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  1. Endopancreatic Bile Duct Cholangiocarcinoma in a Patient with Peutz-Jeghers Syndrome

    Directory of Open Access Journals (Sweden)

    Alexandros K. Charalabopoulos

    2011-01-01

    Full Text Available Peutz-Jeghers syndrome is a rare autosomal dominant inherited disease characterized by a special type of hamartomatous gastrointestinal polyps combined with mucocutaneous melanin pigmentations. Patients with the syndrome have a high risk of developing neoplasia, with colon, small bowel, and stomach being the most common gastrointestinal sites. Herein, we present the occurrence of a rare tumor in patients with Peutz-Jeghers syndrome; a cholangiocarcinoma of the endopancreatic bile duct. A minireview is also presented. It can be concluded that cholangiocarcinoma remains a possible diagnosis in PJS patients, as in others that present with biliary obstruction. PJS patients may be at higher risk than others in view of their propensity for malignancy.

  2. Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance

    NARCIS (Netherlands)

    Korsse, Susanne E.; Harinck, Femme; van Lier, Margot G. F.; Biermann, Katharina; Offerhaus, G. Johan A.; Krak, Nanda; Looman, Caspar W. N.; van Veelen, Wendy; Kuipers, Ernst J.; Wagner, Anja; Dekker, Evelien; Mathus-Vliegen, Elisabeth M. H.; Fockens, Paul; van Leerdam, Monique E.; Bruno, Marco J.

    2013-01-01

    Although Peutz-Jeghers syndrome (PJS) is known to be associated with pancreatic cancer (PC), estimates of this risk differ widely. This hampers counselling of patients and implementation of surveillance strategies. We therefore aimed to determine the PC risk in a large cohort of Dutch PJS patients.

  3. Disease pattern in Danish patients with Peutz-Jeghers syndrome

    DEFF Research Database (Denmark)

    Jelsig, A M; Qvist, N; Sunde, L

    2016-01-01

    in the GI tract, mucocutaneous pigmentations, and an increased risk of cancer in the GI tract and at extraintestinal sites. Over 90 % of patients harbour a pathogenic mutation in STK11. METHODS: Based on the Danish Pathology Data Bank, the Danish National Patient Register, as well as information from...

  4. Peutz-Jeghers Syndrome with Synchronous Adenocarcinoma Arising from Ileal Polyps

    OpenAIRE

    Sharma, Mohit; Singh, Rachhpal; Grover, Anumeet Singh

    2014-01-01

    Peutz-Jeghers syndrome is a rare inherited autosomal disease characterized by mucocutaneous pigmentation and multiple polyps in the gastrointestinal tract. The clinical picture is characterized by repeated episodes of polyp-induced intestinal obstruction, abdominal pain, and bleeding per rectum. Predisposition to both gastrointestinal and nongastrointestinal malignancies is increased in a patient with Peutz-Jeghers syndrome. This is a case report of a 29-year-old male with Peutz-Jeghers syndr...

  5. Multiple Intussusceptions as Primary Manifestation of Peutz-Jeghers Syndrome: Report of a Case

    OpenAIRE

    Ahmad Amouzeshi; Mohammad-Reza Motie; Ali Najib Jalali

    2009-01-01

    Background: Peutz-Jeghers syndrome is a rare hereditary disorder characterized by hamartomatous polyps in the gastrointestinal tract and typical pigment lesions. It is a rare cause of multiple intussusceptions. Previous studies on Peutz-Jeghers syndrome reported only one case of multiple intussusceptions. We describe a case of appendiceal and multiple small intestine intussusceptions presenting as peritonitis in a patient with Peutz-Jeghers syndrome. Case Presentation:A 17-year-old girl prese...

  6. Clinical and Genetic Analysis of Peutz-Jeghers Syndrome Patients in Taiwan

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    Meng-Tzu Weng

    2010-05-01

    Conclusion: Compared with other countries, PJS patients in Taiwan tended to have more extensive polyps in the gastrointestinal tract, with intussusception being the most common abdominal symptom. Mutations in the LKB1 gene were identified in 57% of the probands in Taiwan.

  7. Wireless capsule endoscopy for evaluation of phenotypic expression of small-bowel polyps in patients with Peutz-Jeghers syndrome and in symptomatic first-degree relatives.

    Science.gov (United States)

    Soares, J; Lopes, L; Vilas Boas, G; Pinho, C

    2004-12-01

    Peutz-Jeghers syndrome (PJS) is an inherited gastrointestinal hamartomatous polyposis disorder. Small-bowel intussusception and bleeding are the most common complications, and malignancy may also occur. Survey of the gastrointestinal tract, particularly of the small bowel, is difficult and current recommendations for management syndrome are ambiguous. We evaluated the feasibility of capsule endoscopy for identifying phenotypic expression of small-bowel polyps in patients with full-blown PJS and a previous diagnosis of gastrointestinal polyposis, and in symptomatic kindred of PJS patients with no previous diagnosis of gastrointestinal polyposis. Two groups were studied: group A consisted of 14 patients with gastrointestinal polyposis, eight of whom had undergone previous small-intestine surgery; group B consisted of six symptomatic first-degree relatives of PJS patients; these patients had previous negative gastrointestinal endoscopic examinations. Numerous polyps were detected in all patients in group A. Most polyps were sessile, but the larger polyps tended to be pedunculated. Polyp density was highest in the jejunum (greater than in the ileum and duodenum). Seven patients had at least one large polyp (> 11 mm) and five of these patients subsequently underwent enteroscopy, which revealed that capsule endoscopy had correctly identified all the patients with large polyps, but had missed 20 % of the total number of large polyps in these patients. No polyps were detected by capsule endoscopy in group B patients, despite the excellent visualization of the small intestine. In all patients, the capsules were expelled within 24 hours, without complications, and the procedure was well tolerated. Capsule endoscopy is an effective and well-tolerated method for evaluating small-bowel pathology in patients with PJS.

  8. Very high risk of cancer in familial Peutz-Jeghers syndrome

    NARCIS (Netherlands)

    Giardiello, F. M.; Brensinger, J. D.; Tersmette, A. C.; Goodman, S. N.; Petersen, G. M.; Booker, S. V.; Cruz-Correa, M.; Offerhaus, J. A.

    2000-01-01

    The Peutz-Jeghers syndrome (PJS) is an autosomal dominant polyposis disorder with increased risk of multiple cancers, but literature estimates of risk vary. We performed an individual patient meta-analysis to determine the relative risk (RR) of cancer in patients with PJS compared with the general

  9. Findings from the Peutz-Jeghers syndrome registry of uruguay.

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    Asadur Tchekmedyian

    Full Text Available BACKGROUND: Peutz-Jeghers syndrome (PJS is characterized by intestinal polyposis, mucocutaneous pigmentation and an increased cancer risk, usually caused by mutations of the STK11 gene. This study collected epidemiological, clinical and genetic data from all Uruguayan PJS patients. METHODS: Clinical data were obtained from public and private medical centers and updated annually. Sequencing of the STK11 gene in one member of each family was performed. RESULTS AND DISCUSSION: 25 cases in 11 unrelated families were registered (15 males, 10 females. The average age of diagnosis and death was 18 and 41 years respectively. All patients had characteristic PJS pigmentation and gastrointestinal polyps. 72% required urgent surgery due to intestinal obstruction. 3 families had multiple cases of seizure disorder, representing 20% of cases. 28% developed cancer and two patients had more than one cancer. An STK11 mutation was found in 8 of the 9 families analyzed. A unique M136K missense mutation was noted in one family. Comparing annual live births and PJS birth records from 1970 to 2009 yielded an incidence of 1 in 155,000. CONCLUSION: The Uruguayan Registry for Peutz-Jeghers patients showed a high chance of emergent surgery, epilepsy, cancer and shortened life expectancy. The M136K missense mutation is a newly reported STK 11 mutation.

  10. Findings from the Peutz-Jeghers syndrome registry of Uruguay

    KAUST Repository

    Tchekmedyian, Asadur

    2013-11-19

    Background: Peutz-Jeghers syndrome (PJS) is characterized by intestinal polyposis, mucocutaneous pigmentation and an increased cancer risk, usually caused by mutations of the STK11 gene. This study collected epidemiological, clinical and genetic data from all Uruguayan PJS patients. Methods: Clinical data were obtained from public and private medical centers and updated annually. Sequencing of the STK11 gene in one member of each family was performed. Results and discussion: 25 cases in 11 unrelated families were registered (15 males, 10 females). The average age of diagnosis and death was 18 and 41 years respectively. All patients had characteristic PJS pigmentation and gastrointestinal polyps. 72% required urgent surgery due to intestinal obstruction. 3 families had multiple cases of seizure disorder, representing 20% of cases. 28% developed cancer and two patients had more than one cancer. An STK11 mutation was found in 8 of the 9 families analyzed. A unique M136K missense mutation was noted in one family. Comparing annual live births and PJS birth records from 1970 to 2009 yielded an incidence of 1 in 155,000. Conclusion: The Uruguayan Registry for Peutz-Jeghers patients showed a high chance of emergent surgery, epilepsy, cancer and shortened life expectancy. The M136K missense mutation is a newly reported STK 11 mutation. © 2013 Tchekmedyian et al.

  11. Gastric diffuse hamartomatous polyposis as unique manifestation of peutz-jeghers syndrome.

    Science.gov (United States)

    Ruiz-Tovar, J; Gamallo, C

    2014-01-01

    Peutz-Jeghers-type hamartomatous polyps are most common in the small intestine, but can also occur in the stomach and large bowel. Gastric polyps usually coexist with hamartomatous polyps in other locations of the gastro-intestinal tract. We present the second case reported in literature of diffuse gastric polyposis without affecting the rest of the gastrointestinal tract. A 41-years-old woman complained of repeated, self-limited episodes of hematemesis. She presented with anaemia. An upper gastrointestinal endoscopy revealed multiple polyps in all the gastric surface, whose biopsy diagnosed of hamartomatous polyps. No other polyps were detecting the gastrointestinal tract. The patient underwent a total gastrectomy with Roux-en-Y reconstruction. Pathology revealed a gastric diffuse hamartomatous polyposis. A mis-sense mutation encoding the serine/threonine kinase STK11 gene was been identified, compatible with Peutz Jeghers polyposis. Copyright© Acta Chirurgica Belgica.

  12. Peutz-Jeghers Syndrome in Children: High Recurrence Rate in Short-term Follow-up

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    Tomoaki Taguchi; Sachiyo Suita; Shohei Taguchi; Shinji Tanaka

    2003-01-01

    We have managed four cases of Peutz-Jeghers syndrome (PJS) in children. Fathers of three of these patients had PJS. There was also a family history of cancer in three cases, with pancreatic cancer in a father, colonic and laryngeal cancers in a grandfather, and hepatic and gastric cancers in a grandmother. It is presumed that in each of the cases, the largest polyp was responsible for initial symptoms. Preoperative examination revealed additional small polyps in the whole alimentary tract exc...

  13. Intussusception due to Peutz-Jeghers syndrome - a case report and review of the literature

    International Nuclear Information System (INIS)

    Grasso Filho, Luiz Eduardo; Albertotti, Flavio; Carvalho, Claudio Sobral de; Nersessian, Ana Carolina; Docema, Marcos F. Lima; Ogasawara, Aparecida M.; Peng Yong Sheng; Costacurta, Marco Antonio; Albertotti, Cesar Jose; Cerri, Giovanni Guido

    2000-01-01

    The authors report a case of a 28-year-old woman with ileocecocolic intussusception due to Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by hamartomatous polyposis of the gastrointestinal tract and mucocutaneous pigmentation. This condition frequently presents complications such as intestinal obstruction due to invagination or hemorrhage. In this patient, the diagnosis of intussusception was made preoperatively. The excised material revealed three large polyps which were considered to be the cause of the intussusception. (author)

  14. Peutz-Jeghers syndrome and family planning: the attitude towards prenatal diagnosis and pre-implantation genetic diagnosis

    NARCIS (Netherlands)

    M.G.F. van Lier (Margot); S.E. Korsse (Susanne); E.M.H. Mathus-Vliegen (Elisabeth); E.J. Kuipers (Ernst); A.M.W. van den Ouweland (Ans); K. Vanheusden (Kathleen); M.E. van Leerdam (Monique); A. Wagner (Anja)

    2012-01-01

    textabstractPeutz-Jeghers syndrome (PJS) is a hereditary disorder caused by LKB1 gene mutations, and is associated with considerable morbidity and decreased life expectancy. This study was conducted to assess the attitude of PJS patients towards family planning, prenatal diagnosis (PND) and

  15. Peutz-Jeghers syndrome and family planning: the attitude towards prenatal diagnosis and pre-implantation genetic diagnosis

    NARCIS (Netherlands)

    van Lier, Margot G. F.; Korsse, Susanne E.; Mathus-Vliegen, Elisabeth M. H.; Kuipers, Ernst J.; van den Ouweland, Ans M. W.; Vanheusden, Kathleen; van Leerdam, Monique E.; Wagner, Anja

    2012-01-01

    Peutz-Jeghers syndrome (PJS) is a hereditary disorder caused by LKB1 gene mutations, and is associated with considerable morbidity and decreased life expectancy. This study was conducted to assess the attitude of PJS patients towards family planning, prenatal diagnosis (PND) and pregnancy

  16. Peutz-Jegher syndrome in childhood: need for updated recommendations?

    Science.gov (United States)

    Goldstein, Stephanie A; Hoffenberg, Edward J

    2013-02-01

    We reviewed our institution's experience with Peutz-Jegher syndrome (PJS) in children to determine whether current recommendations on timing of screening and follow-up should be modified. We reviewed the charts of all of the children with a diagnosis of PJS at our institution from 2000 to 2011 abstracting data on intussusceptions events, polyp characteristics, Sertoli cell (SC) tumors, family history, imaging, and interventions. Of 14 children identified, 10 were boys. Median age at first clinical evaluation was 4.5 years, and family history and/or mucocutaneous pigmentation were the 2 most common factors stimulating screening. Median age at first screening test was 5 years (range 1-16), and at first polyp identification, 5 years (range 1 to 18). There were 7 intussusception events in 5 children, with median age of 10 and range 5 to 16 for first event. Two boys had SC tumors at 8 and 11 years. Polyps were identified during initial screening in 9 of 14 patients. Polyps were found in the stomach or duodenum in 5 (36%), small bowel in 7, (50%) and colon in 3 (21%) children. Large polyps were identified in 9 children at median age of 7 years. Polyps causing significant clinical consequences can occur frequently in children with PJS younger than 8 years. Revised guidelines should consider initial screening at age 4 to 5 with capsule endoscopy and upper and lower endoscopy as well as evaluation for SC tumors and re-evaluation whenever symptoms suggest polyp-associated complications.

  17. Peutz-Jeghers syndrome: case report and literature review.

    Science.gov (United States)

    Georgescu, E F; Stănescu, Ligia; Simionescu, Cristiana; Georgescu, Iuliana; Ionescu, Reanina; Florescu, G

    2008-01-01

    Periorificial lentiginosis, also knew as Peutz-Jeghers Syndrome (PJS), is an autosomally dominant inherited condition determined by a mutation localized at 19p13.3 responsible for mucocutaneous pigmentation and gastrointestinal polyps. Skin- and mucosal pigmentation may be present at birth but usually occur in early childhood, and occasionally may develop later. Round, oval or irregular patches of brown or almost black pigmentation 1 to 5 mm diameter, irregularly distributed over the oral mucosa, gums, hard palate and lips (especially the lower) are observed. The pigmented maculae on the face, encountered especially around the nose and mouth are smaller. Polyps may appear in the stomach, small bowel or colon, with hamartomatous aspects on histology. Acute upper gastrointestinal bleeding and chronic fecal blood loss may appear during the course of disease. There is a higher risk of intestinal and extraintestinal cancers in those patients. We present the case of an 18-year-old young girl accusing since the age of 3 slight intermittent episodes of bloating and abdominal pain without a particular localization, as well as mild iron-deficiency anemia. Physical examination revealed pigmented lesions suggesting PSJ on the palatine and jugal mucosa while endoscopy found a lot of polyps in stomach and a few, isolated in the colon, all having the same hamartomatous pattern. The presence in early infancy of small, well-demarcated and dark-brown to blue-black lentigines on the lips, buccal mucosa and perioral skin, should alert the clinician to PJS.

  18. Peutz Jeghers Syndrome Presented as intermittent gastric outlet ...

    African Journals Online (AJOL)

    Peutz Jeghers Syndrome (PJS), which was first described in 1921 by Peutz, followed by Jeghers etal in 1949, is an uncommon but not a rare disorder characterized by mucocutaneous melanin pigmentation, gastrointestinal hamartomatous polyps and increased risk of gastrointestinal and other organs cancer. The polyps ...

  19. Recurrent small intestine intussusception in a patient with Peutz-Jeghers syndrome Invaginación recurrente del intestino delgado en un paciente con síndrome de Pentz-Jeghers

    OpenAIRE

    Orestis Ioannidis; Styliani Papaemmanouil; George Paraskevas; Anastasios Kotronis; Stavros Chatzopoulos; Athina Konstantara; Nikolaos Papadimitriou; Apostolos Makrantonakis; Emmanouil Kakoutis

    2012-01-01

    Peutz-Jeghers syndrome is a rare hereditary autosomal dominant disease caused by a mutation of the tumor suppressor gene serine/threonine kinase 11 located in chromosome 19p13.3. It is characterized by the presence of extensive mucocutaneous pigmentation, especially of the lips and the occurrence of hamartomatous polyps throughout the gastrointestinal tract. Gastrointestinal hamartomas occur predominantly in the small intestine and can become symptomatic leading usually to intestinal obstruct...

