WorldWideScience

Sample records for deciphering universal extra

  1. Romanians decipher the Universe

    CERN Multimedia

    Balan, Sorin

    2007-01-01

    We are at the European Nuclear Research Center, the greatest partcile accelerator in the world. Approximately 50 people work here. Thanks to them, Romania can be proud of taking part in the greatest experiment in the world that tries to find an explanation for the ofrmation of the Universe. (1,5 page)

  2. Phenomenology of universal extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Kyoungchul; Matchev, Konstantin T.; /Florida U.

    2006-10-01

    In this proceeding, the phenomenology of Universal Extra Dimensions (UED), in which all the Standard Model fields propagate, is explored. We focus on models with one universal extra dimension, compactified on an S{sub 1}/Z{sub 2} orbifold. We revisit calculations of Kaluza-Klein (KK) dark matter without an assumption of the KK mass degeneracy including all possible coannihilations. We then contrast the experimental signatures of low energy supersymmetry and UED.

  3. Reviews in modern astronomy, deciphering the universe through spectroscopy

    CERN Document Server

    von Berlepsch, Regina

    2011-01-01

    This 22nd volume in the series contains 15 invited reviews and highlight contributions from outstanding speakers presented during the 2009 annual meeting of the Astronomical Society on the subject of ""Deciphering the Universe through Spectroscopy"", held in Potsdam, Germany. Topics range from the measurements of magnetic fields on the surface of the sun via detailed measurements of abundances in stellar atmospheres to the kinematics of the universe at its largest scales. The result is a systematic overview of the latest astronomical and cosmological research.

  4. Higgs Phenomenology of Minimal Universal Extra Dimensions

    Directory of Open Access Journals (Sweden)

    Kakizaki Mitsuru

    2012-06-01

    Full Text Available The minimal model of Universal Extra Dimensions (MUED is briefly reviewed. We explain how the cross-sections for Higgs production via gluon fusion and decay into photons are modified, relative the the Standard Model (SM values, by KK particles running in loops, leading to an enhancement of the gg → h → γγ and gg → h → W+W− cross-sections. ATLAS and CMS searches for the SM Higgs in these channels are reinterpreted in the context of MUED and used to place new limits on the MUED parameter space. Only a small region of between 1 and 3 GeV around mh = 125 GeV for 500 GeV < R−1 < 1600 GeV remains open at the 95 % confidence level.

  5. Higgs Pair Production in Models with Universal Extra Dimensions

    CERN Document Server

    de Sandes, Hiroshi

    2007-01-01

    In this letter we study the process of gluon fusion into a pair of Higgs bosons in a model with one universal extra dimension. We find that the contributions from the extra top quark Kaluza-Klein excitations lead to a Higgs pair production cross section that can be significantly altered compared to the Standard Model value for small values of the compactification scale.

  6. Scale Factor in Very Early Universe with the Extra Dimensions

    CERN Document Server

    Mohsenzadeh, M

    2010-01-01

    The main goal of this paper is presentation an expanding scenario of 5-dimensional space-time in the very early universe. We introduce the 5-dimensional generalized FRW metric and obtain the evolution of the bulk scale factor with space-like and time-like extra dimensions. It is shown that, additional space-like dimensions can produce an exponentially expansion for the bulk scale factor under repulsive strong gravitational force in the empty very early universe with the extra dimension.

  7. University Extra-Mural Studies and Extension Outreach: Incompatibilities

    Science.gov (United States)

    Rogers, Alan

    2014-01-01

    The argument of this paper is that--within a wide range of university responses to the challenge of outreach--there grew up in the extra-mural or adult education departments of many UK universities an alternative epistemological paradigm to the older and more traditional extension programmes. This paradigm threatened the extension approach and has…

  8. Nonminimal universal extra dimensional model confronts Bs→μ+μ-

    Science.gov (United States)

    Datta, Anindya; Shaw, Avirup

    2016-03-01

    The addition of boundary localized kinetic and Yukawa terms to the action of a five-dimensional Standard Model would nontrivially modify the Kaluza-Klein spectra and some of the interactions among the Kaluza-Klein excitations compared to the minimal version of this model, in which these boundary terms are not present. In the minimal version of this framework, known as the universal extra dimensional model, special assumptions are made about these unknown, beyond the cutoff contributions to restrict the number of unknown parameters of the theory to be minimum. We estimate the contribution of Kaluza-Klein modes to the branching ratios of Bs (d )→μ+μ- in the framework of the nonminimal universal extra dimensional model, at one-loop level. The results have been compared to the experimental data to constrain the parameters of this model. From the measured decay branching ratio of Bs→μ+μ- (depending on the values of boundary localized parameters), the lower limit on R-1 can be as high as 800 GeV. We have briefly reviewed the bounds on nonminimal universal extra dimensional parameter space coming from electroweak precision observables. The present analysis (Bs→μ+μ-) has ruled out new regions of parameter space in comparison to the analysis of electroweak data. We have revisited the bound on R-1 in the universal extra dimensional model, which came out to be 454 GeV. This limit on R-1 in the universal extra dimensional framework is not as competitive as the limits derived from the consideration of relic density or Standard Model Higgs boson production and decay to W+W-. Unfortunately, the Bd→μ+μ- decay branching ratio would not set any significant limit on R-1 in a minimal or nonminimal universal extra dimensional model.

  9. Signals of universal extra dimension at the international linear collider

    Indian Academy of Sciences (India)

    Biplob Bhattacherjee

    2007-11-01

    In the minimal universal extra dimension model, single production of = 2 gauge bosons provides a unique discriminating feature from supersymmetry. We discuss how the proposed international linear collider can act as a = 2 factory, much in the same vein as LEP.

  10. Universal Extra Dimension models with right-handed neutrinos

    CERN Document Server

    Matsumoto, Shigeki; Senami, Masato; Yamanaka, Masato

    2008-01-01

    Relic abundance of dark matter is investigated in the framework of universal extra dimension (UED) models with right-handed neutrinos. These models are free from the KK graviton problem in the minimal UED model. The first KK particle of the right-handed neutrino is a dark matter candidate in this framework. When ordinary neutrino masses are large enough such as the degenerate mass spectrum case, the dark matter relic abundance can increase significantly. The scale of the extra dimension consistent with cosmological observations can be 500 GeV in the minimal setup of UED models with right-handed neutrinos.

  11. Exploring the Universal Extra Dimension at the LHC

    CERN Document Server

    Bhattacharyya, Gautam; Majee, Swarup Kumar; Raychaudhuri, Amitava

    2009-01-01

    Besides supersymmetry, the other prime candidate of physics beyond the standard model (SM), crying out for verification at the CERN Large Hadron Collider (LHC), is extra-dimension. To hunt for effects of Kaluza-Klein (KK) excitations of known fermions and bosons is very much in the agenda of the LHC. These KK states arise when the SM particles penetrate in the extra space-like dimension(s). In this paper, we consider a 5d scenario, called `Universal Extra Dimension', where the extra space coordinate, compactified on an orbifold $S^1/Z_2$, is accessed by {\\em all} the particles. The KK number ($n$) is conserved at all tree level vertices. This entails the production of KK states in pairs and renders the lightest KK particle stable, which leaves the detector carrying away missing energy. The splitting between different KK flavors is controlled by the zero mode masses and the bulk- and brane-induced one-loop radiative corrections. We concentrate on the production of an $n=1$ KK electroweak gauge boson in associa...

  12. Dark Matter and Collider Phenomenology of Universal Extra Dimensions

    CERN Document Server

    Hooper, D; Hooper, Dan; Profumo, Stefano

    2007-01-01

    We review the phenomenology of models with flat, compactified extra dimensions where all of the Standard Model fields are allowed to propagate in the bulk, known as Universal Extra Dimensions (UED). UED make for an interesting TeV-scale physics scenario, featuring a tower of Kaluza-Klein (KK) states approximately degenerate in mass at the scale set by the inverse size of the compactification radius. KK parity, the four-dimensional remnant of momentum conservation in the extra dimensions, implies two basic consequences: (1) contributions to Standard Model observables arise only at loop level, and KK states can only be pair-produced at colliders, and (2) the lightest KK particle (LKP) is stable, providing a suitable particle dark matter candidate. After a theoretical overview on extra dimensional models, and on UED in particular, we introduce the model particle spectrum and the constraints from precision electroweak tests and current colliders data. We then give a detailed overview of the LKP dark matter phenom...

  13. Lepton Universality Test of Extra Leptons using Hadron Decay

    CERN Document Server

    Endo, Motoi

    2014-01-01

    We study the flavor universality of the lepton couplings with the W and Z bosons. Currently, it is constrained by the electroweak precision observables. We focus on the leptonic decay of the pion. It is shown that the decay is expected to have a comparable or better sensitivity to the lepton-flavor universality in the near future. Furthermore, it provides a complementary information in determining the Wlnu couplings without assuming new physics models. This result is applied to a model of the extra lepton.

  14. Emergent Yang-Mills Theories from Universal Extra Dimensions

    CERN Document Server

    Chkareuli, J L

    2016-01-01

    We study emergent Yang-Mills theories which could origin from universal extra dimensions. Particularly, some vector field potential terms or polynomial vector field constraints introduced into five-dimensional non-Abelian gauge theory is shown to lead to spontaneous violation of an underlying spacetime symmetry and generate vector pseudo-Goldstone modes as conventional 4D gauge boson candidates. As a special signature, apart from conventional gauge couplings, there appear an infinite number of the properly suppressed direct multi-boson (multi-photon in particular) interaction couplings in emergent Yang-Mills theories whose observation could shed light on their high-dimensional nature. Moreover, in these theories an internal symmetry is also appeared spontaneously broken to its diagonal subgroups. This breaking origins from the extra vector field components playing a role of some adjoint scalar field multiplet in the 4D spacetime. So, one naturally has the Higgs effect without a specially introduced scalar fie...

  15. Search for universal extra dimensions in ppbar collisions

    Energy Technology Data Exchange (ETDEWEB)

    Abazov, Victor Mukhamedovich; /Dubna, JINR; Abbott, Braden Keim; /Oklahoma U.; Acharya, Bannanje Sripath; /Tata Inst.; Adams, Mark Raymond; /Illinois U., Chicago; Adams, Todd; /Florida State U.; Alexeev, Guennadi D.; /Dubna, JINR; Alkhazov, Georgiy D.; /St. Petersburg, INP; Alton, Andrew K.; /Michigan U. /Augustana Coll., Sioux Falls; Alverson, George O.; /Northeastern U.; Aoki, Masato; /Fermilab; Askew, Andrew Warren; /Florida State U. /Stockholm U.

    2011-12-01

    We present a search for Kaluza-Klein (KK) particles predicted by models with universal extra dimensions (UED) using a data set corresponding to an integrated luminosity of 7.3 fb{sup -1}, collected by the D0 detector at a p{bar p} center of mass energy of 1.96 TeV. The decay chain of KK particles can lead to a final state with two muons of the same charge. This signature is used to set a lower limit on the compactification scale of R{sup -1} > 260 GeV in a minimal UED model.

  16. The Standard Model with one universal extra dimension

    Indian Academy of Sciences (India)

    A Cordero-Cid; M Gómez-Bock; H Novales-Sánchez; J J Toscano

    2013-03-01

    Effects of universal extra dimensions on Standard Model observables first arise at the one-loop level. The quantization of this class of theories is therefore essential in order to perform predictions. A comprehensive study of the $SU_{C}(3) × SU_{L}(2) × U_{Y}(1)$ Standard Model defined in a space-time manifold with one universal extra dimension, compactified on the oribifold $S^{1}/Z_{2}$, is presented. The fact that the four-dimensional Kaluza–Klein theory is subjected to two types of gauge transformations is stressed and its quantization under the basis of the BRST symmetry discussed. $A SU_{C}(3) × SU_{L}(2) × U_{Y}(1)$-covariant gauge-fixing procedure for the Kaluza–Klein excitations is introduced. The connection between gauge and mass eigenstate fields is established in an exact way. An exhaustive list of the explicit expressions for all physical couplings induced by the Yang–Mills, Currents, Higgs, and Yukawa sectors is presented. The one-loop renormalizability of the standard Green’s functions, which implies that the Standard Model observables do not depend on a cut-off scale, is stressed.

  17. Signals of Two Universal Extra Dimensions at the LHC

    CERN Document Server

    Burdman, G; Spehler, D

    2016-01-01

    Extensions of the standard model with universal extra dimensions are interesting both as phenomenological templates as well as model-building fertile ground. For instance, they are one the prototypes for theories exhibiting compressed spectra, leading to difficult searches at the LHC since the decay products of new states are soft and immersed in a large standard model background. Here we study the phenomenology at the LHC of theories with two universal extra dimensions. We obtain the current bound by using the production of second level excitations of electroweak gauge bosons decaying to a pair of leptons and study the reach of the LHC Run~II in this channel. We also introduce a new channel originating in higher dimensional operators and resulting in the single production of a second level quark excitation. Its subsequent decay into a hard jet and lepton pair resonance would allow the identification of a more model-specific process, unlike the more generic vector resonance signal. We show that the sensitivit...

  18. Universal extra dimensions and Z->b bar-b

    CERN Document Server

    Oliver, J F; Santamaría, A

    2003-01-01

    We study, at the one loop level, the dominant contributions from a single universal extra dimension to the process (Z\\to b\\bar{b}). By resorting to the gaugeless limit of the theory we explain why the result is expected to display a strong dependence on the mass of the top-quark, not identified in the early literature. A detailed calculation corroborates this expectation, giving rise to a lower bound for the compactification scale which is comparable to that obtained from the $\\rho$ parameter. An estimate of the subleading corrections is furnished, together with a qualitative discussion on the difference between the present results and those derived previously for the non-universal case.

  19. Emergent Yang-Mills theories from universal extra dimensions

    Science.gov (United States)

    Chkareuli, J. L.; Kepuladze, Z.

    2017-02-01

    We study emergent Yang-Mills theories which could origin from universal extra dimensions. Particularly, some vector field potential terms or polynomial vector field constraints introduced into five-dimensional (5D) non-Abelian gauge theory is shown to lead to spontaneous violation of an underlying spacetime symmetry and generate vector pseudo-Goldstone modes as conventional four-dimensional (4D) gauge boson candidates. As a special signature, apart from conventional gauge couplings, there appear an infinite number of the properly suppressed direct multi-boson (multi-photon in particular) interaction couplings in emergent Yang-Mills theories whose observation could shed light on their high-dimensional nature. Moreover, in these theories, an internal symmetry also appeared spontaneously broken to its diagonal subgroups. This breaking originates from the extra vector field components playing the role of some adjoint scalar field multiplet in the 4D spacetime. So, one naturally has the Higgs effect without a specially introduced scalar field multiplet. Remarkably, when applied to Grand Unified Theories (GUTs), this results in an automatic breakdown of emergent GUTs down to the Standard Model (SM) just at the 5D Lorentz violation scale M.

  20. Current LHC constraints on minimal universal extra dimensions

    Science.gov (United States)

    Deutschmann, Nicolas; Flacke, Thomas; Kim, Jong Soo

    2017-08-01

    In this letter, we present LHC limits on the minimal universal extra dimension (MUED) model from LHC Run 1 data and current limits from searches of the ongoing Run 2. Typical collider signals of the Kaluza-Klein (KK) states mimic generic degenerate supersymmetry (SUSY) missing transverse momentum signatures since the KK particles cascade decay into jets, leptons and the lightest KK particle which is stable due to KK parity and evades detection. We test the parameter space against a large number of supersymmetry based missing energy searches implemented in the public code CheckMATE. We demonstrate the complementarity of employing various searches which target a large number of final state signatures, and we derive the most up to date limits on the MUED parameter space from 13 TeV SUSY searches.

  1. Gamma ray lines from a universal extra dimension

    Energy Technology Data Exchange (ETDEWEB)

    Bertone, Gianfranco; Jackson, C. B.; Shaughnessy, Gabe; Tait, Tim M.P.; Vallinotto, Alberto

    2012-03-01

    Indirect Dark Matter searches are based on the observation of secondary particles produced by the annihilation or decay of Dark Matter. Among them, gamma-rays are perhaps the most promising messengers, as they do not suffer deflection or absorption on Galactic scales, so their observation would directly reveal the position and the energy spectrum of the emitting source. Here, we study the detailed gamma-ray energy spectrum of Kaluza--Klein Dark Matter in a theory with 5 Universal Extra Dimensions. We focus in particular on the two body annihilation of Dark Matter particles into a photon and another particle, which produces monochromatic photons, resulting in a line in the energy spectrum of gamma rays. Previous calculations in the context of the five dimensional UED model have computed the line signal from annihilations into \\gamma \\gamma, but we extend these results to include \\gamma Z and \\gamma H final states. We find that these spectral lines are subdominant compared to the predicted \\gamma \\gamma signal, but they would be important as follow-up signals in the event of the observation of the \\gamma \\gamma line, in order to distinguish the 5d UED model from other theoretical scenarios.

  2. Global Fits of the Minimal Universal Extra Dimensions Scenario

    Energy Technology Data Exchange (ETDEWEB)

    Bertone, Gianfranco; /Zurich U. /Paris, Inst. Astrophys.; Kong, Kyoungchul; /SLAC /Kansas U.; de Austri, Roberto Ruiz; /Valencia U., IFIC; Trotta, Roberto; /Imperial Coll., London

    2012-06-22

    In theories with Universal Extra-Dimensions (UED), the {gamma}{sub 1} particle, first excited state of the hypercharge gauge boson, provides an excellent Dark Matter (DM) candidate. Here we use a modified version of the SuperBayeS code to perform a Bayesian analysis of the minimal UED scenario, in order to assess its detectability at accelerators and with DM experiments. We derive in particular the most probable range of mass and scattering cross sections off nucleons, keeping into account cosmological and electroweak precision constraints. The consequences for the detectability of the {gamma}{sub 1} with direct and indirect experiments are dramatic. The spin-independent cross section probability distribution peaks at {approx} 10{sup -11} pb, i.e. below the sensitivity of ton-scale experiments. The spin-dependent cross-section drives the predicted neutrino flux from the center of the Sun below the reach of present and upcoming experiments. The only strategy that remains open appears to be direct detection with ton-scale experiments sensitive to spin-dependent cross-sections. On the other hand, the LHC with 1 fb{sup -1} of data should be able to probe the current best-fit UED parameters.

  3. Global Fits of the Minimal Universal Extra Dimensions Scenario

    Energy Technology Data Exchange (ETDEWEB)

    Bertone, Gianfranco; /Zurich U. /Paris, Inst. Astrophys.; Kong, Kyoungchul; /SLAC /Kansas U.; de Austri, Roberto Ruiz; /Valencia U., IFIC; Trotta, Roberto; /Imperial Coll., London

    2012-06-22

    In theories with Universal Extra-Dimensions (UED), the {gamma}{sub 1} particle, first excited state of the hypercharge gauge boson, provides an excellent Dark Matter (DM) candidate. Here we use a modified version of the SuperBayeS code to perform a Bayesian analysis of the minimal UED scenario, in order to assess its detectability at accelerators and with DM experiments. We derive in particular the most probable range of mass and scattering cross sections off nucleons, keeping into account cosmological and electroweak precision constraints. The consequences for the detectability of the {gamma}{sub 1} with direct and indirect experiments are dramatic. The spin-independent cross section probability distribution peaks at {approx} 10{sup -11} pb, i.e. below the sensitivity of ton-scale experiments. The spin-dependent cross-section drives the predicted neutrino flux from the center of the Sun below the reach of present and upcoming experiments. The only strategy that remains open appears to be direct detection with ton-scale experiments sensitive to spin-dependent cross-sections. On the other hand, the LHC with 1 fb{sup -1} of data should be able to probe the current best-fit UED parameters.

  4. A Way to the Dark Side of the Universe through Extra Dimensions

    CERN Document Server

    Gu, J A

    2002-01-01

    As indicated by Einstein's general relativity, matter and geometry are two faces of a single nature. In our point of view, extra dimensions, as a member of the {\\em geometry face}, will be treated as a part of the {\\em matter face} when they are beyond our poor vision, thereby providing dark energy sources effectively. The geometrical structure and the evolution pattern of extra dimensions therefore may play an important role in cosmology. Various possible impacts of extra dimensions on cosmology are investigated. In one way, the evolution of homogeneous extra dimensions may contribute to dark energy, driving the accelerating expansion of the universe. In the other way, both the energy perturbations in the ordinary three-space, combined with homogeneous extra dimensions, and the inhomogeneities in the extra space may contribute to dark matter. In this paper we wish to sketch the basic idea and show how extra dimensions may lead to the dark side of our universe.

  5. Casimir Effect at Finite Temperature in the Presence of Compactified Universal Extra Dimensions

    Institute of Scientific and Technical Information of China (English)

    CHENG Hong-Bo

    2005-01-01

    @@ We analyse the Casimir effect for parallel plates atfinite temperature in the presence of compactified universal extra dimensions and analytically show the thermal corrections to the effect in detail. The Casimir effect for different sizes of universal extra dimensions is investigated to test the five-dimensional Kaluza-Klein theory.

  6. Stability of extra dimensions in the inflating early universe

    Energy Technology Data Exchange (ETDEWEB)

    Wieck, Clemens

    2015-08-15

    Cosmic inflation is an attractive paradigm to explain the initial conditions of the universe. It can be conveniently described by the dynamics of a single scalar field within N=1 supergravity. Due to the high energy scale during the inflationary epoch, which is favored by recent observations of the cosmic microwave background radiation, and the flatness of the inflaton potential it is necessary to consider inflation in the context of a UV-complete theory like string theory. To this end, we study the effects of moduli stabilization on inflation models in supergravity, focussing on Kahler moduli in type IIB string theory which govern the size of extra dimensions. For generic models of F-term inflation we calculate back-reaction terms by integrating out the moduli at a high energy scale. When the moduli are stabilized supersymmetrically, all effects decouple in the limit of very heavy moduli. The corrections, however, may be sizeable for realistic moduli masses above the Hubble scale and affect the predicted observables of many models like chaotic inflation and hybrid inflation. If, on the other hand, moduli stabilization entails spontaneous supersymmetry breaking, there are non-decoupling effects like soft mass terms for the inflaton. By the example of chaotic inflation we show that a careful choice of parameters and initial conditions is necessary to reconcile large-field inflation with popular moduli stabilization schemes like KKLT stabilization or the Large Volume Scenario. Furthermore, we study the interplay of moduli stabilization and D-term inflation. If inflation is driven by a constant Fayet-Iliopoulos term, the back-reaction decouples but the gravitino mass in the vacuum is surprisingly constrained. For a field-dependent Fayet-Iliopoulos term associated with an anomalous U(1) symmetry we discuss a number of obstructions to realizing inflation. Moreover, we propose a way to evade them using a new mechanism for supersymmetric moduli stabilization with world

  7. Probing universal extra dimension at the international linear collider

    Indian Academy of Sciences (India)

    Gautam Bhattacharyya

    2007-11-01

    We consider the UED scenario and study the detectability of the first KK electron-positron pair at the ILC. A few hundred GeV KK electron decays into a nearly degenerate KK photon, which carries away missing energy, and the standard electron. The mass splitting between the KK electron and KK photon is controlled by the bulk- and brane-induced radiative corrections. We look for the signal event + - + large missingenergy for $\\sqrt{s} = 1$ TeV and observe that with a few hundred fb-1 luminosity the signal can be deciphered from the standard model background. We briefly outline how the UED signals may be distinguished from the supersymmetric signals.

  8. Collider Implications of Multiple Non-Universal Extra Dimensions

    CERN Document Server

    Ghavri, R; Nandi, S

    2006-01-01

    We consider multiple TeV scale extra compact dimensions in an asymmetric string compactification scenario in which the SM gauge bosons can propagate into the TeV scale extra dimensions while the SM fermions are confined to the usual SM D3 brane. We calculate the contributions that the KK excitations of the gluons make to the multijet cross sections in proton proton collisions at the LHC energy. At very high pT, the dijet signal will either be enhanced significantly due to virtual g star exchanges or place a lower bound on the compactification scale of about 8 TeV. We find that the dijet signal is very sensitive to three parameters: the compactification scale, the string scale, and the number of extra dimensions. Thus, although the dijet signal is much more sensitive to KK effects, the dijet signal alone does not provide sufficient information to deduce the number of extra dimensions nor the compactification scale. However, the three jet signal, which is not sensitive to the string scale, can be analyzed in co...

  9. A theory of extra radiation in the Universe

    Energy Technology Data Exchange (ETDEWEB)

    Nakayama, Kazunori, E-mail: kazunori@post.kek.j [Theory Center, KEK, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Takahashi, Fuminobu [Institute for the Physics and Mathematics of the Universe, University of Tokyo, Kashiwa 277-8568 (Japan); Yanagida, Tsutomu T. [Institute for the Physics and Mathematics of the Universe, University of Tokyo, Kashiwa 277-8568 (Japan); Department of Physics, University of Tokyo, Tokyo 113-0033 (Japan)

    2011-03-14

    Recent cosmological observations, such as the measurement of the primordial {sup 4}He abundance, CMB, and large scale structure, give preference to the existence of extra radiation component, {Delta}N{sub {nu}>}0. The extra radiation may be accounted for by particles which were in thermal equilibrium and decoupled before the big bang nucleosynthesis. Broadly speaking, there are two possibilities: (1) there are about 10 particles which have very weak couplings to the standard model particles and decoupled much before the QCD phase transition; (2) there is one or a few light particles with a reasonably strong coupling to the plasma and it decouples after the QCD phase transition. Focusing on the latter case, we find that a light chiral fermion is a suitable candidate, which evades astrophysical constraints. Interestingly, our scenario predicts a new gauge symmetry at TeV scale, and therefore may be confirmed at the LHC. As a concrete example, we show that such a light fermion naturally appears in the E{sub 6}-inspired GUT.

  10. About Extra-Curricular Activities of The University Graduate – Student’s Viewpoint

    Directory of Open Access Journals (Sweden)

    Ivanova Veronica

    2017-01-01

    Full Text Available Extra-curricular activity of modern youth, including university students, is considered to reduce. Students are thought to demonstrate consumer’s attitude, unwillingness to participate in any social activity, and as a result, the level of soft skills acquired by university students is decreasing. The study of social activity of 100 Bachelor graduates from TPU, including the program “Electrical engineering”, indicated the role of the university in creation of conditions for competence development during training of students according to individual educational trajectory and development of their social (extra-curricular activity.

  11. Extra structure and the universal construction for the Witten-Reshetikhin-Turaev TQFT

    CERN Document Server

    Gilmer, Patrick M

    2012-01-01

    A TQFT is a functor from a cobordism category to the category of vector spaces, satisfying certain properties. An important property is that the vector spaces should be finite dimensional. For the WRT TQFT, the relevant 2+1-cobordism category is built from manifolds which are equipped with an extra structure such as a p_1-structure, or an extended manifold structure. The purpose of this paper is to explain that without this extra structure, one would not get finite dimensionality. To this purpose, we perform the universal construction of [BHMV95] without the extra structure and show that the resulting quantization functor assigns an infinite dimensional vector space to the torus.

  12. Thermal relic abundance of the lightest Kaluza-Klein particle in phenomenological universal extra dimension models

    CERN Document Server

    Ishigure, Yoshiaki; Santa, Akiteru

    2016-01-01

    Universal extra dimension models with Kaluza-Klein parity provide us excellent candidates for dark matter. We consider phenomenological universal extra dimension models where the Kaluza-Klein (KK) mass spectrum is different from that of the minimal universal extra dimension model, and compute the thermal relic abundance of the first KK mode of the photon taking into account the production of second KK particles. It is pointed out that its thermal relic abundance depends significantly on the mass degeneracy between the KK-photon and other KK particles because of considerable coannihilation effects. The cosmologically favored compactification scale is shown to range from around 1 TeV to a few TeV even in the cases where one of the first KK particles is tightly degenerate with the first KK photon in mass.

  13. Effects of non-minimal Universal Extra Dimension on $B\\rightarrow X_s\\gamma$

    CERN Document Server

    Datta, Anindya

    2016-01-01

    We estimate contributions from Kaluza-Klein excitations of third generation quarks and gauge bosons to the branching ratio of $B\\rightarrow X_s\\gamma$ decay process in 5-Dimensional Universal Extra Dimensional scenario with non-vanishing boundary localised terms. This model is conventionally known as non-minimal Universal Extra Dimensional model. We have derived the lower limit on the size of the extra dimension by comparing our theoretical estimation of the branching ratio which includes next-to-next-to leading order QCD corrections with its experimentally measured value. Coefficients of the boundary localised terms have also been constrained. 95 \\% C.L. lower limit on inverse of radius of compactification ($R^{-1}$) can be as large as 670 GeV for some choice of the value of coefficients of boundary localised terms.

  14. Different Prospects of the Universe Depending on Dark Energy and/or a New Kind of Extra Dimension

    OpenAIRE

    Feng, Sheng-Fei; Huang, Yong-Chang; Xin LIU; Zhao, Ying-Jie

    2016-01-01

    Generally making the cosmological scale factor $R$ be a function of the coordinate of the extra dimension $\\sigma $ that is also a function of time $t$, we achieve a new kind of cosmic acceleration mechanism depending on extra dimension. We give the constraints on $\\sigma $ under four different prospects of the universe, and indicate that dark energy is not required for both the small extra dimension and the accelerating expansion of our universe. This results in this paper show that the acce...

  15. p-brane production in Fat brane or Universal extra dimension scenario

    CERN Document Server

    Cheung, K; Cheung, Kingman; Chou, Chung-Hsien

    2002-01-01

    In models of large extra dimensions, the fundamental Planck scale can be as low as TeV. Thus, in hadronic collisions interesting objects like black holes, string balls, or $p$-branes can be produced. In scenarios of fat brane or universal extra dimensions, the SM particles are allowed to propagate in the extra spatial dimensions, which leads to the enhancement of production cross sections of black holes and $p$-branes. Especially, the ratio of $p$-brane cross section to the black hole cross section increases substantially, in comparison with the original confined scenario. The ratio can be as large as 105 (for the case $n=7,m=5=p=r=k$).

  16. Extra Dimensions and the Universal Suppression of Higgs Boson Observables at High Energy Colliders

    CERN Document Server

    Wells, J D

    2002-01-01

    Precision electroweak data suggests the existence of a light Standard Model Higgs boson. Its width is very narrow by an accident of the fermion mass hierarchies, and so slight perturbations to the theory induce dramatic changes in the phenomenology of direct Higgs boson production. Several theory ideas motivated by low-scale extra dimensions lead to a universal rate suppression of Higgs boson observables. The Tevatron and LHC will have difficulty accruing compelling evidence for small universal suppression of rate observables, and even more difficulty discerning the underlying cause. A high energy e+e- collider would have relatively little trouble.

  17. Noise perception in the workplace and auditory and extra-auditory symptoms referred by university professors.

    Science.gov (United States)

    Servilha, Emilse Aparecida Merlin; Delatti, Marina de Almeida

    2012-01-01

    To investigate the correlation between noise in the work environment and auditory and extra-auditory symptoms referred by university professors. Eighty five professors answered a questionnaire about identification, functional status, and health. The relationship between occupational noise and auditory and extra-auditory symptoms was investigated. Statistical analysis considered the significance level of 5%. None of the professors indicated absence of noise. Responses were grouped in Always (A) (n=21) and Not Always (NA) (n=63). Significant sources of noise were both the yard and another class, which were classified as high intensity; poor acoustic and echo. There was no association between referred noise and health complaints, such as digestive, hormonal, osteoarticular, dental, circulatory, respiratory and emotional complaints. There was also no association between referred noise and hearing complaints, and the group A showed higher occurrence of responses regarding noise nuisance, hearing difficulty and dizziness/vertigo, tinnitus, and earache. There was association between referred noise and voice alterations, and the group NA presented higher percentage of cases with voice alterations than the group A. The university environment was considered noisy; however, there was no association with auditory and extra-auditory symptoms. The hearing complaints were more evident among professors in the group A. Professors' health is a multi-dimensional product and, therefore, noise cannot be considered the only aggravation factor.

  18. Different Prospects of the Universe Depending on Dark Energy and/or a New Kind of Extra Dimension

    CERN Document Server

    Feng, Sheng-Fei; Liu, Xin; Zhao, Ying-Jie

    2016-01-01

    Generally making the cosmological scale factor R be a function of the coordinate of the extra dimension {\\sigma} that is also a function of time t, we achieve a new kind of cosmic acceleration mechanism depending on extra dimension, give the constraints on {\\sigma} under four different conditions, finally we achieve both the small extra dimension and the accelerating expansion of our universe not only needing dark energy, and the achieved results in this letter show that the accelerating expansion of our universe may come from both dark energy and the achieved new mechanism here, or the latter alone.

  19. Cosmological Constraints on Radion Evolution in the Universal Extra Dimension Model

    CERN Document Server

    Chan, K C

    2007-01-01

    The constraints on the radion evolution in the Universal Extra Dimension (UED) model from Cosmic Microwave Background (CMB) and Type Ia supernovae (SNe Ia) data are studied. In the UED model, where both the gravity and standard model fields can propagate in the extra dimensions, the evolution of the extra dimensional volume, the radion, induces variation of fundamental constants. We discuss the effects of variation of the relevant constants in the context of UED for CMB power spectrum and SNe Ia data. We then use the three-year WMAP data to constrain the radion evolution at z \\sim 1100, and the 2 \\sigma constraint on \\dot{\\rho} / \\rho_0 (\\rho is a function of the radion, to be defined in the text) is [ -8.8, 6.6] \\times 10 ^{-13} yr^-1. The SNe Ia gold sample yields a constraint on \\dot{\\rho} / \\rho_0, for redshift between 0 and 1, to be [-4.7, 14] \\times 10^{-13} yr^-1. Furthermore, the constraints from SNe Ia can be interpreted as bounds on the evolution QCD scale parameter, \\dot{\\Lambda}_{QCD} / \\Lambda_{Q...

  20. Search for Universal Extra Dimensions in p(p)over-bar Collisions

    Energy Technology Data Exchange (ETDEWEB)

    Abazov V. M.; Abbott B.; Acharya B. S.; Adams M.; Adams T.; Alexeev G. D.; Alkhazov G.; Alton A.; Alverson G.; Aoki M.; Askew A.; Asman B.; Atkins S.; Atramentov O.; Augsten K.; Avila C.; BackusMayes J.; Badaud F.; Bagby L.; Baldin B.; Bandurin D. V.; Banerjee S.; Barberis E.; Baringer P.; Barreto J.; Bartlett J. F.; Bassler U.; Bazterra V.; Bean A.; Begalli M.; Belanger-Champagne C.; Bellantoni L.; Beri S. B.; Bernardi G.; Bernhard R.; Bertram I.; Besancon M.; Beuselinck R.; Bezzubov V. A.; Bhat P. C.; Bhatia S.; Bhatnagar V.; Blazey G.; Blessing S.; Bloom K.; Boehnlein A.; Boline D.; Boos E. E.; Borissov G.; Bose T.; Brandt A.; Brandt O.; Brock R.; Brooijmans G.; Bross A.; Brown D.; Brown J.; Bu X. B.; Buehler M.; Buescher V.; Bunichev V.; Burdin S.; Burnett T. H.; Buszello C. P.; Calpas B.; Camacho-Perez E.; Carrasco-Lizarraga M. A.; Casey B. C. K.; Castilla-Valdez H.; Chakrabarti S.; Chakraborty D.; Chan K. M.; Chandra A.; Chapon E.; Chen G.; Chevalier-Thery S.; Cho D. K.; Cho S. W.; Choi S.; Choudhary B.; Cihangir S.; Claes D.; Clutter J.; Cooke M.; Cooper W. E.; Corcoran M.; Couderc F.; Cousinou M-C; Croc A.; Cutts D.; Das A.; Davies G.; de Jong S. J.; De La Cruz-Burelo E.; Deliot F.; Demina R.; Denisov D.; Denisov S. P.; Desai S.; Deterre C.; DeVaughan K.; Diehl H. T.; Diesburg M.; Ding P. F.; Dominguez A.; Dorland T.; Dubey A.; Dudko L. V.; Duggan D.; Duperrin A.; Dutt S.; Dyshkant A.; Eads M.; Edmunds D.; Ellison J.; Elvira V. D.; Enari Y.; Evans H.; Evdokimov A.; Evdokimov V. N.; Facini G.; Ferbel T.; Fiedler F.; Filthaut F.; Fisher W.; Fisk H. E.; Fortner M.; Fox H.; Fuess S.; Garcia-Bellido A.; Garcia-Guerra G. A.; Gavrilov V.; Gay P.; Geng W.; Gerbaudo D.; Gerber C. E.; Gershtein Y.; Ginther G.; Golovanov G.; Goryachev V. N.; Goussiou A.; Grannis P. D.; Greder S.; Greenlee H.; Greenwood Z. D.; Gregores E. M.; Grenier G.; Gris Ph; Grivaz J-F; Grohsjean A.; Gruenendahl S.; Gruenewald M. W.; Guillemin T.; Gutierrez G.; Gutierrez P.; Haas A.; Hagopian S.; Haley J.; Han L.; Harder K.; Harel A.; Hauptman J. M.; Hays J.; Head T.; Hebbeker T.; Hedin D.; Hegab H.; Heinson A. P.; Heintz U.; Hensel C.; Heredia-De La Cruz I.; Herner K.; Hesketh G.; Hildreth M. D.; Hirosky R.; Hoang T.; Hobbs J. D.; Hoeneisen B.; Hohlfeld M.; Hubacek Z.; Hynek V.; Iashvili I.; Ilchenko Y.; Illingworth R.; Ito A. S.; Jabeen S.; Jaffre M.; Jamin D.; Jayasinghe A.; Jesik R.; Johns K.; Johnson M.; Jonckheere A.; Jonsson P.; Joshi J.; Jung A. W.; Juste A.; Kaadze K.; Kajfasz E.; Karmanov D.; Kasper P. A.; Katsanos I.; Kehoe R.; Kermiche S.; Khalatyan N.; Khanov A.; Kharchilava A.; Kharzheev Y. N.; Kohli J. M.; Kozelov A. V.; Kraus J.; Kulikov S.; Kumar A.; Kupco A.; Kurca T.; Kuzmin V. A.; Lammers S.; Landsberg G.; Lebrun P.; Lee H. S.; Lee S. W.; Lee W. M.; Lellouch J.; Li H.; Li L.; Li Q. Z.; Lietti S. M.; Lim J. K.; Lincoln D.; Linnemann J.; Lipaev V. V.; Lipton R.; Liu Y.; Lobodenko A.; Lokajicek M.; de Sa R. Lopes; Lubatti H. J.; Luna-Garcia R.; Lyon A. L.; Maciel A. K. A.; Mackin D.; Madar R.; Magana-Villalba R.; Malik S.; Malyshev V. L.; Mansour J.; Maravin Y.; Martinez-Ortega J.; McCarthy R.; McGivern C. L.; Meijer M. M.; Melnitchouk A.; Menezes D.; Mercadante P. G.; Merkin M.; Meyer A.; Meyer J.; et al.

    2012-03-30

    We present a search for Kaluza-Klein (KK) particles predicted by models with universal extra dimensions (UED) using a data set corresponding to an integrated luminosity of 7.3 fb{sup -1}, collected by the D0 detector at a p{bar p} center-of-mass energy of 1.96 TeV. The decay chain of KK particles can lead to a final state with two muons of the same charge. This signature is used to set a lower limit on the compactification scale of R{sup -1} > 260 GeV in a minimal UED model.

  1. Bounds on universal extra dimension from LHC run I and II data

    Science.gov (United States)

    Choudhury, Debajyoti; Ghosh, Kirtiman

    2016-12-01

    We discuss the collider bounds on minimal Universal Extra Dimension (mUED) model from LHC Run-I and II data. The phenomenology of mUED is determined by only two parameters namely, the compactification scale (R-1) of the extra dimension and cutoff scale (Λ) of the theory. The characteristic feature of mUED is the occurrence of nearly degenerate mass spectrum for the Kaluza-Klein (KK) particles and hence, soft leptons, soft jets at the collider experiments. The degree of degeneracy of KK-mass spectrum crucially depends on Λ. The strongest direct bound on R-1 (∼ 950GeV for large Λ) arises from a search for a pair of soft dimuons at the Large Hadron Collider (LHC) experiment with 8 TeV center-of-mass energy and 20 fb-1 integrated luminosity. However, for small Λ and hence, small splitting within the first KK-level, the bounds from the dimuon channel are rather weak. On the other hand, the discovery of 126 GeV Higgs boson demands small Λ to prevent the scalar potential form being unbounded from below. We discuss LHC monojet searches as a probe of low Λ region of mUED parameter space. We also compute bounds on the mUED parameter space from 13 TeV multijets results.

  2. Bounds on Universal Extra Dimension from LHC Run I and II data

    CERN Document Server

    Choudhury, Debajyoti

    2016-01-01

    We discuss the collider bounds on minimal Universal Extra Dimension (mUED) model from LHC Run-I and II data. The phenomenology of mUED is determined by only two parameters namely, the compactification scale ($R^{-1}$) of the extra dimension and cutoff scale ($\\Lambda$) of the theory. The characteristic feature of mUED is the occurrence of nearly degenerate mass spectrum for the Kaluza-Klein (KK) particles and hence, soft leptons, soft jets at the collider experiments. The degree of degeneracy of KK-mass spectrum crucially depends on $\\Lambda$. The strongest direct bound on $R^{-1}$ ($\\sim $950 GeV for large $\\Lambda$) arises from a search for a pair of soft dimuons at the Large Hadron Collider (LHC) experiment with 8 TeV center-of-mass energy and $20~{\\rm fb}^{-1}$ integrated luminosity. However, for small $\\Lambda$ and hence, small splitting within the first KK-level, the bounds from the dimuon channel is rather weak. On the other hand, the discovery of 126 GeV Higgs boson demands small $\\Lambda$ to prevent ...

  3. Distinguishing Supersymmetry From Universal Extra Dimensions or Little Higgs Models With Dark Matter Experiments

    CERN Document Server

    Hooper, D; Hooper, Dan; Zaharijas, Gabrijela

    2007-01-01

    There are compelling reasons to think that new physics will appear at or below the TeV-scale. It is not known what form this new physics will take, however. Although The Large Hadron collider is very likely to discover new particles associated with the TeV-scale, it may be difficult for it to determine the nature of those particles, whether superpartners, Kaluza-Klein modes or other states. In this article, we consider how direct and indirect dark matter detection experiments may provide information complementary to hadron colliders, which can be used to discriminate between supersymmetry, models with universal extra dimensions, and Little Higgs theories. We find that, in many scenarios, dark matter experiments can be effectively used to distinguish between these possibilities.

  4. Classical and Quantum Cosmology of an Accelerating Model Universe with Compactification of Extra Dimensions

    CERN Document Server

    Darabi, F

    2009-01-01

    We study a $(4+D)$-dimensional Kaluza-Klein cosmology with a Robertson-Walker type metric having two scale factors $a$ and $R$, corresponding to $D$-dimensional internal space and 4-dimensional universe, respectively. By introducing an exotic matter in the form of perfect fluid with an special equation of state, as the space-time part of the higher dimensional energy-momentum tensor, a four dimensional effective decaying cosmological term appears as $\\lambda \\sim R^{-m}$ with $0 \\leq m\\leq 2$, playing the role of an evolving dark energy in the universe. By taking $m=2$, which has some interesting implications in reconciling observations with inflationary models and is consistent with quantum tunneling, the resulting Einstein's field equations yield the exponential solutions for the scale factors $a$ and $R$. These exponential behaviors may account for the dynamical compactification of extra dimensions and the accelerating expansion of the 4-dimensional universe in terms of Hubble parameter, $H$. The accelerat...

  5. The second Kaluza-Klein neutral Higgs bosons in the minimal Universal Extra Dimension model

    CERN Document Server

    Chang, Sanghyeon; Song, Jeonghyeon

    2011-01-01

    Loop-induced decays of a neutral Higgs boson into a pair of gluon or photon have great implications for the Higgs discovery at the LHC. If the Higgs boson is heavy with mass above $\\sim 500\\gev$, however, these radiative branching ratios are very suppressed in the standard model, as the new decay channels are kinematically open. We note that these radiative decays can be sizable for the heavy second Kaluza-Klein (KK) CP-even $h^\\tw$ and CP-odd $\\chi^\\tw$ modes of the Higgs boson in the minimal universal extra dimension (mUED) model with the KK parity conservation: highly degenerate mass spectrum of the theory prohibits kinematically the dominant KK-number conserving decays into the first KK modes of the $W$, $Z$ and top quark. We find that $h^{(2)} \\to g g$ is absent at one loop level since $h^{(2)}$ couples with different mass eigenstates of $t_{1,2}^\\on$ while the gluon with the same mass eigenstates. The $h^\\tw$ production at the LHC is very suppressed. On the contrary, we have ${\\rm BR} (\\chi^\\tw \\to g g)...

  6. Constraints on universal extra dimension models with gravity mediated decays from ATLAS diphoton search

    Science.gov (United States)

    Ghosh, Kirtiman; Huitu, Katri

    2012-06-01

    We discuss the collider phenomenology of Universal Extra Dimension models with gravity mediated decays. We concentrate on diphoton associated with large missing transverse energy signature. At the collider, level-1 Kaluza-Klein (KK) particles are produced in pairs due to the conservation of KK-parity. Subsequently, KK-particles decay via cascades involving lighter KK-particles until reaching the lightest KK-particle (LKP). Finally, gravity induced decay of the LKP into photons gives rise to the diphoton signature. The search for diphoton events with large missing transverse energy was recently communicated by the ATLAS collaboration for 7 TeV center-of-mass energy and 3.1 inverse femtobarn integrated luminosity of the Large Hadron Collider. Above the Standard Model background prediction, no excess of such events was reported. We translate the absence of any excess of the diphoton events to constrain the model parameters, namely, the radius of compactification ( R) and the fundamental Planck mass ( M D ).

  7. Constraints on Universal Extra Dimension models with gravity mediated decays from ATLAS diphoton search

    CERN Document Server

    Ghosh, Kirtiman

    2012-01-01

    We discuss the collider phenomenology of Universal Extra Dimension models with gravity mediated decays. We concentrate on diphoton associated with large missing transverse energy signature. At the collider, level-1 Kaluza-Klein (KK) particles are produced in pairs due to the conservation of KK-parity. Subsequently, KK-particles decay via cascades involving lighter KK-particles until reaching the lightest KK-particle (LKP). Finally, gravity induced decay of the LKP into photons gives rise to the diphoton signature. The search for diphoton events with large missing transverse energy was recently communicated by the ATLAS collaboration for 7 TeV center-of-mass energy and 3.1 inverse femtobarn integrated luminosity of the Large Hadron Collider. Above the Standard Model background prediction, no excess of such events was reported. We translate the absence of any excess of the diphoton events to constrain the model parameters, namely, the radius of compactification (R) and the fundamental Planck mass ($M_D$).

  8. Intra- and extra-familial adverse childhood experiences and a history of childhood psychosomatic disorders among Japanese university students

    Directory of Open Access Journals (Sweden)

    Munemoto Takao

    2007-04-01

    Full Text Available Abstract Background Japan has been witnessing a considerable increase in the number of children with psychosomatic disorders. The purpose of this study is to examine the relationship between the risk of psychosomatic disorder in adolescents and intra- and extra-familial adverse childhood experiences (ACEs. Methods A retrospective cohort study of 1592 Japanese university students (52% male, mean age 19.9 years who completed a survey about intra- and extra-familial ACEs and the incidence of childhood psychosomatic disorders. Intra-familial ACEs included domestic violence, physical violence, emotional abuse, illness in household, parental divorce, no parental affection, and dysfunctional family. Extra-familial ACEs included physical violence or negative recognition by teachers, being bullied in elementary or junior high school, or sexual violence. Results The frequency of psychosomatic disorders among the respondents was 14.8%. Among the 7 intra-familial ACEs, emotional abuse (relative risk, RR = 1.9 and illness in household (RR = 1.7 increased the risk of psychosomatic disorders. Estimates of the relative risk for the 5 extra-familial ACEs were statistically significant and ranged from 1.5 for being bullied in elementary school or physical violence from teachers to 2.4. Students who had 3 or more intra-familial ACEs and 2 or more extra-familial ACEs had a 3.0 relative risk for psychosomatic disorder. Conclusion These results suggest that intra- and extra-familial ACEs are associated with the development of psychosomatic disorders. Therefore, sufficient evaluation of ACEs should be performed in adolescent patients with psychosomatic disorder.

  9. Intra- and extra-familial adverse childhood experiences and a history of childhood psychosomatic disorders among Japanese university students

    Science.gov (United States)

    Masuda, Akinori; Yamanaka, Takao; Hirakawa, Tadatoshi; Koga, Yasuyuki; Minomo, Ryosuke; Munemoto, Takao; Tei, Chuwa

    2007-01-01

    Background Japan has been witnessing a considerable increase in the number of children with psychosomatic disorders. The purpose of this study is to examine the relationship between the risk of psychosomatic disorder in adolescents and intra- and extra-familial adverse childhood experiences (ACEs). Methods A retrospective cohort study of 1592 Japanese university students (52% male, mean age 19.9 years) who completed a survey about intra- and extra-familial ACEs and the incidence of childhood psychosomatic disorders. Intra-familial ACEs included domestic violence, physical violence, emotional abuse, illness in household, parental divorce, no parental affection, and dysfunctional family. Extra-familial ACEs included physical violence or negative recognition by teachers, being bullied in elementary or junior high school, or sexual violence. Results The frequency of psychosomatic disorders among the respondents was 14.8%. Among the 7 intra-familial ACEs, emotional abuse (relative risk, RR = 1.9) and illness in household (RR = 1.7) increased the risk of psychosomatic disorders. Estimates of the relative risk for the 5 extra-familial ACEs were statistically significant and ranged from 1.5 for being bullied in elementary school or physical violence from teachers to 2.4. Students who had 3 or more intra-familial ACEs and 2 or more extra-familial ACEs had a 3.0 relative risk for psychosomatic disorder. Conclusion These results suggest that intra- and extra-familial ACEs are associated with the development of psychosomatic disorders. Therefore, sufficient evaluation of ACEs should be performed in adolescent patients with psychosomatic disorder. PMID:17407551

  10. Deciphering Journal Abbreviations with JAbbr

    OpenAIRE

    Keith Jenkins

    2009-01-01

    JAbbr is an online tool developed at Cornell University to help users decipher journal title abbreviations. This article discusses why these abbreviations are so problematic, and how traditional tools are often insufficient, and then describes the novel approach used by JAbbr. Given an abbreviation, JAbbr creates a regular expression for fuzzy matching, tests it against a list of serial titles extracted from the library catalog, and returns a list of possible matches to the user. JAbbr is ava...

  11. Extra-curricular methods for improving the quality of the staff training in the university of civil engineering (psychological content

    Directory of Open Access Journals (Sweden)

    Magera Tatiana

    2017-01-01

    Full Text Available High technologies in architecture and construction change the world around. Professional trainings for the creators of the artificial environment (engineers and architects have an effect on people’s life but practically they don’t take into account the human nature of the final user and his own psychological features. In this article there are presented the results of the psychological services in the University of civil engineering from 2006 to 2017 as extra-curricular methods for the general competences formation and development. There are also described the methods of works and their specifics, some difficulties and perspectives. There are explained the reasons for psychological service at the university of civil engineering. There are also taken into account the global risks and dangers affecting the study content of civil engineering.

  12. Deciphering Journal Abbreviations with JAbbr

    Directory of Open Access Journals (Sweden)

    Keith Jenkins

    2009-06-01

    Full Text Available JAbbr is an online tool developed at Cornell University to help users decipher journal title abbreviations. This article discusses why these abbreviations are so problematic, and how traditional tools are often insufficient, and then describes the novel approach used by JAbbr. Given an abbreviation, JAbbr creates a regular expression for fuzzy matching, tests it against a list of serial titles extracted from the library catalog, and returns a list of possible matches to the user. JAbbr is available as a web site and as a web service.

  13. Transition of Treatment for Patients with Extra-Abdominal Desmoid Tumors: Nagoya University Modality

    Energy Technology Data Exchange (ETDEWEB)

    Nishida, Yoshihiro, E-mail: ynishida@med.nagoya-u.ac.jp; Tsukushi, Satoshi [Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65-Tsurumai, Showa, Nagoya 466-8550 (Japan); Shido, Yoji [Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192 (Japan); Urakawa, Hiroshi; Arai, Eisuke; Ishiguro, Naoki [Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65-Tsurumai, Showa, Nagoya 466-8550 (Japan)

    2012-02-07

    Treatment modalities for desmoid tumors have been changed because of the high recurrence rate, even after wide resection, and some cases experience spontaneous self-regression during clinical course. The treatment modality in our institutions before 2003 was surgical resection with wide surgical margin, however, meloxicam, which is a NSAID and a selective COX-2 inhibitor has been applied consecutively since 2003. We reviewed the previously reported outcomes of surgical and conservative treatment in our institutions. Among 30 patients receiving surgical treatment, 16 (53%) recurred. Younger age (p < 0.05) was a significant poor factor. According to RECIST for meloxicam treatment, CR was in one, PR in 10, SD in eight, PD in one evaluated at 2011. Older age (p < 0.01) was significantly associated with good outcome for meloxicam treatment. Results of the previous study indicated that surgical treatment alone could not control desmoid tumors, even with negative surgical margin. Considering the functional impairment resulting from surgery with negative surgical margin, a conservative and effective treatment modality with fewer complications is desired. Conservative treatment with meloxicam is a promising novel modality for patients with extra-abdominal desmoid tumors.

  14. Transition of Treatment for Patients with Extra-Abdominal Desmoid Tumors: Nagoya University Modality

    Directory of Open Access Journals (Sweden)

    Naoki Ishiguro

    2012-02-01

    Full Text Available Treatment modalities for desmoid tumors have been changed because of the high recurrence rate, even after wide resection, and some cases experience spontaneous self-regression during clinical course. The treatment modality in our institutions before 2003 was surgical resection with wide surgical margin, however, meloxicam, which is a NSAID and a selective COX-2 inhibitor has been applied consecutively since 2003. We reviewed the previously reported outcomes of surgical and conservative treatment in our institutions. Among 30 patients receiving surgical treatment, 16 (53% recurred. Younger age ( p < 0.05 was a significant poor factor. According to RECIST for meloxicam treatment, CR was in one, PR in 10, SD in eight, PD in one evaluated at 2011. Older age ( p < 0.01 was significantly associated with good outcome for meloxicam treatment. Results of the previous study indicated that surgical treatment alone could not control desmoid tumors, even with negative surgical margin. Considering the functional impairment resulting from surgery with negative surgical margin, a conservative and effective treatment modality with fewer complications is desired. Conservative treatment with meloxicam is a promising novel modality for patients with extra-abdominal desmoid tumors.

  15. The Representation of Library Value in Extra-Institutional Evaluations of University Quality

    Science.gov (United States)

    Jackson, Brian

    2017-01-01

    The ways in which university quality assessments are developed reveal a great deal about value constructs surrounding higher education. Measures developed and consumed by external stakeholders, in particular, indicate which elements of academia are broadly perceived to be most reflective of quality. This paper examines the historical context of…

  16. Gravitino in the early Universe. A model of extra-dimension and a model of dark matter; Gravitino dans l'Univers primordial: un modele d'extra-dimension et de matiere noire

    Energy Technology Data Exchange (ETDEWEB)

    Gherson, D

    2007-10-15

    This work can be related to the Horava-Witten M-theory in which the Universe could appear 5 dimensional at a stage of its evolution but also to theories of Baryogenesis through Lepto-genesis which imply high reheating temperatures after Inflation. The studied cosmological model is within the framework of a 5 dimensional supergravity with the extra-dimension compactified on an orbifold circle, where the matter and gauge field are located on one of the two branes localised at the orbifold fixed points and where the supergravity fields can propagate in the whole spatial dimensions. In the model, the Dark matter is made of neutralino which is supposed to be the lightest supersymmetric particle. We have shown that there are curves of constraints between the size of the extra-dimension and the reheating temperature of the Universe after Inflation. The constraints come from the measurements of the amount of Dark matter in the Universe and from the model of the Big Bang Nucleosynthesis of light elements. (author)

  17. A Search for universal extra dimensions in the multi-lepton channel from proton anti-proton collisions at √s = 1.8 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Chun [Yale Univ., New Haven, CT (United States)

    2005-12-01

    In this thesis we present the results of a search for Universal Extra Dimensions (UED) with compactification radius near the TeV scale in the multi-lepton channel from proton-antiproton collisions at center-of-mass energy of 1.8 TeV at the Fermi National Accelerator Laboratory. This is the first UED search in the multi-lepton channel performed at the Tevatron.

  18. SCONUL Research Extra

    OpenAIRE

    John Hall

    2006-01-01

    SCONUL Research Extra is a cooperative access and borrowing scheme for staff and research students in UK and Irish higher education institutions. Under the terms of the scheme, eligible researchers may visit any participating library and register as an external borrower. The scheme is run on behalf of SCONUL, the Society of College, National and University Libraries which represents the directors of the library and information services in all the universities of the United Kingdom and Ireland...

  19. University Adult Education in Independent Zambia: The Role of a Department of Extra-Mural Studies in National Development

    Science.gov (United States)

    Okafor, Clement Abiazem

    1971-01-01

    Like other African countries, Zambia's most pragmatic approach to national development must lie in adult education. The University of Zambia is one agency involved toward this goal and its emphasis is on rapid expansion of university-type education and the training of adult educators. (Author/JB)

  20. Decipher

    CERN Multimedia

    2002-01-01

    Review of a new fiction work by Stel Pavlou whose starting point is the lifecycle of the sun and the implications for human civilization. The story invokes the use of the CERN accelerator to analyze a special type of crystal found in Antartica which may hold the key to the legend of the city of Atlantis (1/2 page).

  1. SCONUL Research Extra

    Directory of Open Access Journals (Sweden)

    John Hall

    2006-04-01

    Full Text Available SCONUL Research Extra is a cooperative access and borrowing scheme for staff and research students in UK and Irish higher education institutions. Under the terms of the scheme, eligible researchers may visit any participating library and register as an external borrower. The scheme is run on behalf of SCONUL, the Society of College, National and University Libraries which represents the directors of the library and information services in all the universities of the United Kingdom and Ireland, and in most other UK institutions of higher education, and the directors of the national libraries; it is for all institutions in membership of SCONUL able to lend library materials and, with 158 institutions signed up, it is now the largest reciprocal borrowing scheme in the UK and Ireland, serving almost the entire membership of SCONUL.

  2. Cosmology with dynamical extra dimensions

    Science.gov (United States)

    Erickson, Joel K.

    Nearly every attempt to unify the fundamental forces incorporates the idea of compact extra dimensions. The notion was introduced by Kaluza and Klein in the 1920s and is an essential part of contemporary string theory and M-theory. In most treatments the extra dimensions are static. We consider the consequences of extra dimensions with time-varying radii. The radii are modeled by light scalar fields. These may have unusual properties which produce observable effects, such as non-canonical kinetic energies, couplings to matter and radiation, and non-minimal coupling to gravity. Extra dimensions may be responsible for dark energy in the late universe. The simplest model of dark energy is characterized by its equation of state. We show that constraints placed on realistic models by the universality of free fall, variation of fundamental constants and metric tests of gravity are often stricter than bounds on the equation of state. Testing the equivalence principle maybe an effective way of distinguishing some quintessence models from a cosmological constant. In certain dark energy models the speed of sound is much less than the speed of light. We calculate how this affects the cosmic microwave background and show that the speed of sound may be measurable, provided dark energy is sufficiently dense at decoupling. This is another possible signature of quintessence. Dynamical extra dimensions may have consequences for the early universe. In the cyclic model, the universe is described in terms of a series of contractions and expansions of an extra dimension. The big bang is preceded by a big crunch and quantum fluctuations of the scalar field produce structure in universe. We consider how the fluctuations evolve and build over many cycles and show that there are no observable instabilities or adverse effects. In the cyclic model extra dimensions act as both dark energy and as an agent to cause contraction and a big crunch. Previous theorems suggested that contraction

  3. Cosmology With Dynamical Extra Dimensions

    CERN Document Server

    Erickson, J K

    2005-01-01

    Nearly every attempt to unify the fundamental forces incorporates the idea of compact extra dimensions. The notion was introduced by Kaluza and Klein in the 1920s and is an essential part of contemporary string theory and M-theory. In most treatments the extra dimensions are static. We consider the consequences of extra dimensions with time-varying radii. The radii are modeled by light scalar fields. These may have unusual properties which produce observable effects, such as non-canonical kinetic energies, couplings to matter and radiation, and non- minimal coupling to gravity. Extra dimensions may be responsible for dark energy in the late universe. The simplest model of dark energy is characterized by its equation of state. We show that constraints placed on realistic models by the universality of free fall, variation of fundamental constants and metric tests of gravity are often stricter than bounds on the equation of state. Testing the equivalence principle maybe an effective way of distinguishing some qu...

  4. Wormholes leading to extra dimensions

    CERN Document Server

    Bronnikov, K A

    2016-01-01

    In 6D general relativity with a scalar field as a source of gravity, a new type of static wormhole solutions is presented: such wormholes connect our universe with a small 2D extra subspace with a universe where this extra subspace is large, and the whole space-time is effectively 6-dimensional. We consider manifolds with the structure M0 x M1 x M2 , where M0 is 2D Lorentzian space-time while each of M1 an M2 can be a 2-sphere or a 2-torus. After selecting possible asymptotic behaviors of the metric functions compatible with the field equations, we give two explicit examples of wormhole solutions with spherical symmetry in our space-time and toroidal extra dimensions. In one example, with a massless scalar field (it is a special case of a well-known more general solution), the extra dimensions have a large constant size at the "far end"; the other example contains a nonzero potential $V(\\phi)$ which provides a 6D anti-de Sitter asymptotic, where all spatial dimensions are infinite.

