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Sample records for defense programs dp

  1. Review of Sandia National Laboratories - Albuquerque, New Mexico DOE/DP critical skills development programs FY03.

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Katherine Sue; Wilson, Dominique Foley; Chalamidas, Anna K.

    2004-04-01

    Sandia National Laboratories has developed a portfolio of programs to address the critical skills needs of the DP labs, as identified by the 1999 Chiles Commission Report. The goals are to attract and retain the best and the brightest students and transition them into Sandia - and DP Complex - employees. The US Department of Energy/Defense Programs University Partnerships funded nine laboratory critical skills development programs in FY03. This report provides a qualitative and quantitative evaluation of these programs and their status.

  2. Review of the Sandia National Laboratories -- Albuquerque, New Mexico DOE/DP Critical Skills Development Programs FY '02

    Energy Technology Data Exchange (ETDEWEB)

    CLARK, KATHERINE SUE

    2003-02-01

    Sandia National Laboratories has developed a portfolio of programs to address the critical skills needs of the DP labs, as identified by the 1999 Chiles Commission Report. The goals are to attract and retain the best and the brightest students and transition them into Sandia--and DP Complex--employees. The US Department of Energy/Defense Programs University Partnerships funded seven laboratory critical skills development programs in FY02. This report provides a qualitative and quantitative evaluation of these programs and their status.

  3. Nicotine impact on melanogenesis and antioxidant defense system in HEMn-DP melanocytes.

    Science.gov (United States)

    Delijewski, Marcin; Wrześniok, Dorota; Otręba, Michał; Beberok, Artur; Rok, Jakub; Buszman, Ewa

    2014-10-01

    Nicotine is a compound of tobacco plants and is responsible for addictive properties of tobacco which is used by about one billion of smokers all over the world. Recently, nicotine has drawn even more attention due to its presumed neuroprotective and antioxidant features as far as common use in various forms of smoking cessation therapies. It is suggested that nicotine may be accumulated in human tissues containing melanin. This may in turn influence biochemical processes in human cells producing melanin. The aim of this study was to examine the impact of nicotine on melanogenesis and antioxidant defense system in cultured normal human melanocytes (HEMn-DP). Nicotine induced concentration-dependent loss in melanocytes viability. The value of EC50 was determined to be 2.52 mM. Nicotine modulated melanin biosynthesis in normal human melanocytes. Significant changes in hydrogen peroxide content and cellular antioxidant enzymes: SOD, CAT, and GPx activities were stated in melanocytes exposed to nicotine, which indicates alterations of antioxidant defense system. The results obtained in vitro may explain a potential influence of nicotine on biochemical processes in melanocytes in vivo during long-term exposition to nicotine.

  4. DEFENSE PROGRAMS RISK MANAGEMENT FRAMEWORK

    Directory of Open Access Journals (Sweden)

    Constantin PREDA

    2012-01-01

    Full Text Available For the past years defense programs have faced delays in delivering defense capabilities and budget overruns. Stakeholders are looking for ways to improve program management and the decision making process given the very fluid and uncertain economic and political environment. Consequently, they have increasingly resorted to risk management as the main management tool for achieving defense programs objectives and for delivering the defense capabilities strongly needed for the soldiers on the ground on time and within limited defense budgets. Following a risk management based decision-making approach the stakeholders are expected not only to protect program objectives against a wide range of risks but, at the same time, to take advantage of the opportunities to increase the likelihood of program success. The prerequisite for making risk management the main tool for achieving defense programs objectives is the design and implementation of a strong risk management framework as a foundation providing an efficient and effective application of the best risk management practices. The aim of this paper is to examine the risk management framework for defense programs based on the ISO 31000:2009 standard, best risk management practices and the defense programs’ needs and particularities. For the purposes of this article, the term of defense programs refers to joint defense programs.

  5. Defense Meteorological Satellite Program (DMSP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Defense Meteorological Satellite Program (DMSP) satellites collect visible and infrared cloud imagery as well as monitoring the atmospheric, oceanographic,...

  6. AFRL Defensive IO Programs

    Science.gov (United States)

    2007-11-02

    Wireless Information Assurance • Steganography • Air Force Enterprise Defense (AFED) 10 Distributed Agents for Information Warfare Operational...information (images, documents, overlays, audio , links, etc.) •multi-level data release to coalition forces; key-based access •covert communication...maximize throughput of communication channels Data Hiding/Embedding Steganography Watermarking Steganalysis 14 Payoffs • Integrates existing

  7. Defense programs occurrence analysis report for third quarter CY-1991

    Energy Technology Data Exchange (ETDEWEB)

    1991-12-01

    The quarterly Defense Programs Occurrence Analysis Report (DPOAR) is compiled by the Office of Self-Assessment and Emergency Management (DP-9). It utilizes the Occurrence Reporting and Processing System (ORPS) data to assess the quality and effectiveness of the reporting process and the significance of the occurrences. In addition, areas where further improvement and corrective actions are necessary is fully demonstrated by an analysis of the data. The results of the assessment may also be used as the basis for conducting other evaluations such as the diagnostic and augmented evaluations. This quarterly report provides feedback to DOE/DP and contractor management to improve the control of operations and achieve a higher standard of excellence. The report analyzes one year of ORPS data at the end of each calendar quarter, therefore, the performance of DP Field Offices and facilities will be continuously compared to their past quarter and yearly performances. During this assessment from 1 October 1990 through 30 September 1991, there were a number of initiatives that were undertaken by Field Office management to improve the overall performance and the quality of the Occurrence Reporting and Processing System. These initiatives include the training of their staff for self-assessment activities. These intiatives can be found in the programs implemented according to the DOE Conduct of Operations and Occurrence Reporting and Processing of Operations Information Orders. These initiatives were found to be, based on the ORPS data, stronger at Albuquerque, Nevada, Oak Ridge Field Offices and Richland DP facilities.

  8. Energetic materials research and development activities at Sandia National Laboratories supported under DP-10 programs

    Energy Technology Data Exchange (ETDEWEB)

    Ratzel, A.C. III

    1998-09-01

    This report provides summary descriptions of Energetic Materials (EM) Research and Development activities performed at Sandia National Laboratories and funded through the Department of Energy DP-10 Program Office in FY97 and FY98. The work falls under three major focus areas: EM Chemistry, EM Characterization, and EM Phenomenological Model Development. The research supports the Sandia component mission and also Sandia's overall role as safety steward for the DOE Nuclear Weapons Complex.

  9. Risk Management Programs for Defense Acquisition Systems

    Science.gov (United States)

    2007-11-02

    The audit objective was to evaluate the effectiveness of risk management programs for Defense acquisition systems. Specifically, we determined whether DoD risk management policies and procedures for Defense acquisition systems were effectively implemented and what impact risk management programs bad on reducing program risks and costs. We also reviewed management controls as they applied to the audit objectives.

  10. Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

  11. Defense Meteorological Satellite Program (DMSP) Film

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The United States Air Force Defense Meteorological Satellite Program (DMSP) Operational Linescan System (OLS) is a polar orbiting meteorological sensor with two...

  12. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2013-03-01

    Radios, Joint Land Attack Cruise Missile Defense Elevated Netter Sensor System, C-130 Avionics Modernization Program, or National Polar-orbiting...investigation of hypoxia-like physiological symptoms experienced by some F- 22A pilots, an issue identified as being significant starting in 2008 and

  13. The Application of TC_DP6 in "R" Parameter Programming%参数值 TC_DP6在“R”参数编程中的应用

    Institute of Scientific and Technical Information of China (English)

    许云飞

    2012-01-01

    This paper combined Outlines pour circle and chamfering "R" parameter programming variable operation, and used specific examples to illustrate how to TC_DP6 Sin program gives compensation for the tool radius of the specific method of use value, and provided corresponding reference programs, has a certain significance on the NC programming.%本文结合轮廓倒圆与倒角“R”参数编程的变量运算,运用具体实例来说明 TC_DP6在程序中如何赋予刀具半径补偿值的具体使用方法,并给出了相应的参考程序,对数控编程具有一定的借鉴意义。

  14. Affordability of Defense Acquisition Programs

    Science.gov (United States)

    2015-02-01

    2 The study team constructed a representation of the Army investment program and plans through fiscal year 2030 using...shares are used to project resources available in each category through approximately 2030 . By fixing the topline at the level of the end of the...scenario development that takes place in the Analytic Agenda process. In that context, the Assessment Division (N-81) in the Office of the Chief of 31

  15. 76 FR 5729 - Department of Defense Personnel Security Program (PSP)

    Science.gov (United States)

    2011-02-02

    ... of the Secretary 32 CFR Part 156 Department of Defense Personnel Security Program (PSP) AGENCY... for the Department of Defense (DoD) Personnel Security Program (PSP) in accordance with the provisions... Department of Defense Directive (DoDD) 5200.2, Personnel Security Program (PSP), codified at 32 CFR 156,...

  16. 78 FR 25853 - Defense Logistics Agency Privacy Program

    Science.gov (United States)

    2013-05-03

    ... of the Secretary 32 CFR Part 323 RIN 0790-AI86 Defense Logistics Agency Privacy Program AGENCY: Defense Logistics Agency, DoD. ACTION: Final rule. SUMMARY: The Defense Logistics Agency (DLA) is revising... Defense Logistics Agency's implementation of the Privacy Act of 1974, as amended. In addition, DLA...

  17. 77 FR 46653 - Defense Logistics Agency Privacy Program

    Science.gov (United States)

    2012-08-06

    ... of the Secretary 32 CFR Part 323 RIN 0790-AI86 Defense Logistics Agency Privacy Program AGENCY: Defense Logistics Agency, DoD. ACTION: Proposed rule with request for comments. SUMMARY: The Defense Logistics Agency (DLA) is proposing to amend the DLA Privacy Program Regulation. The DLA Privacy...

  18. Defense Institution Reform Initiative Program Elements Need to Be Defined

    Science.gov (United States)

    2012-11-09

    DSCA Defense Security Cooperation Agency DASD PSO Deputy Assistant Secretary of Defense for MoDA Ministry of Defense Advisors Partnership Strategy...to the USD(P) Chief of Staff. 2 According to the DASD PSO, his office provided program management for the MoDA Program. However, according to a DASD

  19. Second Line of Defense Spares Program Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, Dale L.; Muller, George; Mercier, Theresa M.; Brigantic, Robert T.; Perkins, Casey J.; Cooley, Scott K.

    2012-11-20

    The Office of the Second Line of Defense (SLD) is part of the Department of Energy‘s (DOE) National Nuclear Security Administration (NNSA). The SLD Program accomplishes its critical global security mission by forming cooperative relationships with partner countries to install passive radiation detection systems that augment traditional inspection and law enforcement measures by alerting border officials to the presence of special nuclear or other radiological materials in cross-border traffic. An important tenet of the program is to work collaboratively with these countries to establish the necessary processes, procedures, infrastructure and conditions that will enable them to fully assume the financial and technical responsibilities for operating the equipment. As the number of operational deployments grows, the SLD Program faces an increasingly complex logistics process to promote the timely and efficient supply of spare parts.

  20. Second Line of Defense Spares Program

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, Dale L.; Holmes, Aimee E.; Muller, George; Mercier, Theresa M.; Brigantic, Robert T.; Perkins, Casey J.; Cooley, Scott K.; Thorsen, Darlene E.

    2012-11-20

    During Fiscal Year 2012, a team from the Pacific Northwest National Laboratory (PNNL) conducted an assessment and analysis of the Second Line of Defense (SLD) Sustainability spare parts program. Spare parts management touches many aspects of the SLD Sustainability Program including contracting and integration of Local Maintenance Providers (LMP), equipment vendors, analyses and metrics on program performance, system state of health, and maintenance practices. Standardized spares management will provide better data for decisions during site transition phase and will facilitate transition to host country sustainability ownership. The effort was coordinated with related SLD Sustainability Program initiatives, including a configuration items baselining initiative, a metrics initiative, and a maintenance initiative. The spares study has also led to pilot programs for sourcing alternatives that include regional intermediate inventories and partnering agreements that leverage existing supply chains. Many partners from the SLD Sustainability program contributed to and were consulted in the course of the study. This document provides a description of the findings, recommendations, and implemented solutions that have resulted from the study.

  1. Department of Defense DOD Freedom of Information Act Program

    Science.gov (United States)

    1998-09-01

    processor in previous example. WHITE, Sally 400 .2 Processed FOIA’s part-time while working as paralegal in General Counsel’s Office. PETERS, 1,000 .5 Part...Under Secretary of Defense (Industrial Affairs & Installations) Assistant to the Secretary of Defense (Nuclear, Chemical & Biological Defense Programs

  2. Department of Defense Management of Unobligated Funds for Acquisition Programs

    Science.gov (United States)

    2015-04-30

    CGFM, MBA, Senior Staff Accountant, Office of the Under Secretary of Defense (Comptroller), Financial Improvement and Audit Readiness (FIAR), 703...This research analyzes financial obligation rates for acquisition programs and acquisition program contract awards made in the last quarter of the...Postgraduate School since September 2010. Prior to that, he taught acquisition and business, cost estimating, and financial management courses at the Defense

  3. Defense Acquisitions: Assessment of Institute for Defense Analyses C-130 Avionics Modernization Program Analysis

    Science.gov (United States)

    2014-05-29

    Page 1 GAO-14-547R C-130 Avionics Modernization Program 441 G St. N.W. Washington, DC 20548 May 29, 2014...Congressional Committees Defense Acquisitions: Assessment of Institute for Defense Analyses’ C-130 Avionics Modernization Program Analysis The Air...Force’s C-130 Avionics Modernization Program (AMP), which entered development in 2001, was to standardize and upgrade the cockpit and avionics for

  4. Department of Defense Chemical and Biological Defense Program. Volume 2: FY2002-2004 Performance Plan

    Science.gov (United States)

    2003-04-01

    Complete research studies for the development of vaccine candidates for WEE virus. Defense Advanced Research Projects Agency (DARPA) Program...encephalitic alphaviruses. Continue research for the development of vaccine candidates for EEE virus infection. Test promising vaccine candidates for

  5. Defense programs beryllium good practice guide

    Energy Technology Data Exchange (ETDEWEB)

    Herr, M.

    1997-07-01

    Within the DOE, it has recently become apparent that some contractor employees who have worked (or are currently working) with and around beryllium have developed chronic beryllium disease (CBD), an occupational granulomatous lung disorder. Respiratory exposure to aerosolized beryllium, in susceptible individuals, causes an immunological reaction that can result in granulomatous scarring of the lung parenchyma, shortness of breath, cough, fatigue, weight loss, and, ultimately, respiratory failure. Beryllium disease was originally identified in the 1940s, largely in the fluorescent light industry. In 1950, the Atomic Energy Commission (AEC) introduced strict exposure standards that generally curtailed both the acute and chronic forms of the disease. Beginning in 1984, with the identification of a CBD case in a DOE contractor worker, there was increased scrutiny of both industrial hygiene practices and individuals in this workforce. To date, over 100 additional cases of beryllium-specific sensitization and/or CBD have been identified. Thus, a disease previously thought to be largely eliminated by the adoption of permissible exposure standards 45 years ago is still a health risk in certain workforces. This good practice guide forms the basis of an acceptable program for controlling workplace exposure to beryllium. It provides (1) Guidance for minimizing worker exposure to beryllium in Defense Programs facilities during all phases of beryllium-related work, including the decontamination and decommissioning (D&D) of facilities. (2) Recommended controls to be applied to the handling of metallic beryllium and beryllium alloys, beryllium oxide, and other beryllium compounds. (3) Recommendations for medical monitoring and surveillance of workers exposed (or potentially exposed) to beryllium, based on the best current understanding of beryllium disease and medical diagnostic tests available. (4) Site-specific safety procedures for all processes of beryllium that is likely to

  6. Defense Meteorological Satellite Program (DMSP) - Space Weather Sensors

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Defense Meteorological Satellite Program (DMSP) maintains a constellation of sun-synchronous, near-polar orbiting satellites. The orbital period is 101 minutes...

  7. Review of Sandia National Laboratories - Albuquerque New Mexico DOE/DP Critical Skills Development Progrmas FY04.

    Energy Technology Data Exchange (ETDEWEB)

    Gorman, Anna K; Wilson, Dominique; CLARK, KATHERINE

    2005-09-01

    Sandia National Laboratories has developed a portfolio of programs to address the critical skills needs of the DP labs, as identified by the 1999 Chiles Commission Report. The goals are to attract and retain the best and the brightest students and transition them into Sandia - and DP Complex - employees. The US Department of Energy/Defense Programs University Partnerships funded ten laboratory critical skills development programs in FY04. This report provides a qualitative and quantitative evaluation of these programs and their status. 3

  8. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2015-03-01

    Assessment 56 Figure 13: Examples of Knowledge Scorecards 58 Contents Page v GAO-15-342SP Assessments of Selected Weapon Programs Abbreviations...efficiencies realized through contract negotiations (13 programs), • design trades to balance affordability and capability (10 programs), • changed...at the time of our review with a scorecard and narrative summary at the bottom of the first page of each assessment. As illustrated in figure 12

  9. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2016-03-01

    of contractors delivering the 10 costliest programs have performed well relative to broad-based market indices, indicating that investors expect...16-329SP Assessments of Major Weapon Programs Two programs—the B-2 Extremely High Frequency Satellite Communications and Computer...expected. The B-2 Extremely High Frequency Satellite Communications and Computer Increment 1 date was revised to reflect the actual delivery of

  10. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2017-03-01

    Missile Submarine (SSBN 826) 117 Ship to Shore Connector Amphibious Craft (SSC) 119 VH-92A Presidential Helicopter Replacement Program 121... Sight Terminals (FAB-T) 143 Global Positioning System III (GPS III) 145 KC-46 Tanker Modernization Program (KC-46A) 147 Military GPS User Equipment...been incorporated into the DOD Instruction 5000.02. These and other reforms address sound management practices, such as realistic cost estimating

  11. Theater Ballistic Missile Defense Policy, Missions and Programs: Current Status

    Science.gov (United States)

    2007-11-02

    destroy its target. A French-Italian program called SAMP/T (Sol-Air Moyenne Portee/ Terrestre ) is being considered for a point defense system; further...Patriot PAC-3 missile. The Multimode Missile includes semi-active track- via -missile guidance, improved propulsion and uses an aimed blast

  12. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2008-03-01

    108Program Performance (fiscal year 2008 dollars in millions) Figures shown are based on the December 2006 Selected Acqusition Report and do not reflect... language to permit it to contract for quantities of WIN-T Increment 1 nodes in fiscal year 2008 to support operational needs, even if prior to the

  13. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2014-03-01

    a new initiative to reduce complexity within the cryptography required to encrypt and decrypt communications. In last year’s assessment, the program...TRL) 6. Demonstration in a realistic environment is TRL 7. See app . V for detailed description of TRLs. Page 27 GAO-14-340SP Assessments of

  14. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2011-03-01

    cover the JPALS ship system-radio, antenna, receiver, racks , and console. The program also tracks requirement changes to monitor design stability...with stowage cradle) and berthing modules around the LCS 2 mission bay. Navy officials also report that testing of LCS 2’s twin- boom extensible

  15. Review of Defense Display Research Programs

    Science.gov (United States)

    2001-01-01

    Programs Flat Panel Autostereoscopic N-perspective 3D High Definition DMD Digital Projector Light Piping & Quantum Cavity Displays Solid State Laser...Megapixel Displays • Size Commonality • 67 % Weight Reduction • > 200 sq. in. per Display 20-20 Vision Simulators True 3D , sparse symbols Foldable Display...megapixel 2D and True 3D Display Technology 25M & T3D FY02-FY06 New service thrusts

  16. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2017-03-01

    more stable. However, the portfolio increased its buying power by $10.7 billion— meaning DOD is able to buy more goods or services for the same... experience cost and schedule overruns. GAO continues to emphasize the need for DOD and Congress to hold programs accountable by ensuring that they...Alternatively a program’s cost can decrease due to a reduction in quantity and may still experience a buying power gain or loss. Table 2 shows our

  17. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2012-03-01

    Inc 3 Soldier Network Extension WIN-T Inc 3 Tact i lca Communications Node (While Mobile) Program/development start (7/03) Low-rate decision (4/15...Davidson, Ramzi N. Nemo Littoral Combat Ship (LCS) Rebecca A. Wilson, Molly W. Traci Littoral Combat Ship–Mission Modules Laurier R. Fish , Mya Dinh...Warfighter Information Network-Tactical (WIN-T) Increment 2 James P. Tallon, Laurier R. Fish Warfighter Information Network-Tactical (WIN-T) Increment 3

  18. FY 1972-1976 Defense Program and the 1972 Defense Budget.

    Science.gov (United States)

    1971-03-01

    Thai Government. This assessment was given me by Thai officials during my recent visit there. Insurgents along the Thai/ Malaysian border are under the...Development and Initial Procurement of Maverick Air-to-Ground Missile 31 87 Air Superiority and Air Defense Continued Procurement of F-4 Air Force Fighter... MAVERICK . The MAVERICK is another program that is of importance in providing increased capabilities for support of troops on the battlefield. MAVERICK is

  19. Department of Defense Chemical and Biological Defense Programs. Annual Report to Congress 2007

    Science.gov (United States)

    2007-04-01

    challenges. (see Figure 1.) The program depends on support in three priority areas: (1) Stable funding for the Transformational Medical Technolgies ...defense, speed of mass (life and mobility ) and information, fiscal barriers, values, and attitudes. The principles of jointness and developing an...Battlefield anti-intrusion Detection System (BaiS) an/PrS9 (Fue 2QFY06) 13. mobile Detection assessment response System (mDarS) (1QFY07) 14. Joint

  20. Safer DP systems; Sikrere DP-systemer

    Energy Technology Data Exchange (ETDEWEB)

    Steensen, Anders J.

    2004-07-01

    The specialized vessels used by the offshore industry depend on dynamical positioning (DP). DP is an automatic system that keeps a ship in a given position or on a given course. Often the deviation can be quite small, less than one metre. This considerably simplifies maneuvering the vessels that operate on the sea. Norwegian maritime industry and the oil industry have contributed to the development of a simulator which makes it possible to train crew to tackle critical situations. One important application is to prevent supply ships from colliding with oil installations. About some installations, much equipment is placed on the sea floor. Anchoring a ship in the vicinity of these installations becomes virtually impossible because of the risk of hitting sensitive equipment. Thus, ships and drilling rigs must be kept in the correct position without anchoring. The method is known from aviation.

  1. An Analysis of the Relationship Between the Professionalism of Defense Acquisition Program Managers and Program Outcomes

    Science.gov (United States)

    2011-11-30

    for example, Fox & Miller, 2006; Kronenberg , 1990) have noted the high level of complexity in defense acquisition programs. Several interviewees in...CA: Berrett–Koehler. Kronenberg , P. S. (1990). Public administration and the Defense Department: Examination of a prototype. In G. Wamsley et al

  2. Analysis to Support Execution of the Defense Environmental International Cooperation (DEIC) Program

    Science.gov (United States)

    2012-05-01

    IDA Document D-4605 May 2012 Analysis to Support Execution of the Defense Environmental International Cooperation ( DEIC ) Program Susan L. Clark...Execution of the Defense Environmental International Cooperation ( DEIC ) Program Susan L. Clark-Sestak iii Executive Summary The Defense...Environmental International Cooperation ( DEIC ) program is managed by the Director of Environmental Readiness and Safety (ERS) in the Office of the Deputy

  3. Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 5. Governmental Responsibilities for Civil Defense.

    Science.gov (United States)

    Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

    A description of the laws and orders that provide necessary legal authorization for civil defense activities is provided. In addition, an outline of the responsibilities of all governments and the role of the private sector in civil defense is presented. Topics discussed include: (1) Legal authority for civil defense, (2) Civil defense…

  4. Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 1. Civil Defense - Protection Against What?

    Science.gov (United States)

    Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

    An explanation of the need for civil defense in nuclear and natural disasters is presented. A brief historical background of civil defense is given. Major topics include: (1) Types of disasters, (2) Probable objectives of a nuclear attack on the United States, (3) The major defensive measures against a nuclear attack, (4) Some reasons for low…

  5. 77 FR 62469 - Defense Logistics Agency Freedom of Information Act Program

    Science.gov (United States)

    2012-10-15

    ..., Wright-Patterson AFB, Ohio-- Editing/routing of logistics transactions, network interoperability and e... of the Secretary 32 CFR Part 300 Defense Logistics Agency 32 CFR Part 1285 RIN 0790-AI87 Defense Logistics Agency Freedom of Information Act Program AGENCY: Defense Logistics Agency, DoD. ACTION: Proposed...

  6. SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 38 (April 2009)

    OpenAIRE

    2009-01-01

    This April 2009 issue of the Naval Postgraduate School (NPS) Maritime Defense and Security Research Program Newsletter highlights the following research: "Join MDA [Maritime Defense and Awareness] Outreach on ODNI [Office of the Director of National Intelligence] Bridge" and "NPS Cooperative Operations and Applied Science & Technology Studies." It also provides links to future events, reports, articles, and NPS Theses regarding maritime defense and security.

  7. Defense High-Level Waste Leaching Mechanisms Program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Mendel, J.E. (compiler)

    1984-08-01

    The Defense High-Level Waste Leaching Mechanisms Program brought six major US laboratories together for three years of cooperative research. The participants reached a consensus that solubility of the leached glass species, particularly solubility in the altered surface layer, is the dominant factor controlling the leaching behavior of defense waste glass in a system in which the flow of leachant is constrained, as it will be in a deep geologic repository. Also, once the surface of waste glass is contacted by ground water, the kinetics of establishing solubility control are relatively rapid. The concentrations of leached species reach saturation, or steady-state concentrations, within a few months to a year at 70 to 90/sup 0/C. Thus, reaction kinetics, which were the main subject of earlier leaching mechanisms studies, are now shown to assume much less importance. The dominance of solubility means that the leach rate is, in fact, directly proportional to ground water flow rate. Doubling the flow rate doubles the effective leach rate. This relationship is expected to obtain in most, if not all, repository situations.

  8. Defense programs industrial partnerships at Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Freese, K.B. [Los Alamos National Lab., NM (United States). Industrial Partnership Office

    1996-10-01

    The US Department of Energy`s Defense Programs face unprecedented challenges of stewardship for an aging nuclear stockpile, cessation of nuclear testing, reduced federal budgets, and a smaller manufacturing complex. Partnerships with industry are essential in developing technology, modernizing the manufacturing complex, and maintaining the safety and reliability of the nation`s nuclear capability. The past decade of federal support for industrial partnerships has promoted benefits to US industrial competitiveness. Recent shifts in government policy have re-emphasized the importance of industrial partnerships in accomplishing agency missions. Nevertheless, abundant opportunities exist for dual-benefit, mission-driven partnerships between the national laboratories and industry. Experience at Los Alamos National Laboratory with this transition is presented.

  9. 76 FR 22878 - Defense Transportation Regulation, Part IV

    Science.gov (United States)

    2011-04-25

    ... Command (USTRANSCOM), DoD. ACTION: Notice. SUMMARY: DOD has issued draft business rules for the electronic... electronic payments for NTS at all Military Services and Coast Guard installations is the goal of the Defense Personal Property Program (DP3). The initial rollout of the TPPS and the electronic payment process for...

  10. Analysis of Defense Industry Consolidation Effects on Program Acquisition Costs

    Science.gov (United States)

    2007-12-01

    Industry Mergers. 15 April 1997. Suhan, Kensinger, Keown , and Martin , “Do Strategic Alliances Create Value,” Journal of Financial Economics, 46 2 (1997...aerospace and defense contractors (Lockheed- Martin , Northrop-Grumman, Boeing, Raytheon, and General Dynamics) (See the figures in the Appendix...overhead costs. Also in 1993, Norman R. Augustine, then CEO of Lockheed Martin , headed an effort involving other major defense industry executives

  11. Establishing a Department of Defense Program Management Body of Knowledge

    Science.gov (United States)

    1991-09-01

    Initiation, Implementation, and Termination (19:10-11). Another definition can be gained from Dr David Cleland, in his text Project Management Strategies...The Defense Systems Management College (DSMC) was established in 1971 under the direction of Deputy Secretary of Defense David Packard (5:5).. The...intelligence activities, cryptological activities, omand and control, equipment that is an integral part of a weapon or weapon system, equipment critical

  12. Who Pays for National Defense? Financing Defense Programs in the United States, 1947-2007

    Science.gov (United States)

    Heo, Uk; Bohte, John

    2012-01-01

    Past studies on military expenditures in the United States have primarily focused on the extent to which guns versus butter trade-offs are prevalent without examining this relationship in the context of how other fiscal policy tools are used to pay for defense. Using annual data from 1947-2007, this study examines the relative importance of…

  13. A Comparison of Earned Value and Earned Schedule Duration Forecast Methods on Department of Defense Major Defense Acquisition Programs

    OpenAIRE

    Bruchey, William J.

    2012-01-01

    Approved for public release; distribution is unlimited Earned value management is a project management tool that integrates project scope with cost, schedule, and performance elements for optimum project planning and control. Earned value management is required by the Department of Defense for cost and incentive type contracts equal or greater than $20 million as part of a comprehensive approach to improving critical acquisitions. It is used to forecast the programs schedule performance us...

  14. Environmental assessment of defense environmental restoration program activities on St. Lawrence Island

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The magnitude and extent of environmental impacts associated with Defense environmental Restoration Program activities at Gambell and Northeast Cape varies. The...

  15. DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.

    Science.gov (United States)

    Reddien, Peter W; Andersen, Erik C; Huang, Michael C; Horvitz, H Robert

    2007-04-01

    The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a partial loss-of-function allele of the ced-3 caspase gene. We identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death). dpl-1 encodes the C. elegans homolog of DP, the human E2F-heterodimerization partner. By testing genes known to interact with dpl-1, we identified roles in cell death for four additional genes: efl-1 E2F, lin-35 Rb, lin-37 Mip40, and lin-52 dLin52. mcd-1 encodes a novel protein that contains one zinc finger and that is synthetically required with lin-35 Rb for animal viability. dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death. We propose that the DPL-1 DP, MCD-1 zinc finger, EFL-1 E2F, LIN-35 Rb, LIN-37 Mip40, and LIN-52 dLin52 proteins act together in transcriptional regulation to promote programmed cell death.

  16. Chemical and Biological Defense Program Annual Report to Congress

    Science.gov (United States)

    2006-03-01

    state public health systems, to expand existing biosurveillance efforts, and to fund research on medical countermeasures against potential bioterror...Detection System (JBSDS) • Joint Portal Shield • Biological Identification System (BIDS) • Dry Filter Units (DFUs) Table 2-3 Biological Defense...Detection System (BIDS) • Joint Portal Shield Network Sensor System • Automated biological remote detection and early warning capabilities

  17. Department of Defense Enhanced Particulate Matter Surveillance Program (EPMSP)

    Science.gov (United States)

    2008-02-01

    relation to five rural IMPROVE sites (Dome Land NWA, Joshua Tree NP, Bosque del Apache NWR, Salt Creek, and San Andres NWR) and five urban STN sites...The five rural sites are at Dome Land National Wildlife Area (NWA), Joshua Tree National Park, Bosque del Apache National Wildlife Refuge (NWR), Salt...Department of Defense (DoD) lands in the southwestern U.S. in relation to five rural IMPROVE sites (Dome Land NWA, Joshua Tree NP, Bosque del Apache NWR

  18. Evaluation of the Department of Defense Combating Trafficking in Persons Program

    Science.gov (United States)

    2014-06-16

    DODIG-2014-079 │ 1 Introduction Prior to 2000, allegations of sexual slavery, sex with minors, and human trafficking involving U.S. contractors in...1 6 , 2 0 1 4 Evaluation of the Department of Defense Combating Trafficking in Persons Program Report No. DODIG-2014-079 Report Documentation...3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE Evaluation of the Department of Defense Combating Trafficking in Persons

  19. Identifying Enterprise Leverage Points in Defense Acquisition Program Performance

    Science.gov (United States)

    2009-09-01

    Planning Guidance SPI Schedule Efficiency SPO System Program Office SPOC Special Access Required (SAR) Programs Oversight Committee SPRG...Air Force office of Financial Management and Budget; SES = Senior Executive Service; SPOC /SPRG/SAR = classified financial review system for

  20. Defense Acquisitions: Assessments of Selected Major Weapon Programs

    Science.gov (United States)

    2006-03-01

    Common Name: C-130 AMPC -130 Avionics Modernization Program (C-130 AMP)The Air Force’s C-130 AMP standardizes the cockpit configurations and avionics for...GAO-06-391 Assessments of Selected Major Weapon Programs Common Name: C-130 AMPC -130 AMP Program Technology Maturity All of the C-130 AMP’s six...Selected Major Weapon Programs Common Name: C-5 AMPC -5 Avionics Modernization Program (C-5 AMP)The Air Force’s C-5 AMP is the first of two major upgrades

  1. Compendium of Programs to Assist the Transition. Annex G to Adjusting to the Drawdown. Report to the Defense Conversion Commission,

    Science.gov (United States)

    1993-02-01

    5235 (for civilian registrants) The Defense Outplacement Referral System (DORS). The DORS is an automated registry of "mini-resumes" of military...identifying employers who are interested in hiring former Army personnel. The existing DoD databanks, such as the Defense Outplacement Referral...Training Partnership Act Ine Secretary of Defense may coordinate this program with the Defense Outplacement Referral System (DORS) and other automated job

  2. Department of Defense Biological Defense Program Needs for Strategic Biotechnology Development

    Science.gov (United States)

    2013-05-16

    Command and Control 4 Bacteria /Rickettsia Viruses Toxins Anthrax Smallpox Botulinum Brucellosis Rift Valley Fever Ricin Cholera Crimean-Congo SEB Plague...structural biology − Establish research programs in aerobiological research, forensic genomics and certified forensic biological threat agent capability

  3. Implementation and Sustainability of the Russian Federation Ministry of Defense Nuclear Personnel Reliability Program

    Energy Technology Data Exchange (ETDEWEB)

    LataPhD, Vasiliy [Aspect Conversion; Coates, Cameron W [ORNL

    2010-01-01

    Through a cooperative effort between the US Department of Energy and the Russian Federation (RF) Ministry of Defense (MOD) a Personnel Reliability Program (PRP) for the nuclear handlers within the RF MOD is at the stage of implementation. Sustaining the program is of major significance for long term success. This paper will discuss the elements of the RF PRP and the equipment needs for implementation. Program requirements, documentation needs, training, and assurances of appropriate equipment use will be addressed.

  4. Digging Out the Root Cause: Nunn-McCurdy Breaches in Major Defense Acquisition Programs

    Science.gov (United States)

    2014-04-30

    Acquisition Programs Bill Shelton, RAND Corporation Irv Blickstein, RAND Corporation Jerry Sollinger, RAND Corporation Charles Nemfakos, RAND...to become a research sponsor, or to print additional copies of reports, please contact any of the staff listed on the Acquisition Research Program...Out the Root Cause: Nunn-McCurdy Breaches in Major Defense Acquisition Programs Bill Shelton, RAND Corporation Irv Blickstein, RAND Corporation

  5. Department of Defense Chemical and Biological Defense Program. Volume 1: Annual Report to Congress

    Science.gov (United States)

    2003-04-01

    Program Annual Report E-46 • Cloned and sequenced regions of the polymerase gene (E9L) from 35 variola isolates, as well as cidofovir -resistant...IC50) of cidofovir and 3-hexadecyloxy-1- propanol (HDP)- cidofovir against 40 strains of variola, monkeypox, cowpox, and vaccinia. All viruses... cidofovir in vitro against a panel of orthopoxviruses at USAMRIID and variola at the Centers for Disease Control and Prevention (CDC). Determined that

  6. FY 1975 Defense Budget and FY 1975-1979 Defense Program

    Science.gov (United States)

    1975-01-01

    ecological , or biological dangers to the area in which it is installed. 77 L The need for a more survivable communications link to our ballistic...Ship 32 61 58 Acquisition of Patrol Hydrofoil Missile Ship 30 23 108 Anti-Ship Missiles Acquisition of the HARPOON Anti-Ship Missile 60 81 136...force will be augmented by the first two of a new class of Patrol Hydrofoil Missile ships (PHM). The PHM is a cooperative NATO development program in

  7. Implementing Effective Affordability Constraints for Defense Acquisition Programs

    Science.gov (United States)

    2014-03-01

    between 1999 and 2009. Since several of those programs advertised themselves as employing the CAIV concept, the IDA team was able to draw on that...and mutable to yield to stereotyped or routinized processes. The processes associated with CAIV are tools that can help achieve powerful results if...Vehicle (EELV). Each of these FPPs, as well as four other prominent programs that advertised use of CAIV, will be reviewed in this appendix to help to

  8. Regulatory Burden and Poor Defense Acquisition Program Outcomes

    Science.gov (United States)

    2014-05-01

    drive program improvements • Econometric modeling lesson is that this is opportunity for better understanding of cause, effect, and explanation of...Agenda • Overview • Previous Work • Method • Data • Models • Results • Interpretation • Conclusions • Future Work © 2014 by the University of Tennessee...regulation or reforms? – Previously modeled as the correlation and direction of change for a key performance metric for a program in the years following the

  9. SDI (Strategic Defense Initiative) Software Technology Program Plan

    Science.gov (United States)

    1987-06-01

    Computing Initiative program under Simpson and Sears . Industrial research labs are studying fundamental issues of the man-machine interface to formulate...Reform," The Brookings Review, Summer 1986, pp. 11-16. [Maidique 80] Maidique, Modesto , "Entrepreneurs, Champions, and % Technological Innovation...Management Tasks Area," from Computer t. Special Issue on STARS Program, (November 1983), pp. 56-62. [Maidique 80] Maidique, Modesto A., "Entrepreneurs

  10. The Need for Reforming the Department of Defense Retirement Program

    Science.gov (United States)

    2010-06-04

    year vestment and immediate annuity is one of the best pension program available to a non-disabled employee in America. No other governmental of civil... pension programs have the potential to provide a retirement annuity for twice as long as the employment status. Even at a portion of the employment...such a way that is fair to current and retired service members it must grandfather the basic annuity . Furthermore, failure to act now will only delay

  11. 76 FR 55883 - Department of Defense Program for Construction, Renovation, Repair or Expansion of Public Schools...

    Science.gov (United States)

    2011-09-09

    ....'' OEA is establishing a one-time non-competitive program, as described in this notice, to administer... Secretary of Defense for Personnel and Readiness, attention: Russell Roberts, Chief, Logistics Division..., and to structure proposals to take best advantage of other contributions. OEA may waive part or...

  12. Defense Small Business Innovation Research Program (SBIR). Abstracts of Phase I Awards. 1985.

    Science.gov (United States)

    1985-01-01

    34CANNED" PROGRAM. THE SYNERGY OF HELICAL SCAN AND CGI IS A TECHNICAL ADVANTAGE BY CON- CENTRATING THE PERCEIVED INFORMATION IN THE ROBOT PICK-UP RASTER...COUNT * NEEDED FOR THE CALCULATION. * NW SYSTEMS SDIO $ 0 36 PANORAMA TRAIL ROCHESTER, NY 14525 DR CAROL A NIZNIK TITLE: STRATEGIC DEFENSE DATA BASE

  13. Modeling an integrative physical examination program for the Departments of Defense and Veterans Affairs.

    Science.gov (United States)

    Goodrich, Scott G

    2006-10-01

    Current policies governing the Departments of Defense and Veterans Affairs physical examination programs are out of step with current evidence-based medical practice. Replacing periodic and other routine physical examination types with annual preventive health assessments would afford our service members additional health benefit at reduced cost. Additionally, the Departments of Defense and Veterans Affairs repeat the physical examination process at separation and have been unable to reconcile their respective disability evaluation systems to reduce duplication and waste. A clear, coherent, and coordinated strategy to improve the relevance and utility of our physical examination programs is long overdue. This article discusses existing physical examination programs and proposes a model for a new integrative physical examination program based on need, science, and common sense.

  14. Defense Surplus Equipment Disposal, Including the Law Enforcement 1033 Program

    Science.gov (United States)

    2014-09-05

    Helicopters 7- High Mobility Multipurpose Vehicles 2 -Night vision equipment 2 - Robots Other general property Firefighting Support Program Title...to the Secretary of Agriculture and the Secretary of Homeland Security for use by the Forest Service and the U.S. Coast Guard.31 P.L. 112-81 (H.R

  15. Defense Acquisition University (DAU) Program Managers Tool Kit

    Science.gov (United States)

    2008-03-01

    addtonal KPPs are requred for selected programs: system tranng and energy effic ency. • The MDA may add other sgnficant performance parameters...plans and other AT&L products accurately and effic ently. The followng PPLTs have been developed: • Prcng Support Tool <http://prcngtool.dau.ml

  16. Defense Manufacturing Management Guide for Program Managers, Third Edition

    Science.gov (United States)

    1989-04-01

    they speak to the utility of the product actions such as recalls. In the military in its end use environment. The degree to environment, there Is...represent goals. In speaking , the higher the rate, the lower the practice, contractors usually produce, and unit production cost. program management offices...referred to as computer 4. Obtain from current users: numerical control (CNC). Such a system a. Level of operator skiil usually containL a large

  17. A Best Practices Based Approach to Major Defense Acquisition Programs

    Science.gov (United States)

    2010-04-26

    EBSCO . Web. 10 Apr. 2010. Heberling, Michael E. "Open Issues in Acquisition Reform. 11 National Contract Management Journal27.2 (1996): 43-58...1325-1326. America: History & Life. EBSCO . Web. 10 Apr. 2010. Kraft, Jonathan. 11 The Evolution of Program Budgeting in the United States Government...34 Armed Forces Comptroller 54.1 (2009): 40-41. International Security & Counter Terrorism Reference Center. EBSCO . Web. 11 Apr. 2010. Li, Allen

  18. Defense Transportation’s EDI Program: A Security Risk Assessment

    Science.gov (United States)

    1993-05-01

    available when needed. One way to provide proof of system-security procedures is to follow the guide- lines in the Inteinal Management Control Program ( IMCP ...as mandated by the Federal Manager’s Financial Integrity Act (FMFIA). The IMCP prescribes both general and specific standards for maintaining...appropriate internal controls. For 12 example, the IMCP states that control systems shall be properly documented, trans- actions and other significant

  19. Defense Standardization Program Journal. April/June 2011

    Science.gov (United States)

    2011-06-01

    I he system was designed with a standard global positioning systems small serial interface, required (o lisp ilia mil meet MIL-STD-461...Savings related to this effort are on the order ot $14.5 million. lisp ilia mil Standardization has been further advanced by researching part number...from sand erosion lisp illu mil Program News I Navy-led team, for developing a Joint Counter Radio-Controlled Improvised Ex- plosive Device (IED

  20. Schedule-Driven Costs in Major Defense Programs

    Science.gov (United States)

    2012-04-30

    Systems  Army Contracting Command, U.S. Army Materiel Command ^Åèìáëáíáçå=oÉëÉ~êÅÜ=moldo^jW= `êÉ~íáåÖ=póåÉêÖó=Ñçê=fåÑçêãÉÇ=`Ü~åÖÉ= -= ii ...in World War II in the rapid mobilization of the industrial base to provide the number of needed vehicles for the war. On the other hand, programs...and standardized integrated master schedules (IMS) using the principles of the Generally Accepted Scheduling Practices ( GASP ). The guide emphasizes

  1. National Defense: Department of Defense’s Waiver of Competitive Prototyping Requirement for the Navy’s Fleet Replenishment Oiler Program

    Science.gov (United States)

    2014-10-08

    Defense: Department of Defense’s Waiver of Competitive Prototyping Requirement for the Navy’s Fleet Replenishment Oiler Program The Weapon Systems...Department of Defense’s Waiver of Competitive Prototyping Requirement for the Navy’s Fleet Replenishment Oiler Program 5a. CONTRACT NUMBER 5b. GRANT...15, 2014, we received notice from DOD that it had waived the competitive prototyping requirement for the Fleet Replenishment Oiler (T-AO(X)) program

  2. Analysis of System Training Impact for Major Defense Acquisition Programs (MDAPs): Training Systems Acquisition

    Science.gov (United States)

    2012-07-01

    evidenced in our other case studies. However, with the rapid production and deployment of the vehicles in 2007–2008, the operators began to experience...Background The Patriot system began because of the need to replace an aging and limited air defense system in the 1970s, the Nike -Hercules, and...The program sponsors of the Patriot also desired to take advantage of technological innovation and information superiority to enhance overall

  3. Managing the Service Supply Chain in Department of Defense: Implications for the Program Management Infrastructure

    Science.gov (United States)

    2007-04-30

    Supply Chain in Department of Defense: Implications for the Program Management Infrastructure Published: 30 April 2007 by Rene G. Rendon, Lecturer, and Uday Apte, Professor, Naval Postgraduate School 4th Annual Acquisition Research Symposium of the Naval Postgraduate School: Approved for public release, distribution unlimited. Prepared for: Naval Postgraduate School, Monterey, California 93943 Acquisition Research: Creating Synergy for Informed Change May 16-17, 2007 Report Documentation Page Form ApprovedOMB No. 0704-0188

  4. FY 1978 Budget, FY 1979 Authorization Request and FY 1978-1982 Defense Programs,

    Science.gov (United States)

    1977-01-17

    petroleum comes from external sources, and more than 33 percent of that total is imported from the Persian Gulf. We draw on tin from Malaysia , Thailand and...This system, supporting laser-guided, modular glide bombs or a forward- fired weapon such as the Maverick guided missile, will provide improved...program. An additional 900 Shrike antiradiation missiles are being procured for defense suppression tasks. Some 100 laser-guided Maverick ground attack

  5. A self-defense program reduces the incidence of sexual assault in Kenyan adolescent girls.

    Science.gov (United States)

    Sinclair, Jake; Sinclair, Lee; Otieno, Evans; Mulinge, Munyae; Kapphahn, Cynthia; Golden, Neville H

    2013-09-01

    To determine the effect of a standardized 6-week self-defense program on the incidence of sexual assault in adolescent high school girls in an urban slum in Nairobi, Kenya. Population-based survey of 522 high school girls in the Korogocho-Kariobangi locations in Nairobi, Kenya, at baseline and 10 months later. Subjects were assigned by school attended to either a "No Means No Worldwide" self-defense course (eight schools; N = 402) or to a life-skills class (two schools; N = 120). Both the intervention and the life-skills classes were taught in the schools by trained instructors. Participants were administered the same survey at baseline and follow-up. A total of 522 girls (mean age, 16.7 ± 1.5 years; range, 14-21 years) completed surveys at baseline, and 489 at 10-month follow-up. At baseline, 24.5% reported sexual assault in the prior year, with the majority (90%) reporting assault by someone known to them (boyfriend, 52%; relative, 17%; neighbor, 15%; teacher or pastor, 6%). In the self-defense intervention group, the incidence of sexual assault decreased from 24.6% at baseline to 9.2% at follow-up (p < .001), in contrast to the control group, in which the incidence remained unchanged (24.2% at baseline and 23.1% at follow-up; p = .10). Over half the girls in the intervention group reported having used the self-defense skills to avert sexual assault in the year after the training. Rates of disclosure increased in the intervention group, but not in controls. A standardized 6-week self-defense program is effective in reducing the incidence of sexual assault in slum-dwelling high school girls in Nairobi, Kenya. Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  6. HEK293 cells express dystrophin Dp71 with nucleus-specific localization of Dp71ab.

    Science.gov (United States)

    Nishida, Atsushi; Yasuno, Sato; Takeuchi, Atsuko; Awano, Hiroyuki; Lee, Tomoko; Niba, Emma Tabe Eko; Fujimoto, Takahiro; Itoh, Kyoko; Takeshima, Yasuhiro; Nishio, Hisahide; Matsuo, Masafumi

    2016-09-01

    The dystrophin gene consists of 79 exons and encodes tissue-specific isoforms. Mutations in the dystrophin gene cause Duchenne muscular dystrophy, of which a substantial proportion of cases are complicated by non-progressive mental retardation. Abnormalities of Dp71, an isoform transcribed from a promoter in intron 62, are a suspected cause of mental retardation. However, the roles of Dp71 in human brain have not been fully elucidated. Here, we characterized dystrophin in human HEK293 cells with the neuronal lineage. Reverse transcription-PCR amplification of the full-length dystrophin transcript revealed the absence of fragments covering the 5' part of the dystrophin cDNA. In contrast, fragments covering exons 64-79 were present. The Dp71 promoter-specific exon G1 was shown spliced to exon 63. We demonstrated that the Dp71 transcript comprised two subisoforms: one lacking exon 78 (Dp71b) and the other lacking both exons 71 and 78 (Dp71ab). Western blotting of cell lysates using an antibody against the dystrophin C-terminal region revealed two bands, corresponding to Dp71b and Dp71ab. Immunohistochemical examination with the dystrophin antibody revealed scattered punctate signals in the cytoplasm and the nucleus. Western blotting revealed one band corresponding to Dp71b in the cytoplasm and two bands corresponding to Dp71b and Dp71ab in the nucleus, with Dp71b being predominant. These results indicated that Dp71ab is a nucleus-specific subisoform. We concluded that Dp71, comprising Dp71b and Dp71ab, was expressed exclusively in HEK293 cells and that Dp71ab was specifically localized to the nucleus. Our findings suggest that Dp71ab in the nucleus contributes to the diverse functions of HEK293 cells.

  7. Survey of Laboratories and Implementation of the Federal Defense Laboratory Diversification Program

    Science.gov (United States)

    1994-02-01

    Defense Technology Transfer Working Group AGENCY...Director, Defense Research and Engineering. ACTION: solicitation in inputs for defense technology transfer . The Defense Technology Transfer Working...DAILY, 2.3 July 1993 Detense Nuclear Agency, 6801 Telegraph Road, Alexandria,, VA 22310D-3398 A - SOURCES SOUGHT FOR INPUTS FOR DEFENSE TECHNOLOGY TRANSFER

  8. DFT STUDIES OF DP-3 AMYLOSE FRAGMENTS

    Science.gov (United States)

    This study extends our work on mono- and disaccharides to structures with three glucose residues by two alpha-[1-4] bridges, denoted herein as DP-3's. DFT optimization studies of DP-3 fragments have been carried out at the B3LYP/6-311++G** level of theory. Different hydroxymethyl conformations (gg...

  9. Radar Detection for Dim Moving Target Using DP Algorithm

    Institute of Scientific and Technical Information of China (English)

    MOLi; WUSiliang; MAOErke

    2004-01-01

    A lot of work has been done for applying Dynamic programming (DP) algorithm in weak moving target detection and tracking. Most of them are based on IR image sequence and a constant target velocity is assumed. The goal of this paper is to apply DP algorithm to radar Doppler detection problems. Radar returns from multiple range cells are arranged as a set of Doppler-range images to fit in DP imagery detection model. Trajectories in image sequence are modeled as states sets. Then De algorithm is applied to integrate measurements along possible target trajectories, returning as possible targets those trajectories for which the measurement sum, or merit function, exceeds a threshold. Low SNR target that maneuvers among several range cells can be detected through such long-term integration. Under a practical set of radar parameters, good detection performances are presented that at about 10070 detection probability, about 7dB SNR gain is achieved through 15-frame DP non-coherent integration.

  10. Effects of Department of Defense Instruction 5000.02 on Joint Program Executive Office Chemical Biological Defense (JPEO-CBD) Effectiveness

    Science.gov (United States)

    2016-09-01

    Table 6 (continued) LRIP Quantity 2015 X X 2008 X Market Research 2015 X X X 2008 X X OTA Report of OT&E Results...JOINT PROGRAM EXECUTIVE OFFICE – CHEMICAL BIOLOGICAL DEFENSE (JPEO-CBD) EFFECTIVENESS September 2016 By: Emily C. Whaley Advisors...Michael Boudreau Kate Ong Approved for public release. Distribution is unlimited. THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE

  11. Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system.

    Science.gov (United States)

    Chang, Shiao-Ying; Chen, Yun-Wen; Zhao, Xin-Ping; Chenier, Isabelle; Tran, Stella; Sauvé, Alexandre; Ingelfinger, Julie R; Zhang, Shao-Ling

    2012-10-01

    We investigated whether overexpression of catalase (CAT) in renal proximal tubular cells (RPTCs) could prevent the programming of hypertension and kidney disease in the offspring of dams with maternal diabetes. Male offspring of nondiabetic and diabetic dams from two transgenic (Tg) lines (Hoxb7-green fluorescent protein [GFP]-Tg [controls] and Hoxb7/CAT-GFP-Tg, which overexpress CAT in RPTCs) were studied from the prenatal period into adulthood. Nephrogenesis, systolic blood pressure, renal hyperfiltration, kidney injury, and reactive oxygen species (ROS) generation were assessed. Gene expression of transforming growth factor-β1 (TGF-β1), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and heme oxygenase-1 (HO-1) was tested in both in vitro and in vivo studies. Renal dysmorphogenesis was observed in offspring of Hoxb7-GFP-Tg dams with severe maternal diabetes; the affected male offspring displayed higher renal ROS generation and developed hypertension and renal hyperfiltration as well as renal injury with heightened TGF-β1 expression in adulthood. These changes were ameliorated in male offspring of diabetic Hoxb7/CAT-GFP-Tg dams via the Nrf2-HO-1 defense system. CAT promoted Nrf2 nuclear translocation and HO-1 gene expression, seen in both in vitro and in vivo studies. In conclusion, CAT overexpression in the RPTCs ameliorated maternal diabetes-induced perinatal programming, mediated, at least in part, by triggering the Nrf2-HO-1 defense system.

