamines, tocopherol, carotenoids, alkaloids, flavonoids and other secondary metabolites participate in the removal of ROS under conditions of increased UV-B radiation. The combination of water deficit and UV-B radiation induces responses that can be antagonistic, additive or synergistic in comparison with the action of single stresses. UV-B radiation may enhance resistance to water deficit and vice versa. Hydrogen peroxide, nitric oxide (NO), abscisic acid (ABA), jasmonic acid, ethylene

  16. Metacognition deficits as a risk factor for prospective motivation deficits in schizophrenia spectrum disorders.

    Science.gov (United States)

    Luther, Lauren; Firmin, Ruth L; Minor, Kyle S; Vohs, Jenifer L; Buck, Benjamin; Buck, Kelly D; Lysaker, Paul H

    2016-11-30

    Although motivation deficits are key determinants of functional outcomes, little is known about factors that contribute to prospective motivation in people with schizophrenia. One candidate factor is metacognition, or the ability to form complex representations about oneself, others, and the world. This study aimed to assess whether metacognition deficits were a significant predictor of reduced prospective motivation, after controlling for the effects of baseline motivation, anticipatory pleasure, and antipsychotic medication dose. Fifty-one participants with a schizophrenia spectrum disorder completed measures of metacognition and anticipatory pleasure at baseline; participants also completed a measure of motivation at baseline and six months after the initial assessment. Baseline antipsychotic dose was obtained from medical charts. Hierarchical regression analysis revealed that lower levels of baseline metacognition significantly predicted reduced levels of motivation assessed six months later, after controlling for baseline levels of motivation, anticipatory pleasure, and antipsychotic dose. Higher baseline antipsychotic dose was also a significant predictor of reduced six month motivation. Results suggest that metacognition deficits and higher antipsychotic dose may be risk factors for the development of motivation deficits in schizophrenia. Implications include utilizing interventions to improve metacognition in conjunction with evaluating and possibly lowering antipsychotic dose for people struggling with motivation deficits. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  17. Modern Reduction Methods

    CERN Document Server

    Andersson, Pher G

    2008-01-01

    With its comprehensive overview of modern reduction methods, this book features high quality contributions allowing readers to find reliable solutions quickly and easily. The monograph treats the reduction of carbonyles, alkenes, imines and alkynes, as well as reductive aminations and cross and heck couplings, before finishing off with sections on kinetic resolutions and hydrogenolysis. An indispensable lab companion for every chemist.

  18. Motor Timing Deficits in Children with Attention-Deficit/Hyperactivity Disorder

    Science.gov (United States)

    Zelaznik, Howard N.; Vaughn, Aaron J.; Green, John T.; Smith, Alan L.; Hoza, Betsy; Linnea, Kate

    2011-01-01

    Children with Attention-Deficit/Hyperactivity Disorder (ADHD) are thought to have fundamental deficits in the allocation of attention for information processing. Furthermore, it is believed that these children possess a fundamental difficulty in motoric timing, an assertion that has been explored recently in adults and children. In the present study we extend this recent work by fully exploring the classic Wing and Kristofferson (1973) analysis of timing with typically developing children (n = 24) and children with ADHD (n = 27). We provide clear evidence that not only do children with ADHD have an overall timing deficit, they also time less consistently when using a similar strategy to typically developing children. The use of the Wing and Kristofferson approach to timing, we argue, will result in the discovery of robust ADHD-related timing differences across a variety of situations. PMID:21852012

  19. 75 FR 63703 - Privacy Act of 1974; Privacy Act Regulation

    Science.gov (United States)

    2010-10-18

    ... CFR Part 261a Privacy Act of 1974; Privacy Act Regulation AGENCY: Board of Governors of the Federal...) is issuing a final rule to amend its regulation implementing the Privacy Act of 1974 (Privacy Act..., and applicants for Board employment, for access to their records under the Privacy Act; the amendment...

  20. Executive and attentional contributions to Theory of Mind deficit in attention deficit/hyperactivity disorder (ADHD).

    Science.gov (United States)

    Mary, Alison; Slama, Hichem; Mousty, Philippe; Massat, Isabelle; Capiau, Tatiana; Drabs, Virginie; Peigneux, Philippe

    2016-01-01

    Attention deficit/hyperactivity disorder (ADHD) in children has been associated with attentional and executive problems, but also with socioemotional difficulties possibly associated with deficits in Theory of Mind (ToM). Socioemotional problems in ADHD are associated with more negative prognoses, notably interpersonal, educational problems, and an increased risk of developing other psychiatric disorders that emphasize the need to clarify the nature of their ToM deficits. In this study, we hypothesized that ToM dysfunction in children with ADHD is largely attributable to their attentional and/or executive deficits. Thirty-one children with ADHD (8-12 years, IQ > 85) and 31 typically developing (TD) children were assessed using executive functions (inhibition, planning, and flexibility) and attentional tasks, as well as two advanced ToM tasks (Reading the Mind in the Eyes and Faux Pas) involving different levels of executive control. Children with ADHD performed more poorly than TD children in attentional, executive function, and ToM tasks. Linear regression analyses conducted in the ADHD group indicated that inhibition scores predicted performance on the "Faux Pas" task the best, while attention scores were the best for predicting performance on the Reading the Mind in the Eyes task. When controlled for inhibition and attentional variables, ToM performance in children with ADHD was actually similar to TD children. Contrarily, controlling for ToM scores did not normalize performance for inhibition and attentional tasks in children with ADHD. This unidirectional relationship suggests that deficits in the EF and attentional domains are responsible for ToM deficits in ADHD, which therefore may contribute to their socioemotional difficulties.