  20. Intussusception due to Peutz-Jeghers syndrome - a case report and review of the literature; Sindrome de Peutz-Jeghers e intussuscepcao - relato de um caso e revisao da literatura

    Energy Technology Data Exchange (ETDEWEB)

    Grasso Filho, Luiz Eduardo; Albertotti, Flavio; Carvalho, Claudio Sobral de; Nersessian, Ana Carolina; Docema, Marcos F. Lima; Ogasawara, Aparecida M.; Peng Yong Sheng [Hospital Sirio Libanes, Sao Paulo, SP (Brazil). Centro de Diagnostico por Imagem; Costacurta, Marco Antonio [Hospital Sirio Libanes, Sao Paulo, SP (Brazil). Servico de Radiologia Geral; Albertotti, Cesar Jose [Hospital Sirio Libanes, Sao Paulo, SP (Brazil). Servico de Tomografia Computadorizada; Cerri, Giovanni Guido [Hospital Sirio Libanes, Sao Paulo, SP (Brazil). Servico de Ultra-Som

    2000-02-01

    The authors report a case of a 28-year-old woman with ileocecocolic intussusception due to Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by hamartomatous polyposis of the gastrointestinal tract and mucocutaneous pigmentation. This condition frequently presents complications such as intestinal obstruction due to invagination or hemorrhage. In this patient, the diagnosis of intussusception was made preoperatively. The excised material revealed three large polyps which were considered to be the cause of the intussusception. (author)

  1. Genetic and epigenetic profiling of a solitary Peutz?Jeghers colon polyp

    OpenAIRE

    Linhart, Heinz; Bormann, Felix; Hutter, Barbara; Brors, Benedikt; Lyko, Frank

    2017-01-01

    Colon polyps represent precursor lesions of colon cancers and their malignant potential varies according to histological subtype. A rare subtype of colon polyps is the Peutz?Jeghers (PJ) polyp. PJ polyps mostly occur in the context of Peutz?Jeghers syndrome, which is characterized by the development of multiple polyps in the intestinal tract and hyperpigmentation of oral mucosa and lips. Peutz?Jeghers is an autosomal dominant disorder caused by pathogenic variants of the serine threonine kina...

  2. Breast ultrasound in the management of gynecomastia in Peutz-Jeghers syndrome in monozygotic twins: two case reports.

    Science.gov (United States)

    Di Grezia, Graziella; Romano, Tiziana; De Francesco, Francesco; Somma, Francesco; Rea, Gaetano; Grassi, Roberto; Gatta, Gianluca

    2014-12-18

    Peutz-Jeghers syndrome is an autosomal dominant disease with incomplete penetrance and variable expression caused by germline mutation of serine threonine kinase 11/liver kinase B1; it is characterized by hamartomatous polyps in the gastrointestinal tract, mucocutaneous melanin pigmentation, and increased predisposition to neoplasms. In Peutz-Jeghers syndrome, bilateral Sertoli cell testicular tumors cause endocrine manifestations including gynecomastia and feminization. This study aimed to assess the role of breast ultrasound in the evaluation of the effectiveness of an innovative surgical approach. This report presents a pair of European 9-year-old identical male twins with Peutz-Jeghers syndrome, bilateral prepubertal gynecomastia, and testicular multifocal calcifications. Both twins were treated with anastrozole for 2 years. After finishing treatment, both underwent subcutaneous mastectomy performed by the "modified" Webster technique. Breast examination and ultrasound were performed before and after the pharmacological and surgical treatment. A breast ultrasound scan before surgery showed bilateral gynecomastia in both patients. No solid nodular or cystic formations were present on either side. After pharmacological therapy and surgical glandular removal, a breast examination showed a significant reduction in breast volume; 1 year after surgery, a breast ultrasound scan of both patients showed a total absence of glandular parenchyma, with muscle planes well represented. Breast examination and ultrasound have proved to be a valid approach in the assessment of the treatment of prepubertal gynecomastia because they allow the efficacy of the pharmacological and surgical treatment to be evaluated in a multidisciplinary approach to one of the most frequent endocrine manifestations of Peutz-Jeghers syndrome.

  3. Solitary Peutz-Jeghers type hamartomatous polyps in the duodenum are not always associated with a low risk of cancer: two case reports

    Directory of Open Access Journals (Sweden)

    Koide Tomoko

    2011-06-01

    Full Text Available Abstract Introduction A hamartomatous polyp without associated mucocutaneous pigmentation or a family history of Peutz-Jeghers Syndrome is diagnosed as a solitary Peutz-Jeghers type hamartomatous polyp. As compared with Peutz-Jeghers Syndrome, Peutz-Jeghers type hamartomatous polyps are diagnosed with a lower risk of cancer and are regarded as a different disorder. Case presentation In case one, we describe an 84-year-old Japanese man with a 14 mm duodenal polyp. Endoscopic mucosal resection was performed and histological examination showed findings suggestive of a hamartomatous polyp with a focus of well-differentiated adenocarcinoma. In case two, we describe a 76-year-old Japanese man who had been treated for prostate, rectal and lung cancer. Upper gastrointestinal endoscopy revealed a duodenal polyp measuring 15 mm in diameter. Endoscopic mucosal resection was performed, and histological examination showed findings suggestive of a hamartomatous polyp. Liver and thyroid cancers were found after the endoscopic treatment. Conclusion Although duodenal solitary hamartomatous polyps are associated with a lower risk of cancer, four patients, including our cases, have been diagnosed with cancerous polyps. Patients with duodenal solitary hamartomatous polyps should be treated by endoscopic or surgical resection and need whole-body screening.

  4. Recurrent small intestine intussusception in a patient with Peutz-Jeghers syndrome Invaginación recurrente del intestino delgado en un paciente con síndrome de Pentz-Jeghers

    Directory of Open Access Journals (Sweden)

    Orestis Ioannidis

    2012-01-01

    Full Text Available Peutz-Jeghers syndrome is a rare hereditary autosomal dominant disease caused by a mutation of the tumor suppressor gene serine/threonine kinase 11 located in chromosome 19p13.3. It is characterized by the presence of extensive mucocutaneous pigmentation, especially of the lips and the occurrence of hamartomatous polyps throughout the gastrointestinal tract. Gastrointestinal hamartomas occur predominantly in the small intestine and can become symptomatic leading usually to intestinal obstruction and abdominal pain. We present a case of recurrent intestinal obstruction caused by small bowel intussusception treated by reduction, enterotomy and polypectomy and followed by intraoperative enteroscopy and endoscopic polypectomy.

  5. Peutz-Jeghers Syndrome: In Siblings with Palmer-Plantar Pigmentation

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    K V Suresh

    2011-01-01

    We report two unique cases of Peutz-Jeghers syndrome in sibling with intestinal polyposis and mucocutaneous pigmentation with a definite family history. An overview on differential diagnosis and therapeutic aspects of the disease has been discussed.

  6. Genetics Home Reference: Peutz-Jeghers syndrome

    Science.gov (United States)

    ... Patient Support and Advocacy Resources (2 links) American Cancer Society National Organization for Rare ... Beggs AD, Latchford AR, Vasen HF, Moslein G, Alonso A, Aretz S, Bertario L, Blanco I, Bülow S, Burn J, Capella G, Colas C, Friedl W, Møller P, Hes FJ, Järvinen ...

  7. Genetic and epigenetic profiling of a solitary Peutz-Jeghers colon polyp.

    Science.gov (United States)

    Linhart, Heinz; Bormann, Felix; Hutter, Barbara; Brors, Benedikt; Lyko, Frank

    2017-05-01

    Colon polyps represent precursor lesions of colon cancers and their malignant potential varies according to histological subtype. A rare subtype of colon polyps is the Peutz-Jeghers (PJ) polyp. PJ polyps mostly occur in the context of Peutz-Jeghers syndrome, which is characterized by the development of multiple polyps in the intestinal tract and hyperpigmentation of oral mucosa and lips. Peutz-Jeghers is an autosomal dominant disorder caused by pathogenic variants of the serine threonine kinase STK11. PJ polyps very rarely occur outside of the syndrome and are then referred to as solitary PJ polyps. Contrary to the situation in Peutz-Jeghers, the genetic basis and the malignant potential of solitary PJ polyps are currently unknown. Here we describe a detailed and comprehensive genetic profile of a solitary PJ polyp. Pathological examination revealed a high tissue homogeneity with >80% epithelial cells. Whole-genome sequencing failed to identify any clonal mutations but demonstrated a significant number of subclonal mutations. No somatic or germline mutations were found at the STK11 locus, suggesting that solitary PJ polyps are genetically distinct from Peutz-Jeghers polyps. In addition, methylome analysis revealed global hypomethylation and CpG island hypermethylation, two features that have been described as hallmarks of the colorectal cancer epigenome. These results provide an example of a premalignant lesion that is defined by epigenetic, rather than genetic changes. Furthermore, our findings support the notion that solitary PJ polyps constitute neoplastic tissue with malignant potential that should be removed for cancer prevention.

  8. Peutz--Jeghers syndrome with pseudoinvasion of hamartomatous polyps and multiple epithelial neoplasms.

    Science.gov (United States)

    Bolwell, J S; James, P D

    1979-01-01

    The risk of malignant change developing in the hamartomatous polyps in Peutz-Jeghers syndrome is widely held to be negligible. However an association with tumours of the upper gastro-intestinal tract, ovary and other diverse multiple neoplasms is now recognized. Previously reported cases of malignant change in Peutz--Jeghers polyps may represent 'pseudoinvasion' and we report such a case. This was associated with carcinomas of the bile ducts, left tonsil and a papillary adenoma of the pancreatic duct. It lends further support to the view that there may be a genetic predisposition to the development of neoplasms in this condition. Pathologists and clinicians must be aware of this entity of 'pseudoinvasion' in order to avoid unnecessarily radical surgery in Peutz-Jeghers syndrome.

  9. A 16-Year-Old Female with Peutz-Jeghers Syndrome

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    Mufti Munsurar Rahman

    2014-09-01

    Full Text Available Peutz-Jeghers syndrome is a rare autosomal dominant disorder of hamartomatous polyposis of the gastrointestinal tract, with pigmentation around lips and macules on the buccal mucosa that typically manifests itself as recurrent colicky abdominal pain and intestinal obstruction due to intussusception. Here we report a case of a 16-year-old girl who presented with abdominal pain, vomiting and previous history of laparotomy for intussusception. Multiple well demarcated black pigmented macules on lips, perioral region, buccal mucosa, digits, palms and soles were noted. She was diagnosed as a case of Peutz-Jeghers syndrome and managed conservatively.

  10. Peutz-Jeghers Syndrome in Children: High Recurrence Rate in Short-term Follow-up

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    Tomoaki Taguchi

    2003-10-01

    Full Text Available We have managed four cases of Peutz-Jeghers syndrome (PJS in children. Fathers of three of these patients had PJS. There was also a family history of cancer in three cases, with pancreatic cancer in a father, colonic and laryngeal cancers in a grandfather, and hepatic and gastric cancers in a grandmother. It is presumed that in each of the cases, the largest polyp was responsible for initial symptoms. Preoperative examination revealed additional small polyps in the whole alimentary tract except for the oesophagus. Patients underwent laparotomy to remove the largest polyps and subsequent intraoperative endoscopic polypectomy for other small polyps, to minimize intestinal resection. Follow-up gastrointestinal examinations, including upper gastrointestinal series, small intestinal contrast study, and barium enema, were repeated about once a year. Three of four cases showed recurrent small intestinal polyps, and one required a second laparotomy because of recurrent abdominal pain. In conclusion, patients with PJS occurring in childhood have a strong hereditary family history of cancer and a high incidence of recurrence. Careful follow-up examination is mandatory for the gastrointestinal tract, as well as other solid organs that are susceptible to malignant change, throughout a patient's life.

  11. Clinical characteristics and STK11 gene mutations in Chinese children with Peutz-Jeghers syndrome.

    Science.gov (United States)

    Huang, Zhiheng; Miao, Shijian; Wang, Lin; Zhang, Ping; Wu, Bingbing; Wu, Jie; Huang, Ying

    2015-11-25

    Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disease characterized by gastrointestinal hamartomatous polyps and mucocutaneous melanin spots. Germline mutation of the serine/threonine kinase 11 (STK11) gene are responsible for PJS. In this study, we investigated the clinical characteristics and molecular basis of the disease in Chinese children with PJS. Thirteen children diagnosed with PJS in our hospital were enrolled in this study from 2011 to 2015, and their clinical data on polyp characteristics, intussusceptions events, family histories, etc. were described. Genomic DNA was extracted from whole-blood samples from each subject, and the entire coding sequence of the STK11 gene was amplified by polymerase chain reaction and analyzed by direct sequencing. The median age at the onset of symptoms was 2 years and 4 months. To date, these children have undergone 40 endoscopy screenings, 17 laparotomies and 9 intussusceptions. Polyps were found in the stomach, duodenum, small bowel, colon and rectum, with large polyps found in 7 children. Mutations were found in eleven children, including seven novel mutations (c.481het_dupA, c.943_944het_delCCinsG, c.397het_delG, c.862 + 1G > G/A, c.348_349het_delGT, and c.803_804het_delGGinsC and c.121_139de l19insTT) and four previously reported mutations (c.658C > C/T, c.890G > G/A, c.1062 C > C/G, and c.290 + 1G > G/A). One PJS patient did not have any STK11 mutations. The polyps caused significant clinical consequences in children with PJS, and mutations of the STK11 gene are generally the cause of PJS in Chinese children. This study expands the spectrum of known STK11 gene mutations.

  12. INTUSSUSCEPTION IN A CASE OF PEUTZ JEGHER SYNDROME: A CASE REPORT

    OpenAIRE

    Manmadh Rao; Babji; Mahalakshmi D; Sankarao

    2015-01-01

    PeutzJegher syndrome is a rare disorder characterized by mucocutaneous melanin deposits over lips, oral mucosa, fingers and multiple hamartomatous polyps in gastrointestinal tract. These individuals may present with small intestinal intussusception with th ese polyp as lead point. We report a case of 15 year old boy presenting with intestinal obstruction with oral melanin deposits and found to have multiple hamartomatous polyps in small intestine

  13. Peutz-Jeghers syndrome and family planning: the attitude towards prenatal diagnosis and pre-implantation genetic diagnosis.

    Science.gov (United States)

    van Lier, Margot G F; Korsse, Susanne E; Mathus-Vliegen, Elisabeth M H; Kuipers, Ernst J; van den Ouweland, Ans M W; Vanheusden, Kathleen; van Leerdam, Monique E; Wagner, Anja

    2012-02-01

    Peutz-Jeghers syndrome (PJS) is a hereditary disorder caused by LKB1 gene mutations, and is associated with considerable morbidity and decreased life expectancy. This study was conducted to assess the attitude of PJS patients towards family planning, prenatal diagnosis (PND) and pregnancy termination, and pre-implantation genetic diagnosis (PGD). In a cross-sectional study, 61 adult PJS patients were asked to complete a questionnaire concerning genetic testing, family planning, PND and PGD. The questionnaire was completed by 52 patients (85% response rate, 44% males) with a median age of 44 (range 18-74) years. A total of 37 (71%) respondents had undergone genetic testing. In all, 24 respondents (46%, 75% males) had children. A total of 15 (29%) respondents reported that their diagnosis of PJS had influenced their decisions regarding family planning, including 10 patients (19%, 9/10 females) who did not want to have children because of their disease. Termination of pregnancy after PND in case of a foetus with PJS was considered 'acceptable' for 15% of the respondents, whereas 52% considered PGD acceptable. In conclusion, the diagnosis of PJS influences the decisions regarding family planning in one third of PJS patients, especially in women. Most patients have a negative attitude towards pregnancy termination after PND, while PGD in case of PJS is judged more acceptable. These results emphasise the importance of discussing aspects regarding family planning with PJS patients, including PND and PGD.

  14. Management of duodenal-jejunal polyps in children with peutz-jeghers syndrome with single-balloon enteroscopy.

    Science.gov (United States)

    Bizzarri, Barbara; Borrelli, Osvaldo; de'Angelis, Nicola; Ghiselli, Alessia; Nervi, Giorgio; Manfredi, Marco; de'Angelis, Gian Luigi

    2014-07-01

    Children with Peutz-Jeghers syndrome (PJS) have increased risk of polyp-related complications and emergency laparotomies. The aim of the present study was to assess the efficacy and the safety of endoscopic therapy of small bowel polyps using single-balloon enteroscopy (SBE) in children affected by PJS. Between January 2010 and December 2011, prospectively consecutive PJS children with polyps >15 mm or polyps actively bleeding previously identified using video capsule endoscopy and magnetic resonance imaging underwent therapeutic SBE. The main outcome measurements were the feasibility, the technical performance, and the safety. A total of 10 children (6 boys; median age 13.7 years, range 5.6-15.6) underwent 23 SBE procedures. Four patients had a history of abdominal surgery. A total of 53 polyps were removed, and 23 of them were >15 mm. The majority of polyps were found in jejunum (85%). The mean insertion depths for antegrade and retrograde approach were 200 ± 80 and 100 ± 50 cm beyond the ileal valve, respectively. The mean procedure time was 75 ± 25 minutes. Mild abdominal pain was reported after 3 procedures. In 1 patient a postpolypectomy perforation occurred. In conclusion, SBE is an effective endoscopic tool for treating small bowel polyps in children with PJS, and well-timed polypectomy may optimize patients' care, preventing polyp-related complications and emergency laparotomy. Further larger multicenter studies are warranted to accurately determine the safety of therapeutic SBE in children.

  15. Management of prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: from aromatase inhibitors to subcutaneous mastectomy.

    Science.gov (United States)

    Ferraro, Giuseppe Andrea; Romano, Tiziana; De Francesco, Francesco; Grandone, Anna; D'Andrea, Francesco; del Giudice, Emanuele Miraglia; Cataldo, Chiara; Gatta, Gianluca; Di Grezia, Graziella; Perrone, Laura; Nicoletti, Gianfranco

    2013-10-01

    Prepubertal gynecomastia is characterized by the presence of palpable uni- or bilateral breast tissue in boys without other signs of sexual maturation. It may be the endocrine expression of rare syndromes such as Peutz-Jeghers syndrome (PJS). This study aimed to evaluate the effectiveness of anastrozole and to describe an innovative surgical approach. This report presents twins with PJS, bilateral prepubertal gynecomastia, and testicular multifocal calcifications. Both twins were treated with anastrozole for 2 years. After finishing treatment, both were followed before subcutaneous mastectomy was performed by the "modified" Webster technique. Growth velocity decreased and gynecomastia diminished during anastrozole treatment. After discontinuation of therapy due to a sharp reduction in growth velocity, both twins showed regrowth of gynecomastia, with painful and strained breasts. A significant reduction in breast volume with glandular removal was achieved. The findings of this study showed a multidisciplinary approach to prepubertal gynecomastia due to the synergy of pediatricians, radiologists, and plastic surgeons. The follow-up evaluation after the anastrozole treatment showed it to be an efficacious medical treatment, as an alternative to orchidectomy, to control the effects of circulating estrogens. Moreover, the results observed in the patients confirmed the validity and feasibility of the "modified" Webster technique in terms of aesthetic and functional results, patient satisfaction, and absence of complications.

  16. Intussuscepção intestinal e oclusão intestinal causada por pólipos em intestino delgado na síndrome Peutz-Jeghers. Tratamento com ressecção por enterotomia associado a enteroscopia intra-operatória: relato de caso

    OpenAIRE

    Gama-Rodrigues, Joaquim J.; Silva, José Hyppolito da; Aisaka, Adilson A.; Jureidini, Ricardo; Falci Júnior, Renato; Maluf Filho, Fauze; Chong, A. Kim; Tsai, André Wan Wen; Bresciani, Cláudio

    2000-01-01

    The Peutz-Jeghers syndrome is a hereditary disease that requires frequent endoscopic and surgical intervention, leading to secondary complications such as short bowel syndrome. CASE REPORT: This paper reports on a 15-year-old male patient with a family history of the disease, who underwent surgery for treatment of an intestinal occlusion due to a small intestine intussusception. DISCUSSION: An intra-operative fiberscopic procedure was included for the detection and treatment of numerous polyp...