  12. Overview of the Defense Programs Research and Technology Development Program for Fiscal Year 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This documents presents a programmatic overview and program element plan summaries for conceptual design and assessment; physics; computation and modeling; system engineering science and technology; electronics, photonics, sensors, and mechanical components; chemistry and materials; special nuclear materials, tritium, and explosives.

  13. Building Partner Capacity: DOD Should Improve Its Reporting to Congress on Challenges to Expanding Ministry of Defense Advisors Program

    Science.gov (United States)

    2015-02-11

    Ministry of Defense Advisors ( MODA ) program more slowly than planned. It had 2 advisors in the field in Kosovo and Montenegro for most of fiscal year...approval process and with advisor recruitment and training. DOD has met most but not all legislative requirements for the MODA program. As required by...of each Global MODA deployment, which could help Congress assess the value of the program in relation to other capacity-building efforts (see figure

  14. A Bacterial Inhibitor of Host Programmed Cell Death Defenses is an E3 Ubiquitin Ligase

    Energy Technology Data Exchange (ETDEWEB)

    Janjusevic,R.; Abramovitch, R.; Martin, G.; Stebbins, C.

    2005-01-01

    The Pseudomonas syringae protein AvrPtoB is translocated into plant cells, where it inhibits immunity-associated programmed cell death (PCD). The structure of a C-terminal domain of AvrPtoB that is essential for anti-PCD activity reveals an unexpected homology to the U-box and RING-finger components of eukaryotic E3 ubiquitin ligases, and we show that AvrPtoB has ubiquitin ligase activity. Mutation of conserved residues involved in the binding of E2 ubiquitin-conjugating enzymes abolishes this activity in vitro, as well as anti-PCD activity in tomato leaves, which dramatically decreases virulence. These results show that Pseudomonas syringae uses a mimic of host E3 ubiquitin ligases to inactivate plant defenses.

  15. Trends in Nunn-McCurdy Cost Breaches for Major Defense Acquisition Programs

    Science.gov (United States)

    2011-03-09

    Demilitarization - Chemical Materials Agency Bechtel National Inc., Westinghouse, Washington Demil Co., EG&G Defense Materials, Parsons Infra...Engineers & Construction, Raytheon Demil Company, Bechtel National, Inc., EG&G Defense Materials Comanche Reconnaissance Attack Helicopter Boeing

  16. Predicting Schedule Duration for Defense Acquisition Programs: Program Initiation to Initial Operational Capability

    Science.gov (United States)

    2016-03-24

    65  x Figure 22: Pie Chart of Standard Betas ... Corporation found that increases in schedule effort tend to be the reason for increases in the cost of acquiring a new weapons system due to, at a minimum...in-depth finance and schedule data for selected programs (Brown et al., 2015). We also give extra focus on Research Development Test & Evaluation

  17. Defense Infrastructure: Continuing Challenges in Managing DOD Lodging Programs as Army Moves to Privatize Its Program

    Science.gov (United States)

    2006-12-01

    4) develop and manage the lodging facilities, (5) assure sound financial management and accountability reflective of the hospitality industry , and...reflective of the hospitality industry , and (6) pursue efficiencies through interservice cooperative efforts. The DOD Lodging Program Standards task...goals. DOD lodging officials with work experience in private hotels told us that it is a common practice in the hospitality industry to use benchmarks

  18. Microfiche/Telex Oriented Document Services Center Established in Sylvania Library Through Cooperative Test Program with Defense Documentation Center.

    Science.gov (United States)

    Little, Dean K.

    In a cooperative program with Defense Documentation Center Headquarters, Sylvania arranged for procurement of 70,000 unclassified-unlimited documents without DDC Form I cards and 30,000 unclassified-limited and classified documents with Form I's. This was done in order to overcome effects of an in-house documents inventory/selective destruction…

  19. Program Manager: Journal of the Defense Systems Management College. Volume 22, Number 3, May-June 1993

    Science.gov (United States)

    1993-06-01

    lr __________ r onM eth S()4 Greg Caruth _________________ William J. Perry, Typography and Design DEPSECDEF 43 Paula Croisetlere 3 Program Manager...the DSMC Press to be such a link to the govern- for publication consideration in either the brand ment and private sector defense acquisition com- new

  20. Technology Partnership Program fiscal year 1998 program plan

    Energy Technology Data Exchange (ETDEWEB)

    Ford, R.

    1997-09-15

    The Oak Ridge Y-12 Plant will use the Technology Partnership Program to support the DOE nuclear weapons complex (NWC), particularly at the Oak Ridge Y-12 Plant. This support will be achieved through partnerships with industry that enhance the science and technology base and the core capabilities necessary to meet current and future weapons program mission needs. This program will enhance the Weapons Complex technology base and core capabilities by participating, in diversified portfolios of collaborative projects with industrial. The Y-12 Technology Partnership Program (TPP) closely aligns its program with the goals, objectives, and strategies of the DP Stockpile Stewardship and Management plans and DOE technology transfer policy. The Y-12 Defense Programs Office is the primary customer of the Y-12 TPP, and provides input to program planning and execution. Industry involvement is also an essential component. Programs and projects within the Y-12 TPP are responsive to identified weapons complex mission needs. In FY98 the Y-12 TPP will execute the plan devised during FY97 which emphasized the program`s increasing focus on providing benefits to DP. This plan called for the soft-landing of four terminated projects early in FY97 and the normal conclusion of four others at various times throughout the year. Successful conclusion of these projects enabled a call for new TPP projects in FY98 with clearer Defense Program benefits. The Defense Programs benefits were assured by the participation of Y-12`s Weapon Advisory Council, which met to determine proposal guidelines and criteria. The Weapons Advisory Council later met to rank each proposal against the established guidelines assuring those proposals with the best DP benefits would be chosen. The goal for the Y-12 TPP program will be to successfully implement the winning proposals in the first quarter of FY98 and maintain administrative and fiscal control over these and continuing projects.

  1. Technology Partnership Program fiscal year 1998 program plan

    Energy Technology Data Exchange (ETDEWEB)

    Ford, R.

    1997-09-15

    The Oak Ridge Y-12 Plant will use the Technology Partnership Program to support the DOE nuclear weapons complex (NWC), particularly at the Oak Ridge Y-12 Plant. This support will be achieved through partnerships with industry that enhance the science and technology base and the core capabilities necessary to meet current and future weapons program mission needs. This program will enhance the Weapons Complex technology base and core capabilities by participating, in diversified portfolios of collaborative projects with industrial. The Y-12 Technology Partnership Program (TPP) closely aligns its program with the goals, objectives, and strategies of the DP Stockpile Stewardship and Management plans and DOE technology transfer policy. The Y-12 Defense Programs Office is the primary customer of the Y-12 TPP, and provides input to program planning and execution. Industry involvement is also an essential component. Programs and projects within the Y-12 TPP are responsive to identified weapons complex mission needs. In FY98 the Y-12 TPP will execute the plan devised during FY97 which emphasized the program`s increasing focus on providing benefits to DP. This plan called for the soft-landing of four terminated projects early in FY97 and the normal conclusion of four others at various times throughout the year. Successful conclusion of these projects enabled a call for new TPP projects in FY98 with clearer Defense Program benefits. The Defense Programs benefits were assured by the participation of Y-12`s Weapon Advisory Council, which met to determine proposal guidelines and criteria. The Weapons Advisory Council later met to rank each proposal against the established guidelines assuring those proposals with the best DP benefits would be chosen. The goal for the Y-12 TPP program will be to successfully implement the winning proposals in the first quarter of FY98 and maintain administrative and fiscal control over these and continuing projects.

  2. The DoD Manufacturing Technology Program Strategic Plan: Delivering Defense Affordability

    Science.gov (United States)

    2009-03-01

    laboratories and RDECs to RDECOM SOSI. The first level of review for ATO-Ms is the Warfighter Technical Council ( WTC ). The WTC is a one-star level body that...and cost. Tracked efforts: this category consists of smaller stand-alone ManTech projects. Typically, the WTC approves tracked efforts...National Defense Authorization Act NDE non- destructive examination NDIA National Defense Industrial Association NDS National Defense Strategy Net

  3. 77 FR 8837 - Termination of the Department of Defense Web-Based TRICARE Assistance Program Demonstration

    Science.gov (United States)

    2012-02-15

    ... family difficulties and pressures, crisis intervention, anxiety, self-esteem, loneliness, and critical... Demonstration AGENCY: Department of Defense, DoD. ACTION: Notice of demonstration termination. SUMMARY:...

  4. THE PLANNING, PROGRAMING, BUDGETING SYSTEM AND ITS IMPLEMENTATION IN THE SERBIAN MINISTRY OF DEFENSE

    Directory of Open Access Journals (Sweden)

    Sasa RADUSKI

    2010-01-01

    Full Text Available The main purpose of introducing the PPBES to the Serbian Ministry of Defense and the Serbian Armed Forces is to provide a rational management of resources and to maintain and build capacity of the Ministry and the Serbian Armed Forces in order to achieve their goals, objectives and missions.Expected results of implementation of the PPBES are reflected in increasing the efficiency and rationalization of the defense planning to a higher level, ensuring compatibility with defense planning and budgeting system of the state and developing a foundation for the effective management of defense resources.

  5. Defense Small Business Innovation Research Program (SBIR). Volume 4. Defense Agencies Abstracts of Phase 1 Awards 1987.

    Science.gov (United States)

    1988-04-01

    CHANNEL) . THE -0 SMALL BUSINESS INNOVATION RESEARCH ( SBR ) PROGRAM - PHASE I PAGE 628 0 BY SERVICE FISCAL YEAR 1987 DNA SJBMTTFD BY NATURE OF THE...OXYGEN CONTAMINATION. THEIR HIGH PYROLYSIS TEMPERATURES CAUSE PROBLEMS SUCH AS INABILITY TO CONTROL THE AS/P RATIO IN ALLOYS CONTAINING BOTH ELEMENTS...LUBRICITY. GRAPHITE FIBER GROWN FROM PYROLYSIS OF HYDROCARBON GAS, WHICH IS THEN PROCESSED TO YIELD USEFUL VALUES FOR ELECTRICAL CONDUCTIVITY, IS A MATERIAL

  6. Restriction fragment length polymorphism of the HLA-DP subregion and correlations to HLA-DP phenotypes

    DEFF Research Database (Denmark)

    Hyldig-Nielsen, J J; Morling, Niels; Ødum, Niels;

    1987-01-01

    The restriction fragment length polymorphism (RFLP) of the class II HLA-DP subregion of the major histocompatibility complex (MHC) of humans has been unraveled by Southern blotting using DP alpha and DP beta probes in a study of 46 unrelated individuals with known HLA-DP types. Contrary to earlier...... preliminary findings with a limited number of enzymes, the RFLP appears to be quite extensive both with the DP beta (14 different DNA markers defined by individual fragments or clusters thereof) and the DP alpha (8 markers) probes, especially when enzymes recognizing only four base pairs were used. A few...

  7. Department of Defense Small Business (SB) Program: A Knowledge-Level Analysis of How Customer Education Relates to Meeting SB Goals

    Science.gov (United States)

    2014-12-01

    7 B. SMALL BUSINESS PROGRAM OVERVIEW ...........................................7 1. Women -Owned Small ...of Defense DSB Director of Small Business DTRA Defense Threat Reduction Agency EDWOSB economically disadvantaged women -owned small businesses EO...USTRANSCOM U.S. Transportation Command VOSB veteran-owned small business WMD weapons of mass destruction WOSB women -owned small business xiv

  8. Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense

    DEFF Research Database (Denmark)

    Brodersen, Peter; Petersen, Morten; Pike, Helen M

    2002-01-01

    by avirulent pathogens. Global transcriptional changes during programmed cell death (PCD) and defense activation in acd11 were monitored by cDNA microarray hybridization. The PCD and defense pathways activated in acd11 are salicylic acid (SA) dependent, but do not require intact jasmonic acid or ethylene...

  9. Hamiltonian Approach To Dp-Brane Noncommutativity

    Science.gov (United States)

    Nikolic, B.; Sazdovic, B.

    2010-07-01

    In this article we investigate Dp-brane noncommutativity using Hamiltonian approach. We consider separately open bosonic string and type IIB superstring which endpoints are attached to the Dp-brane. From requirement that Hamiltonian, as the time translation generator, has well defined derivatives in the coordinates and momenta, we obtain boundary conditions directly in the canonical form. Boundary conditions are treated as canonical constraints. Solving them we obtain initial coordinates in terms of the effective ones as well as effective momenta. Presence of momenta implies noncommutativity of the initial coordinates. Effective theory, defined as initial one on the solution of boundary conditions, is its Ω even projection, where Ω is world-sheet parity transformation Ω:σ→-σ. The effective background fields are expressed in terms of Ω even and squares of the Ω odd initial background fields.

  10. The Defense Threat Reduction Agency's Technical Nuclear Forensics Research and Development Program

    Science.gov (United States)

    Franks, J.

    2015-12-01

    The Defense Threat Reduction Agency (DTRA) Technical Nuclear Forensics (TNF) Research and Development (R&D) Program's overarching goal is to design, develop, demonstrate, and transition advanced technologies and methodologies that improve the interagency operational capability to provide forensics conclusions after the detonation of a nuclear device. This goal is attained through the execution of three focus areas covering the span of the TNF process to enable strategic decision-making (attribution): Nuclear Forensic Materials Exploitation - Development of targeted technologies, methodologies and tools enabling the timely collection, analysis and interpretation of detonation materials.Prompt Nuclear Effects Exploitation - Improve ground-based capabilities to collect prompt nuclear device outputs and effects data for rapid, complementary and corroborative information.Nuclear Forensics Device Characterization - Development of a validated and verified capability to reverse model a nuclear device with high confidence from observables (e.g., prompt diagnostics, sample analysis, etc.) seen after an attack. This presentation will outline DTRA's TNF R&D strategy and current investments, with efforts focusing on: (1) introducing new technical data collection capabilities (e.g., ground-based prompt diagnostics sensor systems; innovative debris collection and analysis); (2) developing new TNF process paradigms and concepts of operations to decrease timelines and uncertainties, and increase results confidence; (3) enhanced validation and verification (V&V) of capabilities through technology evaluations and demonstrations; and (4) updated weapon output predictions to account for the modern threat environment. A key challenge to expanding these efforts to a global capability is the need for increased post-detonation TNF international cooperation, collaboration and peer reviews.

  11. Defense AR Journal. Issue 56, Volume 17, Number 4. Measuring Programs and Progress

    Science.gov (United States)

    2010-10-01

    DEFENSE ACQUISITION REVIEW JOURNAL October 2010 Vol. 17 No. 4 | ISSUE 56 508 THE P-51 MUSTANG: A CASE STUDY IN DEFENSE ACQUISITION Alan Haggerty and Roy...time and money by exploring new test and analyses methods to assess aeromedical equipment for safety certification. The final article by Alan ...Fasanella, Tabiei, Brinkley , and Shemwell (2008) studied a crash test dummy model for NASA’s Orion crew module landings using FEA. Viisoreanu, Rutman, and

  12. Influences on the Timing and Frequency of Cancellations and Truncations of Major Defense Acquisition Programs

    Science.gov (United States)

    2017-03-01

    TPP) when it was judged to be practicable and, when not, a Fixed Price Incentive Fee (FPIF) or Cost Plus Incentive Fee (CPIF) contract. By 1966...left off, he ruled out the use of TPP and discouraged the use of FPIF for development contracts in favor of CPIF. ( Cost Plus Award Fee may not have...CPIF Cost Plus Incentive Fee CY Calendar Year DAB Defense Acquisition Board DAMIR Defense Acquisition Management Information Retrieval DCP

  13. Patriot/Medium Extended Air Defense System Combined Aggregate Program (Patriot/MEADS CAP)

    Science.gov (United States)

    2013-12-01

    FUE - First Unit Equipped IOT &E - Initial Operational Test and Evaluation Missile Milestones SAR Baseline Dev Est Current APB Development...Acquisition Management Information Retrieval Dev Est - Development Estimate DoD - Department of Defense DSN - Defense Switched Network Econ...Milestone c FUE IOT &E Start Complete Full Rate Production Deci... AcQuisition Increment 2 Milestone C Lightweight Launcher FUE IOT &E Start

  14. Program Manager: Journal of the Defense Systems Management College. Volume 19. Number 3

    Science.gov (United States)

    1990-06-01

    years. Fayol , Henri . General and Industrial Seatl, Washin"tn. He isa 1989groduate The current effort-the Defense Management. Toronto, Canada: Sir of...Institute, noted and Acquisition Costs," (Abellera); General Charles Henry , USA; and there are many congressional "Exchange Rates and Product Cost," Major...has been a Defense Systems Management College tions. Each Service has professional deterioration since 1986. The crucial were Mr. Henry Alberts, Dr

  15. Computer-supported indirect-form lifestyle-modification support program using Lifestyle Intervention Support Software for Diabetes Prevention (LISS-DP) for people with a family history of type 2 diabetes in a medical checkup setting: a randomized controlled trial.

    Science.gov (United States)

    Tokunaga-Nakawatase, Yuri; Nishigaki, Masakazu; Taru, Chiemi; Miyawaki, Ikuko; Nishida, Junko; Kosaka, Shiho; Sanada, Hiromi; Kazuma, Keiko

    2014-10-01

    To investigate the effect of a computer-supported indirect-form lifestyle-modification program using Lifestyle Intervention Support Software for Diabetes Prevention (LISS-DP), as a clinically feasible strategy for primary prevention, on diet and physical activity habits in adults with a family history of type 2 diabetes. This was a two-arm, randomized controlled trial: (1) lifestyle intervention (LI) group (n=70); (2) control (n=71). Healthy adults aged 30-60 years with a history of type 2 diabetes among their first-degree relatives were recruited. LI group received three times of lifestyle intervention using LISS-DP during six-month intervention period via mail. Lifestyle intervention group showed significantly greater decrease in energy intake six months after baseline, compared to control (-118.31 and -24.79 kcal/day, respectively, p=0.0099, Cohen's d=0.22), though the difference disappeared 1 year after from baseline. No difference was found in physical activity energy expenditure. A computer-based, non-face-to-face lifestyle intervention was effective on dietary habits, only during the intervention period. Further examination of the long-term effects of such intervention and physical activity is required. Copyright © 2014 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  16. Contributions of the Department of Defense Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs to Training and Education: FY1999-FY2004

    Science.gov (United States)

    2006-01-01

    allows visual tracking, free-floating Magnetic Levitation ( Maglev ) haptic feedback with real surgical tools and sce- nario-based training that can be...Defense Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs to Training and Education: FY1999–FY2004 J.D...Department of Defense Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs to Training and Education: FY1999

  17. Human thymic epithelial cells express functional HLA-DP molecules

    DEFF Research Database (Denmark)

    Jørgensen, A; Röpke, C; Nielsen, M

    1996-01-01

    T lymphocytes, we examined whether human thymic epithelial cells (TEC) expressed HLA-DP molecules. We present evidence that TEC obtained from short time culture express low but significant levels of HLA-DP molecules. The expression of HLA-DP molecules was comparable to or higher than the expression...... of HLA-DP allospecific primed lymphocyte typing (PLT) CD4 T cell lines. IFN-gamma treatment strongly upregulated the HLA-DP allospecific PLT responses whereas other PLT responses remained largely unchanged. In conclusion, these data indicate that human thymus epithelial cells express significant levels...

  18. Enzymatic Hydrolysis Conditions and Application of Pectinase DP100 and DP200 in Apple Juice%果胶酶DP100、DP200的酶解工艺条件及应用研究

    Institute of Scientific and Technical Information of China (English)

    田子卿; 马玉娟; 邓红; 韩瑞; 郭玉蓉

    2012-01-01

    探讨了advanceenzyme果胶酶DP100、DP200的酶解工艺,并在苹果汁中进行了应用试验,分析了酶解前后苹果汁各项指标的变化。通过正交试验得出果胶酶DP100、DP200的最佳酶解工艺条件分别为酶用量25mL/1000L、酶解时间30min、酶解温度50℃和酶用量35mL/1000L、酶解时间75min、酶解温度50℃;在最佳条件下,酶解处理果汁的透光率分别达到87.9%和93.7%。苹果汁的应用试验表明:经DP100及DP200酶解后的果汁均不合果胶,酶解后果汁透光率提高很大,且DP200处理效果优于DP100。所以,果胶酶DPl00及DP200均对苹果汁加工很有效,是实际可用品质好的酶产品。%The enzymatic hydrolysis conditions of the pectinase DP100 and DP200 were studied through LI6(45) orthogonal experiment. Under the optimum conditions, the two enzymes were applied in apple juice. The orthogonal experiment results showed that the optimum enzymatic hydrolysis conditions of pectinase DP100 and DP200 were amount of DP100 25 mL/1 000 L, temperature 50 ℃, time 30 min and amount of DP200 35 mL/1 000 L, 50 ℃ for 75 min, respectively .The transmittance of the apple juice after enzymolysis could get to 87.9% and 93.7%, respectively. The results of application in apple juice indicated that the juice treated with the two pectinases at the optimum conditions separately both had no pectin and the transmittance was improved greatly, DP200 was better than DP100. Therefore, pectinase DP100 and DP200 were very effective for apple juice processing, it could be used in practical production of apple iuice.

  19. Program Management at the National Nuclear Security Administration Office of Defense Nuclear Security: A Review of Program Management Documents and Underlying Processes

    Energy Technology Data Exchange (ETDEWEB)

    Madden, Michael S.

    2010-05-01

    The scope of this paper is to review the National Nuclear Security Administration Office of Defense Nuclear Security (DNS) program management documents and to examine the underlying processes. The purpose is to identify recommendations for improvement and to influence the rewrite of the DNS Program Management Plan (PMP) and the documentation supporting it. As a part of this process, over 40 documents required by DNS or its stakeholders were reviewed. In addition, approximately 12 other documents produced outside of DNS and its stakeholders were reviewed in an effort to identify best practices. The complete list of documents reviewed is provided as an attachment to this paper.

  20. Defense Data Network/TOPS-20 Tutorial. An Interative Computer Program.

    Science.gov (United States)

    1985-12-01

    GRUP SB-GOUP Defense Data Network, DDN, TOPS-20, computer FIEL GRUP SB-GOUP networking. 19 ABSTRACT (Continue on roverse if necessary and identify by...switching network dedicated to meeting the data communica- tion requirements of the DoD. The network is subdivided into " two functional areas: (1) the

  1. Joint Program Executive Office for Chemical and Biological Defense Collaboration Study

    Science.gov (United States)

    2011-03-01

    87 14. SUBJECT TERMS Technology Transition, Collaboration, Organizational Design Components, Chemical Biological Defense 16. PRICE CODE 17...Biological Medical Systems (JPM CBMS) JPM CBMS centrally manages and employs government and commercial pharmaceutical development best practices to oversee...none have been previously done on technology transfer and collaboration. Professor Sazali Wahab et al. of Universiti Putra Malaysia examined the

  2. Program Manager: Journal of the Defense Management College. Volume 16, Number 5, September-October 1987,

    Science.gov (United States)

    1987-10-01

    Defense Systems Knowledge of civilian and military engineering or Management .- , current DOD segments of DOD engineering College production/ improve... markt ur h’elin isthat pric gstrategy i -a fit a rc "-js Iten pt,turt he h firm can take m, le tnliuenCTd hv financial con ’tagc. Since executives

  3. Joint Program Executive Office for Chemical and Biological Defense Strategic Plan FY13-18

    Science.gov (United States)

    2012-06-01

    strategy calls for a global Biosurveillance network for timely disease surveillance of biological pathogens whether intentionally made or naturally... Biosurveillance . The President and Secretary of Defense provided renewed emphasis on rapidly and efficiently developing and manufacturing effective medical... Biosurveillance . Our ability to obtain early warning about the deliberate use or natural emergence of dangerous pathogens hinges upon the

  4. 76 FR 38048 - Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military...

    Science.gov (United States)

    2011-06-29

    .... E-mail: dfars@osd.mil . Include DFARS Case 2011-D034 in the subject line of the message. Fax: 703... preceding the solicitation of sources by DoD for the procurement or transaction, any of the following for Do... least the one- year period preceding the solicitation of sources by the Department of Defense for...

  5. Program Manager: Journal of the Defense Management College, Volume 23 Number 4, July-August 1994

    Science.gov (United States)

    1994-08-01

    Caruth Typography and Design Paula Croisetiere P’rograim Ma1nager (ISSN OtQY-7t 14) is Published bimonthly by the Defense Systems EQ 0 Management College...provides a standard black-and-white cover without illustrations showing the title, author, TR number and DSMC logo and similar title page. -The TRs

  6. Defense Transuranic Waste Program. Transuranic waste transportation assessment and guidance report

    Energy Technology Data Exchange (ETDEWEB)

    1985-08-01

    The Transportation Assessment and Guidance Report (TAGR) is designed to provide DOE-managed defense sites with guidance and citable analyses addressing National Environmental Policy Act (NEPA) requirements for qualifying and transporting transuranic (TRU) wastes to the Waste Isolation Pilot Plant (WIPP) in southeastern New Mexico.

  7. Navy Aegis Ballistic Missile Defense (BMD) Program: Background and Issues for Congress

    Science.gov (United States)

    2016-10-25

    developments in Australia, Japan , and South Korea. 93 Justin Doubleday, “MDA Looking to Integrate European Allies into Missile Defense Architecture ...12 Japan ................................................................................................................................. 12 Other...building, or are planning to build Aegis-equipped ships include Japan , South Korea, Australia, Spain, and Norway.2 Aegis BMD System3 Aegis ships

  8. Gulf team delivers on DP drillship promise

    Energy Technology Data Exchange (ETDEWEB)

    Flatern, R. von

    2001-06-01

    The technological achievements of the project by Amoco and BP to complete a deepwater subsea well in the Gulf of Mexico from a dynamically positioned (DP) vessel are described. In 2000, the dual activity drillship, Discoverer Enterprise (owned by Transocean Sedco Forex), completed the Nile well in the Viosca Knoll area and then the King Well in Mississippi Canyon Block 85. Stringent safety and environmental protection criteria imposed by Amoco and BP drove the design of the Dril-Quip subsea wellhead to ensure that the wellhead profile and connector coped with the worst case scenario. BP also specified a disconnect system that would secure the well in less than a minute. The SenTREE 7 and Commander telemetry systems developed by Schlumberger, the components of the work string and test work with the Nile well to ensure BP conditions were met and that the perforation and surge procedure proceeded successfully are explained. The time reduction achieved by using large DP drillships and future BP plans are outlined.

  9. Standing Up a Narcotic Confirmation Laboratory for the Russian Federation Ministry of Defense Nuclear Personnel Reliability Program

    Energy Technology Data Exchange (ETDEWEB)

    LukyanenkoMD, Victor [Russian Federation Ministry of Defense; Eisele, Gerhard R [ORNL; Coates, Cameron W [ORNL

    2010-01-01

    Through a cooperative effort between the U. S. Department of Energy and the Russian Federation (RF) Ministry of Defense (MOD) a Personnel Reliability Program (PRP) for the nuclear handlers within the RF MOD has been implemented. A key element in the RF MOD PRP is the detection and confirmation of narcotic use in subject military and civilian personnel. This paper describes the process of narcotics screening and testing in the RF MOD and explains the confirmation process once screening has shown a positive result. Issues of laboratory certification, employee certification, employee training, sample chain-of-custody, and equipment needs will be addressed.

  10. Navy Aegis Ballistic Missile Defense (BMD) Program: Background and Issues for Congress

    Science.gov (United States)

    2011-04-19

    many ships will be available; and how the alphabet- soup of U.S. and international commanders will work together in a crisis. [Admiral Mark...meeting outside of missile defense,” Campbell said during a Nov. 3 interview with Aviation Week. These include providing weapons and manpower for...would seem a natural mission for the Army to fund and field the land-based SM-3 mission as the lead service. Campbell notes that the Army has 10

  11. Evolution of the Department of Defense Millimeter and Microwave Monolithic Integrated Circuit Program

    Science.gov (United States)

    2007-02-01

    Dertouzos, Michael; Lester, Richard K.; Solow , Robert M.; Thorow, Lester C., “Toward a New Industrial America Scientific American, June 1989, pp...Vladimir Gelnovatch, Director of the U.S. Army Electronics Technology and Devices Laboratory; and Robert Heaston, Office of Under Secretary of Defense...Jack S. Kilby and Robert N. Noyce shared honors for the achievement. Hybrid microwave and millimeter wave integrated circuits achieved greater

  12. FP与DP方案同步放化疗治疗中晚期宫颈癌的临床疗效比较%Curative Effect of Program FP and DP in Synchronization with Radiotherapy on Medium-and Advanced Stage Cervical Cancer

    Institute of Scientific and Technical Information of China (English)

    贺艺; 徐岚; 何成; 黄丽琼

    2011-01-01

    目的 探讨顺铂+氟尿嘧啶(FP方案)和顺铂+多西紫杉醇(DP方案)同步放射治疗和化学治疗(放、化疗)中晚期宫颈癌的临床疗效和毒性反应.方法 125例经病理学或细胞学确诊的Ⅱb~Ⅳa期宫颈癌患者,随机分为FP组65例及DP组60例.FP组:顺铂40 mg·(m2)-1第1~4天静脉滴注,氟尿嘧啶1.0 mg·(m2)-1第1~5天静脉滴注,28 d为1 个周期,共用2个周期.DP组:多西紫杉醇135 mg·(m2)-1,第1天静脉滴注;顺铂40 mg·(m2)-1,第1~4天静脉滴注,28 d为1个周期,共用2个周期.对两组的临床疗效和不良反应进行对比观察.结果 FP组近期有效率为78.5%,DP组为91.7%,两组差异有统计学意义(P<0.05).FP组和DP组中位生存时间分别为32.4和31.7个月,2 a生存率分别为84.6%和86.7%,差异无统计学意义(P>0.05).两组不良反应相似,均以骨髓抑制、胃肠道反应为主,发生率及程度差异无统计学意义(P>0.05),可耐受.结论 FP方案和DP方案治疗中晚期宫颈癌均具有较好的耐受性和疗效,不良反应可以耐受.DP方案近期效果较FP方案更好,缓解率更高,可作为中晚期宫颈癌较理想的化疗方法之一.%Objective To study the clinic effect and toxic action of program FP ( cisplatin and fiuorouracil ) and DP ( cisplatin and docetaxel ) in synchronization with radiotherapy.Methods One hundred and twenty-five women diognosed as Ⅱ b ~ Ⅳ a stage cervix cancer by pathology and cytology were studied,whom were divided randomly into two groups, the FP group with 65 patients and DP group with 60 patients.The FP group were treated with cisplatin 40 mg· ( m2 ) -1 via vein from the first to fourth day, and with 5-fiurouracil 1.0 mg· ( m2 ) -1 via vein from the first to fifth day,28 days as a course of treatment, for totally two courses.The DP group were treated with docetaxel 135 mg· ( m2 ) -1 via vein in the first day,and cisplatin 135 mg· ( m2 )-1 from day one to four, 28 days as a course and two

  13. Cross-sectional survey on defensive practices and defensive behaviours among Israeli psychiatrists.

    Science.gov (United States)

    Reuveni, I; Pelov, I; Reuveni, H; Bonne, O; Canetti, L

    2017-03-20

    Psychiatry is a low-risk specialisation; however, there is a steady increase in malpractice claims against psychiatrists. Defensive psychiatry (DP) refers to any action undertaken by a psychiatrist to avoid malpractice liability that is not for the sole benefit of the patient's mental health and well-being. The objectives of this study were to assess the scope of DP practised by psychiatrists and to understand whether awareness of DP correlated with defensive behaviours. A questionnaire was administered to 213 Israeli psychiatry residents and certified psychiatrists during May and June 2015 regarding demographic data and experience with malpractice claims, medicolegal literature and litigation. Four clinical scenarios represented defensive behaviours and reactions (feelings and actions) to malpractice claims. Forty-four (20.6%) certified psychiatrists and four (1.9%) residents were directly involved in malpractice claims, while 132 (62.1%) participants admitted to practising DP. Residents acknowledged the practice of DP more than did senior psychiatrists (p=0.038).Awareness of DP correlated with unnecessary hospitalisation of suicidal patients, increased unnecessary follow-up visits and prescribing smaller drug dosages than required for pregnant women and elderly patients. This study provides evidence that DP is well established in the routine clinical daily practice of psychiatrists. Further studies are needed to reveal whether DP effectively protects psychiatrists from malpractice suits or, rather, if it impedes providing quality psychiatric care and represents an economic burden that leads to more harm for the patient. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  14. 77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Test Program for Negotiation...

    Science.gov (United States)

    2012-02-24

    ... Regulation Supplement; Extension of the Test Program for Negotiation of Comprehensive Small Business... Acquisition Regulation Supplement to extend the program period for the DoD Test Program for Negotiation of...). Section 866 amends the DoD Test Program for Negotiation of Comprehensive Small Business...

  15. Understanding Complexity and Self-Organization in a Defense Program Management Organization (Experimental Design)

    Science.gov (United States)

    2016-03-18

    start of the program. Earned value management data will be used to determine program schedule variance. Program Performance Program performance will...and schedule of the program. Table 4 provides a definition of key earned value terms. Table 4. Earned Value Management Key Terms Subsequent...Sasieni, M. W. (1968). The engineering and management of an effective system. Management Science, 14(12), B-721–B-730. Fredrickson, J. W

  16. HLA-DP antigens in patients with alopecia areata

    DEFF Research Database (Denmark)

    Ødum, Niels; Morling, N; Georgsen, J

    1990-01-01

    The distribution of HLA-DP antigens were studied in 41 patients with alopecia areata (AA) and 188 ethnically matched controls. An increase of DR4 and possibly DR5 in 24 of these patients has previously been reported. HLA-DP typing for DPw1 through w6 and the local specificity, CDP HEI, was perfor......The distribution of HLA-DP antigens were studied in 41 patients with alopecia areata (AA) and 188 ethnically matched controls. An increase of DR4 and possibly DR5 in 24 of these patients has previously been reported. HLA-DP typing for DPw1 through w6 and the local specificity, CDP HEI...

  17. Dystrophin Dp71 Isoforms Are Differentially Expressed in the Mouse Brain and Retina: Report of New Alternative Splicing and a Novel Nomenclature for Dp71 Isoforms.

    Science.gov (United States)

    Aragón, Jorge; González-Reyes, Mayram; Romo-Yáñez, José; Vacca, Ophélie; Aguilar-González, Guadalupe; Rendón, Alvaro; Vaillend, Cyrille; Montañez, Cecilia

    2017-01-27

    Multiple dystrophin Dp71 isoforms have been identified in rats, mice, and humans and in several cell line models. These Dp71 isoforms are produced by the alternative splicing of exons 71 to 74 and 78 and intron 77. Three main groups of Dp71 proteins are defined based on their C-terminal specificities: Dp71d, Dp71f, and Dp71e. Dp71 is highly expressed in the brain and retina; however, the specific isoforms present in these tissues have not been determined to date. In this work, we explored the expression of Dp71 isoforms in the mouse brain and retina using RT-PCR assays followed by the cloning of PCR products into the pGEM-T Easy vector, which was used to transform DH5α cells. Dp71-positive colonies were later analyzed by PCR multiplex and DNA sequencing to determine the alternative splicing. We thus demonstrated the expression of Dp71 transcripts corresponding to Dp71, Dp71a, Dp71c, Dp71b, Dp71ab, Dp71 Δ110, and novel Dp71 isoforms spliced in exon 74; 71 and 74; 71, 73 and 74; and 74 and 78, which we named Dp71d Δ74 , Dp71d Δ71,74 , Dp71d Δ71,73-74 , and Dp71f Δ74 , respectively. Additionally, we demonstrated that the Dp71d group of isoforms is highly expressed in the brain, while the Dp71f group predominates in the retina, at both the cDNA and protein levels. These findings suggest that distinct Dp71 isoforms may play different roles in the brain and retina.

  18. Post Milestone B Funding Climate and Cost Growth in Major Defense Acquisition Programs

    Science.gov (United States)

    2017-03-01

    assumptions are made in the hope that, by making the program appear to be lower in cost or more capable, they will increase the odds that the program will...hope that, by making the program appear to be lower in cost or more capable, they will increase the odds that the program will be successful in...Package Procurement (TPP).13 Acquisition reforms adopted in mid-1969 ruled out use of TPP and fixed- price development contracts because they typically

  19. Predictive value of self-reported and observer-rated defense style in depression treatment.

    NARCIS (Netherlands)

    Van, H.L.; Dekker, J.J.M.; Peen, J.; Abraham, R.E.; Schoevers, R.

    2009-01-01

    This study explored the predictive value of observer-rated and self-reported defensive functioning on the outcome of psychotherapy for the treatment of depression. Defense styles were measured according to the Developmental Profile (DP) and the Defense Style Questionnaire (DSQ) in 81 moderately seve

  20. 75 FR 66686 - Defense Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption for...

    Science.gov (United States)

    2010-10-29

    ... Regulation Supplement; Balance of Payments Program Exemption for Commercial Information Technology... Acquisition Regulation Supplement (DFARS) to implement the exemption from the Balance of Payments Program for... is amending the DFARS to implement in the clauses at 252.225- 7044, Balance of Payments...

  1. Defense Institution Building: An Assessment

    Science.gov (United States)

    2016-01-01

    MoDA and DIILS Support of DIB Activity Objectives . . . . . . . 26 2.8. Overlapping Program Objectives...Wales Initiative Fund–Defense Institution Building (WIF-DIB), the Ministry of Defense Advisors ( MoDA ) program, and the Defense Insti- tute of...other events and activities related to a partner nation’s defense institution capabilities and capacity. One exception is MoDA , where engagements are

  2. Overcoming Resistance to Change: An Analysis to the Department of Defense's Anthrax Vaccine Immunization Program

    National Research Council Canada - National Science Library

    Johnson, Irene

    2004-01-01

    The goal of this research was to investigate the impact of change on organizations, in the absence of a preparedness program and to develop strategies for overcoming resistance to change, in the midst...

  3. Major Automated Information Systems: Selected Defense Programs Need to Implement Key Acquisition Practices

    Science.gov (United States)

    2014-03-01

    information system NGEN Next Generation Enterprise Network PMBOK ® Project Management Body of Knowledge TMIP-J Theater Medical Information Program...Management Institute’s Guide to the Project Management Body of Knowledge ( PMBOK ®), and assessed each of the 3 programs against these criteria.14 To...1) requirements management and (2) project monitoring and control best practices, as defined by CMMI-ACQ and PMBOK ®. We also assessed these

  4. Defense Small Business Innovation Research Program (SBIR). Volume 2. Navy Abstracts of Phase 1 Awards. 1990

    Science.gov (United States)

    1990-01-01

    TRAINING. DELFIN SYSTEMS 1349 MOFFETT PARK DR 78 SMALL BUSINESS INNOVATION RESEARCH PROGRAM - PHASE I NAVY Solicitation 90.1 SUNNYVALE, CA 94089 Program...MACHINE-INTERFACES (MMI). IMPLEMENTED MMI DESIGN SHOULD REFLECT HOW THE OPERATOR ACTUALLY USES AND INTERACTS WITH THE MACHINE. DELFIN WILL ANALYZE AND...DESIGN A GENERIC EXPERT SYSTEM MMI USEFUL IN ANY DEPLOYED ESM SYSTEM. DELFIN WILL GENERICALLY DEFINE CRYPTOLOGIC SYSTEMM USE AND TECHNICAL

  5. Addressing the Barriers to Agile Development in the Department of Defense: Program Structure, Requirements, and Contracting

    Science.gov (United States)

    2015-04-30

    barriers within the DoD acquisition system (Broadus, 2013). MITRE performed initial research to examine the leading Agile methodologies and commercial...that suit each organization’s IT environment. Various Agile methods (e.g., Scrum , Extreme Programming (XP), Kanban, Test Driven Development) have... methodology . Traditional waterfall programs usually have discrete acquisition phases driven by milestone events to deliver a large capability. Agile is more

  6. Department of Defense (DOD) renewables and energy efficiency planning (REEP) program manual

    Energy Technology Data Exchange (ETDEWEB)

    Nemeth, R.J.; Fournier, D.; Debaillie, L.; Edgar, L.; Stroot, P.; Beasley, R.; Edgar, D.; McMillen, L.; Marren, M.

    1995-08-01

    The Renewables and Energy Efficiency Planning (REEP) program was developed at the US Army Construction Engineering Research Laboratories (USACERL). This program allows for the analysis of 78 energy and water conservation opportunities at 239 major DOD installations. REEP uses a series of algorithms in conjunction with installation specific data to estimate the energy and water conservation potential for entire installations. The program provides the energy, financial, pollution, and social benefits of conservation initiatives. The open architecture of the program allows for simple modification of energy and water conservation variables, and installation database values to allow for individualized analysis. The program is essentially a high-level screening tool that can be used to help identify and focus preliminary conservation studies. The REEP program requires an IBM PC or compatible with a 80386 or 80486 microprocessor. It also requires approximately 4 megabytes of disk space and at least 8 megabytes of RAM. The system was developed for a Windows environment and requires Microsoft Windows 3.1{trademark} or higher to run properly.

  7. Acquisition Program Teamwork and Performance Seen Anew: Exposing the Interplay of Architecture and Behaviors in Complex Defense Programs

    Science.gov (United States)

    2016-04-30

    implemented in a performance measurement system.  It must have a clear sampling approach, frequency, unit of analysis, etc. in order to produce reliable...straightjacket on learning, depending upon the judgement of program and team leaders to make strategic adjustments. Perhaps an approach that relies on the basic...validate this approach from multiple programs will be a lengthy process, but sample identification is already underway. Early experiments using the

  8. Defense Small Business Innovation Research Program (SBIR). Volume 4. Defense Agency Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

    Science.gov (United States)

    1990-04-01

    LABORATORY UNDER THE CODE NAME " DELPHI ", FOR THE OFFICE OF STRATEGIC DEFENSE; AND BETATRON RESEARCH CONDUCTED BY BOTH U.S. AND SOVIET SOURCES SUPPORTS THE...TITLE: HYPERGOLIC FUEL INJECTOR FEATURES INCREASED UTILITY FOR REMOTELY PILOTED VEHICLES (RPVs) INCREASED RANGE ENDURANCE PAYLOAD MULTI.. TOPIC# 20...OFFICE: PM/SBIR IDENT#: 33860 A HYPERGOLIC FUEL INJECTOR IS DESCRIBED THAT ENABLES MULTIFUEL OPERATION, LOWER FUEL CONSUMPTION, AND ENHANCED ALL WEATHER

  9. Commercializing Defense Technologies and Helping Defense Firms Succeed in Commercial Markets: A Report on the Objectives, Activities, and Accomplishments of the TAP-IN Program

    Science.gov (United States)

    1997-01-01

    Technology Access for Product Innovation (TAP-IN), the largest technology deployment project funded by TRP, was competitively selected through a national solicitation for proposals. TAP-IN was created to help companies access and apply defense technologies and help defense-dependent companies enter new commercial markets. Defense technologies included technologies developed by DoD, DOE, NASA, and their contractors. TAP-IN was structured to provide region-based technology access services that were able to draw on technology resources nationwide. TAP-IN provided expert assistance in all stages of the commercialization process from concept through prototype design to capital sourcing and marketing strategy. TAP-IN helped companies locate new technology, identify business partners, secure financing, develop ideas for new products, identify new markets, license technology, solve technical problems, and develop company-specific applications of federal technology. TAP-IN leveraged NASA's existing commercial technology network to create an integrated national network of organizations that assisted companies in every state. In addition to NASA's six regional technology transfer centers (RTTCs), TAP-IN included business and technology development organizations in every state, the Industrial Designers Society of America, and the Federal Laboratory Consortium (FLC).

  10. Department of Defense HIV/AIDS Prevention Program (DHAPP): 2006 Annual Report

    Science.gov (United States)

    2007-01-01

    The Comité Central de Prevención y Control del VIH/ SIDA de las Fuerzas Armadas y Po- licía Nacional del Perú (COPRECOS) is a gov- B A C K G R O U N D...The goal of the fiscal year 2005 program was to deter- mine the prevalence of HIV infection and other STIs (hepatitis B virus [HBV], hepatitis C... virus [HCV], syphilis, and human T-cell lymphotrophic virus type 1 [HTLV-1]) in Peruvian military personnel. A program similar to that in the US

  11. Somatodendritic and excitatory postsynaptic distribution of neuron-type dystrophin isoform, Dp40, in hippocampal neurons

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, Takahiro; Itoh, Kyoko, E-mail: kxi14@koto.kpu-m.ac.jp; Yaoi, Takeshi; Fushiki, Shinji

    2014-09-12

    Highlights: • Identification of dystrophin (Dp) shortest isoform, Dp40, is a neuron-type Dp. • Dp40 expression is temporally and differentially regulated in comparison to Dp71. • Somatodendritic and nuclear localization of Dp40. • Dp40 is localized to excitatory postsynapses. • Dp40 might play roles in dendritic and synaptic functions. - Abstract: The Duchenne muscular dystrophy (DMD) gene produces multiple dystrophin (Dp) products due to the presence of several promoters. We previously reported the existence of a novel short isoform of Dp, Dp40, in adult mouse brain. However, the exact biochemical expression profile and cytological distribution of the Dp40 protein remain unknown. In this study, we generated a polyclonal antibody against the NH{sub 2}-terminal region of the Dp40 and identified the expression profile of Dp40 in the mouse brain. Through an analysis using embryonic and postnatal mouse cerebrums, we found that Dp40 emerged from the early neonatal stages until adulthood, whereas Dp71, an another Dp short isoform, was highly detected in both prenatal and postnatal cerebrums. Intriguingly, relative expressions of Dp40 and Dp71 were prominent in cultured dissociated neurons and non-neuronal cells derived from mouse hippocampus, respectively. Furthermore, the immunocytological distribution of Dp40 was analyzed in dissociated cultured neurons, revealing that Dp40 is detected in the soma and its dendrites, but not in the axon. It is worthy to note that Dp40 is localized along the subplasmalemmal region of the dendritic shafts, as well as at excitatory postsynaptic sites. Thus, Dp40 was identified as a neuron-type Dp possibly involving dendritic and synaptic functions.

  12. Defense Small Business Innovation Research Program (SBIR) Abstracts of Phase I Awards 1984.

    Science.gov (United States)

    1985-04-16

    INTEGRATED BUILDING ENERGY EVALUATION PROGRAM, TO BE APPLIED TO LARGE BUILDINGS THAT DETERMINES THE OVERALL BUILDING ENERGY EFFICIENCY AND DIAGNOSES SPECIFIC...STANDARDS TO PROVIDE BUILDING ENERGY EFFICIENCY EVALUATION. MORE IMPORTANTLY, IT WILL INDICATE AREAS OF INEFFICIENCY TO BE IMPROVED. MANY DATA INPUTS TO

  13. The Myth of Jointness in Department of Defense Requirements and Major Acquisition Programs

    Science.gov (United States)

    2013-06-01

    and Program Management for the F-4 Phantom II," Social Studies of Science 23, no. 2 (May 1993): 287. 5 Deborah Shapley, Promise and Power: The...for the F-4 Phantom II.” Social Studies of Science 23, No. 2 (May, 1993): 265-300. Bull, Stephen. "Encyclopedia of Military Technology and

  14. Defense Small Business Innovation Research Program (SBIR). Volume 3. Air Force Abstracts of Phase 1 Awards

    Science.gov (United States)

    1990-01-01

    ROBOTS. KINOPHASE 14 HOLLY HILL DR AMHERST, NH 03031 Program Manager: GENE C KOCH Contract #: Title: LIQUID CRYSTAL SWITCHABLE KINOFORM LENSES FOR...NETWORKS WILL BE USED TO DEVELOP A REAL- CIME , MULTIMODALITY, NONINTRUSIVE PHYSIOLOGICAL METRIC OF MENTAL WORKLOAD. OUR METRIC WILL MEASURE MENTAL

  15. RDT&E Programs (R-1). Department of Defense Budget Fiscal Year 2010

    Science.gov (United States)

    2009-05-01

    52,716 U ( SIAP ) System Engineer (SE) 73 0603889N Counterdrug RDT&E Projects 04...20,582 U 91 0605452F Joint SIAP Executive Program 05 34,877...4,723 66,663 13,466 13,466 U ( SIAP ) 95 0207701F Full Combat Mission

  16. Defense Small Business Innovation Research Program (SBIR) Volume 2. Navy Abstracts of Phase 1 Awards, 1987

    Science.gov (United States)

    1988-04-01

    DYNAMICS, INCLUDING AUTOPILOT , AND AN ADEQUATE SIMULATED TERRAIN IMAGE FOR VEHICLES WITH ON-BOARD SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM...ELECTRONICS DOES NOT EXCEED A FRACTION OF A VOLT, NOT LIKELY IF THE RATE OF CHANGE OF AXIAL FLUX DENSITY IS LESS THAN 2.5 TESLA /SEC. A UNIQUE

  17. Microstructure and mechanical properties of laser welded dissimilar DP600/DP980 dual-phase steel joints

    Energy Technology Data Exchange (ETDEWEB)

    Farabi, N. [Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3 (Canada); Chen, D.L., E-mail: dchen@ryerson.ca [Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3 (Canada); Zhou, Y. [Department of Mechanical and Mechatronics Engineering, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1 (Canada)

    2011-01-21

    Research highlights: > Laser welding results in a significant hardness rise in the fusion zone, but the formation of a soft zone in the heat-affected zone. > A characteristic unsymmetrical hardness profile is observed across the dissimilar joint. > Yield point phenomenon with only stage III strain hardening occurs after welding. > Fatigue life at higher stress amplitudes is equivalent to that of DP600 steel despite slightly lower fatigue limit. - Abstract: The use of dual phase (DP) steels in the automobile industry unavoidably involves welding and dynamic loading. The aim of this investigation was to evaluate the microstructural change and mechanical properties of laser welded dissimilar DP600/DP980 steel joints. The dissimilar joints showed a significant microstructural change from nearly full martensite in the fusion zone (FZ) to the unchanged ferrite-martensite dual-phase microstructure in the base metal. The welding resulted in a significant hardness increase in the FZ but the formation of a soft zone in the heat-affected zone (HAZ). The dissimilar welded joints were observed to exhibit a distinctive unsymmetrical hardness profile, yield-point-like phenomenon, and single-stage work hardening characteristic, with yield strength and work hardening rate lying in-between those of DP600 and DP980 base metals, and ultimate tensile strength equivalent to that of DP600 base metal. Although the welded joints showed a lower fatigue limit than the base metals, the fatigue life of the welded joints at higher stress amplitudes was almost the same as that of the DP600 base metal. The welded joints failed in the soft zone at the DP600 side under tensile loading and fatigue loading at the higher stress amplitudes. Fatigue crack initiation occurred from the specimen surface and crack propagation was characterized by typical fatigue striation together with secondary cracks.

  18. The HLA-DP polymorphism in Denmark investigated by local and international PLT reagents. Definition of two "new" DP antigens

    DEFF Research Database (Denmark)

    Ødum, Niels; Hartzman, R; Jakobsen, B K

    1986-01-01

    Lymphocytes from highly selected donors were primed for 10 days and subsequently bulk-expanded in IL 2 (TCGF) containing cultures. Two well-discriminatory PLT (CDP = Copenhagen DP) reagents against each of the DPw1-w6 specificities and one against each of the two "new" specificities, CDP4s and CD....... The associations between DR3-DPw1, DR2-DPw4, and DRw6-DPw2 were confirmed. It is concluded that DP-typing with bulk-expanded reagents is a reliable and so far the only technique which can reveal the polymorphism of the DP gene products....

  19. Left-right entanglement entropy of Dp-branes

    Energy Technology Data Exchange (ETDEWEB)

    Zayas, Leopoldo A. Pando [The Abdus Salam International Centre for Theoretical Physics,Strada Costiera 11, 34014 Trieste (Italy); Michigan Center for Theoretical Physics, Randall Laboratory of Physics,The University of Michigan,450 Church Street, Ann Arbor, MI 48109-1120 (United States); Quiroz, Norma [Departamento de Ciencias Exactas, Tecnología y Metodología,Centro Universitario del Sur, Universidad de Guadalajara,Enrique Arreola Silva 883, C.P. 49000, Cd. Guzmán, Jalisco (Mexico)

    2016-11-04

    We compute the left-right entanglement entropy for Dp-branes in string theory. We employ the CFT approach to string theory Dp-branes, in particular, its presentation as coherent states of the closed string sector. The entanglement entropy is computed as the von Neumann entropy for a density matrix resulting from integration over the left-moving degrees of freedom. We discuss various crucial ambiguities related to sums over spin structures and argue that different choices capture different physics; however, we advance a themodynamic argument that seems to favor a particular choice of replica. We also consider Dp branes on compact dimensions and verify that the effects of T-duality act covariantly on the Dp brane entanglement entropy. We find that generically the left-right entanglement entropy provides a suitable generalization of boundary entropy and of the D-brane tension.