  5. Acid fast bacillus pulmonary and extra pulmonary in a laboratory of university hospital center in Antananarivo, Madagascar since 2003-2014

    Directory of Open Access Journals (Sweden)

    Andry M. Andrianarivelo

    2015-12-01

    Results: During 12 years, 1060 requests have been received to research AFB with 89 cases (8.39% of positivity. Patients were between 9 months and 93 years old. The middle patient age was 41.7 years. Sex-ratio of infected patients was 1.36. There was a significant difference between gender and positive cases (p=0,001. 82 positive cases (93.77% were pulmonary localization and 7 cases of extra pulmonary (6.23%. Conclusions: Despite the lack of screening, the high rate of bacillary pulmonary tuberculosis found was one of the great epidemiological importances because of their contagiousness. It is obvious that only health actions cannot solve the problem of tuberculosis. [Int J Res Med Sci 2015; 3(12.000: 3576-3580

  6. Introduction to Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Rizzo, Thomas G.; /SLAC

    2010-04-29

    Extra dimensions provide a very useful tool in addressing a number of the fundamental problems faced by the Standard Model. The following provides a very basic introduction to this very broad subject area as given at the VIII School of the Gravitational and Mathematical Physics Division of the Mexican Physical Society in December 2009. Some prospects for extra dimensional searches at the 7 TeV LHC with {approx}1 fb{sup -1} of integrated luminosity are provided.

  7. Editorial: Focus on Extra Space Dimensions

    Science.gov (United States)

    Agashe, Kaustubh; Pomarol, Alex

    2010-07-01

    Experiments at the Large Hadron Collider (LHC) have just started. In addition to verifying the Standard Model (SM) of particle physics, these experiments will probe a new energy frontier and test extensions of the SM. The existence of extra dimensions is one of the most attractive possibilities for physics beyond the SM. This focus issue contains a collection of articles addressing both theoretical and phenomenological aspects of extra-dimensional models. Focus on Extra Space Dimensions Contents Minimal universal extra dimensions in CalcHEP/CompHEP AseshKrishna Datta, Kyoungchul Kong and Konstantin T Matchev Disordered extra dimensions Karim Benakli Codimension-2 brane-bulk matching: examples from six and ten dimensions Allan Bayntun, C P Burgess and Leo van Nierop Gauge threshold corrections in warped geometry Kiwoon Choi, Ian-Woo Kim and Chang Sub Shin Holographic methods and gauge-Higgs unification in flat extra dimensions Marco Serone Soft-wall stabilization Joan A Cabrer, Gero von Gersdorff and Mariano Quirós Warped five-dimensional models: phenomenological status and experimental prospects Hooman Davoudiasl, Shrihari Gopalakrishna, Eduardo Pontón and José Santiago

  8. Flavor Symmetries in Extra Dimensions

    CERN Document Server

    Aranda, A; Aranda, Alfredo

    2002-01-01

    We present a model of flavor based on a discrete local symmetry that reproduces all fermion masses and mixing angles both in the quark and lepton sectors. The particle content of the model is that of the standard model plus an additional flavon field. All the fields propagate in a fifth universal extra dimension and the flavor scale is associated with the cutoff of the 5D theory which is $\\sim 10$ TeV. The Yukawa matrices as well as the Majorana mass matrix for the neutrinos are generated by higher dimension operators involving the flavon field. When the flavon field acquires a vacuum expectation value it breaks the flavor symmetry and thus generates the Yukawa couplings. The model is consistent with the nearly bimaximal solution to the solar and atmospheric neutrino deficits.

  9. Cosmology With Extra Dimensions

    CERN Document Server

    Martín, J

    2005-01-01

    We review several properties of models that include extra dimensions, focusing on aspects related to cosmology and particle physics phenomenology. The properties of effective four dimensional inflationary geometry are studied in two distinct frameworks: (i) in Kaluza- Klein (KK) compactifications and (ii) in braneworld scenarios. From numerical simulations we find that inflationary braneworlds are unstable if the scale of inflation is too large in comparison with the stabilization scale of the interbrane distance. The analysis of perturbations confirms the existence of a tachyon associated with the volume modulus of the extra dimensions both in braneworlds and KK compactifications. With the numerical program BRANECODE non- perturbative properties of braneworlds are studied. We fully understand the non-perturbative consequences of this instability. Generic attractors are (i) an increase of the interbrane distance and the formation of a naked singularity, (ii) the brane colli...

  10. Phenomenology of Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Hewett, J.L.; /SLAC

    2006-11-07

    If the structure of spacetime is different than that readily observed, gravitational physics, particle physics and cosmology are all immediately affected. The physics of extra dimensions offers new insights and solutions to fundamental questions arising in these fields. Novel ideas and frameworks are continuously born and evolved. They make use of string theoretical features and tools and they may reveal if and how the 11-dimensional string theory is relevant to our four-dimensional world. We have outlined some of the experimental observations in particle and gravitational physics as well as astrophysical and cosmological considerations that can constrain or confirm these scenarios. These developing ideas and the wide interdisciplinary experimental program that is charted out to investigate them mark a renewed effort to describe the dynamics behind spacetime. We look forward to the discovery of a higher dimensional spacetime.

  11. Qubits from extra dimensions

    CERN Document Server

    Lévay, Péter

    2011-01-01

    We link the recently discovered black hole-qubit correspondence to the structure of extra dimensions. In particular we show that for toroidal compactifications of type IIB string theory simple qubit systems arise naturally from the geometrical data of the tori parametrized by the moduli. We also generalize the recently suggested idea of the attractor mechanism as a distillation procedure of GHZ-like entangled states on the event horizon, to moduli stabilization for flux attractors in F-theory compactifications on elliptically fibered Calabi-Yau four-folds. Finally using a simple example we show that the natural arena for qubits to show up is an embedded one within the realm of fermionic entanglement of quantum systems with indistinguishable constituents.

  12. Deciphering interactions in moving animal groups.

    Directory of Open Access Journals (Sweden)

    Jacques Gautrais

    Full Text Available Collective motion phenomena in large groups of social organisms have long fascinated the observer, especially in cases, such as bird flocks or fish schools, where large-scale highly coordinated actions emerge in the absence of obvious leaders. However, the mechanisms involved in this self-organized behavior are still poorly understood, because the individual-level interactions underlying them remain elusive. Here, we demonstrate the power of a bottom-up methodology to build models for animal group motion from data gathered at the individual scale. Using video tracks of fish shoal in a tank, we show how a careful, incremental analysis at the local scale allows for the determination of the stimulus/response function governing an individual's moving decisions. We find in particular that both positional and orientational effects are present, act upon the fish turning speed, and depend on the swimming speed, yielding a novel schooling model whose parameters are all estimated from data. Our approach also leads to identify a density-dependent effect that results in a behavioral change for the largest groups considered. This suggests that, in confined environment, the behavioral state of fish and their reaction patterns change with group size. We debate the applicability, beyond the particular case studied here, of this novel framework for deciphering interactions in moving animal groups.

  13. Using Extra Credit to Facilitate Extra Learning in Students

    Directory of Open Access Journals (Sweden)

    Mohammad Muztaba Fuad

    2012-06-01

    Full Text Available Giving students extra credit work is a hotly debated pedagogical issue. This paper shares experience of using extra credit quizzes to push students to think critically and beyond the boundaries. This particular type of quizzes are not announced before and presented to students as a surprise quiz. A certain percentage of the grade earned in these quizzes was included in student’s final grade calculations. With a well-developed model of questions, quiz structure and grade calculation, the presented model of extra credit eliminates negativity related to extra credit work and also motivates students into course work. Our findings showed that by relieving students from the mental pressure of test taking and by making those tests/quizzes as extra credit; students actually performs better in solving harder problems and eventually learns more of the advanced course topics.

  14. Extra Low ENergy Antiproton

    CERN Multimedia

    To produce dense antiproton beams at very low energies (110 keV), it has been proposed to install a small decelerator ring between the existing AD ring and the experimental area. Phase-space blowup during deceleration is compensated by electron cooling such that the final emittances are comparable to the 5MeV beam presently delivered by the AD. An immediate consequence is a significant increase in the number of trapped antiprotons at the experiments as outlined in the proposal CERN/SPSC-2009-026; SPCS-P-338. This report describes the machine parameters and layout of the proposal ELENA (Extra Low ENergy Antiproton)ring also gives an approximate estimate of cost and manpower needs. Since the initial estimate, published in 2007 (CERN-AB-2007-079), the ELENA design has evolved considerably. This is due to a new location in the AD hall to acommodate for the possibility of another experimental zone, as suggested by the SPCS, and also due to improvements in the ring optics and layout. The cost estimate that is prese...

  15. Casimir effect for a Cavity in the Spacetime with an Extra Dimension

    Institute of Scientific and Technical Information of China (English)

    CHENG Hong-Bo

    2005-01-01

    @@ We reexamine the Casimir effect for the rectangular cavity with two or three equal edges in the presence of compactified universal extra dimension. We derive the expressions for the Casimir energy and discuss the nature of Casimir force. We show analytically the extra-dimension corrections to the standard Casimir effect to put forward a new method of exploring the existence of extra dimensions of the Universe.

  16. Supersymmetry breaking with extra dimensions

    Indian Academy of Sciences (India)

    Fabio Zwirner

    2004-02-01

    This talk reviews some aspects of supersymmetry breaking in the presence of extra dimensions. The first part is a general introduction, recalling the motivations for supersymmetry and extra dimensions, as well as some unsolved problems of four-dimensional models of supersymmetry breaking. The central part is a more focused introduction to a mechanism for (super)symmetry breaking, proposed first by Scherk and Schwarz, where extra dimensions play a crucial role. The last part is devoted to the description of some recent results and of some open problems.

  17. The Universe’s extra bits

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Parallel universes, unknown forms of matter, extra dimensions….This is not cheap science fiction but very concrete physics theories that the scientists are trying to confirm with the LHC and other ongoing experiments. Although it's enough to make us dream about going to a parallel world for the weekend, let’s keep our feet firmly on the ground and try to work out what all these things really are…   Given the astonishing fact that 96% of the Universe is actually unknown, we can think of filling it with all sorts of weird and exotic things. Extra dimensions and parallel universes may indeed be real, that is, their existence is accepted by a large community of scientists who have worked out mathematical models and physical constraints. “The idea of a fifth dimension was first introduced by Kaluza and Klein at the beginning of the last century in an attempt to unify gravity and electromagnetism”, confirms Ignatios Antoniadis from CERN’s Th...

  18. Inflation from periodic extra dimensions

    CERN Document Server

    Higaki, Tetsutaro

    2016-01-01

    We discuss a realization of a small field inflation based on string inspired supergravities. In theories accompanying extra dimensions, compactification of them with small radii is required for realistic situations. Since the extra dimension can have a periodicity, there will appear (quasi-)periodic functions under transformations of moduli of the extra dimensions in low energy scales. Such a periodic property can lead to a UV completion of so-called multi-natural inflation model where inflaton potential consists of a sum of multiple sinusoidal functions with a decay constant smaller than the Planck scale. As an illustration, we construct a SUSY breaking model, and then show that such an inflaton potential can be generated by a sum of world sheet instantons in intersecting brane models on extra dimensions containing $T^2/{\\mathbb Z}_2$ orbifold. We show also predictions of cosmic observables by numerical analyzes.

  19. Enhanced gravitational scattering from large extra dimensions

    CERN Document Server

    Koyama, K; Wands, D; Koyama, Kazuya; Piazza, Federico; Wands, David

    2005-01-01

    We show that enhanced gravitational scattering on small scales (< 0.1 mm), which becomes possible in models with large extra dimensions, can establish statistical equilibrium between different particle species in the early Universe. Ultra-light WIMPs (e.g., axions) can be thermalized by such a mechanism and therefore are not viable CDM candidates in models with a fundamental Planck scale below about 10 TeV. More generally we note that the energy transfer rate is sensitive to trans-Planckian physics

  20. Neutrino and Extra World

    CERN Document Server

    Baranov, D S

    2012-01-01

    The neutrino speed measurement experiments are the continuations of the classic light speed measurement experiments have been done in range of the solar planet system (Ole Roemer, 1676), in star system (James Braidely, 1728) and, at last, on the Earth (Lois Fizeau, 1849),.... The finite light speed measurement has led to the revolution in the humanity consciousness and eventually led to a new understanding of the visible universe. In 1998-2005, we had a lot of excited discussions at CERN about the possibilities to perform the neutrino experiments to test the superluminal neutrino hypothesis and to find new phenomena beyond the SM. From one hand the idea of such experiments was associated with the hope to understand the role of the V-A- weak interactions, the quark-lepton family symmetry, the neutrino space-time properties and to observe some indications on a new vacuum structure existence outside of the Weak Scale, i.e. in the region 1/R ~ (0.1-20) TeV. From another hand the general trends of this idea has be...

  1. Extra Stimulation in Intermediate Grade Reading.

    Science.gov (United States)

    Mason, George E.

    Three types of extra stimulation in reading are discussed: extra teacher time devoted to teaching reading, extra student time devoted to practice in reading, and extra motivation and reinforcement leading to greater amounts of student reading outside the school. Problems are created (1) when teaching time spent on reading is increased in the…

  2. Collider searches for extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Landsberg, Greg; /Brown U.

    2004-12-01

    Searches for extra spatial dimensions remain among the most popular new directions in our quest for physics beyond the Standard Model. High-energy collider experiments of the current decade should be able to find an ultimate answer to the question of their existence in a variety of models. Until the start of the LHC in a few years, the Tevatron will remain the key player in this quest. In this paper, we review the most recent results from the Tevatron on searches for large, TeV{sup -1}-size, and Randall-Sundrum extra spatial dimensions, which have reached a new level of sensitivity and currently probe the parameter space beyond the existing constraints. While no evidence for the existence of extra dimensions has been found so far, an exciting discovery might be just steps away.

  3. Flavor Models In Extra Dimensions

    CERN Document Server

    Valadez, J

    2005-01-01

    This thesis consists of implementing flavor symmetries in the context of extra dimensions. To the particle content of the Standard Model we add an additional scalar (flavon) field and we assume that all the fields propagate in the extra-dimensional space-time. When the flavon field acquires a vacuum expectation value the flavor symmetry is effectively broken thus generating the Yukawa textures associated with the particles. An specific model in 5D that reproduces all fermion masses, mixing angles and ratios is presented.

  4. Signatures of Large Extra Dimensions

    CERN Document Server

    Hossenfelder, S; Stöcker, H

    2004-01-01

    String theory suggests modifications of our spacetime such as extra dimensions and the existence of a mininal length scale. In models with addidional dimensions, the Planck scale can be lowered to values accessible by future colliders. Effective theories which extend beyond the standart-model by including extra dimensions and a minimal length allow computation of observables and can be used to make testable predictions. Expected effects that arise within these models are the production of gravitons and black holes. Furthermore, the Planck-length is a lower bound to the possible resolution of spacetime which might be reached soon.

  5. Reading Hidden Messages Through Deciphered Manual Alphabets on Classic Artwork

    Science.gov (United States)

    Castronovo, Joseph Anthony, Jr.

    1998-10-01

    Decipherment is the tool used to uncover several types of hand signs that played vital roles in the creation of hidden messages in classic artwork. A 3,100 B.C. bas-relief of The 'Kaph' Telescope, formerly named The Narmer Palette, and Michaelangelo Buonarrotte's Battle of Cascina of 1506 were two key works of art that show certain similarities even though separated by 4,500 years. It is evident that Renaissance humanists provided artists with certain knowledge of the ancients. Results of incorporating a number of minor works of art showed that the competence of ancient Egyptians, Cretans and Australian Aboriginals, to name a few, as astronomers, was underestimated. Some deciphered Indus seals attested to a global understanding of the universe, with Gemini and the star of Thuban at the center of their attention. Certain forms of secrecy had to be undertaken for various reasons throughout the millennia. Three examples are: (1) In Italy, to keep controversial and truthful teachings discreet and hidden, artists embedded them in artwork long before the plight of Galileo Galilei and his discoveries. (2) Among Jewish Kabbalists, a well-known design was obscured in The Arnolfini Wedding painting for fear it would be lost due to persecution. (3) Michaelangelo Buonarrotte indicated several meanings through the hands of The Statue of Moses. They were overlooked by several societies, including the gesticulating culture of Italy, because they oppressed the value of signed languages. Spatial decipherment may testify to a need for the restoration of a spatial writing system for expanded linguistic accessibility. A 21st century model community for sign language residents and employees will benefit visual learners, particularly visual artists and non-phonetic decipherers, to better uncover, understand and perhaps use ancient hand forms to restore ancient knowledge. Moreover, the National Association of Teaching English (NATE) has recently endorsed the addition of two skills

  6. Origin of the 'Extra Entropy'

    Science.gov (United States)

    Mushotzky, R.

    2008-01-01

    I will discuss how one can determine the origin of the 'extra entropy' in groups and clusters and the feedback needed in models of galaxy formation. I will stress the use of x-ray spectroscopy and imaging and the critical value that Con-X has in this regard.

  7. Phenomenology of S_4 Flavor Symmetric extra U(1) model

    CERN Document Server

    Daikoku, Yasuhiro

    2013-01-01

    We study several phenomenologies of an E_6 inspired extra U(1) model with S_4 flavor symmetry. With the assignment of left-handed quarks and leptons to S_4-doublet, SUSY flavor problem is softened. As the extra Higgs bosons are neutrinophilic, baryon number asymmetry in the universe is realized by leptogenesis without causing gravitino overproduction. We find that the allowed region for the lightest chargino mass is given by 100-140 GeV, if the dark matter is a singlino dominated neutralino whose mass is about 36 GeV.

  8. Dynamical Electroweak Symmetry Breaking from Extra Dimensions

    CERN Document Server

    Hashimoto, M; Yamawaki, K; Hashimoto, Michio; Tanabashi, Masaharu; Yamawaki, Koichi

    2003-01-01

    We study the dynamical electroweak symmetry breaking (DEWSB) in the $D (=6,8,...)$-dimensional bulk with compactified extra dimensions. We identify the critical binding strength for triggering the DEWSB, based on the ladder Schwinger-Dyson equation. In the top mode standard model with extra dimensions, where the standard model gauge bosons and the third generation of quarks and leptons are put in the bulk, we analyze the most attractive channel (MAC) by using renormalization group equations (RGEs) of (dimensionless) bulk gauge couplings and determine the effective cutoff where the MAC coupling exceeds the critical value. We then find that the top-condensation can take place for D=8. Combining RGEs of top-Yukawa and Higgs-quartic couplings with compositeness conditions, we predict the top mass, $m_t=173-180$ GeV, and the Higgs mass, $m_H=181-211$ GeV, for D=8, where we took the universal compactification scale $1/R = 1-100$ TeV.

  9. Dynamical Electroweak Symmetry Breaking from Extra Dimensions

    Science.gov (United States)

    Hashimoto, Michio; Tanabashi, Masaharu; Yamawaki, Koichi

    2003-08-01

    We study the dynamical electroweak symmetry breaking (DEWSB) in the D(= 6, 8, ⋯)-dimensional bulk with compactified extra dimensions. We identify the critical binding strength for triggering the DEWSB, based on the ladder Schwinger-Dyson equation. In the top mode standard model with extra dimensions, where the standard model gauge bosons and the third generation of quarks and leptons are put in the bulk, we analyze the most attractive channel (MAC) by using renormalization group equations (RGEs) of (dimensionless) bulk gauge couplings and determine the effective cutoff where the MAC coupling exceeds the critical value. We then find that the top-condensation can take place for D = 8. Combining RGEs of top-Yukawa and Higgs-quartic couplings with compositeness conditions, we predict the top mass, mt = 173 - 180 GeV, and the Higgs mass, mH = 181 - 211 GeV, for D = 8, where we took the universal compactification scale 1/R = 1 - 100 TeV.

  10. Deciphering spectral fingerprints of habitable exoplanets.

    Science.gov (United States)

    Kaltenegger, Lisa; Selsis, Frank; Fridlund, Malcolm; Lammer, Helmut; Beichman, Charles; Danchi, William; Eiroa, Carlos; Henning, Thomas; Herbst, Tom; Léger, Alain; Liseau, René; Lunine, Jonathan; Paresce, Francesco; Penny, Alan; Quirrenbach, Andreas; Röttgering, Huub; Schneider, Jean; Stam, Daphne; Tinetti, Giovanna; White, Glenn J

    2010-01-01

    We discuss how to read a planet's spectrum to assess its habitability and search for the signatures of a biosphere. After a decade rich in giant exoplanet detections, observation techniques have advanced to a level where we now have the capability to find planets of less than 10 Earth masses (M(Earth)) (so-called "super Earths"), which may be habitable. How can we characterize those planets and assess whether they are habitable? This new field of exoplanet search has shown an extraordinary capacity to combine research in astrophysics, chemistry, biology, and geophysics into a new and exciting interdisciplinary approach to understanding our place in the Universe. The results of a first-generation mission will most likely generate an amazing scope of diverse planets that will set planet formation, evolution, and our planet into an overall context.

  11. Deciphering Spectral Fingerprints of Habitable Extrasolar Planets

    CERN Document Server

    Kaltenegger, L; Fridlund, M; Lammer, H; Beichman, Ch; Danchi, W; Eiroa, C; Henning, T; Herbst, T; Léger, A; Liseau, R; Lunine, J; Paresce, F; Penny, A; Quirrenbach, A; Roettgering, H; Schneider, J; Stam, D; Tinetti, G; White, G J

    2009-01-01

    In this paper we discuss how we can read a planets spectrum to assess its habitability and search for the signatures of a biosphere. After a decade rich in giant exoplanet detections, observation techniques have now reached the ability to find planets of less than 10 MEarth (so called Super-Earths) that may potentially be habitable. How can we characterize those planets and assess if they are habitable? The new field of extrasolar planet search has shown an extraordinary ability to combine research by astrophysics, chemistry, biology and geophysics into a new and exciting interdisciplinary approach to understand our place in the universe. The results of a first generation mission will most likely result in an amazing scope of diverse planets that will set planet formation, evolution as well as our planet in an overall context.

  12. Preprocessing Algorithm for Deciphering Historical Inscriptions Using String Metric

    Directory of Open Access Journals (Sweden)

    Lorand Lehel Toth

    2016-07-01

    Full Text Available The article presents the improvements in the preprocessing part of the deciphering method (shortly preprocessing algorithm for historical inscriptions of unknown origin. Glyphs used in historical inscriptions changed through time; therefore, various versions of the same script may contain different glyphs for each grapheme. The purpose of the preprocessing algorithm is reducing the running time of the deciphering process by filtering out the less probable interpretations of the examined inscription. However, the first version of the preprocessing algorithm leads incorrect outcome or no result in the output in certain cases. Therefore, its improved version was developed to find the most similar words in the dictionary by relaying the search conditions more accurately, but still computationally effectively. Moreover, a sophisticated similarity metric used to determine the possible meaning of the unknown inscription is introduced. The results of the evaluations are also detailed.

  13. [A sheet for deciphering the cries of hospitalized elderly patients].

    Science.gov (United States)

    Gomas, Jean-Marie; Tribout, Didier; Knorreck, Fanny; Denis, Michel; Petrognani, Annie; Sales, Elodie

    2014-01-01

    Crying out is not an insignificant act and it is important to fight against this misconception. Any caregiver can be confronted with this phenomenon with elderly hospitalised patients. Their cries must be understood, analysed and taken into account as they correspond to a particular situation experienced by the elderly patient. There are tools to help caregivers diagnose and reflect on this clinical context. This article presents the example of an interpretation sheet which can help caregivers decipher patients' cries.

  14. On a time-dependent extra spatial dimension

    CERN Document Server

    Kuhfittig, P K F

    2006-01-01

    In the usual brane-world scenario matter fields are confined to the four-dimensional spacetime, called a 3-brane, embedded in a higher-dimensional space, usually referred to as the bulk spacetime. In this paper we assume that the 3-brane a de Sitter space; there is only one extra spatial dimension, assumed to be time dependent. By using the form of the brane-world energy-momentum tensor suggested by Shiromizu et al. in the five-dimensional Einstein equations, it is shown that whenever the bulk cosmological constant \\Lambda is negative, the extra spatial dimension rapidly shrinks during the inflation of the brane. When \\Lambda>0, on the other hand, the extra spatial dimension either completely follows the cosmological expansion of the brane or completely ignores it. This behavior resembles the all-or-nothing behavior of ordinary systems in an expanding universe, as recently demonstrated by R.H. Price.

  15. Generation of Curvature Perturbations with Extra Anisotropic Stress

    CERN Document Server

    Kojima, Kazuhiko; Mathews, Grant J

    2009-01-01

    We study the evolution of curvature perturbations and the cosmic microwave background (CMB) power spectrum in the presence of an hypothesized extra anisotropic stress in the early universe. Such extra anisotropic stress terms might arise, for example, from the presence of the dark radiation term in brane-world cosmology. For the first time we evolve the scalar modes of such perturbations before and after neutrino decoupling and analyze their effects on the CMB spectrum. A novel result of this work is that the cancellation of the neutrino and extra anisotropic stress could lead to a spectrum of residual curvature perturbations which by themselves could reproduce the observed CMB power spectrum. This possibility may be testable as it would generate non-Gaussian fluctuations which could be constrained by future observations of density fluctuations.

  16. Black holes, cosmology and extra dimensions

    CERN Document Server

    Bronnikov, Kirill A

    2013-01-01

    Assuming foundational knowledge of special and general relativity, this book guides the reader on issues surrounding black holes, wormholes, cosmology, and extra dimensions. Its first part is devoted to local strong field configurations (black holes and wormholes) in general relativity and the most relevant of alternative theories: scalar-tensor, f(R) and multidimensional theories. The second part is on cosmology, including inflation and a unified description of the whole evolution of the universe. The third part concerns multidimensional theories of gravity and contains a number of original results obtained by the authors. Expository work is conducted for a mechanism of symmetries and fundamental constants formation, while the original approach to nonlinear multidimensional gravity that is able to construct a unique perspective describing different phenomena is highlighted. Much of the content is new in book publications, because it was previously found only in journal publications, e.g. regarding regular bl...

  17. Search for extra space dimensions with ATLAS

    Indian Academy of Sciences (India)

    Ambreesh Gupta; ATLAS Collaboration

    2004-03-01

    If extra spatial dimensions were to exist, they could provide a solution to the hierarchy problem. The studies done by the ATLAS Collaboration on the sensitivity of the detector to various extra dimension models are reported in this document.

  18. Universe

    CERN Document Server

    2011-01-01

    Updated for 2011, the Universe, is one book in the Britannica Illustrated Science Library Series that covers today's most popular science topics, from digital TV to microchips to touchscreens and beyond. Perennial subjects in earth science, life science, and physical science are all explored in detail. Amazing graphics-more than 1,000 per title-combined with concise summaries help students understand complex subjects. Correlated to the science curriculum in grades 5-9, each title also contains a glossary with full definitions for vocabulary.

  19. Universe

    CERN Document Server

    2009-01-01

    The Universe, is one book in the Britannica Illustrated Science Library Series that is correlated to the science curriculum in grades 5-8. The Britannica Illustrated Science Library is a visually compelling set that covers earth science, life science, and physical science in 16 volumes.  Created for ages 10 and up, each volume provides an overview on a subject and thoroughly explains it through detailed and powerful graphics-more than 1,000 per volume-that turn complex subjects into information that students can grasp.  Each volume contains a glossary with full definitions for vocabulary help and an index.

  20. Hangout with CERN: Extra dimensions (S03E02)

    CERN Multimedia

    Kahle, Kate

    2013-01-01

    Authors of two of the most cited papers in physics for the past ten years, this hangout features special guest theorists Lisa Randall from Harvard University and Raman Sundrum from University of Maryland, who join CERN physicists to look at how the LHC experiments are investigating extra dimensions.Our host, physicist Steven Goldfarb connects from the ATLAS experiment control centre with physicist Christophe Clement from Stockholm University, Sweden and Taylor Bayouth a CERN Visitor from Los Angeles, with Achintya Rao monitoring questions on social media. Also joining the discussion is CMS experiment physicist Sam Harper from Rutherford Appleton Laboratory, UK.Recorded live on 25th April 2013.

  1. The universal Higgs fit

    DEFF Research Database (Denmark)

    Giardino, P. P.; Kannike, K.; Masina, I.

    2014-01-01

    Higgs models, models with extra Higgs doublets, supersymmetry, extra particles in the loops, anomalous top couplings, and invisible Higgs decays into Dark Matter. Best fit regions lie around the Standard Model predictions and are well approximated by our 'universal' fit. Latest data exclude the dilaton...

  2. Light Stops from extra dimensions

    CERN Document Server

    Garcia-Pepin, Mateo

    2016-01-01

    In supersymmetric models the mass of the stops can be considered as the naturalness measure of the theory. Roughly, the lighter the stops are, the more natural the theory is. Both, the absence of supersymmetric signals at experiment and the measurement of the Higgs mass, put scenarios with light stops under increasing tension. I will present a supersymmetry breaking mechanism of the Scherk-Schwarz type that, by introducing extra $SU(2)_L$ triplets in the Higgs sector, is able to generate the correct Higgs mass while keeping stops light.

  3. Higgs Bosons in Extra Dimensions

    CERN Document Server

    Quiros, Mariano

    2015-01-01

    In this paper, motivated by the recent discovery of a Higgs-like boson at the LHC with a mass m_H\\simeq 126 GeV, we review different models where the hierarchy problem is solved by means of a warped extra dimension. In the Randall-Sundrum model electroweak observables provide very strong bounds on the mass of KK modes which motivates extensions to overcome this problem. Two extensions are briefly discussed. One particular extension is based on the deformation of the metric such that it strongly departs from the AdS_5 structure in the IR region while it goes asymptotically to AdS_5 in the UV brane. This model has the IR brane close to a naked metric singularity (which is outside the physical interval) characteristic of soft-walls constructions. The proximity of the singularity provides a strong wave-function renormalization for the Higgs field which suppresses the T and S parameters. The second class of considered extensions are based on the introduction of an extra gauge group in the bulk such that the custod...

  4. Deciphering Parameter Sensitivity in the BvgAS Signal Transduction

    Science.gov (United States)

    Mapder, Tarunendu; Talukder, Srijeeta; Chattopadhyay, Sudip; Banik, Suman K.

    2016-01-01

    To understand the switching of different phenotypic phases of Bordetella pertussis, we propose an optimized mathematical framework for signal transduction through BvgAS two-component system. The response of the network output to the sensory input has been demonstrated in steady state. An analysis in terms of local sensitivity amplification characterizes the nature of the molecular switch. The sensitivity analysis of the model parameters within the framework of various correlation coefficients helps to decipher the contribution of the modular structure in signal propagation. Once classified, the model parameters are tuned to generate the behavior of some novel strains using simulated annealing, a stochastic optimization technique. PMID:26812153

  5. Deciphering Parameter Sensitivity in the BvgAS Signal Transduction.

    Directory of Open Access Journals (Sweden)

    Tarunendu Mapder

    Full Text Available To understand the switching of different phenotypic phases of Bordetella pertussis, we propose an optimized mathematical framework for signal transduction through BvgAS two-component system. The response of the network output to the sensory input has been demonstrated in steady state. An analysis in terms of local sensitivity amplification characterizes the nature of the molecular switch. The sensitivity analysis of the model parameters within the framework of various correlation coefficients helps to decipher the contribution of the modular structure in signal propagation. Once classified, the model parameters are tuned to generate the behavior of some novel strains using simulated annealing, a stochastic optimization technique.

  6. Deciphering Parameter Sensitivity in the BvgAS Signal Transduction.

    Science.gov (United States)

    Mapder, Tarunendu; Talukder, Srijeeta; Chattopadhyay, Sudip; Banik, Suman K

    2016-01-01

    To understand the switching of different phenotypic phases of Bordetella pertussis, we propose an optimized mathematical framework for signal transduction through BvgAS two-component system. The response of the network output to the sensory input has been demonstrated in steady state. An analysis in terms of local sensitivity amplification characterizes the nature of the molecular switch. The sensitivity analysis of the model parameters within the framework of various correlation coefficients helps to decipher the contribution of the modular structure in signal propagation. Once classified, the model parameters are tuned to generate the behavior of some novel strains using simulated annealing, a stochastic optimization technique.

  7. Materia extraña

    CERN Document Server

    Gómez Cadenas, J J

    2008-01-01

    Enero, 1999. Unas extrañas burbujas se han colocado en el acelerador de particulas del CERN (Ginebra). Ante el riesgo de que esto desencadene una catástrofe a escala mundial, el centro ordena detener el experimento. Años después, Irene, una joven y promotedora científica, es contratada en la división de Física Teórica del CERN. Allí coincide con el mayor Espinosa, destinado a la sede suiza de la ONU para trabajar en un proyecto contra la proliferación de armas nucleares. La misión de Espinosa resulta ser mucho más arriesgada de lo que parecía. Irene ambiciosa y rebelde, toma una decisión de efectos imprevisibles.

  8. Envirotyping for deciphering environmental impacts on crop plants.

    Science.gov (United States)

    Xu, Yunbi

    2016-04-01

    Global climate change imposes increasing impacts on our environments and crop production. To decipher environmental impacts on crop plants, the concept "envirotyping" is proposed, as a third "typing" technology, complementing with genotyping and phenotyping. Environmental factors can be collected through multiple environmental trials, geographic and soil information systems, measurement of soil and canopy properties, and evaluation of companion organisms. Envirotyping contributes to crop modeling and phenotype prediction through its functional components, including genotype-by-environment interaction (GEI), genes responsive to environmental signals, biotic and abiotic stresses, and integrative phenotyping. Envirotyping, driven by information and support systems, has a wide range of applications, including environmental characterization, GEI analysis, phenotype prediction, near-iso-environment construction, agronomic genomics, precision agriculture and breeding, and development of a four-dimensional profile of crop science involving genotype (G), phenotype (P), envirotype (E) and time (T) (developmental stage). In the future, envirotyping needs to zoom into specific experimental plots and individual plants, along with the development of high-throughput and precision envirotyping platforms, to integrate genotypic, phenotypic and envirotypic information for establishing a high-efficient precision breeding and sustainable crop production system based on deciphered environmental impacts.

  9. Deciphering the evolutionary history of open and closed mitosis.

    Science.gov (United States)

    Sazer, Shelley; Lynch, Michael; Needleman, Daniel

    2014-11-17

    The origin of the nucleus at the prokaryote-to-eukaryote transition represents one of the most important events in the evolution of cellular organization. The nuclear envelope encircles the chromosomes in interphase and is a selectively permeable barrier between the nucleoplasm and cytoplasm and an organizational scaffold for the nucleus. It remains intact in the 'closed' mitosis of some yeasts, but loses its integrity in the 'open' mitosis of mammals. Instances of both types of mitosis within two evolutionary clades indicate multiple evolutionary transitions between open and closed mitosis, although the underlying genetic changes that influenced these transitions remain unknown. A survey of the diversity of mitotic nuclei that fall between these extremes is the starting point from which to determine the physiologically relevant characteristics distinguishing open from closed mitosis and to understand how they evolved and why they are retained in present-day organisms. The field is now poised to begin addressing these issues by defining and documenting patterns of mitotic nuclear variation within and among species and mapping them onto a phylogenic tree. Deciphering the evolutionary history of open and closed mitosis will complement cell biological and genetic approaches aimed at deciphering the fundamental organizational principles of the nucleus.

  10. Exploring Extra Dimensions in Spectroscopy Experiments

    Institute of Scientific and Technical Information of China (English)

    LUO Feng; LIU Hong-Ya

    2006-01-01

    @@ We propose an idea in spectroscopy to search for extra spatial dimensions as well as to detect the possible deviation from Newton's inverse-square law at small scale, and we take high-Z hydrogenic systems and muonic atoms as illustrations. The relevant experiments might help to explore a more than two extra dimensions scenario in the brane world model proposed by Arkani-Hamed, Dimopoulos, Dvali (ADD) and to set constraints for fundamental parameters such as the size of extra dimensions.

  11. Extra and intradural spinal Hemangioblastoma Hemangioblastoma espinal extra e intradural Hemangioblastoma espinhal extra e intradural

    Directory of Open Access Journals (Sweden)

    Marcelo Campos Moraes Amato

    2012-09-01

    Full Text Available Hemangioblastomas of the central nervous system (CNS are low-grade highly vascularized tumors that may be sporadic or associated with Von Hippel-Lindau disease. Extradural hemangioblastomas are uncommon and those located extra and intradurally are even rarer. This study uses an illustrative case and literature review to discuss the difficulties to consider the correct diagnosis and to select the best surgical approach. A 57 years-old white male patient presented with myelopathy and right C5 radiculopathy. The images showed a lobulated, hourglass shaped, highly enhanced extra/intradural lesion that occupied the spinal canal and widened the C4-C5 right intervertebral foramen. Total resection of the intradural lesion was achieved through a posterior approach, but the extradural part could only be partially removed. Complete improvement was observed after four months of follow-up and the residual tumor has been followed up clinically and radiologically. Even though the preoperative impression was of a spinal schwannoma, the histopathological examination revealed grade I hemangioblastoma as per WHO. Despite their rarity, current complementary exams allow considering the diagnosis of hemangioblastoma preoperatively. That is essential to a better surgical planning in view of the particular surgical features of this lesion.Hemangioblastomas del sistema nervioso central (SNC son tumores altamente vascularizados, de grado bajo, que pueden ser esporádicos o vinculados a la enfermedad de Von Hippel-Lindau. Hemangioblastomas extradurales no son comunes, y aquellos localizados extra e intraduralmente son aún más raros. Este estudio usa un caso ilustrativo y la revisión de la literatura para analizar las dificultades cuanto a considerar el diagnóstico correcto y para seleccionar el mejor abordaje quirúrgico. Un paciente, hombre blanco de 57 años de edad, presentaba mielopatía con radiculopatía C5 derecha. Las imágenes mostraban lesión extra

  12. Extra informatie op matrixborden : mogelijkheden en effecten.

    NARCIS (Netherlands)

    Craen, S. de & Niet, M. de

    2002-01-01

    In this report, the possibilities of displaying extra safety information on Dynamic Message Signs (DMSs) are explored. The technical possibilities for placing extra information on the signs are looked at, and the road safety effects are examined. The information to be displayed can be divided into t

  13. Extra dimensions at particle colliders

    Energy Technology Data Exchange (ETDEWEB)

    Dvergsnes, Erik Wolden

    2004-08-01

    This thesis consists of an introduction where we consider different aspects of theories involving extra dimensions, together with four research publications (Papers I-IV) attached at the end. The introductional chapters should serve as background material for better understanding the models on which the articles are based. In Chap. 4 we also present some plots not included in the papers. The topic of Papers I-III is graviton induced Bremsstrahlung. In Paper I we consider the contribution to this process from graviton exchange through gluon-gluon fusion at the LHC, compared to the QED background. Only final-state radiation is considered in Paper I, whereas in Paper II we extend this work to include also the quark-antiquark annihilation with graviton exchange, as well as initial-state radiation for both graviton and Standard Model exchange. Paper III is a study of graviton-induced Bremsstrahlung at e{sup +}e{sup -} colliders, including both initial- and final-state radiation. Paper IV is devoted to a study of the center-edge asymmetry at hadron colliders, an asymmetry which previously had been studied for e{sup +}e{sup -} colliders. The center-edge asymmetry can be used as a method of distinguishing between spin-1 and spin-2 exchange, something which will be of major importance if a signal is observed.

  14. Twenty years of protein interaction studies for biological function deciphering.

    Science.gov (United States)

    Legrain, Pierre; Rain, Jean-Christophe

    2014-07-31

    Intensive methodological developments and technology innovation have been devoted to protein-protein interaction studies over 20years. Genetic indirect assays and sophisticated large scale biochemical analyses have jointly contributed to the elucidation of protein-protein interactions, still with a lot of drawbacks despite heavy investment in human resources and technologies. With the most recent developments in mass spectrometry and computational tools for studying protein content of complex samples, the initial goal of deciphering molecular bases of biological functions is now within reach. Here, we described the various steps of this process and gave examples of key milestones in this scientific story line. This article is part of a Special Issue entitled: 20years of Proteomics in memory of Viatliano Pallini. Guest Editors: Luca Bini, Juan J. Calvete, Natacha Turck, Denis Hochstrasser and Jean-Charles Sanchez.

  15. A bulk inflaton from large volume extra dimensions

    CERN Document Server

    Greene, Brian; Levin, Janna; Thurston, Dylan

    2010-01-01

    The universe may have extra spatial dimensions with large volume that we cannot perceive because the energy required to excite modes in the extra directions is too high. Many examples are known of such manifolds with a large volume and a large mass gap. These compactifications can help explain the weakness of four-dimensional gravity and, as we show here, they also have the capacity to produce reasonable potentials for an inflaton field. Modeling the inflaton as a bulk scalar field, it becomes very weakly coupled in four dimensions, and this enables us to build phenomenologically acceptable inflationary models with tunings at the few per mil level. We speculate on dark matter candidates and the possibility of braneless models in this setting.

  16. A bulk inflaton from large-volume extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Greene, Brian, E-mail: greene@physics.columbia.ed [Institute for Strings, Cosmology and Astroparticle Physics (ISCAP), Columbia University, New York, NY 10027 (United States); Departments of Physics and Mathematics, Columbia University, New York, NY 10027 (United States); Kabat, Daniel, E-mail: daniel.kabat@lehman.cuny.ed [Department of Physics and Astronomy, Lehman College, CUNY, Bronx, NY 10468 (United States); Levin, Janna, E-mail: janna@astro.columbia.ed [Institute for Strings, Cosmology and Astroparticle Physics (ISCAP), Columbia University, New York, NY 10027 (United States); Department of Physics and Astronomy, Barnard College, Columbia University, New York, NY 10027 (United States); Thurston, Dylan, E-mail: dpt@cpw.math.columbia.ed [Department of Mathematics, Barnard College, Columbia University, New York, NY 10027 (United States)

    2011-01-03

    The universe may have extra spatial dimensions with large volume that we cannot perceive because the energy required to excite modes in the extra directions is too high. Many examples are known of manifolds with a large volume and a large mass gap. These compactifications can help explain the weakness of four-dimensional gravity and, as we show here, they also have the capacity to produce reasonable potentials for an inflaton field. Modeling the inflaton as a bulk scalar field, it becomes very weakly coupled in four dimensions and this enables us to build phenomenologically acceptable inflationary models with tunings at the few per mil level. We speculate on dark matter candidates and the possibility of braneless models in this setting.

  17. Deciphering Transcriptional Dynamics In Vivo by Counting Nascent RNA Molecules.

    Science.gov (United States)

    Choubey, Sandeep; Kondev, Jane; Sanchez, Alvaro

    2015-11-01

    Deciphering how the regulatory DNA sequence of a gene dictates its expression in response to intra and extracellular cues is one of the leading challenges in modern genomics. The development of novel single-cell sequencing and imaging techniques, as well as a better exploitation of currently available single-molecule imaging techniques, provides an avenue to interrogate the process of transcription and its dynamics in cells by quantifying the number of RNA polymerases engaged in the transcription of a gene (or equivalently the number of nascent RNAs) at a given moment in time. In this paper, we propose that measurements of the cell-to-cell variability in the number of nascent RNAs provide a mostly unexplored method for deciphering mechanisms of transcription initiation in cells. We propose a simple kinetic model of transcription initiation and elongation from which we calculate nascent RNA copy-number fluctuations. To demonstrate the usefulness of this approach, we test our theory against published nascent RNA data for twelve constitutively expressed yeast genes. Rather than transcription being initiated through a single rate limiting step, as it had been previously proposed, our single-cell analysis reveals the presence of at least two rate limiting steps. Surprisingly, half of the genes analyzed have nearly identical rates of transcription initiation, suggesting a common mechanism. Our analytical framework can be used to extract quantitative information about dynamics of transcription from single-cell sequencing data, as well as from single-molecule imaging and electron micrographs of fixed cells, and provides the mathematical means to exploit the quantitative power of these technologies.

  18. Deciphering Transcriptional Dynamics In Vivo by Counting Nascent RNA Molecules.

    Directory of Open Access Journals (Sweden)

    Sandeep Choubey

    2015-11-01

    Full Text Available Deciphering how the regulatory DNA sequence of a gene dictates its expression in response to intra and extracellular cues is one of the leading challenges in modern genomics. The development of novel single-cell sequencing and imaging techniques, as well as a better exploitation of currently available single-molecule imaging techniques, provides an avenue to interrogate the process of transcription and its dynamics in cells by quantifying the number of RNA polymerases engaged in the transcription of a gene (or equivalently the number of nascent RNAs at a given moment in time. In this paper, we propose that measurements of the cell-to-cell variability in the number of nascent RNAs provide a mostly unexplored method for deciphering mechanisms of transcription initiation in cells. We propose a simple kinetic model of transcription initiation and elongation from which we calculate nascent RNA copy-number fluctuations. To demonstrate the usefulness of this approach, we test our theory against published nascent RNA data for twelve constitutively expressed yeast genes. Rather than transcription being initiated through a single rate limiting step, as it had been previously proposed, our single-cell analysis reveals the presence of at least two rate limiting steps. Surprisingly, half of the genes analyzed have nearly identical rates of transcription initiation, suggesting a common mechanism. Our analytical framework can be used to extract quantitative information about dynamics of transcription from single-cell sequencing data, as well as from single-molecule imaging and electron micrographs of fixed cells, and provides the mathematical means to exploit the quantitative power of these technologies.

  19. Paraganglioma funcional extra-adrenal

    Directory of Open Access Journals (Sweden)

    Laura Arroyo-Martínez

    2006-03-01

    Full Text Available Los paragangliomas funcionales son tumores raros, se originan del tejido cromafín extraadrenal productor de catecolaminas, con frecuencia son malignos y tienen alta incidencia de enfermedad persistente o recurrente¹. Se les conoce como: glomus, quemodectomas, paragangliomas cromafines y glomerulocitomas. La localización es diversa y refleja la distribución paraganglionar en el cuerpo, desde la base del cráneo hasta el piso pélvico. Los paragangliomas se encuentran en donde hay ganglios del sistema autónomo, sin embargo, aproximadamente el 90% de estos tumores aparecen en las glándulas suprarrenales (y constituyen los feocromocitomas y el 10% restante tienen una ubicación extraadrenal, mas se ha dicho que su incidencia puede ser subestimada, variando del 18% al 22% en adultos, y en niños hasta un 30%. Los extra-adrenales se originan con mayor frecuencia en el abdomen (85%, otros en el tórax (12% y más raramente en la cabeza y el cuello (3% ². Los estudios de imágenes y la medición de la producción no fisiológica de catecolaminas pueden ayudar en el diagnóstico de esta entidad. La cirugía es el tratamiento de elección. Presentamos aquí el caso de una paciente de 32 años, primigesta con HTAIE que requirió cesárea, quien tuvo un postparto tórpido y pese a múltiples tratamientos antihipertensivos su patología fue de difícil manejo, con complicaciones oftálmicas. Tiempo después la paciente se estudia por hiperhidrosis, se solicitan exámenes de laboratorio e imágenes y se le documenta incidentalmente, una tumoración retroperitoneal izquierda, se le amplían los estudios, y se llega al diagnóstico correcto. La tumoración requirió resección quirúrgica. Tuvo un postoperatorio satisfactorio y la paciente egresó con control en la Consulta Externa.Functioning paragangliomas are rare tumors that produce catecholamines. They originate from extra-adrenal chromaffin cells. They are frequentIy malignant and are associated

  20. Paraganglioma funcional extra-adrenal

    Directory of Open Access Journals (Sweden)

    Laura Arroyo-Martínez

    2006-03-01

    Full Text Available Los paragangliomas funcionales son tumores raros, se originan del tejido cromafín extraadrenal productor de catecolaminas, con frecuencia son malignos y tienen alta incidencia de enfermedad persistente o recurrente¹. Se les conoce como: glomus, quemodectomas, paragangliomas cromafines y glomerulocitomas. La localización es diversa y refleja la distribución paraganglionar en el cuerpo, desde la base del cráneo hasta el piso pélvico. Los paragangliomas se encuentran en donde hay ganglios del sistema autónomo, sin embargo, aproximadamente el 90% de estos tumores aparecen en las glándulas suprarrenales (y constituyen los feocromocitomas y el 10% restante tienen una ubicación extraadrenal, mas se ha dicho que su incidencia puede ser subestimada, variando del 18% al 22% en adultos, y en niños hasta un 30%. Los extra-adrenales se originan con mayor frecuencia en el abdomen (85%, otros en el tórax (12% y más raramente en la cabeza y el cuello (3% ². Los estudios de imágenes y la medición de la producción no fisiológica de catecolaminas pueden ayudar en el diagnóstico de esta entidad. La cirugía es el tratamiento de elección. Presentamos aquí el caso de una paciente de 32 años, primigesta con HTAIE que requirió cesárea, quien tuvo un postparto tórpido y pese a múltiples tratamientos antihipertensivos su patología fue de difícil manejo, con complicaciones oftálmicas. Tiempo después la paciente se estudia por hiperhidrosis, se solicitan exámenes de laboratorio e imágenes y se le documenta incidentalmente, una tumoración retroperitoneal izquierda, se le amplían los estudios, y se llega al diagnóstico correcto. La tumoración requirió resección quirúrgica. Tuvo un postoperatorio satisfactorio y la paciente egresó con control en la Consulta Externa.

  1. Extra dimensions in space and time

    CERN Document Server

    Bars, Itzhak

    2010-01-01

    Covers topics such as Einstein and the Fourth Dimension; Waves in a Fifth Dimension; and String Theory and Branes Experimental Tests of Extra Dimensions. This book offers a discussion on Two-Time Physics

  2. Muon colliders, frictional cooling and universal extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Greenwald, Daniel E.

    2011-07-20

    A muon collider combines the advantages of proton-proton and electron-positron colliders, sidestepping many of their disadvantages, and has the potential to make discoveries and precision measurements at high energies. However, muons bring their own technical challenges, largely relating to their instability. We present a summary of the motivations and R and D efforts for a muon collider. We detail a scheme for preparing high-luminosity muon beams on timescales shorter than the muon lifetime, and an experiment to demonstrate aspects of this scheme at the Max Planck Institute for Physics. We also investigate the potentials to discover physics beyond the standard model at a muon collider. (orig.)

  3. Pasta de azeite versus azeite virgem extra

    OpenAIRE

    Dias, Susana Marisa da Cunha

    2009-01-01

    Mestrado em Engenharia Alimentar - Instituto Superior de Agronomia Innovative products of high nutritional quality, with healthy benefits and extended conservation are an asset to the food sector. With beneficial health properties and high nutritional quality, extra virgin olive oil is an extraordinary fat, thanks to its unique chemical composition. The olive oil spread, subject of this study, is an innovative product, created from extra virgin olive oil, with a consistency ...

  4. Deciphering Jupiter's atmospheric dynamics using the upcoming Juno gravity measurements

    Science.gov (United States)

    Kaspi, Yohai; Galanti, Eli

    2016-07-01

    This summer, the Juno spacecraft will arrive at Jupiter in course for close flybys of the planet, obtaining a high precision gravity spectrum of Jupiter. This data can be used to estimate the depth of Jupiter's observed cloud-level wind, and decipher the possible internal flows, that might be decoupled from the surface wind. In this talk, we discuss the Juno gravity experiment, and the possible outcomes with regard to the flows on Jupiter. We show several ways in which the gravity spectrum might be used to study the large scale flows: 1. measurements of the high order even harmonics which beyond J10 are dominated by the dynamics; 2. measurements of odd gravity harmonics which have no contribution from a static planet, and therefore are a pure signature of dynamics; 3. upper limits on the depth of the surface flow can be obtained by comparing low order even harmonics from dynamical models to the difference between the measured low order even harmonics and the largest possible values of a static planet; 4. direct latitudinally varying measurements of the gravity field exerted on the spacecraft. We will discuss how these methods may be applied given the expected sensitivities of the Juno gravity experiment. In addition, we present an inverse adjoint model, which allows given the gravity data, to infer the flows that produce it. This will allow, hopefully, to make significant progress in one of the longest-standing question in planetary atmospheric dynamics regarding the nature of the flows on the giant planets.

  5. Deciphering fluid inclusions in high-grade rocks

    Directory of Open Access Journals (Sweden)

    Alfons van den Kerkhof

    2014-09-01

    Full Text Available The study of fluid inclusions in high-grade rocks is especially challenging as the host minerals have been normally subjected to deformation, recrystallization and fluid-rock interaction so that primary inclusions, formed at the peak of metamorphism are rare. The larger part of the fluid inclusions found in metamorphic minerals is typically modified during uplift. These late processes may strongly disguise the characteristics of the “original” peak metamorphic fluid. A detailed microstructural analysis of the host minerals, notably quartz, is therefore indispensable for a proper interpretation of fluid inclusions. Cathodoluminescence (CL techniques combined with trace element analysis of quartz (EPMA, LA-ICPMS have shown to be very helpful in deciphering the rock-fluid evolution. Whereas high-grade metamorphic quartz may have relatively high contents of trace elements like Ti and Al, low-temperature re-equilibrated quartz typically shows reduced trace element concentrations. The resulting microstructures in CL can be basically distinguished in diffusion patterns (along microfractures and grain boundaries, and secondary quartz formed by dissolution-reprecipitation. Most of these textures are formed during retrograde fluid-controlled processes between ca. 220 and 500 °C, i.e. the range of semi-brittle deformation (greenschist-facies and can be correlated with the fluid inclusions. In this way modified and re-trapped fluids can be identified, even when there are no optical features observed under the microscope.

  6. Deciphering Antarctic Intermediate Water Variability during the PLIO-PLEISTOCENE

    Science.gov (United States)

    Karas, C.; deMenocal, P. B.; Goldstein, S. L.

    2015-12-01

    Antarctic Intermediate Water (AAIW) plays a fundamental role in the modern global thermohaline circulation because it is the coldwater route from the Southern Hemisphere to the North Atlantic Ocean replacing North Atlantic Deep Water (NADW) (e.g. Oppo and Curry, 2012). Additionally, AAIW is also an important source water in (sub)tropical upwelling regions in the equatorial eastern Pacific and Benguela region (Kubota et al., 2014; Sarmiento et al., 2004). Deciphering AAIW variability through time is critical to understanding its role in global climate change (e.g. Santoso and England, 2004). Our study focuses on reconstructing AAIW during the warm Pliocene (~4 million years ago) and early Pleistocene. This time period marks the transition from warm Pliocene greenhouse conditions towards icehouse conditions, which most likely affected AAIW variability (Karas et al., 2011). To reconstruct changes in AAIW formation, northward extent and possible influence on (sub)tropical upwelling regions, we will use foraminiferal neodymium isotopes (ɛNd) and benthic Mg/Ca from South Atlantic Site 516 and Southwest Pacific Site 1125.

  7. Deciphering the pathogenesis of tendinopathy: a three-stages process

    Directory of Open Access Journals (Sweden)

    Fu Sai-Chuen

    2010-12-01

    Full Text Available Abstract Our understanding of the pathogenesis of "tendinopathy" is based on fragmented evidences like pieces of a jigsaw puzzle. We propose a "failed healing theory" to knit these fragments together, which can explain previous observations. We also propose that albeit "overuse injury" and other insidious "micro trauma" may well be primary triggers of the process, "tendinopathy" is not an "overuse injury" per se. The typical clinical, histological and biochemical presentation relates to a localized chronic pain condition which may lead to tendon rupture, the latter attributed to mechanical weakness. Characterization of pathological "tendinotic" tissues revealed coexistence of collagenolytic injuries and an active healing process, focal hypervascularity and tissue metaplasia. These observations suggest a failed healing process as response to a triggering injury. The pathogenesis of tendinopathy can be described as a three stage process: injury, failed healing and clinical presentation. It is likely that some of these "initial injuries" heal well and we speculate that predisposing intrinsic or extrinsic factors may be involved. The injury stage involves a progressive collagenolytic tendon injury. The failed healing stage mainly refers to prolonged activation and failed resolution of the normal healing process. Finally, the matrix disturbances, increased focal vascularity and abnormal cytokine profiles contribute to the clinical presentations of chronic tendon pain or rupture. With this integrative pathogenesis theory, we can relate the known manifestations of tendinopathy and point to the "missing links". This model may guide future research on tendinopathy, until we could ultimately decipher the complete pathogenesis process and provide better treatments.

  8. Deciphering the pathogenesis of tendinopathy: a three-stages process

    Science.gov (United States)

    2010-01-01

    Our understanding of the pathogenesis of "tendinopathy" is based on fragmented evidences like pieces of a jigsaw puzzle. We propose a "failed healing theory" to knit these fragments together, which can explain previous observations. We also propose that albeit "overuse injury" and other insidious "micro trauma" may well be primary triggers of the process, "tendinopathy" is not an "overuse injury" per se. The typical clinical, histological and biochemical presentation relates to a localized chronic pain condition which may lead to tendon rupture, the latter attributed to mechanical weakness. Characterization of pathological "tendinotic" tissues revealed coexistence of collagenolytic injuries and an active healing process, focal hypervascularity and tissue metaplasia. These observations suggest a failed healing process as response to a triggering injury. The pathogenesis of tendinopathy can be described as a three stage process: injury, failed healing and clinical presentation. It is likely that some of these "initial injuries" heal well and we speculate that predisposing intrinsic or extrinsic factors may be involved. The injury stage involves a progressive collagenolytic tendon injury. The failed healing stage mainly refers to prolonged activation and failed resolution of the normal healing process. Finally, the matrix disturbances, increased focal vascularity and abnormal cytokine profiles contribute to the clinical presentations of chronic tendon pain or rupture. With this integrative pathogenesis theory, we can relate the known manifestations of tendinopathy and point to the "missing links". This model may guide future research on tendinopathy, until we could ultimately decipher the complete pathogenesis process and provide better treatments. PMID:21144004

  9. Deciphering modular and dynamic behaviors of transcriptional networks.

    Science.gov (United States)

    Zhan, Ming

    2007-01-01

    The coordinated and dynamic modulation or interaction of genes or proteins acts as an important mechanism used by a cell in functional regulation. Recent studies have shown that many transcriptional networks exhibit a scale-free topology and hierarchical modular architecture. It has also been shown that transcriptional networks or pathways are dynamic and behave only in certain ways and controlled manners in response to disease development, changing cellular conditions, and different environmental factors. Moreover, evolutionarily conserved and divergent transcriptional modules underline fundamental and species-specific molecular mechanisms controlling disease development or cellular phenotypes. Various computational algorithms have been developed to explore transcriptional networks and modules from gene expression data. In silico studies have also been made to mimic the dynamic behavior of regulatory networks, analyzing how disease or cellular phenotypes arise from the connectivity or networks of genes and their products. Here, we review the recent development in computational biology research on deciphering modular and dynamic behaviors of transcriptional networks, highlighting important findings. We also demonstrate how these computational algorithms can be applied in systems biology studies as on disease, stem cells, and drug discovery.

  10. The Bromodomain and Extra-Terminal Domain (BET Family: Functional Anatomy of BET Paralogous Proteins

    Directory of Open Access Journals (Sweden)

    Yasushi Taniguchi

    2016-11-01

    Full Text Available The Bromodomain and Extra-Terminal Domain (BET family of proteins is characterized by the presence of two tandem bromodomains and an extra-terminal domain. The mammalian BET family of proteins comprises BRD2, BRD3, BRD4, and BRDT, which are encoded by paralogous genes that may have been generated by repeated duplication of an ancestral gene during evolution. Bromodomains that can specifically bind acetylated lysine residues in histones serve as chromatin-targeting modules that decipher the histone acetylation code. BET proteins play a crucial role in regulating gene transcription through epigenetic interactions between bromodomains and acetylated histones during cellular proliferation and differentiation processes. On the other hand, BET proteins have been reported to mediate latent viral infection in host cells and be involved in oncogenesis. Human BRD4 is involved in multiple processes of the DNA virus life cycle, including viral replication, genome maintenance, and gene transcription through interaction with viral proteins. Aberrant BRD4 expression contributes to carcinogenesis by mediating hyperacetylation of the chromatin containing the cell proliferation-promoting genes. BET bromodomain blockade using small-molecule inhibitors gives rise to selective repression of the transcriptional network driven by c-MYC These inhibitors are expected to be potential therapeutic drugs for a wide range of cancers. This review presents an overview of the basic roles of BET proteins and highlights the pathological functions of BET and the recent developments in cancer therapy targeting BET proteins in animal models.

  11. Extra-oral halitosis: an overview.

    Science.gov (United States)

    Tangerman, A; Winkel, E G

    2010-03-01

    Halitosis can be subdivided into intra-oral and extra-oral halitosis, depending on the place where it originates. Most reports now agree that the most frequent sources of halitosis exist within the oral cavity and include bacterial reservoirs such as the dorsum of the tongue, saliva and periodontal pockets, where anaerobic bacteria degrade sulfur-containing amino acids to produce the foul smelling volatile sulfur compounds (VSCs), especially hydrogen sulfide (H(2)S) and methyl mercaptan (CH(3)SH). Tongue coating is considered to be the most important source of VSCs. Oral malodor can now be treated effectively. Special attention in this overview is given to extra-oral halitosis. Extra-oral halitosis can be subdivided into non-blood-borne halitosis, such as halitosis from the upper respiratory tract including the nose and from the lower respiratory tract, and blood-borne halitosis. The majority of patients with extra-oral halitosis have blood-borne halitosis. Blood-borne halitosis is also frequently caused by odorous VSCs, in particular dimethyl sulfide (CH3SCH3). Extra-oral halitosis, covering about 5-10% of all cases of halitosis, might be a manifestation of a serious disease for which treatment is much more complicated than for intra-oral halitosis. It is therefore of utmost importance to differentiate between intra-oral and extra-oral halitosis. Differences between intra-oral and extra-oral halitosis are discussed extensively. The importance of applying odor characterization of various odorants in halitosis research is also highlighted in this article. The use of the odor index, odor threshold values and simulation of bad breath samples is explained.

