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Sample records for david keil framingham

  1. David Huffman

    Indian Academy of Sciences (India)

    earned a bachelor's degree in Electrical Engineering at the age of 18. ... whose innovative thinking forms the technical underpinnings for the accoutrements of ... Gary Stix, Profile: David A Huffman, Scientific American, September 1991. ... At some point, Huffman is reported to have exchanged paper writing for paper folding.

  2. David Huebner

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Less than one year after becoming the chaiman of Coudert Brothers LLP,David Huebner made his second visit to Beijing in March to celebrate the firm's 25 years presence in China,Coudert began operations from an office in the Beijing Hotel in 1979,at the request of the Beijing Municipal Government to teach its officials foreign trade law.The one-man show has since evolved into a multicultural legal staff of 80 lawyers,with the landmark being the obtaining of the No.001 license from the Ministry of Justice of the People's Republic of China in 1992 to become the first foreign law firm to open an hourly billing rate of US$500 when practicing law,explains to CIB the significance of the 25 years' mark,and the future direction of his firm in China.

  3. David Brandner | NREL

    Science.gov (United States)

    David Brandner David Brandner Research Technician III-Chemical Engineering David.Brandner@nrel.gov chemical reaction engineering and transport phenomena Analytical analysis of complex bio-derived samples and Lignin Areas of Expertise Analytical analysis of complex samples Chemical reaction engineering and

  4. Hello, David! / Vladlen Livshits

    Index Scriptorium Estoniae

    Livshits, Vladlen

    2005-01-01

    Autori kohtumisest silmapaistva ameerika ajakirjaniku ja kirjaniku David Shipleriga Kohtla-Järvel 1978. aastal, ameerika matemaatiku Benoit Mandelbroti fraktaalse geomeetria teooriast, Lea Livshitsi maalidest

  5. Maria Keil, uma operária das artes (1914-2012). Arte Portuguesa do século XX

    OpenAIRE

    Mantas, Helena Alexandra Jorge Soares

    2013-01-01

    Tese de doutoramento em Letras, área de História, na especialidade de História da Arte, apresentada à Faculdade de Letras da Universidade de Coimbra Estudar a vida e a obra de Maria Keil é analisar a História e a Arte Portuguesas desde a década de 1930, quando a autora começou a sua actividade, até 2012, ano em que faleceu. Tendo desenvolvido obra em diversas áreas artísticas, destacando-se as artes gráficas, publicidade, ilustração, azulejaria, desenho e pintura, Maria Keil defin...

  6. ASPECTOS TAXONÔMICOS, FITOGEOGRÁFICOS E USOS DE Pectis uniaristata DC. var. jangadensis (S.Moore) Keil (ASTERACEAE)

    OpenAIRE

    PEREIRA, ARILDO GONÇALO; NETO, GERMANO GUARIM

    2014-01-01

    Este trabalho discute os aspectos taxonômicos, fitogeográficos e outros relacionados à Pectis uniaristata var. jangadensis (S. Moore) Keil (Asteraceae) uma planta de ocorrência na vegetação do cerrado e do pantanal de Mato Grosso.

  7. The essential David Bohm

    CERN Document Server

    Nichol, Lee

    2002-01-01

    There are few scientists of the twentieth century whose life's work has created more excitement and controversy than that of physicist David Bohm (1917-1992). For the first time in a single volume, The Essential David Bohm offers a comprehensive overview of Bohm's original works from a non-technical perspective. Including three chapters of previously unpublished material, and a forward by the Dalai Lama, each reading has been selected to highlight some aspect of the implicate order process, and to provide an introduction to one of the most provocative thinkers of our time.

  8. Interview with David Moore

    Science.gov (United States)

    Rossman, Allan; Dietz, E. Jacquelin; Moor, David

    2013-01-01

    David Moore is Professor Emeritus of Statistics at Purdue University. He served as the first President of the International Association for Statistical Education (IASE) from 1993-1995 and as President of the American Statistical Association (ASA) in 1998. He is a Fellow of the ASA and of the IMS and was awarded the ASA's Founders Award in…

  9. David Hockney Portraits

    NARCIS (Netherlands)

    Howgate, S.; Stern Shapiro, B.

    2007-01-01

    David Hockney is one of the most significant artists exploring and pushing the boundaries of figurative art today. He has been engaged with portraiture since his teenage years, when he painted Portrait of My Father (1955), and portraits of family, lovers, friends and well-known subjects represent an

  10. Conversation with David Claman

    OpenAIRE

    Moore, Tom

    2010-01-01

    Composer David Claman is presently professor of music in the Department of Music of Lehman College of the City University of New York. Recent commissions include music for The Da Capo Chamber Players and the CYGNUS Ensemble. Claman studied composition at the University of Colorado at Boulder and at Princeton University.

  11. Discussion 2: David Dobbs

    OpenAIRE

    Dobbs, David; Murray-Rust, Peter; Hatcher, Jordan; Pollock, Rufus

    2010-01-01

    David Dobbs writes on science, medicine and culture. He has contributed to a diversity of publications, including Scientific American, Slate magazine, Wired, Audubon, Atlantic Monthly, and the New York Times magazine. He has also authored a number of books. Other participants in this discussion were Peter Murray-Rust, Jordan Hatcher, and Rufus Pollock.

  12. David Bowie's Hauntology

    DEFF Research Database (Denmark)

    Christiansen, Steen Ledet

    David Bowie's now-defunct rock-opera trilogy's first installment 1. Outside is filled with uncanny mediations of rock music's chameleon. The inner sleeve booklet is titled The Diary of Nathan Adler, or the Ritual Art-Murder of Baby Grace Blue: A non-linear Gothic Drama Hyper-Cycle. Behind this long...

  13. David R Syiemlieh

    Indian Academy of Sciences (India)

    Union Public Service Commission, New Delhi. David R. Syiemlieh, formally a historian, joined as a Professor in the Department of History, NEHU, Shillong, in 1979. Concurrent with this position, he held at different times, Dean of Students' Welfare, Proctor, Director, College Development Council, and Head, Department of ...

  14. David, Dr Joy Caesarina

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1982 Section: Medicine. David, Dr Joy Caesarina M.B.B.S., M.S. (Madras). Date of birth: 3 May 1927. Date of death: 20 April 2004. Specialization: Neuropharmacology Last known address: 292, 4th Main, 1st Block, Koramangala, Bengaluru 560 034. YouTube; Twitter; Facebook ...

  15. David Macaulay's Pyramid.

    Science.gov (United States)

    Frew, Andrew W.

    1997-01-01

    Integrating literature and mathematics can be meaningful using David Macaulay's "Pyramid." This article provides an annotated bibliography of picture books, fiction, folk tales, nonfiction, videotapes, audio books, and CD-ROMs for grades 1-12 to support a unit on Egypt. Describes related math activities; and highlights a catalog of…

  16. David Robichaud | NREL

    Science.gov (United States)

    . David leads the NREL arm of the Consortium for Computational Physics and Chemistry, which utilizes -advantaged fuels Affiliated Research Programs Consortium for Computational Physics and Chemistry (CCPC) Co -Optimization of Fuels & Engines Education Ph.D., Chemistry, California Institute of Technology, 2007 B.S

  17. David Warner (1934 - 2003)

    CERN Multimedia

    2004-01-01

    It is with great sadness that we learned that our friend and former colleague, David Warner, passed away on Christmas Eve. The funeral was held the following Monday. David was a "linac man". His career centred around linacs, but with a multitude of different subjects. He began at CERN by building the 3 MeV linac in the extension of the South Hall. He did pioneering work on this machine, which paved the way towards the design of the Alvarez cavities for the CERN Linac 2, for which he was responsible. After this challenge was successfully finished, David was the first member of the small but growing team, that was in charge of building the LEP Injector Linacs (LIL). After having been recognised as a proton linac expert, he quickly converted to electron linacs where he soon became the respected key expert for the design, parameters and ultimate performance of LIL. His predilection for precise and detailed documentation, and his vision that the know-how acquired with LIL should be preserved a...

  18. David Livingstone's uvulectomy.

    Science.gov (United States)

    Larner, A J

    2006-05-01

    In April 1852 in Cape Town, South Africa, Dr David Livingstone, then 39 years of age and yet to commence the explorations of Africa which would bring him to public attention, underwent the surgical procedure of uvulectomy. This article reviews the history of Livingstone's uvulectomy and its indications and outcome, as documented by his own writings. The practice of uvulectomy in indigenous African societies and some contemporary ideas about uvulectomy are also considered in order to try to ascertain why Livingstone elected to undergo this procedure.

  19. Pora prodavat znanija / David Tisch

    Index Scriptorium Estoniae

    Tisch, David

    2006-01-01

    California Ülikooli (Berkeley) professor David Tisch teadmistepõhistest väärtustest ja nende mõjust konkurentsivõimele, konkurentsist innovatsiooniturul, Silicon Valley edu põhjustest, väikeste ja keskmiste ettevõtete osast innovatsioonis. Lisa: David Tisch

  20. Laurance David Hall.

    Science.gov (United States)

    Coxon, Bruce

    2011-01-01

    An account is given of the life, scientific contributions, and passing of Laurance David Hall (1938-2009), including his early history and education at the University of Bristol, UK, and the synthesis and NMR spectroscopy of carbohydrates and other natural products during ∼20 years of research and teaching at the University of British Columbia in Vancouver, Canada. Lists of graduate students, post-doctoral fellows, and sabbatical visitors are provided for this period. Following a generous endowment by Dr. Herchel Smith, Professor Hall built a new Department of Medicinal Chemistry at Cambridge University, UK, and greatly expanded his researches into the technology and applications of magnetic resonance imaging (MRI) and zero quantum NMR. MRI technology was applied both to medical problems such as the characterization of cartilage degeneration in knee joints, the measurement of ventricular function, lipid localization in animal models of atherosclerosis, paramagnetic metal complexes of polysaccharides as contrast agents, and studies of many other anatomical features, but also to several aspects of materials analysis, including food analyses, process control, and the elucidation of such physical phenomena as the flow of liquids through porous media, defects in concrete, and the visualization of fungal damage to wood. Professor Hall's many publications, patents, lectures, and honors and awards are described, and also his successful effort to keep the Asilomar facility in Pacific Grove, California as the alternating venue for the annual Experimental NMR Conference. Two memorial services for Professor Hall are remembered. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. David Asbury (1950-2015)

    CERN Multimedia

    2015-01-01

    It was with great sadness that we learned that David Asbury passed away in his sleep last week.   David joined CERN in 1984 after having worked for some years at RAL in the UK. He was a skilled programmer and systems engineer, and much appreciated by both users and colleagues at CERN. His contributions to IT services include the IBM mainframe workhorse CERN VM, the backup tape service and in recent years the version control services, until his well-deserved retirement at the end of March this year. We will all remember David for his friendly and helpful manners, and as a warm person who was always caring for others, particularly newcomers. David was also a passionate musician and active tennis player. He will be greatly missed by his colleagues. A memorial service took place at 11 a.m. on Monday, 14 December 2015 at the Auditoire Calvin next to the Cathedral in Geneva. His colleagues and friends

  2. Interview of David Elliston Allen

    OpenAIRE

    Allen, David

    2009-01-01

    Interviewed on 12 April 1983 by Jack Goody and Alan Macfarlane and filmed and edited by Sarah Harrison. Made on old and low quality equipment. An interview of the historian and naturalist David Elliston Allen

  3. David's Understanding of Functions and Periodicity

    Science.gov (United States)

    Gerson, Hope

    2008-01-01

    This is a study of David, a senior enrolled in a high school precalculus course. David's understandings of functions and periodicity was explored, through clinical interviews and contextualized through classroom observations. Although David's precalculus class was traditional his understanding of periodic functions was unconventional David engaged…

  4. Henry David Thoreau's Spiritual World

    Institute of Scientific and Technical Information of China (English)

    马云

    2013-01-01

    Henry David Thoreau was wholeheartedly in love with nature and he devoted almost all his life time to observation, appreciation and study of nature. Thus he formed a deep understanding of nature. In 1845, Thoreau began a two-year and two-month residence at Walden Pond. His life was lonely but full of fragrance. He wanted to live meaningfully, confront the essential facts of life and live a simple life. Based on the review of the literature related to this topic, this paper aims to study Henry David Thoreau’s spiritual world, especially reflected in his famous book-Walden.

  5. A tribute to David Triggle.

    Science.gov (United States)

    Moos, Walter H

    2015-11-15

    "A gentleman and a scholar" is how many would characterize David Triggle. His insightful, thoughtful approaches to professional pursuits, both personal research and collaborative relationships, stand out by any measure. He has shaped students, colleagues, and whole fields, calcium ion channels and ligands being most representative of the latter. In recent years, he has expanded his contributions to important commentaries on politics and social challenges in the sciences. David is the rare intellect able to do all this and more, as outlined herein. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. A Reply from David Elkind.

    Science.gov (United States)

    Elkind, David

    1989-01-01

    Replying to Robert H. Anderson's article in the same "Principal" issue, David Elkind defends his article against classroom rotation. Elkind strongly favors multiage grouping and team teaching, but views the real issue as departmentalization and rotation versus self-contained classrooms. Although multiage grouping and team teaching are…

  7. King, Prof. Sir David Anthony

    Indian Academy of Sciences (India)

    Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

  8. David Owen Williams (1944 - 2006)

    CERN Multimedia

    2006-01-01

    Many people, not only at CERN but also throughout the world, were saddened to learn that their friend and colleague David Williams had passed away in the early hours of Tuesday 24 October. His death came after a year of fighting cancer with all of his usual determination and optimism. Even days before the end he was still welcoming to visitors, and was alert and interested in all their news. Born in 1944, David came to CERN from the University of Cambridge in 1966, with a degree in Physics and Computer Science. Joining what at the time was called the Documents and Data (DD) Division, in the earlier part his career he worked first on software for analysis of bubble chamber photographs, subsequently leading the group that supported experiments with 'hybrids' of bubble chambers and electronic detectors and then the group supporting online computing in experiments. He thus witnessed all of the enormous changes that took place in particle physics as the era of bubble chambers came to an end and the availability ...

  9. Distributed Access View Integrated Database (DAVID) system

    Science.gov (United States)

    Jacobs, Barry E.

    1991-01-01

    The Distributed Access View Integrated Database (DAVID) System, which was adopted by the Astrophysics Division for their Astrophysics Data System, is a solution to the system heterogeneity problem. The heterogeneous components of the Astrophysics problem is outlined. The Library and Library Consortium levels of the DAVID approach are described. The 'books' and 'kits' level is discussed. The Universal Object Typer Management System level is described. The relation of the DAVID project with the Small Business Innovative Research (SBIR) program is explained.

  10. [Exhibition review of] David Bowie is

    DEFF Research Database (Denmark)

    Langkjær, Michael Alexander

    2014-01-01

    Anmeldelse af en udstilling d. 23. marts - 28. juli 2013 om rockmusikeren David Bowie på Victoria and Albert Museet, London.......Anmeldelse af en udstilling d. 23. marts - 28. juli 2013 om rockmusikeren David Bowie på Victoria and Albert Museet, London....

  11. Dr. David Syz, State Secretary for Economic Affairs, Switzerland

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Photo 01: Dr. David Syz (left) with Professor Roger Cashmore, Research Director for Collider Programmes.Photo 02: Dr. David Syz signing the VIP visitors' book, with Prof. Roger Cashmore.Photo 03: Dr. David Syz signing the VIP visitors' book.Photo 04: Handshake between Dr. David Syz (left) and Prof. Roger Cashmore.

  12. Obituary: David Stanley Evans, 1916-2004

    Science.gov (United States)

    Bash, Frank N.

    2005-12-01

    David Stanley Evans died on 14 November 2004 in Austin, Texas. He was a noted observational astronomer whose career was divided between South Africa and Texas. He also used the extensive historical collections at the University of Texas to write several books on the history of astronomy. He was born in Cardiff, Wales on 28 January 1916. David received his BA degree in mathematics in 1937 from Kings College, Cambridge. He became a PhD student at Cambridge Observatory in 1937, and was one of Sir Arthur Eddington's last surviving students. He received his PhD degree in 1941 with a dissertation entitled, "The Formation of the Balmer Series of Hydrogen in Stellar Atmospheres." He was a conscientious objector to war and, thus, spent the war years at Oxford working with physicist Kurt Mendelssohn on medical problems, involving cadavers, relating to the war. During these years, David was scientific editor of "Discovery", and he was editor of "The Observatory". David left England in 1946 in order to take up the position of Second Assistant at the Radcliffe Observatory, Pretoria, South Africa. He and H. Knox Shaw were the entire staff after R. O. Redman left, and they aluminized and installed the mirrors in the 74-inch telescope. His notable scientific contribution was to use lunar occultations to measure stellar angular diameters during the 1950s. He succeeded in determining the angular diameter of Antares and determined that Arcturus was not circular but had an elliptical shape. The elliptical shape was later shown to be an instrumental artifact, but the utility of using lunar occultations to measure stellar diameters and stellar multiplicity was conclusively demonstrated. T. Gold presented David's paper on lunar occultation angular diameters at the January 1953 meeting of the Royal Astronomical Society. For the rest of his life, David resented Gold's remarks, because he felt that he had been ridiculed. By 1953, David Evans was Chief Assistant at the Royal Observatory

  13. A Summary Score for the Framingham Heart Study Neuropsychological Battery.

    Science.gov (United States)

    Downer, Brian; Fardo, David W; Schmitt, Frederick A

    2015-10-01

    To calculate three summary scores of the Framingham Heart Study neuropsychological battery and determine which score best differentiates between subjects classified as having normal cognition, test-based impaired learning and memory, test-based multidomain impairment, and dementia. The final sample included 2,503 participants. Three summary scores were assessed: (a) composite score that provided equal weight to each subtest, (b) composite score that provided equal weight to each cognitive domain assessed by the neuropsychological battery, and (c) abbreviated score comprised of subtests for learning and memory. Receiver operating characteristic analysis was used to determine which summary score best differentiated between the four cognitive states. The summary score that provided equal weight to each subtest best differentiated between the four cognitive states. A summary score that provides equal weight to each subtest is an efficient way to utilize all of the cognitive data collected by a neuropsychological battery. © The Author(s) 2015.

  14. A Revised Framingham Stroke Risk Profile to Reflect Temporal Trends

    Science.gov (United States)

    Dufouil, Carole; Beiser, Alexa; McLure, Leslie A.; Wolf, Philip A.; Tzourio, Christophe; Howard, Virginia J; Westwood, Andrew J.; Himali, Jayandra J.; Sullivan, Lisa; Aparicio, Hugo J.; Kelly-Hayes, Margaret; Ritchie, Karen; Kase, Carlos S.; Pikula, Aleksandra; Romero, Jose R.; D’Agostino, Ralph B.; Samieri, Cécilia; Vasan, Ramachandran S.; Chêne, Genevieve; Howard, George; Seshadri, Sudha

    2017-01-01

    Background Age-adjusted stroke incidence has decreased over the past 50 years, likely due to changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the Framingham Heart Study (FHS) and other cohorts. We compared the accuracy of the standard (Old), and of a revised (New) version of the FSRP in predicting the risk of all-stroke and ischemic stroke, and validated this new FSRP in two external cohorts, the 3 Cities (3C) and REGARDS studies. Methods We computed the old FSRP as originally described, and a new model that used the most recent epoch-specific risk factors' prevalence and hazard-ratios for persons ≥ 55 years and for the subsample ≥ 65 years (to match the age range in REGARDS and 3C studies respectively), and compared the efficacy of these models in predicting 5- and 10-year stroke risks. Results The new FSRP was a better predictor of current stroke risks in all three samples than the old FSRP (Calibration chi-squares of new/old FSRP: in men 64.0/12.1, 59.4/30.6 and 20.7/12.5; in women 42.5/4.1, 115.4/90.3 and 9.8/6.5 in FHS, REGARDS and 3C, respectively). In the REGARDS, the new FSRP was a better predictor among whites compared to blacks. Conclusions A more contemporaneous, new FSRP better predicts current risks in 3 large community samples and could serve as the basis for examining geographic and racial differences in stroke risk and the incremental diagnostic utility of novel stroke risk factors. PMID:28159800

  15. Revised Framingham Stroke Risk Profile to Reflect Temporal Trends.

    Science.gov (United States)

    Dufouil, Carole; Beiser, Alexa; McLure, Leslie A; Wolf, Philip A; Tzourio, Christophe; Howard, Virginia J; Westwood, Andrew J; Himali, Jayandra J; Sullivan, Lisa; Aparicio, Hugo J; Kelly-Hayes, Margaret; Ritchie, Karen; Kase, Carlos S; Pikula, Aleksandra; Romero, Jose R; D'Agostino, Ralph B; Samieri, Cécilia; Vasan, Ramachandran S; Chêne, Genevieve; Howard, George; Seshadri, Sudha

    2017-03-21

    Age-adjusted stroke incidence has decreased over the past 50 years, likely as a result of changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the FHS (Framingham Heart Study) and other cohorts. We compared the accuracy of the standard (old) and of a revised (new) version of the FSRP in predicting the risk of all-stroke and ischemic stroke and validated this new FSRP in 2 external cohorts, the 3C (3 Cities) and REGARDS (Reasons for Geographic and Racial Differences in Stroke) studies. We computed the old FSRP as originally described and a new model that used the most recent epoch-specific risk factor prevalence and hazard ratios for individuals ≥55 years of age and for the subsample ≥65 years of age (to match the age range in REGARDS and 3C studies, respectively) and compared the efficacy of these models in predicting 5- and 10-year stroke risks. The new FSRP was a better predictor of current stroke risks in all 3 samples than the old FSRP (calibration χ 2 of new/old FSRP: in men: 64.0/12.1, 59.4/30.6, and 20.7/12.5; in women: 42.5/4.1, 115.4/90.3, and 9.8/6.5 in FHS, REGARDS, and 3C, respectively). In the REGARDS, the new FSRP was a better predictor among whites compared with blacks. A more contemporaneous, new FSRP better predicts current risks in 3 large community samples and could serve as the basis for examining geographic and racial differences in stroke risk and the incremental diagnostic utility of novel stroke risk factors. © 2017 American Heart Association, Inc.

  16. Systemic inflammation and COPD: the Framingham Heart Study.

    Science.gov (United States)

    Walter, Robert E; Wilk, Jemma B; Larson, Martin G; Vasan, Ramachandran S; Keaney, John F; Lipinska, Izabella; O'Connor, George T; Benjamin, Emelia J

    2008-01-01

    The current paradigm for the pathogenesis of COPD includes an ultimately maladaptive local inflammatory response to environmental stimuli. We examined the hypothesis that systemic inflammatory biomarkers are associated with impaired lung function, particularly among those with extensive cigarette smoking. Using data from the Framingham Heart Study, we examined cross-sectional associations of systemic inflammatory biomarkers (CD40 ligand [CD40L], intercellular adhesion molecule [ICAM]-1, interleukin [IL]-6, monocyte chemoattractant protein-1, P-selectin, and myeloperoxidase, in addition to C-reactive protein) to impaired lung function. IL-6 was consistently associated with impaired lung function; a 1-SD higher concentration of IL-6 was associated with a 41-mL lower FEV(1) (95% confidence interval [CI], - 61 to - 20) and a borderline 15% higher odds of COPD (odds ratio, 1.15; 95% CI, 0.99 to 1.34). Additionally, P-selectin was associated with lower FEV(1) levels; after adjusting for the other biomarkers, a 1-SD higher concentration of P-selectin predicted an FEV(1) that was on average 19 mL lower (95% CI, - 37 to 0). Including the biomarkers individually as sole exposures in the models generally strengthened the impaired lung function/biomarker association; the relations of ICAM-1 to FEV(1), and ICAM and CD40L to COPD became significant. The observed associations did not vary significantly with smoking history, except that the association between CD40L and COPD appeared greater in individuals with more extensive smoking histories. Among participants in the Framingham Heart Study, systemic inflammation was associated with lower levels of pulmonary function. Further research into the role of systemic inflammation in the development of pulmonary dysfunction is merited.

  17. David Schwartz | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    David joined IDRC in 2002 and has held the director post since 2010. His previous experience includes working in the financial sector at CIBC World Markets and field work on commercializing microfinance in Bolivia. He holds a master's in environmental studies from York University and a BA in political science from ...

  18. Where to Sit? Type of Sitting Matters for the Framingham Cardiovascular Risk Score

    Directory of Open Access Journals (Sweden)

    Katja Borodulin

    2016-08-01

    Full Text Available Background: Current evidence on associations of type-specific sedentary behavior with cardiovascular disease (CVD is limited to mainly screen-time sedentary behavior (SB. We aimed to study the associations of type-specific and total time spent sitting with the Framingham 10-year cardiovascular disease risk score (Framingham score in Finnish adults. Methods: Data comprise the National FINRISK 2007 and 2012 health examination surveys with 10,185 participants aged 25-74 years, apparently free of CVD. Participants reported average daily time spent sitting in different locations: work-related sitting, at home in front of television (TV, at home in front of computer, in a vehicle, and elsewhere. Total SB time was calculated from these context-specific self-reports. Accelerometer-based sedentary time was assessed in 988 FINRISK 2012 participants. Framingham score was calculated using information on blood pressure and its medication, cholesterol levels, age, diabetes status, and smoking. Analyses were adjusted for age, study year, education, employment status, leisure time physical activity, and body mass index. Results: Out of several type-specific sitting behaviors, only TV sitting showed systematic associations with the Framingham score in both genders. The lowest Framingham risk was found for TV sitting from 6 minutes to less than 1 hour daily. Of other types of sitting, computer sitting was inversely associated with the Framingham risk in men only. Total self-reported sitting time did not show significant associations with the Framingham score, but instead higher objectively assessed sedentary time showed higher Framingham risk in men. Conclusions: TV sitting showed most systematic associations with CVD risk score. This suggests that of all types of SB, reducing TV sitting should be targeted for reducing CVD risk.

  19. H. David Politzer, Asymptotic Freedom, and Strong Interaction

    Science.gov (United States)

    dropdown arrow Site Map A-Z Index Menu Synopsis H. David Politzer, Asymptotic Freedom, and Strong Interaction Resources with Additional Information H. David Politzer Photo Credit: California Institute of Technology H. David Politzer has won the 2004 Nobel Prize in Physics 'for the discovery of asymptotic freedom

  20. Metabolic syndrome and Framingham risk score in obese young adults

    Directory of Open Access Journals (Sweden)

    Felix F. Widjaja

    2013-05-01

    Full Text Available Background: The increase number of the metabolic syndrome (MetS among young adults was mostly caused by obesity. MetS increases the risk of coronary heart disease (CHD which can be estimated by Framingham risk score (FRS. The study was aimed to know the prevalence of MetS and FRS in obese young adults and to associate them with the components of MetS. Methods: A total of 70 male and female students aged 18 to 25 years with BMI ≥ 25 kg/m2 in Faculty of Medicine Universitas Indonesia were selected consecutively. The blood samples used to test fasting blood glucose, total cholesterol, high-density lipoprotein, and triglyceride were examined in Department of Clinical Pathology, Cipto Mangunkusumo Hospital after fasting for 14 to 16 hours. International Diabetes Federation (IDF definition was used to diagnose MetS. Univariate and bivariate analysis were done. Results: The prevalence of MetS based on IDF definition was 18.6% among obese young adults. The most associated MetS components was hypertriglyceridemia (OR 12.13; 95% CI 2.92-50.46; p = 0.001, followed with high blood pressure (OR 9.33; 95% CI 2.26-38.56; p = 0.001, low-HDL (OR 8.33; 95% CI 2.17-32.05; p = 0.003, and impaired fasting glucose (p = 0.03. Four subjects had FRS ≥ 1% and 66 subjects had risk < 1%. Increased FRS was not associated with MetS (p = 0.154. There was no component of MetS associated with increased FRS. Conclusion: Prevalence of MetS in obese young adults was similar with obese children and adolescents. Although no association of MetS and FRS was found, they are significant predictors for CHD which should not be used separately. (Med J Indones. 2013;22:100-6Keywords: Abdominal obesity, Framingham risk score, metabolic syndrome, young adults

  1. David Miller on Immigration Policy and Nationality

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2007-01-01

    David Miller's recent statement of the case for restrictive immigration policies can plausibly be construed as an application of a ‘liberal nationalist' position. The paper first addresses Miller's critique of distributive justice arguments for open borders, which relies on nationality as determi......David Miller's recent statement of the case for restrictive immigration policies can plausibly be construed as an application of a ‘liberal nationalist' position. The paper first addresses Miller's critique of distributive justice arguments for open borders, which relies on nationality...... as determinative of the scope of distributive justice and as giving rise to national collective responsibility. Three interpretations of his main positive reason for restricting immigration, which concerns the importance of a shared public culture, are then discussed: culture as having valuable social functions...... in relation to immigration policy....

  2. Transient global amnesia and neurological events: the Framingham Heart Study

    Directory of Open Access Journals (Sweden)

    Jose Rafael Romero

    2013-05-01

    Full Text Available Background/ objective: Transient global amnesia (TGA is a temporary amnestic syndrome characterized by lack of other focal neurological deficits. Cerebrovascular disease, migraine and seizures have been suggested as underlying mechanisms. TGA may be a risk factor for cerebrovascular or other neurological events. We studied the relation of TGA, vascular risk factors, brain magnetic resonance imaging (MRI indices of subclinical ischemia and neurological events in a community-based sample. Design/setting: A total of 12 TGA cases were ascertained using standard criteria by experienced neurologists, and matched to 41 stroke- and seizure-free controls. Vascular risk factors, brain MRI findings, and subsequent cerebrovascular or seizure events were compared in cases and controls. Participants: Framingham Heart Study (FHS original and offspring cohort participants were included.Results: No significant differences between the groups were observed in the prevalence of vascular risk factors, or brain MRI measures. Few incident stroke/transient ischemic attacks (TIA (1 event among the cases and 4 in controls or subsequent seizures occurred in either group. Head CT during the acute event (n=11 and brain MRI (n=7 were negative for acute abnormalities. Electroencephalograms (EEG (n=5 were negative for epileptiform activity. Extracranial vascular studies were negative for significant stenosis in all cases.Conclusions: In our community-based study TGA was not related to traditional vascular risk factors, or cerebrovascular disease. However, our study is limited by small sample size and power, and larger studies are required to exclude an association.

  3. Clinical associations of total kidney volume: the Framingham Heart Study.

    Science.gov (United States)

    Roseman, Daniel A; Hwang, Shih-Jen; Oyama-Manabe, Noriko; Chuang, Michael L; O'Donnell, Christopher J; Manning, Warren J; Fox, Caroline S

    2017-08-01

    Total kidney volume (TKV) is an imaging biomarker that may have diagnostic and prognostic utility. The relationships between kidney volume, renal function and cardiovascular disease (CVD) have not been characterized in a large community-dwelling population. This information is needed to advance the clinical application of TKV. We measured TKV in 1852 Framingham Heart Study participants (mean age 64.1 ± 9.2 years, 53% women) using magnetic resonance imaging. A healthy sample was used to define reference values. The associations between TKV, renal function and CVD risk factors were determined using multivariable logistic regression analysis. Overall, mean TKV was 278 ± 54 cm3 for women and 365 ± 66 cm3 for men. Risk factors for high TKV (>90% healthy referent size) were body surface area (BSA), diabetes, smoking and albuminuria, while age, female and estimated glomerular filtration rate (eGFR) kidney damage including albuminuria and eGFR <60 mL/min/1.73 m2, while high TKV is associated with diabetes and decreased odds of eGFR <60 mL/min/1.73 m2. Prospective studies are needed to characterize the natural progression and clinical consequences of TKV. Published by Oxford University Press on behalf of ERA-EDTA 2016. This work is written by US Government employees and is in the public domain in the US.

  4. David Galula: His Life and Intellectual Context

    Science.gov (United States)

    2010-08-01

    publication of a novel, and his untimely death . 1 DAVID GALULA: HIS LIFE AND INTELLECTUAL CONTEXT INTRODUCTION It is a safe bet that if the United States had...and translated for the first time into French, nearly 40 years after his death —he remains almost unknown to the nation whose uniform he wore for most...lycées. 23 Galula was a bad student who preferred to play hooky, going horseback riding or swimming. (Galula would be a passionate horseman

  5. David Ferrier: brain drawings and brain maps.

    Science.gov (United States)

    Lazar, J Wayne

    2013-01-01

    This chapter has two emphases, one is about the men who influenced the visual representations that David Ferrier (1843-1928) used to illustrate his work on localization of brain functions during the years 1873-1875, namely, Alexander Ecker, John C. Galton, and Ernest Waterlow, and the other is about the nature of medical representations and of Ferrier's illustrations in particular. Medical illustrations are characterized either as pictures, line drawings, or brain maps. Ferrier's illustrations will be shown to be increasingly sophisticated brain maps that contrast with early nineteenth-century standards of medical illustrations, as exemplified by John Bell (1763-1829). © 2013 Elsevier B.V. All rights reserved.

  6. Social networks and inflammatory markers in the Framingham Heart Study.

    Science.gov (United States)

    Loucks, Eric B; Sullivan, Lisa M; D'Agostino, Ralph B; Larson, Martin G; Berkman, Lisa F; Benjamin, Emelia J

    2006-11-01

    Lack of social integration predicts coronary heart disease mortality in prospective studies; however, the biological pathways that may be responsible are poorly understood. The specific aims of this study were to examine whether social networks are associated with serum concentrations of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1). Participants in the Framingham Study attending examinations from 1998 to 2001 (n=3267) were eligible for inclusion in the study. Social networks were assessed using the Berkman-Syme Social Network Index (SNI). Concentrations of IL-6, CRP, sICAM-1 and MCP-1 were measured in fasting serum samples. Multivariable linear regression analyses were used to assess the association of social networks with inflammatory markers adjusting for potential confounders including age, smoking, blood pressure, total:HDL cholesterol ratio, body mass index, lipid-lowering and antihypertensive medication, diabetes, cardiovascular disease, depression and socioeconomic status. Results found that the SNI was significantly inversely associated with IL-6 in men (p=0.03) after adjusting for potential confounders. In age-adjusted analyses, social networks also were significantly inversely associated with IL-6 for women (p=0.03) and were marginally to modestly associated with CRP and sICAM-1 for men (p=0.08 and 0.02, respectively), but these associations were not significant in the multivariate analyses. In conclusion, social networks were found to be inversely associated with interleukin-6 levels in men. The possibility that inflammatory markers may be potential mediators between social integration and coronary heart disease merits further investigation.

  7. High Framingham risk score decreases quality of life in adults

    Directory of Open Access Journals (Sweden)

    Christian Yosaputra

    2010-04-01

    Full Text Available Cardiovascular disease (CVD risk factors, such as diabetes, hypertension, hypercholesterolemia, smoking, and obesity tend to occur together in the general population. Increasing prevalence of multiple CVD risk factors has been related to increased risk of death from coronary heart disease and stroke. Studies have suggested that people with several risk factors of CVD may have impaired health-related quality of life. The objective of this study was to assess the association of CVD risk factors with quality of life (QOL among adults aged 40 to 65 years. A cross-sectional study was conducted involving 220 subjects 40 - 65 years of age at a health center. The CVD risk factors were assessed using the Framingham risk score that is the standard instrument for assessment of the risk of a first cardiac event. The risk factors assessed were age, smoking, blood pressure, total cholesterol and high density lipoprotein cholesterol concentrations. QOL was assessed by means of the WHOQOL-BREF instrument that had been prevalidated. The results of the study showed that 28.2% of subjects were smokers, 56.4% had stage 1 hypertension, 42.8% high total cholesterol and 13.6% low HDL cholesterol. The high risk group amounted to 45.5% and 42.3% constitued an intermediate risk group. High CVD risk scores were significantly associated with a low QOL for all domains (physical, psychological, social and environment (p=0.000. Preventing or reducing the multiple CVD risk factors to improve QOL is necessary among adults.

  8. Modified Framingham Risk Factor Score for Systemic Lupus Erythematosus.

    Science.gov (United States)

    Urowitz, Murray B; Ibañez, Dominique; Su, Jiandong; Gladman, Dafna D

    2016-05-01

    The traditional Framingham Risk Factor Score (FRS) underestimates the risk for coronary artery disease (CAD) in patients with systemic lupus erythematosus (SLE). We aimed to determine whether an adjustment to the FRS would more accurately reflect the higher prevalence of CAD among patients with SLE. Patients with SLE without a previous history of CAD or diabetes followed regularly at the University of Toronto Lupus Clinic were included. A modified FRS (mFRS) was calculated by multiplying the items by 1.5, 2, 3, or 4. In the first part of the study, using one-third of all eligible patients, we evaluated the sensitivity and specificity of the FRS and the different multipliers for the mFRS. In the second part of the study, using the remaining 2/3 of the eligible patients, we compared the predictive ability of the FRS to the mFRS. In the third part of the study, we assessed the prediction for CAD in a time-dependent analysis of the FRS and mFRS. There were 905 women (89.3%) with a total of 95 CAD events included. In part 1, we determined that a multiplier of 2 provided the best combination of sensitivity and specificity. In part 2, 2.4% of the patients were classified as moderate/high risk based on the classic FRS and 17.3% using the 2FRS (the FRS with a multiplier of 2). In part 3, a time-dependent covariate analysis for the prediction of the first CAD event revealed an HR of 3.22 (p = 0.07) for the classic FRS and 4.37 (p mFRS in which each item is multiplied by 2 more accurately predicts CAD in patients with SLE.

  9. Social outcomes of learning - Response to paper by David Campwell

    DEFF Research Database (Denmark)

    Andersen, John

    Expert kommentar til rapportudkast fra David Cambell (tidligere forskningsassistent for Robert Putman) i OECD projektet SOL (Social Outcomes of Learning). Publiceres senere som Discussionpaper af OECD...

  10. Subject in Tractatus according to David Pears

    Directory of Open Access Journals (Sweden)

    M Hoseinzadeh Yazdi

    2013-02-01

    Full Text Available Subjectivism is viewed as one of the most fundamental underpinnings of modern philosophy. In modern philosophy, subject takes up a new position in human knowledge. The formation of the concept of subject is a decisive turn with which the modern philosophy starts. Considering the centrality of subjectivism in modern philosophy, this article attempts to explain subject in Tractatus according to David Pears. A review of Wittgenstein’s earlier teachings reveals that he considers a fundamental limitation for language. The subject serves as a point of view from which the language can be understood. The subject is the presupposition of understanding. Another way of putting this would be to say that any experience is understood from a point of view which is not represented in that experience. Regarding this, it seems that earlier Wittgenstein is somehow subjectivist. This specific form of subjectivism is different from Kantian subjectivism.

  11. Guerra e Paz, por David Grossman

    Directory of Open Access Journals (Sweden)

    Luis Sérgio Krausz

    2010-03-01

    Full Text Available Na Bíblia Hebraica, a guerra é um assunto diretamente vinculado à esfera do sagrado. A proteção de Deus ao povo de Israel em suas batalhas é, assim, um dos fundamentos da teologia bíblica. No romance, A mulher foge, de David Grossman, como em Homero, a realidade da guerra contrapõe-­se à realidade das pessoas comuns e, assim, separa, em um vasto abismo, as experiências deste e daquele lado. Ao contrário do que acontece na Bíblia, e também na Ilíada, não há, nas guerras do romance, qualquer tipo de crença divina, seja ela de molde pagão, seja ela de caráter retributivo, conforme a teologia bíblica.

  12. David Lukens Reasoner (1941-1992)

    Science.gov (United States)

    Chappell, Rick

    David Lukens Reasoner, former head of NASA's Ionospheric Physics branch, died on April 21, 1992. Reasoner was born July 1, 1941. He worked tirelessly to expand NASA's Space Physics Division, bringing his deep experience and personal expertise to bear on the challenges of growth.During the magical period of the late 1950s and early 1960s when America turned its eyes toward space and the Moon, David Lukens Reasoner journeyed north from the nearby Texas town of Dickinson to Rice University with an idea of getting involved in exploring the frontiers of space. He pursued a course of study in electrical engineering and received a bachelor's degree in 1963 and a master's degree in 1964. In the early 1960s, the Space Science Department at Rice was formed, and President John Kennedy visited to say that America chose to go to space not because it is easy but because it is hard and because it would require the very best talents of our nation to succeed. Dave Reasoner was one of those talented people. His excellence in electrical engineering and physics, combined with his natural abilities in the laboratory, suited him ideally for building the machines of space. As a student, he built sounding rocket payloads and multiple instruments for satellites and experiment packages that were placed on the Moon by the Apollo astronauts. He completed his doctoral degree in space science in 1968. It was in these early thrilling days of space exploration that I first met Dave, beginning a friendship and collegial relationship that was to last 27 years.

  13. David L. Rosenhan (1929-2012).

    Science.gov (United States)

    Ross, Lee; Kavanagh, David

    2013-09-01

    Presents an obituary for David L. Rosenhan (1929-2012). A distinguished psychologist and professor emeritus at Stanford University, Rosenhan died February 6, 2012, at the age of 82, after a long illness. Born in Jersey City, New Jersey, on November 22, 1929, he received a bachelor's degree in mathematics (1951) from Yeshiva College and a master's degree in economics (1953) and a doctorate in psychology (1958) from Columbia University. A professor of law and of psychology at Stanford University from 1971 until his retirement in 1998, Rosenhan was a pioneer in applying psychological methods to the practice of law, including the examination of expert witnesses, jury selection, and jury deliberation. A former president of the American Psychology-Law Society and of the American Board of Forensic Psychology, Rosenhan was a fellow of the American Association for the Advancement of Science, of the American Psychological Association, and of the American Psychological Society. Before joining the Stanford Law School faculty, he was a member of the faculties of Swarthmore College, Princeton University, Haverford College, and the University of Pennsylvania. He also served as a research psychologist at the Educational Testing Service. As generations of Stanford students can attest, David Rosenhan was a spellbinding lecturer who managed to convey the sense that he was speaking to each individual, no matter how large the group. To his graduate students, he was consistently encouraging and optimistic, always ready to share a joke or story, and gently encouraging of their creativity and progressive independence as researchers. The lessons he cared most about offering, in the classroom as in his research, were about human dignity and the need to confront abuse of power and human frailties. © 2013 APA, all rights reserved.

  14. State of the Art Coronary Heart Disease Risk Estimation based on the Framingham Heart Study

    Czech Academy of Sciences Publication Activity Database

    Reissigová, Jindra; Tomečková, Marie

    2005-01-01

    Roč. 13, č. 4 (2005), s. 180-186 ISSN 0022-1732 Institutional research plan: CEZ:AV0Z10300504 Keywords : Framingham heart study * coronary heart disease * risk validation study * calibration * discrimination Subject RIV: BA - General Mathematics

  15. The Framingham Risk Function Underestimated Absolute Coronary Heart Disease Risk in Czech Men

    Czech Academy of Sciences Publication Activity Database

    Reissigová, Jindra; Zvárová, Jana

    2007-01-01

    Roč. 46, č. 1 (2007), s. 43-49 ISSN 0026-1270 Institutional research plan: CEZ:AV0Z10300504 Keywords : external validation * Framingham risk function * coronary heart disease Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 1.451, year: 2007

  16. Venemaa - lähedane ja kauge / David Vseviov

    Index Scriptorium Estoniae

    Vseviov, David, 1949-

    2007-01-01

    Rmt.: Sergejev, Vladimir ; Vseviov, David. Venemaa - lähedane ja kauge : aegade algusest kuni Vassili III-ni. Tallinn : Valgus, 2002 ; Sergejev, Vladimir ; Vseviov, David. Venemaa - lähedane ja kauge : vürstiriigist tsaaririigiks. Ivan IV. Tallinn : Valgus, 2007.

  17. 75 FR 10244 - Ellsworth, David C.; Notice of Filing

    Science.gov (United States)

    2010-03-05

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-3716-001] Ellsworth, David C.; Notice of Filing February 25, 2010. Take notice that on February 12, 2010, David C. Ellsworth filed an informational report for authority to hold interlocking positions, pursuant to section 45.9 of...

  18. Escore de Framingham em motoristas de transportes coletivos urbanos de Teresina, Piauí Framingham score for public transportation drivers in the dity of Teresina, Piauí

    Directory of Open Access Journals (Sweden)

    Maurício Batista Paes Landim

    2006-09-01

    Full Text Available OBJETIVO: Estimar o risco absoluto de contração de doença arterial coronariana, nos próximos 10 anos, em motoristas de transportes coletivos urbanos de Teresina, Piauí, segundo o escore de risco de Framingham. MÉTODOS: Foi realizado um estudo observacional, descritivo, transversal, aplicando-se o escore de Framingham, em 107 motoristas de transportes coletivos urbanos de Teresina, Piauí, para avaliação do grau de risco e sua associação com as variáveis previstas no mesmo, que foram: idade, colesterol total, colesterol HDL, pressão arterial sistólica, pressão arterial diastólica, presença de diabete melito e tabagismo. O teste de significância usado foi o c². Utilizou-se a razão de prevalência como medida de associação. RESULTADOS: O risco médio foi de 5%, com a maior parte situando-se na categoria de baixo risco (85,05%. As médias obtidas foram: 42 anos para a idade, colesterol total 200 mg%, colesterol HDL 49 mg%, pressão arterial sistólica 130 mmHg e pressão arterial diastólica 85 mmHg. As associações diabete melito, tabagismo e colesterol HDL, com o risco, não foram estatisticamente significantes, diferente do ocorrido com as outras variáveis, que tiveram grande influência no risco obtido. CONCLUSÃO: O risco absoluto médio estimado para os próximos 10 anos de doença arterial coronariana, em motoristas de transportes coletivos urbanos de Teresina, calculado pelo escore de Framingham, apresentou-se baixo. Uma parte considerável dos participantes da pesquisa (85,05% situou-se na categoria de baixo risco, ou seja, igual ou inferior a 10%.OBJECTIVE: To estimate the absolute risk of the public transportation drivers in the city of Teresina, Piauí, to develop coronary heart disease over the course of ten years based on the Framingham risk score. METHODS: An observational, descriptive, cross-sectional study using the Framingham score was conducted with 107 public transportation drivers in the city of Teresina

  19. [Cardiovascular risk by Framingham and SCORE in patients 40-65 years old].

    Science.gov (United States)

    González, Carmen; Rodilla, Enrique; Costa, José A; Justicia, Jorge; Pascual, José M

    2006-04-15

    The aim of this study was to compare the clinical and treatment implications of 2 cardiovascular risk stratification systems in a population of patients 40-65 years old. 929 non diabetic patients (40-65 years old) (51% female) with no evidence of previous cardiovascular disease were included in the study. The risk of cardiovascular death was assessed with the charts of the Systematic Coronary Risk Evaluation (SCORE), and coronary risk by the Framingham function (National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults -NCEP-ATP-III-). Patients were considered of high risk if risk of cardiovascular death was >or= 5% and coronary risk was > 20%, respectively. 4.1% of patients were considered as high risk by SCORE and 2.5% by Framingham. Only 0.2% of females were classified as high risk with either system. 8.2% and 4.8% of male population were considered as high risk by SCORE and Framingham, respectively. There was a low level of concordance between both systems. Patients classified as high risk by SCORE but not by Framingham were older, smoke less and had a better lipid profile. According to European Guidelines 28% of male and 23% of female were candidates to hypolipemic treatment, that proportion was higher, 43% of males and 28% of females, by NCEP-ATP-III guidelines. In Spanish patients 40-65 years old, SCORE charts almost duplicate the number of high risk individuals compared to Framingham. although the number of patients candidates to hypolipemic treatment is lower with the European than ATP-III guidelines. Differences were more evident in male.

  20. Changes in erectile dysfunction over time in relation to Framingham cardiovascular risk in the Boston Area Community Health (BACH) Survey.

    Science.gov (United States)

    Fang, Shona C; Rosen, Raymond C; Vita, Joseph A; Ganz, Peter; Kupelian, Varant

    2015-01-01

    Erectile dysfunction (ED) is associated with cardiovascular disease (CVD); however, the association between change in ED status over time and future underlying CVD risk is unclear. The aim of this study was to investigate the association between change in ED status and Framingham CVD risk, as well change in Framingham risk. We studied 965 men free of CVD in the Boston Area Community Health (BACH) Survey, a longitudinal cohort study with three assessments. ED was assessed with the five-item International Index of Erectile Function at BACH I (2002-2005) and BACH II (2007-2010) and classified as no ED/transient ED/persistent ED. CVD risk was assessed with 10-year Framingham CVD risk algorithm at BACH I and BACH III (2010-2012). Linear regression models controlled for baseline age, socio-demographic and lifestyle factors, as well as baseline Framingham risk. Models were also stratified by age (≥/< 50 years). Framingham CVD risk and change in Framingham CVD risk were the main outcome measures. Transient and persistent ED was significantly associated with increased Framingham risk and change in risk over time in univariate and age-adjusted models. In younger men, persistent ED was associated with a Framingham risk that was 1.58 percentage points higher (95% confidence interval [CI]: 0.11, 3.06) and in older men, a Framingham risk that was 2.54 percentage points higher (95% CI: -1.5, 6.59), compared with those without ED. Change in Framingham risk over time was also associated with transient and persistent ED in men <50 years, but not in older men. Data suggest that even after taking into account other CVD risk factors, transient and persistent ED is associated with Framingham CVD risk and a greater increase in Framingham risk over time, particularly in younger men. Findings further support clinical assessment of CVD risk in men presenting with ED, especially those under 50 years. © 2014 International Society for Sexual Medicine.

  1. David Cronenberg y el cuerpo abierto

    Directory of Open Access Journals (Sweden)

    Johanna Rodríguez Ahumada

    2014-12-01

    Full Text Available En la sociedad actual, la relación entre el cuerpo y la tecnología ha planteado una de las fisuras más importantes en la concepción de la subjetividad. La enigmática y fascinante relación entre el humano y la máquina, explorada tanto por el cine como por otros (viejos y nuevos medios en el ámbito de la ciencia ficción, ha planteado la figura del cyborg u organismo cibernético como una criatura híbrida, ambigua, que rompe con la dicotomía naturaleza-artificialidad. ¿Cómo leer los nuevos productos culturales que surgen a raíz de la revolución tecnológica? El objeto de este estudio es Crash (David Cronenberg ,1995, que parte de una interpretación audiovisual de la novela de J.G. Ballard y aborda las fantasías de hibridación del yo con el otro, de lo orgánico con lo inorgánico; en últimas, de cuerpos en tránsito.

  2. Boundaries and interfaces in materials: The David A. Smith symposium

    International Nuclear Information System (INIS)

    Pond, R.C.; Clark, W.A.T.; King, A.H.; Williams, D.B.

    1998-01-01

    Just over a year ago David Smith died. Then the loss of a distinguished scientist and dedicated teacher was mourned. Now it is time to celebrate his accomplishments both as a scientist and teacher and this book serves as a reminder of his many contributions to the field of boundaries and interfaces. Researchers from ten countries contributed their work to the symposium, many of whom were former students of David from his years in Oxford. This emphasizes David's tremendous effect on the career of many established scientists through his role as both a teacher and an advisor. Separate abstracts were prepared for 38 papers in this book

  3. Dr. David Syz, State Secretary for Economic Affairs, Switzerland

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Dr. David Syz, State Secretary for Economic Affairs, Switzerland, toured the assembly hall of the ATLAS experiment on a recent visit to CERN.Photos 01, 02: Dr. Peter Jenni, spokesperson for the ATLAS experiment (second from left), explains to Dr. David Syz (fourth from left) and accompanying visitors the process of integration of a 26-metre-long coil of the barrel toroid magnet system into its coil casing.Photo 03: Dr. Peter Jenni (extreme right) with Dr. David Syz (front row, fourth from right) behind a stack of 26-metre-long 'racetrack' coils awaiting integration into their coil casings.

  4. David Barker: the revolution that anticipates existence

    Directory of Open Access Journals (Sweden)

    Italo Farnetani

    2014-01-01

    Full Text Available David Barker is the man who “anticipated" the existence of babies by focusing attention on the importance of the fetus and what takes place during intrauterine life. Barker was one of the physicians who in the last decades brought about the greatest changes in medicine, changes so important as to represent a veritable revolution in medical thought. According to Barker's studies, the embryo obviously has a genetic complement coming from the mother and father, but from the very first stages of development it begins to undergo the influence of the outside environment, just as occurs for adults whose biological, psychological and pathological aspects are influenced by the environment to a not well-established percentage between genetic complement and epigenetics. Much of our future lives as adults is decided in our mothers' wombs. If Barker's discovery was revolutionary from the cultural standpoint, it was even more so from the strictly medical one. Barker's research method was rigid from the methodological standpoint, but innovative and speculative in its working hypotheses, with a humanistic slant. Barker's idea has another practical corollary: it is evident that the role of obstetricians, perinatologists and neonatologists is more and more relevant in medicine and future prevention. Unquestionably, besides the enormous merits of his clinical research, among the benefits that Barker has contributed there is that of having helped us to see things from new points of view. Not only is the neonate (and even more so the fetus not an adult of reduced proportions, but perhaps the neonate is the "father" of the adult person.

  5. NOAA Ship David Starr Jordan Underway Meteorological Data, Quality Controlled

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship David Starr Jordan Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic...

  6. David Nolfi Receives NAHRS Award for Professional Excellence

    Directory of Open Access Journals (Sweden)

    Maureen Diana Sasso

    2013-09-01

    Full Text Available News AnnouncementDavid A. Nolfi, MLS, AHIP, Health Sciences Librarian & Library Assessment Coordinator at Duquesne University’s Gumberg Library, received the 2013 NAHRS Award for Professional Excellence at the One Health Conference in Boston, MA.

  7. Suurbritannia poliitikud on rahvast petnud / David Hathaway ; ref. Hille Simm

    Index Scriptorium Estoniae

    Hathaway, David

    2003-01-01

    Ülevaade 26. augustil 2003 ajakirja Eurovision peatoimetaja David Hathaway poolt Tallinnas peetud loengust, teemaks Euroopa Liidu negatiivsed mõjud Suurbritannia majanduslikule arengule ja enesemääramisõigusele

  8. Eesti keel barbarite suus / David J. Peterson ; intervjueerinud Peeter Helme

    Index Scriptorium Estoniae

    Peterson, David J.

    2011-01-01

    USA telekanali HBO telesarjas "Troonide mäng" (mis on George R. R. Martini "Jää ja tule laulu" sarja esimese raamatu "Troonide mäng" teleekraniseering) tegeles dothraki keele loomisega keeleteadlane David J. Peterson

  9. Optical packet networks - conclusions from the IST DAVID project

    DEFF Research Database (Denmark)

    Dittmann, Lars

    2004-01-01

    This work outlines the result from the European research project DAVID working with optical packet switch solutions for both WAN and MAN. The project started July 2000 and has been completed successfully by the end of 2003.......This work outlines the result from the European research project DAVID working with optical packet switch solutions for both WAN and MAN. The project started July 2000 and has been completed successfully by the end of 2003....

  10. Kommunist mittekommunisti ei usalda / David Satter ; interv. Viktor Niitsoo

    Index Scriptorium Estoniae

    Satter, David

    2005-01-01

    Tallinnas esitles oma raamatut "Meeletuste ajastu. Nõukogude Liidu allakäik ja langus" Finacial Times'i endine Moskva korrespondent David Satter, tegemist on NL-i viimase viieteistkümne aasta koondkroonikaga. Intervjuus meenutab David Satter oma tööaastaid Moskvas 1976-1982. a., kus ta keskendus põhiliselt ühiskondlik-poliitilistele teemadele, kaasa arvatud dissidentlik liikumine. Suhted võimudega, KGB provokatsioonid

  11. A Study of Correlation of Neck Circumference with Framingham Risk Score as a Predictor of Coronary Artery Disease.

    Science.gov (United States)

    Koppad, Anand K; Kaulgud, Ram S; Arun, B S

    2017-09-01

    It has been observed that metabolic syndrome is risk factor for Coronary Artery Disease (CAD) and exerts its effects through fat deposition and vascular aging. CAD has been acknowledged as a leading cause of death. In earlier studies, the metabolic risk has been estimated by Framingham risk score. Recent studies have shown that Neck Circumference (NC) has a good correlation with other traditional anthropometric measurements and can be used as marker of obesity. It also correlates with Framingham risk score, which is slightly more sophisticated measure of CAD risk. To assess the risk of CAD in a subject based on NC and to correlate the NC to Framingham risk score. The present cross-sectional study, done at Karnataka Institute of Medical Sciences, Hubli, Karnataka, India, includes 100 subjects. The study duration was of one year from 1 st January 2015 to 31 st December 2015. Anthropometric indices Body Mass Index (BMI) and NC were correlated with 10 year CAD risk as calculated by Framingham risk score. The correlation between BMI, NC, vascular age and Framingham risk score was calculated using Karl Pearson's correlation method. NC has a strong correlation with 10 year CAD risk (p≤0.001). NC was significantly greater in males as compared to females (p≤0.001). Males had greater risk of cardiovascular disease as reflected by higher 10 year Framingham risk score (p≤0.0035). NC gives simple and easy prediction of CAD risk and is more reliable than traditional risk markers like BMI. NC correlates positively with 10 year Framingham risk score.

  12. Obituary: David Q. Wark, 1918-2002

    Science.gov (United States)

    McMillin, Larry Max

    2003-12-01

    David Q. Wark, a research meteorologist at the National Environmental Satellite, Data, and Information Service of the National Oceanic and Atmospheric Administration (NOAA/NESDIS) and its predecessor organizations for 55 years, died of cancer 30 July 2002. He will be long remembered for his seminal contributions to the weather satellite program. A pioneer in the use of satellite sensors to provide observations of the Earth's environment for application to weather forecasting and atmospheric science, Dr. Wark was noted for his brilliant insights, dedication, and exceptional scientific achievements. He developed many of the theoretical and experimental techniques on which NOAA's current multi- billion-dollar meteorological satellite program is based. In the 1960's and early 1970's, he and his NOAA colleague Donald Hilleary were the motivating force and principal investigators for the first satellite instruments dedicated to sounding the atmosphere for temperature and water-vapor. These instruments included the Satellite Infra-Red Spectrometer (SIRS)-A and -B and the Vertical Temperature Profile Radiometer (VTPR), which were flown on NASA's Nimbus satellites and NOAA's ITOS-D satellites, respectively. With colleague Henry Fleming, he formulated the radiative transfer equation that quantifies the spectral radiances of the Earth and its atmosphere (measured at satellite altitude) and inverted that equation mathematically to infer the atmospheric temperature profile from satellite-based measurements of those radiances. A difficulty they had to overcome was that the mathematical problem is ill-posed, i.e., it admits of an infinite number of solutions. They arrived at a unique solution via an innovative application of a-priori information on the atmospheric state. This work was described in the landmark 1965 Wark and Fleming paper in the American Meteorological Society's Monthly Weather Review. From that early period until just weeks before his death, Dr. Wark continued

  13. Obituary: David Fulmer Bender, 1913-2004

    Science.gov (United States)

    Miller, Sylvia L.

    2004-12-01

    David Fulmer Bender died in San Diego, California, on 13 September 2004, at the age of 91. His heart stopped suddenly while he was dancing. His pioneering work in establishing comprehensive, computer-accessible ephemerides of asteroids and comets found many applications, including the first-ever visit to an asteroid, Gaspra, by an interplanetary spacecraft. Dave was born in Reno, Nevada, on 10 February 1913, to Homer Charles Bender and Susan Bowers Bender. The family moved to Spokane, Washington, while Dave was very young. His father was a civil engineer and a graduate of MIT, who helped design bridges and dams throughout the Northwest, including the Grand Coolie Dam. Dave had a brother, Phillip (now deceased), who was one year younger. Advancing rapidly in the Spokane school system, Dave finished high school when he was 15 years old. At 16 he moved to Pasadena, California, and began his studies at the California Institute of Technology (Caltech). In addition to pursuing his course work, he was active in track and football, a tendency toward physical exercise that stayed with him for the rest of his life. It was probably during these years that Dave heard a lecture by Albert Einstein, as mentioned to colleagues many years later. Dave received a BS degree in physics in 1933, an MS in 1934, and a PhD in 1937, all from Caltech. His dissertation was entitled, "The Index of Refraction of Air in the Photographic Infrared." During his sophomore year he found his way to Pomona College in Claremont, California, where he met his future wife, Elizabeth Boyden at a social gathering. They were married in 1935. Dave's academic career spanned the years from 1937 to 1970, initially at Louisiana State University, Vanderbilt University, and then Fisk. As a life-long pacifist and conscientious objector, Dave served alternate duty during World War II. In 1946 he joined the faculty of the physics department at Whittier College in California, where he became the department chair and

  14. INTRODUCTION: David Sherrington as a mentor of young scientists

    Science.gov (United States)

    Goldbart, Paul M.