  17. Elevation of WNT5A expression in polyp formation in Lkb1+/- mice and Peutz-Jeghers syndrome.

    Science.gov (United States)

    Lai, Cecilia; Robinson, James; Clark, Sue; Stamp, Gordon; Poulsom, Richard; Silver, Andrew

    2011-04-01

    Peutz-Jeghers syndrome (PJS) is a rare, inherited disease caused by germline mutation of the LKB1 gene. Patients with PJS develop characteristic polyps in the digestive tract and carry an elevated risk of cancers in multiple organs, including the intestinal tract. While LKB1 is capable of phosphorylating AMPK and regulates the mTOR pathway, it is also known to be a multitasking protein that can influence other cellular processes, including cell polarity. We hypothesized that there may be other biological pathways directly or indirectly affected by the loss of LKB1 in PJS and aimed to investigate this possibility through transcriptional profiling of polyps harvested from an Lkb1(+/-) mouse model of PJS and from PJS patients. We identified alterations in the mRNA level of a wide range of genes, including some that are involved in Wnt signalling (Wnt5a, Wif1, Dixdc1, Wnt11, Ccnd1, and Ccnd2), although we did not observe nuclear localization of β-catenin in over 93 human PJS intestinal polyps or in 24 gastric polyps from Lkb1(+/-) mice. Among these genes, WNT5A, a non-canonical and non-transforming Wnt, is consistently up-regulated in both Lkb1(+/-) mice and human PJS polyps at a high level. We performed in situ hybridization to further define the spatial expression pattern of WNT5A and observed a strong signal in the stroma of mouse and human polyps compared to no or very low expression in the mucosa. Our findings indicate that WNT5A plays an important role in PJS polyposis. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  18. Response to Anastrozole Treatment in a Case with Peutz-Jeghers Syndrome and a Large Cell Calcifying Sertoli Cell Tumor.

    Science.gov (United States)

    Koç Yekedüz, Merve; Şıklar, Zeynep; Burgu, Berk; Kuloğlu, Zarife; Kocaay, Pınar; Çamtosun, Emine; İsakoca, Mehmet; Kansu, Aydan; Soygür, Tarkan; Berberoğlu, Merih

    2017-06-01

    Peutz-Jeghers syndrome (PJS) is inherited as an autosomal dominant trait characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of neoplasm. Large-cell calcifying Sertoli cell tumor (LCCSCT) is a kind of sex cord-stromal tumor which may co-exist with PJS and which is characterized radiologically by calcification foci within the testes. Surgical treatment options for this tumor range from testis-preserving surgery to radical orchiectomy. Not with standing this invasive approach, recently, there are some case reports demonstrating the efficacy of aromatase inhibitors in avoiding orchiectomy and its associated complications. In this paper, we have presented a LCCSCT case diagnosed in a boy with PJS and his response to anastrozole treatment.

  19. A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.

    Science.gov (United States)

    Zhao, Zi-Ye; Jiang, Yu-Liang; Li, Bai-Rong; Yang, Fu; Li, Jing; Jin, Xiao-Wei; Sun, Shu-Han; Ning, Shou-Bin

    2017-12-01

    Peutz-Jeghers syndrome (PJS) is a Mendelian autosomal dominant disease caused by mutations in the tumor suppressor gene, serine/threonine kinase 11 (STK11). The features of this syndrome include gastrointestinal (GI) hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer. Early onset of disease is often characterized by mucocutaneous pigmentation and intussusception due to GI polyps in childhood. A girl with a positive family history grew oral pigmentation at 1 and got intussusception by small bowel hamartomas at 5. She was diagnosed with PJS based on oral pigmentation and a positive family history of PJS. Enteroscopy was employed to treat the GI polyps. Sanger sequencing was used to investigate STK11 mutation in this family. A large jejunal polyp together with other smaller ones was resected, and the girl recovered uneventfully. We discovered a heterozygous substitution in STK11, c.A527G in exon 4, in the girl and her father who was also a PJS patient, and the amine acid change was an aspartic acid-glycine substitution in codon 176. This mutation was not found in other healthy family members and 50 unrelated non-PJS controls, and it is not recorded in databases, which prove it a novel mutation. Evolutionary conservation analysis of amino acid residues showed this aspartic acid is a conserved one between species, and protein structure prediction by SWISS-MODEL indicated an obvious change in local structure. In addition, PolyPhen-2 score for this mutation is 1, which indicates it probably damaging. PJS can cause severe complication like intussusception in young children, and early screening for small bowel may be beneficial for these patients. The mutation of STK11 found in this girl is a novel one, which enlarges the spectrum of STK11. Our analysis supported it a causative one in PJS.

  20. Intestinal intussusception and occlusion caused by small bowel polyps in the Peutz-Jeghers syndrome. Management by combined intraoperative enteroscopy and resection through minimal enterostomy: case report Intussuscepção intestinal e oclusão intestinal causada por pólipos em intestino delgado na síndrome Peutz-Jeghers. Tratamento com ressecção por enterotomia associado a enteroscopia intra-operatória: relato de caso

    Directory of Open Access Journals (Sweden)

    Joaquim J. Gama-Rodrigues

    2000-12-01

    Full Text Available The Peutz-Jeghers syndrome is a hereditary disease that requires frequent endoscopic and surgical intervention, leading to secondary complications such as short bowel syndrome. CASE REPORT: This paper reports on a 15-year-old male patient with a family history of the disease, who underwent surgery for treatment of an intestinal occlusion due to a small intestine intussusception. DISCUSSION: An intra-operative fiberscopic procedure was included for the detection and treatment of numerous polyps distributed along the small intestine. Enterotomy was performed to treat only the larger polyps, therefore limiting the intestinal resection to smaller segments. The postoperative follow-up was uneventful. CONCLUSION: We point out the importance of conservative treatment for patients with this syndrome, especially those who will undergo repeated surgical interventions because of clinical manifestation while they are still young.A síndrome de Peutz-Jeghers é uma doença de caráter hereditário que freqüentemente requer intervenções endoscópicas e cirúrgicas repetidas, levando a complicações secundárias como, por exemplo, a síndrome do intestino curto. RELATO DE CASO: Relatamos neste artigo o caso de paciente de 15 anos, masculino, com história familiar para a doença, que foi submetido ao procedimento cirúrgico para tratar oclusão devido a intussucepção de intestino delgado. DISCUSSÃO: Associou-se método fibroscópico intra-operatório com a finalidade de detecção e ressecção de numerosos pólipos distribuídos em todo o intestino delgado. Realizaram-se enterotomias para a retirada dos pólipos maiores, restringindo-se, portanto, a ressecção intestinal a segmentos menores. A evolução clínica foi boa. CONCLUSÃO: Ressalta-se a importância do manejo de forma conservadora dos pacientes portadores desta síndrome, principalmente naqueles cujas manifestações clínicas de importância cirúrgica aparecem precocemente.

  1. Management of Peutz-Jeghers syndrome. Experience with patients from the Danish Polyposis Register

    DEFF Research Database (Denmark)

    Rebsdorf Pedersen, I; Hartvigsen, A; Fischer Hansen, B

    1994-01-01

    rate are followed with few examinations. The programme includes upper and lower gastrointestinal endoscopy, small bowel enema and in cases with large or symptomatic polyps, laparotomy with intraoperative total enteroscopy with polypectomy as required. Pelvic examination, cervical smear, breast...

  2. Peutz-Jeghers syndrome.

    Science.gov (United States)

    Heymann, Warren R

    2007-09-01

    Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service to readers of the Journal of the American Academy of Dermatology.

  3. Feasibility of video capsule endoscopy in the management of children with Peutz-Jeghers syndrome: a blinded comparison with barium enterography for the detection of small bowel polyps.

    Science.gov (United States)

    Postgate, Aymer; Hyer, Warren; Phillips, Robin; Gupta, Arun; Burling, David; Bartram, Clive; Marshall, Michelle; Taylor, Stuart; Brown, Gregor; Schofield, Gill; Bassett, Paul; Spray, Christine; Fitzpatrick, Aine; Latchford, A; Fraser, Chris

    2009-10-01

    Peutz-Jeghers syndrome (PJS) in children may present with anaemia, intussusception, or obstruction from an early age and surgery is common. Prophylactic polypectomy may reduce subsequent complications. Traditional barium enterography (BE) has poor sensitivity and requires significant radiation. We compared the performance of capsule endoscopy (CE) with BE in children with PJS. Children with PJS (ages 6.0-16.5 years) were prospectively recruited and underwent BE followed by CE, each reported by expert reviewers blinded to the alternate modality. Number of "significant" (>10 mm) and total number of polyps were recorded. Child preference was assessed using a visual analogue questionnaire. Definitive findings were assessed at laparotomy or enteroscopy, when performed. There was no significant difference for >10 mm polyp detection. Six polyps were found in 3 children by both modalities: 3 polyps in 2 children at CE, 3 polyps in 1 child at BE (P=0.50). Re-review of 1 CE identified 3 polyps that were missed in 1 child at initial reading. Significantly more polyps were identified by CE than BE: 61 vs 6 (P=0.02). CE was significantly more comfortable than BE (median score CE 76 [interquartile range 69-87] vs BE 37 [interquartile range 31-68], P=0.03) and was the preferred investigation in 90% (P=0.02). CE is a feasible, safe, and sensitive test for small bowel polyp surveillance in children with PJS. It is significantly more comfortable than BE and is the preferred test of most children for future surveillance. There is a learning curve for reporting CE studies in PJS and appropriate training is essential.

  4. Peutz-Jeghers syndrome: case report | Igun | East African Medical ...

    African Journals Online (AJOL)

    She is being followed up for evidence of malignant transformation in associated intestinal polyps and development of extra-intestinal malignancies at other sites. The management of 1'JS in light of recent trends is discussed, especially with reference to suggested protocols for screening and surveillance of sites at supposed ...

  5. PeutzJeghers syndrome: A case report and literature review

    Directory of Open Access Journals (Sweden)

    A Lakhey

    2014-09-01

    Full Text Available Peutz–Jeghers Syndrome is an autosomal dominant inheritedhamartomatous polyp. We present a case of a 5-year-old young boywith a history of per rectal bleeding and mass protruding out of the anus. Physical examination revealed presence of mucocutaneous pigmented lesions over the tongue, and few hamartomatous polyps protruding out of the rectum suggesting Peutz–Jeghers syndrome. The presence in early infancy of small, well-demarcated and dark-brown to blue-black lentigines on the lips,buccal mucosa and perioral skin, should alert the clinician to Peutz–Jeghers Syndrome.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11597 Journal of Pathology of Nepal; Vol.4,No. 8 (2014 677-679

  6. A Rare Cause of Prepubertal Gynecomastia: Sertoli Cell Tumor

    Directory of Open Access Journals (Sweden)

    Fatma Dursun

    2015-01-01

    Full Text Available Prepubertal gynecomastia due to testis tumors is a very rare condition. Nearly 5% of the patients with testicular mass present with gynecomastia. Sertoli cell tumors are sporadic in 60% of the reported cases, while the remaining is a component of multiple neoplasia syndromes such as Peutz-Jeghers syndrome and Carney complex. We present a 4-year-old boy with gynecomastia due to Sertoli cell tumor with no evidence of Peutz-Jeghers syndrome or Carney complex.

  7. The patient with multiple intestinal polyps.

    Science.gov (United States)

    Schulmann, Karsten; Pox, Christian; Tannapfel, Andrea; Schmiegel, Wolff

    2007-01-01

    The management of patients with multiple intestinal polyps may be difficult and greatly depends on the correct classification. Polyposis syndromes account for less than 1% of newly diagnosed colorectal cancers. In addition the risk for extracolonic cancer is increased in most syndromes. Here we report the case of a difficult patient with severe gastric polyposis and we present a review of polyposis syndromes such as classical and attenuated familial adenomatous polyposis (FAP), MYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis as well as rare polyposis syndromes. The most practical approach for the diagnostic workup in patients with newly diagnosed gastrointestinal polyposis is based on the histological typing of polyps. In addition, a detailed family history regarding cancer, polyps and congenital abnormalities should be obtained from every polyposis patient. Patients with multiple adenomas are most likely to suffer from FAP, AFAP or MAP. Of these, younger age and higher polyp count are most likely a diagnosis of typical FAP. Older age and fewer polyps favour a diagnosis of AFAP or MAP. Germline testing of the APC gene is suggested, and if negative, MYH gene testing should be done. In patients with hamartomas, extraintestinal features should be evaluated and reference histology should be initiated. In addition panintestinal imaging should be performed with EGD, colonoscopy and small bowel imaging (PE, CE, and MR) enteroclysis. For diagnostic and therapeutic problems a familial colorectal cancer center should be consulted. Using this algorithm, correct classification and adequate treatment should be possible for every polyposis patient.

  8. Czech

    Czech Academy of Sciences Publication Activity Database

    Čmejrková, Světla; Daneš, F.

    2010-01-01

    Roč. 88, č. 3 (2010), s. 669-692 ISSN 0035-0818 R&D Projects: GA ČR GA405/09/2028 Institutional research plan: CEZ:AV0Z90610518 Keywords : Czech * development * identity * grammar * language contact * ethnonym Subject RIV: AI - Linguistics

  9. PEUTZ-JEGHERS SYNDROME: CASE REPORT G.O. IGUN, Y.Y. ...

    African Journals Online (AJOL)

    1999-05-05

    May 5, 1999 ... followed up for evidence of malignant transformation in associated intestinal polyps and ... intestinal cancers. A11 these facts call for a review into the cause, clinical features, natural history, management and surveillance programmes that form the .... and polytectomy is required for diagnosis and treatment.

  10. Case Report - Syndrome de Peutz-Jeghers, à propos de 3 cas dans ...

    African Journals Online (AJOL)

    Le gène de PJS a été localisé sur le chromosome 19p13.13. Les signes cutanés sont affichants et constituent un signe révélateur de la maladie, ils sont à type de lentigines, Ils siègent le plus souvent sur les lèvres, la muqueuse buccale. Les polypes digestifs constituent le deuxième signe cardinal de ce syndrome et ils ...

  11. Feasibility and diagnostic utility of video capsule endoscopy for the detection of small bowel polyps in patients with hereditary polyposis syndromes.

    Science.gov (United States)

    Schulmann, Karsten; Hollerbach, Stephan; Kraus, Katja; Willert, Jörg; Vogel, Tilman; Möslein, Gabriela; Pox, Christian; Reiser, Markus; Reinacher-Schick, Anke; Schmiegel, Wolff

    2005-01-01

    At present, surveillance of premalignant small bowel polyps in hereditary polyposis syndromes has a number of limitations. Capsule endoscopy (CE) is a promising new method to endoscopically assess the entire length of the small bowel. We prospectively examined 40 patients with hereditary polyposis syndromes (29 familial adenomatous polyposis (FAP), 11 Peutz-Jeghers syndrome (PJS)). Results were compared with push-enteroscopy (PE) results in FAP and with esophagogastroduodenoscopy, PE, (MR)-enteroclysis, and surgical specimen in PJS patients. A total of 76% of the patients with FAP with duodenal adenomas (n = 21) had additional adenomas in the proximal jejunum that could be detected by CE and PE. Moreover, 24% of these FAP patients had further polyps in the distal jejunum or ileum that could only be detected by CE. In contrast, in FAP patients without duodenal polyps (n = 8), jejunal or ileal polyps occurred rarely (12%). CE detected polyps in 10 of 11 patients with PJS, a rate superior to all other reference procedures employed. Importantly, the findings of CE had immediate impact on further clinical management in all PJS patients. Our results suggest that CE may be of clinical value in selected patients with FAP, whereas in PJS, CE could be used as first line surveillance procedure.

  12. Polyps in children.

    Science.gov (United States)

    Adolph, Vincent R; Bernabe, Kathryn

    2008-11-01

    Children with polyps usually present with bleeding or pain. Most pediatric intestinal polyps are sporadic and are not associated with malignancy. Polyposis syndromes are also well described in children. Peutz-Jeghers syndrome is the most common hamartomatous polyposis condition. Although the polyps are not thought to be premalignant in most patients, there is an increased risk of other cancers. Familial adenomatous polyposis is also seen in childhood and is associated with a very high risk of malignant transformation as well as extracolonic adenomas and malignancy. The diagnosis and management of sporadic juvenile polyps, Peutz-Jeghers syndrome, and familial adenomatous polyposis, as well as rarer conditions associated with intestinal polyps are reviewed in this article.

  13. Patient skin dosimetry in interventional cardiology in the Czech Republic

    International Nuclear Information System (INIS)

    Sukupova, L.; Novak, L.; Kala, P.; Cervinka, P.; Stasek, J.

    2011-01-01

    In this study, skin dosimetry of patients undergoing interventional cardiology procedures is presented. Three hospitals were included. Two methods were used for skin dosimetry-radiochromic dosimetry films and reconstruction of skin dose distribution based on examination protocol. Maximum skin doses (MSD) obtained from both methods were compared for 175 patients. For patients for whom the film MSD was >1 Gy, the reconstruction MSD differed from the film MSD in the range of ± 50 % for 83 % of patients. For remaining patients, the difference was higher and it was caused by longer fluoroscopy time. For 59 patients for whom the cumulative dose was known, the cumulative dose was compared with the film MSD. Skin dosimetry with radiochromic films is more accurate than the reconstruction method, but films do not include X-ray fields from lateral projections whilst reconstructions do. (authors)

  14. [Monitoring of diabetes compensation in patients treated with an insulin pump in the Czech Republic].