  12. Dark Energy as Evidence for Extra Dimensions

    CERN Document Server

    Milton, K A

    2003-01-01

    It is argued that fluctuations of quantum fields in four-dimensional space do not give rise to dark energy, but are rather a negligible contribution to dark matter. By (relativistic) dark matter we mean that the relation between pressure and energy density is $p=\\frac13 u$, while dark energy is characterized by $p=-u$. A possible source of dark energy are the fluctuations in quantum fields, including quantum gravity, inhabiting extra compactified dimensions. These fluctuations have been computed for some simple geometries, such as $S^2$, $S^4$, and $S^6$. If the extra dimensions are too small, they would give rise to a dark energy larger than that observed, whereas if they are too large they would be in conflict with experimental tests of Newton's law. This notion suggests that the size of the extra dimensions is of order 100 $\\mu$m. If the limit on the size of extra dimensions becomes lower than this bound, extra dimensions probably do not exist, and another source for cosmological dark energy will have to b...

  13. A computational approach for deciphering the organization of glycosaminoglycans.

    Directory of Open Access Journals (Sweden)

    Jean L Spencer

    computational tools to use to assess patterns of domain organization within glycosaminoglycans. These tools will provide a means to consider high-level chain organization in deciphering the structure-function relationships of polysaccharides in biology.

  14. Sequential logic model deciphers dynamic transcriptional control of gene expressions.

    Directory of Open Access Journals (Sweden)

    Zhen Xuan Yeo

    Full Text Available BACKGROUND: Cellular signaling involves a sequence of events from ligand binding to membrane receptors through transcription factors activation and the induction of mRNA expression. The transcriptional-regulatory system plays a pivotal role in the control of gene expression. A novel computational approach to the study of gene regulation circuits is presented here. METHODOLOGY: Based on the concept of finite state machine, which provides a discrete view of gene regulation, a novel sequential logic model (SLM is developed to decipher control mechanisms of dynamic transcriptional regulation of gene expressions. The SLM technique is also used to systematically analyze the dynamic function of transcriptional inputs, the dependency and cooperativity, such as synergy effect, among the binding sites with respect to when, how much and how fast the gene of interest is expressed. PRINCIPAL FINDINGS: SLM is verified by a set of well studied expression data on endo16 of Strongylocentrotus purpuratus (sea urchin during the embryonic midgut development. A dynamic regulatory mechanism for endo16 expression controlled by three binding sites, UI, R and Otx is identified and demonstrated to be consistent with experimental findings. Furthermore, we show that during transition from specification to differentiation in wild type endo16 expression profile, SLM reveals three binary activities are not sufficient to explain the transcriptional regulation of endo16 expression and additional activities of binding sites are required. Further analyses suggest detailed mechanism of R switch activity where indirect dependency occurs in between UI activity and R switch during specification to differentiation stage. CONCLUSIONS/SIGNIFICANCE: The sequential logic formalism allows for a simplification of regulation network dynamics going from a continuous to a discrete representation of gene activation in time. In effect our SLM is non-parametric and model-independent, yet

  15. Deciphering neuronal population codes for acute thermal pain

    Science.gov (United States)

    Chen, Zhe; Zhang, Qiaosheng; Phuong Sieu Tong, Ai; Manders, Toby R.; Wang, Jing

    2017-06-01

    Objective. Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Current pain research mostly focuses on molecular and synaptic changes at the spinal and peripheral levels. However, a complete understanding of pain mechanisms requires the physiological study of the neocortex. Our goal is to apply a neural decoding approach to read out the onset of acute thermal pain signals, which can be used for brain-machine interface. Approach. We used micro wire arrays to record ensemble neuronal activities from the primary somatosensory cortex (S1) and anterior cingulate cortex (ACC) in freely behaving rats. We further investigated neural codes for acute thermal pain at both single-cell and population levels. To detect the onset of acute thermal pain signals, we developed a novel latent state-space framework to decipher the sorted or unsorted S1 and ACC ensemble spike activities, which reveal information about the onset of pain signals. Main results. The state space analysis allows us to uncover a latent state process that drives the observed ensemble spike activity, and to further detect the ‘neuronal threshold’ for acute thermal pain on a single-trial basis. Our method achieved good detection performance in sensitivity and specificity. In addition, our results suggested that an optimal strategy for detecting the onset of acute thermal pain signals may be based on combined evidence from S1 and ACC population codes. Significance. Our study is the first to detect the onset of acute pain signals based on neuronal ensemble spike activity. It is important from a mechanistic viewpoint as it relates to the significance of S1 and ACC activities in the regulation of the acute pain onset.

  16. Functional metagenomics to decipher food-microbe-host crosstalk.

    Science.gov (United States)

    Larraufie, Pierre; de Wouters, Tomas; Potocki-Veronese, Gabrielle; Blottière, Hervé M; Doré, Joël

    2015-02-01

    The recent developments of metagenomics permit an extremely high-resolution molecular scan of the intestinal microbiota giving new insights and opening perspectives for clinical applications. Beyond the unprecedented vision of the intestinal microbiota given by large-scale quantitative metagenomics studies, such as the EU MetaHIT project, functional metagenomics tools allow the exploration of fine interactions between food constituents, microbiota and host, leading to the identification of signals and intimate mechanisms of crosstalk, especially between bacteria and human cells. Cloning of large genome fragments, either from complex intestinal communities or from selected bacteria, allows the screening of these biological resources for bioactivity towards complex plant polymers or functional food such as prebiotics. This permitted identification of novel carbohydrate-active enzyme families involved in dietary fibre and host glycan breakdown, and highlighted unsuspected bacterial players at the top of the intestinal microbial food chain. Similarly, exposure of fractions from genomic and metagenomic clones onto human cells engineered with reporter systems to track modulation of immune response, cell proliferation or cell metabolism has allowed the identification of bioactive clones modulating key cell signalling pathways or the induction of specific genes. This opens the possibility to decipher mechanisms by which commensal bacteria or candidate probiotics can modulate the activity of cells in the intestinal epithelium or even in distal organs such as the liver, adipose tissue or the brain. Hence, in spite of our inability to culture many of the dominant microbes of the human intestine, functional metagenomics open a new window for the exploration of food-microbe-host crosstalk.

  17. A computational approach for deciphering the organization of glycosaminoglycans.

    Science.gov (United States)

    Spencer, Jean L; Bernanke, Joel A; Buczek-Thomas, Jo Ann; Nugent, Matthew A

    2010-02-23

    glycosaminoglycans. These tools will provide a means to consider high-level chain organization in deciphering the structure-function relationships of polysaccharides in biology.

  18. Deciphering the porcine intestinal microRNA transcriptome

    Directory of Open Access Journals (Sweden)

    Keller Andreas

    2010-04-01

    Full Text Available Abstract Background While more than 700 microRNAs (miRNAs are known in human, a comparably low number has been identified in swine. Because of the close phylogenetic distance to humans, pigs serve as a suitable model for studying e.g. intestinal development or disease. Recent studies indicate that miRNAs are key regulators of intestinal development and their aberrant expression leads to intestinal malignancy. Results Here, we present the identification of hundreds of apparently novel miRNAs in the porcine intestine. MiRNAs were first identified by means of deep sequencing followed by miRNA precursor prediction using the miRDeep algorithm as well as searching for conserved miRNAs. Second, the porcine miRNAome along the entire intestine (duodenum, proximal and distal jejunum, ileum, ascending and transverse colon was unraveled using customized miRNA microarrays based on the identified sequences as well as known porcine and human ones. In total, the expression of 332 intestinal miRNAs was discovered, of which 201 represented assumed novel porcine miRNAs. The identified hairpin forming precursors were in part organized in genomic clusters, and most of the precursors were located on chromosomes 3 and 1, respectively. Hierarchical clustering of the expression data revealed subsets of miRNAs that are specific to distinct parts of the intestine pointing to their impact on cellular signaling networks. Conclusions In this study, we have applied a straight forward approach to decipher the porcine intestinal miRNAome for the first time in mammals using a piglet model. The high number of identified novel miRNAs in the porcine intestine points out their crucial role in intestinal function as shown by pathway analysis. On the other hand, the reported miRNAs may share orthologs in other mammals such as human still to be discovered.

  19. Compact Extra Dimensions in Quantum Mechanics

    CERN Document Server

    Deutschmann, Nicolas

    2016-01-01

    Extra-dimensions are a common topic in popular descriptions of theoretical physics with which undergraduate student most often have no contact in physics courses. This paper shows how students could be introduced to this topic by presenting an approach to two basic consequences of the presence of compact extra-dimensions based on undergraduate-level physics. The insensibility of low-energy physics to compact extra dimensions is illustrated in the context of non-relativistic quantum mechanics and the prediction of Kaluza-Klein excitations of particles is discussed in the framework of relativistic wave-equations. An exercise that could be used as a follow-up to the "particle in a box" is proposed.

  20. Extra-dimensional models on the lattice

    CERN Document Server

    Knechtli, Francesco

    2016-01-01

    In this review we summarize the ongoing effort to study extra-dimensional gauge theories with lattice simulations. In these models the Higgs field is identified with extra-dimensional components of the gauge field. The Higgs potential is generated by quantum corrections and is protected from divergencies by the higher dimensional gauge symmetry. Dimensional reduction to four dimensions can occur through compactification or localization. Gauge-Higgs unification models are often studied using perturbation theory. Numerical lattice simulations are used to go beyond these perturbative expectations and to include non-perturbative effects. We describe the known perturbative predictions and their fate in the strongly-coupled regime for various extra-dimensional models.

  1. Extra-pulmonary manifestations of sarcoidosis

    Energy Technology Data Exchange (ETDEWEB)

    Vardhanabhuti, V. [Radiology Department, Derriford Hospital, Plymouth (United Kingdom); Venkatanarasimha, N. [St Michael' s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8 (Canada); Bhatnagar, G.; Maviki, M.; Iyengar, S.; Adams, W.M. [Radiology Department, Derriford Hospital, Plymouth (United Kingdom); Suresh, P., E-mail: sureshpriya2000@yahoo.com [Radiology Department, Derriford Hospital, Plymouth (United Kingdom)

    2012-03-15

    Although, the diagnosis and evaluation of sarcoidosis has traditionally remained confined to the chest, its multi-system nature has been widely recognized. Radiological features of pulmonary sarcoidosis are well known but extra-pulmonary manifestations can produce a plethora of non-specific imaging findings that can affect subcutaneous tissue, and the neurological, cardiac, gastrointestinal, urological, liver, spleen, and skeletal systems. In the literature, there are various case reports and specific system reviews but there are few reviews that encompass all the extra-pulmonary manifestations. In this paper, we comprehensively review the imaging features of extra-pulmonary sarcoidosis with characteristic features as well as atypical presentations. In addition, we discuss the emerging role of nuclear medicine in sarcoidosis.

  2. Mediation of supersymmetry breaking in extra dimensions

    CERN Document Server

    Scrucca, C A

    2004-01-01

    I review the mechanisms of supersymmetry breaking mediation that occur in sequestered models, where the visible and the hidden sectors are separated by an extra dimension and communicate only via gravitational interactions. By locality, soft breaking terms are forbidden at the classical level and reliably computable within an effective field theory approach at the quantum level. I present a self-contained discussion of these radiative gravitational effects and the resulting pattern of soft masses, and give an overview of realistic model building based on this set-up. I consider both flat and warped extra dimensions, as well as the possibility that there be localized kinetic terms for the gravitational fields.

  3. Electromagnetism from extra space multi connectivity

    Energy Technology Data Exchange (ETDEWEB)

    Gauthier, C. [Moncton Univ., Moncton (France). Dept. de Mathematiques et de Statistique

    2001-09-01

    In a unified field theory of the Kaluza-Klein type, it is used a multi connected extra space to interpret geometrically the quantum properties of physics. This paper presents a pure geometric interpretation of electromagnetism. The electric change of a body is identified with its cross-section for interaction of twisted waves due to the extra space multi connectivity. A by-product of this interpretation is an expression for the permittivity of free space as an integral of the flux of these waves over their frequencies.

  4. Signatures of extra dimensional sterile neutrinos

    Directory of Open Access Journals (Sweden)

    Werner Rodejohann

    2014-10-01

    Full Text Available We study a large extra dimension model with active and sterile Dirac neutrinos. The sterile neutrino masses stem from compactification of an extra dimension with radius R and are chosen to have masses around eV or keV, in order to explain short-baseline anomalies or act as warm dark matter candidates. We study the effect of the sterile neutrino Kaluza–Klein tower in short-baseline oscillation experiments and in the beta spectrum as measurable by KATRIN-like experiments.

  5. Signatures of extra dimensional sterile neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    Rodejohann, Werner, E-mail: werner.rodejohann@mpi-hd.mpg.de; Zhang, He, E-mail: he.zhang@mpi-hd.mpg.de

    2014-10-07

    We study a large extra dimension model with active and sterile Dirac neutrinos. The sterile neutrino masses stem from compactification of an extra dimension with radius R and are chosen to have masses around eV or keV, in order to explain short-baseline anomalies or act as warm dark matter candidates. We study the effect of the sterile neutrino Kaluza–Klein tower in short-baseline oscillation experiments and in the beta spectrum as measurable by KATRIN-like experiments.

  6. The Higgs Mechanism from an extra dimension

    CERN Document Server

    A., Yu

    2016-01-01

    The standard $SU(2) \\times U(1)$ fields are considered in 4D plus one extra compact dimension. As a result two basic effects are obtained. First, four Goldstone-like scalars are produced, three of them are used to create longitudinal modes of the $W,Z$ fields, while the fourth becomes the Higgs-like scalar. Second, $W$ and $Z$ get their masses from the extra compact dimension with the standard pattern of symmetry violation. The resulting theory has the same fields as in the standard model, but without the Higgs vacuum average. The properties of the new Higgs scalar and its interaction with fermions are briefly discussed.

  7. Phenomenology of symmetry breaking from extra dimensions

    CERN Document Server

    Alfaro, J; Gavela-Legazpi, Maria Belen; Rigolin, S; Salvatori, M

    2007-01-01

    Motivated by the electroweak hierarchy problem, we study the symmetry breaking pattern induced by a background magnetic flux living on extra dimensions, with the four-dimensional scalar fields being gauge boson components in full space. For SU(N) and two compact, toroidal, extra dimensions, we determine analytically the possible field configurations of stable vacua and their symmetries. From the four-dimensional point of view, the system responds dynamically to the magnetic background by an infinite chain of vacuum expectation values so as to reach a stable vacuum. The equivalence between flux compactification and constant boundary conditions - either Scherk-Schwarz or twisted - is established.

  8. Deciphering Pressure-Temperature path of the Stak eclogites (Pakistan)

    Science.gov (United States)

    Lanari, Pierre; Vidal, Olivier; Engi, Martin

    2013-04-01

    in China and the Western Gneiss province in Norway (Lanari et al., 2013). Lanari, P., Riel, N., Guillot, S., Vidal, O., Schwartz, S., Pêcher, A., Hattori, K. (2013).Deciphering High-Pressure metamorphism in collisional context using microprobe-mapping methods: application to the Stak eclogitic massif (NW Himalaya). In Press, Geology, doi:10.1130/G33523.1.

  9. Extra-1 acupressure for children undergoing anesthesia.

    Science.gov (United States)

    Wang, Shu-Ming; Escalera, Sandra; Lin, Eric C; Maranets, Inna; Kain, Zeev N

    2008-09-01

    Acupuncture and related techniques have been used as adjuncts for perioperative anesthesia management. We examined whether acupressure in the Extra-1 (Yin-Tang) point would result in decreased preprocedural anxiety and reduced intraprocedural propofol requirements in a group of children undergoing endoscopic procedures. Fifty-two children were randomized to receive acupressure bead intervention either at the Extra-1 acupuncture point or at a sham point. A Bispectral Index (BIS) monitor was applied to all children before the onset of the intervention. Anxiety was assessed at baseline and before entrance to the operating room. Anesthetic techniques were standardized and maintained with IV propofol infusion titrated to keep BIS values of 40-60. We found that after the intervention, children in the Extra-1 group experienced reduced anxiety whereas children in the sham group experienced increased anxiety (-9% [-3 to -15] vs 2% [-6 to 7.4], P = 0.012). In contrast, no significant changes in BIS values were observed in the preprocedural waiting period between groups (P = ns). We also found that total intraprocedural propofol requirements did not differ between the two study groups (214 +/- 76 microg x kg(-1) x min(-1) vs 229 +/- 95 microg x kg(-1) x min(-1), P = 0.52). We conclude that acupressure bead intervention at Extra-1 acupoint reduces preprocedural anxiety in children undergoing endoscopic procedures. This intervention, however, has no impact on BIS values or intraprocedural propofol requirements.

  10. Gauge coupling unification with extra Higgs doublets

    Energy Technology Data Exchange (ETDEWEB)

    Harada, Junpei [Research Center for Higher Education, Health Sciences University of Hokkaido (Japan)

    2016-06-15

    Gauge coupling unification is studied within the framework where there are extra Higgs doublets and E{sub 6} exotic fields. Supersymmetric models and nonsupersymmetric models are investigated, and a catalog of models with gauge coupling unification is presented. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  11. Precision constraints on extra fermion generations.

    Science.gov (United States)

    Erler, Jens; Langacker, Paul

    2010-07-16

    There has been recent renewed interest in the possibility of additional fermion generations. At the same time there have been significant changes in the relevant electroweak precision constraints, in particular, in the interpretation of several of the low energy experiments. We summarize the various motivations for extra families and analyze them in view of the latest electroweak precision data.

  12. Probing Extra Dimensions with Neutrino Oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Machado, P.A.N. [Instituto de Fisica, Universidade de Sao Paulo, C. P. 66.318, 05315-970 Sao Paulo (Brazil); Nunokawa, H. [Departamento de Fisica, Pontificia Universidade Catolica do Rio de Janeiro, C. P. 38071, 22452-970 Rio de Janeiro (Brazil); Zukanovich Funchal, R., E-mail: zukanov@fma.if.usp.br [Instituto de Fisica, Universidade de Sao Paulo, C. P. 66.318, 05315-970 Sao Paulo (Brazil)

    2011-08-15

    We consider a model where sterile neutrinos can propagate in a large compactified extra dimension (a) giving rise to Kaluza-Klein (KK) modes and the Standard Model left-handed neutrinos are confined to a 4-dimensional spacetime brane. The KK modes mix with the standard neutrinos modifying their oscillation pattern. We examine current experiments in this framework obtaining stringent limits on a.

  13. Extra-oral halitosis : an overview

    NARCIS (Netherlands)

    Tangerman, A.; Winkel, E. G.

    2010-01-01

    Halitosis can be subdivided into intra-oral and extra-oral halitosis, depending on the place where it originates. Most reports now agree that the most frequent sources of halitosis exist within the oral cavity and include bacterial reservoirs such as the dorsum of the tongue, saliva and periodontal

  14. Cystic lesions accompanying extra-axial tumours

    NARCIS (Netherlands)

    Lohle, PNM; Wurzer, HAL; Seelen, PJ; Kingma, LM; Go, KG

    1999-01-01

    We examined the mechanism of cyst formation in extra-axial tumours in the central nervous system (CNS). Cyst fluid, cerebrospinal fluid (CSF) and blood plasma were analysed in eight patients with nine peritumoral cysts: four with meningiomas, two with intracranial and two spinal intradural schwannom

  15. Extra dimensions and violations of Lorentz symmetry

    CERN Document Server

    Overduin, James M

    2016-01-01

    We use experimental limits on Lorentz violation to obtain new constraints on Kaluza-Klein-type theories in which the extra dimensions may be large but do not necessarily have units of length. The associated variation in fundamental quantities such as rest mass must occur slowly, on cosmological scales.

  16. The Night Of Hennessy Paradis Extra Cognac

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>The world-known Hennessy Paradis Extra Cognaclaunched its"dazzling night"on the evening of May 22 tolet guests enjoy to their hearts’content the fine wine andthe charming glamour of the diamond evening dress. A liquid,dating back to the 18th century,was called

  17. Tendinopathy of the long head of the biceps tendon: histopathologic analysis of the extra-articular biceps tendon and tenosynovium

    OpenAIRE

    Streit JJ; Shishani Y; Rodgers M; Gobezie R

    2015-01-01

    Jonathan J Streit,1 Yousef Shishani,1 Mark Rodgers,2 Reuben Gobezie1 1The Cleveland Shoulder Institute, 2Department of Pathology, University Hospitals of Cleveland, Cleveland, OH, USA Background: Bicipital tendinitis is a common cause of anterior shoulder pain, but there is no evidence that acute inflammation of the extra-articular long head of the biceps (LHB) tendon is the root cause of this condition. We evaluated the histologic findings of the extra-articular portion of the LHB tendon an...

  18. Light Stop, Heavy Higgs, and Heavy Gluino in Supersymmetric Standard Models with Extra Matters

    CERN Document Server

    Hisano, Junji; Kuwahara, Takumi

    2016-01-01

    We have explored the possibilities of scenarios with heavy gluinos and light stops in the supersymmetric (SUSY) standard models with extra vector-like multiplets. If we assume the hierarchical structure for soft masses of MSSM scalar fields and extra scalars, the light stop and the observed Higgs boson can be realized. While the stau is the lightest SUSY particle (LSP) in broad parameter space, we have found the neutralino LSP is realized in the case that the non-zero soft parameters for the MSSM Higgs doublets or the non-universal gaugino masses are assumed.

  19. Extra-galactic magnetic fields and the second knee in the cosmic-ray spectrum

    CERN Document Server

    Lemoine, M

    2004-01-01

    Recent work suggests that the cosmic ray spectrum may be dominated by Galactic sources up to ~10^{17.5} eV, and by an extra-Galactic component beyond, provided this latter cuts off below the transition energy. Here it is shown that this cut-off could be interpreted as a signature of extra-galactic magnetic fields with equivalent average strength B and coherence length l_c such that B\\sqrt{l_c}~2.10^{-10} G.Mpc^{1/2}, assuming l_c < r_L (Larmor radius at 10^{17} eV) and continuously emitting sources with density 10^{-5}/Mpc^3. The extra-Galactic flux is suppressed below 10^{17} eV as the diffusive propagation time from the source to the detector becomes larger than the age of the Universe.

  20. Gravity with extra dimensions and dark matter interpretation: A straightforward approach

    CERN Document Server

    Coimbra-Araujo, C H

    2013-01-01

    Any connection between dark matter and extra dimensions can be cognizably evinced from the associated effective energy-momentum tensor. In order to investigate and test such relationship, a higher dimensional spacetime endowed with a factorizable general metric is regarded to derive a general expression for the stress tensor -- from the Einstein-Hilbert action -- and to elicit the effective gravitational potential. A particular construction for the case of six dimensions is provided, and it is forthwith revealed that the missing mass phenomenon may be explained, irrespective of the dark matter existence. Moreover, the existence of extra dimensions in the universe accrues the possibility of a straightforward mechanism for such explanation. A configuration which density profile coincides with the Newtonian potential for spiral galaxies is constructed, from a 4-dimensional isotropic metric plus extra-dimensional components. A Miyamoto-Nagai \\emph{ansatz} is used to solve Einstein equations. The stable rotation c...

  1. Codes of conduct: An extra suave instrument of EU governance?

    DEFF Research Database (Denmark)

    Borras, Susana

    establishes a specific set of voluntary norms and principles that shall guide the recruiting process of researchers by European research organizations (universities, public research organizations and firms) in the 33 countries of the single market minded initiative of the European Research Area. A series...... of hypothesis are formulated on the basis of theoretically-inspired assumptions. Quantitative and qualitative data shall be provided in the near future, however preliminary information regarding the implementation progress of the CCRR shows that there are quite diversified responses at national level. The extra......In recent years the European Union has been introducing new governance instruments. This paper examines the use of one such new types of governance instruments, namely, codes of conduct. The paper addresses the following two research questions, namely, under what conditions are codes of conduct...

  2. Can extra dimensional effects allow wormholes without exotic matter?

    Energy Technology Data Exchange (ETDEWEB)

    Kar, Sayan, E-mail: sayan@iitkgp.ac.in [Department of Physics and Center for Theoretical Studies, Indian Institute of Technology, Kharagpur, 721 302 (India); Lahiri, Sayantani, E-mail: sayantani.lahiri@gmail.com [Institute for Physics, University Oldenburg, D-26111 Oldenburg (Germany); ZARM, University of Bremen, Am Fallturm, 28359 Bremen (Germany); SenGupta, Soumitra, E-mail: tpssg@iacs.res.in [Department of Theoretical Physics, Indian Association for the Cultivation of Science, 2A and 2B Raja S.C. Mallick Road, Jadavpur, Kolkata 700 032 (India)

    2015-11-12

    We explore the existence of Lorentzian wormholes in the context of an effective on-brane, scalar-tensor theory of gravity. In such theories, the timelike convergence condition, which is always violated for wormholes, has contributions, via the field equations, from on-brane matter as well as from an effective geometric stress energy generated by a bulk-induced radion field. It is shown that, for a class of wormholes, the required on-brane matter, as seen by an on-brane observer in the Jordan frame, is not exotic and does not violate the Weak Energy Condition. The presence of the effective geometric stress energy in addition to on-brane matter is largely responsible for creating this intriguing possibility. Thus, if such wormholes are ever found to exist in the Universe, they would clearly provide pointers towards the existence of a warped extra dimension as proposed in the two-brane model of Randall and Sundrum.

  3. Construction Process Control of Large Extra Caissons

    Institute of Scientific and Technical Information of China (English)

    HU Shaowei; WANG Hongxia; FAN Jiansheng

    2005-01-01

    The complexity of geotechnical engineering and variability in construction circumstances of large extra caissons make the problem of maintaining appropriate sink attitude quite difficult, especially in keeping sink uniformity and achieving the expected final sink depth. A new construction control method is presented using (H∞) theory, considering uncertainties in the mechanics model and external noise in the construction site parameters. The design method of an (H∞) controller has consequently been obtained for large extra caissons. Control results using only constructor experiences are compared with simulation results using the (H∞) controller for a practical engineering situation, which indicates that the (H∞) controller is successful in maintaining sink uniformity, avoiding sink as well as in achieving the expected final sink depth.

  4. Brane modeling in warped extra-dimension

    CERN Document Server

    Ahmed, Aqeel

    2012-01-01

    Five-dimensional scenarios with infinitesimally thin branes replaced by appropriate configurations of a scalar field were considered. A possibility of periodic extra dimension was discussed in the presence on non-minimal scalar-gravity coupling and a generalized Gibbons-Kallosh-Linde sum rule was found. In order to avoid constraints imposed by periodicity, a non-compact spacial extra dimension was introduced. A five dimensional model with warped geometry and two thin branes mimicked by a scalar profile was constructed and discussed. In the thin brane limit the model corresponds to a set-up with two positive-tension branes. The presence of two branes allows to address the issue of the hierarchy problem which could be solved by the standard warping of the four dimensional metric. Stability of the background solution was discussed and verified in the presence of the most general perturbations of the metric and the scalar field.

  5. Indirect Collider Signals for Extra Dimensions

    CERN Document Server

    Hewett, J L

    1999-01-01

    A recent suggestion that quantum gravity may become strong near the weak scale has several testable consequences. In addition to probing for the new large (submillimeter) extra dimensions associated with these theories via gravitational experiments, one could search for the Kaluza Klein towers of massive gravitons which are predicted in these models and which can interact with the fields of the Standard Model. Here we examine the indirect effects of these massive gravitons being exchanged in fermion pair production in \\epem\\ annihilation and Drell-Yan production at hadron colliders. In the latter case, we examine a novel feature of this theory, which is the contribution of gluon gluon initiated processes to lepton pair production. We find that these processes provide strong bounds, up to several TeV, on the string scale which are essentially independent of the number of extra dimensions. In addition, we analyze the angular distributions for fermion pair production with spin-2 graviton exchanges and demonstrat...

  6. Extra-dimensional confinement of quantum particles

    CERN Document Server

    Hedin, Eric R

    2016-01-01

    A basic theoretical framework is developed in which elementary particles have a component of their wave function extending into higher spatial dimensions. This model postulates an extension of the Schrodinger equation to include a 4th and 5th spatial component. A higher-dimensional simple harmonic oscillator confining potential localizes particles into 3-d space, characterizing the brane tension which confines Standard Model particles to the sub-manifold. Quantum effects allow a non-zero probability for a particle's evanescent existence in the higher dimensions, and suggest an experimental test for the validity of this model via particles being temporarily excited into the first excited state of the extra-dimensional potential well, in which their probability of existing in 3-d space transiently drops to zero. Several consistency checks of the outcomes of this extra-dimensional model are included in this paper. Among the outcomes of this model are: a match with the quantum phenomenon of zitterbewegung; the pr...

  7. Celulitis por cuerpo extraño

    Directory of Open Access Journals (Sweden)

    Miguel B. Carrasco Guzmán

    2016-01-01

    Full Text Available Las infecciones de la piel y el tejido celular subcutáneo surgen como un grupo importante de afecciones con una alta morbilidad en edades pediátricas, generalmente relacionada con traumatismo y cuerpos extraños. Se presenta el caso de una escolar femenina de 6 años de edad, con síntomas y signos clínicos que sugieren celulitis en el muslo derecho,  por su evolución tórpida se le realizó el estudio ultrasonográfico que confirmó el diagnóstico etiológico de una celulitis secundaria a un traumatismo, provocada por la introducción de un gran cuerpo extraño, que pasó inadvertido para a familia de la menor.

  8. Neutrino anomalies and large extra dimensions

    CERN Document Server

    Dighe, A S; Dighe, Amol S.; Joshipura, Anjan S.

    2001-01-01

    Theories with large extra dimensions can generate small neutrino masses when the standard model neutrinos are coupled to singlet fermions propagating in higher dimensions. The couplings can also generate mass splittings and mixings among the flavour neutrinos in the brane. We systematically study the minimal scenario involving only one singlet bulk fermion coupling weakly to the flavour neutrinos. We explore the neutrino mass structures in the brane that can potentially account for the atmospheric, solar and LSND anomalies simultaneously in a natural way. We demonstrate that in the absence of a priori mixings among the SM neutrinos, it is not possible to reconcile all these anomalies. The presence of some structure in the mass matrix of the SM neutrinos can solve this problem. This is exemplified by the Zee model, which when embedded in extra dimensions in a minimal way can account for all the neutrino anomalies.

  9. Origin of extra chromosome in Patau syndrome.

    Science.gov (United States)

    Ishikiriyama, S; Niikawa, N

    1984-01-01

    Five live-born infants with Patau syndrome were studied for the nondisjunctional origin of the extra chromosome. Transmission modes of chromosomes 13 from parents to a child were determined using both QFQ- and RFA-heteromorphisms as markers, and the origin was ascertained in all of the patients. The extra chromosome had originated in nondisjunction at the maternal first meiotic division in two patients, at the maternal second meiosis in other two, and at the paternal first meiosis in the remaining one. Summarizing the results of the present study, together with those of the previous studies on a liveborn and abortuses with trisomy 13, nondisjunction at the maternal and the paternal meiosis occurred in this trisomy in the ratio of 14:3. This ratio is not statistically different from that inferred from the previous studies for Down syndrome. These findings suggest that there may be a fundamental mechanism common to the occurrence of nondisjunction in the acrocentric trisomies.

  10. Precision Constraints on Extra Fermion Generations

    CERN Document Server

    Erler, Jens

    2010-01-01

    In the recent past there has been renewed interest in the possibility of additional fermion generations. At the same time there have been significant changes in the relevant electroweak (EW) precision constraints, in particular in the interpretation of several of the low energy experiments. We summarize the various motivations for the increased activity regarding extra families and analyze them in view of the latest EW precision data.

  11. Extra gauge symmetries in BHT gravity

    CERN Document Server

    Blagojević, M

    2011-01-01

    We study the canonical structure of the Bergshoeff-Hohm-Townsend massive gravity, linearized around a maximally symmetric background. At the critical point in the space of parameters, defined by $\\Lambda_0/m^2=-1$, we discover an extra gauge symmetry, which reflects the existence of the partially massless mode. The number of the Lagrangian degrees of freedom is found to be 1. We show that the canonical structure of the theory at the critical point is unstable under linearization.

  12. Extra gauge symmetries in BHT gravity

    Science.gov (United States)

    Blagojević, M.; Cvetković, B.

    2011-03-01

    We study the canonical structure of the Bergshoeff-Hohm-Townsend massive gravity, linearized around a maximally symmetric background. At the critical point in the space of parameters, defined by Λ 0/ m 2 = -1, we discover an extra gauge symmetry, which reflects the existence of the partially massless mode. The number of the Lagrangian degrees of freedom is found to be 1. We show that the canonical structure of the theory at the critical point is unstable under linearization.

  13. Quantum simulation of an extra dimension.

    Science.gov (United States)

    Boada, O; Celi, A; Latorre, J I; Lewenstein, M

    2012-03-30

    We present a general strategy to simulate a D+1-dimensional quantum system using a D-dimensional one. We analyze in detail a feasible implementation of our scheme using optical lattice technology. The simplest nontrivial realization of a fourth dimension corresponds to the creation of a bi-volume geometry. We also propose single- and many-particle experimental signatures to detect the effects of the extra dimension.

  14. Dimensional reduction without continuous extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Chamseddine, Ali H. [American University of Beirut, Physics Department, Beirut, Lebanon and I.H.E.S. F-91440 Bures-sur-Yvette (France); Froehlich, J.; Schubnel, B. [ETHZ, Mathematics and Physics Departments, Zuerich (Switzerland); Wyler, D. [Institute of Theoretical Physics, University of Zuerich (Switzerland)

    2013-01-15

    We describe a novel approach to dimensional reduction in classical field theory. Inspired by ideas from noncommutative geometry, we introduce extended algebras of differential forms over space-time, generalized exterior derivatives, and generalized connections associated with the 'geometry' of space-times with discrete extra dimensions. We apply our formalism to theories of gauge- and gravitational fields and find natural geometrical origins for an axion- and a dilaton field, as well as a Higgs field.

  15. Collider Implications Of Extra Dimensions At Lhc

    CERN Document Server

    Reema

    2005-01-01

    Scope and method of study. The intent of this research is to consider multiple TeV-1-size extra compact dimensions in an asymmetric string compactification scenario in which the SM gauge bosons can propagate into the TeV-1-size extra dimensions while the SM fermions are confined to the usual SM D3-brane. The contributions that the KK excitations of the gluons, g*'s, make to the multijet cross sections in proton- proton collisions at the LHC energy are calculated. Fortran was used to do the calculations. Findings and conclusions. At very high pT, the dijet signal will either be enhanced significantly due to virtual g* exchanges or place a lower bound on the compactification scale of about 8 TeV. It is found that the dijet signal is very sensitive to three parameters—the compactification scale, the string scale, and the number of extra dimensions. Thus, although the dijet signal is much more sensitive to KK effects, the dijet signal alone does not provide sufficient information to deduce the number of...

  16. MR findings of extra abdominal fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hee Jin; Lee, Sung Moon; Rhee, Chang Soo; Sohn, Chul Ho; Lee, Hee Jung; Kim, Jung Sik; Kim, Hong [Dongsan Medical Center, Keimyung Univ. College of Medicine, Taegu (Korea, Republic of); Seo, Kyung Jin [Suh Joo MRI center, Seoul (Korea, Republic of); Jo, Kil Ho [Youngnam Univ. College of Medicine, Kyongsan (Korea, Republic of)

    1999-12-01

    To evaluate the MR findings of extra-abdominal fibromatosis and the role of MRI in primary diagnosis Fifteen cases in of histologically proven extra-abdominal fibromatosis in 13 patients were retrospectively reviewed. T1-weighted and T2-weighted images were obtained in axial, coronal and sagittal planes. Gd-enhancement was performed in 14 cases, and dynamic enhancement studies in two. All lesions were evaluated for mass shape and margin definition. Among the 15 cases, tumors of the buttock accounted for five, and tumor of the thigh for two. in eight cases tumors were intermuscular and in six cases were intramuscular. In ten cases (67%) the mass extended along the long axis of the body and in 14 of 15 cases (93%) focal infiltration of adjacent structures was visible. The signal intensity of the lesion was in all cases inhomogeneous on both T1 and T2 weighted images. As seen on Gd-DTPA enhanced scans, the masses were inhomogeneously enhanced. In all cases MRI revealed star-shaped linear strands or a band-like low signal area in the mass. These features were not enhanced and were arranged along the long axis of the mass. MR findings of extra-abdominal fibromatosis were relatively characteristic and helpful for primary diagnosis of the condition.

  17. Who Does Extra-Credit Work in Introductory Science Courses?

    Science.gov (United States)

    Moore, Randy

    2005-01-01

    On the first day of classes, 81% of students in an introductory biology course claimed that they would submit extra-credit work if given the opportunity. When given two chances for extra-credit work, fewer than one-fourth of students submitted one or both assignments. Students who submitted extra-credit work were more likely to attend class,…

  18. Extra-adrenal Pheochromocytoma in an Adolescent

    Directory of Open Access Journals (Sweden)

    Abdullah, Ibrahim

    2011-05-01

    Full Text Available A 17-year-old male with symptoms of headache and diaphoresis presented to the emergency department. He had eight months of noted hypertension attributed to medications. On arrival his blood pressure was 229/117mmHg, and he was ill-appearing. His blood pressure was managed aggressively, and he was diagnosed with extra-adrenal pheochromocytoma by computed tomography. He eventually underwent resection of the mass. Children with severe, symptomatic hypertension should be evaluated for pheochromocytoma. Although rare, it is curable. Failure to diagnose carries a high risk of morbidity and mortality. [West J Emerg Med. 2011;12(2:258-261.

  19. Aneurisma micotico de origem extra-vascular

    Directory of Open Access Journals (Sweden)

    Nelson Pires Ferreira

    1976-12-01

    Full Text Available É relatado o caso de uma paciente com três anos de idade portadora de oftalmoplegia completa unilateral e aneurisma da artéria carótida interna, em sua porção intra-cavernosa. A etiologia infecciosa extra-vascular, na vigência de tromboflebite de seio cavernoso, foi considerada. As informações da literatura são discutidas, sendo comentada a infrequência da patologia. A indicação de ligadura da artéria carótida interna, no tratamento desses aneurismas, merece ulterior comprovação.

  20. Radio communications with extra-terrestrial civilizations

    Science.gov (United States)

    Kotelnikov, V. A.

    1974-01-01

    Communications between civilizations within our galaxy at the present level of radio engineering is possible, although civilizations must begin to search for each other to achieve this. If an extra-terrestrial civilization possessing a technology at our level wishes to make itself known and will transmit special radio signals to do this, then it can be picked up by us at a distance of several hundreds of light years using already existing radio telescopes and specially built radio receivers. If it wishes, this civilization can also send us information without awaiting our answer.

  1. Extra-mammary findings in breast MRI

    Energy Technology Data Exchange (ETDEWEB)

    Rinaldi, Pierluigi; Costantini, M.; Belli, P.; Giuliani, M.; Bufi, E.; Fubelli, R.; Distefano, D.; Romani, M.; Bonomo, L. [Catholic University - Policlinic A. Gemelli, Department of Bio-Imaging and Radiological Sciences, Rome (Italy)

    2011-11-15

    Incidental extra-mammary findings in breast Magnetic Resonance Imaging (MRI) may be benign in nature, but may also represent a metastasis or another important lesion. We aimed to analyse the prevalence and clinical relevance of these unexpected findings. A retrospective review of 1535 breast MRIs was conducted. Only axial sequences were reassessed. Confirmation examinations were obtained in all cases. 285 patients had a confirmed incidental finding, which were located in the liver (51.9%), lung (11.2%), bone (7%), mediastinal lymph nodes (4.2%) or consisted of pleural/pericardial effusion (15.4%). 20.4% of incidental findings were confirmed to be malignant. Positive predictive value for MRI to detect a metastatic lesion was high if located within the bone (89%), lymph nodes (83%) and lung (59%), while it was low if located within the liver (9%) or if it consisted of pleural/pericardial effusion (6%). The axial enhanced sequence showed superior sensitivity to unenhanced images in detecting metastatic lesions, especially if only smaller ({<=}10 mm.) lesions were considered. The prevalence of metastatic incidental extra-mammary findings is not negligible. Particular attention should be to incidental findings located within the lung, bone and mediastinal lymph nodes. (orig.)

  2. Neutrino Mass Models in Extra Dimensions

    CERN Document Server

    Ng, J N

    2003-01-01

    Neutrinos play a crucial role in many areas of physics from very short distances to astrophysics and cosmology. It is a long held believe that they are good probes of physics at the GUT scale. Recent developments have made it clear that they can also be of fundamental importance for the physics of extra dimensions if these exist. Here we pedagogically review the construction of neutrino mass models in extra dimensions within the brane world scenarios. These models are usually nontrivial generalizations of their four dimensional counterparts. We describe the theoretical tools that have been forged and the new perpectives gained in this rapidly developing area. In particular we discuss the issues involve in building models without the use of right-handed singlets. It is very difficult to directly test the origin of neutrino masses in different models be it in four or more dimensions. We point out that different models give very different indirect signatures in the TeV region and in precision measurements.

  3. Neptune migration model with one extra planet

    CERN Document Server

    Yeh, Lun-Wen; 10.1016/j.icarus.2009.06.008

    2009-01-01

    We explore conventional Neptune migration model with one additional planet of mass at 0.1-2.0 Me. This planet inhabited in the 3:2 mean motion resonance with Neptune during planet migration epoch, and then escaped from the Kuiper belt when Jovian planets parked near the present orbits. Adding this extra planet and assuming the primordial disk truncated at about 45 AU in the conventional Neptune migration model, it is able to explain the complex structure of the observed Kuiper belt better than the usual Neptune migration model did in several respects. However, numerical experiments imply that this model is a low-probability event. In addition to the low probability, two features produced by this model may be inconsistent with the observations. They are small number of low-inclination particles in the classical belt, and the production of a remnant population with near-circular and low-inclination orbit within a = 50-52 AU. According to our present study, including one extra planet in the conventional Neptune ...

  4. Exploring extra dimensions with scalar waves

    CERN Document Server

    Jones-Smith, Katherine; Verostek, Michael

    2016-01-01

    This paper provides a pedagogical introduction to the physics of extra dimensions focussing on the ADD, Randall-Sundrum and DGP models. In each of these models, the familiar particles and fields of the standard model are assumed to be confined to a four dimensional space-time called the brane; the brane is a slice through a higher dimensional space-time called the bulk. The geometry of the ADD, Randall-Sundrum and DGP space-times is described and the relation between Randall-Sundrum and Anti-de-Sitter space-time is explained. The necessary differential geometry background is introduced in an appendix that presumes no greater mathematical preparation than multivariable calculus. The ordinary wave equation and the Klein-Gordon equation are briefly reviewed followed by an analysis of the propagation of scalar waves in the bulk in all three extra-dimensional models. We also calculate the scalar field produced by a static point source located on the brane for all three models. For the ADD and Randall-Sundrum model...

  5. Extra-Galactic Diffuse Interstellar Bands

    Science.gov (United States)

    Cox, N.; Ehrenfreund, Pascale; Kaper, Lex; Spaans, Marco; Foing, Bernard

    Diffuse Interstellar Bands (DIBs) have been observed ubiquitously along many sight-lines probing the interstellar medium of the Milky Way. Despite extensive efforts, their carrier(s) have not yet been identified, although they are very likely of a carbonaceous nature and reside in the gas phase. Possible candidates include, but are not limited to, polycyclic aromatic hydro- carbons (PAHs), fullerenes and carbon chains. To advance our understanding of DIB behaviour and thus DIB carrier properties we need to study environments inherently different from those observed in the Milky Way. Only recent advances in instrumentation and telescope capabilities are providing us with new exciting possibilities for extra-galactic DIB research. We present here a selection of our recent observational results for (extra)-galactic DIBs in the Local Group and beyond. In particular, DIBs in the Magellanic Clouds and in the spiral galaxy NGC1448. These first results show surprising similarities between certain DIB profiles as well as differences in DIB behaviour. Understanding diffuse cloud chemistry, in particular with respect to complex (carbonaceous) molecules, is crucial to any DIB carrier identification. In this respect, external galaxies offer a unique window as they exhibit local interstellar conditions (such as metallicity, UV-field and gas-to-dust ratio) very different from those observed in the Milky Way. We discuss briefly the effect of metallicity and the gas-to-dust ratio on the physi-chemical properties of diffuse clouds and the subsequent effects on the PAH charge state distribution and the DIB carriers.

  6. [Extra-articular manifestations of seronegative spondylarthritis].

    Science.gov (United States)

    Cammelli, Daniele

    2006-05-01

    Seronegative spondylarthritis are frequently characterised by extra-articular manifestations. They are frequently in recurrent uveitis. Between the cutaneous manifestations should be mentioned erythema nodosum, typical of inflammatory bowel diseases, and keratoderma blenorrhagicum, in the Reiter's syndrome. Cardiac complications in ankylosing spondylitis (AS) include aortic valvular regurgitation and arrhythmia and, more rarely, mitral valvulopathy, cardiomyopathy and pericarditis. Pulmonary involvement in AS includes ventilatory restrictive syndrome and fibro-bullous disease of the apex. Vertebral osteoporosis is a very important extra-articular manifestation because of the possibility of spontaneous fractures of the vertebrae. Central neurological manifestations include medullary compression from cervical sub-luxation while the most important peripheral involvements are lumbar stenosis and the cauda equina syndrome. Type AA amyloidosis is a rare late complication of the AS, possible cause of death especially in patients with aggressive disease. Kidney complications can be observed as consequences of prolonged anti-inflammatory therapy, but the most frequent renal complications are amyloidosis and mesangial IgA segmental and focal glomerulonephritis.

  7. Gauge symmetries emerging from extra dimensions

    Science.gov (United States)

    Chkareuli, J. L.; Kepuladze, Z.

    2016-09-01

    We argue that extra dimensions with a properly chosen compactification scheme could be a natural source for emergent gauge symmetries. Actually, some proposed vector field potential terms or polynomial vector field constraints introduced in five-dimensional Abelian and non-Abelian gauge theory are shown to smoothly lead to spontaneous violation of an underlying 5D spacetime symmetry and generate pseudo-Goldstone vector modes as conventional 4D gauge boson candidates. As a special signature, there appear, apart from conventional gauge couplings, some properly suppressed direct multiphoton (multiboson, in general) interactions in emergent QED and Yang-Mills theories whose observation could shed light on their high-dimensional nature. Moreover, in emergent Yang-Mills theories an internal symmetry G also occurs spontaneously broken to its diagonal subgroups once 5D Lorentz violation happens. This breaking originates from the extra vector field components playing a role of some adjoint scalar field multiplet in the 4D spacetime. So, one naturally has the Higgs effect without a specially introduced scalar field multiplet. Remarkably, when being applied to grand unified theories (GUTs) this results in a fact that the emergent GUTs generically appear broken down to the Standard Model just at the 5D Lorentz violation scale M .

  8. MAGNETIC AND PALAEOMAGNETIC STUDIES AS AN AID IN DECIPHERING GROUNDWATER FLOW: A CASE STUDY FROM DECCAN TRAPS

    Directory of Open Access Journals (Sweden)

    Poornachandra Rao G.V.S.

    2009-07-01

    Full Text Available This paper reports the utility of palaeomagnetic investigations first time in the ground water studies. The magnetic anomalies along with palaeomagnetic studies are used to locate barriers obstructing groundwater flow in a basaltic terrain. Magnetic anomalies in an area of around 4 sq. km in the university campus, Nanded, Maharashtra, India brought out two distinct anomaly closures that can be attributed to bodies with different directions of magnetizations. Palaeomagnetic investigations reveal that the basalts are almost uniformly magnetized, asserting that the anomalies come form the subsurface and the anomalous sources are attributed to weathering of basal basaltic flows. The difference between the measured palaeomagnetic directions of the surface rocks and the observed magnetic anomalies, in corroboration with local geomorphologic conditions and thenature of the basaltic flows in thin basaltic terrains suggest that subsurface weathering plays a major role in the ground water movement. This paper presents a novel idea on the utilization of the palaeomagnetic studies coupled with ground magnetic anomalies in deciphering groundwater flow.

  9. Celulitis por cuerpo extraño

    OpenAIRE

    2016-01-01

    Las infecciones de la piel y el tejido celular subcutáneo surgen como un grupo importante de afecciones con una alta morbilidad en edades pediátricas, generalmente relacionada con traumatismo y cuerpos extraños. Se presenta el caso de una escolar femenina de 6 años de edad, con síntomas y signos clínicos que sugieren celulitis en el muslo derecho,  por su evolución tórpida se le realizó el estudio ultrasonográfico que confirmó el diagnóstico etiológico de una celulitis secundaria a un traumat...

  10. Phenomenology of symmetry breaking from extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Alfaro, Jorge [Facultad de Fisica, Pontificia Universidad Catolica de Chile, Casilla 306, Santiago 22 (Chile); Broncano, Alicia [Max Planck Institute for Physics, Foehringer Ring 6, 80805 Munich (Germany); Belen Gavela, Maria [Departamento de Fisica Teorica and Instituto de Fisica Teorica, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Rigolin, Stefano [Departamento de Fisica Teorica and Instituto de Fisica Teorica, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Salvatori, Matteo [Departamento de Fisica Teorica and Instituto de Fisica Teorica, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain)

    2007-01-15

    Motivated by the electroweak hierarchy problem, we consider theories with two extra dimensions in which the four-dimensional scalar fields are components of gauge boson in full space. We explore the Nielsen-Olesen instability for SU(N) on a torus, in the presence of a magnetic background. A field theory approach is developed, computing explicitly the minimum of the complete effective potential, including tri-linear and quartic couplings and determining the symmetries of the stable vacua. We also develop appropriate gauge-fixing terms when both Kaluza-Klein and Landau levels are present and interacting, discussing the interplay between the possible six and four dimensional choices. The equivalence between coordinate dependent and constant Scherk-Schwarz boundary conditions - associated to either continuous or discrete Wilson lines - is analyzed.

  11. Dynamic Extra Buses Scheduling Strategy in Public Transport

    Directory of Open Access Journals (Sweden)

    Bin Yu

    2015-06-01

    Full Text Available This paper presents a dynamic extra buses scheduling strategy to improve the transit service of transit routes. In this strategy, in order to decide when to dispatch an extra bus, the service reliability of transit route is assessed firstly. A model aimed at maximizing the benefit of the extra buses scheduling strategy is constructed to determine how many stops extra buses need to skip from the terminal to accommodate passengers at the following stops. A heuristic algorithm is defined and implemented to estimate the service reliability of transit route and to optimize the initial stop of extra buses scheduling strategy. Finally, the strategy is tested on two examples: a simple and a real-life transit route in the Dalian city in China. The results show that the extra buses scheduling strategy based on terminal stops with a reasonable threshold can save 8.01% waiting time of passengers.

  12. Cosmologically safe QCD axion as a present from extra dimension

    Directory of Open Access Journals (Sweden)

    Masahiro Kawasaki

    2015-11-01

    Full Text Available We propose a QCD axion model where the origin of PQ symmetry and suppression of axion isocurvature perturbations are explained by introducing an extra dimension. Each extra quark–antiquark pair lives on branes separately to suppress PQ breaking operators. The size of the extra dimension changes after inflation due to an interaction between inflaton and a bulk scalar field, which implies that the PQ symmetry can be drastically broken during inflation to suppress undesirable axion isocurvature fluctuations.

  13. Cosmologically safe QCD axion as a present from extra dimension

    Energy Technology Data Exchange (ETDEWEB)

    Kawasaki, Masahiro [Institute for Cosmic Ray Research, The University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Yamada, Masaki, E-mail: yamadam@icrr.u-tokyo.ac.jp [Institute for Cosmic Ray Research, The University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Yanagida, Tsutomu T. [Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan)

    2015-11-12

    We propose a QCD axion model where the origin of PQ symmetry and suppression of axion isocurvature perturbations are explained by introducing an extra dimension. Each extra quark–antiquark pair lives on branes separately to suppress PQ breaking operators. The size of the extra dimension changes after inflation due to an interaction between inflaton and a bulk scalar field, which implies that the PQ symmetry can be drastically broken during inflation to suppress undesirable axion isocurvature fluctuations.

  14. Compact extra dimensions in cosmologies with f(T) structure

    CERN Document Server

    Fiorini, Franco; Vasquez, Yerko

    2013-01-01

    The presence of compact extra dimensions in cosmological scenarios in the context of f(T)-like gravities is discussed. For the case of toroidal compactifications, the analysis is performed in an arbitrary number of extra dimensions. Spherical topologies for the extra dimensions are then carefully studied in six and seven spacetime dimensions, where the proper vielbein fields responsible for the parallelization process are found.

  15. Science with the EXTraS Project: Exploring the X-ray Transient and variable Sky

    CERN Document Server

    De Luca, A; Tiengo, A; D'Agostino, D; Watson, M G; Haberl, F

    2015-01-01

    The EXTraS project (Exploring the X-ray Transient and variable Sky) will characterise the temporal behaviour of the largest ever sample of objects in the soft X-ray range (0.1-12 keV) with a complex, systematic and consistent analysis of all data collected by the European Photon Imaging Camera (EPIC) instrument onboard the ESA XMM-Newton X-ray observatory since its launch. We will search for, and characterize variability (both periodic and aperiodic) in hundreds of thousands of sources spanning more than nine orders of magnitude in time scale and six orders of magnitude in flux. We will also search for fast transients, missed by standard image analysis. Our analysis will be completed by multiwavelength characterization of new discoveries and phenomenological classification of variable sources. All results and products will be made available to the community in a public archive, serving as a reference for a broad range of astrophysical investigations.

  16. Extra relativistic degrees of freedom without extra particles using Planck data

    CERN Document Server

    Mastache, Jorge

    2013-01-01

    A recent number of analysis of cosmological data have shown indications for the presence of extra radiation beyond the standard model at equality and nucleosynthesis epoch, which has been usually interpreted as an effective number of neutrinos, Neff > 3.046. In this work we establish the theoretical basis for a particle physics-motivated model (Bound Dark Matter, BDM) which explain the need of extra radiation. The BDM model describes dark matter particles which are relativistic at a scale below aac due to non-perturbative methods, as protons and neutrons do, this process is described by a time dependent equation of state, w_bdm(a). We compute the range of values of the BDM model, xc=ac*vc, that explain the values obtain for the 4He at BBN and Neff at equality. Combining different analysis we conclude that this may happen in xc = 5.01 (^{+6.01}_{-5.01}) x 10^{-5} with a vc = 0.56 \\pm 0.39. We conclude that we can account for the apparent extra radiation Nex using phase transition in the dark matter with a time...

  17. Probing extra dimension through gravitational wave observations of compact binaries and their electromagnetic counterparts

    Science.gov (United States)

    Yu, Hao; Gu, Bao-Min; Huang, Fa Peng; Wang, Yong-Qiang; Meng, Xin-He; Liu, Yu-Xiao

    2017-02-01

    The future gravitational wave (GW) observations of compact binaries and their possible electromagnetic counterparts may be used to probe the nature of the extra dimension. It is widely accepted that gravitons and photons are the only two completely confirmed objects that can travel along null geodesics in our four-dimensional space-time. However, if there exist extra dimensions and only GWs can propagate freely in the bulk, the causal propagations of GWs and electromagnetic waves (EMWs) are in general different. In this paper, we study null geodesics of GWs and EMWs in a five-dimensional anti-de Sitter space-time in the presence of the curvature of the universe. We show that for general cases the horizon radius of GW is longer than EMW within equal time. Taking the GW150914 event detected by the Advanced Laser Interferometer Gravitational-Wave Observatory and the X-ray event detected by the Fermi Gamma-ray Burst Monitor as an example, we study how the curvature k and the constant curvature radius l affect the horizon radii of GW and EMW in the de Sitter and Einstein-de Sitter models of the universe. This provides an alternative method for probing extra dimension through future GW observations of compact binaries and their electromagnetic counterparts.

  18. Extra $Z^\\prime$s and $W^\\prime$s in Heterotic--String Derived Models

    CERN Document Server

    Faraggi, Alon E

    2015-01-01

    The ATLAS collaboration recently recorded possible excess in the di--boson production at the di--boson invariant mass at around 2 TeV. Such an excess may be produced if there exist additional $Z^\\prime$ and/or $W^\\prime$ at that scale. We survey the extra $Z^\\prime$s and $W^\\prime$s that may arise from semi--realistic heterotic string vacua in the free fermionic formulation in seven distinct cases including: $U(1)_{Z^\\prime}\\in SO(10)$; family universal $U(1)_{Z^\\prime}$ not in $SO(10)$; non--universal $U(1)_{Z^\\prime}$; hidden sector $U(1)$ symmetries and kinetic mixing; left--right symmetric models; Pati--Salam models; leptophobic and custodial symmetries. Each case has a distinct signature associated with the extra symmetry breaking scale. In one of the cases we explore the discovery potential at the LHC using resonant leptoproduction. Existence of extra vector boson with the reported properties will significantly constrain the space of allowed string vacua.

  19. Fermion Masses and Mixing in General Warped Extra Dimensional Models

    CERN Document Server

    Frank, Mariana; Pourtolami, Nima; Toharia, Manuel

    2015-01-01

    We analyze fermion masses and mixing in a general warped extra dimensional model, where all the Standard Model (SM) fields, including the Higgs, are allowed to propagate in the bulk. In this context, a slightly broken flavor symmetry imposed universally on all fermion fields, without distinction, can generate the full flavor structure of the SM, including quarks, charged leptons and neutrinos. For quarks and charged leptons, the exponential sensitivity of their wave-functions to small flavor breaking effects yield naturally hierarchical masses and mixing as it is usual in warped models with fermions in the bulk. In the neutrino sector, the exponential wave-function factors can be flavor-blind and thus insensitive to the small flavor symmetry breaking effects, directly linking their masses and mixing angles to the flavor symmetric structure of the 5D neutrino Yukawa couplings. The Higgs must be localized in the bulk and the model is naturally more successful in generalized warped scenarios where the metric bac...

  20. Can extra dimensional effects allow wormholes without exotic matter?

    Directory of Open Access Journals (Sweden)

    Sayan Kar

    2015-11-01

    Full Text Available We explore the existence of Lorentzian wormholes in the context of an effective on-brane, scalar-tensor theory of gravity. In such theories, the timelike convergence condition, which is always violated for wormholes, has contributions, via the field equations, from on-brane matter as well as from an effective geometric stress energy generated by a bulk-induced radion field. It is shown that, for a class of wormholes, the required on-brane matter, as seen by an on-brane observer in the Jordan frame, is not exotic and does not violate the Weak Energy Condition. The presence of the effective geometric stress energy in addition to on-brane matter is largely responsible for creating this intriguing possibility. Thus, if such wormholes are ever found to exist in the Universe, they would clearly provide pointers towards the existence of a warped extra dimension as proposed in the two-brane model of Randall and Sundrum.

  1. Photon mass as a probe to extra dimensions

    CERN Document Server

    Alencar, G; Landim, R R; Jardim, I C; Filho, R N Costa

    2015-01-01

    In this manuscript we show that the geometrical localization mechanism implies a four dimensional mass for the photon. The consistence of the model provides a mass given exactly by $m_{\\gamma}=\\sqrt{R}/4$ where $R$ is the Ricci scalar. As a consequence, the cosmological photon has a mass related to the vacuum solution of the Einstein equation. At the present age of the universe we have a dS vacuum with $R=\\Lambda$, where Lambda is a positive cosmological constant. With this we find that $m_{\\gamma}\\approx 2\\times 10^{-69}$ kg, which is below the present experimental upper bounds, and such correction may be observed in the next years with more precise measurements. By considering the value of $R$ inside some astrophysical sources and environments we find that the bound is also satisfied. The experimental verification of this mass, beyond pointing to the existence of extra dimensions, would imply in a fundamental change in cosmology, astrophysics and in particle physics since the same mechanism is valid for non...

  2. Photon mass as a probe to extra dimensions

    Science.gov (United States)

    Alencar, G.; Muniz, C. R.; Landim, R. R.; Jardim, I. C.; Costa Filho, R. N.

    2016-08-01

    In this manuscript we show that the geometrical localization mechanism implies a four dimensional mass for the photon. The consistence of the model provides a mass given exactly by mγ =√{ R} / 4 where R is the Ricci scalar. As a consequence, the cosmological photon has a mass related to the vacuum solution of the Einstein equation. At the present age of the universe we have a dS vacuum with R = 4 Λ, where Lambda is a positive cosmological constant. With this we find that mγ ≈ 2 ×10-69 kg, which is below the present experimental upper bounds, and such correction may be observed in the next years with more precise measurements. By considering the value of R inside some astrophysical sources and environments we find that the bound is also satisfied. The experimental verification of this mass, beyond pointing to the existence of extra dimensions, would imply in a fundamental change in cosmology, astrophysics and in particle physics.

  3. Fermion masses and mixing in general warped extra dimensional models

    Science.gov (United States)

    Frank, Mariana; Hamzaoui, Cherif; Pourtolami, Nima; Toharia, Manuel

    2015-06-01

    We analyze fermion masses and mixing in a general warped extra dimensional model, where all the Standard Model (SM) fields, including the Higgs, are allowed to propagate in the bulk. In this context, a slightly broken flavor symmetry imposed universally on all fermion fields, without distinction, can generate the full flavor structure of the SM, including quarks, charged leptons and neutrinos. For quarks and charged leptons, the exponential sensitivity of their wave functions to small flavor breaking effects yield hierarchical masses and mixing as it is usual in warped models with fermions in the bulk. In the neutrino sector, the exponential wave-function factors can be flavor blind and thus insensitive to the small flavor symmetry breaking effects, directly linking their masses and mixing angles to the flavor symmetric structure of the five-dimensional neutrino Yukawa couplings. The Higgs must be localized in the bulk and the model is more successful in generalized warped scenarios where the metric background solution is different than five-dimensional anti-de Sitter (AdS5 ). We study these features in two simple frameworks, flavor complimentarity and flavor democracy, which provide specific predictions and correlations between quarks and leptons, testable as more precise data in the neutrino sector becomes available.

  4. 29 CFR 541.604 - Minimum guarantee plus extras.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Minimum guarantee plus extras. 541.604 Section 541.604 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS... SALES EMPLOYEES Salary Requirements § 541.604 Minimum guarantee plus extras. (a) An employer may...

  5. Direct Detection of Extra-Solar Comets is Possible

    OpenAIRE

    Jura, M.

    2005-01-01

    The dust tails of comets similar to Hale-Bopp can scatter as much optical light as does the Earth. Space-based observatories such as the Terrestrial Planet Finder or Darwin that will detect extra-solar terrestrial planets also will be able to detect extra-solar comets.