    2008-08-01

    How deeply honoured I am to have the opportunity to express my thoughts at this delightful celebration of David's achievements, so far, in his remarkable career. I have been asked to center my remarks on David's contributions to the mentoring and professional development of scientists early in their careers. This is a topic that I am more than happy to reflect on, because it gives me the opportunity to recall the exciting period I spent as one of David's postgraduate students at Imperial College in the early 1980s. It also gives me the chance to publicly express my gratitude to David for the opportunities he created for me at that time, as well as for the interest and care he has shown in my career and well-being ever since, as we have met up and exchanged news and ideas around the world: in New Mexico and Colorado, in Cancun, Paris and Trieste, at numerous March Meetings of the American Physical Society and, of course in London, Oxford, and my home town, Champaign-Urbana, location of the University of Illinois. I have been a member of David's circle for 25 years now, and I would like to tell you a little about how this came to be. Not because of what this says about me, but, rather, because of what it tells you about David and the rich generosity of his spirit and effort when it comes to supporting the underdog. I was indeed one such underdog—and that's putting it charitably—when I first met David in September of 1982, not long before the academic year was to begin. I had heard about the exciting circle of physical and mathematical ideas swirling around the spin glass question during the previous year, which I had spent at the University of California's Los Angeles campus, through an opportunity kindly arranged, as it happens, by Sam Edwards. But I was eager to return to the UK for postgraduate studies and to work on spin glasses, so I simply showed up at David's Imperial College office, unannounced (if I remember correctly). And with his characteristic

  15. Avignoni totaalne teatrifestival / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Avignoni teatrifestivalil nähtust. Lähemalt Marc Wolters'i ühemeheteater "Colt Warmers", Chapelle Sainte Claire (Alfred Jarry) "Kuningas Ubu", Herman Hesse "Sidharta" mängituna India teatritrupi poolt, "Movin' Melvin Brown : Me, Ray Charles and Sammy D. Jr" ning Virgine Mirabeau koreograafial tantsuetendus "Shoult I Stay Or..." Art's Fusion esituses

  16. The 2012 Nobel Prize in physics and David Wineland

    International Nuclear Information System (INIS)

    Mark, Um; Kihwan, Kim

    2013-01-01

    The 2012 Nobel prize in physics was awarded to David Wineland, together with Serge Haroche. David Wineland received the prize for ground-breaking experimental methods that enabled the measurement and manipulation of individual quantum systems, especially systems with trapped ions. He improved a trapped ion system and opened a new quantum world leading to quantum computation. He also realized optical atomic ion clocks with unprecedented precision through his experimental research. This article briefly reviews the history of trapped ion systems, the development of trapped-ion based quantum computation, and the development of the atomic ion clock, which are closely related to Wineland's achievements. (authors)

  17. Framingham coronary heart disease risk score can be predicted from structural brain images in elderly subjects.

    Directory of Open Access Journals (Sweden)

    Jane Maryam Rondina

    2014-12-01

    Full Text Available Recent literature has presented evidence that cardiovascular risk factors (CVRF play an important role on cognitive performance in elderly individuals, both those who are asymptomatic and those who suffer from symptoms of neurodegenerative disorders. Findings from studies applying neuroimaging methods have increasingly reinforced such notion. Studies addressing the impact of CVRF on brain anatomy changes have gained increasing importance, as recent papers have reported gray matter loss predominantly in regions traditionally affected in Alzheimer’s disease (AD and vascular dementia in the presence of a high degree of cardiovascular risk. In the present paper, we explore the association between CVRF and brain changes using pattern recognition techniques applied to structural MRI and the Framingham score (a composite measure of cardiovascular risk largely used in epidemiological studies in a sample of healthy elderly individuals. We aim to answer the following questions: Is it possible to decode (i.e., to learn information regarding cardiovascular risk from structural brain images enabling individual predictions? Among clinical measures comprising the Framingham score, are there particular risk factors that stand as more predictable from patterns of brain changes? Our main findings are threefold: i we verified that structural changes in spatially distributed patterns in the brain enable statistically significant prediction of Framingham scores. This result is still significant when controlling for the presence of the APOE 4 allele (an important genetic risk factor for both AD and cardiovascular disease. ii When considering each risk factor singly, we found different levels of correlation between real and predicted factors; however, single factors were not significantly predictable from brain images when considering APOE4 allele presence as covariate. iii We found important gender differences, and the possible causes of that finding are discussed.

  18. Unique dietary patterns and chronic disease risk profiles of adult men: the Framingham nutrition studies.

    Science.gov (United States)

    Millen, Barbara E; Quatromoni, Paula A; Pencina, Michael; Kimokoti, Ruth; Nam, Byung-H O; Cobain, Sonia; Kozak, Waldemar; Appugliese, Danielle P; Ordovas, Jose; D'Agostino, Ralph B

    2005-11-01

    To identify the dietary patterns of adult men and examine their relationships with nutrient intake and chronic disease risk over long-term follow-up. Baseline 145-item food frequency questionnaires from 1,666 Framingham Offspring-Spouse cohort men were used to identify comprehensive dietary patterns. Independent 3-day dietary records at baseline and 8 years later provided estimates of subjects' nutrient intake by dietary pattern. Chronic disease risk factor status was compared at baseline and 16-year follow-up across all male dietary patterns. Cluster analysis was applied to food frequency data to identify non-overlapping male dietary patterns. Analysis of covariance and logistic regression were used to compare nutrient intake, summary nutritional risk scores, and chronic disease risk status at baseline and follow-up by male dietary pattern. Five distinct and comprehensive dietary patterns of Framingham Offspring-Spouse men were identified and ordered according to overall nutritional risk: Transition to Heart Healthy, Higher Starch, Average Male, Lower Variety, and Empty Calories. Nutritional risk was high and varied by dietary pattern; key nutrient contrasts were stable over 8-year follow-up. Chronic disease risk also varied by dietary pattern and specific subgroup differences persisted over 16 years, notably rates of overweight/obesity and smoking. Quantitative cluster analysis applied to food frequency questionnaire data identified five distinct, comprehensive, and stable dietary patterns of adult Framingham Offspring-Spouse cohort men. The close associations between the dietary patterns, nutritional risk, and chronic disease profiles of men emphasize the importance of targeted preventive nutrition interventions to promote health in the male population.

  19. Detection and severity of coronary disease: comparison between Framingham and calcium scores using multi-slice tomography

    International Nuclear Information System (INIS)

    Rodriguez Gomez, Maria Liliana; Montenegro, Edison; Ruiz, Angela Maria; Ardila, Jaime

    2011-01-01

    Introduction: multiple studies have shown that the coronary calcium index is an independent, more accurate predictor of future coronary events in relation to traditional risk factors. However, these studies have not been conducted in populations of developing countries like Colombia. Objective: to compare the strength of association between the Framingham index and the coronary calcium score in detecting the presence and severity of coronary disease as defined by 64-channel multi-slice angio-CT in order to provide additional information for decision-making in our asymptomatic coronary population. Methodology: we reviewed the written reports of coronary angiography scans performed in past 3 years. Based on this information, bivariate (calculation of Spearman rho correlation coefficients) and multivariate (logistic regression) analyses were performed. Results: the coronary calcium score showed a higher correlation with the presence and severity of coronary disease, Spearman Rho coefficient, compared with the Framingham index, Spearman's Rho coefficient of 0.30 (p<0.001). The moderate Framingham index (10-19%) shows no strength of association with significant and non-significant coronary artery disease, OR = 2, 51 CI 95% (0.7-8.9) and OR = 2.3 CI 95% (0.86-6.15), respectively. Patients with calcium values = 100 showed significant strength of association, OR = 182, 95% (17.4 -190.2), with significant coronary disease compared with high Framingham index values (=20%), OR = 18.6, CI 95% (1.75-198). Conclusions: the coronary calcium score has a higher correlation with the presence and severity of coronary disease when compared with the Framingham index. There is a low correlation between the index and Framingham coronary calcium.

  20. Dr. David Sawyer, Mickey Mouse and Dr. David Brown attend a ceremony at Ronald McNair Middle School

    Science.gov (United States)

    1999-01-01

    Dr. David Sawyer (left), Superintendent of the Brevard County School District, Mickey Mouse, and Dr. David Brown, a NASA astronaut, attend a tribute to NASA astronaut Ronald McNair held in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. During the tribute, Walt Disney World presented a portrait of McNair to the school, which had previously been renamed for the fallen astronaut. McNair was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  1. Movers and shakers: David M. Malone | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-01-25

    Jan 25, 2011 ... ... been met with praise in the two worlds that he has known best—diplomacy and research. ... Malone addressed this internal criticism while serving a six-year term as .... “And David probably did as well as anybody ever has.”.

  2. Nähtamatu revolutsioon / David R. Smith ; interv. Philip Ball

    Index Scriptorium Estoniae

    Smith, David R.

    2007-01-01

    Tehisstruktuuriga metamaterjalid võivad põhjapanevalt muuta telekommunikatsiooni, andmekandjaid ja isegi päikeseenergeetikat, kinnitab Dukeѫi ülikooli töörühma juht David R. Smith. Artikkel üldpealkirja all: 10 tulevikutehnoloogiat 2007

  3. Highlight: Dr David Butler-Jones on fighting pandemics | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 avr. 2016 ... Dr David Butler-Jones, professor in the Faculty of Medicine at the University of Manitoba and former Chief Medical Health Officer of Canada, delivered a lecture on lessons learned from the 2009 flu pandemic in Canada. He also commented on India's draft National Health Policy 2015 at the India ...

  4. "The Word I Would Use Is 'Aesthetic'": Reading David Hawkins.

    Science.gov (United States)

    Featherstone, Helen; Featherstone, Joseph

    2002-01-01

    Discusses the life of David Hawkins, one of the most influential educators involved in school reform in the 1960s. Focuses on the aesthetic as the center of Hawkins' vision of schooling. Compares Hawkins' perspective to Dewey's in terms of the aesthetic. (KHR)

  5. 2012-2013 Expense report for David Malone | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2012-2013 Expense report for David Malone. Download PDF of Expense Report 2012-2013 · What we do · Funding · Resources · About IDRC. Knowledge. Innovation. Solutions. Careers · Contact Us · Site map. Sign up now for IDRC news and views sent directly to your inbox each month. Subscribe · Copyright · Open ...

  6. 2010-2011 Expense report for David Malone | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-2011 Expense report for David Malone. Download PDF of Expense Report 2010-2011 · What we do · Funding · Resources · About IDRC. Knowledge. Innovation. Solutions. Careers · Contact Us · Site map. Sign up now for IDRC news and views sent directly to your inbox each month. Subscribe · Copyright · Open ...

  7. 2011-2012 Expense report for David Malone | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-2012 Expense report for David Malone. Download PDF of Expense Report 2011-2012 · What we do · Funding · Resources · About IDRC. Knowledge. Innovation. Solutions. Careers · Contact Us · Site map. Sign up now for IDRC news and views sent directly to your inbox each month. Subscribe · Copyright · Open ...

  8. Drawing borders of mental disorders : An interview with David Kupfer

    NARCIS (Netherlands)

    Verhoeff, Berend

    2010-01-01

    The new Diagnostic and Statistical Manual of Mental Disorders (DSM-5) is on its way and will most likely be published in 2013. The chair of the task force of this significant project, Dr David Kupfer, was in the Netherlands at a national psychiatry conference to give an update on its progress.

  9. Battling Creaticide: An Interview with David C. Berliner

    Science.gov (United States)

    Ambrose, Don

    2012-01-01

    This article presents an interview with David C. Berliner, a Regents' Professor in the College of Education at Arizona State University. His books include "Educational Psychology," "The Manufactured Crisis," and "The Handbook of Educational Psychology." He has served as president of the American Educational Research Association and of the…

  10. Instructional Implications of David C. Geary's Evolutionary Educational Psychology

    Science.gov (United States)

    Sweller, John

    2008-01-01

    David C. Geary's thesis has the potential to alter our understanding of those aspects of human cognition relevant to instruction. His distinction between biologically primary knowledge that we have evolved to acquire and biologically secondary knowledge that is culturally important, taught in educational institutions and which we have not evolved…

  11. In Memoriam: David Judson Sencer, A Public Health Giant

    Centers for Disease Control (CDC) Podcasts

    2011-12-15

    Dr. Jeffery Koplan, Director of the Emory Global Health Institute at Emory University, reflects on the career of Dr. David Sencer.  Created: 12/15/2011 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 12/19/2011.

  12. David Almond's "Skellig": "A New Vista of Contemplation"?

    Science.gov (United States)

    Stewart, Susan Louise

    2009-01-01

    The debates that have arisen regarding Darwin's theories of evolution and Christian views of creation and their place in education in the United States have frequently been extremely heated, resulting in trials, hearings, and laws. This article provides an overview of some of the disagreements and illustrates how David Almond's British novel,…

  13. “From the Mind of David Simon”

    DEFF Research Database (Denmark)

    Jensen, Mikkel Bo Brendstrup

    2017-01-01

    This article makes a case for the academic soundness of reading together several television shows by the same showrunner. Zeroing in on the case of David Simon, the essay traces the difficulties that one faces if one aims to view together The Corner, The Wire, Generation Kill, Treme, Show Me a Hero...

  14. David i fortællingen i verden

    DEFF Research Database (Denmark)

    Hasselbalch, Trine Bjørnung

    2013-01-01

    Interpretations of the narratives about David in the Books of Samuel can be divided roughly into works that understand them one way or the other as products of history, and works that tend to disregard questions about their historical conditions. But neither strategy – studying the meaning...

  15. Child Welfare Research and Training: A Response to David Stoesz

    Science.gov (United States)

    Smith, Brenda D.; Vandiver, Vikki L.

    2016-01-01

    In this response to David Stoesz' critique, "The Child Welfare Cartel," the authors agree that child welfare research and training must be improved. The authors disagree, however, with Stoesz' critique of social work education, his assessment of the most-needed forms of child welfare research, and his depiction of the goals and…

  16. Empowering Adolescent Readers: Intertextuality in Three Novels by David Almond

    Science.gov (United States)

    Latham, Don

    2008-01-01

    In "Skellig," "Kit's Wilderness," and "Clay", David Almond employs various types of intertextuality to enrich his narratives. Through the use of allusion, adaptation, collage, and mise-en-abyme, he encourages his adolescent readers to seek out precursor texts and to consider the interrelationships between these texts and his own. By so doing, he…

  17. High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort.

    Science.gov (United States)

    Paul, Ligi; Jacques, Paul F; Aviv, Abraham; Vasan, Ramachandran S; D'Agostino, Ralph B; Levy, Daniel; Selhub, Jacob

    2015-03-01

    Shortening of telomeres, the protective structures at the ends of eukaryotic chromosomes, is associated with age-related pathologies. Telomere length is influenced by DNA integrity and DNA and histone methylation. Folate plays a role in providing precursors for nucleotides and methyl groups for methylation reactions and has the potential to influence telomere length. We determined the association between leukocyte telomere length and long-term plasma folate status (mean of 4 years) in Framingham Offspring Study (n = 1,044, females = 52.1 %, mean age 59 years) using data from samples collected before and after folic acid fortification. Leukocyte telomere length was determined by Southern analysis and fasting plasma folate concentration using microbiological assay. There was no significant positive association between long-term plasma folate and leukocyte telomere length among the Framingham Offspring Study participants perhaps due to their adequate folate status. While the leukocyte telomere length in the second quintile of plasma folate was longer than that in the first quintile, the difference was not statistically significant. The leukocyte telomere length of the individuals in the fifth quintile of plasma folate was shorter than that of those in the second quintile by 180 bp (P folate concentrations in the upper four quintiles of plasma folate (P for trend = 0.001). Multivitamin use was associated with shorter telomeres in this cohort (P = 0.015). High plasma folate status possibly resulting from high folic acid intake may interfere with the role of folate in maintaining telomere integrity.

  18. David Bruce Payton : väikeriigid mõistavad üksteist / David Bruce Payton ; interv. Marianne Mikko

    Index Scriptorium Estoniae

    Payton, David Bruce

    2003-01-01

    Uus-Meremaa suursaadik Eestis David Bruce Payton talupidaja toetamise loobumisest Uus-Meremaal, Uus-Meremaa põllumajandussektorist, veinidest, ekspordist, Eesti saamisest EL-i ja NATO liikmeks, Uus-Meremaa rahvastikust, elatustasemest, Iraagi võimalikust ründamisest, Põhja-Koreast

  19. Attitudes of Mississippi College Students toward David Duke before and after Seeing the Film "Who Is David Duke?"

    Science.gov (United States)

    Eisenman, Russell; And Others

    1993-01-01

    Investigated attitudes of 211 college students in Mississippi before and after viewing film "Who Is David Duke?" which provided evidence of Duke's current racism, anti-Semitism, and pro-Nazi leanings. Previous study with students in Louisiana, majority did not change attitudes after viewing film. In present study, students' attitudes…

  20. Ten years cardiovascular risk estimation according to Framingham score and non HDL-cholesterol in blood donors.

    Science.gov (United States)

    Graffigna, Mabel Nora; Berg, Gabriela; Migliano, Marta; Salgado, Pablo; Soutelo, Jimena; Musso, Carla

    2015-01-01

    Cardiovascular disease (CVD) is currently the primary cause of morbidity and mortality. (1) Assess the 10 years risk for CVD in Argentinean blood donors, according to Framingham score (updated by ATP III), (2) evaluate the prevalence of the MS, (3) evaluate non HDL-cholesterol level in this population as other risk for CVD. A prospective, epidemiological, transversal study was performed to evaluate 585 volunteer blood donors for two years. Non HDL-C was calculated as total cholesterol minus HDL-C and we evaluated the 10 years risk for CVD according to Framingham score (updated by ATP III). Metabolic syndrome prevalence was estimated according to ATP III and IDF criteria. Non HDL-C was (media±SD) 178.3±48.0 mg/dl in participants with MS and 143.7±39.3 mg/dl without MS (ATPIII) and 160.1±43.6 mg/dl in participants with MS and 139.8±43.1 mg/dl without MS (IDF). Participants with MS presented an OR of 3.1; IC 95% (2-5) of CVD according to de Framingham score. Individuals with MS and elevated non HDL-C are at a higher estimated risk for cardiovascular events in the next 10 years according to the Framingham risk score. Copyright © 2014. Published by Elsevier Ltd.

  1. CMR reference values for left ventricular volumes, mass, and ejection fraction using computer-aided analysis : The Framingham Heart Study

    NARCIS (Netherlands)

    Chuang, Michael L.; Gona, Philimon; Hautvast, Gilion L.T.F.; Salton, Carol J.; Breeuwer, Marcel; O'Donnell, Christopher J.; Manning, Warren J.

    Purpose To determine sex-specific reference values for left ventricular (LV) volumes, mass, and ejection fraction (EF) in healthy adults using computer-aided analysis and to examine the effect of age on LV parameters. Materials and Methods We examined data from 1494 members of the Framingham Heart

  2. Coronary risk assessment by point-based vs. equation-based Framingham models: significant implications for clinical care.

    Science.gov (United States)

    Gordon, William J; Polansky, Jesse M; Boscardin, W John; Fung, Kathy Z; Steinman, Michael A

    2010-11-01

    US cholesterol guidelines use original and simplified versions of the Framingham model to estimate future coronary risk and thereby classify patients into risk groups with different treatment strategies. We sought to compare risk estimates and risk group classification generated by the original, complex Framingham model and the simplified, point-based version. We assessed 2,543 subjects age 20-79 from the 2001-2006 National Health and Nutrition Examination Surveys (NHANES) for whom Adult Treatment Panel III (ATP-III) guidelines recommend formal risk stratification. For each subject, we calculated the 10-year risk of major coronary events using the original and point-based Framingham models, and then compared differences in these risk estimates and whether these differences would place subjects into different ATP-III risk groups (20% risk). Using standard procedures, all analyses were adjusted for survey weights, clustering, and stratification to make our results nationally representative. Among 39 million eligible adults, the original Framingham model categorized 71% of subjects as having "moderate" risk (20%) risk. Estimates of coronary risk by the original and point-based models often differed substantially. The point-based system classified 15% of adults (5.7 million) into different risk groups than the original model, with 10% (3.9 million) misclassified into higher risk groups and 5% (1.8 million) into lower risk groups, for a net impact of classifying 2.1 million adults into higher risk groups. These risk group misclassifications would impact guideline-recommended drug treatment strategies for 25-46% of affected subjects. Patterns of misclassifications varied significantly by gender, age, and underlying CHD risk. Compared to the original Framingham model, the point-based version misclassifies millions of Americans into risk groups for which guidelines recommend different treatment strategies.

  3. David Bohm la physique de l'infini

    CERN Document Server

    Teodorani, Massimo

    2014-01-01

    Les idées de David Bohm, indépendamment du scepticisme de ses collègues les plus traditionalistes, ont profondément influencé la physique du siècle dernier et ouvert une porte à la physique du nouveau millénaire. Grâce aussi aux contacts qu'il sut nouer avec des chercheurs d'autres branches du savoir, ses idées ont été accueillies avec beaucoup d'enthousiasme par les neuroscientifiques, les philosophes, les théologiens, les psychologues, les sociologues, les poètes, les artistes et les éducateurs. David Bohm avait peut-être pressenti qu'il existe une "physique de l'âme" et avec elle il voulait tracer un nouveau chemin pour une humanité à la dérive.

  4. DAVID: A new video motion sensor for outdoor perimeter applications

    International Nuclear Information System (INIS)

    Alexander, J.C.

    1986-01-01

    To be effective, a perimeter intrusion detection system must comprise both sensor and rapid assessment components. The use of closed circuit television (CCTV) to provide the rapid assessment capability, makes possible the use of video motion detection (VMD) processing as a system sensor component. Despite it's conceptual appeal, video motion detection has not been widely used in outdoor perimeter systems because of an inability to discriminate between genuine intrusions and numerous environmental effects such as cloud shadows, wind motion, reflections, precipitation, etc. The result has been an unacceptably high false alarm rate and operator work-load. DAVID (Digital Automatic Video Intrusion Detector) utilizes new digital signal processing techniques to achieve a dramatic improvement in discrimination performance thereby making video motion detection practical for outdoor applications. This paper begins with a discussion of the key considerations in implementing an outdoor video intrusion detection system, followed by a description of the DAVID design in light of these considerations

  5. 2690-IJBCS-Article-N'goran David Vincent K

    African Journals Online (AJOL)

    hp

    régime fourrager supplémenté par la farine de poisson et/ou du maïs-grain durant le cycle de reproduction. N'Goran David Vincent KOUAKOU* et Yao Brice Savier BROU. Département de Formation et de Recherche Agriculture et Ressources animales, Institut National. Polytechnique Félix Houphouët-Boigny, B.P. 1313 ...

  6. Dr. David Syz, State Secretary for Economic Affairs, Switzerland

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Dr. David Syz, State Secretary for Economic Affairs, Switzerland is seen here (seventh from right) visiting the assembly hall for the ATLAS experiment during his recent visit to CERN. To his right is Dr. Peter Jenni (blue shirt), spokesperson for the ATLAS Collaboration. The horizontal metal cylinder behind the group is one of the eight vacuum vessels for the superconducting coils of the ATLAS barrel toroid magnet system.

  7. David Cronenberg, author of naked lunch: Intersemiotic translation as transcreation

    Directory of Open Access Journals (Sweden)

    Rosângela Fachel de Medeiros

    2016-05-01

    Full Text Available This paper presents and analyzes the intersemiotic translation process performed by filmmaker David Cronenberg of William Burroughs' novel Naked Lunch, and the intertextual bifurcations involved in this process. Investigating the similarities and differences between the creative worlds of both artists and how they reframe each other. For this, are used as the theoretical the idea of transcreation proposed by Haroldo de Campos, and the notion of the translator as a reader proposed by Jorge Luis Borges.

  8. Job Strain and Cognitive Decline: A Prospective Study of the Framingham Offspring Cohort

    Directory of Open Access Journals (Sweden)

    W Agbenyikey

    2015-04-01

    Full Text Available Background: Workplace stress is known to be related with many behavioral and disease outcomes. However, little is known about its prospective relationship with measures of cognitive decline. Objective: To investigate the association of job strain, psychological demands and job control on cognitive decline. Methods: Participants from Framingham Offspring cohort (n=1429, were assessed on job strain, and received neuropsychological assessment approximately 15 years and 21 years afterwards. Results: High job strain and low control were associated with decline in verbal learning and memory. Job strain was associated with decline in word recognition skills. Active job and passive job predicted decline in verbal learning and memory relative to low strain jobs in the younger subgroup. Active job and demands were positively associated with abstract reasoning skills. Conclusions: Job strain and job control may influence decline in cognitive performance.

  9. Anterior mediastinal masses in the Framingham Heart Study: Prevalence and CT image characteristics

    International Nuclear Information System (INIS)

    Araki, Tetsuro; Nishino, Mizuki; Gao, Wei; Dupuis, Josée; Washko, George R.; Hunninghake, Gary M.; Murakami, Takamichi; O’Connor, George T.; Hatabu, Hiroto

    2015-01-01

    To investigate the prevalence and CT image characteristics of anterior mediastinal masses in a population-based cohort and their association with the demographics of the participants. Chest CT scans of 2571 Framingham Heart Study participants (mean age 58.9 years, 51% female) were evaluated by two board-certified radiologists with expertise in thoracic imaging for the presence of anterior mediastinal masses, their shape, contour, location, invasion of adjacent structures, fat content, and calcification. For participants with anterior mediastinal masses, a previous cardiac CT scan was reviewed for interval size change of the masses, when available. The demographics of the participants were studied for any association with the presence of anterior mediastinal masses. Of 2571, 23 participants (0.9%, 95% CI: 0.6–1.3) had anterior mediastinal masses on CT. The most common CT characteristics were oval shape, lobular contour, and midline location, showing soft tissue density (median 32.1 HU). Fat content was detected in a few cases (9%, 2/23). Six out of eight masses with available prior cardiac CT scans demonstrated an interval growth over a median period of 6.5 years. No risk factors for anterior mediastinal masses were detected among participants’ demographics, including age, sex, BMI, and cigarette smoking. The prevalence of anterior mediastinal masses is 0.9% in the Framingham Heart Study. Those masses may increase in size when observed over 5–7 years. Investigation of clinical significance in incidentally found anterior mediastinal masses with a longer period of follow-up would be necessary

  10. Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study.

    Science.gov (United States)

    Arya, Rector; Lehman, Donna; Hunt, Kelly J; Schneider, Jennifer; Almasy, Laura; Blangero, John; Stern, Michael P; Duggirala, Ravindranath

    2003-12-31

    Epidemiological studies have indicated that obesity and low high-density lipoprotein (HDL) levels are strong cardiovascular risk factors, and that these traits are inversely correlated. Despite the belief that these traits are correlated in part due to pleiotropy, knowledge on specific genes commonly affecting obesity and dyslipidemia is very limited. To address this issue, we first conducted univariate multipoint linkage analysis for body mass index (BMI) and HDL-C to identify loci influencing variation in these phenotypes using Framingham Heart Study data relating to 1702 subjects distributed across 330 pedigrees. Subsequently, we performed bivariate multipoint linkage analysis to detect common loci influencing covariation between these two traits. We scanned the genome and identified a major locus near marker D6S1009 influencing variation in BMI (LOD = 3.9) using the program SOLAR. We also identified a major locus for HDL-C near marker D2S1334 on chromosome 2 (LOD = 3.5) and another region near marker D6S1009 on chromosome 6 with suggestive evidence for linkage (LOD = 2.7). Since these two phenotypes have been independently mapped to the same region on chromosome 6q, we used the bivariate multipoint linkage approach using SOLAR. The bivariate linkage analysis of BMI and HDL-C implicated the genetic region near marker D6S1009 as harboring a major gene commonly influencing these phenotypes (bivariate LOD = 6.2; LODeq = 5.5) and appears to improve power to map the correlated traits to a region, precisely. We found substantial evidence for a quantitative trait locus with pleiotropic effects, which appears to influence both BMI and HDL-C phenotypes in the Framingham data.

  11. Foot Function, Foot Pain, and Falls in Older Adults: The Framingham Foot Study.

    Science.gov (United States)

    Awale, Arunima; Hagedorn, Thomas J; Dufour, Alyssa B; Menz, Hylton B; Casey, Virginia A; Hannan, Marian T

    2017-01-01

    Although foot pain has been linked to fall risk, contributions of pain severity, foot posture, or foot function are unclear. These factors were examined in a cohort of older adults. The purpose of this study was to examine the associations of foot pain, severity of foot pain, and measures of foot posture and dynamic foot function with reported falls in a large, well-described cohort of older adults from the Framingham Foot Study. Foot pain, posture, and function were collected from Framingham Foot Study participants who were queried about falls over the past year (0, 1, and ≥2 falls). Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the relation of falls with foot pain, pain severity, foot posture, and foot function adjusting for covariates. The mean age of the 1,375 participants was 69 years; 57% were female, and 21% reported foot pain (40% mild pain, 47% moderate pain, and 13% severe pain). One-third reported falls in the past year (1 fall: n = 263, ≥2 falls: n = 152). Foot pain was associated with a 62% increased odds of recurrent falls. Those with moderate and severe foot pain showed increased odds of ≥2 falls (OR 1.78, CI 1.06-2.99, and OR 3.25, CI 1.65-7.48, respectively) compared to those with no foot pain. Foot function was not associated with falls. Compared to normal foot posture, those with planus foot posture had 78% higher odds of ≥2 falls. Higher odds of recurrent falls were observed in individuals with foot pain, especially severe foot pain, as well as in individuals with planus foot posture, indicating that both foot pain and foot posture may play a role in increasing the risk of falls among older adults. © 2017 S. Karger AG, Basel.

  12. Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts.

    Science.gov (United States)

    Ma, Jiantao; Fox, Caroline S; Jacques, Paul F; Speliotes, Elizabeth K; Hoffmann, Udo; Smith, Caren E; Saltzman, Edward; McKeown, Nicola M

    2015-08-01

    Non-alcoholic fatty liver disease affects ∼30% of US adults, yet the role of sugar-sweetened beverages and diet soda on these diseases remains unknown. We examined the cross-sectional association between intake of sugar-sweetened beverages or diet soda and fatty liver disease in participants of the Framingham Offspring and Third Generation cohorts. Fatty liver disease was defined using liver attenuation measurements generated from computed tomography in 2634 participants. Alanine transaminase concentration, a crude marker of fatty liver disease, was measured in 5908 participants. Sugar-sweetened beverage and diet soda intake were estimated using a food frequency questionnaire. Participants were categorized as either non-consumers or consumers (3 categories: 1 serving/month to sugar-sweetened beverages or diet soda. After adjustment for age, sex, smoking status, Framingham cohort, energy intake, alcohol, dietary fiber, fat (% energy), protein (% energy), diet soda intake, and body mass index, the odds ratios of fatty liver disease were 1, 1.16 (0.88, 1.54), 1.32 (0.93, 1.86), and 1.61 (1.04, 2.49) across sugar-sweetened beverage consumption categories (p trend=0.04). Sugar-sweetened beverage consumption was also positively associated with alanine transaminase levels (p trend=0.007). We observed no significant association between diet soda intake and measures of fatty liver disease. In conclusion, we observed that regular sugar-sweetened beverage consumption was associated with greater risk of fatty liver disease, particularly in overweight and obese individuals, whereas diet soda intake was not associated with measures of fatty liver disease. Copyright © 2015 European Association for the Study of the Liver. All rights reserved.

  13. Validation of the Framingham general cardiovascular risk score in a multiethnic Asian population: a retrospective cohort study.

    Science.gov (United States)

    Chia, Yook Chin; Gray, Sarah Yu Weng; Ching, Siew Mooi; Lim, Hooi Min; Chinna, Karuthan

    2015-05-19

    This study aims to examine the validity of the Framingham general cardiovascular disease (CVD) risk chart in a primary care setting. This is a 10-year retrospective cohort study. A primary care clinic in a teaching hospital in Malaysia. 967 patients' records were randomly selected from patients who were attending follow-up in the clinic. Baseline demographic data, history of diabetes and smoking, blood pressure (BP), and serum lipids were captured from patient records in 1998. Each patient's Framingham CVD score was computed from these parameters. All atherosclerotic CVD events occurring between 1998 and 2007 were counted. In 1998, mean age was 57 years with 33.8% men, 6.1% smokers, 43.3% diabetics and 59.7% hypertensive. Median BP was 140/80 mm Hg and total cholesterol 6.0 mmol/L (1.3). The predicted median Framingham general CVD risk score for the study population was 21.5% (IQR 1.2-30.0) while the actual CVD events that occurred in the 10 years was 13.1% (127/967). The median CVD points for men was 30.0, giving them a CVD risk of more than 30%; for women it is 18.5, a CVD risk of 21.5%. Our study found that the Framingham general CVD risk score to have moderate discrimination with an area under the receiver operating characteristic curve (AUC) of 0.63. It also discriminates well for Malay (AUC 0.65, p=0.01), Chinese (AUC 0.60, p=0.03), and Indians (AUC 0.65, p=0.001). There was good calibration with Hosmer-Lemeshow test χ(2)=3.25, p=0.78. Taking into account that this cohort of patients were already on treatment, the Framingham General CVD Risk Prediction Score predicts fairly accurately for men and overestimates somewhat for women. In the absence of local risk prediction charts, the Framingham general CVD risk prediction chart is a reasonable alternative for use in a multiethnic group in a primary care setting. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  14. David Bohm : causality and chance, letters to three women

    CERN Document Server

    2017-01-01

    The letters transcribed in this book were written by physicist David Bohm to three close female acquaintances in the period 1950 to 1956. They provide a background to his causal interpretation of quantum mechanics and the Marxist philosophy that inspired his scientific work in quantum theory, probability and statistical mechanics. In his letters, Bohm reveals the ideas that led to his ground breaking book Causality and Chance in Modern Physics. The political arguments as well as the acute personal problems contained in these letters help to give a rounded, human picture of this leading scientist and twentieth century thinker.

  15. Conservative Party Modernisation and David Cameron's Politics of the Family

    OpenAIRE

    Hayton, Richard

    2010-01-01

    A key feature of David Cameron's electoral appeal is his carefully cultivated image as a ‘family man’. Cameron has repeatedly stressed the importance of the family to his political views and stated his desire to see marriage rewarded through the tax system. At the same time, Cameron has presented himself as a modernising leader, keen to demonstrate that he and his party are in touch with contemporary society. Central to this effort to detoxify the Conservative brand has been an emphasis on so...

  16. An Interview with David Dabydeen on Literature and Politics

    OpenAIRE

    Ruzbeh Babaee

    2016-01-01

    Professor David Dabydeen is a Guyanese-born writer, critic and academic at the Centre of Caribbean Studies at the University of Warwick. In 1993 he became Guyana's ambassador at UNESCO and is still a member of their Executive Board. He has been Guyana's ambassador to China since 2010. Professor Dabydeen has also won several international and national prizes such as the Commonwealth Poetry Prize, the Quiller-Couch Prize, and the Hind Rattan (Jewel of India). Among his works are Slave Song (198...

  17. "David Byrne really does love PowerPoint"

    DEFF Research Database (Denmark)

    van Leeuwen, Theo; Djonov, Emilia

    2014-01-01

    This article presents a reading if David Byrne's Envisioning Emotional Epistemological Information, an art work created with Microsoft's presentation software PowerPoint, as an instance of creative research on semiotics and semiotic technology. It reveals commonalities and differences between Byr......'s ideas about PowerPoint and related ideas from linguistics and semiotics, and is intended as a contribution to research on PowerPoint, and on semiotic technologies generally, as well as to efforts aimed at developing criteria for evaluating art as research on semiotics....

  18. Protective association of milk intake on the risk of hip fracture: Results from the Framingham Original Cohort

    OpenAIRE

    Sahni, Shivani; Mangano, Kelsey M.; Tucker, Katherine L.; Kiel, Douglas P.; Casey, Virginia A.; Hannan, Marian T.

    2014-01-01

    Dairy foods are rich in bone beneficial nutrients, yet the role of dairy foods in hip fracture prevention remains controversial. The objective was to evaluate the association of milk, yogurt, cheese, cream and milk+yogurt intakes with incident hip fracture. 830 men and women from the Framingham Original Cohort, a prospective cohort study, completed a food frequency questionnaire (1988–89) and were followed for hip fracture until 2008. In this population-based study, Cox-proportional hazards r...

  19. Cardiovascular Risk Assessment: A Comparison of the Framingham, PROCAM, and DAD Equations in HIV-Infected Persons

    Directory of Open Access Journals (Sweden)

    Max Weyler Nery

    2013-01-01

    Full Text Available This study aims to estimate the risk of cardiovascular disease (CVD and to assess the agreement between the Framingham, Framingham with aggravating factors, PROCAM, and DAD equations in HIV-infected patients. A cross-sectional study was conducted in an outpatient centre in Brazil. 294 patients older than 19 years were enrolled. Estimates of 10-year cardiovascular risk were calculated. The agreement between the CVD risk equations was assessed using Cohen's kappa coefficient. The participants' mean age was 36.8 years (SD = 10.3, 76.9% were men, and 66.3% were on antiretroviral therapy. 47.8% of the participants had abdominal obesity, 23.1% were current smokers, 20.0% had hypertension, and 2.0% had diabetes. At least one lipid abnormality was detected in 72.8%, and a low HDL-C level was the most common. The majority were classified as having low risk for CV events. The percentage of patients at high risk ranged from 0.4 to 5.7. The PROCAM score placed the lowest proportion of the patients into a high-risk group, and the Framingham equation with aggravating factors placed the highest proportion of patients into the high-risk group. Data concerning the comparability of different tools are informative for estimating the risk of CVD, but accuracy of the outcome predictions should also be considered.

  20. Ambient air pollution, adipokines, and glucose homeostasis: The Framingham Heart Study.

    Science.gov (United States)

    Li, Wenyuan; Dorans, Kirsten S; Wilker, Elissa H; Rice, Mary B; Kloog, Itai; Schwartz, Joel D; Koutrakis, Petros; Coull, Brent A; Gold, Diane R; Meigs, James B; Fox, Caroline S; Mittleman, Murray A

    2018-02-01

    To examine associations of proximity to major roadways, sustained exposure to fine particulate matter (PM 2.5 ), and acute exposure to ambient air pollutants with adipokines and measures of glucose homeostasis among participants living in the northeastern United States. We included 5958 participants from the Framingham Offspring cohort examination cycle 7 (1998-2001) and 8 (2005-2008) and Third Generation cohort examination cycle 1 (2002-2005) and 2 (2008-2011), who did not have type 2 diabetes at the time of examination visit. We calculated 2003 annual average PM 2.5 at participants' home address, residential distance to the nearest major roadway, and daily PM 2.5 , black carbon (BC), sulfate, nitrogen oxides (NO x ), and ozone concentrations. We used linear mixed effects models for fasting glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) which were measured up to twice, and used linear regression models for adiponectin, resistin, leptin, and hemoglobin A1c (HbA1c) which were measured only once, adjusting for demographics, socioeconomic position, lifestyle, time, and seasonality. The mean age was 51years and 55% were women. Participants who lived 64m (25th percentile) from a major roadway had 0.28% (95% CI: 0.05%, 0.51%) higher fasting plasma glucose than participants who lived 413m (75th percentile) away, and the association appeared to be driven by participants who lived within 50m from a major roadway. Higher exposures to 3- to 7-day moving averages of BC and NO x were associated with higher glucose whereas the associations for ozone were negative. The associations otherwise were generally null and did not differ by median age, sex, educational attainment, obesity status, or prediabetes status. Living closer to a major roadway or acute exposure to traffic-related air pollutants were associated with dysregulated glucose homeostasis but not with adipokines among participants from the Framingham Offspring and Third Generation

  1. Attitudes of Mississippi college students toward David Duke before and after seeing the film Who is David Duke?

    Science.gov (United States)

    Eisenman, R; Girdner, E J; Burroughs, R G; Routman, M

    1993-01-01

    The attitudes of 211 students at a university in Mississippi were investigated both before and after seeing the Public Broadcasting Film Who Is David Duke? The film provided evidence of Duke's current racism, anti-Semitism, and pro-Nazi leanings. In a previous study with university students in Louisiana, the majority did not change their attitudes after watching the film (Eisenman, 1993). However, in the present study, students' attitudes showed change in an anti-Duke direction. The findings are discussed and reasons given for the differences between the two samples, and for the popularity of Duke, a former leader of the Ku Klux Klan.

  2. The Will to Touch: David Copperfield’s Hand

    Directory of Open Access Journals (Sweden)

    Pamela K. Gilbert

    2014-10-01

    Full Text Available In the nineteenth century, touch was considered to be a more privileged sense than has been generally noted, and the hand was pre-eminently the site of active touching. The hand comes newly to rival the face in descriptive significance in mid-nineteenth-century fiction, and reflects contemporary notions of the role of touch in the exercise of the will and the development of the sensorium. This article explores medical and philosophical understandings of embodied touch within the period, and examines why the hand emerged as a focal point for scientific, poetic, and popular discussion. Such scientists as Charles Bell, Herbert Spencer, and Alexander Bain tend to work within two paradigms: the hand as a site of sensory input that forms a conduit between inner and outer worlds, and the hand as an instrument of the will. The article explores Dickens's use of these ideas about touch and development in his 1850 'Bildungsroman', 'David Copperfield'. David struggles to establish his proper status as a middle-class male, in part by learning to use his hands to impose his own will and to resist the dominance of inappropriate others through touch.

  3. David Rosenthal’s Tirant lo Blanc turns 30

    Directory of Open Access Journals (Sweden)

    Jan Reinhart

    2014-12-01

    Full Text Available The groundbreaking English language translation of Tirant lo Blanc by New York poet and academic David Rosenthal remains dominant three decades after its initial, and celebrated, release. Rosenthal’s controversially fluid and concise rendering of the Valencian classic survived a serious challenge 20 years ago by a more literal version from a well-meaning amateur translator and journeyman academic backed by a leading U.S.-based Catalan scholar. The article reviews the controversy and compares the two versions, adding comments from some of the key critics. La traducció capdavantera a l’anglés del Tirant lo Blanc, feta pel poeta i erudit de Nova York, David Rosenthal, continua mantenint la seua importància, tres dècades després de publicar-se. La polèmica versió dúctil i concisa de Rosenthal del clàssic valencià, ha sobreviscut el desafiament seriós, de fa vint anys, de la versió més literal d’un benintencionat traductor amateur i acadèmci oficial, recolzat per un destacat erudit català establert als Estats Units. L’article revisa la polèmica i compara les dues versions, tot afegint els comentaris d’alguns dels crítics més importants.

  4. Association of Ambulatory Blood Pressure Monitoring parameters with the Framingham Stroke Risk Profile.

    Science.gov (United States)

    Tsivgoulis, Georgios; Pikilidou, Maria; Katsanos, Aristeidis H; Stamatelopoulos, Kimon; Michas, Fotios; Lykka, Aikaterini; Zompola, Christina; Filippatou, Angeliki; Boviatsis, Efstathios; Voumvourakis, Konstantinos; Zakopoulos, Nikolaos; Manios, Efstathios

    2017-09-15

    The Framingham Stroke Risk Profile (FSRP) is a novel and reliable tool for estimating the 10-year probability for incident stroke in stroke-free individuals, while the predictive value of ambulatory blood pressure monitoring (ABPM) for first-ever and recurrent stroke has been well established. We sought to evaluate cross-sectionally the association of ABPM parameters with FSRP score in a large sample of 2343 consecutive stroke-free individuals (mean age: 56.0±12.9, 49.1% male) who underwent 24-hour ABPM. True hypertensives showed significantly higher FSRP (11.2±5.0) compared to the normotensives (8.2±5.0, pbest fitting model for predicting FSRP (R 2 =24.6%) on multiple linear regression analyses after adjustment for vascular risk factors not included in FSRP comprised the following parameters in descending order: 24-hour PP (β=0.349, p<0.001), daytime SBP variability (β=0.124, p<0.001), 24-hour HR variability (β=-0.091, p<0.001), mean 24-hour HR (β=-0.107, p<0.001), BMI (β=0.081, p<0.001) and dipping percentage (β=-0.063, p=0.001). 24-hour PP and daytime SBP variability are the two ABPM parameters that were more strongly associated with FSRP-score. Reverse dippers had the highest FSRP among all dipping status profiles. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Relationship between framingham risk score and coronary artery calcium score in asymptomatic Korean individuals

    International Nuclear Information System (INIS)

    Heo, So Young; Park, Noh Hyuck; Park, Chan Sub; Seong, Su Ok

    2016-01-01

    We explored the association between Framingham risk score (FRS) and coronary artery calcium score (CACS) in asymptomatic Korean individuals. We retrospectively analyzed 2216 participants who underwent routine health screening and CACS using the 64-slice multidetector computed tomography between January 2010 and June 2014. Relationship between CACS and FRS, and factors associated with discrepancy between CACS and FRS were analyzed. CACS and FRS were positively correlated (p < 0.0001). However, in 3.7% of participants with low coronary event risk and high CACS, age, male gender, smoker, hypertension, total cholesterol, diabetes mellitus, and body mass index (BMI; ≥ 35) were associated with the discrepancy. In the diagnostic prediction model for discrepancy, the receiver operating characteristic curve including factors associated with FRS, diastolic blood pressure (≥ 75 mm Hg), diabetes mellitus, and BMI (≥ 35) showed that the area under the curve was 0.854 (95% confidence interval, 0.819–0.890), indicating good sensitivity. Diabetes mellitus or obesity (BMI ≥ 35) compensate for the weakness of FRS and may be potential indicators for application of CACS in asymptomatic Koreans with low coronary event risk

  6. Relation of smoking status to a panel of inflammatory markers: the framingham offspring.

    Science.gov (United States)

    Levitzky, Yamini S; Guo, Chao-Yu; Rong, Jian; Larson, Martin G; Walter, Robert E; Keaney, John F; Sutherland, Patrice A; Vasan, Aditi; Lipinska, Izabella; Evans, Jane C; Benjamin, Emelia J

    2008-11-01

    We sought to investigate the hypothesis that smoking is accompanied by systemic inflammation. We examined the relation of smoking to 11 systemic inflammatory markers in Framingham Study participants (n=2944, mean age 60 years, 55% women, 12% ethnic minorities) examined from 1998-2001. The cohort was divided into never (n=1149), former (n=1424), and current smokers with last cigarette >6h (n=134) or < or =6h (n=237) prior to phlebotomy. In multivariable-adjusted models there were significant overall between-smoking group differences (defined as p<0.0045 to account for multiple testing) for every inflammatory marker tested, except for serum CD40 ligand (CD40L), myeloperoxidase (MPO) and tumor necrosis factor receptor-2 (TNFR2). With multivariable-adjustment, pair-wise comparisons with never smokers revealed that former smokers had significantly lower concentrations of plasma CD40L (p<0.0001) and higher concentrations of (CRP) C-reactive protein (p=0.002). As opposed to never smokers, those with acute cigarette smoke exposure (< or =6h) had significantly higher concentrations of all markers (p<0.0001) except serum CD40L, MPO, and TNFR2; plasma CD40L were significantly lower. Compared with never smokers, cigarette smokers have significantly elevated concentrations of most circulating inflammatory markers, consistent with the hypothesis that smoking is associated with a systemic inflammatory state.

  7. Alimentary habits, physical activity, and Framingham global risk score in metabolic syndrome.

    Science.gov (United States)

    Soares, Thays Soliman; Piovesan, Carla Haas; Gustavo, Andréia da Silva; Macagnan, Fabrício Edler; Bodanese, Luiz Carlos; Feoli, Ana Maria Pandolfo

    2014-04-01

    Metabolic syndrome is a complex disorder represented by a set of cardiovascular risk factors. A healthy lifestyle is strongly related to improve Quality of Life and interfere positively in the control of risk factors presented in this condition. To evaluate the effect of a program of lifestyle modification on the Framingham General Cardiovascular Risk Profile in subjects diagnosed with metabolic syndrome. A sub-analysis study of a randomized clinical trial controlled blind that lasted three months. Participants were randomized into four groups: dietary intervention + placebo (DIP), dietary intervention + supplementation of omega 3 (fish oil 3 g/day) (DIS3), dietary intervention + placebo + physical activity (DIPE) and dietary intervention + physical activity + supplementation of omega 3 (DIS3PE). The general cardiovascular risk profile of each individual was calculated before and after the intervention. The study included 70 subjects. Evaluating the score between the pre and post intervention yielded a significant value (p study emphasizes the importance of lifestyle modification in the prevention and treatment of cardiovascular diseases.

  8. Surficial geologic map of the Framingham quadrangle, Middlesex and Worcester Counties, Massachusetts

    Science.gov (United States)

    Nelson, Arthur E.

    1974-01-01

    The Framingham quadrangle covers about 55 square miles and is centered approximately 18 miles west of Boston.  Even though the major topographic features are controlled by the lithology and structure of the bedrock, glacial features, such as drumlins, kames and kettles, kame terraces, eskers, gently sloping deltas, and flat-lying lake-bottom deposits, have modified the preglacial topography.  Some bedrock plucking occurred, especially on the south or southeast sides of some hills, and some valleys probably were deepened.  A thin veneer of till overlies much of the bedrock and is most extensive in the hills in the western half of the map area.  These deposits, which are mostly gently sloping kame deltas or flat-lying lake-bottom deposits, were laid down in or graded to glacial Lakes Charles (Clapp, 1904, p. 198) and Sudbury (Goldthwait, 1905, p. 274), which formed during deglaciation when melt waters were temporarily impounded.  Some glacial-lake deposits were laid down in three smaller higher level lakes in the western part of the quadrangle.

  9. Relationship between framingham risk score and coronary artery calcium score in asymptomatic Korean individuals

    Energy Technology Data Exchange (ETDEWEB)

    Heo, So Young; Park, Noh Hyuck; Park, Chan Sub; Seong, Su Ok [Dept. of Radiology, Myongji Hospital, Seonam University College of Medicine, Goyang (Korea, Republic of)

    2016-02-15

    We explored the association between Framingham risk score (FRS) and coronary artery calcium score (CACS) in asymptomatic Korean individuals. We retrospectively analyzed 2216 participants who underwent routine health screening and CACS using the 64-slice multidetector computed tomography between January 2010 and June 2014. Relationship between CACS and FRS, and factors associated with discrepancy between CACS and FRS were analyzed. CACS and FRS were positively correlated (p < 0.0001). However, in 3.7% of participants with low coronary event risk and high CACS, age, male gender, smoker, hypertension, total cholesterol, diabetes mellitus, and body mass index (BMI; ≥ 35) were associated with the discrepancy. In the diagnostic prediction model for discrepancy, the receiver operating characteristic curve including factors associated with FRS, diastolic blood pressure (≥ 75 mm Hg), diabetes mellitus, and BMI (≥ 35) showed that the area under the curve was 0.854 (95% confidence interval, 0.819–0.890), indicating good sensitivity. Diabetes mellitus or obesity (BMI ≥ 35) compensate for the weakness of FRS and may be potential indicators for application of CACS in asymptomatic Koreans with low coronary event risk.

  10. Alimentary Habits, Physical Activity, and Framingham Global Risk Score in Metabolic Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Thays Soliman; Piovesan, Carla Haas; Gustavo, Andréia da Silva; Macagnan, Fabrício Edler; Bodanese, Luiz Carlos; Feoli, Ana Maria Pandolfo, E-mail: anamariafeoli@hotmail.com [Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS (Brazil)

    2014-04-15

    Metabolic syndrome is a complex disorder represented by a set of cardiovascular risk factors. A healthy lifestyle is strongly related to improve Quality of Life and interfere positively in the control of risk factors presented in this condition. To evaluate the effect of a program of lifestyle modification on the Framingham General Cardiovascular Risk Profile in subjects diagnosed with metabolic syndrome. A sub-analysis study of a randomized clinical trial controlled blind that lasted three months. Participants were randomized into four groups: dietary intervention + placebo (DIP), dietary intervention + supplementation of omega 3 (fish oil 3 g/day) (DIS3), dietary intervention + placebo + physical activity (DIPE) and dietary intervention + physical activity + supplementation of omega 3 (DIS3PE). The general cardiovascular risk profile of each individual was calculated before and after the intervention. The study included 70 subjects. Evaluating the score between the pre and post intervention yielded a significant value (p < 0.001). We obtained a reduction for intermediate risk in 25.7% of subjects. After intervention, there was a significant reduction (p < 0.01) on cardiovascular age, this being more significant in groups DIP (5.2%) and DIPE (5.3%). Proposed interventions produced beneficial effects for reducing cardiovascular risk score. This study emphasizes the importance of lifestyle modification in the prevention and treatment of cardiovascular diseases.

  11. Longtime napping is associated with cardiovascular risk estimation according to Framingham risk score in postmenopausal women.

    Science.gov (United States)

    Li, Feng; Sun, Kan; Lin, Diaozhu; Qi, Yiqin; Li, Yan; Yan, Li; Ren, Meng

    2016-09-01

    Menopause can affect the physiological timing system, which could result in circadian rhythm changes and development of napping habits. Whether longtime napping in postmenopausal women is associated with cardiovascular disease is, however, still debated. The present study aims to investigate this association. We conducted a population-based study in 4,616 postmenopausal Chinese women. Information on sleep duration was self-reported. The Framingham General Cardiovascular Risk Score was calculated and used to identify participants at high risk of coronary heart disease (CHD). Increased daytime napping hours were positively associated with cardiovascular disease risk factors in postmenopausal women, such as age, waist circumference, systolic blood pressure, triglycerides, fasting glucose, postload glucose, and hemoglobin A1C (all P for trend napping hours, and was 3.7%, 4.3%, and 6.9% in the no daytime napping group, the 0.1 to 1 hour group, and the more than 1 hour group, respectively (P for trend = 0.005). Compared with the no daytime napping group, postmenopausal women with daytime napping more than 1 hour had higher risk of CHD in both univariate (odds ratio 1.94, 95% CI, 1.29-2.95) and multivariate (odds ratio 1.61, 95% CI, 1.03-2.52) logistic regression analyses. No statistically significant association was detected between night sleeping hours and high risk of CHD in postmenopausal participants. Daytime napping is positively associated with estimated 10-year CHD risk in postmenopausal Chinese women.

  12. Alimentary Habits, Physical Activity, and Framingham Global Risk Score in Metabolic Syndrome

    International Nuclear Information System (INIS)

    Soares, Thays Soliman; Piovesan, Carla Haas; Gustavo, Andréia da Silva; Macagnan, Fabrício Edler; Bodanese, Luiz Carlos; Feoli, Ana Maria Pandolfo

    2014-01-01

    Metabolic syndrome is a complex disorder represented by a set of cardiovascular risk factors. A healthy lifestyle is strongly related to improve Quality of Life and interfere positively in the control of risk factors presented in this condition. To evaluate the effect of a program of lifestyle modification on the Framingham General Cardiovascular Risk Profile in subjects diagnosed with metabolic syndrome. A sub-analysis study of a randomized clinical trial controlled blind that lasted three months. Participants were randomized into four groups: dietary intervention + placebo (DIP), dietary intervention + supplementation of omega 3 (fish oil 3 g/day) (DIS3), dietary intervention + placebo + physical activity (DIPE) and dietary intervention + physical activity + supplementation of omega 3 (DIS3PE). The general cardiovascular risk profile of each individual was calculated before and after the intervention. The study included 70 subjects. Evaluating the score between the pre and post intervention yielded a significant value (p < 0.001). We obtained a reduction for intermediate risk in 25.7% of subjects. After intervention, there was a significant reduction (p < 0.01) on cardiovascular age, this being more significant in groups DIP (5.2%) and DIPE (5.3%). Proposed interventions produced beneficial effects for reducing cardiovascular risk score. This study emphasizes the importance of lifestyle modification in the prevention and treatment of cardiovascular diseases

  13. Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort.

    Science.gov (United States)

    DeChristopher, Luanne R; Tucker, Katherine L

    2018-05-01

    There is growing evidence that intakes of high-fructose corn syrup (HFCS), HFCS-sweetened soda, fruit drinks and apple juice - a high-fructose 100 % juice - are associated with asthma, possibly because of the high fructose:glucose ratios and underlying fructose malabsorption, which may contribute to enteral formation of pro-inflammatory advanced glycation end products, which bind receptors that are mediators of asthma. Cox proportional hazards models were used to assess associations between intakes of these beverages and asthma risk, with data from the Framingham Offspring Cohort. Diet soda and orange juice - a 100 % juice with a 1:1 fructose:glucose ratio - were included for comparison. Increasing intake of any combination of HFCS-sweetened soda, fruit drinks and apple juice was significantly associated with progressively higher asthma risk, plateauing at 5-7 times/week v. never/seldom, independent of potential confounders (hazard ratio 1·91, Pfructose:glucose ratios, and fructose malabsorption. Recommendations to reduce consumption may be inadequate to address asthma risk, as associations are evident even with moderate intake of these beverages, including apple juice - a 100 % juice. The juice reductions in the US Special Supplemental Nutrition Program for Women, Infants, and Children in 2009, and the plateauing/decreasing asthma prevalence (2010-2013), particularly among non-Hispanic black children, may be related. Further research regarding the consequences of fructose malabsorption is needed.

  14. Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study.

    Science.gov (United States)

    Wang, Thomas J; Wollert, Kai C; Larson, Martin G; Coglianese, Erin; McCabe, Elizabeth L; Cheng, Susan; Ho, Jennifer E; Fradley, Michael G; Ghorbani, Anahita; Xanthakis, Vanessa; Kempf, Tibor; Benjamin, Emelia J; Levy, Daniel; Vasan, Ramachandran S; Januzzi, James L

    2012-09-25

    Biomarkers for predicting cardiovascular events in community-based populations have not consistently added information to standard risk factors. A limitation of many previously studied biomarkers is their lack of cardiovascular specificity. To determine the prognostic value of 3 novel biomarkers induced by cardiovascular stress, we measured soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I in 3428 participants (mean age, 59 years; 53% women) in the Framingham Heart Study. We performed multivariable-adjusted proportional hazards models to assess the individual and combined ability of the biomarkers to predict adverse outcomes. We also constructed a "multimarker" score composed of the 3 biomarkers in addition to B-type natriuretic peptide and high-sensitivity C-reactive protein. During a mean follow-up of 11.3 years, there were 488 deaths, 336 major cardiovascular events, 162 heart failure events, and 142 coronary events. In multivariable-adjusted models, the 3 new biomarkers were associated with each end point (Pstatistic (P=0.005 or lower) and net reclassification improvement (P=0.001 or lower). Multiple biomarkers of cardiovascular stress are detectable in ambulatory individuals and add prognostic value to standard risk factors for predicting death, overall cardiovascular events, and heart failure.

  15. David Hume filósofo e historiador

    Directory of Open Access Journals (Sweden)

    Sara Albieri

    2004-12-01

    Full Text Available Among all the great philosophers, David Hume has the rare merit of joining to a properly philosophical work an equally important output as historian. According to him, the interpretation of history by means of the general principles of political theory must not be guided by ethical or normative considerations, as when judging historic events according to what things ought to be, for instance, in view of the best government, but it should be restricted to explain the exercise of power in the different times, just as it can be established by the testimony of the sources. Only this methodological attitude allows us to avoid the partisan interpretations that try to justify the present by the past, instead of investigating it to corroborate the most appropriate explanation.