  20. Left-Right Entanglement Entropy of Dp-branes

    CERN Document Server

    Zayas, Leopoldo A Pando

    2016-01-01

    We compute the left-right entanglement entropy for Dp-branes in string theory. We employ the CFT approach to string theory Dp-branes, in particular, its presentation as coherent states of the closed string sector. The entanglement entropy is computed as the von Neumann entropy for a density matrix resulting from integration over the left-moving degrees of freedom. We discuss various crucial ambiguities related to sums over spin structures and argue that different choices capture different physics. We also consider Dp branes on compact dimensions and verify that the effects of T-duality act covariantly on the Dp brane entanglement entropy. We find that generically the left-right entanglement entropy provides a suitable generalization of boundary entropy and of the D-brane tension.

  1. Waste minimization policies, regulations, and practices within the U.S. Department of Energy defense programs

    Energy Technology Data Exchange (ETDEWEB)

    Mathur, S.P.

    1989-11-01

    In 1984 the US Congress enacted the Hazardous and Solid Waste Amendments (HSWA) to the Resource Conservation and Recovery Act (RCRA). One of the goals of this legislation was to focus attention on the need to reduce or eliminate hazardous waste so as to minimize the threat to human health and the environment. Subsequently, in September of 1988, DOE issued a Radioactive Waste Management Policy, DOE Order 5820.2A, and in November a General Environmental Program Order, DOE Order 5400.1. These documents embrace the principles set forth in RCRA, and expand their scope to include radioactive, mixed, and pollutant waste, and all actions for reducing waste from the point of generation through waste treatment, storage, transportation and disposal. This paper will present an overview of the legislation and policies for waste reduction and, in addition, give site responsibilities for implementing waste reduction program activities.

  2. Waste minimization policies, regulations, and practices within the U.S. Department of Energy defense programs

    Energy Technology Data Exchange (ETDEWEB)

    Mathur, S.P.

    1989-11-01

    In 1984 the US Congress enacted the Hazardous and Solid Waste Amendments (HSWA) to the Resource Conservation and Recovery Act (RCRA). One of the goals of this legislation was to focus attention on the need to reduce or eliminate hazardous waste so as to minimize the threat to human health and the environment. Subsequently, in September of 1988, DOE issued a Radioactive Waste Management Policy, DOE Order 5820.2A, and in November a General Environmental Program Order, DOE Order 5400.1. These documents embrace the principles set forth in RCRA, and expand their scope to include radioactive, mixed, and pollutant waste, and all actions for reducing waste from the point of generation through waste treatment, storage, transportation and disposal. This paper will present an overview of the legislation and policies for waste reduction and, in addition, give site responsibilities for implementing waste reduction program activities.

  3. Development of an Intellectual Property Strategy: Research Notes to Support Department of Defense Programs

    Science.gov (United States)

    2014-10-01

    such as poetry , novels, movies, songs, computer software, drawings, and architecture. A copyright owner has the exclusive right to reproduce...market research—can support how requirements may be logically broken out into segments to maximize competition  records that substantiate sources...entitlement will maximize a program’s ability to utilize competitive alternatives for DoD development, modification, or upgrade effort. One suggestion is to

  4. Defense Small Business Innovation Research Program (SBIR). Volume 1. Army Abstracts of Phase 1 Awards 1987.

    Science.gov (United States)

    1988-04-01

    DIMENSIONAL FLOW SOLUTIONS. HORINE ENGINEERS INC PO BOX 2027 LOS GATOS , CA 95031 CONTRACT NUMBER: DAAA21-87-C-0190 CARLTON L HORINE TITLE: p IMPROVED GASKET...AN UNPARALLELED OPPORTUNITY TO SCREEN BACTERIA , FUNGI AND ALGAE FROM THERMALLY STABLE OXIDASES AND PEROXIDASES. ONCE ISOLATED, AN ATTEMPT WILL BE MADE...PROGRAM - PHASE 1 PAGE 106 BY SERVICE FISCAL YEAR 1987 ARMY SUBMITTED BY • TO DEVELOP AND TEST A SYSTEM. LASER-GENICS CORP PO BOX 33010 LOS GATOS , CA

  5. A Macro-Stochastic Approach to Improved Cost Estimation for Defense Acquisition Programs

    Science.gov (United States)

    2014-03-27

    the United States Government. This material is declared a work of the U.S. Government and is not subject to copyright protection in the United...Aircraft, Helicopter, Missile , Electronic, Munitions, Vehicle, Ship, Space, and Other. Other summary-level variables include service component...older DDG-51 ships (Cancian, 2010)—both of these programs are in the dataset. Also, the Army’s “Longbow” 84 helicopter, and the “Longbow Hellfire

  6. Sources of Weapon System Cost Growth. Analysis of 35 Major Defense Acquisition Programs

    Science.gov (United States)

    2008-01-01

    Resource Management Program of RAND Proj- iii ect AIR FORCE. The project’s technical monitor is Jay Jordan, Techni- cal Director of the Air Force Cost...and for his long-term support of Project AIR FORCE’s acquisi- tion and cost analysis research. Richard Hartley (SAF/FMC) and Jay Jordan from the Air...Wickman (1993), Tyson, Nelson, and Utech (1992), Shaw (1982), Tyson et al. (1989), Asher and Maggelet (1984), and Drezner et al. (1993) studied cost

  7. Defense Acquisitions. Measuring the Value of DOD’s Weapon Programs Requires Starting with Realistic Baselines

    Science.gov (United States)

    2009-04-01

    schedule delay in delivering initial capabilities 18 months 21 months 22 months Source: GAO analysis of DOD data. aData were obtained from DOD’s...efficient. Too many major acquisitions currently take the opposite approach by seeking to deliver a revolutionary “ big bang” capability in one step...candidate programs and to go for the “ big bang” capability without the knowledge to achieve it should be resisted. Only the best candidates--defined in

  8. Improving Oversight and Coordination of Department of Defense Programs That Address Problematic Behaviors Among Military Personnel

    Science.gov (United States)

    2017-01-01

    with an increasing representation of minorities, greater racial diversity in positions of authority, and a smaller racial wage gap .”91 Risk Factors...strategic convergence, as well as potential gaps along the prevention spectrum at which program and research efforts might be applied, with the...significant gap in DoD’s frame- work for mitigating problematic behavior. Although the Office of Diversity Management and Equal Opportunity is

  9. Defense Small Business Innovation Research Program (SBIR). Abstracts of Phase I Awards. 1986.

    Science.gov (United States)

    1986-01-01

    EMPHASIS OF ANY PHASE II WORK. ANAMET LABS INC AF $ 49,031 100 INDUSTRIAL WY SAN CARLOS, CA 94070 DANTON GUTIERREZ-LFMINI TITLE: COUPLED THERMOELASTIC...NATIONAL DR - STE 280 BURTONSVILLE, MD 20866 GEORGE MAHLER TITLE: THLL BASED SYMBOLIC DEBUG FACILITY FOR VAX/VMS T 104 OFFICE: NSWC THLL IS THE TRIDENT...VALLEY RD., SUITE 112 SAN DIEGO, CA 92121 GEORGE W WEBB , TITLE: MINIATURE CONDUCTORS FOR SENSORS T 3 OFFICE: WE DESCRIBE A FOUR PART RESEARCH PROGRAM

  10. Innovative Science and Technology, Ballistic Missile Defense Organization, Technical Program Information.

    Science.gov (United States)

    2007-11-02

    will be encouraged to follow-up with additional documentation - for example, a white paper or formal proposal. In addition to basic program efforts...related devices for opto-electronics, double heterostructures composed of AlGaN, GaN, and InGaN based layers for laser diode applications, as well...emitting diode ( LED ) structures. Opportunities Unique chemical approaches for ultra-fast EO external modulators; opto-electronic, ultra-high-speed signal

  11. Engineering the Business of Defense Acquisition: An Analysis of Program Office Processes

    Science.gov (United States)

    2015-04-30

    5000.02. While it is important to better understand the interactions and decision-making that occurs within a program office, the dependent nature... Amaral & Uzzi, 2007). Specialization has a limiting function, in that the specialists in a PMO are measured by, and capable of addressing only...varies depending on the nature of the internal formal and informal processes. Eisenhardt (1989) noted that more information, considered simultaneously

  12. Strategic Defense Initiative Demonstration/Validation Program Environmental Assessment. Exoatmospheric Reentry Vehicle Interception System (ERIS),

    Science.gov (United States)

    1987-08-01

    2; - 4; C i O Ga. ; . ft* .4 .4 ~I A la 4. a d .4 . - aa .3 r U. AM 0SP0 o~~0 0.ei. ’U4 Is .~ -4 -- I r ’M .0. ~ aDa id .40 *l - 3~.4 144 0.U .4z- z... Lovelace , Norm, Environmental Protection Agency, Permit Programs, Micronesia, Region IX, San Francisco, California. 27 May 1987. Tele- phone

  13. Department of Defense High Performance Computing Modernization Program. 2006 Annual Report

    Science.gov (United States)

    2007-03-01

    Ground, MD Tip-to-Tail Turbulent Scramjet Flowpath Simulation with MHD Energy Bypass Datta Gaitonde, Air Force Research Laboratory, Wright- Patterson...Stennis Space Center in Mississippi, through a Phase II CAP titled “Quantum and Entropic Algorithms for MHD and Turbulent Flows.” They tested new...14 Force Field Lectures 50 HPC FPGA Programming 10 Insight Segmentation and Registration Toolkit Workshop (ITK) 18 Intermediate-Advanced EnSight 10

  14. Joint Service Chemical and Biological Defense Program FY 08-09 Overview

    Science.gov (United States)

    2007-10-01

    detoxifying component. These include photocatalysts, nanoceramic -supported enzymes, and biocides/sporocides. Researchers will also pursue technologies...oil, and lubricants (POLs)—significant capability improvements for the armor community. The JSLIST Block II Glove Upgrade (JB2GU) provides protection...Strategy, and Support PM Project manager POL petroleum, oil, and lubricants POM Program objective memorandum PPE personal protective equipment R&D

  15. targetDP: an Abstraction of Lattice Based Parallelism with Portable Performance

    CERN Document Server

    Gray, Alan

    2014-01-01

    To achieve high performance on modern computers, it is vital to map algorithmic parallelism to that inherent in the hardware. From an application developer's perspective, it is also important that code can be maintained in a portable manner across a range of hardware. Here we present targetDP, a lightweight programming layer that allows the abstraction of data parallelism for applications that employ structured grids. A single source code may be used to target both thread level parallelism (TLP) and instruction level parallelism (ILP) on either SIMD multi-core CPUs or GPU-accelerated platforms. targetDP is implemented via standard C preprocessor macros and library functions, can be added to existing applications incrementally, and can be combined with higher-level paradigms such as MPI. We present CPU and GPU performance results for a benchmark taken from the lattice Boltzmann application that motivated this work. These demonstrate not only performance portability, but also the improved optimisation resulting...

  16. Time Domain Simulation of a One Line Failure for a DP-assisted Mooring System

    Institute of Scientific and Technical Information of China (English)

    Jianxun Zhu; Liping Sun; Shengnan Liu; Jichuang Kang

    2014-01-01

    This paper focuses on the research of a semi-submersible platform equipped with a DP-assisted mooring system. Based on the working principles of the DP-assisted mooring system and the model of the platform motion, a time domain simulation program is applied to analyze the impact, in the case of one line failure, on the platform motion, power consumption of the thrusters and the tension of the mooring lines. The results show that, under the 10-year wind dominant, a one line failure will have little impact on the tension of the mooring lines. When the failure line is windward, the power consumption will increase greatly with a weakened position of accuracy. However when the failure line is leeward, the power consumption will be reduced with a partly strengthened position of accuracy.

  17. Somatodendritic and excitatory postsynaptic distribution of neuron-type dystrophin isoform, Dp40, in hippocampal neurons.

    Science.gov (United States)

    Fujimoto, Takahiro; Itoh, Kyoko; Yaoi, Takeshi; Fushiki, Shinji

    2014-09-12

    The Duchenne muscular dystrophy (DMD) gene produces multiple dystrophin (Dp) products due to the presence of several promoters. We previously reported the existence of a novel short isoform of Dp, Dp40, in adult mouse brain. However, the exact biochemical expression profile and cytological distribution of the Dp40 protein remain unknown. In this study, we generated a polyclonal antibody against the NH2-terminal region of the Dp40 and identified the expression profile of Dp40 in the mouse brain. Through an analysis using embryonic and postnatal mouse cerebrums, we found that Dp40 emerged from the early neonatal stages until adulthood, whereas Dp71, an another Dp short isoform, was highly detected in both prenatal and postnatal cerebrums. Intriguingly, relative expressions of Dp40 and Dp71 were prominent in cultured dissociated neurons and non-neuronal cells derived from mouse hippocampus, respectively. Furthermore, the immunocytological distribution of Dp40 was analyzed in dissociated cultured neurons, revealing that Dp40 is detected in the soma and its dendrites, but not in the axon. It is worthy to note that Dp40 is localized along the subplasmalemmal region of the dendritic shafts, as well as at excitatory postsynaptic sites. Thus, Dp40 was identified as a neuron-type Dp possibly involving dendritic and synaptic functions.

  18. Extracellular Polyhydroxyalkanoate Depolymerase by Acidovorax sp. DP5

    Directory of Open Access Journals (Sweden)

    S. Vigneswari

    2015-01-01

    Full Text Available Bacteria capable of degrading polyhydroxyalkanoates (PHA by secreting extracellular depolymerase enzymes were isolated from water and soil samples collected from various environments in Malaysia. A total of 8 potential degraders exhibited clear zones on poly(3-hydroxybutyrate [P(3HB] based agar, indicating the presence of extracellular PHA depolymerase. Among the isolates, DP5 exhibited the largest clearing zone with a degradation index of 6.0. The highest degradation activity of P(3HB was also observed with depolymerase enzyme of DP5 in mineral salt medium containing P(3HB. Based on biochemical characterization and 16S rRNA cloning and sequencing, isolate DP5 was found to belong to the genus Acidovorax and subsequently named as Acidovorax sp. DP5. The highest extracellular depolymerase enzyme activity was achieved when 0.25% (w/v of P(3HB and 1 g/L of urea were used as carbon and nitrogen source, respectively, in the culture media. The most suitable assay condition of the depolymerase enzyme in response to pH and temperature was tested. The depolymerase produced by strain Acidovorax sp. DP5 showed high percentage of degradation with P(3HB films in an alkaline condition with pH 9 and at a temperature of 40°C.

  19. Review of the President’s Fiscal Year 2009 Budget Request for the Defense Health Program’s Private Sector Care Budget Activity Group

    Science.gov (United States)

    2008-05-28

    2009 budget request for the Defense Health Program’s Private Sector Care BAG. To do this, we reviewed (1) DOD’s justification for the request for the... Private Sector Care BAG, including the underlying estimates and the extent to which DOD considered historical information; and (2) changes between this...develop the budget requests for the Private Sector Care BAG in fiscal years 2008 and 2009. We also interviewed officials and analyzed documents from

  20. Air Force Major Defense Acquisition Program Cost Growth Is Driven by Three Space Programs and the F-35A: Fiscal Year 2013 President’s Budget Selected Acquisition Reports

    Science.gov (United States)

    2014-01-01

    production FSD full-scale development FY fiscal year FYDP Future Years Defense Program GBS Global Broadcast System GLCM Ground Launched Cruise...Surveillance Target Attack Radar System (JSTARS) aircraft • Air-Launched Cruise Missile (ALCM) • Ground-Launched Cruise Missile ( GLCM ) • AGM-65A/B

  1. Separable Potentials for (d,p) Reaction Calculations

    CERN Document Server

    Elster, Ch; Eremenko, V; Nunes, F M; Thompson, I J; Arbanas, G; Escher, J E

    2015-01-01

    An important ingredient for applications of nuclear physics to e.g. astrophysics or nuclear energy are the cross sections for reactions of neutrons with rare isotopes. Since direct measurements are often not possible, indirect methods like $(d,p)$ reactions must be used instead. Those $(d,p)$ reactions may be viewed as effective three-body reactions and described with Faddeev techniques. An additional challenge posed by $(d,p)$ reactions involving heavier nuclei is the treatment of the Coulomb force. To avoid numerical complications in dealing with the screening of the Coulomb force, recently a new approach using the Coulomb distorted basis in momentum space was suggested. In order to implement this suggestion, one needs to derive a separable representation of neutron- and proton-nucleus optical potentials and compute their matrix elements in this basis.

  2. Separable Optical Potentials for (d,p) Reactions

    CERN Document Server

    Elster, Ch; Eremenko, V; Nunes, F M; Arbanas, G; Escher, J E; Thompson, I J

    2014-01-01

    An important ingredient for applications of nuclear physics to e.g. astrophysics or nuclear energy are the cross sections for reactions of neutrons with rare isotopes. Since direct measurements are often not possible, indirect methods like (d,p) reactions must be used instead. Those (d,p) reactions may be viewed as effective three-body reactions and described with Faddeev techniques. An additional challenge posed by (d,p) reactions involving heavier nuclei is the treatment of the Coulomb force. To avoid numerical complications in dealing with the screening of the Coulomb force, recently a new approach using the Coulomb distorted basis in momentum space was suggested. In order to implement this suggestion, one needs not only to derive a separable representation of neutron- and proton-nucleus optical potentials, but also compute the Coulomb distorted form factors in this basis.

  3. Tracing Distortion Product (DP) Waves in a Cochlear Model

    Science.gov (United States)

    de Boer, Egbert; Shera, Christopher A.; Nuttall, Alfred L.

    2013-01-01

    In many cases a cochlear model suffices to explain (by simulation) the properties of waves in the cochlea. This is not so in the case of a distortion product (DP) set up by presenting two primary tones to the cochlea. A three-dimensional model predicts, apart from a DP wave traveling in the apical direction, a DP wave that travels from the region of overlap of the two tone patterns towards the stapes—setting the stapes in motion so as to produce an otoacoustic emission at the DP frequency. Experimental research has shown, however, that the actual DP wave in the cochlea appears to travel in the opposite direction, from near the stapes to the overlap region. This feature has been termed “inverted direction of wave propagation” (IDWP). The forward wave could result from an unknown process such as a “hidden source” near the stapes. In the present study we have disproved this notion, by using a one-dimensional model of the cochlea. It is found that both reverse and forward waves are set up by the source of nonlinearity, in the same way as has been published in an earlier work. The present results reveal that IDWP in the data corresponds to the region where the DP wave, originally created as a reverse wave but reflected from the stapes, has received so much amplification that it starts to dominate over the reverse wave. Hence we conclude that IDWP in a one-dimensional model is a direct manifestation of cochlear amplification. PMID:25284909

  4. Program Manager: The Journal of the Defense Systems Management College. Volume 12, Number 6, November-December 1983,

    Science.gov (United States)

    1983-12-01

    Division, prime mission equipment acquisition languages in use; and (4) 40 percent of Wright-Patterson AFB, Ohio. He is a process and were designed to...compromising management style or objectives. It em- tems from both the public and private sectors. A synthesis braces a basic language that simplifies... Acqusition at the Defense Communications Agency" by tivity improvement is important to us in defense, then we Fred L. Adler, C. Bruce Baird, and Joseph

  5. Further Evidence on the Effect of Acquisition Policy and Process on Cost Growth of Major Defense Acquisition Programs (Revised)

    Science.gov (United States)

    2016-08-01

    was judged to be practicable and, when not, Fixed Price Incentive Fee (FPIF) or Cost Plus Incentive Fee (CPIF) contracts.6 By 1966, McNamara had...discouraged the use of FPIF for development contracts in favor of CPIF. ( Cost Plus Award Fee may not have been included in the contracting play book yet...Estimate CLC Calibrated Learning Curve CPIF Cost Plus Incentive Fee DAB Defense Acquisition Board DAMIRS Defense Acquisition Management Information

  6. Bake hardening behavior of TRIP and DP steels

    Institute of Scientific and Technical Information of China (English)

    Jicheng Zhang; Renyu Fu; Mei Zhang; Rendong Liu; Xicheng Wei; Lin Li

    2008-01-01

    The bake hardening (BH) behavior of transformation-induced plasticity (TRIP) and dual-phase (DP) steels after different prestrains was studied. The experimental results indicate that TRIP steel exhibits good BH ability while DP steel does not, and prestrain displays a strong effect on the BH values of both steels. The comparison of microstructures of the two steels showed that the hard second phase in the matrix might be harmful to the BH ability. For deformed specimens, baking resulted in a loss of uniform elongation, but there was no obvious decrease in uniform elongation for unprestrained specimens.

  7. Defense gene induction in the compatible interaction of soybean with Cercospora kikuchii and Diaporthe phaseolorum

    Science.gov (United States)

    We examined the compatible interaction of soybean [Glycine max (L.) Merr.] cultivar Dare with fungal pathogens Cercospora kikuchii (CK), a hemibiotroph, and Diaporthe phaseolorum (DP), a biotroph, in order to gain insight into basal host defense. Expression of defense genes in pathogen-, mock-, or ...

  8. Federal Employees Health Benefits (FEHB) program and Department of Defense (DoD) demonstration project; and other miscellaneous changes. Office of Personnel Management. Final rule.

    Science.gov (United States)

    2000-06-08

    OPM is issuing a final regulation to implement the portion of the Defense Authorization Act for 1999 that establishes authority for a demonstration project under which certain Medicare and other eligible DoD beneficiaries can enroll in health benefit plans in certain geographic areas under the Federal Employees Health Benefits (FEHB) Program. The demonstration project will run for a period of three years from January 1, 2000, through December 31, 2002. This regulation specifies only the requirements that differ from existing FEHB Program regulations because of unique aspects of the demonstration project. This regulation also makes other miscellaneous changes to the Federal Employees Health Benefits Acquisition Regulations.

  9. Federal Employees Health Benefits (FEHB) Program and Department of Defense (DoD) demonstration project. Office of Personnel Management. Final rule.

    Science.gov (United States)

    2000-06-02

    OPM is issuing a final regulation to implement the portion of the National Defense Authorization Act for 1999 that establishes authority for a demonstration project under which certain Medicare and other eligible DoD beneficiaries can enroll in health benefit plans in certain geographic areas under the Federal Employees Health Benefits (FEHB) Program. The demonstration project will run for a period of three years from January 1, 2000, through December 31, 2002. This regulation specifies only the requirements that differ from existing FEHB Program regulations because of unique aspects of the demonstration project.

  10. Biological Defense Research Program

    Science.gov (United States)

    1989-04-01

    the data of Babudieri and Moscovici (54), C. burnetii is relatively resistant to ultraviolet rays; however, Siegert et al. (55) showed a marked...four viruses. J. Hyg., Camb. 59:479-484. 54. Babudieri, B., and Moscovici , C. 1952. Bandie Inst. Super. San. 15:215-219. 55. Siegert, R., Peter, H

  11. Investigation of different normalization reactions for dp collisions at ANKE

    Energy Technology Data Exchange (ETDEWEB)

    Fritzsch, Christopher; Guderian, Daniel; Mielke, Malte; Papenbrock, Michael; Schroeer, Daniel; Khoukaz, Alfons [Institut fuer Kernphysik, Westfaelische Wilhelms-Universitaet Muenster (Germany)

    2015-07-01

    Studies on the total cross sections of the reaction d+p → {sup 3}He + η are of special interest since they differ strongly from a pure phase space behaviour near threshold. This behaviour could be an indication for the presence of a quasi bound state of the η{sup 3}He-system. New high precision data from the ANKE spectrometer at the accelerator ring COSY at the Forschungszentrum Juelich allow the extraction of precise total and differential cross section values for the η production up to an excess energy of Q=15 MeV. Therefore, a careful luminosity determination was realized via dp-elastic scattering for 18 beam momenta in a range between 3120.17 MeV/c ≤ p{sub d} ≤ 3204.16 MeV/c. Furthermore, to verify the results of the dp-elastic scattering an independent normalization channel d+p → d+π{sup 0} + p{sub spec} was used. The method and recent results for both channels are presented and discussed.

  12. HLA-DP antigens in HIV-infected individuals

    DEFF Research Database (Denmark)

    Ødum, Niels; Georgsen, J; Fugger, L;

    1991-01-01

    We studied the distribution of HLA-DP antigens in 74 HIV-infected Danish homosexual men and 188 ethnically matched healthy individuals, using the primed lymphocyte typing (PLT) technique. Forty of the patients developed AIDS within 3 years after diagnosis, whereas the remaining 34 were healthy...

  13. Mechanical behavior study of laser welded joints for DP steel

    Science.gov (United States)

    Yan, Qi

    2008-03-01

    Advanced High Strength Steels (AHSS) are gaining considerable market shares in the automotive industry. The development and application of Dual Phase (DP) steel is just a consistent step towards high-strength steel grades with improved mechanical behavior. Tailor welded blanks with DP steel are promoted in the application of Body-In-White (BIW) structure by the automotive industry. A tailor welded blank consists of several flat sheets that are laser welded together before stamping. Applied cases of tailor welded blanks of high strength steels on the automotive structural parts are investigated in this paper. The mechanical behavior of laser welded joints for DP steel is studied. Microstructure of laser welded joints for DP steel was observed by SEM. Martensite in the weld seam explains the higher strength of welded joints than the base metal. Results show that the strain safety tolerance of laser welded seam for high strength steel can meet the requirement of automobile parts for stamping if the location of laser welded seam is designed reasonably.

  14. Hydrologic Resources Management Program and Underground Test Area Project FY 2000 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Davisson, M L; Eaton, G F; Hakemi, N L; Hudson, G B; Hutcheon, I D; Lau, C A; Kersting, A B; Kenneally, J M; Moran, J E; Phinney, D L; Rose, T P; Smith, D K; Sylwester, E R; Wang, L; Williams, R; Zavarin, M

    2001-07-01

    This report highlights the results of FY 2000 technical studies conducted by the Analytical and Nuclear Chemistry Division (ANCD) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrology and Radionuclide Migration Program (HRMP) and Underground Test Area (UGTA) Project. This is the latest in a series of annual reports published by LLNL-ANCD to document recent investigations of radionuclide migration and transport processes at the Nevada Test Site (NTS). The HRMP is sponsored by Defense Programs (DP) at the U.S. Department of Energy, Nevada Operations Office (DOENV), and supports DP operations at the NTS through studies of radiochemical and hydrologic processes that are relevant to the DP mission. Other organizations that support the HRMP include Los Alamos National Laboratory (LANL), the U.S. Geological Survey (USGS), the Desert Research Institute (DRI) of the University of Nevada, the U.S. Environmental Protection Agency (EPS), and Bechtel Nevada (BN). The UGTA Project is sponsored by the Environmental Management (EM) program at DOENV; its goal is to determine the extent of radionuclide contamination in groundwater resulting from underground nuclear testing at the NTS. The project strategy follows guidelines set forth in a Federal Facilities Agreement and Consent Order between the U.S. Department of Energy, the U.S. Department of Defense, and the State of Nevada. Participating contractors include LLNL (both ANCD and the Energy and Environmental Sciences Directorate), LANL, USGS, DRI, BN, and IT Corporation (with subcontract support from Geotrans Inc.).

  15. Optimization of coherent optical OFDM transmitter using DP-IQ modulator with nonlinear response

    Science.gov (United States)

    Chang, Sun Hyok; Kang, Hun-Sik; Moon, Sang-Rok; Lee, Joon Ki

    2016-07-01

    In this paper, we investigate the performance of dual polarization orthogonal frequency division multiplexing (DP-OFDM) signal generation when the signal is generated by a DP-IQ optical modulator. The DP-IQ optical modulator is made of four parallel Mach-Zehnder modulators (MZMs) which have nonlinear responses and limited extinction ratios. We analyze the effects of the MZM in the DP-OFDM signal generation by numerical simulation. The operating conditions of the DP-IQ modulator are optimized to have the best performance of the DP-OFDM signal.

  16. The Effect of a 12-Week Moderate Intensity Interval Training Program on the Antioxidant Defense Capability and Lipid Profile in Men Smoking Cigarettes or Hookah: A Cohort Study

    Directory of Open Access Journals (Sweden)

    Abdessalem Koubaa

    2015-01-01

    Full Text Available Aim. To examine the impact of interval training program on the antioxidant defense capability and lipid profile in men smoking cigarettes or hookah unable or unwilling to quit smoking. Methods. Thirty-five participants performed an interval training (2 : 1 work : rest ratio 3 times a week for 12 weeks at an intensity of 70% of VO2max. All subjects were subjected to a biochemical test session before and after the training program. Results. The increase of total antioxidant status (TAS, glutathione peroxidase (GPx, and α-tocopherol, is significant only for cigarette smokers (CS and hookah smokers (HS groups. The decrease of malondialdehyde (MDA and the increase of glutathione reductase (GR are more pronounced in smokers groups compared to those of nonsmokers (NS. Superoxide dismutase (SOD increases in NS, CS, and HS groups by 10.1%, 19.5%, and 13.3%, respectively (P<0.001. Likewise, a significant improvement of high-density lipoprotein cholesterol (HDL-C and TC/HDL-C ratio was observed in CS and HS groups (P<0.05. Conclusion. Although the interval training program does not have a significant effect on blood lipid levels, it seems to be very beneficial in the defense and prevention programs of oxidative stress.

  17. The HLA-DP polymorphism in Denmark investigated by local and international PLT reagents. Definition of two "new" DP antigens

    DEFF Research Database (Denmark)

    Ødum, Niels; Hartzman, R; Jakobsen, B K

    1986-01-01

    Lymphocytes from highly selected donors were primed for 10 days and subsequently bulk-expanded in IL 2 (TCGF) containing cultures. Two well-discriminatory PLT (CDP = Copenhagen DP) reagents against each of the DPw1-w6 specificities and one against each of the two "new" specificities, CDP4s and CD...

  18. HLA-DP and bone marrow transplantation: DP-incompatibility and severe acute graft versus host disease

    DEFF Research Database (Denmark)

    Ødum, Niels; Platz, P; Jakobsen, B K

    1987-01-01

    Thirteen recipients of HLA-haploidentical, DR compatible bone marrow (BM) and the corresponding BM donors were HLA-DP typed using primed lymphocyte typing (PLT). Severe acute GVHD (greater than or equal to grade 2) developed within 3 months after BM-transplantation in all of eight recipients of D...

  19. Program Manager: Journal of the Defense Systems Management College. Volume 17, Number 4, July-August 1988

    Science.gov (United States)

    1988-08-01

    Senator Phil Gramm, ranking minority member, to advise the Senate Armed Services Committee Defense Industry and , . Technology Subcommittee on "...those... Crosby cisions concerning changes and others have translated to the process. general theories into prac- tical applications that are changing the corporate

  20. Peptide binding predictions for HLA DR, DP and DQ molecules

    DEFF Research Database (Denmark)

    Wang, P.; Sidney, J.; Kim, Y.

    2010-01-01

    a significant gap in knowledge as HLA DP and DQ molecules are presumably equally important, and have only been studied less because they are more difficult to handle experimentally. RESULTS: In this study, we aimed to narrow this gap by providing a large scale dataset of over 17,000 HLA-peptide binding......BACKGROUND: MHC class II binding predictions are widely used to identify epitope candidates in infectious agents, allergens, cancer and autoantigens. The vast majority of prediction algorithms for human MHC class II to date have targeted HLA molecules encoded in the DR locus. This reflects...... their performance. CONCLUSION: We found that 1) prediction methodologies developed for HLA DR molecules perform equally well for DP or DQ molecules. 2) Prediction performances were significantly increased compared to previous reports due to the larger amounts of training data available. 3) The presence...

  1. A Lightweight Approach to Performance Portability with targetDP

    CERN Document Server

    Gray, Alan

    2016-01-01

    Leading HPC systems achieve their status through use of highly parallel devices such as NVIDIA GPUs or Intel Xeon Phi many-core CPUs. The concept of performance portability across such architectures, as well as traditional CPUs, is vital for the application programmer. In this paper we describe targetDP, a lightweight abstraction layer which allows grid-based applications to target data parallel hardware in a platform agnostic manner. We demonstrate the effectiveness of our pragmatic approach by presenting performance results for a complex fluid application (with which the model was co-designed), plus a separate lattice QCD particle physics code. For each application, a single source code base is seen to achieve portable performance, as assessed within the context of the Roofline model. TargetDP can be combined with MPI to allow use on systems containing multiple nodes: we demonstrate this through provision of scaling results on traditional and GPU-accelerated large scale supercomputers.

  2. Superconductor-insulator transition in the d-p model

    CERN Document Server

    Arimoto, T; Tsuruta, A; Kobayashi, A; Kuroda, Y

    2003-01-01

    We investigate a transition between the superconducting phase and the Mott insulator phase in the d-p model by using the slave-boson method and the 1/N-expansion theory, where the pairing interaction is given by the superexchange interaction J sub s. We show that the competition between the pairing interaction and the Fermi energy induces the transition at finite doping rate. (author)

  3. BEHAVIOR OF STEEL DP 600 UNDER DYNAMIC CONDITIONS

    Directory of Open Access Journals (Sweden)

    Miroslav Német

    2014-01-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 Dynamic tensile testing of sheet steels is becoming more important. Experimental dynamic tensile technique is depending on the strain rate. For experiments was used two testing method servo hydraulic and single bar method. Experiments was realized on steel grade DP 600. Steel were performed and evaluated static and dynamic tests. Was investigated substructure in static and dynamic loading conditions.

  4. Separable Forces for $(d,p)$ Reactions in Momentum Space

    CERN Document Server

    Hlophe, L; Eremenko, V; Nunes, F M; Thompson, I J; Arbanas, G; Escher, J

    2015-01-01

    Treating $(d,p)$ reactions in a Faddeev-AGS framework requires the interactions in the sub-systems as input. We derived separable representations for the neutron- and proton-nucleus interactions from phenomenological global optical potentials. In order to take into account excitations of the nucleus, excitations need to be included explicity, leading to a coupled-channel separable representation of the optical potential.

  5. Open parabosonic string theory between two parallel Dp-branes

    Energy Technology Data Exchange (ETDEWEB)

    Hamam, D.; Belaloui, N. [Laboratoire de Physique Theorique, Universite de Jijel (Algeria); Laboratoire de Physique Mathematique et Subatomique, Universite Mentouri Constantine (Algeria)

    2012-06-27

    We investigate an open parabosonic string theory between two parallel Dp-branes. The spectrum is constructed and the partition function is derived. A common chord between the development of this latter and the degeneracy of the states for each mass level is obtained. The theory is consistent and with no tachyon. The Virasoro algebra is derived and compared to the one of the ordinary case.

  6. DP systems for offshore vessel positioning in deep water

    OpenAIRE

    2013-01-01

    Current industry practices and the suggestions from the literature are that offshore oil exploration and production activities will move into deeper water further from shore. To achieve that, dynamic positioning systems are indispensible. In the past 5 years, there has been a dramatic increase in the number of offshore installations equipped with DP systems. This thesis is focused on comprehensive characteristics, utilities, risk analysis and future trends regarding positioning systems in...

  7. Geometrical precision of 3DP casting form for founding gears

    Directory of Open Access Journals (Sweden)

    T. Markowski

    2010-01-01

    Full Text Available The article presents analysis of geometrical precision of casting form made by means of 3DP method. Three dimentional printing is a universal method of rapid prototyping which can be used to make tools – castings forms as a Rapid Tooling method. By means of this method in direct incremental process a casting form of spur gear was created. Precision of creating the form by 3DP method depends on different factors. Technological factors depending on machine operator include: the thickness of the layer and placing the model in working space. The precision of creating the model also depends on preparing the printer for work: the condition and calibration of printing heads, the condition of the printing unit slide guides and preparing the working space. Three dimentional printer Z510 Spectrum was prepared for work in a way assuring the greatest precision of created models. Technological parameters responsible for precision were set on maximum values. The aim of the research was defining the precision of casting form generated by 3DP Rapid Prototyping Method. The research was made by means of coordinate measuring machine Wenzel LH87. The measuring machine software was used to compare the outcome of the measurement to nominal model 3D-CAD. The problem of tool precision of casting forms generated by Rapid Tooling is rarely considered in literature covering rapid prototyping and casting technologies. That is why the research presented in this article isan original work in the technological and practical aspect.

  8. The Arctic DP Research Project: Effective Stationkeeping in Ice

    Directory of Open Access Journals (Sweden)

    Roger Skjetne

    2014-10-01

    Full Text Available Stress on the environment from a potentially growing energy use is set to rise. Without doubt the energy resources in Arctic regions will be developed. An important goal will be to exploit the resources offered by for instance the Barents Sea as a new European energy province, and to do this in accordance with the principles of sustainable development that have successfully been used e.g. in the North Sea. The special edition of MIC on Arctic DP presents a set of articles that summarize to an extent the activities of the research project Arctic DP: Safe and green dynamic positioning operations of offshore vessels in an Arctic environment. This project was awarded in 2010 by the Research Council of Norway (RCN as a competence-building project (KMB project to NTNU and its partners Kongsberg Maritime, DNV GL, and Statoil. The objective was to target some of the challenges related to safe Arctic offshore operations by dynamic positioning. In this first article of the Arctic DP special edition we discuss the background for and establishment of the project, its planning and execution, and project closure. An overview is given for the scientific and engineering research performed in the project, with an account of what we have considered as Effective stationkeeping in ice by dynamic positioning. The corresponding research activities conducted under this main theme is summarized.

  9. Mobilization and Defense Management Technical Report Series. Effective Integration of Faculty Requirements into Army System Acquisition Programs.

    Science.gov (United States)

    1983-05-01

    authors and does not necessarily reflect the official opinion of the Industrial College of the Acmd ftrces, The National Defense University, or the...good management requirements by the Army or in response to directives from OSD) appear to be generally sufficient to guide the general execution of...significant f. astasiw . gmAt efforts are necessary to minimise these 9j. go NK has no responsibility for execution of facilities construction on ;I in

  10. Program Manager: The Journal of the Defense Systems Management College. Volume 12, Number 3, May-June 1983.

    Science.gov (United States)

    1983-01-01

    service groups, education, and professional organiza- tions. When we apply the ratio, we usually express it as an busine index in which the current...financial leverage. accept artificially low contract profits, he will react by striv- ing to increase profitability. This translates into low levels...Officer, MCC Corporation, and former deputy cited Refe e director of the Central Intelligence Agency. 1. On April 30, 1981, Deputy Secretary of Defense

  11. Defense Research Enterprise Assessment

    Science.gov (United States)

    2017-01-01

    Please review the report findings and recommendations. I am interested in receiving your feedback for inclusion in programs wherever these...needed culture shift to utilize their existing authorities. Finally, expanded coordination among intermural basic research portfolios across the Labs...research portfolios across the Labs without creating additional administrative burdens is needed. The defense research enterprise should

  12. Department of Defense Healthcare Management System Modernization (DHMSM)

    Science.gov (United States)

    2016-03-01

    2016 Major Automated Information System Annual Report Department of Defense Healthcare Management System Modernization (DHMSM) Defense...Secretary of Defense PB - President’s Budget RDT&E - Research, Development, Test, and Evaluation SAE - Service Acquisition Executive TBD - To Be...DSN Fax: Date Assigned: November 16, 2015 Program Information Program Name Department of Defense Healthcare Management System Modernization

  13. Neural substrates of defensive reactivity in two subtypes of specific phobia.

    Science.gov (United States)

    Lueken, Ulrike; Hilbert, Kevin; Stolyar, Veronika; Maslowski, Nina I; Beesdo-Baum, Katja; Wittchen, Hans-Ulrich

    2014-11-01

    Depending on threat proximity, different defensive behaviours are mediated by a descending neural network involving forebrain (distal threat) vs midbrain areas (proximal threat). Compared to healthy subjects, it can be assumed that phobics are characterized by shortened defensive distances on a behavioural and neural level. This study aimed at characterizing defensive reactivity in two subtypes of specific phobia [snake (SP) and dental phobics (DP)]. Using functional magnetic resonance imaging (fMRI), n = 39 subjects (13 healthy controls, HC; 13 SP; 13 DP) underwent an event-related fMRI task employing an anticipation (5-10 s) and immediate perception phase (phobic pictures and matched neutral stimuli; 1250 ms) to modulate defensive distance. Although no differential brain activity in any comparisons was observed in DP, areas associated with defensive behaviours (e.g. amygdala, hippocampus, midbrain) were activated in SP. Decreasing defensive distance in SP was characterized by a shift to midbrain activity. Present findings substantiate differences between phobia types in their physiological and neural organization that can be expanded to early stages of defensive behaviours. Findings may contribute to a better understanding of the dynamic organization of defensive reactivity in different types of phobic fear.

  14. Defense Acquisition Policy and Defense Industrial Base Reinforcement Strategy - Enhancing the International Competitiveness of the Korean National Defense Industry

    Science.gov (United States)

    2008-04-23

    Korea Defense Industry Association (KDIA). (2007). Annual management review of Korean Defense Industry. Seoul: Author. Lee, D.O. (2000...COMPETITIVENESS OF THE KOREAN NATIONAL DEFENSE INDUSTRY Published: 23 April 2008 by Dr. Dae Ok Lee 5th Annual Acquisition Research Symposium of the...International Competitiveness of the Korean National Defense Industry 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

  15. Knockdown of dystrophin Dp71 impairs PC12 cells cycle: localization in the spindle and cytokinesis structures implies a role for Dp71 in cell division.

    Directory of Open Access Journals (Sweden)

    Marcela Villarreal-Silva

    Full Text Available The function of dystrophin Dp71 in neuronal cells remains to be established. Previously, we revealed the involvement of this protein in both nerve growth factor (NGF-induced neuronal differentiation and cell adhesion by isolation and characterization of PC12 neuronal cells with depleted levels of Dp71. In this work, a novel phenotype of Dp71-knockdown cells was characterized, which is their delayed growth rate. Cell cycle analyses revealed an altered behavior of Dp71-depleted cells, which consists of a delay in G0/G1 transition and an increase in apoptosis during nocodazole-induced mitotic arrest. Dp71 associates with lamin B1 and β-dystroglycan, proteins involved in aspects of the cell division cycle; therefore, we compared the distribution of Dp71 with that of lamin B1 and β-dystroglycan in PC12 cells at mitosis and cytokinesis by means of immunofluorescence and confocal microscopy analysis. All of these three proteins exhibited a similar immunostaining pattern, localized at mitotic spindle, cleavage furrow, and midbody. It is noteworthy that a drastic decreased staining in mitotic spindle, cleavage furrow, and midbody was observed for both lamin B1 and β-dystroglycan in Dp71-depleted cells. Furthermore, we demonstrated the interaction of Dp71 with lamin B1 in PC12 cells by immunoprecipitation and pull-down assays, and importantly, we revealed that knockdown of Dp71 expression caused a marked reduction in lamin B1 levels and altered localization of the nuclear envelope protein emerin. Our data indicate that Dp71 is a component of the mitotic spindle and cytokinesis multi-protein apparatuses that might modulate the cell division cycle by affecting lamin B1 and β-dystroglycan levels.

  16. In silico analyses of dystrophin Dp40 cellular distribution, nuclear export signals and structure modeling

    Directory of Open Access Journals (Sweden)

    Alejandro Martínez-Herrera

    2015-09-01

    Full Text Available Dystrophin Dp40 is the shortest protein encoded by the DMD (Duchenne muscular dystrophy gene. This protein is unique since it lacks the C-terminal end of dystrophins. In this data article, we describe the subcellular localization, nuclear export signals and the three-dimensional structure modeling of putative Dp40 proteins using bioinformatics tools. The Dp40 wild type protein was predicted as a cytoplasmic protein while the Dp40n4 was predicted to be nuclear. Changes L93P and L170P are involved in the nuclear localization of Dp40n4 protein. A close analysis of Dp40 protein scored that amino acids 93LEQEHNNLV101 and 168LLLHDSIQI176 could function as NES sequences and the scores are lost in Dp40n4. In addition, the changes L93/170P modify the tertiary structure of putative Dp40 mutants. The analysis showed that changes of residues 93 and 170 from leucine to proline allow the nuclear localization of Dp40 proteins. The data described here are related to the research article entitled “EF-hand domains are involved in the differential cellular distribution of dystrophin Dp40” (J. Aragón et al. Neurosci. Lett. 600 (2015 115–120 [1].

  17. Role of core excitation in (d,p) transfer reactions

    CERN Document Server

    Deltuva, A; Norvaišas, E; Nunes, F M

    2016-01-01

    [Background:] Recent work found that core excitation can be important in extracting structure information from (d,p) reactions. [Purpose:] Our objective is to systematically explore the role of core excitation in (d,p) reactions, and understand the origin of the dynamical effects. [Method:] Based on the particle-rotor model of $n+^{10}$Be, we generate a number of models with a range of separation energies ($S_n=0.1-5.0$ MeV), while maintaining a significant core excited component. We then apply the latest extension of the momentum-space based Faddeev method, including dynamical core excitation in the reaction mechanism to all orders, to the $^{10}$Be(d,p)$^{11}$Be like reactions, and study the excitation effects for beam energies from $E_d=15-90$ MeV. [Results:] We study the resulting angular distributions and the differences between the spectroscopic factor that would be extracted from the cross sections, when including dynamical core excitation in the reaction, to that of the original structure model. We al...

  18. Visualizing molecular profiles of glioblastoma with GBM-BioDP.

    Directory of Open Access Journals (Sweden)

    Orieta Celiku

    Full Text Available Validation of clinical biomarkers and response to therapy is a challenging topic in cancer research. An important source of information for virtual validation is the datasets generated from multi-center cancer research projects such as The Cancer Genome Atlas project (TCGA. These data enable investigation of genetic and epigenetic changes responsible for cancer onset and progression, response to cancer therapies, and discovery of the molecular profiles of various cancers. However, these analyses often require bulk download of data and substantial bioinformatics expertise, which can be intimidating for investigators. Here, we report on the development of a new resource available to scientists: a data base called Glioblastoma Bio Discovery Portal (GBM-BioDP. GBM-BioDP is a free web-accessible resource that hosts a subset of the glioblastoma TCGA data and enables an intuitive query and interactive display of the resultant data. This resource provides visualization tools for the exploration of gene, miRNA, and protein expression, differential expression within the subtypes of GBM, and potential associations with clinical outcome, which are useful for virtual biological validation. The tool may also enable generation of hypotheses on how therapies impact GBM molecular profiles, which can help in personalization of treatment for optimal outcome. The resource can be accessed freely at http://gbm-biodp.nci.nih.gov (a tutorial is included.

  19. Modeling of Intercritical Heat Treatment of DP and TRIP Steels

    Institute of Scientific and Technical Information of China (English)

    REGER Mihaly; VERO Balazs; CSEPELI Zsolt; PAN Jiansheng

    2004-01-01

    The final microstructure of DP and TRIP assisted steels can evolve after hot working (hot rolling) or during post heat treatment process. In the formation of the final structure a number of different technological parameters have important roles, e.g. end temperature of rolling, cooling rates, temperature of intercritical annealing, etc. As a result of the individual factors and their combinations a lot of product technology routes are feasible. The effect of the different combinations of these technological parameters on the microstructure can be mapped by the special Jominy end-quench test (so called intercritical Jominy end-quench test) described in this paper. Unlike the traditional Jominy test, in this case there is a partial anstenizing between A1 and A3 temperatures which results in a given amount of ferrite in the microstructure before quenching. The method developed can be applied for mapping DP and TRIP assisted steels' microstructure in a wide range of technological parameters. The analysis of measured and calculated data can help us find the technological parameters optimal from the microstructural point of view.

  20. Modeling of Intercritical Heat Treatment of DP and TRIP Steels

    Institute of Scientific and Technical Information of China (English)

    REGERMihaly; VEROBalazs; CSEPELIZsolt; PANJiansheng

    2004-01-01

    The final microstructure of DP and TRIP assisted steels can evolve after hot working (hot rolling) or during post heat treatment process. In the formation of the final structure a number of different technological parameters have important roles, e.g. end temperature of rolling, cooling rates, temperature of intercritical annealing, etc. As a result of the individual factors and their combinations a lot of product technology routes are feasible. The effect of the different combinations of these technological parameters on the microstructure can be mapped by the special Jominy end-quench test (so called intercritical Jominy end-quench test) described in this paper. Unlike the traditional Jominy test, in this case there is a partial austenizing between A1 and A3 temperatures which results in a given amount of ferrite in the microstructure before quenching. The method developed can be applied for mapping DP and TRIP assisted steels' microstructure in a wide range of technological parameters. The analysis of measured and calculated data can help us find the technological parameters optimal from the microstructural point of view.

  1. Program Manager: Journal of the Defense Systems Management College. Volume 23, Number 1, January-February 1994

    Science.gov (United States)

    1994-02-01

    Jones, Jr. PROGRAM MANAGER Managing Editor Esther M. Farria Art Director Greg Caruth Typography and Design Paula Croisetlere Program Manager (ISSN 0199...Company bombers to implement the strategic organization - President Clayton 1. Brukner commu- bombing doctrine. This would take all brand -new cre

  2. U.S. Department of Energy Space and Defense Power Systems Program Ten-Year Strategic Plan, Volume 1 and Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Dwight, Carla

    2013-06-01

    The Department of Energy's Space and Defense Power Systems program provides a unique capability for supplying power systems that function in remote or hostile environments. This capability has been functioning since the early 1960s and counts the National Aeronautics and Space Administration as one of its most prominent customers. This enabling technology has assisted the exploration of our solar system including the planets Jupiter, Saturn, Mars, Neptune, and soon Pluto. This capability is one-of-kind in the world in terms of its experience (over five decades), breadth of power systems flown (over two dozen to date) and range of power levels (watts to hundreds of watts). This document describes the various components of that infrastructure, work scope, funding needs, and its strategic plans going forward.

  3. Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor.

    Directory of Open Access Journals (Sweden)

    Pascale Labrecque

    Full Text Available Prostaglandin D₂ (PGD₂ acts through two G protein-coupled receptors (GPCRs, the prostanoid DP receptor and CRTH2 also known as DP1 and DP2, respectively. Several previously characterized GPCR antagonists are now classified as inverse agonists and a number of GPCR ligands are known to display pharmacochaperone activity towards a given receptor. Here, we demonstrate that a DP1 specific antagonist, MK-0524 (also known as laropiprant, decreased basal levels of intracellular cAMP produced by DP1, a Gα(s-coupled receptor, in HEK293 cells. This reduction in cAMP levels was not altered by pertussis toxin treatment, indicating that MK-0524 did not induce coupling of DP1 to Gα(i/o proteins and that this ligand is a DP1 inverse agonist. Basal ERK1/2 activation by DP1 was not modulated by MK-0524. Interestingly, treatment of HEK293 cells expressing Flag-tagged DP1 with MK-0524 promoted DP1 cell surface expression time-dependently to reach a maximum increase of 50% compared to control after 24 h. In contrast, PGD₂ induced the internalization of 75% of cell surface DP1 after the same time of stimulation. The increase in DP1 cell surface targeting by MK-0524 was inhibited by Brefeldin A, an inhibitor of transport from the endoplasmic reticulum-Golgi to the plasma membrane. Confocal microscopy confirmed that a large population of DP1 remained trapped intracellularly and co-localized with calnexin, an endoplasmic reticulum marker. Redistribution of DP1 from intracellular compartments to the plasma membrane was observed following treatment with MK-0524 for 24 h. Furthermore, MK-0524 promoted the interaction between DP1 and the ANKRD13C protein, which we showed previously to display chaperone-like effects towards the receptor. We thus report that MK-0524 is an inverse agonist and a pharmacochaperone of DP1. Our findings may have important implications during therapeutic treatments with MK-0524 and for the development of new molecules targeting DP1.