  6. Fundamental and composite scalars from extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Aranda, Alfredo [Dual C-P Institute of High Energy Physics, Facultad de Ciencias, Universidad de Colima, Bernal Diaz del Castillo 340, Colima, Colima (Mexico)], E-mail: fefo@ucol.mx; Diaz-Cruz, J.L. [Dual C-P Institute of High Energy Physics, Facultad de Ciencias, Universidad de Colima, Bernal Diaz del Castillo 340, Colima, Colima (Mexico); Dual C-P Institute of High Energy Physics, Facultad de Ciencias Fisico-Matematicas, BUAP, Apdo. Postal 1364, C.P. 72000 Puebla, Pue (Mexico)], E-mail: lorenzo.diaz@fcfm.buap.mx; Hernandez-Sanchez, J. [Dual C-P Institute of High Energy Physics, Centro de Investigacion en Matematicas, Universidad Autonoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo km. 4.5, C.P. 42184, Pachuca, Hidalgo (Mexico)], E-mail: jaimeh@uaeh.edu.mx; Noriega-Papaqui, R. [Dual C-P Institute of High Energy Physics, Instituto de Fisica, Universidad Nacional Autonoma de Mexico, Apdo. Postal 20-364, 01000 Mexico D.F. (Mexico)], E-mail: rnoriega@fisica.unam.mx

    2007-12-13

    We discuss a scenario consisting of an effective 4D theory containing fundamental and composite fields. The strong dynamics sector responsible for the compositeness is assumed to be of extra dimensional origin. In the 4D effective theory the SM fermion and gauge fields are taken as fundamental fields. The scalar sector of the theory resembles a bosonic topcolor in the sense there are two scalar Higgs fields, a composite scalar field and a fundamental gauge-Higgs unification scalar. A detailed analysis of the scalar spectrum is presented in order to explore the parameter space consistent with experiment. It is found that, under the model assumptions, the acceptable parameter space is quite constrained. As a part of our phenomenological study of the model, we evaluate the branching ratio of the lightest Higgs boson and find that our model predicts a large FCNC mode h{yields}tc, which can be as large as O(10{sup -3}). Similarly, a large BR for the top FCNC decay is obtained, namely BR(t{yields}c+H){approx_equal}10{sup -4}.

  7. Girls and war: an extra vulnerability.

    Science.gov (United States)

    Black, M

    1998-01-01

    It is no longer possible to consider the raping of girls as an isolated atrocity of war. In Uganda, guerrilla forces have kidnapped 6000-10,000 children and have forced the "most desirable" girls to become "wives" of warlords. Girls who manage to escape are deeply traumatized and suffer ill health as well as possible social ostracism. In refugee camps, recognition that adolescent girls face special risks of rape and of engaging in the informal prostitution that may expose them to HIV/AIDS has led to the introduction of new measures to increase female security. Families in refugee camps in Burundi and Somalia protect female honor by submitting their daughters to very early marriage, which also abuses the girls' rights. Girls conscripted to military groups are forced to transport materials, cook, or help loot villages. In conditions of war, even girls who remain at home protected by their families must assume extra responsibilities, especially if men go off to fight leaving women with the agricultural and livestock burdens. Girls will be the first children withdrawn from school to help keep the household afloat. Girls and women are also expected to tend those wounded by the very war that destroys the health care services that are vital to meet women's reproductive needs. Efforts are being made to identify rape as a specific war crime, and these efforts should be extended to the kidnapping and forced recruitment of children into combat roles. Moral codes must be reestablished, even if they are only nominal at present.

  8. Diphoton Resonance from a Warped Extra Dimension

    CERN Document Server

    Bauer, Martin; Neubert, Matthias

    2016-01-01

    We argue that extensions of the Standard Model (SM) with a warped extra dimension, which successfully address the hierarchy and flavor problems of elementary particle physics, can provide an elegant explanation of the 750 GeV diphoton excess recently reported by ATLAS and CMS. A gauge-singlet bulk scalar with O(1) couplings to fermions is identified as the new resonance S, and the vector-like Kaluza-Klein excitations of the SM quarks and leptons mediate its loop-induced couplings to photons and gluons. The electroweak gauge symmetry almost unambiguously dictates the bulk matter content and hence the hierarchies of the S->\\gamma\\gamma, WW, ZZ, Z\\gamma, t\\bar t and dijet decay rates. We find that the S->Z\\gamma decay mode is strongly suppressed, such that Br(S->Z\\gamma)Br(S->\\gamma\\gamma)S->\\gamma\\gamma signal requires Kaluza-Klein masses in the multi-TeV range, in perfect agreement with bounds from flavor physics and electroweak precision observables.

  9. Gravitation, holographic principle, and extra dimensions

    CERN Document Server

    Caimmi, R

    2016-01-01

    Within the context of Newton's theory of gravitation, restricted to point-like test particles and central bodies, stable circular orbits in ordinary space are related to stable circular paths on a massless, unmovable, undeformable vortex-like surface, under the action of a tidal gravitational field along the symmetry axis. An interpretation is made in the light of a holographic principle, in the sense that motions in ordinary space are connected with motions on a selected surface and vice versa. Then ordinary space is conceived as a 3-hypersurface bounding a $n$-hypervolume where gravitation takes origin, within a $n$-hyperspace. The extension of the holographic principle to extra dimensions implies the existence of a minimum distance where test particles may still be considered as distinct from the central body. Below that threshold, it is inferred test particles lose theirs individuality and "glue" to the central body via unification of the four known interactions and, in addition, (i) particles can no long...

  10. Diphoton resonance from a warped extra dimension

    Science.gov (United States)

    Bauer, Martin; Hörner, Clara; Neubert, Matthias

    2016-07-01

    We argue that extensions of the Standard Model (SM) with a warped extra dimension, which successfully address the hierarchy and flavor problems of elementary particle physics, can provide an elegant explanation of the 750 GeV diphoton excess recently reported by ATLAS and CMS. A gauge-singlet bulk scalar with {O} (1) couplings to fermions is identified as the new resonance S, and the vector-like Kaluza-Klein excitations of the SM quarks and leptons mediate its loop-induced couplings to photons and gluons. The electroweak gauge symmetry almost unambiguously dictates the bulk matter content and hence the hierarchies of the Sto γ γ, W W,ZZ,Zγ, toverline{t} and dijet decay rates. We find that the S → Zγ decay mode is strongly suppressed, such that Br( S → Zγ) /Br( S → γγ) converge and can be calculated in closed form with a remarkably simple result. Reproducing the observed pp → S → γγ signal requires Kaluza-Klein masses in the multi-TeV range, consistent with bounds from flavor physics and electroweak precision observables.

  11. Brane Stabilization and Regionality of Extra Dimensions

    CERN Document Server

    Jacobs, David M; Tolley, Andrew J

    2012-01-01

    Extra dimensions are a common feature of beyond the Standard Model physics. In a braneworld scenario, local physics on the brane can depend strongly on the brane's location within the bulk. Generically, the relevant properties of the bulk manifold for the physics on/of the brane are neither local nor global, but depend on the structure of finite regions of the bulk, even for locally homogeneous and isotropic bulk geometries. In a recent work, various mechanisms (in a braneworld context) were considered to stabilize the location of a brane within bulk spaces of non-trivial topology. In this work we elaborate on and generalize that work by considering additional bulk and brane dimensionalities as well as different boundary conditions on the bulk scalar field that provides a Casimir force on the brane, providing further insight on this effect. In D=2+1 (D=5+1) we consider both local and global contributions to the effective potential of a 1-brane (4-brane) wrapped around both the 2-dimensional hyperbolic horn an...

  12. LHC Signals from Warped Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Agashe, K.; Belyaev, A.; Krupovnickas, T.; Perez, G.; Virzi, J.

    2006-12-06

    We study production of Kaluza-Klein gluons (KKG) at the Large Hadron Collider (LHC) in the framework of a warped extra dimension with the Standard Model (SM) fields propagating in the bulk. We show that the detection of KK gluon is challenging since its production is suppressed by small couplings to the proton's constituents. Moreover, the KK gluon decaysmostly to top pairs due to an enhanced coupling and hence is broad. Nevertheless, we demonstrate that for MKKG<~;; 4 TeV, 100 fb-1 of data at the LHC can provide discovery of the KK gluon. We utilize a sizeable left-right polarization asymmetry from the KK gluon resonance to maximize the signal significance, and we explore the novel feature of extremely highly energetic"top-jets." We briefly discuss how the detection of electroweak gauge KK states (Z/W) faces a similar challenge since their leptonic decays ("golden" modes) are suppressed. Our analysis suggests that other frameworks, for example little Higgs, which rely on UV completion via strong dynamics might face similar challenges, namely (1) Suppressed production rates for the new particles (such as Z'), due to their"lightfermion-phobic" nature, and (2) Difficulties in detection since the new particles are broad and decay predominantly to third generation quarks and longitudinal gauge bosons.

  13. Extra cellular matrix features in human meninges.

    Science.gov (United States)

    Montagnani, S; Castaldo, C; Di Meglio, F; Sciorio, S; Giordano-Lanza, G

    2000-01-01

    We collected human fetal and adult normal meninges to relate the age of the tissue with the presence of collagenous and non-collagenous components of Extra Cellular Matrix (ECM). Immunohistochemistry led us to observe some differences in the amount and in the distribution of these proteins between the two sets of specimens. In particular, laminin and tenascin seem to be expressed more intensely in fetal meninges when compared to adult ones. In order to investigate whether the morphofunctional characteristics of fetal meninges may be represented in pathological conditions we also studied meningeal specimens from human meningiomas. Our attention was particularly focused on the expression of those non-collagenous proteins involved in nervous cell migration and neuronal morphogenesis as laminin and tenascin, which were present in lesser amount in normal adult specimens. Microscopical evidences led us to hipothesize that these proteins which are synthesized in a good amount during the fetal development of meninges can be newly produced in tumors. On the contrary, the role of tenascin and laminin in adult meninges is probably only interesting for their biophysical characteristics.

  14. Casimir Dark Energy, Stabilization of the Extra Dimensions and Gauss-Bonnet Term

    CERN Document Server

    Wongjun, Pitayuth

    2013-01-01

    Casimir dark energy model in five-dimensional and six-dimensional spacetime including non-relativistic matter and Gauss-Bonnet term is investigated. The Casimir energy can play the role of dark energy to drive the late-time acceleration of the universe while the radius of the extra dimensions can be stabilized. The qualitative analysis in radion picture in four-dimensional spacetime shows that the contribution from Gauss-Bonnet term will effectively slows down the radion field at the beginning time. Therefore, the radion field does not pass minimum point of the effective potential before the minimum the potential exists. This leads to the stabilizing mechanism of the extra dimensions eventually.

  15. Extra Dimensions and Vacuum Dark Energy Models

    Institute of Scientific and Technical Information of China (English)

    CHEN Chi-Yi; SHEN You-Gen

    2004-01-01

    @@ The role of vacuum energy or cosmological constant in cosmology is discussed in a kind of nontrivial higherdimensional model. Under the framework of Einstein's gravity, we obtain the corresponding equations of motion and find that the cosmological constant and vacuum energy in the full regime does not drive its acceleration, but decelerates the expansion of the universe. The dimension of space is required to be n = 3 if we regard vacuum energy or cosmological constant as the candidate to drive the accelerated expansion of the universe.

  16. Error bounds from extra precise iterative refinement

    Energy Technology Data Exchange (ETDEWEB)

    Demmel, James; Hida, Yozo; Kahan, William; Li, Xiaoye S.; Mukherjee, Soni; Riedy, E. Jason

    2005-02-07

    We present the design and testing of an algorithm for iterative refinement of the solution of linear equations, where the residual is computed with extra precision. This algorithm was originally proposed in the 1960s [6, 22] as a means to compute very accurate solutions to all but the most ill-conditioned linear systems of equations. However two obstacles have until now prevented its adoption in standard subroutine libraries like LAPACK: (1) There was no standard way to access the higher precision arithmetic needed to compute residuals, and (2) it was unclear how to compute a reliable error bound for the computed solution. The completion of the new BLAS Technical Forum Standard [5] has recently removed the first obstacle. To overcome the second obstacle, we show how a single application of iterative refinement can be used to compute an error bound in any norm at small cost, and use this to compute both an error bound in the usual infinity norm, and a componentwise relative error bound. We report extensive test results on over 6.2 million matrices of dimension 5, 10, 100, and 1000. As long as a normwise (resp. componentwise) condition number computed by the algorithm is less than 1/max{l_brace}10,{radical}n{r_brace} {var_epsilon}{sub w}, the computed normwise (resp. componentwise) error bound is at most 2 max{l_brace}10,{radical}n{r_brace} {center_dot} {var_epsilon}{sub w}, and indeed bounds the true error. Here, n is the matrix dimension and w is single precision roundoff error. For worse conditioned problems, we get similarly small correct error bounds in over 89.4% of cases.

  17. National extra heavy crude oil upgrade; Melhoramento de petroleos extra pesados nacionais no ambiente de producao

    Energy Technology Data Exchange (ETDEWEB)

    Medina, Lilian Camen; Zilio, Evaldo L.; Guimarae, Regina C.; Tosta, Luiz C. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil). Centro de Pesquisas; Barros, Ricardo S. de [Fundacao Universitaria Jose Bonifacio (FUJB), Rio de Janeiro, RJ (Brazil); Leite, Luiz Fernando T. [PETROBRAS S.A., Vitoria, ES (Brazil). Unidade de Negocios-ES

    2008-07-01

    Brazilian petroleums are becoming increasingly heavy, reaching values of up to 7 deg API, which classifies them as extra heavy. They are also very viscous, sometimes presenting values as 10184 mm{sup 2}/s to 50 deg C. These two factors affect production operations like lifting, flow assurance and primary processing, with implications on transporting and refining. Trading these kinds of oils is also difficult; once there are not many refineries in the world able to process them. Due to these facts and also to the lower yield on premium products, the international market value is lower than the reference oil, for example, oil 'Brent'. Studies indicate that in some heavy oils fields the process of well lifting and also the flow in pipelines is almost impracticable in a first analysis, mainly offshore field, impacting both technically and economically the development of the production of a new field. Therefore it becomes necessary implement efforts to develop alternatives to increase oil's API density and at the same time reduce the viscosity of extra heavy oil inside the well, i.e. through a process of upgrading assuring its flow and consequently their production, primary processing and refining, increasing, the value of marketing. (author)

  18. Effects of extra virgin olive oil and fish oil on lipid profile and oxidative stress in patients with metabolic syndrome.

    Science.gov (United States)

    Venturini, Danielle; Simão, Andréa Name Colado; Urbano, Mariana Ragassi; Dichi, Isaias

    2015-06-01

    The aim of this study was to verify if extra virgin olive oil and fish oil have a synergistic effect on lipid and oxidative stress parameters in patients with metabolic syndrome (MetS). This intervention study included 102 patients (81 women and 21 men) with MetS (mean age 51.45 ± 8.27 y) from the ambulatory center of the University Hospital of Londrina, Paraná, Brazil. Patients were randomly assigned to one of four groups: Patients in the control group (CG) were instructed to maintain their usual diet; the second group (fish oil group [FO]) received 3 g/d of fish oil ω-3 fatty acids (10 capsules); the third group (extra virgin olive oil group [OO]) received 10 mL/d of extra virgin olive oil at lunch and dinner; and the fourth group (fish oil and extra virgin olive oil group [FOO]) received 3 g/d of fish oil ω-3 fatty acids and 10 mL/d of extra virgin olive oil. MetS related markers and oxidative stress were measured at baseline and after 90 d. Differences across treatment groups showed a statistically significant decrease (P olive oil have beneficial synergistic effects on lipid metabolism and oxidative stress in patients with MetS. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Messaging to Extra-Terrestrial Intelligence

    CERN Document Server

    Zaitsev, A

    2006-01-01

    Throughout the entire history of terrestrial civilization, only four projects involving transmitting of interstellar radio messages (IRMs) have yet been fully developed and realized. Nevertheless, we should understand a simple thing -- if all civilizations in the Universe are only recipients, and not message-sending civilizations, than no SETI searches make any sense. We present the theory and methodology of composing and transmitting of future IRMs.

  20. Search for Large Extra Dimensions in Dielectron and Diphoton Production

    CERN Document Server

    Abbott, B; Abramov, V; Acharya, B S; Adams, D L; Adams, M; Alves, G A; Amos, N; Anderson, E W; Baarmand, M M; Babintsev, V V; Babukhadia, L R; Baden, A; Baldin, B Yu; Balm, P W; Banerjee, S; Bantly, J; Barberis, E; Baringer, P; Bartlett, J F; Bassler, U; Bean, A; Begel, M; Belyaev, A; Beri, S B; Bernardi, G; Bertram, I; Besson, A; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Bhattacharjee, M; Blazey, G C; Blessing, S; Böhnlein, A; Bozhko, N; Borcherding, F; Brandt, A; Breedon, R; Briskin, G M; Brock, R; Brooijmans, G; Bross, A; Buchholz, D; Bühler, M; Büscher, V; Burtovoi, V S; Butler, J M; Canelli, F; Carvalho, W S; Casey, D; Casilum, Z; Castilla-Valdez, H; Chakraborty, D; Chan, K M; Chekulaev, S V; Cho, D K; Choi, S; Chopra, S; Christenson, J H; Chung, M; Claes, D; Clark, A R; Cochran, J; Coney, L; Connolly, B; Cooper, W E; Coppage, D; Cummings, M A C; Cutts, D; Dahl, O I; Davis, G A; Davis, K; De, K; Del Signore, K; Demarteau, M; Demina, R; Demine, P; Denisov, D S; Denisov, S P; Desai, S V; Diehl, H T; Diesburg, M; DiLoreto, G; Doulas, S; Draper, P; Ducros, Y; Dudko, L V; Duensing, S; Dugad, S R; Dyshkant, A; Edmunds, D L; Ellison, J; Elvira, V D; Engelmann, R; Eno, S; Eppley, G; Ermolov, P; Eroshin, O V; Estrada, J K; Evans, H; Evdokimov, V N; Fahland, T; Fehér, S; Fein, D; Ferbel, T; Fisk, H E; Fisyak, Yu; Flattum, E M; Fleuret, F; Fortner, M R; Frame, K C; Fuess, S; Gallas, E J; Galjaev, A N; Gartung, P E; Gavrilov, V; Genik, R J; Genser, K; Gerber, C E; Gershtein, Yu; Gibbard, B; Gilmartin, R; Ginther, G; Gómez, B; Gómez, G; Goncharov, P I; González-Solis, J L; Gordon, H; Goss, L T; Gounder, K; Goussiou, A; Graf, N; Graham, G; Grannis, P D; Green, J A; Greenlee, H; Grinstein, S; Groer, L S; Grudberg, P M; Grünendahl, S; Sen-Gupta, A; Gurzhev, S N; Gutíerrez, G; Gutíerrez, P; Hadley, N J; Haggerty, H; Hagopian, S L; Hagopian, V; Hahn, K S; Hall, R E; Hanlet, P; Hansen, S; Hauptman, J M; Hays, C; Hebert, C; Hedin, D; Heinson, A P; Heintz, U; Heuring, T C; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hoftun, J S; Hou, S; Huang, Y; Ito, A S; Jerger, S A; Jesik, R; Johns, K; Johnson, M; Jonckheere, A M; Jones, M; Jöstlein, H; Juste, A; Kahn, S; Kajfasz, E; Karmanov, D E; Karmgard, D J; Kehoe, R; Kim, S K; Klima, B; Klopfenstein, C; Knuteson, B; Ko, W; Kohli, J M; Kostritskii, A V; Kotcher, J; Kotwal, A V; Kozelov, A V; Kozlovskii, E A; Krane, J; Krishnaswamy, M R; Krzywdzinski, S; Kubantsev, M A; Kuleshov, S; Kulik, Y; Kunori, S; Kuznetsov, V E; Landsberg, G L; Leflat, A; Lehner, F; Li, J; Li, Q Z; Lima, J G R; Lincoln, D; Linn, S L; Linnemann, J T; Lipton, R; Lucotte, A; Lueking, L H; Lundstedt, C; Maciel, A K A; Madaras, R J; Manankov, V; Mao, H S; Marshall, T; Martin, M I; Martin, R D; Mauritz, K M; May, B; Mayorov, A A; McCarthy, R; McDonald, J; McMahon, T; Melanson, H L; Meng, X C; Merkin, M; Merritt, K W B; Miao, C; Miettinen, H; Mihalcea, D; Mincer, A; Mishra, C S; Mokhov, N V; Mondal, N K; Montgomery, H E; Moore, R W; Mostafa, M A; Da Motta, H; Nagy, E; Nang, F; Narain, M; Narasimham, V S; Neal, H A; Negret, J P; Negroni, S; Norman, D; Oesch, L H; Oguri, V; Olivier, B; Oshima, N; Padley, P; Pan, L J; Para, A; Parashar, N; Partridge, R; Parua, N; Paterno, M; Patwa, A; Pawlik, B; Perkins, J; Peters, M; Peters, O; Piegaia, R; Piekarz, H; Pope, B G; Popkov, E; Prosper, H B; Protopopescu, S D; Qian, J; Quintas, P Z; Raja, R; Rajagopalan, S; Ramberg, E; Rapidis, P A; Reay, N W; Reucroft, S; Rha, J; Rijssenbeek, M; Rockwell, T; Roco, M T; Rubinov, P M; Ruchti, R C; Rutherfoord, John P; Santoro, A F S; Sawyer, L; Schamberger, R D; Schellman, H; Schwartzman, A; Scully, J R; Sen, N; Shabalina, E; Shankar, H C; Shivpuri, R K; Shpakov, D; Shupe, M A; Sidwell, R A; Simák, V; Singh, H; Singh, J B; Sirotenko, V I; Slattery, P F; Smith, E; Smith, R P; Snihur, R; Snow, G A; Snow, J; Snyder, S; Solomon, J; Sorin, V; Sosebee, M; Sotnikova, N; Soustruznik, K; Souza, M; Stanton, N R; Steinbruck, G; Stephens, R W; Stevenson, M L; Stichelbaut, F; Stoker, D; Stolin, V; Stoyanova, D A; Strauss, M; Streets, K; Strovink, M; Stutte, L; Sznajder, A; Taylor, W; Tentindo-Repond, S; Thompson, J; Toback, D; Tripathi, S M; Trippe, T G; Turcot, A S; Tuts, P M; Van Gemmeren, P; Vaniev, V; Van Kooten, R; Varelas, N; Volkov, A A; Vorobev, A P; Wahl, H D; Wang, H; Wang, Z M; Warchol, J; Watts, G; Wayne, M; Weerts, H; White, A; White, J T; Whiteson, D; Wightman, J A; Wijngaarden, D A; Willis, S; Wimpenny, S J; Wirjawan, J V D; Womersley, J; Wood, D R; Yamada, R; Yamin, P; Yasuda, T; Yip, K; Youssef, S; Yu, J; Yu, Z; Zanabria, M E; Zheng, H; Zhou, Z; Zhu, Z H; Zielinski, M; Zieminska, D; Zieminski, A; Zutshi, V; Zverev, E G; Zylberstejn, A

    2001-01-01

    We report a search for effects of large extra spatial dimensions in ppbar collisions at a center-of-mass energy of 1.8 TeV with the DZero detector, using events containing a pair of electrons or photons. The data are in good agreement with the expected background and do not exhibit evidence for large extra dimensions. We set the most restrictive lower limits to date, at the 95% confidence level, on the effective Planck scale between 1.0 TeV and 1.4 TeV for several formalisms and numbers of extra dimensions.

  1. Search for Large Extra Dimensions in Dielectron and Diphoton Production

    Science.gov (United States)

    Abbott, B.; Abolins, M.; Abramov, V.; Acharya, B. S.; Adams, D. L.; Adams, M.; Alves, G. A.; Amos, N.; Anderson, E. W.; Baarmand, M. M.; Babintsev, V. V.; Babukhadia, L.; Baden, A.; Baldin, B.; Balm, P. W.; Banerjee, S.; Bantly, J.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bean, A.; Begel, M.; Belyaev, A.; Beri, S. B.; Bernardi, G.; Bertram, I.; Besson, A.; Bezzubov, V. A.; Bhat, P. C.; Bhatnagar, V.; Bhattacharjee, M.; Blazey, G.; Blessing, S.; Boehnlein, A.; Bojko, N. I.; Borcherding, F.; Brandt, A.; Breedon, R.; Briskin, G.; Brock, R.; Brooijmans, G.; Bross, A.; Buchholz, D.; Buehler, M.; Buescher, V.; Burtovoi, V. S.; Butler, J. M.; Canelli, F.; Carvalho, W.; Casey, D.; Casilum, Z.; Castilla-Valdez, H.; Chakraborty, D.; Chan, K. M.; Chekulaev, S. V.; Cho, D. K.; Choi, S.; Chopra, S.; Christenson, J. H.; Chung, M.; Claes, D.; Clark, A. R.; Cochran, J.; Coney, L.; Connolly, B.; Cooper, W. E.; Coppage, D.; Cummings, M. A.; Cutts, D.; Dahl, O. I.; Davis, G. A.; Davis, K.; de, K.; del Signore, K.; Demarteau, M.; Demina, R.; Demine, P.; Denisov, D.; Denisov, S. P.; Desai, S.; Diehl, H. T.; Diesburg, M.; di Loreto, G.; Doulas, S.; Draper, P.; Ducros, Y.; Dudko, L. V.; Duensing, S.; Dugad, S. R.; Dyshkant, A.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Engelmann, R.; Eno, S.; Eppley, G.; Ermolov, P.; Eroshin, O. V.; Estrada, J.; Evans, H.; Evdokimov, V. N.; Fahland, T.; Feher, S.; Fein, D.; Ferbel, T.; Fisk, H. E.; Fisyak, Y.; Flattum, E.; Fleuret, F.; Fortner, M.; Frame, K. C.; Fuess, S.; Gallas, E.; Galyaev, A. N.; Gartung, P.; Gavrilov, V.; Genik, R. J.; Genser, K.; Gerber, C. E.; Gershtein, Y.; Gibbard, B.; Gilmartin, R.; Ginther, G.; Gómez, B.; Gómez, G.; Goncharov, P. I.; González Solís, J. L.; Gordon, H.; Goss, L. T.; Gounder, K.; Goussiou, A.; Graf, N.; Graham, G.; Grannis, P. D.; Green, J. A.; Greenlee, H.; Grinstein, S.; Groer, L.; Grudberg, P.; Grünendahl, S.; Gupta, A.; Gurzhiev, S. N.; Gutierrez, G.; Gutierrez, P.; Hadley, N. J.; Haggerty, H.; Hagopian, S.; Hagopian, V.; Hahn, K. S.; Hall, R. E.; Hanlet, P.; Hansen, S.; Hauptman, J. M.; Hays, C.; Hebert, C.; Hedin, D.; Heinson, A. P.; Heintz, U.; Heuring, T.; Hirosky, R.; Hobbs, J. D.; Hoeneisen, B.; Hoftun, J. S.; Hou, S.; Huang, Y.; Ito, A. S.; Jerger, S. A.; Jesik, R.; Johns, K.; Johnson, M.; Jonckheere, A.; Jones, M.; Jöstlein, H.; Juste, A.; Kahn, S.; Kajfasz, E.; Karmanov, D.; Karmgard, D.; Kehoe, R.; Kim, S. K.; Klima, B.; Klopfenstein, C.; Knuteson, B.; Ko, W.; Kohli, J. M.; Kostritskiy, A. V.; Kotcher, J.; Kotwal, A. V.; Kozelov, A. V.; Kozlovsky, E. A.; Krane, J.; Krishnaswamy, M. R.; Krzywdzinski, S.; Kubantsev, M.; Kuleshov, S.; Kulik, Y.; Kunori, S.; Kuznetsov, V. E.; Landsberg, G.; Leflat, A.; Lehner, F.; Li, J.; Li, Q. Z.; Lima, J. G.; Lincoln, D.; Linn, S. L.; Linnemann, J.; Lipton, R.; Lucotte, A.; Lueking, L.; Lundstedt, C.; Maciel, A. K.; Madaras, R. J.; Manankov, V.; Mao, H. S.; Marshall, T.; Martin, M. I.; Martin, R. D.; Mauritz, K. M.; May, B.; Mayorov, A. A.; McCarthy, R.; McDonald, J.; McMahon, T.; Melanson, H. L.; Meng, X. C.; Merkin, M.; Merritt, K. W.; Miao, C.; Miettinen, H.; Mihalcea, D.; Mincer, A.; Mishra, C. S.; Mokhov, N.; Mondal, N. K.; Montgomery, H. E.; Moore, R. W.; Mostafa, M.; da Motta, H.; Nagy, E.; Nang, F.; Narain, M.; Narasimham, V. S.; Neal, H. A.; Negret, J. P.; Negroni, S.; Norman, D.; Oesch, L.; Oguri, V.; Olivier, B.; Oshima, N.; Padley, P.; Pan, L. J.; Para, A.; Parashar, N.; Partridge, R.; Parua, N.; Paterno, M.; Patwa, A.; Pawlik, B.; Perkins, J.; Peters, M.; Peters, O.; Piegaia, R.; Piekarz, H.; Pope, B. G.; Popkov, E.; Prosper, H. B.; Protopopescu, S.; Qian, J.; Quintas, P. Z.; Raja, R.; Rajagopalan, S.; Ramberg, E.; Rapidis, P. A.; Reay, N. W.; Reucroft, S.; Rha, J.; Rijssenbeek, M.; Rockwell, T.; Roco, M.; Rubinov, P.; Ruchti, R.; Rutherfoord, J.; Santoro, A.; Sawyer, L.; Schamberger, R. D.; Schellman, H.; Schwartzman, A.; Sculli, J.; Sen, N.; Shabalina, E.; Shankar, H. C.; Shivpuri, R. K.; Shpakov, D.; Shupe, M.; Sidwell, R. A.; Simak, V.; Singh, H.; Singh, J. B.; Sirotenko, V.; Slattery, P.; Smith, E.; Smith, R. P.; Snihur, R.; Snow, G. R.; Snow, J.; Snyder, S.; Solomon, J.; Sorín, V.; Sosebee, M.; Sotnikova, N.; Soustruznik, K.; Souza, M.; Stanton, N. R.; Steinbrück, G.; Stephens, R. W.; Stevenson, M. L.; Stichelbaut, F.; Stoker, D.; Stolin, V.; Stoyanova, D. A.; Strauss, M.; Streets, K.; Strovink, M.; Stutte, L.; Sznajder, A.; Taylor, W.; Tentindo-Repond, S.; Thompson, J.; Toback, D.; Tripathi, S. M.; Trippe, T. G.; Turcot, A. S.; Tuts, P. M.; van Gemmeren, P.; Vaniev, V.; van Kooten, R.; Varelas, N.; Volkov, A. A.; Vorobiev, A. P.; Wahl, H. D.; Wang, H.; Wang, Z.-M.; Warchol, J.; Watts, G.; Wayne, M.; Weerts, H.; White, A.; White, J. T.; Whiteson, D.; Wightman, J. A.; Wijngaarden, D. A.; Willis, S.; Wimpenny, S. J.; Wirjawan, J. V.; Womersley, J.; Wood, D. R.; Yamada, R.; Yamin, P.; Yasuda, T.; Yip, K.; Youssef, S.; Yu, J.; Yu, Z.; Zanabria, M.; Zheng, H.; Zhou, Z.; Zhu, Z. H.; Zielinski, M.; Zieminska, D.; Zieminski, A.; Zutshi, V.; Zverev, E. G.; Zylberstejn, A.

    2001-02-01

    We report a search for effects of large extra spatial dimensions in pp¯ collisions at a center-of-mass energy of 1.8 TeV with the D0 detector, using events containing a pair of electrons or photons. The data are in good agreement with the expected background and do not exhibit evidence for large extra dimensions. We set the most restrictive lower limits to date, at the 95% C.L. on the effective Planck scale between 1.0 and 1.4 TeV for several formalisms and numbers of extra dimensions.

  2. Intersection democracy for winding branes and stabilization of extra dimensions

    CERN Document Server

    Rador, Tonguc

    2005-01-01

    We show that, in the context of pure Einstein gravity, a democratic principle for intersection possibilities of branes winding around extra dimensions in a given partitioning yield stabilization, while what the observed space follows is matter-like dust evolution . Here democracy is used in the sense that, in a given decimation of extra dimensions, all possible wrappings and hence all possible intersections are allowed. Generally, the necessary and sufficient condition for this is that the dimensionality $m$ of the observed space dimensions obey $3\\leqm \\le N$ where $N$ is the decimation order of the extra dimensions.

  3. La inquietante extrañeza en el cine

    OpenAIRE

    Antelo, Marcela

    2015-01-01

    La inquietante extrañeza en el cine parte de considerar la experiencia cinematográfica como un acontecimiento de la sensibilidad. La sala oscura proporciona una intimidad con extraños, y el silencio y la oscuridad evocan lo ‘infantil inextinguible’ de la angustia, descubierto por Sigmund Freud, cuando se atreve a penetrar la comarca de la estética y teoriza lo Unheimlich como lo extraño que invade lo familiar. Un afecto estético. Esta tesis muestra que el cine es Unheimlich pues acosa la real...

  4. La inquietante extra??eza en el cine

    OpenAIRE

    Antelo, Marcela

    2015-01-01

    La inquietante extra??eza en el cine parte de considerar la experiencia cinematogr??fica como un acontecimiento de la sensibilidad. La sala oscura proporciona una intimidad con extra??os, y el silencio y la oscuridad evocan lo ???infantil inextinguible??? de la angustia, descubierto por Sigmund Freud, cuando se atreve a penetrar la comarca de la est??tica y teoriza lo Unheimlich como lo extra??o que invade lo familiar. Un afecto est??tico. Esta tesis muestra que el cine es Unheimlich pues aco...

  5. Finite temperature Casimir effect in spacetime with extra compactified dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Teo, L.P. [Faculty of Information Technology, Multimedia University, Jalan Multimedia, Cyberjaya 63100, Selangor Darul Ehsan (Malaysia)], E-mail: lpteo@mmu.edu.my

    2009-02-16

    In this Letter, we derive the explicit exact formulas for the finite temperature Casimir force acting on a pair of parallel plates in the presence of extra compactified dimensions within the framework of Kaluza-Klein theory. Using the piston analysis, we show that at any temperature, the Casimir force due to massless scalar field with Dirichlet boundary conditions on the plates is always attractive and the effect of extra dimensions becomes stronger when the size or number of the extra dimensions increases. These properties are not affected by the explicit geometry and topology of the Kaluza-Klein space.

  6. A new energy source originating from extra dimensions

    Institute of Scientific and Technical Information of China (English)

    Tao Bi-Xiu; Ji Shi-Yin; Li Fang-Qiong

    2004-01-01

    In this work the Einstein gravitational field equations and the Lichnerowicz boundary formalism in the extra dimensions are used to build up our black hole model from 6-dimensional space-time. From the internal stress-energy tensor the solutions with energy levels and semiclassical space-quantization are obtained, which combines with only one metric condition outside the defect. We show a new type of energy source, which originates from extra dimensions. A part of the energy source of quasi-stellar object (QSO) maybe come from extra dimensions in that way. The theoretical arithmetic upper limit is identical to that of the output energy of QSO.

  7. Different types of inks having certain medicolegal importance: Deciphering the faded and physically erased handwriting

    Directory of Open Access Journals (Sweden)

    Manal Abd-ElAziz Abd-ElZaher

    2014-06-01

    Full Text Available Disappearing ink is a type of ink which could be used to forge documents as it will fade away without any trace within 40–65 h. Erasable ink is another type of ink easily removed by certain rubbers incorporated in each pen. Both types of inks were applied separately on different types of papers (checks, standard white foolscap, and plain white A4 paper. For vanishing ink, it was observed visually in the first 6 h and then every 6 h. It was found that the vanishing ink disappeared completely within 2 h on checks, 36 h on standard white foolscap paper, and 40 h on plain white A4 paper. For erasable ink, the written strokes were manipulated manually using the incorporated eraser. Deciphering the faded writing failed by the conventional methods, but oblique light can reveal the indentation marks. The faded writing became visible when treated with weak alkaline (NaOH solutions. Erasable ink was deciphered with the aid of infra-red radiation combined with VSC-6000 as clear white traces against red fluorescence. It was concluded that the use of a weak (NaOH solution is an effective method for revealing the faded writing, and the infra-red illumination is also effective.

  8. Extra Dimensions at the Weak Scale and Deviations from Newtonian Gravity

    CERN Document Server

    Chacko, Z; Chacko, Zackaria; Perazzi, Elena

    2003-01-01

    We consider theories in which the Standard Model gauge fields propagate in extra dimensions whose size is around the electroweak scale. The Standard Model quarks and leptons may either be localized to a brane or propagate in the bulk. This class of theories includes models of Scherk-Schwarz supersymmetry breaking and universal extra dimensions. We consider the problem of stabilizing the volume of the extra dimensions. We find that for a large class of stabilization mechanisms the field which corresponds to fluctuations of the volume remains light even after stabilization, and has a mass in the $10^{-3}$ eV range. In particular this is the case if stabilization does not involve dynamics at scales larger than the cutoff of the higher dimensional Standard Model, and if the effective theory below the compactification scale is four dimensional. The mass of this field is protected against large radiative corrections by the general covariance of the higher dimensional theory and by the weakness of its couplings, whi...

  9. Kuu plaat : Cardigans "Super Extra Gravity". Plaadid kauplusest Lasering

    Index Scriptorium Estoniae

    2005-01-01

    Heliplaatidest : Cardigans "Super Extra Gravity", Metsatöll "Terast mis hangund me hinge 10218", Ursula "Annamemenõu", Critikal "Chapter One ehk Teine Maitse", Robbie Williams "Intensive Care", Depeche Mode "Playing the Angel"

  10. Extra limit counts for southern sea otter 2016

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The GIS shapefile "Extra limit counts of southern sea otters 2016" is a point layer representing the locations of sea otter sightings that fall outside the...

  11. Probing large extra dimensions with IceCube

    Energy Technology Data Exchange (ETDEWEB)

    Esmaili, Arman [Institute of Convergence Fundamental Studies and School of Liberal Arts, Seoul National University of Science and Technology, Seoul 139-743 (Korea, Republic of); Peres, O.L.G.; Tabrizi, Zahra, E-mail: arman@ipm.ir, E-mail: orlando@ifi.unicamp.br, E-mail: tabrizi.physics@ipm.ir [Instituto de Física Gleb Wataghin - UNICAMP, 13083-859, Campinas, SP (Brazil)

    2014-12-01

    In models with Large Extra Dimensions the smallness of neutrino masses can be naturally explained by introducing gauge singlet fermions which propagate in the bulk. The Kaluza-Klein modes of these fermions appear as towers of sterile neutrino states on the brane. We study the phenomenological consequences of this picture for the high energy atmospheric neutrinos. For this purpose we construct a detailed equivalence between a model with large extra dimensions and a (3+n) scenario consisting of three active and n extra sterile neutrino states, which provides a clear intuitive understanding of Kaluza-Klein modes. Finally, we analyze the collected data of high energy atmospheric neutrinos by IceCube experiment and obtain bounds on the radius of extra dimensions.

  12. Kuu plaat : Cardigans "Super Extra Gravity". Plaadid kauplusest Lasering

    Index Scriptorium Estoniae

    2005-01-01

    Heliplaatidest : Cardigans "Super Extra Gravity", Metsatöll "Terast mis hangund me hinge 10218", Ursula "Annamemenõu", Critikal "Chapter One ehk Teine Maitse", Robbie Williams "Intensive Care", Depeche Mode "Playing the Angel"

  13. ExTrA: Exoplanets in Transit and their Atmospheres

    CERN Document Server

    Bonfils, X; Jocou, L; Wunsche, A; Kern, P; Delboulbé, A; Delfosse, X; Feautrier, P; Forveille, T; Gluck, L; Lafrasse, S; Magnard, Y; Maurel, D; Moulin, T; Murgas, F; Rabou, P; Rochat, S; Roux, A; Stadler, E

    2015-01-01

    The ExTrA facility, located at La Silla observatory, will consist of a near-infrared multi-object spectrograph fed by three 60-cm telescopes. ExTrA will add the spectroscopic resolution to the traditional differential photometry method. This shall enable the fine correction of color-dependent systematics that would otherwise hinder ground-based observations. With both this novel method and an infrared-enabled efficiency, ExTrA aims to find transiting telluric planets orbiting in the habitable zone of bright nearby M dwarfs. It shall have the versatility to do so by running its own independent survey and also by concurrently following-up on the space candidates unveiled by K2 and TESS. The exoplanets detected by ExTrA will be amenable to atmospheric characterisation with VLTs, JWST, and ELTs and could give our first peek into an exo-life laboratory.

  14. Maria Montessori (1870-1952): Women's emancipation, pedagogy and extra verbal communication.

    Science.gov (United States)

    Cascella, Marco

    2015-05-01

    Maria Montessori is one of the most well-known women in Italian history. Although she was the first woman who graduated in medicine in Italy, she is mostly known as an educator. Her teaching method--the Montessori Method- is still used worldwide--Because she could not speak English during the imprisonment in India, there was a big obstacle for her communication with children. However, the need to adopt a non-verbal communication, led her to a sensational discovery: children use an innate and universal language. This language, made of gestures and mimic, is called extra verbal communication.

  15. The detection of extra-terrestrial life and the consequences for science and society.

    Science.gov (United States)

    Dominik, Martin; Zarnecki, John C

    2011-02-13

    Astronomers are now able to detect planets orbiting stars other than the Sun where life may exist, and living generations could see the signatures of extra-terrestrial life being detected. Should it turn out that we are not alone in the Universe, it will fundamentally affect how humanity understands itself--and we need to be prepared for the consequences. A Discussion Meeting held at the Royal Society in London, 6-9 Carlton House Terrace, on 25-26 January 2010, addressed not only the scientific but also the societal agenda, with presentations covering a large diversity of topics.

  16. Multiple extra macular branch retinal vein occlusions in hyperhomocysteinemia

    Directory of Open Access Journals (Sweden)

    Abhijit Diwakar Gore

    2014-01-01

    Full Text Available Hyperhomocysteinemia is a well-known modifiable risk factor for thromboembolism. Retinal vascular occlusion in patients having hyperhomocysteinemia is a known entity, particularly in young patients. However, multiple extra macular branch retinal vein occlusion (BRVO is a rare condition, which can be a presentation of this disease. We present a patient who had multiple extra macular BRVO; on complete systemic workup, he was found to have raised homocysteine levels.

  17. Extra-aortic implantable counterpulsation pump in chronic heart failure.

    Science.gov (United States)

    Mitnovetski, Sergei; Almeida, Aubrey A; Barr, Althea; Peters, William S; Milsom, F Paget; Ho, Betty; Smith, Julian A

    2008-06-01

    Extra-aortic counterpulsation for the management of chronic heart failure is a novel approach. We report the use of an extra-aortic implantable counterpulsation pump in the management of a 73-year-old patient with severe heart failure refractory to medical therapy. The implantable counterpulsation pump prolonged his life and greatly improved its quality. The patient lived almost 7 months after the implantation of the device and died of septic complications secondary to gas line infection.

  18. Extra-Abdominal Desmoid Tumors Associated with Familial Adenomatous Polyposis

    Directory of Open Access Journals (Sweden)

    George T. Calvert

    2012-01-01

    Full Text Available Extra-abdominal desmoid tumors are a significant cause of morbidity in patients with familial adenomatous polyposis syndrome. Understanding of the basic biology and natural history of these tumors has increased substantially over the past decade. Accordingly, medical and surgical management of desmoid tumors has also evolved. This paper analyzes recent evidence pertaining to the epidemiology, molecular biology, histopathology, screening, and treatment of extra-abdominal desmoid tumors associated with familial adenomatous polyposis syndrome.

  19. Kaluza-Klein Theory without Extra Dimensions: Curved Clifford Space

    CERN Document Server

    Pavsic, M

    2005-01-01

    A theory in which 16-dimensional curved Clifford space (C-space) provides realization of Kaluza-Klein theory is investigated. No extra dimensions of spacetime are needed: "extra dimensions" are in C-space. It is shown that the covariant Dirac equation in C-space contains Yang-Mills fields of the U(1)xSU(2)xSU(3) group as parts of the generalized spin connection of the C-space.

  20. [On mistakes in contemporary literatures of extra points in China].

    Science.gov (United States)

    Huang, Long-Xiang; Huang, You-Min

    2013-06-01

    Contemporary literatures which are taken as the base of literature study of extra points are insufficient and lack of reliability. The foundation of study is very weak. Based on abundant firsthand materials, analyses are made on the major problems of confounded names and locations, unclear quotation and source of reference in the study of contemporary literatures of extra points. Meanwhile, methods and way of thinking for solving the above mentioned problems are discussed in this article as well.

  1. Extra-pair mating and evolution of cooperative neighbourhoods.

    Directory of Open Access Journals (Sweden)

    Sigrunn Eliassen

    Full Text Available A striking but unexplained pattern in biology is the promiscuous mating behaviour in socially monogamous species. Although females commonly solicit extra-pair copulations, the adaptive reason has remained elusive. We use evolutionary modelling of breeding ecology to show that females benefit because extra-pair paternity incentivizes males to shift focus from a single brood towards the entire neighbourhood, as they are likely to have offspring there. Male-male cooperation towards public goods and dear enemy effects of reduced territorial aggression evolve from selfish interests, and lead to safer and more productive neighbourhoods. The mechanism provides adaptive explanations for the common empirical observations that females engage in extra-pair copulations, that neighbours dominate as extra-pair sires, and that extra-pair mating correlates with predation mortality and breeding density. The models predict cooperative behaviours at breeding sites where males cooperate more towards public goods than females. Where maternity certainty makes females care for offspring at home, paternity uncertainty and a potential for offspring in several broods make males invest in communal benefits and public goods. The models further predict that benefits of extra-pair mating affect whole nests or neighbourhoods, and that cuckolding males are often cuckolded themselves. Derived from ecological mechanisms, these new perspectives point towards the evolution of sociality in birds, with relevance also for mammals and primates including humans.

  2. Generalized Uncertainty Principle in the Presence of Extra Dimensions

    Institute of Scientific and Technical Information of China (English)

    MU Ben-Bong; WU Hou-Wen; YANG Hai-Tang

    2011-01-01

    @@ We argue that in the generalized uncertainty principle(GUP)model,the parameter β0 whose square root,minimal measurable length and extra dimensions are both suggested by quantum gravity theories,we investigate the models based on the GUP and one extra dimension,compactified with radius p.We obtain an inspiring quantum mechanics scale.We also estimate the application range of the GUP model.It turns out that the minimum measurable length is exactly the compactification radius of the extra dimension.%We argue that in the generalized uncertainty principle (GUP) model, the parameter 0o whose square root, multiplied by Planck length tv, approximates the minimum measurable distance, varies with energy scales. Since the minimal measurable length and extra dimensions are both suggested by quantum gravity theories, we investigate the models based on the GUP and one extra dimension, compactified with radius p. We obtain an inspiring relation βolp/p ~ 0(1). This relation is also consistent with the predictions at Planck scale and the usual quantum mechanics scale. We also estimate the application range of the GUP model. It turns out that the minimum measurable length is exactly the compactiScation radius of the extra dimension.

  3. Extra-pair mating and evolution of cooperative neighbourhoods.

    Science.gov (United States)

    Eliassen, Sigrunn; Jørgensen, Christian

    2014-01-01

    A striking but unexplained pattern in biology is the promiscuous mating behaviour in socially monogamous species. Although females commonly solicit extra-pair copulations, the adaptive reason has remained elusive. We use evolutionary modelling of breeding ecology to show that females benefit because extra-pair paternity incentivizes males to shift focus from a single brood towards the entire neighbourhood, as they are likely to have offspring there. Male-male cooperation towards public goods and dear enemy effects of reduced territorial aggression evolve from selfish interests, and lead to safer and more productive neighbourhoods. The mechanism provides adaptive explanations for the common empirical observations that females engage in extra-pair copulations, that neighbours dominate as extra-pair sires, and that extra-pair mating correlates with predation mortality and breeding density. The models predict cooperative behaviours at breeding sites where males cooperate more towards public goods than females. Where maternity certainty makes females care for offspring at home, paternity uncertainty and a potential for offspring in several broods make males invest in communal benefits and public goods. The models further predict that benefits of extra-pair mating affect whole nests or neighbourhoods, and that cuckolding males are often cuckolded themselves. Derived from ecological mechanisms, these new perspectives point towards the evolution of sociality in birds, with relevance also for mammals and primates including humans.

  4. The use of ICS/LABA (extra-fine and non-extra-fine in elderly asthmatics

    Directory of Open Access Journals (Sweden)

    Benfante A

    2016-10-01

    Full Text Available Alida Benfante, Marco Basile, Salvatore Battaglia, Mario Spatafora, Nicola Scichilone Biomedical Department of Internal and Specialist Medicine, University of Palermo, Palermo, Italy Abstract: Age represents an exclusion criterion in randomized clinical trials designed to test the efficacy and safety of inhaled drugs in asthma. As a consequence, data on efficacy and safety of inhaled corticosteroid (ICS and long-acting ß2 agonist (LABA combinations in elderly asthmatics are scanty. Older age is associated with an increased proportion of comorbid conditions; in addition, all organ functions undergo a process of senescence, thus reducing their ability to metabolize the agents. Overall, these age-associated conditions may variably, and often unpredictably, affect the metabolism and excretion of respiratory drugs. However, pharmacological treatment of asthma does not follow specific recommendations in the elderly. In the elderly, the ICS/LABA combinations may carry an increased risk of local indesiderable effects, primarily due to the lack of coordination between activation of the device and inhalation, and systemic adverse events, mainly due to the greater amount of active drug that is available because of the age-associated changes in organ functions as well as drug-to-drug and drug-to-concomitant disease interactions. The extra-fine formulations of ICSs/LABAs, which allow for a more favorable drug deposition in the lungs at a reduced dose, may contribute to overcome this issue. This review revises the efficacy and safety of treatment with ICSs/LABAs, focusing on the main pharmacodynamic and pharmacokinetic properties of the drugs and highlighting the potential risks in the elderly asthmatic population. Keywords: aging, comorbidity, lung function, inhaled corticosteroids, long-acting ß2 agonists, asthma treatment

  5. NASA Space Astronomy Update 6: Unconventional Windows on the Universe

    Science.gov (United States)

    1992-01-01

    Professor Stu Bowyer (University of California at Berkeley) explains the Extreme Ultraviolet Explorer and its telescope in this video. Both instrument and satellite are kept in perfect working condition. The satellite picks up extra galactic objects outside our galaxy.

  6. Deciphering the complete mitochondrial genome and phylogeny of the extinct cave bear in the Paleolithic painted cave of Chauvet

    NARCIS (Netherlands)

    Bon, Céline; Caudy, Nicolas; De Dieuleveult, Maud; Fosse, Philippe; Philippe, Michel; Maksud, Frédéric; Beraud-Colomb, Éliane; Bouzaid, Eric; Kefi, Rym; Laugier, Christelle; Rousseau, Bernard; Casane, Didier; Van Der Plicht, Johannes; Elalouf, Jean-Marc

    2008-01-01

    Retrieving a large amount of genetic information from extinct species was demonstrated feasible, but complete mitochondrial genome sequences have only been deciphered for the moa, a bird that became extinct a few hundred years ago, and for Pleistocene species, such as the woolly mammoth and the mast

  7. Deciphering the complete mitochondrial genome and phylogeny of the extinct cave bear in the Paleolithic painted cave of Chauvet

    NARCIS (Netherlands)

    Bon, Céline; Caudy, Nicolas; De Dieuleveult, Maud; Fosse, Philippe; Philippe, Michel; Maksud, Frédéric; Beraud-Colomb, Éliane; Bouzaid, Eric; Kefi, Rym; Laugier, Christelle; Rousseau, Bernard; Casane, Didier; Van Der Plicht, Johannes; Elalouf, Jean-Marc

    2008-01-01

    Retrieving a large amount of genetic information from extinct species was demonstrated feasible, but complete mitochondrial genome sequences have only been deciphered for the moa, a bird that became extinct a few hundred years ago, and for Pleistocene species, such as the woolly mammoth and the mast

  8. Four Versions of the Christus by the Massys: Deciphering the Meaning of the Letters

    Directory of Open Access Journals (Sweden)

    Vicente Jara Vera

    2017-02-01

    Full Text Available The Flemish painters Quentin Massys and his son Jan Massys appear to be the authors of four works with a very similar motif, the bust of Jesus Christ. These canvasses can be found in different locations today: the Prado Museum in Madrid (Spain, the RKD Netherlands Institute for Art History of The Hague (Netherlands, the Kunstmuseum Winterthur (Switzerland, and another one in a private collection. Written on the edge of the robe around the neck, these canvasses display a series of Hebrew or pseudo-Hebrew letters. We offer the complete solution deciphered, until today incomplete, for three of them, with a very similar letter sequence. Finally, we resolve completely one of the canvasses, which, until today, had no known solution.

  9. Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect

    Directory of Open Access Journals (Sweden)

    Ilić Marija

    2015-12-01

    Full Text Available With the increased reliance on in vitro dissolution testing as an indicator of in vivo drug behavior and the trend towards the in silico modeling of dosage form performance, the need for bioperformance dissolution methodology development has been enhanced. Determination of the in vivo drug delivery profile is essential for the bioperformance dissolution test development and in vitro/in vivo correlation modeling, as well as the understanding of absorption mechanisms. The aim of this study was to compare different methods in terms of their usefulness and applicability in deciphering in vivo delivery of nifedipine administered in modified release dosage forms. A detailed survey of publications on nifedipine pharmacokinetics was done and used to identify the magnitude of food effect. In vitro dissolution testing was performed under various experimental conditions. Obtained results indicate the potential for using the developed in silico model coupled with discriminative in vitro dissolution data for identification of the in vivo drug product behavior

  10. A 'tool box' for deciphering neuronal circuits in the developing chick spinal cord.

    Science.gov (United States)

    Hadas, Yoav; Etlin, Alex; Falk, Haya; Avraham, Oshri; Kobiler, Oren; Panet, Amos; Lev-Tov, Aharon; Klar, Avihu

    2014-10-29

    The genetic dissection of spinal circuits is an essential new means for understanding the neural basis of mammalian behavior. Molecular targeting of specific neuronal populations, a key instrument in the genetic dissection of neuronal circuits in the mouse model, is a complex and time-demanding process. Here we present a circuit-deciphering 'tool box' for fast, reliable and cheap genetic targeting of neuronal circuits in the developing spinal cord of the chick. We demonstrate targeting of motoneurons and spinal interneurons, mapping of axonal trajectories and synaptic targeting in both single and populations of spinal interneurons, and viral vector-mediated labeling of pre-motoneurons. We also demonstrate fluorescent imaging of the activity pattern of defined spinal neurons during rhythmic motor behavior, and assess the role of channel rhodopsin-targeted population of interneurons in rhythmic behavior using specific photoactivation.

  11. Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines.

    Science.gov (United States)

    Wilson, Robert; McGuire, Christina; Mohun, Timothy

    2016-01-01

    The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo development and survival. The project uses a combination of comprehensive high resolution 3D imaging and tissue histology to identify abnormalities in embryo and placental structures of embryonic lethal lines. The image data we have collected and the phenotypes scored are freely available through the project website (http://dmdd.org.uk). In this article we describe the web interface to the images that allows the embryo data to be viewed at full resolution in different planes, discuss how to search the database for a phenotype, and our approach to organising the data for an embryo and a mutant line so it is easy to comprehend and intuitive to navigate.

  12. Deciphering the evolutionary interplay between subgenomes following polyploidy: A paleogenomics approach in grasses.

    Science.gov (United States)

    Salse, Jérôme

    2016-07-01

    How did plant species emerge from their most recent common ancestors (MRCAs) 250 million years ago? Modern plant genomes help to address such key questions in unveiling precise species genealogies. The field of paleogenomics is undergoing a paradigm shift for investigating species evolution from the study of ancestral genomes from extinct species to deciphering the evolutionary forces (in terms of duplication, fusion, fission, deletion, and translocation) that drove present-day plant diversity (in terms of chromosome/gene number and genome size). In this review, inferred ancestral karyotype genomes are shown to be powerful tools to (1) unravel the past history of extant species by recovering the variations of ancestral genomic compartments and (2) accelerate translational research by facilitating the transfer of genomic information from model systems to species of agronomic interest.

  13. DECIPHERING THE FINEST IMPRINT OF GLACIAL EROSION: OBJECTIVE ANALYSIS OF STRIAE PATTERNS ON BEDROCK

    Directory of Open Access Journals (Sweden)

    Piet Stroeven

    2011-05-01

    Full Text Available The aim of this study is to compare the efficiency of different mathematical and statistical geometrical methods applied to characterise the orientation distribution of striae on bedrock for deciphering the finest imprint of glacial erosion. The involved methods include automatic image analysis techniques of Fast Fourier Transform (FFT, and the experimental investigations by means of Saltikov's directed secants analysis (rose of intersection densities, applied to digital and analogue images of the striae pattern, respectively. In addition, the experimental data were compared with the modelling results made on the basis of Underwood's concept of linear systems in a plane. The experimental and modelling approaches in the framework of stereology yield consistent results. These results reveal that stereological methods allow a reliable and efficient delineation of different families of glacial striae from a complex record imprinted in bedrock.

  14. Metabolomics to Decipher the Chemical Defense of Cereals against Fusarium graminearum and Deoxynivalenol Accumulation

    Science.gov (United States)

    Gauthier, Léa; Atanasova-Penichon, Vessela; Chéreau, Sylvain; Richard-Forget, Florence

    2015-01-01

    Fusarium graminearum is the causal agent of Fusarium head blight (FHB) and Gibberella ear rot (GER), two devastating diseases of wheat, barley, and maize. Furthermore, F. graminearum species can produce type B trichothecene mycotoxins that accumulate in grains. Use of FHB and GER resistant cultivars is one of the most promising strategies to reduce damage induced by F. graminearum. Combined with genetic approaches, metabolomic ones can provide powerful opportunities for plant breeding through the identification of resistant biomarker metabolites which have the advantage of integrating the genetic background and the influence of the environment. In the past decade, several metabolomics attempts have been made to decipher the chemical defense that cereals employ to counteract F. graminearum. By covering the major classes of metabolites that have been highlighted and addressing their potential role, this review demonstrates the complex and integrated network of events that cereals can orchestrate to resist to F. graminearum. PMID:26492237

  15. Deciphering the Physical Basis of Biomineralization through Investigations of Nanoscale Growth Processes

    Science.gov (United States)

    Dove, P. M.; Davis, K. J.; De Yoreo, J. J.; Orme, C. A.

    2001-12-01

    Microbes and higher organisms direct the formation of complex structures in controlled biomineralization. Using biologically mediated crystallization strategies that have evolved over millenia, organisms have developed the ability to produce nanophase structures as single crystals and composite materials with remarkable properties that fulfill specific functional needs. Modern organisms, as well as those found in the sediment and rock records, chronicle Nature's ability to synthesize sophisticated nanostructures. Although biomineral compositions and their morphologies are windows to interpreting environments of prosperity and decline, most current interpretations lack an understanding of fundamental processes. Hence, the physical basis of biological mineralization continues as one of Nature's best kept secrets. Recently, the biomineralization processes of marine microorganisms have emerged as particularly important owing to the use of biomineral products as paleoclimate indicators. Besides providing critical information on crystal growth history, the minor and trace elements found in these materials also behave as impurities to regulate their properties and formation rates. Using integrated approaches, we are investigating the kinetics and thermodynamics of calcite growth to decipher mechanisms of biomineral formation. Our focus is to link molecular interactions with surface processes and nanoscale controls on crystal morphology. The molecular-scale structure of the crystalline interface is a critical growth determinant, especially when considering nanocrystalline phases. By combining in situ AFM studies of growth that use carefully characterized solution chemistries with molecular modeling and surface spectroscopic investigations, we couple observations of nanoscale growth mechanisms with quantitative kinetic and thermodynamic information. This approach is showing how key inorganic growth impurities, Mg2+ and Sr2+, affect mineralization through complex ion

  16. Comprehensive Determination of Prostate Tumor ETS Gene Status in Clinical Samples Using the CLIA Decipher Assay.

    Science.gov (United States)

    Torres, Alba; Alshalalfa, Mohammed; Tomlins, Scott A; Erho, Nicholas; Gibb, Ewan A; Chelliserry, Jijumon; Lim, Lony; Lam, Lucia L C; Faraj, Sheila F; Bezerra, Stephania M; Davicioni, Elai; Yousefi, Kasra; Ross, Ashley E; Netto, George J; Schaeffer, Edward M; Lotan, Tamara L

    2017-05-01

    ETS family gene fusions are common in prostate cancer and molecularly define a tumor subset. ERG is the most commonly rearranged, leading to its overexpression, followed by ETV1, ETV4, and ETV5, and these alterations are generally mutually exclusive. We validated the Decipher prostate cancer assay to detect ETS alterations in a Clinical Laboratory Improvement Amendments-accredited laboratory. Benchmarking against ERG immunohistochemistry and ETV1/4/5 RNA in situ hybridization, we examined the accuracy, precision, and reproducibility of gene expression ETS models using formalin-fixed, paraffin-embedded samples. The m-ERG model achieved an area under curve of 95%, with 93% sensitivity and 98% specificity to predict ERG immunohistochemistry status. The m-ETV1, -ETV4, and -ETV5 models achieved areas under curve of 98%, 88%, and 99%, respectively. The models had 100% robustness for ETS status, and scores were highly correlated across sample replicates. Models predicted 41.5% of a prospective radical prostatectomy cohort (n = 4036) to be ERG(+), 6.3% ETV1(+), 1% ETV4(+), and 0.4% ETV5(+). Of prostate tumor biopsy samples (n = 509), 41.2% were ERG(+), 8.6% ETV1(+), 0.4% ETV4(+), and none ETV5(+). Higher Decipher risk status tumors were more likely to be ETS(+) (ERG or ETV1/4/5) in the radical prostatectomy and the biopsy cohorts (P ETS status prediction models for molecular classification of prostate tumors. Copyright © 2017 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  17. Deciphering evolutionary strata on plant sex chromosomes and fungal mating-type chromosomes through compositional segmentation.