  16. Masculinity and violence in David Fincher’s "Fight Club"

    Directory of Open Access Journals (Sweden)

    Leire Ituarte Pérez

    2017-12-01

    Full Text Available In this article we address a hermeneutic approach to David Fincher’s Fight Club. Inspired by some of the methodological principles of Psychoanalysis and Queer Theory the study tries to thresh the details of the representation of Masculinity in the film. Departing from the hypothesis that such representation in the film is closely linked to the masculine castration anxiety, the essay traces the recurrent and more or less parodic, more or less subliminal allusions to emasculation as well as the fetishistic compensatory strategies displayed. The analysis concludes that the overwhelming mise en scène of the masculine Oedipal scenario in the film pursues to underpin an hegemonic discourse of Masculinity threatened by the taboo of Homosexuality. Hence, the prominent erotisization of masculine masochism reveals itself, in all its ambivalence, as a performative strategy to institutionalise a heteronormative sexual regime.

  17. Infinite potential the life and times of David Bohm

    CERN Document Server

    Peat, David

    1997-01-01

    Throughout his life, David Bohm felt himself to be different, and this was reflected in his lifestyle and in his physics. His life was one of unfulfilled searching. If one compares mainstream physics to the church, with a solid hierarchy of cardinals, archbishops and bishops, Bohm was an ascetic hermit who would occasionally come in from the wilderness with a compelling message, only to disappear again. Bohmian quantum mechanics is not part of mainstream physics, but for those who do cross over, like John Bell, the commitment can be rewarding. In the post-war 'Un-American Activities' purge, Bohm lost a prestigious job at Princeton and t emporarily his US citizenship, and his nomadic career took him to Brazil, Israel and Bristol before he finally settled in London's Birkbeck College. A sensitive-written book about a gifted, unusual and sometimes provocative figure. The interaction between Bohm and Oppenheimer is especially interesting, while Bohm's later life was bizarre.

  18. David Falk: Algunas cuestiones abiertas para el marketing deportivo. [David Falk: Some open questions for the sports marketing arena].

    Directory of Open Access Journals (Sweden)

    José A. Martínez

    2015-04-01

    Full Text Available David Falk, el que fuera el representante del jugador de baloncesto Michael Jordan, es una figura de referencia para el marketing deportivo. Falk contribuyó decisivamente a revitalizar el marketing deportivo, ayudó a construir lo que probablemente sea la relación comercial más importante del deporte (Jordan-Nike, y llevó hasta el extremo la filosofía de que en la negociación lo importante es que tu cliente llegue a conseguir el máximo dinero posible, más allá de que ese sea su valor de mercado o que el propio mercado pueda admitir esa inflación. En este artículo se repasan algunos de los hechos más destacados de su vida profesional y, desde una perspectiva crítica, se relacionan con varias cuestiones abiertas que el mundo académico y profesional del deporte continúa discutiendo. Abstract David Falk, former agent of the basketball player Michael Jordan, is a figure of reference for sports marketing. Falk was instrumental in revitalizing the sports marketing. He helped to build what is probably the most important relationship in sport business (Jordan-Nike, and strongly defended a radical philosophy of negotiation, where the most important is the maximization of client gains, regardless their true market value or if the market can admit such inflation. This article reviews some of the highlights of his career facts and, from a critical perspective, discusses several open issues related to the academic and professional world of sports. To achieve this aim, several recent contributions to the marketing and sports literature are commented.

  19. Accuracy and reproducibility of the DAVID SLS-2 scanner in three-dimensional facial imaging

    DEFF Research Database (Denmark)

    Secher, Jesper Jared; Darvann, Tron Andre; Pinholt, Else Marie

    2017-01-01

    PURPOSE: A prospective study was performed to test the accuracy and reproducibility of the DAVID-SLS-2 scanner (SLS-2) [DAVID Vision Systems GmbH], compared to the validated 3dMDtrio scanner (3dMD) [3dMD, LLC, Atlanta, GA, USA]. MATERIALS AND METHODS: The accuracy of the SLS-2 was determined thro...

  20. Discussion of David Thissen's Bad Questions: An Essay Involving Item Response Theory

    Science.gov (United States)

    Wainer, Howard

    2016-01-01

    The usual role of a discussant is to clarify and correct the paper being discussed, but in this case, the author, Howard Wainer, generally agrees with everything David Thissen says in his essay, "Bad Questions: An Essay Involving Item Response Theory." This essay expands on David Thissen's statement that there are typically two principal…

  1. A Cabinet of Mathematical Curiosities at Teachers College: David Eugene Smith's Collection

    Science.gov (United States)

    Murray, Diane R.

    2012-01-01

    This dissertation is a history of David Eugene Smith's collection of historical books, manuscripts, portraits, and instruments related to mathematics. The study analyzes surviving documents, images, objects, college announcements and catalogs, and secondary sources related to Smith's collection. David Eugene Smith (1860-1944) travelled…

  2. Report from the David Peikoff Chair of Deafness Studies: January 1989 through August 1991.

    Science.gov (United States)

    Schein, Jerome D.

    1991-01-01

    Following a brief biography of David Peikoff, this paper describes the first occupant of the David Peikoff Chair of Deafness Studies, Jerome D. Schein. The chair's research agenda on mediated communication and demography of impaired hearing are described, as well as organization of an international conference, public addresses, and technical…

  3. Association between duration of reproductive lifespan and Framingham risk score in postmenopausal women.

    Science.gov (United States)

    Kim, Soo Hyun; Sim, Mu Yul; Park, Sat Byul

    2015-12-01

    The benefit of estrogen therapy in postmenopausal women is still uncertain. Based upon extensive observational data, it was believed that estrogen was cardioprotective. The relationship between the period of exposure to endogenous estrogens and the risk of cardiovascular disease (CVD) has not been studied in Korean women. To assess associations between reproductive lifespan and CVD by using the Framingham risk score (FRS) in postmenopausal Korean women. This cross-sectional, population-based study used data from the Korea National Health and Nutrition Examination Survey (KNHANES) for the five years 2008-2012,after adjustment for relevant variables using complex sample analysis and data weighting. Among 25,534 women, 1973 women were enrolled, after excluding those 80 years of age (n=6194), those with diabetes, CVD or cancer (n=491), those with unrecorded physical measurements (n=7335), those with menarche age ≤8 years or ≥20 years (n=6194), and premenopausal women (n=3347). The FRS tended to show a significant negative correlation with the reproductive lifespan (preproductive lifespan and FRS (adjusted relative risk [RR] for reproductive years [shortest lifespan group] compared with 28-33 reproductive years [moderate lifespan group], 1.2, p33 reproductive years [longest lifespan group] compared with 28-33 reproductive years [moderate lifespan group], -0.42, p=0.011). A longer reproductive lifespan is associated with a lower estimated risk of CVD in the next 10 years in postmenopausal women. This result suggests that estrogen has a long-term protective effect against CVD. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  4. Obesity phenotype and coronary heart disease risk as estimated by the Framingham risk score.

    Science.gov (United States)

    Park, Yong Soon; Kim, Jun-Su

    2012-03-01

    There are conflicting data as to whether general or abdominal obesity is a better predictor of cardiovascular risk. This cross-sectional study involved 4,573 subjects aged 30 to 74 yr who participated in the Fourth Korea National Health and Nutrition Examination Survey conducted in 2008. Obesity phenotype was classified by means of body mass index (BMI) and waist circumference (WC), and participants were categorized into 4 groups. Individuals' 10-yr risk of coronary heart diseases (CHD) was determined from the Framingham risk score. Subjects with obese WC had a higher proportion of high risk for CHD compared to the normal WC group, irrespective of BMI level. Relative to subjects with normal BMI/normal WC, the adjusted odds ratios (ORs) of normal BMI/obese WC group (OR 2.93 [1.70, 5.04] and OR 3.10 [1.49, 6.46]) for CHD risk in male were higher than obese BMI/obese WC group (OR 1.91 [1.40, 2.61] and OR 1.70 [1.16, 2.47]), whereas the adjusted ORs of obese BMI/obese WC group (OR 1.94 [1.24, 3.04] and OR 3.92 [1.75, 8.78]) were higher than the others in female. Subjects with obese BMI/normal WC were not significantly associated with 10-yr CHD risk in men (P = 0.449 and P = 0.067) and women (P = 0.702 and P = 0.658). WC is associated with increased CHD risk regardless of the level of BMI. Men with normal BMI and obese WC tend to be associated with CHD risk than those with obese BMI and obese WC.

  5. Integrated genetic and epigenetic prediction of coronary heart disease in the Framingham Heart Study.

    Directory of Open Access Journals (Sweden)

    Meeshanthini V Dogan

    Full Text Available An improved method for detecting coronary heart disease (CHD could have substantial clinical impact. Building on the idea that systemic effects of CHD risk factors are a conglomeration of genetic and environmental factors, we use machine learning techniques and integrate genetic, epigenetic and phenotype data from the Framingham Heart Study to build and test a Random Forest classification model for symptomatic CHD. Our classifier was trained on n = 1,545 individuals and consisted of four DNA methylation sites, two SNPs, age and gender. The methylation sites and SNPs were selected during the training phase. The final trained model was then tested on n = 142 individuals. The test data comprised of individuals removed based on relatedness to those in the training dataset. This integrated classifier was capable of classifying symptomatic CHD status of those in the test set with an accuracy, sensitivity and specificity of 78%, 0.75 and 0.80, respectively. In contrast, a model using only conventional CHD risk factors as predictors had an accuracy and sensitivity of only 65% and 0.42, respectively, but with a specificity of 0.89 in the test set. Regression analyses of the methylation signatures illustrate our ability to map these signatures to known risk factors in CHD pathogenesis. These results demonstrate the capability of an integrated approach to effectively model symptomatic CHD status. These results also suggest that future studies of biomaterial collected from longitudinally informative cohorts that are specifically characterized for cardiac disease at follow-up could lead to the introduction of sensitive, readily employable integrated genetic-epigenetic algorithms for predicting onset of future symptomatic CHD.

  6. Evolution of Mitral Valve Prolapse: Insights From the Framingham Heart Study.

    Science.gov (United States)

    Delling, Francesca N; Rong, Jian; Larson, Martin G; Lehman, Birgitta; Fuller, Deborah; Osypiuk, Ewa; Stantchev, Plamen; Hackman, Brianne; Manning, Warren J; Benjamin, Emelia J; Levine, Robert A; Vasan, Ramachandran S

    2016-04-26

    Longitudinal studies of mitral valve prolapse (MVP) progression among unselected individuals in the community, including those with nondiagnostic MVP morphologies (NDMs), are lacking. We measured longitudinal changes in annular diameter, leaflet displacement, thickness, anterior/posterior leaflet projections onto the annulus, coaptation height, and mitral regurgitation jet height in 261 Framingham Offspring participants at examination 5 who had available follow-up imaging 3 to 16 years later. Study participants included MVP (n=63); NDMs, minimal systolic displacement (n=50) and the abnormal anterior coaptation phenotype (n=10, with coaptation height >40% of the annulus similar to posterior MVP); plus 138 healthy referents without MVP or NDMs. At follow-up, individuals with MVP (52% women, 57±11 years) had greater increases of leaflet displacement, thickness, and jet height than referents (all PMVP (17%) had moderate or more severe mitral regurgitation (jet height ≥5 mm) and 5 others (8%) underwent mitral valve repair. Of the individuals with NDM, 8 (80%) participants with abnormal anterior coaptation progressed to posterior MVP; 17 (34%) subjects with minimal systolic displacement were reclassified as either posterior MVP (12) or abnormal anterior coaptation (5). In comparison with the 33 participants with minimal systolic displacement who did not progress, the 17 who progressed had greater leaflet displacement, thickness, coaptation height, and mitral regurgitation jet height (all PMVP, highlighting the clinical significance of mild MVP expression. MVP progresses to significant mitral regurgitation over a period of 3 to 16 years in one-fourth of individuals in the community. Changes in mitral leaflet morphology are associated with both NDM and MVP progression. © 2016 American Heart Association, Inc.

  7. Mild expression of mitral valve prolapse in the Framingham offspring: expanding the phenotypic spectrum.

    Science.gov (United States)

    Delling, Francesca N; Gona, Philimon; Larson, Martin G; Lehman, Birgitta; Manning, Warren J; Levine, Robert A; Benjamin, Emelia J; Vasan, Ramachandran S

    2014-01-01

    Mitral valve (MV) prolapse (MVP) is a common disorder associated with mitral regurgitation, endocarditis, heart failure, and sudden death. Nondiagnostic morphologies have been described in the familial context and may represent early expression of MVP in those genetically predisposed. The aim of this study was to explore the spectrum of MVP abnormalities in the community and compare their clinical and echocardiographic features. We measured annular diameter MV leaflet displacement, thickness, anterior and posterior leaflet projections onto the annulus, MV leaflet coaptation height (posterior MV leaflet projection/annular diameter), and MR jet height in 296 individuals of the Framingham Offspring Study with MVP (n = 77), the "abnormal anterior coaptation" (AAC) phenotype (n = 11) or "minimal systolic displacement" (MSD) (n = 57), and 151 age-matched and sex-matched referents with no MVP or its nondiagnostic forms. AAC did not meet diagnostic displacement criteria but resembled MVP with regard to annular diameter and leaflet thickness (P > .05 for both). AAC was similar to posterior MVP with regard to posterior leaflet asymmetry and an anteriorly shifted coaptation (P = .91). Compared to patients with MSD and referents, patients with AAC had greater leaflet coaptation height, thickness, and annular diameter (P MVP, but the coaptation point was more posterior (coaptation height = 31% vs. 42%, P MVP had jet height ≥ 2 mm (mild or greater MR) compared with the other participants (44% vs. 16%, P MVP. AAC and MSD may thus represent early expressions of MVP. Longitudinal studies are warranted to elucidate the natural history of these phenotypes. Published by Mosby, Inc.

  8. The Evolution of Mitral Valve Prolapse: Insights from the Framingham Heart Study

    Science.gov (United States)

    Delling, Francesca N.; Rong, Jian; Larson, Martin G.; Lehman, Birgitta; Fuller, Deborah; Osypiuk, Ewa; Stantchev, Plamen; Hackman, Brianne; Manning, Warren J.; Benjamin, Emelia J.; Levine, Robert A.; Vasan, Ramachandran S.

    2016-01-01

    Background Longitudinal studies of mitral valve prolapse (MVP) progression among unselected individuals in the community, including those with non-diagnostic MVP morphologies (NDM), are lacking. Methods and Results We measured longitudinal changes in annular diameter, leaflet displacement, thickness, anterior/posterior leaflet projections onto the annulus, coaptation height, and mitral regurgitation (MR) jet height in 261 Framingham Offspring participants at Examination 5 who had available follow-up imaging 3 to 16 years later. Study participants included MVP (N=63), NDM - ‘minimal systolic displacement’ or MSD (N=50) and the ‘abnormal anterior coaptation’ (AAC) phenotype (N=10, with coaptation height >40% of the annulus similar to posterior MVP), plus 138 healthy referents without MVP or NDM. At follow-up, individuals with MVP (52% women, 57±11 years) had greater increases of leaflet displacement, thickness, and jet height compared with referents (all pMVP (17%) had ≥ moderate MR (jet height ≥5 mm) and 5 others (8%) underwent mitral valve repair. Of the individuals with NDM, 8 (80%) AACs progressed to posterior MVP; 17 (34%) MSDs were reclassified as either posterior MVP (12) or AAC (5). Compared with the 33 MSDs who did not progress, the 17 who progressed had greater leaflet displacement, thickness, coaptation height, and MR jet height (all pMVP, highlighting the clinical significance of mild MVP expression. MVP progresses to significant MR over a period of 3 to 16 years in a quarter of individuals in the community. Changes in mitral leaflet morphology are associated with both NDM and MVP progression. PMID:27006478

  9. Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study.

    Science.gov (United States)

    Li, Wenyuan; Wilker, Elissa H; Dorans, Kirsten S; Rice, Mary B; Schwartz, Joel; Coull, Brent A; Koutrakis, Petros; Gold, Diane R; Keaney, John F; Lin, Honghuang; Vasan, Ramachandran S; Benjamin, Emelia J; Mittleman, Murray A

    2016-04-28

    Short-term exposure to elevated air pollution has been associated with higher risk of acute cardiovascular diseases, with systemic oxidative stress induced by air pollution hypothesized as an important underlying mechanism. However, few community-based studies have assessed this association. Two thousand thirty-five Framingham Offspring Cohort participants living within 50 km of the Harvard Boston Supersite who were not current smokers were included. We assessed circulating biomarkers of oxidative stress including blood myeloperoxidase at the seventh examination (1998-2001) and urinary creatinine-indexed 8-epi-prostaglandin F2α (8-epi-PGF2α) at the seventh and eighth (2005-2008) examinations. We measured fine particulate matter (PM2.5), black carbon, sulfate, nitrogen oxides, and ozone at the Supersite and calculated 1-, 2-, 3-, 5-, and 7-day moving averages of each pollutant. Measured myeloperoxidase and 8-epi-PGF2α were loge transformed. We used linear regression models and linear mixed-effects models with random intercepts for myeloperoxidase and indexed 8-epi-PGF2α, respectively. Models were adjusted for demographic variables, individual- and area-level measures of socioeconomic position, clinical and lifestyle factors, weather, and temporal trend. We found positive associations of PM2.5 and black carbon with myeloperoxidase across multiple moving averages. Additionally, 2- to 7-day moving averages of PM2.5 and sulfate were consistently positively associated with 8-epi-PGF2α. Stronger positive associations of black carbon and sulfate with myeloperoxidase were observed among participants with diabetes than in those without. Our community-based investigation supports an association of select markers of ambient air pollution with circulating biomarkers of oxidative stress. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  10. Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study.

    Science.gov (United States)

    Mangano, Kelsey M; Sahni, Shivani; Kiel, Douglas P; Tucker, Katherine L; Dufour, Alyssa B; Hannan, Marian T

    2017-03-01

    Background: Above-average dietary protein, as a single nutrient, improves musculoskeletal health. Evaluating the link between dietary protein and musculoskeletal health from a whole-diet perspective is important, as dietary guidelines focus on dietary patterns. Objective: We examined the prospective association of novel dietary protein food clusters (derived from established dietary pattern techniques) with appendicular lean mass (ALM), quadriceps strength (QS), and bone mineral density (BMD) in 2986 men and women, aged 19-72 y, from the Framingham Third Generation Study. Design: Total protein intake was estimated by food-frequency questionnaire in 2002-2005. A cluster analysis was used to classify participants into mutually exclusive groups, which were determined by using the percentage of contribution of food intake to overall protein intake. General linear modeling was used to 1 ) estimate the association between protein intake (grams per day) and BMD, ALM, appendicular lean mass normalized for height (ALM/ht 2 ), and QS (2008-2011) and to 2 ) calculate adjusted least-squares mean outcomes across quartiles of protein (grams per day) and protein food clusters. Results: The mean ± SD age of subjects was 40 ± 9 y; 82% of participants met the Recommended Daily Allowance (0.8 g · kg body weight -1 · d -1 ). The following 6 dietary protein food clusters were identified: fast food and full-fat dairy, fish, red meat, chicken, low-fat milk, and legumes. BMD was not different across quartiles of protein intake ( P -trend range = 0.32-0.82); but significant positive trends were observed for ALM, ALM/ht 2 ( P dietary protein is associated with ALM and QS but not with BMD. In this study, dietary protein food patterns do not provide further insight into beneficial protein effects on muscle outcomes. © 2017 American Society for Nutrition.

  11. Dietary patterns and the metabolic syndrome in obese and non-obese Framingham women.

    Science.gov (United States)

    Sonnenberg, Lillian; Pencina, Michael; Kimokoti, Ruth; Quatromoni, Paula; Nam, Byung-Ho; D'Agostino, Ralph; Meigs, James B; Ordovas, Jose; Cobain, Mark; Millen, Barbara

    2005-01-01

    To examine the relationship between habitual dietary patterns and the metabolic syndrome (MetS) in women and to identify foci for preventive nutrition interventions. Dietary patterns, nutrient intake, cardiovascular disease (CVD), and MetS risk factors were characterized in 1615 Framingham Offspring-Spouse Study (FOS) women. Dietary pattern subgroups were compared for MetS prevalence and CVD risk factor status using logistic regression and analysis of covariance. Analyses were performed overall in women and stratified on obesity status; multivariate models controlled for age, apolipoprotein E (APOE) genotypes, and CVD risk factors. Food and nutrient profiles and overall nutritional risk of five non-overlapping habitual dietary patterns of women were identified including Heart Healthier, Lighter Eating, Wine and Moderate Eating, Higher Fat, and Empty Calories. Rates of hypertension and low high-density lipoprotein levels were high in non-obese women, but individual MetS risk factor levels were substantially increased in obese women. Overall MetS risk varied by dietary pattern and obesity status, independently of APOE and CVD risk factors. Compared with obese or non-obese women and women overall with other dietary patterns, MetS was highest in those with the Empty Calorie pattern (contrast p value: p<0.05). This research shows the independent relationship between habitual dietary patterns and MetS risk in FOS women and the influence of obesity status. High overall MetS risk and the varying prevalence of individual MetS risk factors in female subgroups emphasize the importance of preventive nutrition interventions and suggest potential benefits of targeted behavior change in both obese and non-obese women by dietary pattern.

  12. Validity of the Framingham point scores in the elderly: results from the Rotterdam study.

    Science.gov (United States)

    Koller, Michael T; Steyerberg, Ewout W; Wolbers, Marcel; Stijnen, Theo; Bucher, Heiner C; Hunink, M G Myriam; Witteman, Jacqueline C M

    2007-07-01

    The National Cholesterol Education Program recommends assessing 10-year risk of coronary heart disease (CHD) in individuals free of established CHD with the Framingham Point Scores (FPS). Individuals with a risk >20% are classified as high risk and are candidates for preventive intervention. We aimed to validate the FPS in a European population of elderly subjects. Subjects free of established CHD at baseline were selected from the Rotterdam study, a population-based cohort of subjects 55 years or older in The Netherlands. We studied calibration, discrimination (c-index), and the accuracy of high-risk classifications. Events consisted of fatal CHD and nonfatal myocardial infarction. Among 6795 subjects, 463 died because of CHD and 336 had nonfatal myocardial infarction. Predicted 10-year risk of CHD was on average well calibrated for women (9.9% observed vs 10.1% predicted) but showed substantial overestimation in men (14.3% observed vs 19.8% predicted), particularly with increasing age. This resulted in substantial number of false-positive classifications (specificity 70%) in men. In women, discrimination of the FPS was better than that in men (c-index 0.73 vs 0.63, respectively). However, because of the low baseline risk of CHD and limited discriminatory power, only 33% of all CHD events occurred in women classified as high risk. The FPS need recalibration for elderly men with better incorporation of the effect of age. In elderly women, FPS perform reasonably well. However, maintaining the rational of the high-risk threshold requires better performing models for a population with low incidence of CHD.

  13. Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study.

    Science.gov (United States)

    Saber, Hamidreza; Himali, Jayandra J; Beiser, Alexa S; Shoamanesh, Ashkan; Pikula, Aleksandra; Roubenoff, Ronenn; Romero, Jose R; Kase, Carlos S; Vasan, Ramachandran S; Seshadri, Sudha

    2017-07-01

    Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet, prospective data linking IGF-1 levels to the development of ischemic stroke remain inconclusive. We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke. We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990-1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders. During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potential confounders, higher IGF-1 levels were associated with a lower risk of incident ischemic stroke, with subjects in the lowest quintile of IGF-1 levels having a 2.3-fold higher risk of incident ischemic stroke (95% confidence interval, 1.09-5.06; P =0.03) as compared with those in the top quintile. We observed an effect modification by diabetes mellitus and waist-hip ratio for the association between IGF-1 and ischemic stroke ( P <0.1). In subgroup analyses, the effects were restricted to subjects with diabetics and those in top waist-hip ratio quartile, in whom each standard deviation increase in IGF-1 was associated with a 61% (hazard ratio, 0.39; 95% confidence interval, 0.20-0.78; P =0.007) and 41% (hazard ratio, 0.59; 95% confidence interval, 0.37-0.95; P =0.031) lower risk of incident ischemic stroke, respectively. IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance. © 2017 American Heart Association, Inc.

  14. Calcium intake is not associated with increased coronary artery calcification: the Framingham Study.

    Science.gov (United States)

    Samelson, Elizabeth J; Booth, Sarah L; Fox, Caroline S; Tucker, Katherine L; Wang, Thomas J; Hoffmann, Udo; Cupples, L Adrienne; O'Donnell, Christopher J; Kiel, Douglas P

    2012-12-01

    Adequate calcium intake is known to protect the skeleton. However, studies that have reported adverse effects of calcium supplementation on vascular events have raised widespread concern. We assessed the association between calcium intake (from diet and supplements) and coronary artery calcification, which is a measure of atherosclerosis that predicts risk of ischemic heart disease independent of other risk factors. This was an observational, prospective cohort study. Participants included 690 women and 588 men in the Framingham Offspring Study (mean age: 60 y; range: 36-83 y) who attended clinic visits and completed food-frequency questionnaires in 1998-2001 and underwent computed tomography scans 4 y later in 2002-2005. The mean age-adjusted coronary artery-calcification Agatston score decreased with increasing total calcium intake, and the trend was not significant after adjustment for age, BMI, smoking, alcohol consumption, vitamin D-supplement use, energy intake, and, for women, menopause status and estrogen use. Multivariable-adjusted mean Agatston scores were 2.36, 2.52, 2.16, and 2.39 (P-trend = 0.74) with an increasing quartile of total calcium intake in women and 4.32, 4.39, 4.19, and 4.37 (P-trend = 0.94) in men, respectively. Results were similar for dietary calcium and calcium supplement use. Our study does not support the hypothesis that high calcium intake increases coronary artery calcification, which is an important measure of atherosclerosis burden. The evidence is not sufficient to modify current recommendations for calcium intake to protect skeletal health with respect to vascular calcification risk.

  15. Evidence that meniscus damage may be a component of osteoarthritis: the Framingham study.

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    Englund, M; Haugen, I K; Guermazi, A; Roemer, F W; Niu, J; Neogi, T; Aliabadi, P; Felson, D T

    2016-02-01

    The etiology of degenerative meniscus tear is unclear but could be related to a generalized osteoarthritic disease process. We studied whether radiographic hand osteoarthritis (OA) is associated with meniscus damage. We examined 974 persons aged 50-90 years drawn via census tract data and random-digit dialing from Framingham, Massachusetts, United States. One reader assessed bilateral hand radiographs (30 joints) and another read frontal knee radiographs, all according to the Kellgren-Lawrence (KL) scale. A third reader assessed right knee 1.5-T magnetic resonance imaging (MRI) scans for meniscus damage. We calculated the prevalence of medial and/or lateral meniscus damage in those with one to two and three or more finger joints with radiographic OA (KL grade ≥2) compared to those without radiographic hand OA with adjustment for age, sex, and body mass index. We also evaluated the above association in persons without evidence of radiographic OA (KL grade 0) in their knee (n = 748). The prevalence of meniscus damage in the knee of subjects with no, one to two, and three or more finger joints with OA was 24.9%, 31.7%, and 47.2%, respectively. The adjusted prevalence ratio (PR) of having meniscus damage was significantly increased in those who had three or more finger joints with OA (1.40 [95% confidence interval (CI) 1.11-1.77]). The estimate remained similar in persons without evidence of radiographic OA in their knee (PR, 1.42 [95% CI 1.03-1.97]). The association was more robust for medial meniscus damage. Results suggest a common non-age related etiologic pathway for both radiographic hand OA and meniscus damage. Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  16. Sixteen-Year Experience of David and Bentall Procedures in Acute Type A Aortic Dissection.

    Science.gov (United States)

    Yang, Bo; Patel, Himanshu J; Sorek, Claire; Hornsby, Whitney E; Wu, Xiaoting; Ward, Sarah; Thomas, Marc; Driscoll, Anisa; Waidley, Victoria A; Norton, Elizabeth L; Likosky, Donald S; Deeb, G Michael

    2018-03-01

    To examine short-term and midterm outcomes after the David and Bentall procedures in patients with an acute type A aortic dissection. Between 2001 and 2017, patients (n = 135) with acute type A aortic dissection underwent an aortic root replacement with either the David (n = 40) or Bentall (n = 95) procedure. Perioperative outcome, reoperation rate, aortic valve function, and long-term survival were evaluated. The median age of the entire cohort was 56 years. Rates of malperfusion (21%), shock (16%), history of renal failure (4%), and extent of surgery were similar between David and Bentall groups. However, the David group was significantly younger (45 versus 61 years) with less hypertension (45% versus 66%), coronary artery disease (0% versus 17%), valvulopathy (5% versus 19%), and prior cardiac surgery (5% versus 21%). Overall operative mortality was 9.6% (David 3% and Bentall 13%). Composite outcome comprising myocardial infarction, stroke, new-onset renal failure, and operative mortality was 18% in the entire cohort (David 5% and Bentall 23%). In the David group, the freedom of moderate aortic insufficiency was 95% at 10 years. The rate of reoperation for pathology of the proximal aorta or aortic valve was 0% and 2% for the David and Bentall groups, respectively. Ten-year Kaplan-Meier survival was 66% (95% confidence interval: 51% to 77%) for the entire cohort, with 98% (95% confidence interval: 84% to 99%) survival in the David group and 57% (95% confidence interval: 42% to 70%) survival in the Bentall group. Both the David and Bentall procedures are appropriate surgical approaches for aortic root replacement in select patients with an acute type A aortic dissection. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  17. En la población Canaria, la función de Framingham estima mejor el riesgo de mortalidad cardiovascular que la función SCORE Framingham function estimates the risk of cardio vascular mortality more effectively than SCORE function in the population of the Canary Islands (Spain

    Directory of Open Access Journals (Sweden)

    Antonio Cabrera de León

    2009-06-01

    Full Text Available Objetivos: Comparar la estimación de eventos cardiovasculares fatales con las funciones de Framingham y SCORE, además de explorar su capacidad para detectar el riesgo aportado por factores no incluidos en sus ecuaciones: sedentarismo, obesidad, perímetro abdominal, razón abdomen/estatura, razón abdomen/pelvis y consumo excesivo de alcohol. Métodos: Estudio transversal de 5.289 personas, de 30 a 69 años de edad, obtenidas por muestreo aleatorio en la población general de Canarias. Se calibraron las funciones de Framingham y SCORE, y se estimó su concordancia. Se obtuvo, para estas edades, la tasa poblacional de mortalidad cardiovascular y se confrontó con el riesgo predicho por las funciones. Resultados: En los hombres, la tasa de mortalidad por 100.000 habitantes fue de 67,4, en tanto que la estimación de Framingham, SCORE-Low y SCORE-High fue de 80, 140 y 270, respectivamente. En las mujeres, frente a una tasa de 19,3, la estimación fue de 30, 50 y 70, respectivamente. Ambas funciones detectaron el incremento del riesgo aportado por los factores estudiados, con la excepción, en las mujeres, del sedentarismo con SCORE y del consumo excesivo de alcohol con ambas funciones. En los hombres, tomando para Framingham los puntos de corte de >12%, >15% y >20%, la concordancia con SCORE-Low produjo una Kappa de 0,6, 0,7 y 0,5, respectivamente. Conclusiones: La función de Framingham estimó mejor las tasas de mortalidad que la función SCORE. Únicamente la función de Framingham detectó en ambos sexos el riesgo cardiovascular aportado por el sedentarismo. En Canarias recomendamos la aplicación de la función de Framingham calibrada.Introduction: To compare the performance of the Framingham and SCORE functions to estimate fatal cardiovascular events. In addition, we explored the ability of both functions to detect the risk contributed by factors not included in their equations: sedentariness, obesity, abdominal circumference, abdomen

  18. Decay of Ethics in David Mamet’s American Buffalo

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    Ehsan Dehghani

    2013-09-01

    Full Text Available The American Dream is a recurrent theme in American literature. In this response, this paper is an attempt to expose the destructive effects of the dream on human spirits and relations and how it is contradicted in different ways through the analysis of his brilliant play, American Buffalo by David Mamet. Beneath the seeming simple surface of the play lies a deep current of meanings that reflect the calamities of modern American life, and in a broader sense, the modern world. This article indicates how capitalism inculcates ideologies in the mind of individuals in order to facilitate the exploiting process and unquestioning subordination. Ragged individualism, as one of these ideologies, disrupts all communal bonds and even exceeds to the disintegration of friendship and family life. On the other hand, this individualism, as an ideology, is sustained by other capitalist ideologies such as advertising, consumerism and emulation. It will also be discussed that monetary interests are all one seeks in a highly competitive atmosphere and nothing is privileged over business ethics. In brief, this reading of the play tries to illuminate that we live in a dream-like world of ideologies that block logical thinking and forge our relationship with our real existence through less suspected ways.

  19. Reconstructing apology: David Cameron's Bloody Sunday apology in the press.

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    McNeill, Andrew; Lyons, Evanthia; Pehrson, Samuel

    2014-12-01

    While there is an acknowledgement in apology research that political apologies are highly mediated, the process of mediation itself has lacked scrutiny. This article suggests that the idea of reconstruction helps to understand how apologies are mediated and evaluated. David Cameron's apology for Bloody Sunday is examined to see how he constructs four aspects of apology: social actors, consequences, categorization, and reasons. The reconstruction of those aspects by British, Unionist, and Nationalist press along with reconstructions made by soldiers in an online forum are considered. Data analysis was informed by thematic analysis and discourse analysis which helped to explore key aspects of reconstruction and how elements of Cameron's apology are altered in subsequent mediated forms of the apology. These mediated reconstructions of the apology allowed their authors to evaluate the apology in different ways. Thus, in this article, it is suggested that the evaluation of the apology by different groups is preceded by a reconstruction of it in accordance with rhetorical goals. This illuminates the process of mediation and helps to understand divergent responses to political apologies. © 2013 The British Psychological Society.

  20. Sir David Brewster's changing ideas on the plurality of worlds

    Science.gov (United States)

    de Asúa, Miguel

    2006-06-01

    In the course of his long life the Scottish physicist David Brewster wrote copiously about the plurality of worlds. More Worlds than One (1854), perhaps his strongest statement on the question, was written as an answer to William Whewell's On the Plurality of Worlds (1853), which argued that life was a privilege of the Earth. Brewster's ideas changed drastically along the years in many crucial issues such as the habitability of the Sun and the Moon, the possibility that extraterrestrials could be different from humans, and the occupation of the Earth by intelligent races in the distant past. This paper succinctly surveys Brewster's main lines of thought about the plurality of worlds underlining the significance of his first two articles devoted exclusively to this topic. They were published in 1838 in The Monthly Chronicle, and affirm the habitability of the planets while denying that of the Moon. As is the case with many Victorian scientists, belief in pluralism was for Brewster part and parcel of a complex of ideas and attitudes in which it is hard to distinguish science from religion. I shall argue that a fair number of the shifting opinions and inconsistencies detectable in Brewster's ideas on the plurality of worlds can be attributed to the fact that these were used as pliable apologetic instruments in his scientific writings, many of which are permeated by strong religious concerns.

  1. Mind-modelling with corpus stylistics in David Copperfield.

    Science.gov (United States)

    Stockwell, Peter; Mahlberg, Michaela

    2015-05-01

    We suggest an innovative approach to literary discourse by using corpus linguistic methods to address research questions from cognitive poetics. In this article, we focus on the way that readers engage in mind-modelling in the process of characterisation. The article sets out our cognitive poetic model of characterisation that emphasises the continuity between literary characterisation and real-life human relationships. The model also aims to deal with the modelling of the author's mind in line with the modelling of the minds of fictional characters. Crucially, our approach to mind-modelling is text-driven. Therefore we are able to employ corpus linguistic techniques systematically to identify textual patterns that function as cues triggering character information. In this article, we explore our understanding of mind-modelling through the characterisation of Mr. Dick from David Copperfield by Charles Dickens. Using the CLiC tool (Corpus Linguistics in Cheshire) developed for the exploration of 19th-century fiction, we investigate the textual traces in non-quotations around this character, in order to draw out the techniques of characterisation other than speech presentation. We show that Mr. Dick is a thematically and authorially significant character in the novel, and we move towards a rigorous account of the reader's modelling of authorial intention.

  2. “Silencio”: hearing loss in David Lynch's Mulholland Drive

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    Allister Mactaggart

    2014-11-01

    Full Text Available In a filmmaking career replete with extraordinary images and sounds, David Lynch's Mulholland Drive (2001 stands out for attention as a striking and seemingly inexhaustible resource for analysis. In this article, this film is used to examine the specific ways in which Lynch uses pre-existing pop songs to wrap the spectator within the filmic soundscape. Nowhere is the complexity and uncanniness of pop music made more explicit than in Rebekah Del Rio's stunning performance of “Llorando (Crying” in the Club Silencio scene. The split between the singer's powerful performance and her subsequent collapse with the sound of the voice left hanging in the air marks a pivotal point in the film. This scene, coupled with other examples of feminine jouissance, is contrasted with the deadening roar of the master's voice, which solely demands obedience but is deaf to any reply. At the core of this article is an analysis of the status of the voice (and the gaze as examples of the Lacanian object a and its relationship to Marx's concept of surplus value. Mulholland Drive provides a powerful demonstration of how these concepts can be seen, heard, and felt in relation to film, and how sound can reverberate into the spaces and silences beyond the screen.

  3. David de Wied: Eminent scientist and academic leader: A personal note.

    Science.gov (United States)

    Gispen, Willem Hendrik

    2010-01-10

    David de Wied was a natural leader with many a talent. He was the director of the Rudolf Magnus Institute at Utrecht University and president of the Royal Netherlands Academy of Arts and Sciences. He coached over 75 Ph.D. students and hosted some 200 foreign scientists who joined him in his multidisciplinary neuropeptide research. Many of them became lifelong friends, frequenting the home of Liedje and David de Wied. Born in Deventer (The Netherlands) on January 12th, 1925, David de Wied's early boyhood first in Deventer and later in Leeuwarden appears to have been no different from that of any other provincial Dutch boys in pre-war Holland. After the war David enrolled at Groningen University to study medicine. Subsequently he specialized in experimental pharmacology. To understand the determination of David de Wied is to understand the drive of a Jewish young man, who during the war, had been forced to go underground and unable to develop in a free and independent manner. Therefore, later in life, time became very precious to him and everything that came across his path had to be taken seriously. In this short sketch of David de Wied I will try to highlight his outstanding scientific accomplishments as well as his personality as both have inspired a generation of young scientists. It is a great honour and a pleasure to be part of this meeting in memory of David de Wied.

  4. Effect of Birth Cohort on Risk of Hip Fracture: Age-Specific Incidence Rates in the Framingham Study

    Science.gov (United States)

    Samelson, Elizabeth J.; Zhang, Yuqing; Kiel, Douglas P.; Hannan, Marian T.; Felson, David T.

    2002-01-01

    Objectives. This study examined the effect of birth cohort on incidence rates of hip fracture among women and men in the Framingham Study. Methods. Age-specific incidence rates of first hip fracture were presented according to tertile of year of birth for 5209 participants of the Framingham Study, a population-based cohort followed since 1948. Sex-specific incidence rate ratios were calculated by Cox regression to assess the relation between birth cohort and hip fracture incidence. Results. An increasing trend in hip fracture incidence rates was observed with year of birth for women (trend, P = .05) and men (trend, P = .03). Relative to those born from 1887 to 1900 (incidence rate ratio [IRR] = 1.0), age-specific incidence rates were greatest in the most recent birth cohort, born from 1911 to 1921 (IRR = 1.4 for women, IRR = 2.0 for men), and intermediate in those born from 1901 to 1910 (IRR = 1.2 for women, IRR = 1.5 for men). Conclusions. Results suggest risk of hip fracture is increasing for successive birth cohorts. Projections that fail to account for the increase in rates associated with birth cohort underestimate the future public health impact of hip fracture in the United States. PMID:11988460

  5. Association Between Dietary Fiber Intake and Bone Loss in the Framingham Offspring Study.

    Science.gov (United States)

    Dai, Zhaoli; Zhang, Yuqing; Lu, Na; Felson, David T; Kiel, Douglas P; Sahni, Shivani

    2018-02-01

    Dietary fiber may increase calcium absorption, but its role in bone mineralization is unclear. Furthermore, the health effect of dietary fiber may be different between sexes. We examined the association between dietary fiber (total fiber and fiber from cereal, fruits, vegetables, nuts, and legumes) and bone loss at the femoral neck, trochanter, and lumbar spine (L 2 to L 4 ) in older men and women. In the Framingham Offspring Study, at baseline (1996-2001), diet was assessed using the Willett food-frequency questionnaire, and bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry. Follow-up BMD was measured in 2001-2005 and 2005-2008 among 792 men (mean age 58.1 years; BMI 28.6 kg/m 2 ) and 1065 women (mean age 57.3 years; BMI 27.2 kg/m 2 ). We used sex-specific generalized estimating equations in multivariable regressions to estimate the difference (β) of annualized BMD change in percent (%ΔBMD) at each skeletal site per 5 g/d increase in dietary fiber. We further estimated the adjusted mean for bone loss (annualized %ΔBMD) among participants in each higher quartile (Q2, Q3, or Q4) compared with those in the lowest quartile (Q1) of fiber intake. Higher dietary total fiber (β = 0.06, p = 0.003) and fruit fiber (β = 0.10, p = 0.008) was protective against bone loss at the femoral neck in men but not in women. When examined in quartiles, men in Q2-Q4 of total fiber had significantly less bone loss at the femoral neck versus those in Q1 (all p fiber from vegetables appeared to be protective against spine bone loss in women but not men. There were no associations with cereal fiber or nut and legume fiber and bone loss in men or women. Our findings suggest that higher dietary fiber may modestly reduce bone loss in men at the hip. © 2017 American Society for Bone and Mineral Research. © 2017 American Society for Bone and Mineral Research.

  6. Short-Term Exposure to Air Pollution and Lung Function in the Framingham Heart Study

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    Ljungman, Petter L.; Wilker, Elissa H.; Gold, Diane R.; Schwartz, Joel D.; Koutrakis, Petros; Washko, George R.; O’Connor, George T.; Mittleman, Murray A.

    2013-01-01

    Rationale: Short-term exposure to ambient air pollution has been associated with lower lung function. Few studies have examined whether these associations are detectable at relatively low levels of pollution within current U.S. Environmental Protection Agency (EPA) standards. Objectives: To examine exposure to ambient air pollutants within EPA standards and lung function in a large cohort study. Methods: We included 3,262 participants of the Framingham Offspring and Third Generation cohorts living within 40 km of the Harvard Supersite monitor in Boston, Massachusetts (5,358 examinations, 1995–2011) who were not current smokers, with previous-day pollutant levels in compliance with EPA standards. We compared lung function (FEV1 and FVC) after previous-day exposure to particulate matter less than 2.5 μm in diameter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) in the “moderate” range of the EPA Air Quality Index to exposure in the “good” range. We also examined linear relationships between moving averages of pollutant concentrations 1, 2, 3, 5, and 7 days before spirometry and lung function. Measurements and Main Results: Exposure to pollutant concentrations in the “moderate” range of the EPA Air Quality Index was associated with a 20.1-ml lower FEV1 for PM2.5 (95% confidence interval [CI], −33.4, −6.9), a 30.6-ml lower FEV1 for NO2 (95% CI, −60.9, −0.2), and a 55.7-ml lower FEV1 for O3 (95% CI, −100.7, −10.8) compared with the “good” range. The 1- and 2-day moving averages of PM2.5, NO2, and O3 before testing were negatively associated with FEV1 and FVC. Conclusions: Short-term exposure to PM2.5, NO2, and O3 within current EPA standards was associated with lower lung function in this cohort of adults. PMID:24200465

  7. Dietary factors and incident atrial fibrillation: the Framingham Heart Study123

    Science.gov (United States)

    Shen, Jian; Johnson, Victor M; Sullivan, Lisa M; Jacques, Paul F; Magnani, Jared W; Lubitz, Steven A; Pandey, Shivda; Levy, Daniel; Vasan, Ramachandran S; Quatromoni, Paula A; Junyent, Mireia; Ordovas, Jose M; Benjamin, Emelia J

    2011-01-01

    Background: There have been conflicting reported associations between dietary factors and incident atrial fibrillation (AF). Objective: We evaluated associations between consumption of alcohol, caffeine, fiber, and polyunsaturated fatty acids (PUFAs) and incident AF in the Framingham Heart Study. Design: Participants without AF (n = 4526; 9640 examinations; mean age: 62 y; 56% women) from the original and offspring cohorts completed food-frequency questionnaires and were followed prospectively for 4 y. We examined the associations between dietary exposures and AF with Cox proportional hazards regression. Results: A total of 296 individuals developed AF (177 men, 119 women). In multivariable analyses, there were no significant associations between examined dietary exposures and AF risk. Hazard ratios (HRs) for increasing quartiles of dietary factors were as follows: for alcohol, 0.73 (95% CI: 0.5, 1.05), 0.85 (95% CI: 0.61, 1.18), and 1.12 (95% CI: 0.83, 1.51) (P for trend = 0.48); for caffeine, 0.84 (95% CI: 0.62, 1.15), 0.87 (95% CI: 0.64, 1.2), and 0.98 (95% CI: 0.7, 1.39) (P for trend = 0.84); for total fiber, 0.86 (95% CI: 0.61, 1.2), 0.64 (95% CI: 0.44, 0.92), and 0.81 (95% CI: 0.54, 1.2) (P for trend = 0.16); and for n−3 (omega-3) PUFAs, 1.11 (95% CI: 0.81, 1.54), 0.92 (95% CI: 0.65, 1.29), and 1.18 (95% CI: 0.85, 1.64) (P for trend = 0.57; quartile 1 was the reference group). In exploratory analyses, consumption of >4 servings of dark fish/wk (5 cases and 21 individuals at risk) was significantly associated with AF risk compared with the consumption of <1 serving of dark fish/wk (HR: 6.53; 95% CI: 2.65, 16.06; P < 0.0001). Conclusions: Consumption of alcohol, caffeine, fiber, and fish-derived PUFAs was not significantly associated with AF risk. The observed adverse association between the consumption of dark fish and AF merits further investigation. Our findings suggest that the dietary exposures examined convey limited attributable risk of AF in the

  8. Visceral Adipose Tissue Is Associated With Bone Microarchitecture in the Framingham Osteoporosis Study.

    Science.gov (United States)

    Liu, Ching-Ti; Broe, Kerry E; Zhou, Yanhua; Boyd, Steven K; Cupples, L Adrienne; Hannan, Marian T; Lim, Elise; McLean, Robert R; Samelson, Elizabeth J; Bouxsein, Mary L; Kiel, Douglas P

    2017-01-01

    Obesity has been traditionally considered to protect the skeleton against osteoporosis and fracture. Recently, body fat, specifically visceral adipose tissue (VAT), has been associated with lower bone mineral density (BMD) and increased risk for some types of fractures. We studied VAT and bone microarchitecture in 710 participants (58% women, age 61.3 ± 7.7 years) from the Framingham Offspring cohort to determine whether cortical and trabecular BMD and microarchitecture differ according to the amount of VAT. VAT was measured from CT imaging of the abdomen. Cortical and trabecular BMD and microarchitecture were measured at the distal tibia and radius using high-resolution peripheral quantitative computed tomography (HR-pQCT). We focused on 10 bone parameters: cortical BMD (Ct.BMD), cortical tissue mineral density (Ct.TMD), cortical porosity (Ct.Po), cortical thickness (Ct.Th), cortical bone area fraction (Ct.A/Tt.A), trabecular density (Tb.BMD), trabecular number (Tb.N), trabecular thickness (Tb.Th), total area (Tt.Ar), and failure load (FL) from micro-finite element analysis. We assessed the association between sex-specific quartiles of VAT and BMD, microarchitecture, and strength in all participants and stratified by sex. All analyses were adjusted for age, sex, and in women, menopausal status, then repeated adjusting for body mass index (BMI) or weight. At the radius and tibia, Ct.Th, Ct.A/Tt.A, Tb.BMD, Tb.N, and FL were positively associated with VAT (all p-trend <0.05), but no other associations were statistically significant except for higher levels of cortical porosity with higher VAT in the radius. Most of these associations were only observed in women, and were no longer significant when adjusting for BMI or weight. Higher amounts of VAT are associated with greater BMD and better microstructure of the peripheral skeleton despite some suggestions of significant deleterious changes in cortical measures in the non-weight bearing radius. Associations were

  9. La economía emprendedora de David Audretsch

    Directory of Open Access Journals (Sweden)

    Maria Callejón

    2009-01-01

    Full Text Available Pocos campos de la Economía cuentan con mejores bases teóricas que la Organización Industrial. Y David Audretsch ha contribuido en gran medida a mejorar el campo de la OI con sus modelos de emprendeduría y, también, con la inspiración y el estímulo que ha infundido a otros académicos. En el artículo publicado en este número monográfico, Audretsch plantea dos conceptos principales: uno es el modelo del filtro del conocimiento; el otro la idea de capital emprendedor. El concepto de filtro del conocimiento es central en la actual discusión sobre la relación entre la generación de conocimiento científico y tecnológico y su grado efectivo de traslación a innovaciones en el mercado. Muestra por qué y cómo los agentes que generan el conocimiento rara vez son los mismos que llegan a comercializarlos. Con frecuencia el puente es un emprendedor. La segunda idea aquí resaltada es el capital emprendedor y cómo la noción se ha popularizado gracias a la publicación de numerosos informes sobre tasas de creación de empresas. En este caso, aunque el concepto teórico sea valioso, ocurre que los estudios empíricos han arrojado pocos y contradictorios resultados.

  10. La economía emprendedora de David Audretsch

    Directory of Open Access Journals (Sweden)

    Maria Callejón

    2009-10-01

    Full Text Available Pocos campos de la Economía cuentan con mejores bases teóricas que la Organización Industrial. Y David Audretsch ha contribuido en gran medida a mejorar el campo de la OI con sus modelos de emprendeduría y, también, con la inspiración y el estímulo que ha infundido a otros académicos. En el artículo publicado en este número monográfico, Audretsch plantea dos conceptos principales: uno es el modelo del filtro del conocimiento; el otro la idea de capital emprendedor. El concepto de filtro del conocimiento es central en la actual discusión sobre la relación entre la generación de conocimiento científico y tecnológico y su grado efectivo de traslación a innovaciones en el mercado. Muestra por qué y cómo los agentes que generan el conocimiento rara vez son los mismos que llegan a comercializarlos. Con frecuencia el puente es un emprendedor. La segunda idea aquí resaltada es el capital emprendedor y cómo la noción se ha popularizado gracias a la publicación de numerosos informes sobre tasas de creación de empresas. En este caso, aunque el concepto teórico sea valioso, ocurre que los estudios empíricos han arrojado pocos y contradictorios resultados.

  11. Physical activity, the Framingham risk score and risk of coronary heart disease in men and women of the EPIC-Norfolk study

    NARCIS (Netherlands)

    Arsenault, Benoit J.; Rana, Jamal S.; Lemieux, Isabelle; Després, Jean-Pierre; Wareham, Nicholas J.; Kastelein, John J. P.; Boekholdt, S. Matthijs; Khaw, Kay-Tee

    2010-01-01

    Objective: Test the hypothesis that considering leisure-time and work-related physical activity habits in addition to the Framingham risk score (FRS) would result into better classification of coronary heart disease (CHD) risk than FRS alone. Methods: Prospective, population-based study of 9564 men

  12. Jewish Influences upon Islamic Storytelling : The Case of David and Bathsheba

    NARCIS (Netherlands)

    Poorthuis, Marcel; van Staalduine, Eveline; Spronk, Klaas

    2018-01-01

    The embarassing act of David towards Bathsheba has received ample treatment in Judaism and Islam. It is striking how Islam avails itself of jewish apologetics (Israiliyyat), whereas later on the existence of Bathsheba will be denied altogether.

  13. Miks meil on kogu aeg kiire? / David Allen ; interv. Endrik Randoja

    Index Scriptorium Estoniae

    Allen, David

    2006-01-01

    Produktiivsuse ekspert vastab küsimustele ettevõetud tegevuste tulemuslikumalt lõpule viimise kohta. Lisa: Aja paremaks kasutamiseks pakub David Allen lisaks veel kolm tõhusat ja lihtsasti rakendatavat põhimõtet

  14. David Oistrahhi festival läheneb lõpule / Toivo Traks

    Index Scriptorium Estoniae

    Traks, Toivo

    2006-01-01

    Kontsertidest David Oistrahhi festivali raames: saksa viola da gamba mängija Holger Faust-Peters ja klavessinist Iren Lill 19. juulil Pärnu Eliisabeti kirikus, briti laulja Patricia Rozario ja RTE Vanbrugh Quartet 20. juulil Eliisabeti kirikus

  15. Islandi otsus tunnustada Eestit ei tulnud kergelt / David Oddsson ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Oddsson, David

    2006-01-01

    Islandi endine peaminister David Oddsson räägib Eesti iseseisvuse tunnustamisest 1991. aastal. Vt. samas: Eestisse saabus visiidile Islandi peaminister. Geir H. Haarde koos abikaasaga külastab Eestit

  16. Siim Nestor soovitab : David Morales. Reede ja laupäeva parimad palad / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2004-01-01

    Popmuusikaüritustest: David Morales 15. apr. klubis Moskva, "Eklekter" 16. apr Von Krahlis (esinejaks rootsi diskor DJ Mad Mats), prantsuse diskor DJ Yellow 16. apr. klubis Hollywood, üritusest "Dependent" 17. apr. Tartus

  17. Clinton või Trump - USA jaoks ühtviisi katastroof / David Satter ; intervjueerinud Taavi Minnik

    Index Scriptorium Estoniae

    Satter, David

    2016-01-01

    Intervjuu maineka Ühendriikide Venemaa eksperdi David Satteriga, kes hoiatab, et Ameerika presidendivalimistel on inimestel valida kahe äärmiselt halva kandidaadi - Donald Trumpi ning Hillary Clintoni vahel

  18. "Handbook of biomedical optics", edited by David A. Boas, Constantinos Pitris, and Nimmi Ramanujam

    Science.gov (United States)

    2012-01-01

    David A. Boas, Constantinos Pitris, and Nimmi Ramanujam, Eds.: Handbook of Biomedical Optics CRC Press, Taylor and Francis Group, Boca Raton, London, New York, 2011 ISBN: 978-1-4200-9036-9 (Hardback), 787 pages

  19. Anneli Remme soovitab : David Oistrahhi festival. Koorifestival Pärnus / Anneli Remme

    Index Scriptorium Estoniae

    Remme, Anneli, 1968-

    2002-01-01

    David Oistrahhi festivalist 14. juulini Pärnu Eliisabeti kirikus, Teatris Endla, Ammende villas, Eesti Õigeusu kirikus ja Pärnu Raekojas. Festivali kunstiline juht Allar Kaasik. Pärnu koorifestivalist

  20. Jalutu David tantsib auhinna vääriliselt / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2006-01-01

    Tantsufilm "Elu hind" ("The Cost of Living") : lavastaja ja koreograaf Lloyd Newson : peaosades David Toole, Eddie Kay : Suurbritannia 2004. Filmi aluseks on Londoni tantsuteatri DV 8 Physical Theatre' 2000.a. valminud lavastus

  1. Õigeksmõistev otsus vallandas publiku tormilise aplausi / Tiiu Põld ; kommenteerinud David Vseviov ; Marju Lauristin

    Index Scriptorium Estoniae

    Põld, Tiiu, 1945-

    2009-01-01

    Harju maakohtu õigeksmõistvast otsusest aprillirahutuste korraldamises süüdistatavate Dmitri Linteri, Maksim Reva, Dimitri Klenski ja Mark Sirõki kohta. Kommenteerivad David Vseviov ja Marju Lauristin

  2. Open Access!: Review of Online Statistics: An Interactive Multimedia Course of Study by David Lane

    Directory of Open Access Journals (Sweden)

    Samuel L. Tunstall

    2016-01-01

    Full Text Available David M. Lane (project leader. Online Statistics Education: An Interactive Multimedia Course of Study (http://onlinestatbook.com/ Also: David M. Lane (primary author and editor, with David Scott, Mikki Hebl, Rudy Guerra, Dan Osherson, and Heidi Zimmer. Introduction to Statistics. Online edition (http://onlinestatbook.com/Online_Statistics_Education.pdf, 694 pp. It is rare that students receive high-quality textbooks for free, but David Lane's Online Statistics: An Interactive Multimedia Course of Study permits precisely that. This review gives an overview of the many features in Lane's online textbook, including the Java Applets, the textbook itself, and the resources available for instructors. A discussion of uses of the site, as well as a comparison of the text to alternative online statistics textbooks, is included.

  3. Prozaci asemel GTD ehk getting things done / David Allen ; interv. Endrik Randoja

    Index Scriptorium Estoniae

    Allen, David

    2007-01-01

    Konsultant ja koolitaja David Allen oma aja- ja enesejuhtimise meetodist GTD - getting things done. Vt. samas: Väikesed nipid, et tõhusam olla; Milles seisneb Alleni meetod; Kuidas ma oma ülesannet täitsin - logiraamat

  4. Osborne's trilogy : a critique of the management philosophy of David Osborne / Jan-Erik Lane

    Index Scriptorium Estoniae

    Lane, Jan-Erik

    2006-01-01

    Kriitiline lühiülevaade David Osborne'i raamatutes Reinventing government (kaasautor T. Gaebler, 1992), Banishing bureaucracy (kaasautor P. Plastrik, 1997) ja The price of government (kaasautor P. Hutchinson, 2004) avaldatud teooriatest

  5. [David Feest. Zwangskollektivierung im Baltikum : die Sowjetisierung des estnischen Dorfes 1944-1953] / Anu Mai Kõll

    Index Scriptorium Estoniae

    Kõll, Anu Mai, 1946-

    2008-01-01

    Arvustus: Feest, David. Zwangskollektivierung im Baltikum : die Sowjetisierung des estnischen Dorfes 1944-1953. Köln [etc.] : Böhlau, 2007. Esimesest rahvusvaheliselt kättesaadavast laiahaardelisest Eesti kollektiviseerimist käsitlevast teosest

  6. [Jaan Kross ja David Samoilov. Mu sõbra avatud akna all] / M. J.

    Index Scriptorium Estoniae

    Jõgi, Mall, 1947-

    2016-01-01

    Tutvustus: Kross, Jaan. Mu sõbra avatud akna all : [luuletused ja tõlked] = В окно моего друга : [стихи и переводы] / Jaan Kross ja David Samoilov ; Tallinna Ülikool. Tallinn : Avenarius, 2015 ; David Samoilovi Pärnu : teejuht. Luuletusi. Tallinn : Avenarius, 2015

  7. Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score.

    Directory of Open Access Journals (Sweden)

    Neda Seyedsadjadi

    Full Text Available Oxidative stress has been closely linked to the progressive cell damage associated with emerging non-communicable disease (NCDs. Early detection of these biochemical abnormalities before irreversible cell damage occurs may therefore be useful in identifying disease risk at an individual level. In order to test this hypothesis, this study assessed the relationship between a simple measure of redox status and lifestyle risk factors for NCDs, and the population-based risk score of Framingham. In a cross-sectional study design, 100 apparently healthy middle-aged males (n = 48 and females (n = 52 were asked to complete a comprehensive lifestyle assessment questionnaire, followed by body fat percentage and blood pressure measurements, and blood collection. The ratio of plasma total antioxidant capacity to hydroperoxide (TAC/HPX was used as an index of redox balance. One-way ANOVA and multiple linear regression analysis were performed to analyse the association between TAC/HPX, lifestyle components and other plasma biomarkers. The TAC/HPX ratio was higher in males compared to females (t96 = 2.34, P = 0.021. TAC/HPX was also lower in participants with poor sleep quality (t93 = 2.39, P = 0.019, with high sleep apnoea risk (t62.2 = 3.32, P = 0.002, with high caffeine (F(2, 93 = 3.97, P = 0.022 and red meat intake (F(2, 93 = 5.55, P = 0.005. These associations were independent of gender. Furthermore, the TAC/HPX ratio decreased with increasing body fat percentage (F(2, 95 = 4.74, P = 0.011 and depression score (t94 = 2.38, P = 0.019, though these associations were dependent on gender. Importantly, a negative association was observed between TAC/HPX levels and the Framingham risk score in both males (r(45 = -0.39, P = 0.008 and females (r(50 = -0.33, P = 0.019 that was independent of other Framingham risk score components. Findings from this study suggests that a relatively simple measure of redox balance such as the TAC/HPX ratio may be a sensitive

  8. Beyond Framingham risk factors and coronary calcification: does aortic valve calcification improve risk prediction? The Heinz Nixdorf Recall Study.