    Science.gov (United States)

    Rušavý, Zdeněk; Honěk, Petr; Dušek, Ladislav; Pavlík, Tomáš; Žďarská, Denisa Janíčková; Kvapil, Milan

    2015-11-01

    Insulin pump treatment (IP) is one of the ways of intensive insulin therapy, designed preferentially for patients with type 1 diabetes. The price of the treatment is higher than that of the conventional basalbolus and insulin regimens using repeated insulin application with a dose selector. Quality assessment of IP therapy monitoring in patients with DM in a representative sample of the patient population with DM kept in the database of the General Health Insurance Company of the Czech Republic (VZP) which provided health care coverage for 63% of Czech population in 2014. We identified all individuals in the VZP database who had a record of DM diagnosis (E10-E16 based on ICD 10) or who had any antidiabetic therapy prescribed (ATC group A10) in the period of 2009-2013. Over the whole period of 2009-2014 there were overall n=4,002 unique patients with DM identified in the VZP data, who were treated with IP within the assessment period. Incidence for the year 2014 (the newly treated with an insulin pump): all patients who had IP recorded in 2014 while in the preceding period of 2009-2013 they had no record of IP use. Prevalence for the year 2014 (all treated with an insulin pump): all the patients who for the period of 2010-2014 had at least once insulin pump use recorded and who did not die before 2014. Quality control parameters (HbA1c examination and consumption of glucose level test strips) for patients treated with IP were only assessed in detail for the year 2014, namely for all patients undergoing insulin pump treatment in 2014 throughout the year (i.e. from 1 January 2014 to 31 December 2014), i.e. in n=3,189 patients in all. In 2014 there were 247 incident patients and 3 794 prevalent patients. IP was newly introduced for almost 50% of the patients aged 20-39 years. In 2014 an average frequency of HbA1c examination equaled 3.38 per patient and 98.5% patients were examined for HbA1c at least once. An average consumption of glucose level testing strips per

  15. RET variants and haplotype analysis in a cohort of Czech patients with Hirschsprung disease.

    Directory of Open Access Journals (Sweden)

    Eliska Vaclavikova

    Full Text Available Hirschsprung disease (HSCR is a congenital aganglionosis of myenteric and submucosal plexuses in variable length of the intestine. This study investigated the influence and a possible modifying function of RET proto-oncogene's single nucleotide polymorphisms (SNPs and haplotypes in the development and phenotype of the disease in Czech patients. Genotyping of 14 SNPs was performed using TaqMan Genotyping Assays and direct sequencing. The frequencies of SNPs and generated haplotypes were statistically evaluated using chi-square test and the association with the risk of HSCR was estimated by odds ratio. SNP analysis revealed significant differences in frequencies of 11 polymorphic RET variants between 162 HSCR patients and 205 unaffected controls. Particularly variant alleles of rs1864410, rs2435357, rs2506004 (intron 1, rs1800858 (exon 2, rs1800861 (exon 13, and rs2565200 (intron 19 were strongly associated with increased risk of HSCR (p<0.00000 and were over-represented in males vs. females. Conversely, variant alleles of rs1800860, rs1799939 and rs1800863 (exons 7, 11, 15 had a protective role. The haploblock comprising variants in intron 1 and exon 2 was constructed. It represented a high risk of HSCR, however, the influence of other variants was also found after pruning from effect of this haploblock. Clustering patients according to genotype status in haploblock revealed a strong co-segregation with several SNPs and pointed out the differences between long and short form of HSCR. This study involved a large number of SNPs along the entire RET proto-oncogene with demonstration of their risk/protective role also in haplotype and diplotype analysis in the Czech population. The influence of some variant alleles on the aggressiveness of the disease and their role in gender manifestation differences was found. These data contribute to worldwide knowledge of the genetics of HSCR.

  16. Measuring preoperative anxiety in patients undergoing elective surgery in Czech Republic

    Directory of Open Access Journals (Sweden)

    Pavlína Homzová

    2015-12-01

    Full Text Available Aim: The main aim of the study was to measure preoperative anxiety in patients in the Czech Republic before elective surgery, using the Visual Analogue Scale for Anxiety (VAS-A. Design: A cross-sectional descriptive study. Methods: The sample consisted of 344 patients undergoing elective surgery. The day before surgery patients completed a questionnaire consisting of demographic data, the Amsterdam Preoperative Anxiety and Information Scale (APAIS and the VAS-A. Spearman correlation was used to test correlation between the VAS-A and the subscales of the APAIS. Analysis of Variance (ANOVA and the Kruskal-Walis test were used for group comparison. A p-value < 0.05 was considered to be significant. Results: Female patients and patients without previous experience of surgery had a significantly higher VAS-A score. The anxiety score measured by the VAS-A positively correlated with APAIS-Anxiety (r = 0.71 and its subscales. The results also showed that the most common anxieties resulted from postoperative pain, anaesthesiological complications, postoperative nausea and vomiting, concerns about regaining consciousness after anaesthesia, surgical errors, and postponement of surgery. Conclusion: The findings of this study support the utility of the VAS-A as a measure of preoperative anxiety. The VAS-A quickly and simply assesses anxiety and may be useful for research as well as clinical purposes when researchers or clinicians have very limited time.

  17. Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients.

    Science.gov (United States)

    Vymetalkova, Veronika Polakova; Slyskova, Jana; Korenkova, Vlasta; Bielik, Ludovit; Langerova, Lucie; Prochazka, Pavel; Rejhova, Alexandra; Schwarzova, Lucie; Pardini, Barbara; Naccarati, Alessio; Vodicka, Pavel

    2014-01-31

    Mismatch repair (MMR) genes are known to be frequently altered in colorectal cancer (CRC). Both genetics and epigenetics modifications seems to be relevant in this phenomenon, however it is still not clear how these two aspects are interconnected. The present study aimed at characterizing of epigenetic and gene expression profiles of MMR genes in sporadic CRC patients from the Czech Republic, a country with one of the highest incidences of this cancer all over Europe. Expression levels and CpG promoter methylation status of all MMR genes were evaluated in DNA from tumor and adjacent mucosal samples of 53 incident CRC patients. We have found significantly increased transcription levels in EXO1 gene in tumor tissues (P = 0.05) and significant over-expression of MSH3 gene in colon tumors when compared to adjacent mucosal tissues (P = 0.02). Interestingly, almost all MMR genes were differently expressed when localization of tumors was compared. In particular, colon tumors showed an up-regulation of EXO1, MSH2, MSH3, MSH6, and PMS2 genes in comparison to rectal tumors (P = 0.02). Expression levels of all MMR genes positively correlated between each other. The promoter methylation of MLH1 gene was observed in 9% of CRC tissues only. In our study, we have observed different pattern of MMR genes expression according to tumor localization. However, a lack of association between methylation in MMR genes and their corresponding expressions was noticed in this study, the relationship between these two aspects is worthy to be analyzed in larger population studies and in pre-malignant stages.

  18. COL1A2 gene analysis in a Czech osteogenesis imperfecta patient: a candidate novel mutation in a patient affected by osteogenesis imperfecta type 3

    Directory of Open Access Journals (Sweden)

    Hrušková L

    2015-08-01

    Full Text Available Lucie Hrušková,1 Ivo Mařík,2,3 Stella Mazurová,1 Pavel Martásek,1 Ivan Mazura1 1Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; 2Ambulant Centre for Defects of Locomotor Apparatus 1.1.c., Prague, Czech Republic; 3Faculty of Medical Studies, West Bohemia University, Pilsen, Czech RepublicAbstract: Osteogenesis imperfecta is a heritable bone fragility disease with a heterogenic genetic origin. Most cases result from mutations of either the COL1A1 gene or the COL1A2 gene. We identified a novel COL1A2 gene mutation in a Czech patient, born to unaffected parents, who was diagnosed according to clinical and anthropometric findings and radiographic features as having type 3 osteogenesis imperfecta, which is a severe form of this disease. The identified Gly814Trp mutation was predicted by a number of complementary bioinformatic programs to result in functional alteration of the protein. This case report provides both evidence of a novel COL1A2 mutation resulting in type 3 osteogenesis imperfecta and a genotype:phenotype correlation in this affected individual. Keywords: osteogenesis imperfecta type 3, collagen, alpha-2 (I chain, substitution, sequencing 

  19. Propositional Density in Spoken and Written Language of Czech-Speaking Patients with Mild Cognitive Impairment

    Science.gov (United States)

    Smolík, Filip; Stepankova, Hana; Vyhnálek, Martin; Nikolai, Tomáš; Horáková, Karolína; Matejka, Štepán

    2016-01-01

    Purpose Propositional density (PD) is a measure of content richness in language production that declines in normal aging and more profoundly in dementia. The present study aimed to develop a PD scoring system for Czech and use it to compare PD in language productions of older people with amnestic mild cognitive impairment (aMCI) and control…

  20. Patient rights protection in the Czech Republic: challenges of a transition from Communism to a modern legal system.

    Science.gov (United States)

    Dostal, O

    2007-03-01

    The post-Communist countries in Central Europe, including the Czech Republic, underwent a rapid transformation of their legal systems, within which the concept of patient rights passed through revolutionary changes. This process however often left significant gaps in patient rights protection. There are practical difficulties for patients in defending their rights before the courts, such as problems with obtaining evidence and independent expert opinions, long delays and high costs of court proceedings, strict burden of proof rules and low compensation levels. Modern patient rights often collide with the systems of health care provision that are still unprepared for patient autonomy and responsibility. The experience gained in the transition process might be applicable also to other countries that undergo changes from traditional to modern system of patient rights protection.

  1. Estimating cancer incidence, prevalence, and the number of cancer patients treated with antitumor therapy in 2015 and 2020 -  analysis of the Czech National Cancer Registry.

    Science.gov (United States)

    Dusek, L; Pavlík, T; Májek, O; Büchler, T; Muzik, J; Maluskova, D; Koptíková, J; Bortlicek, Z; Abrahámová, J

    2015-01-01

    Cancer burden in the Czech population ranks among the highest worldwide, which introduces a strong need for a prospective modelling of cancer incidence and prevalence rates. Moreover, a prediction of number of cancer patients requiring active antitumor therapy is also an important issue. This paper presents the stage-specific predictions of cancer incidence and prevalence, and the stage- and region-specific patients requiring active antitumor therapy for the most common cancer diagnoses in the Czech Republic for years 2015 and 2020. The stage-specific estimates are also presented with regard to the treatment phase as newly diagnosed patients, patients treated for non-terminal recurrence, and patients treated for terminal recurrence. Data of the Czech National Cancer Registry from 1977 to 2011 has been used for the analysis, omitting the records of patients diagnosed as death certificate only or at autopsy. In total, 1,777,775 incidences have been considered for the estimation using a statistical model utilizing solely the population-based cancer registry data. All estimates have been calculated with respect to the changing demographic structure of the Czech population and the clinical stage at diagnosis. Considering year 2011 as the baseline, we predict 89%, 15%, 31% and 32% increase in prostate, colorectal, female breast and lung cancer incidence, respectively, in 2020 resulting in 13,153, 9,368, 8,695, and 8,604 newly dia-g--nosed cancer patients in that year, respectively. Regarding cancer prevalence in 2020, the estimated increase is 140%, 40%, 51%, and 17% for prostate, colorectal, female breast and lung cancer, respectively, meaning that more than 100,000 prevalent female breast cancer patients as well as more than 100,000 prevalent prostate cancer patients are expected in the Czech Republic. The estimated numbers of patients requiring active antitumor therapy for prostate, colorectal, female breast and lung cancer in the Czech Republic in 2020 are 23,652, 14

  2. Novel CDKL5 Mutations in Czech Patients with Phenotypes of Atypical Rett Syndrome and Early-Onset Epileptic Encephalopathy.

    Science.gov (United States)

    Záhoráková, D; Langová, M; Brožová, K; Laštůvková, J; Kalina, Z; Rennerová, L; Martásek, P

    2016-01-01

    The X-linked CDKL5 gene, which encodes cyclin-dependent kinase-like 5 protein, has been implicated in early-onset encephalopathy and atypical Rett syndrome with early-onset seizures. The CDKL5 protein is a kinase required for neuronal development and morphogenesis, but its precise functions are still largely unexplored. Individuals with CDKL5 mutations present with severe global developmental delay, intractable epilepsy, and Rett-like features. A clear genotype-phenotype correlation has not been established due to an insufficient number of reported cases. The aim of this study was to analyse the CDKL5 gene in Czech patients with early-onset seizures and Rett-like features. We performed mutation screening in a cohort of 83 individuals using high-resolution melting analysis, DNA sequencing and multiplex ligation- dependent probe amplification. Molecular analyses revealed heterozygous pathogenic mutations in three girls with severe intellectual disability and intractable epilepsy starting at the age of two months. All three identified mutations, c.637G>A, c.902_977+29del105, and c.1757_1758delCT, are novel, thus significantly extending the growing spectrum of known pathogenic CDKL5 sequence variants. Our results support the importance of genetic testing of the CDKL5 gene in patients with early-onset epileptic encephalopathy and Rett-like features with early-onset seizures. This is the first study referring to molecular defects of CDKL5 in Czech cases.

  3. Diagnosis and management of gastrointestinal polyps: pediatric considerations.

    Science.gov (United States)

    Attard, Thomas M; Young, Rosemary J

    2006-01-01

    Painless, bright red, rectal bleeding with normal stool frequency and consistency is the hallmark presentation of colorectal polyps at any age. Most polyps in children are sporadic, usually isolated, colorectal juvenile polyps that do not require any further surveillance after they are removed. There is, however, increasing recognition of syndromes, including familial adenomatous polyposis, juvenile polyposis coli, Peutz-Jeghers syndrome, and infrequent conditions, such as PTEN hamartoma and hereditary mixed polyposis syndromes. The aim of this review is to allow the reader to correctly identify the patients who do not require follow-up and the smaller group of patients who do require follow-up because of syndromic polyp conditions.

  4. Differentiated thyroid carcinoma and intestinal polyposis syndromes.

    Science.gov (United States)

    Triggiani, Vincenzo; Angelo Giagulli, Vito; Tafaro, Angela; Resta, Francesco; Sabba, Carlo; Licchelli, Brunella; Guastamacchia, Edoardo

    2012-12-01

    Familial Adenomatous Polyposis, Cowden's Syndrome, and Peutz-Jeghers Syndrome are well known as Intestinal Polyposis Syndromes, inherited conditions characterized by the development of polyps of the gastro-intestinal tract in association with extra-intestinal manifestations, in particular malignant tumors at different sites. Thyroid carcinoma is sometimes a part of the clinical picture of these syndromes. The aim of this paper is to review the literature dealing with the association between differentiated thyroid carcinomas and Intestinal Polyposis Syndromes in order to point out peculiar aspects, providing suggestions for the screening and the management of thyroid tumors in these patients.

  5. Czech feminism

    OpenAIRE

    Robinson, L. C.

    1980-01-01

    The development of the Czech feminist movement was inextricably linked with nationalism. Nationalist ideology recognised the power of women as mothers and their consequent claim to equality within the context of the nation. Having implicitly acknowledged the justice of feminism, nationalists then had to accommodate women's demands. As nationalism changed from a cultural to a political force, feminine patriotism slowly became a feminist movement. These links with nationali...

  6. A prospective trial comparing wireless capsule endoscopy and barium contrast series for small-bowel surveillance in hereditary GI polyposis syndromes.

    Science.gov (United States)

    Mata, Alfredo; Llach, Josep; Castells, Antoni; Rovira, Josep M; Pellisé, María; Ginès, Angels; Fernández-Esparrach, Gloria; Andreu, Montserrat; Bordas, Josep M; Piqué, Josep M

    2005-05-01

    Capsule endoscopy has demonstrated its clinical utility in the evaluation of the small bowel, and, accordingly, it has been suggested that it could be useful for the identification of small-intestinal polyps in patients with polyposis syndromes. The objective was to establish the effectiveness of wireless capsule endoscopy for detecting small-bowel polyps in patients with hereditary GI polyposis syndromes in comparison with barium contrast series. Consecutive patients with GI polyposis syndromes were included. Small-bowel follow-through series and capsule endoscopy were performed within 1 week, in a blind fashion. The number and the location of polyps were analyzed. Twenty-four patients with familial adenomatous polyposis (n = 20) or Peutz-Jeghers syndrome (n = 4) were included. Capsule endoscopy detected small-bowel polyps in 7 of 24 patients (29%), whereas a barium contrast study identified small-intestinal polyps in only 3 of these 7 patients. In the 4 remaining patients, all of them with familial adenomatous polyposis, polyps detected by the capsule but missed in radiographic series were located at either ileum (2 patients), jejunum (1), or duodenum (1). No procedure-related complication was observed in any patient. Wireless capsule endoscopy is a highly accurate technique for the detection of small-bowel polyps in patients with hereditary GI polyposis syndromes, and it represents a valuable alternative to barium contrast series in the surveillance of patients with Peutz-Jeghers syndrome.

  7. Common Czech vs colloquial Russian

    Directory of Open Access Journals (Sweden)

    Андрей Иванович Изотов

    2013-12-01

    Full Text Available In this paper, a phenomenon of Common Czech in respect to Standard Czech is regarded. Main features of Common Czech are described. Linguistic situation in Czech Republic is compared to the classical diglossia situation.

  8. Mystification in Czech cinematography and Czech culture

    Directory of Open Access Journals (Sweden)

    ANNA BRZEZIŃSKA

    2013-12-01

    Full Text Available The article concerns the issue of mystification and hoax in Czech culture. It demonstrates historical aspects of this phenomenon and, basing on the example of various cultural texts, shows that the mystification as a means of artistic expression is deeply rooted in Czech culture. Surrealistic and illogical themes that are characteristic for Czech humour are used by artists, especially filmmakers, in creating successive mystifications. The article examines films such as Oil Gobblers (1988, Year of Devil (2002, Czech Dream (2004, Jara Cimrman Lying, Sleeping (1983, in order to analyse the role of this phenomenon in both films that speak of mystification and the ones that are mystifications themselves.

  9. The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Mack, Hildegard I.D.; Munger, Karl, E-mail: kmunger@rics.bwh.harvard.edu

    2013-11-15

    Infection with high-risk human papillomaviruses is causally linked to cervical carcinogenesis. However, most lesions caused by high-risk HPV infections do not progress to cancer. Host cell mutations contribute to malignant progression but the molecular nature of such mutations is unknown. Based on a previous study that reported an association between liver kinase B1 (LKB1) tumor suppressor loss and poor outcome in cervical cancer, we sought to determine the molecular basis for this observation. LKB1-negative cervical and lung cancer cells were reconstituted with wild type or kinase defective LKB1 mutants and we examined the importance of LKB1 catalytic activity in known LKB1-regulated processes including inhibition of cell proliferation and elevated resistance to energy stress. Our studies revealed marked differences in the biological activities of two kinase defective LKB1 mutants in the various cell lines. Thus, our results suggest that LKB1 may be a cell-type specific tumor suppressor. - Highlights: • LKB1 is a tumor suppressor that is linked to Peutz-Jeghers syndrome. • Peutz-Jeghers syndrome patients have a high incidence of cervical cancer. • Cervical cancer is caused by HPV infections. • This study investigates LKB1 tumor suppressor activity in cervical cancer.

  10. IDH1/2 Mutation and MGMT Promoter Methylation - the Relevant Survival Predictors in Czech Patients with Brain Gliomas.