    Science.gov (United States)

    Pandey, Ravi S; Azad, Rajeev K

    2016-03-01

    Sex chromosomes have evolved from a pair of homologous autosomes which differentiated into sex determination systems, such as XY or ZW system, as a consequence of successive recombination suppression between the gametologous chromosomes. Identifying the regions of recombination suppression, namely, the "evolutionary strata", is central to understanding the history and dynamics of sex chromosome evolution. Evolution of sex chromosomes as a consequence of serial recombination suppressions is well-studied for mammals and birds, but not for plants, although 48 dioecious plants have already been reported. Only two plants Silene latifolia and papaya have been studied until now for the presence of evolutionary strata on their X chromosomes, made possible by the sequencing of sex-linked genes on both the X and Y chromosomes, which is a requirement of all current methods that determine stratum structure based on the comparison of gametologous sex chromosomes. To circumvent this limitation and detect strata even if only the sequence of sex chromosome in the homogametic sex (i.e. X or Z chromosome) is available, we have developed an integrated segmentation and clustering method. In application to gene sequences on the papaya X chromosome and protein-coding sequences on the S. latifolia X chromosome, our method could decipher all known evolutionary strata, as reported by previous studies. Our method, after validating on known strata on the papaya and S. latifolia X chromosome, was applied to the chromosome 19 of Populus trichocarpa, an incipient sex chromosome, deciphering two, yet unknown, evolutionary strata. In addition, we applied this approach to the recently sequenced sex chromosome V of the brown alga Ectocarpus sp. that has a haploid sex determination system (UV system) recovering the sex determining and pseudoautosomal regions, and then to the mating-type chromosomes of an anther-smut fungus Microbotryum lychnidis-dioicae predicting five strata in the non

  18. Deciphering Late-Pleistocence landscape evolution: linking proxies by combining pedo-stratigraphy and luminescence dating

    Science.gov (United States)

    Kreutzer, Sebastian; Meszner, Sascha; Faust, Dominik; Fuchs, Markus

    2014-05-01

    Interpreting former landscape evolution asks for understanding the processes that sculpt such landforms by means of deciphering complex systems. For reconstructing terrestrial Quaternary environments based on loess archives this might be considered, at least, as a three step process: (1) Identifying valuable records in appropriate morphological positions in a previously defined research area, (2) analysing the profiles by field work and laboratory methods and finally (3) linking the previously considered pseudo-isolated systems to set up a comprehensive picture. Especially the first and the last step might bring some pitfalls, as it is tempting to specify single records as pseudo-isolated, closed systems. They might be, with regard to their preservation in their specific morphological position, but in fact they are part of a complex, open system. Between 2008 and 2013, Late-Pleistocene loess archives in Saxony have been intensively investigated by field and laboratory methods. Linking pedo- and luminescence dating based chronostratigraphies, a composite profile for the entire Saxonian Loess Region has been established. With this, at least, two-fold approach we tried to avoid misinterpretations that might appear when focussing on one standard profile in an open morphological system. Our contribution focuses on this multi-proxy approach to decipher the Late-Pleistocene landscape evolution in the Saxonian Loess Region. Highlighting the challenges and advantages of combining different methods, we believe that (1) this multi-proxy approach is without alternative, (2) the combination of different profiles may simplify the more complex reality, but it may be a useful generalisation to understand and reveal the stratigraphical significance of the landscape evolution in this region.

  19. Deciphering Egyptian Hieroglyphs: Towards a New Strategy for Navigation in Museums.

    Science.gov (United States)

    Duque-Domingo, Jaime; Herrera, Pedro Javier; Valero, Enrique; Cerrada, Carlos

    2017-03-14

    This work presents a novel strategy to decipher fragments of Egyptian cartouches identifying the hieroglyphs of which they are composed. A cartouche is a drawing, usually inside an oval, that encloses a group of hieroglyphs representing the name of a monarch. Aiming to identify these drawings, the proposed method is based on several techniques frequently used in computer vision and consists of three main stages: first, a picture of the cartouche is taken as input and its contour is localized. In the second stage, each hieroglyph is individually extracted and identified. Finally, the cartouche is interpreted: the sequence of the hieroglyphs is established according to a previously generated benchmark. This sequence corresponds to the name of the king. Although this method was initially conceived to deal with both high and low relief writing in stone, it can be also applied to painted hieroglyphs. This approach is not affected by variable lighting conditions, or the intensity and the completeness of the objects. This proposal has been tested on images obtained from the Abydos King List and other Egyptian monuments and archaeological excavations. The promising results give new possibilities to recognize hieroglyphs, opening a new way to decipher longer texts and inscriptions, being particularly useful in museums and Egyptian environments. Additionally, devices used for acquiring visual information from cartouches (i.e., smartphones), can be part of a navigation system for museums where users are located in indoor environments by means of the combination of WiFi Positioning Systems (WPS) and depth cameras, as unveiled at the end of the document.

  20. Deciphering Egyptian Hieroglyphs: Towards a New Strategy for Navigation in Museums

    Directory of Open Access Journals (Sweden)

    Jaime Duque-Domingo

    2017-03-01

    Full Text Available This work presents a novel strategy to decipher fragments of Egyptian cartouches identifying the hieroglyphs of which they are composed. A cartouche is a drawing, usually inside an oval, that encloses a group of hieroglyphs representing the name of a monarch. Aiming to identify these drawings, the proposed method is based on several techniques frequently used in computer vision and consists of three main stages: first, a picture of the cartouche is taken as input and its contour is localized. In the second stage, each hieroglyph is individually extracted and identified. Finally, the cartouche is interpreted: the sequence of the hieroglyphs is established according to a previously generated benchmark. This sequence corresponds to the name of the king. Although this method was initially conceived to deal with both high and low relief writing in stone, it can be also applied to painted hieroglyphs. This approach is not affected by variable lighting conditions, or the intensity and the completeness of the objects. This proposal has been tested on images obtained from the Abydos King List and other Egyptian monuments and archaeological excavations. The promising results give new possibilities to recognize hieroglyphs, opening a new way to decipher longer texts and inscriptions, being particularly useful in museums and Egyptian environments. Additionally, devices used for acquiring visual information from cartouches (i.e., smartphones, can be part of a navigation system for museums where users are located in indoor environments by means of the combination of WiFi Positioning Systems (WPS and depth cameras, as unveiled at the end of the document.

  1. Realistic Field Theories on Submanifolds of Compact Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Mirabelli, E.

    2005-04-05

    In this thesis, they study various physical models which assume the existence of spatial dimensions beyond the familiar three. While everyday observation suggests only three dimensions, there is no shortage of potential explanations for how extra dimensions could have escaped detection for so long. For instance, the extra dimensions could be compact, curled into a microscopic volume so that you can never move far in the extra dimensions without ending up back where you started. Or, the elements of everyday experience could be trapped on a three-dimensional membrane floating in a higher dimensions space. The models studied in this thesis each use both of these mechanisms in tandem, with electrons, photons, quarks, and the like being confined to a three-dimensional membrane that sits in a space with compact extra dimensions. Gravitons (and perhaps other new types of particles) could travel beyond the three-dimensional membrane, so they can feel the effects of the higher-dimensional space, but because the extra dimensions are compactified on a small scale, the effects are subtle.

  2. Conquering the Mesoscale of Africa's Landscapes: deciphering the Genomic Record of Individuating Landforms with Geoecodynamics

    Science.gov (United States)

    Cotterill, Fenton P. D.

    2016-04-01

    In the framework of Earth System Science, landscapes are the templates structuring the biosphere: the membranes interfacing between exosphere and geosphere. The hosts of earth surface processes, in their dynamics and complexity, landscapes hold a pivotal position in the evolving earth system - not least in their archives of Earth history. Their landforms document impacts of formative events originating in extra-terrestrial, geological and climatic processes. Nevertheless, major challenges to reconstruct dynamics at this interface between geosphere and exosphere hamper research efforts. Events at the mesoscale over evolutionary timescales are an important reason for why the academic schools of mega- versus process geomorphology persist (see Summerfield MA 2005. Trans. Inst. Brit Geogr NS, 30, 402-415). Austere limits on what their respective methods can reveal in mesoscale phenomena face several problems (besides costs of sampling and analyses). One, surviving landforms often lack the requisite minerals (e.g. of volcanic events). Second, the spatial resolution of orthodox methods (e.g. thermochronology) cannot resolve mesoscale patterns. Third, the surface dating tools with superb spatial precision have finitee temporal limits (Luminescence-Dating and Cosmogenic Isotopes). Fourth, and by no means least, the cumulative impact of earth surface processes has overwritten and/or eroded physical evidence of earlier formative events. (This problem is exemplified in tropical landscapes where deep, pervasive bioturbation is the dominant earth surface process!) The cumulative outcome of these inherent turnovers of landscapes has shaped the inherent emptiness of the Rock Record, which sets absolute limits on its archives (Ager D 1993. The Nature of the Stratigraphical Record; Miall AD 2015. in: Strata and Time: Probing the Gaps in Our Understanding. Geological Society, London, Special Publications, 404, http://dx.doi.org/10.1144/SP404.4). These limitations on mesoscale

  3. The Role of Extra-Credit Assignments in the Teaching of World Languages

    Science.gov (United States)

    Alley, David

    2011-01-01

    The granting of extra credit is a hotly debated topic in all fields of education. Teachers are reluctant to offer extra credit for fear of inflating grades, but students are persistent in their demands for extra-credit points to which they have become accustomed. This article considers extra-credit assignments in the teaching of world languages.…

  4. Constraints on Large Extra Dimensions from the MINOS Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Adamson, P.; et al.

    2016-12-16

    We report new constraints on the size of large extra dimensions from data collected by the MINOS experiment between 2005 and 2012. Our analysis employs a model in which sterile neutrinos arise as Kaluza-Klein states in large extra dimensions and thus modify the neutrino oscillation probabilities due to mixing between active and sterile neutrino states. Using Fermilab’s Neutrinos at the Main Injector beam exposure of 10.56×1020 protons on target, we combine muon neutrino charged current and neutral current data sets from the Near and Far Detectors and observe no evidence for deviations from standard three-flavor neutrino oscillations. The ratios of reconstructed energy spectra in the two detectors constrain the size of large extra dimensions to be smaller than 0.45 μm at 90% C.L. in the limit of a vanishing lightest active neutrino mass. Stronger limits are obtained for nonvanishing masses.

  5. Constraints on large extra dimensions from the MINOS experiment

    Science.gov (United States)

    Adamson, P.; Anghel, I.; Aurisano, A.; Barr, G.; Bishai, M.; Blake, A.; Bock, G. J.; Bogert, D.; Cao, S. V.; Carroll, T. J.; Castromonte, C. M.; Chen, R.; Childress, S.; Coelho, J. A. B.; Corwin, L.; Cronin-Hennessy, D.; de Jong, J. K.; de Rijck, S.; Devan, A. V.; Devenish, N. E.; Diwan, M. V.; Escobar, C. O.; Evans, J. J.; Falk, E.; Feldman, G. J.; Flanagan, W.; Frohne, M. V.; Gabrielyan, M.; Gallagher, H. R.; Germani, S.; Gomes, R. A.; Goodman, M. C.; Gouffon, P.; Graf, N.; Gran, R.; Grzelak, K.; Habig, A.; Hahn, S. R.; Hartnell, J.; Hatcher, R.; Holin, A.; Huang, J.; Hylen, J.; Irwin, G. M.; Isvan, Z.; James, C.; Jensen, D.; Kafka, T.; Kasahara, S. M. S.; Koizumi, G.; Kordosky, M.; Kreymer, A.; Lang, K.; Ling, J.; Litchfield, P. J.; Lucas, P.; Mann, W. A.; Marshak, M. L.; Mayer, N.; McGivern, C.; Medeiros, M. M.; Mehdiyev, R.; Meier, J. R.; Messier, M. D.; Miller, W. H.; Mishra, S. R.; Moed Sher, S.; Moore, C. D.; Mualem, L.; Musser, J.; Naples, D.; Nelson, J. K.; Newman, H. B.; Nichol, R. J.; Nowak, J. A.; O'Connor, J.; Orchanian, M.; Pahlka, R. B.; Paley, J.; Patterson, R. B.; Pawloski, G.; Perch, A.; Pfützner, M. M.; Phan, D. D.; Phan-Budd, S.; Plunkett, R. K.; Poonthottathil, N.; Qiu, X.; Radovic, A.; Rebel, B.; Rosenfeld, C.; Rubin, H. A.; Sail, P.; Sanchez, M. C.; Schneps, J.; Schreckenberger, A.; Schreiner, P.; Sharma, R.; Sousa, A.; Tagg, N.; Talaga, R. L.; Thomas, J.; Thomson, M. A.; Tian, X.; Timmons, A.; Todd, J.; Tognini, S. C.; Toner, R.; Torretta, D.; Tzanakos, G.; Urheim, J.; Vahle, P.; Viren, B.; Weber, A.; Webb, R. C.; White, C.; Whitehead, L.; Whitehead, L. H.; Wojcicki, S. G.; Zwaska, R.; Minos Collaboration

    2016-12-01

    We report new constraints on the size of large extra dimensions from data collected by the MINOS experiment between 2005 and 2012. Our analysis employs a model in which sterile neutrinos arise as Kaluza-Klein states in large extra dimensions and thus modify the neutrino oscillation probabilities due to mixing between active and sterile neutrino states. Using Fermilab's Neutrinos at the Main Injector beam exposure of 10.56 ×1 020 protons on target, we combine muon neutrino charged current and neutral current data sets from the Near and Far Detectors and observe no evidence for deviations from standard three-flavor neutrino oscillations. The ratios of reconstructed energy spectra in the two detectors constrain the size of large extra dimensions to be smaller than 0.45 μ m at 90% C.L. in the limit of a vanishing lightest active neutrino mass. Stronger limits are obtained for nonvanishing masses.

  6. Sidestepping the Cosmological Constant with Football-Shaped Extra Dimensions

    CERN Document Server

    Carroll, S M; Carroll, Sean M.; Guica, Monica M.

    2003-01-01

    We present an exact solution for a factorizable brane-world spacetime with two extra dimensions and explicit brane sources. The compactification manifold has the topology of a two-sphere, and is stabilized by a bulk cosmological constant and magnetic flux. The geometry of the sphere is locally round except for conical singularities at the locations of two antipodal branes, deforming the sphere into an American-style football. The bulk magnetic flux needs to be fine-tuned to obtain flat geometry on the branes. Once this is done, the brane geometry is insensitive to the brane vacuum energy, which only affects the conical deficit angle of the extra dimensions. Solutions of this form provide a new arena in which to explore brane-world phenomenology and the effects of extra dimensions on the cosmological constant problem.

  7. Rossby wave extra invariant in the Galerkin approximation

    Science.gov (United States)

    Balk, Alexander M.

    2017-08-01

    The non-linear system of Rossby waves or plasma drift waves is known to have a unique adiabatic-like extra invariant in addition to the energy and enstrophy. This invariant is physically significant because its presence implies the generation of zonal flow. The latter is known to slow down the anomalous transport of temperature and particles in nuclear fusion with magnetic confinement. However, the derivation of the extra invariant - unlike the energy and enstrophy - is based on the continuum of resonances, while in numerical simulations there are only finite number of resonances. We show that precisely the same invariant takes place in the Galerkin approximations (even of low order, with a few ODEs). To show this we make variation of boundary conditions, when the solution is periodic in different directions. We also simplify the derivation of the extra conservation.

  8. Constraints on Large Extra Dimensions from the MINOS Experiment

    CERN Document Server

    Adamson, P; Aurisano, A; Barr, G; Bishai, M; Blake, A; Bock, G J; Bogert, D; Cao, S V; Carroll, T J; Castromonte, C M; Chen, R; Childress, S; Coelho, J A B; Corwin, L; Cronin-Hennessy, D; de Jong, J K; de Rijck, S; Devan, A V; Devenish, N E; Diwan, M V; Escobar, C O; Evans, J J; Falk, E; Feldman, G J; Flanagan, W; Frohne, M V; Gabrielyan, M; Gallagher, H R; Germani, S; Gomes, R A; Goodman, M C; Gouffon, P; Graf, N; Gran, R; Grzelak, K; Habig, A; Hahn, S R; Hartnell, J; Hatcher, R; Holin, A; Huang, J; Hylen, J; Irwin, G M; Isvan, Z; James, C; Jensen, D; Kafka, T; Kasahara, S M S; Koizumi, G; Kordosky, M; Kreymer, A; Lang, K; Ling, J; Litchfield, P J; Lucas, P; Mann, W A; Marshak, M L; Mayer, N; McGivern, C; Medeiros, M M; Mehdiyev, R; Meier, J R; Messier, M D; Miller, W H; Mishra, S R; Sher, S Moed; Moore, C D; Mualem, L; Musser, J; Naples, D; Nelson, J K; Newman, H B; Nichol, R J; Nowak, J A; O'Connor, J; Orchanian, M; Pahlka, R B; Paley, J; Patterson, R B; Pawloski, G; Perch, A; Pfützner, M M; Phan, D D; Phan-Budd, S; Plunkett, R K; Poonthottathil, N; Qiu, X; Radovic, A; Rebel, B; Rosenfeld, C; Rubin, H A; Sail, P; Sanchez, M C; Schneps, J; Schreckenberger, A; Schreiner, P; Sharma, R; Sousa, A; Tagg, N; Talaga, R L; Thomas, J; Thomson, M A; Tian, X; Timmons, A; Todd, J; Tognini, S C; Toner, R; Torretta, D; Tzanakos, G; Urheim, J; Vahle, P; Viren, B; Weber, A; Webb, R C; White, C; Whitehead, L; Whitehead, L H; Wojcicki, S G; Zwaska, R

    2016-01-01

    We report new constraints on the size of large extra dimensions from data collected by the MINOS experiment between 2005 and 2012. Our analysis employs a model in which sterile neutrinos arise as Kaluza-Klein states in large extra dimensions and thus modify the neutrino oscillation probabilities due to mixing between active and sterile neutrino states. Using Fermilab's NuMI beam exposure of $10.56 \\times 10^{20}$ protons-on-target, we combine muon neutrino charged current and neutral current data sets from the Near and Far Detectors and observe no evidence for deviations from standard three-flavor neutrino oscillations. The ratios of reconstructed energy spectra in the two detectors constrain the size of large extra dimensions to be smaller than $0.45\\,\\mu\\text{m}$ at 90% C.L. in the limit of a vanishing lightest active neutrino mass. Stronger limits are obtained for non-vanishing masses.

  9. Constraints on extra dimensions from precision molecular spectroscopy

    CERN Document Server

    Salumbides, E J; Gato-Rivera, B; Ubachs, W

    2015-01-01

    Accurate investigations of quantum level energies in molecular systems are shown to provide a test ground to constrain the size of compactified extra dimensions. This is made possible by the recent progress in precision metrology with ultrastable lasers on energy levels in neutral molecular hydrogen (H$_2$, HD and D$_2$) and the molecular hydrogen ions (H$_2^+$, HD$^+$ and D$_2^+$). Comparisons between experiment and quantum electrodynamics calculations for these molecular systems can be interpreted in terms of probing large extra dimensions, under which conditions gravity will become much stronger. Molecules are a probe of space-time geometry at typical distances where chemical bonds are effective, i.e. at length scales of an \\AA. Constraints on compactification radii for extra dimensions are derived within the Arkani-Hamed-Dimopoulos-Dvali framework, while constraints for curvature or brane separation are derived within the Randall-Sundrum framework. Based on the molecular spectroscopy of D$_2$ molecules an...

  10. Deviations From Newton's Law in Supersymmetric Large Extra Dimensions

    CERN Document Server

    Callin, P

    2006-01-01

    Deviations from Newton's Inverse-Squared Law at the micron length scale are smoking-gun signals for models containing Supersymmetric Large Extra Dimensions (SLEDs), which have been proposed as approaches for resolving the Cosmological Constant Problem. Just like their non-supersymmetric counterparts, SLED models predict gravity to deviate from the inverse-square law because of the advent of new dimensions at sub-millimeter scales. However SLED models differ from their non-supersymmetric counterparts in three important ways: (i) the size of the extra dimensions is fixed by the observed value of the Dark Energy density, making it impossible to shorten the range over which new deviations from Newton's law must be seen; (ii) supersymmetry predicts there to be more fields in the extra dimensions than just gravity, implying different types of couplings to matter and the possibility of repulsive as well as attractive interactions; and (iii) the same mechanism which is purported to keep the cosmological constant natu...

  11. English collocations extracted from a corpus of university learners and its contribution to a language teaching pedagogy=Colocações em inglês extraídas de um corpus de aprendizes universitários e sua contribuição para uma pedagogia no ensino de línguas

    Directory of Open Access Journals (Sweden)

    Adriane Orenha-Ottaiano

    2012-07-01

    Full Text Available Taking into consideration the relevance of foreign language teaching and the learning of collocations (ALTENBERG; EEG-OLOFSSON, 1990; FONTENELLE, 1994; MEUNIER; GRANGER, 2008, this paper aims at showing results of an investigation on whether the teaching of collocations should be implicit or explicit to the Brazilian university students. Furthermore, the research has the purpose of presenting some collocational aspects from a corpus of the written language learners made up of intermediate, upper intermediate and advanced university students’ argumentative essays at a public university in Brazil. With the help of WordSmith Tools (SCOTT, 2007, it was possible to raise students’ most frequent collocational choices and patterns, the most/least used type of collocations, the influence of the mother tongue on their choices, among other aspects. With the purpose of motivating and involving students in classroom research, it was also introduced The Corpus of Contemporary American English (COCA, created by Mark Davies. By doing so, students could compare their collocational choices with the patterns found in the online corpus, extract more collocational patterns and, consequently, be aware of the potential of corpora for the foreign learning process, specifically for raising language awareness, with focus on prefabricated chunks.Considerando a relevância das colocações para o ensino-aprendizagem de língua estrangeira (ALTENBERG; EEG-OLOFSSON, 1990; FONTENELLE, 1994; MEUNIER; GRANGER, 2008, este artigo tem como propósito mostrar os resultados de uma investigação a respeito do ensino implícito ou explícito de colocações para alunos universitários brasileiros. Além disso, a pesquisa visa apresentar alguns aspectos colocacionais, levantados a partir de um corpus de aprendizes de língua escrita, composto por textos argumentativos de alunos de nível intermediário, intermediário avançado e avançado, de uma universidade pública, no Brasil

  12. Decipher test impacts decision making among patients considering adjuvant and salvage treatment after radical prostatectomy: Interim results from the Multicenter Prospective PRO-IMPACT study.

    Science.gov (United States)

    Gore, John L; du Plessis, Marguerite; Santiago-Jiménez, María; Yousefi, Kasra; Thompson, Darby J S; Karsh, Lawrence; Lane, Brian R; Franks, Michael; Chen, David Y T; Bandyk, Mark; Bianco, Fernando J; Brown, Gordon; Clark, William; Kibel, Adam S; Kim, Hyung L; Lowrance, William; Manoharan, Murugesan; Maroni, Paul; Perrapato, Scott; Sieber, Paul; Trabulsi, Edouard J; Waterhouse, Robert; Davicioni, Elai; Lotan, Yair; Lin, Daniel W

    2017-08-01

    Patients with prostate cancer and their providers face uncertainty as they consider adjuvant radiotherapy (ART) or salvage radiotherapy (SRT) after undergoing radical prostatectomy. The authors prospectively evaluated the impact of the Decipher test, which predicts metastasis risk after radical prostatectomy, on decision making for ART and SRT. A total of 150 patients who were considering ART and 115 who were considering SRT were enrolled. Providers submitted a management recommendation before processing the Decipher test and again at the time of receipt of the test results. Patients completed validated surveys on prostate cancer (PCa)-specific decisional effectiveness and PCa-related anxiety. Before the Decipher test, observation was recommended for 89% of patients considering ART and 58% of patients considering SRT. After Decipher testing, 18% (95% confidence interval [95% CI], 12%-25%) of treatment recommendations changed in the ART arm, including 31% among high-risk patients; and 32% (95% CI, 24%-42%) of management recommendations changed in the salvage arm, including 56% among high-risk patients. Decisional Conflict Scale (DCS) scores were better after viewing Decipher test results (ART arm: median DCS before Decipher, 25 and after Decipher, 19 [P<.001]; SRT arm: median DCS before Decipher, 27 and after Decipher, 23 [P<.001]). PCa-specific anxiety changed after Decipher testing; fear of PCa disease recurrence in the ART arm (P = .02) and PCa-specific anxiety in the SRT arm (P = .05) decreased significantly among low-risk patients. Decipher results reported per 5% increase in 5-year metastasis probability were associated with the decision to pursue ART (odds ratio, 1.48; 95% CI, 1.19-1.85) and SRT (odds ratio, 1.41; 95% CI, 1.09-1.81) in multivariable logistic regression analysis. Knowledge of Decipher test results was associated with treatment decision making and improved decisional effectiveness among men with PCa who were considering ART and SRT. Cancer 2017

  13. Ways to Promote the Classroom Participation of International Students by Understanding the Silence of Japanese University Students

    Science.gov (United States)

    Kim, Soonhyang; Ates, Burcu; Grigsby, Yurimi; Kraker, Stefani; Micek, Timothy A.

    2016-01-01

    The authors explored the role of silence and deciphered its meaning and usefulness as a teaching and learning strategy for Japanese students through a survey of Japanese university students in their home country. This study has revealed that participant responses were evenly divided among comfortable with silence, uncomfortable with silence, and…

  14. The epidemiology of extra-articular manifestations in ankylosing spondylitis

    DEFF Research Database (Denmark)

    Stolwijk, Carmen; Essers, Ivette; van Tubergen, Astrid

    2015-01-01

    OBJECTIVE: To assess the incidence and risks of common extra-articular manifestations (EAMs), that is, acute anterior uveitis (AAU), psoriasis and inflammatory bowel disease (IBD), in patients with ankylosing spondylitis (AS) compared with population-based controls. METHODS: All incident patients...

  15. The blessing effect of an extra copy of chromosome 21

    African Journals Online (AJOL)

    Solaf M. Elsayed

    2014-02-25

    Feb 25, 2014 ... The protective effect of the extra copy of chromosome against the ... genesis by decreasing the vascular endothelial growth factor. C (VEGF-C) levels in .... [8] Sun Y, Wang J, Liu Y, Song X, Zhang Y, Li K, et al. Results of.

  16. Clinical importance of extra vitamins from supplements and enriched foodstuffs

    NARCIS (Netherlands)

    Hermus, R.J.J.; Severs, A.H.

    1999-01-01

    -Consumers increasingly use vitamin supplements. Also, since June 1996, foodstuffs enriched with vitamins are available on the Dutch market. -These sources of extra vitamins may be useful for groups at risk for marginal vitamin deficiencies. -These risk groups include the chronically ill (e.g. diabe

  17. The ‘Deployment of Extra Processing’ Account of Attention

    DEFF Research Database (Denmark)

    Fazekas, Peter; Nanay, Bence

    2015-01-01

    The paper formulates an alternative view about the core function of attention claiming that attention is not selection but the deployment of extra processing capacity. This way of thinking about attention has greater explanatory power, since it proposes a common implementation both for selection...

  18. Sarcoma sinovial extra-articular em cão

    OpenAIRE

    França,S.A.; Serakides,R.; Silva,A.E.; Rachid,M.A.; J.R.C. Moraes; Lavalle,G.E.; Ocarino,N.M.

    2004-01-01

    One four-year-old, female, Collie, dog presented subcutaneous enlarged mass at the lateral aspect of the left hindlimb, close to the knee joint. Based on the anatomopathological and immunohistochemical findings it was confirmed the diagnosis of extra-articular bifasic synovial sarcoma - grade II.

  19. Search for large extra dimensions in diphoton events at CDF

    CERN Document Server

    Murgia, S

    2002-01-01

    In spite of its undisputed success, the Standard Model is not a theory of everything as it does not incorporate gravity. Gravity is the weakest of all forces and its strength becomes comparable to the remaining forces at energies of the order of the Planck scale, at approximately 10 19 GeV and the Standard Model is viewed as an effective theory at energies below this scale. Recently, a model of large extra dimensions has been formulated by Arkani-Hamed, Dimopoulous, and Dvali that claims that the electroweak scale (approximately 1 TeV) is the only fundamental scale in nature and the fact that the Planck scale appears so large is an artifact of the existence of extra dimensions in which only gravity propagates. This theory can be tested at existing collider experiments, where energies sufficiently high to probe the extra dimensions can be achieved. In particular, the existence of extra dimensions can manifest itself with production of Standard Model particles through graviton mediated processes and thus it pre...

  20. Injuries in Children with Extra Physical Education in Primary Schools

    DEFF Research Database (Denmark)

    Rexen, Christina; Andersen, Lars Bo; Ersbøll, Annette Kjær

    2014-01-01

    (1) Examine the influence of extra physical education (EPE) on the number of musculoskeletal injuries in public schools accounting for organized sports participation (OSP) outside school. (2) Examine the major injury subgroup: growth-related overuse (GRO) through the overuse-related injury group....

  1. Search and investigation of extra-solar planets with polarimetry

    Science.gov (United States)

    Schmid, H. M.; Beuzit, J.-L.; Feldt, M.; Gisler, D.; Gratton, R.; Henning, Th.; Joos, F.; Kasper, M.; Lenzen, R.; Mouillet, D.; Moutou, C.; Quirrenbach, A.; Stam, D. M.; Thalmann, C.; Tinbergen, J.; Verinaud, C.; Waters, R.; Wolstencroft, R.

    Light reflected from planets is polarized. This basic property of planets provides the possibility for detecting and characterizing extra-solar planets using polarimetry. The expected polarization properties of extra-solar planets are discussed that can be inferred from polarimetry of "our" solar system planets. They show a large variety of characteristics depending on the atmospheric and/or surface properties. Best candidates for a polarimetric detection are extra-solar planets with an optically thick Rayleigh scattering layer.Even the detection of highly polarized extra-solar planets requires a very sophisticated instrument. We present the results from a phase A (feasibility) study for a polarimetric arm in the ESO VLT planet finder instrument. It is shown that giant planets around nearby stars can be searched and investigated with an imaging polarimeter, combined with a powerful AO system and a coronagraph at an 8 m class telescope.A similar type of polarimeter is also considered for the direct detection of terrestrial planets using an AO system on one of the future Extremely Large Telescopes.

  2. Extra nodal growth as a prognostic factor in malignant melanoma

    NARCIS (Netherlands)

    Koopal, SA; Tiebosch, ATMG; Daryanani, D; Plukker, JTM; Hoekstra, HJ

    Aim. Extra nodal growth (ENG) in lymph-node metastases may be an additional. indicator for poor prognosis and increased Loco-regional recurrence in patients with a cutaneous malignant melanoma (CMM). Most studies analyzing prognostic factors tack a proper definition or description of the

  3. Search for extra-dimensions in the ATLAS experiment

    CERN Document Server

    Brochu, F M

    2004-01-01

    We report on the most recent simulation studies performed in the ATLAS experiment, looking for new phenomena in proton--proton collisions predicted by different models involving extra space dimensions to solve the hierarchy problem. All studies performed here used the fast, parametrized simulation of the ATLAS detector, ATLFAST.

  4. Extra-Curricular Activities and Academic Performance in Secondary Students

    Science.gov (United States)

    Moriana, Juan Antonio; Alos, Francisco; Alcala, Rocio; Pino, Maria-Jose; Herruzo, Javier; Ruiz, Rosario

    2006-01-01

    Introduction: In this paper we study the possible influence of extra-curricular activities (study-related and/or sports) on academic performance of first- and second-year pupils in "Educacion Secundaria Obligatoria (ESO)" [N.T. seventh- and eighth-graders]. Method: We randomly selected 12 schools in the city (9 public and 3 private), and…

  5. Chemical changes in extra virgin argan oil after thermal treatment.

    Science.gov (United States)

    Gharby, Saïd; Harhar, Hicham; Kartah, Badr Eddine; Guillaume, Dom; Charrouf, Zoubida

    2013-01-01

    Physicochemical parameters, measured every 6 hours, of extra virgin argan oil heated for 24 h at 180 degrees C were investigated and compared with those of five other edible oils treated in the same thermoxidative condition. Argan oil was found to be particularly stable at high temperature, its level of polar compounds remaining low even after 24 h of heating.

  6. Extra-Curricular Activities and Academic Performance in Secondary Students

    Science.gov (United States)

    Moriana, Juan Antonio; Alos, Francisco; Alcala, Rocio; Pino, Maria-Jose; Herruzo, Javier; Ruiz, Rosario

    2006-01-01

    Introduction: In this paper we study the possible influence of extra-curricular activities (study-related and/or sports) on academic performance of first- and second-year pupils in "Educacion Secundaria Obligatoria (ESO)" [N.T. seventh- and eighth-graders]. Method: We randomly selected 12 schools in the city (9 public and 3 private), and…

  7. Surgery for extra-articular trismus : a systematic review

    NARCIS (Netherlands)

    Bouman, M. A.; Dijkstra, P. U.; Reintsema, H.; Roodenburg, J. L. N.; Werkera, P. M. N.

    The aim of this systematic review was to identify operations that are used to improve mouth opening in patients with extra-articular trismus (caused by cancer and its treatment, oral submucous fibrosis, or noma) and to find out if they work. We searched the electronic databases PubMed, Embase,

  8. Overheden bereid extra te betalen voor auto's op alternatieve brandstof

    NARCIS (Netherlands)

    Rijnsoever, F.J. van; Hagen, Paul

    2012-01-01

    De elektrische auto en een auto op groen gas worden door overheden hoger gewaardeerd dan de auto met reguliere verbrandingsmotor. Bovendien zijn overheden bereid extra te betalen voor een auto op alternatieve brandstof. Dit blijkt uit een masteronderzoek van de Universiteit Utrecht in opdracht

  9. Clinical importance of extra vitamins from supplements and enriched foodstuffs

    NARCIS (Netherlands)

    Hermus, R.J.J.; Severs, A.H.

    1999-01-01

    -Consumers increasingly use vitamin supplements. Also, since June 1996, foodstuffs enriched with vitamins are available on the Dutch market. -These sources of extra vitamins may be useful for groups at risk for marginal vitamin deficiencies. -These risk groups include the chronically ill (e.g. diabe

  10. Estimating the extra cost of living with disability in Vietnam.

    Science.gov (United States)

    Minh, Hoang Van; Giang, Kim Bao; Liem, Nguyen Thanh; Palmer, Michael; Thao, Nguyen Phuong; Duong, Le Bach

    2015-01-01

    Disability is shown to be both a cause and a consequence of poverty. However, relatively little research has investigated the economic cost of living with a disability. This study reports the results of a study on the extra cost of living with disability in Vietnam in 2011. The study was carried out in eight cities/provinces in Vietnam, including Hanoi and Ho Chi Minh cities (two major metropolitan in Vietnam) and six provinces from each of the six socio-economic regions in Vietnam. Costs are estimated using the standard of living approach whereby the difference in incomes between people with disability and those without disability for a given standard of living serves as a proxy for the cost of living with disability. The extra cost of living with disability in Vietnam accounted for about 8.8-9.5% of annual household income, or valued about US$200-218. Communication difficulty was shown to result in highest additional cost of living with disability and self-care difficulty was shown to lead to the lowest levels of extra of living cost. The extra cost of living with disability increased as people had more severe impairment. Interventions to promote the economic security of livelihood for people with disabilities are needed.

  11. Charged current unitarity and extra neutral gauge bosons

    Energy Technology Data Exchange (ETDEWEB)

    Marciano, W.J.; Sirling, A.

    1987-03-01

    The experimental status of the Kobayashi-Maskawa-Cabibbo (KMC) matrix is surveyed and shown to provide a precision test of the standard model at the level of its O(..cap alpha..) radiative corrections. Implications for new physics and constraints of extra neutral gauge bosons are described. 12 refs., 1 fig.

  12. Surgery for extra-articular trismus : a systematic review

    NARCIS (Netherlands)

    Bouman, M A; Dijkstra, P U; Reintsema, H; Roodenburg, J L N; Werker, P M N

    2015-01-01

    The aim of this systematic review was to identify operations that are used to improve mouth opening in patients with extra-articular trismus (caused by cancer and its treatment, oral submucous fibrosis, or noma) and to find out if they work. We searched the electronic databases PubMed, Embase, Cinah

  13. Surgery for extra-articular trismus : a systematic review

    NARCIS (Netherlands)

    Bouman, M. A.; Dijkstra, P. U.; Reintsema, H.; Roodenburg, J. L. N.; Werkera, P. M. N.

    2016-01-01

    The aim of this systematic review was to identify operations that are used to improve mouth opening in patients with extra-articular trismus (caused by cancer and its treatment, oral submucous fibrosis, or noma) and to find out if they work. We searched the electronic databases PubMed, Embase, Cinah

  14. Extra-Curricular Activities and Academic Performance in Secondary Students

    Science.gov (United States)

    Moriana, Juan Antonio; Alos, Francisco; Alcala, Rocio; Pino, Maria-Jose; Herruzo, Javier; Ruiz, Rosario

    2006-01-01

    Introduction: In this paper we study the possible influence of extra-curricular activities (study-related and/or sports) on academic performance of first- and second-year pupils in "Educacion Secundaria Obligatoria (ESO)" [N.T. seventh- and eighth-graders]. Method: We randomly selected 12 schools in the city (9 public and 3 private), and randomly…

  15. Extra-articular Mimickers of Lateral Meniscal Tears

    Science.gov (United States)

    Barker, Joseph U.; Strauss, Eric J.; Lodha, Sameer; Bach, Bernard R.

    2011-01-01

    Context: Lateral meniscus tears are a common entity seen in sports medicine. Although lateral-side knee pain is often the result of a meniscus injury, several extra-articular pathologies share signs and symptoms with a meniscus tear. It is critical for the clinician to be able to identify and understand extra-articular pathologies that can present similar to a lateral meniscus tear. Evidence Acquisition: Data were collected through a thorough review of the literature conducted through a MEDLINE search for all relevant articles between 1980 and February 2010. Study Type: Clinical review. Results: Common extra-articular pathologies that can mimic lateral meniscal tears include iliotibial band syndrome, proximal tibiofibular joint instability, snapping biceps femoris or popliteus tendons, and peroneal nerve compression syndrome or neuritis. The patient history, physical examination features, and radiographic findings can be used to separate these entities from the more common intra-articular knee pathologies. Conclusions: In treating patients who present with lateral-sided knee pain, clinicians should be able to recognize and treat extra-articular pathologies that can present in a similar fashion as lateral meniscus tears. PMID:23015995

  16. Search for large extra dimensions in diphoton events at CDF

    Science.gov (United States)

    Murgia, Simona

    In spite of its undisputed success, the Standard Model is not a theory of everything as it does not incorporate gravity. Gravity is the weakest of all forces and its strength becomes comparable to the remaining forces at energies of the order of the Planck scale, at approximately 10 19 GeV and the Standard Model is viewed as an effective theory at energies below this scale. Recently, a model of large extra dimensions has been formulated by Arkani-Hamed, Dimopoulous, and Dvali that claims that the electroweak scale (approximately 1 TeV) is the only fundamental scale in nature and the fact that the Planck scale appears so large is an artifact of the existence of extra dimensions in which only gravity propagates. This theory can be tested at existing collider experiments, where energies sufficiently high to probe the extra dimensions can be achieved. In particular, the existence of extra dimensions can manifest itself with production of Standard Model particles through graviton mediated processes and thus it predicts an enhancement of production cross sections at high invariant mass. The goal of this work is to search for an excess in the 100 pb-1 of diphoton data collected with the Collider Detector at Fermilab at s = 1.8 TeV during the 1992--1996 run. No excess is observed and thus we place a 95% confidence level limit on the Planck scale in the bulk extra dimensions MS of 899 GeV for constructive interference and of 797 GeV for destructive interference (Hewett convention).

  17. Impact of horizontal spatial resolution on the derivation of the source receptor relationship—an extra-tropical cyclone case

    Science.gov (United States)

    Lee, Jae-Bum; Lee, Tae-Young

    2004-11-01

    A numerical study has been made to evaluate the impact of horizontal resolution on the estimation of the source receptor (S R) relationship. Numerical experiments with four different horizontal grid sizes have been performed for an extra-tropical cyclonic episode in East Asia. CSU RAMS and YU-SADM (Yonsei University's sulfuric acid deposition model) have been used to simulate meteorological and pollutant fields, respectively.In this study, enhanced spatial resolution has improved the simulation of an extra-tropical cyclone, cold front and associated precipitation systems. As spatial resolution increases, the circulation associated with the cyclone and cold front becomes stronger, and the amount of frontal rainfall increases. This study has shown that enhancement of spatial resolution tends to increase self-contributions but decrease foreign contributions to the wet deposition associated with an extra-tropical cyclone. It has been found that increased precipitation for enhanced spatial resolution reduces the amount of transported pollutant but increases the wet deposition of locally emitted pollutants. The larger self-contribution for higher resolutions may also be partially due to the increased strength of resolved convection. The impact of enhancing spatial resolution on dry deposition is felt mostly over downstream regions where the centres of the lows and fronts pass. Contributions from upstream sources increase as cyclonic circulation becomes stronger with increasing spatial resolution. On the other hand, enhancing spatial resolution does not significantly affect the S R relationship for either dry or wet deposition in the other regions where the extra-tropical cyclone does not pass. This study indicates that improved simulation of a cold front does not significantly affect the S R relationship for wet deposition over the area of passage of the cold front. An additional discussion infers a S R relationship for the wet deposition associated with a typical extra

  18. Sarcoma sinovial extra-articular em cão Extra-articular synovial sarcoma in a dog

    Directory of Open Access Journals (Sweden)

    S.A. França

    2004-10-01

    Full Text Available One four-year-old, female, Collie, dog presented subcutaneous enlarged mass at the lateral aspect of the left hindlimb, close to the knee joint. Based on the anatomopathological and immunohistochemical findings it was confirmed the diagnosis of extra-articular bifasic synovial sarcoma - grade II.

  19. Klinische betekenis van extra vitaminen uit supplementen en verrijkte voedingsmiddelen [Clinical importance of extra vitamins from supplements and enriched foodstuffs

    NARCIS (Netherlands)

    Hermus, R.J.J.; Severs, A.H.

    1999-01-01

    -Consumers increasingly use vitamin supplements. Also, since June 1996, foodstuffs enriched with vitamins are available on the Dutch market. -These sources of extra vitamins may be useful for groups at risk for marginal vitamin deficiencies. -These risk groups include the chronically ill (e.g.

  20. An overview of the EXTraS project: Exploring the X-ray Transient and Variable Sky

    CERN Document Server

    De Luca, A; Tiengo, A; D'Agostino, D; Watson, M G; Haberl, F; Wilms, J

    2015-01-01

    The EXTraS project (Exploring the X-ray Transient and variable Sky) will harvest the hitherto unexplored temporal domain information buried in the serendipitous data collected by the European Photon Imaging Camera (EPIC) instrument onboard the ESA XMM-Newton X-ray observatory since its launch. This will include a search for fast transients, as well as a search and characterization of variability (both periodic and aperiodic) in hundreds of thousands of sources spanning more than nine orders of magnitude in time scale and six orders of magnitude in flux. X-ray results will be complemented by multiwavelength characterization of new discoveries. Phenomenological classification of variable sources will also be performed. All our results will be made available to the community. A didactic program in selected High Schools in Italy, Germany and the UK will also be implemented. The EXTraS project (2014-2016), funded within the EU/FP7 framework, is carried out by a collaboration including INAF (Italy), IUSS (Italy), C...

  1. Developmental integration in a functional unit: deciphering processes from adult dental morphology.

    Science.gov (United States)

    Labonne, Gaëlle; Navarro, Nicolas; Laffont, Rémi; Chateau-Smith, Carmela; Montuire, Sophie

    2014-01-01

    The evolution of mammalian dentition is constrained by functional necessity and by the non-independence of morphological structures. Efficient chewing implies coherent tooth coordination from development to motion, involving covariation patterns (integration) within dental parts. Using geometric morphometrics, we investigate the modular organization of the highly derived vole dentition. Integration patterns between and within the upper and lower molar rows are analyzed to identify potential modules and their origins (functional and developmental). Results support an integrated adult dentition pattern for both developmental and functional aspects. The integration patterns between opposing molar pairs suggest a transient role for the second upper and lower molars during the chewing motion. Upper and lower molar rows form coherent units but the relative integration of molar pairs is in contradiction with existing developmental models. Emphasis on the first three cusps to grow leads to a very different integration pattern, which would be congruent with developmental models. The early developmental architecture of traits is masked by later stages of growth, but may still be deciphered from the adult phenotype, if careful attention is paid to relevant features.

  2. Deciphering the genetic regulatory code using an inverse error control coding framework.

    Energy Technology Data Exchange (ETDEWEB)

    Rintoul, Mark Daniel; May, Elebeoba Eni; Brown, William Michael; Johnston, Anna Marie; Watson, Jean-Paul

    2005-03-01

    We have found that developing a computational framework for reconstructing error control codes for engineered data and ultimately for deciphering genetic regulatory coding sequences is a challenging and uncharted area that will require advances in computational technology for exact solutions. Although exact solutions are desired, computational approaches that yield plausible solutions would be considered sufficient as a proof of concept to the feasibility of reverse engineering error control codes and the possibility of developing a quantitative model for understanding and engineering genetic regulation. Such evidence would help move the idea of reconstructing error control codes for engineered and biological systems from the high risk high payoff realm into the highly probable high payoff domain. Additionally this work will impact biological sensor development and the ability to model and ultimately develop defense mechanisms against bioagents that can be engineered to cause catastrophic damage. Understanding how biological organisms are able to communicate their genetic message efficiently in the presence of noise can improve our current communication protocols, a continuing research interest. Towards this end, project goals include: (1) Develop parameter estimation methods for n for block codes and for n, k, and m for convolutional codes. Use methods to determine error control (EC) code parameters for gene regulatory sequence. (2) Develop an evolutionary computing computational framework for near-optimal solutions to the algebraic code reconstruction problem. Method will be tested on engineered and biological sequences.

  3. Deciphering interference control in adults with ADHD by using distribution analyses and electromyographic activity.

    Science.gov (United States)

    Suarez, Isabel; Burle, B; Tobon, C; Pineda, D; Lopera, F; Hasbroucq, T; Casini, L

    2015-07-01

    A deficit in "interference control" is commonly found in adults with Attention Deficit Hyperactivity Disorder (ADHD). This has mainly been interpreted as difficulties in inhibiting inappropriate responses. However, interference control involves processes other than simply the ability to inhibit. Consequently, we used sophisticated analysis to decipher the additional processes of interference control in these patients. We compared interference control between 16 adults with ADHD and 15 control adults performing a Simon task. In most studies, performance is generally reported in terms of mean error rates and reaction times (RTs). However, here we used distribution analyses of behavioral data, complemented by analyses of electromyographic (EMG) activity. This allowed us to better quantify the control of interference, specifically the part that remains hidden when pure correct trials are not distinguished from partial errors. Partial errors correspond to sub-threshold EMG bursts induced by incorrect responses that immediately precede a correct response. Moreover, besides "online" control, we also investigated cognitive control effects manifesting across consecutive trials. The main findings were that adults with ADHD were slower and showed a larger interference effect in comparison to controls. However, the data revealed that the larger interference effect was due neither to higher impulse expression, nor to a deficit in inhibition but that these patients presented a larger interference effect than the controls after congruent trials. We propose and discuss the hypothesis that the interference control deficit found in adults with ADHD is secondary to impairments in sustained attention.

  4. Deciphering genetic diversity and inheritance of tomato fruit weight and composition through a systems biology approach.

    Science.gov (United States)

    Pascual, Laura; Xu, Jiaxin; Biais, Benoît; Maucourt, Mickaël; Ballias, Patricia; Bernillon, Stéphane; Deborde, Catherine; Jacob, Daniel; Desgroux, Aurore; Faurobert, Mireille; Bouchet, Jean-Paul; Gibon, Yves; Moing, Annick; Causse, Mathilde

    2013-12-01

    Integrative systems biology proposes new approaches to decipher the variation of phenotypic traits. In an effort to link the genetic variation and the physiological and molecular bases of fruit composition, the proteome (424 protein spots), metabolome (26 compounds), enzymatic profile (26 enzymes), and phenotypes of eight tomato accessions, covering the genetic diversity of the species, and four of their F1 hybrids, were characterized at two fruit developmental stages (cell expansion and orange-red). The contents of metabolites varied among the genetic backgrounds, while enzyme profiles were less variable, particularly at the cell expansion stage. Frequent genotype by stage interactions suggested that the trends observed for one accession at a physiological level may change in another accession. In agreement with this, the inheritance modes varied between crosses and stages. Although additivity was predominant, 40% of the traits were non-additively inherited. Relationships among traits revealed associations between different levels of expression and provided information on several key proteins. Notably, the role of frucktokinase, invertase, and cysteine synthase in the variation of metabolites was highlighted. Several stress-related proteins also appeared related to fruit weight differences. These key proteins might be targets for improving metabolite contents of the fruit. This systems biology approach provides better understanding of networks controlling the genetic variation of tomato fruit composition. In addition, the wide data sets generated provide an ideal framework to develop innovative integrated hypothesis and will be highly valuable for the research community.

  5. Deciphering the Mechanisms of Developmental Disorders (DMDD: a new programme for phenotyping embryonic lethal mice

    Directory of Open Access Journals (Sweden)

    Timothy Mohun

    2013-05-01

    International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised. These homozygous lethal mutants represent a potential treasure trove for the biomedical community. Developmental biologists could exploit them in their studies of tissue differentiation and organogenesis; for clinical researchers they offer a powerful resource for investigating the origins of developmental diseases that affect newborns. Here, we outline a new programme of research in the UK aiming to kick-start research with embryonic lethal mouse lines. The ‘Deciphering the Mechanisms of Developmental Disorders’ (DMDD programme has the ambitious goal of identifying all embryonic lethal knockout lines made in the UK over the next 5 years, and will use a combination of comprehensive imaging and transcriptomics to identify abnormalities in embryo structure and development. All data will be made freely available, enabling individual researchers to identify lines relevant to their research. The DMDD programme will coordinate its work with similar international efforts through the umbrella of the International Mouse Phenotyping Consortium [see accompanying Special Article (Adams et al., 2013] and, together, these programmes will provide a novel database for embryonic development, linking gene identity with molecular profiles and morphology phenotypes.

  6. Deciphering the functions and regulation of brain-enriched A-to-I RNA editing.

    Science.gov (United States)

    Li, Jin Billy; Church, George M

    2013-11-01

    Adenosine-to-inosine (A-to-I) RNA editing, in which genomically encoded adenosine is changed to inosine in RNA, is catalyzed by adenosine deaminase acting on RNA (ADAR). This fine-tuning mechanism is critical during normal development and diseases, particularly in relation to brain functions. A-to-I RNA editing has also been hypothesized to be a driving force in human brain evolution. A large number of RNA editing sites have recently been identified, mostly as a result of the development of deep sequencing and bioinformatic analyses. Deciphering the functional consequences of RNA editing events is challenging, but emerging genome engineering approaches may expedite new discoveries. To understand how RNA editing is dynamically regulated, it is imperative to construct a spatiotemporal atlas at the species, tissue and cell levels. Future studies will need to identify the cis and trans regulatory factors that drive the selectivity and frequency of RNA editing. We anticipate that recent technological advancements will aid researchers in acquiring a much deeper understanding of the functions and regulation of RNA editing.

  7. Deciphering systemic lupus erythematosus-associated serum biomarkers reflecting apoptosis and disease activity.

    Science.gov (United States)

    Delfani, P; Sturfelt, G; Gullstrand, B; Carlsson, A; Kassandra, M; Borrebaeck, C A K; Bengtsson, A A; Wingren, C

    2017-04-01

    Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important etiopathogenic event in SLE, which could contribute to the increased load of potential autoantigen(s); however, the lack of disease-specific protein signatures deciphering SLE and the underlying biological processes is striking and represents a key limitation. In this retrospective pilot study, we explored the immune system as a specific sensor for disease, in order to advance our understanding of SLE. To this end, we determined multiplexed serum protein expression profiles of crude SLE serum samples, using antibody microarrays. The aim was to identify differential immunoprofiles, or snapshots of the immune response modulated by the disease, reflecting apoptosis, a key process in the etiology of SLE and disease activity. The results showed that multiplexed panels of SLE-associated serum biomarkers could be decoded, in particular reflecting disease activity, but potentially the apoptosis process as well. While the former biomarkers could display a potential future use for prognosis, the latter biomarkers might help shed further light on the apoptosis process taking place in SLE.

  8. Deciphering elapsed time and predicting action timing from neuronal population signals

    Directory of Open Access Journals (Sweden)

    Shigeru eShinomoto

    2011-06-01

    Full Text Available The proper timing of actions is necessary for the survival of animals, whether in hunting prey or escaping predators. Researchers in the field of neuroscience have begun to explore neuronal signals correlated to behavioral interval timing. Here, we attempt to decode the lapse of time from neuronal population signals recorded from the frontal cortex of monkeys performing a multiple-interval timing task. We designed a Bayesian algorithm that deciphers temporal information hidden in noisy signals dispersed within the activity of individual neurons recorded from monkeys trained to determine the passage of time before initiating an action. With this decoder, we succeeded in estimating the elapsed time with a precision of approximately 1 sec throughout the relevant behavioral period from firing rates of 25 neurons in the pre-supplementary motor area. Further, an extended algorithm makes it possible to determine the total length of the time interval required to wait in each trial. This enables observers to predict the moment at which the subject will take action from the neuronal activity in the brain. A separate population analysis reveals that the neuronal ensemble represents the lapse of time in a manner scaled relative to the scheduled interval, rather than representing it as the real physical time.

  9. Deciphering Transcriptional Programming during Pod and Seed Development Using RNA-Seq in Pigeonpea (Cajanus cajan)

    Science.gov (United States)

    Pazhamala, Lekha T.; Agarwal, Gaurav; Bajaj, Prasad; Kumar, Vinay; Kulshreshtha, Akanksha; Saxena, Rachit K.; Varshney, Rajeev K.

    2016-01-01

    Seed development is an important event in plant life cycle that has interested humankind since ages, especially in crops of economic importance. Pigeonpea is an important grain legume of the semi-arid tropics, used mainly for its protein rich seeds. In order to understand the transcriptional programming during the pod and seed development, RNA-seq data was generated from embryo sac from the day of anthesis (0 DAA), seed and pod wall (5, 10, 20 and 30 DAA) of pigeonpea variety “Asha” (ICPL 87119) using Illumina HiSeq 2500. About 684 million sequencing reads have been generated from nine samples, which resulted in the identification of 27,441 expressed genes after sequence analysis. These genes have been studied for their differentially expression, co-expression, temporal and spatial gene expression. We have also used the RNA-seq data to identify important seed-specific transcription factors, biological processes and associated pathways during seed development process in pigeonpea. The comprehensive gene expression study from flowering to mature pod development in pigeonpea would be crucial in identifying candidate genes involved in seed traits directly or indirectly related to yield and quality. The dataset will serve as an important resource for gene discovery and deciphering the molecular mechanisms underlying various seed related traits. PMID:27760186

  10. Deciphering Corporate Governance and Environmental Commitments among Southeast Asian Transnationals: Uptake of Sustainability Certification

    Directory of Open Access Journals (Sweden)

    Jean-Marc Roda

    2015-04-01

    Full Text Available Promoting tropical forest sustainability among corporate players is a major challenge. Many tools have been developed, but without much success. Southeast Asia has become a laboratory of globalization processes, where the development and success of agribusiness transnationals raises questions about their commitment to environmental concerns. An abundance of literature discusses what determines the behavior of Asian corporations, with a particular emphasis on cultural factors. Our hypothesis is that financial factors, such as ownership structure, may also have a fundamental role. We analyzed the audited accounts of four major Asian agribusiness transnationals. Using network analysis, we deciphered how the 931 companies relate to each other and determine the behavior of the transnationals to which they belong. We compared various metrics with the environmental commitment of these transnationals. We found that ownership structures reflect differences in flexibility, control and transaction costs, but not in ethnicities. Capital and its control, ownership structure, and flexibility explain 97% of the environmental behavior. It means that existing market-based tools to promote environmental sustainability do not engage transnationals at the scale where most of their behavior is determined. For the first time, the inner mechanisms of corporate governance are unraveled in agricultural and forest sustainability. New implications such as the convergence of environmental sustainability with family business sustainability emerged.

  11. Prevalence of Extra Roots in Permanent Mandibular First Molars in Iranian Population: A CBCT Analysis

    Science.gov (United States)

    Rahimi, Saeed; Mokhtari, Hadi; Ranjkesh, Bahram; Johari, Masoomeh; Frough Reyhani, Mohammad; Shahi, Shahriar; Seif Reyhani, Sina

    2017-01-01

    Introduction: Having knowledge about the anatomy of root canal system is essential for success of endodontic treatment. The present study used cone-beam computed tomography (CBCT), to evaluate the prevalence of third root in mandibular first molars in a selected Iranian population. Methods and Materials: A total of 386 CBCT images from subjects referred to oral and maxillofacial radiology department of dental faculty of Tabriz University of Medical Sciences from 2011 to 2013 were selected and evaluated for this study and the cases with well-developed permanent mandibular first molars were included. The 3D images were reconstructed in axial cross sections and evaluated by two endodontists for the presence of the third extra lingual (radix entomolaris) or buccal (radix paramolaris) root. The chi-squared test was used to evaluate the relationship between gender and bilateral incidence of extra roots in mandibular first molars. Results: The distribution of three-rooted mandibular first molars with an additional root was 3%, (3.53% in female and 2.50% in male patients). There was no significant relationship between gender and bilateral occurrence of three-rooted mandibular first molars. Conclusion: The occurrence of three-rooted mandibular first molars in Iranian population is not uncommon which should be taken into consideration by the dental practitioners during root canal treatment of these teeth. PMID:28179928

  12. Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect

    Science.gov (United States)

    Pigatti, Fernanda-Mombrini; Martins-Mussi, Maria-Carolina; Sedassari, Bruno-Tavares; Orsini-Machado de Sousa, Suzana-Cantanhede

    2017-01-01

    Background Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses. Material and Methods We retrieved all cases diagnosed with oral granular cell tumor, from the Oral Pathology Service at the School of Dentistry/ University of São Paulo, and excluded the ones sited in the tongue. Immunohistochemical staining anti-S100 was also performed. Results The presented cases of Extra-tongue Oral Granular Cell Tumor (ETOGT) are composed by granular cells with intimately association with the adjacent tissue. Atypia and mitoses were not seen, and in most cases, the typical pseudoepitheliomatous hyperplasia was not observed. Conclusions The importance of an adequate attention is to avoid misdiagnoses, since ETOGT is rare and the tricking histopathological findings could induce to it. All the cases can be differentiated from the tumors that has a granular cell proliferation through a morphological analysis and when needed, immunohistochemistry stain. Key words:Abrikossoff`s tumor, granular cell tumor, oral cavity. PMID:27918739

  13. The Radionactive Universe

    CERN Document Server

    Kolb, Edward W; Tait, T M P; Kolb, Edward W.; Servant, Geraldine; Tait, Tim M. P.

    2003-01-01

    In a large class of extra-dimensional models, a scalar degree of freedom known as the radion is long-lived, or even stable, on cosmological scales. In this paper we investigate the impact of radionactivity on the evolution of the universe. We demonstrate that whether the radion overcloses the universe, constitutes the dark matter, is the inflaton, the curvaton, or does not play any role in cosmology, depends crucially on the ratio between the energy densities stored in the radion and in the inflaton at the time of inflation. We discuss the general difficulties reconciling models with low compactification scale (i.e., TeV scale) with the simple picture of inflation.

  14. Constraints on the size of the extra dimension from KK gravitinos decay

    Energy Technology Data Exchange (ETDEWEB)

    Gherson, David [Institut de Physique Nucleaire de Lyon (IPNL), Universite Claude Bernard Lyon-I, Villeurbanne (France)

    2007-07-01

    We study the consequences of the gravitino decay into dark matter. We suppose that the lightest neutralino is the main component of dark matter. In our framework gravitino is heavy enough to decay before Big Bang Nucleosynthesis starts. We consider a model coming from a five dimensional supergravity compactified on S{sup 1}/Z{sub 2} with gravity in the bulk and matter localized on tension-less branes at the orbifold fixed points. We require that the dark matter, which is produced thermally and in the decay of Kaluza-Klein modes of gravitino, has an abundance compatible with observation. We deduce from our model that there are curves of constraints between the size of the extra-dimension and the reheating temperature of the universe after inflation. (author)

  15. Two Component Dark Matters in S_4 x Z_2 Flavor Symmetric Extra U(1) Model

    CERN Document Server

    Daikoku, Yasuhiro; Toma, Takashi

    2011-01-01

    We study cosmic-ray anomaly observed by PAMELA based on E_6 inspired extra U(1) model with S_4 x Z_2 flavor symmetry. In our model, the lightest flavon has very long lifetime of O(10^{18)) second which is longer than the age of the universe, but not long enough to explain the PAMELA result ~ O(10^{26}) sec. Such a situation could be avoidable by considering that the flavon is not the dominant component of dark matters and the dominant one is the lightest neutralino. With appropriate parameter set, density parameter of dark matter and over-abundance of positron flux in cosmic-ray are realized at the same time. There is interesting correlation between spectrum of positron flux and V_{MNS}. No excess of anti-proton in cosmic-ray suggests that sfermions are heavier than 4 TeV and the masses of the light Higgs bosons are degenerated.

  16. Warped Geometry in Higher Dimensions with an Orbifold Extra Dimension

    CERN Document Server

    Ito, M

    2001-01-01

    We solve the Einstein equations in higher dimensions with warped geometry where an extra dimension is assumed to have orbifold symmetry, $S^{1}/Z_{2}$. The setup we consider here is an extension to (5+D)-dimensions of the 5-dimensional Randall-Sundrum model, and two hidden brane and observable brane are fixed on orbifold. Anisotropic cosmological constant on each brane with (4+D)-dimensional spacetime is assumed, and the warped metric of 4-dimensions is generally different from one of extra D-dimensions. It is pointed out that the form of metric depends on both the sign of bulk cosmological constant and initial condition of brane world. Furthermore, anisotropic cosmological constant on each brane can be realized due to the presence of brane.