    Science.gov (United States)

    Kälsch, Hagen; Lehmann, Nils; Mahabadi, Amir A; Bauer, Marcus; Kara, Kaffer; Hüppe, Patricia; Moebus, Susanne; Möhlenkamp, Stefan; Dragano, Nico; Schmermund, Axel; Stang, Andreas; Jöckel, Karl-Heinz; Erbel, Raimund

    2014-06-01

    Aortic valve calcification (AVC) is considered a manifestation of atherosclerosis. In this study, we investigated whether AVC adds to cardiovascular risk prediction beyond Framingham risk factors and coronary artery calcification (CAC). A total of 3944 subjects from the population based Heinz Nixdorf Recall Study (59.3±7.7 years; 53% females) were evaluated for coronary events, stroke, and cardiovascular disease (CVD) events (including all plus CV death) over 9.1±1.9 years. CT scans were performed to quantify AVC. Cox proportional hazards regressions and Harrell's C were used to examine AVC as event predictor in addition to risk factors and CAC. During follow-up, 138 (3.5%) subjects experienced coronary events, 101 (2.6%) had a stroke, and 257 (6.5%) experienced CVD events. In subjects with AVC>0 versus AVC=0 the incidence of coronary events was 8.0% versus 3.0% (pAVC scores (pAVC scores (3rd tertile) remained independently associated with coronary events (HR 2.21, 95% CI 1.28 to 3.81) and CVD events (HR 1.67, 95% CI 1.08 to 2.58). After further adjustment for CAC score, HRs were attenuated (coronary events 1.55, 95% CI 0.89 to 2.69; CVD events 1.29, 95% CI 0.83 to 2.00). When adding AVC to the model containing traditional risk factors and CAC, Harrell's C indices did not increase for coronary events (from 0.744 to 0.744) or CVD events (from 0.759 to 0.759). AVC is associated with incident coronary and CVD events independent of Framingham risk factors. However, AVC fails to improve cardiovascular event prediction over Framingham risk factors and CAC. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  9. [Carotid intima-media thickness distribution according to the stratification of cardiovascular risk by means of Framingham-REGICOR and score function charts].

    Science.gov (United States)

    Hermida-Ameijeiras, Á; López-Paz, J E; Riveiro-Cruz, M A; Calvo-Gómez, C

    2016-01-01

    Carotid intima-media thickness (cIMT) has been suggested as a further tool for risk function charts. The aim of this study was to describethe relationship between cIMT and cardiovascular risk (CVR) estimation according to Framingham-REGICOR and SCORE equations. Observational, cross-sectional cohort study from 362 hypertensive subjects. Demographic and clinical information were collected as well as laboratory, ultrasonographic and CVR estimation by the Framingham-REGICOR and SCORE functions. Statistical analysis was performed using SPSS software (version 20,0). To analyze the data, statistical tests such as Chi-square, T-test, ANOVA, and Pearson correlation coefficient were used. According to both functions, differences on mean cIMT were found between low CVR group and intermediate to high groups. No differences were found between intermediate and high risk groups (cIMT: 0,73mm low risk patients vs. 0,89 or 0,88mm respectively according to SCORE function and cIMT: 0,73 vs. 0,85 or 0,87mm respectively according to Framingham-REGICOR function). cIMT correlated positively with CVR estimation according to both SCORE (r=0,421; P<.01), and Framingham-REGICOR functions (r=0,363; P<.01). cIMT correlates positively with CVR estimated by SCORE and Framingham-REGICOR functions. cIMT in those subjects at intermediate risk is similar to those at high risk. Our findings highlight the importance of carotid ultrasound in identifying silent target-organ damage in those patients at intermediate CVR. Copyright © 2015 SEHLELHA. Published by Elsevier España, S.L.U. All rights reserved.

  10. The systolic blood pressure difference between arms and cardiovascular disease in the Framingham Heart Study.

    Science.gov (United States)

    Weinberg, Ido; Gona, Philimon; O'Donnell, Christopher J; Jaff, Michael R; Murabito, Joanne M

    2014-03-01

    An increased interarm systolic blood pressure difference is an easily determined physical examination finding. The relationship between interarm systolic blood pressure difference and risk of future cardiovascular disease is uncertain. We described the prevalence and risk factor correlates of interarm systolic blood pressure difference in the Framingham Heart Study (FHS) original and offspring cohorts and examined the association between interarm systolic blood pressure difference and incident cardiovascular disease and all-cause mortality. An increased interarm systolic blood pressure difference was defined as ≥ 10 mm Hg using the average of initial and repeat blood pressure measurements obtained in both arms. Participants were followed through 2010 for incident cardiovascular disease events. Multivariable Cox proportional hazards regression analyses were performed to investigate the effect of interarm systolic blood pressure difference on incident cardiovascular disease. We examined 3390 (56.3% female) participants aged 40 years and older, free of cardiovascular disease at baseline, mean age of 61.1 years, who attended a FHS examination between 1991 and 1994 (original cohort) and from 1995 to 1998 (offspring cohort). The mean absolute interarm systolic blood pressure difference was 4.6 mm Hg (range 0-78). Increased interarm systolic blood pressure difference was present in 317 (9.4%) participants. The median follow-up time was 13.3 years, during which time 598 participants (17.6%) experienced a first cardiovascular event, including 83 (26.2%) participants with interarm systolic blood pressure difference ≥ 10 mm Hg. Compared with those with normal interarm systolic blood pressure difference, participants with an elevated interarm systolic blood pressure difference were older (63.0 years vs 60.9 years), had a greater prevalence of diabetes mellitus (13.3% vs 7.5%,), higher systolic blood pressure (136.3 mm Hg vs 129.3 mm Hg), and a higher total cholesterol

  11. Vene suurim teatrifestival tuleb! / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2005-01-01

    Vene draamafestivali "Kuldne mask" paremik 11.-16. oktoobrini Tallinnas. Tutvustatakse lavastusi - "Vennad ja õed" (lav. L. Dodin), "September. doc" (lav. M. Ugarov), "Oblom off" (M. Ugarov), "Kuningas Oidipus" (lav. A. Prikotenko)

  12. Viljandi paugutab kolme esietendusega / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Janusz Glowacki "Fortinbras jõi end täis" Viljandi Kultuuriakadeemia teatrikunsti eriala 6. lennu esituses, lavastaja Kalju Komissarov ja Sven Heiberg ; Ott Aardami "Börs ja börsitar" ja Henrik Ibseni "Nora/Maja", lavastaja Helen Rekkor

  13. Uus film tegi Raagist tegija / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2005-01-01

    Eesti Televisiooni fiktiivne dokumentaaldraama "August 1991" : stsenarist ja režissöör Ilmar Raag : produtsent Gerda Kordemets : operaator Janno-Hans Arro. Lisatud augustiputshi ajal teletorni kaitsnud Jüri Joosti ja Peeter Milli kommentaar

  14. Igavus teatris on igavaim igavus / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2004-01-01

    Läti teatri esindusfestivalist Riias. Lähemalt järgmistest lavastustest : R. Baumanise "Indranid" M. Gruzdovi lavastuses, J. Rainise "Puhu, tuul" G. Polishtshuki lavastuses, E. Siendze "Vasakpööre" O. Kordersi lavastuses ja E. Albee "Kes kardab Vurginia Woolfi?" R. Vaivarsi lavastuses

  15. Miks paisub Avignon viis korda? / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2006-01-01

    Avignoni teatrifestivali OFF-programmist. Pikemalt Bernard-Marie Koltési näidendi "La nuit juste avant les forets" lavastusest (trupp Compagnie Pourquoi) ja lavastusest "Mascarade" (trupp Viva La Commedia)

  16. Tantsud Tartus - vaatajast saab looja / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Festivalide Draama ja Eclectica tantsulavastustest : Krõõt Juuraku "Once Upon", Kaja Kannu, Martins Eiche ja Aigars Aipinsi "Vabadus/Briviba" ja Mairika Plakso ja Margus Toomla "The story of M & M Part II"

  17. Draamateater ja Theatrum Riias festivalil / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    1999-01-01

    Riias algas 25. okt. rahvusvaheline teatrifestival Homo Novus '99,kus Eestit esindavad Eesti Draamateater Priit Pedajase lavastusega "Mao tee kalju peal" ja Theatrum Lembit Petersoni lavastusega "Pelleas ja Melisande"

  18. Kaks vaadet Draamateatri "Kodukohale" / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2006-01-01

    Pakutakse kaks võimalust, kuidas kirjutada Draamateatri lavastusest "Kodukoht" Keila-Joa mõisas (arvustuste pealk. "Draamateater viib Keila-Joal võlumaailma" ja "Näide safe-bet-teatrist"). Mõlemad arvustuse tüübid mõnevõrra utreeritud

  19. Interaction by known beta cell loci on the association of antihypertensive drug therapies with hyperglycemia in the Framingham Offspring Study

    OpenAIRE

    Miguel y Yanes, José María de

    2013-01-01

    Antecedentes: Los polimorfismos de nucleótido simple (SNPs) comunes asociados a función de célula beta y la hipertensión o su tratamiento podrían interaccionar con la variación en el tiempo en la glucosa en ayunas (ΔGA) o la aparición de diabetes mellitus tipo 2 (DM-2). Métodos: Agrupamos datos de 3.471 participantes del Estudio Descendencia de Framingham en 6 períodos de ~4 años (15.852 personas-examen; edad media 52 años, 54% mujeres). Definimos tres exposiciones de hipertensión: 1) hiperte...

  20. Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study.

    Science.gov (United States)

    Li, Wenyuan; Dorans, Kirsten S; Wilker, Elissa H; Rice, Mary B; Ljungman, Petter L; Schwartz, Joel D; Coull, Brent A; Koutrakis, Petros; Gold, Diane R; Keaney, John F; Vasan, Ramachandran S; Benjamin, Emelia J; Mittleman, Murray A

    2017-09-01

    The objective of this study is to examine associations between short-term exposure to ambient air pollution and circulating biomarkers of systemic inflammation in participants from the Framingham Offspring and Third Generation cohorts in the greater Boston area. We included 3996 noncurrent smoking participants (mean age, 53.6 years; 54% women) who lived within 50 km from a central air pollution monitoring site in Boston, MA, and calculated the 1- to 7-day moving averages of fine particulate matter (diameterpollution was associated with higher levels of C-reactive protein, interleukin-6, and tumor necrosis factor receptor 2 but not fibrinogen or tumor necrosis factor α in individuals residing in the greater Boston area. © 2017 American Heart Association, Inc.

  1. Impact of age, sex, and indexation method on MR left ventricular reference values in the Framingham Heart Study offspring cohort.

    Science.gov (United States)

    Yeon, Susan B; Salton, Carol J; Gona, Philimon; Chuang, Michael L; Blease, Susan J; Han, Yuchi; Tsao, Connie W; Danias, Peter G; Levy, Daniel; O'Donnell, Christopher J; Manning, Warren J

    2015-04-01

    To determine normative values for left ventricular (LV) volumes, mass, concentricity, and ejection fraction (EF) and investigate associations between sex, age, and body size with LV parameters in community-dwelling adults. In all, 1794 Framingham Heart Study Offspring cohort members underwent LV short-axis oriented, contiguous multislice cine steady-state free precession MR of the left ventricle; from these a healthy referent group (n = 852, 61 ± 9 years, 40% men) free of clinical cardiac disease and hypertension (SBP 65 years); LV parameters were indexed to measures of body size. Men have greater LV volumes and mass than women both before and after indexation to height, powers of height, and body surface area (P J. Magn. Reson. Imaging 2015;41:1038-1045. © 2014 Wiley Periodicals, Inc. © 2014 Wiley Periodicals, Inc.

  2. Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study).

    Science.gov (United States)

    Guermazi, Ali; Niu, Jingbo; Hayashi, Daichi; Roemer, Frank W; Englund, Martin; Neogi, Tuhina; Aliabadi, Piran; McLennan, Christine E; Felson, David T

    2012-08-29

    To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity. Population based observational study. Community cohort in Framingham, MA, United States (Framingham osteoarthritis study). 710 people aged >50 who had no radiographic evidence of knee osteoarthritis (Kellgren-Lawrence grade 0) and who underwent MRI of the knee. Prevalence of MRI findings that are suggestive of knee osteoarthritis (osteophytes, cartilage damage, bone marrow lesions, subchondral cysts, meniscal lesions, synovitis, attrition, and ligamentous lesions) in all participants and after stratification by age, sex, body mass index (BMI), and the presence or absence of knee pain. Pain was assessed by three different questions and also by WOMAC questionnaire. Of the 710 participants, 393 (55%) were women, 660 (93%) were white, and 206 (29%) had knee pain in the past month. The mean age was 62.3 years and mean BMI was 27.9. Prevalence of "any abnormality" was 89% (631/710) overall. Osteophytes were the most common abnormality among all participants (74%, 524/710), followed by cartilage damage (69%, 492/710) and bone marrow lesions (52%, 371/710). The higher the age, the higher the prevalence of all types of abnormalities detectable by MRI. There were no significant differences in the prevalence of any of the features between BMI groups. The prevalence of at least one type of pathology ("any abnormality") was high in both painful (90-97%, depending on pain definition) and painless (86-88%) knees. MRI shows lesions in the tibiofemoral joint in most middle aged and elderly people in whom knee radiographs do not show any features of osteoarthritis, regardless of pain.

  3. Genome-wide association study of Lp-PLA(2 activity and mass in the Framingham Heart Study.

    Directory of Open Access Journals (Sweden)

    Sunil Suchindran

    2010-04-01

    Full Text Available Lipoprotein-associated phospholipase A(2 (Lp-PLA(2 is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of this enzyme are heritable traits, but major genetic determinants have not been explored in a systematic, genome-wide fashion. We carried out a genome-wide association study of Lp-PLA(2 activity and mass in 6,668 Caucasian subjects from the population-based Framingham Heart Study. Clinical data and genotypes from the Affymetrix 550K SNP array were obtained from the open-access Framingham SHARe project. Each polymorphism that passed quality control was tested for associations with Lp-PLA(2 activity and mass using linear mixed models implemented in the R statistical package, accounting for familial correlations, and controlling for age, sex, smoking, lipid-lowering-medication use, and cohort. For Lp-PLA(2 activity, polymorphisms at four independent loci reached genome-wide significance, including the APOE/APOC1 region on chromosome 19 (p = 6 x 10(-24; CELSR2/PSRC1 on chromosome 1 (p = 3 x 10(-15; SCARB1 on chromosome 12 (p = 1x10(-8 and ZNF259/BUD13 in the APOA5/APOA1 gene region on chromosome 11 (p = 4 x 10(-8. All of these remained significant after accounting for associations with LDL cholesterol, HDL cholesterol, or triglycerides. For Lp-PLA(2 mass, 12 SNPs achieved genome-wide significance, all clustering in a region on chromosome 6p12.3 near the PLA2G7 gene. Our analyses demonstrate that genetic polymorphisms may contribute to inter-individual variation in Lp-PLA(2 activity and mass.

  4. Remedial investigation/feasibility study for the David Witherspoon, Inc., 901 Site, Knoxville, Tennessee: Volume 2, Appendixes

    International Nuclear Information System (INIS)

    1996-10-01

    This document contains the appendixes for the remedial investigation and feasibility study for the David Witherspoon, Inc., 901 site in Knoxville, Tennessee. The following topics are covered in the appendixes: (A) David Witherspoon, Inc., 901 Site Historical Data, (B) Fieldwork Plans for the David Witherspoon, Inc., 901 Site, (C) Risk Assessment, (D) Remediation Technology Discussion, (E) Engineering Support Documentation, (F) Applicable or Relevant and Appropriate Requirements, and (G) Cost Estimate Documentation

  5. Remedial investigation/feasibility study for the David Witherspoon, Inc., 901 Site, Knoxville, Tennessee: Volume 2, Appendixes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    This document contains the appendixes for the remedial investigation and feasibility study for the David Witherspoon, Inc., 901 site in Knoxville, Tennessee. The following topics are covered in the appendixes: (A) David Witherspoon, Inc., 901 Site Historical Data, (B) Fieldwork Plans for the David Witherspoon, Inc., 901 Site, (C) Risk Assessment, (D) Remediation Technology Discussion, (E) Engineering Support Documentation, (F) Applicable or Relevant and Appropriate Requirements, and (G) Cost Estimate Documentation.

  6. Do Père David's deer lose memories of their ancestral predators?

    Directory of Open Access Journals (Sweden)

    Chunwang Li

    Full Text Available Whether prey retains antipredator behavior after a long period of predator relaxation is an important question in predator-prey evolution. Père David's deer have been raised in enclosures for more than 1200 years and this isolation provides an opportunity to study whether Père David's deer still respond to the cues of their ancestral predators or to novel predators. We played back the sounds of crows (familiar sound and domestic dogs (familiar non-predators, of tigers and wolves (ancestral predators, and of lions (potential naïve predator to Père David's deer in paddocks, and blank sounds to the control group, and videoed the behavior of the deer during the experiment. We also showed life-size photo models of dog, leopard, bear, tiger, wolf, and lion to the deer and video taped their responses after seeing these models. Père David's deer stared at and approached the hidden loudspeaker when they heard the roars of tiger or lion. The deer listened to tiger roars longer, approached to tiger roars more and spent more time staring at the tiger model. The stags were also found to forage less in the trials of tiger roars than that of other sound playbacks. Additionally, it took longer for the deer to restore their normal behavior after they heard tiger roars, which was longer than that after the trial of other sound playbacks. Moreover, the deer were only found to walk away after hearing the sounds of tiger and wolf. Therefore, the tiger was probably the main predator for Père David's deer in ancient time. Our study implies that Père David's deer still retain the memories of the acoustic and visual cues of their ancestral predators in spite of the long term isolation from natural habitat.

  7. E-tailing in Australia: A preliminary analysis of David Jones

    Directory of Open Access Journals (Sweden)

    Jun Xu

    2017-06-01

    Full Text Available Compared with other countries, especially China, United States, United Kingdom, Japan and Germany, Australiars online retail fall behind in terms of both its sale and percentage contribution to the total retail. This paper analyses David Jones, which is typical of large department store chains, and Australian e-tailing environment as a case study to identify enablers for and obstacle to the advancement of e-tailing in Australia. Based on the analysis, the paper provides David Jones with recommendations on internal improvement, supply chain, customer relationship, and adoption of emerging technologies. Future research will be conducted to investigate if the recommendations are also applicable for other Australian retailers.

  8. David I reimplantation procedure for aortic root replacement in Marfan patients: medium-term outcome.

    Science.gov (United States)

    Kari, Fabian A; Beyersdorf, Friedhelm; Rylski, Bartosz; Stephens, Elizabeth H; Russe, Maximilian; Siepe, Matthias

    2014-11-01

    Technical variations of the David reimplantation valve-sparing aortic root replacement (V-SARR) procedure have been proposed to be advantageous in patients with connective tissue disease, such as the Marfan syndrome (MFS). We report results of a Marfan cohort treated exclusively with the non-modified David I procedure. Forty-eight Marfan patients (25 males, mean age 33 ± 12 years, range 15-62 years) underwent the original variant of the David V-SARR (David I) between 1997 and 2013. Forty-two operations (88%) were performed as elective procedures for aortic root aneurysms and six for acute dissections (12%). Seventeen had aortic regurgitation (AR) grades ≥2+ preoperatively, and 3 had AR >2+. No patients with severe AR (4+) were selected for V-SARR. Three full or hemi-arch replacements were performed. Patients who were operated on using a variation of the David I or David II procedure were excluded. Mean prosthesis size was 28 ± 3 mm (18-30 mm). Mean clinical and echocardiographic follow-up (98% complete) was 3.8 ± 3.7 years with a cumulative follow-up of 178 patient-years. The early mortality rate was 2% (one hospital death). The survival rate was 98% (95% confidence 84-99%) at 4 years and 90% (57-98%) at 8 years with 5 patients at risk at 10 years. The rate of freedom from root or valve reoperation was 97% (79-99%) and 97% (79-99%) at 4 and 8 years, respectively. Only one patient required mechanical aortic valve replacement for progression of AR. Despite potential theoretical drawbacks of the David I V-SARR technique without neo-sinuses or a neo-sinotubular junction, it results in a favourable mid-term outcome in Marfan patients and compares well with reported results of different modifications of David V-SARR. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  9. Book reviews: Marsh David, The EURO – The Politics of the New Global Currency

    OpenAIRE

    Lazar, Isadora

    2011-01-01

    The EURO – The Politics of the New Global Currency, written by David Marsh and published in both English and German, is a very thorough chronicle of the birth of the European common currency, from its early days, almost half a century before, and of its development until nowadays and even beyond, as it includes considerations on short term dynamics. David Marsh describes the story of the euro in a very complex manner, through a detailed, comprehensive and up to date analysis of the gathered d...

  10. Validación de los modelos de predicción de Framingham y PROCAM como estimadores del riesgo cardiovascular en una población colombiana

    Directory of Open Access Journals (Sweden)

    Oscar M. Muñoz

    2014-07-01

    Conclusiones: La función de riesgo de Framingham debería usarse con precaución en población colombiana de riesgo bajo e intermedio sin historia previa de eventos cardiovasculares dado que sobrestima el riesgo y tiene baja capacidad de discriminación. La función de riesgo de PROCAM ajustada por sexo es una mejor opción para estimar el riesgo de enfermedad cardiovascular dura.

  11. In situ TEM nanoindentation and dislocation-grain boundary interactions : a tribute to David Brandon

    NARCIS (Netherlands)

    de Hosson, J.T.M.; Soer, W.A.; Minor, A.M.; Shan, Z.W.; Stach, E.A.; Asif, S.A.S.; Warren, O.L.

    2006-01-01

    As a tribute to the scientific work of Professor David Brandon, this paper delineates the possibilities of utilizing in situ transmission electron microscopy to unravel dislocation-grain boundary interactions. In particular, we have focused on the deformation characteristics of Al-Mg films. To this

  12. David Bohm and his work-on the occasion of his seventieth birthday

    International Nuclear Information System (INIS)

    Jammer, M.

    1988-01-01

    This biographical sketch of David Bohm summarizes his professional career, his relationships with Bohr, Einstein, Pauli, and other quantum theorists of his time, and discusses his published contributions to the fields of quantum mechanics, the refinement of the Schroedinger and Hamilton-Jacobi equations, the notion of hidden variables in particle observation and measure theory, and special relativity theory

  13. Käsitsi tegemise võlu / David Jones ; intervjueerinud Kai Lobjakas

    Index Scriptorium Estoniae

    Jones, David, 1953-

    2010-01-01

    10. Kohila keraamikasümpoosionil osalenud briti keraamik ja teoreetik David Jones endast, rakutehnikast, huvist põletamisega seonduvate teemade vastu, Kohila sümpoosioni raames tehtust, keraamika õpetamisest Inglismaal, käsitöö ja keraamika positsioonist praegu ja tulevikus jm.

  14. Apollo külastajate lemmikuks on Jan Kausi ja David Mitchelli raamatud / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2006-01-01

    Apollo kaupluse koduleheküljel valiti parimaks ilukirjandusteoseks Jan Kausi "Tema", tõlgitud ilukirjanduse osas David Mitchelli "Pilveatlas", luuleraamatutest Ott Arderi "Luule sünnib kus sünnib kui sünnib" ja lasteraamatutest Christopher Paolini "Vanem"

  15. Congo, de missie en de literatuur: Over David van Reybrouck, J. G. ...

    African Journals Online (AJOL)

    However, the travel books written by Lieve Joris and Bart Castelein and the play Missie (Mission) written by David van Reybrouck (2007) sketched a positive and nostalgic image of the missionary. Keywords: Dutch (post)colonial literature, Congo, missionaries, colonialism. Tydskrif vir Letterkunde Vol. 46 (1) 2009: pp. 123- ...

  16. The Archives of the History of American Psychology: An Interview with David B. Baker.

    Science.gov (United States)

    Prieto, Loreto R.

    2001-01-01

    Presents an interview with David B. Baker, Director of the Archives of the History of American Psychology. Covers topics such as: Baker's interest in the history of psychology, his work at the Archives of the History of American Psychology, and recommendations for teachers when addressing history in non-history courses. (CMK)

  17. The image of the blessed monarch, the Holy King of Georgia David the Builder

    Directory of Open Access Journals (Sweden)

    Efimov Vladimir Fedorovich

    2014-07-01

    Full Text Available The article considers the biography of the saint Georgian monarch, David the Builder, analyzes his actions, church, external and internal policy. Finally it draws a conclusion that all his life was dedicated to the service of God and neighbor. Thus, his life was a model of Christian Ministry, he occupied a responsible position in society.

  18. An Interview with David Rindskopf: A Leading Voice on Teaching Statistics and Methodology

    Science.gov (United States)

    Bembenutty, Hefer

    2011-01-01

    This article presents an interview with David Rindskopf, a Distinguished Professor of Educational Psychology and Psychology at the City University of New York Graduate Center, where he has taught since 1979. His research and teaching are in the area of applied statistics, measurement, and research design. He is a fellow of the American Statistical…

  19. Surnuist üles äratamine = Reviving the dead / David Crowley

    Index Scriptorium Estoniae

    Crowley, David, 1966-

    2012-01-01

    Eesti ekspositsioonist "Kui pikk on ühe maja elu?" 13. Venezia arhitektuuribiennaalil "Common Ground" (kuraator David Chipperfield). Tallinna Linnahalli minevikust ja praegusest olukorrast. Kuraator Tüüne-Kristin Vaikla, näituse autorid Urmo Vaikla, Tüüne-Kristin Vaikla, Ingel Vaikla, Maria Pukk, Ivar Lubjak, Veronika Valk. Saksa paviljoni näitusest "Reduce, reuse, recycle"

  20. On a Theme by Rene David: Comparative Law as "Technique Indispensable."

    Science.gov (United States)

    McAuley, Michael

    2002-01-01

    Explores a text by Rene David relating to the teaching of comparative law and the comparative teaching of law. Discusses bijural education as a way to comprehensively teach the civil and common law traditions. Addresses construction of a bijural curriculum and skills of comparative law teaching. (EV)

  1. David van der Linden, Experiencing Exile: Huguenot Refugees in the Dutch Republic 1680-1700

    Directory of Open Access Journals (Sweden)

    Matthew Glozier

    2016-04-01

    Full Text Available David van der Linden, Experiencing Exile: Huguenot Refugees in the Dutch Republic 1680-1700 (PhD Universiteit Utrecht 2013; Politics and Culture in Europe, 1650-1750; Farnham: Ashgate, 2015, xx + 289 pp., ISBN 978 14 7242 927 8.

  2. Education Policy, Globalization, Commercialization: An Interview with Bob Lingard by David Hursh

    Science.gov (United States)

    Hursh, David

    2017-01-01

    In this interview with David Hursh, Bob Lingard comments on his current and/or recently completed research projects in respect to new modes of global governance in schooling and the complementarity between international large scale assessments and national testing. He also looks at a project that, in conjunction with school leaders, teachers,…

  3. Forging Futures with Teens and Science Fiction: A Conversation with Greg Bear and David Brin.

    Science.gov (United States)

    Moltz, Sandy

    2003-01-01

    Presents an interview with Greg Bear and David Brin, two science fiction writers who started Reading for the Future, an international project geared toward secondary school students that shows teachers and librarians how science fiction inspires young readers. Discusses programs that have come out of this group; standards for books geared toward…

  4. Remapping Place and Narrative in Native American Literature: David Treuer's "The Hiawatha"

    Science.gov (United States)

    Kirwan, Padraig

    2007-01-01

    David Treuer's 1997 novel, "The Hiawatha," engages the traditional literary strategies employed by Native American writing, compares those strategies to earlier narratives (Native American and canonically American), offers a reassessment of indigenous novelistic structures, engages critical responses to tribal fiction, and does so in response to…

  5. Incorporating a Cross-Cultural Perspective in the Undergraduate Psychology Curriculum: An Interview with David Matsumoto.

    Science.gov (United States)

    Hill, G. William, IV

    2000-01-01

    Provides an interview with David Matsumoto, Professor of Psychology and Director of the Culture and Emotion Research Laboratory at San Francisco State University. He has studied emotion, human interaction, and culture for more than 15 years. Focuses on cross-cultural psychology and perspectives in relation to the psychology curriculum. (CMK)

  6. A Life in Research, an Adventure in Creativity: An Interview with David W. Chan

    Science.gov (United States)

    Henshon, Suzanna E.

    2011-01-01

    This article presents an interview with David W. Chan, founding director of the Program for the Gifted and Talented at the Chinese University of Hong Kong. Chan has worked at the university for nearly 30 years, first in the Department of Psychiatry and then in the Department of Educational Psychology. Currently, he is also an adjunct professor of…

  7. Don Davide Albertario propagandista antiebraico. L'accusa di omicidio rituale

    Directory of Open Access Journals (Sweden)

    Annalisa Di Fant

    2011-05-01

    Full Text Available The article analyses the leading role played by the priest/journalist Davide Albertario in the catholic antisemite propaganda of the late 19th century. He was director of "L'Osservatore Cattolico", a Milan-based daily paper belonging to the catholic press network controlled by the Vatican, that published many articles against the Jews, notably involving the blood libel.

  8. Simulating the Camp David Negotiations: A Problem-Solving Tool in Critical Pedagogy

    Science.gov (United States)

    McMahon, Sean F.; Miller, Chris

    2013-01-01

    This article reflects critically on simulations. Building on the authors' experience simulating the Palestinian-Israeli-American Camp David negotiations of 2000, they argue that simulations are useful pedagogical tools that encourage creative--but not critical--thinking and constructivist learning. However, they can also have the deleterious…

  9. Paul Voosen Receives 2013 David Perlman Award for Excellence in Science Journalism—News: Citation

    Science.gov (United States)

    Zaneski, Cyril T.

    2014-01-01

    It's my pleasure to nominate Paul Voosen, the former science reporter for Greenwire, for the David Perlman award. Last November, as Superstorm Sandy pounded the East Coast of the United States, Paul found himself stranded for several days in Miami, mourning a recently deceased family member.

  10. David Cronenberg ja William S. Burroughs kutsuvad teid lantshile / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    1999-01-01

    Mängufilm "Alasti eine" ("Naked Lunch") William S. Burroughs' teose järgi : režissöör ja stsenarist David Cronenberg : Suurbritannia - Kanada 1991. Lähemalt režissööri kohta. Ka Nädal nr. 35, lk. 29

  11. Inconvenient Truths: A Response to the Article by David Stoesz, "The Child Welfare Cartel"

    Science.gov (United States)

    Clark, James J.; Yegidis, Bonnie L.

    2016-01-01

    David Stoesz offers a sweeping critique of the Children's Bureau and social work education by claiming the existence of a "child welfare cartel." He also attacks the quality of social work education and research, which he claims has poorly invested government funding and helped create the unmitigated failures of the American child…

  12. David Douglas Duncan's Changing Views on War: An Audio-Visual Presentation.

    Science.gov (United States)

    Politowski, Richard

    This paper is the script for a slide presentation about photographer David Douglas Duncan and his view of war. It is intended to be used with slides made from pictures Duncan took during World War II, the Korean War, and the war in Viet Nam and published in various books and periodicals. It discusses a shift in emphasis to be seen both in the…

  13. "Who's Afraid of Secularisation?" A Response to David Lewin

    Science.gov (United States)

    Jackson, Robert

    2017-01-01

    This response to David Lewin states the purpose of my critique of some aspects of Liam Gearon's work. It clarifies my position on the aims of "inclusive" religious education, rejecting Gearon's view that REDCo researchers shared a common pluralistic theology, regarding religious education as having a single political aim. It reinforces…

  14. David Hockney’s Early Etchings: Going Transatlantic and Being British

    Directory of Open Access Journals (Sweden)

    Martin Hammer

    2017-05-01

    Full Text Available David Hockney’s early autobiographical prints, My Bonnie Lies Over the Ocean 1961 and the series A Rake’s Progress 1961–3, are examined in relation to contemporary developments in American art and literature, the artist’s affinities with his British modernist contemporaries and predecessors, and other aspects of his emerging sense of artistic and sexual identity.

  15. Framingham risk score for estimation of 10-years of cardiovascular diseases risk in patients with metabolic syndrome.

    Science.gov (United States)

    Jahangiry, Leila; Farhangi, Mahdieh Abbasalizad; Rezaei, Fatemeh

    2017-11-13

    There are a few studies evaluating the predictive value of Framingham risk score (FRS) for cardiovascular disease (CVD) risk assessment in patients with metabolic syndrome in Iran. Because of the emerging high prevalence of CVD among Iranian population, it is important to predict its risk among populations with potential predictive tools. Therefore, the aim of the current study is to evaluate the FRS and its determinants in patients with metabolic syndrome. In the current cross-sectional study, 160 patients with metabolic syndrome diagnosed according to the National Cholesterol Education Adult Treatment Panel (ATP) III criteria were enrolled. The FRS was calculated using a computer program by a previously suggested algorithm. Totally, 77.5, 16.3, and 6.3% of patients with metabolic syndrome were at low, intermediate, and high risk of CVD according to FRS categorization. The highest prevalence of all of metabolic syndrome components were in low CVD risk according to the FRS grouping (P metabolic syndrome and different FRS categorization among patients with metabolic syndrome were identified. High SBP and FSG were associated with meaningfully increased risk of CVD compared with other parameters. The study is not a trial; the registration number is not applicable.

  16. Changes in the food environment over time: examining 40 years of data in the Framingham Heart Study.

    Science.gov (United States)

    James, Peter; Seward, Michael W; James O'Malley, A; Subramanian, S V; Block, Jason P

    2017-06-24

    Research has explored associations between diet, body weight, and the food environment; however, few studies have examined historical trends in food environments. In the Framingham Heart Study Offspring (N = 3321) and Omni (N = 447) cohorts, we created food environment metrics in four Massachusetts towns utilizing geocoded residential, workplace, and food establishment addresses from 1971 to 2008. We created multilevel models adjusted for age, sex, education, and census tract poverty to examine trends in home, workplace, and commuting food environments. Proximity to and density of supermarkets, fast-food, full service restaurants, convenience stores, and bakeries increased over time for residential, workplace, and commuting environments; exposure to grocery stores decreased. The greatest increase in access was for supermarkets, with residential distance to the closest supermarket 1406 m closer (95% CI 1303 m, 1508 m) by 2005-2008 than in 1971-1975. Although poorer census tracts had higher access to fast-food restaurants consistently across follow-up, this disparity dissipated over time, due to larger increases in proximity to fast-food in wealthier neighborhoods. Access to most food establishment types increased over time, with similar trends across home, workplace, and commuter environments.

  17. A longitudinal analysis of the risk factors for diabetes and coronary heart disease in the Framingham Offspring Study

    Directory of Open Access Journals (Sweden)

    Bhargava Alok

    2003-04-01

    Full Text Available Abstract Background The recent trends in sedentary life-styles and weight gain are likely to contribute to chronic conditions such as hypertension, diabetes, and cardiovascular diseases. The temporal sequence and pathways underlying these conditions can be modeled using the knowledge from the biomedical and social sciences. Methods The Framingham Offspring Study in the U.S. collected information on 5124 subjects at baseline, and 8, 12, 16, and 20 years after the baseline. Dynamic random effects models were estimated for the subjects' weight, LDL and HDL cholesterol, and blood pressure using 4 time observations. Logistic and probit models were estimated for the probability of diabetes and coronary heart disease (CHD events. Results The subjects' age, physical activity, alcohol consumption, and cigarettes smoked were important predictors of the risk factors. Moreover, weight and height were found to differentially affect the probabilities of diabetes and CHD events; body weight was positively associated with the risk of diabetes while taller individuals had lower risk of CHD events. Conclusion The results showed the importance of joint modeling of body weight, LDL and HDL cholesterol, and blood pressure that are risk factors for diabetes and CHD events. Lower body weight and LDL concentrations and higher HDL levels achieved via physical exercise are likely to reduce diabetes and CHD events.

  18. Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study

    Directory of Open Access Journals (Sweden)

    Siyouneh Baghdasarian

    2018-05-01

    Full Text Available Identification of diet and lifestyle risk factors for prevention of type 2 diabetes mellitus (T2DM is of great importance. The specific role of dietary cholesterol (DC in T2DM risk is unclear. This study uses data from 2192 Framingham Offspring Study subjects to estimate the effects of DC alone and in combination with markers of a healthy diet and other lifestyle factors on fasting glucose and risk of T2DM or impaired fasting glucose (IFG over 20 years of follow-up. Dietary data were derived from two sets of three-day food records. Statistical methods included mixed linear regression and Cox proportional hazard’s modeling to adjust for confounding. There were no statistically significant differences in glucose levels over 20 years of follow-up across DC intake categories (<200, 200–<300, and ≥300 mg/day and no increased risk of T2DM/IFG associated with higher intakes. The HR for T2DM/IFG associated with consumption of ≥300 mg/day of DC was 0.87 (95% CI: 0.68–1.10. In contrast, subjects with lower intakes of fish, whole grains, and fiber had higher T2DM/IFG risk. DC consumption was not associated with fasting glucose levels or risk of T2DM/IFG over 20 years of follow-up.

  19. Characteristics Associated with Hallux Valgus in a Population-Based Study of Older Adults: The Framingham Foot Study

    Science.gov (United States)

    Dufour, Alyssa B.; Casey, Virginia A.; Golightly, Yvonne M.; Hannan, Marian T.

    2015-01-01

    Objective Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. Methods HV, foot pain, foot structure (planus, rectus, cavus), current and past high heel use, age, and body mass index were assessed in the population-based Framingham Foot Study. Sex-specific logistic and multinomial logistic regression examined the association of HV and HV with pain with study variables. Results Of 1352 men and 1725 women (mean age 66 ± 10.5 years), 22% of men and 44% of women had HV and 3% of men and 11% of women had HV with pain. Foot pain increased odds of HV in both sexes (p 30 kg/m2 decreased odds of HV by 33% in men and 45% in women (p<0.05). In women only, odds of Pain & HV vs. No Pain & No HV were greater with older age and planus foot structure. Conclusions Our work showed different associations in participants who had HV with pain compared to those without foot pain. In both men and women, strong relations were observed between HV and foot pain and inversely with BMI. Older age was associated with HV in women only, as were protective associations with cavus foot structure. PMID:24965070

  20. Comparison between the Framingham and prospective cardiovascular of Münster scores for risk assessment of coronary heart disease in human immunodeficiency virus-positive patients in Pernambuco, Brazil.

    Science.gov (United States)

    Barros, Zoraya Medeiros; de Alencar Ximenes, Ricardo Arraes; Miranda-Filho, Demócrito Barros; de Albuquerque, Maria de Fátima Pessoa Militão; Melo, Heloísa Ramos Lacerda; Carvalho, Erico Higino; Gelenske, Thais; Diniz, George; Bandeira, Francisco

    2010-12-01

    The Framingham score is used in most studies on human immunodeficiency virus (HIV)-positive patients to estimate the risk for coronary heart disease; however, it may have some limitations for detecting risk among these individuals. The aim of this study was to evaluate the agreement between the Framingham and Prospective Cardiovascular of Münster (PROCAM) scores among HIV-positive individuals and to investigate the factors associated with disagreement between the two scores. A cross-sectional study was conducted in a population of HIV/acquired immunodeficiency syndrome (AIDS) patients attending the outpatient's clinics of two reference centers for HIV/AIDS in Pernambuco, Brazil. Agreement between the Framingham and PROCAM scores was evaluated using the kappa index. From this analysis, a variable called "disagreement between scores" was created, and univariate and multivariate analysis were performed to investigate the factors associated with this variable. The prevalence of low, moderate, and high risk were, respectively, 78.7%, 13.5%, and 7.8% by Framingham score and 88.5%, 4.3%, and 7.2% by PROCAM (kappa = 0.64, P ≤ 0.0001). Agreement in the subgroup with metabolic syndrome by the International Diabetes Federation (IDF) (kappa = 0.51, P ≤ 0.0001) and the National Cholesterol Education Program (NCEP) (kappa = 0.59, P ≤ 0.0001) criteria was moderate. The Framingham score identified greater proportion of women with moderate risk. Factors independently associated with disagreement were: smoking, sex, age, low-density lipoprotein cholesterol, diastolic blood pressure, and metabolic syndrome. There was a good agreement between the Framingham and PROCAM scores in HIV-positive patients, but a higher proportion of moderate-high risk was identified by the Framingham score. This disagreement should be evaluated in cohort studies to observe clinical outcomes over the course of time.

  1. An Interview with David Dabydeen on Literature and Politics

    Directory of Open Access Journals (Sweden)

    Ruzbeh Babaee

    2016-07-01

    s rainforest, you will experience the sublime which contain elemental terror and a tragic sense of how life is constantly being destroyed and remade and destroyed by tooth and claw. [1] Ruzbeh Babaee [2] David Dabydeen

  2. Protective association of milk intake on the risk of hip fracture: results from the Framingham Original Cohort.

    Science.gov (United States)

    Sahni, Shivani; Mangano, Kelsey M; Tucker, Katherine L; Kiel, Douglas P; Casey, Virginia A; Hannan, Marian T

    2014-08-01

    Dairy foods are rich in bone-beneficial nutrients, yet the role of dairy foods in hip fracture prevention remains controversial. Our objective was to evaluate the association of milk, yogurt, cheese, cream, and milk + yogurt intakes with incident hip fracture in the Framingham Original Cohort. A total of 830 men and women from the Framingham Original Cohort, a prospective cohort study, completed a food-frequency questionnaire (1988 to 1989) and were followed for hip fracture until 2008. In this population-based study, Cox-proportional hazards regression was used to estimate hazard ratios (HR) by categories of energy-adjusted dairy intake (servings/wk), adjusting for standard confounders and covariates. The exposure was energy-adjusted intakes of milk, yogurt, cheese, cream, and milk + yogurt (servings/wk). Risk of hip fracture over the follow-up was the primary outcome; the hypothesis being tested was formulated after data collection. The mean age at baseline was 77 years (SD 4.9, range 68 to 96). Ninety-seven hip fractures occurred over the mean follow-up time of 11.6 years (range 0.04 to 21.9 years). The mean ± SD (servings/wk) of dairy intakes at baseline were: milk = 6.0 ± 6.4; yogurt = 0.4 ± 1.3; cheese = 2.6 ± 3.1; and cream = 3.4 ± 5.5. Participants with medium (>1 and milk intake tended to have lower hip fracture risk than those with low (≤1 serving/wk) intake (high versus low intake HR 0.58, 95% confidence interval [CI] 0.31-1.06, p = 0.078; medium versus low intake HR 0.61, 95% CI 0.36-1.08, p = 0.071; p trend = 0.178]. There appeared to be a threshold for milk, with 40% lower risk of hip fracture among those with medium/high milk intake compared with those with low intake (p = 0.061). A similar threshold was observed for milk + yogurt intake (p = 0.104). These associations were further attenuated after adjustment for femoral neck bone mineral density. No significant associations

  3. High prevalence of subclinical atherosclerosis in Brazilian postmenopausal women with low and intermediate risk by Framingham score.

    Science.gov (United States)

    Petisco, Ana Claudia Gomes Pereira; Assef, Jorge Eduardo; de Jesus, Carlos Alberto; Saleh, Mohamed Hassan; Barbosa, Jose Eduardo Martins; Costa de Souza Le Bihan, David; Pinto, Ibraim Masciarelli França; Rolim Fernandes Fontes Pedra, Simone; Barretto, Rodrigo Bellio de Mattos; Sousa, Amanda Guerra de Moraes Rego

    2017-03-01

    Cardiovascular diseases are the leading cause of mortality among women in several countries. Early detection of subclinical atherosclerosis (SA) could enable the adoption of preventive measures to avoid cardiovascular events. This study aimed to determine the prevalence of SA in Brazilian asymptomatic postmenopausal women in Framingham Risk Score (FRS) low and intermediate groups. Computed tomography (CT) and ultrasound (US) scans were performed in 138 asymptomatic postmenopausal women (56.1 ± 4.9 years of age) to survey for coronary artery and aortic calcification (CT scan) and assess carotid intima-media thickness (CIMT) and identify carotid plaques (US). The mean FRS was 2.64 ± 2.13 %. The prevalence of increased CIMT, carotid plaques, increased CIMT and/or plaques, coronary artery calcification (CAC) >0 and aortic calcification (AC) were, respectively, 45.7, 37.7, 62.3, 23.9 and 45.7 %. Normal imaging tests were found in 22.4 %. SA, defined as at least one abnormal imaging test, was associated with age, FRS, waist-to-rip ratio, systolic and diastolic blood pressure, HDL-c and ApoA1 levels, and ApoA1/ApoB ratio. In logistic regression, SA was associated with higher age (OR 1.108, 95 % CI 1.010-1.215, p = 0.029) and lower ApoA1 levels (OR 0.979, 95 % CI 0.960-0.998, p = 0.029). SA was prevalent in Brazilian postmenopausal women with low and intermediate risk groups (FRS) and was associated with higher age and lower levels of ApoA1. Carotid atherosclerosis was the most common presentation of SA in this group.

  4. Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study.

    Science.gov (United States)

    Preis, Sarah Rosner; Pencina, Michael J; Mann, Devin M; D'Agostino, Ralph B; Savage, Peter J; Fox, Caroline S

    2013-06-01

    Many studies of diabetes have examined risk factors at the time of diabetes diagnosis instead of considering the lifetime burden of adverse risk factor levels. We examined the 30-year cardiovascular disease (CVD) risk factor burden that participants have up to the time of diabetes diagnosis. Among participants free of CVD, incident diabetes cases (fasting plasma glucose ≥ 126 mg/dL or treatment) occurring at examinations 2 through 8 (1979-2008) of the Framingham Heart Study Offspring cohort were age- and sex-matched 1:2 to controls. CVD risk factors (hypertension, high LDL cholesterol, low HDL cholesterol, high triglycerides, obesity) were measured at the time of diabetes diagnosis and at time points 10, 20, and 30 years prior. Conditional logistic regression was used to compare risk factor levels at each time point between diabetes cases and controls. We identified 525 participants with new-onset diabetes who were matched to 1,049 controls (mean age, 60 years; 40% women). Compared with those without diabetes, individuals who eventually developed diabetes had higher levels of hypertension (odds ratio [OR], 2.2; P = 0.003), high LDL (OR, 1.5; P = 0.04), low HDL (OR, 2.1; P = 0.0001), high triglycerides (OR, 1.7; P = 0.04), and obesity (OR, 3.3; P < 0.0001) at time points 30 years before diabetes diagnosis. After further adjustment for BMI, the ORs for hypertension (OR, 1.9; P = 0.02) and low HDL (OR, 1.7; P = 0.01) remained statistically significant. CVD risk factors are increased up to 30 years before diagnosis of diabetes. These findings highlight the importance of a life course approach to CVD risk factor identification among individuals at risk for diabetes.

  5. Relation of Pericardial Fat, Intrathoracic Fat, and Abdominal Visceral Fat with Incident Atrial Fibrillation (From the Framingham Heart Study)

    Science.gov (United States)

    Lee, Jane J.; Yin, Xiaoyan; Hoffmann, Udo; Fox, Caroline S.; Benjamin, Emelia J.

    2016-01-01

    Obesity is associated with increased risk of developing atrial fibrillation (AF). Different fat depots may have differential associations with cardiac pathology. We examined the longitudinal associations between pericardial, intrathoracic, and visceral fat with incident AF. We studied Framingham Heart Study Offspring and Third Generation Cohorts who participated in the multi-detector computed tomography sub-study examination 1. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident AF. Body mass index (BMI) was included in the multivariable-adjusted model as a secondary adjustment. We included 2,135 participants (53.3% women; mean age 58.8 years). During a median follow-up of 9.7 years, we identified 162 cases of incident AF. Across the increasing tertiles of pericardial fat volume, age- and sex-adjusted incident AF rate per 1000 person-years of follow-up were 8.4, 7.5, and 10.2. Based on an age- and sex-adjusted model, greater pericardial fat [hazard ratio (HR) 1.17, 95% confidence interval (CI) 1.03-1.34] and intrathoracic fat (HR 1.24, 95% CI 1.06-1.45) were associated with increased risk of incident AF. The HRs (95% CI) for incident AF were 1.13 (0.99-1.30) for pericardial fat, 1.19 (1.01-1.40) for intrathoracic fat, and 1.09 (0.93-1.28) for abdominal visceral fat after multivariable adjustment. After additional adjustment of BMI, none of the associations remained significant (all p>0.05). Our findings suggest that cardiac ectopic fat depots may share common risk factors with AF, which may have led to a lack of independence in the association between pericardial fat with incident AF. PMID:27666172

  6. Do not fear the Framingham: Practical application to properly evaluate and modify cardiovascular risk in commercial divers.

    Science.gov (United States)

    Suresh, Rahul; Pavela, James; Kus, Marcus S; Alleman, Tony; Sanders, Robert

    2018-01-01

    In April 2016 the Association of Diving Contractors International (ADCI) consensus guidelines began recommending annual cardiovascular risk stratification of commercial divers using the Framingham Risk Score (FRS). For those at elevated risk, further testing is recommended. This approach has raised concerns about potential operational and financial impacts. However, the prevalence of elevated cardiovascular risk and need for additional testing among commercial divers is not known. Clinical data required to calculate the FRS was abstracted for 190 commercial divers in two cohorts. Population demographics, FRS distribution, contributions of risk factors and effect of interventions on reducing risk-factor burden were assessed. Mean FRS score was 1.68 ± 6.35 points, with 13 divers (6.8%) at intermediate risk and none at high 10-year risk. In these 13 divers, the mean contributions to the FRS were from age (6.5 points), cholesterol (3.1 pts.), smoking (1.3 pts.), highdensity lipoprotein (1 pt.), and systolic blood pressure (0.8 pts). The youngest age group had a significantly higher modifiable risk core than the oldest age group (5.87 vs. 1.2 points, P ⟨ 0.001). All 13 intermediate risk divers could have been reclassified as low-risk with successful treatment of modifiable risk factors. The prevalence of elevated cardiovascular risk among commercial divers is low, and treatment of modifiable risk factors could reclassify those at intermediate risk to low risk. Therefore, FRS implementation coupled with intensive risk-reduction strategies for at risk-divers may help improve diver health and prolong the careers of divers while limiting the need for additional testing and adverse operational impact. Copyright© Undersea and Hyperbaric Medical Society.

  7. Hallux Valgus and Lesser Toe Deformities are Highly Heritable in Adult Men and Women: the Framingham Foot Study

    Science.gov (United States)

    Hannan, Marian T.; Menz, Hylton B.; Jordan, Joanne M.; Cupples, L. Adrienne; Cheng, Chia-Ho; Hsu, Yi-Hsiang

    2013-01-01

    Objective To estimate heritability of three common disorders affecting the forefoot: hallux valgus, lesser toe deformities and plantar forefoot soft tissue atrophy in adult Caucasian men and women. Methods Between 2002-2008, a trained examiner used a validated foot exam to document presence of hallux valgus, lesser toe deformities and plantar soft tissue atrophy in 2,446 adults from the Framingham Foot Study. Among these, 1,370 participants with available pedigree structure were included. Heritability (h2) was estimated using pedigree structures by Sequential Oligogenic Linkage Analysis Routines (SOLAR) package. Results were adjusted for age, sex and BMI. Results Mean age of participants was 66 years (range 39 to 99 years) and 57% were female. Prevalence of hallux valgus, lesser toe deformities and plantar soft tissue atrophy was 31%, 29.6% and 28.4%, respectively. Significant h2 was found for hallux valgus (0.29 ~ 0.89, depending on age and sex) and lesser toe deformity (0.49 ~ 0.90 depending on age and sex). The h2 for lesser toe deformity in men and women aged 70+ years was 0.65 (p= 9×10−7). Significant h2 was found for plantar soft tissue atrophy in men and women aged 70+ years (h2 = 0.37; p=3.8×10−3). Conclusion To our knowledge, these are the first findings of heritability of foot disorders in humans, and they confirm the widely-held view that hallux valgus and lesser toe deformities are highly heritable in European-descent Caucasian men and women, underscoring the importance of future work to identify genetic determinants of the underlying genetic susceptibility to these common foot disorders. PMID:23696165

  8. Review of Sustainable Energy -- Without the Hot Air by David MacKay (2009

    Directory of Open Access Journals (Sweden)

    Kira Hamman

    2016-07-01

    Full Text Available David MacKay. Sustainable Energy: Without the hot air. (Cambridge, England: UIT Cambridge Ltd., 2009. 384 pp. ISBN 978-0954452933 (also available as a free e-book. Physicist David MacKay transforms what has historically been a debate fraught with skepticism and hysteria into an informed conversation. He does this by providing clear, accurate quantitative information on energy production and consumption in a form that allows comparison and invites thoughtful analysis. By recalibrating power into kilowatt-hours per day per person, he makes the numbers meaningful on an individual level. He then meticulously estimates the productive capacity of various renewable energy sources, explores alternative energy solutions, and ends with an array of concrete plans to get the planet off fossil fuels for good.

  9. Dialectical materialism and the construction of a new quantum theory: David Joseph Bohm, 1917-1992

    Energy Technology Data Exchange (ETDEWEB)

    Forstner, C.

    2005-07-01

    This paper touches on some general questions of theory construction in physics, by presenting a biographical case study of David Bohm through the perspective of Fleckian thought-collectives and their thought-style. In the 1920s a small elite of physicists established the Copenhagen Interpretation of quantum mechanics as a new thought-style in the thought-collective of the physicists. In the following decade the Copenhagen Interpretation was transferred from Europe to the USA, from one thought-collective into another, and was integrated into a specific American thought-style. David Bohm was initiated in this mode of thought during his undergraduate studies at the Pennsylvania State College and his graduate studies at Caltech and the University of California at Berkeley. (orig.)

  10. David Bowie’s Influence on JoJo’s Bizarre Adventure

    Directory of Open Access Journals (Sweden)

    Francesco-Alessio Ursini

    2017-03-01

    Full Text Available This article analyses the influence of David Bowie’s work in JoJo’s Bizarre Adventure, a manga known for its wealth of references to western popular culture. It is argued that David Bowie’s cultural reception can be attested via the presence of three narrative themes featuring in this manga series. The first theme is the exploration of diverse genres and an innovative, genre-defying attitude. The second theme is the use of avant-garde, flamboyant and gender-ambiguous aesthetics for its fictional characters. The third theme is a self-reflexive approach to the creation of fictional characters, intended as an awareness of the temporary, transient nature of their role as reluctant heroes in their own stories.

  11. Dialectical materialism and the construction of a new quantum theory: David Joseph Bohm, 1917-1992

    International Nuclear Information System (INIS)

    Forstner, C.

    2005-01-01

    This paper touches on some general questions of theory construction in physics, by presenting a biographical case study of David Bohm through the perspective of Fleckian thought-collectives and their thought-style. In the 1920s a small elite of physicists established the Copenhagen Interpretation of quantum mechanics as a new thought-style in the thought-collective of the physicists. In the following decade the Copenhagen Interpretation was transferred from Europe to the USA, from one thought-collective into another, and was integrated into a specific American thought-style. David Bohm was initiated in this mode of thought during his undergraduate studies at the Pennsylvania State College and his graduate studies at Caltech and the University of California at Berkeley. (orig.)

  12. Book reviews: Marsh David, The EURO – The Politics of the New Global Currency

    Directory of Open Access Journals (Sweden)

    Isadora Lazar

    2011-03-01

    Full Text Available The EURO – The Politics of the New Global Currency, written by David Marsh and published in both English and German, is a very thorough chronicle of the birth of the European common currency, from its early days, almost half a century before, and of its development until nowadays and even beyond, as it includes considerations on short term dynamics. David Marsh describes the story of the euro in a very complex manner, through a detailed, comprehensive and up to date analysis of the gathered data, making a substantial contribution to understanding the linkages between the political, historical, economic, financial, monetary, strategic and personal determinants of the evolution of the single currency.

  13. »Just cut them up like regular children.« : Eraserhead (USA 1977, David Lynch)

    OpenAIRE

    Höltgen, Stefan

    2010-01-01

    Zwischen 1970 und 1977 entsteht in fünfjähriger Dreharbeit mit Unterbrechungen und unter extrem schwierigen Produktionsbedingungen David Lynchs erster Spielfilm "Eraserhead". Vorbereitet wurde er in mehrfacher Hinsicht durch das Frühwerk des noch jungen Regisseurs. Seine kinetische Skulptur "Six Men getting sick", sowie seine Kurzfilme "The Alphabet" und "The Grandmother" verhalfen ihm nicht nur zu Stipendien (etwa der AFI für "The Grandmother"), sondern etablierten auch ein Motivinventar, au...

  14. J. David Creswell: Award for Distinguished Scientific Early Career Contributions to Psychology.

    Science.gov (United States)

    2014-11-01

    APA's Awards for Distinguished Scientific Early Career Contributions to Psychology recognize excellent young psychologists who have not held a doctoral degree for more than nine years. One of the 2014 award winners is J. David Creswell, for "outstanding and innovative research on mechanisms linking stress management strategies to disease." Creswell's award citation, biography, and a selected bibliography are presented here. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  15. Sidgwick’s Argument for Utilitarianism and his Moral Epistemology: A Reply to David Phillips

    OpenAIRE

    Skelton, Anthony

    2014-01-01

    David Phillips’s Sidgwickian Ethics is a penetrating contribution to the scholarly and philosophical understanding of Henry Sidgwick’s The Methods of Ethics. This note focuses on Phillips’s understanding of (aspects of) Sidgwick’s argument for utilitarianism and the moral epistemology to which he subscribes. In § I, I briefly outline the basic features of the argument that Sidgwick provides for utilitarianism, noting some disagreements with Phillips along the way. In § II, I raise some object...

  16. Review: Henry E. Brady & David Collier (Hrsg.) (2004). Rethinking Social Inquiry: Diverse Tools, Shared Standards

    OpenAIRE

    Catón, Matthias

    2006-01-01

    Das Buch Rethinking Social Inquiry, herausgegeben von Henry E. BRADY und David COLLIER, ist eine Antwort auf den Band von KING, KEOHANE und VERBA (1994), in dem versucht wird, Standards der quantitativen Forschung in der qualitativen Forschung einzuführen. Die Autoren des hier rezensierten Buchs kritisieren viele der Vorschläge, da sie argumentieren, dass qualitative Forschung anderer Werkzeuge bedürfe. Trotzdem stimmen sie zu, dass die Grundlagen des Forschungsaufbaus ähnlich sind. Das Buch ...

  17. Review: Henry E. Brady & David Collier (Eds.) (2004). Rethinking Social Inquiry: Diverse Tools, Shared Standards

    OpenAIRE

    Matthias Catón

    2006-01-01

    Das Buch Rethinking Social Inquiry, herausgegeben von Henry E. BRADY und David COLLIER, ist eine Antwort auf den Band von KING, KEOHANE und VERBA (1994), in dem versucht wird, Standards der quantitativen Forschung in der qualitativen Forschung einzuführen. Die Autoren des hier rezensierten Buchs kritisieren viele der Vorschläge, da sie argumentieren, dass qualitative Forschung anderer Werkzeuge bedürfe. Trotzdem stimmen sie zu, dass die Grundlagen des Forschungsaufbaus ähnlich sind. Das Buch ...

  18. Dr. David Brown poses with a portrait of Ronald McNair

    Science.gov (United States)

    1999-01-01

    In the gymnasium of Ronald McNair Magnet School in Cocoa, Fla., Dr. David Brown, a NASA astronaut, poses with a portrait of NASA astronaut Ronald McNair. The portrait was presented to the school by Walt Disney World during a tribute to McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  19. Multiple Brand Celebrity Endorsement: Případová studie David Beckham

    OpenAIRE

    Hiblerová, Adéla

    2017-01-01

    The Bachelor's Thesis on the topic of Multiple Brand Celebrity Endorsement: David Beckham Case Study focuses primarily on the issue of multiple endorsement of a number of brands by one celebrity. To be able to put this topic into perspective does this thesis begin with a description of celebrity endorsement as itself, defines 'celebrity', and also introduces various approaches towards cooperation of a celebrity and a brand in general. Consequently, reasons for and risks of such cooperation ar...