  4. Evidence on the Effect of DoD Acquisition Policy and Process on Cost Growth of Major Defense Acquisition Programs

    Science.gov (United States)

    2014-09-01

    reports the number of programs with an average PAUC growth of at least 50 percent. Of the fifty -four programs that passed MS II/B in a Relatively...six cases ( shaded rows). In all but one of these cases (Joint Direct Attack Munition, or JDAM) the differences are absolutely or relatively small. The...same pattern. The average of the DLC estimates is 73 percent, and four of them ( shaded rows) are less than the PA&E estimate for the program, three

  5. A Computer-Aided Instruction Program for Teaching the TOPS20-MM Facility on the DDN (Defense Data Network)

    Science.gov (United States)

    1988-06-01

    provide learning-by-doing, which means a student aquires knowledge by solving real-world problems [Ref. 21. To tutor well, a system has to specify...apply artificial intelligence (AI) techniques. AI research such as natural- language understanding, knowledge representation, and inferencing, have been...programming language by providing a programming environment and online help facility. It has a tutoring module called Soft Tutor that examines the

  6. REMOTE IN-CELL SAMPLING IMPROVEMENTS PROGRAM AT THESAVANNAH RIVER SITE (SRS) DEFENSE WASTE PROCESSING FACILITY (DWPF)

    Energy Technology Data Exchange (ETDEWEB)

    Marzolf, A

    2007-11-26

    Remote Systems Engineering (RSE) of the Savannah River National Lab (SRNL) in combination with the Defense Waste Processing Facility(DWPF) Engineering and Operations has evaluated the existing equipment and processes used in the facility sample cells for 'pulling' samples from the radioactive waste stream and performing equipment in-cell repairs/replacements. RSE has designed and tested equipment for improving remote in-cell sampling evolutions and reducing the time required for in-cell maintenance of existing equipment. The equipment within the present process tank sampling system has been in constant use since the facility start-up over 17 years ago. At present, the method for taking samples within the sample cells produces excessive maintenance and downtime due to frequent failures relative to the sampling station equipment and manipulator. Location and orientation of many sampling stations within the sample cells is not conducive to manipulator operation. The overextension of manipulators required to perform many in-cell operations is a major cause of manipulator failures. To improve sampling operations and reduce downtime due to equipment maintenance, a Portable Sampling Station (PSS), wireless in-cell cameras, and new commercially available sampling technology has been designed, developed and/or adapted and tested. The uniqueness of the design(s), the results of the scoping tests, and the benefits relative to in-cell operation and reduction of waste are presented.

  7. Predictive value of self-reported and observer-rated defense style in depression treatment.

    Science.gov (United States)

    Van Henricus, L; Dekker, Jack; Peen, Jaap; Abraham, Robert E; Schoevers, Robert

    2009-01-01

    This study explored the predictive value of observer-rated and self-reported defensive functioning on the outcome of psychotherapy for the treatment of depression. Defense styles were measured according to the Developmental Profile (DP) and the Defense Style Questionnaire (DSQ) in 81 moderately severely depressed patients. All patients were treated with Short-term Psychodynamic Supportive Psychotherapy (SPSP). At baseline, women appeared to have a more mature level of overall defensive functioning. A lower level of defensive function was found in patients with recurrent depressions. We also found a rather modest relationship between self-reported and observer-rated defense. Remitted patients had a more mature overall defensive functioning on the DP and the DSQ. In particular, patients with a symbiotic defense style (giving up, apathetic withdrawal) were at risk for poor outcome. This exploratory study provides further evidence of the relevance of defense styles for depression. It suggests a differential predictive value of separate defense levels, which may help to tailor psychotherapeutic strategies.

  8. Night-side DP2 Fluctuation Observed MAGDAS/CPMN Network

    Science.gov (United States)

    Imamura, K.; Shinohara, M.; Yumoto, K.

    2008-12-01

    DP2 caused by IMF southward/northward variations has important information about how the solar wind effects are transferred into the magnetosphere, and ionosphere, and on the ground. Since dayside ground magnetic field variations are significantly enhanced during DP2, dayside DP2 fluctuations have been investigated for ages. But night-side DP2 variations are not investigated enough yet. As a new approach to DP2, in this study we examined night-side magnetic variations when DP2 occurred in dayside. Ground data from MAGnetic Data Acqisition System and Circum-pan Pacific Magnetometer Network (MAGDAS/CPMN) stations were analyzed. To identify dayside DP2 events, we used the records of stations located at the dip equator. The association of DP2 with the solar wind variations, magnetic and velocity data from the ACE satellite were investigated. The obtained results by statistical analysis can be summarized as follows. (1) About half (82/153) of the dayside DP2 events are found to accompany the night-side DP2 with similar wave form. (2) The amplitude of the night-side variation (which correlates with the dayside DP2) shows a good correlation with the intensity of the dawn-to-dusk electric field in the solar wind. In the present paper, we will discuss a generation mechanism of the night-side DP2 for a case study. Acknowledgments. We would like to thank the organization for cooperating MAGDAS/CPMN project; Commodore Rodolfo M. Agaton (Director, CGSD, Coast and Geodetic Survey Department, Mutinlupa), Dr. Mazlan Othman (Director General of National Space Agency, Langkawi), Fr. Daniel McNamara (Director, Manila Observatory, Davao), Dr. David Aranug (Director, Weather Service Office YAP, Yap), Dr. Ronald Woodman Pollitt (Presidente Ejecutivo Instituto Geofisico del Peru, Ancon), Dr. Baylie Damtie (IHY National Coordinator in Ethiopia, Dept. of Physics, Bahir Dar University, Addis Ababa).

  9. The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking

    DEFF Research Database (Denmark)

    Schratl, Petra; Royer, Julia F; Kostenis, Evi

    2007-01-01

    of DP has remained unclear. We report in this study that, in addition to CRTH2, the DP receptor plays an important role in eosinophil trafficking. First, we investigated the release of eosinophils from bone marrow using the in situ perfused guinea pig hind limb preparation. PGD2 induced the rapid...... that eosinophils in human bone marrow specimens expressed DP and CRTH2 receptors at similar levels. Eosinophils isolated from human peripheral blood likewise expressed DP receptor protein but at lower levels than CRTH2. In agreement with this, the chemotaxis of human peripheral blood eosinophils was inhibited both...

  10. Three Approaches to Space Systems Acquisitions and their Application to the Defense Department’s Weather Satellite Program

    Science.gov (United States)

    2012-03-01

    by Toyota in the manufacturing world, such as just-in-time, kaizen , one-piece flow, jidoka, and heijunka. These techniques helped spawn the “lean...relentless reflection (hansei) and continuous improvement ( kaizen ) Similar to Principle 2, this principle shares similarity with space program

  11. Program Manager: Journal of the Defense Systems Management College, Volume 22, Number 5, September-October 1993

    Science.gov (United States)

    1993-10-01

    PROGRAM MANAGER Mangig diorPARADIGM SHIFT Catherine M. Clark Associate Editor E Esther M. Farria Art Director Greg Caruth Typography and Design Paula...Director, DSMC showing the title, author, TR number and DSMC logo Press, for publication consideration. No prearrange- and similar title page. ments are

  12. 77 FR 35432 - Privacy Act of 1974, Computer Matching Program: United States Postal Service and the Defense...

    Science.gov (United States)

    2012-06-13

    ... Numbers, names, and dates of birth for TRS-enrolled Selected Reservists or TRR-enrolled Retired Reservists.... TRS Program--TRICARE Reserve Select, a premium based TRICARE military health plan for members of the... Retired Reserve, a premium based TRICARE military health plan for members of the Retired Reserve of...

  13. Acquisition Program Risk Management: Does the Department of Defense Risk Management Practices Guide Provide an Effective Risk Tool for Program Managers in Today’s Acquisition Environment?

    Science.gov (United States)

    2012-05-01

    Management Definition ........................................................................................... 32 Table 16. Risk Management Tracking...Other (please specify) 5 Table 15. Risk Management Definition Question 7: Does your Program Office or Risk Management IPT track risks for cost...aligned to collect information on program risk definition. Question 6 was designed to collect information on risk management definition . Participants

  14. Further Evidence on the Effect of Acquisition Policy and Process on Cost Growth of Major Defense Acquisition Programs

    Science.gov (United States)

    2016-06-01

    Acquisition Reform, 1969 to 2009, 38, following Gordon Adams, Paul Murphy, and William Grey Rosenau, Controlling Weapons Costs: Can Pentagon Reforms Work...New York: Council on Economic Priorities, 1983), 19–20. A TPP contract is one that covers EMD, at least a significant portion of procurement, and...mechanism for ongoing managerial control.” This is accurate in that the Packard reforms placed management of the programs in the hands of the Services

  15. Program Manager: Journal of the Defense Systems Management College, Volume 19, Number 6, November-December 1990

    Science.gov (United States)

    1990-12-01

    rejuvenated you’ll hear they are genuinely proud Western European Union (WEU) is # to be part of this determincd move- asserting itself as a unifying force I...corresponding to their vital interests economies through the benefits of for operating an open Europea , and their possibilities. Therefore open competition...EUROPEAN EUROPEAN COMMUNITY PROGRAM UNION GROUP COMMON REQUIREMENTS CAPS PANEL1 (ECONOMIES OF SCALE) I AND PROJECT I COORDINATION I (REDUCTION OF

  16. Further Evidence on the Effect of Acquisition Policy and Process on Cost Growth of Major Defense Acquisition Programs

    Science.gov (United States)

    2016-06-01

    account parallel analyses for the boom periods and the comparisons of cost growth in bust and boom periods for a given acquisition regime (Appendix E...funds. Only the former are used in computing quantity- adjusted RDT&E cost growth. Our procedure was simply to compute the ratio of the Current ...Group CAPE Cost Assessment and Program Evaluation CD Compact Disc CE Current Estimate CLC Calibrated Learning Curve CPIF Cost Plus Incentive Fee

  17. Efforts and Programs of the Department of Defense Relating to the Prevention, Mitigation, and Treatment of Blast Injuries

    Science.gov (United States)

    2007-01-01

    Regeneration of Orthopedic Tissues for Military Applications: This project tests LifeCell’s hybrid ACL ( anterior cruciate ligament ) graft using a...of prosthetic technology and improvement in occupational and physical therapies . These efforts will leverage the three DoD Amputee Centers as...events. Extremity • Rehabilitation – Therapy : Conduct more physical and occupational therapy research. Efforts and Programs of the Department of

  18. Program Manager - Journal of the Defense Systems Management College, Volume 24, Number 1, DSMC 124, January-February 1995.

    Science.gov (United States)

    1995-02-01

    and avi- contingencies, in the continental (Ret) Marquez ). onics equipment! We’re also relieved United States (CONUS) and over- of the need to put 50...TO THE EDITOR I read with interest the short discussion in the jul- Staff General Gabriel and then Secretary of the Air Aug 94 issue of Program...p. 21. Garcia , p. 17. * Why DoD Should Move Toward Commercial * Evolution of Configuration Management-William J. Practices-Dr. Walter B. LaBerge, p

  19. A valoração de traços de concordância dentro do DP Concord features valuing within DP

    Directory of Open Access Journals (Sweden)

    Telma M.V. Magalhães

    2004-06-01

    Full Text Available Este trabalho argumenta em favor da valoração dos traços de concordância dentro do DP em termos da operação Agree (Chomsky, 1999 sem a necessidade de estipular nenhum outro mecanismo para tanto. Mostro que Agree dá conta da valoração de traços tanto no nível da sentença quanto no nível do DP, contra a sugestão de Chomsky (1999 de que concordância no DP envolveria algum outro mecanismo de checagem.This paper argues in favor of a concord features valuing within the DP in terms of the Agree operation (Chomsky, 1999, with no recourse to any other mechanism. I show that Agree accounts for feature valuing both in the sentence level as well as in the DP, contrary to Chomsky's (1999 suggestion that concord in DP should involve some other checking mechanism.

  20. Deuteron Induced ( d,p) and ( d,2p) Nuclear Reactions up to 50 MeV

    Science.gov (United States)

    Yiğit, M.; Tel, E.; Kara, A.

    2013-06-01

    Many studies have shown that the nuclear reactions of charged particles with nuclei are very important in many fields of nuclear physics. The interactions of deuterons with nuclei have been especially the subject of common research in the history of nuclear physics. Moreover, the knowledge of cross section for deuteron-nucleus interactions are required for various application such as space applications, accelerator driven sub-critical systems, nuclear medicine, nuclear fission reactors and controlled thermonuclear fusion reactors. Particularly, the future of controlled thermonuclear fusion reactors is largely dependent on the nuclear reaction cross section data and the selection of structural fusion materials. Finally, the reaction cross section data of deuteron induced reactions on fusion structural materials are of great importance for development and design of both experimental and commercial fusion devices. In this work, reaction model calculations of the cross sections of deuteron induced reactions on structural fusion materials such as Al ( Aluminium), Ti ( Titanium), Cu ( Copper), Ni ( Nickel), Co ( Cobalt), Fe ( Iron), Zr ( Zirconium), Hf ( Hafnium) and Ta ( Tantalum) have been investigated. The new calculations on the excitation functions of 27 Al( d,2p) 27 Mg, 47 Ti( d,2p) 47 Sc, 65 Cu( d,2p) 65 Ni, 58 Ni( d,2p) 58 Co, 59 Co( d,2p) 59 Fe, 58 Fe( d,p) 59 Fe, 96 Zr( d,p) 97 Zr, 180 Hf ( d,p) 181 Hf and 181 Ta( d,p) 182 Ta have been carried out for incident deuteron energies up to 50 MeV. In these calculations, the equilibrium and pre-equilibrium effects for ( d,p) and ( d,2p) reactions have been investigated. The equilibrium effects are calculated according to the Weisskopf-Ewing ( WE) Model. The pre-equilibrium calculations involve the new evaluated the Geometry Dependent Hybrid Model ( GDH) and Hybrid Model. In the calculations the program code ALICE/ASH was used. The calculated results are discussed and compared with the experimental data taken from the

  1. HLA-DP antigens are involved in the susceptibility to multiple sclerosis

    DEFF Research Database (Denmark)

    Ødum, Niels; Hyldig-Nielsen, J J; Morling, N;

    1988-01-01

    Forty-five unrelated patients with multiple sclerosis (MS) from Sweden and 166 Danish controls were typed for HLA-DP using Primed Lymphocyte Typing. Thirty-nine MS-patients and 63 controls were also DNA-typed with the Restriction Fragment Length Polymorphism (RFLP) technique for HLA-DP and -DR ge...

  2. HLA-DP related suppression of mixed lymphocyte reaction with alloactivated lymphocytes

    DEFF Research Database (Denmark)

    Ødum, Niels; Hofmann, B; Jakobsen, B K

    1986-01-01

    We studied the influence of HLA class I and class II antigens on the suppression of the MLR induced by primed lymphocytes (PLs) alloactivated in vitro. The suppression of 14 different PLs of 83 MLRs was analyzed. The PLs were primed against (i) HLA-DP (SB) (ii) HLA-DR/DQ or (iii) both HLA-DP and DR...

  3. Restriction fragment polymorphism (RFLP) of a "new" HLA-DP specificity, CDP-HEI

    DEFF Research Database (Denmark)

    Hyldig-Nielsen, J J; Ødum, Niels; Morling, Niels;

    1988-01-01

    Southern blotting with a DP beta cDNA probe of MspI digested DNA from 83 healthy unrelated individuals revealed a 1.8 kb fragment present in all four individuals (and no others) possessing the newly determined DP specificity, CDP-HEI....

  4. 75 FR 10317 - DHL Global Forwarding, A Subsidiary of DP DHL, Finance and Accounting Divisions, Including...

    Science.gov (United States)

    2010-03-05

    ... Plantation, FL; DHL Global Forwarding, A Subsidiary of DP DHL, Finance and Accounting Divisions, Including... Forwarding, A Subsidiary of DP DHL Finance and Accounting Divisions, Including Workers Whose Wages Are..., Finance and Accounting Divisions, Including Workers Whose Wages Are Reported to Danzas, Radix and...

  5. A Scenario Tree based Stochastic Programming Approach for Multi-Stage Weapon Equipment Mix Production Planning in Defense Manufacturing

    Directory of Open Access Journals (Sweden)

    Li Xuan

    2016-01-01

    Full Text Available The evolving military capability requirements (CRs must be meted continuously by the multi-stage weapon equipment mix production planning (MWEMPP. Meanwhile, the CRs possess complex uncertainties with the variant military tasks in the whole planning horizon. The mean-value deterministic programming technique is difficult to deal with the multi-period and multi-level uncertain decision-making problem in MWEMPP. Therefore, a multi-stage stochastic programming approach is proposed to solve this problem. This approach first uses the scenario tree to quantitatively describe the bi-level uncertainty of the time and quantity of the CRs, and then build the whole off-line planning alternatives assembles for each possible scenario, at last the optimal planning alternative is selected on-line to flexibly encounter the real scenario in each period. A case is studied to validate the proposed approach. The results confirm that the proposed approach can better hedge against each scenario of the CRs than the traditional mean-value deterministic technique.

  6. Antioxidative defense

    Directory of Open Access Journals (Sweden)

    Stevanović Jelka

    2011-01-01

    Full Text Available Free radicals occur constantly during metabolism and take part in numerous physiological processes, such as: intra-cellular and inter-cellular signalization, gene expression, removal of damaged or senescent cells, and control of the tone of blood vessels. However, there is an increased quantity of free radicals in situations of so-called oxidative stress, when they cause serious damage to cellular membranes (peroxidation of their lipids, damage of membrane proteins, and similar, to interior cellular protein molecules, as well as DNA molecules and carbohydrates. This is precisely why the organism has developed numerous mechanisms for removing free radicals and/or preventing their production. Some of these are enzyme-related and include superoxide-dismutase, catalase, glutathione-peroxidase, and others. Other, non-enzyme mechanisms, imply antioxidative activities of vitamins E and C, provitamin A, coenzyme Q, reduced glutation, and others. Since free radicals can leave the cell that has produced them and become dispersed throughout the body, in addition to antioxidative defense that functions within cellular structures, antioxidant extra-cellular defense has also been developed. This is comprised by: transferrin, lactoferrin, haptoglobin, hemopexin, ceruloplasmin, albumins, extra-cellular isoform SOD, extracellular glutathione-peroxidase, glucose, bilirubin, urates, and many other molecules.

  7. Survey of US Department of Defense Manufacturing Technology Program activities applicable to civilian manufacturing industries. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Azimi, S.A.; Conrad, J.L.; Reed, J.E.

    1985-03-01

    Intent of the survey was to identify and characterize activities potentially applicable to improving energy efficiency and overall productivity in the civilian manufacturing industries. The civilian industries emphasized were the general manufacturing industries (including fabricated metals, glass, machinery, paper, plastic, textile, and transportation equipment manufacturing) and the primary metals industries (including primary aluminum, copper, steel, and zinc production). The principal steps in the survey were to: develop overview taxonomies of the general manufacturing and primary metals industries as well as specific industry taxonomies; identify needs and opportunities for improving process energy efficiency and productivity in the industries included; identify federal programs, capabilities, and special technical expertise that might be relevant to industry's needs and opportunities; contact federal laboratories/facilities, through visits and other forms of inquiry; prepare formatted profiles (descriptions) potentially applicable work efforts; review findings with industry; and compile and evaluate industry responses.

  8. The Effects of Management Initiatives on the Costs and Schedules of Defense Acquisition Programs. Volume 2. Analyses of Ground Combat and Ship Programs

    Science.gov (United States)

    1992-11-01

    negotiate a sales agreement with Turkey, the missiles were ___ 1~2.~~____ _____ __ I handed over to a unit of the New Mexico National Guard, The unit was...87 End Date Sep-89 Sep-06 Sep-06 Qnanthy, N/A N/AN/ Program Status Development-Completed Prduction - -3 yas of data Note: N/A moans not applicable. d...Quantity 12 18 12 Cost $146.5 $337.2 $239.1 3 Total Program Cost $205.9 $443.0 $344.9 Average Unit Cost Prduction $12.2 $18,7 $13,3 Total Pmgrn $17.2 $24.6

  9. Alternate approaches to verifying the structural adequacy of the Defense High Level Waste Shipping Cask

    Energy Technology Data Exchange (ETDEWEB)

    Zimmer, A.; Koploy, M.

    1991-12-01

    In the early 1980s, the US Department of Energy/Defense Programs (DOE/DP) initiated a project to develop a safe and efficient transportation system for defense high level waste (DHLW). A long-standing objective of the DHLW transportation project is to develop a truck cask that represents the leading edge of cask technology as well as one that fully complies with all applicable DOE, Nuclear Regulatory Commission (NRC), and Department of Transportation (DOT) regulations. General Atomics (GA) designed the DHLW Truck Shipping Cask using state-of-the-art analytical techniques verified by model testing performed by Sandia National Laboratories (SNL). The analytical techniques include two approaches, inelastic analysis and elastic analysis. This topical report presents the results of the two analytical approaches and the model testing results. The purpose of this work is to show that there are two viable analytical alternatives to verify the structural adequacy of a Type B package and to obtain an NRC license. It addition, this data will help to support the future acceptance by the NRC of inelastic analysis as a tool in packaging design and licensing.

  10. Syntax-phonology mapping and the Tongan DP

    Directory of Open Access Journals (Sweden)

    Byron Ahn

    2016-04-01

    Full Text Available Tongan, a Polynesian language, is almost entirely head-initial. There are some exceptions to this, including Demonstrative enclitics and the so-called Definitive Accent (Churchward 1953, which appears to be a stress-shift operation, typically in the rightmost word of the DP. One question that arises here is: where does the morphophonological status of being an enclitic come from – particularly in a rather radically head-initial language? By investigating the distributional properties of the Definitive Accent, it will become clear that this is the result of syntactic and phonological structures proceeding without any direct appeal to morphophonological properties. A new formal analysis presented here derives the positions of the Definitive Accent and possible prosodic phrasings, appealing to independently motivated phonological constraints applying to structures with three cross-linguistically supported movement operations. It is shown that achieving this requires neither including morpheme-indexed constraints, nor having lexemes pre-specified with morphophonological properties such as “enclitic” or “prefix”. Finally, Tongan Definitive Accents raise important issues about the immutability of phases. Specifically, it must be that Phonology may access and manipulate previously spelled out material in a way that Syntax cannot, which is in fact exactly what a Minimalist architecture predicts.

  11. Possibilities of utilizing 3DP technology for foundry mould making

    Directory of Open Access Journals (Sweden)

    G. Budzik

    2007-04-01

    Full Text Available Possibilities of application of three-dimensional printing (3DP technology for making casting prototypes are discussed. Three-dimensional printing enables making of foundry moulds for elements of complex shapes. The mould presented in the paper was printed with the use of Z510 Spectrum unit in the Car Technology Sp. z o.o. (Ltd. Co. in Kraków. The basic material for printing foundry moulds is the ZCast 501 powder. This powder is a mixture of traditional molding sand, gypsum and supplementary ingredients. The mould is made in ZCast technology, and it enables casting of zinc, magnesium and aluminum alloys at max. pouring temperature of 1100°C. The paper describes research on the possibility to utilize a standard ZP14 powder for building a rotor blade casting moulds. The research has showed that the ZP14 powder may serve for printing foundry moulds, which should then be subjected to thermo-chemical treatment. Application of the basic ZPrint system powder permits a reduction in mould manufacturing costs.

  12. Creativity in context; the courage in Therivel's GAM/DP.

    Science.gov (United States)

    Gruber, Craig W

    2013-03-01

    The desire to quantify and categorize creativity so that we can easily identify the individual characteristics which serve as its precursors is one which authors have been attempting to successfully complete for some time. In this light, William Therivel's High Creativity Unmasked, discusses how his GAM/DP theory accounts for highly creative people from history as well as a rationale for the rise and fall of creativity in selected cultures throughout history. By examining the latest published work on how Genetic Endowment, Assistances, Misfortunes and Divisions of Power, and how they relate to creativity, Therivel proposes unique rationales for the rises and declines of cultures. This paper examines how creativity and courage work together and in some cases side by side, to explain more fully the role of creativity in culture. This article examines some of Therivel's examples and provides alternate explanations for the phenomena he ascribes to the decline of creativity. In addition, the complexity of both creativity and courage are discussed, both in the current context, and in the next steps for research and theoretical discussion.

  13. A Network Security and Defense Program Based on Ad Hoc%一种基于Ad Hoc的网络安全防御方案

    Institute of Scientific and Technical Information of China (English)

    黄成兵; 陈明东

    2012-01-01

    Analying of Wireless Ad Hoc networks play an important role in society, and its facing a variety of security threats, this paper discusses the advantages and limitations of various network security solutions and technologies for wireless Ad Hoc networks , proposes an in-depth security defense program and explains its implementation process, while points out some of the problems of wireless Ad Hoc networks need to be resolved in the security field.%分析无线Ad Hoc网络在社会中发挥的重要作用及其面临的多种安全威胁,讨论目前各种网络安全解决方案和技术的优点及局限性,提出一种针对无线Ad Hoc网络的纵深安全防御方案并阐述其执行过程,同时指出无线Ad Hoc网络在安全领域急需解决的一些问题.

  14. Physcomitrella patens activates reinforcement of the cell wall, programmed cell death and accumulation of evolutionary conserved defense signals...upon Botrytis cinerea infection

    Science.gov (United States)

    The moss Physcomitrella patens is an evolutionarily basal model system suitable to analyze plant defense responses activated after pathogen assault. Upon infection with the necrotroph Botrytis cinerea (B. cinerea), several defense mechanisms are induced in P. patens, including the fortification of t...

  15. Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein.

    Directory of Open Access Journals (Sweden)

    Zhitao Ru

    Full Text Available A new homozygous humanized transgenic mouse strain, HLA-A2.1(+/+HLA-DP4(+/+ hCD4(+/+mCD4(-/-IAβ(-/-β2m(-/- (HLA-A2/DP4, was obtained by crossing the previously characterized HLA-A2(+/+β2m(-/- (A2 mouse and our previously created HLA-DP4(+/+ hCD4(+/+mCD4(-/-IAβ(-/- (DP4 mouse. We confirmed that the transgenes (HLA-A2, HLA-DP4, hCD4 inherited from the parental A2 and DP4 mice are functional in the HLA-A2/DP4 mice. After immunizing HLA-A2/DP4 mice with a hepatitis B DNA vaccine, hepatitis B virus-specific antibodies, HLA-A2-restricted and HLA-DP4-restricted responses were observed to be similar to those in naturally infected humans. Therefore, the present study demonstrated that HLA-A2/DP4 transgenic mice can faithfully mimic human cellular responses. Furthermore, we reported four new HLA-DP4-restricted epitopes derived from HBsAg that were identified in both vaccinated HLA-A2/DP4 mice and HLA-DP4-positive human individuals. The HLA-A2/DP4 mouse model is a promising preclinical animal model carrying alleles present to more than a quarter of the human population. This model should facilitate the identification of novel HLA-A2- and HLA-DP4-restricted epitopes and vaccine development as well as the characterization of HLA-DP4-restricted responses against infection in humans.

  16. Defense Centers of Excellence for Psychological Health & Traumatic Brain Injury

    Science.gov (United States)

    ... Sign up Search: Defense Centers of Excellence For Psychological Health & Traumatic Brain Injury U.S. Department of Defense ... Reports Program Evaluation DoD/VA PH & TBI Registry Psychological Health About Psychological Health Psychological Health Resources About ...

  17. Korean Defense Industry: Threat or Ally?

    Science.gov (United States)

    1994-02-22

    framework for defense industrial cooperation with Korea . While Senator Dixon eventually dropped his opposition and the Korean Fighter Program is now...US defense firms to transfer technology to Korean firms, the US Government must recognize two realities: first, Korea will develop indigenous...serious Korean competition in the foreseeable future. 8 It does not appear that the Korea defense industry is poised to take away significant market

  18. Composition-dependent structural changes and antitumor activity of ASC-DP/DSPE-PEG nanoparticles.

    Science.gov (United States)

    Higashi, Kenjirou; Mibu, Fusako; Saito, Kengo; Limwikrant, Waree; Yamamoto, Keiji; Moribe, Kunikazu

    2017-03-01

    Ascorbyl 2,6-dipalmitate (ASC-DP) and distearoyl phosphatidylethanolamine polyethylene glycol 2000 (DSPE-PEG) formed stable nanoparticles at a molar ratio of less than or equal to 2:1 after dispersing the solvent-evaporated film in water. The mean particle sizes measured by dynamic light scattering were within the range of ca. 100-160nm. Composition-dependent changes of the ASC-DP and DSPE-PEG molecular states within the film were analyzed by wide-angle X-ray diffraction and infrared (IR) and solid-state nuclear magnetic resonance (NMR) spectroscopy. Transmission electron microscopy (TEM) of nanoparticles revealed that ASC-DP/DSPE-PEG changed from a micelle to a disk and tubular structure as the molar ratio increased. Quantitative solution-state (1)H NMR measurements elucidated the structure of nanoparticle in water; the core could be composed of ASC-DP and hydrophobic acyl chains of DSPE, whereas the hydrophilic PEG chains of DSPE-PEG on the surface form the hydration shell to stabilize the nanoparticle dispersion in water. Cytotoxicity of ASC-DP against cancer cell lines was observed by using ASC-DP/DSPE-PEG nanoparticles, and no cytotoxicity against normal cells was found. Thus, the ASC-DP/DSPE-PEG formulation, with tumor cell specific cytotoxicity, can be applicable for cancer monotherapy or in combination with other anticancer drugs. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

    DEFF Research Database (Denmark)

    Helin, K; Wu, C L; Fattaey, A R

    1993-01-01

    homolog of DP-1. Human DP-1 and E2F-1 associate both in vivo and in vitro, and this interaction leads to enhanced binding to E2F DNA-binding sites. The association of E2F-1 and DP-1 leads to cooperative activation of an E2F-responsive promoter. Finally, we demonstrate that E2F-1 and DP-1 association...

  20. Defense Headquarters: Improved Data Needed to Better Identify Streamlining and Cost Savings Opportunities by Function

    Science.gov (United States)

    2016-06-01

    approaches from the commercial sector to the department’s six core business processes— management of human resources , healthcare, financial flow... human resource programs for nonappropriated funds, and centrally managed information technology functions. Most of the personnel involved in these...Defense Contract Management Agency • Defense Finance and Accounting Service • Defense Health Agency • Defense Human Resource Activity • Defense

  1. DP8-12糊精的应用研究%Study on application of DP8-12 dextrin

    Institute of Scientific and Technical Information of China (English)

    朱秋享; 李志达; 张汉辉; 赖韦萍; 林龙珍

    2002-01-01

    实验测定了自制DP8-12糊精粉剂的吸湿性和溶解度,结果显示,该产品吸湿性不大而有较好的溶解度.用3种糊精作为壁材对维生素C、茶多酚和酒进行包埋试验,结果表明,DP8-12糊精具有比普通糊精和麦芽糊精更好的包埋性能.

  2. Global distribution of equatorial plasma bubbles in the premidnight sector during solar maximum as observed by KOMPSAT-1 and Defense Meteorological Satellite Program F15

    Science.gov (United States)

    Park, Jaeheung; Min, Kyoung Wook; Kim, Vitaly P.; Kil, Hyosub; Lee, Jae-Jin; Kim, Hee-Jun; Lee, Ensang; Lee, Dae Young

    2005-07-01

    We investigated the global distribution of equatorial plasma bubbles (EPBs) using in situ plasma density measurements from Korea Multipurpose Satellite-1 (KOMPSAT-1) and Defense Meteorological Satellite Program (DMSP) F15 during the solar maximum period from June 2000 to August 2001. The results were generally consistent with those of previous studies. EPBs were observed at all longitudes around the magnetic dip equator in the equinoctial seasons with the peak occurrence in the American-Atlantic-African regions. During the June solstice, EPBs occurred predominantly in the African sector, with enhancements in the magnetic north in the Indian and west Pacific regions, but were totally suppressed in the American-Atlantic sector. During the December solstice, EPBs occurred frequently in the American-Atlantic sector but were suppressed in the other longitude sectors, especially in the Pacific sector. The EPB occurrence probability was seen to be correlated with the observed topside plasma density and the model prereversal upward drift speed of ambient plasmas (Fejer et al., 1999), with their respective dominance dependent on the seasons. However, the peak EPB occurrence in the American-Atlantic sector during the December solstice was displaced somewhat from the region of peak density and upward drift, probably due to a strong solar terminator influence on the flux tube-integrated E region Pedersen conductivity and due to anomaly morphology. The peak EPB occurrence in the African sector during the June solstice is consistent only with the high ambient density in that region, for there was no coincidence with the maximum vertical drift or the minimum E region Pedersen conductivity.

  3. Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion.

    Science.gov (United States)

    Cerna, Joel; Cerecedo, Doris; Ortega, Arturo; García-Sierra, Francisco; Centeno, Federico; Garrido, Efrain; Mornet, Dominique; Cisneros, Bulmaro

    2006-10-01

    Dystrophin Dp71 is the main product of the Duchenne muscular dystrophy gene in the brain; however, its function is unknown. To study the role of Dp71 in neuronal cells, we previously generated by antisense treatment PC12 neuronal cell clones with decreased Dp71 expression (antisense-Dp71 cells). PC12 cells express two different splicing isoforms of Dp71, a cytoplasmic variant called Dp71f and a nuclear isoform called Dp71d. We previously reported that antisense-Dp71 cells display deficient adhesion to substrate and reduced immunostaining of beta1-integrin in the cell area contacting the substrate. In this study, we isolated additional antisense-Dp71 clones to analyze in detail the potential involvement of Dp71f isoform with the beta1-integrin adhesion system of PC12 cells. Immunofluorescence analyses as well as immunoprecipitation assays demonstrated that the PC12 cell beta1-integrin adhesion complex is composed of beta1-integrin, talin, paxillin, alpha-actinin, FAK and actin. In addition, our results showed that Dp71f associates with most of the beta1-integrin complex components (beta1-integrin, FAK, alpha-actinin, talin and actin). In the antisense-Dp71 cells, the deficiency of Dp71 provokes a significant reduction of the beta1-integrin adhesion complex and, consequently, the deficient adhesion of these cells to laminin. In vitro binding experiments confirmed the interaction of Dp71f with FAK and beta1-integrin. Our data indicate that Dp71f is a structural component of the beta1-integrin adhesion complex of PC12 cells that modulates PC12 cell adhesion by conferring proper complex assembly and/or maintenance.

  4. Defense Acquisition Performance Assessment Report

    Science.gov (United States)

    2006-01-01

    Incorporated – “Changing the System” HeLLeR , TRiCiA A., Deputy Director of Congressional Support, Technical and Analytical Support, USAF A-Team...Interview Recorder” HeLLieR, RiCHARD, Director of Air Force Programs, United Technologies – “Joint Stars System” HeRMAN , DR. ROBeRT, Member, Defense

  5. Tensile and Fatigue Properties of Single and Multiple Dissimilar Welded Joints of DP980 and HSLA

    Science.gov (United States)

    Cui, Q. L.; Parkes, D.; Westerbaan, D.; Nayak, S. S.; Zhou, Y.; Saha, D. C.; Liu, D.; Goodwin, F.; Bhole, S.; Chen, D. L.

    2017-01-01

    The present study focused on single and multiple dissimilar joints between DP980 and high-strength low-alloy (HSLA) galvanized steels. The tensile properties of the dissimilar joint between the strong DP980 and the relatively soft HSLA reflected only the properties of HSLA with plastic deformation, and final fracture took place entirely in HSLA. The fatigue properties of the dissimilar joints were more intriguing, with the strong DP980 outperforming at high stress amplitude and the ductile HSLA outperforming at low stress amplitude. For different load amplitudes, fatigue failure occurred in different materials and at different locations. The fatigue strength of DP980 was more negatively impaired by weld defects than that of HSLA.

  6. Recent development of double pulse laser induced breakdown spectroscopy (DP-LIBS setup

    Directory of Open Access Journals (Sweden)

    David Prochazka

    2010-12-01

    Full Text Available Single pulse (SP LIBS setup was modified to DP setup to achievemore accurate analytical sensitivity and spatial resolution. Allparameters, like interpulse delay, acquisition delay or energy ofablation and excitation laser pulses were optimized.

  7. Defense Healthcare Information Assurance Program

    Science.gov (United States)

    2001-06-01

    34* Computerized Patient Record Institute ( CPRI ) annual conference in Washington D.C. "* American Telemedicine Association (ATA) annual conference...TATRC) 3 May-00 Phoenix, AZ ATA Conference ATI I Awd + 4 Pittsburgh, PA IPR #1 ATI, SEI, ADL, 6 LMES, HOST, KRM, (TATRC) Jul-00 Washington, DC CPRI

  8. SOAP3-dp: fast, accurate and sensitive GPU-based short read aligner.

    Directory of Open Access Journals (Sweden)

    Ruibang Luo

    Full Text Available To tackle the exponentially increasing throughput of Next-Generation Sequencing (NGS, most of the existing short-read aligners can be configured to favor speed in trade of accuracy and sensitivity. SOAP3-dp, through leveraging the computational power of both CPU and GPU with optimized algorithms, delivers high speed and sensitivity simultaneously. Compared with widely adopted aligners including BWA, Bowtie2, SeqAlto, CUSHAW2, GEM and GPU-based aligners BarraCUDA and CUSHAW, SOAP3-dp was found to be two to tens of times faster, while maintaining the highest sensitivity and lowest false discovery rate (FDR on Illumina reads with different lengths. Transcending its predecessor SOAP3, which does not allow gapped alignment, SOAP3-dp by default tolerates alignment similarity as low as 60%. Real data evaluation using human genome demonstrates SOAP3-dp's power to enable more authentic variants and longer Indels to be discovered. Fosmid sequencing shows a 9.1% FDR on newly discovered deletions. SOAP3-dp natively supports BAM file format and provides the same scoring scheme as BWA, which enables it to be integrated into existing analysis pipelines. SOAP3-dp has been deployed on Amazon-EC2, NIH-Biowulf and Tianhe-1A.

  9. DP-FPGA: An FPGA Architecture Optimized for Datapaths

    Directory of Open Access Journals (Sweden)

    Don Cherepacha

    1996-01-01

    Full Text Available This paper presents a new Field-Programmable Gate Array (FPGA architecture which reduces the density gap between FPGAs and Mask-Programmed Gate Arrays (MPGAs for datapath oriented circuits. This is primarily achieved by operating on data as a number of identically programmed four-bit slices. The interconnection network incorporates distinct sets of resources for routing control and data signals. These features reduce circuit area by sharing programming bits among four-bit slices, reducing the total number of storage cells required.

  10. Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

    Science.gov (United States)

    Wu, Xiaozhe; Li, Zhan; Li, Xiaolu; Tian, Yaomei; Fan, Yingzi; Yu, Chaoheng; Zhou, Bailing; Liu, Yi; Xiang, Rong; Yang, Li

    2017-01-01

    Antibiotic-resistant bacteria present a great threat to public health. In this study, the synergistic effects of antimicrobial peptides (AMPs) and antibiotics on several multidrug-resistant bacterial strains were studied, and their synergistic effects on azithromycin (AZT)-resistance genes were analyzed to determine the relationships between antimicrobial resistance and these synergistic effects. A checkerboard method was used to evaluate the synergistic effects of AMPs (DP7 and CLS001) and several antibiotics (gentamicin, vancomycin [VAN], AZT, and amoxicillin) on clinical bacterial strains (Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and Escherichia coli). The AZT-resistance genes (ermA, ermB, ermC, mefA, and msrA) were identified in the resistant strains using quantitative polymerase chain reaction. For all the clinical isolates tested that were resistant to different antibiotics, DP7 had high antimicrobial activity (≤32 mg/L). When DP7 was combined with VAN or AZT, the effect was most frequently synergistic. When we studied the resistance genes of the AZT-resistant isolates, the synergistic effect of DP7–AZT occurred most frequently in highly resistant strains or strains carrying more than two AZT-resistance genes. A transmission electron microscopic analysis of the S. aureus strain synergistically affected by DP7–AZT showed no noteworthy morphological changes, suggesting that a molecular-level mechanism plays an important role in the synergistic action of DP7–AZT. AMP DP7 plus the antibiotic AZT or VAN is more effective, especially against highly antibiotic-resistant strains. PMID:28356719

  11. The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons.

    Science.gov (United States)

    Towers, Emily; Gilley, Jonathan; Randall, Rebecca; Hughes, Rosie; Kristiansen, Mark; Ham, Jonathan

    2009-05-01

    The death of sympathetic neurons after nerve growth factor (NGF) withdrawal requires de novo gene expression. Dp5 was one of the first NGF withdrawal-induced genes to be identified and it encodes a proapoptotic BH3-only member of the Bcl-2 family. To study how dp5 transcription is regulated by NGF withdrawal we cloned the regulatory regions of the rat dp5 gene and constructed a series of dp5-luciferase reporter plasmids. In microinjection experiments with sympathetic neurons we found that three regions of dp5 contribute to its induction after NGF withdrawal: the promoter, a conserved region in the single intron, and sequences in the 3' untranslated region of the dp5 mRNA. A construct containing all three regions is efficiently activated by NGF withdrawal and, like the endogenous dp5, its induction requires mixed-lineage kinase (MLK) and c-Jun N-terminal kinase (JNK) activity. JNKs phosphorylate the AP-1 transcription factor c-Jun, and thereby increase its activity. We identified a conserved ATF site in the dp5 promoter that binds c-Jun and ATF2, which is critical for dp5 promoter induction after NGF withdrawal. These results suggest that part of the mechanism by which the MLK-JNK-c-Jun pathway promotes neuronal apoptosis is by activating the transcription of the dp5 gene.

  12. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease.

    Science.gov (United States)

    Mack, Douglas G; Falta, Michael T; McKee, Amy S; Martin, Allison K; Simonian, Philip L; Crawford, Frances; Gordon, Terry; Mercer, Robert R; Hoover, Mark D; Marrack, Philippa; Kappler, John W; Tuder, Rubin M; Fontenot, Andrew P

    2014-06-10

    Susceptibility to chronic beryllium disease (CBD) is linked to certain HLA-DP molecules, including HLA-DP2. To elucidate the molecular basis of this association, we exposed mice transgenic (Tg) for HLA-DP2 to beryllium oxide (BeO) via oropharyngeal aspiration. As opposed to WT mice, BeO-exposed HLA-DP2 Tg mice developed mononuclear infiltrates in a peribronchovascular distribution that were composed of CD4(+) T cells and included regulatory T (Treg) cells. Beryllium-responsive, HLA-DP2-restricted CD4(+) T cells expressing IFN-γ and IL-2 were present in BeO-exposed HLA-DP2 Tg mice and not in WT mice. Using Be-loaded HLA-DP2-peptide tetramers, we identified Be-specific CD4(+) T cells in the mouse lung that recognize identical ligands as CD4(+) T cells derived from the human lung. Importantly, a subset of HLA-DP2 tetramer-binding CD4(+) T cells expressed forkhead box P3, consistent with the expansion of antigen-specific Treg cells. Depletion of Treg cells in BeO-exposed HLA-DP2 Tg mice exacerbated lung inflammation and enhanced granuloma formation. These findings document, for the first time to our knowledge, the development of a Be-specific adaptive immune response in mice expressing HLA-DP2 and the ability of Treg cells to modulate the beryllium-induced granulomatous immune response.

  13. A variant of the dynamic programming algorithm for unit commitment of combined heat and power systems

    DEFF Research Database (Denmark)

    Rong, Aiying; Hakonen, Henri; Lahdelma, Risto

    2008-01-01

    in the system, the number of periods over the planning horizon and the time for solving a single-period economic dispatch problem. We have compared the DP-RSC1 algorithm with realistic power plants against the unit decommitment algorithm and the traditional priority listing method. The results show that the DP...... introduce in this paper the DP-RSC1 algorithm, which is a variant of the dynamic programming (DP) algorithm based on linear relaxation of the ON/OFF states of the units and sequential commitment of units one by one. The time complexity of DP-RSC1 is proportional to the number of generating units...

  14. The Defense Science Board 1999 Summer Study Task Force on 21st Century Defense Technology Strategies. Volume 1

    Science.gov (United States)

    2016-06-07

    Study Task Force On 21ST Century Defense Technology Strategies Volume 1 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR...3. Defense Technology Strategy and Management PART 4. Strategic Agility PART 5. Analysis and Quantitative Results iii PREFACE The Defense Science...Board (DSB) 1999 Summer Study Task Force on 21st Century Defense Technology Strategies continues a series of studies that have examined key challenges

  15. Performance investigations of novel dual-material gate(DMG) MOSFET with dielectric pockets(DP)

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Dual-material gate MOSFET with dielectric pockets (DMGDP MOSFET) is proposed to eliminate the potential weakness of the DP MOSFET for CMOS scaling toward the 32 nm gate length and beyond. The short-channel effects (SCE) can be effectively suppressed by the insulator near the source/drain regions. And the suppression capability can be even better than the DP MOSFET due to the drain bias absorbed by the screen gate. The speed performance and electronic characteristics of the DMGDP MOSFET are comprehensively studied. Compared to the experimental data from Jurczak et al., the DMGDP PMOSFET exhibits good subthreshold characteristics and the on-state current is almost the twice that of the DP PMOSFET. The intrinsic delay of the NMOS reaches 21% greater than the DP MOSFET for 32 nm node. The higher fT of 390 GHz is achieved, which is a 32% enhancement in comparison with the DP MOSFET when the gate length is 50 nm. Finally, the design guideline and the optimal regions of the DMGDP MOSFET are discussed.

  16. Performance investigations of novel dual-material gate (DMG)MOSFET with dielectric pockets(DP)

    Institute of Scientific and Technical Information of China (English)

    LUAN SuZhen; LIU HongXia; JIA RenXu

    2009-01-01

    Dual-material gate MOSFET with dielectric pockets(DMGDP MOSFET)is proposed to eliminate the potential weakness of the DP MOSFET for CMOS scaling toward the 32 nm gate length and beyond.The short-channel effects(SCE)can be effectively suppressed by the insulator near the source/drain regions.And the suppression capability can be even better than the DP MOSFET due to the drain bias absorbed by the screen gate.The speed performance and electronic characteristics of the DMGDP MOSFET are comprehensively studied.Compared to the experimental data from Jurczak et al.,the DMGDP PMOSFET exhibits good subthreshold characteristics and the on-state current is almost the twice that of the DP PMOSFET.The intrinsic delay of the NMOS reaches 21% greater than the DP MOSFET for 32 nm node.The higher fT of 390 GHz is achieved,which is a 32% enhancement in comparison with the DP MOSFET when the gate length is 50 nm.Finally,the design guideline and the opUmal regions of the DMGDP MOSFET are discussed.

  17. Low Cycle Fatigue Behaviour of DP Steels: Micromechanical Modelling vs. Validation

    Directory of Open Access Journals (Sweden)

    Ghazal Moeini

    2017-07-01

    Full Text Available This study aims to simulate the stabilised stress-strain hysteresis loop of dual phase (DP steel using micromechanical modelling. For this purpose, the investigation was conducted both experimentally and numerically. In the experimental part, the microstructure characterisation, monotonic tensile tests and low cycle fatigue tests were performed. In the numerical part, the representative volume element (RVE was employed to study the effect of the DP steel microstructure of the low cycle fatigue behavior of DP steel. A dislocation-density based model was utilised to identify the tensile behavior of ferrite and martensite. Then, by establishing a correlation between the monotonic and cyclic behavior of ferrite and martensite phases, the cyclic deformation properties of single phases were estimated. Accordingly, Chaboche kinematic hardening parameters were identified from the predicted cyclic curve of individual phases in DP steel. Finally, the predicted hysteresis loop from low cycle fatigue modelling was in very good agreement with the experimental one. The stabilised hysteresis loop of DP steel can be successfully predicted using the developed approach.

  18. Utrophins compensate for Dp71 absence in mdx3cv in adhered platelets.

    Science.gov (United States)

    Cerecedo, Doris; Mondragón, Ricardo; Candelario, Aurora; García-Sierra, Francisco; Mornet, Dominique; Rendón, Alvaro; Martínez-Rojas, Dalila

    2008-01-01

    Platelet adhesion is a critical step due to its hemostatic role in stopping bleeding after vascular damage. Short dystrophins are the most abundant dmd gene products in nonmuscle tissues, and in association with cytoskeleton proteins contribute to their intrinsic function; while utrophins are dystrophin-homologous related family proteins with structural and functional similarities. We previously demonstrated the presence of Dp71 isoforms, utrophins, and various dystrophin-associated proteins and their participation in cytoskeleton re-organization, filopodia and lamellipodia extension, and in centralizing cytoplasmic granules during the adhesion process of human platelets. To evaluate the morphologic changes and actin-based structures of mdx(3cv) platelets during the adhesion process, we compared the topographic distribution of Dp71d/Dp71Delta110(m) and dystrophin-associated protein in adhered platelets from dystrophic mdx(3cv) mouse. By confocal microscopy, we showed that absence of Dp71 isoforms in platelets from this animal model disrupted dystrophin-associated protein expression and distribution without modifying the platelet morphology displayed during the glass-adhesion process. By immunoprecipitation assays, we proved that up-regulated utrophins were associated with dystrophin-associated proteins to conform the dystrophin-associated protein complex corresponding to utrophins, which might compensate for Dp71 absence in mdx(3cv) platelets.

  19. Cytotoxicity of DP-bioglass paste used for treatment of dentin hypersensitivity.

    Science.gov (United States)

    Kuo, Tien-Chun; Lee, Bor-Shiunn; Kang, Shu-Han; Lin, Feng-Huei; Lin, Chun-Pin

    2007-04-01

    DP-bioglass mixed with 30% phosphoric acid has been suggested to treat dentin hypersensitivity because the material is able to produce homogeneous occlusion of exposed dentinal tubules and is able to provide a sealing depth of up to 60 microm. The purpose of this study was to investigate the relative cytotoxic effect of the DP-bioglass paste, intermediate restorative material (IRM; DeTrey, Dentsply, Germany), and commercial desensitizing agent (Abmindent; Abmin Technologies Ltd, Turku, Finland) on human dental pulp cells by using a transwell insert model and a dentin-disc model. Cell viability was measured by means of a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results of this study indicated that cell viability for the DP-bioglass paste did not differ significantly from those of the IRM or Abmindent in the transwell insert model. In addition, MTT results of DP-bioglass paste were similar to the control group in the dentin-disc model. The results indicated that DP-bioglass paste was a highly biocompatible material and could potentially serve as an effective material for treatment of dentin hypersensitivity.

  20. 1-FFT amino acids involved in high DP inulin accumulation in Viguiera discolor

    Directory of Open Access Journals (Sweden)

    Emerik eDe Sadeleer

    2015-08-01

    Full Text Available Fructans are important vacuolar reserve carbohydrates with drought, cold, ROS and general abiotic stress mediating properties. They occur in 15% of all flowering plants and are believed to display health benefits as a prebiotic and dietary fiber. Fructans are synthesized by specific fruc- tosyltransferases and classified based on the linkage type between fructosyl units. Inulins, one of these fructan types with β(2-1 linkages, are elongated by fructan:fructan 1-fructosyltransferases (1-FFT using a fructosyl unit from a donor inulin to elongate the acceptor inulin molecule. The sequence identity of the 1-FFT of Viguiera discolor (Vd and Helianthus tuberosus (Ht is 91% although these enzymes produce distinct fructans. The Vd 1-FFT produces high degree of poly- merization (DP inulins by preferring the elongation of long chain inulins, in contrast to the Ht 1-FFT which prefers small molecules (DP3 or 4 as acceptor. Since higher DP inulins have in- teresting properties for industrial, food and medical applications, we report here on the influence of two amino acids on the high DP inulin production capacity of the Vd 1-FFT. Introducing the M19F and H308T mutations in the active site of the Vd 1-FFT greatly reduces its capacity to pro- duce high DP inulin molecules. Both amino acids can be considered important to this capacity, although the double mutation had a much higher impact than the single mutations.

  1. A DP based scheme for real-time reconfiguration of solar cell arrays exposed to dynamic changing inhomogeneous illuminations

    DEFF Research Database (Denmark)

    Shi, Liping; Brehm, Robert

    2016-01-01

    The overall energy conversion efficiency of solar cell arrays is highly effected by partial shading effects. Especially for solar panel arrays installed in environments which are exposed to inhomogeneous dynamic changing illuminations such as on roof tops of electrical vehicles the overall system...... efficiency is drastically reduced. Dynamic real-time reconfiguration of the solar panel array can reduce effects on the output efficiency due to partial shading. This results in a maximized power output of the panel array when exposed to dynamic changing illuminations. The optimal array configuration...... with respect to shading patterns can be stated as a combinatorial optimization problem and this paper proposes a dynamic programming (DP) based algorithm which finds the optimal feasible solution to reconfigure the solar panel array for maximum efficiency in real-time with linear time complexity. It is shown...