  17. Epidemiology of extra-articular manifestations in rheumatoid arthritis.

    Science.gov (United States)

    Turesson, C; Jacobsson, L T H

    2004-01-01

    Extra-articular RA (ExRA) includes a wide variety of disease manifestations. Although rheumatologists in general are aware that such events are clinically important, the heterogeneity of available data, including discrepancies in case definitions, has complicated constructive discussions on this aspect of the RA disease phenotype. In recent years, there has been a growing recognition of the importance of co-morbidity in patients with RA. ExRA manifestations are not uncommon, explain excess mortality in RA and are predicted by smoking and autoantibodies. Further studies of the mechanisms underlying these associations are likely to be important in improving our understanding of the systemic nature of RA. This article discusses the methodological issues involved in the study of ExRA manifestations, presents suggested criteria that have been used in clinical studies, and reviews important surveys of the epidemiology of extra-articular RA.

  18. AdS/CFT in Virtual Extra Dimension

    CERN Document Server

    Dolce, Donatello

    2011-01-01

    The Lorentz invariant formalism of compact space-time dimensions with periodic boundary conditions provides a semi-classical quantization method in field theory. As shown in [arXiv:0903.3680], the Feynman path integral can be retrieved in terms of the interference between classical paths with different winding numbers. In this paper it is shown that such a purely four-dimensional field theory is manifestly dual to an extra-dimensional field theory. The resulting correspondence between extra-dimensional field theory and ordinary quantum field theory can be interpreted in terms of AdS/CFT phenomenology. In fact, the relativistic geometrodynamics of the boundary encodes the kinematical information of a particle and can be used to formalize interactions, similarly to linearized gravity. By applying this idea to a simple Quark-Gluon-Plasma freeze-out model, we obtain an analogy with basic aspects of AdS/QCD.

  19. A review on models for count data with extra zeros

    Science.gov (United States)

    Zamri, Nik Sarah Nik; Zamzuri, Zamira Hasanah

    2017-04-01

    Typically, the zero inflated models are usually used in modelling count data with excess zeros. The existence of the extra zeros could be structural zeros or random which occur by chance. These types of data are commonly found in various disciplines such as finance, insurance, biomedical, econometrical, ecology, and health sciences. As found in the literature, the most popular zero inflated models used are zero inflated Poisson and zero inflated negative binomial. Recently, more complex models have been developed to account for overdispersion and unobserved heterogeneity. In addition, more extended distributions are also considered in modelling data with this feature. In this paper, we review related literature, provide a recent development and summary on models for count data with extra zeros.

  20. Higher-Dimensional Unified Theories with Fuzzy Extra Dimensions

    Directory of Open Access Journals (Sweden)

    Athanasios Chatzistavrakidis

    2010-08-01

    Full Text Available Theories defined in higher than four dimensions have been used in various frameworks and have a long and interesting history. Here we review certain attempts, developed over the last years, towards the construction of unified particle physics models in the context of higher-dimensional gauge theories with non-commutative extra dimensions. These ideas have been developed in two complementary ways, namely (i starting with a higher-dimensional gauge theory and dimensionally reducing it to four dimensions over fuzzy internal spaces and (ii starting with a four-dimensional, renormalizable gauge theory and dynamically generating fuzzy extra dimensions. We describe the above approaches and moreover we discuss the inclusion of fermions and the construction of realistic chiral theories in this context.

  1. Higher-Dimensional Unified Theories with Fuzzy Extra Dimensions

    CERN Document Server

    Chatzistavrakidis, Athanasios; 10.3842/SIGMA.2010.063

    2010-01-01

    Theories defined in higher than four dimensions have been used in various frameworks and have a long and interesting history. Here we review certain attempts, developed over the last years, towards the construction of unified particle physics models in the context of higher-dimensional gauge theories with non-commutative extra dimensions. These ideas have been developed in two complementary ways, namely (i) starting with a higher-dimensional gauge theory and dimensionally reducing it to four dimensions over fuzzy internal spaces and (ii) starting with a four-dimensional, renormalizable gauge theory and dynamically generating fuzzy extra dimensions. We describe the above approaches and moreover we discuss the inclusion of fermions and the construction of realistic chiral theories in this context.

  2. Extra-pulmonary Pneumocystis jiroveciinfection: a case report

    Directory of Open Access Journals (Sweden)

    Mehrdad Bakhshayesh Karam

    2014-12-01

    Full Text Available In physical examination abdominal tenderness, gate disturbance and penile herpetic lesions were detected. Decreased disc height at T11-T12 level was detected in chest X-ray. Abdominal sonography and CT scan revealed hypo dense lesions in Lt left Lobe of liver and multiple hypo dense splenic and pancreatic lesions, ascitis, Lt left sided pleural effusion, thickening of jejuneal mucosa and edema of bowel wall. Vertebral body lesion and paravertebral abscess, bony calvarial involvement and adjacent extra axial brain lesion were observed in imaging were other findings. RNA analysis for HIV was positive. Vertebral lesion biopsy and aspiration of splenic lesion were performed and pathology revealed Pneumocystis jirovecii suggestive of extra pulmonary Pneumocystis carinii infection.

  3. CP phase from twisted Higgs VEV in extra dimension

    CERN Document Server

    Fujimoto, Yukihiro; Sakamoto, Makoto

    2013-01-01

    We propose a new mechanism for generating CP phase via Higgs vacuum expectation value originating from geometry of an extra dimension. Allowing a twisted boundary condition for the Higgs doublet drives us into an extra-dimension-coordinate-dependent vacuum expectation value containing a CP phase degree of freedom. With this mechanism, we construct a phenomenological model on S1 which can simultaneously and naturally explain the origin of fermion generation, quark mass hierarchy, and the structure of the Cabibbo-Kobayashi-Maskawa matrix with the CP phase. By introducing point interactions, which are additional boundary points on S1, the 5D quarks realize the three generations. Our situation is phenomenologically-preferred one since all the flavor structures are realized with good precision and almost all dimensionless scaled parameters take values of natural O(10) magnitudes. An almost exponential vacuum expectation value profile of a scalar singlet, which appears in the Yukawa sector, helps the naturalness in...

  4. Yukawa Hierarchies From Extra Dimensions With Small FCNC

    CERN Document Server

    Lillie, Benjamin Huntington

    2003-01-01

    We investigate a class of extra dimensional models where all of the Standard Model fermions are localized to a single fixed point in an $S_1/Z_2$ orbifold, and each species is localized with an exponential wavefunction with a different width. We show that this naturally generates Yukawa hierarchies of the size present in the Standard Model, and we find a set of model parameters that reproduces the observed masses and mixings to experimental accuracy. In addition, the dominant constraints, arising from flavor changing neutral currents, are shown to restrict the compactification scale to be $1/R \\ge 2-5 \\tev$, which is a much less stringent constraint than in similar extra dimensional models of the Yukawa hierarchy.

  5. Dust and molecules in extra-galactic planetary nebulae

    CERN Document Server

    Garcia-Hernandez, D A

    2015-01-01

    Extra-galactic planetary nebulae (PNe) permit the study of dust and molecules in metallicity environments other than the Galaxy. Their known distances lower the number of free parameters in the observations vs. models comparison, providing strong constraints on the gas-phase and solid-state astrochemistry models. Observations of PNe in the Galaxy and other Local Group galaxies such as the Magellanic Clouds (MC) provide evidence that metallicity affects the production of dust as well as the formation of complex organic molecules and inorganic solid-state compounds in their circumstellar envelopes. In particular, the lower metallicity MC environments seem to be less favorable to dust production and the frequency of carbonaceous dust features and complex fullerene molecules is generally higher with decreasing metallicity. Here, I present an observational review of the dust and molecular content in extra-galactic PNe as compared to their higher metallicity Galactic counterparts. A special attention is given to th...

  6. Retroperitoneal extra-adrenal paraganglioma: a rare but important diagnosis.

    LENUS (Irish Health Repository)

    Ahmad, S

    2012-01-31

    BACKGROUND: Extra-adrenal paragangliomas of the retroperitonium are infrequently diagnosed. Their malignant behaviour cannot be predicted on initial clinical and histological assessment. These tumours have higher propensity for subsequent metastasis compared with pargangliomas at other sites. AIM: We aim to describe a case report of an incidental finding of left retroperitoneal paraganglioma in a young man who presented with right flank pain. We also aim to emphasize the importance of diagnosis and the malignant potential of these tumours. METHOD: Patient\\'s clinical notes, operative findings, imaging studies and laboratory investigations including histology results were reviewed. A literature search was done to look into the incidence, presentation, follow-up plan and treatment options for these tumours. CONCLUSION: Surgical resection is the only available curative option for extra-adrenal paragangliomas. Metastasis is observed years after surgery, hence long-term follow-up is required.

  7. Constraining Extra Space Dimensions using Precision Molecular Spectroscopy

    CERN Document Server

    Gato-Rivera, Beatriz

    2015-01-01

    Highly accurate measurements of quantum level energies in molecular systems provide a test ground for new physics, as such effects could manifest themselves as minute shifts in the quantum level structures of atoms and molecules. For the lightest molecular systems, neutral molecular hydrogen (H$_2$, HD and D$_2$) and the molecular hydrogen ions (H$_2^+$, HD$^+$ and D$_2^+$), weak force effects are several orders weaker than current experimental and theoretical results, while contributions of Newtonian gravity and the strong force at the characteristic molecular distance scale of 1 \\AA\\ can be safely neglected. Comparisons between experiment and QED calculations for these molecular systems can be interpreted in terms of probing large extra space dimensions, under which gravity could become much stronger than in ordinary 3-D space. Under this assumption, using the spectra of H$_2$ we have derived constraints on the compactification scales for extra dimensions within the Arkani-Hamed-Dimopoulos-Dvali (ADD) frame...

  8. Development and decay of extra-linguistic communication.

    Science.gov (United States)

    Bara, B G; Bucciarelli, M; Geminiani, G C

    2000-01-01

    Cognitive Pragmatics theory is concerned with analyzing the cognitive processes underlying communication. In previous works we have explained the emergence of communication in context, as revealed by very young children, and the communicative deficits shown by closed head injury patients. The aim of the present work is an extension of Cognitive Pragmatics to the emergence and the decay of extra-linguistic communication. In particular, we investigate the performance of 2- to 7-year-old children and that of Alzheimer's patients in standard and nonstandard (irony and deceit) pragmatic tasks. The predictions derived by Cognitive Pragmatics are confirmed. Comprehension of pragmatic phenomena which are more complex according to the theory emerges later in the development (Experiment 1), and their decay is most severe in Alzheimer's patients (Experiment 2). We conclude that the framework provided by Cognitive Pragmatics can accommodate both the development and the decay of extra-linguistic communication.

  9. Radiologic manifestations of extra-cardiac complications of infective endocarditis

    Energy Technology Data Exchange (ETDEWEB)

    Colen, Teran W.; Gunn, Martin; Cook, Erin; Dubinsky, Theodore [University of Washington Medical Center, Department of Radiology, 1959 NE Pacific Ave, Box 357115, Seattle, WA (United States)

    2008-11-15

    Infective endocarditis (IE) is a disease with high morbidity and a mortality rate of 9-30%, even with appropriate diagnosis and therapy. Septic emboli, caused by IE, can affect any organ or tissue in the body with an arterial supply and occur in 12-40% of IE cases. The most common extra-cardiac organ system involved in IE is the central nervous system. Other organs frequently involved are the lungs (especially in right-sided IE), spleen, kidneys, liver, and the musculoskeletal system. In addition, the arterial system itself is susceptible to the development of potentially fatal mycotic aneurysms. As extra-cardiac complications often antedate the clinical diagnosis of IE, it is important that the diagnosis is suggested when characteristic findings are encountered during imaging. In addition, imaging is often used to monitor the extent of complications in patients with a known diagnosis of IE. (orig.)

  10. Large extra dimensions, sterile neutrinos and solar neutrino data.

    Science.gov (United States)

    Caldwell, D O; Mohapatra, R N; Yellin, S J

    2001-07-23

    Solar, atmospheric, and LSND neutrino oscillation results require a light sterile neutrino, nu(B), which can exist in the bulk of extra dimensions. Solar nu(e), confined to the brane, can oscillate in the vacuum to the zero mode of nu(B) and via successive Mikheyev-Smirnov-Wolfenstein transitions to Kaluza-Klein states of nu(B). This new way to fit solar data is provided by both low and intermediate string scale models. From average rates seen in the three types of solar experiments, the Super-Kamiokande spectrum is predicted with 73% probability, but dips characteristic of the 0.06 mm extra dimension should be seen in the SNO spectrum.

  11. Newton's law in braneworlds with an infinite extra dimension

    CERN Document Server

    Ito, M

    2002-01-01

    We study the behavior of the four$-$dimensional Newton's law in warped braneworlds. The setup considered here is a $(3+n)$-brane embedded in $(5+n)$ dimensions, where $n$ extra dimensions are compactified and a dimension is infinite. We show that the wave function of gravity is described in terms of the Bessel functions of $(2+n/2)$-order and that estimate the correction to Newton's law. In particular, the Newton's law for $n=1$ can be exactly obtained.

  12. Detecting the polarization signatures of extra-solar planets

    Science.gov (United States)

    Hough, J. H.; Lucas, P. W.; Bailey, J. A.; Tamura, M.; Hirst, E.

    2006-06-01

    Direct detection of the light scattered from extra-solar planets is important in establishing the planet's mass, radius, albedo and nature of the particles in the planetary atmosphere. We describe, and present results from, a new optical polarimeter (PlanetPol) designed to reach fractional polarizations of 10 -6 or better from ground-based telescopes, necessary to detect the polarization signature of unresolved hot-Jupiters.

  13. Tom Bissel, Voglia di vincere/Extra Lives

    Directory of Open Access Journals (Sweden)

    Ambra Agnoletto

    2013-03-01

    Full Text Available Leggere il libro di Tom Bissell Extra lives: Why Video Games Matter, tradotto in Italia con il titolo Voglia di vincere, è stata un’impresa. L’impresa di qualcuno abituato a muoversi in ambito cinematografico e musicale, ma che affronta con l’entusiasmo e le incertezze del neofita i videogames e tutto ciò che riguarda la sfera videoludica, nei suoi aspetti creativi, estetici, di design e meccanica di gioco.

  14. Lymphomas and metastases of the extra-ocular musculature

    Energy Technology Data Exchange (ETDEWEB)

    Surov, Alexey; Behrmann, Curd; Koesling, Sabrina [Martin Luther University of Halle-Wittenberg, Department of Radiology, Halle (Germany); Holzhausen, Hans-Juergen [Martin Luther University of Halle-Wittenberg, Department of Pathology, Halle (Germany)

    2011-11-15

    The involvement of extra-ocular muscles in malignant diseases has been described only sporadically. The purpose of this study was to estimate the prevalence of orbital muscle lymphoma and metastases and to analyse their radiological findings. In the time period from January 2000 to January 2010, 11 patients with extra-ocular muscle malignancies (EOMM) were retrospectively identified in the radiological database of our institution. There were four women and seven men with a median age of 58 years (range, 47 to 72 years). In three patients non-Hodgkin lymphoma (NHL), in seven cases intramuscular metastases of solid tumours and in one patient plasmacytoma of orbital muscles were diagnosed. In all, magnetic resonance imaging (MRI) was performed on 11 patients using a 1.5-T MRI scanner (Magnetom Vision Sonata Upgrade, Siemens, Germany). The diagnosis of EOMM was confirmed histopathologically by muscle biopsy in all cases. The prevalence of orbital muscle involvement in plasmacytoma was 0.3%, in NHL 0.4% and in carcinomas 0.1%. Clinically, EOMM presented as painless proptosis and motility disturbance. Medial and lateral rectus muscles were involved in most patients. On T2-weighted images, the lesions were isointense or mixed iso-to-hyperintense in comparison to the unaffected musculature. On T1-weighted images, all tumours were homogeneously isointense. After intravenous administration of contrast medium, most lesions showed moderate heterogeneous enhancement. Lymphomas and metastases are rare lesions of the extra-ocular musculature with a prevalence below 0.5%. Their radiological and clinical signs are non-specific and include painless muscle enlargement or masses. They should be considered in the differential diagnosis of diseases of extra-ocular muscles. (orig.)

  15. Extra-intracranial standard bypass in the elderly

    DEFF Research Database (Denmark)

    Sandow, Nora; von Weitzel-Mudersbach, Paul; Rosenbaum, Sverre;

    2013-01-01

    Patients with chronic atherosclerotic vessel occlusion and cerebrovascular hemodynamic insufficiency may benefit from extra-intracranial (EC-IC) bypass surgery. Due to demographic changes, an increasing number of elderly patients presents with cerebrovascular hemodynamic insufficiency. So far......, little data for EC-IC bypass surgery in elderly patients suffering occlusive cerebrovascular disease are available. We therefore designed a retrospective study to address the question whether EC-IC bypass is a safe and efficient treatment in a patient cohort ≥70 years....

  16. Experimental Signatures of Split Fermions in Extra Dimensions

    OpenAIRE

    Grossman, Yuval

    2000-01-01

    The smallness and hierarchy of the fermion parameters could be explained in theories with extra dimensions where doublets and singlets are localized at slightly separated points. Scattering cross sections for collisions of such fermions vanish exponentially at energies high enough to probe the separation distance. This is because the separation puts a lower bound on the attainable impact parameter in the collision. The NLC, and in particular the combination of the e^+e^- and e^-e^- modes, can...

  17. Search for Extra Dimensions with the CMS Detector

    CERN Document Server

    Shmatov, Sergei

    2008-01-01

    Multidimensional theories at TeV energies, as given in the brane world scenarios with large or compact extra spatial dimensions (ED), are discussed. One interesting feature of recent ED models is the rich low-energy phenomenology that originates from the Kaluza-Klein spectrum of various particles propagating in ED. A series of searches is addressed in the CMS experiment with different signatures.

  18. Searches for Dark Matter and Extra Dimensions at the LHC

    CERN Document Server

    Demiragli, Z

    2015-01-01

    The $CMS^1$ and $ATLAS^2$ collaborations at the Large Hadron Coltider have collected approx­ imately $20fb^{-1}$ of pp collision data with center-of-mass energy of 8 TeV and have performed targeted searches for Dark Matter and Extra Dimensions. No significant deviations from the standard model prediction have been observed. A summary of the latest experimental results is presented here.

  19. Achieving More with Less: Extra Milers’ Behavioral Influences in Teams

    OpenAIRE

    Li, N.; Zhao, H; Walter, SL; Zhang, X; J. Yu

    2015-01-01

    Teams are composed of individual members who collectively contribute to team success. As a result, contemporary team research tends to focus on how team overall properties (e.g., the average of team personality and behavior) affect team processes and effectiveness while overlooking the potential unique influences of specific members on team outcomes. Drawing on minority influence theory (Grant & Patil, 2012), we extend previous teams research by demonstrating that an extra miler (i.e., a team...

  20. Extra-intestinal coccidiosis in the kiwi (Apteryx spp.).

    Science.gov (United States)

    Morgan, Kerri J; Alley, Maurice R; Pomroy, William E; Gartrell, Brett D; Castro, Isabel; Howe, Laryssa

    2013-04-01

    Despite significant conservation intervention, the kiwi (Apteryx spp.) is in serious population decline. To increase survival in the wild, conservation management includes rearing of young birds in captivity, safe from introduced mammalian predators. However, an increase in density of immunologically naïve kiwi increases the risk of exposure to disease, including coccidia. Intestinal coccidiosis has recently been described in the kiwi, and although extra-intestinal coccidiosis was first recognized in kiwi in 1978, very little is known about this disease entity. This study used archived histological tissues and reports from routine necropsies to describe the pathology of naturally occurring extra-intestinal coccidiosis. At least 4.5% of all kiwi necropsied during 1991 to 2011 (n=558) were affected by extra-intestinal coccidiosis, and it is estimated that it caused death in 0.9 to 1.2% of kiwi in the study group. Four forms were recognized: renal, hepatic, and, less commonly, splenic and pulmonary. At necropsy, renal coccidiosis was associated with miliary white streaks and foci through the kidneys, renomegaly, and renal pallor or congestion. Renal meronts and gametocytes were confined to the distal convoluted tubules and collecting ducts, and were associated with renal tubular necrosis and tubular obstruction. Hepatic miliary pinpoint foci were present throughout the hepatic parenchyma associated microscopically with macromeronts measuring 304×227 µm. In two cases, clusters of splenic meronts were identified, and a similar lesion was identified in the pulmonary interstitium of another case. Juvenile, captive kiwi were most often affected with extra-intestinal coccidiosis, illustrating an increased expression of disease with population manipulation for conservation purposes.

  1. CERN gives Higgs hunters extra month to collect data

    CERN Multimedia

    Morton, O

    2000-01-01

    In August, scientists working on LEP's ALEPH dectector saw signs that the accelerator might be producing Higgs bosons. A reanalysis of data from DELPHI flagged something similar there. As a result LEP is to continue operating for an extra month to try and verify the results. After that though the accelerator must close to prevent unacceptable delays in the construction of the LHC, scheduled to start up in summer 2005 (2 pages).

  2. Kaluza theory with zero-length extra dimensions

    CERN Document Server

    Stoica, Ovidiu Cristinel

    2016-01-01

    A new approach to the Kaluza theory and its relation to the gauge theory is presented. Two degenerate metrics on the $4+d$-dimensional total manifold are used, one corresponding to the spacetime metric and giving the fiber of the gauge bundle, and the other one to the metric of the fiber and giving the horizontal bundle of the connection. When combined, the two metrics give the Kaluza metric and its generalization to the non-abelian case, justifying thus his choice. Considering the two metrics as fundamental rather than the Kaluza metric explains why Kaluza's theory should not be regarded as five-dimensional vacuum gravity. This approach suggests that the only evidence of extra dimensions is given by the existence of the gauge forces, explaining thus why other kinds of evidence are not available. In addition, because the degenerate metric corresponding to the spacetime metric vanishes along the extra dimensions, the lengths in the extra dimensions is zero, preventing us to directly probe them. Therefore this ...

  3. XQCAT eXtra Quark Combined Analysis Tool

    CERN Document Server

    Barducci, D; Buchkremer, M; Marrouche, J; Moretti, S; Panizzi, L

    2015-01-01

    XQCAT (eXtra Quark Combined Analysis Tool) is a tool aimed to determine exclusion Confidence Levels (eCLs) for scenarios of new physics characterised by the presence of one or multiple heavy extra quarks (XQ) which interact through Yukawa couplings with any of the Standard Model (SM) quarks. The code uses a database of efficiencies for pre-simulated processes of Quantum Chromo-Dynamics (QCD) pair production and on-shell decays of extra quarks. In the version 1.0 of XQCAT the efficiencies have been computed for a set of seven publicly available search results by the CMS experiment, and the package is subject to future updates to include further searches by both ATLAS and CMS collaborations. The input for the code is a text file in which masses, branching ratios (BRs) and dominant chirality of the couplings of the new quarks are provided. The output of the code is the eCL of the test point for each implemented experimental analysis considered individually and, when possible, in statistical combination.

  4. Extra-gonadal sites of estrogen biosynthesis and function.

    Science.gov (United States)

    Barakat, Radwa; Oakley, Oliver; Kim, Heehyen; Jin, Jooyoung; Ko, CheMyong Jay

    2016-09-01

    Estrogens are the key hormones regulating the development and function of reproductive organs in all vertebrates. Recent evidence indicates that estrogens play important roles in the immune system, cancer development, and other critical biological processes related to human well-being. Obviously, the gonads (ovary and testis) are the primary sites of estrogen synthesis, but estrogens synthesized in extra- gonadal sites play an equally important role in controlling biological activities. Understanding non-gonadal sites of estrogen synthesis and function is crucial and will lead to therapeutic interventions targeting estrogen signaling in disease prevention and treatment. Developing a rationale targeting strategy remains challenging because knowledge of extra-gonadal biosynthesis of estrogens, and the mechanism by which estrogen activity is exerted, is very limited. In this review, we will summarize recent discoveries of extra-gonadal sites of estrogen biosynthesis and their local functions and discuss the significance of the most recent novel discovery of intestinal estrogen biosynthesis. [BMB Reports 2016; 49(9): 488-496].

  5. Deciphering causal and statistical relations of molecular aberrations and gene expressions in NCI-60 cell lines

    Directory of Open Access Journals (Sweden)

    Li Shyh-Dar

    2011-11-01

    Full Text Available Abstract Background Cancer cells harbor a large number of molecular alterations such as mutations, amplifications and deletions on DNA sequences and epigenetic changes on DNA methylations. These aberrations may dysregulate gene expressions, which in turn drive the malignancy of tumors. Deciphering the causal and statistical relations of molecular aberrations and gene expressions is critical for understanding the molecular mechanisms of clinical phenotypes. Results In this work, we proposed a computational method to reconstruct association modules containing driver aberrations, passenger mRNA or microRNA expressions, and putative regulators that mediate the effects from drivers to passengers. By applying the module-finding algorithm to the integrated datasets of NCI-60 cancer cell lines, we found that gene expressions were driven by diverse molecular aberrations including chromosomal segments' copy number variations, gene mutations and DNA methylations, microRNA expressions, and the expressions of transcription factors. In-silico validation indicated that passenger genes were enriched with the regulator binding motifs, functional categories or pathways where the drivers were involved, and co-citations with the driver/regulator genes. Moreover, 6 of 11 predicted MYB targets were down-regulated in an MYB-siRNA treated leukemia cell line. In addition, microRNA expressions were driven by distinct mechanisms from mRNA expressions. Conclusions The results provide rich mechanistic information regarding molecular aberrations and gene expressions in cancer genomes. This kind of integrative analysis will become an important tool for the diagnosis and treatment of cancer in the era of personalized medicine.

  6. Perspectives on deciphering mechanisms underlying plant heat stress response and thermotolerance

    Directory of Open Access Journals (Sweden)

    Kamila Lucia Bokszczanin

    2013-08-01

    Full Text Available Global warming is a major threat for agriculture and food safety and in many cases the negative effects are already apparent. The current challenge of basic and applied plant science is to decipher the molecular mechanisms of heat stress response and thermotolerance in detail and use this information to identify genotypes that will withstand unfavorable environmental conditions. Nowadays X-omics approaches complement the findings of previous targeted studies and highlight the complexity of heat stress response mechanisms giving information for so far unrecognized genes, proteins and metabolites as potential key players of thermotolerance. Even more, roles of epigenetic mechanisms and the involvement of small RNAs in thermotolerance are currently emerging and thus open new directions of yet unexplored areas of plant heat stress response. In parallel it is emerging that although the whole plant is vulnerable to heat, specific organs are particularly sensitive to elevated temperatures. This has redirected research from the vegetative to generative tissues. The sexual reproduction phase is considered as the most sensitive to heat and specifically pollen exhibits the highest sensitivity and frequently an elevation of the temperature just a few degrees above the optimum during pollen development can have detrimental effects for crop production. Compared to our knowledge on heat stress response of vegetative tissues, the information on pollen is still scarce. Nowadays, several techniques for high-throughput X-omics approaches provide major tools to explore the principles of pollen heat stress response and thermotolerance mechanisms in specific genotypes. The collection of such information will provide an excellent support for improvement of breeding programs to facilitate the development of tolerant cultivars. The review aims at describing the current knowledge of thermotolerance mechanisms and the technical advances which will foster new insights into

  7. Deciphering the Role of Emx1 in Neurogenesis: A Neuroproteomics Approach

    Science.gov (United States)

    Kobeissy, Firas H.; Hansen, Katharina; Neumann, Melanie; Fu, Shuping; Jin, Kulin; Liu, Jialing

    2016-01-01

    Emx1 has long been implicated in embryonic brain development. Previously we found that mice null of Emx1 gene had smaller dentate gyri and reduced neurogenesis, although the molecular mechanisms underlying this defect was not well understood. To decipher the role of Emx1 gene in neural regeneration and the timing of its involvement, we determine the frequency of neural stem cells (NSCs) in embryonic and adult forebrains of Emx1 wild type (WT) and knock out (KO) mice in the neurosphere assay. Emx1 gene deletion reduced the frequency and self-renewal capacity of NSCs of the embryonic brain but did not affect neuronal or glial differentiation. Emx1 KO NSCs also exhibited a reduced migratory capacity in response to serum or vascular endothelial growth factor (VEGF) in the Boyden chamber migration assay compared to their WT counterparts. A thorough comparison between NSC lysates from Emx1 WT and KO mice utilizing 2D-PAGE coupled with tandem mass spectrometry revealed 38 proteins differentially expressed between genotypes, including the F-actin depolymerization factor Cofilin. A global systems biology and cluster analysis identified several potential mechanisms and cellular pathways implicated in altered neurogenesis, all involving Cofilin1. Protein interaction network maps with functional enrichment analysis further indicated that the differentially expressed proteins participated in neural-specific functions including brain development, axonal guidance, synaptic transmission, neurogenesis, and hippocampal morphology, with VEGF as the upstream regulator intertwined with Cofilin1 and Emx1. Functional validation analysis indicated that apart from the overall reduced level of phosphorylated Cofilin1 (p-Cofilin1) in the Emx1 KO NSCs compared to WT NSCs as demonstrated in the western blot analysis, VEGF was able to induce more Cofilin1 phosphorylation and FLK expression only in the latter. Our results suggest that a defect in Cofilin1 phosphorylation induced by VEGF or other

  8. The Use of Animal Models to Decipher Physiological and Neurobiological Alterations of Anorexia Nervosa Patients

    Science.gov (United States)

    Méquinion, Mathieu; Chauveau, Christophe; Viltart, Odile

    2015-01-01

    Extensive studies were performed to decipher the mechanisms regulating feeding due to the worldwide obesity pandemy and its complications. The data obtained might be adapted to another disorder related to alteration of food intake, the restrictive anorexia nervosa. This multifactorial disease with a complex and unknown etiology is considered as an awful eating disorder since the chronic refusal to eat leads to severe, and sometimes, irreversible complications for the whole organism, until death. There is an urgent need to better understand the different aspects of the disease to develop novel approaches complementary to the usual psychological therapies. For this purpose, the use of pertinent animal models becomes a necessity. We present here the various rodent models described in the literature that might be used to dissect central and peripheral mechanisms involved in the adaptation to deficient energy supplies and/or the maintenance of physiological alterations on the long term. Data obtained from the spontaneous or engineered genetic models permit to better apprehend the implication of one signaling system (hormone, neuropeptide, neurotransmitter) in the development of several symptoms observed in anorexia nervosa. As example, mutations in the ghrelin, serotonin, dopamine pathways lead to alterations that mimic the phenotype, but compensatory mechanisms often occur rendering necessary the use of more selective gene strategies. Until now, environmental animal models based on one or several inducing factors like diet restriction, stress, or physical activity mimicked more extensively central and peripheral alterations decribed in anorexia nervosa. They bring significant data on feeding behavior, energy expenditure, and central circuit alterations. Animal models are described and criticized on the basis of the criteria of validity for anorexia nervosa. PMID:26042085

  9. Orthogonal array deciphering MRS medium requirements for isolated Lactobacillus rhamnosus ZY with cell properties characterization.

    Science.gov (United States)

    Zhang, Yu; Ng, I-Son; Yao, Chuanyi; Lu, Yinghua

    2014-09-01

    Lactobacillus rhamnosus is a well-known lactic acid bacterium (LAB), but a new ZY strain was isolated for the first time from commercial probiotic powder recently. Although many studies have focused on developing cost-effective media for the production of LAB, the de Man, Rogosa and Sharpe (MRS) medium is still the most common medium for bioprocesses. The aim of the current study is to decipher the composition of MRS based on a statistical approach, which will allow a higher biomass of Lactobacillus to be obtained. In Taguchi's approach, an L27 orthogonal array was adopted to evaluate the significance of 10 ingredients in MRS, in which the effects of the components were ranked according to their effect on biomass at OD600 as dextrose > MnSO4·H2O > beef extract > CH3COONa > MgSO4 > yeast extract > proteose peptone > K2HPO4 > ammonium citrate > Tween 80. Although the individual trace elements of ammonium citrate, K2HPO4, CH3COONa and MgSO4 in MRS had an insignificant influence on the biomass after statistical analysis, the total elimination of trace elements would predominantly affect the cell growth of Lactobacillus. Further characterization of the cell properties through attenuated total reflectance of Fourier transform infrared (ATR-FTIR) spectroscopy and protein identification via SDS-PAGE coupled with tandem mass spectrometry implied that dextrose as major carbon source in MRS played the most crucial role for L. rhamnosus production. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  10. Deciphering composition and function of the root microbiome of a legume plant.

    Science.gov (United States)

    Hartman, Kyle; van der Heijden, Marcel Ga; Roussely-Provent, Valexia; Walser, Jean-Claude; Schlaeppi, Klaus

    2017-01-17

    Diverse assemblages of microbes colonize plant roots and collectively function as a microbiome. Earlier work has characterized the root microbiomes of numerous plant species, but little information is available for legumes despite their key role in numerous ecosystems including agricultural systems. Legumes form a root nodule symbiosis with nitrogen-fixing Rhizobia bacteria and thereby account for large, natural nitrogen inputs into soils. Here, we describe the root bacteria microbiome of the legume Trifolium pratense combining culture-dependent and independent methods. For a functional understanding of individual microbiome members and their impact on plant growth, we began to inoculate root microbiome members alone or in combination to Trifolium roots. At a whole-root scale, Rhizobia bacteria accounted for ~70% of the root microbiome. Other enriched members included bacteria from the genera Pantoea, Sphingomonas, Novosphingobium, and Pelomonas. We built a reference stock of 200 bacteria isolates, and we found that they corresponded to ~20% of the abundant root microbiome members. We developed a microcosm system to conduct simplified microbiota inoculation experiments with plants. We observed that while an abundant root microbiome member reduced plant growth when inoculated alone, this negative effect was alleviated if this Flavobacterium was co-inoculated with other root microbiome members. The Trifolium root microbiome was dominated by nutrient-providing Rhizobia bacteria and enriched for bacteria from genera that may provide disease protection. First microbiota inoculation experiments indicated that individual community members can have plant growth compromising activities without being apparently pathogenic, and a more diverse root community can alleviate plant growth compromising activities of its individual members. A trait-based characterization of the reference stock bacteria will permit future microbiota manipulation experiments to decipher overall

  11. Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.

    Directory of Open Access Journals (Sweden)

    Liliana Batista-Nascimento

    Full Text Available Heat shock transcription factor 1 (HSF1 plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that include protein acetylation, sumoylation and phosphorylation. Upon exposure to stress HSF1 homotrimerizes, accumulates in nucleus, binds DNA, becomes hyper-phosphorylated and activates the expression of stress response genes. While HSF1 and the mechanisms that regulate its activity have been studied for over two decades, our understanding of HSF1 regulation remains incomplete. As previous studies have shown that HSF1 and the heat shock response promoter element (HSE are generally structurally conserved from yeast to metazoans, we have made use of the genetically tractable budding yeast as a facile assay system to further understand the mechanisms that regulate human HSF1 through phosphorylation of serine 303. We show that when human HSF1 is expressed in yeast its phosphorylation at S303 is promoted by the MAP-kinase Slt2 independent of a priming event at S307 previously believed to be a prerequisite. Furthermore, we show that phosphorylation at S303 in yeast and mammalian cells occurs independent of GSK3, the kinase primarily thought to be responsible for S303 phosphorylation. Lastly, while previous studies have suggested that S303 phosphorylation represses HSF1-dependent transactivation, we now show that S303 phosphorylation also represses HSF1 multimerization in both yeast and mammalian cells. Taken together, these studies suggest that yeast cells will be a powerful experimental tool for deciphering aspects of human HSF1 regulation by post-translational modifications.

  12. Gene tree discordance of wild and cultivated Asian rice deciphered by genome-wide sequence comparison.

    Science.gov (United States)

    Yang, Ching-chia; Sakai, Hiroaki; Numa, Hisataka; Itoh, Takeshi

    2011-05-15

    Although a large number of genes are expected to correctly solve a phylogenetic relationship, inconsistent gene tree topologies have been observed. This conflicting evidence in gene tree topologies, known as gene tree discordance, becomes increasingly important as advanced sequencing technologies produce an enormous amount of sequence information for phylogenomic studies among closely related species. Here, we aim to characterize the gene tree discordance of the Asian cultivated rice Oryza sativa and its progenitor, O. rufipogon, which will be an ideal case study of gene tree discordance. Using genome and cDNA sequences of O. sativa and O. rufipogon, we have conducted the first in-depth analyses of gene tree discordance in Asian rice. Our comparison of full-length cDNA sequences of O. rufipogon with the genome sequences of the japonica and indica cultivars of O. sativa revealed that 60% of the gene trees showed a topology consistent with the expected one, whereas the remaining genes supported significantly different topologies. Moreover, the proportions of the topologies deviated significantly from expectation, suggesting at least one hybridization event between the two subgroups of O. sativa, japonica and indica. In fact, a genome-wide alignment between japonica and indica indicated that significant portions of the indica genome are derived from japonica. In addition, literature concerning the pedigree of the indica cultivar strongly supported the hybridization hypothesis. Our molecular evolutionary analyses deciphered complicated evolutionary processes in closely related species. They also demonstrated the importance of gene tree discordance in the era of high-speed DNA sequencing.

  13. The use of animal models to decipher physiological and neurobiological alterations of Anorexia Nervosa patients.

    Directory of Open Access Journals (Sweden)

    Mathieu eMéquinion

    2015-05-01

    Full Text Available Extensive studies were performed to decipher the mechanisms regulating feeding due to the worldwide obesity pandemy and its complications. The data obtained might be adapted to another disorder related to alteration of food intake, the restrictive anorexia nervosa. This multifactorial disease with a complex and unknown etiology is considered as an awful eating disorder since the chronic refusal to eat leads to severe and sometimes irreversible complications for the whole organism, until death. There is an urgent need to better understand the different aspects of the disease to develop novel approaches complementary to the usual psychological therapies. For this purpose, the use of pertinent animal models becomes a necessity. We present here the various rodent models described in the literature that might be used to dissect central and peripheral mechanisms involved in the adaptation to deficient energy supplies and/or the maintenance of physiological alterations on the long term. Data obtained from the spontaneous or engineered genetic models permit to better apprehend the implication of one signaling system (hormone, neuropeptides, neurotransmitter in the development of several symptoms observed in anorexia nervosa. As example, mutations in the ghrelin, serotonin, dopamine pathways lead to alterations that mimic the phenotype, but compensatory mechanisms often occur rendering necessary the used of more selective gene strategies. Until now, environmental animal models based on one or several inducing factors like diet restriction, stress or physical activity mimicked more extensively central and peripheral alterations decribed in anorexia nervosa. They bring significant data on feeding behavior, energy expenditure and central circuit alterations. Animal models are described and criticized on the basis of the criteria of validity for anorexia nervosa.

  14. A prospective comparison between Kapandji and percutaneous extra-focal fixation in extra articular distal radius fractures.

    Science.gov (United States)

    Mirhamidi, Seyed Mehdi; Bayat, Farzad Merrikh

    2013-01-01

    there are multiple methods of distal radius fractures treatments. Of these percutaneous wire insertion has yielded popular acceptance. These percutaneous wire insertions can be done through many different ways with their own advantages and disadvantages. One of these methods is Kapandji method and because of its inherent stability in biomechanical examinations we suppose that we can begin the range of motion sooner than other methods with the hope of better outcome. From 2010 to 2012 we studied 45 patients, of these 23 went under extra-focal technique and 22 went under Kapandji technique. After Kapandji we immobilized the limb in splint for 4 weeks and started partial motion thereafter and in the extra-focal group we immobilized them in for 6 weeks in long arm casts. After 3 months and 6 months we assess the Gartland and Warley score and find 39% and 73% excellent and good result in extra-focal and 45% and 86% excellent and good result in Kapandji group after 3 and 6 months, respectively. Although there were about 0.22 mm collapse in both groups, here were no statistically significant differences in functional score or radiologic and anatomic parameters between groups. we have find Kapandji technique a suitable method of distal radius fracture fixation in cases with no articular involvement and we think it is better to immobilize the limb for at least 6 weeks after Kapandji fixation, in order to better control the pain.

  15. Multicentric extra-abdominal desmoid tumors arising in bilateral lower limbs

    Directory of Open Access Journals (Sweden)

    Nobuhiro Fukushima

    2010-03-01

    Full Text Available Extra-abdominal desmoid tumors preferentially affect the shoulders, arms, backs, buttocks, and thighs of young adults. Multicentric occurrence is rather rare but seems to be another distinctive feature of extra-abdominal desmoid tumors. In this article we report a rare case of multicentric extra-abdominal desmoid tumors arising in bilateral lower limbs.

  16. 7 CFR 51.881 - U.S. Extra Fancy Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false U.S. Extra Fancy Export. 51.881 Section 51.881 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... U.S. Extra Fancy Export. “U.S. Extra Fancy Export” consists of grapes which meet the...

  17. Extra-Credential Experiences and Social Closure: Working-Class Students at University

    Science.gov (United States)

    Lehmann, Wolfgang

    2012-01-01

    Human capital theorists perceive of educational expansion as beneficial to individuals, corporations and national economies, while social closure theorists have claimed that inflation of credential requirements maintains traditional status inequalities. In this paper I argue that status inequalities are not only maintained by credential inflation,…

  18. Extra-Credential Experiences and Social Closure: Working-Class Students at University

    Science.gov (United States)

    Lehmann, Wolfgang

    2012-01-01

    Human capital theorists perceive of educational expansion as beneficial to individuals, corporations and national economies, while social closure theorists have claimed that inflation of credential requirements maintains traditional status inequalities. In this paper I argue that status inequalities are not only maintained by credential inflation,…

  19. The language of the protein universe.

    Science.gov (United States)

    Scaiewicz, Andrea; Levitt, Michael

    2015-12-01

    Proteins, the main cell machinery which play a major role in nearly every cellular process, have always been a central focus in biology. We live in the post-genomic era, and inferring information from massive data sets is a steadily growing universal challenge. The increasing availability of fully sequenced genomes can be regarded as the 'Rosetta Stone' of the protein universe, allowing the understanding of genomes and their evolution, just as the original Rosetta Stone allowed Champollion to decipher the ancient Egyptian hieroglyphics. In this review, we consider aspects of the protein domain architectures repertoire that are closely related to those of human languages and aim to provide some insights about the language of proteins.

  20. Cosmological evolution in a brane-universe

    CERN Document Server

    Langlois, D

    2002-01-01

    The idea of extra-dimensions has recently gone through a renewal with the hypothesis, suggested by recent developments in string theory, that ordinary matter is confined to a sub-space, called brane, embedded in a higher dimensional spacetime. I summarize here some consequences in cosmology of this type of models. The most remarkable aspect is that the Friedmann laws, which govern the expansion of the Universe, are modified. An important direction of research is the study of cosmological perturbations and the possible signature of extra-dimensions in cosmological observations.

  1. Distinctive ultraviolet structure of extra-dimensional Yang-Mills theories by integration of heavy Kaluza-Klein modes

    Science.gov (United States)

    García-Jiménez, I.; Novales-Sánchez, H.; Toscano, J. J.

    2016-05-01

    One-loop Standard Model observables produced by virtual heavy Kaluza-Klein fields play a prominent role in the minimal model of universal extra dimensions. Motivated by this aspect, we integrate out all the Kaluza-Klein heavy modes coming from the Yang-Mills theory set on a spacetime with an arbitrary number, n , of compact extra dimensions. After fixing the gauge with respect to the Kaluza-Klein heavy gauge modes in a covariant manner, we calculate a gauge-independent effective Lagrangian expansion containing multiple Kaluza-Klein sums that entail a bad divergent behavior. We use the Epstein-zeta function to regularize and characterize discrete divergences within such multiple sums, and then we discuss the interplay between the number of extra dimensions and the degree of accuracy of effective Lagrangians to generate or not divergent terms of discrete origin. We find that nonrenormalizable terms with mass dimension k are finite as long as k >4 +n . Multiple Kaluza-Klein sums of nondecoupling logarithmic terms, not treatable by Epstein-zeta regularization, are produced by four-dimensional momentum integration. On the grounds of standard renormalization, we argue that such effects are unobservable.

  2. The distinctive ultraviolet structure of extra-dimensional Yang-Mills theories by integration of heavy Kaluza-Klein modes

    CERN Document Server

    García-Jiménez, I; Toscano, J J

    2016-01-01

    One-loop Standard Model observables produced by virtual heavy Kaluza-Klein fields play a prominent role in the minimal model of universal extra dimensions. Motivated by this aspect, we integrate out all the Kaluza-Klein heavy modes coming from the Yang-Mills theory set on a spacetime with an arbitrary number, $n$, of compact extra dimensions. After fixing the gauge with respect to the Kaluza-Klein heavy gauge modes in a covariant manner, we calculate a gauge independent effective Lagrangian expansion containing multiple Kaluza-Klein sums that entail a bad divergent behavior. We use the Epstein-zeta function to regularize and characterize discrete divergences within such multiple sums, and then we discuss the interplay between the number of extra dimensions and the degree of accuracy of effective Lagrangians to generate or not divergent terms of discrete origin. We find that nonrenormalizable terms with mass dimension $k$ are finite as long as $k>4+n$. Multiple Kaluza-Klein sums of nondecoupling logarithmic te...

  3. Relationship between mind and brain: A proposal of solution based on forms of intra- and extra-individual negentropy

    Directory of Open Access Journals (Sweden)

    Alberto A. Alegre

    2015-03-01

    Full Text Available It is proposed that the problem of the mind-brain relationship can be overcome by a non-classical materialistic model of personality based on the information defined as a special form of negentropy with a structure and activity, which in five intra-individual categories, organizes all and each of the levels of the personality, and, in an extra-individual category organizes the society. This concept of information leads to a monistic view of the universe and turns into conceptions of society, personality, consciousness, and mental activity based on a theoretical framework that explains the nature of the social individual.

  4. Neutrino oscillation provides clues to dark matter and signals from the chilled universe

    CERN Multimedia

    2006-01-01

    The new verification that oscillations exists and neutrinos have mass though not detectible easy provides the first clue to extra dimensions, dark matter, hyperspace and chilled universe acting as a platform below it. (1/2 page)

  5. Vitamin D and extra-skeletal health: causality or consequence.

    Science.gov (United States)

    Al Nozha, Omar M

    2016-07-01

    Vitamin D deficiency /insufficiency is widely recognized as a global health problem that is likely to be involved in pathogenesis or progression of many acute and chronic health disorders. Its relation to skeletal health has been clearly demonstrated and thoroughly examined. This review aims to highlight the continuous debate about the relation between vitamin D and extra-skeletal health and whether it is a causality or just an association. Overall, the available evidence does not meet the criteria for establishing cause-and-effect relationships because of the limitations of observational studies to corroborate the causality due to many potential confounders. Moreover, the causal relationship couldn't be established in randomized studies or in many meta-analyses. This may reflect the fact that vitamin D level reduction is just a biomarker of ill health. The inflammatory processes involved in the disease occurrence and the functional limitations of the diseases would have a role in reducing serum 25-hydroxy vitamin D "25 (OH) D" level, which would explain why low vitamin D is reported in a wide range of disorders. This may underscore the possibility of harm instead of benefit of vitamin D supplementation when its exact role is not fully established, thus many guidelines and interest groups are still hesitant toward recommending replacement in extra-skeletal disease. Future directions entails the need for a large well-designed randomized control trials (RCTs) to resolve the active debate on the benefits of vitamin D replacement for extra-skeletal disease, and not only that, future studies should establish specific, clinically relevant effects of vitamin D repletion, provide cut-values for optimal serum levels of 25 (OH) D, and appropriate doses for non-skeletal health benefits.

  6. Deciphering the molecular basis of multidrug recognition: crystal structures of the Staphylococcus aureus multidrug binding transcription regulator QacR.

    Science.gov (United States)

    Schumacher, Maria A; Brennan, Richard G

    2003-03-01

    Multidrug transporters and their transcriptional regulators are key components of bacterial multidrug resistance (MDR). How these multidrug binding proteins can recognize such chemically disparate compounds represents a fascinating question from a structural standpoint and an important question in future drug development efforts. The Staphylococcus aureus multidrug binding regulator, QacR, is soluble and recognizes an especially wide range of structurally dissimilar compounds, properties making it an ideal model system for deciphering the molecular basis of multidrug recognition. Recent structures of QacR have afforded the first view of any MDR protein bound to multiple drugs, revealing key structural features of multidrug recognition, including a multisite binding pocket.

  7. Extra-amniotic prostaglandin E2 and the unfavourable cervix.

    Science.gov (United States)

    Shepherd, J; Sims, C; Craft, I

    1976-10-02

    A small dose of prostaglandin E2 suspended in a viscous medium was instilled as a single application into the extra-amniotic space of patients with unfavourable induction features the day before planned induction in an attempt to improve the condition of the cervix. Two groups of 15 patients were studied, one receiving prostaglandin E2 250 mug suspended in methyl ethyl cellulose ('Tylose') 6% solution, and the other tylose alone. Cervical status did not change in those receiving tylose alone, whereas a significant improvement occurred in 14 out of 15 patients receiving the prostaglandin. Labour began before formal induction in 1 patient receiving tylose and in 8 receiving prostaglandin.

  8. Extra-Abdominal Desmoid Tumours: A Review of the Literature

    Directory of Open Access Journals (Sweden)

    A. P. Molloy

    2012-01-01

    Full Text Available Extra-abdominal desmoid lesions, otherwise known as aggressive fibromatosis, are slow-growing benign lesions which may be encountered in clinical practice. Recent controversies exist regarding their optimal treatment. Given their benign nature, is major debulking surgery justified, or is it worth administering chemotherapy for a disease process which unusually defies common teaching and responds to such medications? We present a literature review of this particular pathology discussing the aetiology, clinical presentation, and various current controversies in the treatment options.

  9. Scalar dark matter in an extra dimension inspired model

    Science.gov (United States)

    Lineros, Roberto; Pereira dos Santos, Fabio

    2016-05-01

    In this work we consider a singlet scalar propagating in a flat large extra dimension. The first Kaluza-Klein mode associated to this singlet scalar will be a viable dark matter candidate. The tower of new particles enriches the calculation of the relic density due effect of coannihilation. For large mass splitting, the model converges to the predictions of the singlet dark matter model. For nearly degenerate mass spectrum, coannihilations increase the cross-sections used for direct and indirect dark matter searches. We investigate the impact of the Kaluza-Klein tower associated to singlet scalar for indirect and direct detection of dark matter.

  10. Inert scalar dark matter in an extra dimension inspired model

    Energy Technology Data Exchange (ETDEWEB)

    Lineros, R.A.; Santos, F.A. Pereira dos, E-mail: rlineros@ific.uv.es, E-mail: fabio.alex@fis.puc-rio.br [Instituto de Física Corpuscular – CSIC/U. Valencia, Parc Científic, calle Catedrático José Beltrán 2, E-46980 Paterna (Spain)

    2014-10-01

    In this paper we analyze a dark matter model inspired by theories with extra dimensions. The dark matter candidate corresponds to the first Kaluza–Klein mode of an real scalar added to the Standard Model. The tower of new particles enriches the calculation of the relic abundance. For large mass splitting, the model converges to the predictions of the inert singlet dark matter model. For nearly degenerate mass spectrum, coannihilations increase the cross-sections used for direct and indirect dark matter searches. Moreover, the Kaluza–Klein zero mode can mix with the SM higgs and further constraints can be applied.

  11. Noncommutativity, Extra Dimensions, and Power Law Running in the Infrared

    OpenAIRE

    Abel, Steven A.; Jaeckel, Joerg; Khoze, Valentin V.; Ringwald, Andreas

    2005-01-01

    We investigate the running gauge couplings of U(N) noncommutative gauge theories with compact extra dimensions. Power law running of the trace-U(1) gauge coupling in the ultraviolet is communicated to the infrared by ultraviolet/infrared mixing, whereas the SU(N) factors run exactly as in the commutative theory. This results in theories where the experimentally excluded trace-U(1) factors decouple with a power law running of the momentum in the extreme infrared, effectively hiding them from d...

  12. Effective description of brane terms in extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    del Aguila, Francisco; /CAFPE, Granada; Perez-Victoria, Manuel; /CERN; Santiago, Jose; /Fermilab

    2006-01-01

    We study how theories defined in (extra-dimensional) spaces with localized defects can be described perturbatively by effective field theories in which the width of the defects vanishes. These effective theories must incorporate a ''classical'' renormalization, and we propose a renormalization prescription a la dimensional regularization for codimension 1, which can be easily used in phenomenological applications. As a check of the validity of this setting, we compare some general predictions of the renormalized effective theory with those obtained in a particular ultraviolet completion based on deconstruction.

  13. Extra-articular Synovial Chondromatosis Eroding and Penetrating the Acromion

    Science.gov (United States)

    El Rassi, George; Matta, Jihad; Hijjawi, Ayman; Khair, Ousama Abou; Fahs, Sara

    2015-01-01

    Synovial chondromatosis of the shoulder is an uncommon disorder. It usually affects the glenohumeral joint and is characterized by metaplasia of the synovium leading to the formation of osteochondral loose bodies. Few cases of extra-articular subacromial synovial chondromatosis involving the rotator cuff tendon have been reported in the literature. The treatment of previously reported cases consisted of open bursectomy and removal of loose bodies. We report a case of subacromial synovial chondromatosis without rotator cuff involvement but with severe erosion and fracture of the acromion. Treatment consisted of shoulder arthroscopy to remove all loose bodies, total bursectomy, and debridement of the acromion. Potential benefits of arthroscopy were also evaluated. PMID:26697302

  14. Optical investigation of intra- and extra-cellular dynamics

    DEFF Research Database (Denmark)

    Leijnse, Natascha

    In this thesis we investigated intra- and extra-cellular dynamics with the help of optical tweezers and confocal imaging. Firstly, we measured in vivo diffusion inside endothelial cells by tracking lipid granules and compared the results to in vitro diffusion of polystyrene beads in wormlike...... micelles. Furthermore, we studied F-actin dynamics in, and curvature sensing of, a receptor and its ligand on artificially pulled membrane tethers. Force measurements between a cell and an approaching optically trapped bead were conducted in order to probe the endothelial cell's glycocalyx. Finally...

  15. Optical investigation of intra- and extra-cellular dynamics

    DEFF Research Database (Denmark)

    Leijnse, Natascha

    In this thesis we investigated intra- and extra-cellular dynamics with the help of optical tweezers and confocal imaging. Firstly, we measured in vivo diffusion inside endothelial cells by tracking lipid granules and compared the results to in vitro diffusion of polystyrene beads in wormlike...... micelles. Furthermore, we studied F-actin dynamics in, and curvature sensing of, a receptor and its ligand on artificially pulled membrane tethers. Force measurements between a cell and an approaching optically trapped bead were conducted in order to probe the endothelial cell's glycocalyx. Finally...

  16. Primary extra-cranial meningioma following total hip replacement

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, T.J.; Beggs, I. [Royal Infirmary, Department of Radiology, Edinburgh (United Kingdom); Patton, J.T.; Porter, D. [Royal Infirmary, Department of Orthopaedics, Edinburgh (United Kingdom); Salter, D.M.; Al-Nafussi, A. [Royal Infirmary, Department of Pathology, Edinburgh (United Kingdom)

    2009-01-15

    A 61-year-old man presented with pain at the left hip and decreased mobility 10 years after total hip replacement. Imaging demonstrated a large destructive expansile mass adjacent to the prosthesis. Histological analysis confirmed the presence of an extra-cranial meningioma. Primary tumours after total hip replacement are rare and include soft tissue sarcomas, bone sarcomas and lymphomas. To our knowledge, no previous cases of primary extracranial meningioma have been identified. The imaging features, histology, pathogenesis and differential diagnosis are discussed. (orig.)

  17. Extra phase noise from thermal fluctuations in nonlinear optical crystals

    DEFF Research Database (Denmark)

    César, J. E. S.; Coelho, A.S.; Cassemiro, K.N.

    2009-01-01

    We show theoretically and experimentally that scattered light by thermal phonons inside a second-order nonlinear crystal is the source of additional phase noise observed in optical parametric oscillators. This additional phase noise reduces the quantum correlations and has hitherto hindered the d...... the direct production of multipartite entanglement in a single nonlinear optical system. We cooled the nonlinear crystal and observed a reduction in the extra noise. Our treatment of this noise can be successfully applied to different systems in the literature....

  18. Deciphering the geochemical and mineralogical changes of a Miocene sedimentary basin infill, Mendoza Province, Argentina

    Science.gov (United States)

    Hunger, Gabriel; Moscariello, Andrea; Ventra, Dario

    2017-04-01

    Sediments deposited in foreland basins are accurate recorders of processes acting at different temporal and spatial scales during orogenic uplift. The effects of allogenic forcing on foreland sedimentation are well known at basin-scale, but uncertainties remain in deciphering and interpreting them at higher resolution, and in differentiating them from the sedimentary changes due to autogenic processes. We present observations on the continental sedimentology and stratigraphy of the Central Argentinian Foreland. The majority of the basin infill is comprised by the Mariño Fm. and La Pilona Fm., which were deposited during the Miocene and cover almost 2000 m of stratigraphy. The large scale stratigraphy trend leads to interpret the entire alluvial system as a large fluvial fan that prograded over the proximal margin of the foreland basin. The basin infill records a continuous sediment supply from the rising Principal Cordillera and the first stages of the uplift of the Frontal Cordillera. The interaction of different allogenic forcing factors, but also autogenic processes, is recorded in the compositional changes of the sedimentary infill. This project aims to provide a detailed reconstruction of paleoenvironmental dynamics and unravel the relative roles of climate and tectonics, using a high-resolution, integrated compositional and sedimentological analysis of the Mariño Formation and the basal part of the La Pilona Formation. The followed approach embodies the use of automated QEMSCAN technology, geochemistry, heavy-minerals and radiogenic isotope analysis. Along 1500 m of stratigraphy we recognize compositional variations related to the evolution of the basin infill due to, at least, 5 phases of non-steady state conditions. Principal component analysis done with the major elements, main mineral phases and heavy minerals allow us to recognize the importance of the weathering and diagenesis in the total compositional variability. The A-CN-K ternary diagram displays

  19. Deciphering the transcriptional circuitry of microRNA genes expressed during human monocytic differentiation

    KAUST Repository

    Schmeier, Sebastian

    2009-12-10

    Background: Macrophages are immune cells involved in various biological processes including host defence, homeostasis, differentiation, and organogenesis. Disruption of macrophage biology has been linked to increased pathogen infection, inflammation and malignant diseases. Differential gene expression observed in monocytic differentiation is primarily regulated by interacting transcription factors (TFs). Current research suggests that microRNAs (miRNAs) degrade and repress translation of mRNA, but also may target genes involved in differentiation. We focus on getting insights into the transcriptional circuitry regulating miRNA genes expressed during monocytic differentiation. Results: We computationally analysed the transcriptional circuitry of miRNA genes during monocytic differentiation using in vitro time-course expression data for TFs and miRNAs. A set of TF?miRNA associations was derived from predicted TF binding sites in promoter regions of miRNA genes. Time-lagged expression correlation analysis was utilised to evaluate the TF?miRNA associations. Our analysis identified 12 TFs that potentially play a central role in regulating miRNAs throughout the differentiation process. Six of these 12 TFs (ATF2, E2F3, HOXA4, NFE2L1, SP3, and YY1) have not previously been described to be important for monocytic differentiation. The remaining six TFs are CEBPB, CREB1, ELK1, NFE2L2, RUNX1, and USF2. For several miRNAs (miR-21, miR-155, miR-424, and miR-17-92), we show how their inferred transcriptional regulation impacts monocytic differentiation. Conclusions: The study demonstrates that miRNAs and their transcriptional regulatory control are integral molecular mechanisms during differentiation. Furthermore, it is the first study to decipher on a large-scale, how miRNAs are controlled by TFs during human monocytic differentiation. Subsequently, we have identified 12 candidate key controllers of miRNAs during this differentiation process. 2009 Schmeier et al; licensee Bio

  20. Next generation haplotyping to decipher nuclear genomic interspecific admixture in Citrus species: analysis of chromosome 2.