  20. A Gender Study or Shift Of Balance in David Mamet’s Oleanna

    OpenAIRE

    Kalay, Faruk

    2018-01-01

    One of the distinctive persons inAmerican literature and cinema, David Mamet writes a great number of plays andscripts and many of which are produced or directed by Mamet himself. Consistingof three acts and having minimalist characterization, Oleanna concerns aboutJohn, a faculty member in a university, and his female student Carol. Mamet primarilyquestions about capitalism, American education system and also tends to thesubjects of sexual harassment. Even though Mamet arguing about the rela...

  1. Inquiring into Appreciative Inquiry: A Conversation With David Cooperrider and Ronald Fry

    OpenAIRE

    Grieten, Styn; Lambrechts, Frank; Bouwen, René; Huybrechts, Jolien; Fry, Ronald; Cooperrider, David

    2018-01-01

    David Cooperrider and Ronald Fry are professors of Organizational Behavior at the Weatherhead School of Management, Case Western Reserve University. CWRU’s Department of Organizational Behavior is consistently acknowledged as one of the best in the world by the Financial Times. Together with their mentor, Suresh Srivastva, they created Appreciative Inquiry over 30 years ago. Since then, Appreciative Inquiry has been extensively applied world-wide, and many exciting results have been achieved ...

  2. Using optically scanned 3D data in the restoration of Michelangelo's David

    Science.gov (United States)

    Scopigno, Roberto; Cignoni, Paolo; Callieri, Marco; Ganovelli, Fabio; Impoco, G.; Pingi, P.; Ponchio, F.

    2003-10-01

    Modern 3D scanning technologies allow to reconstruct 3D digital representations of Cultural Heritage artifacts in a semi-automatic way, characterized by very high accuracy and wealth of details. The availability of an accurate digital representation opens several possibilities of utilization to experts (restorers, archivists, museum curators), or to ordinary people (students, museum visitors). 3D scanned data are commonly used for the production of animations, interactive visualizations, or virtual reality applications. A much more exciting opportunity is to use these data in the restoration of Cultural Heritage artworks. The integration between 3D graphic and restoration represents an open research field where many new supporting tools are required; the David restoration project has given several starting points and guidelines to the definition and development of innovative solutions. Digital 3D models can be used in two different but not subsidiary modes: as an instrument for the execution of specific investigations and as a supporting media for the archival and integration of all the restoration-related information, gathered with the different studies and analysis performed on the artwork. In this paper we present some recent work done in the framework of the Michelangelo's David restoration project. A 3D model of the David was reconstructed by the Digital Michelangelo Project, using laser-based 3D scanning technology. We have developed some tools to make those data accessible and useful in the restoration. Preliminary results are reported here together with some directions for further research.

  3. DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis

    Directory of Open Access Journals (Sweden)

    Baseler Michael W

    2007-11-01

    Full Text Available Abstract Background Due to the complex and distributed nature of biological research, our current biological knowledge is spread over many redundant annotation databases maintained by many independent groups. Analysts usually need to visit many of these bioinformatics databases in order to integrate comprehensive annotation information for their genes, which becomes one of the bottlenecks, particularly for the analytic task associated with a large gene list. Thus, a highly centralized and ready-to-use gene-annotation knowledgebase is in demand for high throughput gene functional analysis. Description The DAVID Knowledgebase is built around the DAVID Gene Concept, a single-linkage method to agglomerate tens of millions of gene/protein identifiers from a variety of public genomic resources into DAVID gene clusters. The grouping of such identifiers improves the cross-reference capability, particularly across NCBI and UniProt systems, enabling more than 40 publicly available functional annotation sources to be comprehensively integrated and centralized by the DAVID gene clusters. The simple, pair-wise, text format files which make up the DAVID Knowledgebase are freely downloadable for various data analysis uses. In addition, a well organized web interface allows users to query different types of heterogeneous annotations in a high-throughput manner. Conclusion The DAVID Knowledgebase is designed to facilitate high throughput gene functional analysis. For a given gene list, it not only provides the quick accessibility to a wide range of heterogeneous annotation data in a centralized location, but also enriches the level of biological information for an individual gene. Moreover, the entire DAVID Knowledgebase is freely downloadable or searchable at http://david.abcc.ncifcrf.gov/knowledgebase/.

  4. Milk and yogurt consumption are linked with higher bone mineral density but not with hip fracture: the Framingham Offspring Study.

    Science.gov (United States)

    Sahni, Shivani; Tucker, Katherine L; Kiel, Douglas P; Quach, Lien; Casey, Virginia A; Hannan, Marian T

    2013-01-01

    Dairy foods are a complex source of essential nutrients. In this study, fluid dairy intake, specifically milk, and yogurt intakes were associated with hip but not spine bone mineral density (BMD), while cream may adversely influence BMD, suggesting that not all dairy products are equally beneficial for the skeleton. This study seeks to examine associations of milk, yogurt, cheese, cream, most dairy (total dairy without cream), and fluid dairy (milk + yogurt) with BMD at femoral neck (FN), trochanter (TR), and spine, and with incident hip fracture over 12-year follow-up in the Framingham Offspring Study. Three thousand two hundred twelve participants completed a food frequency questionnaire (1991–1995 or 1995–1998) and were followed for hip fracture until 2007 [corrected]. Two thousand five hundred and six participants had DXA BMD (1996-2001). Linear regression was used to estimate adjusted mean BMD while Cox-proportional hazards regression was used to estimate adjusted hazard ratios (HR) for hip fracture risk. Final models simultaneously included dairy foods adjusting for each other. Mean baseline age was 55 (±1.6) years, range 26-85. Most dairy intake was positively associated with hip and spine BMD. Intake of fluid dairy and milk was related with hip but not spine BMD. Yogurt intake was associated with TR-BMD alone. Cheese and cream intakes were not associated with BMD. In final models, yogurt intake remained positively associated with TR-BMD, while cream tended to be negatively associated with FN-BMD. Yogurt intake showed a weak protective trend for hip fracture [HR(95%CI), ≤4 serv/week, 0.46 (0.21-1.03) vs. >4 serv/week, 0.43 (0.06-3.27)]. No other dairy groups showed a significant association (HRs range, 0.53-1.47) with limited power (n, fractures = 43). Milk and yogurt intakes were associated with hip but not spine BMD, while cream may adversely influence BMD. Thus, not all dairy products are equally beneficial for the skeleton. Suggestive fracture

  5. Hemoglobin A1c Is Positively Correlated with Framingham Risk Score in Older, Apparently Healthy Nondiabetic Korean Adults

    Directory of Open Access Journals (Sweden)

    Ji Hye Shin

    2013-06-01

    Full Text Available BackgroundSeveral studies have suggested that elevated levels of hemoglobin A1c (HbA1c are associated with cardiovascular disease (CVD in nondiabetic individuals. However, it is unclear whether HbA1c levels can serve as a simple screening marker for increased CVD risk in nondiabetic individuals. Our objective was to evaluate the relationship between HbA1c levels and CVD risk using the Framingham risk score (FRS in older, apparently healthy nondiabetic Korean adults.MethodsWe retrospectively studied 2,879 Korean adults between the ages of 40 and 79 who underwent voluntary health check-ups at the Health Promotion Center of our hospital from July 2009 to June 2011. Subjects were subdivided based on their HbA1c levels into four groups: tertiles within the HbA1c normal tolerance range and a group for subjects with an increased risk for diabetes (IRD.ResultsThe mean FRS for the upper tertile (9.6±3.8 group was significantly higher than that of the middle tertile (8.4±4.0 and lower tertile (7.6±3.8 groups. In addition, FRS was highest in the IRD group (10.5±3.7. Multiple linear regression analysis demonstrated that HbA1c levels exhibited a significant positive correlation with FRS when adjusted for confounding variables in all subjects (β±standard error [SE], 0.018±0.002; R2, 0.131, women (β±SE, 0.023±0.003; R2, 0.170, and men (β±SE, 0.016±0.004; R2, 0.109.ConclusionHbA1c levels were positively correlated with FRS in older, apparently healthy nondiabetic Korean adults. We propose that HbA1c levels may reflect CVD risk in nondiabetic individuals.

  6. Long-term results after aortic valve-sparing operation (David I).

    Science.gov (United States)

    Shrestha, Malakh; Baraki, Hassina; Maeding, Ilona; Fitzner, Sebastian; Sarikouch, Samir; Khaladj, Nawid; Hagl, Christian; Haverich, Axel

    2012-01-01

    Aortic valve-sparing David procedure has gained broad acceptance. However, few long-term results have been published. We present our results. More than 450 David procedures have been performed in our institution so far. Of these, 126 patients were operated between July 1993 and December 2000. Median age was 57 (8-83) years and 46 (36.5%) were female. As many as 26 (20.6%) had Marfan syndrome, 21 (16.7%) had acute aortic dissection type A (AADA) and 67 (53.2%) had additional procedures. There were six (4.8%) deaths in 30 post-operative period (POD), four of whom had AADA. In the follow-up, there were 32 (25.4%) late deaths, 11 (34.4%) of these were caused by cardiac or underlying disease or op-related. As many as 15 (11.9%) patients were re-operated; six (40%) were Marfan patients and two (13.3%) had early endocarditis. Follow-up echocardiography of 76 (60.3%) event-free patients showed valve insufficiency (AI)≤AI I° in 68 (89.5%) and grade II in 7 (9.2%) patients. Leaflet degeneration due to proposed leaflet contact with the straight Dacron graft was not observed. A total of 36 (47.4%) patients were in New York Heart Association (NYHA) class I, 33 (43.4%) in NYHA II, and five (6.6%) were in class III. During the entire follow-up of 790 patient-years, there was no stroke or major bleeding. Survival at 1, 5 and 10 years was 93%, 85% and 70%, respectively. Freedom from valve replacement at 1, 5 and 10 years was 96%, 91% and 87%, respectively. Regardless of the underlying pathology, valve-sparing David I procedure has acceptable long-term results. Valve-related complications such as stroke or major bleeding is exceedingly low.

  7. Long-term results after aortic valve-sparing operation (David I)†

    Science.gov (United States)

    Shrestha, Malakh; Baraki, Hassina; Maeding, Ilona; Fitzner, Sebastian; Sarikouch, Samir; Khaladj, Nawid; Hagl, Christian; Haverich, Axel

    2012-01-01

    OBJECTIVE Aortic valve-sparing David procedure has gained broad acceptance. However, few long-term results have been published. We present our results. METHODS More than 450 David procedures have been performed in our institution so far. Of these, 126 patients were operated between July 1993 and December 2000. Median age was 57 (8–83) years and 46 (36.5%) were female. As many as 26 (20.6%) had Marfan syndrome, 21 (16.7%) had acute aortic dissection type A (AADA) and 67 (53.2%) had additional procedures. RESULTS There were six (4.8%) deaths in 30 post-operative period (POD), four of whom had AADA. In the follow-up, there were 32 (25.4%) late deaths, 11 (34.4%) of these were caused by cardiac or underlying disease or op-related. As many as 15 (11.9%) patients were re-operated; six (40%) were Marfan patients and two (13.3%) had early endocarditis. Follow-up echocardiography of 76 (60.3%) event-free patients showed valve insufficiency (AI) ≤ AI I° in 68 (89.5%) and grade II in 7 (9.2%) patients. Leaflet degeneration due to proposed leaflet contact with the straight Dacron graft was not observed. A total of 36 (47.4%) patients were in New York Heart Association (NYHA) class I, 33 (43.4%) in NYHA II, and five (6.6%) were in class III. During the entire follow-up of 790 patient-years, there was no stroke or major bleeding. Survival at 1, 5 and 10 years was 93%, 85% and 70%, respectively. Freedom from valve replacement at 1, 5 and 10 years was 96%, 91% and 87%, respectively. CONCLUSIONS: Regardless of the underlying pathology, valve-sparing David I procedure has acceptable long-term results. Valve-related complications such as stroke or major bleeding is exceedingly low. PMID:21632258

  8. David a Goliáš: Narativní analýza 1S 17

    OpenAIRE

    Verzichová, Klára

    2013-01-01

    The task of diploma thesis "David and Goliath: A Narrative Analysis of 1 Samuel 17 ", is to analyze one of the most famous biblical stories through the methods of naratology and give a view on the text through various narrative categories. The greater part of this thesis will deal with exploring the characters, the dialogue, the role of the narrator, the implied reader, the events in the story, focalization and other categories. At the conclusion, there is a small excursus with a historical p...

  9. Calculating degree-based topological indices of dominating David derived networks

    Science.gov (United States)

    Ahmad, Muhammad Saeed; Nazeer, Waqas; Kang, Shin Min; Imran, Muhammad; Gao, Wei

    2017-12-01

    An important area of applied mathematics is the Chemical reaction network theory. The behavior of real world problems can be modeled by using this theory. Due to applications in theoretical chemistry and biochemistry, it has attracted researchers since its foundation. It also attracts pure mathematicians because it involves interesting mathematical structures. In this report, we compute newly defined topological indices, namely, Arithmetic-Geometric index (AG1 index), SK index, SK1 index, and SK2 index of the dominating David derived networks [1, 2, 3, 4, 5].

  10. Metamorfosis, ciencia y horror : en torno a La Mosca, de David Cronenberg (1986)

    OpenAIRE

    Sánchez-Biosca, Vicente

    1993-01-01

    A diferencia del resurgir animista que orienta buena parte de las películas de terror modernas, La mosca (David Cronenberg, 1986) presenta una convergencia entre los temas que ocupan a la biología y la genética y las fantasías de despedazamiento del cuerpo humano. Utilizando como soporte la idea de metamorfosis, La mosca se revela como fa cara despiadada de esa otra fantasía de cuerpos ligeros y bien formaados de la que nos habla la publicidad. La tesis de este artículo consiste en sostener q...

  11. Atomic processes and application in honour of David R. Bates' 60th birthday

    CERN Document Server

    Burke, P G

    2013-01-01

    Atomic Processes and Applications is a collection of review articles that discusses major atomic and molecular processes and their applications to upper atmospheric physics and to astrophysics. The book also serves as a 60th birthday tribute to Dr. David R. Bates. The coverage of the text includes the overview of stratospheric aeronomy; upper atmosphere of the earth; and problems in atmospheric pollution. The book also deals with technical and highly specialized issues including photoionization of atomic systems; atomic structure and oscillator strengths; and atomic scattering computations. Th

  12. Christopher R. Fee & David A. Leeming. Gods, Heroes, and Kings. The Battle for Mythic Britain

    Directory of Open Access Journals (Sweden)

    Sophie ALATORRE

    2006-06-01

    Full Text Available A reassessment of British mythology has long been overdue, and Gods, Heroes and Kings is to be regarded as a stimulating contribution which helps to situate Anglo-Saxon tales in the mainstream of Medieval literature. Myths, pagan and Judeo-Christian beliefs, classical narratives: such vast material forms the backcloth Christopher F. Fee and David A. Leeming have undertaken to explore, thanks to an erudite comparative approach. Obviously, their book first aims at giving readers a new image of ...

  13. Buhler, James. Neumeyer, David. Deemer, Rob. Hearing the Movies: Music and Sound in Film History

    Directory of Open Access Journals (Sweden)

    Carlos Henrique Silveira

    2012-05-01

    Full Text Available James Buhler et David Neumeyer sont certainement les auteurs les plus importants à publier sur l’analyse de la musique de film depuis les années quatre-vingt-dix aux Etats-Unis. Entre autres contributions, ils ont édité ensemble (avec Caryl Flinn Music and Cinema, un livre consacré aux différentes perspectives de l’étude de la musique de film. Tous les deux sont professeurs de théorie musicale à l’école de musique de l’université du Texas à Austin (Neumeyer étant aussi professeur à Leslie Wa...

  14. David Farber, The Rise and Fall of Modern American Conservatism: A Short History.

    Directory of Open Access Journals (Sweden)

    Giles Scott-Smith

    2010-11-01

    Full Text Available In the wake of the recent mid-term elections, this book makes interesting reading. David Farber's overall argument here, as emphasised by the title, is that conservatism as a recognisable political movement, ranging from Robert Taft in the 1930s through to George W. Bush in the 2000s, has entered a period of decline. This could be a strong dose of (academic, liberal wishful thinking, or, possibly, the author is on to something, but the American voter hasn’t realised it yet.The crucial point ...

  15. Dr. David Brown poses with students at Ronald McNair Middle School

    Science.gov (United States)

    1999-01-01

    Dr. David Brown (right), a NASA astronaut, poses with students in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. From left, the students are Kristin Rexford, Danitra Anderson, Dominique Smith, Fallon Davis, and Qiana Taylor. Brown was at the school to attend a tribute to NASA astronaut Ronald McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven, who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  16. Sesnando Davides - Alvazil, Cônsul, Estratega e Moçárabe

    OpenAIRE

    Isaac, Francisco Maria Botelho Barata

    2014-01-01

    Tese de mestrado, História, Universidade de Lisboa, Faculdade de Letras, 2014 Sesnando Davides, homem que governou a região de Coimbra durante a 2ª metade do século XI, é uma figura que permanece com diversas dúvidas por resolver. Pouco ou nada se sabe da sua proveniência, da sua educação ou ascensão dentro da corte de Leão e Castela, que lhe permitiu obter o governo da cidade de Coimbra, reconquistada em 1064 por Fernando I. Da governação de Sesnando chegaram-nos algumas notíc...

  17. The wonder of their voices: The 1946 Holocaust interviews of David Boder (New York: Oxford, 2010).

    Science.gov (United States)

    Rosen, Alan C

    2012-05-01

    Writing a study of psychologist David Boder's 1946 displaced persons (DP) interview project gave me a chance to further document the substantial early response to the Holocaust. This was clearly one important piece of my study, and one that was eminently straightforward. Yet much of the research on Boder's project at the point in time that I carried it out was elliptical, partly because the primary interview materials were coming to light at an astonishing pace, partly because the archive collections were virtually untapped, and partly because of the misconception of Boder and his interview project itself.

  18. David Hume e as Paixões Indiretas na Sociedade em Rede

    Directory of Open Access Journals (Sweden)

    Tiago Porto

    2017-02-01

    Full Text Available O presente artigo pretende trazer à discussão a importância da Teoria das Paixões desenvolvida por David Hume como um horizonte interpretativo para as ações dos indivíduos conetados às redes sociais da Internet. Para tanto, este trabalho abordará inicialmente o que conhecemos por sociedade em rede e o importante papel desempenhado pela Internet nessa configuração social; em seguida, analisaremos como as paixões indiretas influenciam os indivíduos conectados à rede internacional de computadores

  19. Representations of Reductive Groups : in Honor of the 60th Birthday of David A. Vogan, Jr.

    CERN Document Server

    Trapa, Peter

    2015-01-01

    Over the last forty years, David Vogan has left an indelible imprint on the representation theory of reductive groups.  His groundbreaking ideas have lead to deep advances in the theory of real and p-adic groups, and have forged lasting connections with other subjects, including number theory, automorphic forms, algebraic geometry, and combinatorics. Representations of Reductive Groups is an outgrowth of the conference of the same name, dedicated to David Vogan on his 60th birthday, which took place at MIT on May 19-23, 2014.  This volume highlights the depth and breadth of Vogan's influence over the subjects mentioned above, and point to many exciting new directions that remain to be explored.  Notably, the first article by McGovern and Trapa offers an overview of Vogan's body of work, placing his ideas in a historical context. Contributors: Pramod N. Achar, Jeffrey D. Adams, Dan Barbasch, Manjul Bhargava, Cédric Bonnafé, Dan Ciubotaru, Meinolf Geck, William Graham, Benedict H. Gross, Xuhua He, Jing-Son...

  20. Teorizando o mundo contemporâneo: Robert Brenner; Giovanni Arrighi; David Harvey

    Directory of Open Access Journals (Sweden)

    Moishe Postone

    2008-07-01

    Full Text Available O artigo busca apreender as profundas transformações sociais, políticas, econômicas e culturais que marcaram as três últimas décadas, em contraste com o período de prosperidade subseqüente à Segunda Guerra Mundial. Para tanto, o autor analisa criticamente três obras específicas que abordam o período: "The economics of global turbulence", de Robert Brenner, O longo século XX, de Giovanni Arrighi, e A condição pós-moderna, de David Harvey. O procedimento metateórico adotado permite apontar os requisitos de uma teoria crítica adequada ao capitalismo contemporâneo.The article aims to apprehend the deep social, political, economic and cultural transformations that characterized the three last decades, in contrast with the prosperity period following the Second World War. Therefore, the author critically analyses three specific works that deal with that period: "The economics of global turbulence", by Robert Brenner, The long Twentieth Century, by Giovanni Arrighi, and The conditions of postmodernity, by David Haravey. The metatheoric procedure adopted allows him to indicate the requisites of an adequate critical theory of contemporary capitalism.

  1. Corpses of Metaphor. Images of Death in David Leavitt and Jamaica Kincaid

    Directory of Open Access Journals (Sweden)

    Fiorenzo Iuliano

    2010-10-01

    Full Text Available This essay analyzes two works, My Brother by Jamaica Kincaid, and "Saturn Street" by David Leavitt, investigating the construction of homosexuality as a process accomplished by resorting to illness (AIDS and death. In both works, indeed, the slow and dramatic course of AIDS amounts to the progressive unveiling of homosexuality as a social threat or a cause of anxiety and repulsion. The two works are set in different contexts: whereas Jamaica Kincaid refers to the problematic situation of homosexuality in the Caribbean, David Leavitt explores the social and cultural scenario of the 1990s Los Angeles, in the wake of a by now ended utopian confidence in science and technology.  This comparative approach helps us understand the political dynamics through which, in different and, to some extents, opposite realities, the social stigma of AIDS worked as a means to construct homosexual identity and set it apart from the sanitized spectrum of normal and sanctioned sexual behaviors. The point I want to make in this essay is that the corpse is used as an effective metaphor for a dehumanized depiction of male homosexual and ill subjects.

  2. Has David Howden Vindicated Richard von Mises’s Definition of Probability?

    Directory of Open Access Journals (Sweden)

    Mark R. Crovelli

    2009-11-01

    Full Text Available In my recent article on these pages (Crovelli 2009 I argued that members of the Austrian School of economics have adopted and defended a faulty definition of probability. I argued that the definition of probability necessarily depends upon the nature of the world in which we live. I claimed that if the nature of the world is such that every event and phenomenon which occurs has a cause of some sort, then probability must be defined subjectively; that is, “as a measure of our uncertainty about the likelihood of occurrence of some event or phenomenon, based upon evidence that need not derive solely from past frequencies of ‘collectives’ or ‘classes.’” I further claimed that the nature of the world is indeed such that all events and phenomena have prior causes, and that this fact compels us to adopt a subjective definition of probability.David Howden has recently published what he claims is a refutation of my argument in his article “Single Trial Probability Applications: Can Subjectivity Evade Frequency Limitations” (Howden 2009. Unfortunately, Mr. Howden appears to not have understood my argument, and his purported refutation of my subjective definition consequently amounts to nothing more than a concatenation of confused and fallacious ideas that are completely irrelevant to my argument. David Howden has thus failed in his attempt to vindicate Richard von Mises’s definition of probability.

  3. The institution of science and the science of institutions the legacy of Joseph Ben-David

    CERN Document Server

    2014-01-01

    The present anthology, edited by Marcel Herbst, is partially based on a conference, held in 2009, to reflect on the legacy of Ben-David, and contains a selection of substantially revised papers, plus four contributions specifically written for this volume. The book focuses on three major lines of Ben-David’s research, namely “Center and Periphery” (Part I), “Role and Ethos” (Part II), and “Organization and Growth” (Part III). In addition, comprehensive introductory (“Prologue”) and concluding chapters (“Epilogue”, Part IV) by Marcel Herbst are provided. The volume addresses the following disciplines: higher education, history and sociology of science, philosophy of science, history of medicine, public administration, policy studies, Jewish studies, and economics. The anthology is one of two new publications on Joseph Ben-David after the special Minerva edition Vol. 25, Numbers 1–2, March 1987, and Gad Freudenthal’s collection of Ben-David’s writings [1991]. The text can be used i...

  4. Dinner at Orazio's--David Triggle the model of a mentor.

    Science.gov (United States)

    Smith, Susan L

    2015-11-15

    What does it mean to be a mentor in science? Definitions of mentorship are freely spouted in publications and include concepts such as academic support, professional development, role modeling, interaction, impartment of knowledge, evaluation of work, demonstration of methodology, etc. Perhaps most of us would agree with the duties listed. But just what does it mean, for example, to offer academic support? How might one facilitate professional development for a mentee? While we may agree to the general obligations of a mentor the specifics of what these entail would prove more controversial. This article will illustrate how easy it is to pick out a bad mentor. There are certain elements of conduct that, if practiced, undoubtedly put you in the "bad mentor" category. However, it is very difficult to explain just what it means to be not only an adequate mentor but also a stellar one. It may be easy to list the roles and responsibilities of a mentor but just how should they be performed/carried out? David Triggle is the model of an extraordinary mentor. The conclusion of this paper will focus on some specific mentorship activities David Triggle carried out that illustrate some of the intangible aspects of excellence in mentorship. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.

    Science.gov (United States)

    Jasuja, Guneet Kaur; Travison, Thomas G; Davda, Maithili; Murabito, Joanne M; Basaria, Shehzad; Zhang, Anqi; Kushnir, Mark M; Rockwood, Alan L; Meikle, Wayne; Pencina, Michael J; Coviello, Andrea; Rose, Adam J; D'Agostino, Ralph; Vasan, Ramachandran S; Bhasin, Shalender

    2013-06-01

    Age trends in estradiol and estrone levels in men and how lifestyle factors, comorbid conditions, testosterone, and sex hormone-binding globulin affect these age trends remain poorly understood, and were examined in men of the Framingham Heart Study. Estrone and estradiol concentrations were measured in morning fasting samples using liquid chromatography tandem mass spectrometry in men of Framingham Offspring Generation. Free estradiol was calculated using a law of mass action equation. There were 1,461 eligible men (mean age [±SD] 61.1±9.5 years and body mass index [BMI] 28.8±4.5kg/m(2)). Total estradiol and estrone were positively associated with age, but free estradiol was negatively associated with age. Age-related increase in total estrone was greater than that in total estradiol. Estrone was positively associated with smoking, BMI, and testosterone, and total and free estradiol with diabetes, BMI, testosterone, and comorbid conditions; additionally, free estradiol was associated negatively with smoking. Collectively, age, BMI, testosterone, and other health and behavioral factors explained only 18% of variance in estradiol, and 9% of variance in estrone levels. Men in the highest quintile of estrone levels had significantly higher age and BMI, and a higher prevalence of smoking, diabetes, and cardiovascular disease than others, whereas those in the highest quintile of estradiol had higher BMI than others. Total estrone and estradiol levels in men, measured using liquid chromatography tandem mass spectrometry, revealed significant age-related increases that were only partially accounted for by cross-sectional differences in BMI, diabetes status, and other comorbidities and health behaviors. Longitudinal studies are needed to confirm these findings.

  6. Concordancia entre las escalas de riesgo cardiovascular Procam y Framingham en varones que reciben tratamiento antirretroviral en un Hospital Nacional de Lima, Perú 2013

    Directory of Open Access Journals (Sweden)

    Patricia Lister-Del Pino

    Full Text Available Objetivos. Determinar la concordancia entre las escalas PROCAM (Prospective Cardiovascular Münster y Framingham en pacientes receptores de tratamiento antirretroviral. Materiales y métodos. Estudio transversal analítico en población masculina VIH positiva que recibe tratamiento antirretroviral en un hospital de referencia nacional en Lima, Perú. Para evaluar la concordancia entre ambas escalas se empleó el método gráfico de Bland y Altman, correlación con el coeficiente de Pearson y acuerdo entre pruebas mediante el coeficiente de Kappa. Resultados. Enrolamos 111 personas, con edad promedio de 47,0 años. La distribución de pacientes en riesgo cardiovascular bajo, moderado y alto fue de 81,2%, 13,6% y 5,4%, según PROCAM y de 71,2%, 25,2% y 3,6% según Framingham, respectivamente. Según el método de Bland y Altman, la concordancia fue adecuada en valores bajos y se fue perdiendo en riesgos altos. El coeficiente de Pearson mostró fuerte correlación (r=0,87 y p<0,05 y el coeficiente de Kappa fue de 0,56 (p<0,001. Conclusiones. La concordancia existente a riesgos bajos se va perdiendo a medida que el riesgo se va incrementando. Existe fuerte correlación entre ambas escalas. Se recomienda realizar más estudios que permitan conocer qué escala es la más óptima para ser utilizada en población adulta VIH positiva que recibe tratamiento antirretroviral

  7. EDITORIAL: Van der Waals interactions in advanced materials, in memory of David C Langreth Van der Waals interactions in advanced materials, in memory of David C Langreth

    Science.gov (United States)

    Hyldgaard, Per; Rahman, Talat S.

    2012-10-01

    sufficiently close to any corrugated—and/or any smooth—surface and thus enforce a strong vdW-type adhesion; it exploits what is then essentially a contact force (dominated by the attraction exerted in the near-surface regions) to defy the pull of gravity on its own bulk. This Journal of Physics: Condensed Matter special issue is dedicated to the memory of David C Langreth. David is a dearly missed friend and mentor who inspired many of us. He was an outstanding condensed matter theorist and a scholar who greatly influenced us through his many-particle-physics based insights into density functional theory (DFT), surface science and related areas. His seminal works range from conserving formulations of interacting nonequilibrium transport [1] and formal-scattering theory [2] to an explicit formulation [3] of the exact DFT exchange-correlation energy in the adiabatic connection formula (ACF), the latter also being derived independently by Gunnarsson and Lundqvist [4]. David's portfolio also includes an analysis [5] that helped catalyze and guide the development of DFT from the local-density approximation (LDA) to the formulations of generalized gradient approximations (GGAs). Another salient contribution of David's is in the area of vdW interactions in materials. He was a key architect of the vdW density functional (vdW-DF) method [6, 7]. This method was developed in a long-standing Rutgers-Chalmers collaboration between David's group and that of Bengt I Lundqvist, later extending to a wider group of researchers on both sides of the Atlantic. Plasmons are collective excitations that depend on electron-density variation. The plasmon response can be seen as defining the nature of the LDA [4] and their description can thus also be seen as contributing to the success of GGA. The vdW-DF method is a regular constraint-based density functional (for ground-state DFT) which is derived within the ACF framework and which emphasizes the electrodynamical nature of the coupling between

  8. Quantum mechanics in the cold war; Quantenmechanik im Kalten Krieg. David Bohm und Richard Feynman

    Energy Technology Data Exchange (ETDEWEB)

    Forstner, C.

    2007-07-01

    In the middle of the 20th century David Bohm and Richard Feynman developed two fundamentally different approaches of modern quantum mechanics: Bohm a realistic interpretation by means of hidden parameters and Feynman the path-integral formalism. This is by this more remarakable, because both physicists started from similar conditions and originated from similar connections. By its comparing approach this study presents more than a contribution to the history of the quantum theory. By the question for the social and cultural conditions of the formation of theories it is furthermore of science-sociological and science-theoretical interest. The in the beginning similar and later different binding of both scientists into the scientific community allows furthermore to study, which adapting pressure each group puts on the individual scientist and the fundamental parts of his research, and which new degrees of freedom in the formation of theories arise, when this constraint is cancelled.

  9. Work plan for the radiological survey for the David Witherspoon, Incorporated, Landfill-1630 site, Knoxville, Tennessee

    International Nuclear Information System (INIS)

    1996-07-01

    This work plan establishes the methods and requirements for performing a radiological survey at the David Witherspoon, Incorporated, Landfill-1630 Site, Knoxville, Tennessee (DWI 1630 Site) in accordance with requirements under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The radiological survey will identify the radiological contamination level of the equipment and debris stored at the DWI 1630 Site. The data generated from the survey activities will support the decisions for characterization of the equipment/debris and aid in subsequent disposition and waste handling. The survey activities to be performed under this work plan include an equipment radiological survey, a walkover survey, and an immunoassay testing for polychlorinated biphenyls (PCBs). This work plan includes a quality assurance (QA)/quality control (QC) project plan, a health and safety (H ampersand S) plan, and a waste management plan

  10. Professor Samuel David Gross (1805-1884) and His Innovations in Surgery and Medicine.

    Science.gov (United States)

    Laios, Konstantinos

    2018-06-01

    Professor Samuel David Gross (1805-1884) is considered as one of the founders of American surgery. He was a skillful surgeon who could excellently perform a lithotomy, an amputation, and a cataract surgery. He introduced many new surgical techniques and designed new surgical and medical instruments. He expertise was not limited to surgery alone; he also published studies concerning internal medicine, pathology, experimental physiology, and pharmacology. His most important treatise was his 2-volume work, A System of Surgery, Pathological, Diagnostic, Therapeutic and Operative (1861), which was a standard reference book in surgery in the United States during the second half of 19th century. Gross received many honors during his life. He was active in the operating room until his death.

  11. Commentary on "Asynchronous Preparation of Tonally Fused Intervals in Polyphonic Music" by David Huron

    Directory of Open Access Journals (Sweden)

    James Wright

    2008-05-01

    Full Text Available In his most recent contribution to an important and well-framed series of papers on auditory grouping and the perception of polyphonic music, David Huron seeks further evidence for his working hypothesis that J.S. Bach controls the employment of perfect consonances by desynchronizing their onsets, thereby inhibiting the perceptual fusion of polyphonic voices. However the more novel contribution of the present study would seem to be its demonstration that Bach also regulates the employment of dissonant tones by consistently desynchronizing their onsets. This finding provides the first concrete evidence for Wright and Bregman’s otherwise untested hypothesis that the control and salience of dissonance in polyphonic music are closely related to principles of auditory stream segregation (Wright, 1986; Wright & Bregman, 1987.

  12. Hacking the aesthetic: David Haines and Joyce Hinterding's new ecologies of signal

    Directory of Open Access Journals (Sweden)

    Andrew Murphie

    2012-06-01

    Full Text Available Award winning Australian electronic artists David Haines and Joyce Hinterding's installation work is discussed as “signal-work.” Their work reconfigures signal within original assemblages involving subtle audio, high resolution video (both recorded and animated, kilometers of coiled copper wire, antennae or home-built electronics, electrostatic disturbances, the like of very low frequency radiation from the Milky Way, and cross-signal processing. The article develops a context for thinking about the work in terms of Whitehead's process philosophy, as this is relevant to media theory, as well as concepts of plural ecology and ongoing differentiation drawn from Bateson and Guattari. Signal processing is seen as key to all this. The article argues that in Hinterding and Haines’ signal-work new sensations are produced, outside of the normal “syntax” of some models of aesthetic experience. This challenges some aspects of thinking about both aesthetics and political ecology.

  13. Emotional intelligence as an aspect of general intelligence: what would David Wechsler say?

    Science.gov (United States)

    Kaufman, A S; Kaufman, J C

    2001-09-01

    R. D. Roberts, M. Zeidner, and G. Matthews (2001) have carefully examined the controversial issue of whether emotional intelligence (EI) should be classified as an intelligence and whether EI's constructs meet the same psychometric standards as general intelligence's constructs. This article casts their efforts into the framework of both historical and modern IQ-testing theory and research. It details David Wechsler's attempts to integrate EI into his tests and how his conception of a good clinician would be that of an emotionally intelligent clinician. Current theories and research on IQ also have a role in EI beyond what Roberts et al. described, including J. L. Horn's (1989) expanded model and A. R. Luria's (1966) neuropsychological research, and better criteria than the Armed Services Vocational Aptitude Battery should be used in future EI studies. The authors look forward to more research being conducted on EI, particularly in future performance-based assessments.

  14. David M. Lubin. Shooting Kennedy : JFK and the Culture of Images.

    Directory of Open Access Journals (Sweden)

    François Brunet

    2006-04-01

    Full Text Available Voici un livre décapant, décoiffant et déroutant, qui a d’ores et déjà fait pas mal de bruit outre-Atlantique. Son auteur, David Lubin, enseigne l’histoire de l’art à Wake Forest (Caroline du Nord, et il était déjà connu des américanistes comme l’auteur de Picturing a Nation : Art and Social Change in Nineteenth-Century America (1994. Dans ce dernier livre, comme dans Titanic (1999, Lubin se montrait un historien de l’art novateur, voire iconoclaste, en organisant la confrontation des genr...

  15. The sociology of language in Johann David Michaelis's dissertation of 1760.

    Science.gov (United States)

    Smith, R N

    1976-10-01

    In 1759 Johann David Michaelis won a prize from the Prussian Royal Academy for his essay Beantwortung der Frage von dem Einfluss der Meinungen in die Sprache, und der sprache in die Meinungen. The essay was published in the following year and translated into French in 1762, into English in 1769, and into Dutch in 1771. The work has two major themes--linguistic relativity and language change--with ancillary discussions of language in general and of homonymy. Its most significant contribution to the theory of language is its discussion of linguistic relativity, especially in its manifestations in the influence of language on thought. Given the intellectual milieu of the work where inquiry was centered on the origin of language and language universals, it stands as one of the few discussions of this topic and it is also one of the most fruitful discussions of linguistic relativity for any period of history.

  16. Modeling Instruction of David Hestenes: a proposal of thematic modeling cycle and discussion of scientific literacy

    Directory of Open Access Journals (Sweden)

    Ednilson Sergio Ramalho de Souza

    2016-07-01

    Full Text Available The pedagogical work with mathematical modeling assumes investigate situations of reality. However, mental models formed from the contact with the experiential world are generally incompatible with the conceptual models. So David Hestenes supports the view that one of the biggest challenges of teaching and learning in science and mathematics is to coordinate conceptual models with mental models, which led to the elaboration of a didactic in mathematical modeling: Modeling Instruction. Our goal is to present a proposal for thematic modeling cycle drawn up in hestenesianos assumptions and discuss possibilities for scientific literacy. The main question was to know how to emerge indicators for scientific literacy for the proposed cycle. This is a bibliographic research in order to identify the available literature contributions on the subject and raise the possibility and challenges for the brazilian teaching science and mathematics. Preliminary results indicate that the proposed modeling cycle can develop indicators for scientific literacy of different natures.

  17. Work plan addendum for David Witherspoon, Inc., 901 Site Building Characterization, Knoxville, Tennessee

    International Nuclear Information System (INIS)

    1997-01-01

    This building characterization plan was developed as an addendum to the existing site characterization work plan documents, which are in Appendix B of the David Witherspoon, Inc., (DWI) preliminary remedial investigation (RI)/feasibility study (FS). All building characterization activities will be conducted in accordance with the rules of the Hazardous Substance Remedial Action Program under the direction of the Tennessee Department of Environment and Conservation, Division of Superfund (TN Rules 1200-1-3) and its implementing regulations. Additional rules of the state of Tennessee, Comprehensive Environmental Response, Compensation, and Liability Act of 1980, and the U.S. Environmental Protection Agency guidance were consulted during development of this plan. Activities at the DWI site were concerned with scrap metal processing and scrap metal resale

  18. Animals and nature: mapping storylines and metaphors in David Kramer’s narratives

    Directory of Open Access Journals (Sweden)

    M. Slabbert

    2011-06-01

    Full Text Available This article discusses the representation of animals and nature in selected lyrics from the oeuvre of singer, songwriter and producer David Kramer and considers his engagement with historical and contemporary discourses about human-animal and human-nature interaction in relation to ecological awareness within a South African context. I trace the socio-political commentary voiced through his depiction of animals in the folksongs he wrote during apartheid, especially in lyrics from the album “Baboondogs” (Kramer, 1986. Kramer also employs intertextual references to traditional South African folksongs and tales in his music. Furthermore, the social and environmental significance of Kramer’s representations of nature in a selection of his postapartheid lyrics is investigated. I argue that the pedagogical value of Kramer’s cultural commentary can contribute significantly to the challenge of teaching animal studies and ecocriticism in South African context.

  19. The Dehumanizing American Dream in David Mamet’s Glengarry Glen Ross

    Directory of Open Access Journals (Sweden)

    Mehdi Sepehrmanesh

    2014-01-01

    Full Text Available The American Dream is a recurrent theme in American literature. In this response, this paper is an attempt to expose the destructive effects of the dream on the human spirit. It is also shown, through the analysis of David Mamet’s glengarry Glen Ross, that despite the promise of the dream it contains many contradictions. Beneath the seeming simple surface of the play lies a deep current of meanings that reflect the calamities of modern American life, and in a broader sense, the modern world. This article indicates how capitalism inculcates ideologies in the mind of individuals in order to facilitate the exploiting process and unquestioning subordination. Ragged individualism, for instance, as  the most prominent of these ideologies, disrupts all communal bonds and even exceeds to the disintegration of friendship and family life.

  20. Remedial investigation/feasibility study for the David Witherspoon, Inc., 901 Site, Knoxville, Tennessee: Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    This remedial investigation (RI)/feasibility study (FS) supports the selection of remedial actions for the David Witherspoon, Inc. 901 Maryville Pike Site in Knoxville, Tennessee. Operations at the site, used as a recycling center, have resulted in past, present, and potential future releases of hazardous substances in to the environment. This Site is a Tennessee Superfund site. A phased approach was planned to (1) gather existing data from previous investigations managed by the Tenn. Dept. of Environment and Conservation; (2) perform a preliminary RI, including risk assessments, and an FS with existing data to identify areas where remedial action may be necessary; (3) gather additional field data to adequately define the nature and extent of risk-based contaminants that present identifiable threats to human and/or ecological receptors; and (4) develop remedial action alternatives to reduce risks to acceptable levels.

  1. Convergent validity test, construct validity test and external validity test of the David Liberman algorithm

    Directory of Open Access Journals (Sweden)

    David Maldavsky

    2013-08-01

    Full Text Available The author first exposes a complement of a previous test about convergent validity, then a construct validity test and finally an external validity test of the David Liberman algorithm.  The first part of the paper focused on a complementary aspect, the differential sensitivity of the DLA 1 in an external comparison (to other methods, and 2 in an internal comparison (between two ways of using the same method, the DLA.  The construct validity test exposes the concepts underlined to DLA, their operationalization and some corrections emerging from several empirical studies we carried out.  The external validity test examines the possibility of using the investigation of a single case and its relation with the investigation of a more extended sample.

  2. Memory, Identity and Desire: A Psychoanalytic Reading of David Lynch’s Mulholland Drive

    Directory of Open Access Journals (Sweden)

    Murat Akser

    2012-12-01

    Full Text Available This is a reading of David Mulholland Drive through psychoanalytic approach of Lacan from the perspective of formation of fantasy and shifting identities. Lynch constructs his films consciously choosing his themes from the sub(versive/conscious side of human mind. Previous attempts to read Lynch's films are fixed around the idea that Lynch is using film genres to create postmodern pastiches. Mulholland Drive has been analyzed several times from different approaches ranging from gender (Love, 2004, narratology (Lentzner, 2005; McGowan, 2004; Cook, 2011. Elements of film noir, musical, caper films can be identified in Lynch’s films. This detailed textual analysis intends to rationalize Lynch’s narrative structure through Lacanian terms in reference to Zizekian terminology.

  3. Pura Besakih. Temple, Religion and Society in Bali, David J. Stuart-Fox

    OpenAIRE

    Guermonprez, Jean-François

    2013-01-01

    Cet ouvrage est la thèse de doctorat soutenue en 1987 par l’un des meilleurs connaisseurs de Bali, David Stuart-Fox, à l’issue d’un très long séjour dans l’île où il aimait vivre, sans songer à engager une carrière universitaire qui ne l’attirait guère. Son objet d’étude, à peine effleuré par les auteurs orientalistes de la période coloniale, est le plus grand temple de l’île, Pura Besakih, à vrai dire un complexe de quatre-vingt-six sanctuaires situés sur les flancs du plus haut volcan de l’...

  4. The reconstitution of political theory: David Easton, behavioralism, and the long road to system.

    Science.gov (United States)

    Gunnell, John G

    2013-01-01

    During the last half of the twentieth century, the concept of system was arguably the most important concept in the theoretical repertoire of the discipline of American political science. Although systems analysis was broadly employed in the behavioral sciences, David Easton's work was particularly influential in the study of politics. This is in part because he attempted to develop a distinct account of the political system that was not theoretically subservient either to general systems theory or to conceptions of the social system such as that advanced by Talcott Parsons. Although a great deal of attention has been devoted to Easton's theory, the origins and evolution of the system concept in his work have not been carefully reconstructed and analyzed. © 2013 Wiley Periodicals, Inc.

  5. Review: Henry E. Brady & David Collier (Eds. (2004. Rethinking Social Inquiry: Diverse Tools, Shared Standards

    Directory of Open Access Journals (Sweden)

    Matthias Catón

    2006-03-01

    Full Text Available The book Rethinking Social Inquiry, edited by Henry E. BRADY and David COLLIER, is a response to a book by KING, KEOHANE and VERBA (1994 that aimed to introduce quantitative standards to qualitative research. The authors of the book reviewed here criticize many of the suggestions made there because they argue that qualitative research requires other tools. Nevertheless, they agree that the foundations of research design are similar. The book comprises a comprehensive critique of mainstream quantitative techniques, describes a set of qualitative tools for research, and addresses issues of how to combine qualitative and quantitative approaches to maximize analytical leverage. It is an excellent contribution to the methodological debate in the social sciences. URN: urn:nbn:de:0114-fqs0602309

  6. M-Polynomials and Topological Indices of Dominating David Derived Networks

    Directory of Open Access Journals (Sweden)

    Kang Shin Min

    2018-03-01

    Full Text Available There is a strong relationship between the chemical characteristics of chemical compounds and their molecular structures. Topological indices are numerical values associated with the chemical molecular graphs that help to understand the physical features, chemical reactivity, and biological activity of chemical compound. Thus, the study of the topological indices is important. M-polynomial helps to recover many degree-based topological indices for example Zagreb indices, Randic index, symmetric division idex, inverse sum index etc. In this article we compute M-polynomials of dominating David derived networks of the first type, second type and third type of dimension n and find some topological properties by using these M-polynomials. The results are plotted using Maple to see the dependence of topological indices on the involved parameters.

  7. Remedial investigation/feasibility study for the David Witherspoon, Inc., 901 Site, Knoxville, Tennessee: Volume 1

    International Nuclear Information System (INIS)

    1996-10-01

    This remedial investigation (RI)/feasibility study (FS) supports the selection of remedial actions for the David Witherspoon, Inc. 901 Maryville Pike Site in Knoxville, Tennessee. Operations at the site, used as a recycling center, have resulted in past, present, and potential future releases of hazardous substances in to the environment. This Site is a Tennessee Superfund site. A phased approach was planned to (1) gather existing data from previous investigations managed by the Tenn. Dept. of Environment and Conservation; (2) perform a preliminary RI, including risk assessments, and an FS with existing data to identify areas where remedial action may be necessary; (3) gather additional field data to adequately define the nature and extent of risk-based contaminants that present identifiable threats to human and/or ecological receptors; and (4) develop remedial action alternatives to reduce risks to acceptable levels

  8. Fairness and Respect in Obesity Prevention Policies: A Response to David Buchanan

    Directory of Open Access Journals (Sweden)

    Katherine King

    2014-01-01

    Full Text Available In his response to our article (1,2, David Buchanan introduces some useful and important distinctions in the concepts of equality and autonomy. He highlights, for example, the distinction between inequality and inequity, which captures the insight that not all differences between people are unjust. Unjust inequalities are a subset of differences between people, and theories of justice can be defined by how they determine which of these differences are unjust. In addition, he points out that autonomy is not simply a matter of negative liberty, but also about a positive capacity to act. This understanding of autonomy is consistent with the account we offered in the paper, which underlines the importance of both the capacity to understand available options, and the capacity to act on the choices that one makes.

  9. [Recurrent depressive disorder in Caspar David Friedrich. A pathographical approach with operationalized diagnosis].

    Science.gov (United States)

    Spitzer, C; Dahlenburg, B; Freyberger, H J

    2006-07-01

    Caspar David Friedrich (1774 - 1840) is one of the most important German Romantic painters. In his paintings, he prototypically represents the melancholy, which has been mentioned by his contemporaries and later biographers. Art scientists have also referred to his melancholy for the interpretation of his work. From a medical point of view, there are only two pathographies which remain inconclusive. Having applied diagnostic criteria for psychiatric disorders to his letters and publications, to statements of his contemporaries and to his art, we propose that he had suffered from a recurrent major depression which occurred in 1799 for the first time. At least three depressive episodes followed before he was struck by a stroke in 1835. There are epidemiological, psychodynamic and personality-typological reasons supporting our diagnostic assumption. The course of his depression corresponds to phases of reduced creativity, to the chosen techniques and motives. Finally we discuss the implications of our approach for the pathographical method in general.

  10. Rigoulet-Roze David, Géopolitique de l’Arabie Saoudite

    Directory of Open Access Journals (Sweden)

    Laurent Bonnefoy

    2007-12-01

    Full Text Available Depuis quelques années, l’Arabie Saoudite suscite un intérêt grandissant de la part des chercheurs et des experts occidentaux. Rares sont néanmoins les écrits qui à l’information collectée sur le terrain allient une démarche rigoureusement construite. C’est à juste titre que David Rigoulet-Roze rappelle dans son introduction la nécessité de dépasser les « lieux communs » et d’adopter « une perspective véritablement géopolitique, avec les outils et la méthode » (p. 8 que cela implique. Il est...

  11. Capitalismo, cidade e política na perspectiva de David Harvey

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Santana

    2013-06-01

    Full Text Available O texto discute alguns eixos conceituais relevantes para a compreensão da obra de David Harvey, concentrando-se especificamente nas formulações do autor acerca da ideia de rearranjo espacial (spatial fix, de novo imperialismo (new imperialism e de acumulação mediante despossessão (acumulation by dispossession. Objetiva-se lidar também com o que se seriam os componentes da teoria critica de Harvey. Além disso, apresenta-se como tais ideias e formulações não podem ser plenamente entendidas sem o seu enraizamento nas reflexões do autor acerca das cidades.

  12. The challenges and future of oral drug delivery: An interview with David Brayden.

    Science.gov (United States)

    Brayden, David J

    2016-12-01

    David Brayden speaks to Hannah Makin, Commissioning Editor: David Brayden is a Full Professor (Advanced Drug Delivery) at the School of Veterinary Medicine, University College Dublin (UCD) and also a Fellow of the UCD Conway Institute. Following a PhD in Pharmacology at the University of Cambridge, UK (1989), and a postdoctoral research fellowship at Stanford University, CA, USA, he set up Elan Biotechnology Research's in vitro pharmacology laboratory in Dublin (1991). At Elan, he became a senior scientist and project manager of several of Elan's joint-venture drug delivery research collaborations with US biotech companies. In 2001, he joined UCD as a lecturer in veterinary pharmacology and was appointed Associate Professor in 2006 and Full Professor in 2014. He was a Director of the Science Foundation Ireland Research Cluster (The Irish Drug Delivery Research Network) from 2007 to 2013, is a Deputy Coordinator of an FP7 Consortium on oral peptides in nanoparticles ('TRANS-INT', 2012-2017), and is a Co-Principal Investigator in 'CURAM', Science Foundation Ireland's new Centre for Medical Devices (2014-2020 [ 1 ]). He was made a Fellow of the Controlled Release Society in 2012. He is the author or co-author of >200 research publications and patents. D Brayden serves on the Editorial Advisory Boards of Drug Discovery Today, European Journal of Pharmaceutical Sciences, Advanced Drug Delivery Reviews and the Journal of Veterinary Pharmacology and Therapeutics, and is an Associate Editor of Therapeutic Delivery. D Brayden works as an independent consultant for drug delivery companies.

  13. David Roberts en Córdoba. Vistas de paisaje y arquitectura hacia 1833

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    Gámiz Gordo, Antonio

    2015-12-01

    Full Text Available David Roberts' views of Córdoba were carried out in 1833 and later redrafted as lithographs, engravings, and oils. These artworks enjoyed great commercial success and international diffusion due to their thematic and undoubted artistic value. The authors analyze their documentary value as a graphic record -prior to the advent of photography- of the urban landscape and architecture of Cordoba, a city now denominated a World Heritage Site. These images are studied here for the first time as a group, since they are either virtually untraceable or dispersed in museums throughout the world. In addition, these views have been contextualized with information concerning the artist and his Spanish journey, including a letter that he wrote from Córdoba. The documentary reliability of every image is also assessed, while the significant transformations of the places represented are indicated.Las vistas realizadas en Córdoba por David Roberts en 1833, reelaboradas como litografías, grabados y óleos, han gozado de gran éxito comercial y difusión internacional por su temática e indudable interés artístico. Esta investigación profundiza en su valor documental como registros gráficos previos a la aparición de la fotografía, del paisaje y la arquitectura de una ciudad hoy considerada Patrimonio de la Humanidad. Las imágenes presentadas se analizan por primera vez como conjunto, pues algunas son de difícil localización o están dispersas en museos de todo el mundo, y se contextualizan con datos sobre el pintor y su viaje por España, considerando una carta que éste escribió desde Córdoba. También se valora la fiabilidad documental de cada vista, a la vez que se detectan significativas transformaciones de los lugares representados.

  14. Repeating ice-earthquakes beneath David Glacier from the 2012-2015 TAMNNET array

    Science.gov (United States)

    Walter, J. I.; Peng, Z.; Hansen, S. E.

    2017-12-01

    The continent of Antarctica has approximately the same surface area as the continental United States, though we know significantly less about its underlying geology and seismic activity. In recent years, improvements in seismic instrumentation, battery technology, and field deployment practices have allowed for continuous broadband stations throughout the dark Antarctic winter. We utilize broadband seismic data from a recent experiment (TAMNNET), which was originally proposed as a structural seismology experiment, for seismic event detection. Our target is to address fundamental questions about regional-scale crustal and environmental seismicity in the study region that comprises the Transantarctic Mountain area of Victoria and Oates Land. We identify most seismicity emanating from David Glacier, upstream of the Drygalski Ice Tongue, which has been documented by several other studies. In order to improve the catalog completeness for the David Glacier area, we utilize a matched-filter technique to identify potential missing earthquakes that may not have been originally detected. This technique utilizes existing cataloged waveforms as templates to scan through continuous data and to identify repeating or nearby earthquakes. With a more robust catalog, we evaluate relative changes in icequake positions, recurrence intervals, and other first-order information. In addition, we attempt to further refine locations of other regional seismicity using a variety of methods including body and surface wave polarization, beamforming, surface wave dispersion, and other seismological methods. This project highlights the usefulness of archiving raw datasets (i.e., passive seismic continuous data), so that researchers may apply new algorithms or techniques to test hypotheses not originally or specifically targeted by the original experimental design.

  15. Q&A: A Conversation With David France - The HIV/AID Plague Years and Where We Stand Now.

    Science.gov (United States)

    Wehrwein, Peter

    2017-02-01

    Journalist David France's How to Survive A Plague is a searing firsthand account of the early years of the HIV/AIDS epidemic in New York City. AIDS activists, most of them gay men, were fighting for their lives. Researchers, politicians, public health officials, and pharma were slow to respond-or resisted outright.

  16. Religious Literacy or Spiritual Awareness? Comparative Critique of Andrew Wright's and David Hay's Approaches to Spiritual Education

    Science.gov (United States)

    Filipsone, Anta

    2009-01-01

    On the basis of a comparison of the educational approaches of Andrew Wright and David Hay this paper illustrates the persisting problem of dichotomising cognitive and trans-cognitive aspects of spiritual development and education. Even though both Wright and Hay speak of the same topic--spirituality and spiritual education--they define these terms…

  17. ‘A Wistful Dream of Far-Off Californian Glamour’: David Sylvester and the British View of American Art

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    James Finch

    2017-05-01

    Full Text Available David Sylvester’s criticism from the 1950s and 1960s combined enthusiasm for the vitality of new American art with ambivalence about its influence on British artists. This essay investigates Sylvester’s complex attitude towards American art through his writing, broadcasting and artist interviews.

  18. Aladdin Sane and Close-Up Eye Asymmetry: David Bowie’s Contribution to Comic Book Visual Language

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    Igor Juricevic

    2017-03-01

    Full Text Available In April 1973 David Bowie released 'Aladdin Sane'. The cover of 'Aladdin Sane' features an iconic image of David Bowie, a close-up shot of the artist with brightly colored orange hair and asymmetrical lightning bolt make-up on the right side of his face. This article argues that the cover image for 'Aladdin Sane' uses the Close-Up Eye Asymmetry (CUE-A pictorial device (i.e., close-up view of David Bowie, asymmetrical make-up around his eye and that CUE-A was adopted into Comic Book Visual Language by first providing evidence that CUE-A is used in comic book art. A link is then established between comic book art and music album art by showing that: (1 David Bowie was familiar with Comic Book Visual Language and could make a contribution to the language, and (2 comic book artists are influenced by music album art. I then make a case that the adoption of CUE-A into Comic Book Visual Language was specifically due to the cover image for 'Aladdin Sane' by analyzing: (1 the use of CUE-A by influential artists in the 1990s and (2 the different rates of adoption of CUE-A for the depiction of established versus newer comic book characters.

  19. Preserving Precious Instruments in Mathematics History: The Educational Museum of Teachers College and David Eugene Smith's Collection

    Science.gov (United States)

    Murray, Diane R.

    2011-01-01

    A history is given of the Educational Museum of Teachers College, which began in 1886, and David Eugene Smith's extensive collection of mathematical tools used in the Museum's exhibits is discussed. Historic mathematical instruments including, the astrolabe, abacus and counting rods, and the slide rule are examined. The author uses digitized…

  20. Measuring Success: David Conley's College Readiness Framework and the Illinois College and Career Readiness Act. In Brief

    Science.gov (United States)

    Baber, Lorenzo D.; Castro, Erin L.; Bragg, Debra D.

    2010-01-01

    The purpose of this brief is to understand the Illinois College and Career Readiness (CCR) Act in light of David Conley's college readiness model. Although not mentioned specifically by the Illinois statute, evaluation results gathered by the Office of Community College Research and Leadership (OCCRL) show alignment between a number of programs…

  1. Qualitative Research David Silverman Qualitative Research Sage Publications £26.99 464pp 9781849204170 1849204179 [Formula: see text].

    Science.gov (United States)

    2012-01-26

    DAVID SILVERMAN'S latest book builds on previous editions to provide up-to-date development in qualitative research and offers an overview of theoretical and practical considerations. Unlike many other qualitative research methodology books there is an emphasis on the function of qualitative research to articulate meaning.

  2. A Philosophical Analysis of David Orr's Theory of Ecological Literacy: Biophilia, Ecojustice and Moral Education in School Learning Communities

    Science.gov (United States)

    Mitchell, Debra B.; Mueller, Michael P.