  2. Research on Modeling of Allocation of Air Defense Troops Based on Programming Method%基于规划方法的防空兵兵力区分问题建模

    Institute of Scientific and Technical Information of China (English)

    蒋里强; 王桂花; 王纯; 高建军

    2014-01-01

    The allocation of air defense troops is an important step of troops disposition,a correct scheme about combat grouping and combat formation disposition could be worked out only after the allocation of air defense troops has been done. This paper is devoted to study allocation problem of troops during the process of coordination operation between ground -to -air missile forces and antiaircraft artillery forces within combat zone of air defense troops. Taking the mathematic expectation of destroying enemy air raid weapons as objective function,a nonlinear programming model is built and the optimal scheme of troops allocation is found to help commander make a policy by use of Lingo software.%防空兵兵力区分是防空兵兵力部署的一个重要环节,在进行正确的兵力区分基础上,才能进行正确的战斗编组和战斗队型配置。研究了防空兵作战地幅内地空导弹兵与高射炮兵协同作战时的兵力区分问题,以消灭敌空兵器的数学期望为目标函数,用规划方法建立了该问题的数学模型,用Lingo软件求出了兵力区分的最佳方案。

  3. DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity.

    Science.gov (United States)

    Yeghiazaryan, Marine; Rutkowska-Wlodarczyk, Izabela; Konopka, Anna; Wilczyński, Grzegorz M; Melikyan, Armenuhi; Korkotian, Eduard; Kaczmarek, Leszek; Figiel, Izabela

    2014-01-01

    DP-b99 is a membrane-activated chelator of zinc and calcium ions, recently proposed as a therapeutic agent. Matrix metalloproteinases (MMPs) are zinc-dependent extracellularly operating proteases that might contribute to synaptic plasticity, learning and memory under physiological conditions. In excessive amounts these enzymes contribute to a number of neuronal pathologies ranging from the stroke to neurodegeneration and epileptogenesis. In the present study, we report that DP-b99 delays onset and severity of PTZ-induced seizures in mice, as well as displays neuroprotective effect on kainate excitotoxicity in hippocampal organotypic slices and furthermore blocks morphological reorganization of the dendritic spines evoked by a major neuronal MMP, MMP-9. Taken together, our findings suggest that DP-b99 may inhibit neuronal plasticity driven by MMPs, in particular MMP-9, and thus may be considered as a therapeutic agent under conditions of aberrant plasticity, such as those subserving epileptogenesis.

  4. Lung inflammation and thymic atrophy after bleomycin are controlled by the prostaglandin D2 receptor DP1.

    Science.gov (United States)

    van den Brule, Sybille; Huaux, François; Uwambayinema, Francine; Ibouraadaten, Saloua; Yakoub, Yousof; Palmai-Pallag, Mihaly; Trottein, François; Renauld, Jean-Christophe; Lison, Dominique

    2014-01-01

    Acute lung injury (ALI) can be accompanied by secondary systemic manifestations. In a model of ALI induced by bleomycin (bleo), we examined the response of D prostanoid receptor 1 (DP1)-deficient mice (DP1(-/-)) to better understand these processes. DP1 deficiency aggravated the toxicity of bleo as indicated by enhanced body weight loss, mortality, and lung inflammation including bronchoalveolar permeability and neutrophilia. Thymic atrophy was also observed after bleo and was strongly exacerbated in DP1(-/-) mice. This resulted from the enhanced depletion of immature T lymphocytes in the thymus of DP1(-/-) mice, a phenomenon usually related to increased glucocorticoid release in blood. Serum corticosterone was more elevated in DP1(-/-) mice after bleo than in wild-type (wt) mice. Thymocytes of DP1(-/-) mice were not more sensitive to dexamethasone in vitro, and systemic delivery of dexamethasone or peritoneal inflammation after LPS induced a similar thymic atrophy in wt and DP1(-/-) mice, indicating that pulmonary DP1 was critical to the control of thymic atrophy after bleo. DP1(-/-) mice showed increased lung and/or blood mediators involved in neutrophil recruitment and/or glucocorticoid production/thymic atrophy (osteopontin, leukemia inhibitory factor, and keratinocyte-derived chemokine) after bleo. Finally, local pulmonary DP1 activation or inhibition in wt mice abrogated or amplified thymic atrophy after bleo, respectively. Altogether, our data reveal that ALI can perturb the systemic T-cell pool by inducing thymic atrophy and that both pathological processes are controlled by the pulmonary DP1 receptor. This new pathway represents a potential therapeutic target in ALI.

  5. Application of Mechanical System in DP3 Drillship%轮机系统在DP3钻井船上的应用

    Institute of Scientific and Technical Information of China (English)

    朱百祥; 吴国顺; 向小斌; 郭金

    2015-01-01

    随着国内海工业的发展,越来越多的海工平台和工程船舶配备动力定位系统,本文阐述了动力定位系统各等级的要求和冗余度,并结合现有的一艘DP3深水钻井船的设计经验,详细描述了轮机系统在该类船舶上的设计和应用。%With the development of the offshore industry in the country, more and more offshore platforms and working vessels are equipped with the dynamic positioning system. The article explains the requirement of different DP classes and the exact redundancy. Combining the design experience of a recent DP3 deepwater drillship, it describes the design and application of the mechanical systems on this kind of vessels.

  6. Recognizing plant defense priming

    NARCIS (Netherlands)

    Martinez-Medina, A.; Flors, V.; Heil, M.; Mauch-Mani, B.; Pieterse, C.M.J.; Pozo, M.J.; Ton, J.; Van Dam, N.M.; Conrath, U.

    2016-01-01

    Defense priming conditions diverse plant species for the superinduction of defense, often resulting in enhanced pest and disease resistance and abiotic stress tolerance. Here, we propose a guideline that might assist the plant research community in a consistent assessment of defense priming in plant

  7. Relationship between Material Properties and Local Formability of DP980 Steels

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Kyoo Sil; Soulami, Ayoub; Li, Dongsheng; Sun, Xin; Khaleel, Mohammad A.; Xu, Le; Barlat, Frederic

    2012-04-24

    A noticeable degree of inconsistent forming behaviors has been observed for the 1st generation advanced high strength steels (AHSS) in production, and they appear to be associated with the inherent microstructural-level inhomogeneities for various AHSS. This indicates that the basic material property requirements and screening methods currently used for the mild steels and high strength low alloys (HSLA) are no longer sufficient for qualifying today’s AHSS. In order to establish more relevant material acceptance criteria for AHSS, the fundamental understandings on key mechanical properties and microstructural features influencing the local formability of AHSS need to be developed. For this purpose, in this study, DP980 was selected as model steels and eight different types of DP980 sheet steels were acquired from various steel suppliers. Various experiments were then performed on the eight different DP980 steels such as chemical composition analysis, static tensile test, hole expansion test, channel forming test. Scanning electron microscope (SEM) pictures of the DP980 steels were also obtained, and image processing tools were then adopted to those SEM pictures in order to quantify their various microstructural features. The results show that all DP980 steels show large discrepancy in their performance and that the tensile properties and hole expansion properties of these steels do not correlate with their local formability. According to the results up to date, it is not possible to correlate the microstructural features alone to the macroscopically measured deformation behaviors. In addition to image analysis, other experiments (i.e., nano-indentation test) are also planned to quantify the individual phase properties of the various DP steels.

  8. Rechargeable Mg battery cathode TiS3 with d-p orbital hybridized electronic structures

    Science.gov (United States)

    Taniguchi, Kouji; Gu, Yunpeng; Katsura, Yukari; Yoshino, Takafumi; Takagi, Hidenori

    2016-01-01

    Rechargeable performance is realized in Mg batteries using a TiS3 cathode without the nanometer-scale downsizing of electrode particles. The specific capacity is about 80 mAh/g for the first 50 cycles at room temperature. This observed specific capacity is comparable to that of the prototype cathode for Mg batteries. First-principles calculation indicates that TiS3 is a semiconductor with d-p orbital hybridized electronic structures around the Fermi level. The reversible electrode performance is likely assisted by the delocalized electronic distribution over metal-ligand units through d-p orbital hybridization.

  9. Strategies for Dealing with the Defense Budget

    Science.gov (United States)

    1983-08-17

    UNCLASSIFIED ItCUWIfV CUAWICATIOH O^ T>"» *»C« C.»lt— Omm gnt REPORT D0ajM6NTATI0N PAGE READ rNSTRUCTIO.NS OSFOPC COMWLETTNG FORM DSSW BOA ...documentation. \\ STRATEGIES FOR DEALING WITH THE DEFENSE BUDGET for Defense Systems Management College DSSW BOA No. MDA 903-82-G-0047 BOOZ ALLEN...Frisch, Franz A. and Acker, David D., "Financing Defense System Programs," Concepts (J. Def. Sys. Acq. Mgmt.), Vol. 4, No. 4, Autumn 1981, pp. 7

  10. Dynamic programming on a tree for ultrasound elastography

    Science.gov (United States)

    Shams, Roozbeh; Boily, Mathieu; Martineau, Paul A.; Rivaz, Hassan

    2016-04-01

    Ultrasound Elastography is an emerging imaging technique that allows estimation of the mechanical characteristics of tissue. Two issues that need to be addressed before widespread use of elastography in clinical environments are real time constraints and deteriorating effects of signal decorrelation between pre- and post-compression images. Previous work has used Dynamic Programming (DP) to estimate tissue deformation. However, in case of large signal decorrelation, DP can fail. In this paper we, have proposed a novel solution to this problem by solving DP on a tree instead of a single Radio-Frequency line. Formulation of DP on a tree allows exploiting significantly more information, and as such, is more robust and accurate. Our results on phantom and in-vivo human data show that DP on tree significantly outperforms traditional DP in ultrasound elastography.

  11. Modelling dynamic programming problems by generalized d-graphs

    CERN Document Server

    Kátai, Zoltán

    2010-01-01

    In this paper we introduce the concept of generalized d-graph (admitting cycles) as special dependency-graphs for modelling dynamic programming (DP) problems. We describe the d-graph versions of three famous single-source shortest algorithms (The algorithm based on the topological order of the vertices, Dijkstra algorithm and Bellman-Ford algorithm), which can be viewed as general DP strategies in the case of three different class of optimization problems. The new modelling method also makes possible to classify DP problems and the corresponding DP strategies in term of graph theory.

  12. Defense Enterprise Accounting and Management System-Increment 1 (DEAMS Inc 1)

    Science.gov (United States)

    2016-03-01

    2016 Major Automated Information System Annual Report Defense Enterprise Accounting and Management System-Increment 1 (DEAMS Inc 1) Defense...Phone: 937-257-2714 Fax: DSN Phone: 787-2714 DSN Fax: Date Assigned: August 17, 2015 Program Information Program Name Defense Enterprise Accounting ...UNCLASSIFIED 4 Program Description The Defense Enterprise Accounting and Management System (DEAMS) is a key part of the United States Air Force (USAF

  13. A Variational P1 -DP0 Diffusion Theory for Planar Geometry

    Energy Technology Data Exchange (ETDEWEB)

    Brantley, P S

    2002-04-06

    A variational analysis is used to derive a mixed P{sub 1}DP{sub 0} (spherical harmonics-double spherical harmonics) angular approximation to the time-independent monoenergetic neutron transport equation with linearly anisotropic scattering in one-dimensional planar geometry. This mixed approximation contains a space-dependent weight factor {alpha}(x) that controls the local angular approximation used: {alpha}(x) = 1 yields the standard P{sub 1} (diffusion) approximation, {alpha}(x) = 0 gives the standard DP{sub 0} approximation, and 0 < {alpha}(x) < 1 produces a mixed approximation. The diffusion equation obtained differs from the standard P{sub 1} diffusion equation only in the definition of the diffusion coefficient. The variational analysis shows that both the scalar flux and the current are continuous at material interfaces regardless of the value of {alpha}(x). Standard Marshak boundary conditions are also obtained via the variational analysis. In this paper, they examine the use of this mixed angular approximation to more accurately treat material interfaces and vacuum boundaries. Numerical results from a mixed-oxide fuel test problem are presented to demonstrate that significant improvements in accuracy can be obtained using this method. For this test problem, the mixed P{sub 1}-DP{sub 0} angular approximation with {alpha} = 0.25 is found to be more robust than the standard DP{sub 0} approximation ({alpha} = 0) for treating the material interfaces and vacuum boundaries.

  14. Dp-brane Tension from Tachyons and B-field in Vacuum String Field Theory

    CERN Document Server

    Matlock, P; Viswanathan, K S; Yang, Y

    2002-01-01

    We consider tachyonic string-field fluctuations about a Dp-brane background in the geometrical (CFT) formulation of vacuum string field theory. We then extend this analysis to the case of a background B-field. We find that the standard results for D-brane tension are reproduced in both cases.

  15. y-Deformed BPS Dp-branes On a Surface In a Calabi-Yau Threefold

    CERN Document Server

    Ospina, J F

    2000-01-01

    Using y-deformed algebraic geometric techniques the y-deformed Mukay vector of RR-charges of the y-deformed BPS Dp-branes localized on a surface in a Calabi-Yau threefold. The formulas that are obtained here are generalizations of the formulas of the fourth section of the preprint hep-th/0007243 .

  16. Engineering Task Plan for Hepa Filter Differential Pressure (DP) Fan Interlock Upgrades

    Energy Technology Data Exchange (ETDEWEB)

    SIMONS, S.R.

    2000-05-19

    This document provides a plan for installation of Differential Pressure (DP) fan interlocks on the primary ventilation systems in selected Tank Farm facilities. This plan contains the engineering tasks required for installation and is summarized by the Acceptance for Beneficial Use list. Individuals responsible for each task are identified and scheduled accordingly.

  17. 76 FR 52663 - Notice of Intent To Award Affordable Care Act Funding, DP-09-001

    Science.gov (United States)

    2011-08-23

    ... 4002 of the Patient Protection and Affordable Care Act (Pub. L. 111-148.). DATES: The effective date..., 2010, the President signed into law the Patient Protection and Affordable Care Act (ACA). ACA is... Care Act Funding, DP-09-001 AGENCY: Centers for Disease Control and Prevention (CDC), Department...

  18. The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking

    DEFF Research Database (Denmark)

    Schratl, Petra; Royer, Julia F; Kostenis, Evi

    2007-01-01

    Prostaglandin (PG) D2 is a major mast cell product that acts via two receptors, the D-type prostanoid (DP) and the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) receptors. Whereas CRTH2 mediates the chemotaxis of eosinophils, basophils, and Th2 lymphocytes, the role...

  19. Year 2000 compliance concerns with the ISA Thermoluminescent Dosimetry Data Processing (TL-DP) software system

    Energy Technology Data Exchange (ETDEWEB)

    Saviz, K.

    1998-05-26

    The year 2000 is rapidly approaching, and there is a good chance that computer systems that utilize two digit year dates will experience problems in retrieval of date information. The ISA Thermoluminescent Dosimetry Data Processing (TL-DP) software and computer system has been reviewed for Year 2000 compliance issues.

  20. Cloning, expression and cellular localization of Daphnia pulex senescence-associated protein, DpSAP.

    Science.gov (United States)

    Liu, Ajing; Kong, Ling; Zhang, Mingqing; Wu, Donglei; Wang, Danli; Zhao, Yunlong

    2014-01-25

    Daphnia (water fleas) are small crustaceans that undergo an unusual switch from asexual to sexual reproduction that is dependent on environmental conditions. In this study, a senescence-associated protein (SAP) from the common freshwater species Daphnia pulex was cloned using primers based on homologous sequences and rapid amplification of cDNA ends (RACE). Real-time PCR was employed to quantify the expression of D. pulex SAP (DpSAP) in individual organisms. The role of DpSAP in the reproductive transformation was further investigated in both parthenogenetic and sexual females by using digoxin-labeled SAP RNA probes and RNA whole-mount in situ hybridization. DpSAP was more highly expressed in sexual females, indicating a role in growth and reproduction. Cellular localization studies using RNA whole-mount in situ hybridization showed specific expression in the second tentacle joints. These expression patterns suggest an important role for DpSAP in the reproductive transformation of D. pulex. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Spin(p+1, p+1) covariant Dp-brane bound states

    NARCIS (Netherlands)

    Sundell, P

    2001-01-01

    We construct Spin(p + 1, p + 1) covariant Dp-brane bound states by using the fact that the potentials in the RR sector of toroidically compactified type Ii supergravity transform as a chiral spinor of the T duality group. As an application, we show the invariance of the zero-force condition for a pr

  2. High phase noise tolerant pilot-tone-aided DP-QPSK optical communication systems

    DEFF Research Database (Denmark)

    Zhang, Xu; Pang, Xiaodan; Deng, Lei

    2012-01-01

    In this paper we experimentally demonstrate a novel, high phase-noise tolerant, optical dual polarization (DP) quadrature phase-shift keying (QPSK) communication system based on pilot-tone-aided phase noise cancellation (PNC) algorithm. Vertical cavity surface emitting lasers (VCSELs...

  3. HLA-DP antigens in patients with chronic autoimmune thrombocytopenia (AITP)

    DEFF Research Database (Denmark)

    Mueller-Eckhardt, G; Pawelec, G; Haas, R;

    1989-01-01

    AITP, a disease with well-defined autoimmune character, has been previously studied for a possible HLA association. However, no such association with antigens of the A, B, C or DR loci was found. As this does not exclude a possible association with HLA-DP antigens, we have investigated 36 patients...

  4. HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6

    DEFF Research Database (Denmark)

    Ødum, Niels; Milman, N; Jakobsen, B K

    1991-01-01

    The distribution of HLA class II (DR, DQ, and DP) antigens was studied in 41 patients with symptomatic sarcoidosis (SA) and ethnically matched healthy controls. HLA-DR, -DQw1 and -DQw3 typings were performed with alloantisera in the conventional microcytotoxic test, whereas -DP typings were done...

  5. The molecular origin of the thiamin diphosphate-induced spectral bands of ThDP-dependent enzymes

    NARCIS (Netherlands)

    Kovina, M.V.; Kok, A.; Sevostyanova, I.A.; Khailova, L.S.; Belkina, N.V.; Kochetov, G.A.

    2004-01-01

    New and previously published data on a variety of ThDP-dependent enzymes such as baker's yeast transketolase, yeast pyruvate decarboxylase and pyruvate dehydrogenase from pigeon breast muscle, bovine heart, bovine kidney, Neisseria meningitidis and E. coli show their spectral sensitivity to ThDP bin

  6. Microstructure and dynamic tensile behavior of DP600 dual phase steel joint by laser welding

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Danyang, E-mail: dongdanyang@mail.neu.edu.cn [College of Science, Northeastern University, No. 11, Lane 3, WenHua Road, HePing District, Shenyang 110819 (China); Liu, Yang, E-mail: liuyang@mail.neu.edu.cn [Key Laboratory for Anisotropy and Texture of Materials, Ministry of Education, Northeastern University, Shenyang 110819 (China); Yang, Yuling, E-mail: yulingyang@mail.neu.edu.cn [College of Science, Northeastern University, No. 11, Lane 3, WenHua Road, HePing District, Shenyang 110819 (China); Li, Jinfeng, E-mail: lijinfengboda@163.com [College of Science, Northeastern University, No. 11, Lane 3, WenHua Road, HePing District, Shenyang 110819 (China); Ma, Min, E-mail: sharon6789@163.com [College of Science, Northeastern University, No. 11, Lane 3, WenHua Road, HePing District, Shenyang 110819 (China); Jiang, Tao, E-mail: tao.jiang906@yahoo.com [College of Science, Northeastern University, No. 11, Lane 3, WenHua Road, HePing District, Shenyang 110819 (China)

    2014-01-31

    Dual phase (DP) steels have been widely used in the automotive industry to reduce vehicle weight and improve car safety. In such applications welding and joining have to be involved, which would lead to a localized change of the microstructure and property, and create potential safety and reliable issues under dynamic loading. The aim of the present study is to examine the rate-dependent mechanical properties, deformation and fracture behavior of DP600 steel and its welded joint (WJ) produced by Nd:YAG laser welding over a wide range of strain rates (0.001–1133 s{sup −1}). Laser welding results in not only significant microhardness increase in the fusion zone (FZ) and inner heat-affected zone (HAZ), but also the formation of a softened zone in the outer HAZ. The yield strength (YS) of the DP600 steel increases and the ultimate tensile strength (UTS) remains almost unchanged, but the ductility decreases after welding. The DP600 base metal (BM) and WJ are of positive strain rate sensitivity and show similar stress–strain response at all studied strain rates. The enhanced ductility at strain rates ranging from 1 to 100 s{sup −1} is attributed to the retardation of the propagation of plastic strain localization due to the positive strain rate sensitivity and the thermal softening caused by deformation induced adiabatic temperature rise during dynamic tensile deformation. The tensile failure occurs in the inner HAZ of the joint and the distance of failure location from the weld centerline decreases with increasing strain rate. The mechanism for the changing failure location can be related to the different strain rate dependence of the plastic deformation behavior of the microstructures in various regions across the joint. The DP600 WJ absorbs more energy over the whole measured strain rates than that of the BM due to the higher strength at the same strain when the deformation only up to 10% is considered.

  7. Clinical evaluation of the xDP output compression strategy for cochlear implants.

    Science.gov (United States)

    Bozorg-Grayeli, Alexis; Guevara, Nicolas; Bebear, Jean-Pierre; Ardoint, Marine; Saaï, Sonia; Hoen, Michel; Gnansia, Dan; Romanet, Philippe; Lavieille, Jean-Pierre

    2016-09-01

    Technological advances in the domain of digital signal processing adapted to cochlear implants (CI) are partially responsible for the ever-improving outcomes observed with this neural prosthesis. The goal of the present study was to evaluate audiometric outcomes with a new signal processing strategy implemented in Oticon Medical-Neurelec cochlear implant systems, the xDP strategy. The core of this approach is a preset-based back-end output compression system, modulating a multi-channel transfer function depending on the intensity and information content of input sounds. Twenty adult CI patients, matched for age and CI experience, were included in this study. Pure-tone thresholds and vocal audiometry scores were measured with their former signal processing strategy and with xDP. Speech perception was assessed using dissyllabic words presented in quiet, at different intensity levels: 40, 55, 70, and 85 dB SPL, and in a cocktail party noise at a signal-to-noise ratio of +10 dB. Results with the xDP strategy showed, as awaited, no major modification of pure-tone thresholds. A global increase of speech perception scores was observed after a 1-month habituation period, with significant improvements for speech perception in quiet for moderate (55 dB SPL), loud speech sounds (85 dB SPL), and speech-in-noise comprehension. Subjective signal quality assessment showed a preference for Crystalis(xDP) over the former strategy. These results allow the quantification of improvements provided by the xDP signal processing strategy.

  8. Alginate Oligosaccharide DP5 Exhibits Antitumor Effects in Osteosarcoma Patients following Surgery

    Directory of Open Access Journals (Sweden)

    Jiayu Chen

    2017-09-01

    Full Text Available Osteosarcoma is a malignant musculoskeletal tumor that has high-rate morbidity and mortality worldwide. Alginate oligosaccharide (AOS, a natural product, has antitumor activities and may have therapeutic effects in osteosarcoma, the molecular mechanisms of which remain unclear. AOS was prepared from alginate sodium using alginate lyase. The fractions of AOS were further isolated by size-exclusion chromatography and verified by electrospray ionization mass spectrometry (ESI-MS. Osteosarcoma patients were enrolled in the study and assigned into two groups: AOS (AG, oral administration of 10-mg AOS daily and control groups (CG, placebo. Preoperative and postoperative clinical data were investigated and analyzed. Four different degrees of polymerizations (DPs were isolated and denominated as DP2, DP3, DP4, and DP5. Among these polymers, only DP5 showed antitumor functions on osteosarcoma cells. Before surgery and the outcome of primary end point after surgery, no significant differences were observed for clinical data and tumor size between the AG and CG groups (P > 0.05. After 2-year therapy, the mean tumor volume was 214.6 ± 145.7 c.c. in AG and 467.2 ± 225.3 c.c in CG (P < 0.01. The rate of local recurrence was 44.9 and 68.7% in AG and CG, respectively (P < 0.01. AOS treatment resulted in the increase in serum levels of SOD, GSH, HDL-C, and reduction in the levels of interleukin-1 (IL-1 beta and IL-6; the ratios of AST/ALT; and triglycerides, total cholesterol (TC, low-density lipoprotein cholesterol LDL-C, and malondialdehyde (MDA (P < 0.05. AOS reduces osteosarcoma progression, which is associated with improvement in antioxidant and anti-inflammatory capacities of patients, and may be used as a potential drug for osteosarcoma therapy.

  9. Design and Implementation of RS232/PROFIBUS-DP Intelligent Slave%PROFIBUS-DP/RS232智能从站的设计与实现

    Institute of Scientific and Technical Information of China (English)

    王征; 张婕; 张云生

    2007-01-01

    实现RS232设备和PROFIBUS-DP总线的通讯对于工业控制有着重要的意义.本文介绍了PROFIBUS-DP/RS232智能从站的设计要点,阐述了智能从站在硬件和软件上的实现方法.实践表明:智能从站对主站和RS232接口设备具有数据传输功能,为系统开放互连和现场分布式控制打下基础.

  10. The Application of Random Sampling System Based on VBA Programming in The Graduation Thesis Defense%基于VBA编程的随机抽题系统在毕业答辩中应用

    Institute of Scientific and Technical Information of China (English)

    侯伟; 吴锦杨; 娄晓明

    2016-01-01

    毕业答辩是大学生本科教育阶段整个学习过程中最后一道实践教学环节,本毕业答辩抽题系统结合VBA编程和微信公众号互联网技术,改变了传统毕业答辩环节中的纸质化抽签及抽题的形式,减少纸张及碳粉的消耗。本抽题系统可适用于毕业答辩、课堂教学互动、晚会现场抽奖、教学知识竞赛、面试随机抽题等需要随机抽签或抽题的场合。该系统能够使每一位在场用户通过投影仪屏幕同时看到随机所抽题目,相比传统纸质抽题更公平公正。%[Abstract]Graduation thesis defense is the last practice teaching link in the whole learning process of undergraduate education phase.This question system of graduation thesis defense combined with VBA programming and WeChat public Internet technology.It can not only change the draw and question form with paper in the traditional graduation reply link,but also reduce the consumption of paper and toner.This question system can be applied to many occasions.Such as graduation thesis defenses,interactive classroom-teaching,the lucky draw on the party,knowledge competition of teaching,random question on the interview and so on.The system allows each user to see the randomly drawing question through the projector screen. Compared with the traditional paper question,this system is more fair and square.

  11. Moving Target Defense

    CERN Document Server

    Jajodia, Sushil; Swarup, Vipin; Wang, Cliff; Wang, X Sean

    2011-01-01

    Moving Target Defense: Creating Asymmetric Uncertainty for Cyber Threats was developed by a group of leading researchers. It describes the fundamental challenges facing the research community and identifies new promising solution paths. Moving Target Defense which is motivated by the asymmetric costs borne by cyber defenders takes an advantage afforded to attackers and reverses it to advantage defenders. Moving Target Defense is enabled by technical trends in recent years, including virtualization and workload migration on commodity systems, widespread and redundant network connectivity, instr

  12. Dynamic defense workshop :

    Energy Technology Data Exchange (ETDEWEB)

    Crosby, Sean Michael; Doak, Justin E.; Haas, Jason Juedes.; Helinski, Ryan; Lamb, Christopher C.

    2013-02-01

    On September 5th and 6th, 2012, the Dynamic Defense Workshop: From Research to Practice brought together researchers from academia, industry, and Sandia with the goals of increasing collaboration between Sandia National Laboratories and external organizations, de ning and un- derstanding dynamic, or moving target, defense concepts and directions, and gaining a greater understanding of the state of the art for dynamic defense. Through the workshop, we broadened and re ned our de nition and understanding, identi ed new approaches to inherent challenges, and de ned principles of dynamic defense. Half of the workshop was devoted to presentations of current state-of-the-art work. Presentation topics included areas such as the failure of current defenses, threats, techniques, goals of dynamic defense, theory, foundations of dynamic defense, future directions and open research questions related to dynamic defense. The remainder of the workshop was discussion, which was broken down into sessions on de ning challenges, applications to host or mobile environments, applications to enterprise network environments, exploring research and operational taxonomies, and determining how to apply scienti c rigor to and investigating the eld of dynamic defense.

  13. Developing an Assessment, Monitoring, and Evaluation Framework for U.S. Department of Defense Security Cooperation

    Science.gov (United States)

    2016-09-01

    48 3.3. MoDA AME Process...evaluation MACOM major command MCC Millennium Challenge Corporation MoDA Ministry of Defense Advisors MfR Managing for Results MOE measure of effectiveness...Minis- try of Defense Advisors ( MoDA ) program, and the Defense Education Enhancement Program (DEEP).8 The DIB AME process, though con- 7 See Perry et

  14. FY2002 Progress Summary Program Plan, Statement of Work and Deliverables for Development of High Average Power Diode-Pumped Solid State Lasers, and Complementary Technologies, for Applications in Energy and Defense

    Energy Technology Data Exchange (ETDEWEB)

    Bayramian, A; Bibeau, C; Beach, R; Behrendt, B; Ebbers, C; Latkowski, J; Meier, W; Payne, S; Perkins, J; Schaffers, K; Skulina, K; Ditmire, T; Kelly, J; Waxer, L; Rudi, P; Randles, M; Witter, D; Meissner, H; Merissner, O

    2001-12-13

    The High Average Power Laser Program (HAPL) is a multi-institutional, coordinated effort to develop a high-energy, repetitively pulsed laser system for Inertial Fusion Energy and other DOE and DOD applications. This program is building a laser-fusion energy base to complement the laser-fusion science developed by DOE Defense programs over the past 25 years. The primary institutions responsible for overseeing and coordinating the research activities are the Naval Research Laboratory (NRL) and LLNL. The current LLNL proposal is a companion proposal to that submitted by NRL, for which the driver development element is focused on the krypton fluoride excimer laser option. Aside from the driver development aspect, the NRL and LLNL companion proposals pursue complementary activities with the associated rep-rated laser technologies relating to target fabrication, target injection, final optics, fusion chamber, materials and power plant economics. This report requests continued funding in FY02 to support LLNL in its program to build a 1kW, 100J, diode-pumped, crystalline laser. In addition, research in high gain laser target design, fusion chamber issues and survivability of the final optic element will be pursued. These technologies are crucial to the feasibility of inertial fusion energy power plants and also have relevance in rep-rated stewardship experiments.

  15. Survey of Laboratories and Implementation of the Federal Defense Laboratory Diversification Program. Annex A. Department of the Army Domestic Technology Transfer

    Science.gov (United States)

    1993-11-01

    benefits provided by ARL’s substantial investment in marketing tools and displays which have been developed for use by the DTI" program as well as other ARL...conference. Other marketing tools range from tri-fold single page hand outs, up to 20 to 30 page full color brochures. The ARL DTT program is...this year several new marketing tools have been developed: a) An ARL DTr handout which provides a brief description of ARL, the DTT program technology

  16. Serious Games: Defense Advanced Research Projects Agency: An Interview with Innovation Information Office Program Manager CAPT Russell Shilling, PhD.

    Science.gov (United States)

    2012-04-01

    Dr. Shilling received his Doctor of Philosophy in Experimental Psychology (Auditory Psychophysics/Neuroscience) from the University of North Carolina at Greensboro in 1992 and his Bachelor of Arts in Psychology at Wake Forest University in 1985. In 1993 he graduated with top honors from Aerospace Experimental Psychologist training-Naval Flight Surgeon Class 93002. In 1996, he served as an Assistant/Associate Professor at the U.S. Air Force Academy in the Department of Behavioral Sciences and Leadership. In 2000, he arrived at the Naval Postgraduate School as an Associate Professor in the Operations Research and Systems Engineering Departments and became Technical Director for Immersive Technologies in the Modeling, Virtual Environments, and Simulation Institute. His military decorations include the Defense Superior Service Medal, Meritorious Service Medal (three awards), the Navy Commendation Medal, and the Navy Achievement Medal. He is also the recipient of the American Hospital Association's 2009 Executive Award for Excellence.

  17. Department of Energy plan for recovery and utilization of nuclear byproducts from defense wastes. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    1983-08-01

    Nuclear wastes from the defense production cycle contain many uniquely useful, intrinsically valuable, and strategically important materials. These materials have a wide range of known and potential applications in food technology, agriculture, energy, public health, medicine, industrial technology, and national security. Furthermore, their removal from the nuclear waste stream can facilitate waste management and yield economic, safety, and environmental advantages in the management and disposal of the residual nuclear wastes that have no redemptive value. This document is the program plan for implementing the recovery and beneficial use of these valuable materials. An Executive Summary of this document, DOE/DP-0013, Vol. 1, January 1983, is available. Program policy, goals and strategy are stated in Section 2. Implementation tasks, schedule and funding are detailed in Section 3. The remaining five sections and the appendixes provide necessary background information to support these two sections. Section 4 reviews some of the unique properties of the individual byproduct materials and describes both demonstrated and potential applications. The amounts of byproduct materials that are available now for research and demonstration purposes, and the amounts that could be recovered in the future for expanded applications are detailed in Section 5. Section 6 describes the effects byproduct recovery and utilization have on the management and final disposal of nuclear wastes. The institutional issues that affect the recovery, processing and utilization of nuclear byproducts are discussed in Section 7. Finally, Section 8 presents a generalized mathematical process by which applications can be evaluated and prioritized (rank-ordered) to provide planning data for program management.

  18. Unfolding Green Defense

    DEFF Research Database (Denmark)

    Larsen, Kristian Knus

    2015-01-01

    consumption in military operations, defense expenditure, energy security, and global climate change. The report then proceeds to introduce the NATO Green Defence Framework before exploring specific current uses of green technologies and green strategies for defense. The report concludes that a number...

  19. Avian host defense peptides

    NARCIS (Netherlands)

    Cuperus, Tryntsje; Coorens, M.; van Dijk, A.; Haagsman, H.P.

    2013-01-01

    Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense

  20. Defense Mechanisms: A Bibliography.

    Science.gov (United States)

    Pedrini, D. T.; Pedrini, Bonnie C.

    This bibliography includes studies of defense mechanisms, in general, and studies of multiple mechanisms. Defense mechanisms, briefly and simply defined, are the unconscious ego defendants against unpleasure, threat, or anxiety. Sigmund Freud deserves the clinical credit for studying many mechanisms and introducing them in professional literature.…

  1. Computational study on the carboligation reaction of acetohidroxyacid synthase: new approach on the role of the HEThDP- intermediate.

    Science.gov (United States)

    Jaña, Gonzalo; Jiménez, Verónica; Villà-Freixa, Jordi; Prat-Resina, Xavier; Delgado, Eduardo; Alderete, Joel

    2010-05-15

    Acetohydroxyacid synthase (AHAS) is a thiamin diphosphate dependent enzyme that catalyses the decarboxylation of pyruvate to yield the hydroxyethyl-thiamin diphosphate (ThDP) anion/enamine intermediate (HEThDP(-)). This intermediate reacts with a second ketoacid to form acetolactate or acetohydroxybutyrate as products. Whereas the mechanism involved in the formation of HEThDP(-) from pyruvate is well understood, the role of the enzyme in controlling the carboligation reaction of HEThDP(-) has not been determined yet. In this work, molecular dynamics (MD) simulations were employed to identify the aminoacids involved in the carboligation stage. These MD studies were carried out over the catalytic subunit of yeast AHAS containing the reaction intermediate (HEThDP(-)) and a second pyruvate molecule. Our results suggest that additional acid-base ionizable groups are not required to promote the catalytic cycle, in contrast with earlier proposals. This finding leads us to postulate that the formation of acetolactate relies on the acid-base properties of the HEThDP(-) intermediate itself. PM3 semiempirical calculations were employed to obtain the energy profile of the proposed mechanism on a reduced model of the active site. These calculations confirm the role of HEThDP(-) intermediate as the ionizable group that promotes the carboligation and product formation steps of the catalytic cycle. Proteins 2010. (c) 2010 Wiley-Liss, Inc.

  2. Hydrologic resources management program, FY 1998 progress report

    Energy Technology Data Exchange (ETDEWEB)

    Benedict, F.C.; Criss, R.E.; Davisson, M.L.; Eaton, G.F.; Hudson, G.B.; Kenneally, J.M.; Rose, T.P.; Smith, D.

    1999-07-26

    This report presents the results from FY 1998 technical studies conducted by Lawrence Livermore National Laboratory (LLNL) as part of the Hydrology and Radionuclide Migration Program (HRMP) and Underground Test Area (UGTA) project. The HRMP is sponsored by Defense Programs (DP) of the U.S. Department of Energy, Nevada Operations Office (DOE/NV), and supports DP operations at the Nevada Test Site (NTS) through studies of radiochemistry and resource management related to the defense programs mission. Other participating organizations include the Los Alamos National Laboratory (LANL), the United States Geological Survey (USGS), the Desert Research Institute (DRI) of the University of Nevada, the United States Environmental Protection Agency (EPA), and Bechtel-Nevada (BN). The UGTA project is an Environmental Management (EM) activity of DOE/NV that supports a Federal Facilities Agreement and Consent Order between the Department of Energy, the Department of Defense, and the State of Nevada. UGTA's primary function is to address the legacy release of hazardous constituents at the Nevada Test Site, the Tonopah Test Range, and off-Nevada Test Site underground nuclear testing areas. Participating contractors include LLNL (Earth and Environmental Sciences Directorate, Analytical and Nuclear Chemistry Division), LANL, DRI, USGS, BN, HSI-GeoTrans, and IT Corporation. The FY 1998 HRMP and UGTA annual progress report follows the organization and contents of our FY 1997 report (Smith et al., 1998), and includes our results from CY 1997-1998 technical studies of radionuclide migration and isotope hydrology at the Nevada Test Site. During FY 1998, LLNL continued its efforts under the HRMP to pursue a technical agenda relevant to the science-based stockpile stewardship program at DOE/NV. Support to UGTA in FY 1998 included efforts to quantitatively define the radionuclide source term residual from underground nuclear weapons testing and the derivative solution, or hydrologic

  3. Analysis of Defense Products Contract Trends, 1990-2014

    Science.gov (United States)

    2015-04-30

    Analysis of Defense Products Contract Trends , 1990–2014 Andrew Hunter—is a senior fellow in the International Security Program and director of the Defense...a decade, the Defense-Industrial Initiatives Group at the Center for Strategic and International Studies (CSIS) has analyzed and reported on trends ...countervailing trend of divestments, including Northrop Grumman’s divestment of its shipbuilding business into Huntington Ingalls Industries. As

  4. Modeling grain orientation of DP600 steel by Nd:YAG laser

    Directory of Open Access Journals (Sweden)

    Liu Shibo

    2016-01-01

    Full Text Available A FE-CA (Finite Element-Cellular Automaton model is built to simulate the microstructure evaluation during laser welding of DP600 high strength steel. A moving conical heat source is performed in ABAQUS to achieve temperature field during welding. A linear interpolation method is used to transfer node temperature of ABAQUS to cell temperature of Cellular Automaton. With the consideration of temperature and solute concentration, the solidification of DP600 after weld is simulated. The established FE-CA model can simulate 2D equiaxed and column dendrite grain growth. The competitive growth between different dendrite arms is presented. The weld microstructure simulation result shows good agreement with experiment results.

  5. Nucleus geometry and mechanical properties of resistance spot welded coated–uncoated DP automotive steels

    Indian Academy of Sciences (India)

    Ibrahim Sevim; Fatih Hayat; Mustafa Kemal Kulekci

    2013-11-01

    In this study, mechanical properties of resistance spot welding of DP450 and DP600, galvanized and ungalvanized automotive sheets have been investigated. The specimens have been joined by resistance spot welding at different weld currents and times. Welded specimens have been examined for their mechanical, macrostructure and microstructure properties. Depending on the weld current and time, effects of zinc coating on tensile properties, microhardness values as well as microstructure nugget geometry and nucleus size ratio have been investigated. X-ray diffraction analysis has been used to investigate the phase that formed at the joint interface. Result of the experiment show that nugget diameter, indentation depth and tensile load-bearing capacity are affected by weld parameters. Coating prevents full joining at low parameters. Microhardness increased in heat-affected zone and weld metal.

  6. Architecture, Voltage, and Components for a Turboelectric Distributed Propulsion Electric Grid (AVC-TeDP)

    Science.gov (United States)

    Gemin, Paul; Kupiszewski, Tom; Radun, Arthur; Pan, Yan; Lai, Rixin; Zhang, Di; Wang, Ruxi; Wu, Xinhui; Jiang, Yan; Galioto, Steve; Haran, Kiruba; Premerlani, William; Bray, Jim; Caiafa, Antonio

    2015-01-01

    The purpose of this effort was to advance the selection, characterization, and modeling of a propulsion electric grid for a Turboelectric Distributed Propulsion (TeDP) system for transport aircraft. The TeDP aircraft would constitute a miniature electric grid with 50 MW or more of total power, two or more generators, redundant transmission lines, and multiple electric motors driving propulsion fans. The study proposed power system architectures, investigated electromechanical and solid state circuit breakers, estimated the impact of the system voltage on system mass, and recommended DC bus voltage range. The study assumed an all cryogenic power system. Detailed assumptions within the study include hybrid circuit breakers, a two cryogen system, and supercritical cyrogens. A dynamic model was developed to investigate control and parameter selection.

  7. Correlations between Nanoindentation Hardness and Macroscopic Mechanical Properties in DP980 Steels

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Mark D.; Choi, Kyoo Sil; Sun, Xin; Matlock, David K.; Packard, Corrine; Xu, Le; Barlat, Frederic

    2014-03-01

    Multiphase advanced high strength steels (AHSS) are being increasingly used in the automotive industry due to their low cost, good availability and excellent combination of strength and ductility. There is a keen interest from the automotive and steel industry for more fundamental understandings on the key microstructure features influencing the macroscopic properties, i.e., tensile properties, hole-expansion ratio and localized formability of AHSS. In this study, the micro- and macro-level properties for eight commercial DP980 steels are first characterized and quantified with various experimental methods. Correlations between macroscopic-level properties and relationships between various micro- and macro- properties for these steels are then established based on the experimental measurements. It is found that, despite their differences in their chemistry, processing parameters and sheet thickness, the eight DP980 steels do have common microstructural level properties governing their specific macroscopic properties in terms of strength, elongation and hole expansion performance.

  8. Inhibition of allostimulated HLA-DQ and DP-specific T cells by staphylococcal enterotoxin A

    DEFF Research Database (Denmark)

    Masewicz, S; Ledbetter, J A; Martin, P

    1993-01-01

    to play an important role in superantigen binding to class II molecules, but the functional implications of these differences remain largely unknown. In the present investigation, we studied the effects of SEA, SEB, and TSST on allostimulation of HLA-DR-, DQ-, and DP-allospecific T-cell clones. To avoid...... direct stimulation of T-cell responses by the superantigens, SEA and/or SEB nonresponsive T-cell clones were selected. We show that SEA strongly inhibited DQ- and DP-specific T-cell responses. In contrast, SEB and TSST had only weak inhibitory effects. DR-specific T-cell responses were unaffected or only...... weakly inhibited by the superantigens tested. The inhibition appeared not to be due to induction of cytotoxicity or suppression of either T cells or EBV-LCLs by SEA. In conclusion, the bacterial superantigen SEA can block alloantigen-specific stimulation of T clones in vitro. These results suggest...

  9. Investigation of Droplet Deposition for Suspensions Usable for Thermoplastic 3D Printing (T3DP)

    Science.gov (United States)

    Scheithauer, Uwe; Johne, Robert; Weingarten, Steven; Schwarzer, Eric; Richter, Hans-Jürgen; Moritz, Tassilo; Michaelis, Alexander

    2017-09-01

    Thermoplastic 3D printing (T3DP) is an additive manufacturing (AM) technology, which can be used for the production of dense single- and especially multi-material components. This becomes possible because of the combination of the precise deposition of small droplets of molten thermoplastic suspensions containing ceramic or metal particles, and a curing mechanism caused on cool down increasing the viscosity. In this paper, the droplet formation behavior of zirconia suspensions for T3DP (82 and 84 wt.%) was investigated. The droplet fusion factor (dff) is introduced to calculate the necessary distance between two droplets to form filament-like structures by fusion of adjacent droplets. Filament-like structures with a smooth surface and a nearly homogeneous cross section were manufactured for both suspensions with a dff of 44% or higher.

  10. Characteristics of Welding Crack Defects and Failure Mode in Resistance Spot Welding of DP780 Steel

    Institute of Scientific and Technical Information of China (English)

    Xiao-pei WANG; Yong-qiang ZHANG; Jian-bin JU; Jian-qiang ZHANG; Jian-wei YANG

    2016-01-01

    The mechanical properties of welded joints in resistance spot welding of DP780 steel were tested,and three dif-ferent types of welding cracks in welded joints were investigated by optical microscopy,scanning electron microscopy and electron back-scattered diffraction.Finally,the failure mode of the welded joints in shear tensile test was dis-cussed.It is found the shear tensile strength of welded joints can be greatly improved by adding preheating current or tempering current.The surface crack in welded joint is intergranular fracture,while the inner crack in welded joint is transgranular fracture,and the surface crack on the edge of the electrode imprint can be improved by adding prehea-ting current or tempering current.The traditional failure mode criterion advised by American Welding Society is no longer suitable for DP780 spot welds and the critical nugget size suggested by Pouranvari is overestimated.

  11. Defense Industry Clusters in Turkey

    Directory of Open Access Journals (Sweden)

    Kadir Alpaslan Demir

    2016-06-01

    Full Text Available All countries strive for a capable national defense supported by a strong national defense industry. Supporting national defense with imported defense systems has many limitations and risks because the terms of arms trade agreements between countries may easily be influenced by the political climate of the signatories. As a result, establishing an independent national defense requires a strong national defense industry. Furthermore, exporting defense systems may be an important source of national income. National defense industries mostly consist of large-scale defense firms that have the resources required for big defense contracts. However, small to medium enterprises (SMEs do not have the necessary resources, therefore they are at a disadvantage. To overcome this handicap and be part of the business, defense industry clusters mostly consisting of SMEs are being established. Provided that there is good national planning and support in this area, defense clusters consisting of SMEs may play a significant role in industry. SMEs have a chance to offer specialized services, special or customized products when needed. As a result, large defense firms subcontract certain portions of defense projects to SMEs. Since 2010, Turkey has shown signs of continuous improvement in defense industry clustering. In parallel with these developments, this study discusses the importance of clustering in the defense industry, briefly presents the state of the Turkish defense industry as highlighted by national statistics, and presents the current status of defense clusters in Turkey. The novelty of this article consists in its assessment of Turkish defense clusters.

  12. Spin-dependent np {yields}pn amplitude estimated from dp{yields}ppn

    Energy Technology Data Exchange (ETDEWEB)

    Glagolev, V.V.; Khvastunov, M.S.; Ladygina, N.B.; Piskunov, N.M. [Joint Institute for Nuclear Research, 141980 Dubna (Russian Federation); Hlavacova, J. [Technical University, Park Komenskeho 2, SK-04200, Kosice (Slovakia); Martinska, G.; Urban, J. [University of P.J. Safarik, Jesenna 5, SK-04154 Kosice (Slovakia); Musinsky, J. [Joint Institute for Nuclear Research, 141980 Dubna (Russian Federation); University of P.J. Safarik, Jesenna 5, SK-04154 Kosice (Slovakia); Pastircak, B. [Institute of Experimental Physics SAS, Watsonova 47, SK-04353, Kosice (Slovakia); Siemiarczuk, T. [Institute of Nuclear Studies,ul. Hoza 69, Warsaw, PL-00 681 (Poland)

    2002-12-01

    An estimation of the spin-dependent part of the np{yields}pn charge exchange amplitude was made on the basis of dp{yields}(pp)n data, taken at 1.67 GeV/c per nucleon in a full solid-angle arrangement. The np{yields}pn amplitude turned out to be entirely spin-dependent. This result shows new possibilities for experiments using polarized deuteron beams and polarized proton targets. (orig.)

  13. Some special features of a rotating-moving Dp-brane

    Science.gov (United States)

    Safarzadeh-Maleki, Farzin

    2016-07-01

    Using the boundary string field theory (BSFT) techniques we study the boundary state and partition function for a dynamical (rotating-moving) Dp-brane coupled to the electromagnetic and tachyonic background fields in superstring theory. By making use of the created partition function, the super BSFT action with a tachyonic field and Dirac-Born-Infeld-type action will be constructed. By analyzing the obtained action interesting features will be revealed.

  14. Polarization observables in dp backward elastic scattering at high and intermediate energies

    CERN Document Server

    Tanifuji, M; Iseri, Y

    1998-01-01

    The tensor analyzing power $T_{20}$ and the polarization transfer coefficients $\\kappa_0 (= 3/2 K_y^y)$ and $K_{xz}^y$ are investigated for dp backward elastic scattering by the invariant-amplitude method. Discrepancies between the conventional calculations and the experimental data on $T_{20}$ and imaginary parts in the amplitudes. The quantity $K_{xz}^y$ is shown to be useful in criticizing nuclear force assumptions.

  15. Quantifying the effects of tempering on individual phase properties of DP980 steel with nanoindentation

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, G.; Zhang, F.; Ruimi, A.; Field, D. P.; Sun, X.

    2016-06-01

    We conduct a series of thermal and mechanical testing on a commercial dual phase (DP) 980 steel in order to quantify the effects of tempering on its individual phase properties. Tempering treatment is conducted at 250 °C and 400 °C for 60 minutes each. Ferrite and martensite grains are distinguished using electron backscatter diffraction (EBSD) and scanning probe microscopy (SPM), and the martensite volume fractions (MVF) are determined based on the image quality (IQ) map. Multi-scale indentation tests combined with a newly developed inverse method are used to obtain the individual phase flow properties in each tempered DP980 sample. The results show that, i) tempering significantly reduces martensite yield strength, while it only slightly reduces the ferrite yield strength; ii) tempering temperature has a more significant influence on the work hardening exponent of ferrite than that of martensite; iii) the elastic modulus of martensite is consistently higher than that of ferrite. As a validation, a simple rule of mixtures is used to verify the above-predicted individual phase flow stresses with the experimentally obtained overall true stress vs. true strain curves. The methodology and the corresponding results shown in this study can help guide the selection of tempering parameters in optimizing the mechanical properties of DP steels for their intended applications.

  16. Density-functional study on the equilibria in the ThDP activation.

    Science.gov (United States)

    Delgado, Eduardo J; Alderete, Joel B; Jaña, Gonzalo A

    2011-11-01

    The equilibria among the various ionization and tautomeric states involved in the activation of ThDP is addressed using high level density functional theory calculations, X3LYP/6-311++G(d,p)//X3LYP(PB)/6-31++G(d,p). This study provides the first theoretically derived thermodynamic data for the internal equilibria in the activation of ThDP. The role of the medium polarity on the geometry and thermodynamics of the diverse equilibria of ThDP is addressed. The media chosen are cyclohexane and water, as paradigms of apolar and polar media. The results suggest that all ionization and tautomeric states are accessible during the catalytic cycle, even in the absence of substrate, being APH(+) the form required to interconvert the AP and IP tautomers; and the generation of the ylide proceeds via the formation of the IP form. Additionally, the calculated ΔG° values allow to calculate all the equilibrium constants, including the pK(C2) for the thiazolium C2 atom whose ionization is believed to initiate the catalytic cycle.

  17. The X-ray Behavior of Two CVs TT Ari and DP Leo

    CERN Document Server

    Robinson, C R; Robinson, Craig R.; Cordova, France A.

    1993-01-01

    We present ROSAT PSPC observations of the nova-like, or intermediate polar, TT Ari and the eclipsing polar DP Leo. Observations of TT Ari were performed as part of a simultaneous multiwavelength campaign. The X-ray spectrum of TT Ari from ROSAT was combined with Ginga observations to suggest the presence of three distinct emission components: an optically thin plasma, a dominating bremsstrahlung continuum and one or more iron emission lines. Simultaneous and later IUE observations show modulation in the absorption component of the P Cygni-like CIV line on the spectroscopic period indicating a complex wind structure. Three eclipses were observed from the DP Leo system with intensity dips, not previously observed, occurring prior to each eclipse. The dips are interpreted as the eclipse of the main emission region by an accretion stream varying in impact position or stream shape with time. The DP Leo spectrum is well fit by either a 25 eV blackbody or a soft power law. No evidence exists for accretion onto the s...