    Science.gov (United States)

    Curk, Franck; Ancillo, Gema; Garcia-Lor, Andres; Luro, François; Perrier, Xavier; Jacquemoud-Collet, Jean-Pierre; Navarro, Luis; Ollitrault, Patrick

    2014-12-29

    The most economically important Citrus species originated by natural interspecific hybridization between four ancestral taxa (Citrus reticulata, Citrus maxima, Citrus medica, and Citrus micrantha) and from limited subsequent interspecific recombination as a result of apomixis and vegetative propagation. Such reticulate evolution coupled with vegetative propagation results in mosaic genomes with large chromosome fragments from the basic taxa in frequent interspecific heterozygosity. Modern breeding of these species is hampered by their complex heterozygous genomic structures that determine species phenotype and are broken by sexual hybridisation. Nevertheless, a large amount of diversity is present in the citrus gene pool, and breeding to allow inclusion of desirable traits is of paramount importance. However, the efficient mobilization of citrus biodiversity in innovative breeding schemes requires previous understanding of Citrus origins and genomic structures. Haplotyping of multiple gene fragments along the whole genome is a powerful approach to reveal the admixture genomic structure of current species and to resolve the evolutionary history of the gene pools. In this study, the efficiency of parallel sequencing with 454 methodology to decipher the hybrid structure of modern citrus species was assessed by analysis of 16 gene fragments on chromosome 2. 454 amplicon libraries were established using the Fluidigm array system for 48 genotypes and 16 gene fragments from chromosome 2. Haplotypes were established from the reads of each accession and phylogenetic analyses were performed using the haplotypic data for each gene fragment. The length of 454 reads and the level of differentiation between the ancestral taxa of modern citrus allowed efficient haplotype phylogenetic assignations for 12 of the 16 gene fragments. The analysis of the mixed genomic structure of modern species and cultivars (i) revealed C. maxima introgressions in modern mandarins, (ii) was

  1. Progress and challenges in deciphering the glacial chronology of the Alpine Lateglacial of the Eastern Alps

    Science.gov (United States)

    Reitner, Juergen

    2015-04-01

    For more than a hundred years efforts have been undertaken to decipher the Alpine Lateglacial (appr. 20 -12 ka), i.e., the period beginning with the withdrawal of the LGM glaciers from their tongue basins until the onset of the Holocene. Since the pioneering work of Penck & Brückner many modifications and improvements of the original subdivision into glacial stadials have been put forward. Especially the application of equilibrium line altitude depressions (ΔELAs) resulted in the definition of new glacial stadials since the 1960's. In addition, previously defined stadials were re-defined using morphological criteria as well as ΔELAs but without any reference to the original type localities. Finally, modern geochronology, especially surface exposure dating with cosmogenic nuclides, helped to establish a chronological framework and enabled correlation with high-resolution marine and ice-core records and elaborated paleoclimatic consideration. However, the results of comprehensive geological mapping in combination with surface exposure dating and radiocarbon dating indicate a bias in the commonly used subdivision of the Alpine Lateglacial. This seems to be, on the one hand, the result of a rigorous application of differences in ΔELA for chronological correlations, which led to the underestimation of regional differences within one climatic phase. On the other hand, only one type-locality has been dated so far. Moreover, as no "type-valley" exists where all moraines of the proposed glacial stadials are evident, we run into the danger of using a sub-division of the Alpine Lateglacial, which contains unjustified chronostratigraphic artefacts. In other words, based on recent work an overclassification may have been established. Beyond the well-known Younger Dryas glaciation only a floating or at least poorly referenced stratigraphy prior to the Bølling/Allerød interstadial (> 14.7 ka) is in use. Examples will be presented which show the current problems and how

  2. Europa frente a lo extraño

    Directory of Open Access Journals (Sweden)

    Bernhard Waldenfels

    2012-02-01

    modo conciso y resumido, pero recogida luego en su versión definitiva en el capítulo 6 de su libro Topographie des Fremden, volumen primero de los cuatro de que se compone su magna obra Studien zur Phanomenologie des Fremden, publicada por la editorial Suhrkamp de Frankfurt del Meno en 1997. Queremos agradecer al autor y a la editorial su cortesía al permitir que publiquemos la traducción castellana de ese ensayo. "Thinking Europe at its limits", as proposed in 1992 by a group of philosophers from the University of Strasbourg -Denis Guénoun, Philippe Lacoue-Labarthe, Jean-Luc Nancy, Daniel Payot-, means considering what the "geo-philosophy of Europe" is as an essential question that encompasses all truthful reflection surrounding the idea of Europe. The debate, to which a diverse group of colleagues and friends from different nations were invited, advanced the very possibility of an identification of Europe, together with the profoundness, in other words the very violence that this possibility (or impossibility implies, as confirmed time and again since then by recent and highly topical events. The proposal was everything but futile. Indeed, as is well known and was confirmed by the group itself some months later in July 1993, what is certain is that a storm of  terrible furores broke out and atrocious upheavals were expressed,  both intra- and extra-European, that, if nothing else, urge us to consider whether the project of what deserves to be known as a "world"may or may not be confused with the exclusive exportation of what Europe has invented, produced and identified. The future appears to be in the grip of two morbid figures, two symmetrical nightmares: the myth of a homogeneous planet, like a gigantic Europe spreading everywhere; and a confined Europe, imprisoned in its imprecise and uncertain boundaries, a kind of isolating barricade or trenches enabling it to reclusively consume the illusion of its supposed welfare. This deplorable alternative incites

  3. Properties of extra-planar H I clouds in the outer part of the Milky Way

    Science.gov (United States)

    Dedes, L.; Kalberla, P. W. M.

    2010-01-01

    Context. There is mounting evidence for an extra-planar gas layer around the Milky Way disk, similar to the anomalous H I gas detected in a few other galaxies. As much as 10% of the gas may be in this phase. Aims: We analyze H I clouds located in the disk-halo interface outside the solar circle to probe the properties of the extra-planar H I gas, which is following Galactic rotation. Methods: We use the Leiden/Argentine/Bonn (LAB) 21-cm line survey to search for H I clouds which take part in the rotation of the Galactic plane, but are located above the disk layer. Selected regions are mapped with the Effelsberg 100-m telescope. Two of the H I halo clouds are studied in detail for their small scale structure using the Westerbork Synthesis Radio Telescope (WSRT)[The Westerbork Synthesis Radio Telescope is operated by ASTRON (Netherlands Foundation for Research in Astronomy) with support from the Netherlands Foundation for Scientific Research NWO.] and the NRAO Very Large Array (VLA)[The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.]. Results: Data from the 100 m telescope allow for the parameterization of 25 distinct H I halo clouds at Galactocentric radii 10 kpc 1.3 cm-3, masses up to 24 M⊙, and are on average in pressure equilibrium with the surrounding envelopes. Pressures and densities fall within the expectations from theoretical phase diagrams (P vs. ). The H I cores tend to be unstable if one assumes a thermally bistable medium, but are in better agreement with models that predict thermal fragmentation driven by a turbulent flow.

  4. Probing extra dimension through gravitational wave observations of compact binaries and their electromagnetic counterparts

    CERN Document Server

    Yu, Hao; Huang, Fa Peng; Wang, Yong-Qiang; Meng, Xin-He; Liu, Yu-Xiao

    2016-01-01

    The gravitational wave (GW) observations of compact binaries and their possible electromagnetic counterparts may be used to probe the nature of the extra dimension. It is widely accepted that gravitons and photons are the only two completely confirmed objects that can travel along the null geodesics in our four-dimensional space-time. But when one considers that there exists the fifth dimension and only the GW can propagate freely in the bulk, the causal propagations of the GW and electromagnetic wave (EMW) are in general different. In this paper, we compute the null geodesics of the GW and EMW in a five-dimensional anti-de Sitter space-time and our four-dimensional universe in the present of the curvature of universe $k$, respectively. We show that for general cases the horizon radius of the GW is longer than the EMW within the equal time. Taking the GW 150914 event detected by the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) and the X-ray event detected by the Fermi Gamma-ray Burst Mo...

  5. Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy

    Directory of Open Access Journals (Sweden)

    H. Thomas Temple

    2011-08-01

    Full Text Available Fibromatosis, or extra-abdominal desmoid tumor, is a benign disease which often has an aggressive clinical course that can be difficult to treat. We performed a retrospective review of 16 patients (12 females and four males with a mean age of 34.2 years treated with methotrexate and vinblastine for newly diagnosed or recurrent extra-abdominal desmoid tumor. The mean age of our patient cohort was 34.2 years (range 11–70, and the mean tumor size was 11.5 cm (range 2.5–21.2 cm. The mean duration of therapy was 12 months with an average follow-up of 43 months (range 1–149 months. Fourteen of 16 patients demonstrated a clinical response to treatment. Eight of 14 patients demonstrated a radiologic decrease in tumor size. Only one patient progressed on therapy. Six patients developed recurrent symptoms after discontinuation of treatment. Chemotherapy-related symptoms including neutropenia, nausea, and vomiting were common and observed in most patients, however these side effects were mild and transient. Five patients developed peripheral neuropathy that prompted a change from vinblastine to vinorelbine during treatment. One potentially life-threatening complication (pneumocystis pneumonia occurred which was diagnosed early and successfully treated. The use of methotrexate and vinblastine/vinorelbine in the management of fibromatosis appears to be an effective treatment with minimal treatment-related side effects.

  6. Extra-large letter spacing improves reading in dyslexia.

    Science.gov (United States)

    Zorzi, Marco; Barbiero, Chiara; Facoetti, Andrea; Lonciari, Isabella; Carrozzi, Marco; Montico, Marcella; Bravar, Laura; George, Florence; Pech-Georgel, Catherine; Ziegler, Johannes C

    2012-07-10

    Although the causes of dyslexia are still debated, all researchers agree that the main challenge is to find ways that allow a child with dyslexia to read more words in less time, because reading more is undisputedly the most efficient intervention for dyslexia. Sophisticated training programs exist, but they typically target the component skills of reading, such as phonological awareness. After the component skills have improved, the main challenge remains (that is, reading deficits must be treated by reading more--a vicious circle for a dyslexic child). Here, we show that a simple manipulation of letter spacing substantially improved text reading performance on the fly (without any training) in a large, unselected sample of Italian and French dyslexic children. Extra-large letter spacing helps reading, because dyslexics are abnormally affected by crowding, a perceptual phenomenon with detrimental effects on letter recognition that is modulated by the spacing between letters. Extra-large letter spacing may help to break the vicious circle by rendering the reading material more easily accessible.

  7. Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, Corey [Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72211 (United States); Emory, Cynthia [Wake Forest School of Medicine, Medical Center Blvds, Winston-Salem, NC 27157 (United States); Adams, Sheila [Department of Orthopaedics and Rehabilitation, University of Miami Miller School of Medicine, Cedars Medical Center, 1400 NW 12th Avenue (R-12), Miami, FL 33136 (United States); Cohen, Jonathan [Division of Psychology, University of Miami Miller School of Medicine, 1695 N.W. 9th Ave. (D-29), Miami, FL 33136 (United States); Pitcher, John David [Department of Orthopaedics and Rehabilitation, University of Miami School of Medicine, 1400 NW 12th Avenue (R-12), Miami, FL 33136 (United States); Potter, Benjamin Kyle [Department of Orthopaedic Surgery, Walter Reed Army Medical Center, 6900 Georgia Avenue North West, Washington, D.C., 20307 (United States); Temple, H. Thomas [Department of Orthopaedic Surgery, University of Miami Miller School of Medicine, 1600 N.W. 10th Avenue (R-12), Miami, FL 33136 (United States)

    2011-08-25

    Fibromatosis, or extra-abdominal desmoid tumor, is a benign disease which often has an aggressive clinical course that can be difficult to treat. We performed a retrospective review of 16 patients (12 females and four males) with a mean age of 34.2 years treated with methotrexate and vinblastine for newly diagnosed or recurrent extra-abdominal desmoid tumor. The mean age of our patient cohort was 34.2 years (range 11–70), and the mean tumor size was 11.5 cm (range 2.5–21.2 cm). The mean duration of therapy was 12 months with an average follow-up of 43 months (range 1–149 months). Fourteen of 16 patients demonstrated a clinical response to treatment. Eight of 14 patients demonstrated a radiologic decrease in tumor size. Only one patient progressed on therapy. Six patients developed recurrent symptoms after discontinuation of treatment. Chemotherapy-related symptoms including neutropenia, nausea, and vomiting were common and observed in most patients, however these side effects were mild and transient. Five patients developed peripheral neuropathy that prompted a change from vinblastine to vinorelbine during treatment. One potentially life-threatening complication (pneumocystis pneumonia) occurred which was diagnosed early and successfully treated. The use of methotrexate and vinblastine/vinorelbine in the management of fibromatosis appears to be an effective treatment with minimal treatment-related side effects.

  8. Experimental investigation of micro heat pipe with extra fluid

    Science.gov (United States)

    Mihai, Ioan; Sprinceana, Siviu

    2016-12-01

    The thermal micro pipes which were aimed to the cooling of the electrical systems, were realized until the present day in different constructive ways. If the first thermal pipes had had at the base the thermo-siphon system [1], afterwards it had been developed the thermal micro pipes [2], thanks to their increased capacity of heat dissipation of the surfaces covered by big densities of the thermal flow. The article, presents in the first part, the physical characteristics of the elements which embody a thermal micro pipe and which generates an excess of liquid. For this it has been realized an experimental setup. Measurements were taken by aid of a laser profilometer of the coverage material in two cases. The first one considered the material without being soaked in the liquid, and for the second one, the measurements were taken when the material was supersaturated with liquid. Since the setup allows for temperature monitoring, determinations were effectuated in the vaporization, adiabatic and condensation areas. The temperature field was determined along a thermal micro pipe in the case of extra fluid. The experimental determinations allowed verifying if the method proposed by Mihai and Olariu [3], for cooling of the electronic components, through a semi active method with the share of extra fluid in the vaporization area of the thermal micro pipe, works. It was studied how the temperature modifies in the vaporization and condensation areas and by the contrast of the theoretical results obtained through the evaluation with the experimental ones.

  9. Inflation with an extra light scalar field after Planck

    CERN Document Server

    Vennin, Vincent; Wands, David

    2015-01-01

    Bayesian inference techniques are used to investigate situations where an additional light scalar field is present during inflation and reheating. This includes (but is not limited to) curvaton-type models. We design a numerical pipeline where $\\simeq 200$ inflaton setups $\\times\\, 10$ reheating scenarios $= 2000$ models are implemented and we present the results for a few prototypical potentials. We find that single-field models are remarkably robust under the introduction of light scalar degrees of freedom. Models that are ruled out at the single-field level are not improved in general, because good values of the spectral index and the tensor-to-scalar ratio can only be obtained for very fine-tuned values of the extra field parameters and/or when large non-Gaussianities are produced. The only exception is quartic large-field inflation, so that the best models after Planck are of two kinds: plateau potentials, regardless of whether an extra field is added or not, and quartic large-field inflation with an ext...

  10. Standard Model with extra dimensions and its zeta function regularization

    CERN Document Server

    García-Jiménez, I; Martínez-Pascual, E; Nápoles-Cañedo, G I; Novales-Sánchez, H; Toscano, J J

    2016-01-01

    We start from a field theory governed by the extra-dimensional $ISO(1,3+n)$ Poincar\\'e group and by the extended SM gauge group, $G({\\cal M}^{4+n})$. Then we construct an effective field theory whose symmetry groups are $ISO(1,3)$ and $G({\\cal M}^{4})$. The transition is carried out via two canonical transformations: a map that preserves, but it hides, the $SO(1,3+n)$ symmetry; and a transformation, given by Fourier series, that explicitly breaks $ISO(1,3+n)$ into $ISO(1,3)$, but conserves and hides the gauge symmetry $G({\\cal M}^{4+n})$, which manifests through nonstandard gauge transformations. From the 4-dimensional perspective, a particle that propagates in compact extra dimensions unfolds into a family of fields that reduces to the SM field if the size of the compact manifold is negligible. We include a full catalogue of Lagrangian terms that can be used to derive Feynman rules. The divergent character of the theory at one-loop is studied. A regularization scheme, based on the Epstein zeta function (EZF)...

  11. Auto-Concealment of Supersymmetry in Extra Dimensions

    CERN Document Server

    Dimopoulos, Savas; March-Russell, John; Scoville, James

    2014-01-01

    In supersymmetric (SUSY) theories with extra dimensions the visible energy in sparticle decays can be significantly reduced and its energy distribution broadened, thus significantly weakening the present collider limits on SUSY. The mechanism applies when the lightest supersymmetric particle (LSP) is a bulk state-- e.g. a bulk modulino, axino, or gravitino-- the size of the extra dimensions larger than ~$10^{-14}$ cm, and for a broad variety of visible sparticle spectra. In such cases the lightest ordinary supersymmetric particle (LOSP), necessarily a brane-localised state, decays to the Kaluza-Klein (KK) discretuum of the LSP. This dynamically realises the compression mechanism for hiding SUSY as decays into the more numerous heavier KK LSP states are favored. We find LHC limits on right-handed slepton LOSPs evaporate, while LHC limits on stop LOSPs weaken to ~350-410 GeV compared to ~700 GeV for a stop decaying to a massless LSP. Similarly, for the searches we consider, present limits on direct production o...

  12. Uber-naturalness: unexpectedly light scalars from supersymmetric extra dimensions

    CERN Document Server

    Burgess, C P; Quevedo, F

    2010-01-01

    Standard lore asserts that quantum effects generically forbid the occurrence of light (non-pseudo-Goldstone) scalars having masses smaller than the Kaluza Klein scale, M_KK, in extra-dimensional models, or the gravitino mass, M_3/2, in supersymmetric situations. We argue that a hidden assumption underlies this lore: that the scale of gravitational physics, M_g, (e.g. the string scale, M_s, in string theory) is of order the Planck mass, M_p = 10^18 GeV. We explore sensitivity to this assumption using the spectrum of masses arising within the specific framework of large-volume string compactifications, for which the ultraviolet completion at the gravity scale is explicitly known to be a Type IIB string theory. In such models the separation between M_g and M_p is parameterized by the (large) size of the extra dimensional volume, V (in string units), according to M_p: M_g: M_KK: M_3/2 = 1: V^{-1/2}: V^{-2/3}: V^{-1}. We find that the generic size of quantum corrections to masses is of the order of M_KK M_3/2 / M_...

  13. Proton lifetime from SU(5) unification in extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Alciati, Maria Laura; Feruglio, Ferruccio E-mail: ferruccio.feruglio@pd.infn.it; Lin Yin; Varagnolo, Alvise

    2005-03-01

    We provide detailed estimates of the proton lifetime in the context of simple supersymmetric SU(5) grand unified models with an extra compact spatial dimension, described by the orbifold S/(Z{sub 2} x Z{sub 2}') and by a large compactification scale Mc. We focus on a class of models where the grand unified symmetry is broken by the compactification mechanism and where baryon violation proceeds mainly through gauge vector boson exchange so that the proton lifetime scales as the fourth power of Mc. We carefully compute Mc from a next-to-leading analysis of gauge coupling unification and we find that Mc can only be predicted up to an overall factor one hundred. The simplest model, where the dominant decay mode is ({pi}{sup 0}e+) and has no flavour suppression, is strongly constrained by existing data, but not totally ruled out. We also analyze models where some of the matter fields are localized in the extra space and proton decay is flavour suppressed. In models associated to anarchy in the neutrino sector the preferred decay channel is (K+{l_brace}{nu}-bar{r_brace}) and the lifetime can be within the reach of the next generation of experiments. (author)

  14. Constraining extra-fermion(s) from the Higgs boson data

    CERN Document Server

    Moreau, G

    2012-01-01

    First, we study the fit of the Higgs boson rates, based on all the latest collider data, in the effective framework for any Extra-Fermion(s) [EF]. The best-fit results are presented in a generic formalism allowing to apply those for the test of any EF scenario. The variations of the fit with each one of the five fundamental parameters are described, and, the obtained fits can be better than in the Standard Model (SM). We show how the determination of the EF loop-contributions to the Higgs couplings with photons and gluons is relying on the knowledge of the top and bottom Yukawa couplings (affected by EF mixings); for determining the latter coupling, the relevance of the investigation of the Higgs production in association with bottom quarks is emphasized. In the instructive approximation of a single EF, we find that the constraints from the fit already turn out to be quite predictive, in both cases of an EF mixed or not with SM fermions, and especially when combined with the extra-quark (-lepton) mass bounds ...

  15. Brane worlds theories with one or two extra dimensions

    CERN Document Server

    Salvio, Alberto

    2013-01-01

    This book is roughly divided in three parts. The first one is a general introduction to theories with extra dimensions and, more specifically, to brane worlds. Both old-fashioned topics (such as Kaluza-Klein theories) and more modern aspects (e.g. Large Extra Dimensions and Randall-Sundrum models) are discussed. The second and third parts (which we refer to as Part I and II respectively) are essentially two monographs. There, the reader is guided through the construction of the 4D effective field theory derived from higher dimensional (in particular five-dimensional and six-dimensional) models. Part I is devoted to the study of how the heavy Kaluza-Klein modes contribute to the low energy dynamics of the light modes. Part II concerns instead the analysis of the spectrum arising from non-standard compactifications of six-dimensional (supersymmetric) theories, involving a warp factor and conical defects in the internal manifold. Several applications of the above mentioned topics are discussed, providing an up t...

  16. Deformed extra space and the smallness of the cosmological constant

    CERN Document Server

    Rubin, Sergey G

    2016-01-01

    The mechanism of different universes formation is elaborated. Each universe is characterized by a unique cosmological constant. It is shown that the set of cosmological constants has the cardinality of the continuum and contains zero cosmological constant. Those universes with cosmological constants near zero could be filled by complex structures. There is no necessity in a special mechanism of the fine tuning. The role of quantum fluctuations is studied.

  17. Universal Usability

    Science.gov (United States)

    Horton, Sarah; Leventhal, Laura

    Universal usability of World Wide Web (Web) environments—that is, having 90% of households as successful users—requires universal access, usability, and universal design. Factors such as Web technology and user-centered design contribute to universal access and usability, but key to universal usability is a universal design methodology. Universal design principles for the Web follow from universal design principles for the built environment, and emphasize perceptibility, self-explanation, and tailorability for the user. Universally usable Web environments offer the benefit of expanded participation, as well as the unanticipated benefits that generally follow from innovative design initiatives. However, to achieve Web universal usability, Web designers need tools that facilitate the design of intuitive interfaces without sacrificing universal access.

  18. Lipase production by yeasts from extra virgin olive oil.

    Science.gov (United States)

    Ciafardini, G; Zullo, B A; Iride, A

    2006-02-01

    Newly produced olive oil has an opalescent appearance due to the presence of solid particles and micro-drops of vegetation water from the fruits. Some of our recent microbiological research has shown that a rich micro-flora is present in the suspended fraction of the freshly produced olive oil capable of improving the quality of the oil through the hydrolysis of the oleuropein. Present research however has, for the first time, demonstrated the presence of lipase-positive yeasts in some samples of extra virgin olive oil which can lower the quality of the oil through the hydrolysis of the triglycerides. The tests performed with yeasts of our collection, previously isolated from olive oil, demonstrated that two lipase-producing yeast strains named Saccharomyces cerevisiae 1525 and Williopsis californica 1639 were able to hydrolyse different specific synthetic substrates represented by p-nitrophenyl stearate, 4-nitrophenyl palmitate, tripalmitin and triolein as well as olive oil triglycerides. The lipase activity in S. cerevisiae 1525 was confined to the whole cells, whereas in W. californica 1639 it was also detected in the extracellular fraction. The enzyme activity in both yeasts was influenced by the ratio of the aqueous to the organic phase reaching its maximum value in S. cerevisiae 1525 when the water added to the olive oil was present in a ratio of 0.25% (v/v), whereas in W. californica 1639 the optimal ratio was 1% (v/v). Furthermore, the free fatty acids of olive oil proved to be good inducers of lipase activity in both yeasts. The microbiological analysis carried out on commercial extra virgin olive oil, produced in four different geographic areas, demonstrated that the presence of lipase-producing yeast varied from zero to 56% of the total yeasts detected, according to the source of oil samples. The discovery of lipase-positive yeasts in some extra virgin olive oils leads us to believe that yeasts are able to contribute in a positive or negative way towards

  19. Deciphering the record of short-term base-level changes in Gilbert-type deltas

    Science.gov (United States)

    Gobo, Katarina; Ghinassi, Massimiliano; Nemec, Wojciech

    2016-04-01

    The geometrical relationship of fluvial topset to subaqueous foreset in a Gilbert-type delta may be 'sigmoidal' (transitional) or 'oblique' (erosional), which is generally attributed - respectively - to a rise or fall of the delta shoreline's time-distance trajectory and considered to reflect base-level changes. However, since every episode of a base-level fall forces the fluvial distributary system to cut down, the delta-brink sigmoidal signature of a preceding base-level rise tends to be removed. The geometrical record of short-term base-level changes in a Gilbert-type delta thus tends to be obliterated by fluvial erosion. The issue addressed in this presentation is whether the fully-preserved foreset to bottomset deposits may serve as a key for deciphering the base-level history of an ancient Gilbert-type delta. Outcrop studies of Plio-Pleistocene Gilbert-type deltas at the southern margin of the Corinth Rift, Greece, reveal a genetic relationship between the delta-brink morphodynamics controlled by base level behaviour and the processes of subaqueous sediment dispersal on the delta slope and in its foot zone. The component facies are deposits of turbidity currents (whether slope-derived brief surges or longer-duration hyperpycnal flows), cohesionless debrisflows and loose-gravel debrisfalls. The development of sigmoidal delta-brink architecture appears to be accompanied by deposition of a debrite-dominated facies assemblage (DFA) of delta foreset beds, thought to form when the aggrading delta front tends to store sediment and undergoes discrete gravitational collapses. Development of oblique delta-brink architecture is accompanied by deposition of a turbidite-dominated facies assemblage (TFA) of foreset beds, which is thought to form when the delta-front accommodation decreases and the sediment carried by hyperpycnal effluent largely bypasses the front. The alternation of TFA and DFA facies assemblages in delta foreset is thus attributed to changes in delta

  20. Deciphering the combinatorial roles of geometric, mechanical, and adhesion cues in regulation of cell spreading.

    Directory of Open Access Journals (Sweden)

    Greg M Harris

    Full Text Available Significant effort has gone towards parsing out the effects of surrounding microenvironment on macroscopic behavior of stem cells. Many of the microenvironmental cues, however, are intertwined, and thus, further studies are warranted to identify the intricate interplay among the conflicting downstream signaling pathways that ultimately guide a cell response. In this contribution, by patterning adhesive PEG (polyethylene glycol hydrogels using Dip Pen Nanolithography (DPN, we demonstrate that substrate elasticity, subcellular elasticity, ligand density, and topography ultimately define mesenchymal stem cells (MSCs spreading and shape. Physical characteristics are parsed individually with 7 kilopascal (kPa hydrogel islands leading to smaller, spindle shaped cells and 105 kPa hydrogel islands leading to larger, polygonal cell shapes. In a parallel effort, a finite element model was constructed to characterize and confirm experimental findings and aid as a predictive tool in modeling cell microenvironments. Signaling pathway inhibition studies suggested that RhoA is a key regulator of cell response to the cooperative effect of the tunable substrate variables. These results are significant for the engineering of cell-extra cellular matrix interfaces and ultimately decoupling matrix bound cues presented to cells in a tissue microenvironment for regenerative medicine.

  1. Chiral Orbifold Construction Of Field Theories With Extra Dimensions

    CERN Document Server

    Hailu, G

    2003-01-01

    We build higher dimensional field theories which have chiral fermion zero-modes on orbifolds. We show that orbifold boundary conditions and scalar vacuum expectation values interplay to produce chiral fermions localized on fat three branes. We develop a scheme for computing field propagators in higher dimensional theories obeying chiral orbifold boundary conditions. Using this scheme we compute the loop corrections to an effective field theory in five dimensions. We find that the renormalization group running of the higher dimensional bulk theory leads to a running of the four dimensional brane couplings. We generalize an argument to verify that the chiral anomaly that arises in these chiral orbifold theories is entirely confined on and uniformly distributed over the fixed points of the orbifold, independent of the shape of the chiral zero-modes. We construct a setup in which a scalar field with appropriate profile in the extra dimension is used to address the hierarchy problem and also localize both chiral f...

  2. Architectural communication: Intra and extra activity of architecture

    Directory of Open Access Journals (Sweden)

    Stamatović-Vučković Slavica

    2013-01-01

    Full Text Available Apart from a brief overview of architectural communication viewed from the standpoint of theory of information and semiotics, this paper contains two forms of dualistically viewed architectural communication. The duality denotation/connotation (”primary” and ”secondary” architectural communication is one of semiotic postulates taken from Umberto Eco who viewed architectural communication as a semiotic phenomenon. In addition, architectural communication can be viewed as an intra and an extra activity of architecture where the overall activity of the edifice performed through its spatial manifestation may be understood as an act of communication. In that respect, the activity may be perceived as the ”behavior of architecture”, which corresponds to Lefebvre’s production of space.

  3. Supersymmetric Contributions to the Decay of an Extra Z Boson

    CERN Document Server

    Gherghetta, Tony; Kane, G L; Gherghetta, Tony; Kaeding, Thomas A.; Kane, Gordon L.

    1998-01-01

    We analyse in detail the supersymmetric contributions to the decay of an extra Z boson in effective rank 5 models, including the important effect of D-terms on sfermion masses. The inclusion of supersymmetric decay channels will reduce the Z' branching ratio to standard model particles resulting in lower Z' mass limits than those often quoted. In particular, the supersymmetric parameter space motivated by the recent Fermilab $ee\\gamma\\gamma$ event and other suggestive evidence results in a branching fraction B(Z' -> e^+ e^-)\\simeq 2-4%. The expected cross sections and branching ratios could give a few events in the present data and we speculate on the connection to the three e^+e^- events observed at Fermilab with large dielectron invariant mass.

  4. Baseline-dependent neutrino oscillations with extra-dimensional shortcuts

    Energy Technology Data Exchange (ETDEWEB)

    Hollenberg, Sebastian; Micu, Octavian; Paes, Heinrich [Fakultaet fuer Physik, Technische Universitaet Dortmund, D-44221 Dortmund (Germany); Weiler, Thomas J. [Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235 (United States)

    2010-07-01

    In extra-dimensional scenarios oscillations between active and sterile neutrinos can be governed by a new resonance in the oscillation amplitude. This resonance results when cancelation occurs between two phase differences, the usual kinematic one coming from the neutrino mass-squared difference, and a new geometric one coming from the difference in travel times of the sterile neutrino through the bulk relative to the active neutrino confined to the brane. An asymmetrically-warped 4+1 dimensional metric is introduced for the brane-bulk system. In this case it is found that the resonance condition involves both the neutrino energy E and the travel distance L on the brane; to a good approximation the resonance condition is on the product LE. The model is rich in implications, including the possibility of multiple solutions to the resonance condition, with ramifications for existing data sets, e.g., LSND and MiniBooNE.

  5. Extra-large Tribolium confusum: a new autosomal recessive mutant.

    Science.gov (United States)

    Vardell, H H; Brower, J H

    1975-12-01

    A new mutant of Tribolium confusum Jacquelin duVal (Coleoptera: Tenebrionidae), extra-large (designated xl), was isolated in mating competition tests with red-eye (re) and wild-type (+). Crosses showed that it was autosomal recessive gene with subvital effects. The pupal weights averaged 6.1 and 7.3 mg for males and females, respectively, about twice the weights of the ancestral wild-type. The generation time (egg to adult) was approximately 8 to 9 weeks compared with about 4 weeks for the wild-type. This increase resulted from a lengthening of the larval stage since the durations of the egg and pupal stages were within the ranges of the wild-type. Mean longivity of xl males and females was reduced to 8.5 and 6.0 weeks, respectively at 26.7 +/- 1 degree C and 60% RH.

  6. Signals of Warped Extra Dimensions at the LHC

    CERN Document Server

    Osland, P; Tsytrinov, A V; Paver, N

    2010-01-01

    We discuss the signatures of the spin-2 graviton excitations predicted by the Randall-Sundrum model with one warped extra dimension, in dilepton and diphoton production at LHC. By using a specific angular analysis, we assess the ranges in mass and coupling constant where such gravitons can be discriminated against competitor spin-1 and spin-0 objects, that potentially could manifest themselves in these processes with the same mass and rate of events. Depending on the value of the coupling constant to quarks and leptons, the numerical results indicate graviton identification mass ranges up to 1.1-2.4 TeV and 1.6-3.2 TeV for LHC nominal energy of 14 TeV and time-integrated luminosity of 10 and 100~${\\rm fb}^{-1}$, respectively.

  7. Older people's participation in extra-cost disability benefits.

    Science.gov (United States)

    Zantomio, Francesca

    2013-01-01

    The targeting of an UK extra-cost disability benefit for older people, Attendance Allowance, is analyzed using longitudinal data from the British Household Panel Survey. First, a binary model of benefit participation is used to investigate whether receipt is responsive to the onset of disability. Second, matching estimators are used to evaluate the consequences of missed participation on later financial wellbeing. Results indicate that participation is highly responsive to the onset of disability, although the chance of delays in receipt emerges. Personal characteristics unrelated to eligibility also appear to influence benefit receipt, translating into sizeable differences in the amount of cash support received. The comparison of recipients with observationally equivalent non-recipients confirms that timely participation reduces disabled older people's financial strain.

  8. Double beta decay and the extra-dimensional seesaw mechanism

    CERN Document Server

    Bhattacharya, G; Pilaftsis, Apostolos; Päs, H

    2004-01-01

    We study the model-building conditions under which an observable 0vBB decay signal is predicted due to Kaluza-Klein singlet neutrinos in theories with large extra dimensions. Our analysis is based on 5-dimensional singlet-neutrino models compactified on an S^1/Z_2 orbifold, where the Standard-Model fields are localized on a 3-brane. We show that sizeable 0vBB rates within the above minimal 5-dimensional framework would require a non-vanishing shift of the 3-brane from the orbifold fixed points by an amount smaller than the typical scale 100 inverse MeV characterizing the Fermi nuclear momentum. The resulting 5-dimensional models predict a sizeable effective Majorana-neutrino mass that could be several orders of magnitude larger than the light neutrino masses.

  9. On higher dimensional Einstein spacetimes with a warped extra dimension

    CERN Document Server

    Ortaggio, Marcello; Pravdova, Alena

    2010-01-01

    We study higher dimensional Einstein spacetimes that can be mapped conformally on other Einstein spacetimes. These admit a simple warped line element (with one extra dimension) that was originally introduced by Brinkmann and that has subsequently appeared in various contexts to describe, e.g., different braneworld models or warped black strings. After clarifying the relation between the general Brinkmann metric and other more specific coordinate systems, we analyze the algebraic type of the Weyl tensor of the solutions. In particular, we describe the relation between Weyl aligned null directions (WANDs) of the lower dimensional Einstein slices and of the full spacetime, which in some cases can be algebraically more special. Possible spacetime singularities introduced by the warp factor are determined via a study of scalar curvature invariants and of Weyl components measured by geodetic observers. Finally, we illustrate how Brinkmann's metric can be employed to generate new solutions by presenting the metric o...

  10. Higher Curvature Gravity in TeV-Scale Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Rizzo, Thomas G.

    2006-03-31

    We begin a general exploration of the phenomenology of TeV-scale extra-dimensional models with gravitational actions that contain higher curvature terms. In particular, we examine how the classic collider signatures of the models of Arkani-Hamed, Dimopoulos and Dvali (missing energy and new dimension-8 contact interactions) and of Randall and Sundrum (TeV-scale graviton Kaluza-Klein resonances) are altered by these modifications to the usual Einstein-Hilbert action. We find that not only are the detailed signatures for these gravitationally induced processes altered but new contributions are found to arise due to the existence of additional scalar Kaluza-Klein states in the spectrum.

  11. ISLES: Probing Extra Dimensions Using a Superconducting Accelerometer

    Science.gov (United States)

    Paik, Ho Jung; Moody, M. Vol; Prieto-Gortcheva, Violeta A.

    2003-01-01

    In string theories, extra dimensions must be compactified. The possibility that gravity can have large radii of compactification leads to a violation of the inverse square law at submillimeter distances. The objective of ISLES is to perform a null test of Newton s law in space with a resolution of one part in 10(exp 5) or better at 100 microns. The experiment will be cooled to less than or equal to 2 K, which permits superconducting magnetic levitation of the test masses. To minimize Newtonian errors, ISLES employs a near null source, a circular disk of large diameter-to-thickness ratio. Two test masses, also disk-shaped, are suspended on the two sides of the source mass at a nominal distance of 100 microns. The signal is detected by a superconducting differential accelerometer. A ground test apparatus is under construction.

  12. Extra-long Float-zones Induced by Thermocapillary Flows

    Science.gov (United States)

    Chen, Yi-Ju; Steen, Paul H.

    1996-11-01

    A model problem is posed to study the influence of flow on the interfacial stability of a nearly cylindrical liquid bridge for lengths near its circumference (the Plateau-Rayleigh limit). Zero gravity is assumed. The flow is generated by a shear stress imposed on the deformable interface. The symmetry of the imposed stress mimics the thermocapillary effect induced on a float-zone by a ring heater (i.e. a full zone). Numerical solutions, complemented by a bifurcation analysis, show that bridges substantially longer than the Plateau-Rayleigh limit are possible. An interaction of the first two capillary instabilities through the stress-induced pressure gradient is responsible. Time-periodic standing waves are also predicted in certain parameter ranges. Motivation comes from extra-long float-zones observed in MEPHISTO space lab experiments (June 1994).

  13. Scalar mass corrections from compact extra dimensions on the lattice

    CERN Document Server

    Del Debbio, Luigi

    2012-01-01

    We explore the phase diagram of the SU(2) Yang-Mills theory in 5 dimensions by numerical simulations. The lattice system shows a dimensionally-reduced phase where the extra dimension is small compared to the four dimensional correlation length. In the low-energy regime of this phase, the system behaves like a four-dimensional gauge theory coupled to an adjoint scalar field. By tuning the bare parameters of the lattice model, we identify lines of constant physics, and analyse the behaviour of the non-perturbative scalar mass as a function of the compactification and the cut-off scales. The perturbative prediction that the effective theory contains a light particle with a mass that is independent of the cut-off is tested against non-pertubative results.

  14. Bounds on Large Extra Dimensions from the Generalized Uncertainty Principle

    CERN Document Server

    Cavaglia, Marco; Hou, Shaoqi

    2016-01-01

    The Generalized Uncertainty Principle (GUP) implies the existence of a physical minimum length scale $l_m$. In this scenario, black holes must have a radius larger than $l_m$. They are hotter and evaporate faster than in standard Hawking thermodynamics. We study the effects of the GUP on black hole production and decay at the LHC in models with large extra dimensions. Lower bounds on the fundamental Planck scale and the minimum black hole mass at formation are determined from black hole production cross section limits by the CMS Collaboration. The existence of a minimum length generally decreases the lower bounds on the fundamental Planck scale obtained in the absence of a minimum length.

  15. Warped extra dimension and inclined events at Pierre Auger Observatory

    CERN Document Server

    Kisselev, A V

    2016-01-01

    The generalized solution for the warp factor of the Randall-Sundrum metric is presented which is symmetric with respect to both branes and explicitly periodic in extra variable. Given that the curvature of the 5-dimensional space-time is small, the expected rate of neutrino-induced inclined events at the Surface Detector of the Pierre Auger Observatory is calculated. Both the "downward-going" (DG) and "Earth-skimming" (ES) neutrinos are considered. By comparing the expected event rate with the recent Auger data on searching for neutrino candidates, the lower bound on the fundamental gravity scale M_5 is obtained. The ratio of the number of the ES air showers to the number of the DG showers is estimated as a function of M_5.

  16. Flavour-changing neutral currents in models with extra ' boson

    Indian Academy of Sciences (India)

    S Sahoo; L Maharana

    2004-09-01

    New neutral gauge bosons ' are the features of many models addressing the physics beyond the standard model. Together with the existence of new neutral gauge bosons, models based on extended gauge groups (rank > 4) often predict new charged fermions also. A mixing of the known fermions with new states, with exotic weak-isospin assignments (left-handed singlets and right-handed doublets) will induce tree-level flavour-changing neutral interactions mediated by exchange, while if the mixing is only with new states with ordinary weak-isospin assignments, the flavour-changing neutral currents are mainly due to the exchange of the new neutral gauge boson '. We review flavour-changing neutral currents in models with extra ' boson. Then we discuss some flavour-changing processes forbidden in the standard model and new contributions to standard model processes.

  17. Extra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes

    Directory of Open Access Journals (Sweden)

    Armin Robubi

    2014-01-01

    Full Text Available Fructose in excessive amounts exerts negative effects on insulin sensitivity, blood pressure, and liver metabolism. These adverse outcomes were attributed to its disturbances of key metabolic pathways in the liver. Recently, possible consequences of high fructose levels directly on adipocytes in vivo have been considered. We have cultured adipocytes in growth media containing 1 g/L fructose additionally to glucose and monitored the cells fate. Cells developed lipid vesicles much earlier with fructose and showed altered kinetics of the expression of mRNAs involved in lipogenesis and hexose uptake. Adiponectin secretion, too, peaked earlier in fructose containing media than in media with glucose only. From these data it can be speculated that similar effects of fructose containing diets happen in vivo also. Apart from toxic action on liver cells, adipocytes might be stimulated to take up extra fructose and generate new lipid vesicles, further dysregulating energy homeostasis.

  18. The Wide Area VISTA Extra-galactic Survey (WAVES)

    CERN Document Server

    Driver, Simon P; Meyer, Martin; Power, Chris; Robotham, Aaron S G; Baldry, Ivan K; Liske, Jochen; Norberg, Peder

    2015-01-01

    The "Wide Area VISTA Extra-galactic Survey" (WAVES) is a 4MOST Consortium Design Reference Survey which will use the VISTA/4MOST facility to spectroscopically survey ~2million galaxies to $r_{\\rm AB} < 22$ mag. WAVES consists of two interlocking galaxy surveys ("WAVES-Deep" and "WAVES-Wide"), providing the next two steps beyond the highly successful 1M galaxy Sloan Digital Sky Survey and the 250k Galaxy And Mass Assembly survey. WAVES will enable an unprecedented study of the distribution and evolution of mass, energy, and structures extending from 1-kpc dwarf galaxies in the local void to the morphologies of 200-Mpc filaments at $z\\sim1$. A key aim of both surveys will be to compare comprehensive empirical observations of the spatial properties of galaxies, groups, and filaments, against state-of-the-art numerical simulations to distinguish between various Dark Matter models.

  19. El extraño caso de Susana Soca

    Directory of Open Access Journals (Sweden)

    Valentina Litvan

    2010-07-01

    Full Text Available Cuando primero Rubén Darío y más tarde Ángel Rama establecen sus respectivas antologías de raros, no solamente quieren destacar a determinadas figuras, rescatarlas, darles visibilidad, sino que están poniendo en cuestión el modo en que se constituye una tradición. ¿Quién la integra y con qué legitimidad ? Partiendo de estas premisas, me interesa analizar el caso de Susana Soca, una escritora uruguaya que parece entrar en la tradición desde un lugar periférico, extraño y extranjerizante ; u...

  20. Fluid responsiveness is predicted by analysis of extra systoles

    DEFF Research Database (Denmark)

    Vistisen, Simon Tilma

    INTRODUCTION. Fluid responsiveness prediction is an unsettled matter for intensive care patients. Preload variables are not reliable and ventilator settings for the vast majority of patients (if at all ventilated) do not accommodate the criteria for otherwise useful dynamic variables [1] (e.......g. pulse pressure variation). Yet, the idea of a varying preload utilised in dynamic variable monitoring may be useful: The extra systolic post-ectopic beat is associated with increased preload, and I hypothesised that systolic blood pressure (SBP) at the post-ectopic beat could be analysed in relation...... to surrounding sinus beats and that the magnitude of the SBP change (DSBP) could predict fluid responsiveness. OBJECTIVES. To study the hypothesis in post-cardiac surgery patients. METHODS. Patients scheduled for a 500 ml volume expansion were observed. In the time frame, 0-30 min prior to volume expansion, ECG...

  1. Shallow extra mixing in solar twins inferred from Be abundances

    CERN Document Server

    Maia, M Tucci; Castro, M; Asplund, M; Ramírez, I; Monroe, T R; Nascimento, J D do; Yong, D

    2015-01-01

    Lithium and beryllium are destroyed at different temperatures in stellar interiors. As such, their relative abundances offer excellent probes of the nature and extent of mixing processes within and below the convection zone. We determine Be abundances for a sample of eight solar twins for which Li abundances have previously been determined. The analyzed solar twins span a very wide range of age, 0.5-8.2 Gyr, which enables us to study secular evolution of Li and Be depletion. We gathered high-quality UVES/VLT spectra and obtained Be abundances by spectral synthesis of the Be II 313 nm doublet. The derived beryllium abundances exhibit no significant variation with age. The more fragile Li, however, exhibits a monotonically decreasing abundance with increasing age. Therefore, relatively shallow extra mixing below the convection zone is necessary to simultaneously account for the observed Li and Be behavior in the Sun and solar twins.

  2. Symbiote transmission and maintenance of extra-genomic associations.

    Science.gov (United States)

    Fitzpatrick, Benjamin M

    2014-01-01

    Symbiotes can be transmitted from parents to offspring or horizontally from unrelated hosts or the environment. A key question is whether symbiote transmission is similar enough to Mendelian gene transmission to generate and maintain coevolutionary associations between host and symbiote genes. Recent papers come to opposite conclusions, with some suggesting that any horizontal transmission eliminates genetic association. These studies are hard to compare owing to arbitrary differences in modeling approach, parameter values, and assumptions about selection. I show that associations between host and symbiote genes (extra-genomic associations) can be described by the same dynamic model as conventional linkage disequilibria between genes in the same genome. Thus, covariance between host and symbiote genomes depends on population history, geographic structure, selection, and co-transmission rate, just as covariance between genes within a genome. The conclusion that horizontal transmission rapidly erodes extra-genomic associations is equivalent to the conclusion that recombination rapidly erodes associations between genes within a genome. The conclusion is correct in the absence of population structure or selection. However, population structure can maintain spatial associations between host and symbiote traits, and non-additive selection (interspecific epistasis) can generate covariances between host and symbiote genotypes. These results can also be applied to cultural or other non-genetic traits. This work contributes to a growing consensus that genomic, symbiotic, and gene-culture evolution can be analyzed under a common theoretical framework. In terms of coevolutionary potential, symbiotes can be viewed as lying on a continuum between the intimacy of genes and the indifference of casually co-occurring species.

  3. Epidemiology of extra pulmonary tuberculosis in Eastern Sudan

    Institute of Scientific and Technical Information of China (English)

    Taj; Eldin; Mohammedein; Abdallah; Fatah; Elrahman; Mohmmed; Toum; Osman; Habeeb; Bashir; Tajedin; Ibrahim; mansoor; Mona; Mamoun; Yuosif; Mustafa; Awad-Elseed; Elkhawad; Idris; Osman; Okud; Abbashar; Osman; Mohammed; Abdel; Aziem; Abdalla; Ali

    2015-01-01

    Objective: To investigate the epidemiological factors associated with extra pulmonary tuberculosis(EPTB) in Kassala, Eastern Sudan.Methods: Patients infected with TB(pulmonary and extra-pulmonary) documented at the hospital were interviewed with a structured questionnaire used to gather socio-demographic information. The diagnosis of EPTB cases was based on presence of tuberculous granulomas in the histological samples, positive PCR to DNA of mycobacterium tuberculosis, radiological i ndings and l uid analysis suggestive of EPTB and clinical diagnosis with adequate response to anti-tuberculous therapy.Results: A total of 985 patients with TB were enrolled in the study, including 761(77.3%) with PTB and 224(22.7%) with EPTB. The mean age(SD) of patients with PTB and EPTB was 33.2(15.4) and 34.7(14.6) years respectively. The prevalence of EPTB was at(22.7%), with TB lymphadenitis 79(35.3%), marking the frequent form of EPTB followed by peritoneal TB 27(12.05%). While residence and occupation were not associated with EPTB, those with lower level of education(OR = 0.3; coni dence intervals(CI) = 0.2-0.5; P < 0.001), female(OR = 8.7, CI = 4.9-15.1, P < 0.001), non vaccination(OR=70.3, CI = 34.2-144.3, P < 0.001), and non smoker(OR = 0.1; CI = 0.06-0.20; P < 0.001), were associated with high prevalence of EPTB. Conclusions: Around one quarter of patients with TB in this study were more likely to have EPTB. Therefore, ef ective strategic plans regarding diagnostic procedures and control measures are needed to reduce the burden of the disease in Sudan.

  4. Anomalous gauge couplings from composite Higgs and warped extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Fichet, Sylvain [International Institute of Physics, UFRN,Av. Odilon Gomes de Lima, 1722, Capim Macio, 59078-400, Natal-RN (Brazil); Gersdorff, Gero von [ICTP South American Institute for Fundamental Research,Instituto de Fisica Teorica, Sao Paulo State University (Brazil)

    2014-03-24

    We examine trilinear and quartic anomalous gauge couplings (AGCs) generated in composite Higgs models and models with warped extra dimensions. We first revisit the SU(2){sub L}×U(1){sub Y} effective Lagrangian and derive the charged and two-photon neutral AGCs. We derive the general perturbative contributions to the pure field-strength operators from spin 0, (1/2), 1 resonances by means of the heat kernel method. In the composite Higgs framework, we derive the pattern of expected deviations from typical SO(N) embeddings of the light composite top partner. We then study a generic warped extra dimension framework with AdS{sub 5} background, recasting in few parameters the features of models relevant for AGCs. We also present a detailed study of the latest bounds from electroweak and Higgs precision observables, with and without brane kinetic terms. For vanishing brane kinetic terms, we find that the S and T parameters exclude KK gauge modes of the RS custodial [non-custodial] scenario below 7.7 [14.7] TeV, for a brane Higgs and below 6.6 [8.1] TeV for a Pseudo Nambu-Goldstone Higgs, at 95% CL. These constraints can be relaxed in presence of brane kinetic terms. The leading AGCs are probing the KK gravitons and the KK modes of bulk gauge fields in parts of the parameter space. In these scenarios, the future CMS and ATLAS forward proton detectors could be sensitive to the effect of KK gravitons in the multi-TeV mass range.

  5. Welfarism and extra-welfarism: a critical overview

    Directory of Open Access Journals (Sweden)

    Brayan Viegas Seixas

    2017-08-01

    Full Text Available Abstract: Rules and principles for guiding decision-making in the health care sector have been debated for decades. Here, we present a critical appraisal of the two most important paradigms in this respect: welfarism and extra-welfarism. While the former deals with the maximization of the overall sum of individual utilities as its primary outcome, the latter has been focusing on the maximization of the overall health status. We argue that welfarism has three main problems: (1 its central idea of overall sum of individual utilities does not capture societal values decisively relevant in the context of health; (2 the use of the Potential Pareto Improvement brings an unresolvable separation between efficiency and equity; and (3 individual utility may not be a good measure in the health sector, given that individuals might value things that diminish their overall health. In turn, the extra-welfarist approach is criticized regarding four main limitations: (1 the advocated expansion of the evaluative space, moving from utility to health, may have represented in reality a narrowing of it; (2 it operates using non-explicit considerations of equity; (3 it still holds the issue of “inability to desire” of unprivileged people being considered the best judges of weighing the criteria used to building the health measures; and (4 there is controversial empirical evidence about society members’ values that support its assumptions. Overall, both paradigms show significant weaknesses, but the debate has still been within the realm of welfare economics, and even the new approaches to resource allocation in health care systems appear to be unable to escape from these boundaries.

  6. Extra-Articular Manifestations of Rheumatoid Arthritis, Now

    Directory of Open Access Journals (Sweden)

    Paloma Vela

    2014-06-01

    Full Text Available Rheumatoid arthritis (RA is a chronic systemic inflammatory disease, characterised by polyarthritis and extra-articular organ disease, including rheumatoid nodules, ophthalmologic manifestations, cardiopulmonary disease, vasculitis, neuropathy, glomerulonephritis, Felty’s syndrome, and amyloidosis. Extra-articular manifestations of RA (ExRA occur in 17.8–40.9% of RA patients, 1.5–21.5% of them presenting as severe forms and usually associated with increased morbidity and mortality. They can develop at any time during the course of the disease, even in the early stages, and are associated with certain predisposing factors, such as the presence of rheumatoid factor, smoking, and long-standing severe disease. Rheumatoid nodules, the most common ExRA, have been found to be associated with the development of severe features, such as vasculitis, rheumatoid lung disease, pericarditis, and pleuritis, especially in those patients who develop them within 2 years from RA diagnosis. There is no uniformity in the definition of the term ExRA, which limits comparability between different studies. Several recent surveys suggest a lower frequency, probably due to a better control of disease activity. Diagnosis of ExRA is a challenge for clinicians, given its variable and complex presentation, and the lack of specific diagnostic tests; it must be based on clinical recognition and exclusion of other causes of the signs and symptoms. Furthermore, management continues to be difficult with a bad prognosis in many conditions. This article reviews the clinical aspects of major ExRA, focusing on incidence, clinical features, and therapeutic approaches, and how modern immunosuppressive therapy can change the outcome.

  7. Radiotherapy studies and extra-nodal non-Hodgkin lymphomas, progress and challenges

    DEFF Research Database (Denmark)

    Specht, L

    2012-01-01

    for the more common extra-nodal organs, e.g. stomach, Waldeyer's ring, skin and brain, are fairly well known and show significant variation. A few randomised trials have been carried out testing the role of radiotherapy in these lymphomas. However, for most extra-nodal lymphomas, randomised trials have...... coverage of extra-nodal lymphomatous involvement with better sparing of normal tissues. The necessary radiation doses and volumes need to be defined for the different extra-nodal lymphoma entities. The challenge is to optimise the use of radiotherapy in the modern multimodality treatment of extra...... not been carried out, and treatment decisions are made on small patient series and extrapolations from nodal lymphomas. Hopefully, wide international collaboration will make controlled clinical trials possible in the less common extra-nodal lymphomas. Modern highly conformal radiotherapy allows better...

  8. Effects of extra school-based physical education on overall physical fitness development

    DEFF Research Database (Denmark)

    Rexen, C T; Ersbøll, A K; Møller, N C

    2015-01-01

    First, this study aimed to investigate if four extra physical education (PE) lessons per week improved children's development in physical fitness. Second, to investigate if the extra PE lessons improved development in physical fitness for children with lower levels of fitness at baseline. This st......First, this study aimed to investigate if four extra physical education (PE) lessons per week improved children's development in physical fitness. Second, to investigate if the extra PE lessons improved development in physical fitness for children with lower levels of fitness at baseline...... = 536, extra PE = 711). Development in fitness was analyzed using a composite z-score from six fitness tests. Multilevel mixed-effects linear regression was used to examine the association between school type and development in fitness. Extra PE increased the total development of composite z-score units...

  9. Global constitutionalism, responsibility to protect, and extra-territorial obligations to realize the right to health: time to overcome the double standard (once again).

    Science.gov (United States)

    Ooms, Gorik; Hammonds, Rachel

    2014-10-10

    If human rights are "inalienable rights of all members of the human family", as is enshrined in the Universal Declaration of Human Rights, then no government should be allowed to deny people of them. When some governments fail to realize them for the people under their jurisdiction, the international community has a responsibility to step in. This extra-territorial effect of human rights was not included in the original conception of human rights. It is of recent date, and, in practice, limited to interventions to end severe violations of civil and political human rights. For economic, social and cultural human rights, extra-territorial obligations are still contested. In this paper, we elaborate three contentions: first, that the realization of social human rights requires the acceptance of and compliance with extra-territorial obligations; second, that compliance with extra-territorial obligations would help transform the international assistance paradigm from charity into legal obligation; and third, that for global constitutionalism to succeed in improving the fairness of the international legal order requires acceptance of the indivisibility of human rights.

  10. Dimensiones Extra y los Límites de la Física Dimensiones Extra y los Límites de la Física

    Directory of Open Access Journals (Sweden)

    Selim Gómez Ávila

    2012-02-01

    Full Text Available The history and cultural impact of extra dimensional models in physics is briefl y examined. Emphasis is put in the influence in the fine arts, and in particular the case of Marcel Duchamp is used as an example. Some perspectives of the study of extra dimensions aresketched.Se examina brevemente la historia y el impacto cultural de modelos de dimensiones extraen física. Se enfatiza la influencia en las bellas artes, y en particular el caso de Marcel Duchamp es usado como ejemplo. Se bosquejan algunas perspectivas del estudio de dimensiones extra.

  11. Correlates of extra-dyadic sex in Czech heterosexual couples: does sexual behavior of parents matter?

    Science.gov (United States)

    Havlicek, Jan; Husarova, Barbara; Rezacova, Veronika; Klapilova, Katerina

    2011-12-01

    Despite frequent sanctions and potentially serious consequences, extra-dyadic involvements are a relatively common phenomenon. Previously, potential links among extra-dyadic involvements and personal or interpersonal characteristics were extensively explored. However, the developmental aspects of extra-dyadic relationships have been rather overlooked to date. Here, we focus on the association between self-reported extra-dyadic tendencies and behavior, and previous experience with extra-dyadic sex in prior romantic relationships and in the primary family. We asked both members of 86 long-term cohabiting couples to complete several inventories assessing various aspects of the relationship satisfaction, sociosexuality and extra-dyadic intentions and behavior. As in previous studies, we found a lower level of overall Dyadic Adjustment and in the subscales Affectional Expression and Dyadic Consensus, in particular, among women but not men who reported extra-pair sex. Neither experience with own nor partners' infidelity in previous relationships was linked to reported extra-pair sex in the current relationship. However, men who reported their fathers but not mothers being unfaithful were also significantly more often unfaithful and showed a higher level of extra-dyadic intentions. There was no association between parental infidelity and extra-pair sex or extra-dyadic intentions in women. Our results suggest that experience of infidelity within the primary family has an impact on subsequent behavior. However, this is the case only in men. Women's extra-dyadic activities seem to be affected instead by the quality of the current relationship. Future research is needed to test the influence of ontogenetic and hereditary factors on the development of infidelity tendencies.

  12. Social Security Administration Data for Extra Help with Medicare Prescription Drug Plan Cost

    Data.gov (United States)

    Social Security Administration — This file contains information about Social Security determinations of eligibility for Extra Help with Medicare Prescription Drug Plan Costs. Specific data elements...

  13. Extra Molting and Selection on Nymphal Growth in the Desert Locust.

    Directory of Open Access Journals (Sweden)

    Benjamin Pélissié

    Full Text Available In insects, extra-molting has been viewed as a compensatory mechanism for nymphal growth that contributes to optimize body weight for successful reproduction. However, little is known on the capacity of extra-molting to evolve in natural populations, which limits our understanding of how selection acts on nymphal growth. We used a multi-generational pedigree, individual monitoring and quantitative genetics models to investigate the evolution of extra-molting and its impact on nymphal growth in a solitarious population of the desert locust, Schistocerca gregaria. Growth compensation via extra-molting was observed for 46% of the females, whose adult weight exceeded by 4% that of other females, at a cost of a 22% longer development time. We found a null heritability for body weight threshold only, and the highest and a strongly female-biased heritability for extra molting. Our genetic estimates show that (1 directional selection can act on growth rate, development time and extra-molting to optimize body weight threshold, the target of stabilizing selection, (2 extra-molting can evolve in natural populations, and (3 a genetic conflict, due to sexually antagonistic selection on extra-molting, might prevent its fixation. Finally, we discuss how antagonistic selection between solitarious and gregarious environments and/or genetic correlations between growth and phase traits might also impact the evolution of extra-molting in locusts.

  14. Using Supercomputers to Probe the Early Universe

    Energy Technology Data Exchange (ETDEWEB)

    Giorgi, Elena Edi [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-05-17

    For decades physicists have been trying to decipher the first moments after the Big Bang. Using very large telescopes, for example, scientists scan the skies and look at how fast galaxies move. Satellites study the relic radiation left from the Big Bang, called the cosmic microwave background radiation. And finally, particle colliders, like the Large Hadron Collider at CERN, allow researchers to smash protons together and analyze the debris left behind by such collisions. Physicists at Los Alamos National Laboratory, however, are taking a different approach: they are using computers. In collaboration with colleagues at University of California San Diego, the Los Alamos researchers developed a computer code, called BURST, that can simulate conditions during the first few minutes of cosmological evolution.

  15. Wide-field time-resolved luminescence imaging and spectroscopy to decipher obliterated documents in forensic science

    Science.gov (United States)

    Suzuki, Mototsugu; Akiba, Norimitsu; Kurosawa, Kenji; Kuroki, Kenro; Akao, Yoshinori; Higashikawa, Yoshiyasu

    2016-01-01

    We applied a wide-field time-resolved luminescence (TRL) method with a pulsed laser and a gated intensified charge coupled device (ICCD) for deciphering obliterated documents for use in forensic science. The TRL method can nondestructively measure the dynamics of luminescence, including fluorescence and phosphorescence lifetimes, which prove to be useful parameters for image detection. First, we measured the TRL spectra of four brands of black porous-tip pen inks on paper to estimate their luminescence lifetimes. Next, we acquired the TRL images of 12 obliterated documents at various delay times and gate times of the ICCD. The obliterated contents were revealed in the TRL images because of the difference in the luminescence lifetimes of the inks. This method requires no pretreatment, is nondestructive, and has the advantage of wide-field imaging, which makes it is easy to control the gate timing. This demonstration proves that TRL imaging and spectroscopy are powerful tools for forensic document examination.

  16. Deciphering transmissivity and hydraulic conductivity of the aquifer by vertical electrical sounding (VES) experiments in Northwest Bangladesh

    Science.gov (United States)

    Sattar, Golam Shabbir; Keramat, Mumnunul; Shahid, Shamsuddin

    2016-03-01

    The vertical electrical soundings (VESs) are carried out in 24 selective locations of Chapai-Nawabganj area of northwest Bangladesh to determine the transmissivity and hydraulic conductivity of the aquifer. Initially, the transmissivity and hydraulic conductivity are determined from the pumping data of nearby available production wells. Afterwards, the T and K are correlated with geoelectrical resistance and the total resistivity of the aquifer. The present study deciphers the functional analogous relations of the geoelectrical resistance with the transmissivity and the total resistivity with the hydraulic conductivity of the aquifer in northwest Bangladesh. It has been shown that the given equations provide reasonable values of transmissivity and hydraulic conductivity where pumping test information is unavailable. It can be expected that the aquifer properties viz. transmissivity and hydraulic conductivity of geologically similar area can be determined with the help of the obtained equations by conducting VES experiments.

  17. Color Doppler US in extra-articular rheumatoid arthritis. Early results; L'eco Doppler nell'artrite reumatoide con localizzazione extra-articolare: esperienza preliminare

    Energy Technology Data Exchange (ETDEWEB)

    Midiri, M. [Bari Politcenico, Bari (Italy). Ist. di Radiologia; Iovane, A.; Finazzo, M.; Brancatelli, G.; Gallo, C.; Lagalla, R. [Palermo Politecnico Universitario Paolo Giaccone, Palermo (Italy). Ist. di Radiologia

    1999-09-01

    The paper investigates the role of color and power Doppler imaging in staging extra-articular involvement, monitoring local inflammatory changes and drug treatment response. [Italian] Scopo del lavoro e' quello di analizzare l'introduzione dell'ecografia con color power Doppler, che offre possibilita' di integrazione dell'ecografia, con particolare riferimento alla dimostrazione del grado di coinvolgimento extra-articolare, allo stato evolutivo, della flogrosi locale e alla risposta al trattamento farmacologico.