    2011-01-01

    In his writings, David Orr claims that the US is in an "ecological crisis" and that this stems from a crisis of education. He outlines a theory of ecological literacy, a mode by which we better learn the ecology of the Earth and live in a sustainable manner. While emphasizing a shock doctrine, the diagnosis of "crisis" may be…

  3. The more I teach, the more I think the only thing that has any value is integrating skills : Interview with David Berkman

    NARCIS (Netherlands)

    Harris, Robert; Smids, Annejoke; Kors, Ninja

    2007-01-01

    In this interview David Berkman talks about many subjects, among them improvisation, and why classical musicians should improvise more. David Berkman: ‘I would say most Jazz musicians have a certain level of theoretical understanding of what they’re doing, and it’s probably higher than that of the

  4. «Always the photography astonishes me»: David Bowie, between myth and visual culture

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    Alessandra Olivares

    2016-11-01

    Full Text Available The recent death of David Bowie activated a memorial process which incites to retrace the cultural, social, aesthetic, of costume, fashion and art history of the last forty years. It’s impossible, therefore, not reflect on the mechanisms that led to the creation of he who in the collective imaginary is reductive to consider just a symbol of modern rock.Several books, prestigious magazines and important exhibitions devoted space to the infinite nuances of he who is defined not only icon but also idol, star, legend and myth. These terms have subtle interferences between them as Jean Jacques Wunenburger underlined and all refer to the concept of Mythology. Even if many authors stated the “disappearance of the myth” in the postmodern epoch (Jewett and Lawrence, the myth is one of those phenomena which involves the everyday life, also in the contemporary time.Certainly the ever closer relations between art, mass media and advertisement played a decisive role in restructuring the concept of myth, but didn’t essentially change its meaning. Actually, the mass reproducibility of images, instead of provoking the “fall of aura”, as stated by Walter Benjamin, seems to have increased the "sacred" magnetism of the images.The icon David Bowie is the result of a multifaceted and outstanding personality which involved and influenced every possible contemporary language - fashion, music, theatre, film, performance, video and more recently internet. As always the photographic gaze captured and crystallized over time the different visions making them eternal and “biting” in the meaning which Barthes clarified in his famous book.The intense collaboration with “the man who photographed the Seventies”, the English Mick Rock, produced images intended to write an important piece of the history of contemporary photography. Ziggy Stardust, the character masterfully interpreted and documented by Mick Rock, is the symbol of Bowie’s fascinating ability

  5. Hábitos Alimentares, Atividade Física e Escore de Risco Global de Framingham na Síndrome Metabólica

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    Thays Soliman Soares

    2014-04-01

    Full Text Available Fundamento: A síndrome metabólica é um transtorno complexo representado por um conjunto de fatores de risco cardiovascular. A adoção de um estilo de vida saudável está fortemente relacionada à melhora da Qualidade de Vida e interfere de forma positiva no controle dos fatores de risco presentes nessa condição clínica. Objetivo: Avaliar o efeito de um programa de modificação do estilo de vida sobre o Escore de Risco Cardiovascular Global de Framingham em indivíduos com síndrome metabólica. Método: Trata-se de uma subanálise de um ensaio clínico randomizado, controlado, cegado, com duração de três meses. Os participantes foram randomizados em quatro grupos: intervenção nutricional + placebo (INP, intervenção nutricional + suplementação de ácidos graxos ômega 3 (3 g/dia de óleo de peixe (INS3, intervenção nutricional + atividade física + placebo (INEP e intervenção nutricional + atividade física + suplementação de ácidos graxos ômega 3 (INES3. O Escore de Risco Cardiovascular Global de Framingham de cada indivíduo foi calculado antes e após a intervenção. Resultados: Participaram do estudo 70 indivíduos. Observou-se uma redução da média do escore após a intervenção de forma geral (p < 0,001. Obteve-se uma redução para risco intermediário em 25,7% dos indivíduos. Após a intervenção, observou-se redução significativa (p < 0,01 da "idade vascular", sendo esta mais expressiva nos grupos INP (5,2% e INEP (5,3%. Conclusão: Todas as intervenções propostas produziram efeito benéfico para a redução do escore de risco cardiovascular. O presente estudo reforça a importância da modificação do estilo de vida na prevenção e no tratamento das doenças cardiovasculares.

  6. David Price--Pioneer of digital ICP monitoring, neurosurgeon and teacher.

    Science.gov (United States)

    Czosnyka, Marek; Kirollos, Ramez; van Hille, Philip

    2015-06-01

    In early 1970s first personal desk-top computers started to be available in hospitals. Mr Price was one of the pioneers introducing his own software to identify Marmarou's model of CSF space during infusion studies to diagnose patients suffering from hydrocephalus. His closed-loop control system for infusion of mannitol to manage patients at risk of intracranial hypertension was designed in 1977. The system worked successfully for 10 years in Pinderfields Hospital in Wakefield, UK. In the middle 1980's he initiated international cooperation with Children's Health Centre in Poland in long-term computer-assisted monitoring and analysis of ICP. Software designed in a course of this cooperation paved the way for contemporary package of ICM+ (Intensive Care Monitor, University of Cambridge, UK). Our scientific portfolio from these years (1985-1995) contains hundreds of head injured patients with waveform ICP analysis, introduction of compensatory reserve index RAP, few highly cited papers. Now, we understand ICP much better thanks to David's personal passion and extremely friendly support.

  7. [Lessons learned from Magen David Adom's activities during the 2nd Lebanon War].

    Science.gov (United States)

    Rafalowski, Chaim; Peleg, Kobi; Bin, Eli

    2010-07-01

    The activities of Magen David Adom (MDA) during the 2nd Lebanese War led to a series of conclusions (some established during the fighting) regarding the operational concept of the organization, the response to the needs of the team members, and the resource requirements. The fighting led to an update in the operational concept, moving to the smaller based operational unit--the station, creating a flexible concept, enabling response to various simultaneous scenes, quickly generating a common situational awareness, and relocation of resources to the more relevant events. TechnoLogy must support the operational concept. The response to stress-related victims should be part of the operational concept during conflict. Debriefing and learning processes are part of the response and enable adaptation to the changing reality. A comprehensive response to the needs of the team members is required, by relocation of family members, meeting the daily needs and preventing stress-related reactions among them. A rotation of leave of absence, central management of human resources and the management of volunteers--spontaneous and those who return to active work, are other components of this issue. The required resources--personal protective equipment, collective protection, command control and communications equipment, the supplies level and the different vehicles required for the operation, are important issues in the operational program of the organization. Collecting blood, maintaining a strategic stockpile and protecting the units, are all part of MDA missions.

  8. Theory of Money of David Ricardo: Quantity Theory and Theory of Value

    Directory of Open Access Journals (Sweden)

    Susumu Takenaga

    2003-01-01

    Full Text Available En lo que es necesario enfatizar, al caracterizar la teoría cuantitativa de David Ricardo, es en que ésta es una teoría de determinación del valor del dinero en una situación particular en la cual se impide que el dinero, sin importar cual sea su forma, entre y salga libremente de la circulación. Para Ricardo, la regulación del valor del dinero por su cantidad es un caso particular en el cual el ajuste del precio de mercado al precio natural requiere un largo periodo de tiempo. La determinación cuantitativa es completamente inadmisible, pero solo cuando el período de observación es más corto que el de ajuste. En todo caso, la determinación del valor del dinero rara vez es vinculada a su teoría del valor de las mercancías. Contrario a la interpretación aceptada comúnmente, Ricardo no aplicó a la determinación del valor del dinero una teoría del valor distinta de aquélla aplicada a las mercancías en general.

  9. Review: David Lohmann (2003. Das Bielefelder Diakonie-Management-Modell [The Bielefeld Deaconry Management Model

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    Jürgen Rausch

    2006-01-01

    Full Text Available In six chapters, David LOHMANN makes suggestions for theological-ethical deaconry management, including a consideration of economic necessities. Through a qualitative comparison of documented sources, the author generates a theory of theological-ethical enterprise management. Following that, the author considers the theology of the deaconry in the context of TILLICH's model of believed realism and WICHERN’s theological concept of the inner mission. At the center of the examination lies a formulation of a cybernetic theory of deaconry theology. Of the available management models, the author favours the St. Galler model as the basic model of deaconry enterprise management. In doing so, the author lays out theological ground rules for the normative, strategic and operational levels of deaconry. In attempting to formulate this prospective deaconry management model through the consideration of the work of the two 20th century theologians and his own personal experience, the current needs and knowledge-base of specific deaconries are not considered. A systematic consideration of quantitative social research would have been a worthwhile supplement. In conclusion, the analysis develops a management model for deaconry enterprises that emphasizes the interdisciplinary aspects of theology and business economics. The book confirms the competitive value of a management model attuned to the theological and economic aspects of a deaconry. URN: urn:nbn:de:0114-fqs0601356

  10. El enigma de las montañas reales: propuesta narrativa de David Toscana

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    Iwona Kasperska

    2013-01-01

    Full Text Available The objective of this paper is to reflect on some features of David Toscana’s novel Los puentes de Königsberg. In this contribution by the Northern Mexican writer there are unusual parallelisms between different realities of the cities of Monterrey (Mexico and Königsberg (East Prussia, which become the basis of the structure of the novel. In this framework the author situates certain eccentric characters, providing them with a “double life”, a real Mexican one and an imaginary East-Prussian one, in order to contrast the cities and validate the superiority of Königsberg, the actual protagonist of the novel. Toscana uses selected criteria, such as scientific and cultural contributions by the cities, their different historical fates, and the moral attitudes of their inhabitants towards discrimination, war crimes and gender violence, which implies a severe critique of Monterrey’s society. The set of parallelisms between the cities is totally convincing as a fictional structure and emphasizes the most prominent quality of Toscana’s analysed prose.

  11. David J. Triggle: Medicinal chemistry, to pharmacology, calcium channels, and beyond.

    Science.gov (United States)

    Walker, Michael J A

    2015-11-15

    David Triggle's scientific career began as a chemist, went through medicinal chemistry into pharmacology, and finally on to somewhat more philosophical interests in later years. It was a career marked by many contributions to all of those aspects of science. Chief amongst his many contributions, in addition to those in medicinal chemistry, was his work on the drugs known as calcium ion channel blockers or (calcium antagonists). In the calcium ion channel field he was a particularly instrumental figure in sorting out the mechanisms, actions and roles of the class of calcium channel blockers, known chemical and pharmacologically as the dihydropyridines (DHPs) in particular, as well as other calcium blockers of diverse structures. During the course of a long career, and extensive journeys into medicinal chemistry and pharmacology, he published voluminously in terms of papers, reviews, conference proceedings and books. Notably, many of his papers often had limited authorship where, as senior author it reflected his deep involvement in all aspects of the reported work. His work always helped clarify the field while his incisive reviews, together with his role in coordinating and running scientific meetings, were a great help in clarifying and organizing various fields of study. He has had a long and illustrious career, and is wellknown in the world of biomedical science; his contributions are appreciated, and well recognized everywhere. The following article attempts to chart a path through his work and contributions to medicinal chemistry, pharmacology, science, academia and students. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. EN LA TEORÍA ECONÓMICA DE DAVID RICARDO

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    FRANCISCO CORREA RESTREPO

    2015-01-01

    Full Text Available Este artículo tiene como objetivo central analizar el papel del recurso tierra en la teoría económica de David Ricardo como primer acercamiento al análisis económico de los recursos naturales. Esto se realiza mediante una revisión bibliográfica analítica de la obra de Ricardo y de otros autores en torno a la misma. En este sentido, se examina el concepto de renta de la tierra, así como los planteamientos en torno a la llamada ley de los rendimientos decrecientes. Asimismo, se establecen algunas reflexiones críticas con relación al enfoque de la renta de la tierra. Un resultado importante del trabajo es que en el análisis de la renta de Ricardo está ausente el concepto de costo de oportunidad, lo cual implica una reconsideración del concepto de renta para abordar el análisis económico de recursos naturales.

  13. David Stafford-Clark (1916-1999): Seeing through a celebrity psychiatrist.

    Science.gov (United States)

    Miller, Gavin

    2017-04-26

    This article uses the mass-media career of the British psychiatrist David Stafford-Clark (1916-1999) as a case study in the exercise of cultural authority by celebrity medical professionals in post-war Britain. Stafford-Clark rose to prominence in the mass media, particularly through his presenting work on medical and related topics for BBC TV and Radio, and was in the vanguard of psychiatrists and physicians who eroded professional edicts on anonymity. At the height of his career, he traded upon his celebrity status, and consequent cultural authority, to deliver mass media sermons on a variety of social, cultural, and political topics. Stafford-Clark tried to preserve his sense of personal and intellectual integrity by clinging to a belief that his authority in the public sphere was ultimately to be vindicated by his literary, intellectual, and spiritual significance. But as his credibility dwindled, he came to distrust the cultural intermediaries, such as broadcasters and publishers, who had supported him.

  14. David Matza: perspectiva criminológica de la deriva a la delincuencia juvenil

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    Omar Huertas Díaz

    2016-12-01

    Full Text Available El fenómeno de la delincuencia juvenil es un tema que aún en la actualidad sigue generando polémica; las líneas de investigación enfocan su esfuerzo en la búsqueda de las razones por las cuales un menor entra en el mundo delincuencial. Sin embargo, omiten la existencia de autores que dedicaron sus estudios a dar respuesta a tal cuestión. Un autor clave en el estudio del fenómeno delincuencial es el sociólogo estadounidense David Matza, pionero en las teorías de carácter social que pretenden dar respuestas a las incógnitas planteadas dentro de la temática juvenil; el presente artículo se enfocará en el análisis y reflexión de los principales postulados de su teoría de las subculturas delincuenciales, por medio de una perspectiva basada en la interacción, lo cual nos mostrará que es una subcultura a la par de la cultura convencional, con miembros que no distan de aquellos jóvenes que son considerados normales por la mayoría de la sociedad. Así se explica por qué algunos jóvenes se aproximan al quebrantamiento de la ley.

  15. Clássicos versus Keynes: a abordagem formal de David Champernowne

    Directory of Open Access Journals (Sweden)

    Cláudia Heller

    2012-03-01

    Full Text Available Este texto tem por objetivo ressaltar um aspecto que não tem sido tratado com a devida profundidade na literatura que estuda a formalização da Teoria Geral do Emprego, dos Juros e da Moeda de John Maynard Keynes (1936. Mais precisamente, o texto destaca a estratégia de formalização adotada por David G. Champernowne em seu artigo intitulado "Unemployment, Basic and Monetary: the classical analysis and the keynesian", publicado em 1935-36 na Review of Economic Studies. Chamamos a atenção para o fato dele distinguir a teoria clássica da teoria de Keynes não apenas pelos pressupostos adotados por cada teoria, mas principalmente pela construção de subsistemas a partir de um sistema geral, com características recursivas (relações de causalidade distintas. As explicações "em prosa", a descrição algébrica das funções comportamentais e condições de equilíbrio e a ilustração por meio de diagramas, além da escolha de conjuntos específicos de variáveis para representar cada uma das teorias e suas diferentes versões são aspectos deste artigo de Champernowne que merecem uma análise mais minuciosa.

  16. Response to the Point of View of Gregory B. Pauly, David M. Hillis, and David C. Cannatella, by the Anuran Subcommittee of the SSAR/HL/ASIH Scientific and Standard English Names List

    Science.gov (United States)

    Frost, Darrel R.; McDiarmid, Roy W.; Mendelson, Joseph R.

    2009-01-01

    The Point of View by Gregory Pauly, David Hillis, and David Cannatella misrepresents the motives and activities of the anuran subcommittee of the Scientific and Standard English Names Committee, contains a number of misleading statements, omits evidence and references to critical literature that have already rejected or superseded their positions, and cloaks the limitations of their nomenclatural approach in ambiguous language. Their Point of View is not about promoting transparency in the process of constructing the English Names list, assuring that its taxonomy is adequately reviewed, or promoting nomenclatural stability in any global sense. Rather, their Point of View focuses in large part on a single publication, The Amphibian Tree of Life, which is formally unrelated to the Standard English Names List, and promotes an approach to nomenclature mistakenly asserted by them to be compatible with both the International Code of Zoological Nomenclature and one of its competitors, the PhyloCode.

  17. HeartCare+: A Smart Heart Care Mobile Application for Framingham-Based Early Risk Prediction of Hard Coronary Heart Diseases in Middle East

    Directory of Open Access Journals (Sweden)

    Hoda Ahmed Galal Elsayed

    2017-01-01

    Full Text Available Background. Healthcare is a challenging, yet so demanding sector that developing countries are paying more attention to recently. Statistics show that rural areas are expected to develop a high rate of heart diseases, which is a leading cause of sudden mortality, in the future. Thus, providing solutions that can assist rural people in detecting the cardiac risks early will be vital for uncovering and even preventing the long-term complications of cardiac diseases. Methodology. Mobile technology can be effectively utilized to limit the cardiac diseases’ prevalence in rural Middle East. This paper proposes a smart mobile solution for early risk detection of hard coronary heart diseases that uses the Framingham scoring model. Results. Smart HeartCare+ mobile app estimates accurately coronary heart diseases’ risk over 10 years based on clinical and nonclinical data and classifies the patient risk to low, moderate, or high. HeartCare+ also directs the patients to further treatment recommendations. Conclusion. This work attempts to investigate the effectiveness of the mobile technology in the early risk detection of coronary heart diseases. HeartCare+ app intensifies the communication channel between the lab workers and patients residing in rural areas and cardiologists and specialist residing in urban places.

  18. KONTROVERSI HUKUMAN MATI ANALISIS WACANA SASTRA KRITIS THE LIFE OF DAVID GALE FILM PERSPEKTIF SOCIOCULTURAL PRACTICE NORMAN FAIRCLOUGH

    Directory of Open Access Journals (Sweden)

    Abd Ghofur

    2017-05-01

    Full Text Available This article is written in order to explain and to explore the hidden message contained in The Life of David Gale film, it is also to find out the reasons of the figures of Clearance and David Gale who deliberately sacrifice themselves [commit suicide] for an ideology that was fought by them, as well as try to uncover the ideology of the ruler who so impose a sentence of death in the name of justice, The theory of discourse analysis Norman Fairclough used by the writer to explain the hidden meaning in the text of [speech] contained in the film. Further, it was found that in the film the figures of Clearance with the deliberately suicidal, as part of efforts to prove that during this time the ruler of the [read: of the court] in giving a decision.

  19. A REVIEW OF ENGLISH TEXTBOOK ENTITLED "SKILLFUL: READING AND WRITING, STUDENT'S BOOK 1" BY DAVID BOHLKE AND DOROTHY ZEMACH

    OpenAIRE

    Thunyalak Polsuk; Nutprapha K. Dennis, Ph.D

    2017-01-01

    This study aims to evaluate the usefulness of a commercial textbook entitle “Skillful: Reading & Writing, Student’s Book 1”, written by David Bohlke with Dorothy E. Zemach as a series consultant, published by Macmillan publisher. The study also explores the appropriateness for considering to teaching university EFL students. The result of this study assists English teachers in choosing textbooks which will be most appropriate to the learners at various level to develop their reading and writi...

  20. Meet the Authors of "Social Context View of Sociology" by Marty Zusman, David Knox and Tracie Gardner:

    Directory of Open Access Journals (Sweden)

    Marty E. Zusman

    2008-01-01

    Full Text Available The Social Context View of Sociology by Marty E. Zusman, David Knox, and Tracie Gardner (2009 is an introductory sociology textbook published by Carolina University Press (ISBN 978-1-59460-572-7. The purpose of writing The Social Context View of Sociology was to provide a unique perspective of the social world. More importantly, to avoid what we consider the sometimes confusing introduction of the discipline (by standard textbooks into diverse frameworks, we presented a basic typology.

  1. David Triggle: Research collaborations and scientific exchanges with the China Pharmaceutical University, Nanjing, China.

    Science.gov (United States)

    Dai, De-Zai

    2015-11-15

    Over the period 1995-2012, David Triggle was a frequent visitor to the China Pharmaceutical University in Nanjing, China making many important contributions that enhanced the activities of the Research Division of Pharmacology at the University. In addition to providing collegial advice and facilitating interactions with the international pharmacological community, Professor Triggle's international reputation as a thought leader in the field of ion channel research and drug discovery provided important insights into the potential pathophysiological and therapeutic effects of targeting ion channels. This included the L-type calcium channel and the outward delayed rectified potassium currents of rapid (IKr) and slow (IKs) components in the myocardium. The Nanjing research team had been particularly interested in ion channel dysfunction in the context of cardiac arrhythmias, remodeling and drug discovery. With Professor Triggle's assistance, the relationship between an increase in ICa.L and other biological events including an enhancement of IKr and IKr currents, NADPH oxidase and endothelin receptor activation, down regulation of calcium modulating protein FKBP12.6, sarco/endoplasmic reticulum Ca(2+)ATPse (SERCA2A) and calsequens 2 (CASQ2), calcium leak at the diastole and endoplasmic reticulum stress, were evaluated and are discussed. Additionally, the organization of several international symposia was greatly enhanced by input from Professor Triggle as were the published research manuscripts in international pharmacology journals. During his association with the China Pharmaceutical University, Professor Triggle aided in enhancing the scientific standing of the Pharmacology department and was a highly effective ambassador for international research cooperation. Copyright © 2015. Published by Elsevier Inc.

  2. Evidence-based medicine has been hijacked: a report to David Sackett.

    Science.gov (United States)

    Ioannidis, John P A

    2016-05-01

    This is a confession building on a conversation with David Sackett in 2004 when I shared with him some personal adventures in evidence-based medicine (EBM), the movement that he had spearheaded. The narrative is expanded with what ensued in the subsequent 12 years. EBM has become far more recognized and adopted in many places, but not everywhere, for example, it never acquired much influence in the USA. As EBM became more influential, it was also hijacked to serve agendas different from what it originally aimed for. Influential randomized trials are largely done by and for the benefit of the industry. Meta-analyses and guidelines have become a factory, mostly also serving vested interests. National and federal research funds are funneled almost exclusively to research with little relevance to health outcomes. We have supported the growth of principal investigators who excel primarily as managers absorbing more money. Diagnosis and prognosis research and efforts to individualize treatment have fueled recurrent spurious promises. Risk factor epidemiology has excelled in salami-sliced data-dredged articles with gift authorship and has become adept to dictating policy from spurious evidence. Under market pressure, clinical medicine has been transformed to finance-based medicine. In many places, medicine and health care are wasting societal resources and becoming a threat to human well-being. Science denialism and quacks are also flourishing and leading more people astray in their life choices, including health. EBM still remains an unmet goal, worthy to be attained. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. MATERNAL AND NEONATAL CARE IN DAVID CAPISTRANO FILHO BIRTH CENTER, RIO DE JANEIRO, BRAZIL

    Directory of Open Access Journals (Sweden)

    Adriana Lenho de Figueiredo Pereira

    2012-04-01

    Full Text Available Objetivo: Analisar os dados maternos e neonatais dos atendimentos realizados por enfermeiras obstétricas em casa de parto. Método: Pesquisa transversal e retrospectiva, que utilizou os documentos oficiais de produtividade e perfil anual do atendimento da Casa de Parto David Capistrano Filho, período março de 2004 a dezembro de 2009. Os dados receberam tratamento estatístico descritivo e foram comparados aos resultados de pesquisas nacionais e internacionais. Resultados: Foram atendidos 1477 partos normais e 1475 nascidos vivos. A episiotomia foi realizada em 3,9% das parturientes e o trauma perineal grave ocorreu em 0,27% dos partos. Os casos de asfixia neonatal representaram 0,3% dos nascidos vivos, os demais nasceram em boas condições de vitalidade. As transferências maternas (12,3% para o hospital foram causadas pela bolsa amniótica rota (33%, mecônio no líquido amniótico (22,5 e distócias (19,2%. O desconforto respiratório (30,6%, hipoatividade/sucção débil (17,3%, baixo peso/prematuridade (16,3% e infecção (15,3% causaram as transferências neonatais (6,6%. Conclusão: As parturientes atendidas tiveram a presença do acompanhante, o períneo foi preservado no parto e seus filhos nasceram em boas condições de vitalidade. Os indicadores assistenciais foram semelhantes aos descritos em pesquisas nacionais e internacionais sobre os Centros de Parto. As transferências neonatais foram mais elevadas em comparação aos Centros de Parto brasileiros. Descritores:  Assistência de enfermagem, Centros independentes de assistência à gravidez e ao parto, Parto humanizado

  4. Aortic valve-sparing in 37 patients with Marfan syndrome: midterm results with David operation.

    Science.gov (United States)

    Forteza, Alberto; De Diego, Javier; Centeno, Jorge; López, Maria Jesus; Pérez, Enrique; Martín, Carlos; Sánchez, Violeta; Rufilanchas, Juan J; Cortina, Jose

    2010-01-01

    We reviewed our experience with aortic valve-sparing operations in Marfan syndrome during last 5 years. Between March 2004 and June 2009, 94 patients with aortic root aneurysms underwent valve-sparing operations. Of these, 37 (68% male) were diagnosed with Marfan syndrome, according to the Ghent diagnostic criteria. Mean age was 30 +/- 10 years (range, 11 to 59 years). Moderate/severe aortic regurgitation was present in 13%, and the mean diameter of the Valsalva sinuses was 50 +/- 4 mm (range, 42 to 62 mm). The David V modification was performed in the last 28 patients. Additional procedures were mitral valve repair in 6, tricuspid valve repair in 3, closure of septal atrial defect in 2, and closure of a patent foramen ovale in 13. Mean follow-up was 27 +/- 16 months (range, 1 to 61 months). There were no in-hospital deaths and no major adverse outcomes. One patient required implantation of a mechanical prosthesis during the same procedure because of moderate aortic regurgitation. One late death occurred. No patients required reoperation. In the last follow-up, 23 patients did not have aortic regurgitation, 12 had grade I, and 1 had grade II. No thromboembolic complications have been documented, and 97% of the patients are free from anticoagulation. Short-term and midterm results with the reimplantation technique for aortic root aneurysms in Marfan patients are excellent. If long-term results are similar, this technique could be the treatment of choice for these patients. 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  5. El último lector de David Toscana o la lectura como revelación

    Directory of Open Access Journals (Sweden)

    Ada Aurora Sánchez Peña

    2011-01-01

    Full Text Available La ectura, vista como proceso o como producto, no es sino un entrecruce de subjetividades, un ir hacia el otro y lo otro. Como desplazamiento, encuentro y revelación, la lectura es la única vía a través de la cual el texto emerge más allá de su materialidad. Ya lo dijo Wolfgang Iser: “un texto sólo despierta a la vida cuando es leído” (Iser, 1993: 99-100. Desde la metaliteratura, los dobleces y complejidades del acto de leer han sido motivo de reflexión y exploración, aunque probablemente menos que los vinculados particularmente a los problemas de la escritura literaria. Desde la posición de autorreferencialidad, el lenguaje artístico observa el universo extraordinario que se despliega en la producción y recepción del mensaje literario. En este texto se busca examinar la lectura como eje temático de la novela El último lector (Anagrama, 2004a,1 del escritor regiomontano David Toscana (1961. Asomarse a la propuesta metaliteraria de uno de los exponentes más distinguidos de la narrativa mexicana actual permite un acercamiento a diversas cuestiones asociadas al acto de leer, por ejemplo, el placer estético, los tipos de lectores, la novela como género literario, el paso de la realidad a la ficción, la impostación, así como la relación entre vida y literatura, por señalar algunos. Sobre todo, se está al alcance de una visión de mundo fincada en cierta medida en la asunción de la lectura como descubrimiento y revelación.

  6. Bronze flagon from Pontes with an inscription from the 29th Psalm of David

    Directory of Open Access Journals (Sweden)

    Popović Ivana

    2015-01-01

    Full Text Available During the campaign which took place in 1983 at the site of Pontes - Trajan’s Bridge near Kostol, in the layer between a house from the second half of the 9th century and a house from the 11th century, a treasury consisting of medieval iron tools placed around, or inserted into, a bronze flagon was discovered in a shallow pit. The whole find was named Treasury B. At first, the flagon itself was dated into the period between the 6th and the 8th centuries, however, we have recently dated it into the 6th-7th century. The inscription on the neck of the vessel is a paraphrase of the 3rd verse from the 29th Psalm of David. This is proof that the flagon was a liturgical vessel. In this text we are trying to show that this flagon was analogous to the specimen from the treasury from Vrap in Albania, whose deposition during the third part of the 7th century is connected with the activity of Bulgarian Khan Kuber. The Byzantine vessel was a part of treasure plundered from the Avars, and the production of this flagon, just as of that one from Pontes, can be dated into the period between the 6th century and the first half or the middle of the 7th century. [Projekat Ministarstva nauke Republike Srbije, br. 177007: Romanisation, urbanisation and transformation of urban centres of civil, military and residential character in Roman provinces in the territory of Serbia

  7. Tampere Teattrerikesä algas veidi teispoolselt / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2005-01-01

    Soomes alanud teatrifestivalist Tampere teatrisuvi. Pikemalt A. Raivio "Viimasest karavanist" Q-teatteri esituses, M. Ivashkeviciuse " Poisikesest" Korshunovase Teatri ja Vilniuse Linnateatri koostöös ning sakslaste norton.commander.productions lavastusest "Solaris"

  8. Omadraama pärjas eestlasi / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2006-01-01

    Balti teatrifestivalil "OmaDraama 2006" nähtud etendustest said viis auhinda eestlased - Mart Kivastik näidendi "Põrgu Wärk" eest, Hendrik Toompere lavastuse eest, Harriet Toompere naisosatäitmise eest, Jan Uuspõld Wiiralti kehastamise eest ning Margus Prangel Tuglase osa eest; Merle Karusoo sai auhinna järjepidevuse eest sotsiaalselt aktuaalsete probleemide tõstatamisel. Ülejäänud kaks auhinda said läti trupi lavastus "P:S. Pöialpoiss" ning leedu luuletaja ja näitleja Birute Mar Salomeja Nerise kuju eest lavastuses "Poetess"

  9. Nüganeni "Laulatus" festivalil DRAAMA 2005 / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2005-01-01

    Selle aasta Draama festivali üheks väliskülaliseks on Poola Toruni Wilam Horzyca teater lavastusega "Laulatus". W. Gombrowiczi näidendi lavastajaks on Tallinna Linnateatri peanäitejuht E. Nüganen

  10. Mida teeks tulevane kultuuriminister 500 miljoni krooniga? / interv. Andres Keil

    Index Scriptorium Estoniae

    2007-01-01

    Suuremate erakondade kultuurispetsialistid (kultuuriministrikandidaadid) Urmas Paet, Andres Herkel, Peeter Jalakas, Indrek Saar, Jaak Allik, samuti kultuuriminister Raivo Palmaru vastavad küsimustele, mis on suurimad ohud eesti keele ja rahvuskultuuri säilimisele, milline on kultuuriministeeriumi ja -ministri portfelli staatus praeguses valitsuses, kas kultuuri rahastamine riigieelarvest on piisav, mille poolest erineb nende erakonna nägemus kultuuripoliitikast teiste erakondade omast, kuhu nad suunaksid 50, 500 miljonit, kui see oleks nende käsutuses

  11. Bulgaaria maanteenomaadid Tallinna tänavatel. Teater / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2008-01-01

    Märtsis kaubaveoautol toimuvatest etendustest "Cargo Sofia-Tallinn". Esitavad bulgaaria treilerijuhid Ventzislav Borissov ja Nedjalko Nedjalkov. Teose autorid on Stefan Kaegi ja Jörg Karrenbauer. Lavastus on sissejuhatuseks suvisele teatrifestivalile Baltoscandal

  12. "Lavakad" laval - kaheksa kuud enne diplomit / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Eesti Muusika ja Teatriakadeemia Lavakunstikooli 23. lennu lavastustest : kaksiklavastus "Pink" VAT Teatris, Mart Kase "Perekond" Eesti Nuku- ja Noorsooteatris ja William Shakespeare'i "Eksituste komöödia" Stephen Harperi ja Elmo Nüganeni lavastuses Hobuveskis

  13. Estonia näitas uut logo / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2004-01-01

    Ooperiteatri uue logo autor on Kristjan Kirsfeldt. Liis Kolle lavastab G. Rossini ooperi "Sinjoor Bruschino ehk Poeg juhuse tahtel", kunstnikud Liina Keevallik ja Reili Evart. 2. juunil Rahvusooperis etendunud rahvusooperi näiteringi "Welcome to Estonia" Neeme Kuninga kirjutatud ja lavastatud muusikalist "Minu veetlev Eedi".

  14. Eks eklektikat Piiteris jätku ... / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2004-01-01

    Peterburi festivalist "Uus draama" (Novaja drama), pikemalt peatutakse Aleksei Kazantsevi ja Mihhail Rozhini juhitava Moskva dramaturgia ja rezhissuuri keskuse esitatud H. Kraussleri tükil "Peatus. Kummitused" I. Selini lavastuses

  15. Lectures of David Olive on gauge theories and Lie algebras with some applications to spontaneous symmetry breaking and integrable dynamical systems

    CERN Document Server

    Turok, Neil

    2018-01-01

    Professor David Olive was a renowned British theoretical physicist who made seminal contributions to superstrings, quantum gauge theories and mathematical physics. He was awarded the Dirac Medal by the International Centre for Theoretical Physics in Trieste in 1997, with his long-standing collaborator Peter Goddard. David Olive was a Fellow of the Royal Society and a Founding Fellow of the Learned Society of Wales. David Olive was known for his visionary conjectures, including electromagnetic duality in spontaneously broken gauge theories, as well as his exceptionally clear and insightful style of exposition. These lectures, delivered by David Olive in 1982 at the University of Virginia, provide a pedagogical, self-contained introduction to gauge theory, Lie algebras, electromagnetic duality and integrable models. Despite enormous subsequent developments, they still provide a valuable entry point to some of the deepest topics in quantum gauge theory.

  16. Review of David Abrahamson and Marcia R. Prior-Miller (eds, The Routledge Handbook of Magazine Research: The Future of the Magazine Form (2015

    Directory of Open Access Journals (Sweden)

    Maaike Koffeman

    2016-07-01

    Full Text Available David Abrahamson and Marcia R. Prior-Miller (eds, The Routledge Handbook of Magazine Research: The Future of the Magazine Form (New York: Routledge, 2015. 650 pp. ISBN 978-1138854161.

  17. Consumption of Sugars, Sugary Foods and Sugary Beverages in Relation to Adiposity-Related Cancer Risk in the Framingham Offspring Cohort (1991-2013).

    Science.gov (United States)

    Makarem, Nour; Bandera, Elisa V; Lin, Yong; Jacques, Paul; Hayes, Richard B; Parekh, Niyati

    2018-04-19

    Higher sugar consumption may increase cancer risk by promoting insulin-glucose dysregulation, oxidative stress, hormonal imbalances, and excess adiposity. This prospective study investigates the association between dietary sugars(fructose and sucrose) and sugary foods and beverages in relation to combined and site-specific (breast, prostate, colorectal) adiposity-associated cancers. The analytic sample consisted of 3,184 adults, aged 26-84y, from the Framingham Offspring cohort. Diet data was first collected between 1991-1995 using a food frequency questionnaire. Intakes of fructose, sucrose, sugary foods and sugary beverages (fruit juice and sugar-sweetened beverages) were derived. Participants were followed up until 2013 to ascertain cancer incidence; 565 doctor-diagnosed adiposity-related cancers, including 124 breast, 157 prostate and 68 colorectal cancers occurred. Multivariable-adjusted Cox proportional hazards models were used to evaluate associations. Tests for interaction with BMI and waist circumference were conducted. No associations were observed between fructose, sucrose, sugary food consumption and combined incidence of adiposity-related cancers or the examined site-specific cancers. While total consumption of sugary beverages was not associated with site-specific cancer risk, higher intakes of fruit juice were associated with 58% increased prostate cancer risk(HR:1.58;95%CI:1.04-2.41) in multivariable-adjusted models. In exploratory stratified analyses, higher sugary beverage intakes increased overall adiposity-related cancer risk by 59% in participants with excessive central adiposity(HR:1.59;95%CI:1.01-2.50)(p-trend=0.057). In this cohort of American adults, higher sugary beverage consumption was associated with increased cancer risk among participants with central adiposity. These analyses suggest that avoiding sugary beverages represents a simple dietary modification that may be used as an effective cancer control strategy. Copyright ©2018

  18. Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study.

    Science.gov (United States)

    van Himbergen, Thomas M; Beiser, Alexa S; Ai, Masumi; Seshadri, Sudha; Otokozawa, Seiko; Au, Rhoda; Thongtang, Nuntakorn; Wolf, Philip A; Schaefer, Ernst J

    2012-05-01

    To investigate the contribution of biomarkers of glucose homeostasis (adiponectin, glucose, glycated albumin, and insulin levels) and inflammation (high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A(2) levels) to the risk of developing Alzheimer disease (AD) and all-cause dementia. Prospective cohort study. Dementia-free Framingham Heart Study participants had sera measured for these biomarkers at the 19th biennial examination (1985-1988) and were followed up prospectively for the development of AD and all-cause dementia. Eight hundred forty (541 women, median age of 76 years) subjects participated in the study. We used sex-pooled and sex-specific multivariable Cox proportional hazards models adjusted for age, education, body mass index, recent change in weight, APOE ε4 allele status, and plasma docosahexaenoic acid levels to determine association of these biomarkers with the development of all-cause dementia and AD. Over a mean follow-up period of 13 years, 159 persons developed dementia (including 125 with AD). After adjustment for other risk factors, only adiponectin in women was associated with an increased risk of all-cause dementia (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.00-1.66; P=.054) and AD (HR, 1.33; 95% CI, 1.00-1.76; P=.050) per 1-SD increase in adiponectin level. Women with baseline adiponectin values more than the median had a higher risk of all-cause dementia (HR, 1.63; 95% CI, 1.03-2.56; P=.04) and AD (HR, 1.87; 95% CI, 1.13-3.10; P=.01) as compared with those with values less than the median. In women, increased plasma adiponectin levels are an independent risk factor for the development of both all-cause dementia and AD.

  19. Lower Lean Mass Measured by Dual-Energy X-ray Absorptiometry (DXA) is Not Associated with Increased Risk of Hip Fracture in Women: The Framingham Osteoporosis Study.

    Science.gov (United States)

    McLean, Robert R; Kiel, Douglas P; Berry, Sarah D; Broe, Kerry E; Zhang, Xiaochun; Cupples, L Adrienne; Hannan, Marian T

    2018-01-05

    Although muscle mass influences strength in older adults, it is unclear whether low lean mass measured by dual-energy X-ray absorptiometry (DXA) is an independent risk factor for hip fracture. Our objective was to determine the association between DXA lean mass and incident hip fracture risk among 1978 women aged 50 years and older participating in the Framingham Study Original and Offspring cohorts. Leg and total body lean mass (kg) were assessed from whole-body DXA scans collected in 1992-2001. Hip fracture follow-up extended from DXA assessment to the occurrence of fracture, death, drop-out, or end of follow-up in 2007. Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) estimating the relative risk of hip fracture associated with a 1-kg increase in baseline lean mass. Mean age was 66 years (range 50-93). Over a median of 8 years of follow-up, 99 hip fractures occurred. In models adjusted for age, height, study cohort, and percent total body fat, neither leg (HR 1.11; 95% CI 0.94, 1.31) nor total body (HR 1.06; 95% CI 0.99, 1.13) lean mass were associated with hip fracture. After further adjustment for femoral neck bone mineral density, leg lean mass results were similar (HR 1.10; 95% CI 0.93, 1.30). In contrast, 1 kg greater total body lean mass was associated with 9% higher hip fracture risk (HR 1.09; 95% CI 1.02, 1.18). Our findings suggest that in women, lower lean mass measured by DXA is not associated with increased risk of hip fracture.

  20. Physical activity, the Framingham risk score and risk of coronary heart disease in men and women of the EPIC-Norfolk study.

    Science.gov (United States)

    Arsenault, Benoit J; Rana, Jamal S; Lemieux, Isabelle; Després, Jean-Pierre; Wareham, Nicholas J; Kastelein, John J P; Boekholdt, S Matthijs; Khaw, Kay-Tee

    2010-03-01

    Test the hypothesis that considering leisure-time and work-related physical activity habits in addition to the Framingham risk score (FRS) would result into better classification of coronary heart disease (CHD) risk than FRS alone. Prospective, population-based study of 9564 men and 12165 women aged 45-79 years followed for an average of 11.4 years. A modified FRS which takes into account physical activity (evaluated using a validated lifestyle questionnaire taking into account leisure-time and work-related physical activity) was computed. During follow-up, 2191 CHD events occurred. Among 3369 men who were classified as intermediate risk (event rate of 12.4%) according to the FRS, 413 were reclassified into the low-risk category and 279 were reclassified into the high-risk category after modification of the FRS. After reclassification of these men, CHD event rate was of 5.3% and 18.6%, respectively for men classified at low and high CHD risk. Among 4766 women initially classified as intermediate risk (event rate of 8.4%), 1282 were reclassified into the low-risk category whereas 1071 women were reclassified into the high-risk category. After reclassification of these women, CHD event rate was of 6.8% and 12.2%, respectively for women classified at low and high CHD risk. Results of the present study suggest that asking simple questions about leisure-time and work-related physical activity which can be rapidly obtained by any physician at no cost could be helpful in the estimation of patients' CHD risk.

  1. Serum urate gene associations with incident gout, measured in the Framingham Heart Study, are modified by renal disease and not by body mass index.

    Science.gov (United States)

    Reynolds, Richard J; Vazquez, Ana I; Srinivasasainagendra, Vinodh; Klimentidis, Yann C; Bridges, S Louis; Allison, David B; Singh, Jasvinder A

    2016-02-01

    We hypothesized that serum urate-associated SNPs, individually or collectively, interact with BMI and renal disease to contribute to risk of incident gout. We measured the incidence of gout and associated comorbidities using the original and offspring cohorts of the Framingham Heart Study. We used direct and imputed genotypes for eight validated serum urate loci. We fit binomial regression models of gout incidence as a function of the covariates, age, type 2 diabetes, sex, and all main and interaction effects of the eight serum urate SNPs with BMI and renal disease. Models were also fit with a genetic risk score for serum urate levels which corresponds to the sum of risk alleles at the eight SNPs. Model covariates, age (P = 5.95E-06), sex (P = 2.46E-39), diabetes (P = 2.34E-07), BMI (P = 1.14E-11) and the SNPs, rs1967017 (P = 9.54E-03), rs13129697 (P = 4.34E-07), rs2199936 (P = 7.28E-03) and rs675209 (P = 4.84E-02) were all associated with incident gout. No BMI by SNP or BMI by serum urate genetic risk score interactions were statistically significant, but renal disease by rs1106766 was statistically significant (P = 6.12E-03). We demonstrated that minor alleles of rs1106766 (intergenic, INHBC) were negatively associated with the risk of incident gout in subjects without renal disease, but not for individuals with renal disease. These analyses demonstrate that a significant component of the risk of gout may involve complex interplay between genes and environment.

  2. David Grant Medical Center energy use baseline and integrated resource assessment

    Energy Technology Data Exchange (ETDEWEB)

    Richman, E.E.; Hoshide, R.K.; Dittmer, A.L.

    1993-04-01

    The US Air Mobility Command (AMC) has tasked Pacific Northwest Laboratory (PNL) with supporting the US Department of Energy (DOE) Federal Energy Management Program`s (FEMP) mission to identify, evaluate, and assist in acquiring all cost-effective energy resource opportunities (EROs) at the David Grant Medical Center (DGMC). This report describes the methodology used to identify and evaluate the EROs at DGMC, provides a life-cycle cost (LCC) analysis for each ERO, and prioritizes any life-cycle cost-effective EROs based on their net present value (NPV), value index (VI), and savings to investment ratio (SIR or ROI). Analysis results are presented for 17 EROs that involve energy use in the areas of lighting, fan and pump motors, boiler operation, infiltration, electric load peak reduction and cogeneration, electric rate structures, and natural gas supply. Typical current energy consumption is approximately 22,900 MWh of electricity (78,300 MBtu), 87,600 kcf of natural gas (90,300 MBtu), and 8,300 gal of fuel oil (1,200 MBtu). A summary of the savings potential by energy-use category of all independent cost-effective EROs is shown in a table. This table includes the first cost, yearly energy consumption savings, and NPV for each energy-use category. The net dollar savings and NPV values as derived by the life-cycle cost analysis are based on the 1992 federal discount rate of 4.6%. The implementation of all EROs could result in a yearly electricity savings of more than 6,000 MWh or 26% of current yearly electricity consumption. More than 15 MW of billable load (total billed by the utility for a 12-month period) or more than 34% of current billed demand could also be saved. Corresponding natural gas savings would be 1,050 kcf (just over 1% of current consumption). Total yearly net energy cost savings for all options would be greater than $343,340. This value does not include any operations and maintenance (O&M) savings.

  3. David Grant Medical Center energy use baseline and integrated resource assessment

    Energy Technology Data Exchange (ETDEWEB)

    Richman, E.E.; Hoshide, R.K.; Dittmer, A.L.

    1993-04-01

    The US Air Mobility Command (AMC) has tasked Pacific Northwest Laboratory (PNL) with supporting the US Department of Energy (DOE) Federal Energy Management Program's (FEMP) mission to identify, evaluate, and assist in acquiring all cost-effective energy resource opportunities (EROs) at the David Grant Medical Center (DGMC). This report describes the methodology used to identify and evaluate the EROs at DGMC, provides a life-cycle cost (LCC) analysis for each ERO, and prioritizes any life-cycle cost-effective EROs based on their net present value (NPV), value index (VI), and savings to investment ratio (SIR or ROI). Analysis results are presented for 17 EROs that involve energy use in the areas of lighting, fan and pump motors, boiler operation, infiltration, electric load peak reduction and cogeneration, electric rate structures, and natural gas supply. Typical current energy consumption is approximately 22,900 MWh of electricity (78,300 MBtu), 87,600 kcf of natural gas (90,300 MBtu), and 8,300 gal of fuel oil (1,200 MBtu). A summary of the savings potential by energy-use category of all independent cost-effective EROs is shown in a table. This table includes the first cost, yearly energy consumption savings, and NPV for each energy-use category. The net dollar savings and NPV values as derived by the life-cycle cost analysis are based on the 1992 federal discount rate of 4.6%. The implementation of all EROs could result in a yearly electricity savings of more than 6,000 MWh or 26% of current yearly electricity consumption. More than 15 MW of billable load (total billed by the utility for a 12-month period) or more than 34% of current billed demand could also be saved. Corresponding natural gas savings would be 1,050 kcf (just over 1% of current consumption). Total yearly net energy cost savings for all options would be greater than $343,340. This value does not include any operations and maintenance (O M) savings.

  4. "implicate Order" and the Good Life: Applying David Bohm's Ontology in Human World

    Science.gov (United States)

    Ravn, Ib.

    In an attempt to formulate a coherent view of quantum reality, the theoretical physicist David Bohm has proposed a new concept of order to supplement the mechanistic Cartesian order of traditional physics. The "implicate" order is a subtler and deeper order that emphasizes "unbroken wholeness in flowing movement," in contrast to the coarser and more superficial, "explicate" Cartesian order of distinct phenomena. This dissertation attempts to develop a meaning for the idea of implicate order in the world of human experience. First is offered an account of some evolutionary episodes in terms of implicate and explicate order which draws on compatible work in cosmology, embryogenesis, visual perception, brain memory, decision making and phenomenology. Two important characteristics of the implicate order are then identified: in an implicate order, the whole is enfolded (or represented) in its parts; and all parts render different perspectives of the whole. Using arguments from decision making, the study of "flow" in human consciousness, and a model of skill acquisition, it is suggested that these characteristics manifest themselves in the human world as the "unity experience" and the "diversity experience," respectively. The former is the experience that a given part of one's life reveals a larger wholeness or unity; the subject-object distinction is transcended and one becomes absorbed in the flow of whatever activity is pursued. The latter is a deep appreciation of the diversity of ways in which people may seek the unity experience. These experiences are proposed as general values: social and psychological conditions ought to be such that these experiences are enhanced in all people. A two-by-two matrix of the two experiences demonstrates the danger of pursuing one to the exclusion of the other. The experience of unity without diversity turns into absolutism, the insistence that one's chosen activities or beliefs are the only right ones. The experience of diversity

  5. Risk Factors for Late Aortic Valve Dysfunction After the David V Valve-Sparing Root Replacement.

    Science.gov (United States)

    Esaki, Jiro; Leshnower, Bradley G; Binongo, Jose N; Lasanajak, Yi; McPherson, LaRonica; Guyton, Robert A; Chen, Edward P

    2017-11-01

    Valve-sparing root replacement (VSRR) is an established therapy for aortic root pathology. However, late aortic valve dysfunction requiring reoperation remains a primary concern of this procedure. This study examines risk factors for late aortic insufficiency (AI) and aortic stenosis (AS) after David V VSRR. A retrospective review from 2005 to 2015 at a US academic center identified 282 patients who underwent VSRR. Cox proportional hazards regression analysis was used to identify risk factors for late AI and AS after VSRR. The mean age was 46.4 years. Sixty-four patients (22.7%) had bicuspid valves, and 41 patients (14.5%) had Marfan syndrome. The incidence of reoperations was 27 (9.6%), and 42 cases (14.9%) presented with acute type A dissection. Operative mortality was 8 (2.8%). Seven-year survival was 90.9%. Seven-year cumulative incidence of reoperation, greater than 2+ AI and greater than moderate AS were 3.1%, 2.2%, and 0.8%, respectively. Multivariable analysis showed aortic root size 55 mm or larger (hazard ratio 3.44, 95% confidence interval: 1.27 to 9.29, p = 0.01) to be a risk factor for late AI whereas bicuspid valve (hazard ratio 16.07, 95% confidence interval: 3.12 to 82.68, p = 0.001) and cusp repair were found to be risk factors (hazard ratio 5.91, 95% confidence interval: 1.17 to 29.86, p = 0.03) for late AS. Valve-sparing root replacement can be performed with low operative risk and good overall long-term survival even in complex clinical settings. Durable valve function can be expected; however, aortic root size 55 cm or more, bicuspid valve anatomy, and cusp repair represent independent risk factors for late aortic valve dysfunction after these procedures. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  6. The Discovery of Anti-Matter The Autobiography of Carl David Anderson, the Youngest Man to Win the Nobel Prize

    CERN Document Server

    1999-01-01

    In 1936, at age 31, Carl David Anderson became the second youngest Nobel laureate for his discovery of antimatter when he observed positrons in a cloud chamber.He is responsible for developing rocket power weapons that were used in World War II.He was born in New York City in 1905 and was educated in Los Angeles. He served for many years as a physics professor at California Institute of Technology. Prior to Oppenheimer, Anderson was offered the job of heading the Los Alamos atomic bomb program but could not assume the role because of family obligations.He was a pioneer in studying cosmic rays

  7. The Contrasting Soundscapes of Hull and London in David Bowie’s Ziggy Stardust and the Spiders from Mars

    OpenAIRE

    Atkinson, Peter James

    2017-01-01

    In this article I apply the concept of the urban soundscape as developed by Long and Collins (2012) in an analysis of the impact musicians from Hull had on the evolution of David Bowie’s seminal 1972 work The Rise and Fall of Ziggy Stardust and the Spiders from Mars. I argue that the performance of Ziggy Stardust, both on record and on stage, is doubly coded in relation to place and space. The 'concept' of The Rise and Fall of Ziggy Stardust as a musical, a fictional story with songs performe...

  8. The Ideas as Copies of our Impressions or Metaphors of the Reality: Dialogue Among David Hume, Locke and Nietzsche

    OpenAIRE

    Edwin Adolfo Garavito Muñoz

    2012-01-01

    Este artículo trata las ideas de David Hume sobre la concepción de un diálogo con la noción de lenguaje de Locke, a fin de hacer un contraste con la propuesta de Nietzsche sobre el lenguaje en su texto "Sobre ver - dad y mentira en sentido extramoral". Esta es una manera riesgosa para enfocar la reflexión, pero que va a encontrar algunas ideas adicionales sobre el mundo del lenguaje y el mundo real.

  9. The Ideas as Copies of our Impressions or Metaphors of the Reality: Dialogue Among David Hume, Locke and Nietzsche

    Directory of Open Access Journals (Sweden)

    Edwin Adolfo Garavito Muñoz

    2012-01-01

    Full Text Available Este artículo trata las ideas de David Hume sobre la concepción de un diálogo con la noción de lenguaje de Locke, a fin de hacer un contraste con la propuesta de Nietzsche sobre el lenguaje en su texto "Sobre ver - dad y mentira en sentido extramoral". Esta es una manera riesgosa para enfocar la reflexión, pero que va a encontrar algunas ideas adicionales sobre el mundo del lenguaje y el mundo real.

  10. Seyed Mohammad Hossein Tabatabai and David Hume in the philosophical basis for determining the values

    Directory of Open Access Journals (Sweden)

    Mahdi Dehbashi

    2013-08-01

    Full Text Available allameh sayyid muhammad husain tabatabaei and David Hume, in regard to influential philosophical thought's, are very important, one in the Muslim world and The other in the West world. Allama has mentioned his thoughts on ethics, in his two books, the principles of philosophy and Method of realism and Al-Mizan interpretation (Quranic exegesis. In The principles of philosophy and Method of realism, his main discussions are actions that export from agent and the relationship between agent and action. In the sixth chapter of the book, Allama generally analyzes mental aspects, and in particular, examines the psychophilosophical analysis and epistemology of the moral concepts. In terms of epistemology, ethics is one of the perceptions of mental aspects, and according to Allama, humans naturally can distinct right from wrong and take steps towards goodness and happiness. The second psychophilosophical aspect of ethics is related to good moral qualities and spiritual positive properties. As was stated before, humans, by nature, are equipped with the ability to recognize right and wrong; so it can be concluded in the issue of good moral qualities and spiritual positive properties, that virtues and vices are in the form of spiritual positive properties and that actualized in regard to need of Physical actions, and accordingly, humans are forced to take action. Allama in epistemological discussions and how human can obtain the knowledge has analyzed the agency of human and relationship between the agent and the action with the aim of demonstrating the role of reason and perceptions in all levels of human life as central and substantial. Hume at the beginning of the third book, a treatise on human nature, stated that "Morality is a subject that interests us above all others"; He spoke of the importance of this field of philosophy. You can even ponder and reflect on the previous parts of the book so that the introductions of a scheme of ethics are discussed

  11. Seyed Mohammad Hossein Tabatabai and David Hume in the philosophical basis for determining the values

    Directory of Open Access Journals (Sweden)

    Mohammad Javad Movahedi

    Full Text Available allameh sayyid muhammad husain tabatabaei and David Hume, in regard to influential philosophical thought's, are very important, one in the Muslim world and The other in the West world. Allama has mentioned his thoughts on ethics, in his two books, the principles of philosophy and Method of realism and Al-Mizan interpretation (Quranic exegesis. In The principles of philosophy and Method of realism, his main discussions are actions that export from agent and the relationship between agent and action. In the sixth chapter of the book, Allama generally analyzes mental aspects, and in particular, examines the psychophilosophical analysis and epistemology of the moral concepts. In terms of epistemology, ethics is one of the perceptions of mental aspects, and according to Allama, humans naturally can distinct right from wrong and take steps towards goodness and happiness. The second psychophilosophical aspect of ethics is related to good moral qualities and spiritual positive properties. As was stated before, humans, by nature, are equipped with the ability to recognize right and wrong; so it can be concluded in the issue of good moral qualities and spiritual positive properties, that virtues and vices are in the form of spiritual positive properties and that actualized in regard to need of Physical actions, and accordingly, humans are forced to take action. Allama in epistemological discussions and how human can obtain the knowledge has analyzed the agency of human and relationship between the agent and the action with the aim of demonstrating the role of reason and perceptions in all levels of human life as central and substantial.Hume at the beginning of the third book, a treatise on human nature, stated that "Morality is a subject that interests us above all others"; He spoke of the importance of this field of philosophy. You can even ponder and reflect on the previous parts of the book so that the introductions of a scheme of ethics are discussed

  12. Hear After: Matters of Life and Death in David Tudor’s Electronic Music

    Directory of Open Access Journals (Sweden)

    You Nakai

    2014-09-01

    Full Text Available In David Tudor’s electronic music, home-brew modular devices were carefully connected together to form complex feedback networks wherein all components—including the composer/performer himself—could only partially ‘influence’ one another. Once activated, the very instability of mismatched connections between the components triggered a cascade of signals and signal modulations, so that the work “composed itself,” and took “a life of its own.” Due to this self-producing, perpetuating nature of his works, Tudor insisted on what he called “the view from inside,” focusing more on the internal observation of his devices and sound than in materials external to the immanence of performance. When Tudor passed away in 1996, it became apparent that the sheer lack of resources outside the work—scores, instructions, recordings, texts—had made many of his music impossible to perform in his absence. The works that took a life of their own could not survive their composer’s death partially because of his utter reliance on them to do their work. By connecting often mismatched resources obtained from extended research on Tudor, this paper presents modular observations that seem to offer certain perspectives on the issue of life and death surrounding Tudor’s music. A comparison with developments in systems theory, most notably autopoiesis, outlines a mechanism for the endless life of sounds that compose themselves. Moving out of this theoretical reflection, a fieldwork report of an ongoing attempt to ‘revive’ some of Tudors works is offered. This report demonstrates the observer shifting from one ‘inside’ to another—from an electronic circuitry inside a particular device, to a network composed of several devices, and further into the activation of a composite instrument. Meandering away from the archives, the composer’s “view from inside” of his electronic devices is set side by side with recent insights of object

  13. Seyed Mohammad Hossein Tabatabai and David Hume in the philosophical basis for determining the values

    Directory of Open Access Journals (Sweden)

    Mohammad Javad Movahedi

    2013-09-01

    Full Text Available allameh sayyid muhammad husain tabatabaei and David Hume, in regard to influential philosophical thought's, are very important, one in the Muslim world and The other in the West world. Allama has mentioned his thoughts on ethics, in his two books, the principles of philosophy and Method of realism and Al-Mizan interpretation (Quranic exegesis. In The principles of philosophy and Method of realism, his main discussions are actions that export from agent and the relationship between agent and action. In the sixth chapter of the book, Allama generally analyzes mental aspects, and in particular, examines the psychophilosophical analysis and epistemology of the moral concepts. In terms of epistemology, ethics is one of the perceptions of mental aspects, and according to Allama, humans naturally can distinct right from wrong and take steps towards goodness and happiness. The second psychophilosophical aspect of ethics is related to good moral qualities and spiritual positive properties. As was stated before, humans, by nature, are equipped with the ability to recognize right and wrong; so it can be concluded in the issue of good moral qualities and spiritual positive properties, that virtues and vices are in the form of spiritual positive properties and that actualized in regard to need of Physical actions, and accordingly, humans are forced to take action. Allama in epistemological discussions and how human can obtain the knowledge has analyzed the agency of human and relationship between the agent and the action with the aim of demonstrating the role of reason and perceptions in all levels of human life as central and substantial. Hume at the beginning of the third book, a treatise on human nature, stated that "Morality is a subject that interests us above all others"; He spoke of the importance of this field of philosophy. You can even ponder and reflect on the previous parts of the book so that the introductions of a scheme of ethics are discussed

  14. The Prevalence of Cardiovascular Disease Risk Factors and the Framingham Risk Score in Patients Undergoing Percutaneous Intervention Over the Last 17 Years by Gender: Time-trend Analysis From the Mayo Clinic PCI Registry

    Directory of Open Access Journals (Sweden)

    Moo-Sik Lee

    2014-07-01

    Full Text Available Objectives: This study aims to investigate trends of cardiovascular disease (CVD risk factor profiles over 17 years in percutaneous coronary intervention (PCI patients at the Mayo Clinic. Methods: We performed a time-trend analysis within the Mayo Clinic PCI Registry from 1994 to 2010. Results were the incidence and prevalence of CVD risk factors as estimate by the Framingham risk score. Results: Between 1994 and 2010, 25 519 patients underwent a PCI. During the time assessed, the mean age at PCI became older, but the gender distribution did not change. A significant trend towards higher body mass index and more prevalent hypercholesterolemia, hypertension, and diabetes was found over time. The prevalence of current smokers remained unchanged. The prevalence of ever-smokers decreased among males, but increased among females. However, overall CVD risk according to the Framingham risk score (FRS and 10-year CVD risk significantly decreased. The use of most of medications elevated from 1994 to 2010, except for β-blockers and angiotensin converting enzyme inhibitors decreased after 2007 and 2006 in both baseline and discharge, respectively. Conclusions: Most of the major risk factors improved and the FRS and 10-year CVD risk declined in this population of PCI patients. However, obesity, history of hypercholesterolemia, hypertension, diabetes, and medication use increased substantially. Improvements to blood pressure and lipid profile management because of medication use may have influenced the positive trends.