    Science.gov (United States)

    Kramář, F; Minárik, M; Benešová, L; Halková, T; Netuka, D; Bradáč, O; Beneš, V

    2016-01-01

    Gliomas are a heterogeneous group of tumours varying in prognosis, treatment approach, and overall survival. Recently, novel markers have been identified which are linked to patient prognosis and therapeutic response. Especially the mutation of the enzyme isocitrate dehydrogenase 1 or 2 (IDH1/2) gene and the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status seem to be the most important predictors of survival. From 2012 to 2015, 94 Czech patients with primary brain tumours were enrolled into the study. The IDH1/2 mutation was detected by denaturing capillary electrophores.The methylation status of the MGMT gene and other 46 genes was revealed by MS-MLPA. In all 94 patients, the clinical data were correlated with molecular markers by Kaplan-Meier analyses and Cox regression model. The MGMT promoter methylation status was established and compared to clinical data. In our study eight different probes were used to elucidate the MGMT methylation status; hypermethylation was proclaimed if four and more probes were positive. This 3 : 5 ratio was tested and confirmed by Kaplan-Meier and Cox analyses. The study confirmed the importance of the IDH1/2 mutation and hypermethylation of the MGMT gene promoter being present in tumour tissue. Both markers are independent positive survival predictors; in the Cox model the IDH hazard ratio was 0.10 and in the case of MGMT methylation it reached 0.32. The methylation analysis of the panel of additional 46 genes did not reveal any other significant epigenetic markers; none of the candidate genes have been confirmed in the Cox regression analyses as an independent prognostic factor.

  11. How General Practitioners and Their Patients Adhere to Osteoporosis Management: A Follow-Up Survey among Czech General Practitioners

    Directory of Open Access Journals (Sweden)

    Magda Vytrisalova

    2017-05-01

    Full Text Available Introduction: General practitioners (GPs are key participants in osteoporosis (OP management. The aim was to evaluate their adherence to lege artis management of the disease, potential barriers, and to discuss differences observed in comparison with the baseline survey carried out in 2007; the focus was on secondary prevention.Methods: On behalf of two professional associations, 2-round postal survey among randomly selected GPs (>1/4 of all Czech GPs was performed in 2014. The questionnaire covered areas concerning GP's role in the fight against OP, knowledge about OP, management of OP-related fractures, barriers to the management of OP, system- and patient-related in particular, and availability and use of information sources.Results: The overall questionnaire return rate was 37% (551 respondents; mean age of the respondents was 53 year (37% men. The GP's role in the treatment of OP was rated as essential in 28 and 37% of men and women, respectively (P = 0.012. The guideline for diagnosis and treatment of OP for GPs was considered accessible by 92% of respondents. As much as 60% of the respondents were adherent to the guideline, i.e., used it repeatedly. The knowledge of several risk factors was very good, however, recommended daily intake of calcium was stated correctly by only 41% of respondents, and daily intake of vitamin D by only 40%. Three quarters reported active steps after a fracture: referral to a specialist, life-style recommendations, prescription of calcium/vitamin D supplements. Half of the respondents focus on fall prevention. System-related barriers, such as lack of possibility to prescribe selected drugs (61% and financial limits set by health insurance company (44% were most frequently reported. Patient-related barriers were also common, patient's non-adherence (reported by 29% and patient's reluctance to go to a specialist (18%.Conclusion: GPs adhered to OP management more than in 2007. Knowledge of risk factors and

  12. LKB1 as the ghostwriter of crypt history

    NARCIS (Netherlands)

    Jansen, Marnix; Langeveld, Danielle; De Leng, Wendy W. J.; Milne, Anya N. A.; Giardiello, Francis M.; Offerhaus, G. Johan A.

    Familial cancer syndromes present rare insights into malignant tumor development. The molecular background of polyp formation and the cancer prone state in Peutz-Jeghers syndrome remain enigmatic to this day. Previously, we proposed that Peutz-Jeghers polyps are not pre-malignant lesions, but an

  13. The attitude of Czech dental patients to the use of rubber dam.

    Science.gov (United States)

    Kapitan, Martin; Hodacova, Lenka; Jagelska, Julie; Kaplan, Jiri; Ivancakova, Romana; Sustova, Zdenka

    2015-10-01

    The most frequent arguments against rubber dam are that patients generally do not like it and the prolonged time of treatment. However, according to several studies, the attitude of patients towards rubber dam is rather positive. To find out the attitudes of patients to treatment with rubber dam; to determine influence of the circumstances of treatment or factors about patients; and to establish a mean time needed for rubber dam placement. A questionnaire survey. Patients of general dental practitioners, university clinical specialists and undergraduate dental students. A total of 179 questionnaires were distributed, from which 150 were returned. The mean time needed for rubber dam placement was 4 min for students and dam. A total of 77% of patients indicated a higher level of comfort during treatment with rubber dam. A preference to the future rubber dam usage was indicated by 86% of patients. The preference to the further rubber dam usage was statistically significantly affected by the level of comfort during the treatment with rubber dam (P dam usage (P dam usage. The attitude of patients to rubber dam was rather positive in our study. The time needed for rubber dam application was rather short. © 2013 John Wiley & Sons Ltd.

  14. Point mutations in Czech DMD/BMD patients and their phenotypic outcome.

    Science.gov (United States)

    Sedlácková, Jana; Vondrácek, Petr; Hermanová, Markéta; Zámecník, Josef; Hrubá, Zuzana; Haberlová, Jana; Kraus, Josef; Maríková, Tat'ána; Hedvicáková, Petra; Vohánka, Stanislav; Fajkusová, Lenka

    2009-11-01

    Duchenne and Becker muscular dystrophies (DMD/BMD) are associated with mutations in the DMD gene. We determined the mutation status of 47 patients with dystrophinopathy without deletion or duplication in the DMD gene by screening performed by reverse transcription-PCR, protein truncation test, and DNA sequencing. We describe three patients with a mutation creating a premature termination codon (p.E55X, p.E1110X, and p.S3497PfsX2) but with a mild phenotype, which present three different ways of rescuing the DMD phenotype. In one patient we detected the insertion of a repetitive sequence AluYa5 in intron 56, which led to skipping of exon 57. Further, using quantitative analysis of DMD mRNA carrying various mutated alleles, we examine levels of mRNA degradation due to nonsense mediated mRNA decay. The quantity of dystrophin mRNA is different depending on the presence of a mutation leading to a premature termination codon, and position of the analysed mRNA region with respect to its 5' end or 3' end. Average relative amounts of DMD mRNAs carrying a premature termination codon is 48% and 17%, when using primers amplifying the 5' and 3' cDNA regions, respectively.

  15. [Realistic possibilities of using data sources in quality assessment of care of patients with diabetes in the Czech Republic: National Diabetes Information System].

    Science.gov (United States)

    Kvapil, Milan

    2015-11-01

    Diabetes mellitus is a serious health and economic problem of our time. Therapy is primarily perceived as prevention of the late complications of diabetes. Most pharmacoeconomic analyses state that the cost associated with the therapy of diabetes mellitus is largely spent on the therapy of its complications. The project of the National Diabetes Information System is based on the essential principle of automated collection of data which is available in digital form in the Czech Republic and which describes the quality and quantity of the care provided for patients with diabetes mellitus and its results. Benefits of the posited National Diabetes Information System embrace minimizing of selective loss of data, a comprehensive view of epidemiology, therapy and its results, possibility of following trends, inclusion of costs related to hospitalization and social benefits. Risks involve correct interpretation and a possible system error. If we succeeded in implementing such system in the Czech Republic, it would be the first fully automatic information system on such a comprehensive scale worldwide. The data describing the incidence and prevalence of diabetes mellitus, therapy structure, direct healthcare costs and induced costs of social payments is in the largest part available in digital form. This creates a basis for the foundation of the National Diabetes Information System which will allow for continuous quality assessment of care for patients with diabetes mellitus, including the related pharmacoeconomic and social impacts.

  16. Czech Republic [2015

    Czech Academy of Sciences Publication Activity Database

    Linek, Lukáš

    2015-01-01

    Roč. 54, č. 1 (2015), s. 78-85 ISSN 2047-8852 R&D Projects: GA ČR(CZ) GAP408/12/1474 Institutional support: RVO:68378025 Keywords : Czech politics * political parties * Czech Republic Subject RIV: AD - Politology ; Political Sciences http://onlinelibrary.wiley.com/doi/10.1111/2047-8852.12082/abstract

  17. The Czech Locative Chameleon

    Directory of Open Access Journals (Sweden)

    Tarald Taraldsen

    2007-12-01

    Full Text Available We show that under certain circumstances, the Czech locative prepositions (LOC show up as directional prepositions (DIR and vice versa, (under different circumstances the Czech DIR PPs show up as LOC. We argue that such a chameleon life of the PPs is structurally dependent.

  18. Czech Republic [2016

    Czech Academy of Sciences Publication Activity Database

    Kudrnáč, Aleš; Petrúšek, Ivan; Linek, Lukáš

    2016-01-01

    Roč. 55, č. 1 (2016), s. 69-75 ISSN 2047-8852 R&D Projects: GA ČR GA13-29032S Institutional support: RVO:68378025 Keywords : Czech politic s * politic al parties * Czech Republic Subject RIV: AD - Politology ; Politic al Sciences http://onlinelibrary.wiley.com/doi/10.1111/2047-8852.12130/full

  19. Czech Republic [2016

    Czech Academy of Sciences Publication Activity Database

    Kudrnáč, Aleš; Petrúšek, Ivan; Linek, Lukáš

    2016-01-01

    Roč. 55, č. 1 (2016), s. 69-75 ISSN 2047-8852 R&D Projects: GA ČR GA13-29032S Institutional support: RVO:68378025 Keywords : Czech politics * political parties * Czech Republic Subject RIV: AD - Politology ; Political Sciences http://onlinelibrary.wiley.com/doi/10.1111/2047-8852.12130/full

  20. Historiography of Czech psychology.

    Science.gov (United States)

    Hoskovcová, Simona; Hoskovec, Jirí; Plháková, Alena; Sebek, Michael; Svancara, Josef; Voboril, Dalibor

    2010-08-01

    The paper is aimed at presenting the development of the Czech historiography of psychology, which was strongly influenced by the political changes in Central and Eastern Europe. The authors deal with the historiography of psychology at the three universities offering an undergraduate program in psychology, located in Prague, Brno, and Olomouc, and at the Institute of Psychology of the Czech Academy of Sciences. Recent research, teaching, textbooks, and journal articles published in Czech and in foreign languages are showcased. The historiography of Czech psychotherapy is mentioned as a special thematic development. Contemporary problems and perspectives in the field of the history of psychology in the Czech Republic are discussed, sources of information are given.

  1. Clinical Stages in Patients with Primary and Subsequent Cancers Based on the Czech Cancer Registry 1976–2005

    Science.gov (United States)

    Štampach, Radim; Dítě, Petr; Kozel, Jiří; Horváth, Teodor; Kubíček, Petr

    2013-01-01

    Of 1,486,984 new cancers registered in the Czech Cancer Registry in 1976-2005, 290,312 (19.5%) were multiple malignant neoplasms (MMNs), of which there were 65,292 primary and 89,796 subsequent cases in men and 59,970 primary and 75,254 subsequent cases in women. The duplicities were higher in women, and the triplicities and others (3–6 MMNs) were higher in men. The most frequent diagnoses were the primary cancers of skin, gastrointestinal and urinary tract, male genital organs, respiratory tract in men, and cancers of skin, breast, female genital organs, and gastrointestinal tract in women. The analysis of the early and advanced clinical stages shows that the number of subsequent advanced stages increased after primary advanced stages. Their time-age-space distributions visualized maps of MMNs in 14 Czech regions. These results support the improvement of algorithms of dispensary care for the early detection of the subsequent neoplasms. PMID:23936674

  2. Clinical stages in patients with primary and subsequent cancers based on the czech cancer registry 1976-2005.

    Science.gov (United States)

    Geryk, Edvard; Stampach, Radim; Dítě, Petr; Kozel, Jiří; Horváth, Teodor; Kubíček, Petr

    2013-01-01

    Of 1,486,984 new cancers registered in the Czech Cancer Registry in 1976-2005, 290,312 (19.5%) were multiple malignant neoplasms (MMNs), of which there were 65,292 primary and 89,796 subsequent cases in men and 59,970 primary and 75,254 subsequent cases in women. The duplicities were higher in women, and the triplicities and others (3-6 MMNs) were higher in men. The most frequent diagnoses were the primary cancers of skin, gastrointestinal and urinary tract, male genital organs, respiratory tract in men, and cancers of skin, breast, female genital organs, and gastrointestinal tract in women. The analysis of the early and advanced clinical stages shows that the number of subsequent advanced stages increased after primary advanced stages. Their time-age-space distributions visualized maps of MMNs in 14 Czech regions. These results support the improvement of algorithms of dispensary care for the early detection of the subsequent neoplasms.

  3. Czech Republic [2011

    Czech Academy of Sciences Publication Activity Database

    Linek, Lukáš

    2011-01-01

    Roč. 50, 7-8 (2011), s. 948-954 ISSN 0304-4130 R&D Projects: GA ČR GAP408/10/0584 Institutional research plan: CEZ:AV0Z70280505 Keywords : Czech politics * political parties * Czech republic Subject RIV: AD - Politology ; Political Science s Impact factor: 1.478, year: 2011 http://onlinelibrary.wiley.com/doi/10.1111/j.1475-6765.2011.02017.x/full

  4. Czech Atomic Law

    OpenAIRE

    Valuš, Josef

    2006-01-01

    The Czech Nuclear law The Nuclear law is an importnat part of the Environmental law. The Nuclear law regulates the peaceful use of nuclear energy and of inonizing radiation, which are the activities potentially dangerous for the environment. This area is a component of a special part of the Environmental law. The ionizing radiation is classified as a particular source of hazard to the environment. This diploma thesis deals with the Czech Nuclear law, and that by means of characterization of a...

  5. The efficacy of ranibizumab treatment in clinical practice in patients with the wet form of age-related macular degeneration. The results of the Czech National Registry.

    Science.gov (United States)

    Chrapek, Oldrich; Jarkovsky, Jiri; Studnicka, Jan; Sin, Martin; Kolar, Petr; Jirkova, Barbora; Dusek, Ladislav; Pitrova, Sarka; Rehak, Jiri

    2015-09-01

    The aim of this communication was to evaluate ranibizumab in the treatment of wet age-related macular degeneration. Anonymised data on treatment efficacy and safety were consecutively entered into the Czech national database. From 01/09/2008 to 25/10/2011, 671 patients/685 eyes treated with ranibizumab monotherapy were entered in the registry. 454 ranibizumab treated eyes and 444 patients were monitored for 12-months. The dependent variable used to monitor disease progression and treatment results was change in visual acuity in the ETDRS (Early Treatment Diabetic Retinopathy Study) chart over time. After 12 months of treatment, a loss of < 15 letters in the ETDRS chart was found in 81.5% of eyes treated with ranibizumab. A gain of ≥ 15 letters was found in 9.7% of eyes on ranibizumab. The results for our patients treated in clinical practice with ranibizumab were poorer than those in the SUSTAIN (Ranibizumab in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration) study. A rationale for this was sought in a sub-analysis. Sub-analysis demonstrated that treatment naive CNV (choroidal neovascularization), occult CNV and lower height of the macular oedema at the outset of the disease may be positive prognostic factors for final visual acuity in anti-VEGF (vascular endothelial growth factor) treated patients.

  6. Sorbitol-Fermenting Enterohemorrhagic Escherichia coli O157:H- Isolates from Czech Patients with Novel Plasmid Composition Not Previously Seen in German Isolates.

    Science.gov (United States)

    Bauwens, Andreas; Marejková, Monika; Middendorf-Bauchart, Barbara; Prager, Rita; Kossow, Annelene; Zhang, Wenlan; Karch, Helge; Mellmann, Alexander; Bielaszewska, Martina

    2017-12-01

    Sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:H - strains, first identified in Germany, have emerged as important pathogens throughout Europe. Besides chromosomally encoded Shiga toxin 2a (the major virulence factor), several putative virulence loci, including the hly , etp , and sfp operons, encoding EHEC hemolysin, type II secretion system proteins, and Sfp fimbriae, respectively, are located on the 121-kb plasmid pSFO157 in German strains. Here we report novel SF EHEC O157:H - strains isolated from patients in the Czech Republic. These strains share the core genomes and chromosomal virulence loci encoding toxins ( stx 2a and the cdtV -ABC operon) and adhesins ( eae -γ, efa1 , lpfA O157OI-141 , and lpfA O157OI-154 ) with German strains but differ essentially in their plasmids. In contrast to all previously detected SF EHEC O157:H - strains, the Czech strains carry two plasmids, of 79 kb and 86 kb. The 79-kb plasmid harbors the sfp operon, but neither of the plasmids contains the hly and etp operons. Sequence analyses demonstrated that the 79-kb plasmid (pSFO157 258/98-1) evolved from pSFO157 of German strains by deletion of a 41,534-bp region via homologous recombination, resulting in loss of the hly and etp operons. The 86-kb plasmid (pSFO157 258/98-2) displays 98% sequence similarity to a 92.7-kb plasmid of an extraintestinal pathogenic E. coli bloodstream isolate. Our finding of this novel plasmid composition in SF EHEC O157:H - strains extends the evolutionary history of EHEC O157 plasmids. Moreover, the unique molecular plasmid characteristics permit the identification of such strains, thereby facilitating further investigations of their geographic distribution, clinical significance, and epidemiology. IMPORTANCE Since their first identification in Germany in 1989, sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H - (nonmotile) strains have emerged as important causes of the life-threatening disease hemolytic

  7. Peutz-Jeguers syndrome: case report and literature review

    Directory of Open Access Journals (Sweden)

    Juvenal da Rocha Torres Neto

    2012-03-01

    Full Text Available The Peutz-Jeghers syndrome is a rare disease characterized by the presence of mucocutaneous melanic pigmentation of the lips, oral mucosa and perioral region, associated with hamartomatous intestinal polyposis. Malignization of the polyps and association with other types of cancer are also usual. Case report: 32-year-old patient, female, white, who had an intestinal occlusion by invagination, discovered during laparotomy, when an intestinal tumor was found as well. The material was sent to anotomopathological analysis. However, the results did not allow to identify the tumor nature due to tumor necrosis. Then, the patient was sent to our service because of the intestinal polyps, and during the interview, the characteristic melanic pigmentation was observed. Videocolonoscopy was performed, with excision of two rectal polyps, identified in the anatomopathological exam as hamartomatous polyps. The patient reported anal imperforation at birth, just like her brother. He had unexplained death. The authors found no correlation of the Peutz-Jeghers syndrome with anal imperforation in the literature and asked the patient if her brother also had the syndrome.A síndrome de Peutz-Jeghers é uma doença rara que tem como características a pigmentação melânica mucocutânea de lábios, regiões perioral e de mucosa bucal associada à polipose hamartomatosa do trato intestinal, com possibilidade de malignização dos pólipos digestivos e associação com outros tipos de câncer. Relato de Caso: Paciente de 32 anos, de gênero feminino, branca, apresentou um quadro de oclusão intestinal por uma invaginação, evidenciada durante laparotomia exploradora, constatando-se, ainda, a presença de uma tumoração intestinal. O material foi encaminhado para exame anatomopatológico; porém, foi inconclusivo para a natureza da tumoração em decorrência da necrose. Em função do pólipo intestinal, a paciente foi encaminhada ao nosso serviço, quando percebemos

  8. THE ROLE OF COLORECTAL POLYPS IN THE ETIOLOGY OF LOWER GASTRO-INTESTINAL BLEEDING IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Claudia OLARU

    2015-12-01

    Full Text Available In children, colorectal polyps most commonly present with rectal bleeding. The aim of this study was to establish some correlations between clinical, endoscopic/histopathological aspects and therapeutic options in pediatric colorectal polyps. The experimental group included 253 children aged between 1 and 18 years, patients being included based on the presence of rectal bleeding associated with abdominal pain and/or constipation, established through colonoscopic examination. 39 polyps were identified: 37 with single lesions and 2 with multiple lesions. The solitary polyps, located mostly in the rectum and sigmoid, having sizes between 1 and 2.5 cm, were removed during the same colonoscopy. Pathology showed inflammatory aspects and two cases of hamartomatous polyps in a Peutz-Jeghers and a Bannayan-Ryley syndrome. Colonoscopy should routinely be recommended in children with suspected polyps; in multiple lesions, periodic surveillance by colonoscopy and histology is mandatory.