  18. Deciphering effects of functional groups and electron density on azo dyes degradation by graphene loaded TiO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Qian [College of Chemical Engineering, HuaQiao University, Xiamen 361021 (China); Liang, Xiao [School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai 200093 (China); Chen, Bor-Yann [Department of Chemical and Materials Engineering, National I-Lan University, 26047, Taiwan (China); Chang, Chang-Tang, E-mail: ctchang@niu.edu.tw [Department of Environmental Engineering, National I-Lan University, 26047, Taiwan (China)

    2015-12-01

    Highlights: • The degradation pathways of RB5, RB171 and RR198 have been identified. • The favorable bond to be broken under photo degradation was deciphered in this research. • The breakages of the bonds were due to the electron density changes around the bonds. • The hydroxyl radicals as the main oxidized species were confirmed by positive hole trapper and ESR. - Abstract: This study tended to decipher the mechanism of photo degradation of azo dyes, which bond was favorable to be broken for application of wastewater decolorization. That is, from chemical structure perspective, the critical substituents to affect electron donor/acceptor for dye degradation would be identified in this research. The model reactive blacks (RB5), reactive blue 171 (RB171) and reactive red 198 (RR198) were degraded by graphene loaded TiO{sub 2}, indicating how the electron withdrawing and releasing groups affect azo dye degradability. The byproducts and intermediate products were analyzed by ultraviolet–visible spectroscopy (UV–vis), gas chromatography–mass spectrometry (GC–MS) and ion chromatography (IC). Furthermore, the radicals involved in the reaction were found by electron paramagnetic resonance (ESR) to confirm the main oxidized species of hydroxyl radicals rather than the light generated positive holes. The finding revealed that the breakages of the bonds were due to the electron density changes around the bonds. This principle can be applicable not only for RB5 degradation, but also for reactive blue 171 (RB171), reactive red 198 (RR198) and some other textile dyes.

  19. Doses due to extra-vehicular activity on space stations

    Energy Technology Data Exchange (ETDEWEB)

    Deme, S.; Apathy, I.; Feher, I. [KFKI Atomic Energy Research Institute, Budapest (Hungary); Akatov, Y.; Arkhanguelski, V. [Institute of Biomedical Problems, State Scientific Center, Moscow (Russian Federation); Reitz, G. [DLR Institute of Aerospace Medicine, Cologne, Linder Hohe (Germany)

    2006-07-01

    One of the many risks of long duration space flight is the dose from cosmic radiation, especially during periods of intensive solar activity. At such times, particularly during extra-vehicular activity (E.V.A.), when the astronauts are not protected by the wall of the spacecraft, cosmic radiation is a potentially serious health threat. Accurate dose measurement becomes increasingly important during the assembly of large space objects. Passive integrating detector systems such as thermoluminescent dosimeters (TLDs) are commonly used for dosimetric mapping and personal dosimetry on space vehicles. K.F.K.I. Atomic Energy Research Institute has developed and manufactured a series of thermoluminescent dosimeter systems, called Pille, for measuring cosmic radiation doses in the 3 {mu}Gy to 10 Gy range, consisting of a set of CaSO{sub 4}:Dy bulb dosimeters and a small, compact, TLD reader suitable for on-board evaluation of the dosimeters. Such a system offers a solution for E.V.A. dosimetry as well. By means of such a system, highly accurate measurements were carried out on board the Salyut-6, -7 and Mir Space Stations, on the Space Shuttle, and most recently on several segments of the International Space Station (I.S.S.). The Pille system was used to make the first measurements of the radiation exposure of cosmonauts during E.V.A.. Such E.V.A. measurements were carried out twice (on June 12 and 16, 1987) by Y. Romanenko, the commander of the second crew of Mir. During the E.V.A. one of the dosimeters was fixed in a pocket on the outer surface of the left leg of his space-suit; a second dosimeter was located inside the station for reference measurements. The advanced TLD system Pille 96 was used during the Nasa-4 (1997) mission to monitor the cosmic radiation dose inside the Mir Space Station and to measure the exposure of two of the astronauts during their E.V.A. activities. The extra doses of two E.V.A. during the Euromir 95 and one E.V.A. during the Nasa4 experiment

  20. Zhejiang University

    Institute of Scientific and Technical Information of China (English)

    玄之

    2008-01-01

    In September 1998,a new Zhejiang University was established on the basis of the amalgamation of the four former individual universities,namely Zhejiang University,Hangzhou University,Zhejiang Agricultural University and Zhejiang Medical University,which were all located in the garden city of Hangzhou.Approved by the State Council,the founding of the new Zhejiang University has been a significant move in the reform and development of China’s higher education.The four universities have grown out of the same ancestry,the Qiushi(with the literal meaning of "seeking truth" in Chinese) Academy,which was founded a century ago as one of the earliest institutions of higher learning in China.As a result,they have all inherited from it the spirit of "Qiushi" and at the same time,built up their owndistinctive features in teaching and research.

  1. Tendinopathy of the long head of the biceps tendon: histopathologic analysis of the extra-articular biceps tendon and tenosynovium

    Directory of Open Access Journals (Sweden)

    Streit JJ

    2015-03-01

    Full Text Available Jonathan J Streit,1 Yousef Shishani,1 Mark Rodgers,2 Reuben Gobezie1 1The Cleveland Shoulder Institute, 2Department of Pathology, University Hospitals of Cleveland, Cleveland, OH, USA Background: Bicipital tendinitis is a common cause of anterior shoulder pain, but there is no evidence that acute inflammation of the extra-articular long head of the biceps (LHB tendon is the root cause of this condition. We evaluated the histologic findings of the extra-articular portion of the LHB tendon and synovial sheath in order to compare those findings to known histologic changes seen in other tendinopathies. Methods: Twenty-six consecutive patients (mean age 45.4±13.7 years underwent an open subpectoral biceps tenodesis for anterior shoulder pain localized to the bicipital groove. Excised tendons were sent for histologic analysis. Specimens were graded using a semiquantitative scoring system to evaluate tenocyte morphology, the presence of ground substance, collagen bundle characteristics, and vascular changes. Results: Chronic inflammation was noted in only two of 26 specimens, and no specimen demonstrated acute inflammation. Tenocyte enlargement and proliferation, characterized by increased roundness and size of the cell and nucleus with proteoglycan matrix expansion and myxoid degenerative changes, was found in all 26 specimens. Abundant ground substance, collagen bundle changes, and increased vascularization were visualized in all samples. Conclusion: Anterior shoulder pain attributed to the biceps tendon does not appear to be due to an inflammatory process in most cases. The histologic findings of the extra-articular portion of the LHB tendon and synovial sheath are similar to the pathologic findings in de Quervain tenosynovitis at the wrist, and may be due to a chronic degenerative process similar to this and other tendinopathies of the body. Keywords: biceps tendinitis, biceps tendinopathy, tenosynovium, anterior shoulder pain, long head biceps

  2. Comparison of Extra-Amniotic Normal Saline Infusion plus Hydrocortisone versus Prostaglandin E2 Suppository for Pregnancy Termination

    Directory of Open Access Journals (Sweden)

    Farahnaz Keshavarzi

    2012-08-01

    Full Text Available Background and Aim: Pregnancy termination before onset of labor is one of the midwifery problems. The aim of the present study was to compare extra-amniotic normal saline infusion plus hydrocortisone effect versus prostaglandin E2 suppository for cervical ripening and second- trimester pregnancy termination.   Materials and Methods: This randomized clinical-trial study was performed on 50 pregnant women with gestation age of 14 to 28 weeks and Bishops Score ≤ 2 who required pregnancy termination for fetal indications. Half of the cases received extra-amniotic normal saline infusion plus 100 mg hydrocortisone (EASI+ H and the other half received two doses of 3mg prostaglandin E2 suppository every 4 hours. Six hours later, induction of labor was started by means of a high dose of Oxytocin according to of Alabama University Protocol for Mid-trimester Abortion. The obtained data was analyzed by using statistical softwares Chi-square, Fisher and T-test.   Results: There were no differences between the two groups regarding maternal age, parity, gestational age, Primary Bishops Score and indication of pregnancy termination. In the EASI+H group, the mean interval between initiation of labor induction and fetal expulsion was 23.04 ± 4.47 hours and in PGE2 group was 28.65 ± 2.87 hours (P=0.001. The success rate in the EASI+H group was 100% and in PGE2 group 80 % (P =0.04. Complications such as fever, nausea, vomiting, diarrhea, increase of blood pressure and need to curettage in PGE2 group were statistically and significantly more abundant.   Conclusion: Extra-amniotic normal saline infusion plus hydrocortisone is an effective and safe method that is suggested for cervical ripening and second- trimester pregnancy termination.

  3. The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites

    OpenAIRE

    Schneider, Christoph; Smith, David F; Cummings, Richard D.; Boligan, Kayluz Frias; Hamilton, Robert G.; Bochner, Bruce S; Miescher, Sylvia; Simon, Hans-Uwe; Pashov, Anastas; Vassilev, Tchavdar; von Gunten, Stephan

    2015-01-01

    Despite the paradigm that carbohydrates are T cell-independent antigens, isotype-switched glycan-specific IgG antibodies and polysaccharide-specific T cells are found in humans. We employed a systems level approach combined with glycan array technology to decipher the repertoire of carbohydrate-specific IgG antibodies in intravenous and subcutaneous immunoglobulin (IVIG/SCIG) preparations. A strikingly universal architecture of this repertoire with modular organization among different donor p...

  4. Fractal universe

    CERN Document Server

    Khokhlov, D L

    1999-01-01

    The model of the universe is considered in which background of the universe is not defined by the matter but is a priori specified as a homogenous and isotropic flat space. The scale factor of the universe follows the linear law. The scale of mass changes proportional to the scale factor. This leads to that the universe has the fractal structure with a power index of 2.

  5. Extra-intestinal amebiasis: clinical presentation in a non-endemic setting

    DEFF Research Database (Denmark)

    Thorsen, S; Rønne-Rasmussen, J; Petersen, E;

    1993-01-01

    37/38 patients with reciprocal titers > or = 512 against Entamoeba histolytica in Denmark over a 5-year period were evaluated retrospectively in order to establish the clinical profile of extra-intestinal amebiasis in a non-endemic area. 24 of these had extra-intestinal amebiasis, all presenting 1...

  6. Extra-axial ependymoma of posterior fossa extending to the Meckel's cave.

    Science.gov (United States)

    Torun, Fuat; Tuna, Hakan; Bozkurt, Melih; Deda, Haluk

    2005-06-01

    An extra-axial ependymoma extending from the left cerebellopontine corner to the Meckel's cave is reported. This lesion's clinical, radiological, and histological characteristics are presented. This tumor's infrequent extra-axial location, extension to the Meckel's cave and possible origin are discussed.

  7. Extra Virgin Olive Oil Lecture and Tasting at Dublin Institute of Technology, Cathal Brugha Street.

    OpenAIRE

    Cawley, Diarmuid

    2016-01-01

    Extra Virgin Olive Oil (EVOO) is synonymous with great taste, cookery, traditional Mediterranean cuisines and increasingly human health. As part of an ongoing series of extra-curricular events organised by the DIT FOOD FORUM, an interactive round table lecture and tutored tasting took place for a limited number of culinary students at the School of Culinary Arts, DIT.

  8. Weather conditions affect levels of extra-pair paternity in the reed bunting Emberiza schoeniclus

    NARCIS (Netherlands)

    Bouwman, KM; Komdeur, J

    2006-01-01

    Extra-pair paternity (EPP) is common in many socially monogamous birds, but large variations in frequency of EPP are found both between and within species. Local ecological factors can affect the costs and benefits of extra-pair mating behaviour, and may therefore influence the chance that individua

  9. No evidence of extra-pair paternity in a colonial seabird, the common tern (Sterna hirundo)

    DEFF Research Database (Denmark)

    Griggio, M.; Matessi, Giuliano; Marin, G.

    2004-01-01

    The incidence of extra-pair paternity and egg dumping was investigated in a colony of common terns (Sterna hirundo), a colonial seabird, in the Venetian lagoon. Ten families were sampled and multilocus DNA fingerprinting analysis was performed. No indication of extra-pair paternity or egg dumping...

  10. Superluminal neutrinos and extra dimensions: constraints from the null energy condition

    OpenAIRE

    Gubser, Steven S.

    2011-01-01

    In light of the recent results from the OPERA collaboration, indicating that neutrinos can travel superluminally, I review a simple extra-dimensional strategy for accommodating such behavior; and I also explain why it is hard in this strategy to avoid violating the null energy condition somewhere in the extra dimensions.

  11. Study on Extra-Cost Implications of Hospital Acquired Infection in ...

    African Journals Online (AJOL)

    Study on Extra-Cost Implications of Hospital Acquired Infection in Paediatric Patients in a Tertiary ... Log in or Register to get access to full text downloads. ... Compared to the matched uninfected controls, the mean extra length of stay, in days, ...

  12. Extra-Curricular Social Studies in an Open Air History Museum

    Science.gov (United States)

    Morris, Ronald Vaughan

    2008-01-01

    This article discusses extra-curricular social studies in an Open Air History Museum. Open Air History Museum, Conner Prairie Interpretive Park in Fishers, Indiana, is a cultural institution that encourages and supports talented students as they participate in an extra-curricular program. Ten-to sixteen-year-old youths "apply for jobs"…

  13. Evidence for extra radiation? Profile likelihood versus Bayesian posterior

    CERN Document Server

    Hamann, Jan

    2011-01-01

    A number of recent analyses of cosmological data have reported hints for the presence of extra radiation beyond the standard model expectation. In order to test the robustness of these claims under different methods of constructing parameter constraints, we perform a Bayesian posterior-based and a likelihood profile-based analysis of current data. We confirm the presence of a slight discrepancy between posterior- and profile-based constraints, with the marginalised posterior preferring higher values of the effective number of neutrino species N_eff. This can be traced back to a volume effect occurring during the marginalisation process, and we demonstrate that the effect is related to the fact that cosmic microwave background (CMB) data constrain N_eff only indirectly via the redshift of matter-radiation equality. Once present CMB data are combined with external information about, e.g., the Hubble parameter, the difference between the methods becomes small compared to the uncertainty of N_eff. We conclude tha...

  14. Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy

    Science.gov (United States)

    Sackey-Aboagye, Bridget; Olsen, Abby L.; Mukherjee, Sarmistha M.; Ventriglia, Alexander; Yokosaki, Yasuyuki; Greenbaum, Linda E.; Lee, Gi Yun; Naga, Hani

    2016-01-01

    Liver sinusoidal endothelial cells (LSECs) are the main endothelial cells in the liver and are important for maintaining liver homeostasis as well as responding to injury. LSECs express cellular fibronectin containing the alternatively spliced extra domain A (EIIIA-cFN) and increase expression of this isoform after liver injury, although its function is not well understood. Here, we examined the role of EIIIA-cFN in liver regeneration following partial hepatectomy. We carried out two-thirds partial hepatectomies in mice lacking EIIIA-cFN and in their wild type littermates, studied liver endothelial cell adhesion on decellularized, EIIIA-cFN-containing matrices and investigated the role of cellular fibronectins in liver endothelial cell tubulogenesis. We found that liver weight recovery following hepatectomy was significantly delayed and that sinusoidal repair was impaired in EIIIA-cFN null mice, especially females, as was the lipid accumulation typical of the post-hepatectomy liver. In vitro, we found that liver endothelial cells were more adhesive to cell-deposited matrices containing the EIIIA domain and that cellular fibronectin enhanced tubulogenesis and vascular cord formation. The integrin α9β1, which specifically binds EIIIA-cFN, promoted tubulogenesis and adhesion of liver endothelial cells to EIIIA-cFN. Our findings identify a role for EIIIA-cFN in liver regeneration and tubulogenesis. We suggest that sinusoidal repair is enhanced by increased LSEC adhesion, which is mediated by EIIIA-cFN. PMID:27741254

  15. Biological Activities of Phenolic Compounds of Extra Virgin Olive Oil

    Directory of Open Access Journals (Sweden)

    Maurizio Servili

    2013-12-01

    Full Text Available Over the last few decades, multiple biological properties, providing antioxidant, anti-inflammatory, chemopreventive and anti-cancer benefits, as well as the characteristic pungent and bitter taste, have been attributed to Extra Virgin Olive Oil (EVOO phenols. In particular, growing efforts have been devoted to the study of the antioxidants of EVOO, due to their importance from health, biological and sensory points of view. Hydrophilic and lipophilic phenols represent the main antioxidants of EVOO, and they include a large variety of compounds. Among them, the most concentrated phenols are lignans and secoiridoids, with the latter found exclusively in the Oleaceae family, of which the drupe is the only edible fruit. In recent years, therefore, we have tackled the study of the main properties of phenols, including the relationships between their biological activity and the related chemical structure. This review, in fact, focuses on the phenolic compounds of EVOO, and, in particular, on their biological properties, sensory aspects and antioxidant capacity, with a particular emphasis on the extension of the product shelf-life.

  16. Extra-intradural Spinal Meningioma: A Case Report.

    Science.gov (United States)

    Jeong, Seong Kyun; Seong, Han Yu; Roh, Sung Woo

    2014-09-01

    Extradural spinal meningiomas are uncommon, and their pathophysiology is not entirely understood. Here, we present the case of a 49-year-old woman with low back and left leg pain of 5 years duration. Magnetic resonance imaging revealed a mass, 1.8-cm in size, with rim enhancement in the spinal canal at the T12 level and extending into the left T12-L1 foramen. In the surgical field, the mass presented with the characteristics of an extra-intradural spinal meningioma. The patient underwent a T12 total laminectomy. A linear durotomy was performed at the midline, and the intradural portion was removed. The extradural portion was not separable from the adjacent dura and the left T12 root, and it was removed by dural excision. Pathological examination confirmed the diagnosis of psammomatous meningioma. We also conducted a literature review of similar cases. Based on our experience with this case, we believe that it is important to clearly distinguish extradural meningiomas from other types of tumors as misdiagnosis can change the operative plan. The long term prognosis of extradural meningiomas is not clear but total excision is thought to be essential.

  17. Anisotropic winds from close-in extra-solar planets

    CERN Document Server

    Stone, James M

    2008-01-01

    We present two-dimensional hydrodynamic models of thermally driven winds from highly irradiated, close-in extra-solar planets. We adopt a very simple treatment of the radiative heating processes at the base of the wind, and instead focus on the differences between the properties of outflows in multidimensions in comparison to spherically symmetric models computed with the same methods. For hot (T > 2 x 10^{4} K) or highly ionized gas, we find strong (supersonic) polar flows are formed above the planet surface which produce weak shocks and outflow on the night-side. In comparison to a spherically symmetric wind with the same parameters, the sonic surface on the day-side is much closer to the planet surface in multidimensions, and the total mass loss rate is reduced by almost a factor of four. We also compute the steady-state structure of interacting planetary and stellar winds. Both winds end in a termination shock, with a parabolic contact discontinuity which is draped over the planet separating the two shock...

  18. Synoptic and climatological aspects of extra-tropical cyclones

    Science.gov (United States)

    Leckebusch, G. C.

    2010-09-01

    Mid-latitude cyclones are highly complex dynamical features embedded in the general atmospheric circulation of the extra-tropics. Although the basic mechanisms leading to the formation of cyclones are commonly understood, the specific conditions and physical reasons triggering extreme, partly explosive development, are still under investigation. This includes also the identification of processes which might modulate the frequency and intensity of cyclone systems on time scales from days to centennials. This overview presentation will thus focus on three main topics: Firstly, the dynamic-synoptic structures of cyclones, the possibility to objectively identify cyclones and wind storms, and actual statistical properties of cyclone occurrence under recent climate conditions are addressed. In a second part, aspects of the interannual variability and its causing mechanisms are related to the seasonal predictability of extreme cyclones producing severe storm events. Extending the time frame will mean to deduce information on decadal or even centennial time periods. Thus, actual work to decadal as well as climatological variability and changes will be presented. In the last part of the talk focus will be laid on potential socio-economical impacts of changed cyclone occurrence. By means of global and regional climate modeling, future damages in terms of insured losses will be investigated and measures of uncertainty estimated from a multi-model ensemble analysis will be presented.

  19. A $U(3)$ Gauge Theory on Fuzzy Extra Dimensions

    CERN Document Server

    Kurkcuoglu, Seckin

    2016-01-01

    In this article, we explore the low energy structure of a $U(3)$ gauge theory over spaces with fuzzy sphere(s) as extra dimensions. In particular, we determine the equivariant parametrization of the gauge fields, which transform either invariantly or as vectors under the combined action of $SU(2)$ rotations of the fuzzy spheres and those $U(3)$ gauge transformations generated by $SU(2) \\subset U(3)$ carrying the spin $1$ irreducible representation of $SU(2)$. The cases of a single fuzzy sphere $S_F^2$ and a particular direct sum of concentric fuzzy spheres, $S_F^{2 \\, Int}$, covering the monopole bundle sectors with windings $\\pm 1$ are treated in full and the low energy degrees of freedom for the gauge fields are obtained. Employing the parametrizations of the fields in the former case, we determine a low energy action by tracing over the fuzzy sphere and show that the emerging model is abelian Higgs type with $U(1) \\times U(1)$ gauge symmetry and possess vortex solutions on ${\\mathbb R}^2$, which we discuss...

  20. A Model of Lepton Masses from a Warped Extra Dimension

    CERN Document Server

    Csáki, C; Grojean, Christophe; Grossman, Y

    2008-01-01

    In order to explain the non-hierarchical neutrino mixing angles and the absence of lepton flavor violating processes in the context of warped extra dimensions one needs to introduce bulk flavor symmetries. We present a simple model of lepton masses and mixings in RS models based on the A4 non-abelian discrete symmetry. The virtues of this choice are: (i) the natural appearance of the tri-bimaximal mixing pattern; (ii) the complete absence of tree-level flavor violations in the neutral sector; (iii) the absence of flavor gauge bosons; (iv) the hierarchies in the charged lepton masses are explained via wave-function overlaps. We present the minimal field content and symmetry breaking pattern necessary to obtain a successful model of this type. The bounds from electroweak precision measurements allow the KK mass scale to be as low as 3 TeV. Tree-level lepton flavor violation is absent in this model, while the loop induced mu -> e gamma branching fraction is safely below the experimental bound.

  1. Is the proton radius puzzle evidence of extra dimensions?

    Energy Technology Data Exchange (ETDEWEB)

    Dahia, F.; Lemos, A.S. [Universidade Federal da Paraiba, Department of Physics, Joao Pessoa, PB (Brazil)

    2016-08-15

    The proton charge radius inferred from muonic hydrogen spectroscopy is not compatible with the previous value given by CODATA-2010, which, on its turn, essentially relies on measurements of the electron-proton interaction. The proton's new size was extracted from the 2S-2P Lamb shift in the muonic hydrogen, which showed an energy excess of 0.3 meV in comparison to the theoretical prediction, evaluated with the CODATA radius. Higher-dimensional gravity is a candidate to explain this discrepancy, since the muon-proton gravitational interaction is stronger than the electron-proton interaction and, in the context of braneworld models, the gravitational potential can be hugely amplified in short distances when compared to the Newtonian potential. Motivated by these ideas, we study a muonic hydrogen confined in a thick brane. We show that the muon-proton gravitational interaction modified by extra dimensions can provide the additional separation of 0.3 meV between the 2S and 2P states. In this scenario, the gravitational energy depends on the higher-dimensional Planck mass and indirectly on the brane thickness. Studying the behavior of the gravitational energy with respect to the brane thickness in a realistic range, we find constraints for the fundamental Planck mass that solve the proton radius puzzle and are consistent with previous experimental bounds. (orig.)

  2. Is the proton radius puzzle an evidence of extra dimensions?

    CERN Document Server

    Dahia, F

    2015-01-01

    The proton charge radius inferred from muonic hydrogen spectroscopy is not compatible with the previous value given by CODATA-2010, which, on its turn, essentially relies on measurements of the electron-proton interaction. The proton's new size was extracted from the 2S-2P Lamb shift in the muonic hydrogen, which showed an energy excess of 0.3 meV in comparison to the theoretical prediction, evaluated with the CODATA radius. Higher-dimensional gravity is a candidate to explain this discrepancy, since the muon-proton gravitational interaction is stronger than the electron-proton interaction and, in the context of braneworld models, the gravitational potential can be hugely amplified in short distances when compared to the Newtonian potential. Motivated by these ideas, we study a muonic hydrogen confined in a thick brane. We show that the muon-proton gravitational interaction modified by extra dimensions can provide the additional separation of 0.3 meV between 2S and 2P states. In this scenario, the gravitation...

  3. Biological Activities of Phenolic Compounds of Extra Virgin Olive Oil.

    Science.gov (United States)

    Servili, Maurizio; Sordini, Beatrice; Esposto, Sonia; Urbani, Stefania; Veneziani, Gianluca; Di Maio, Ilona; Selvaggini, Roberto; Taticchi, Agnese

    2013-12-20

    Over the last few decades, multiple biological properties, providing antioxidant, anti-inflammatory, chemopreventive and anti-cancer benefits, as well as the characteristic pungent and bitter taste, have been attributed to Extra Virgin Olive Oil (EVOO) phenols. In particular, growing efforts have been devoted to the study of the antioxidants of EVOO, due to their importance from health, biological and sensory points of view. Hydrophilic and lipophilic phenols represent the main antioxidants of EVOO, and they include a large variety of compounds. Among them, the most concentrated phenols are lignans and secoiridoids, with the latter found exclusively in the Oleaceae family, of which the drupe is the only edible fruit. In recent years, therefore, we have tackled the study of the main properties of phenols, including the relationships between their biological activity and the related chemical structure. This review, in fact, focuses on the phenolic compounds of EVOO, and, in particular, on their biological properties, sensory aspects and antioxidant capacity, with a particular emphasis on the extension of the product shelf-life.

  4. Extra-Pulmonary Tuberculosis and Its Surgical Treatment.

    Science.gov (United States)

    Fry, Donald E

    2016-08-01

    Tuberculous infection has declined in the United States but remains a major infectious disease with morbidity and death for millions of people. Although the primary therapy is drugs, complications of the disease require surgical interventions. The published literature on tuberculosis was reviewed to provide a current understanding of the medical treatment of the disease and to define those areas where surgical intervention continues to be necessary. Multi-drug therapy for tuberculosis has become the standard and has reduced the complications of the disease necessitating surgical intervention. However, multi-drug resistance and extensively drug-resistant tuberculosis continue to be major problems and require effective initial therapy with surveillance to define resistant infections. The roles of surgery in tuberculosis are in establishing the diagnosis in extra-pulmonary infection and in the management of complications of disseminated disease. Tuberculosis remains an occupational risk for surgeons and surgical personnel. Tuberculosis is still a global problem, mandating recognition and treatment. Surgeons should have an understanding of the diverse presentation and complications of the disease.

  5. Extra virgin olive oil: from composition to "molecular gastronomy".

    Science.gov (United States)

    Sacchi, Raffaele; Paduano, Antonello; Savarese, Maria; Vitaglione, Paola; Fogliano, Vincenzo

    2014-01-01

    The aim of this chapter is to provide a brief overview of the recent results of studies on extra virgin olive oil (EVOO) and its interactions with other food ingredients during cooking, to highlight basic molecular aspects of the "magic" of EVOO and its role in Mediterranean gastronomy. The use of raw EVOO added to foods after cooking (or as a salad oil) is the best way to express the original flavour and to maximize the intake of natural antioxidants and compounds related to positive effects on human health (hypotensive, anti-inflammatory, and anti-cancerogenic, among others). EVOO, however, also exhibits its protective properties during/after cooking. Different chemical interactions between biophenolic compounds and other food ingredients (water, milk proteins, carotenoids of tomato, omega-3 polyunsaturated fatty acids in canned-in-oil fish and meat or fish proteins) occur. Even during cooking, EVOO exhibits strong antioxidant properties and influences the overall flavour of cooked foods. The physical (partitioning, emulsion) and chemical (hydrolysis, covalent binding, antioxidant properties) phenomena occurring during cooking of EVOO are discussed with emphasis on the changes in the sensory (bitterness and fruity flavour) and nutritional qualities of some traditional Mediterranean foods. In particular, tomato-oil interactions during cooking, fish canning in EVOO, meat marinated in EVOO before cooking and roasting and frying in EVOO are examined. The interactions between EVOO antioxidants and flavours with milk proteins are also briefly discussed.

  6. U (3 ) gauge theory on fuzzy extra dimensions

    Science.gov (United States)

    Kürkçüoǧlu, S.; Ünal, G.

    2016-08-01

    In this article, we explore the low energy structure of a U (3 ) gauge theory over spaces with fuzzy sphere(s) as extra dimensions. In particular, we determine the equivariant parametrization of the gauge fields, which transform either invariantly or as vectors under the combined action of S U (2 ) rotations of the fuzzy spheres and those U (3 ) gauge transformations generated by S U (2 )⊂U (3 ) carrying the spin 1 irreducible representation of S U (2 ). The cases of a single fuzzy sphere SF2 and a particular direct sum of concentric fuzzy spheres, SF2 Int , covering the monopole bundle sectors with windings ±1 are treated in full and the low energy degrees of freedom for the gauge fields are obtained. Employing the parametrizations of the fields in the former case, we determine a low energy action by tracing over the fuzzy sphere and show that the emerging model is Abelian Higgs type with U (1 )×U (1 ) gauge symmetry and possesses vortex solutions on R2, which we discuss in some detail. Generalization of our formulation to the equivariant parametrization of gauge fields in U (n ) theories is also briefly addressed.

  7. Extra-abdominal venous thromboses at unusual sites.

    Science.gov (United States)

    Martinelli, Ida; De Stefano, Valerio

    2012-09-01

    Venous thrombosis typically involves the lower extremities. Rarely, it can occur in cerebral, splanchnic, or renal veins, with a frightening clinical impact. Other rare manifestations are upper-extremity deep vein thrombosis, that can complicate with pulmonary embolism and post-thrombotic syndrome, and retinal vein occlusion, significantly affecting the quality of life. This review is focused on venous thromboses at unusual extra-abdominal sites. Local infections or cancer are frequent in cerebral sinus-venous thrombosis. Upper-extremity deep vein thrombosis is mostly due to catheters or effort-related factors. Common risk factors are inherited thrombophilia and oral contraceptive use. Acute treatment is based on heparin; in cerebral sinus-venous thrombosis, local or systemic fibrinolysis should be considered in case of clinical deterioration. Vitamin-K antagonists are recommended for 3-6 months; indefinite anticoagulation is suggested for recurrent thrombosis or unprovoked thrombosis and permanent risk factors. However, such recommendations mainly derive from observational studies; there are no data about long-term treatment of retinal vein occlusion.

  8. Large, Extra Dimensions at the Deep Underground Neutrino Experiment

    CERN Document Server

    Berryman, Jeffrey M; Kelly, Kevin J; Peres, O L G; Tabrizi, Zahra

    2016-01-01

    We investigate the potential of the long-baseline Deep Underground Neutrino Experiment (DUNE) to study large-extra-dimension (LED) models originally proposed to explain the smallness of neutrino masses by postulating that right-handed neutrinos, unlike all standard model fermion fields, can propagate in the bulk. The massive Kaluza-Klein (KK) modes of the right-handed neutrino fields modify the neutrino oscillation probabilities and can hence affect their propagation. We show that, as far as DUNE is concerned, the LED model is indistinguishable from a $(3 + 3N)$-neutrino framework for modest values of $N$; $N$ = 1 is usually a very good approximation. Nonetheless, there are no new sources of $CP$-invariance violation other than one $CP$-odd phase that can be easily mapped onto the $CP$-odd phase in the standard three-neutrino paradigm. We analyze the sensitivity of DUNE to the LED framework, and explore the capability of DUNE to differentiate the LED model from the three-neutrino scenario and from a generic $...

  9. Large extra dimensions at the Deep Underground Neutrino Experiment

    Science.gov (United States)

    Berryman, Jeffrey M.; de Gouvêa, André; Kelly, Kevin J.; Peres, O. L. G.; Tabrizi, Zahra

    2016-08-01

    We investigate the potential of the long-baseline Deep Underground Neutrino Experiment (DUNE) to study large-extra-dimension (LED) models originally proposed to explain the smallness of neutrino masses by postulating that right-handed neutrinos, unlike all standard model fermion fields, can propagate in the bulk. The massive Kaluza-Klein (KK) modes of the right-handed neutrino fields modify the neutrino oscillation probabilities and can hence affect their propagation. We show that, as far as DUNE is concerned, the LED model is indistinguishable from a (3 +3 N )-neutrino framework for modest values of N ; N =1 is usually a very good approximation. Nonetheless, there are no new sources of C P -invariance violation other than one C P -odd phase that can be easily mapped onto the C P -odd phase in the standard three-neutrino paradigm. We analyze the sensitivity of DUNE to the LED framework and explore the capability of DUNE to differentiate the LED model from the three-neutrino scenario and from a generic (3 +1 )-neutrino model.

  10. Genomic analysis of extra-intestinal pathogenic Escherichia coli urosepsis.

    Science.gov (United States)

    McNally, A; Alhashash, F; Collins, M; Alqasim, A; Paszckiewicz, K; Weston, V; Diggle, M

    2013-08-01

    Urosepsis is a bacteraemia infection caused by an organism previously causing an infection in the urinary tract of a patient, a diagnosis which has been classically confirmed by culture of the same species of bacteria from both blood and urine samples. Given the new insights afforded by sequencing technologies into the complicated population structures of infectious agents affecting humans, we sought to investigate urosepsis by comparing the genome sequences of blood and urine isolates of Escherichia coli from five patients with urosepsis. The results confirm the classical urosepsis hypothesis in four of the five cases, but also show the complex nature of extra-intestinal E. coli infection in the fifth case, where three distinct strains caused two distinct infections. Additionally, we show there is little to no variation in the bacterial genome as it progressed from urine to blood, and also present a minimal set of virulence genes required for bacteraemia in E. coli based on gene association. These suggest that most E. coli have the genetic propensity to cause bacteraemia.

  11. Pictorial essay: Vascular interventions in extra cranial head and neck

    Directory of Open Access Journals (Sweden)

    Suyash S Kulkarni

    2012-01-01

    Full Text Available Medicine is an ever changing field and interventional radiology (IR procedures are becoming increasingly popular because of high efficacy and its minimally invasive nature of the procedure. Management of disease processes in the extra cranial head and neck (ECHN has always been a challenge due to the complex anatomy of the region. Cross sectional imaging of the ECHN has grown and evolved tremendously and occupies a pivotal and integral position in the clinical management of variety of head and neck pathologies. Advances in angiographic technologies including flat panel detector systems, biplane, and 3-dimensional rotational angiography have consolidated and expanded the role of IR in the management of various ECHN pathologies. The ECHN is at cross roads between the origins of great vessels and the cerebral vasculature. Thorough knowledge of functional and technical aspects of neuroangiography is essential before embarking on head and neck vascular interventions. The vessels of the head and neck can be involved by infectious and inflammatory conditions, get irradiated during radiotherapy and injured due to trauma or iatrogenic cause. The ECHN is also a common site for various hypervascular neoplasms and vascular malformations, which can be treated with endovascular and percutaneous embolization. This pictorial essay provides a review of variety of ECHN pathologies which were managed by various IR procedures using different approaches.

  12. B-factory Signals for a Warped Extra Dimension

    CERN Document Server

    Agashe, K; Soni, A; Agashe, Kaustubh; Perez, Gilad; Soni, Amarjit

    2004-01-01

    We study predictions for B-physics in a class of models, recently introduced, with a non-supersymmetric warped extra dimension. In these models few ($\\sim 3$) TeV Kaluza-Klein masses are consistent with electroweak data due to bulk custodial symmetry. Furthermore, there is an analog of GIM mechanism which is violated by the heavy top quark (just as in SM) leading to striking signals at $B$-factories: (i) New Physics (NP) contributions to $\\Delta F= 2$ transitions are comparable to SM. This implies that, within this NP model, the success of the SM unitarity triangle fit is a ``coincidence''. Thus, clean extractions of unitarity angles via e.g. $B \\to \\pi \\pi,\\rho \\pi, \\rho \\rho, DK$ are likely to be affected, in addition to O(1) deviation from SM prediction in $B_s$ mixing. (ii) O(1) deviation from SM predictions for $B \\to X_s l^+ l^-$ in rate as well as in forward-backward and direct CP asymmetry. (iii) Large mixing-induced CP asymmetry in radiative B decays, wherein the SM unamibgously predicts very small a...

  13. Economics and ethics of paediatric respiratory extra corporeal life support.

    Science.gov (United States)

    Callaghan, M; Doyle, Y; O'Hare, B; Healy, M; Nölke, L

    2013-09-01

    Extra corporeal membrane oxygenation (ECMO) is a form of life support, which facilitates gas exchange outside the body via an oxygenator and a centrifugal pumping system. A paediatric cardiac ECMO programme was established in 2005 at Our Lady's Children's Hospital, Crumlin (OLCHC) and to date 75 patients have received ECMO, the majority being post operative cardiac patients. The outcome data compares favourably with international figures. ECMO has been most successful in the treatment of newborn infants with life threatening respiratory failure from conditions such as meconium aspiration, respiratory distress syndrome and respiratory infections. There is no formal paediatric respiratory ECMO programme at OLCHC, or anywhere else in Ireland. Currently, neonates requiring respiratory ECMO are transferred to centres in Sweden or the UK at an average cost of 133,000 Euros/infant, funded by the Health Service Executive E112 treatment abroad scheme. There is considerable morbidity associated with the transfer of critically ill infants, as well as significant psycho-social impact on families. OLCHC is not funded to provide respiratory ECMO, although the equipment and expertise required are similar to cardiac ECMO and are currently in place. The average cost of an ECMO run at OLCHC is 65,000 Euros. There is now a strong argument for a fully funded single national cardiac and respiratory paediatric ECMO centre, similar to that for adult patients.

  14. Dampak Integrative Leadership dan Employee Engagement terhadap Perilaku Extra-Role

    Directory of Open Access Journals (Sweden)

    Veronika Agustini Srimulyani

    2016-04-01

    Full Text Available Abstract. Organizations have long been interested in how employees think and feel about their jobs and what employees are willing to dedicate to the organization. Leadership style and employee engagement has been found to be positively related to extra-role b behavior and individual job performance. This study aims to analyze the influence of integrative leadership and employee engagement on extra-role b behavior, a case study of teacher in 27 particular high schools in Madiun, as many as 319 permanent teachers. The sampling method is quota sampling. The collection of primary data by cross sectional using questionnaires. The analysis is used multiple regression analysis. Results of multiple regression analysis showed that: 1 integrative leadership had significant and positive direct effect on extra-role behavior; 2 employee engagement had significant and positive effect on extra-role behavior. Keywords: integrative leadership, employee engagement, motivation, extra-role Behavior, job performance

  15. Ambiguity in running spectral index with an extra light field during inflation

    CERN Document Server

    Kohri, Kazunori

    2014-01-01

    At the beginning of inflation there could be extra dynamical scalar fields that will soon disappear (become static) before the end of inflation. In the light of multi-field inflation, those extra degrees of freedom may not change the prediction of the original spectrum of the curvature perturbation. One can remove such fields introducing extra number of e-foldings prior to $N_e\\sim 60$, however such extra e-foldings may make the trans-Planckian problem worse due to the Lyth bound. We show that such extra scalar fields can change the running of the spectral index to give correction of $\\pm 0.01$ without modifying other cosmological parameters. The ambiguity in the running of the spectral index, which could be generated by such additional dynamical fields, can be used to nullify the tension between BICEP2 and other experiments.

  16. Procura de Sinais de Dimensões Extras Universais em Colisões Próton-Antipróton

    Energy Technology Data Exchange (ETDEWEB)

    de Souza Santos, Angelo [Sao Paulo, IFT

    2012-01-01

    Models that predict the existence of extra spatial dimensions have been studied since the beginning of the 20th century. These models can incorporate gravity in the framework that describes the other interactions and they can present a number of interesting features such as a dark matter candidate. In this work, we explore the consequences of the Universal Extra Dimensions (UED) model by searching for the production of Kaluza-Klein particles whose decay chain leads to signature $\\mu^{\\pm}\\mu^{\\pm} + \\mathrm{jets} + \\met$. We employ the data set corresponding to an integrated luminosity of \\unit{7.3}{\\femto\\barn}$^{-1}$, collected by the \\dzero{} detector at a $p\\bar p$ collider at a center of mass energy of \\unit{1.96}{\\tera\\electronvolt}. Since no excess was observed in the data, we were able to set a lower limit on the compactification scale of $R^{-1}>260$ GeV in the model. This is the first study to impose a direct limit on the minimal UED model.

  17. University Internationalization and University Autonomy

    DEFF Research Database (Denmark)

    2016-01-01

    Turcan and Gulieva deepen our theoretical understanding of the process of university internationalisation by exploring the relationship between university internationalisation and university autonomy. They conjecture that the process of university internationalisation and its sustainability are d......, dissimilar, and sometimes conflicting dimensions of the financial, legal, organisational, staffing, and academic autonomy of the host country, are compromising key aspects of their own autonomy and core mission?...

  18. University of the West Indies Distance Teaching Experiment (UWIDITE). Report.

    Science.gov (United States)

    Lalor, Gerald C.; Marrett, Christine

    Since March 1983, the University of the West Indies has been conducting a distance teaching experiment that links its three campuses and the Extra Mural Centres in Antigua, Dominica, and St. Lucia by telecommunications. The network is used for interactive distance teaching and other types of teleconferences. A variety of modern audio and video…

  19. Deciphering The Hot Components in Symbiotic Variables: A Brave New Frontier

    Science.gov (United States)

    Sion, Edward

    We propose to investigate the physical properties of the hot components of symbiotic variable stars. They are binary star systems consisting of a red giant and a white dwarf (WD) orbiting each other close enough to interact. Material from the outflowing stellar wind of the red giant accretes onto the white dwarf, and an accretion disk may or may not form. Much of the outflowing red giant wind material forms a large nebula around the binary that is partially ionized by radiation from the accreting WD and from thermonuclear burning at its surface. The exact nature of the hot component, the efficiency of such wind-fed accretion, the rate of accretion onto the WD, whether accretion disks are even present, and why the hot components are so much hotter than their cataclysmic variable cousins, all remain poorly know. All previous attempts to determine WD temperatures, luminosities and accretion rates relied upon the modified Zanstra method and crude black body fitting. To deepen our understanding of the hot components, we propose to apply synthetic spectra for high gravity stars and accretion disks generated from state-of-the-art computer codes to the far ultraviolet archival spectra of 40 symbiotic stars, obtained with the International Ultraviolet Explorer (IUE) and Far Ultraviolet Spectroscopic Explorer (FUSE) spacecrafts. Since the WD is the most common end-product of stellar evolution ( > 95% of all the stars in the Galaxy evolve into white dwarfs), and the accretion disk whether from wind- fed accretion or Roche lobe overflow, is the most common universal structure resulting from mass transfer with angular momentum, and since both can be directly viewed in CVs in the ultraviolet (UV), an understanding of the consequences of accretion in these systems is the first step in a global understanding of accretion in other systems throughout the universe. These include protostellar objects, X-ray binaries (containing neutron star and black hole accretors), active galactic

  20. Interpenetrating subspaces as a funnel to extra space

    CERN Document Server

    Rubin, Sergey G

    2016-01-01

    New solution for two interpenetrating universes is found. Higher derivative gravity acting in 6-dimensional space is the basis of the study that allows to obtain stable solution without introducing matter of any sort. Stability of the solution is maintained by a difference between asymptotic behavior at spacial infinities. For an external observer such a funnel looks similar to a spherical wormhole.

  1. The Extra-Curricular Perspective: The Moot Court.

    Science.gov (United States)

    Crouse, Janice Shaw; Thorpe, Judie Mosier

    At Ball State (Indiana) University, the moot court format's replication of real-world advocacy has been found far more conducive to teaching ethics and values than debate because it provides internal monitoring devices and instantaneous feedback. Of course, the main purpose of the moot court is to polish communication skills. Still, even with this…

  2. Interpenetrating subspaces as a funnel to extra space

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, Sergey G., E-mail: sergeirubin@list.ru

    2016-08-10

    New solution for two interpenetrating universes is found. Higher derivative gravity acting in 6-dimensional space is the basis of the study that allows to obtain stable solution without introducing matter of any sort. Stability of the solution is maintained by a difference between asymptotic behavior at spacial infinities. For an external observer such a funnel looks similar to a spherical wormhole.

  3. Early Psychosocial Stress Predicts Extra-Pair Copulations

    Directory of Open Access Journals (Sweden)

    Nicole Koehler

    2007-01-01

    Full Text Available Cheating on a mate, known as an extra-pair copulation (EPC, is considered unacceptable by most individuals. Nonetheless many individuals engage in such risky behaviors. Because individuals with high, as opposed to low, levels of early psychosocial stress are more risk prone and more likely to engage in opportunistic matings, we predicted that individuals reporting EPCs, one of many types of opportunistic mating (e.g., one-night stand, consecutive short-term relationships etc, have higher levels of early psychosocial stress than those who do not. Two types of EPCs were examined: EPC-self (EPC-S, having sex with someone other than one's mate, and EPC-other (EPC-O, having sex with someone else's mate. In a sample of 229 women and 161 men, significantly higher levels of early psychosocial stress were found amongst those reporting an EPC-S than those reporting none, irrespective of EPC-Os. Furthermore, the more EPC-Ss men, but not women, reported the higher their early psychosocial stress. Early psychosocial stress was not associated with EPC-Os irrespective of EPC-Ss. Participants were also classified into one of four groups (no EPCs, EPC-O only, EPC-S only, or EPC-S&O which significantly interacted with early psychosocial stress. Results are discussed from adaptationist and mechanist perspectives and why early psychosocial stress was higher in individuals reporting EPC-Ss irrespective of EPC-Os, but not EPC-Os irrespective of EPC-Ss, than those not reporting the EPC of interest.

  4. [Pleuropulmonary metastases originating from extra-thoracic neoplasia].

    Science.gov (United States)

    Badri, Farid; Batahar, Salma Ait; Idrissi, Safae El; Sajiai, Hafsa; Serhane, Hind; Amro, Lamyae

    2017-01-01

    The lungs receive the entire venous drainage of the body. This explains the high incidence of pleuropulmonary metastases originating from several cancers. The goal of this is to study the clinical manifestations of pleuro-pulmonary metastases originating from extra-thoracic cancers. We conducted a retrospective study of patients with pleuro-pulmonary metastasis whose data were collected in our department between January 2006 and december 2014. 76 patient medical records were studied. The average age was 50 years (aged 21-89 years) with a male predominance in 57.8% of cases. Clinical symptoms were mainly cough (32.8% of cases), dyspnea (23.7% of cases) and hemoptysis (11.2%). Primary cancers responsible for various pleuro-pulmonary metastases found in our case series were dominated by breast cancers in 27.6% of cases, gastro-intestinal cancers in 15.8% of cases, genital cancers in 9, 2% of cases, sarcomas in 7.8% of cases, renal cancers in 5.2% of cases, bladder cancers in 5.2% of cases, prostate cancers in 3.9% cases, ENT cancers in 3.9% of cases, thyroid cancers in 3.9% of cases, skin cancers in 2.6% of cases and cancers of unknown primary origin in 14.4% of cases respectively. Several radiologic features of pleuro-pulmonary metastases have been found in our case series; they can be isolated or combined. The most common radiologic aspect was multiple pulmonary nodules in 52.6% of cases, followed by pleurisies in 34.2% of cases, diffuse micronodules in 23.6% of cases and a solitary nodule in 3.94% of cases. Secondary pleuropulmonary cancers are frequent. They come in 3rd place after lymph nodes and liver metastases and are found in 30% of autopsies of patients with neoplasia.

  5. Extra flat, flexible and disposable endoscope for lateral imaging

    Science.gov (United States)

    Basset, G.; Marinov, D.; Hofer, C.; Cattaneo, S.; Volet, P.; Gallinet, B.; Schnieper, M.; Ferrini, R.

    2016-03-01

    We present an innovative disposable endoscope based on extra flat flexible polymer slabs used as multimode waveguides. The waveguides are compatible with low-cost roll-to-roll production technologies and can be easily customized by patterning, coating and printing techniques according to the specifications of the target application. In order to couple the light (i.e. the illumination beam and the imaging beam) in and out of the waveguide, diffractive subwavelength gratings are used. These nano-scale optical structures enable an efficient and controlled light trapping by total internal reflection, thus minimizing the distortion effects generated by the rough edges. Nano-patterning is obtained using established techniques (i.e. hot embossing and/or UV casting) that are compatible with industrial roll-to-roll production lines or plastic injection molding. Unique features of these innovative endoscopes are i) the achievable very thin form that can be reduced to thicknesses below 200 μm, ii) the ability to record lateral images with respect to the endoscope direction, iii) the ability to image samples (e.g. tissues, tiny objects) in direct contact with the polymer slab, with a minimum imaging distance equal to zero, and iv) the access to high volume fabrication techniques that can enable the production of low-cost disposable endoscopes. A possible device implementation is demonstrated and tested, which consists of a flat line-scanning endoscope enabling the acquisition of 1D images in monochromatic illumination and the reconstruction of 2D images by scanning. Images taken with such a disposable endoscope are discussed and the related technological constraints such as manufacturing tolerances, image distortion, scattered light and signal to noise ratio are further described. Finally, advantages and disadvantages with respect to other endoscopic techniques will be discussed, thus demonstrating the potential of this innovative approach for endoscopic applications in very

  6. Applying Biomimetic Algorithms for Extra-Terrestrial Habitat Generation

    Science.gov (United States)

    Birge, Brian

    2012-01-01

    The objective is to simulate and optimize distributed cooperation among a network of robots tasked with cooperative excavation on an extra-terrestrial surface. Additionally to examine the concept of directed Emergence among a group of limited artificially intelligent agents. Emergence is the concept of achieving complex results from very simple rules or interactions. For example, in a termite mound each individual termite does not carry a blueprint of how to make their home in a global sense, but their interactions based strictly on local desires create a complex superstructure. Leveraging this Emergence concept applied to a simulation of cooperative agents (robots) will allow an examination of the success of non-directed group strategy achieving specific results. Specifically the simulation will be a testbed to evaluate population based robotic exploration and cooperative strategies while leveraging the evolutionary teamwork approach in the face of uncertainty about the environment and partial loss of sensors. Checking against a cost function and 'social' constraints will optimize cooperation when excavating a simulated tunnel. Agents will act locally with non-local results. The rules by which the simulated robots interact will be optimized to the simplest possible for the desired result, leveraging Emergence. Sensor malfunction and line of sight issues will be incorporated into the simulation. This approach falls under Swarm Robotics, a subset of robot control concerned with finding ways to control large groups of robots. Swarm Robotics often contains biologically inspired approaches, research comes from social insect observation but also data from among groups of herding, schooling, and flocking animals. Biomimetic algorithms applied to manned space exploration is the method under consideration for further study.

  7. Analysis on management of philanthropic endowment in Chinese universities

    Institute of Scientific and Technical Information of China (English)

    MENG Dong-jun; WU Ying-jun; ZHANG Mei-feng

    2005-01-01

    Philanthropic endowment, along with government allocation, tuition fee and extra income, is one of the four major means for funding higher education in China. Research on philanthropic endowment is at its beginning stage, and so it is not yet well known. With a view to providing some useful information to our government, universities and society, this paper aims at making a brief analysis of the status quo and management of philanthropic endowment in Chinese universities.

  8. Stanford University

    Institute of Scientific and Technical Information of China (English)

    李琳

    2007-01-01

    The Leland Stanford Junior University,commonly known as Stanford University (or simply Stanford),is a private university located approximately 37 miles (60 kilometers) southeast of San Francisco and approximately 20 miles northwest of San Joséin an unincorporated area of Santa Clara County.Situated adjacent to the city of Palo Alto,California,Stanford lies at the heart of the Silicon Valley,both geographically and historically.

  9. Decipher the short-distance component of $X(3872)$ in $B_c$ decays

    CERN Document Server

    Wang, Wei

    2015-01-01

    A foremost task in understanding the nature of the $X(3872)$ involves the discrimination of the two-quark and multiquark configurations. In this work, we propose a method to probe the short-distance component of the $X(3872)$ by measuring the ratio between the $B_c$ semileptonic and nonleptonic decays into the $X(3872)$. We demonstrate that if the $X(3872)$ production mechanism is through the $\\bar cc$ component, the ratios would be universal and could be reliably predicted in theory. Measurements of these ratios at LHC and the next-generation electron-positron colliders are capable of validating/invalidating this production mechanism and providing deeper insights into the nature of the $X(3872)$.

  10. Extra-pair young in house wren broods are more likely to be male than female.

    Science.gov (United States)

    Johnson, L Scott; Thompson, Charles F; Sakaluk, Scott K; Neuhäuser, Markus; Johnson, Bonnie G P; Soukup, Sheryl Swartz; Forsythe, Shannon Janota; Masters, Brian S

    2009-06-22

    Sex-allocation theory predicts that females should preferentially produce offspring of the sex with greater fitness potential. In socially monogamous animal species, extra-pair mating often increases the variance in fitness of sons relative to daughters. Thus, in situations where offspring sired by a female's extra-pair mate(s) will typically have greater fitness potential than offspring sired by the within-pair mate, sex-allocation theory predicts that females will bias the sex of offspring sired by extra-pair mates towards male. We examined the relationship between offspring sex and paternity over six breeding seasons in an Illinois population of the house wren (Troglodytes aedon), a cavity-nesting songbird. Out of the 2345 nestlings that had both sex and paternity assigned, 350 (15%) were sired by extra-pair males. The sex ratio of extra-pair offspring, 0.534, was significantly greater than the sex ratio of within-pair offspring, 0.492, representing an increase of 8.5 per cent in the proportion of sons produced. To our knowledge, this is the first confirmed report of female birds increasing their production of sons in association with extra-pair fertilization. Our results are consistent with the oft-mentioned hypothesis that females engage in extra-pair mating to increase offspring quality.

  11. Study of quantum mechanical scattering in presence of an extra compact space dimension

    CERN Document Server

    Deb, Ram Narayan

    2014-01-01

    It is well known that string theory generates the idea of higher dimensional spacetime instead of the (3+1) dimensions, in which we seem to live. It indicates that the extra space dimensions may remain curled up into very small space. In this paper, we study quantum mechanical scattering in presence of extra compact space dimension in the hope of devising a method to get a clue to the presence of extra space dimension. We consider a simplified model of scattering, in which a beam of free particles is scattered due to a one dimensional Dirac-delta potential in presence of an extra compact space dimension. We find that the incident, reflected and transmitted probability current densities of the particles contain the information of the extra dimension. Thus, by measuring experimentally the reflected and transmitted probability current densities of the particles, we may confirm the presence of extra dimension. We also show that the idea of compactification of the extra dimensions gives rise to the quantization of...

  12. Clinico-pathological signiifcance of extra-nodal spread in special types of breast cancer

    Institute of Scientific and Technical Information of China (English)

    Ecmel Isik Kaygusuz; Handan Cetiner; Hulya Yavuz

    2014-01-01

    Objective: To investigate the signiifcance of extra-nodal spread in special histological sub-types of breast cancer and the relationship of such spread with prognostic parameters. Methods: A total of 303 breast cancer cases were classiifed according to tumor type, and each tumor group was subdivided according to age, tumor diameter, lymph node metastasis, extra-nodal spread, vein invasion in the adjacent soft tissue, distant metastasis, and immunohistochemical characteristics [estrogen receptor (ER), progesterone receptor (PR) existence, p53, c-erbB-2, and proliferative rate (Ki-67)]. hTe 122 cases with extra-nodal spread were clinically followed up. Results: An extra-nodal spread was observed in 40% (122 cases) of the 303 breast cancer cases. hTe spread most frequently presented in micro papillary carcinoma histological sub-type (40 cases, 75%), but least frequently presents in mucinous carcinoma (2 cases, 8%). Patients with extra-nodal spread had a high average number of metastatic lymph nodes (8.3) and a high distant metastasis rate (38 cases, 31%) compared with patients without extra-nodal spread. Conclusion: hTe existence of extra-nodal spread in the examined breast cancer sub-types has predictive value in forecasting the number of metastatic lymph nodes and the disease prognosis.

  13. Relation of sulfur with hydrocarbons in Brazilian heavy and extra-heavy crude oil; Relacao do enxofre com os hidrocarbonetos em petroleos pesados e extra pesados brasileiros

    Energy Technology Data Exchange (ETDEWEB)

    Iorio, Sonia Maria Badaro Mangueira; Guimaraes, Regina Celia Lourenco; Silva, Maria do Socorro A. Justo da [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil); Costa, Alexander Vinicius Moraes da [Fundacao Gorceix, Ouro Preto, MG (Brazil)

    2008-07-01

    As the occurrence of heavy and extra-heavy oils increases sensitively, their participation in the refineries feeding also becomes greater. Heavy oils usually have lower price than a light one, because they produce lower quality derivatives and it's more difficult to meet the specifications. Crude oils are a complex mixture, mostly compounded by carbon and hydrogen and also by impurities like sulfur, nitrogen, oxygen and metals. Sulfur is the third most abundant component of crude oils, following carbon and hydrogen. In general there is a strong positive correlation between the concentrations of polar compounds (aromatics, resins and asphaltenes), and the sulfur content. This work presents graphically sulfur content and polar compounds concentrations for Brazilian and foreign heavy and extra-heavy oils (< 20 deg API). The results of the data analysis indicate that Brazilian crude oils behave differently from foreign heavy and extra-heavy oils. (author)

  14. Running of soft parameters in extra space-time dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, Tatsuo; Kubo, Jisuke; Mondragon, Myriam; Zoupanos, George

    1999-06-14

    The evolution of the parameters including those in the soft supersymmetry-breaking (SSB) sector is studied in the minimal supersymmetric standard model (MSSM) with a certain set of Kaluza-Klein towers which has been recently considered by Dienes et al. We use the continuous Wilson renormalization group technique to derive the one-loop matching condition between the effective, renormalizable and original, unrenormalizable theories. We investigate whether the assumption of a large compactification radius in the model is consistent with the gauge coupling unification, the b-{tau} unification and the radiative breaking of the electroweak gauge symmetry with the universal SSB terms. We calculate the superpartner spectrum under the assumption of the universal SSB parameters to find differences between the model and the MSSM.

  15. Interpenetrating subspaces as a funnel to extra space

    Directory of Open Access Journals (Sweden)

    Sergey G. Rubin

    2016-08-01

    Full Text Available New solution for two interpenetrating universes is found. Higher derivative gravity acting in 6-dimensional space is the basis of the study that allows to obtain stable solution without introducing matter of any sort. Stability of the solution is maintained by a difference between asymptotic behavior at spacial infinities. For an external observer such a funnel looks similar to a spherical wormhole.

  16. Grey extra-deleting theory-based governor control for hydro-generator unit

    Directory of Open Access Journals (Sweden)

    Ming-dong Wang

    2015-10-01

    Full Text Available The control effect by using the conventional method is not satisfied because of the grey character caused from time-variant parameters of hydro-generator units and its governor. The grey extra-deleting control theory is applied to the governor design of hydro-generator units in this paper. After the mathematic model of hydro-generator and its governor are founded, the grey extra-deleting controller is designed and its effect is studied compared with the conventional proportional–integral–derivative governor. The simulation results indicate that the grey extra-deleting controller can improve dynamic characteristic of hydro-generator units.

  17. On aether terms in a space-time with a compact extra dimension

    CERN Document Server

    Mariz, T; Petrov, A Yu

    2016-01-01

    In this paper, for the CPT-even and CPT-odd extensions of the QED, we explicitly obtain the aether-like corrections for the electromagnetic field in the case when the space-time involves an extra compact spatial dimension besides of usual four dimensions. Our methodology is based on an explicit summation over the Kaluza-Klein tower of fields which is no more difficult than the finite-temperature calculations. The quantum corrections turn out to be large as the extra dimension is small. We demonstrate that in the CPT-even case, the extra dimension manifests itself through a new scalar particle.

  18. Extra-pair paternity in the long-tailed finch Poephila acuticauda

    Directory of Open Access Journals (Sweden)

    Erica P. van Rooij

    2016-01-01

    Full Text Available Although the majority of passerine birds are socially monogamous, true genetic monogamy is rare, with extra-pair paternity (EPP occurring in almost 90% of surveyed socially monogamous species. We present the first molecular data on the genetic breeding system of the long-tailed finch, Poephila acuticauda, a grass finch endemic to the tropical northern savannah of Australia. Although the species forms socially monogamous pair bonds during the breeding season, we found that extra-pair males sired 12.8% of 391 offspring, in 25.7% of 101 broods. Our findings provide only the second estimate of extra-pair paternity in the estrildid finch family.

  19. COMPLEMENTARY SERVICES AND COMPLEMENTARY AND EXTRA-SCHOOL ACTIVITIES: AN EDUCATIONAL AND TRAINING NEED

    Directory of Open Access Journals (Sweden)

    Gisela Morales Navarro

    2009-04-01

    Full Text Available This writing has three targets. Firstly, our aim is to establish the difference between complementary and extra-school activities, because there is confusion according to regulations. Secondly, to know if extra-school activities complement the education and formation learnt in our Educational System, and, therefore, to illuminate if they are necessary in order to reach a well-rounded education. And, finally, to analyze in what way these extra-school activities and complementary services can damage educational equity and social cohesion in schools or, on the other hand, if these activities and services suit them.

  20. Universal structural estimator and dynamics approximator for complex networks

    CERN Document Server

    Chen, Yu-Zhong

    2016-01-01

    Revealing the structure and dynamics of complex networked systems from observed data is of fundamental importance to science, engineering, and society. Is it possible to develop a universal, completely data driven framework to decipher the network structure and different types of dynamical processes on complex networks, regardless of their details? We develop a Markov network based model, sparse dynamical Boltzmann machine (SDBM), as a universal network structural estimator and dynamics approximator. The SDBM attains its topology according to that of the original system and is capable of simulating the original dynamical process. We develop a fully automated method based on compressive sensing and machine learning to find the SDBM. We demonstrate, for a large variety of representative dynamical processes on model and real world complex networks, that the equivalent SDBM can recover the network structure of the original system and predicts its dynamical behavior with high precision.