  18. Strain rate dependent deformation and failure behavior of laser welded DP780 steel joint under dynamic tensile loading

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yang, E-mail: liuyang@mail.neu.edu.cn [Key Laboratory for Anisotropy and Texture of Materials, Ministry of Education, Northeastern University, Shenyang 110819 (China); Dong, Danyang, E-mail: dongdanyang@mail.neu.edu.cn [College of Science, Northeastern University, Shenyang 110819 (China); Wang, Lei, E-mail: wanglei@mail.neu.edu.cn [Key Laboratory for Anisotropy and Texture of Materials, Ministry of Education, Northeastern University, Shenyang 110819 (China); Chu, Xi, E-mail: chuxi.ok@163.com [College of Science, Northeastern University, Shenyang 110819 (China); Wang, Pengfei, E-mail: wpf1963871400@163.com [College of Science, Northeastern University, Shenyang 110819 (China); Jin, Mengmeng, E-mail: 24401878@163.com [College of Science, Northeastern University, Shenyang 110819 (China)

    2015-03-11

    Laser welded DP steel joints are used widely in the automotive industry for weight reduction. Understanding the deformation and fracture behavior of the base metal (BM) and its welded joint (WJ), especially at high strain rates, is critical for the design of vehicle structures. This paper is concerned with the effects of strain rate on the tensile properties, deformation and fracture behavior of the laser welded DP780 steel joint. Quasi-static and dynamic tensile tests were performed on the WJ and BM of the DP780 steel using an electromechanical universal testing machine and a high-speed tensile testing machine over a wide range of strain rate (0.0001–1142 s{sup −1}). The microstructure change and microhardness distribution of the DP780 steel after laser welding were examined. Digital image correlation (DIC) and high-speed photography were employed for the strain measurement of the DP780 WJ during dynamic tensile tests. The DP780 WJ is a heterogeneous structure with hardening in fusion zone (FZ) and inner heat-affected zone (HAZ), and softening in outer HAZ. The DP780 BM and WJ exhibit positive strain rate dependence on the YS and UTS, which is smaller at lower strain rates and becomes larger with increasing strain rate, while ductility in terms of total elongation (TE) tends to increase under dynamic loading. Laser welding leads to an overall reduction in the ductility of the DP780 steel. However, the WJ exhibits a similar changing trend of the ductility to that of the BM with respect to the strain rate over the whole strain rate range. As for the DP780 WJ, the distance of tensile failure location from the weld centerline decreases with increasing strain rate. The typical ductile failure characteristics of the DP780 BM and WJ do not change with increasing strain rate. DIC measurements reveal that the strain localization starts even before the maximum load is attained in the DP780 WJ and gradual transition from uniform strains to severely localized strains

  19. Preformed donor HLA-DP-specific antibodies mediate acute and chronic antibody-mediated rejection following renal transplantation.

    Science.gov (United States)

    Jolly, E C; Key, T; Rasheed, H; Morgan, H; Butler, A; Pritchard, N; Taylor, C J; Clatworthy, M R

    2012-10-01

    Donor-specific HLA alloantibodies may cause acute and chronic antibody-mediated rejection (AMR) and significantly compromise allograft survival. The clinical relevance of antibodies directed against some HLA class II antigens, particularly HLA-DP, is less clear with conflicting reports on their pathogenicity. We report two patients with high levels of pretransplant donor-specific HLA-DP antibodies who subsequently developed recurrent acute AMR and graft failure. In both cases, there were no other donor-specific HLA alloantibodies, suggesting that the HLA-DP-specific antibodies may be directly pathogenic.

  20. Department of Defense Expenditure Plans

    Science.gov (United States)

    2009-03-20

    Buxton Rd. 1,879 E 88 Redstone Arsenal AL Replace Water Main Along Paton Rd. from H.U. to Martin Rd. 1,857 E 89 Redstone Arsenal AL Fy 2009 Annual Road... Buxton Road E. from Patton to H.U. 1,312 E 25 American Recovery and Reinvestment Act of 2009 Operation and Maintenance, Defense Health Program, and...Meet AR 190-11 75 O 1100 Billings AFRC MT Mechanical System Improvements 188 E 1101 Billings AFRC MT Install Lighting Controls 45 E 1102 Billings

  1. April 25, 2003, FY2003 Progress Summary and FY2002 Program Plan, Statement of Work and Deliverables for Development of High Average Power Diode-Pumped Solid State Lasers,and Complementary Technologies, for Applications in Energy and Defense

    Energy Technology Data Exchange (ETDEWEB)

    Meier, W; Bibeau, C

    2005-10-25

    The High Average Power Laser Program (HAPL) is a multi-institutional, synergistic effort to develop inertial fusion energy (IFE). This program is building a physics and technology base to complement the laser-fusion science being pursued by DOE Defense programs in support of Stockpile Stewardship. The primary institutions responsible for overseeing and coordinating the research activities are the Naval Research Laboratory (NRL) and Lawrence Livermore National Laboratory (LLNL). The current LLNL proposal is a companion document to the one submitted by NRL, for which the driver development element is focused on the krypton fluoride excimer laser option. The NRL and LLNL proposals also jointly pursue complementary activities with the associated rep-rated laser technologies relating to target fabrication, target injection, final optics, fusion chamber, target physics, materials and power plant economics. This proposal requests continued funding in FY03 to support LLNL in its program to build a 1 kW, 100 J, diode-pumped, crystalline laser, as well as research into high gain fusion target design, fusion chamber issues, and survivability of the final optic element. These technologies are crucial to the feasibility of inertial fusion energy power plants and also have relevance in rep-rated stewardship experiments. The HAPL Program pursues technologies needed for laser-driven IFE. System level considerations indicate that a rep-rated laser technology will be needed, operating at 5-10 Hz. Since a total energy of {approx}2 MJ will ultimately be required to achieve suitable target gain with direct drive targets, the architecture must be scaleable. The Mercury Laser is intended to offer such an architecture. Mercury is a solid state laser that incorporates diodes, crystals and gas cooling technologies.

  2. Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells.

    Science.gov (United States)

    Merlot, Angelica M; Sahni, Sumit; Lane, Darius J R; Fordham, Ashleigh M; Pantarat, Namfon; Hibbs, David E; Richardson, Vera; Doddareddy, Munikumar R; Ong, Jennifer A; Huang, Michael L H; Richardson, Des R; Kalinowski, Danuta S

    2015-04-30

    Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) demonstrates potent anti-cancer activity. We previously demonstrated that 14C-Dp44mT enters and targets cells through a carrier/receptor-mediated uptake process. Despite structural similarity, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT) and pyridoxal isonicotinoyl hydrazone (PIH) enter cells via passive diffusion. Considering albumin alters the uptake of many drugs, we examined the effect of human serum albumin (HSA) on the cellular uptake of Dp44mT, Bp4eT and PIH. Chelator-HSA binding studies demonstrated the following order of relative affinity: Bp4eT≈PIH>Dp44mT. Interestingly, HSA decreased Bp4eT and PIH uptake, potentially due to its high affinity for the ligands. In contrast, HSA markedly stimulated Dp44mT uptake by cells, with two saturable uptake mechanisms identified. The first mechanism saturated at 5-10 µM (B(max):1.20±0.04 × 10⁷ molecules/cell; K(d):33±3 µM) and was consistent with a previously identified Dp44mT receptor/carrier. The second mechanism was of lower affinity, but higher capacity (B(max):2.90±0.12 × 10⁷ molecules/cell; K(d):65±6 µM), becoming saturated at 100 µM and was only evident in the presence of HSA. This second saturable Dp44mT uptake process was inhibited by excess HSA and had characteristics suggesting it was mediated by a specific binding site. Significantly, the HSA-mediated increase in the targeting of Dp44mT to cancer cells potentiated apoptosis and could be important for enhancing efficacy.

  3. Defense and the Economy

    Science.gov (United States)

    1993-01-01

    AD A 66 28 o’py 9of 27 copiesII AD-A266 288-co, .o,,,, I IDA PAPER P-28 10I * DEFENSE AND THE ECONOMY David R. Graham An-Jen Tai Barbara A...TYPE AND DATES COVERED January 1993 4. TITLE AND SUBTITLE S. FUNDING NUMBERS Defense and the Economy C-MDA 903 89C 0003i...Fomr 298 (Rev 2-4g) 3Preserked by ANSI Sid, Z39- 2I0 I I I IDA PAPER P-2810() 3 DEFENSE AND THE ECONOMY I I David R. Graham An-Jen Tai Barbara A

  4. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

    DEFF Research Database (Denmark)

    Helin, K; Wu, C L; Fattaey, A R;

    1993-01-01

    the hypophosphorylated form of the retinoblastoma protein (pRB). The other protein, murine DP-1, was purified from an E2F DNA-affinity column, and it was subsequently shown to bind the consensus E2F DNA-binding site. To study a possible interaction between E2F-1 and DP-1, we have now isolated a cDNA for the human...... is required for stable interaction with pRB in vivo and that trans-activation by E2F-1/DP-1 heterodimers is inhibited by pRB. We suggest that "E2F" is the activity that is formed when an E2F-1-related protein and a DP-1-related protein dimerize....

  5. Public-Private Partnerships in Defense Acquisition Programs-Defensible?

    Science.gov (United States)

    2009-12-01

    result in PPP implementation (for example, a leasing plan for air tankers in 2001 and a private- sector solution instead of a Joint Simulation System...PPP partner (assuming that PPP mode is selected) would be responsible for providing a turnkey aircrew training facility, including acquiring a fleet of...providing the RSAF with a true turnkey program—everything from courseware to cockpits—that will serve the Republic and its pilot trainees for the

  6. Dual-polarization multi-band OFDM versus single-carrier DP-QPSK for 100 Gb/s long-haul WDM transmission over legacy infrastructure.

    Science.gov (United States)

    Karaki, J; Giacoumidis, E; Grot, D; Guillossou, T; Gosset, C; Le Bidan, R; Le Gall, T; Jaouën, Y; Pincemin, E

    2013-07-15

    The transmission performance of coherent dual-polarization multi-band OFDM (DP-MB-OFDM) and QPSK (DP-QPSK) are experimentally compared for 100 Gb/s long-haul transport over legacy infrastructure combining G.652 fiber and 10 Gb/s WDM system. It is shown that DP-MB-OFDM and DP-QPSK have nearly the same performance at 100 Gb/s after transmission over a 10 × 100-km fiber line. Furthermore, the origin of performance degradations and limitations of the DP-MB-OFDM is explored numerically, as well as the impact of transmission distance and sub-band spacing.

  7. 基于Profibus-DP的智能从站接口设计与应用%Design and Application of Intelligent Slave Interface Based on Profibus-DP

    Institute of Scientific and Technical Information of China (English)

    莫太平; 吴正高; 王丹

    2012-01-01

    为了解决当前一些智能设备无法与现场总线系统进行通信的问题,对Profibus-DP总线协议进行了分析,提出了一种以微控制器与Profibus协议芯片作为核心器件的从站接口设计方案.采用ATMEGA162单片机来处理用户程序,由VPC3+C芯片实现Profibus-DP协议,通过RS485驱动芯片ADM2486与RS232串口电平转换芯片MAX232,完成Profibus-DP总线协议与RS232串口协议之间的转换,实现RS232智能设备与现场总线的连接.已在产品跟踪系统中应用,使用结果表明,从站接口在保证智能设备与现场总线通信稳定可靠的情况下,提高了数据交换的传输速率.%In order to solve the problems that some current intelligent equipment can not communicate with the field-bus system,and analyzed Profibus-DP protocol,proposed a development plan of Profibus-DP intelligent slave interface taking a microcontroller and Profibus protocol chip as the core components. Used single-chip microcomputer AT-MEGA162 to handle the user program and used VPC3+C to implement Profibus-DP protocol,through the RS485 driver chip ADM2486 and RS232 serial level transition chip MAX232,executed conversion between Profibus-DP fieldbus protocol and RS232 serial port protocol,realized connection between RS232 intelligent equipment and field-bus. The slave interface has been applied in product tracking system,the using results show that the slave interface improves the transmission speed of data exchange,in the case guaranteeing the stability and reliability of communication between intelligent equipment and fieldbus.

  8. Defense Science and Technology Success Stories

    Science.gov (United States)

    2007-01-01

    program. POC: Mr. Paul Koskey, MDA/ DVI , 703-882-6154 Year: FY 2006/2007 Fiber Grating Sensor for Damage Assessment MISSILE DEFENSE AGENCY (MDA) 43...sulfur, these microorganisms remove a potentially fouling precipitate from the anode. Collective activity of the biofilm and continuous flux of fuel by

  9. Preformed Donor HLA-DP-Specific Antibodies Mediate Acute and Chronic Antibody-Mediated Rejection Following Renal Transplantation

    OpenAIRE

    Jolly, E. C.; Key, T; H. Rasheed; Morgan, H; Butler, A; Pritchard, N.; Taylor, C J; Clatworthy, M. R.

    2012-01-01

    Donor-specific HLA alloantibodies may cause acute and chronic antibody-mediated rejection (AMR) and significantly compromise allograft survival. The clinical relevance of antibodies directed against some HLA class II antigens, particularly HLA-DP, is less clear with conflicting reports on their pathogenicity. We report two patients with high levels of pretransplant donor-specific HLA-DP antibodies who subsequently developed recurrent acute AMR and graft failure. In both cases, there were no o...

  10. Silica-based PLC with heterogeneously-integrated PDs for one-chip DP-QPSK receiver.

    Science.gov (United States)

    Kurata, Yu; Nasu, Yusuke; Tamura, Munehisa; Kasahara, Ryoichi; Aozasa, Shinichi; Mizuno, Takayuki; Yokoyama, Haruki; Tsunashima, Satoshi; Muramoto, Yoshifumi

    2012-12-10

    To realize a DP-QPSK receiver PLC, we heterogeneously integrated eight high-speed PDs on a silica-based PLC platform with a PBS, 90-degree optical hybrids and a VOA. The use of a 2.5%-Δ waveguide reduced the receiver PLC size to 11 mm x 11 mm. We successfully demonstrated 32 Gbaud DP-QPSK signal demodulation with the receiver PLC.

  11. Adaptation of D-P flap to the oro-facial fistula induced by radio-osteomyelitis of mandible

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, E.; Genba, R.; Hayatsu, Y.; Sunakawa, H.; Kohama, G. (Sapporo Medical Coll. (Japan))

    1980-06-01

    Intraoral partial resection of the mandible was performed on 3 patients with radiation-induced ostomyelitis and ostonecrosis of the mandible, and inflammation in the mandible disappeared. Residual oro-facial fistula was closed with D-P flap, and a good result was obtained. Treatments of radiation osteopathy, the time of the treatments, and the period from resection of necrotic mandible to the closure of the fistula with D-P flap and reconstructive surgery for the mouth were also considered.

  12. Compact 100Gb/s DP-QPSK integrated receiver module employing three-dimensional assembly technology.

    Science.gov (United States)

    Tanobe, H; Kurata, Y; Nakanishi, Y; Fukuyama, H; Itoh, M; Yoshida, E

    2014-03-10

    We demonstrate a compact 100 Gbit/s DP-QPSK receiver module that is only 18 mm (W) x 16 mm (D) x 2.8 mm (H). The module size is reduced by using a ball grid array (BGA) package with three-dimensional assembly technology and by applying a heterogeneous integrated PLC. Error-free DP-QPSK signal demodulation is successfully demonstrated.

  13. Chronic Beryllium Disease: revealing the role of beryllium ion and small peptides binding to HLA-DP2.

    Science.gov (United States)

    Petukh, Marharyta; Wu, Bohua; Stefl, Shannon; Smith, Nick; Hyde-Volpe, David; Wang, Li; Alexov, Emil

    2014-01-01

    Chronic Beryllium (Be) Disease (CBD) is a granulomatous disorder that predominantly affects the lung. The CBD is caused by Be exposure of individuals carrying the HLA-DP2 protein of the major histocompatibility complex class II (MHCII). While the involvement of Be in the development of CBD is obvious and the binding site and the sequence of Be and peptide binding were recently experimentally revealed [1], the interplay between induced conformational changes and the changes of the peptide binding affinity in presence of Be were not investigated. Here we carry out in silico modeling and predict the Be binding to be within the acidic pocket (Glu26, Glu68 and Glu69) present on the HLA-DP2 protein in accordance with the experimental work [1]. In addition, the modeling indicates that the Be ion binds to the HLA-DP2 before the corresponding peptide is able to bind to it. Further analysis of the MD generated trajectories reveals that in the presence of the Be ion in the binding pocket of HLA-DP2, all the different types of peptides induce very similar conformational changes, but their binding affinities are quite different. Since these conformational changes are distinctly different from the changes caused by peptides normally found in the cell in the absence of Be, it can be speculated that CBD can be caused by any peptide in presence of Be ion. However, the affinities of peptides for Be loaded HLA-DP2 were found to depend of their amino acid composition and the peptides carrying acidic group at positions 4 and 7 are among the strongest binders. Thus, it is proposed that CBD is caused by the exposure of Be of an individual carrying the HLA-DP2*0201 allele and that the binding of Be to HLA-DP2 protein alters the conformational and ionization properties of HLA-DP2 such that the binding of a peptide triggers a wrong signaling cascade.

  14. Rethinking Defensive Information Warfare

    Science.gov (United States)

    2004-06-01

    electronic warfare, and special information operations. Defensive information operations ensure timely, accurate, and relevant information access...information and information systems. IA, physical security, OPSEC, counter-deception, counter-psyops, CI, EW, and special information operations. Ensure

  15. Data Science at the Defense Personnel and Security Research Center. Mission: Improve the Effectiveness, Efficiency, and Fairness of DoD Personnel Security and Suitability Programs

    Science.gov (United States)

    2015-05-14

    Mission: Improve the Effectiveness, Efficiency, and Fairness of DoD Personnel Security and Suitability Programs Report Documentation Page Form... fairness of personnel security in the DoD In the wake of events like 9-11, Ft. Hood, and the Washington Navy Yard shootings, we expanded our

  16. Surfing China's National Defense

    Institute of Scientific and Technical Information of China (English)

    Ji Guilin

    2010-01-01

    @@ Following the start of its first test run on August 20, 2009, the website www.mod.gov.cn of the Ministry of National Defense (MOD) of the People's Republic of China has logged more than 2 billion hits,from many countries and regions including China, the United States,the United Kingdom, Japan, Australia and Singapore. China National Defense News reporters recently interviewed Ji Guilin, the website's Editor in Chief, on its performance and the feedback of netizens.

  17. Preparation of Underrepresented Males for Scientific Careers: A Study of the Dr. John H. Hopps Jr. Defense Research Scholars Program at Morehouse College.

    Science.gov (United States)

    Thompson, Rahmelle C; Monroe-White, Thema; Xavier, Jeffrey; Howell, Courtney; Moore, Myisha Roberson; Haynes, J K

    Equal representation within higher education science, technology, engineering, and mathematics (STEM) fields and the STEM workforce in the United States across demographically diverse populations is a long-standing challenge. This study uses two-to-one nearest-neighbor matched-comparison group design to examine academic achievement, pursuit of graduate science degree, and classification of graduate institution attended by students participating in the Hopps Scholars Program (Hopps) at Morehouse College. Hopps is a highly structured enrichment program aimed at increasing participation of black males in STEM fields. Morehouse institutional records, Hopps Program records, and National Student Clearinghouse data were used to examine differences between Hopps and non-Hopps STEM graduates of Morehouse. Two-way sample t tests and chi-square tests revealed significant differences in academic achievement, likelihood of STEM degree pursuit, and the classification of graduate institutions attended by Hopps versus non-Hopps students. Hopps Scholars were significantly more likely than non-Hopps STEM graduates both to pursue STEM doctoral degrees and to attend doctoral-granting institutions with higher research activity. The Hopps Program's approach to training black male students for scientific careers is a model of success for other programs committed to increasing the number of black males pursuing advanced degrees in STEM. © 2016 R. C. Thompson et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  18. MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation

    Directory of Open Access Journals (Sweden)

    Lara Barrio

    2014-07-01

    Full Text Available Multiple conserved mechanisms sense nutritional conditions and coordinate metabolic changes in the whole organism. We unravel a role for the Drosophila homolog of p53 (Dp53 in the fat body (FB; a functional analog of vertebrate adipose and hepatic tissues in starvation adaptation. Under nutrient deprivation, FB-specific depletion of Dp53 accelerates consumption of major energy stores and reduces survival rates of adult flies. We show that Dp53 is regulated by the microRNA (miRNA machinery and miR-305 in a nutrition-dependent manner. In well-fed animals, TOR signaling contributes to miR-305-mediated inhibition of Dp53. Nutrient deprivation reduces the levels of miRNA machinery components and leads to Dp53 derepression. Our results uncover an organism-wide role for Dp53 in nutrient sensing and metabolic adaptation and open up avenues toward understanding the molecular mechanisms underlying p53 activation under nutrient deprivation.

  19. Correlation between 2D and 3D flow curve modelling of DP steels using a microstructure-based RVE approach

    Energy Technology Data Exchange (ETDEWEB)

    Ramazani, A., E-mail: ali.ramazani@iehk.rwth-aachen.de [Department of Ferrous Metallurgy, RWTH Aachen University, Intzestr.1, D-52072 Aachen (Germany); Mukherjee, K.; Quade, H.; Prahl, U.; Bleck, W. [Department of Ferrous Metallurgy, RWTH Aachen University, Intzestr.1, D-52072 Aachen (Germany)

    2013-01-10

    A microstructure-based approach by means of representative volume elements (RVEs) is employed to evaluate the flow curve of DP steels using virtual tensile tests. Microstructures with different martensite fractions and morphologies are studied in two- and three-dimensional approaches. Micro sections of DP microstructures with various amounts of martensite have been converted to 2D RVEs, while 3D RVEs were constructed statistically with randomly distributed phases. A dislocation-based model is used to describe the flow curve of each ferrite and martensite phase separately as a function of carbon partitioning and microstructural features. Numerical tensile tests of RVE were carried out using the ABAQUS/Standard code to predict the flow behaviour of DP steels. It is observed that 2D plane strain modelling gives an underpredicted flow curve for DP steels, while the 3D modelling gives a quantitatively reasonable description of flow curve in comparison to the experimental data. In this work, a von Mises stress correlation factor {sigma}{sub 3D}/{sigma}{sub 2D} has been identified to compare the predicted flow curves of these two dimensionalities showing a third order polynomial relation with respect to martensite fraction and a second order polynomial relation with respect to equivalent plastic strain, respectively. The quantification of this polynomial correlation factor is performed based on laboratory-annealed DP600 chemistry with varying martensite content and it is validated for industrially produced DP qualities with various chemistry, strength level and martensite fraction.

  20. 75 FR 76423 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

    Science.gov (United States)

    2010-12-08

    ... of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of... a closed meeting of the Defense Intelligence Agency National Defense Intelligence College Board...

  1. 76 FR 28960 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

    Science.gov (United States)

    2011-05-19

    ... of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of... a closed meeting of the Defense Intelligence Agency National Defense Intelligence College Board...

  2. 76 FR 28757 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-05-18

    ... of the Secretary Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Notice of Availability (NOA) of Revised Defense Logistics Agency Regulation. SUMMARY: The Defense Logistics...

  3. Defense Small Business Innovation Research Program (SBIR). Volume 3. Air Force Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

    Science.gov (United States)

    1990-04-01

    ALEXANDRIA, VA 22311 CONTRACT NUMBER: F19628-89-C-0127 B J STRALSER TITLE: SPECIAL OPERATIONS COMMUNICATIONS SYSTEM ( SPOCS ) TOPIC# 31 OFFICE: ESD/AVP IDENT...THAT THERE MAY BE A SINGLE SOLUTION TO FULFILLING THOSE CRITICAL REQUIREMENTS. THE SPECIAL OPERATIONS COMMUNICATION SYSTEM ( SPOCS ), USES A PULSE STREAM...PROGRAM - PHASE 1 PAGE 344 BY SERVICE FISCAL YEAR 1989 AF SUBMITTED BY THIS PROPOSAL DESCRIBES THE STEPS NECESSARY TO DEVELOP AN ONLINE GAS

  4. Department of Defense Annual Report on Sexual Harassment and Violence at the Military Service Academies Academic Program Year 2010-2011

    Science.gov (United States)

    2011-12-01

    Rape and Sexual Assault: Reporting to Police and Medical Attention, 1992–2000. Washington, DC: Rennison, Callie Marie . ACADEMIC PROGRAM YEAR 2010...Dr. Christopher Kilmartin is a professor of Psychology at the University of Mary Washington and an expert in the prevention of gender-based violence...charqes prefeiTed (Initiated) 1 # Disciplinary boa -d actions {Initiated) 4 # Nonjudicial punishments (Article 15 UC~1J) 3 #Administrative discha-aes

  5. Survey of Laboratories and Implementation of the Federal Defense Laboratory Diversification Program. Annex B. Department of the Navy Domestic Technology Transfer

    Science.gov (United States)

    1993-10-01

    T2 Program Manager: Angel Carreras , Jr., Code 01B Naval Air Warfare Center Aircraft Division Warminster, PA 18974-5000 2.3.7.3 Publications. The 123...polarizers using holographic techniques. The interference pattern from two intersecting laser beams is used to produce a plane grating in a layer of...photoresist which has been deposited on a layer of conductive material which in turn has been used to coat a substrate. Ion milling reproduces the plane

  6. Defense Small Business Innovation Research Program (SBIR). Volume 2. Navy Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

    Science.gov (United States)

    1990-04-01

    FOUND, FROM EXPERIENCE GAINED ON THE CRITICAL SEA TEST ( CZT ) AND THE LOW FREQUENCY ACOUSTICS (LFA) PROGRAMS, THAT THE ACOUSTIC ENVIRONMENT FOR LONG RANGE...CUSTOM "ROUTING- ASIC , THE IMAGINATION WORKS PROPOSLS A NEW AND INNOVATIVE SOLUTION TO THE HARDWARE/SOFTWARE BOUNDARY PROBLEM, ENABLING A COPROCESSOR TO...AND VLSI CHIPS, INCLUDING VHSIC AND ASIC . THE NUMBER OF WORK STATIONS, COMPUTERS, SOFTWARE PACKAGES, DATA FORMATS, FILE TRANSFER STANDARDS, PLOTTER

  7. Resurrecting KIR2DP1: A Key Intermediate in the Evolution of Human Inhibitory NK Cell Receptors That Recognize HLA-C.

    Science.gov (United States)

    Hilton, Hugo G; Blokhuis, Jeroen H; Guethlein, Lisbeth A; Norman, Paul J; Parham, Peter

    2017-03-01

    KIR2DP1 is an inactive member of the human lineage III KIR family, which includes all HLA-C-specific receptor genes. The lethal, and only, defect in KIR2DP1 is a nucleotide deletion in codon 88. Fixed in modern humans, the deletion is also in archaic human genomes. KIR2DP1 is polymorphic, with dimorphism at specificity-determining position 44. By repairing the deletion, we resurrected 11 alleles of KIR2DP1(F) , the functional antecedent of KIR2DP1 We demonstrate how K44-KIR2DP1(F) with lysine 44 recognized C1(+)HLA-C, whereas T44-KIR2DP1(F) recognized C2(+)HLA-C. Dimorphisms at 12 other KIR2DP1(F) residues modulate receptor avidity or signaling. KIR2DP1 and KIR2DL1 are neighbors in the centromeric KIR region and are in tight linkage disequilibrium. Like KIR2DL1, KIR2DP1 contributed to CenA and CenB KIR haplotype differences. Encoded on CenA, C1-specific K44-KIR2DP1(F) were stronger receptors than the attenuated C2-specific T44-KIR2DP1(F) encoded on CenB The last common ancestor of humans and chimpanzees had diverse lineage III KIR that passed on to chimpanzees but not to humans. Early humans inherited activating KIR2DS4 and an inhibitory lineage III KIR, likely encoding a C1-specific receptor. The latter spawned the modern family of HLA-C receptors. KIR2DP1(F) has properties consistent with KIR2DP1(F) having been the founder gene. The first KIR2DP1(F) alleles encoded K44-C1 receptors; subsequently KIR2DP1(F) alleles encoding T44-C2 receptors evolved. The emergence of dedicated KIR2DL2/3 and KIR2DL1 genes encoding C1 and C2 receptors, respectively, could have led to obsolescence of KIR2DP1(F) Alternatively, pathogen subversion caused its demise. Preservation of KIR2DP1(F) functional polymorphism was a side effect of fixation of the deletion in KIR2DP1(F) by micro gene conversion. Copyright © 2017 by The American Association of Immunologists, Inc.

  8. Doping-Induced Spectral Weight Transfer with d-p Interaction

    Institute of Scientific and Technical Information of China (English)

    曹天德; 李传起; 赵德林; 程国生; 郭胜利

    2003-01-01

    The doping-induced spectral weight transfer is studied by using the d-p model and considering spatial fluctuations in the high-Tc cuprates. The results led by the Cu-O interaction are found as follows: (i) the energy levels are grown inside the charge-transfer gap, (ii) the spectral weight is decreased below EF, and (iii) the d holes at Cu-sites in CuO2 planes are delocalized with hole doping. Both metal-insulator transition and electrons of two states are also discussed.

  9. $J/{\\psi}$ ${\\to}$ $DP$, $DV$ decays in the QCD factorization approach

    CERN Document Server

    Sun, Junfeng; Chang, Qin; Huang, Jinshu; Yang, Yueling

    2016-01-01

    Motivated by the recent measurements on nonleptonic $J/{\\psi}$ weak decays at BESIII and the potential prospects of $J/{\\psi}$ meson at the high-luminosity heavy-flavor experiments, the branching ratios of the two-body nonleptonic $J/{\\psi}$ ${\\to}$ $DP$, $DV$ decays are estimated quantitatively by considering the QCD radiative corrections to hadronic matrix elements with the QCD factorization approach. It is found that the Cabibbo favored $J/{\\psi}$ ${\\to}$ $D_{s}^{-}{\\rho}^{+}$, $D_{s}^{-}{\\pi}^{+}$, $\\overline{D}_{u}^{0}\\overline{K}^{{\\ast}0}$ decays have branching ratios ${\\gtrsim}$ $10^{-10}$, which might be promisingly detectable in the near future.

  10. Construction of exact solutions to the modified forms of DP and CH equations by analytical methods

    Directory of Open Access Journals (Sweden)

    Jalil Manafian Heris

    2015-11-01

    Full Text Available In this work, we establish the exact solutions to the modified forms of Degasperis–Procesi (DP and Camassa–Holm (CH equations. The generalized (G’/G-expansion and generalized tanh-coth methods were used to construct solitary wave solutions of nonlinear evolution equations. The generalized (G’/G-expansion method presents a wider applicability for handling nonlinear wave equations. It is shown that the (G’/G-expansion method, with the help of symbolic computation, provides a straightforward and powerful mathematical tool for solving nonlinear evolution equations in mathematical physics.  

  11. Assessment to enhance Air Force and Department of Defense prototyping for the new defense strategy: a workshop summary

    National Research Council Canada - National Science Library

    Haller, Norm

    2013-01-01

    ...) prototyping for the new defense strategy. This workshop examined of a wide range of prototyping issues, including individual recommendations for a renewed prototype program, application of prototyping as a tool for technology/system...

  12. Cloning and functional analysis of a high DP fructan:fructan 1-fructosyl transferase from Echinops ritro (Asteraceae): comparison of the native and recombinant enzymes.

    Science.gov (United States)

    Van den Ende, Wim; Clerens, Stefan; Vergauwen, Rudy; Boogaerts, David; Le Roy, Katrien; Arckens, Lutgarde; Van Laere, André

    2006-01-01

    Inulin-type fructans are the simplest and most studied fructans and have become increasingly popular as prebiotic health-improving compounds. A natural variation in the degree of polymerization (DP) of inulins is observed within the family of the Asteraceae. Globe thistle (Echinops ritro), artichoke (Cynara scolymus), and Viguiera discolor biosynthesize fructans with a considerably higher DP than Cichorium intybus (chicory), Helianthus tuberosus (Jerusalem artichoke), and Dahlia variabilis. The higher DP in some species can be explained by the presence of special fructan:fructan 1-fructosyl transferases (high DP 1-FFTs), different from the classical low DP 1-FFTs. Here, the RT-PCR-based cloning of a high DP 1-FFT cDNA from Echinops ritro is described, starting from peptide sequence information derived from the purified native high DP 1-FFT enzyme. The cDNA was successfully expressed in Pichia pastoris. A comparison is made between the mass fingerprints of the native, heterodimeric enzyme and its recombinant, monomeric counterpart (mass fingerprints and kinetical analysis) showing that they have very similar properties. The recombinant enzyme is a functional 1-FFT lacking invertase and 1-SST activities, but shows a small intrinsic 1-FEH activity. The enzyme is capable of producing a high DP inulin pattern in vitro, similar to the one observed in vivo. Depending on conditions, the enzyme is able to produce fructo-oligosaccharides (FOS) as well. Therefore, the enzyme might be suitable for both FOS and high DP inulin production in bioreactors. Alternatively, introduction of the high DP 1-FFT gene in chicory, a crop widely used for inulin extraction, could lead to an increase in DP which is useful for a number of specific industrial applications. 1-FFT expression analysis correlates well with high DP fructan accumulation in vivo, suggesting that the enzyme is responsible for high DP fructan formation in planta.

  13. 已经登陆GT6 Aston martin DP-100 VISION Gran Turismo concept

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    大鲶鱼头式的设计充分考虑到空气动力学设定,将下压力尽可能提升,同时减小地面效应。阿斯顿马丁为了吸引更多的游戏爱好者,在著名的赛车游戏Gran Turismo 6当中推出了全新概念车DP-100 vision Gran Turismo。事实上这款全新概念车并未生产出真车,哪怕连油泥模型也都没有,仅仅存在于GT6游戏当中,并且可以通过下载的方式得到。这部全新概念车由阿断顿马丁英国总部以CC100 Speedster概念车为蓝本打造,采用了更夸张和更大胆的设计手法,反正也是在游戏里,有多夸张都不为过。前部硕大的进气格栅内嵌式激光大灯还有碎片式尾灯都是DP-100 visior Gran Turismo的独特之处。

  14. Design and Reliability Analysis of DP-3 Dynamic Positioning Control Architecture

    Institute of Scientific and Technical Information of China (English)

    WANG Fang; WAN Lei; JIANG Da-peng; XU Yu-ru

    2011-01-01

    As the exploration and exploitation of oil and gas proliferate throughout deepwater area,the requirements on the reliability of dynamic positioning system become increasingly stringent.The control objective ensuring safety operation at deep water will not be met by a single controller for dynamic positioning.In order to increase the availability and reliability of dynamic positioning control system,the triple redundancy hardware and software control architectures were designed and developed according to the safe specifications of DP-3 classification notation for dynamically positioned ships and rigs.The hardware redundant configuration takes the form of triple-redundant hot standby configuration including three identical operator stations and three real-time control computers which connect each other through dual networks.The function of motion control and redundancy management of control computers were implemented by software on the real-time operating system VxWorks.The software realization of task loose synchronization,majority voting and fault detection were presented in details.A hierarchical software architecture was planed during the development of software,consisting of application layer,real-time layer and physical layer.The behavior of the DP-3 dynamic positioning control system was modeled by a Markov model to analyze its reliability.The effects of variation in parameters on the reliability measures were investigated.The time domain dynamic simulation was carried out on a deepwater drilling rig to prove the feasibility of the proposed control architecture.

  15. Friction Stir Spot Welding of DP780 and Hot-Stamp Boron Steels

    Energy Technology Data Exchange (ETDEWEB)

    Santella, Michael L.; Frederick, Alan; Hovanski, Yuri; Grant, Glenn J.

    2008-05-16

    Friction stir spot welds were made in two high-strength steels: DP780, and a hot-stamp-boron steel with tensile strength of 1500 MPa. The spot welds were made at either 800 or 1600 rpm using either of two polycrystalline boron nitride tools. One stir tool, BN77, had the relatively common pin-tool shape. The second tool, BN46, had a convex rather than a concave shoulder profile and a much wider and shorter pin. The tools were plunged to preprogrammed depths either at a continuous rate (1-step schedule) or in two segments consisting of a relatively high rate followed by a slower rate. In all cases, the welds were completed in 4s. The range of lap-shear values were compared to values required for resistance spot welds on the same steels. The minimum value of 10.3 kN was exceeded for friction stir spot welding of DP780 using a 2-step schedule and either the BN77- or the BN46-type stir tool. The respective minimum value of 12 kN was also exceeded for the HSB steel using the 2-step process and the BN46 stir tool.

  16. Microstructure and mechanical properties of laser welded DP600 steel joints

    Energy Technology Data Exchange (ETDEWEB)

    Farabi, N. [Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3 (Canada); Chen, D.L., E-mail: dchen@ryerson.ca [Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3 (Canada); Li, J.; Zhou, Y. [Department of Mechanical and Mechatronics Engineering, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1 (Canada); Dong, S.J. [School of Mechanical Engineering, Hubei University of Technology, Wuhan, Hubei (China)

    2010-02-15

    To reduce fuel consumption and greenhouse gas emissions, dual phase (DP) steels have been considered for automotive applications due to their higher tensile strength, better initial work hardening along with larger elongation compared to conventional grade of steels. In such applications welding and joining have to be involved, which would lead to a localized alteration of materials and create potential safety and reliability issues under cyclic loading. The aim of this investigation was to evaluate microstructural change after laser welding and its effect on the tensile and fatigue properties in DP600 steel. The welding resulted in a significant increase of hardness in the fusion zone, but also the formation of a soft zone in the outer heat-affected zone (HAZ). While the ductility decreased after welding, the yield strength increased and the ultimate tensile strength remained almost unchanged. Fatigue life at higher stress amplitudes was almost the same between the base metal and welded joints despite slightly lower fatigue limit after welding. Tensile fracture and fatigue failure at higher stress amplitudes occurred at the outer HAZ. Fatigue crack initiation was observed to occur from the specimen surface and crack propagation was characterized by the characteristic mechanism of striation formation. Dimples and deformation bands were observed in the fast propagation area.

  17. Tensile and Spring-Back Behavior of DP600 Advanced High Strength Steel at Warm Temperatures

    Institute of Scientific and Technical Information of China (English)

    F Ozturk; S Toros; S Kilic

    2009-01-01

    In recent years, the use of advanced high strength steels in automotive industry has been increased remark-ably. Among advanced high strength steels, dual phase (DP)steels have gained a great attention owing to a combi-nation of high strength and good formability. However, high strength usually increases the spring-back behavior of the material, which creates problems for the parts during the assembly. Thus, the uniaxial tensile deformation and spring-back behaviors of DP600 advanced high strength steel were investigated in rolling (0°), diagonal (45°), and transverse (90°)directions in the temperature range from room temperature (RT)to 300 ℃. All tests were per-formed at a deformation speed of 25 mm/min. A V-shaped die (60°)was used for the spring-back measurements. The results indicated that the formability and spring-back of the material were decreased with increasing the tempera-tures. The material showed complex behaviors in different directions and at different temperatures.

  18. A versatile floating production unit: the DP FPSO for Brazilian waters

    Energy Technology Data Exchange (ETDEWEB)

    Cann, Bram Van; Poldervaart, Leen [SBM Inc., Marly (Switzerland); Beenen, Marco [Gusto Engineering B.V. (Netherlands)

    2004-07-01

    Recent advances in drilling and completion techniques have resulted in improved well system design and completion reliability. Extended reach wells, multi-laterals, smart wells producing from multiple pay-zones and a range of completion methods provide high well production rates and significant recoverable reserves per well. During the initial phase of a field development, limited or no data may be available concerning the hydrocarbon reservoir. An extended well test facility or early production facility can provide additional high-quality production data related to properties of the recovered hydrocarbons, reservoir drive mechanism, reservoir pressure and temperature, etc. By obtaining critical reservoir and production data during the initial project phase, technical and commercial risks can be further quantified and a possible field development plan optimized. With exploration and production operations in deeper water, the cost for traditional (passive) station keeping systems of floating offshore structures has increased accordingly. Hardware and offshore installation costs associated with a passive mooring system of a floating offshore facilities can be significant, especially in case of operations in remote deep water areas and with frequent relocations. A DP system provides a cost-effective and proven means of station keeping and has been extensively applied to deep water drilling units. Operating as a first-stage field development unit, the DP-FPSO will enable a cost-effective means to gain valuable reservoir and production data, while generating early sales revenues. (author)

  19. Proceedings of the Electronic Test Equipment Division’s Annual Program Review of ’Electronic Test Equipment Industry Response to Emerging Defense Requirements’ Held in Arlington, VA on 10-11 May 1984

    Science.gov (United States)

    1984-01-01

    J j ELECTRONIC TEST EQUIPMENT INDUSTRY RESPONSE TO EMERGING DEFENSE REQUIREMENTS TECHNICAL LIBRARY held at the Hyatt Arlington Hotel ...Deputy Under Secretary of Defense for Acquisition Mangement KEYNOTE ADDRESS 13 LtG. Donald M. Babers, Deputy Commanding General for Material

  20. Defense styles of pedophilic offenders.

    Science.gov (United States)

    Drapeau, Martin; Beretta, Véronique; de Roten, Yves; Koerner, Annett; Despland, Jean-Nicolas

    2008-04-01

    This pilot study investigated the defense styles of pedophile sexual offenders. Interviews with 20 pedophiles and 20 controls were scored using the Defense Mechanisms Rating Scales. Results showed that pedophiles had a significantly lower overall defensive functioning score than the controls. Pedophiles used significantly fewer obsessional-level defenses but more major image-distorting and action-level defenses. Results also suggested differences in the prevalence of individual defenses where pedophiles used more dissociation, displacement, denial, autistic fantasy, splitting of object, projective identification, acting out, and passive aggressive behavior but less intellectualization and rationalization.

  1. The molecular origin of the thiamine diphosphate-induced spectral bands of ThDP-dependent enzymes.

    Science.gov (United States)

    Kovina, Marina V; De Kok, Aart; Sevostyanova, Irina A; Khailova, Ludmila S; Belkina, Natalya V; Kochetov, German A

    2004-08-01

    New and previously published data on a variety of ThDP-dependent enzymes such as baker's yeast transketolase, yeast pyruvate decarboxylase and pyruvate dehydrogenase from pigeon breast muscle, bovine heart, bovine kidney, Neisseria meningitidis and E. coli show their spectral sensitivity to ThDP binding. Although ThDP-induced spectral changes are different for different enzymes, their universal origin is suggested as being caused by the intrinsic absorption of the pyrimidine ring of ThDP, bound in different tautomeric forms with different enzymes. Non-enzymatic models with pyrimidine-like compounds indicate that the specific protein environment of the aminopyrimidine ring of ThDP determines its tautomeric form and therefore the changeable features of the inducible effect. A polar environment causes the prevalence of the aminopyrimidine tautomeric form (short wavelength region is affected). For stabilization of the iminopyrimidine tautomeric form (both short- and long-wavelength regions are affected) two factors appear essential: (i) a nonpolar environment and (ii) a conservative carboxyl group of a specific glutamate residue interacting with the N1' atom of the aminopyrimidine ring. The two types of optical effect depend in a different way upon the pH, in full accordance with the hypothesis tested. From these studies it is concluded that the inducible optical rotation results from interaction of the aminopyrimidine ring with its asymmetric environment and is defined by the protonation state of N1' and the 4'-nitrogen.

  2. 32 CFR 555.8 - Program documentation.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Program documentation. 555.8 Section 555.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND... TESTS, WORK FOR OTHERS § 555.8 Program documentation. Program documentation will be submitted...

  3. Technology Commercialization Program 1991

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This reference compilation describes the Technology Commercialization Program of the Department of Energy, Defense Programs. The compilation consists of two sections. Section 1, Plans and Procedures, describes the plans and procedures of the Defense Programs Technology Commercialization Program. The second section, Legislation and Policy, identifies legislation and policy related to the Program. The procedures for implementing statutory and regulatory requirements are evolving with time. This document will be periodically updated to reflect changes and new material.

  4. Defense Business Transformation

    Science.gov (United States)

    2009-12-01

    other. SCM and ERP systems both contribute to the overall distribution and coordination of resources. Just as an ERP enhances information flow...inventory management system (Thureen 2008). It combines the Army’s disparate wholesale and retail inventories, into one combined system (Sparacino 2002...Studies.............................................................................. 73 1. Defense Integrated Military Human Resource System

  5. Robust Preallocated Preferential Defense.

    Science.gov (United States)

    1985-08-01

    Frye , W.H. and Ullman, L.L., Methodology for Calculating Minuteman Defense Effectiveness, SRD-EGI4, Stanford Research Institute, October 1973. 4. Hogg...Corporation 1500 Wilson Boulevard Arlington, VA 22209 ATTN: Dr. Tucker Battle Dr. James Skouras Dr. Iram Weinstein Northrop Corporation 8900 E. Washington

  6. Analysis of HLA-DP association with beryllium disease susceptibility in pooled exposed populations

    Energy Technology Data Exchange (ETDEWEB)

    Cesare Saltini, Massimo Amicosante

    2009-12-19

    Berylliosis or Chronic Beryllium Disease is a chronic granulomatous disorder primarily involving the lung associated with the exposition to low doses of Beryllium (Be) in the workplace. Berylliosis risk has been associated with the presence of a glutamate at position 69 of the HLA-DP beta chain (HLA-DPbetaGlu69) that is expressed in about 97% of disease cases and in 27% of the unaffected Be-exposed controls (p<0.0001) (Richeldi et al. Science 1993; 262: 242-244.12). Since this first observation of an immunogenetic association between berylliosis and HLA-DPbetaGlu69 a number of studies have confirmed the role of this marker as the primary gene of susceptibility of berylliosis (Richeldi et al Am J Ind Med. 1997; 32:337-40; Wang et al J. Immunol. 1999; 163: 1647-53; Saltini et al Eur Respir J. 2001 18:677-84; Rossman et al Am J Respir Crit Care Med. 2002 165:788-94). Moreover, a structure/function interaction between HLA-DP molecules carrying Glu69 and beryllium in driving and developing the immune response against beryllium itself has been observed as: (1) Be-specific T-cells clones obtained from berylliosis patients recognize beryllium as antigen only when presented in the context of the HLA-DP{beta}Glu69 molecules but not in the context of HLA-DP allelic variants carrying Lys69 (Lombardi G et al. J Immunol 2001; 166: 3549-3555), and (2) beryllium presents an affinity for the HLA-DP2, carrying the berylliosis marker of susceptibility HLA-DPGlu69, from 40 to 100 times higher that the HLA-DP molecule carrying Lys69 (Amicosante M. et al Hum. Immunol. 2001; 62: 686-93). However, although the immunogenetic studies performed have been addressed a number of different questions about the genetic association between berylliosis and/or beryllium sensitization, exposure levels to beryllium and HLA markers, a number of questions are still open in the field mainly due to the limitation imposed by the low number of subjects carrying berylliosis or beryllium sensitization enrolled

  7. Hybrid opto-digital signal processing in 112 Gbit/s DP-16QAM and DP-QDB transmission for long-haul large-Aeff pure-silica-core fiber links

    DEFF Research Database (Denmark)

    Asif, Rameez; Ahmad, Ramshah; Basir, Rabeea

    2016-01-01

    By means of numerical simulations, we demonstrated that all-optical signal processing methods (XPM-suppressor module and in-line nonlinear equalization) significantly increase the system performance of digital nonlinear compensation (digital backward propagation) and improve the system performanc...... in five-channel 112 Gbit/s DP-16QAM and DP-QDB transmission over 2400 km large- effective-area pure-silica-core fiber ((Formula presented.)-PSCF). The system performance is quantified with the help of Q-factor (dB) for both dispersion-managed and nondispersion-managed fiber links....

  8. 探讨电穿孔法介导转染32DP210细胞的参数%Investigation on optimal parameters of electroporation-mediated transfection in 32DP210

    Institute of Scientific and Technical Information of China (English)

    吕远栋; 王雅珍; 徐伟红; 陶萍华; 林兵

    2012-01-01

    Objective:To find the best parameters to transfect plasmid Pg into 32DP210 cells. Methods; Iipo-fectamineTM2000, transfast, liposome DMRIC — E transfection and electroporation were compared for transfecting plasmid pG,a plasmid that expressed G418 resistance protein and green fluorescent protein (GFP) , into 32DP210 cells. The expression of GFP was observed and the transient transfection efficiency was measured after the transfection by fluorescence microscope. The stable transfected cells were screened by G418. Results: The optimum conditions for laboratory electroporation — mediated 32DP210 cell transfection were; power transfer voltage 270 V, capacitance of 950 μF, DNA dose of 14 μg. Transfection efficiency of electroporation after 48 h was 50. 81% , while the other three methods were less than 3%. Conclusion; Electroporation is the best way to stably transfect plasmid pG into 32DP210 cells., c%目的:采用电穿孔法将质粒pGenesil -1(简称pG)转染32DP210细胞,从中寻找最佳的参数.方法:分别采用LipofectamineTM2000、transfast、脂质体DMRIC -E和电穿孔法,将能表达G418抗性蛋白和绿色荧光蛋白(GFP)的质粒pG转染32DP210细胞;荧光显微镜下观察GFP表达并测定瞬时转染率;通过G418筛选得到稳定转染的细胞.结果:本实验室电穿孔法介导的32DP210细胞转染其最佳电转条件为电压270 V,电容950μF,DNA剂量14 μg.48 h后电穿孔法的转染效率达50.81%,其它三种方法转染效率都小于3%.结论:用电穿孔法将质粒pG转染32DP210细胞是最佳的转染方法.

  9. Defense Planning in the Ministry of Defense of Ukraine: Decade of Attempts and Mistakes

    Science.gov (United States)

    2015-06-01

    should be done by using the IAS for a modeling situation (for instance, JWARS—Joint Warfare System) or IAS which can carry out a SWOT analysis (IAS...43  C.  MISTAKE ANALYSIS OF CONDUCTED DEFENSE REVIEW IN MDU...PROGRAMS ...................................................64  B.  ANALYSIS OF PLANNING AND EXECUTING FINANCIAL RESOURCES OF MDU

  10. Forward- and Reverse-Traveling Waves in DP Phenomenology: Does Inverted Direction of Wave Propagation Occur in Classical Models?

    Science.gov (United States)

    Sisto, Renata; Shera, Christopher A.; Moleti, Arturo; Botti, Teresa

    2013-01-01

    Recent basilar-membrane (BM) vibration experiments show that the phase slope of the distortion product (DP) in the cochlear region in which a backward-traveling wave is expected is negative, which is typical of a forward-traveling wave, according to the predictions of quasi-linear approximate solutions of classical 1-D transmission-line cochlear models. This phase behavior has been interpreted as suggesting a strong deviation from the “classical” models of the otoacoustic emission (OAE) generation and transmission. In this paper, the DP phase inversion phenomenon is approached from a conservative point of view. The DP phase is calculated in a classical cochlear model. The main conclusion is that deviations from the classical model are not necessary to account for the observed phase behavior. PMID:24376285

  11. Forward- and Reverse-Traveling Waves in DP Phenomenology: Does Inverted Direction of Wave Propagation Occur in Classical Models?

    Science.gov (United States)

    Sisto, Renata; Shera, Christopher A.; Moleti, Arturo; Botti, Teresa

    2011-11-01

    Recent basilar-membrane (BM) vibration experiments show that the phase slope of the distortion product (DP) in the cochlear region in which a backward-traveling wave is expected is negative, which is typical of a forward-traveling wave, according to the predictions of quasi-linear approximate solutions of classical 1-D transmission-line cochlear models. This phase behavior has been interpreted as suggesting a strong deviation from the "classical" models of the otoacoustic emission (OAE) generation and transmission. In this paper, the DP phase inversion phenomenon is approached from a conservative point of view. The DP phase is calculated in a classical cochlear model. The main conclusion is that deviations from the classical model are not necessary to account for the observed phase behavior.

  12. Results of Membrane-Activated Chelator Stroke Intervention randomized trial of DP-b99 in acute ischemic stroke.

    Science.gov (United States)

    Lees, Kennedy R; Bornstein, Natan; Diener, Hans-Christoph; Gorelick, Philip B; Rosenberg, Gilad; Shuaib, Ashfaq

    2013-03-01

    DP-b99, a lipophilic moderate-affinity chelator of zinc, was postulated to improve recovery after acute ischemic stroke. We evaluated the safety and therapeutic effects of DP-b99 in patients with acute hemispheric ischemic stroke. The Membrane-Activated Chelator Stroke Intervention trial was a randomized, double-blind, placebo-controlled, multicenter, parallel-group trial of intravenous DP-b99 administered for 4 consecutive days (NCT00893867). Acute ischemic stroke patients within 9 hours of onset, but untreated by alteplase, with a baseline National Institutes of Health Stroke Scale score of 10 to 16, and evidence of language dysfunction, visual field defect, and neglect were eligible. The primary efficacy analysis compared distributions of functional status measured by modified Rankin score in the intent-to-treat population of patients with any post-treatment outcome, adjusted for initial severity. Functional and neurological recovery were secondary measures. Home time was an exploratory end point. Enrollment terminated at n=446 after the planned interim analysis determined futility; follow-up continued. Final modified Rankin score distributions were equal between DP-b99 and placebo-treated groups (P=0.10; P(adj) adjusted for baseline age and National Institutes of Health Stroke Scale=0.21). Fewer patients recovered to modified Rankin score ≤1 in the DP-b99-treated group (45/218; 20.6%) than after placebo (63/219; 28.8%) (P=0.05; P(adj)=0.10). Similarly, fewer patients attained National Institutes of Health Stroke Scale ≤1 after DP-b99 (42/218; 19.3%) than placebo (56/219; 25.6%; P=0.10; P(adj)=0.26). Mortality was similar between DP-b99 and placebo intent-to-treat groups (36/218; 16.5% vs 33/219; 15.1%; P=0.68). Home time was unchanged by treatment (median 36 vs 36.5 days; P=0.25). Despite encouraging preclinical and phase II trial data, DP-b99 shows no evidence of efficacy in treating human ischemic stroke.