  9. Thyroid, Renal, and Breast Carcinomas, Chondrosarcoma, Colon Adenomas, and Ganglioneuroma: A New Cancer Syndrome, FAP, or Just Coincidence

    Directory of Open Access Journals (Sweden)

    Ihab Shafek Atta

    2016-01-01

    Full Text Available We are presenting a case associated with papillary thyroid carcinoma, renal cell carcinoma, invasive mammary carcinoma, chondrosarcoma, benign ganglioneuroma, and numerous colon adenomas. The patient had a family history of colon cancer, kidney and bladder cancers, lung cancer, thyroid cancer, leukemia, and throat and mouth cancers. She was diagnosed with colonic villous adenoma at the age of 41 followed by thyroid, renal, and breast cancers and chondrosarcoma at the ages of 48, 64, 71, and 74, respectively. Additionally, we included a table with the most common familial cancer syndromes with one or more benign or malignant tumors diagnosed in our case, namely, FAP, HNPCC, Cowden, Peutz-Jeghers, renal cancer, tuberous sclerosis, VHL, breast/other, breast/ovarian, Carney, Werner’s, Bloom, Li-Fraumeni, xeroderma pigmentosum, ataxia-telangiectasia, osteochondromatosis, retinoblastoma, and MEN2A.

  10. Thyroid, Renal, and Breast Carcinomas, Chondrosarcoma, Colon Adenomas, and Ganglioneuroma: A New Cancer Syndrome, FAP, or Just Coincidence

    Science.gov (United States)

    Atta, Ihab Shafek; AlQahtani, Fahd Nasser

    2016-01-01

    We are presenting a case associated with papillary thyroid carcinoma, renal cell carcinoma, invasive mammary carcinoma, chondrosarcoma, benign ganglioneuroma, and numerous colon adenomas. The patient had a family history of colon cancer, kidney and bladder cancers, lung cancer, thyroid cancer, leukemia, and throat and mouth cancers. She was diagnosed with colonic villous adenoma at the age of 41 followed by thyroid, renal, and breast cancers and chondrosarcoma at the ages of 48, 64, 71, and 74, respectively. Additionally, we included a table with the most common familial cancer syndromes with one or more benign or malignant tumors diagnosed in our case, namely, FAP, HNPCC, Cowden, Peutz-Jeghers, renal cancer, tuberous sclerosis, VHL, breast/other, breast/ovarian, Carney, Werner's, Bloom, Li-Fraumeni, xeroderma pigmentosum, ataxia-telangiectasia, osteochondromatosis, retinoblastoma, and MEN2A. PMID:27087812

  11. [Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis].

    Science.gov (United States)

    Rau, T T; Dawson, H; Hartmann, A; Rüschoff, J

    2017-05-01

    The pathologist can contribute to recognizing hereditary causes of colorectal cancer via morphology. By identifying so-called index patients, it is possible to take preventive measures in affected families. The precise definition of the clinical presentation and the histopathological phenotype help to narrow the spectrum of expected genetic alterations. Novelties within Lynch syndrome include the recognition of EPCAM as a fifth gene locus, as well as the newly defined Lynch-like syndrome with evidence of somatic mismatch repair (MMR) mutations. With regard to polyposis-associated syndromes, the spectrum of polyps, whether serrated, hamartomatous or classic adenoma, is of crucial importance. The resulting differential diagnosis includes (attenuated) familial adenomatous polyposis ([a]FAP), MUTYH-associated polyposis (MAP), polymerase proofreading-associated polyposis (PPAP), phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS), Peutz-Jeghers syndrome and juvenile polyposis, each with a specific genetic background.

  12. Ovarian Sex Cord-Stromal Tumors.

    Science.gov (United States)

    Schultz, Kris Ann P; Harris, Anne K; Schneider, Dominik T; Young, Robert H; Brown, Jubilee; Gershenson, David M; Dehner, Louis P; Hill, D Ashley; Messinger, Yoav H; Frazier, A Lindsay

    2016-10-01

    Ovarian sex cord-stromal tumors are clinically significant heterogeneous tumors that include several pathologic types. These tumors are often found in adolescents and young adults and can present with hormonal manifestations as well as signs and symptoms of a pelvic mass. Serum tumor markers may assist in preoperative diagnosis and surveillance. Several subtypes are associated with genetic predisposition, including those observed in patients with Peutz-Jegher syndrome. Recent studies have elucidated the relationship between Sertoli-Leydig cell tumors and DICER1 mutations. When classified as International Federation of Gynecology and Obstetrics stage Ia, most subtypes may be treated with surgery alone. Higher stage or recurrent tumors have variable prognoses that range from a usually rapid course in poorly differentiated Sertoli-Leydig cell tumor to an often prolonged course in adult granulosa cell tumors. New understanding of the molecular pathogenesis of these tumors may pave the way for novel therapeutics.

  13. [Hypertension and hypercholesterolemia in the Czech population].

    Science.gov (United States)

    Wohlfahrt, Peter; Krajčoviechová, Alena; Bruthans, Jan; Cífková, Renata

    Hypertension and hypercholesterolemia are inter-related ad mutually potentiating cardiovascular risk factors, which, when occurring together, strongly accelerate atherosclerosis and significantly increase cardiovascular risk.The aim of our study was to assess the prevalence and control of both risk factors in the Czech population. A 1 % population random sample aged 40-64 years was examined within the Czech post-MONICA in 2006-2009. Hypertension was defined as systolic blood pressure 140 mm Hg and/or diastolic BP 90 mm Hg or use of antihypertensive medication. Hypercholesterolemia was defined according to cardiovascular risk and LDL-cholesterol levels or use of lipid-lowering drugs. In a group of 2 508 persons (51 % of females), hypertension was found in 52 % and hypercholesterolemia in 40 % of examined individuals. Both risk factors occurred together in 30 % of subjects. While lipid-lowering drugs were used by 39 % of individuals with hypertension and hypercholesterolemia, target LDL-cholesterol were achieved by only 42 % of treated individuals. Only a total of 10 % individuals with both hypertension and hypercholesterolemia achieved target levels for both risk factors. Treatment and control of hypercholesterolemia in patients with hypertension remains unsatisfactory in the Czech Republic. Taking into account the high prevalence of hypercholesterolemia and the substantial increase in cardiovascular risk, lipid-lowering drugs should be considered in each patient with hypertension.Key words: antihypertensive drugs - Czech post-MONICA - lipid-lowering drugs - SCORE - target values - total cardiovascular risk.

  14. Czech Republic [2017

    Czech Academy of Sciences Publication Activity Database

    Petrúšek, Ivan; Kudrnáč, Aleš

    2017-01-01

    Roč. 56, č. 1 (2017), s. 70-78 ISSN 2047-8852 R&D Projects: GA ČR GA16-04885S Institutional support: RVO:68378025 Keywords : Czech politics * political parties * elections Subject RIV: AD - Politology ; Political Sciences OBOR OECD: Political science http://onlinelibrary.wiley.com/doi/10.1111/2047-8852.12161/full

  15. Historiography of Czech psychology

    Czech Academy of Sciences Publication Activity Database

    Hoskovcová, S.; Hoskovec, J.; Plháková, A.; Šebek, M.; Švancara, J.; Vobořil, Dalibor

    2010-01-01

    Roč. 13, č. 3 (2010), s. 309-334 ISSN 1093-4510 Institutional research plan: CEZ:AV0Z70250504 Keywords : Czech psychologists * Czechoslovak psychology * ideologic influences on psychology Subject RIV: AN - Psychology Impact factor: 0.500, year: 2010

  16. The contemporary czech art groups

    OpenAIRE

    Nývlt, Matěj

    2011-01-01

    Bachelor's thesis describes the current Czech art droups and their directly related topics. The introduction describes the general problems of creation iside the art group and puts in to historical context of development of Czech art for the last two hundred years. Next is the theme of artistic groups widened by the choice of some of the world's art groups. The current czech art groups are described in several medallions representing the youngest generation groups that are actively involved i...

  17. Uukuniemi virus, Czech Republic.

    Science.gov (United States)

    Papa, Anna; Zelená, Hana; Papadopoulou, Elpida; Mrázek, Jakub

    2018-04-20

    Following the identification of severe fever with thrombocytopenia syndrome and Heartland viruses, the interest on tick-borne phleboviruses has increased rapidly. Uukuniemi virus has been proposed as a model for tick-borne phleboviruses. However, the number of available sequences is limited. In the current study we performed whole-genome sequencing on two Uukuniemi viral strains isolated in 2000 and 2004 from Ixodes ricinus ticks in the Czech Republic. Both strains cluster together with Potepli63 strain isolated in the country in 1963. Although the Czech strains were isolated many years apart, a high identity was seen at the nucleotide and amino acid levels, suggesting that UUKV has a relatively stable genome. Copyright © 2018 Elsevier GmbH. All rights reserved.

  18. Hamartomatous polyposis syndromes

    DEFF Research Database (Denmark)

    Jelsig, Anne Marie; Qvist, Niels; Brusgaard, Klaus

    2014-01-01

    Hamartomatous Polyposis Syndromes (HPS) are genetic syndromes, which include Peutz-Jeghers syndrome, Juvenile polyposis syndrome, PTEN hamartoma tumour syndrome (Cowden Syndrom, Bannayan-Riley-Ruvalcaba and Proteus Syndrome) as well as hereditary mixed polyposis syndrome. Other syndromes such as ......Hamartomatous Polyposis Syndromes (HPS) are genetic syndromes, which include Peutz-Jeghers syndrome, Juvenile polyposis syndrome, PTEN hamartoma tumour syndrome (Cowden Syndrom, Bannayan-Riley-Ruvalcaba and Proteus Syndrome) as well as hereditary mixed polyposis syndrome. Other syndromes...

  19. Healthy lifestyle and Czech consumers

    OpenAIRE

    Kubešová, Jana

    2011-01-01

    This thesis is focused on healthy lifestyle. It concentrates specifically on impact on human health and which lifestyle lives Czech population. This work summarizes the principles of helathy lifestyle and reveals lifestyles of Czech people with market segmentation and MML-TGI data in the practical part. This can help firms in targeting and addressing people within healthy lifestyle.

  20. SEs in the Czech Republic

    NARCIS (Netherlands)

    Cremers, Jan; Carlson, Anders; Cremers, Jan; Stollt, Michael; Vitols, Sigurt

    2013-01-01

    In Chapter 5, by Jan Cremers and Anders Carlson, the SE is sutuated in the corporate company landscape. The extraordinary share that the Czech Republic accounts for in the total number of SEs created is analysed. The SE is mainly an alternative to Czech national corporate forms, without a

  1. Genome-Wide Screening of Cytogenetic Abnormalities in Multiple Myeloma Patients Using Array-CGH Technique: A Czech Multicenter Experience

    Directory of Open Access Journals (Sweden)

    Jan Smetana

    2014-01-01

    Full Text Available Characteristic recurrent copy number aberrations (CNAs play a key role in multiple myeloma (MM pathogenesis and have important prognostic significance for MM patients. Array-based comparative genomic hybridization (aCGH provides a powerful tool for genome-wide classification of CNAs and thus should be implemented into MM routine diagnostics. We demonstrate the possibility of effective utilization of oligonucleotide-based aCGH in 91 MM patients. Chromosomal aberrations associated with effect on the prognosis of MM were initially evaluated by I-FISH and were found in 93.4% (85/91. Incidence of hyperdiploidy was 49.5% (45/91; del(13(q14 was detected in 57.1% (52/91; gain(1(q21 occurred in 58.2% (53/91; del(17(p13 was observed in 15.4% (14/91; and t(4;14(p16;q32 was found in 18.6% (16/86. Genome-wide screening using Agilent 44K aCGH microarrays revealed copy number alterations in 100% (91/91. Most common deletions were found at 13q (58.9%, 1p (39.6%, and 8p (31.1%, whereas gain of whole 1q was the most often duplicated region (50.6%. Furthermore, frequent homozygous deletions of genes playing important role in myeloma biology such as TRAF3, BIRC1/BIRC2, RB1, or CDKN2C were observed. Taken together, we demonstrated the utilization of aCGH technique in clinical diagnostics as powerful tool for identification of unbalanced genomic abnormalities with prognostic significance for MM patients.

  2. Czech Delegation visiting the LHC magnet string test

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    List of participants: Czech Technical University, Prague; Charles University, Prague; Academy of Sciences of the Czech Republic; Ministry of Education, Youth and Sports of the Czech Republic and Association of Innovation Enterprising, Czech Republic

  3. Astronomy in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Palouš, Jan; Hadrava, Petr

    -, č. 128 (2007), s. 3-3 ISSN 0722-6691 Institutional research plan: CEZ:AV0Z10030501 Keywords : astronomy * astropohysics * Czech republic Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

  4. [The mortality of patients with diabetes mellitus using oral antidiabetic drugs in the Czech Republic decreased over the decade of 2003-2013 and came closer to the population average].

    Science.gov (United States)

    Brož, Jan; Honěk, Petr; Dušek, Ladislav; Pavlík, Tomáš; Kvapil, Milan

    2015-11-01

    Every year official data is published which describes the care of patients with diabetes mellitus in the Czech Republic. An overall number of individuals with diabetes, the number of newly reported cases and the number of patient deaths is always specified. However this data does not allow us to identify the differences in mortality between the individual cohorts of diabetic patients in relation to therapy. Comparison of the mortality development in the periods of 2002-2006 and 2010-2013 in a representative sample of the patient population with type 2 diabetes mellitus using oral antidiabetic drugs, kept in the database of the General Health Insurance Company of the Czech Republic (VZP) which provided health care coverage for 63% of Czech population in 2013. A retrospective epidemiologic analysis. We identified all individuals in the VZP database who had a record of DM diagnosis (E10-E16 based on ICD 10) or who had any antidiabetic therapy prescribed (ATC group A10) in the periods of 2002-2008 and 2009-2013. We only selected those patients for the analysis who were treated with oral antidiabetic medicines (in the given year or the preceding years they had a record of treatment with at least one medicine from A10B group, while having no record of treatment with medicines from A10A group within both years). 237,665 individuals met the selected criteria in 2003 and 315,418 individuals in 2013. Mortality rates dropped for all age groups (from 2003-2013): for 50-59 year olds by 1.2%-0.7%; in 60-69 year olds by 2.6%-1.6%; for 70-79 year olds by 5.8%-3.5%. In 2013 mortality rates came close to the general population where for the same age groups they reached 0.6%, 1.5% and 3.4% respectively. When expressed in relative terms, the mortality among 50-59 year olds declined by 42% (Czechia by 25%), among 60-69 year olds by 39% (Czechia by 17%) and among 70-79 year olds by 40% (Czechia by 28%) from the year 2003. The decline in mortality among the patients with DM treated with

  5. Mammographic dose survey in the Czech Republic

    International Nuclear Information System (INIS)

    Novak, Leos; Rada, Jiri

    2006-01-01

    At present, it is generally accepted that the average dose to the glandular tissue is the most reasonable dose descriptor in mammography with regard to the risk of breast cancer induced by ionizing radiation. It is advantageous to use the quantity mean glandular dose M.G.D. for setting of diagnostic reference levels (D.R.L.) as well, although the quantity is not directly measurable as it is the case of D.R.L. quantities for other imaging modalities. The reason is that a directly measurable quantity suitable for mammography, incident air kerma Ki, depends a lot on a beam quality. The influence of the beam quality (expressed by tube voltage, half value layer and combination of anode/filter material) is already included in calculation of mean glandular dose. To assess a radiation burden of patients due to mammography at a national level a representative dose survey is needed to carry out. Such a study provides statistically significant dose data for setting of the national diagnostic reference levels. National Radiation Protection Institute is performing the study in the Czech Republic since the year 2005.On a basis of presented data, it could be concluded, that the situation in the Czech Republic with respect to patient doses in mammography is encouraging and that the requirements of European Commission are well fulfilled. However, it is obvious, that the obtained results can not be considered as statistically significant at the moment, because the data were not collected from a representative sample of centers, which should observe a distribution of X-ray unit types, type of a mammographic center (screening/non screening ones) and also a locality of a center. The dose survey still continues to cover the whole Czech Republic with the main task to determine new national diagnostic reference levels and to find out optimized standards for carrying out the examinations with respect to patient doses and image quality. (authors)

  6. Fashion designers on the Czech market

    OpenAIRE

    Hinková, Barbora

    2014-01-01

    This Master's Thesis deals with the Czech fashion scene. Development of fashion is outlined in the introduction. It should help to understand the whole market. The work deals with marketing of fashion brands and focuses primarily on marketing Czech fashion brands offering fashions for women. Czech fashion scene is analyzed in detail and pointed out the weaknesses that need to be improved. In connection with the findings outlined here is a solution that should help Czech fashion scene.

  7. Slavia takes the Czech path

    International Nuclear Information System (INIS)

    Haluza, I.