  15. Thinking outside the Chinese Box: David Mitchell and Murakami Haruki’s subversion of stereotypes about Japan

    Directory of Open Access Journals (Sweden)

    Chikako Nihei

    2009-12-01

    Full Text Available Japan has often been portrayed by orientalist stereotypes, as famously framed by Edward Said, that were mainly constituted within Europe and North America. There are two distinct streams of orientalist discourse around Japan: traditional Orientalism and techno-Orientalism. Here the West speaks of the Other/the non-West rather than allowing it to speak for itself. In regards to the discourse of ‘Otherness’, another interesting phenomenon is Japan’s self-Orientalising: through the internalisation of the Western Orientalist discourse, Japan identifies itself and constructs its own subjectivity. In his literary works, the author David Mitchell attempts to subvert the conventional orientalist approach to describe Japan while concurrently maintaining his position as a British observer. He makes use of Western perspectives to cater to his Western readers’ preference for Japan’s traditional and cultural elements, and yet at the same time attempts to subvert stereotypes. Mitchell’s approach is reminiscent of Japanese author Murakami Haruki’s use of both ‘Japaneseness’ and ‘un-Japaneseness’ in his works. Mitchell also learnt the importance of the use of the subjective narrative voice from Murakami. In this article, I examine how David Mitchell, as a western author, attempts to go beyond orientalist stereotypes, and how his writing is influenced by Murakami Haruki.

  16. The moral status of the embryo: an attempt at an analysis with the aid of David Hume's ethics.

    Science.gov (United States)

    Engel, J B; Hönig, A; Segerer, S; Häusler, S F M; Dietl, J; Djakovic, A

    2010-12-01

    This article applies the moral sentimentalism founded by David Hume to the moral status of the embryo. It will attempt to explain the paradoxical fact that in Germany abortion is common and socially accepted while preimplantation genetic diagnosis is banned with the aid of an approach based on moral sentimentalism. David Hume established the thesis that the human being is guided by the emotions and not by reason when making moral decisions. Scientific innovations often create a feeling of anxiety. Consequently, the initial moral judgment about it is negative. Due to this habit, the innovation is often accepted after a phase of indifference. This phenomenon has been observed in the case of heart transplantation, as well as for IVF. Consequently, the apparent contradiction in the varying degrees of the embryo's worthiness of protection in the womb and in the Petri dish is due to the simple fact that these are different stages of habituation. Therefore, the ethics of Hume cannot stipulate the embryo's moral status for once and for all; however, they can paradoxically raise the ongoing current debate to a more rational level through the insight that the underlying moral concepts are not based on reason alone. Copyright © 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  17. Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study

    Science.gov (United States)

    Staerk, Laila; Wang, Biqi; Preis, Sarah R; Larson, Martin G; Lubitz, Steven A; Ellinor, Patrick T; McManus, David D; Ko, Darae; Weng, Lu-Chen; Lunetta, Kathryn L; Frost, Lars; Benjamin, Emelia J

    2018-01-01

    Abstract Objective To examine the association between risk factor burdens—categorized as optimal, borderline, or elevated—and the lifetime risk of atrial fibrillation. Design Community based cohort study. Setting Longitudinal data from the Framingham Heart Study. Participants Individuals free of atrial fibrillation at index ages 55, 65, and 75 years were assessed. Smoking, alcohol consumption, body mass index, blood pressure, diabetes, and history of heart failure or myocardial infarction were assessed as being optimal (that is, all risk factors were optimal), borderline (presence of borderline risk factors and absence of any elevated risk factor), or elevated (presence of at least one elevated risk factor) at index age. Main outcome measure Lifetime risk of atrial fibrillation at index age up to 95 years, accounting for the competing risk of death. Results At index age 55 years, the study sample comprised 5338 participants (2531 (47.4%) men). In this group, 247 (4.6%) had an optimal risk profile, 1415 (26.5%) had a borderline risk profile, and 3676 (68.9%) an elevated risk profile. The prevalence of elevated risk factors increased gradually when the index ages rose. For index age of 55 years, the lifetime risk of atrial fibrillation was 37.0% (95% confidence interval 34.3% to 39.6%). The lifetime risk of atrial fibrillation was 23.4% (12.8% to 34.5%) with an optimal risk profile, 33.4% (27.9% to 38.9%) with a borderline risk profile, and 38.4% (35.5% to 41.4%) with an elevated risk profile. Overall, participants with at least one elevated risk factor were associated with at least 37.8% lifetime risk of atrial fibrillation. The gradient in lifetime risk across risk factor burden was similar at index ages 65 and 75 years. Conclusions Regardless of index ages at 55, 65, or 75 years, an optimal risk factor profile was associated with a lifetime risk of atrial fibrillation of about one in five; this risk rose to more than one in three in individuals with at least

  18. Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham study.

    Science.gov (United States)

    Liu, Ching-Ti; Karasik, David; Zhou, Yanhua; Hsu, Yi-Hsiang; Genant, Harry K; Broe, Kerry E; Lang, Thomas F; Samelson, Elizabeth J; Demissie, Serkalem; Bouxsein, Mary L; Cupples, L Adrienne; Kiel, Douglas P

    2012-04-01

    Genetic factors likely contribute to the risk for vertebral fractures; however, there are few studies on the genetic contributions to vertebral fracture (VFrx), vertebral volumetric bone mineral density (vBMD), and geometry. Also, the heritability (h(2)) for VFrx and its genetic correlation with phenotypes contributing to VFrx risk have not been established. This study aims to estimate the h(2) of vertebral fracture, vBMD, and cross-sectional area (CSA) derived from quantitative computed tomography (QCT) scans and to estimate the extent to which they share common genetic association in adults of European ancestry from three generations of Framingham Heart Study (FHS) families. Members of the FHS families were assessed for VFrx by lateral radiographs or QCT lateral scout views at 13 vertebral levels (T(4) to L(4)) using Genant's semiquantitative (SQ) scale (grades 0 to 3). Vertebral fracture was defined as having at least 25% reduction in height of any vertebra. We also analyzed QCT scans at the L(3) level for integral (In.BMD) and trabecular (Tb.BMD) vBMD and CSA. Heritability estimates were calculated, and bivariate genetic correlation analysis was performed, adjusting for various covariates. For VFrx, we analyzed 4099 individuals (148 VFrx cases) including 2082 women and 2017 men from three generations. Estimates of crude and multivariable-adjusted h(2) were 0.43 to 0.69 (p < 1.1 × 10(-2)). A total of 3333 individuals including 1737 men and 1596 women from two generations had VFrx status and QCT-derived vBMD and CSA information. Estimates of crude and multivariable-adjusted h(2) for vBMD and CSA ranged from 0.27 to 0.51. In a bivariate analysis, there was a moderate genetic correlation between VFrx and multivariable-adjusted In.BMD (-0.22) and Tb.BMD (-0.29). Our study suggests vertebral fracture, vertebral vBMD, and CSA in adults of European ancestry are heritable, underscoring the importance of further work to identify the specific variants underlying

  19. Commentary on "The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)": Army STARRS: a Framingham-like study of psychological health risk factors in soldiers.

    Science.gov (United States)

    Ressler, Kerry J; Schoomaker, Eric B

    2014-01-01

    Although historically the Army suicide rate has been significantly lower than the civilian rate, in 2004, the suicide and accidental death rates began trending upward. By 2008, the Army suicide rate had risen above the national average (20.2 per 100,000). In 2009, 160 active duty Soldiers took their lives, making suicide the third leading cause of death among the Army population. If accidental death, frequently the result of high-risk behavior, is included, then more Soldiers died by their own actions than in combat in 2009. The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) was thus created in 2009 to begin to address these problems. The Army STARRS project is a large consortium of seven different studies to develop data-driven methods for mitigating or preventing suicide behaviors and improving the overall mental health and behavioral functioning of Army Soldiers during and after their Army service. The first research articles from the Army STARRS project were published in late 2013 and early 2014. This work has already begun to outline important facets of risk in the military, and it is helping to drive an empirically derived approach to improvements in understanding mental disorders and risk behavior and to improve prevention and support of mental health and resilience. The Framingham Heart Study, started in the 1940s, marked a watershed event in utilizing large cross-sectional and prospective longitudinal collaborative research to identify and understand risk factors for cardiovascular disease. The Army STARRS project, through its collaborative, prospective, and robust innovative design and implementation, may provide the beginning of a similar scientific cohort in mental disorders. The work of this project will help understand biological and psychological aspects of military service, including those leading to suicide. When coupled with timely feedback to Army leadership, it permits near real-time steps to diagnose, mitigate, and

  20. Cadrage, décadrage et recadrage dans Baa Baa Black Sheep : A Jungle Tale de David Malouf et Michael Berkeley Patrimonial Deconstruction and Reconstruction in David Malouf and Michael Berkeley’s Baa Baa Black Sheep : A Jungle Tale

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Héberlé

    2011-11-01

    Full Text Available This article discusses Michael Berkeley’s first opera, Baa Baa Black Sheep: A Jungle Tale. Premiered under the baton of Paul Daniel on July 3rd 1993 at the Cheltenham International Festival of Music, this opera is based on two texts by Rudyard Kipling: The Jungle Books (1894-1895 and “Baa, Baa, Black Sheep” from the short story collection Wee Willie Winkie and Other Stories, first published in 1888. The libretto was penned by the Australian poet, novelist, playwright and librettist, David Malouf. After a brief survey of some of the earliest transpositions of The Jungle Books, I analyse the way David Malouf deals with both texts. “Baa Baa Black Sheep” is used as the central element of his libretto, and episodes and characters from The Jungle Books are incorporated to draw parallelism between the main topics of the two texts. Both Malouf’s endeavour and Berkeley’s, through the music, aims at deconstructing the preposterous oldest transpositions of The Jungle Books and at focusing on the key elements of Kipling’s famous book, notably identity and hybridism, two important themes of colonial and postcolonial literature. The aim of David Malouf and Michael Berkeley is to address an adult audience and show that The Jungle Books are not only aimed at children as Disney’s or Baden Powell’s appropriations of the work could wrongly make us believe.Cet article porte sur Baa Baa Black Sheep: A Jungle Tale, le premier opéra de Michael Berkeley. Créé au Everyman Theatre de Cheltenham le 3 juillet 1993 sous la direction de Paul Daniel, cette œuvre est le fruit de la collaboration entre le compositeur britannique et l’écrivain australien David Malouf. Le livret de Malouf se fonde sur deux récits de Rudyard Kipling : la nouvelle autobiographique “Baa, Baa, Black Sheep” auquel l’opéra doit son nom et The Jungle Books. Après m’être intéressé aux premières transpositions musicales de The Jungle books, je montre comment

  1. Från outsiderfilmmakare till etablerad indieregissör : David Lynch, Jim Jarmusch och Steven Soderbergh

    OpenAIRE

    Simberg, Maximilian

    2014-01-01

    Det här arbetet behandlar kreativ frihet och konstnärligt oberoende i filmskapande, utgående från begreppet independent film och regissörerna David Lynch, Jim Jarmusch och Steven Soderbergh. Den centrala frågeställningen är hur det har varit möjligt för en filmkonstnär att uppnå konstnärligt oberoende och samtidigt ha en långlivad och framgångsrik karriär. Arbetets fokus ligger på de tre regissörernas genombrottsfilmer; Eraserhead, Stranger Than Paradise och sex, lies, and videotape, och förs...

  2. Assumidos: uma leitura em contos de Reinaldo Arenas, David Leavitt e João Silvério Trevisan

    OpenAIRE

    Trindade, Vivaldo Lima

    2013-01-01

    133 f. Estudo do universo de representação das personagens homoeróticas em contos de Reinaldo Arenas, David Leavitt e João Silvério Trevisan, escritores gueis assumidos. Após contextualizar o espaço geográfico e simbólico em que os três atuam, a construção das diferentes Américas enquanto “paraíso terrestre”, lugar de igualdade, justiça e liberdade, e tentar demonstrar o corte epistemológico que a noção de homoerotismo sofreu com o movimento de emancipação guei de Stonewall – inicialmente,...

  3. Between a Rock and a Blue Chair: David Hockney’s Rocky Mountains and Tired Indians (1965

    Directory of Open Access Journals (Sweden)

    Martin Hammer

    2017-04-01

    Full Text Available Travel and cultural exchange between the United Kingdom and the United States of America became a key feature of the 1960s, shaping the world view of many a British artist, curator, architect, writer, film-maker, and academic. Against that wider backdrop, I offer here a focused reading of David Hockney’s 1965 painting, Rocky Mountains and Tired Indians. With its faux-naive idiom and overt but quirkily un-modern American theme, the work conveys the artist’s singular take on what it felt like to be a Brit at large in the US, an environment at once wondrously exotic and at times strikingly banal. Close analysis discloses Hockney’s rich repertoire of artistic and literary allusions in Rocky Mountains, and the meanings and associations these may have encapsulated.

  4. “I Kept Saying Her Name”: Naming, Labels and Power in the Early Writing of David Foster Wallace

    Directory of Open Access Journals (Sweden)

    Clare Hayes-Brady

    2017-03-01

    Full Text Available Among the most immediately striking features of David Foster Wallace’s writing is his use of names. Ranging from broad comedy to philosophical and cryptic signposting, the ways Wallace names his characters, and, just as significantly, the ways his characters name themselves and each other, are central to the development of identity, and to the appropriation and exercise of power. The forms and relationships of nomination in Wallace’s fiction speak to a range of his primary artistic concerns, and a reading of these interactions sheds light on both the intricate narrative structures and the grounding ideologies of his writing. This essay traces some of the patterns in these nominative practices, arguing that an onomastic reading of Wallace’s work traces the sometimes less than clear connection between the broad comic style that marks his early work in particular and the profound philosophical engagement undertaken throughout his career.

  5. Preferential Consideration: Bartleby, Class, and Genocide in David Foster Wallace’s “Consider the Lobster”

    Directory of Open Access Journals (Sweden)

    Martin Paul Eve

    2017-12-01

    Full Text Available This article presents the case for reading Herman Melville’s “Bartleby the Scrivener” as a key intertext for David Foster Wallace’s 2004 essay, “Consider the Lobster”. Focusing upon Wallace’s assertion that “it may well be that an ability to form preferences is the decisive criterion for real suffering” the piece reads Wallace’s work through the lenses of capital, class, political aesthetics, ecology, and genocide. Ultimately, though, this article argues that Wallace’s essay ends with ethical stalemate since Wallace is unwilling to commit to a political stance. It is, as I here argue, as though Wallace’s essay would “prefer not to” make an actual decision.

  6. Last Words: David's Mars Disarmed by Venus and the Graces (1824. Subjectivity, Death, and Postrevolutionary Late Style

    Directory of Open Access Journals (Sweden)

    Padiyar, Satish

    2011-06-01

    Full Text Available Completed as he was approaching death in 1825, Jacques-Louis David's final refractory history painting is an intricate summation of a life in politics and painting. The article attempts to re-interpret the canvas in relation to the dual problem of 'late style' and the condition of exile. I argue that this history painting invokes the metaphor of non-sex for the condition of exile; and as a late gesture stages an anomalous return to a pre-lapsarian eighteenth century. The painting, I conclude, reveals less the transcendent subjectivity of an artist approaching biological death, than the critical disarming of a once-radical neoclassical aesthetic itself, in its tragic late phase.

  7. Riesgo coronario según ecuación de Framingham en adultos con síndrome metabólico de la ciudad de Soledad, Atlántico. 2010

    Directory of Open Access Journals (Sweden)

    Edgar Navarro, MD., MSc.

    2012-05-01

    Resultados y conclusiones: 49,5% de los sujetos tenían síndrome metabólico según la International Diabetes Foundation (IDF, 41,4% de acuerdo con la American Heart Asociation (AHA y 20,2% con base en el Adult Treatment Panel III (ATP III. La prevalencia de síndrome metabólico fue mayor en mujeres (p>0,05; por edad se encontraron diferencias estadísticamente significativas (p<0,05. El promedio de porcentaje de riesgo cardiovascular según Framingham fue de 3% (DE ±: 4,72%, mayor en los hombres: 5,67 (DE ±: 5,24 frente a 1,01 (DE±: 3,04 en mujeres. En los hombres con síndrome metabólico el riesgo cardiovascular fue mayor.

  8. La mujer en el radiador en Cabeza borradora (Eraserhead, 1972-1976) de David Lynch: disección utópica del ojo

    OpenAIRE

    Villaplana Ruiz, Virginia

    1998-01-01

    Villaplana, V. (1998). La mujer en el radiador en Cabeza borradora (Eraserhead, 1972-1976) de David Lynch: disección utópica del ojo. Banda aparte. (11):29-31. http://hdl.handle.net/10251/43165. 29 31 11

  9. Een liefdespaar onthuld: Jacob Adriaensz Backer's zogenoemde 'David en Bathseba' opnieuw geïdentificeerd als 'Isaäk en Rebekka'

    NARCIS (Netherlands)

    Kok, E.

    2011-01-01

    Jacob Backer signed and dated (1640) a history piece that until now was entitled David and Bathsheba and is located in Tokyo. The image however, lacks the traditional iconographical motifs from which we can recognize this old biblical story.In this article I propose that the painting is a portrait

  10. Power Play: The Dynamics of Power and Interpersonal Communication in Higher Education as Reflected in David Mamet's "Oleanna"

    Science.gov (United States)

    Chiaramonte, Peter

    2014-01-01

    David Mamet's play "Oleanna" may be infamous for reasons that do not do justice to the play's real accomplishments. One reason for the controversy is the author's apparent focus on sexual harassment. The play is not about sexual harassment. It is about power. And in particular the power of language to shape relationships…

  11. "In the Hands of the Receivers": The Politics of Literacy in "The Savage" by David Almond and Dave McKean

    Science.gov (United States)

    Hateley, Erica

    2012-01-01

    David Almond and Dave McKean's "The Savage" is a hybrid prose and graphic novel which tells the story of one young man's maturation through literacy. The protagonist learns to deal with the death of his father and his own "savage" self by writing a graphic novel. This article reads "The Savage" in the context of earlier, "Northern" literacy…

  12. "Neither Can They Die Any More; for They Are Equal Unto the Angels": Secular Epiphanies in David Almond's "Counting Stars"

    Science.gov (United States)

    Grace, Deborah

    2014-01-01

    Written before the successful publication of Skellig (1998), David Almond's short story collection, "Counting Stars," has attracted less critical attention than his more famous novels. Falling between fiction and autobiography, the earlier short stories are more firmly grounded in realism than the novels, which feature elements of…

  13. A Proposed Theoretical Model Using the Work of Thomas Kuhn, David Ausubel, and Mauritz Johnson as a Basis for Curriculum and Instruction Decisions in Science Education.

    Science.gov (United States)

    Bowen, Barbara Lynn

    This study presents a holistic framework which can be used as a basis for decision-making at various points in the curriculum-instruction development process as described by Johnson in a work published in 1967. The proposed framework has conceptual bases in the work of Thomas S. Kuhn and David P. Ausubel and utilizes the work of several perceptual…

  14. Critical Terrorism Studies Since 11 September 2001: What Has Been Learned? Edited by David Miller, Jessie Blackbourn, Rani Dhanda and Helen Dexter. New York, NT: Routledge, 2014.

    Directory of Open Access Journals (Sweden)

    Mark Roberts

    2014-04-01

    Full Text Available Critical Terrorism Studies Since 11 September 2001: What Has Been Learned? Edited by David Miller, Jessie Blackbourn, Rani Dhanda and Helen Dexter. New York, NT: Routledge, 2014. ISBN 978-0-415-83852-8. Graphs. Tables. Sources cited. Index. Pp. viii, 144. $137.75.

  15. The outcome after aortic valve-sparing (David) operation in 179 patients: a single-centre experience.

    Science.gov (United States)

    Leontyev, Sergey; Trommer, Constanze; Subramanian, Sreekumar; Lehmann, Sven; Dmitrieva, Yaroslava; Misfeld, Martin; Mohr, Friedrich W; Borger, Michael A

    2012-08-01

    The David aortic valve-sparing reimplantation (AVr-D) operation is increasingly being used in patients with aortic root aneurysmal disease and pliable aortic cusps. The objective of this study was to assess our early and medium-term outcomes with the AVr-D operation. Between 2003 and 2011, a total of 179 patients underwent AVr-D procedures. The mean patient age was 49.7 ± 15.1 years, and 23.5% (n = 42) were females. Marfan syndrome was present in 17.3% of patients (n = 31), and acute Type A aortic dissection in 15.6% (n = 28). Clinical follow-up was 100% complete and was 1.8 ± 1.6 years (0 days to 7.5 years) long. Echocardiographic follow-up was performed 2.2 ± 1.5 years (0 days to 7.5 years) postoperatively and was 77% complete. Early mortality was 1.1% (n = 2), with both deaths occurring in patients with Type A dissection. Pre-discharge echocardiography revealed no patients with >2+ aortic insufficiency (AI), 19.6% of patients (n = 34) with 1+ or 2+ AI and 80.4% of patients (n = 145) with trace or no AI. Left ventricular end-diastolic diameters decreased significantly from 5.6 ± 0.9 to 5.1 ± 0.8 cm early postoperatively (P valve re-replacement during follow-up, two due to early endocarditis and two due to non-coronary leaflet prolapse in Marfan patients. Five-year freedom from aortic valve reoperation was 95.9 ± 2.0%. AVr-D is associated with a low mortality and morbidity rate, even in patients with Type A aortic dissection. Although a slightly higher rate of recurrent AI may be present in patients with Marfan syndrome, freedom from recurrent AI and reoperation remains excellent during medium-term follow-up. The David operation should be considered the gold standard for patients with proximal aortic root pathology (aneurysm or dissection) and pliable aortic cusps.

  16. Is Mass Society a Threat to Representative Democracy? Revisiting David Riesman’s “Other-Directed Character”

    Directory of Open Access Journals (Sweden)

    Pekka Sulkunen

    2012-07-01

    Full Text Available Representative democracy has been based on the idea that interest groups form parliaments through competitive elections, and legislate in favour of their supporters. Declining electoral participation, rise of populist rightwing parties, contingent coalitions, personalized electoral success and scandaldriven politics indicate a crisis in representative democracy. Mass society theories after the Second World War predicted a decline of democracy on the basis of homogenisation of mass consumption societies. The threat was seen to involve totalitarian rule, combined with bureaucracy serving the interests of elites. This paper examines the underlying presuppositions of mass society theory, and argues that the homogeneity argument is insufficient to fit the realities. Following David Riesman, it is argued that the otherdirected character growsfrom unstable interest group identities, but its determinant is not sameness but agency and therefore difference. To have agency is to orient oneself to others as a self, as unique, separate and autonomous subject. This is vindicated by trends in public administration since the 1980s, which stress citizens’ selfcontrol,autonomy and partnership rather than conformity. Political disputes arise around contradictions between difference and autonomy in societies where agency is a principle of justification. Universal autonomy requires homogeneity but agency stresses difference and uniqueness.

  17. Expanding the body mass range: associations between BMR and tissue morphology in wild type and mutant dwarf mice (David mice).

    Science.gov (United States)

    Meyer, Carola W; Neubronner, Juliane; Rozman, Jan; Stumm, Gabi; Osanger, Andreas; Stoeger, Claudia; Augustin, Martin; Grosse, Johannes; Klingenspor, Martin; Heldmaier, Gerhard

    2007-02-01

    We sought to identify associations of basal metabolic rate (BMR) with morphological traits in laboratory mice. In order to expand the body mass (BM) range at the intra-strain level, and to minimize relevant genetic variation, we used male and female wild type mice (C3HeB/FeJ) and previously unpublished ENU-induced dwarf mutant littermates (David mice), covering a body mass range from 13.5 g through 32.3 g. BMR was measured at 30 degrees C, mice were killed by means of CO(2 )overdose, and body composition (fat mass and lean mass) was subsequently analyzed by dual X-ray absorptiometry (DEXA), after which mice were dissected into 12 (males) and 10 (females) components, respectively. Across the 44 individuals, 43% of the variation in the basal rates of metabolism was associated with BM. The latter explained 47% to 98% of the variability in morphology of the different tissues. Our results demonstrate that sex is a major determinant of body composition and BMR in mice: when adjusted for BM, females contained many larger organs, more fat mass, and less lean mass compared to males. This could be associated with a higher mass adjusted BMR in females. Once the dominant effects of sex and BM on BMR and tissue mass were removed, and after accounting for multiple comparisons, no further significant association between individual variation in BMR and tissue mass emerged.

  18. Urban common space, heterotopia and the right to the city: Reflections on the ideas of Henri Lefebvre and David Harvey

    Directory of Open Access Journals (Sweden)

    Orlando Alves dos Santos Junior

    2014-05-01

    Full Text Available A city’s common spaces are appropriated by capital that aims to guarantee the conditions necessary for the production-reproduction of capitalist relations. In this context, the challenge is to imagine and construct a very different type of city capable of breaking away from the dynamic of capital, founded on new forms of appropriation of the city, which implies articulating both theory and praxis. For this to occur, however, it is necessary to create new knowledge about the city and a strong anti-capitalist social movement focused on the transformation of daily urban life and involving new forms of appropriation of urban common spaces. It is in this context, and from a dialectic perspective, that this article articulates the ideas of Henri Lefebvre and David Harvey, seeking to contribute to an understanding of the production processes of space in contemporary capitalism, the discussion of the future of cities and perspectives on transition. To do so, the article addresses four central ideas: (i the dialectic conception of space to problematize the production and appropriation of urban common spaces; (ii the recognition of urban common spaces as spaces traversed by contradictions, disputes and material and symbolic conflicts among different agents; (iii the right to the city as a need and as a utopian project; and (iv the challenge of articulating heterotopic practices from the perspective of creative rebellion for the right to the city and the transition to a new urban future.

  19. The E-pistolary Novel: Print Screens of Media-driven Thoughts in David Llewellyn’s Eleven

    Directory of Open Access Journals (Sweden)

    Oana Celia GHEORGHIU

    2014-12-01

    Full Text Available Contemporary literature seems to have reconciled the idea that everything valuable has already been said and done and, as such, has wilfully inscribed itself in a never-ending cycle of narratives about narratives, in a process of recycling and updating the past, which some love to name postmodernist. What is left at stake is simply the consumerist need to produce an oxymoronic ‘original copy’: to launch that piece of literature unseen and unheard of before on a crowded book market. A recipe for success seems to be the ability to combine the novelty of the architectural design – the formal innovation – with the thematisation of the present. It is precisely what the young Welsh novelist and scriptwriter, David Llewellyn, achieves with his debut novel, Eleven. In an attempt to translate the old into the new, Eleven is constructed following the design of the early modern epistolary novels, yet making use of a contemporary mode of writing: the email. Thematically, it is an exploration of patterns of individual thinking shaped by the media, against the background of an event with global consequences, which is, nevertheless, viewed from afar, without the inherent trauma so visible in American post-9/11 fiction. The present paper aims at analysing the construction of the novel, including the linguistic transformations it employs, and at accounting for the identitaryrevolt that transpires from the e mails exchanged between various character-narrators on an apparently ordinary day: September 11, 2001.

  20. Sex-Age Related Rumination Behavior of Père David's Deer under Constraints of Feeding Habitat and Rainfall.

    Directory of Open Access Journals (Sweden)

    Zhongqiu Li

    Full Text Available Extensive studies have been conducted on the rumination behavior of domestic herbivores. However, studies on wild animals are limited, particularly wild animals with specific ruminating parameters. In this study, Père David's deer, a previously extirpated species, was observed to analyze the effects of sex-age, feeding habitat, and rainfall on rumination behavior in the Dafeng Nature Reserve, China. Rumination behavior was investigated based on four parameters: proportion of bedding time spent chewing, bolus processing time (s/bolus, chewing frequency (chews/bolus, and chewing rate (chews/s. Results showed that all three factors affect rumination behavior. The extent of their effects varied based on the four rumination parameters. Chewing rate and frequency decreased based on sex-age levels, i.e., from fawns to juvenile female, juvenile male, adult female, stag, and harem holder. Therefore, body size played a major role in shaping rumination behavior. Deer found in grasslands could chew faster compared with deer found in woodlands. This result might be caused by the effects of dietary composition and sunlight intensity. A deer spends a longer time ruminating while bedding during rainy days compared with rainless days to maximize energy and nutrition intake and compensate for the loss of feeding time during rainy days. Therefore, rumination behavior is plastic and is shaped by intrinsic and extrinsic factors.

  1. Valve-sparing David I procedure in acute aortic type A dissection: a 20-year experience with more than 100 patients.

    Science.gov (United States)

    Beckmann, Erik; Martens, Andreas; Pertz, Jana; Kaufeld, Tim; Umminger, Julia; Hanke, Jasmin S; Schmitto, Jan D; Cebotari, Serghei; Haverich, Axel; Shrestha, Malakh Lal

    2017-08-01

    The aortic valve-sparing David procedure has been applied to the elective treatment of patients with aortic aneurysms with excellent results. The use of this technique in patients with acute aortic dissection type A (AADA) is still a matter of debate. We present our long-term experience with 109 patients with AADA who had the valve-sparing David I procedure. Between July 1993 and October 2015, 109 patients with AADA had the valve-sparing David I procedure at our centre. We conducted a retrospective review with follow-up. The mean age was 54 ± 12 years; 78 (72%) patients were men. Marfan syndrome was present in 6 (5%) patients and bicuspid aortic valve in 3 (3%). Only 4 (4%) patients received the isolated David procedure; 50 (46%) underwent additional proximal, 13 (12%) subtotal and 42 (39%) total aortic arch replacement. The in-hospital mortality rate was 11% ( n  = 12). Intraoperative/discharge echocardiography showed aortic insufficiency ≤ I° in 93 of 97 patients (96%). Mean follow-up time was 8.3 ± 5.7 years. The survival rate after discharge at 1, 5 and 10 years was 94%, 90% and 78%, respectively. Thirteen percent ( n  = 13) of patients underwent valve-related reoperation. Freedom from valve-related reoperation at 1, 5 and 10 years was 96%, 88% and 85%, respectively. Compared to patients who underwent the David I procedure for any reason other than AADA, there were no significant differences in long-term survival rates ( P  = 0.29) and freedom from a valve-related reoperation ( P  = 0.39). The valve-sparing David I procedure has acceptable long-term results even in emergent operations for AADA and is not inferior when performed in elective settings. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  2. New software for computer-assisted dental-data matching in Disaster Victim Identification and long-term missing persons investigations: "DAVID Web".

    Science.gov (United States)

    Clement, J G; Winship, V; Ceddia, J; Al-Amad, S; Morales, A; Hill, A J

    2006-05-15

    In 1997 an internally supported but unfunded pilot project at the Victorian Institute of Forensic Medicine (VIFM) Australia led to the development of a computer system which closely mimicked Interpol paperwork for the storage, later retrieval and tentative matching of the many AM and PM dental records that are often needed for rapid Disaster Victim Identification. The program was called "DAVID" (Disaster And Victim IDentification). It combined the skills of the VIFM Information Technology systems manager (VW), an experienced odontologist (JGC) and an expert database designer (JC); all current authors on this paper. Students did much of the writing of software to prescription from Monash University. The student group involved won an Australian Information Industry Award in recognition of the contribution the new software could have made to the DVI process. Unfortunately, the potential of the software was never realized because paradoxically the federal nature of Australia frequently thwarts uniformity of systems across the entire country. As a consequence, the final development of DAVID never took place. Given the recent problems encountered post-tsunami by the odontologists who were obliged to use the Plass Data system (Plass Data Software, Holbaek, Denmark) and with the impending risks imposed upon Victoria by the decision to host the Commonwealth Games in Melbourne during March 2006, funding was sought and obtained from the state government to update counter disaster preparedness at the VIFM. Some of these funds have been made available to upgrade and complete the DAVID project. In the wake of discussions between leading expert odontologists from around the world held in Geneva during July 2003 at the invitation of the International Committee of the Red Cross significant alterations to the initial design parameters of DAVID were proposed. This was part of broader discussions directed towards developing instruments which could be used by the ICRC's "The Missing

  3. La representación de los personajes monstruosos en el cine de David Lynch: Cabeza Borradora y El Hombre Elefante

    OpenAIRE

    Suñer Royo, Iris

    2015-01-01

    Treball final de Grau en Comunicació Audiovisual. Codi: CA0932. Curs acadèmic 2014-2015 El universo creado por David Lynch es prácticamente inabarcable, sin embargo, con cada producto que realiza incorpora nuevas estrategias expresivas y formales que podemos desglosar y analizar para entender cada vez mejor como su mente y creatividad se desarrollan. Para ello hemos empezado desde el principio, por sus dos primeros largometrajes, los cuales son los únicos filmados en blanco ...

  4. A novel HURRAH protocol reveals high numbers of monomorphic MHC class II loci and two asymmetric multi-locus haplotypes in the Père David's deer.

    Directory of Open Access Journals (Sweden)

    Qiu-Hong Wan

    Full Text Available The Père David's deer is a highly inbred, but recovered, species, making it interesting to consider their adaptive molecular evolution from an immunological perspective. Prior to this study, genomic sequencing was the only method for isolating all functional MHC genes within a certain species. Here, we report a novel protocol for isolating MHC class II loci from a species, and its use to investigate the adaptive evolution of this endangered deer at the level of multi-locus haplotypes. This protocol was designated "HURRAH" based on its various steps and used to estimate the total number of MHC class II loci. We confirmed the validity of this novel protocol in the giant panda and then used it to examine the Père David's deer. Our results revealed that the Père David's deer possesses nine MHC class II loci and therefore has more functional MHC class II loci than the eight genome-sequenced mammals for which full MHC data are currently available. This could potentially account at least in part for the strong survival ability of this species in the face of severe bottlenecking. The results from the HURRAH protocol also revealed that: (1 All of the identified MHC class II loci were monomorphic at their antigen-binding regions, although DRA was dimorphic at its cytoplasmic tail; and (2 these genes constituted two asymmetric functional MHC class II multi-locus haplotypes: DRA1*01 ∼ DRB1 ∼ DRB3 ∼ DQA1 ∼ DQB2 (H1 and DRA1*02 ∼ DRB2 ∼ DRB4 ∼ DQA2 ∼ DQB1 (H2. The latter finding indicates that the current members of the deer species have lost the powerful ancestral MHC class II haplotypes of nine or more loci, and have instead fixed two relatively weak haplotypes containing five genes. As a result, the Père David's deer are currently at risk for increased susceptibility to infectious pathogens.

  5. David N. Reznick's The " Origin" Then and Now: An Interpretive Guide to the " Origin of Species": A Précis

    Science.gov (United States)

    Ruse, Michael

    2013-09-01

    David Reznick is one of the world's leading evolutionary biologists. His book on Charles Darwin's Origin of Species is given here in a précis, in order to show the underlying approach that he takes towards a work that is a classic in his field. It is shown that Reznick's interests are less in Darwin for his own sake and more in the importance of Darwin's ideas for science today.

  6. Diversidad de insectos acuáticos y calidad del agua de los ríos David y Mula, provincia de Chiriquí, Panamá.

    Directory of Open Access Journals (Sweden)

    Tomás Ríos

    2015-06-01

    Full Text Available Se determinó la diversidad, abundancia, distribución, riqueza de insectos acuáticos y la calidad del agua en los ríos David y Mula, en época seca (enero-abril y lluviosa (julio-octubre en el año 2010. Los insectos acuáticos se recolectaron dos veces al mes y se utilizaron tres métodos de captura, de acuerdo con el tipo de sustrato. Se identificaron 82 géneros (cuatro sin determinar, agrupados en 43 familias y nueve órdenes de la clase Insecta, con una abundancia total de 14.951 individuos. El río David presentó una diversidad (H’ entre 2,17 y 2,87, y el río Mula entre 2,73 y 2,90. El índice de similitud de Sorensen mostró valores altos de similitud. Según el índice BMWP’/Pan, los ríos David y Mula mostraron aguas de calidad buena o no alteradas de manera sensible a aguas de calidad excelente, excepto en un sitio del río David donde el agua fue de calidad regular, eutrófica y moderadamente contaminada en la época lluviosa. En ambos ríos los datos indican una constancia de los niveles de pH, oxígeno disuelto y conductividad, y además, no presentan cambios significativos notables durante las épocas seca y lluviosa.

  7. Decolonizing Alliances: Afro-Asian Choreographies by David Rouss�ve/REALITY and Ananya Chatterjea/Ananya Dance Theatre

    OpenAIRE

    Williams, Alessandra

    2016-01-01

    This dissertation demonstrates how diasporic practice experiments with cultural forms of communities of African and Asian descent for decolonizing purposes, or radically transforms systemically oppressive politics on nation, race, gender, and sexuality. Through case studies of two transnational dance companies known as the Los Angeles-based REALITY and Minneapolis-based Ananya Dance Theatre and their respective choreographers David Rouss�ve and Ananya Chatterjea, I discuss how choreographie...

  8. Work plan for the removal and subsequent management of specific waste from David Witherspoon, Inc., Knoxville, Tennessee

    International Nuclear Information System (INIS)

    1993-01-01

    The Tennessee Department of Environment and Conservation (TDEC) and the Department of Energy (DOE) have made the determination that approximately 258 drums of waste and 10 open-top boxes of waste now located at the site known as David Witherspoon, Inc., (DWI) in south Knoxville, Tennessee, should be repackaged as necessary and transferred to the K-25 Site in Oak Ridge, Tennessee, for management. This work plan addresses the four phases of activity planned and the methods of accomplishment The lint phase will consist of an assessment to determine requirements for managing the waste. Items to be investigated include site access, site conditions, personal protective equipment, waste characterization needs, packaging and labeling, transportation, receipt and storage of the waste at the K-25 Site, and site controls and monitoring required during the packaging operations to be conducted at DWI. The second phase will include mobilization of on-site support and operating facilities, sampling and transferral of a randomly selected representative fraction of the 232 drums now stored on-site in sea/land containers to storage facilities at the K-25 Site, and sampling of the waste now stored in the 26 drums inside the main process building and the 10 open-top boxes of waste stored outside and adjacent to the building. The third phase will include repackaging and transferral of the 26 drums and 10 boxes of waste to the K-25 Site and placement of the containerized waste into appropriate storage at the K-25 Site. Participants in the fourth phase of activity will demobilize the support and operating facilities from DWI, conduct an on-site evaluation at the K-25 site to verify compliance with storage and other management requirements, prepare a closeout report for the activity assessing the actions, and develop a plan for the final management method for the waste

  9. Incidence and progression of mild aortic regurgitation after Tirone David reimplantation valve-sparing aortic root replacement.

    Science.gov (United States)

    Stephens, Elizabeth H; Liang, David H; Kvitting, John-Peder Escobar; Kari, Fabian A; Fischbein, Michael P; Mitchell, R Scott; Miller, D Craig

    2014-01-01

    The study objective was to determine whether recurrent or residual mild aortic regurgitation, which occurs after valve-sparing aortic root replacement, progresses over time. Between 2003 and 2008, 154 patients underwent Tirone David-V valve-sparing aortic root replacement; 96 patients (62%) had both 1-year (median, 12 ± 4 months) and mid-term (62 ± 22 months) transthoracic echocardiograms available for analysis. Age of patients averaged 38 ± 13 years, 71% were male, 31% had a bicuspid aortic valve, 41% had Marfan syndrome, and 51% underwent aortic valve repair, predominantly cusp free margin shortening. Forty-one patients (43%) had mild aortic regurgitation on 1-year echocardiogram. In 85% of patients (n = 35), mild aortic regurgitation remained stable on the most recent echocardiogram (median, 57 ± 20 months); progression to moderate aortic regurgitation occurred in 5 patients (12%) at a median of 28 ± 18 months and remained stable thereafter; severe aortic regurgitation developed in 1 patient, eventually requiring reoperation. Five patients (5%) had moderate aortic regurgitation at 1 year, which did not progress subsequently. Two patients (2%) had more than moderate aortic regurgitation at 1 year, and both ultimately required reoperation. Although mild aortic regurgitation occurs frequently after valve-sparing aortic root replacement, it is unlikely to progress over the next 5 years and should not be interpreted as failure of the valve-preservation concept. Further, we suggest that mild aortic regurgitation should not be considered nonstructural valve dysfunction, as the 2008 valve reporting guidelines would indicate. We need 10- to 15-year follow-up to learn the long-term clinical consequences of mild aortic regurgitation early after valve-sparing aortic root replacement. Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

  10. David Fiander (1931 - 2015)

    CERN Multimedia

    2015-01-01

    It was with shock and sorrow that we heard that Dave Fiander had passed away on 29 March.    Dave was born in London in 1931 and educated in a number of schools in Wales, finishing up in Swansea. He studied Engineering at Imperial College London – a university which has always enjoyed a premier reputation in the subject. After graduation he worked for several years for the United Kingdom Atomic Energy Authority, where he worked on the production of enriched uranium fuel rods for nuclear power stations. In 1963, he was offered a job at CERN and joined a group in the PS Division headed by Fred Asner and responsible for injection and ejection systems. This was an exciting time for CERN. Europe’s first large synchrotron, the PS, had been completed and had begun to accelerate bunches of protons to a world record energy of 28 GeV. Once accelerated, the 25 bunches of particles circulated at intervals of 110 ns around the 100-metre-radius circle that was the PS accelerato...

  11. Eesti hirmuvabaks! / David Vseviov

    Index Scriptorium Estoniae

    Vseviov, David, 1949-

    2011-01-01

    Erinevalt parteiliikmetest saab üksikkandidaadina valitu Riigikogus hääletada vabast tahtest lähtudes ja karistushirmu tundmata. Me ei peaks panustama lootusele, et üks inimene osutub paljudest teistest vabamaks ja julgemaks, vaid sellele, et arvamuste väljendamine ja hirmuvaba otsustamine on Eestis norm

  12. David J. Feldman | NREL

    Science.gov (United States)

    Analysis Center. Areas of Expertise Renewable energy project finance Corporate finance Solar energy market policy Corporate finance in energy sector Education M.B.A. from the Yale School of Management, New Haven Finance, Soltage, Jersey City, NJ (2007-2010) Associate, The Jordan Edmiston Group, New York, NY (2006

  13. David Mooney | NREL

    Science.gov (United States)

    expertise Strategic planning Broad knowledge base in technologies and markets for energy technologies and their integration into the current energy infrastructure Technical and operational knowledge of the photovoltaics technologies and industry Design and cost analysis of concentrating solar power system

  14. David Owen WILLIAMS

    CERN Multimedia

    2006-01-01

    Lidy Williams-Oonk and her children Mark & Marietta, being unable to thank everybody individually, would like to express their sincere thanks to friends and colleagues at CERN and abroad for their great help and support, their messages and flowers, as well as their donations to the Ligue Genevoise contre le Cancer, on the death of their beloved husband and father.

  15. David Snowberg | NREL

    Science.gov (United States)

    . His expertise includes test equipment design, test method development, measurement uncertainty, and the management of blade test projects. He also works with the NREL Marine Hydrokinetic group in the

  16. Poleemika / David Elliott

    Index Scriptorium Estoniae

    Elliott, David

    1998-01-01

    Stockholmi Moodsa Kunsti Muuseumi direktor D. Elliott sellest, kuidas ta inglise kunstiteadlasena tunneb end Rootsi ühe olulise kunstiinstitutsiooni juhina, väljapaistvate kunstiteadlaste rotatsioonist.

  17. Reviews / David J. Smith

    Index Scriptorium Estoniae

    Smith, David J.

    2012-01-01

    Arvustus: Kasekamp, Andres. A history of the Baltic states. Basingstoke (Hampshire) ; New York : Palgrave Macmillan, 2010. Artiklis tutvustatakse raamatut eelkõige kui täielikku ülevaadet Balti riikide postsotsialistlikust edukast arengust ja selle ajaloolistest juurtest

  18. David et al (12)

    African Journals Online (AJOL)

    DELL

    larger mesophyll cells, xylem tissues, vascular bundles and bundle sheaths than other cultivars. Thus, larger ... mechanism to cope with drought stress. There was an ... where solar radiation is intense (Løe et al., 2007). Most ecological studies ...

  19. David Rager | NREL

    Science.gov (United States)

    the architecture and development of cloud, web, software, data processing and storage systems. As part Technology, Colorado Technical University, Denver, Colorado, 2004 Master of Business Administration, Colorado Business Analytics Manager, Digital First Media, Denver, Colorado, 2 years Cloud Architect and Developer

  20. Cloud amount/frequency, NITRATE and other data from NOAA Ship DAVID STARR JORDAN in the NE Pacific from 1974-05-29 to 1974-06-05 (NODC Accession 8600114)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — High resolution CTD data was collected from NOAA Ship DAVID STARR JORDAN cruise 86 and other platforms. The data was collected by National Marine Fisheries Service,...

  1. Cloud amount/frequency, NITRATE and other data from NOAA Ship DAVID STARR JORDAN in the NE Pacific from 1971-07-01 to 1971-07-12 (NODC Accession 8100361)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Conductivity, temperature and Depth probe was used to collect data from NOAA Ship DAVID STARR JORDAN. The data were collected from NE Pacific (limit-180) over 12...

  2. BAROMETRIC PRESSURE and Other Data from NOAA Ship DAVID STARR JORDAN and Other Platforms From Coastal Waters of California from 1987-04-10 to 1994-05-23 (NODC Accession 9400150)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Conductivity, Temperature and Depth (CTD) and other data were collected in Coastal Waters of California by NOAA Ship DAVID STARR JORDAN. Data were collected over a...

  3. Underway physical and meteorological data collected aboard NOAA Ship DAVID STARR JORDAN in the North Pacific from 2004-07-12 to 2004-08-11 (NODC Accession 0001682)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature, pressure, conductivity, salinity, bottom depth, and other data were collected using meteorological sensors, and thermosalinograph from NOAA Ship DAVID...

  4. Right Ventricular Volumes and Systolic Function by Cardiac Magnetic Resonance and the Impact of Sex, Age, and Obesity in a Longitudinally Followed Cohort Free of Pulmonary and Cardiovascular Disease: The Framingham Heart Study.

    Science.gov (United States)

    Foppa, Murilo; Arora, Garima; Gona, Philimon; Ashrafi, Arman; Salton, Carol J; Yeon, Susan B; Blease, Susan J; Levy, Daniel; O'Donnell, Christopher J; Manning, Warren J; Chuang, Michael L

    2016-03-01

    Cardiac magnetic resonance is uniquely well suited for noninvasive imaging of the right ventricle. We sought to define normal cardiac magnetic resonance reference values and to identify the main determinants of right ventricular (RV) volumes and systolic function using a modern imaging sequence in a community-dwelling, longitudinally followed cohort free of clinical cardiovascular and pulmonary disease. The Framingham Heart Study Offspring cohort has been followed since 1971. We scanned 1794 Offspring cohort members using steady-state free precession cardiac magnetic resonance and identified a reference group of 1336 adults (64±9 years, 576 men) free of prevalent cardiovascular and pulmonary disease. RV trabeculations and papillary muscles were considered cavity volume. Men had greater RV volumes and cardiac output before and after indexation to body size (all Pheart rate account for most of the variability in RV volumes and function in this community-dwelling population. We report sex-specific normative values for RV measurements among principally middle-aged and older adults. RV ejection fraction is greater in women. RV volumes increase with body size, are greater in men, and are smaller in older people. Body surface area seems to be appropriate for indexation of cardiac magnetic resonance-derived RV volumes. © 2016 American Heart Association, Inc.

  5. Fuel to the nuclear debate : [Rezension von:] Nuclear power in crisis, Andrew Blowers and David Pepper (editors), New York, Nichols; London ..., Croom Helm, 1987

    OpenAIRE

    Renn, Ortwin

    1988-01-01

    Nuclear energy is one of the most popular topics of today’s publication market. The literature about the pros and cons of nuclear power may easily fill a whole library. Is there anything new to add to this voluminous body of arguments and contra-arguments that would justify editing another book on nuclear energy? Andrew Blowers and David Pepper obviously felt that way and published a reader on Nuclear Power in Crisis. The book consists of 13 articles covering mainly the political, social and ...

  6. Stepping backwards with disability humor? The case of NY Gov. David Paterson’s representation on ‘Saturday Night Live’

    OpenAIRE

    Beth Haller; Amy Bree Becker

    2014-01-01

    In the modern era, discerning TV viewers know the shows that trade in cheap laughs by making fun of people with disabilities are not tapping into much creativity. So it was a surprise in 2008 when the highly regarded comedy show Saturday Night Live (SNL) stooped to that level by ridiculing the blind governor of New York, David Paterson, in a series of sketches lasting two years. This article analyzes the way humor narratives about a high-profile blind politician on television, like those depi...

  7. Local knowledge, state power, and the science of industrial labor relations: William Leiserson, David Saposs, and American labor economics in the interwar years.

    Science.gov (United States)

    Wang, Jessica

    2010-01-01

    Recent scholarship has frequently emphasized modern states' use of social science to impose universalized conceptions of rationality and order upon diverse, highly localized settings. The New Deal era experiences of William M. Leiserson and David J. Saposs, however, provide an analytical alternative. As students of the pioneering labor economist John R. Commons, Leiserson and Saposs sought to create mechanisms for state oversight of industrial labor relations that recognized local practices and arrangements. Although their approach failed to take hold within the National Labor Relations Board, localized institutional and political contingencies, and not a hegemonic modernism, account best for their frustrated aspirations in the late 1930s. © 2010 Wiley Periodicals, Inc.

  8. Los Supuestos Metafísicos del Problema de la Experiencia Consciente en la Filosofía de David Chalmers

    OpenAIRE

    Fontcuberta Llavata, Alejandro

    2016-01-01

    El problema difícil de la experiencia consciente se resume en la cuestión de cómo es posible que el cerebro sea la base de la experiencia consciente. El objetivo general de la tesis es llevar a cabo una crítica general de los supuestos metafísicos que subyacen a la formulación del problema difícil de la experiencia consciente, centrándose en el análisis que se lleva a cabo del problema en la obra de David Chalmers. Los argumentos presentados tratan de establecer tres clases de resultados que ...

  9. Gossip as a Channel for Circulating Subversive Truth: In Heym's The King David Report, the GDR and the Jardin du Luxembourg

    Directory of Open Access Journals (Sweden)

    David Fishelov

    2014-04-01

    Full Text Available Dans la Chronique du roi David (1991 , Stefan Heym (1913-2001 propose une perspective favorable sur le potin, nonobstant la censure biblique de cette activité (ex : Proverbe 11:13. La réécriture satirique de Heym de l'histoire biblique se concentre sur le personnage d’Ethan, un écrivain-historien nommé par le roi Salomon pour composer un rapport officiel sur la vie et l’arrivée au pouvoir du roi David. À un moment donné les deux fils d’Ethan, Sem et Sheleph, reviennent du marché et racontent à Ethan certaines rumeurs «savoureuses» qu'ils y ont entendues. Ces rumeurs, tandis qu’elles sont un peu exagérées et embellies, fournissent toutefois des aperçus de la situation politique qui sont beaucoup plus fidèles à la vérité que les inventions des porte-parole officiels. Pour justifier le portrait littéraire de Heym du potin comme une voie pour communiquer la vérité subversive dans les régimes autoritaires, je cite la recherche historique systématique de Robert Darnton au sujet des voies diverses pour communiquer les nouvelles de Paris au dix-huitième siècle (Darnton, 2000. In The King David Report (1972, Stefan Heym (1913-2001 offers a favorable view of gossip, notwithstanding biblical censuring of that activity (e.g. Proverb 11:13. Heym's satirical re-telling of the biblical story focuses on the character of Ethan, a writer-historian appointed by King Solomon to compose an official report on the life and rise to power of King David. At one point Ethan's two sons, Shem and Sheleph, come back from the market, telling Ethan of some "juicy" rumors they heard there. These rumors, while using some exaggerations and added embellishments, nevertheless provide insights into the political situation much more faithful to the truth than the fabrications of official spokespersons. To substantiate Heym's literary portrayal of gossip as a channel for communicating subversive truth in authoritarian regimes, I cite Robert Darnton

  10. Quantifying the impact of using Coronary Artery Calcium Score for risk categorization instead of Framingham Score or European Heart SCORE in lipid lowering algorithms in a Middle Eastern population.

    Science.gov (United States)

    Isma'eel, Hussain A; Almedawar, Mohamad M; Harbieh, Bernard; Alajaji, Wissam; Al-Shaar, Laila; Hourani, Mukbil; El-Merhi, Fadi; Alam, Samir; Abchee, Antoine

    2015-10-01

    The use of the Coronary Artery Calcium Score (CACS) for risk categorization instead of the Framingham Risk Score (FRS) or European Heart SCORE (EHS) to improve classification of individuals is well documented. However, the impact of reclassifying individuals using CACS on initiating lipid lowering therapy is not well understood. We aimed to determine the percentage of individuals not requiring lipid lowering therapy as per the FRS and EHS models but are found to require it using CACS and vice versa; and to determine the level of agreement between CACS, FRS and EHS based models. Data was collected for 500 consecutive patients who had already undergone CACS. However, only 242 patients met the inclusion criteria and were included in the analysis. Risk stratification comparisons were conducted according to CACS, FRS, and EHS, and the agreement (Kappa) between them was calculated. In accordance with the models, 79.7% to 81.5% of high-risk individuals were down-classified by CACS, while 6.8% to 7.6% of individuals at intermediate risk were up-classified to high risk by CACS, with slight to moderate agreement. Moreover, CACS recommended treatment to 5.7% and 5.8% of subjects untreated according to European and Canadian guidelines, respectively; whereas 75.2% to 81.2% of those treated in line with the guidelines would not be treated based on CACS. In this simulation, using CACS for risk categorization warrants lipid lowering treatment for 5-6% and spares 70-80% from treatment in accordance with the guidelines. Current strong evidence from double randomized clinical trials is in support of guideline recommendations. Our results call for a prospective trial to explore the benefits/risks of a CACS-based approach before any recommendations can be made.

  11. Concordance with World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines for cancer prevention and obesity-related cancer risk in the Framingham Offspring cohort (1991-2008).

    Science.gov (United States)

    Makarem, Nour; Lin, Yong; Bandera, Elisa V; Jacques, Paul F; Parekh, Niyati

    2015-02-01

    This prospective cohort study evaluates associations between healthful behaviors consistent with WCRF/AICR cancer prevention guidelines and obesity-related cancer risk, as a third of cancers are estimated to be preventable. The study sample consisted of adults from the Framingham Offspring cohort (n = 2,983). From 1991 to 2008, 480 incident doctor-diagnosed obesity-related cancers were identified. Data on diet, measured by a food frequency questionnaire, anthropometric measures, and self-reported physical activity, collected in 1991 was used to construct a 7-component score based on recommendations for body fatness, physical activity, foods that promote weight gain, plant foods, animal foods, alcohol, and food preservation, processing, and preparation. Multivariable Cox regression models were used to estimate associations between the computed score, its components, and subcomponents in relation to obesity-related cancer risk. The overall score was not associated with obesity-related cancer risk after adjusting for age, sex, smoking, energy, and preexisting conditions (HR 0.94, 95 % CI 0.86-1.02). When score components were evaluated separately, for every unit increment in the alcohol score, there was 29 % lower risk of obesity-related cancers (HR 0.71, 95 % CI 0.51-0.99) and 49-71 % reduced risk of breast, prostate, and colorectal cancers. Every unit increment in the subcomponent score for non-starchy plant foods (fruits, vegetables, and legumes) among participants who consume starchy vegetables was associated with 66 % reduced risk of colorectal cancer (HR 0.44, 95 % CI 0.22-0.88). Lower alcohol consumption and a plant-based diet consistent with the cancer prevention guidelines were associated with reduced risk of obesity-related cancers in this population.

  12. Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study123

    Science.gov (United States)

    Farina, Emily K; Kiel, Douglas P; Roubenoff, Ronenn; Schaefer, Ernst J; Cupples, L Adrienne

    2011-01-01

    Background: Polyunsaturated fatty acids and fish may influence bone health. Objective: We aimed to examine associations between dietary polyunsaturated fatty acid and fish intakes and hip bone mineral density (BMD) at baseline (1988–1989; n = 854) and changes 4 y later in adults (n = 623) with a mean age of 75 y in the Framingham Osteoporosis Study. Design: BMD measures were regressed on energy-adjusted quartiles of fatty acid intakes [n−3 (omega-3): α-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and EPA+ DHA; n−6 (omega-6): linoleic acid (LA) and arachidonic acid (AA); and n−6:n−3 ratio] and on categorized fish intakes, with adjustment for covariates. Effect modification by EPA+DHA intake was tested for n−6 exposures. Results: High intakes (≥3 servings/wk) of fish relative to lower intakes were associated with maintenance of femoral neck BMD (FN-BMD) in men (dark fish + tuna, dark fish, and tuna) and in women (dark fish) (P < 0.05). Significant interactions between AA and EPA+DHA intakes were observed cross-sectionally in women and longitudinally in men. In women with EPA+DHA intakes at or above the median, those with the highest AA intakes had a higher mean baseline FN-BMD than did those with the lowest intakes (quartile 4 compared with quartile 1: P = 0.03, P for trend = 0.02). In men with the lowest EPA+DHA intakes (quartile 1), those with the highest intakes of AA (quartile 4) lost more FN-BMD than did men with the lowest intakes of AA (quartile 1; P = 0.04). LA intake tended to be associated with FN-BMD loss in women (P for trend < 0.06). Conclusions: Fish consumption may protect against bone loss. The protective effects of a high AA intake may be dependent on the amount of EPA+DHA intake. PMID:21367955

  13. OS LIMITES DO ‘DESENVOLVIMENTO LOCAL’ E AS POSSIBILIDADES ABERTAS PELA ABORDAGEM DIALÉTICA PROPOSTA POR DAVID HARVEY PARA COMPREENDER UMA REGIÃO

    Directory of Open Access Journals (Sweden)

    Rogério Faé

    2012-12-01

    Full Text Available O objetivo deste artigo é fundamentar a escolha pela perspectiva teórica do materialismo histórico-geográfico, desenvolvida pelo geógrafo David Harvey para compreender uma região. Para tanto, apresentamos e discutimos também os referenciais predominantes nas análises sobre regiões, com o intuito de demonstrar os limites desses referenciais e as possibilidades abertas pela perspectiva de Harvey. Assim, apresentamos alguns dos principais conceitos que têm orientado as ações de governos dos mais diversos matizes; a abordagem de David Harvey bem como seus pressupostos teóricos e históricos; e uma análise comparativa em que demonstramos as limitações dos referenciais predominantes e as possibilidades da perspectiva do último autor. Ao final, conclui-se que o materialismo histórico-geográfico permite compreender que as dinâmicas sociais e econômicas de uma região se caracterizam em processos conflituosos e contraditórios e resultam em uma configuração regional específica e transitória.

  14. O futuro do jornalismo e a mudança na cultura profissional a partir da visão etnográfica de David M. Ryfe

    Directory of Open Access Journals (Sweden)

    Ana Carolina Kalume Maranhão

    2014-06-01

    Full Text Available Tratar do futuro do jornalismo e dos fatores que levaram jornalistas a não reagirem diante da mudança é o objetivo do trabalho etnográfico empreendido por David M. Ryfe em Can Journalism Survive? An Inside Look At American Newsrooms. Ao longo de 220 páginas, o autor aborda os fatores pelos quais jornais norte-americanos não conseguiram lidar com as alterações causadas pelo desenvolvimento tecnológico. A obra apresenta uma reflexão sobre os significados da prática profissional do jornalismo, propondo um enredo que aponta o modo como a industria dos jornais e os jornalistas atuam na contemporaneidade.

  15. From David Walker to President Obama: Tropes of the Founding Fathers in African American Discourses of Democracy, or The Legacy of Ishmael

    Directory of Open Access Journals (Sweden)

    Elizabeth J. West

    2012-01-01

    Full Text Available More than a century after the Emancipation Proclamation, in a society that still others blackness, we continue to hold to the mythical humanizing power of literacy. In our own time this has been poignantly evinced in the public reception of the current President of the United States, Barack Obama. He has been internationally hailed for his written and oral eloquence, and many Americans expected that Obama’s evident intellectual prowess would reverse prevailing stereotypes of black inferiority. Obama’s rhetorical success is rooted in the longstanding literary practice of invoking the mythical founding fathers to validate text and subject. In this regard, David Walker’s Appeal (1829 represents the emergence of a long tradition of black voices invoking America’s most sacred patriarchs and their rhetoric of Americanness.