  13. Parametric study on numerical simulation of the electromagnetic forming of DP780 steel workpiece with aluminium driver sheet

    Science.gov (United States)

    Park, Hyeonil; Lee, Jinwoo; Kim, Se-Jong; Lee, Youngseon; Kim, Daeyong

    2016-08-01

    The purpose of this study is to investigate the influences of numerical parameters on the electromagnetic forming (EMF) simulation. The 3-dimensional coupled electromagnetic- mechanical simulations were conducted to predict the deformation behavior of the advanced high strength steel (AHSS) sheet receiving support in EMF with aluminum driver sheet. Dual phase (DP) 780 steel workpiece was formed into a hemi elliptical protrusion shape with aluminum alloy AA1050 driver sheet using a flat spiral coil actuator and open cavity die. The deformed shape of the DP780 workpiece and the computation time with respect to element size, N cycle number and time step of electromagnetic (EM) solver were analysed.

  14. Isospin effects in the exclusive dp -> 3He{\\pi}+{\\pi}- reaction

    CERN Document Server

    Mielke, M; Chiladze, D; Dymov, S; Fritzsch, C; Gebel, R; Goslawski, P; Hartmann, M; Kacharava, A; Khoukaz, A; Kulessa, P; Lorentz, B; Mersmann, T; Mikirtychiants, S; Ohm, H; Papenbrock, M; Rausmann, T; Serdyuk, V; Ströher, H; Täschner, A; Valdau, Y; Wilkin, C

    2014-01-01

    The differential cross section for the exclusive dp -> 3He{\\pi}+{\\pi}- reaction has been measured with high resolution and large statistics over a large fraction of the backward 3He hemisphere at the excess energy 265 MeV using the COSY-ANKE magnetic spectrometer. Though the well-known ABC enhancement is observed in the {\\pi}+{\\pi}- spectrum, the differences detected between the {\\pi}+3He and {\\pi}-3He invariant-mass distributions show that there must be some isospin-one {\\pi}{\\pi} production even at relatively low excess energies. The invariant-mass differences are modeled in terms of the sequential decay N*(1440) -> Delta(1232){\\pi} -> N{\\pi}{\\pi}.

  15. Fluorescence dynamics of interactions between polyamide PyPyPyβDp and DNA

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Huijuan; WANG; Jin; WU; Yishi; YUAN; Gu; AI; Xicheng; WANG; Li

    2006-01-01

    The photophysical properties of the polyamide PyPyPyβDp (PPP) were investigated by means of steady-state absorption and fluorescence spectroscopies, as well as time-resolved fluorescence spectroscopy. It was found that the excited-state properties of PPP are very sensitive to solvents. In TKMC buffer PPP exhibited weak fluorescence with a decay time constant of 16 ps, while with the decrease of the solvent polarity PPP showed the blue-shifted peak position, increased intensity and lengthened life-time for its fluorescence behavior. In the presence of calf thymus DNA, it was observed that the fluorescence intensity was enhanced and the fluorescence lifetime increased from 16 to 32 ps for PPP, which verified that PPP bound into the minor groove of DNA duplex.

  16. Burst Mode Receiver for 112 Gb/s DP-QPSK with parallel DSP.

    Science.gov (United States)

    Thomsen, Benn C; Maher, Robert; Millar, David S; Savory, Seb J

    2011-12-12

    A burst mode 112 Gb/s DP-QPSK digital coherent optical receiver with parallel DSP suitable for implementation in a CMOS ASIC with a 218.75 MHz clock speed is presented. The receiver performance is validated in a five channel 50 GHz grid WDM burst switching experiment using a commercially available wavelength tunable laser as the local oscillator. A new equalizer initialization scheme that overcomes the degenerate convergence problem and ensures rapid convergence is introduced. We show that the performance of the tunable local oscillator is commensurate with burst mode coherent reception when differential decoding in employed and that required parallel DSP implementation does not seriously impair the polarization and frequency tracking performance of a digital coherent receiver under burst mode operation. We report a burst acquisition time of less than 200 ns.

  17. Analog domain adaptive equalizer for low power 40 Gbps DP-QPSK receivers

    Indian Academy of Sciences (India)

    Nandakumar Nambath; Pawan Kumar Moyade; Allmin Ansari; Shalabh Gupta

    2014-04-01

    Electrical domain equalization of chromatic and polarization mode dispersion is attractive in coherent optical communication links. Digital coherent receivers used for this purpose are based on high speed ADCs followed by DSP, which dissipate excessive amount of power and are very costly to implement. We propose analog coherent receiver to drastically reduce the power consumption, size and cost. An adaptive feed forward equalizer for 40 Gbps dual polarization quadrature phase shift keying (DP-QPSK) systems, which processes signals in analog domain itself, is demonstrated using circuit and system simulations. The equalizer, designed in 90 nm CMOS technology, consumes 450 mW of power and occupies 1.8 mm × 1.1 mm chip area. System simulations are used to show that blind equalization is also possible when this approach is used in decision directed mode.

  18. Neutron capture surrogate reaction on 75As in inverse kinematics using (d,p )

    Energy Technology Data Exchange (ETDEWEB)

    Peters, W. A. [Rutgers University; Cizewski, J. A. [Rutgers University; Hatarik, Robert [Rutgers University; O' Malley, Patrick [Rutgers University; Jones, K. L. [University of Tennessee; Schmitt, Kyle [University of Tennessee; Moazen, Brian [University of Tennessee; Chae, K. Y. [University of Tennessee; Pittman, S. T. [University of Tennessee, Knoxville (UTK); Kozub, R. L. [Tennessee Technological University; Vieira, D. J. [Los Alamos National Laboratory (LANL); Jandel, M. [Los Alamos National Laboratory (LANL); Wilhelmy, J. B. [Los Alamos National Laboratory (LANL); Matei, Catalin [Oak Ridge Associated Universities (ORAU); Escher, J. [Lawrence Livermore National Laboratory (LLNL); Bardayan, Daniel W [ORNL; Pain, Steven D [ORNL; Smith, Michael Scott [ORNL

    2010-01-01

    The 75As(d,p ) reaction in inverse kinematics as a surrogate for neutron capture was performed at Oak Ridge National Laboratory using a deuterated plastic target. The intensity of the 165 keV -ray from 76As in coincidence with ejected protons, from exciting 76As above the neutron separation energy populating a compound state, was measured. A tight geometry of four segmented germanium clover -ray detectors together with eight ORRUBA-type silicon-strip charged-particle detectors were used to optimize geometric acceptance. The preliminary analysis of the 75As experiment and the ecacy and future plans of the (d,p ) surrogate campaign in inverse kinematics are discussed.

  19. Experimental Evaluation of Impairments in Unrepeatered DP-16QAM Link with Distributed Raman Amplification

    Directory of Open Access Journals (Sweden)

    Xiaodan Pang

    2017-03-01

    Full Text Available The transmission impairments of a Raman amplified link using dual-polarization 16-quadrature amplitude modulation (DP-16QAM are experimentally characterized. The impact of amplitude and phase noise on the signal due to relative intensity noise (RIN transfer from the pump are compared for two pumping configurations: first-order backward pumping and bi-directional pumping. Experimental results indicate that with increased Raman backward pump power, though the optical signal-to-noise ratio (OSNR is increased, so is the pump-induced amplitude and phase noise. The transmission performance is firstly improved by the enhanced OSNR at a low pump power until an optimum point is reached, and then the impairments due to pump-induced noise start to dominate. However, the introduction of a low pump power in the forward direction can further improve the system’s performance.

  20. Characterization of Microstructure and Mechanical Properties of Resistance Spot Welded DP600 Steel

    Directory of Open Access Journals (Sweden)

    Ali Ramazani

    2015-09-01

    Full Text Available Resistance spot welding (RSW as a predominant welding technique used for joining steels in automotive applications needs to be studied carefully in order to improve the mechanical properties of the spot welds. The objectives of the present work are to characterize the resistance spot weldment of DP600 sheet steels. The mechanical properties of the welded joints were evaluated using tensile-shear and cross-tensile tests. The time-temperature evolution during the welding cycle was measured. The microstructures observed in different sites of the welds were correlated to thermal history recorded by thermocouples in the corresponding areas. It was found that cracks initiated in the periphery region of weld nuggets with a martensitic microstructure and a pull-out failure mode was observed. It was also concluded that tempering during RSW was the main reason for hardness decrease in HAZ.

  1. Draw-Bending Analysis of a Cold Rolled DP980 Steel Sheet

    Science.gov (United States)

    Verma, Rahul K.; Noma, Nobuyasu; Chung, Kwansoo; Kuwabara, Toshihiko

    2011-05-01

    To assess the springback prediction accuracy of the recently proposed model (Verma et. al., 2011), simulations for tension-compression (TC) and draw-bending of a cold rolled DP980 steel sheet (Noma and Kuwabara, 2010b) were performed. Using a rotating die and a specimen specially designed to introduce the uniaxial state of stress during the draw bending test, friction could be neglected and the shape of the yield surface did not play any role in accurate simulations. The effects of incorporating permanent softening and the plastic strain dependent Young's modulus were studied in detail and it was found that the incorporation of permanent softening and the plastic strain dependent Young's modulus both was important for accurate springback prediction.

  2. Influence of hydrogen on formability and bendability of DP1180 steel for car body application

    Science.gov (United States)

    Gao, Q.; Han, F.; Wortberg, D.; Bleck, W.; Liewald, M.

    2016-11-01

    In order to reach future light weight targets, it is increasing necessary to use advanced high strength steels with tensile strength 980 MPa or higher in automotive body-inwhite structures. Due to the sensitivity to hydrogen embrittlement and the limited understanding of various aspects of hydrogen embrittlement on processing and function, the wide application of these steels is still limited. In the current work, the influence of hydrogen on the multiaxial forming behavior was investigated by determining the forming limit curve and bending limit curve of DP1180 steel. Hydrogen concentration in the material was modified by cathodic charging. Then Nakajima tests on hydrogen uncharged and pre-charged samples were carried out in order to adjust and study different strain states resulting in the forming limit curve. In the study of bending limit curve, the steel sheets were pre-strained by Marciniak test. Bending load on the uncharged and pre-charged samples was introduced by VDA238-100 bending tests. The experimental results indicated that the presence of hydrogen affected the formability and bendability of DP1180 steel. A clear difference in the influence of hydrogen at different strain states was observed. When formed in a biaxial strain state via the Nakajima test, the material showed the highest degradation in formability. Moreover, the samples with biaxial pre-loading showed more degradation in bendability comparing to those pre-strained in plane strain and uni-axial paths. Fractography by scanning electron microscope gave evidence of hydrogen-induced cleavage fracture on pre-charged Nakajima samples. Thus this investigation improves the understanding of influences of hydrogen on forming processes and provides important evidence for further studies on HE susceptibility of AHSS for the application on car body constructions.

  3. Latitudinal profile of the ionospheric disturbance dynamo magnetic signature: comparison with the DP2 magnetic disturbance

    Directory of Open Access Journals (Sweden)

    K. Z. Zaka

    2009-09-01

    Full Text Available During magnetic storms, the auroral electrojets intensification affects the thermospheric circulation on a global scale. This process which leads to electric field and current disturbance at middle and low latitudes, on the quiet day after the end of a storm, has been attributed to the ionospheric disturbance dynamo (Ddyn. The magnetic field disturbance observed as a result of this process is the reduction of the H component amplitude in the equatorial region which constitutes the main characteristic of the ionospheric disturbance dynamo process, associated with a westward electric current flow. The latitudinal profile of the Ddyn disturbance dynamo magnetic signature exhibits an eastward current at mid latitudes and a westward one at low latitudes with a substantial amplification at the magnetic equator. Such current flow reveals an "anti-Sq" system established between the mid latitudes and the equatorial region and opposes the normal Sq current vortex. However, the localization of the eastward current and consequently the position and the extent of the "anti-Sq" current vortex changes from one storm to another. Indeed, for a strong magnetic storm, the eastward current is well established at mid latitudes about 45° N and for a weak magnetic storm, the eastward current is established toward the high latitudes (about 60° N, near the Joule heating region, resulting in a large "anti-Sq" current cell. The latitudinal profile of the Ddyn disturbance as well as the magnetic disturbance DP2 generated by the mechanism of prompt penetration of the magnetospheric convection electric field in general, show a weak disturbance at the low latitudes with a substantial amplification at the magnetic equator. Due to the intensity of the storm, the magnitude of the DP2 appears higher than the Ddyn over the American and Asian sector contrary to the African sector.

  4. Clinical Study of Endostar Combined with DP Protocol in Treatment of Advanced Esophageal Cancer

    Directory of Open Access Journals (Sweden)

    Wen-ying DENG

    2015-09-01

    Full Text Available Objective: To observe the clinical outcomes of Endostar combined with DP regimen for treating advanced esophageal cancer.Methods: A total of 62 patients with advanced esophageal cancer admitted from May, 2011 to May, 2013 were enrolled for a prospective, randomized controlled trial and 2 cases were excluded from the study because of Ⅳ degree of digestive tract reaction and myelosuppression. Therefore, 60 cases could be evaluated, and then divided into combined group (given Endostar+DP plan and single chemotherapy group, 30 cases in each group. The level of VEGF, tumor size and CT perfusion (CTP parameters, including blood flow (BF, blood volume (BV, mean transit time (MTT, and permeability surface (PS before and after treatment were determined for comparison. Kaplan-Merier method was used to analyze the overall survival (OS of 2 groups.Results: The efficacy of combined group was superior to single chemotherapy group. The level of vascular endothelial growth factor (VEGF in combined group was obviously lower than that in single chemotherapy group after treatment (P<0.01. Compared with treatment before in combined group, BF, BV and PS decreased while MTT increased after treatment (P<0.05. However, there were no significant differences in single chemotherapygroup before and after treatment (P>0.05. The median OS was 30 months (95%CI: 20.935-39.065 for combined group and 21 months (95%CI: 15.109-26.591 for single chemotherapy group, respectively (P=0.048. The 1-, 2- and 3-year survival rates were 86.2%, 59.3% and 36.6% in combined group, and 70.8%, 32.1% and 17.8% in single chemotherapy group, respectively.Conclusion: Endostar can down-regulate the expression of VEGF, improve the state of hypertransfusion and high permeability of tumor vessels, has better curative effect without slighter adverse reactions, and prolong the survival time of patients with advanced esophageal cancer when combined with chemotherapy.

  5. Clinical Study of Endostar Combined with DP Protocol in Treatment of Advanced Esophageal Cancer

    Institute of Scientific and Technical Information of China (English)

    DENG Wen-ying; LI Ning; LUO Su-xia

    2015-01-01

    Objective: To observe the clinical outcomes of Endostar combined with DP regimen for treating advanced esophageal cancer. Methods: A total of 62 patients with advanced esophageal cancer admitted from May, 2011 to May, 2013 were enrolled for a prospective, randomized controlled trial and 2 cases were excluded from the study because ofⅣ degree of digestive tract reaction and myelosuppression. Therefore, 60 cases could be evaluated, and then divided into combined group (given Endostar+DP plan) and single chemotherapy group, 30 cases in each group. The level of VEGF, tumor size and CT perfusion (CTP) parameters, including blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS) before and after treatment were determined for comparison. Kaplan-Merier method was used to analyze the overall survival (OS) of 2 groups. Results:The efifcacy of combined group was superior to single chemotherapy group. The level of vascular endothelial growth factor (VEGF) in combined group was obviously lower than that in single chemotherapy group after treatment (P0.05). The median OS was 30 months (95%CI: 20.935-39.065) for combined group and 21 months (95%CI: 15.109-26.591) for single chemotherapy group, respectively (P=0.048). The 1-, 2- and 3-year survival rates were 86.2%, 59.3% and 36.6% in combined group, and 70.8%, 32.1% and 17.8% in single chemotherapy group, respectively. Conclusion: Endostar can down-regulate the expression of VEGF, improve the state of hypertransfusion and high permeability of tumor vessels, has better curative effect without slighter adverse reactions, and prolong the survival time of patients with advanced esophageal cancer when combined with chemotherapy.

  6. Affordability Constraints in Major Defense Acquisitions

    Science.gov (United States)

    2016-11-01

    price , this is actually an inverse supply curve. In competitive markets, the inverse supply curve is the firm’s marginal cost curve. When firms have a...support features and functions. The vertical axis represents the unit sale price , inclusive of all life-cycle or total ownership costs as appropriate...Three Defense Programs 3 We can easily extend the example to incorporate cost - plus payment schemes

  7. Sequence analyses reveal that a TPR-DP module, surrounded by recombinable flanking introns, could be at the origin of eukaryotic Hop and Hip TPR-DP domains and prokaryotic GerD proteins.

    Science.gov (United States)

    Hernández Torres, Jorge; Papandreou, Nikolaos; Chomilier, Jacques

    2009-05-01

    The co-chaperone Hop [heat shock protein (HSP) organising protein] is known to bind both Hsp70 and Hsp90. Hop comprises three repeats of a tetratricopeptide repeat (TPR) domain, each consisting of three TPR motifs. The first and last TPR domains are followed by a domain containing several dipeptide (DP) repeats called the DP domain. These analyses suggest that the hop genes result from successive recombination events of an ancestral TPR-DP module. From a hydrophobic cluster analysis of homologous Hop protein sequences derived from gene families, we can postulate that shifts in the open reading frames are at the origin of the present sequences. Moreover, these shifts can be related to the presence or absence of biological function. We propose to extend the family of Hop co-chaperons into the kingdom of bacteria, as several structurally related genes have been identified by hydrophobic cluster analysis. We also provide evidence of common structural characteristics between hop and hip genes, suggesting a shared precursor of ancestral TPR-DP domains.

  8. KARAKTERISASI MALTODEKSTRIN DP 3-9 SERTA KAJIAN POTENSI PENGGUNAANNYA SEBAGAI SUMBER KARBOHIDRAT PADA MINUMAN OLAHRAGA [Characterization of Maltodextrin DP 3-9 and Assesment of Its Potential Application as Carbohydrate Source in Sport Drink

    Directory of Open Access Journals (Sweden)

    Beni Hidayat 1

    2003-04-01

    Full Text Available This research was aimed at characterization of maltodextrin DP 3-9 (produced by enzymatic hydrolysis and membrane separation process as compared to commercial maltodextrin and glucose and assessment of its potential application as carbohydrate source in sport drink. The research showed that application of maltodextrin DP 3-9 had some advantages as compared to glucose with regard to absorption rate that was 2 times longer (60 minutes instead of 30 minutes, osmolality degree that was 5,6 times lower (178 mOsmol/kg as compared to 1000 mOsmol/kg, and relative sweetness degree that was 10 - 11 times lower (6,15-7,20 as compared to 57,00-61,00. However, thie application of maltodekstrin DP 3-9 had limitation which was shown by its viscosity characteristic that was 5,70 -- 6,20% higher (1,29 cSt and 1,37 cSt as compared to 1,22 cSt and 1,29 cSt. When compared to commercial maltodextrin, maltodextrin DP 3-9 is favorable as carbohydrate source in sport drink based on its absorption rate that was more than 2 times faster (60 minutes as compared to more than 120 minutes and storage stability at refrigeration temperature (which was more than 8 weeks, with or without sterilization; with sterilization.

  9. Avian host defense peptides.

    Science.gov (United States)

    Cuperus, Tryntsje; Coorens, Maarten; van Dijk, Albert; Haagsman, Henk P

    2013-11-01

    Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of many organisms. It is becoming increasingly clear that in the animal kingdom the functions of HDPs are not confined to direct antimicrobial actions. Research in mammals has indicated that HDPs have many immunomodulatory functions and are also involved in other physiological processes ranging from development to wound healing. During the past five years our knowledge about avian HDPs has increased considerably. This review addresses our current knowledge on the evolution, regulation and biological functions of HDPs of birds.

  10. A Defense Budget Primer

    Science.gov (United States)

    1998-12-09

    budget practices. See Appendix D for the actual timetable of congressional action on the FY1999 budget.65 See James V. Saturno , The Appropriations...details, see James V. Saturno , The Appropriations Process and the Congressional69 Budget Act, CRS Report 97-947. Table 6. Milestone Votes on the Defense...James V. Saturno , The74 Appropriations Process and the Congressional Budget Act, CRS Report 97-947. The Budget Enforcement Act of 1990 and subsequent

  11. Defensive Minefield Planning

    Science.gov (United States)

    1989-06-01

    Minefield Planning by Carlos Vallejo Game Lieutenant, Ecuadorian Navy B. S., Escuela Superior Naval, Ecuador 1980 Submitted in partial fulfillment of...was a superior open-ocean naval force to the North Koreans, defensive minewarfare was able to, at least temporarily, defeat U.S. Navy objectives in...Oswaldo Rosero 1 Unit 8 Coastal Route 1 Monterey, California 93940 77 11. Office of the N’aval Attache 4 Direccion de Educacion 2535 15th. st. N. W

  12. Plant Defense against Insect Herbivores

    Science.gov (United States)

    Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

    2013-01-01

    Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar. Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight, defense compounds. These bioactive specialized plant defense compounds may repel or intoxicate insects, while defense proteins often interfere with their digestion. Volatiles are released upon herbivory to repel herbivores, attract predators or for communication between leaves or plants, and to induce defense responses. Plants also apply morphological features like waxes, trichomes and latices to make the feeding more difficult for the insects. Extrafloral nectar, food bodies and nesting or refuge sites are produced to accommodate and feed the predators of the herbivores. Meanwhile, herbivorous insects have adapted to resist plant defenses, and in some cases even sequester the compounds and reuse them in their own defense. Both plant defense and insect adaptation involve metabolic costs, so most plant-insect interactions reach a stand-off, where both host and herbivore survive although their development is suboptimal. PMID:23681010

  13. Plant defense against insect herbivores

    DEFF Research Database (Denmark)

    Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

    2013-01-01

    have adapted to resist plant defenses, and in some cases even sequester the compounds and reuse them in their own defense. Both plant defense and insect adaptation involve metabolic costs, so most plant-insect interactions reach a stand-off, where both host and herbivore survive although......Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar....... Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight...

  14. Role of mental retardation-associated dystrophin-gene product Dp71 in excitatory synapse organization, synaptic plasticity and behavioral functions.

    Directory of Open Access Journals (Sweden)

    Fatma Daoud

    Full Text Available BACKGROUND: Duchenne muscular dystrophy (DMD is caused by deficient expression of the cytoskeletal protein, dystrophin. One third of DMD patients also have mental retardation (MR, likely due to mutations preventing expression of dystrophin and other brain products of the DMD gene expressed from distinct internal promoters. Loss of Dp71, the major DMD-gene product in brain, is thought to contribute to the severity of MR; however, the specific function of Dp71 is poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Complementary approaches were used to explore the role of Dp71 in neuronal function and identify mechanisms by which Dp71 loss may impair neuronal and cognitive functions. Besides the normal expression of Dp71 in a subpopulation of astrocytes, we found that a pool of Dp71 colocalizes with synaptic proteins in cultured neurons and is expressed in synaptic subcellular fractions in adult brains. We report that Dp71-associated protein complexes interact with specialized modular scaffolds of proteins that cluster glutamate receptors and organize signaling in postsynaptic densities. We then undertook the first functional examination of the brain and cognitive alterations in the Dp71-null mice. We found that these mice display abnormal synapse organization and maturation in vitro, altered synapse density in the adult brain, enhanced glutamatergic transmission and reduced synaptic plasticity in CA1 hippocampus. Dp71-null mice show selective behavioral disturbances characterized by reduced exploratory and novelty-seeking behavior, mild retention deficits in inhibitory avoidance, and impairments in spatial learning and memory. CONCLUSIONS/SIGNIFICANCE: Results suggest that Dp71 expression in neurons play a regulatory role in glutamatergic synapse organization and function, which provides a new mechanism by which inactivation of Dp71 in association with that of other DMD-gene products may lead to increased severity of MR.

  15. Survey of Small Business Barriers to Department of Defense Contracts

    Science.gov (United States)

    2017-01-01

    2010). The demise of the federal government Small Business Program. Defense Acquisition Research Journal , 17(1), 77–92. Blakey, M. (Ed.). (2011...investigate challenges currently affecting the defense industry base. Factors Affecting Small Business Participation in DoD Contracts We conducted a...accounting standards, export control regulations ( International Traffic in Arms), and a past performance rating on previous government contracts (HASC

  16. Molecular Dynamics Simulations of a Cyclic DP-240 Amylose Fragment in a Periodic Cell: Glass Transition Temperature and Water Diffusion

    Science.gov (United States)

    Molecular dynamics simulations using AMB06C, an in-house carbohydrate force field, (NPT ensembles, 1atm) were carried out on a periodic cell that contained a cyclic-DP-240 amylose fragment and TIP3P water molecules. Molecular conformation and movement of the amylose fragment and water molecules at ...

  17. Experimental evaluation of prefiltering for 56 Gbaud DP-QPSK signal transmission in 75 GHz WDM grid

    DEFF Research Database (Denmark)

    Borkowski, Robert; de Carvalho, Luis Henrique H.; Silva, Edson Porto da

    2014-01-01

    We investigate optical prefiltering for 56Gbaud (224Gbit/s) electrical time-division multiplexed (ETDM) dual polarization (DP) quaternary phase shift keying (QPSK) transmission. Different transmitter-side optical filter shapes are tested and their bandwidths are varied. Comparison of studied filt...

  18. DFT studies of the conformation and relative energies of alpha-maltotetraose (DP-4): An amylose fragment at atomic resolution

    Science.gov (United States)

    DFT optimization studies of more than one hundred conformations of a-maltotetraose have been carried out at the B3LYP/6-311++G** level of theory. The DP-4 fragments of predominately 4C1 chair residues include tightly bent forms, helix, band-flips, kinks, boat, and some 1C4 conformers. The three do...

  19. Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallization.

    Science.gov (United States)

    Wagner, Leona; Wermann, Michael; Rosche, Fred; Rahfeld, Jens-Ulrich; Hoffmann, Torsten; Demuth, Hans-Ulrich

    2011-07-01

    Abstract In the present studies we resolved the post-translational microheterogeneity of purified porcine dipeptidyl peptidase IV (DP 4) from kidney cortex. Applying SDS-homogeneous DP 4 onto an analytical agarose isoelectric focusing (IEF) gel, pH 4-6, activity staining resulted in at least 17 isoforms between pH 4.8-6.0. These could be separated into fractions with only two to six isoforms by means of preparative liquid-phase IEF, using a Rotofor cell. Starting off with three parallel Rotofor runs under the same conditions at pH 5-6, the fractions were pooled according to the specific activity of DP 4, pH and analytical IEF profile, and further refractionated without any additional ampholytes. Since excessive dilution of ampholytes and proteins was kept to the minimum, a second refractionation step could be introduced, resulting in pH gradients between 0.022 and 0.028 pH increments per fraction. By performing two consecutive refractionation steps, the high resolution necessary for the separation of DP 4 isoforms could be achieved. This represents an alternative method if isolation of isoforms with similar pI's results in precipitation and denaturation in presence of a narrow pH range. Furthermore, it demonstrates that preparative IEF is a powerful tool to resolve post-translational microheterogeneity of a purified protein required for crystallization processing.

  20. The long-term behaviour of the herbicides chloridazon and 2,4-DP-P after application according to good agricultural practice in two different soils of the Federal Republic of Germany. Das Langzeitverhalten der Herbizidwirkstoffe Chloridazon und 2,4-DP-P nach Praxisanwendung in zwei verschiedenen Boeden der Bundesrepublik Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Gatzweiler, E.

    1994-04-01

    The long-term behaviour of the herbicides [4,5-[sup 14]C]chloridazon and [phenyl-U-[sup 14]C]2,4-DP-P was studied in lysimeters (profile depth 1.1 m) with a degraded loess soil (Parabraunerde - CH1 and DP1) and a pseudogley brown soil (Pseudogley-Braunerde - CH2 and DP2) over a two years period under field conditions. Chloridazon was applied by preemergence to sugar beets and 2,4-DP-P by postemergence to spring wheat. The crop husbandry was conducted in accordance with good agricultural practice in both crop rotations of sugar beets-winter wheat-winter barley (chloridazon for CH1 and CH2) and spring wheat-winter barley-winter rape (2,4-DP-P for DP1 and DP2). In addition, the degradation, metabolization and mineralization of the active ingredients (chloridazon for CH3 and CH4; 2,4-DP-P for DP3 and DP4) were studied in standardized experiments with both soils. Due to its particular significance as a chloridazon degradation product, [4,5-[sup 14]C]metabolite B was observed in an 80-day degradation study (MB1, MB2+S and MB2-S) exclusively in the degraded loess soil. (orig./UHE)

  1. Defense Coastal/Estuarine Research Program (DCERP)

    Science.gov (United States)

    2007-09-19

    compensation point model include measures of wind speed, relative humidity, solar radiation, temperature, and leaf apoplast chemistry (Sutton et al...Supporting Researcher(s) and Staff: Ignacio Moore (Virginia Tech); 1 post-doctoral researcher Hypotheses: 1. Stress hormone levels of target bird...velocity, barometric pressure, humidity, solar radiation, SEDIMENTOLOGY Texture and composition, sediment compaction and distribution of hard bottom

  2. The Soviet Civil Defense Medical Preparedness Program.

    Science.gov (United States)

    1984-03-01

    emergency ambulance service staffed by physicians. In addition, there is a network of hygiene- epidemological stations with their own physicians. In the... Epidemological Stations (SES) at republic, oblast, and city levels and also at institutes of epidemiology, microbiology, and hygiene. The mission of these... epidemological control in host areas and in shelters. o Planning for and preparation of the evacuation of urban CDMS formations and health institutions, their

  3. Defense Acquisition University Program Managers Tool Kit

    Science.gov (United States)

    2011-01-01

    Agreement EMD—Engineering & Manufacturing Development IEP —Information Exchange Project S&E—Science and Engineering Cooperative Production Coproduction...Licensed Production Production Sharing Foreign Military Sales Technology Opportunities and User Capability Needs NATO Forums DEAs/ IEPs Staff

  4. Defense Switched Network Technology and Experiments Program.

    Science.gov (United States)

    2014-09-26

    3) development and test of data communication techniques using DoD-standard data protocols in an integrated voice /data network, and (4) EISN system... communication techniques using DoD-standard data protocols in an integrated voice /data network, and (4) EISN system coordination and experiment planning...control voice trunks that use E&M signaling and go from the RCP switch to the PCI or to another RCP switch; (e) A Dual- Tone Multiple-Frequency (DTMF

  5. Defense Logistics Agency’s Warstopper Program

    Science.gov (United States)

    2007-08-15

    Support ($11.7 million), and Construction and Equipment ($3.3 million) contracts. We did not examine Warstopper funding related to contracts for...protection barrier consisting of a prefabricated, multicellular system made of a welded steel-wire mesh, heavily galvanized, with a nonwoven geotextile...chamber. DLA decided to fund the construction of an additional Nesatron chamber with the option to sell it to the contractor at fair market value at

  6. Defense Standardization Program Status of Standardization Projects

    Science.gov (United States)

    1993-09-30

    TOP AER MB DO F2 A 923 933 941 A MD MS 03 MS U 6505 5828 A-A-XXX WATER FOR IRRIGATION MB DM F4 A 931 941 941 A MU MS 03 N 6505 5830 A-A-XXX THROMBIN...941 941 A MD MS 03 N6515 5572 A-A-XXX HAMMEL REFLEX TEST MB ON H5 A 931 941 933 G MD MS 03 U6515 5573 A-A-XXX SYRINGE IRRIGATING MB ON F4 A 931 941 933...ELEVATOR, DENTAL MB DM F4 A 903 913 934 Y MD MS 03 U C 6520 2102 A-A-XXX STOP ENDODONTIC ME DM F4 A 892 902 934 Y MD MS 03 U B 6520 2109 A-A-XXX

  7. Future Years Defense Program (FYDP) Structure

    Science.gov (United States)

    2004-04-01

    methods. Develop improved functional food service systems for all of DOD to include storage, refrigeration, preparation, serving, waste disposal, and... functional food service systems to include storage (refrigerated and dry), transportation conditions, serving, sanitation (waste disposal) equipment

  8. Defense Acquisitions. Assessments of Selected Weapon Programs

    Science.gov (United States)

    2007-03-01

    countermeasure dispenser capable of loading and employing expendables, such as flares, chaff, and smoke . S Page 39ource: BAE Systems.System development...not collecting statistical data for them. As reported in our last assesment , we expect that the prime contract could overrun its target cost by

  9. Benefits of the Defense Standardization Program

    Science.gov (United States)

    1991-09-01

    motor scooters , and bicycles 24GP Tractors 2410 Tractors, full-track, low-speed 2420 Tractors, wheeled 2430 Tractors, track-laying, high-speed 25GP... suspension and the self-deflating, and self-inflating capability of the Air Force tires when the vehicle switches from on-road to off-road and back...road to off-road and back again, and independent suspension . C-4 Using the purchase description, NAVFAC issued an invitation for bids and has awarded

  10. Improving Defense Health Program Medical Research Processes

    Science.gov (United States)

    2017-08-08

    Health (NIH), Centers for Disease Control and Prevention , private foundations, and others (Figure 1b). These disparate funding sources may fund...Reed and his team’s discovery and confirmation of the transmission of deadly diseases such as typhoid fever and yellow fever. 5 Researchers also...contributed to the development of intravenous therapy for cholera ; 6 and the development of anti- malarial agents such as chloroquine, doxycycline

  11. Defense Nanotechnology Research and Development Programs

    Science.gov (United States)

    2005-05-17

    that can be dyed to match specific patterns and woven into uniforms. • An electrospun fiberized adhesive has been developed for fabric laminates...150 by 30 crossbars ). • High moment, magnetic nano-tags have been fabricated that allow DNA fingerprinting without DNA amplification (i.e., the... learned , and DoD guidance is critical to assure both the optimum direction of ongoing research efforts and the optimum leveraging of this knowledge to

  12. Assessment of Accelerated Acquisition of Defense Programs

    Science.gov (United States)

    2016-09-01

    acquisition, and fielding of state-of-the- art capabilities in the force. ix Table of Contents 1. Introduction...with a state-of-the- art communications backbone to enable exchange of information (voice, data, and video) at high speeds with high reliability...the basic and extended range JASSMs (4987 missiles, 1900 of which had been delivered) 57 Degree of urgency: Previous efforts to develop such a

  13. DP97, a DEAD box DNA/RNA helicase, is a target gene-selective co-regulator of the constitutive androstane receptor

    Energy Technology Data Exchange (ETDEWEB)

    Kanno, Yuichiro, E-mail: ykanno@phar.toho-u.ac.jp [Faculty of Pharmaceutical Sciences, Toho University, Chiba (Japan); Serikawa, Takafumi; Inajima, Jun; Inouye, Yoshio [Faculty of Pharmaceutical Sciences, Toho University, Chiba (Japan)

    2012-09-14

    Highlights: Black-Right-Pointing-Pointer DP97 interacts with nuclear receptor CAR. Black-Right-Pointing-Pointer DP97 enhances CAR-mediated transcriptional activation. Black-Right-Pointing-Pointer DP97 synergistically enhances transactivity of CAR by the co-expression of SRC-1 or PGC1{alpha}. Black-Right-Pointing-Pointer DP97 is a gene-selective co-activator for hCAR. -- Abstract: The constitutive androstane receptor (CAR) plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters. In this study, we demonstrated that DP97, a member of the DEAD box DNA/RNA helicase protein family, is a novel CAR-interacting protein. Using HepG2 cells expressing human CAR in the presence of tetracycline, we showed that knockdown of DP97 with small interfering RNAs suppressed tetracycline-inducible mRNA expression of CYP2B6 and UGT1A1 but not CYP3A4. Thus, DP97 was found to be a gene (or promoter)-selective co-activator for hCAR. DP97-mediated CAR transactivation was synergistically enhanced by the co-expression of SRC-1 or PGC1{alpha}, therefore it might act as mediator between hCAR and appropriate co-activators.

  14. Thermal conductivity of the cryoprotective cocktail DP6 in cryogenic temperatures, in the presence and absence of synthetic ice modulators.

    Science.gov (United States)

    Ehrlich, Lili E; Malen, Jonathan A; Rabin, Yoed

    2016-10-01

    The thermal conductivity of the cryoprotective agent (CPA) cocktail DP6 in combination with synthetic ice modulators (SIMs) is measured in this study, using a transient hot-wire method. DP6 is a mixture of 3 M dimethyl sulfoxide (DMSO) and 3 M propylene glycol, which received significant attention in the cryobiology community in recent years. Tested SIMs include 6% 1,3Cyclohexanediol, 6% 2,3Butanediol, and 12% PEG400 (percentage by volume). This study integrates the scanning cryomacroscope for visual verification of crystallization and vitrification events. It is demonstrated that the thermal conductivity of the vitrifying CPA cocktail decreases monotonically with the decreasing temperature down to -180 °C. By contrast, the thermal conductivity of the crystalline material increases with decreasing temperature in the same temperature range. Results of this study demonstrate that the thermal conductivity may vary by three fold between the amorphous and crystalline phases of DP6 below the glass transition temperature of DP6 (Tg = -119 °C). The selected SIMs demonstrate the ability to inhibit crystallization in DP6, even at subcritical cooling rates. An additional ice suppression capability is observed by the Euro-Collins as a vehicle solution, disproportionate to its volume ratio in the cocktail. The implication of the observed thermal conductivity differences between the amorphous and crystalline phases of the same cocktail on cryopreservation simulations is significant in some cases and must be taken into account in thermal analyses of cryopreservation protocols.

  15. Defense Acquisitions: How DOD Acquires Weapon Systems and Recent Efforts to Reform the Process

    Science.gov (United States)

    2013-01-02

    Weapon Systems and Recent Efforts to Reform the Process 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT ...oversee and mange acquisition programs. At each milestone, a program must meet specific statutory and regulatory requirements before the program can...the FY2007 defense authorization bill stated Simply put, the Department of Defense (DOD) acquisition process is broken. The ability of the

  16. Experimental investigation on electroplastic effect of DP980 advanced high strength steel

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Huanyang [School of Materials Science and Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, 200030 Shanghai (China); Dong, Xianghuai, E-mail: dongxh@sjtu.edu.cn [School of Materials Science and Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, 200030 Shanghai (China); Liu, Kai; Ai, Zhenqiu; Peng, Fang; Wang, Qian [School of Materials Science and Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, 200030 Shanghai (China); Chen, Fei [Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham, NG7 2RD Nottingham (United Kingdom); Wang, Jianfeng [General Motor China Science Lab, No. 56 Jinwan Road, 201206 Shanghai (China)

    2015-06-18

    This paper investigated the influence of the electric pulses on the flow behavior and plasticity of the advanced high strength steel (AHSS) Dual Phase, DP980. In order to isolate the thermal effect of the electric pulses, two kinds of uniaxial tensile tests at the same testing temperature were carried out: (1) isothermal tensile test carried out in an environment cabinet and (2) electrically-assisted isothermal tensile test. The stress–strain curves were recorded and compared. The results indicate that at the same testing temperature, the stress–strain curves obtained by test (1) are generally lower than curves deserved by test (2). It demonstrates that electric pulses can not reduce the flow stress when compared with the case that without electric pulse which is contrary to the traditional electroplastic effect. Another result is that when the testing temperature is not more than 573 K, the stress–strain curves obtained by both tests are higher than the tension curve in room temperature and the cases are opposite when testing temperature is more than 573 K. In addition, the elongation improvement is not observed as well in the stress–strain curves. The difference between the two tests when compared the cross section shrinkage rate and the fracture elongation rate is not obvious. From another aspect to study the athermal effect of the electric pulse, tests with only varying the peak current density or pulse frequency at the same testing temperature were conducted. The results once again show that no evident difference between the stress–strain curves. It confirms that no athermal effect exists in DP980. However, with temperature elevated to 473 K, the material is strengthened and then weakened as temperature exceeds 473 K. Scanning electron microscope (SEM) analysis was adopted to better understand the observed phenomena. The results show that the decomposion of the martensite and the thermal effect are the main reason that attributes to the strength

  17. Synthetic Plant Defense Elicitors

    Directory of Open Access Journals (Sweden)

    Yasemin eBektas

    2015-01-01

    Full Text Available To defend themselves against invading pathogens plants utilize a complex regulatory network that coordinates extensive transcriptional and metabolic reprogramming. Although many of the key players of this immunity-associated network are known, the details of its topology and dynamics are still poorly understood. As an alternative to forward and reverse genetic studies, chemical genetics-related approaches based on bioactive small molecules have gained substantial popularity in the analysis of biological pathways and networks. Use of such molecular probes can allow researchers to access biological space that was previously inaccessible to genetic analyses due to gene redundancy or lethality of mutations. Synthetic elicitors are small drug like molecules that induce plant defense responses, but are distinct from known natural elicitors of plant immunity. While the discovery of the some synthetic elicitors had already been reported in the 1970s, recent breakthroughs in combinatorial chemical synthesis now allow for inexpensive high-throughput screens for bioactive plant defense-inducing compounds. Along with powerful reverse genetics tools and resources available for model plants and crop systems, comprehensive collections of new synthetic elicitors will likely allow plant scientists to study the intricacies of plant defense signaling pathways and networks in an unparalleled fashion. As synthetic elicitors can protect crops from diseases, without the need to be directly toxic for pathogenic organisms, they may also serve as promising alternatives to conventional biocidal pesticides, which often are harmful for the environment, farmers and consumers. Here we are discussing various types of synthetic elicitors that have been used for studies on the plant immune system, their modes-of-action as well as their application in crop protection.

  18. Nanomaterials for Defense Applications

    Science.gov (United States)

    Turaga, Uday; Singh, Vinitkumar; Lalagiri, Muralidhar; Kiekens, Paul; Ramkumar, Seshadri S.

    Nanotechnology has found a number of applications in electronics and healthcare. Within the textile field, applications of nanotechnology have been limited to filters, protective liners for chemical and biological clothing and nanocoatings. This chapter presents an overview of the applications of nanomaterials such as nanofibers and nanoparticles that are of use to military and industrial sectors. An effort has been made to categorize nanofibers based on the method of production. This chapter particularly focuses on a few latest developments that have taken place with regard to the application of nanomaterials such as metal oxides in the defense arena.

  19. Phenomenon of Psychological Defense

    Directory of Open Access Journals (Sweden)

    Elena T. Sokolova

    2011-01-01

    Full Text Available The author discusses the controversial issues of formation and functioning of psy¬chological defense mechanisms in ontogenesis and in personality disorders as they are represented in classical and contemporary psychoanalysis, in cognitivism and communication theory. The paper emphasizes the role of cognitive organi¬zation (style, sign-symbolic mediation, representative system of object relations and attachments in individual typological variability of the level organization of ciency of personal and social adaptation, in maturity and mental health of personality

  20. 76 FR 65186 - Request for Public Comments on How the Department of Defense Can Improve the Way It Procures...

    Science.gov (United States)

    2011-10-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Request for Public Comments on How the Department of Defense Can Improve the Way It Procures Defense Items... program is an important instrument of U.S foreign policy. It allows the United States to provide...

  1. Defensive engagement and perceptual enhancement

    OpenAIRE

    Keil, Andreas; Bradley, Margaret M; Ihssen, Niklas; Heim, Sabine; Vila, Jaime; Guerra, Pedro; Lang, Peter J.

    2010-01-01

    We tested whether visual cortical sensitivity to external cues in the context of an acute defensive reaction is heightened or attenuated. A strong cardiac defense (fear) response was elicited by presenting an abrupt, loud acoustic stimulus following a 10-minute period of quiescence. Electrocortical responses to aversive and neutral pictures following defensive stimulus onset were measured using dense-array EEG. Pictures were flickered at 12.5 Hz to evoke steady-state visual evoked potentials ...

  2. Ballistic Missile Defense System (BMDS)

    Science.gov (United States)

    2015-12-01

    Estimate RDT&E - Research , Development, Test, and Evaluation SAR - Selected Acquisition Report SCP - Service Cost Position TBD - To Be Determined TY - Then...all ranges and in all phases of flight. Following guidance from the President, the Secretary of Defense approved the Ballistic Missile Defense (BMD...based Midcourse Defense (GMD) system to enhance our capability against Intercontinental Ballistic Missiles. We are currently sustaining 30

  3. Experimental and Numerical Simulations of Phase Transformations Occurring During Continuous Annealing of DP Steel Strips

    Science.gov (United States)

    Wrożyna, Andrzej; Pernach, Monika; Kuziak, Roman; Pietrzyk, Maciej

    2016-04-01

    Due to their exceptional strength properties combined with good workability the Advanced High-Strength Steels (AHSS) are commonly used in automotive industry. Manufacturing of these steels is a complex process which requires precise control of technological parameters during thermo-mechanical treatment. Design of these processes can be significantly improved by the numerical models of phase transformations. Evaluation of predictive capabilities of models, as far as their applicability in simulation of thermal cycles thermal cycles for AHSS is considered, was the objective of the paper. Two models were considered. The former was upgrade of the JMAK equation while the latter was an upgrade of the Leblond model. The models can be applied to any AHSS though the examples quoted in the paper refer to the Dual Phase (DP) steel. Three series of experimental simulations were performed. The first included various thermal cycles going beyond limitations of the continuous annealing lines. The objective was to validate models behavior in more complex cooling conditions. The second set of tests included experimental simulations of the thermal cycle characteristic for the continuous annealing lines. Capability of the models to describe properly phase transformations in this process was evaluated. The third set included data from the industrial continuous annealing line. Validation and verification of models confirmed their good predictive capabilities. Since it does not require application of the additivity rule, the upgrade of the Leblond model was selected as the better one for simulation of industrial processes in AHSS production.

  4. Thermal expansion of vitrified blood vessels permeated with DP6 and synthetic ice modulators.

    Science.gov (United States)

    Eisenberg, David P; Taylor, Michael J; Jimenez-Rios, Jorge L; Rabin, Yoed

    2014-06-01

    This study provides thermal expansion data for blood vessels permeated with the cryoprotective cocktail DP6, when combined with selected synthetic ice modulators (SIMs): 12% polyethylene glycol 400, 6% 1,3-cyclohexanediol, and 6% 2,3-butanediol. The general classification of SIMs includes molecules that modulate ice nucleation and growth, or possess properties of stabilizing the amorphous state, by virtue of their chemical structure and at concentrations that are not explained on a purely colligative basis. The current study is part of an ongoing effort to characterize thermo-mechanical effects on structural integrity of cryopreserved materials, where thermal expansion is the driving mechanism to thermo-mechanical stress. This study focuses on the lower part of the cryogenic temperature range, where the cryoprotective agent (CPA) behaves as a solid for all practical applications. By combining results obtained in the current study with literature data on the thermal expansion in the upper part of the cryogenic temperature range, unified thermal expansion curves are presented.

  5. Microstructure and Hardness Profiles of Bifocal Laser-Welded DP-HSLA Steel Overlap Joints

    Science.gov (United States)

    Grajcar, A.; Matter, P.; Stano, S.; Wilk, Z.; Różański, M.

    2017-04-01

    The article presents results related to the bifocal laser welding of overlap joints made of HSLA and DP high-strength steels. The joints were made using a disk laser and a head enabling the 50-50% distribution of laser power. The effects of the laser welding rates and the distance between laser spots on morphological features and hardness profiles were analyzed. It was established that the positioning of beams at angles of 0° or 90° determined the hardness of the individual zones of the joints, without causing significant differences in microstructures of the steels. Microstructural features were inspected using scanning electron microscopy. Both steels revealed primarily martensitic-bainitic microstructures in the fusion zone and in the heat-affected zone. Mixed multiphase microstructures were revealed in the inter-critical heat-affected zone of the joint. The research involved the determination of parameters making it possible to reduce the hardness of joints and prevent the formation of the soft zone in the dual-phase steel.

  6. Effect of process parameters on optimum welding condition of DP590 steel by friction stir welding

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Gon; Kim, Ji Sun; Kim, In Ju [Korea Institute of Industrial Technology, Gwangju (Korea, Republic of)

    2014-12-15

    In the automotive industry, vehicle weight reduction techniques have been actively studied to improve the rate of fuel consumption and to cope with the regulation restricting exhaust gas. For this reason, advanced high-strength steel (AHSS) is preferred in the automobile industry as its tensile strength is 590 MPa and over. In this study, to obtain the optimum welding condition, the friction stir welding (FSW) process applied to AHSS was considered. The FSW experiment was performed on a stir plate using a Si{sub 3}N{sub 4} tool and a 1.4-mm thick DP590 steel sheet manufactured by cold rolling. In addition, to investigate the temperature distribution of the advancing and retreating sides in the welding state, the tool rotation speed of 800 rpm, and the welding speed of 180 mm/min, a K-type thermocouple was inserted in the backing plate, and the peak temperature was evaluated at each point. Especially, the correlation between the heat input per unit length and the formation of the FSW zone was minutely analyzed.

  7. Joint strength in high speed friction stir spot welded DP 980 steel

    Energy Technology Data Exchange (ETDEWEB)

    Saunders, Nathan; Miles, Michael; Hartman, Trent; Hovanski, Yuri; Hong, Sung Tae; Steel, Russell

    2014-05-01

    High speed friction stir spot welding was applied to 1.2 mm thick DP 980 steel sheets under different welding conditions, using PCBN tools. The range of vertical feed rates used during welding was 2.5 mm – 102 mm per minute, while the range of spindle speeds was 2500 – 6000 rpm. Extended testing was carried out for five different sets of welding conditions, until tool failure. These welding conditions resulted in vertical welding loads of 3.6 – 8.2 kN and lap shear tension failure loads of 8.9 – 11.1 kN. PCBN tools were shown, in the best case, to provide lap shear tension fracture loads at or above 9 kN for 900 spot welds, after which tool failure caused a rapid drop in joint strength. Joint strength was shown to be strongly correlated to bond area, which was measured from weld cross sections. Failure modes of the tested joints were a function of bond area and softening that occurred in the heat-affected zone.

  8. Developing the (d,p γ) reaction as a surrogate for (n, γ) in inverse kinematics

    Science.gov (United States)

    Lepailleur, Alexandre; Baugher, Travis; Cizewski, Jolie; Ratkiewicz, Andrew; Walter, David; Pain, Steven; Smith, Karl; Garland, Heather; Goddess Collaboration

    2016-09-01

    The r-process that proceeds via (n, γ) reactions on neutron-rich nuclei is responsible for the synthesis of about half of the elements heavier than iron. Because (n, γ) measurements on short-lived isotopes are not possible, the (d,p γ) reaction is being investigated as a surrogate for (n, γ). Of particular importance is validating a surrogate in inverse kinematics. Therefore, the 95Mo(d,p γ) reaction was measured in inverse kinematics with stable beams from ATLAS and CD2 targets. Reaction protons were measured in coincidence with gamma rays with GODDESS - Gammasphere ORRUBA: Dual Detectors for Experimental Structure Studies. The Oak Ridge Rutgers University Barrel Array (ORRUBA) of position-sensitive silicon strip detectors was augmented with annular arrays of segmented strip detectors at backward and forward angles, resulting in a high-angular coverage for light ejectiles. Preliminary results from the 95Mo(d,p γ) study will be presented. This work was supported in part by the U.S. Department of Energy and National Science Foundation.

  9. AZ31镁合金与DP980高强钢的纯电塑性效应实验研究%Study on Pure Electroplastic Effect of AZ31 Alloy and DP980 AHSS

    Institute of Scientific and Technical Information of China (English)

    霭振球; 闫磊; 董湘怀

    2015-01-01

    通过单向拉伸试验研究了AZ31镁合金和DP980高强钢两种轻型材料的电塑性效应,研究表明:AZ31镁合金存在纯电塑性效应,而DP980高强钢不存在明显的纯电塑性效应.通过分析峰值电流密度和频率对AZ31镁合金流动应力的影响规律,在Fields-Backofen模型基础上建立了考虑电塑性效应的流动应力方程,此方程能很好的拟合小变形阶段的流变行为.