    2007-01-01

    Biodiesel was the main reason Slavia Capital bought the oil processing company, Palma Tumys, Bratislava last year. The biofuels added to fuel produced from oil are one of the core products of this investment group. But today Slavia is profiting more from the production of edible oils and margarine produced by the Palma Group. It has benefited from the global increase in food prices. But Palma is also profiting from the experience and contacts of its new Czech managers appointed by the new owner. They have found a place in Czech stores for Slovak oils and margarines. In the past the company only used to supply its products to Czech bakers. And they even found a place for biodiesel. Petr Zejdlik is Czech and is the chairman of the board of Palma Group. Matej Valtr, is also Czech and is responsible for managing company strategies. They replaced the former owners, original Slovak privatizers who used to manage the company and did not do badly. They managed to keep one of the biggest Slovak food processing companies in good shape and in profit and j with stable revenues of around 90 mil. EUR. But finally they gave in to international competition from Bunge, Cargill and Archer Daniels Midland and sold the company to a financially strong investor. (author)

  8. Czech spoken in Bohemia and Moravia

    NARCIS (Netherlands)

    Šimáčková, Š.; Podlipský, V.J.; Chládková, K.

    2012-01-01

    As a western Slavic language of the Indo-European family, Czech is closest to Slovak and Polish. It is spoken as a native language by nearly 10 million people in the Czech Republic (Czech Statistical Office n.d.). About two million people living abroad, mostly in the USA, Canada, Austria, Germany,

  9. American Elements in Czech Parody

    Czech Academy of Sciences Publication Activity Database

    Hemelíková, Blanka

    2015-01-01

    Roč. 48, č. 1 (2015), s. 102-113 ISSN 0022-3840 Institutional support: RVO:68378068 Keywords : Czech interwar literature * parody * Brdečka, Jiří * Kuděj, Zdeněk Matěj * americanism Subject RIV: AJ - Letters, Mass-media, Audiovision Impact factor: 0.070, year: 2015

  10. Protect Czech park from development

    Czech Academy of Sciences Publication Activity Database

    Kindlmann, Pavel; Křenová, Zdeňka

    2016-01-01

    Roč. 531, č. 7595 (2016), s. 448-448 ISSN 0028-0836 Institutional support: RVO:86652079 Keywords : Protect Czech park Subject RIV: EH - Ecology, Behaviour OBOR OECD: Environmental sciences (social aspects to be 5.7) Impact factor: 40.137, year: 2016

  11. The Corpus of Czech Verse

    Czech Academy of Sciences Publication Activity Database

    Plecháč, Petr; Kolár, Robert

    2015-01-01

    Roč. 2, č. 1 (2015), s. 107-118 ISSN 2346-6901 R&D Projects: GA ČR GAP406/11/1825 Institutional support: RVO:68378068 Keywords : Czech poetry * versification * corpus linguistics * theory of verse Subject RIV: AJ - Letters, Mass-media, Audiovision

  12. Czech Student Attitudes towards Geography

    Science.gov (United States)

    Kubiatko, Milan; Janko, Tomas; Mrazkova, Katerina

    2012-01-01

    This study investigates 540 Czech lower secondary students' attitudes towards geography. It examined the general influence of gender and grade level on attitudes towards geography with an emphasis on four specific areas in particular: geography as a school subject; geography and the environment; the importance of geography; and the relevance of…

  13. Formal tautologies in Czech language

    OpenAIRE

    Bílková, Jana

    2006-01-01

    The main purpose ofthis work was to describe and classify FT used in the contemporary Czech language and to demonstrate formal and semantic variety and high functional potential of this specific class of sentences. Powered by TCPDF (www.tcpdf.org)

  14. Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLS(B) Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment.

    Science.gov (United States)

    Tkadlec, Jan; Vařeková, Eva; Pantůček, Roman; Doškař, Jiří; Růžičková, Vladislava; Botka, Tibor; Fila, Libor; Melter, Oto

    2015-08-01

    Staphylococcus aureus is one of the most frequent pathogens infecting the respiratory tract of patients with cystic fibrosis (CF). This study was the first to examine S. aureus isolates from CF patients in the Czech Republic. Among 100 S. aureus isolates from 92 of 107 observed patients, we found a high prevalence of resistance to macrolide-lincosamide-streptogramin B (MLS(B)) antibiotics (56%). More than half of the resistant strains (29 of 56) carried a mutation in the MLS(B) target site. The emergence of MLS(B) resistance and mutations conferring resistance to MLS(B) antibiotics was associated with azithromycin treatment (p=0.000000184 and p=0.000681, respectively). Methicillin resistance was only detected in 3% of isolates and the rate of resistance to other antibiotics did not exceed 12%. The prevalence of small-colony variant (SCV) strains was relatively low (9%) and eight of nine isolates with the SCV phenotype were thymidine dependent. The study population of S. aureus was heterogeneous in structure and both the most prevalent community-associated and hospital-acquired clonal lineages were represented. Of the virulence genes, enterotoxin genes seg (n=52), sei (n=49), and sec (n=16) were the most frequently detected among the isolates. The PVL genes (lukS-PV and lukF-PV) have not been revealed in any of the isolates.

  15. Corruption Perception in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Naxera Vladimír

    2015-04-01

    Full Text Available This paper is focused on the issue of corruption perception in the Czech Republic. After introducing the general framework for corruption perception in post-communist countries, this paper uses the Czech Republic as an example of the ways in which corruption is perceived, the areas Czech citizens feel are most plagued by corruption, and the ways in which corruption perception has transformed in terms of post-communist developments. This paper points out the differences in corruption perception among Czech citizens, the media and political parties and their representatives. The conclusion of the paper attempts to answer the question of how corruption perception has affected the overall perception of the democratic regime in the Czech Republic. It also asks questions regarding how this has influenced the evaluation of democracy and the relationship between Czech citizens and political institutions, including individual political parties.

  16. Double-balloon enteroscopy: a descriptive study of 50 explorations Enteroscopia de doble balón: estudio descriptivo de 50 exploraciones

    Directory of Open Access Journals (Sweden)

    E. Pérez-Cuadrado

    2006-02-01

    Full Text Available Aim: to evaluate the utility of double-balloon enteroscopy for small-bowel disease. Design: a prospective study of 50 consecutive enteroscopies performed from December 2004 to July 2005 to analyze diagnoses and treatments. Patients: 44 patients (33 had undergone a previous capsule endoscopy with indications for obscure digestive hemorrhage, angiodysplasia, Peutz-Jeghers syndrome, ulcer, suspected Crohn's disease, tumors, and refractory celiac disease. Results: we carried out enteroscopy studies in 44 patients by the oral route and, in 6 additional patients, by both the oral and anal routes. We reached the ileon with the oral route in all cases but one (jejunal stenosis, and in 4 cases out of 7 with the anal route, with an average duration of 73 minutes. We found angiodysplasia in 19 cases, as well as NSAID-related enteropathy, Crohn's disease, diverticulosis, and Waldenström's disease. We performed biopsies in 31% of cases with diagnoses of adenocarcinoma, lymphangiectasia secondary to tumor in celiac disease, and Whipple's disease. We treated 19 patients with angiodysplasia (1 to 20 synchronous lesions with argon, and 4 patients with polyps using polipectomy (sporadic polyps or Peutz-Jeghers syndrome. A retained capsule in one patient with stenosis was removed. Conclusions: double-balloon enteroscopy is a useful and effective technique in the diagnosis and treatment of small intestine diseases, thus complementing capsule endoscopy. More studies are needed to analyze its impact on the management of this condition.Objetivo: valorar la utilidad de la enteroscopia de doble balón en enfermedades de intestino delgado. Diseño: estudio prospectivo descriptivo de 50 enteroscopias consecutivas (diciembre 2004 a julio 2005, analizando diagnóstico y terapéutica. Pacientes: cuarenta y cuatro pacientes (33 con cápsula endoscópica previa con hemorragia digestiva oculta o lesiones detectadas mediante cápsula (angiodisplasias, pólipos, úlceras

  17. Czech Republic joins IPPOG as member

    CERN Multimedia

    'marcelloni, claudia

    2018-01-01

    Czech Republic became an official IPPOG member on April 21 2018. The MOU between Czech Republic and IPPOG was previously signed by the director of the Institute of Physics of the Academy of Sciences of the Czech Republic. IPPOG chairs confirmed the agreement by signing the MOU during the meeting in Pisa in presence of IPPOG representative for Czech Republic dr. Vojtech Pleskot from the Faculty of Mathematics and Physics, Charles University in Prague. Dr. Vojtech Pleskot replaces Dr. Jiri Rames who did an excellent job during his long term work in the EPPOG and IPPOG.

  18. Anorexia nervosa in Czech republic

    OpenAIRE

    HEJNOVÁ, Jana

    2017-01-01

    The thesis focuses on anorexia from the onset of the disease to the possible treatment in the Czech Republic. The theoretical part defines anorexia nervosa, offers insight into potential risk factors and also concentrates on situations that can cause anorexia. Next, this part provides a basic overview of a balanced diet and informs about the use of social work in prevention and follow-up care. Furthermore, it summarizes medical care and therapies used in the treatment of this disease. The pra...

  19. Czech art history and Marxism

    Directory of Open Access Journals (Sweden)

    Milena Bartlová

    2012-12-01

    Full Text Available Czech art history in the 20th century has been strongly informed by the tradition of the Vienna School. After the Communist takeover of power in 1948, Marxism – or more precisely Marxism-Leninism – became a compulsory philosophical approach. After a brief Stalinist phase, an ‘iconologic turn’ was construed by Jaromír Neumann before 1960: iconology was reframed in terms of Dvořák´s ‘spiritual history’ and the result was labelled Marxist, as it enabled to provide a direct access to the ideology of the past without having to pay attention to class and social relations. Frederick Antal´s or Arnold Hauser´s social history of art was rejected, the main focus was on the noetic qualities of artworks and the main topic the debate of realism. As a result, Czech art history was pursued as an elitist discipline in the humanist tradition, but it did not need to participate in the search for ‘humanist Marxism’ or revisionism which was typical for the East-Central Europe in the 1960. Dvořák-type iconology combined with formalist approach and belief in a validity of the laws of develompent remained attractive for Czech art history up to the 1990s.

  20. MECP2 mutations in Czech patients with Rett syndrome and Rett-like phenotypes: novel mutations, genotype-phenotype correlations and validation of high-resolution melting analysis for mutation scanning.

    Science.gov (United States)

    Zahorakova, Daniela; Lelkova, Petra; Gregor, Vladimir; Magner, Martin; Zeman, Jiri; Martasek, Pavel

    2016-07-01

    Rett syndrome (RTT) is an X-linked neurodevelopmental disorder characterized by developmental regression with loss of motor, communication and social skills, onset of stereotypic hand movements and often seizures. RTT is primarily caused by de novo mutations in the methyl-CpG-binding protein 2 gene (MECP2). We established a high-resolution melting (HRM) technique for mutation scanning of the MECP2 gene and performed analyses in Czech patients with RTT, autism spectrum conditions and intellectual disability with Rett-like features. In the cases with confirmed MECP2 mutations, we determined X-chromosome inactivation (XCI), examined the relationships between genotype and clinical severity and evaluated the modifying influence of XCI. Our results demonstrate that HRM analysis is a reliable method for the detection of point mutations, small deletions and duplications in the MECP2 gene. We identified 29 pathogenic mutations in 75 girls, including four novel mutations: c.155_1189del1035;909_932inv;insC, c.573delC, c.857_858dupAA and c.1163_1200del38. Skewed XCI (ratio >75%) was found in 19.3% of the girls, but no gross divergence in clinical severity was observed. Our findings confirm a high mutation frequency in classic RTT (92%) and a correlation between the MECP2 mutation type and clinical severity. We also demonstrate limitations of XCI in explaining all of the phenotypic differences in RTT.

  1. Body parameters of Czech breastfed children compared to the Czech references and WHO growth standards.

    Science.gov (United States)

    Riedlová, Jitka; Vignerová, Jana; Paulová, Markéta; Musil, Vladimír; Brabec, Marek; Schneidrová, Dagmar

    2017-11-01

    The study concerns the comparison of percentile curves of Czech breastfed children with Czech national references from 1991 and 2001 and WHO growth standards. Growth charts of breastfed children demonstrate different curve shapes, especially in the first months of life. Incorrect interpretation of the growth curve could lead to premature introduction of complementary foods or infant formula. The comparison of four body parameters of Czech breastfed children with currently used Czech national references and WHO standards in order to recommend that Czech paediatricians use either Czech references or WHO standards in their practice. Nine hundred and sixty breastfed children were included in the study of length-for-age, head circumference-for-age, weight-for-age and weight-for-length parameters. All percentile curves were compared. Values of the 50th percentile expressed in z-scores based on both Czech references and WHO standards were tested. The study confirmed results of previous surveys documenting that growth of breastfed children is specific. Nevertheless, percentile curves of growth parameters of Czech breastfed children are closer to Czech references than WHO standards. The Czech national references fulfil the needs of Czech paediatricians (with pointing to specifics of breastfed child growth) and WHO standards are suitable, especially for international comparison.

  2. Czech Higher Education Still at the Crossroads

    Czech Academy of Sciences Publication Activity Database

    Matějů, Petr; Simonová, Natalie

    -, - (2005), s. 1-15 R&D Projects: GA AV ČR(CZ) IBS7028302 Institutional research plan: CEZ:AV0Z70280505 Keywords : czech higher education * autonomy of universities Subject RIV: AO - Sociology, Demography http://www.cee-socialscience.net/archive/interdisciplinary/czech/article1.html

  3. Grey Literature in the Czech Republic

    OpenAIRE

    Pejšová, Petra; Pfeiferová, Martina

    2008-01-01

    Contribution summarizes activities concerning grey literature in the Czech Republic. Contribution describes relationships between systems/projects collecting grey literature and position grey literature in the Czech Digital Library. Contribution is especially focused on a project “The Digital Library for Grey Literature –Functional Model and Pilot Implementation”, which solves the State Technical Library.

  4. The Czech National Grid Infrastructure

    Science.gov (United States)

    Chudoba, J.; Křenková, I.; Mulač, M.; Ruda, M.; Sitera, J.

    2017-10-01

    The Czech National Grid Infrastructure is operated by MetaCentrum, a CESNET department responsible for coordinating and managing activities related to distributed computing. CESNET as the Czech National Research and Education Network (NREN) provides many e-infrastructure services, which are used by 94% of the scientific and research community in the Czech Republic. Computing and storage resources owned by different organizations are connected by fast enough network to provide transparent access to all resources. We describe in more detail the computing infrastructure, which is based on several different technologies and covers grid, cloud and map-reduce environment. While the largest part of CPUs is still accessible via distributed torque servers, providing environment for long batch jobs, part of infrastructure is available via standard EGI tools in EGI, subset of NGI resources is provided into EGI FedCloud environment with cloud interface and there is also Hadoop cluster provided by the same e-infrastructure.A broad spectrum of computing servers is offered; users can choose from standard 2 CPU servers to large SMP machines with up to 6 TB of RAM or servers with GPU cards. Different groups have different priorities on various resources, resource owners can even have an exclusive access. The software is distributed via AFS. Storage servers offering up to tens of terabytes of disk space to individual users are connected via NFS4 on top of GPFS and access to long term HSM storage with peta-byte capacity is also provided. Overview of available resources and recent statistics of usage will be given.

  5. Business Model for Czech Agribusiness

    Directory of Open Access Journals (Sweden)

    Poláková Jana

    2015-09-01

    Full Text Available Business modelling facilitates the understanding of value creation logic in organizations in general. Identifying the components of business models based on different criteria helps understanding the fundamentals of business and the position of entrepreneurs and managers in companies. The present research is focused on the definition of a specific business model for the Czech agribusiness sector. Based on the theoretical background and evaluation of selected business models, the aim is to create a new business model, using components which take into account the specifics of this particular industry.

  6. Simulations at Czech poultry market

    Directory of Open Access Journals (Sweden)

    Lenka Rumánková

    2012-01-01

    Full Text Available This paper defines the possible scenarios of the development of the poultry market in the Czech Republic, in view of the trends in production, consumption and foreign trade. The individual scenarios are based upon the forecasts of selected factors that have a substantial impact on the poultry market and whose changes can be expected in the subsequent years with great likelihood. The article sets out and addresses various scenarios for the period of 2012–2014. The scenarios are based upon the partial equilibrium model of the poultry market, which has been derived on the basis of time series and panel data within the years 1995–2009. The conducted analysis clearly shows that changes in the prices of agricultural producers will have an effect on changes in the production of poultry meat, an increase in VAT through consumer prices will impact the rate of domestic consumption, as well as changes in disposable income. Similarly, a change in the exchange rate will have an effect on the amount of poultry imported into the Czech Republic.

  7. Breast cancer in the Czech Republic

    International Nuclear Information System (INIS)

    Hodacova, L.

    2003-01-01

    Background. Malignant neoplasms present one of the most serious chapters of morbidity, mortality, and the overall perspective of the health status of Czech population. Malignant neoplasms have been registered in the Czech Republic since the end of the 1950s. Guarantor of the all-state registry is the Institute of Health Information and Statistics of the Czech Republic (IHIS CR), and conceptual and methodological steering is performed by the Council of the Czech Cancer Registry. The five most frequently diagnoses in Czech males and seven most frequently diagnoses in Czech females were followed during the last 20 years. The most frequent malignant neoplasm in Czech women is breast cancer. Conclusions. The incidence of this cancer has increased by 75% during the studied period. During the year 2001, three pilot studies of preventive mammography screening were done in the country. One case of asymptomatic breast cancer in the study costs 80,000 Kc (in reality it was 120,000 K.). These costs are markedly lower than the combined therapy of advanced stages of breast cancer. (author)

  8. Environmental accounting in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Jaroslava Hyršlová

    2006-01-01

    Full Text Available The aim of the paper is to demonstrate the existing state of environmental accounting as used in business and to discuss the shift of system application, focusing on the enterprises that have already implemented the environmental management systems. The paper summarizes the research outcomes of 2005, carried out by the Czech Environmental Management Centre and the Czech Environmental Information Agency. The research was targeted at the experience of companies with an implementation and operation of the environmental accounting system in the Czech Republic. The subject of the research was tracing and evaluating of environmental costs and benefit of the system of environmental accounting for company management.

  9. European and Czech principles of contract law

    OpenAIRE

    Horáková, Monika

    2008-01-01

    8 Summary European and Czech Principles of Contract Law This thesis is focused on principles of contract law. In the first instance, it explains the theoretical conception of principles of law and adverts to their status in the Czech legal system. The second Chapter of the thesis dissertates about basic principles of the Czech private law starting with the principle of freedom of contract, ends with the principles of good faith and fair dealing. The main part of the thesis deals with the Euro...