  16. Towards a new vision of economic policy: Discussion around the new paradigm proposed by David Romer in “Keynesian macroeconomics without the LM curve”

    Directory of Open Access Journals (Sweden)

    Marco Leonardo Penagos Rozo

    2013-01-01

    Full Text Available New Keynesians (NK refer to an advanced posture compared to the traditional paradigm of the IS-LM equilibrium, which, as a tool, satisfied economic policy explanations for the moment. The model had critics like be considered not to have microeconomic foundations, among others. Perhaps at the times presented: Keynes, in 1936, with the General Theory, Hicks, in 1937, with Mr. Keynes and the classics; Samuelson in 1948 and subsequent years, with his work Economy, it provided important elements in the balance. However, a new approach was needed for the Twenty-First Century, and it is the one proposed by David Romer. The purpose of this article is to make an initial review for understanding how some aspects of economic policy are linked as elements of economic growth.

  17. Slow reception and under-citedness in climate change research: A case study of Charles David Keeling, discoverer of the risk of global warming.

    Science.gov (United States)

    Marx, Werner; Haunschild, Robin; French, Bernie; Bornmann, Lutz

    2017-01-01

    The Keeling curve has become a chemical landmark, whereas the papers by Charles David Keeling about the underlying carbon dioxide measurements are not cited as often as can be expected against the backdrop of his final approval. In this bibliometric study, we analyze Keeling's papers as a case study for under-citedness of climate change publications. Three possible reasons for the under-citedness of Keeling's papers are discussed: (1) The discourse on global cooling at the starting time of Keeling's measurement program, (2) the underestimation of what is often seen as "routine science", and (3) the amount of implicit/informal citations at the expense of explicit/formal (reference-based) citations. Those reasons may have contributed more or less to the slow reception and the under-citedness of Keeling's seminal works.

  18. Connla's well: An exploration of similar elements of ancient Celtic perspectives and David Bohm's theories in quantum physics from a Jungian perspective

    Science.gov (United States)

    Maciel, Duan

    This dissertation addresses the common elements between ancient Celtic mystical doctrines and philosophy and David Bohm's unique theories in quantum physics through a Jungian lens, using research based in dialogical hermeneutics. The premise of this dissertation is that psi, or the probability wave function of quantum physics, and its world of potentia are the same entities as Jung's objective psyche (or collective unconscious) and its domain, the unus mundus. In addition, the study explores the remarkable similarity between the ancient Celts' Otherworld, quantum physics' world of potentia, and Jung's unus mundus. These similarities argue for an in-depth Jungian analysis of this important but largely neglected mythology. The study explores the supposition, based partially on physicist David Bohm's theories of the implicate and explicate orders, that the above world of potentia intertwines with our three-dimensional world in a reciprocal creativity, designed to enhance both worlds. The study further advocates a greater emphasis on the creative arts therapies in the therapeutic situation, based on the above reciprocity. It is argued that this emphasis on creativity in the temenos may activate a profound "quantum leap" of insight in the analysand, most likely due to the reciprocity in which the objective psyche responds uniquely to the particular and individual creativity offered in order to heal the personal psyche. As we creatively access the objective psyche, that entity responds in kind, giving us new understanding and allowing us to change our attitudes and to further individuation, which in turn enhances the objective psyche. In addition, a psyche of reality is postulated in which Jung's concept of the objective psyche is expanded from the collective unconscious of humankind to a collective unconscious of All That Is, reflecting the findings in quantum physics that our universe is self-aware, organic, and holistic rather than mechanical and fragmented.

  19. Predicting Risk of Cognitive Decline in Very Old Adults Using Three Models: The Framingham Stroke Risk Profile; the Cardiovascular Risk Factors, Aging, and Dementia Model; and Oxi-Inflammatory Biomarkers.

    Science.gov (United States)

    Harrison, Stephanie L; de Craen, Anton J M; Kerse, Ngaire; Teh, Ruth; Granic, Antoneta; Davies, Karen; Wesnes, Keith A; den Elzen, Wendy P J; Gussekloo, Jacobijn; Kirkwood, Thomas B L; Robinson, Louise; Jagger, Carol; Siervo, Mario; Stephan, Blossom C M

    2017-02-01

    To examine the Framingham Stroke Risk Profile (FSRP); the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score, and oxi-inflammatory load (cumulative risk score of three blood biomarkers-homocysteine, interleukin-6, C-reactive protein) for associations with cognitive decline using three cohort studies of very old adults and to examine whether incorporating these biomarkers with the risk scores can affect the association with cognitive decline. Three longitudinal, population-based cohort studies. Newcastle-upon-Tyne, United Kingdom; Leiden, the Netherlands; and Lakes and Bay of Plenty District Health Board areas, New Zealand. Newcastle 85+ Study participants (n = 616), Leiden 85-plus Study participants (n = 444), and Life and Living in Advanced Age, a Cohort Study in New Zealand (LiLACS NZ Study) participants (n = 396). FSRP, CAIDE risk score, oxi-inflammatory load, FSRP incorporating oxi-inflammatory load, and CAIDE risk score incorporating oxi-inflammatory load. Oxi-inflammatory load could be calculated only in the Newcastle 85+ and the Leiden 85-plus studies. Measures of global cognitive function were available for all three data sets. Domain-specific measures were available for the Newcastle 85+ and the Leiden 85-plus studies. Meta-analysis of pooled results showed greater risk of incident global cognitive impairment with higher FSRP (hazard ratio (HR) = 1.46, 95% confidence interval (CI) = 1.08-1.98), CAIDE (HR = 1.53, 95% CI = 1.09-2.14), and oxi-inflammatory load (HR = 1.73, 95% CI = 1.04-2.88) scores. Adding oxi-inflammatory load to the risk scores increased the risk of cognitive impairment for the FSRP (HR = 1.65, 95% CI = 1.17-2.33) and the CAIDE model (HR = 1.93, 95% CI = 1.39-2.67). Adding oxi-inflammatory load to cardiovascular risk scores may be useful for determining risk of cognitive impairment in very old adults. © 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.

  20. Differential incremental value of ultrasound carotid intima-media thickness, carotid plaque, and cardiac calcium to predict angiographic coronary artery disease across Framingham risk score strata in the APRES multicentre study.

    Science.gov (United States)

    Gaibazzi, Nicola; Rigo, Fausto; Facchetti, Rita; Carerj, Scipione; Giannattasio, Cristina; Moreo, Antonella; Mureddu, Gian Francesco; Salvetti, Massimo; Grolla, Elisabetta; Faden, Giacomo; Cesana, Francesca; Faggiano, Pompilio

    2016-09-01

    According to recent data, more accurate selection of patients undergoing coronary angiography for suspected coronary artery disease (CAD) is needed. From the Active PREvention Study multicentre prospective study, we further analyse whether carotid intima-media thickness (cIMT), carotid plaques (cPL), and echocardiographic cardiac calcium score (eCS) have incremental discriminatory and reclassification predictive value for CAD over clinical risk score in subjects undergoing coronary angiography, specifically depending on their low, intermediate, or high class of clinical risk. In eight centres, 445 subjects without history of prior CAD but with chest pain of recent onset and/or a positive/inconclusive stress test for ischaemia prospectively underwent clinically indicated elective coronary angiography after cardiac and carotid ultrasound assessments with measurements of cIMT, cPL, and eCS. The study population was divided into subjects at low (10%), intermediate (10-20%), and high (>20%) Framingham risk score (FRS). Ultrasound parameters were tested for their incremental value to predict CAD over FRS, in each pre-test risk category. No significant difference could be appreciated between the discrimination value of FRS and Diagnostic Imaging for Coronary Artery Disease score for the presence of CAD. eCS or cPL demonstrated significant incremental prediction over FRS, consistently in the three FRS categories (P risk subjects, in whom cPL was apparently not incremental over FRS, and eCS was only of borderline significance for better discrimination. Ultrasound eCS and cPL assessments were significant predictors of angiographic CAD in patients without prior CAD but with signs or symptoms suspect for CAD, independently and incrementally to FRS, across all pre-test risk probability strata, although in high-risk subjects, only eCS maintained an incremental value. The use of cIMT was not significantly incrementally useful in any FRS risk category. Published on behalf of the

  1. The genesis of an ‘interesting’ and important social and environmental accounting conversation: Celebrating the contribution of professor David Owen to social and environmental accounting and auditing (SEAA) research and practice

    NARCIS (Netherlands)

    O'Dwyer, B.

    2011-01-01

    This paper reflects on the nature of ‘interesting’ research in the context of the contributions Professor David Owen has made to the social and environmental accounting and auditing (SEAA) research field over his academic career. The paper reviews some of Professor Owen's key research themes and

  2. NCEP ATP III dan Framingham score

    OpenAIRE

    Hasan, Refli; Fahila, Reny

    2016-01-01

    Laporan ini merupakan Program Pendidikan Kolesterol National yang diperbaharui yaitu pedoman klinis untuk melakukan pengujian kolesterol dan manajemen. ATP III dibuat berdasarkan bukti dan laporan ekstensif yang akan menjadi referensi dan rekomendasi ilmiah. Laporan ATP III dapat dijadikan pedoman untuk pemberian terapi penurun kolesterol yang intensif dalam praktek. Pedoman ini hanya sebagai informasi , tidak dapat mempengaruhi secara mutlak dalam penilaian klinis dokter yang akhirnya menent...

  3. David valve-sparing aortic root replacement: equivalent mid-term outcome for different valve types with or without connective tissue disorder.

    Science.gov (United States)

    Kvitting, John-Peder Escobar; Kari, Fabian A; Fischbein, Michael P; Liang, David H; Beraud, Anne-Sophie; Stephens, Elizabeth H; Mitchell, R Scott; Miller, D Craig

    2013-01-01

    Although implicitly accepted by many that the durability of valve-sparing aortic root replacement in patients with bicuspid aortic valve disease and connective tissue disorders will be inferior, this hypothesis has not been rigorously investigated. From 1993 to 2009, 233 patients (27% bicuspid aortic valve, 40% Marfan syndrome) underwent Tirone David valve-sparing aortic root replacement. Follow-up averaged 4.7 ± 3.3 years (1102 patient-years). Freedom from adverse outcomes was determined using log-rank calculations. Survival at 5 and 10 years was 98.7% ± 0.7% and 93.5% ± 5.1%, respectively. Freedom from reoperation (all causes) on the aortic root was 92.2% ± 3.6% at 10 years; 3 reoperations were aortic valve replacement owing to structural valve deterioration. Freedom from structural valve deterioration at 10 years was 96.1% ± 2.1%. No significant differences were found in survival (P = .805, P = .793, respectively), reoperation (P = .179, P = .973, respectively), structural valve deterioration (P = .639, P = .982, respectively), or any other functional or clinical endpoints when patients were stratified by valve type (tricuspid aortic valve vs bicuspid aortic valve) or associated connective tissue disorder. At the latest echocardiographic follow-up (95% complete), 202 patients (94.8%) had none or trace aortic regurgitation, 10 (4.7%) mild, 0 had moderate to severe, and 1 (0.5%) had severe aortic regurgitation. Freedom from greater than 2+ aortic regurgitation at 10 years was 95.3% ± 2.5%. Six patients sustained acute type B aortic dissection (freedom at 10 years, 90.4% ± 5.0%). Tirone David reimplantation valve-sparing aortic root replacement in carefully selected young patients was associated with excellent clinical and echocardiographic outcome in patients with either a tricuspid aortic valve or bicuspid aortic valve. No demonstrable adverse influence was found for Marfan syndrome or connective tissue disorder on durability, clinical outcome

  4. "Mina olin siin", võib vastu hambaid saada / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Noortefilmi "Mina olin siin" võtetel. Filmi aluseks on Sass Henno romaan "Mina olin siin. Esimene arest", stsenaariumi kirjutas Ilmar Raag, lavastab Rene Vilbre, operaator on Mait Mäekivi, peaosas Rasmus Kaljujärv, produtsendiks Riina Sildos

  5. Kas me sellist eesti keelt tahtsime? / Anu Lamp ; interv. Andres Keil

    Index Scriptorium Estoniae

    Lamp, Anu, 1958-

    2006-01-01

    24. märtsil esietendus teatris NO99 lavakunstikooli 22. lennu viimane diplomilavastus "Keeleuuenduse lõpmatu kurv". Lavastaja Anu Lamp räägib eesti keelest ja sellest, kuidas materjal Johannes Aaviku keeleuuendusest lavale jõudis

  6. Viljandi kultuuriakadeemia tudengid lajatasid kolme tükiga / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Janusz Glowacki "Fortinbras jõi end täis" Viljandi Kultuuriakadeemia teatrikunsti eriala 6. lennu esituses, lavastaja Kalju Komissarov ja Sven Heiberg ; Ott Aardami "Börs ja börsitar" ja Henrik Ibseni "Nora/Maja", lavastaja Helen Rekkor

  7. Ela ja sära - setu pitsist ekvaatorireisini / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2004-01-01

    Eesti Kultuurkapitali "Ela ja sära" stipendiumi laureaadid kirjanik Eeva Park, kunstnik Kai Kaljo, sporditeadlane Joe Noormets, näitleja Kersti Kreismann, pitsikunstnik Ulve Kangro, režissöör Marko Raat, disainer Tarmo Luisk ja helilooja Urmas Sisask oma loomingulistest plaanidest

  8. Review: Michael Kerres & Reinhard Keil-Slawik (Hrsg.) (2005). Hochschulen im digitalen Zeitalter: Innovationspotenziale und Strukturwandel

    OpenAIRE

    Hoidn, Sabine

    2008-01-01

    In dem vorliegenden Kongressband setzen sich fünfunddreißig internationale Expertinnen und Experten aus Wissenschaft und Praxis mit Möglichkeiten und Rahmenbedingungen des Einsatzes von Informations- und Kommunikationstechnologien in Hochschulen auseinander. Die Beiträge adressieren aktuelle und zukünftige Herausforderungen, denen sich Hochschulen zu stellen haben, und präsentieren einen bunten Strauß an (bisher) erfolgreichen Projekten und Praxiserfahrungen. Infolge knapper werdender Ressour...

  9. Kinkaleri : teater peab tekitama küsimuse, mitte andma vastuse / Marco Mazzoni ; interv. Andres Keil

    Index Scriptorium Estoniae

    Mazzoni, Marco

    2008-01-01

    1995. a. Itaalias asutatud kuuest kunstnikust - Matteo Bambi, Luca Camilletti, Massimo Conti, Marco Mazzoni, Gina Monaco ja Cristina Rizzo - koosnevast eksperimentaalteatrist Kinkaleri ja Kanuti Gildi saalis 7. ja 8. nov. esiettekandele tulevast lavastusest "Yes, Sir!"

  10. Elmo Nüganeni "Laulatus" võitis Poolas neli preemiat / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2005-01-01

    E. Nüganeni Poolas, Toruni teatris valminud lavastus - W. Gombrowiczi "Laulatus"- pälvis Opole festivalil "Poola klassika" neli preemiat : Nüganen sai lavastaja-, A. Sekula kunstnikupreemia ja lisaks kaks näitlejapreemiat - V. Bogdanasele ja S. Maciejewskile

  11. Piiteri "Uue draama" märgistik hakkab selguma / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2004-01-01

    Peterburi teatrifestivalist "Novaja drama" (Uus draama), kus M. Karusoo lavastus "Eestisse sündinud" tekitas furoori. Pikemalt peatutakse ka K. Kostenko "Klaustrofoobial" - Koljada-Teatri ja Teatroni koostööl, samuti gruusia autori L. Bugadze näidendi "Šokeeritud Tatjana" lavastusel.

  12. Talveöös kõnnivad unenäod / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2004-01-01

    Kolmanda rahvusvahelise teatrifestivali "Talveöö unenägu" külalislavastustest : Gesher teatri esituses ja J. Arie lavastuses "Ori", Valgevene Akad. Rahvusteatri esituses ja P. Adamtshikovi lavastuses "Kirsiaed" (pealkirjaga "S.V."), Rootsi Backa teatri esituses E. Östergreni "Girlpower" M. Stenbergi lavastuses ning Soome KOM-teatri esituses R. Lundáni "Tarbetud inimesed"

  13. Märts - teatrikuu, nädalavahetusel viis esietendust / Tiiu Laks, Andres Keil

    Index Scriptorium Estoniae

    Laks, Tiiu, 1984-

    2008-01-01

    Nädalavahetuse viiest esietendusest : Teatris NO99 William Shakespeare'i "Perikles" Tiit Ojasoo lavastuses, Endlas "Pommimäng" Joseph Helleri näitemängu "Me pommitasime New Havenit" järgi Madis Kalmeti lavastuses, Tallinna Linnateatris Jón Atli Jónassoni "Murdlainetus" Jaanus Rohumaa lavastuses, Eesti Draamateatris Enn Vetemaa-Erki Aule "Sigma TAU C705" Merle Karusoo lavastuses, Rakvere Teatris Urmas Lennuki kirjutatud ja lavastatud "Päeva lõpus"

  14. Baltoscandal on lõppenud, uued mõtted on saadud / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2006-01-01

    Eesti teater oli Baltoscandalil koondatud olematu teatri mõiste alla. Andres Noormetsa "Reunioon", Mart Kangro ja Ansambel U "Mäng", Marco Laimre "Vangistus", Asko Künnapi "Säälpool jõge", Anders Härmi "Cooking and Shitting", Sven Kuntu "Miks Eesti mehed ei tantsi?", Linnar Priimäe "Inimese lõhn"

  15. Sinema-Resim İlişkisi Bağlamında David Lynch ve ‘Silgikafa’ Filmi

    OpenAIRE

    Güngör, Arif Can

    2016-01-01

    Sinema geçmişten günümüze kadar tüm sanat dallarından yararlanmış, özellikle görsel bir sanat olan resim sanatıyla estetik açıdan çok yakın bir ilişki içinde bulunmuştur. Sinemanın resim sanatından yararlanmasında en önemli etken yönetmenin bu sanatla kurduğu bağ olmuş, özellikle ressam yönetmenler estetik anlamda resmin olanaklarından yararlanarak filmlerine plastik bir değer katmışlardır. Bu makalenin amacı sinema sanatı ile resim sanatı arasındaki ilişkiyi ressam yönetmen David Lynch ve on...

  16. From precocious fame to mature obscurity: David Walker (1837-1917) MD, LRCSI, surgeon and naturalist to the Fox Arctic Expedition of 1857-59.

    Science.gov (United States)

    Froggatt, Peter; Walker, Brian M

    2012-11-01

    The Belfast-born David Walker was the 19-year-old surgeon and naturalist on the epic Fox Arctic Expedition (1857-59) that established the fate of Sir John Franklin's unsuccessful (1845) search for the North-West Passage. On return the crew were fêted as heroes and decorated, and shared in a £5000 government bounty: Walker was also received by the Queen and (in Ireland) by the Lord Lieutenant, was honoured by the principal British and Irish natural history societies and his portrait was exhibited in the National Portrait Gallery, London. This paper describes his adventurous life, including the Fox Expedition, which from 1862 was spent abroad and included time in the Cariboo gold fields, service in the United States Army, practice in a notorious Californian frontier town and, in later life, the comparative quiet of general and occupational medical practice in Portland, Oregon. Once a household name, his death went unrecorded in the British and Irish medical and lay press.

  17. In response to David Greenwood's `Place mobility and faculty life: mindfulness through change' through the lens of science teacher education programs

    Science.gov (United States)

    Nyaema, Mary K.

    2017-06-01

    In writing this review, I draw on the experience of David Greenwood (Cult Stud Sci Educ 10:5-16, 2015) whose ethnographic study sheds light on his growth as a faculty member who has taught in various settings that are quite different from the culture that he grew up with. I extend his thoughts on ecological mindfulness to encompass a culturally aware method of teaching based on place sensitized more to the needs of science teacher preparation programs. The methods used in writing the review included literature searches for articles that incorporate ecological mindfulness and culturally responsive teaching in science teacher preparation programs and reflected ideas voiced in Greenwood's article. Although he seems that he is primarily addressing other faculty members, his experiences can be used as lifelong lessons for preservice teachers entering a primarily homogeneous workforce expected to teach an increasingly diverse student population. His humor, use of Haiku, poetry and mindfulness as a way of becoming one with a culture that he is not accustomed has many lessons that prove useful in training more culturally responsive teachers. In light of an increasingly diverse US student population versus a stagnantly homogeneous teaching workforce, his reflective practice will prove useful to teachers who are expected to teach students with cultures different from their own.

  18. The University of Chicago contribution to the treatment of gastroesophageal reflux disease and its complications: a tribute to David B. Skinner 1935-2003.

    Science.gov (United States)

    Greene, Christina L; Worrell, Stephanie G; Patti, Marco G; DeMeester, Tom R

    2015-03-01

    To highlight the contributions from the University of Chicago under the leadership of Dr David B. Skinner to the understanding of gastroesophageal reflux disease (GERD) and its complications. The invention of the esophagoscope confirmed that GERD was a premorbid condition. The medical world was divided between those who believed in a morphological lower esophageal sphincter (LES) and those who did not. Those who did not believe attempted to rearrange the anatomy of the foregut organs to stop reflux with minimal success. The discovery of the LES focused attention on the sphincter as the main deterrent to reflux and the hope that measurement of a low LES pressure would mark the presence of GERD. This turned out not to be so. In July 1973, with this history of confusion, Dr Skinner at the age of 36 assumed the chair of surgery at the University of Chicago. The publications of the University of Chicago's esophageal group were collected from private and public (PubMed) databases, reviewed, and seminal contributions selected. Twenty-four-hour esophageal pH monitoring led to the understanding of the LES, its contribution to GERD, and the complication of Barrett's esophagus. The relationship of Barrett's to adenocarcinoma was clarified. The rising incidence of esophageal adenocarcinoma led to contributions in the staging of esophageal cancer and its treatment with an en bloc resection. Ten years after the death of Dr Skinner, we can appreciate the monumental contributions to benign and malignant esophageal disease under his leadership.

  19. Re-membering the Bard : David Greig’s and Liz Lochhead’sRe-visionary Reminiscences of “The Tempest”

    Directory of Open Access Journals (Sweden)

    Maria Elena Capitani

    2017-12-01

    Full Text Available The Tempest (1611 is one of those Shakespearean texts which have been adopted and adapted most frequently. This article explores two early Nineties appropriations of the Bard’s romance, that is David Greig’s unpublished monologue A Savage Reminiscence or (How to Snare the Nimble Marmoset, first performed in 1991, and Liz Lochhead’s The Magic Island, a rewriting of The Tempest for seven- to eleven-year-olds, first staged in 1993. Even if they differ from a variety of points of view, both Scottish Tempests retell the Shakespearean narrative through the lens of memory. In Greig’s appropriation, after being left alone on the island, a guilty Caliban recollects some past events – in particular his rape of Miranda – from his own marginalised perspective. Similarly, Lochhead’s The Magic Island, which adapts Shakespeare’s play to the needs and taste of a young audience by focusing on the theme of friendship, reconstructs the story retrospectively through the eyes of Prospero’s daughter. Through a web of intertextual references interwoven with contemporary echoes, Greig and Lochhead re-member and dismember their source problematizing any unimaginative subscription to the Shakespearean canon.

  20. Stepping backwards with disability humor? The case of NY Gov. David Paterson’s representation on ‘Saturday Night Live’

    Directory of Open Access Journals (Sweden)

    Beth Haller

    2014-01-01

    Full Text Available In the modern era, discerning TV viewers know the shows that trade in cheap laughs by making fun of people with disabilities are not tapping into much creativity. So it was a surprise in 2008 when the highly regarded comedy show Saturday Night Live (SNL stooped to that level by ridiculing the blind governor of New York, David Paterson, in a series of sketches lasting two years. This article analyzes the way humor narratives about a high-profile blind politician on television, like those depicted in the SNL skits, may have influenced larger cultural themes about blindness. Because the East Coast news media reported on the SNL skits every time an episode aired, this project undertook a textual analysis of all aspects of the controversy including the content of the SNL skits, the repeated responses from Gov. Paterson and the blindness community, and the news media framing of the SNL-Paterson skit story. This analysis examines the intertextuality of the event, revealing that the blindness community had a very different reading of the SNL skits, due to concerns about continuing media narratives that devalue and stereotype them.   Keywords: blindness, disability humor, TV comedy shows, skit comedy, politicians

  1. "Nuestro lugar en el mundo está fuera del mundo pero cerca de ti". Una aproximación a Bocado, de David Preiss

    Directory of Open Access Journals (Sweden)

    Javier Bello

    2013-05-01

    Full Text Available Resulta clave en Bocado, el más reciente poemario de David Preiss, el verso que reza"la muerte prepara a la muerte" (Preiss 11. Se trata de una aporía que esconde, pese a suapariencia circular, cerrada, un desarrollo en el pensamiento y un desplazamiento que no seve aplazado, paradoja que los textos del libro articulan en múltiples instancias, encarnadaen diversas formas, y que subyace a la totalidad del conjunto. En el imaginario de Preiss,la muerte, el fin de la vida, se reproduce, persiste más allá de toda constatación, ya nosolo en el sentido en que, en el contexto de la Shoá, la memoria y el orden simbólico yreproductivo son experimentados como un abuso, una asfixiante imposición divina para elsujeto testigo -como intenté observar en un trabajo anterior (Bello 2012 sobre Señor delvértigo, el primer libro del autor (Preiss 1992, 1994 -, sino en un sentido anterior, quepuede llegar a resignificar, desde aquí, aunque sea parcialmente, las contradicciones dela subjetividad y la masculinidad enfrentadas al mandato del testimonio. La persistenciade la muerte trata aquí de la condición inseparable de vida y muerte, dos fuerzas queen el inconsciente de la escritura aparecen complementarias, pero que son leídas comoopuestas por la conciencia objetual y referencial.

  2. Scholar – Fictionist – Memoirist: David Lodge’s Documentary (Self-Biography in Quite a Good Time to be Born: 1935–1975

    Directory of Open Access Journals (Sweden)

    Kusek Robert

    2016-03-01

    Full Text Available Over the last decade or so, David Lodge has become not only a reader but also an avid practitioner of “fact-based writing” - be it the biographical novel (The Master of 2004 and A Man of Parts 2011, the autobiographical novel (Deaf Sentence of 2008, the biographical essay (Lives in Writing of 2014 and - finally - a proper autobiography (Quite a Good Time to Be Born of 2015. The aim of this paper is to analyse Lodge’s recent turn to life narratives and, in particular, his autobiographical story of 2015; and, consequently, to address the following questions: Does Lodge’s memoir offer “an experiment in autobiography” (to quote H.G. Wells, one of Lodge’s favourites, or remain a conventional life story immune to the tenets of contemporary life writing? Is it the work of a (self- historian, or a novelist? Does it belong to the “regime of truth,” or is it the product of memory? Finally, is it, indeed, a memoir (as its subtitle claims, or a specimen of self-biography? The paper will show special interest in the work’s generic characteristics and will offer an attempt to locate Quite a Good Time to Be Born on the map of contemporary life writing practices.

  3. “A Whole Alternative Universe”: Language and Space in David Malouf’s “The Only Speaker of His Tongue”

    Directory of Open Access Journals (Sweden)

    Deborah Scheidt

    2016-06-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2016v69n2p33 By displacing Aboriginal communities, interfering with their migratorial routes and sacred sites and forcing them into sedentary practices, European colonialism disrupted the closely-knit links between people, space and language that had characterised life in Australia for 40,000 years prior to the arrival of the British. In linguistic terms that meant the disappearance of hundreds of languages, the devitalising of traditions that had been based mainly on orality and, ultimately, the silencing of thousands of voices. In the short story “The Only Speaker of His Tongue”, David Malouf addresses the threat that the loss of a language poses to cultural diversity. The plot consists of a skilful incursion into the mind of a Nordic lexicographer as he meets the object of his curiosity:  the last speaker of a certain Australian language. Although the encounter is fictitious and the story is extremely concise, it reaches much beyond its fictional status by, both directly and indirectly, raising issues related to the past and present treatment that Australia has dedicated to its Aboriginal peoples, to the complexities of the field of salvage linguistics and to the functions of language itself.

  4. A Educação Médica entre mapas e âncoras: a aprendizagem significativa de David Ausubel, em busca da Arca Perdida

    Directory of Open Access Journals (Sweden)

    Andréia Patrícia Gomes

    Full Text Available O processo de aprendizagem tem motivado, desde a Antigüidade, intensos debates. Dentre as diferentes teorias propostas tem ganho relevância, nos séculos XX e XXI, a concepção cognitivista de David Ausubel, na qual se assume que os mecanismos do aprender são mais eficientes em situações nas quais o estudante consegue, utilizando conhecimentos prévios, agregar e incorporar significado aos novos conteúdos, evitando-se, assim, que esse conhecimento recém-incorporado seja armazenado, por meio de associações ineptas, à estrutura cognitiva. No âmbito da educação médica, diante das imperiosas mudanças necessárias para a formação de um profissional que aprenda a aprender, a aprendizagem significativa permite uma genuína contextualização dos conhecimentos necessários à prática médica, facultando, portanto, um aprendizado mais efetivo e permitindo a atuação em um contexto complexo e interdisciplinar. Em conformidade com o exposto, o presente manuscrito objetiva apresentar a teoria da aprendizagem significativa, discutindo elementos da incorporação deste conceito à educação médica.

  5. Long-term outcome after the original and simple modified technique of valve-sparing aortic root reimplantation in Marfan-based population, David V University of Tokyo modification.

    Science.gov (United States)

    Ando, Masahiko; Yamauchi, Haruo; Morota, Tetsuro; Taketani, Tsuyoshi; Shimada, Shogo; Nawata, Kan; Umeki, Akihide; Ono, Minoru

    2016-01-01

    In valve-sparing aortic root replacement (VSARR), how to reproduce Valsalva sinus has been an issue. In the original David V procedure, they put plication stitches at sinotubular junction level, although the reefing effect is limited and distal graft remains larger than native. Other modified techniques are two-grafts technique and ready-made Valsalva graft. However, the former needs graft-graft anastomosis and may not be cost-effective, while in the latter, the shape of sinus is fixed and minor adjustment is difficult. David V University of Tokyo modification (David V-UT) is our original solution to that, creating pseudosinus with one straight graft by longitudinal size-reduction running sutures above each pseudosinus. The purpose of the present study is to investigate long-term outcome of David V-UT. We analyzed 59 David V-UT patients from February 2004 to February 2013 and long-term outcomes were investigated by Kaplan-Meier methods. Risk factors for adverse events "death or recurrent aortic insufficiency (AI) with or without aortic valve reoperation" were analyzed by using Cox proportional hazard models. Mean age was 33.1±14.5 years, and 38 patients (64%) were male. Marfan syndrome (MFS) accounts for 47 patients (80%). Only one patient was with bicuspid aortic valve. No in-hospital mortality was observed. Mean follow-up was 4.9±2.4 years. Estimated survival was 94.0±3.4% at 5 years. Freedoms from aortic valve reoperation and recurrent AI greater than mild were 95.7±3.0% and 88.9±4.7% at 5 years, respectively. In Cox proportional hazard analysis, preoperative AI greater than mild and Z score of annular diameter were significant risks for adverse events (p=0.027 and 0.045, hazard ratio 6.084 and 1.432, 95% C.I. 1.225-30.21 and 1.008-2.035, respectively). Even in Marfan-characterized population, David V-UT provided satisfactory long-term outcome, comparable to other VSARR modifications. It is simple but can freely reproduce trilobed sinus with one straight

  6. Análisis, diseño e implementación de un geoportal de rastreo satelital para la empresa David & Emily Import Company S.A.

    OpenAIRE

    Chicaiza Mora, Cristian Ricardo

    2016-01-01

    The David &.Emily Import Company S.A., has an high consumption of fuel on delivery vehicles, which increases transportation costs and the amount of travel for the clearance of goods. A tracking system of the busiest routes and also records the time spent on them, would improve delivery times and may get cost economic savings. This project proposes the development and implementation of a geoportal, that it can constantly monitor the delivery trucks used in the delivery of goods with a real-...

  7. David Schimmelpenninck van der Oye and Bruce W. Menning, eds., Reforming the Tsar's Army: Military Innovation in Imperial Russia from Peter the Great to the Revolution, Washington, DC: Woodrow Wilson Center and Cambridge: Cambridge UP, 2004.

    Directory of Open Access Journals (Sweden)

    David Stone

    2006-11-01

    Full Text Available David Schimmelpenninck and Bruce Menning have produced an excellent volume collecting contributions of a number of both well-established and junior scholars on the history and development of the tsarist military, grouped together around the general theme of reform. In some ways, it is comparable to Eric Lohr and Marshall Poe's complementary The Military and Society in Russia, 1450-1917 (Leiden, 2002. Schimmelpenninck and Menning's contributors, however, focus more on political and institutio...

  8. Imagining Exodus for Israel-Palestine: Reading the Secular and the Sacred, Diaspora and Homeland, in Edward Said and David Grossman

    Directory of Open Access Journals (Sweden)

    Anna Hartnell

    2005-03-01

    Full Text Available This paper takes as its starting point Edward Said's distinction between 'religious' and 'secular' modes of cultural affiliation. As these simultaneously diverging and converging modes also trammel the particular grounds of thinking that have been Said's natural target of criticism - Zionism - his work speaks particularly powerfully to the debate surrounding the religious genealogy of Jewish identity. This paper argues that Said's interventions on Zionism highlight as problematic the position whereby the 'Ingathering of the Exiles' is promoted as coexisting with a 'diasporic consciousness' nurtured by Judaism during exile; messianic hopes of religious Jews cannot be reconciled with physical return to the Promised Land; identity circumscribed by ethnicity and place cannot stand in as exemplary for the exiled, unsettled and ultimately homeless identity trumpeted by discourses of the 'post', as many contemporary theorists would have it. And yet through an exploration of the writings of David Grossman, whose construction of Jewish identity is envisaged through the regulating, competing and collaborating tropes of Zionism and Diaspora, I argue that this position is crucial for the elaboration of Israeli identity. I also argue that in fact there is room within Said's thinking both for the anti-essentialist elaboration of 'homeless' identities as well as 'the permission to narrate' an identity politics, and that his own distinction between the 'secular' and the 'religious' begins to disassemble. I explore this blurring of the sacred and the secular through the prism of Exodus - as both concept and narrative. This paper suggests that it is precisely Said's achievement to embody these tensions between religion and its other, divine providence and human agency, historical materialism and postmodernism, alienation and its perennially tempting opposite: home.

  9. David Bowie and the Art of Slow Innovation: A Fast-Second Winner Strategy for Biotechnology and Precision Medicine Global Development.

    Science.gov (United States)

    Özdemir, Vural; Patrinos, George P

    2017-11-01

    Original ideas and innovation cannot always be ordered like a courier service and delivered fresh to our desk at 9 am. Yet, most creativity-based organizations, careers, and professions, science and biotechnology innovation included, emphasize the speed as the prevailing ideology. But a narrow focus on speed has several and overlooked shortcomings. For example, it does not offer the opportunity to draw from, and stitch together disparate concepts and practices for truly disruptive innovation. Preventing false starts, learning from others' or our own mistakes, and customizing innovations for local community needs are difficult in a speed-hungry innovation ecosystem. We introduce a new strategy, the Fast-Second Winner, specifically in relation to global development of biotechnologies and precision medicine. This à la carte global development strategy envisions a midstream entry into the innovation ecosystem. Moreover, we draw from the works of the late David Bowie who defied rigid classifications as an artist and prolific innovator, and introduce the concept and practice of slow innovation that bodes well with the Fast-Second Winner strategy. A type of slow innovation, the Fast-Second Winner is actually fast and sustainable in the long term, and efficient by reducing false starts in new precision medicine application contexts and geographies, learning from other innovators' failures, and shaping innovations for the local community needs. The establishment of Centers for Fast-Second Innovation (CFSIs), and their funding, for example, by crowdfunding and other innovative mechanisms, could be timely for omics and precision medicine global development. If precision medicine is about tailoring drug treatments and various health interventions to individuals, we suggest to start from tailoring new ideas, and focus not only on how much we innovate but also what and how we innovate. In principle, the Fast-Second Winner can be applied to omics and other biotechnology

  10. Development testing of the chemical analysis automation polychlorinated biphenyl standard analysis method during surface soils sampling at the David Witherspoon 1630 site

    International Nuclear Information System (INIS)

    Hunt, M.A.; Klatt, L.N.; Thompson, D.H.

    1998-02-01

    The Chemical Analysis Automation (CAA) project is developing standardized, software-driven, site-deployable robotic laboratory systems with the objective of lowering the per-sample analysis cost, decreasing sample turnaround time, and minimizing human exposure to hazardous and radioactive materials associated with DOE remediation projects. The first integrated system developed by the CAA project is designed to determine polychlorinated biphenyls (PCB) content in soil matrices. A demonstration and development testing of this system was conducted in conjuction with surface soil characterization activities at the David Witherspoon 1630 Site in Knoxville, Tennessee. The PCB system consists of five hardware standard laboratory modules (SLMs), one software SLM, the task sequence controller (TSC), and the human-computer interface (HCI). Four of the hardware SLMs included a four-channel Soxhlet extractor, a high-volume concentrator, a column cleanup, and a gas chromatograph. These SLMs performed the sample preparation and measurement steps within the total analysis protocol. The fifth hardware module was a robot that transports samples between the SLMs and the required consumable supplies to the SLMs. The software SLM is an automated data interpretation module that receives raw data from the gas chromatograph SLM and analyzes the data to yield the analyte information. The TSC is a software system that provides the scheduling, management of system resources, and the coordination of all SLM activities. The HCI is a graphical user interface that presents the automated laboratory to the analyst in terms of the analytical procedures and methods. Human control of the automated laboratory is accomplished via the HCI. Sample information required for processing by the automated laboratory is entered through the HCI. Information related to the sample and the system status is presented to the analyst via graphical icons

  11. Colonial Empires of the East and the Eest: Images of the Other, from Tacito to David Malouf, from Salman Rushdie to Michael Ondaatje

    Directory of Open Access Journals (Sweden)

    Elvira Gòdono

    2011-11-01

    Full Text Available Many centuries before Joseph Conrad’s Heart of Darkness (1902 and Rudyard Kipling’s Kim (1901 were published, the East and West were still divided, as in Tacito’s De Germania, by a limes also visible in David Malouf’s An Imaginary Life (1978, in which the poet Ovid exiled at Tomi, is friends with the savage Child, of animal nature in a human body, similar to the metamorphic migrants of Salman Rushdie’s The Satanic Verses (1988, which hides the magnificent and ancient East of Mahābhārata and Rāmāyana in many Western identities, lost in diabolic European cities. This chaotic antithesis in Michael Ondaatje’s pages lets Sri Lanka’s childish ghosts float amidst stories of peregrination and in search of a Promised Land. In the Skin of a Lion (1987 includes an epigraph from the ancient poem of Gilgamesh, an Eastern echo in a novel profoundly important for many Western studies that often focus on the theory of the canon or on postmodern literature. These categories are discussed with the prospect of broadening cultural and post-colonial studies, in order to merge theory of genres and thematic criticism with anthropology, mythology, and ethnology. Multiple citations expand the original object of research, adding the colonial prophecy present in North American myths, as demonstrated by Margaret Atwood, Margaret Laurence or Lévi-Strauss. Incessantly moving from one space to another, authors give voice to the native cry from multiple perspectives, narrating – like all colonial empires founded on human cruelty– the beast’s nature that has shown its worst aspect.

  12. King David and the Frog

    Directory of Open Access Journals (Sweden)

    Marina Ritzarev

    2015-04-01

    Full Text Available The interrelations between the liturgical and paraliturgical genres of sacred music in both live practice and in historiography are explored. Parallels are found between eighteenth-century Russian and modern Hebrew religious music. The author's theory of the vernacular in music is applied to explain the stylistic openness in paraliturgical music (as a parallel to onto-vernacular folklore. 

  13. Edetabelitest ja eetikast / David Vseviov

    Index Scriptorium Estoniae

    Vseviov, David, 1949-

    2009-01-01

    Eri pingeread tähendavad erinevaid maailmu. Kuid kui ühiskond jaguneb erinevatesse, vaid omataolistest koosnevatesse gruppidesse, võib see olla vägagi ohtlik. Elades vaid oma maailmas võib kaotada orientatsiooni otsuste vastuvõtmiseks väljapoole seda maailma jäävates küsimustes. Seetõttu osutub sellistest gruppidest koosnev ühiskond võimu poolt kergesti manipuleeritavaks

  14. Lambanahka varjunud hundid / David Vseviov

    Index Scriptorium Estoniae

    Vseviov, David, 1949-

    2006-01-01

    Vastukaja 23. märtsil Eesti Päevalehes ilmunud Kaarel Tarandi artiklile "Kommar ja nommar". Autor peab nõukogude ajajärgu käsitlemisel kommunistide ja mittekommunistide vahele minevikuhinnangulise piiri tõmbamist ohtlikuks lihtsustamiseks

  15. OurTube / David Talbot

    Index Scriptorium Estoniae

    Talbot, David

    2009-01-01

    USA California Ülikooli töötajate Abram Stern'i ja Michael Dale'i poolt 2005. a. algatatud USA kongressis peetud kõnede videoremiksidest ja nende poolt loodud veebisaidist Metavid.org. Ka YouTube keskkonnast ja wikipedia katsetustest muuta oma keskkond multimeedialisemaks

  16. Once a physicist: David Florence

    Science.gov (United States)

    Florence, David

    2009-03-01

    I did mathematical physics because it was just what I was best at. I enjoyed it at school, so I applied to do it at Nottingham University. I fell into it, to be quite honest. Once at university, I struggled at first, partly because I found it quite difficult to combine studying with competing and training in sport, which is pretty much full time as well. But by the end of my university career, I had learned to be organized, and to manage my time pretty effectively, so I enjoyed it a lot more.

  17. Lepingud ja ajalugu / David Vseviov

    Index Scriptorium Estoniae

    Vseviov, David, 1949-

    2009-01-01

    Lepingute sõlmimine ei ole ühekordne lõplik diplomaatiline akt, vaid protsess. Leping ei ole ajaloos olnud iseenesest mingi garantii. Väikeriigi diplomaatia üks peamisi ülesandeid on oskus end iseseisvana kasulikuks teha

  18. Milleks teatrilavale ajalugu? / David Vseviov

    Index Scriptorium Estoniae

    Vseviov, David, 1949-

    2008-01-01

    Lavastused Konstantin Pätsist ja Gustav Naanist ajaloolisest taustast lähtudes: Rahvusooperis Estonia etendunud Katri Aaslav-Tepandi ja Tõnu Tepandi dokumentaaldraama "President 1939" Katri Aaslav-Tepandi lavastuses ja Eesti Draamateatris etendunud Enn Vetemaa, Erki Aule ja Merle Karusoo dokumentaallavastus "Sigma Tau-C705" Merle Karusoo lavastuses

  19. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Barometric pressure sensor, Carbon dioxide (CO2) gas analyzer and other instruments from NOAA Ship DAVID STARR JORDAN in the Gulf of California and North Pacific Ocean from 2006-08-06 to 2006-12-07 (NODC Accession 0084176)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0084176 includes Surface underway, chemical, meteorological and physical data collected from NOAA Ship DAVID STARR JORDAN in the Gulf of California...

  20. Temperature profile and other data collected using bottle and CTD casts from NOAA Ship DAVID STARR JORDAN and other platforms from Coastal Waters of California during the California Cooperative Fisheries Investigation (CALCOFI) project, 1977-11-29 to 1978-08-27 (NODC Accession 8600260)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oceanographic Station Data, temperature, and other data were collected using CTD and bottle casts from NOAA Ship DAVID STARR JORDAN and other platforms from the...

  1. Temperature profile and other data collected using bottle and CTD casts from the A. AGASSIZ and NOAA Ship DAVID STARR JORDAN from the Coastal Waters of California during the California Cooperative Fisheries Investigation (CALCOFI) project, 26 January 1974 to 13 November 1975 (NODC Accession 8600370)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oceanographic Station Data, temperature, and other data were collected using CTD and bottle casts from A. AGASSIZ and NOAA Ship DAVID STARR JORDAN from the Coastal...

  2. Temperature profile and other data collected using bottle and CTD casts from NOAA Ship DAVID STARR JORDAN and other platforms from Coastal Waters of California during the California Cooperative Fisheries Investigation (CALCOFI) project, 1985-02-19 to 1985-11-14 (NODC Accession 8700010)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oceanographic Station Data, temperature, and other data were collected using CTD and bottle casts from NOAA Ship DAVID STARR JORDAN, NOAA Ship McARTHUR, and NEW...

  3. Chemical, physical, and other data collected using meteorological sensors, secchi disk, and bottle casts from NOAA Ship DAVID STARR JORDAN as part of the California Cooperative Fisheries Investigation (CALCOFI) project, from 1975-09-14 to 1975-09-20 (NCEI Accession 8900074)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical, physical, and other data were collected from NOAA Ship DAVID STARR JORDAN from September 14, 1975 to September 20, 1975. Data were collected using...

  4. Chemical, physical, and other data collected using meteorological sensors, secchi disk, and bottle casts from NOAA Ship DAVID STARR JORDAN as part of the California Cooperative Fisheries Investigation (CALCOFI) project, from 1975-06-08 to 1975-06-11 (NCEI Accession 8900073)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical, physical, and other data were collected from NOAA Ship DAVID STARR JORDAN from June 08, 1975 to June 11, 1975. Data were collected using meteorological...

  5. Temperature profile and other data collected using bottle and CTD casts from NOAA Ship DAVID STARR JORDAN and other platforms from the Coastal Waters of California during the California Cooperative Fisheries Investigation (CALCOFI) project, 1980-11-28 to 1984-11-06 (NODC Accession 8600053)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oceanographic Station Data, temperature, and other data were collected using CTD and bottle casts from NOAA Ship DAVID STARR JORDAN and other platforms from the...

  6. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Barometric pressure sensor, Carbon dioxide (CO2) gas analyzer and other instruments from NOAA Ship DAVID STARR JORDAN in the Channel Islands National Marine Sanctuary, Cordell Bank National Marine Sanctuary and others from 2007-07-25 to 2007-10-28 (NCEI Accession 0144352)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0144352 includes Surface underway data collected from NOAA Ship DAVID STARR JORDAN in the Channel Islands National Marine Sanctuary, Cordell Bank...

  7. Chemical, physical, and other data collected using bottle casts from NOAA Ship DAVID STARR JORDAN, ROGER REVILLE, and NEW HORIZON as part of the California Cooperative Fisheries Investigation from 1996-08-07 to 1997-04-19 (NODC Accession 9800118)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical, physical, and other data were collected from NOAA Ship DAVID STARR JORDAN, ROGER REVILLE, and NEW HORIZON from August 7, 1996 to April 19, 1997. Data were...

  8. Chemical, physical, and other data collected using fluorometer, laboratory analysis, visual analysis, and bottle casts from NOAA Ship DAVID STARR JORDAN and NEW HORIZON as part of the California Cooperative Fisheries Investigation (CALCOFI) project, from 1992-01-28 to 1994-10-14 (NODC Accession 9500048)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical, physical, and other data were collected from NOAA Ship DAVID STARR JORDAN and NEW HORIZON from January 28, 1992 to October 14, 1994. Data were collected...

  9. A Study of Business Ethical Thought in David Mamet' s American Buffalo%《美国野牛》的商业伦理思想

    Institute of Scientific and Technical Information of China (English)

    蔡隽

    2012-01-01

    本文依据大卫.马梅特以伦理为"第一原则"的创作思想,从伦理的角度解读其成名剧《美国野牛》,试图揭示其中蕴涵的伦理关怀。马梅特是一位极富道德忧患意识和社会责任感的创新作家,在《美国野牛》中,他通过表面简单的抢劫情节生动地展现了剧中人物将商业与道德分离的伦理思想,质疑其对个人生活及人际交往造成的破坏性影响;又通过剧中人物看似随意的对话巧妙地揭示出个体内心深处潜藏的对与他人结成积极联系的渴求,肯定友谊与诚信的伦理价值。马梅特借助"简单"的情节与"随意"的对话糅合对社会现实的批判和对伦理理想的表现,表达自己的商业伦理追寻。%This paper makes a textual study of David Mamet' s breakthrough play American Buffalo on the perspective of ethic based on his literary creation thought and attempts to reveal the hidden ethical connotation of the work. As an innovative playwright with moral concern and a sense of social responsibility, Mamet reveals the characters' improper ethic separating business from morality through the superficially simple plot of robbery and condemns its destructive influ- ence upon personal life and interpersonal relation ; then, he reveals the individual' s craving for positive contacts with others through the characters' seemingly idle talk and affirms the ethical value of friendship and honesty. This essay argues that Mamet expresses his own business ethic through his criticism of social reality and his affirmation of the the ethical ideal by use of " simple plot" and "idle talk".

  10. De David Belasco à Giacomo Puccini : La Fanciulla del West, premier opéra « américain » From David Belasco to Giacomo Puccini:La Fanciulla del West, first “American” opera

    Directory of Open Access Journals (Sweden)

    Walter Zidaric

    2009-10-01

    Full Text Available La Fanciulla del West is a “horse opera” resulting from the second collaboration between David Belasco and Giacomo Puccini. This work, specially composed for the American stage, which had its world premiere at New York’s Metropolitan Opera in December 1910, paved the way for American composers who increasingly focused on American History in their quest for a “national” opera. For the first time, Puccini resorted to genuine Indian music, a Zuni melody, which he re-elaborated for dramatic purposes and associated with the nostalgic mood of uprooted people, the miners who left their home country for America. The Other – the native American viewed from the vantage point of the white, as well as the foreigner – no longer represented a threat, as had been the case in the operatic repertoire before, but became part and parcel of a multicultural society, like the Italian immigrant to whom Puccini also paid tribute. The Zuni melody, which opens and closes the opera, contributes to giving a genuine twist to a score which is the first one to tackle the foundations of the American nation.

  11. Fuck the casual viewer. Ciudad, poder y comunicación en la obra audiovisual de David Simon. Análisis de The Corner, The Wire, Treme y Show me a hero

    OpenAIRE

    Ogando Des, Luis Antonio

    2017-01-01

    La obra audiovisual del ex – periodista David Simon, constituye un amplio estudio urbano sobre la ciudad postindustrial en la sociedad de consumo y en un mundo globalizado. Un estudio cimentado en el análisis de las instituciones, las dinámicas de poder y comunicación que se establecen entre los actores urbanos, los conflictos que dichas dinámicas generan, las transformaciones del espacio urbano y los principales problemas de las ciudades en el estadio actual del sistema capitalista. Dada la ...

  12. The PRECiSE 2 trial of certolizumab pegol, a new PEGylated anti-TNF agent, in the treatment of Crohn's disease - An interview with David A Schwartz, 13 June 2007

    Directory of Open Access Journals (Sweden)

    David A Schwartz

    2008-03-01

    Full Text Available David A SchwartzVanderbilt University Medical Center, Nashville, TN, USAContext: Certolizumab pegol (CDP 870 is a new anti-tumor necrosis factor (TNF therapy currently in development for the treatment of Crohn’s disease, rheumatoid arthritis, and psoriasis. Certolizumab pegol is the first PEGylated biologic anti-TNF agent and has a high binding affinity for TNF. Dr. Schwartz was an investigator of the PRECiSE (PEGylated Antibody Fragment Evaluation in Crohn’s Disease Safety and Efficacy 2 trial of certolizumab pegol in patients with Crohn’s disease.Keywords: certolizumab pegol, PRECiSE 2 trial, Crohn’s disease

  13. Illustrations to “Gespräche in dem Reiche derer Todten zwischen dem vortreflichen Moscowitischen Czaar Petro Magno und dem grossen Tyrannen Ivan Basilowiz II” (Peter the Great and Ivan the Terrible) by David Fassmann (1725)

    OpenAIRE

    Ekaterina A. Skvortcova

    2017-01-01

    The journal created by David Fassmann (1683–1744), Gespräche in dem Reiche derer Todten, edited in Leipzig, was a huge success. Each of the 240 issues presents a dialogue between two historical figures from the afterworld. In the 83rd–86th Entrevuë, the interlocutors are Peter the Great and Ivan the Terrible. The texts of the four conversations were thoroughly examined by Eckhard Matthes (1987). The present paper explores how the illustrations to the 83rd–86th Entrevuë visualize the texts, w...

  14. Les vieux maîtres et les jeunes génies Old masters and young geniuses : artistic temporality, creativity and recognition according to David Galenson

    Directory of Open Access Journals (Sweden)

    Nathalie Heinich

    2011-10-01

    Full Text Available Cet article rend compte d’un ouvrage de l’économiste américain David W. Galenson consacré aux « deux cycles de vie de la créativité artistique » et à leurs prolongements dans différents domaines, y compris scientifique. Il en propose quelques applications à l’art contemporain, en suggérant notamment, à partir d’un exemple concret, que la question des temporalités pourrait aussi être étendue avec profit aux modalités de la reconnaissance en art.This paper provides an in-depth review of a book published by the American economist David W. Galenson on the “two cycles of artistic creativity” and their developments in various domains, including science. It offers a few applications to contemporary art, before demonstrating, out of a specific case, that the issue of temporalities should also be extended to the modes of artistic recognition.

  15. Universal Alienation, Formal and Real Subsumption of Society Under Capital, Ongoing Primitive Accumulation by Dispossession: Reflections on the Marx@200-Contributions by David Harvey and Michael Hardt/Toni Negri

    Directory of Open Access Journals (Sweden)

    Christian Fuchs

    2018-05-01

    Full Text Available This contribution presents reflections on the contributions of and the debate between David Harvey and Michael Hardt/Toni Negri that we feature as the opening part of the tripleC-special issue “Marx@200: Debating Capitalism & Perspectives for the Future of Radical Theory”. My reflection contextualises the debate by a discussing the origin and genesis of Marx’s concepts of alienation, formal/real subsumption, and primitive accumulation and b situating the arguments in earlier works by Harvey, Hardt and Negri. This paper points out differences as well as the strong commonalities between the works of Michael Hardt/Toni Negri and David Harvey. It discusses how the categories of universal alienation, formal/real subsumption of society under capital, original/ongoing primitive accumulation of capital are related. Harvey and Hardt/Negri show that Marx’s theory and politics are alive 200 years after his birth and will haunt capitalism as long as it exists. The paper concludes by arguing that Harvey’s concept of anti-value and the autonomous notion of self-valorisation point towards democratic, commons-based alternatives to capitalism.

  16. Indicadores acerca da importância do papel do professor no processo de formação continuada do aluno: um ensaio a partir da Teoria da Aprendizagem Significativa de David Ausubel

    OpenAIRE

    Romualdo Santos Silva Jr.

    2017-01-01

    A interação entre professor e aluno desempenha uma grande evolução na aprendizagem do aluno, tanto antes, quanto após o ensino médio, através da convivência de respeito entre os mesmos, tendo como consequência a ocorrência de mudança na relação cultural e profissional do aluno na sociedade. A fim de analisar e compreender esta relação durante e após o ensino médio, este ensaio buscou na literatura aspectos à luz da teoria da aprendizagem significativa de David Ausubel, que pudesse promover, o...

  17. Comment Hollywood figure l’intériorité dans les films « hollywoodiens » de David Lynch, Lost Highway (1997, Mulholland Dr. (2001 et Inland Empire (2006

    Directory of Open Access Journals (Sweden)

    David ROCHE

    2011-09-01

    Full Text Available L’article prend comme point de départ les travaux de Zachary Baqué et vise à montrer, à travers une étude diachronique, que les films hollywoodiens de Lynch ne le sont pas uniquement par leur représentation satirique d’un système corrompu qui compromet les ambitions qu’il suscite, ni même par la façon dont il retravaille les conventions génériques et narratives propres au cinéma hollywoodien. Hollywood est une présence à la fois horizontale et verticale, physique et abstraite, réelle et imaginaire, qui renvoie à la ville, au système, au cinéma et au rêve, si bien que la satire, la topographie, les motifs visuels parfois clichés et les références filmiques sont intimement liés en une expression de la subjectivité et de l’intérioritéThe article takes Zachary Baqué’s study of Los Angeles in the films of David Lynch as a starting point to explore David Lynch’s Hollywood movies. The author contends that the films offer more than a satirical representation of a corrupt, unhealthy system which threatens dreams and artistic creativity, or a parodic play on Hollywood genre and narrative conventions. Rather, Hollywood is a character, a presence, revealed as both horizontal and vertical, physical and abstract, evoking the city, the studio system, cinema and dreams, so that the satire, the visual motifs and clichés and the topography of Hollywood, and the references to Hollywood films, constitute a complex fabric of subjectivity and interiority.

  18. Resultados da assistência ao parto no Centro de Parto Normal Dr. David Capistrano da Costa Filho em Belo Horizonte, Minas Gerais, Brasil Results of childbirth care at a birthing center in Belo Horizonte, Minas Gerais, Brazil

    Directory of Open Access Journals (Sweden)

    Sibylle Emilie Vogt Campos

    2007-06-01

    Full Text Available A qualidade da assistência prestada em Centro de Parto Normal (CPN por enfermeira obstetra é amplamente questionada. Foi realizado um estudo descritivo e retrospectivo de 2.117 partos ocorridos entre janeiro de 2002 e julho 2003, no CPN Dr. David Capistrano da Costa Filho, em Belo Horizonte. Entre os principais resultados da assistência, destacam-se a taxa de transferência materna com 11,4%; a taxa de cesárea com 2,2%; a taxa de admissão em Centro de Tratamento Intensivo (CTI neonatal de 1,2%; e a taxa de Apgar This was a descriptive and retrospective study of 2,117 deliveries from January 2002 to July 2003 at the Dr. David Capistrano da Costa Filho Birthing Center in Belo Horizonte, Minas Gerais, Brazil. Widespread questions have been raised concerning the quality of services provided at birthing centers by obstetric nurses. The results of the current study were: 11.4% maternal transfer rate; 2.2% cesarean sections; 1.2% neonatal ICU admissions; and 1% 5-minute Apgar scores below 7. Delivery dystocia and the request for epidural anesthesia were the main reasons for maternal transfer, and respiratory distress was the main cause of neonatal ICU admission. Corrected neonatal mortality was 2 per 1,000 live births. The results at this birthing center did not differ significantly from those in a review of the international literature. The most striking finding was the low cesarean rate. Comparative studies and more comprehensive national data on low-risk gestations are needed.

  19. 李嘉图与曼德维尔经济伦理思想的分歧%The Differences of Economic Ethics between David Ricardo and Bernard Mandeville

    Institute of Scientific and Technical Information of China (English)

    孙尚诚

    2012-01-01

    Both David Ricardo and Bernard Mandeville made great contribution to the development of modern economic thought. The former is a representative of utilitarianism, and the latter is a representative of egotism. Although they all emphasized the role of personal interests acting on social interests, there are fundamental differences between them. When the principle of general happiness, which was put forward by the David Ricardo, is regarded as an example, compared with " private vices, public benefits" which was put forward by Bernard Mandeville, we can find the fundamental differences between the two schools obviously. And the most important difference is that egoism has deliberately despised the social morality, but utilitarianism has never given up the pursuit of justice.%大卫·李嘉图和伯纳德·曼德维尔都对经济思想的形成和发展作出了很大贡献。前者代表的是功利主义,后者代表的则是利己主义。尽管他们都强调个人利益对社会利益的作用,但二者之间又有根本的分歧。以李嘉图的一般幸福原则为例,并与伯纳德·曼德维尔的“私恶即公利”进行对比。就可以明显看出两个学派的根本歧异。其中最重要的歧异就在于,利己主义显然有意地藐视了社会的道德,而功利主义却从来没有放弃过对于公正的追求。

  20. Vene Teatri juht Marek Demjanov vaatab tänasesse päeva / Marek Demjanov ; interv. Andres Keil

    Index Scriptorium Estoniae

    Demjanov, Marek

    2006-01-01

    Teatri remondi käigust, pikemalt kevadel Moskvast naasvatest noortest näitlejatest (õppisid neli aastat Moskva Kunstiteatri koolstuudios), publikust. Lisatud Marek Demjanovi eluloolised andmed ja Vene Teatri tegevuskava 2006