  10. Development of DP (Dynamic Positioning) to pull-in sub sea pipelines; Utilizacao de barcos de manuseio de ancoras operando com DP (Dynamic Positioning) para arraste de dutos submarinos

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Manoel H.S. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil); Galgoul, Elton C. [Suporte Engenharia, Luziania, GO (Brazil)

    2004-07-01

    Sub sea pipeline construction at oil and gas fields, with high concentration of on-bottom facilities, becomes more difficult when mooring operations and pipeline approach to a congested platform have to be performed. One method that has often been applied in Brazil is the so-called 'DP (Dynamic Positioning) pull-in', where PETROBRAS owned pipelay Barge, BGL-1, is moored away from the congested area, while a DP anchor handler pulls the rigid pipeline from BGL-1 to a target near the platform. The method was conceived to avoid mooring operations near the congested platforms as well as to minimize risks due to the pipeline initiation process. Inside the congested area the initiation with aid of a 'dead-man' anchor on the sea bottom, which would be a more conventional solution, becomes impossible in most cases. This paper will discuss the engineering work required to perform the 'DP pull-in' as well as show the operational steps, from the start-up to the final abandonment of the pipeline initiation head inside the target area. (author)

  11. Comparing Properties of Adhesive Bonding, Resistance Spot Welding, and Adhesive Weld Bonding of Coated and Uncoated DP 600 Steel%Comparing Properties of Adhesive Bonding, Resistance Spot Welding, and Adhesive Weld Bonding of Coated and Uncoated DP 600 Steel

    Institute of Scientific and Technical Information of China (English)

    Fatih Hayat

    2011-01-01

    Zinc coated dual phase 600 steel (DP 600 grade) was investigated, utilisation of which has gradually increased with each passing day in the automotive industry. The adhesive bonding (AB), resistance spot welding (RSW), and adhesive weld bonding (AWB) ioints of the zinc coated DP 600 steel were investigated. Additionally, the zinc coating was removed using HCL acid in order to investigate the effect of the coating. The microstructure, tensile shear strengths, and fracture properties of adhesive bonding (AB), resistance spot welding (RSW), and adhesive weld bonding (AWB) joints of the coated and uncoated DP 600 steel were compared. In addition, a mechani cal-electrical-thermal coupled model in a finite element analysis environment was utilised. The thermal profile phe nomenon was calculated by simulating this process. The results of the tensile shear test indicated that the tensile load bearing capacity (TLBC) values of the coated specimens among the three welding methods were higher than those of the uncoated specimens. Additionally, the tensile strength of the AWB joints of the coated and uncoated specimens was higher than that of the AB and RSW joints. It was determined that the fracture behaviours and the deformation caused were different for the three welding methods.

  12. Development of DP (Dynamic Positioning) to pull-in sub sea pipelines; Utilizacao de barcos de manuseio de ancoras operando com DP (Dynamic Positioning) para arraste de dutos submarinos

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Manoel H.S. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil); Galgoul, Elton C. [Suporte Engenharia, Luziania, GO (Brazil)

    2004-07-01

    Sub sea pipeline construction at oil and gas fields, with high concentration of on-bottom facilities, becomes more difficult when mooring operations and pipeline approach to a congested platform have to be performed. One method that has often been applied in Brazil is the so-called 'DP (Dynamic Positioning) pull-in', where PETROBRAS owned pipelay Barge, BGL-1, is moored away from the congested area, while a DP anchor handler pulls the rigid pipeline from BGL-1 to a target near the platform. The method was conceived to avoid mooring operations near the congested platforms as well as to minimize risks due to the pipeline initiation process. Inside the congested area the initiation with aid of a 'dead-man' anchor on the sea bottom, which would be a more conventional solution, becomes impossible in most cases. This paper will discuss the engineering work required to perform the 'DP pull-in' as well as show the operational steps, from the start-up to the final abandonment of the pipeline initiation head inside the target area. (author)

  13. Performance of the Defense Acquisition System, 2015 Annual report

    Science.gov (United States)

    2015-09-16

    performance measure has its strengths and weaknesses , so we use multiple measures (e.g., at both the program and contract level) and subsequent analysis to...could have led to program success or problems. Defense acquisition is complex, and each measure has its strengths and weaknesses , so attributing...Program Contract Costs Related to Targets Proportions of (Non-FFP) Contracts At or Below Cost Targets for Currently Active MDAPs (controlling for

  14. JPRS Report Central Eurasia Military Affairs Defense Industry and Conversion

    Science.gov (United States)

    2007-11-02

    and organizing complex, ecologi - high interest among defense workers. But let us begin cally clean production operations. The state conversion with...51%, in 1991 it was reduced Ecology " program. These programs will be carried out by to 44% and, based upon 1992’s results, this share will hundreds of...PO "More", Feodosiya Passenger hydrofoil motor ships 7. Program for producing equipment for the "Almaz" Plant, Kiev Equipment for creating plants for

  15. Microstructure and mechanical properties of a medium-carbon bainitic steel by a novel quenching and dynamic partitioning (Q-DP) process

    Energy Technology Data Exchange (ETDEWEB)

    Li, Qiangguo; Huang, Xuefei; Huang, Weigang, E-mail: huangwg56@163.com

    2016-04-26

    A novel Quenching and Dynamic Partitioning (Q-DP) process for a 0.3C-1.4Si-1.8Mn-1.3Cr-0.3Mo (wt%) bainitic steel was developed and the microstructure and mechanical properties were investigated. The results show that the microstructure of the Q-DP treated steel consists of bainite, martensite and retained austenite, and it exhibit a better combination of tensile strength (above 1500 MPa), total elongation (above 17%) and impact toughness (above 90 J). Among the different Q-DP process, the sample treated by 250 °C Q-DP process exhibits the best combination of strength (1519 MPa), ductility (21.3%), the product of strength and elongation (PSE, 32.4 GPa%) and maximum impact toughness (108 J) compared to the quenching and partitioning (Q&P) process and other Q-DP processes. In addition, the work hardening behaviors of the Q&P and Q-DP samples were investigated. The stress-strain curves show that the Q&P and 250 °C Q-DP treated samples exhibit the larger uniform elongation and the value of n calculated for samples is 0.109 and 0.101 respectively.

  16. European Missile Defense and Russia

    Science.gov (United States)

    2014-07-01

    most senior level—the only one that matters in Russian decisionmaking cul - ture—is also of significance today and will also be re- ferred to later in... org /missile-defense/us-ballistic-missile-defense/p30607. 9. Email exchange with author, July 2013. 10. “Safeguard,” Washington, DC: Federation of Ameri

  17. Measurement of the Cross Section and Analyzing Powers for d+p Elastic Scattering at 180 MeV

    Science.gov (United States)

    Bailey, C. D.; Stephenson, E. J.; Bacher, A. D.; Micherdzinska, A. M.; Messchendorp, J. G.; Biegun, A.; Eslami-Kalantari, M.; Joulaeizadeh, L.; Kalantar-Nayestanaki, N.; Mardanpour, H.; Moeini, H.; Ramazani-Moghaddam-Arani, A.; Shende, S. V.; Wörtche, H.; Stephan, E.; Kistryn, St.; Sekiguchi, K.

    2008-04-01

    We have measured cross sections and analyzing powers for various d+d reaction channels, including d+d elastic and d+d->p+t at 130 MeV and 180 MeV, with the hope of providing a testing ground for new 4-body theoretical predictions. These data were collected at the KVI cyclotron (Groningen) using the Big Bite spectrometer and a polarized deuteron beam. In addition to the d+d channels, we also measured the cross section and analyzing powers (Ay and Ayy) for d+p elastic scattering at the same energies for comparison with existing data and with 3-body calculations (with and without three nucleon forces). We report here our results for the d+p elastic data at 180 MeV. The analysis procedure will be reviewed and several preliminary results will be shown.

  18. Sensitivity of (d,p) reactions to high n-p momenta and the consequences for nuclear spectroscopy studies

    CERN Document Server

    Bailey, G W; Tostevin, J A

    2016-01-01

    Theoretical models of low-energy (d,p) single-neutron transfer reactions are a crucial link between experimentation, nuclear structure and nuclear astrophysical studies. Whereas reaction models that use local optical potentials are insensitive to short-range physics in the deuteron, we show that including the inherent nonlocality of the nucleon-target interactions and realistic deuteron wave functions generates significant sensitivity to high n-p relative momenta and to the underlying nucleon-nucleon interaction. We quantify this effect upon the deuteron channel distorting potentials within the framework of the adiabatic deuteron breakup model. The implications for calculated (d,p) cross sections and spectroscopic information deduced from experiments are discussed.

  19. Profibus DP从站冗余技术及其实现%Profibus DP slave redundancy technology and its implementation

    Institute of Scientific and Technical Information of China (English)

    刘长龙

    2011-01-01

    针对市场上对高可靠性Profibus DP控制系统需求,研究了相关国际标准,采用SPC3链路层控制器作为核心芯片,进行软硬件协同设计,开发出符合PNO标准<Specification Slave Redundancy V1.2>要求的从站冗余协议栈.%Aim to the requirement for high reliable Profibus DP control system in the market, this paper research on relative international standards, adopt SPC3 link layer controller as core chip, make sofeware and hardware co-design, and finally develop a new DP slave redundancy protocol stack which meets the .

  20. Detection of Ketones by a Novel Technology: Dipolar Proton Transfer Reaction Mass Spectrometry (DP-PTR-MS)

    Science.gov (United States)

    Pan, Yue; Zhang, Qiangling; Zhou, Wenzhao; Zou, Xue; Wang, Hongmei; Huang, Chaoqun; Shen, Chengyin; Chu, Yannan

    2017-05-01

    Proton transfer reaction mass spectrometry (PTR-MS) has played an important role in the field of real-time monitoring of trace volatile organic compounds (VOCs) due to its advantages such as low limit of detection (LOD) and fast time response. Recently, a new technology of proton extraction reaction mass spectrometry (PER-MS) with negative ions OH- as the reagent ions has also been presented, which can be applied to the detection of VOCs and even inorganic compounds. In this work, we combined the functions of PTR-MS and PER-MS in one instrument, thereby developing a novel technology called dipolar proton transfer reaction mass spectrometry (DP-PTR-MS). The selection of PTR-MS mode and PER-MS mode was achieved in DP-PTR-MS using only water vapor in the ion source and switching the polarity. In this experiment, ketones (denoted by M) were selected as analytes. The ketone (molecular weight denoted by m) was ionized as protonated ketone [M + H]+ [mass-to-charge ratio ( m/z) m + 1] in PTR-MS mode and deprotonated ketone [M - H]- ( m/z m - 1) in PER-MS mode. By comparing the m/z value of the product ions in the two modes, the molecular weight of the ketone can be positively identified as m. Results showed that whether it is a single ketone sample or a mixed sample of eight kinds of ketones, the molecular weights can be detected with DP-PTR-MS. The newly developed DP-PTR-MS not only maintains the original advantages of PTR-MS and PER-MS in sensitive and rapid detection of ketones, but also can estimate molecular weight of ketones.

  1. Detection of Ketones by a Novel Technology: Dipolar Proton Transfer Reaction Mass Spectrometry (DP-PTR-MS).

    Science.gov (United States)

    Pan, Yue; Zhang, Qiangling; Zhou, Wenzhao; Zou, Xue; Wang, Hongmei; Huang, Chaoqun; Shen, Chengyin; Chu, Yannan

    2017-05-01

    Proton transfer reaction mass spectrometry (PTR-MS) has played an important role in the field of real-time monitoring of trace volatile organic compounds (VOCs) due to its advantages such as low limit of detection (LOD) and fast time response. Recently, a new technology of proton extraction reaction mass spectrometry (PER-MS) with negative ions OH(-) as the reagent ions has also been presented, which can be applied to the detection of VOCs and even inorganic compounds. In this work, we combined the functions of PTR-MS and PER-MS in one instrument, thereby developing a novel technology called dipolar proton transfer reaction mass spectrometry (DP-PTR-MS). The selection of PTR-MS mode and PER-MS mode was achieved in DP-PTR-MS using only water vapor in the ion source and switching the polarity. In this experiment, ketones (denoted by M) were selected as analytes. The ketone (molecular weight denoted by m) was ionized as protonated ketone [M + H](+) [mass-to-charge ratio (m/z) m + 1] in PTR-MS mode and deprotonated ketone [M - H](-) (m/z m - 1) in PER-MS mode. By comparing the m/z value of the product ions in the two modes, the molecular weight of the ketone can be positively identified as m. Results showed that whether it is a single ketone sample or a mixed sample of eight kinds of ketones, the molecular weights can be detected with DP-PTR-MS. The newly developed DP-PTR-MS not only maintains the original advantages of PTR-MS and PER-MS in sensitive and rapid detection of ketones, but also can estimate molecular weight of ketones. Graphical Abstract ᅟ.

  2. Characterizing the binding motifs of 11 common human HLA‐DP and HLA‐DQ molecules using NNAlign

    DEFF Research Database (Denmark)

    Andreatta, Massimo; Nielsen, Morten

    2012-01-01

    in the pattern of amino acid preferences at core positions, with conserved hydrophobic/aromatic anchors at P1 and P6, and an additional hydrophobic anchor at P9 in some variants. These results confirm the existence of a previously hypothesized supertype encompassing the most common DP alleles. Conversely......, the binding motifs for DQ molecules appear more divergent, displaying unconventional anchor positions and in some cases rather unspecific amino acid preferences....

  3. Measurement of the vector and tensor analyzing powers for dp- elastic scattering at 880 MeV

    CERN Document Server

    Kurilkin, P K; Uesaka, T; Suda, K; Gurchin, Yu V; Isupov, A Yu; Itoh, K; Janek, M; Karachuk, J -T; Kawabata, T; Khrenov, A N; Kiselev, A S; Kizka, V A; Krasnov, V A; Ladygina, N B; Livanov, A N; Maeda, Y; Malakhov, A I; Piyadin, S M; Reznikov, S G; Sakaguchi, S; Sakai, H; Sasamoto, Y; Sekiguchi, K; Shikhalev, M A; Vasiliev, T A; Witala, H

    2012-01-01

    The vector Ay and tensor analyzing powers Ayy and Axx for dp- elastic scattering were measured at Td = 880 MeV over the c.m. angular range from 60 to 140 degrees at the JINR Nuclotron. The data are compared with predictions of different theoretical models based on the use of nucleon-nucleon forces only. The observed discrepancies of the measured analyzing powers from the calculations require the consideration of additional mechanisms.

  4. Plant defense against insect herbivores

    DEFF Research Database (Denmark)

    Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

    2013-01-01

    defense responses. Plants also apply morphological features like waxes, trichomes and latices to make the feeding more difficult for the insects. Extrafloral nectar, food bodies and nesting or refuge sites are produced to accommodate and feed the predators of the herbivores. Meanwhile, herbivorous insects......Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar....... Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight...

  5. Lexical Link Analysis (LLA) Application: Improving Web Service to Defense Acquisition Visibility Environment (DAVE)

    Science.gov (United States)

    2015-05-01

    1 LEXICAL LINK ANALYSIS (LLA) APPLICATION: IMPROVING WEB SERVICE TO DEFENSE ACQUISITION VISIBILITY ENVIRONMENT(DAVE) May 13-14, 2015 Dr. Ying...Improving Web Service to Defense Acquisition Visibility Environment (DAVE) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR...to install the LLA/CLA/SSA system as a web service in the Defense Acquisition Visibility Environment (DAVE) test bed via the AT&L eBusiness Center

  6. Interwar U.S. and Japanese National Product and Defense Expenditure

    Science.gov (United States)

    2003-06-01

    Selected investment price indexes for Japan . ................... 19 Figure 7. Japanese defense expenditure in constant yen terms. Amounts are...CIM D0007249.A /Final June 2003 Interwar U.S. and Japanese National Product and Defense Expenditure William D. O’Neil 4825 Mark Center...and Japanese National Product and Defense Expenditure 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT

  7. Defense Modernization Plans Through the 2020s: Addressing the Bow Wave

    Science.gov (United States)

    2016-04-30

    Johns Hopkins University’s School of Advanced International Studies. He is a term member of the Council on Foreign Relations and was named one of...45 p.m. Chair: Andrew Hunter, Senior Fellow in the International Security Program, Director of Defense-Industrial Initiatives Group, Center for...Strategic International Studies Defense Modernization Plans Through the 2020s: Addressing the Bow Wave Todd Harrison, Director, Defense Budget Analysis

  8. The neutron-proton charge-exchange amplitudes measured in the dp {yields} ppn reaction

    Energy Technology Data Exchange (ETDEWEB)

    Mchedlishvili, D.; Chiladze, D. [Tbilisi State University, High Energy Physics Institute, Tbilisi (Georgia); Forschungszentrum Juelich, Institut fuer Kernphysik and Juelich Centre for Hadron Physics, Juelich (Germany); Barsov, S.; Dzyuba, A. [Petersburg Nuclear Physics Institute, High Energy Physics Department, Gatchina (Russian Federation); Carbonell, J. [Universite Paris-Sud, IN2P3-CNRS, Institut de Physique Nucleaire, Orsay Cedex (France); Dymov, S. [JINR, Laboratory of Nuclear Problems, Dubna (Russian Federation); Universitaet Erlangen-Nuernberg, Physikalisches Institut II, Erlangen (Germany); Engels, R.; Gebel, R.; Hartmann, M.; Kacharava, A.; Kamerdzhiev, V.; Lehrach, A.; Lorentz, B.; Maier, R.; Ohm, H.; Prasuhn, D.; Rathmann, F.; Serdyuk, V.; Seyfarth, H.; Stein, H.J.; Stockhorst, H.; Stroeher, H. [Forschungszentrum Juelich, Institut fuer Kernphysik and Juelich Centre for Hadron Physics, Juelich (Germany); Glagolev, V. [JINR, Laboratory of High Energies, Dubna (Russian Federation); Grigoryev, K.; Mikirtychyants, M.; Mikirtychyants, S.; Valdau, Yu. [Forschungszentrum Juelich, Institut fuer Kernphysik and Juelich Centre for Hadron Physics, Juelich (Germany); Petersburg Nuclear Physics Institute, High Energy Physics Department, Gatchina (Russian Federation); Goslawski, P.; Khoukaz, A.; Mielke, M.; Papenbrock, M. [Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Keshelashvili, I. [Tbilisi State University, High Energy Physics Institute, Tbilisi (Georgia); University of Basel, Department of Physics, Basel (Switzerland); Komarov, V.; Kulikov, A. [JINR, Laboratory of Nuclear Problems, Dubna (Russian Federation); Kulessa, P. [H. Niewodniczanski Institute of Nuclear Physics PAN, Krakow (Poland); Lomidze, N.; Nioradze, M.; Tabidze, M. [Tbilisi State University, High Energy Physics Institute, Tbilisi (Georgia); Macharashvili, G. [Tbilisi State University, High Energy Physics Institute, Tbilisi (Georgia); JINR, Laboratory of Nuclear Problems, Dubna (Russian Federation); Merzliakov, S. [Forschungszentrum Juelich, Institut fuer Kernphysik and Juelich Centre for Hadron Physics, Juelich (Germany); JINR, Laboratory of Nuclear Problems, Dubna (Russian Federation); Steffens, E. [Universitaet Erlangen-Nuernberg, Physikalisches Institut II, Erlangen (Germany); Trusov, S. [Forschungszentrum Rossendorf, Institut fuer Kern- und Hadronenphysik, Dresden (Germany); Uzikov, Yu. [JINR, Laboratory of Nuclear Problems, Dubna (Russian Federation); M. V. Lomonosov Moscow State University, Department of Physics, Moscow (Russian Federation); Wilkin, C. [UCL, Physics and Astronomy Department, London (United Kingdom)

    2013-04-15

    The unpolarised differential cross section and the two deuteron tensor analysing powers A{sub xx} and A{sub yy} of the vector dp {yields} {l_brace}pp{r_brace}{sub s}n charge-exchange reaction have been measured with the ANKE spectrometer at the COSY storage ring. Using deuteron beams with energies 1.2, 1.6, 1.8, and 2.27GeV, data were obtained for small momentum transfers to a {l_brace}pp{r_brace}{sub s} system with low excitation energy. The results at the three lower energies are consistent with impulse approximation predictions based upon the current knowledge of the neutron-proton amplitudes. However, at 2.27GeV, where these amplitudes are far more uncertain, agreement requires a reduction in the overall double-spin-flip contribution, with an especially significant effect in the longitudinal direction. These conclusions are supported by measurements of the deuteron-proton spin-correlation parameters C{sub x,x} and C{sub y,y} that were carried out in the vector dvector p {yields} {l_brace}pp{r_brace}{sub s}n reaction at 1.2 and 2.27GeV. The values obtained for the proton analysing power A{sub y}{sup p} also suggest the need for a radical re-evaluation of the neutron-proton elastic scattering amplitudes at the higher energy. It is therefore clear that such measurements can provide a valuable addition to the neutron-proton database in the charge-exchange region. (orig.)

  9. Microstructure and Fatigue Properties of Laser Welded DP590 Dual-Phase Steel Joints

    Science.gov (United States)

    Xie, Chaojie; Yang, Shanglei; Liu, Haobo; Zhang, Qi; Cao, Yaming; Wang, Yuan

    2017-08-01

    In this paper, cold-rolled DP590 dual-phase steel sheets with 1.5 mm thickness were butt-welded by a fiber laser, and the evolution and effect on microhardness, tensile property and fatigue property of the welded joint microstructure were studied. The results showed that the base metal is composed of ferrite and martensite, with the martensite dispersed in the ferrite matrix in an island manner. The microstructure of the weld zone was lath-shaped martensite that can be refined further by increasing the welding speed, while the heat-affected zone was composed of ferrite and tempered martensite. The microhardness increased with increasing welding speed, and the hardness reached its highest value—393.8 HV—when the welding speed was 5 m/min. Static tensile fracture of the welded joints always occurred in the base metal, and the elongation at break was more than 16%. The conditional fatigue limits of the base metal and the weld joints were 354.2 and 233.6 MPa, respectively, under tension-tension fatigue tests with a stress rate of 0.1. After observation of the fatigue fracture morphology, it was evident that the fatigue crack of the base metal had sprouted into the surface pits and that its expansion would be accelerated under the action of a secondary crack. The fatigue source of the welded joint was generated in the weld zone and expanded along the martensite, forming a large number of fatigue striations. Transient breaking, which occurred in the heat-affected zone of the joint as a result of the formation of a large number of dimples, reflected the obvious characteristics of ductile fracture.

  10. A Deep Neural Network Model for Rainfall Estimation UsingPolarimetric WSR-88DP Radar Observations

    Science.gov (United States)

    Tan, H.; Chandra, C. V.; Chen, H.

    2016-12-01

    Rainfall estimation based on radar measurements has been an important topic for a few decades. Generally, radar rainfall estimation is conducted through parametric algorisms such as reflectivity-rainfall relation (i.e., Z-R relation). On the other hand, neural networks are developed for ground rainfall estimation based on radar measurements. This nonparametric method, which takes into account of both radar observations and rainfall measurements from ground rain gauges, has been demonstrated successfully for rainfall rate estimation. However, the neural network-based rainfall estimation is limited in practice due to the model complexity and structure, data quality, as well as different rainfall microphysics. Recently, the deep learning approach has been introduced in pattern recognition and machine learning areas. Compared to traditional neural networks, the deep learning based methodologies have larger number of hidden layers and more complex structure for data representation. Through a hierarchical learning process, the high level structured information and knowledge can be extracted automatically from low level features of the data. In this paper, we introduce a novel deep neural network model for rainfall estimation based on ground polarimetric radar measurements .The model is designed to capture the complex abstractions of radar measurements at different levels using multiple layers feature identification and extraction. The abstractions at different levels can be used independently or fused with other data resource such as satellite-based rainfall products and/or topographic data to represent the rain characteristics at certain location. In particular, the WSR-88DP radar and rain gauge data collected in Dallas - Fort Worth Metroplex and Florida are used extensively to train the model, and for demonstration purposes. Quantitative evaluation of the deep neural network based rainfall products will also be presented, which is based on an independent rain gauge

  11. Design and accomplishment of the dissertation and graduation defense in seven-year clinical medicine program (pharmacy direction)%七年制临床医学专业(药学方向)学生毕业论文的设计与答辩

    Institute of Scientific and Technical Information of China (English)

    郝国祥; 张庆柱; 邵伟; 张泰松

    2012-01-01

    为了提高七年制临床医学专业(药学方向)学生的培养质量,提高学生的科研与论文写作能力,山东大学药学院对该专业学生的专题实习、毕业论文写作与答辩进行了探索,本文就专题实习的方式与内容、导师组成与选题、毕业论文的撰写与要求,以及论文答辩的组织与实施等方面的问题进行了探讨.%In order to improve the quality of seven-year clinical medicine program (pharmacy direction) students,increase their abilities of research and thesis writing,graduation thesis defense were organized after special practice.This article detailed the special practice and the graduation thesis defense,including the methods and contents of special practice,composition of tutors,selection of dissertation topic,requirements of dissertation writing,organization and implementation of graduation defense.

  12. The Relationship Between DP, Fracture Degree and Mechanical Strength of Cellulose Iβ in Insulation Paper by Molecular Dynamic Simulations

    Science.gov (United States)

    Wang, You-Yuan; Yang, Tao; Tian, Miao; Liao, Rui-Jin

    2013-09-01

    The degree of polymerization (DP) has been regarded as an important symbol of mechanical strength, reflecting the aging condition of transformer insulation paper. In this article, a new concept called fracture degree is proposed on the basis of DP. First, nine cellulose Iβ crystal models with different fracture degrees were built. Then relevant mechanical parameters and hydrogen bond numbers were calculated by molecular dynamics (MD) simulation. Results showed that during the aging process of insulation paper with fracture of cellulose chain, the elastic constant C33 produces appreciable impact on the Young's modulus (E). With the decrease of DP and increase of fracture degree, the Young's modulus step decreases. To the 50% and 100% fracture degree models respectively, the relationship between their different degrees of polymerization and Young's modulus is subjected to similar exponential distributions. With the increase of the fracture degree, the average hydrogen bond number drops, and the change rules apply to the Young's modulus. Since hydrogen bond is the main factor of mechanical strength, it can be inferred that the fracture degree influences mechanical strength seriously.

  13. Effect of strain rate on shear properties and fracture characteristics of DP600 and AA5182-O sheet metal alloys

    Directory of Open Access Journals (Sweden)

    Rahmaan Taamjeed

    2015-01-01

    Full Text Available Shear tests were performed at strain rates ranging from quasi-static (.01 s−1 to 600 s−1 for DP600 steel and AA5182-O sheet metal alloys at room temperature. A miniature sized shear specimen was modified and validated in this work to perform high strain rate shear testing. Digital image correlation (DIC techniques were employed to measure the strains in the experiments, and a criterion to detect the onset of fracture based on the hardening rate of the materials is proposed. At equivalent strains greater than 20%, the DP600 and AA5182 alloys demonstrated a reduced work hardening rate at elevated strain rates. At lower strains, the DP600 shows positive rate sensitivity while the AA5182 was not sensitive to strain rate. For both alloys, the equivalent fracture strain and elongation to failure decreased with strain rate. A conversion of the shear stress to an equivalent stress using the von Mises yield criterion provided excellent agreement with the results from tensile tests at elevated strain rates. Unlike the tensile test, the shear test is not limited by the onset of necking so the equivalent stress can be determined over a larger range of strain.

  14. Localization of serotonin receptors in the rat thalamus by electrophysiology and the action of 5-HTP-DP-hex.

    Science.gov (United States)

    Emmers, R; Tamir, H; Wilchek, M

    1989-06-01

    This study was designed to pinpoint the site at which N-hexanoyl-5-hydroxytryptophyl-5-hydroxytryptophan amide (5-HTP-DP-hex) exerts its previously reported effect on thalamic neurons in rats. The animals were prepared under chloralose-urethane anesthesia for a stereotaxic approach to either the nucleus ventralis posterolateralis (nVPL) or the centrum medianum-parafascicularis complex (CM-Pf) of the thalamus. Individual neurons in these nuclei were separately activated by single-pulse stimulation of the sciatic nerve or the thalamic fibers that form reciprocal connections between the CM-Pf and the second somatosensory (SII) region of the nVPL. Poststimulus time histograms were constructed from computer readouts of the stimulus-evoked responses of a neuron during a 500-ms period accumulated in a digital computer 100X. In addition, the number of spikes accumulated in each histogram was compared to the number of spikes accumulated under identical conditions on the same neuron after intracarotid infusion of 5-HTP-DP-hex. The effect of the drug was reversed by the infusion of 5-HTP. Statistical evaluation of the accumulated spike counts indicated that 5-HTP-DP-hex suppressed only the excitation of CM-Pf neurons from the SII of the nVPL; the input of the sciatic nerve into the CM-Pf remained unaltered. Furthermore, no effect was exerted by this dipeptide on the afferent excitation of neurons in the SII of the nVPL.(ABSTRACT TRUNCATED AT 250 WORDS)

  15. Structure of the ThDP-dependent enzyme benzaldehyde lyase refined to 1.65 Å resolution

    Energy Technology Data Exchange (ETDEWEB)

    Maraite, Andy; Schmidt, Thomas; Ansörge-Schumacher, Marion B. [Department of Biotechnology, Faculty of Natural Sciences, RWTH Aachen University, Worringerweg 1, 52074 Aachen (Germany); Brzozowski, A. Marek; Grogan, Gideon, E-mail: grogan@ysbl.york.ac.uk [Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW (United Kingdom); Department of Biotechnology, Faculty of Natural Sciences, RWTH Aachen University, Worringerweg 1, 52074 Aachen (Germany)

    2007-07-01

    The X-ray crystal structure of the ThDP-dependent enzyme benzaldehyde lyase has been refined to 1.65 Å. Benzaldehyde lyase (BAL; EC 4.1.2.38) is a thiamine diphosphate (ThDP) dependent enzyme that catalyses the enantioselective carboligation of two molecules of benzaldehyde to form (R)-benzoin. BAL has hence aroused interest for its potential in the industrial synthesis of optically active benzoins and derivatives. The structure of BAL was previously solved to a resolution of 2.6 Å using MAD experiments on a selenomethionine derivative [Mosbacher et al. (2005 ▶), FEBS J.272, 6067–6076]. In this communication of parallel studies, BAL was crystallized in an alternative space group (P2{sub 1}2{sub 1}2{sub 1}) and its structure refined to a resolution of 1.65 Å, allowing detailed observation of the water structure, active-site interactions with ThDP and also the electron density for the co-solvent 2-methyl-2,4-pentanediol (MPD) at hydrophobic patches of the enzyme surface.

  16. Individual or synchronous biodegradation of di-n-butyl phthalate and phenol by Rhodococcus ruber strain DP-2

    Energy Technology Data Exchange (ETDEWEB)

    He, Zhixing; Niu, Chengzhen; Lu, Zhenmei, E-mail: lzhenmei@zju.edu.cn

    2014-05-01

    Highlights: • A Rhodococcus ruber strain degraded DBP and phenol. • Degradation kinetics of DBP or phenol fit modified first-order models. • Degradation interaction between DBP and phenol was studied by strain DP-2. • The degradation genes transcriptional were quantified by RT-qPCR. - Abstract: The bacterial strain DP-2, identified as Rhodococcus ruber, is able to effectively degrade di-n-butyl phthalate (DBP) and phenol. Degradation kinetics of DBP and phenol at different initial concentrations revealed DBP and phenol degradation to fit modified first-order models. The half-life of DBP degradation ranged from 15.81 to 27.75 h and phenol degradation from 14.52 to 45.52 h under the initial concentrations of 600–1200 mg/L. When strain DP-2 was cultured with a mixture of DBP (800 mg/L) and phenol (700 mg/L), DBP degradation rate was found to be only slightly influenced; however, phthalic acid (PA) accumulated, and phenol degradation was clearly inhibited during synchronous degradation. Transcriptional levels of degradation genes, phenol hydroxylase (pheu) and phthalate 3,4-dioxygenase (pht), decreased significantly more during synchronous degradation than during individual degradation. Quantitative estimation of individual or synchronous degradation kinetics is essential to manage mixed hazardous compounds through biodegradation in industrial waste disposal.

  17. Development and psychometric properties of a belief-based Physical Activity Questionnaire for Diabetic Patients (PAQ-DP

    Directory of Open Access Journals (Sweden)

    Ghofranipour Fazlollah

    2010-11-01

    Full Text Available Abstract Background This study carried out to develop a scale for assessing diabetic patients' perceptions about physical activity and to test its psychometric properties (The Physical Activity Questionnaire for Diabetic Patients-PAQ-DP. Methods An item pool extracted from the Theory of Planned Behavior literature was generated. Then an expert panel evaluated the items by assessing content validity index and content validity ratio. Consequently exploratory factor analysis (EFA was performed to indicate the scale constructs. In addition reliability analyses including internal consistency and test-retest analysis were carried out. Results In all a sample of 127 women with diabetes participated in the study. Twenty-two items were initially extracted from the literature. A six-factor solution (containing 19 items emerged as a result of an exploratory factor analysis namely: instrumental attitude, subjective norm, perceived behavioral control, affective attitude, self-identity, and intention explaining 60.30% of the variance observed. Additional analyses indicated satisfactory results for internal consistency (Cronbach's alpha ranging from 0.54 to 0.8 and intraclass correlation coefficients (ranging from 0.40 to 0.92. Conclusions The Physical Activity Questionnaire for Diabetic Patients (PAQ-DP is the first instrument that applies the Theory of Planned Behavior in its constructs. The findings indicated that the PAQ-DP is a reliable and valid measure for assessing physical activity perceptions and now is available and can be used in future studies.

  18. Polybrominated diphenyl ethers (PBDEs) and dechlorane plus (DP) in a conventional wastewater treatment plant (WWTP) in Shanghai: seasonal variations and potential sources.

    Science.gov (United States)

    Xiang, Nan; Chen, Ling; Meng, Xiang-Zhou; Li, Yu-Lin; Liu, Zhigang; Wu, Bing; Dai, Lingling; Dai, Xiaohu

    2014-07-15

    Wastewater treatment plants (WWTPs) are considered an important medium for the transport and transformation of organic pollutants, such as polybrominated diphenyl ethers (PBDEs) and dechlorane plus (DP). However, limited data on PBDEs and no data on DP were available regarding wastewater and sludge from China, especially in Shanghai, one of the most developed cities in China. This study examined the occurrence of PBDEs and DP in a conventional WWTP in Shanghai for one year. The levels of the total PBDEs in the influent and dewatered sludge ranged from 5.31 to 27.9 ng/L and 31.0 to 99.5 ng/g, respectively, which were at the low end of the global range. DP was reported in wastewater with a mean concentration of 0.46 ng/L (range: 0.05 to 1.40 ng/L) and sludge contained DP in the range of 1.1 to 2.0 ng/g. For both PBDEs and DP, there were no significant seasonal variations observed in the four seasons. Indoor dust and outdoor air could be two main sources of PBDEs and DP in the WWTP. In both the influent and sewage sludge, BDE-209 was the most abundant congener, with contributions to the total PBDE levels ranging from 52.9 to 82.6% and 82.7 to 84.0%, respectively. The fraction of anti-DP was consistently higher than that of syn-DP, and the average of fsyn ranged from 0.16 to 0.33, which fell in the range of two commercial DP mixtures. The annual releases of PBDEs and DP via sewage sludge from WWTPs in Shanghai were estimated to be 6,370 g and 164.8 g, respectively. The fate and risk of these compounds after being released into the environment require further research. To the best of our knowledge, this study is the first to report on the occurrence of DP in wastewater.

  19. PROFIBUS-DP现场总线技术在HFW焊管机组电气系统中的应用%Application of PROFIBUS-DP Field Bus Technology in HFW Pipe Units Electrical System

    Institute of Scientific and Technical Information of China (English)

    刘换军; 王华; 王小毅

    2011-01-01

    简要介绍了工业现场总线PROFIBUS-DP系统的特点及其应用.重点介绍了某HFW机组以S7-400 CPU作为核心控制器件,使用PROFIBUS-DP现场总线技术实现了MM440变频器、主操作台0S3和S7-400西门子PLC之间的通讯技术,对系统构成、总线连接及程序设计分别进行了论述.该PROFIBUS-DP现场总线系统具有结构简单、信息量大、可靠性高、维护费用低等优点,且运行效果良好.%In this article,it briefly introduced the characteristics and application of industry field bus PROFIBUS-DP system,emphatically introduced that some units taking S7 - 400 CPU as the most important control device,using PROFIBUS-DP field bus technology realized communication between MM440 frequency converter,master operating station and S7-400 Siemens PLC.and the system components,bus connection and program design were separately expatiated. The PROFIBUS-DP field bus system possesses several advantages,such as simple structure,much information,high realiability.low maintenance cost and etc.,and its application effect is good,so it is worthy of to be promoted in welded pipe production line.

  20. Antiviral Defenses in Plants through Genome Editing

    Science.gov (United States)

    Romay, Gustavo; Bragard, Claude

    2017-01-01

    Plant–virus interactions based-studies have contributed to increase our understanding on plant resistance mechanisms, providing new tools for crop improvement. In the last two decades, RNA interference, a post-transcriptional gene silencing approach, has been used to induce antiviral defenses in plants with the help of genetic engineering technologies. More recently, the new genome editing systems (GES) are revolutionizing the scope of tools available to confer virus resistance in plants. The most explored GES are zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats/Cas9 endonuclease. GES are engineered to target and introduce mutations, which can be deleterious, via double-strand breaks at specific DNA sequences by the error-prone non-homologous recombination end-joining pathway. Although GES have been engineered to target DNA, recent discoveries of GES targeting ssRNA molecules, including virus genomes, pave the way for further studies programming plant defense against RNA viruses. Most of plant virus species have an RNA genome and at least 784 species have positive ssRNA. Here, we provide a summary of the latest progress in plant antiviral defenses mediated by GES. In addition, we also discuss briefly the GES perspectives in light of the rebooted debate on genetic modified organisms (GMOs) and the current regulatory frame for agricultural products involving the use of such engineering technologies. PMID:28167937

  1. Design of DP/PA Link based on STM32%基于STM32的DP/PA Link设计

    Institute of Scientific and Technical Information of China (English)

    张彪; 范福基

    2014-01-01

    An implement method for providing the network conversion to the equipments between host redundancy PROFIBUS-PA systems and lower non-redundant PROFIBUS-PA systems is introduced, which uses the matching work of MCU, ARM and FPGA chips. The method would be a safe and reliable conversion program.%给出了通过使用MCU、ARM和FPGA芯片的配合工作,为上位冗余PROFIBUS-DP主站系统与下位非冗余PROFIBUS-PA设备系统之间提供网络转换的实现方法,该方法安全可靠。

  2. 75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot...

    Science.gov (United States)

    2010-04-21

    ... Regulation Supplement; DoD Pilot Mentor-Protege Program AGENCY: Defense Acquisition Regulations System... Acquisition Regulation Supplement (DFARS) Appendix I, DoD Pilot Mentor-Protege Program; OMB Control Number... Mentor-Protege Program have been met. The purposes of the Program are to (1) provide incentives to...

  3. Defense Strategies Against Modern Botnets

    CERN Document Server

    Stankovic, Srdjan

    2009-01-01

    Botnets are networks of compromised computers with malicious code which are remotely controlled and which are used for starting distributed denial of service (DDoS) attacks, sending enormous number of e-mails (SPAM) and other sorts of attacks. Defense against modern Botnets is a real challenge. This paper offers several strategies for defense against Botnets with a list and description of measures and activities which should be carried out in order to establish successful defense. The paper also offers parallel preview of the strategies with their advantages and disadvantages considered in accordance with various criteria.

  4. Autonomous Defensive Space Control via On-Board Artificial Neural Networks

    Science.gov (United States)

    2007-04-01

    AUTONOMOUS DEFENSIVE SPACE CONTROL VIA ON-BOARD ARTIFICIAL NEURAL NETWORKS Michael T. Manor, Major, USAF April 2007...TITLE AND SUBTITLE Sutonomous Defensive Space Control via On-Board Artificial Neural Networks 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...11 HOW ARTIFICIAL NEURAL NETWORKS WORK

  5. 75 FR 64710 - Availability of the Fiscal Year 2009 Department of Defense Services Contracts Inventory

    Science.gov (United States)

    2010-10-20

    ... of the Secretary Availability of the Fiscal Year 2009 Department of Defense Services Contracts... Fiscal Year 2008 (NDAA 08) section 807, the Office of the Director, Defense Procurement and Acquisition Policy, Office of Program Acquisition and Strategic Sourcing (DPAP/PASS) will make available to the...

  6. Defense Weather Satellites: DOD Faces Acquisition Challenges for Addressing Capability Needs

    Science.gov (United States)

    2016-07-07

    design . Our work on the NPOESS program has shown that without clear lines of authority, conflicts between satellite users hampered decisions, such as for...DEFENSE WEATHER SATELLITES DOD Faces Acquisition Challenges for Addressing Capability Needs Statement of Cristina T...Environment, Committee on Science, Space, and Technology, House of Representatives July 2016 DEFENSE WEATHER SATELLITES DOD Faces Acquisition

  7. 76 FR 38050 - Defense Federal Acquisition Regulation Supplement; Management of Manufacturing Risk in Major...

    Science.gov (United States)

    2011-06-29

    ... Regulation Supplement; Management of Manufacturing Risk in Major Defense Acquisition Programs (DFARS Case... require the approval of the Office of Management and Budget under the Paperwork Reduction Act (44 U.S.C... Government procurement. Mary Overstreet, Editor, Defense Acquisition Regulations System. Therefore, 48...

  8. 78 FR 65244 - Defense Federal Acquisition Regulation Supplement: Contractor Personnel Supporting U.S. Armed...

    Science.gov (United States)

    2013-10-31

    ... it with the changes in applicability, terminology, and other revisions made by Department of Defense..., including OCS program management, contract support integration, and integration of defense contractor..., terminology aid in determining which groups qualify for different types of Government support and are based...

  9. Quadrennial Defense Review and Ballistic Missile Defense Review

    Science.gov (United States)

    2010-03-11

    global defense posture 3 BMDR Highlights • Outlines a strategy and policy framework to – Defend the homeland against limited ballistic missile attack...abroad – Collaborate closely with allies and partners – Pursue a cooperative and tailored global defense posture – Strengthen US civilian capacity...reviews in 2010 – QDR and BMDR released February 1, 2010 – Nuclear Posture Review to be released this spring – Space Posture Review, with Director of

  10. Molecular strategies of plant defense and insect counter-defense

    Institute of Scientific and Technical Information of China (English)

    KEYANZHU-SALZMAN; JIAN-LONGBI; TONG-XIANLIU

    2005-01-01

    The prediction of human population growth worldwide indicates there will be a need to substantially increase food production in order to meet the demand on food supply.This can be achieved in part by the effective management of insect pests. Since plants have co-evolved with herbivorous insects for millions of years, they have developed an array of defense genes to protect themselves against a wide variety of chewing and sucking insects.Using these naturally-occurring genes via genetic engineering represents an environmentally friendly insect pest-control measure. Insects, however, have been actively evolving adaptive mechanisms to evade natural plant defenses. Such evolved adaptability undoubtedly has helped insects during the last century to rapidly overcome a great many humanimposed management practices and agents, including chemical insecticides and genetically engineered plants. Thus, better understanding of the molecular and genetic basis of plant defense and insect counter-defense mechanisms is imperative, not only from a basic science perspective, but also for biotechnology-based pest control practice. In this review, we emphasize the recent advance and understanding of molecular strategies of attack-counterattack and defense-counter-defense between plants and their herbivores.

  11. Investigation of Flow Instabilities in the Inlet Ducts of DP-1C VTOL Aircraft

    Science.gov (United States)

    Lepicovsky, Jan

    2008-01-01

    An investigation of flow instabilities in the inlet ducts of a two-engine vertical takeoff and landing aircraft DP-1C is described in this report. Recent tests revealed that the engines stall during run ups while the aircraft is operating on the ground. These pop stalls occurred at relatively low power levels, sometimes as low as 60 percent of the engine full speed. Inability to run the engines up to the full speed level is attributed to in-ground effects associated with hot gas ingestion. Such pop stalls were never experienced when the aircraft was tested on a elevated grid platform, which ensured that the aircraft was operating in out-of-the-ground-effect conditions. Based on available information on problems experienced with other vertical takeoff and landing aircraft designs, it was assumed that the engine stalls were caused by partial ingestion of hot gases streaming forward from the main exit nozzle under the aircraft inlets, which are very close to the ground. It was also suggested that the nose wheel undercarriage, located between the inlets, may generate vortices or an unstable wake causing intense mixing of hot exit gases with incoming inlet flow, which would enhance the hot gas ingestion. After running a short three-day series of tests with fully instrumented engine inlets, it is now believed the most probable reason for engine pop stalls are random ingestions of a vortex generated between the two streams moving in opposite directions: outbound hot gas stream from the main nozzle close to the ground and inbound inlet flow above. Originally, the vortex is in a horizontal plane. However, at a certain velocity ratio of these two streams, the vortex attaches either to the ground or the aircraft surface at one end and the other end is swallowed by one of the aircraft inlets. Once the vortex enters the inlet duct, a puff of hot air can be sucked through the vortex core into the engine, which causes a serious inlet flow field distortion followed by an engine

  12. Chronic beryllium disease, HLA-DPB1, and the DP peptide binding groove.

    Science.gov (United States)

    Silveira, Lori J; McCanlies, Erin C; Fingerlin, Tasha E; Van Dyke, Michael V; Mroz, Margaret M; Strand, Matthew; Fontenot, Andrew P; Bowerman, Natalie; Dabelea, Dana M; Schuler, Christine R; Weston, Ainsley; Maier, Lisa A

    2012-10-15

    Multiple epidemiologic studies demonstrate associations between chronic beryllium disease (CBD), beryllium sensitization (BeS), and HLA-DPB1 alleles with a glutamic acid residue at position 69 (E69). Results suggest that the less-frequent E69 variants (non-*0201/*0202 alleles) might be associated with greater risk of CBD. In this study, we sought to define specific E69-carrying alleles and their amino acid sequences in the DP peptide binding groove, as well as their relationship to CBD and BeS risk, using the largest case control study to date. We enrolled 502 BeS/CBD subjects and 653 beryllium-exposed controls from three beryllium industries who gave informed consent for participation. Non-Hispanic white cases and controls were frequency-matched by industry. HLA-DPB1 genotypes were determined using sequence-specific primer PCR. The E69 alleles were tested for association with disease individually and grouped by amino acid structure using logistic regression. The results show that CBD cases were more likely than controls to carry a non-*02 E69 allele than an *02 E69, with odds ratios (95% confidence interval) ranging from 3.1 (2.1-4.5) to 3.9 (2.6-5.9) (p < 0.0001). Polymorphic amino acids at positions 84 and 11 were associated with CBD: DD versus GG, 2.8 (1.8-4.6), p < 0.0001; GD versus GG, 2.1 (1.5-2.8), p < 0.0001; LL versus GG, 3.2 (1.8-5.6), p < 0.0001; GL versus GG, 2.8 (2.1-3.8), p < 0.0001. Similar results were found within the BeS group and CBD/BeS combined group. We conclude that the less frequent E69 alleles confer more risk for CBD than does *0201. Recent studies examining how the composition and structure of the binding pockets influence peptide binding in MHC genes, as well of studies showing the topology of the TCR to likely bind DPB1 preferentially, give plausible biological rationale for these findings.

  13. FEBEX-DP. Dismantling the ''full-scale engineered barrier experiment'' after 18 years of operation at the Grimsel Test Site, Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Kober, Florian; Gaus, Irina [Nagra, Wettingen (Switzerland)

    2015-07-01

    dismantling project (FEBEX-DP) are: - Characterization of the key physical properties (e.g., density, water content) of the barrier and their distribution, - Characterization of corrosion and microbiological processes on instruments and coupons resulting from evolving redox conditions and saturation states, including gas analysis, - Characterization macro- and micro level studies of mineralogical interactions at material interfaces (e.g., cement-bentonite or iron-bentonite, rock-bentonite), - Assessment of sensor performance, - Further increasing understanding of the thermo-hydro-mechanical (THM) and thermo-hydro-chemical (THC) processes through integration of monitoring and dismantling results. An intensive laboratory program will be conducted in 2015/2016 in order to achieve the outlined main objectives. It includes extensive mineralogical, chemical and biological investigations of the buffer and the related interfaces. It will be accompanied by pre- and post dismantling modeling efforts. Unique data are expected after completing one of the longest running 1:1 in-situ EBS experiment under continued heating and natural saturation conditions. It will further consolidate the EBS knowledge and will act as a benchmark for major coupled modeling codes. The dismantling project is set-up as an international project with partners from Europe, Asia and North America. Further information can are under http://www.grimsel.com/gts-phase-vi/febex-dp/febex-dp-introduction.

  14. Defense AT&L. March-April 2010

    Science.gov (United States)

    2010-04-01

    with Redstone Arsenal, Ala ., to discuss common avionics issues. 59 Defense AT&L: March-April 2010 program test issues will inform both the test...Wright-Patterson Air Force Base, Ohio, could easily collaborate with Redstone Arsenal, Ala ., to discuss common avionics issues if both were members of

  15. A Strategic Defense Initiative Organization Software Testing Initiative

    Science.gov (United States)

    1990-10-01

    Pentagon Washir gton, DC 20301-7100 Other Defense Technical Information Center 2 Cameron Station Alexandria, VA 22314 Dr. Dan Alpert , Director Program in...Science, Technology & Society University of Illinois Room 201 912-1/2 West Illinois Street Urbana, Illinois 61801 IDA General Larry D. Welch, HQ 1 Mr

  16. Ingestion of milk containing the Dp2 peptide, a dust mite allergen, protects mice from allergic airway inflammation and hyper-responsiveness

    Science.gov (United States)

    2013-01-01

    Background Allergen-specific immunotherapy has been demonstrated to have potential for the treatment of allergic diseases. Transgenic animals are currently the best available bioreactors to produce recombinant proteins, which can be secreted in milk. It has not been clearly demonstrated whether milk from transgenic animals expressing recombinant allergens has immunomodulatory effects on allergic asthma. Methods We aimed to determine whether the oral administration of milk containing a mite allergen can down-regulate allergen-specific airway inflammation. Transgenic CD-1 mice that express a recombinant group 2 allergen from Dermatophagoides pteronyssinus (Dp2) in their milk were generated using an embryonic gene-microinjection technique. Mouse pups were fed transgenic Dp2-containing milk or wild-type milk. Subsequently, these mice were sensitized and challenged with Dp2 to induce allergic airway inflammation. Results Upon sensitization and challenge, mice fed transgenic Dp2 milk had decreased T-helper 2 (Th2) and increased T-helper 1 (Th1) responses in the airway compared with mice fed wild-type milk. Moreover, pre-treatment with transgenic Dp2 milk attenuated airway inflammation and decreased airway hyper-responsiveness. Conclusions This study provides new evidence that oral administration of transgenic milk containing the Dp2 allergen down-regulated and moderately protected against allergic airway inflammation. Milk from transgenic animals expressing allergens may have potential use in the prevention of allergic asthma. PMID:23763898

  17. Demonstration of the serum antibody to Epstein-Barr virus specific DNA polymerased (EBV-DP) from patients with nasopharyngeal carcinoma (NPC)

    Energy Technology Data Exchange (ETDEWEB)

    Tan, R.S.; Li, J.S.; Grill, S.; Nutter, L.M.; Cheng, Y.C.

    1986-03-05

    Raji cells, an EBV genome carrying and nonproducer cell line, treated with tetradecanoyl-phorbol-13-acetate (TPA) and n-butyrate could induce a special DNA polymerase which has properties that are similar to the EBV-DP induced by TPA in P/sub 3/HR-I cells, an EBV producer cell line. Since EBV was found to have a strong association with NPC, and antibodies against EBV proteins or enzymes were found in high levels in sera from these patients, the possible presence of serum antibody against EBV-DP was examined. The serum titer of antibody to EBV-DP was found to have 190 +/- 84 units/ml serum (mean +/- S.D.) in 48 sera from patients with NPC. The titer in 52 healthy donors was 31.4 +/- 28 unit/ml serum (p < 0.01). The antibody was found to be associated with the IgG but not the IgA fraction. The antibody titers against EBV-DP were not correlated with the titer against EBV-DNase or VCA-IgA. Whether the antibody observed is against an EBV-DP core protein or its stimulating protein, as demonstrated by this laboratory previously, is still being investigated. This study demonstrated the high frequency and high titer of antibody against EBV-DP in serum from patients with NPC, and suggested the potential of utilizing this antibody titer to compliment other methods for the early diagnosis or prognosis of NPC.

  18. Defense Spending and the Economy

    Science.gov (United States)

    1983-12-07

    the first resolution. Our forecast projects continued growth in the economy and moderate inflation for one or possibly two years, despite federal...than provided in the resolution. Additional emphasis on defense would, of course, promote defense-intensive sectors of the economy at the expense of...others, but CBO believes the economy could accommodate such shifts without significant adverse effects on macroeconomic variables such as employment

  19. Theater Missile Defense Integration Issues

    Science.gov (United States)

    1993-06-01

    high endoatmospheric defense interceptor (HEDI) proposed t earlier. EADTB. Extended Air Defense Test Bed. A computer-based analysis center for...for attacking deeper elements of an aggressors’s ground forces. Known in NATO as Follow-on Force Attack ( FOFA ). JSTARS. Joint surveillance target...AFIA/INKS ATTN. INKS AFIS/INT ATTN: INT AIR hORCE CTR FOR STUDIES & ANALYSIS ATTN: AFSAA/SAKI 9 Dist-1 w^mmmm mmmm^-mmmemH

  20. National Coastal Mapping Program

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — The U. S. Army Corps of Engineers (USACE) National Coastal Mapping Program (NCMP) is designed to provide high-resolution elevation and imagery data along U.S....