  10. Professional Internet Information Source Used as Educational Resource for Patients with Insulin-Treated Diabetes in the Czech Republic: A 5-Year Analysis of Operations

    Czech Academy of Sciences Publication Activity Database

    Brož, J.; Brabec, Marek; Brožová, K.; Cibulková, I.; Janíčková Žďárská, D.; Hartmann, D.

    2016-01-01

    Roč. 128, č. 3 (2016), s. 153-154 ISSN 0043-5325 Institutional support: RVO:67985807 Keywords : diabetes * patient web page * statistical modeling Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 0.974, year: 2016

  11. Spa, Spa Tourism and Wellness Tourism in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Vystoupil Jiří

    2017-06-01

    Full Text Available The aim of this paper is to compare and assess the position of the spa and wellness sector in the structure of tourism in the Czech Republic. In this context, the article deals with the brief history of the Czech spa tourism and the development of spa tourism in the spa resorts, including the focus of specialized literature review. The methodological part consists of an explanation of the existing statistical information about the spa sector. The main part of the paper deals with the geographic analysis of current spa centres (the capacity of spa and total collective accommodation facilities, the number of spa patients and guests, guest attendance and their geographical structure. The assessment also includes the determination of the importance of the spa for overall spa tourism. Furthermore, the paper also deals with the development and localization of the selected forms of wellness tourism. As a pilot example, aquaparks built especially in the last 20 years in the Czech Republic were chosen.

  12. Energy policy of the Czech Republic

    International Nuclear Information System (INIS)

    Pecina, M.

    2004-01-01

    In this presentation author deals with the state and perspectives of energy production in the Czech Republic up to 2030 year. Share of energy consumption as well as perspectives of nuclear energy are discussed

  13. English in the Czech Republic: Linguists’ perspectives

    Czech Academy of Sciences Publication Activity Database

    Kaderka, Petr; Prošek, Martin

    -, č. 28 (2014), s. 173-198 ISSN 0933-1883 Institutional support: RVO:68378092 Keywords : language situation * English as a global language * attitudes towards English * national language institution * sociolinguistics * Czech Republic Subject RIV: AI - Linguistics

  14. Czech Republic to Become Member of ESO

    Science.gov (United States)

    2006-12-01

    Today, an agreement was signed in Prague between ESO and the Czech Republic, aiming to make the latter become a full member of ESO as of 1 January 2007. "The future membership of the Czech Republic in ESO opens for the Czech astronomers completely new opportunities and possibilities. It will foster this discipline on the highest quality level and open new opportunities for Czech industry to actively cooperate in research and development of high-tech instruments for astronomical research," said Miroslava Kopicová, Minister of Education, Youth and Sports of the Czech Republic. ESO PR Photo 52/06 ESO PR Photo 52/06 Signing Ceremony "We warmly welcome the Czech Republic as the thirteenth member of ESO," said Catherine Cesarsky, ESO's Director General. "The timing couldn't be better chosen: with the Very Large Telescope, Europe is now at the forefront of ground-based astronomy, and with the construction of ALMA and the final studies for the European Extremely Large Telescope, we will ensure that this will remain so for several decades. We look forward to working together with our Czech colleagues towards these successes." The signing event took place at the Czech Ministry of Education, Youth and Sports in Prague. Following ratification by the Czech Parliament, the Czech Republic with thus join the twelve present member states of ESO, the European Organisation for Astronomical Research in the Southern Hemisphere: Belgium, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. The Czech Republic is the first country from Central and Eastern Europe to join ESO. Astronomy in the Czech Republic has a very long tradition that dates from as far back as 3500 BC. Four centuries ago, Tycho Brahe and Johannes Kepler established themselves in Prague at the invitation of the emperor Rudolph II, laying the ground for the first golden age in astronomy. Later, eminent scientists such as Christian Doppler, Ernst Mach and

  15. The Phenomenon of Czech Beer: a review

    Czech Academy of Sciences Publication Activity Database

    Olšovská, J.; Čejka, P.; Sigler, Karel; Hönigová, V.

    2014-01-01

    Roč. 32, č. 4 (2014), s. 309-319 ISSN 1212-1800 Institutional support: RVO:61388971 Keywords : Czech beer * chemical profile * sensorial profile Subject RIV: EE - Microbiology, Virology Impact factor: 0.675, year: 2014

  16. Colonoscopic polypectomy of colorectal polyps in children under general anesthesia.

    Science.gov (United States)

    Lin, Chien-Heng; Wu, Rick Sai-Chuen; Lin, Wei-Ching; Wu, Shu-Fen; Chen, An-Chyi

    2009-02-01

    In many countries, general anesthesia is not routinely used for colonoscopic polypectomy in children because of either feasibility or cost-effectiveness issues. However, we have been using general anesthesia for colonoscopic polypectomy in pediatric patients in our hospital for the past 5 years. The aim of this study was to evaluate the safety of the procedure and the degree of satisfaction that the patients' parents and endoscopists had with the use of general anesthesia. We retrospectively analyzed the results of colonoscopic polypectomies under general anesthesia in 18 patients performed between January 2001 and December 2005. The removed polyps were examined histologically and the patients were observed to assess complications during the first 24-hour postoperative period. The patients' parents' and endoscopists' satisfaction with the use of general anesthesia was surveyed after the procedure. In our patient group, there were 10 boys and eight girls. The mean age was 5.5 +/- 3.4 years (range, 2-15 years). Seventeen of the 18 patients had rectal bleeding (mean duration, 3.7 months) as the main symptom. There were 12 patients with juvenile polyps, four with hyperplastic polyps, one with juvenile polyposis and one with Peutz-Jeghers syndrome. The majority (70.6%) of the polyps were located in the rectosigmoid colon. No significant complications related to colonoscopic polypectomy or anesthesia were observed. Satisfaction among parents and endoscopists ranged from good to excellent. General anesthesia is recommended for pediatric patients undergoing colonoscopic polypectomy.

  17. Colonoscopic Polypectomy of Colorectal Polyps in Children Under General Anesthesia

    Directory of Open Access Journals (Sweden)

    Chien-Heng Lin

    2009-02-01

    Full Text Available In many countries, general anesthesia is not routinely used for colonoscopic polypectomy in children because of either feasibility or cost-effectiveness issues. However, we have been using general anesthesia for colonoscopic polypectomy in pediatric patients in our hospital for the past 5 years. The aim of this study was to evaluate the safety of the procedure and the degree of satisfaction that the patients' parents and endoscopists had with the use of general anesthesia. We retrospectively analyzed the results of colonoscopic polypectomies under general anesthesia in 18 patients performed between January 2001 and December 2005. The removed polyps were examined histologically and the patients were observed to assess complications during the first 24-hour postoperative period. The patients' parents' and endoscopists' satisfaction with the use of general anesthesia was surveyed after the procedure. In our patient group, there were 10 boys and eight girls. The mean age was 5.5 ± 3.4 years (range, 2–15 years. Seventeen of the 18 patients had rectal bleeding (mean duration, 3.7 months as the main symptom. There were 12 patients with juvenile polyps, four with hyperplastic polyps, one with juvenile polyposis and one with Peutz-Jeghers syndrome. The majority (70.6% of the polyps were located in the rectosigmoid colon. No significant complications related to colonoscopic polypectomy or anesthesia were observed. Satisfaction among parents and endoscopists ranged from good to excellent. General anesthesia is recommended for pediatric patients undergoing colonoscopic polypectomy.

  18. Confirmation of the GNB4 gene as causal for Charcot-Marie-Tooth disease by a novel de novo mutation in a Czech patient.

    Science.gov (United States)

    Laššuthová, Petra; Šafka Brožková, Dana; Neupauerová, Jana; Krůtová, Marcela; Mazanec, Radim; Seeman, Pavel

    2017-01-01

    The association of GNB4 with Charcot-Marie-Tooth (CMT) has recently been described in a publication by Soong et al. (Soong, et al., 2013). Here we present a patient with CMT in whom whole exome sequencing identified the mutation p.Lys57Glu in the GNB4 gene (NM_021629.3:c.169A>G). The patient, now 41 years old, is a sporadic case in the family. At the age of 35 he presented with severe disability (CMT neuropathy score 29), profound muscle atrophies, pes cavus and scoliosis. Previously, the patient was tested for PMP22 duplications/deletions and later also with 64 CMT gene panel, with no causal variant found. Subsequently, whole exome sequencing was performed. The p.Lys57Glu in the GNB4 gene was identified as the most probable causal variant, the mutation is not present in the patient's parents, neither in his unaffected sister, therefore we assume that the mutation arose de novo. Taken together, these findings support the causal and pathogenic character of the variant. Our report provides important evidence that GNB4 should become an established CMT gene and our findings confirm the original publication by Soong et al. (2013). Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Healthy Lifestyle of Czech University Students

    OpenAIRE

    Marholdová, Lucie

    2013-01-01

    The thesis deals with the healthy lifestyle of Czech university students. The main objectives are to map the healthy lifestyle of Czech university students, especially to find out whether they follow the principles of healthy lifestyle, to find out their knowledge concerning this issue, to find out if there are any obstacles to follow the healthy lifestyle and to find out whether they know any projects supporting health and healthy lifestyle. In the theoretical part of the thesis the basic te...

  20. Czech Fiscal Policy:Introductory analysis

    OpenAIRE

    Bezděk, Vladimír; Dybczak, Kamil; Krejdl, Aleš

    2003-01-01

    The subject of this work are the following questions: What is the size of quasi-fiscal operations and their impact on the overall fiscal balance and public debt in the Czech Republic? Is the recent increase in Czech fiscal deficits fully attributable to the business cycle, or are there non-cyclical factors in place? And last but not least, what are the long-term perspectives of the fiscal system given the size and speed of the expected population ageing process?

  1. Feedback in Czech Language Courses for Foreigners

    OpenAIRE

    Plísková, Kamila

    2015-01-01

    This thesis explores teacher's feedback, its definition, types, and is specifically focused on feedback moves in context of teaching Czech as a foreign language. The aim of this thesis is to present current research on the feedback in the context of teaching a second/foreign language and describe how the feedback is used in Czech language courses for foreigners and what instruments teachers use for such purpose. The first part is focusing on the feedback as part of the educational dialogue an...

  2. Nuclear - a chance for the Czech Republic

    International Nuclear Information System (INIS)

    Pazdera, F.

    2007-01-01

    The contribution is structured as follows: Physical principles of gaining nuclear energy; Specifics of power generation by nuclear and fossil fuel fired power plants; The nuclear fuel cycle; The potential of nuclear power; Global conflicts of nuclear power plant suppliers; Can power consumption be reduced by energy savings? What is better for the Czech Republic: the carbon tax or the emission trading scheme? In conclusion, the future benefits and requirements are summarized with respect to the Czech Republic. (P.A.)

  3. CLINICAL, EPIDEMIOLOGIC, AND ENDOSCOPIC PROFILE IN CHILDREN AND ADOLESCENTS WITH COLONIC POLYPS IN TWO REFERENCE CENTERS.

    Science.gov (United States)

    Andrade, Denise O; Ferreira, Alexandre Rodrigues; Bittencourt, Paulo Fernando S; Ribeiro, Daniela F P; Silva, Rodrigo Gomes da; Alberti, Luiz Ronaldo

    2015-12-01

    The main goal of this paper is to investigate the frequency, clinical profile, and endoscopic findings of children and teenagers submitted to colonoscopies. Patients of below 18 years of age, diagnosed with polyps by means of colonoscopies at two reference centers of pediatric endoscopy were followed-up between 2002 and 2012. The clinical variables evaluated in this study included: gender, recommendation of colonoscopy, associated signs and symptoms, age of onset of symptoms, age at identification of the polyp, interval of time between the onset of symptoms and the endoscopic diagnosis of colonic polyps, and family history of intestinal polyposis and/or colorectal cancer. The characteristics of the polyps also included: number, morphological type, histology, and distribution. Polyposis syndromes were also investigated. From the 233 patients submitted to colonoscopies, polyps were found in 74 (31.7%) patients, with a median age of 6.6 years, of which 61% were male. Juvenile polyps were identified in 55 (74%) patients, with 7 (9%) characterized within the criteria for juvenile polyposis. Patients with intestinal polyposis syndromes were diagnosed in 35% of the patients. The most frequent clinical presentation was hematochezia. Abdominal pain with acute episodes of intestinal partial obstruction or intussusception with emergency laparotomy was observed in the majority of Peutz-Jeghers syndrome patients leading to an increased morbidity. Even though juvenile colonic polyps are the most frequent type of diagnosed polyps, the present study identified a significant level of children with polyposis syndromes (35%), associated with a higher morbidity of these individuals.

  4. Is colonoscopy necessary in children suspected of having colonic polyps?

    Science.gov (United States)

    Lee, Hye Jin; Lee, Ji Hyuk; Lee, Jong Seung; Choe, Yon Ho

    2010-09-01

    The clinical spectrum, histology, and endoscopic features of colonic polyps in the pediatric age group were studied to evaluate the role of colonoscopy in children suspected of having colonic polyps. Seventy-six patients with colorectal polyps were studied. Investigations included barium enema (n=6), sigmoidoscopy (n=17), and colonoscopy (n=53) at the initial visit. Colonoscopy was also performed in 23 patients who received barium enema or sigmoidoscopy. Data related to age, gender, family history, signs, symptoms, size, location, polyp types, and associated diseases were collected and analyzed. Among the 76 patients, juvenile polyps were detected in 58 (76.3%), potentially premalignant polyposis in 17 (22.4%), familial adenomatous polyposis in 11 (14.5%), Peutz-Jegher syndrome in 4 (5.3%), and juvenile polyposis syndrome in 2 (2.6%). Twenty-two patients (28.9%) had polyps in the upper colon. All patients with potentially malignant polyps had polyps in both the upper colon and rectosigmoid colon. Although most of the children with colorectal polyps had juvenile polyps, a significant number of cases showed multiple premalignant and proximally located polyps. This finding emphasizes the need for a colonoscopy in such patients. Thus, the risk of malignant change, particularly in children with multiple polyps, makes surveillance colonoscopy necessary.

  5. Molecular cytogenetic analyses of hTERC (3q26) and MYC (8q24) genes amplifications in correlation with oncogenic human papillomavirus infection in Czech patients with cervical intraepithelial neoplasia and cervical carcinomas.

    Science.gov (United States)

    Kuglik, P; Kasikova, K; Smetana, J; Vallova, V; Lastuvkova, A; Moukova, L; Cvanova, M; Brozova, L

    2015-01-01

    It is known that cervical cancer develop from precancerous intraepithelial neoplasia (CIN) which is characterized by series of genetic abnormalities. The progression of CIN to cervical carcinoma has been associated especially with the genomic integration of oncogenic human papilloma virus (HPV) and gain of the human telomerase RNA gene hTERC (3q26) and MYC (8q24). In this study, cytology specimens of cervical intraepithelial neoplasia and cervical carcinoma from 74 Czech women were analyzed using the triple-color Cervical FISH Probe Kit designed for identification of HPV infected cells and copy number aberration of the hTERC and MYC genes. HPV-positivity exhibited 70% of patients with premalignant lesions (CIN I - CIN III, carcinoma in situ), chromosomal changes were found in 53.3% of cases - MYC amplification had 33.3% of women with CIN I - CIN III and 50% with carcinoma in situ. Amplification of hTERC was detected in 16.7% of patient with CIN I, in 50% with CIN II, in 58.3% with CIN III and in 66.7% with carcinoma in situ. Based on HPV-positivity and the occurrence of chromosomal aberrations, patients were divided into high-, intermediate- and low-risk group. Among women with cervical carcinomas, HPV infection was detected in 90.1% of specimens and chromosomal aberrations were found in 87.5% of samples. Amplification of MYC gene was detected in 25% and hTERC gene in 62.5% of patients. According to the histopathological grade of tumors, MYC gene amplification occurred more frequently in specimens of spinocellular carcinoma than adenocarcinoma (p=0.029). We found no association between the frequency of cytogenetic lesions and the incidence of lymphangiogenesis or lymph node metastases in cervical carcinoma patients. Simultaneous hTERC and MYC genes amplification was significantly more frequent in samples of cervical carcinomas than in premalignant lesions (p=0.008).In a cohort of 26 patients with cervical carcinoma we used oligo-based GGH+SNP microarray

  6. Hamartomatous polyps - a clinical and molecular genetic study.

    Science.gov (United States)

    Jelsig, Anne Marie

    2016-08-01

    Hamartomatous polyps (HPs) in the gastrointestinal (GI) tract are rare compared to other types of GI polyps, yet they are the most common type of polyp in children. The symptoms are usually rectal bleeding, abdominal pain, obstipation, anaemia, and/or small bowel obstruction. The polyps are typically removed concurrently with endoscopy when located in the colon, rectum, or stomach, whereas polyps in the small bowel are removed during push-enteroscopy, device-assisted enteroscopy, or by surgery. HPs can be classified as juvenile polyps or Peutz-Jeghers polyps based on their histopathological appearance. Patients with one or a few juvenile polyps are usually not offered clinical follow-up as the polyp(s) are considered not to harbour any malignant potential. Nevertheless, it is important to note that juvenile polyps and HPs are also found in patients with hereditary hamartomatous polyposis syndromes (HPS). Patients with HPS have an increased risk of cancer, recurrences of polyps, and extraintestinal complications. The syndromes are important to diagnose, as patients should be offered surveillance from childhood or early adolescence. The syndromes include juvenile polyposis syndrome, Peutz-Jeghers syndrome, and the PTEN hamartoma tumour syndrome. Currently, the HPS diagnoses are based on clinical criteria and are often assisted with genetic testing as candidate genes have been described for each syndrome. This thesis is based on six scientific papers. The overall aim of the studies was to expand the knowledge on clinical course and molecular genetics in patients with HPs and HPS, and to investigate research participants' attitude towards the results of extensive genetic testing.   Paper I: In the first paper we investigated the occurrence, anatomic distribution, and other demographics of juvenile polyps in the colon and rectum in Denmark in 1995-2014. Based on the Danish Pathology Data Bank we found that 1772 patients had 2108 JPs examined in the period, and we

  7. Content validation of the nursing diagnosis acute pain in the Czech Republic and Slovakia.

    Science.gov (United States)

    Zeleníková, Renáta; Žiaková, Katarína; Čáp, Juraj; Jarošová, Darja

    2014-10-01

    The main purpose of the study was to validate the defining characteristics of the nursing diagnosis acute pain in the Czech Republic and Slovakia. This is a descriptive study. The validation process involved was based on Fehring's diagnostic content validity model. Four defining characteristics were classified as major by Slovak nurses and eight defining characteristics were classified as major by Czech nurses. Validation of the nursing diagnosis acute pain in the Czech and Slovak sociocultural context has shown that nurses prioritize characteristics that are behavioral in nature as well as patients' verbal reports of pain. Verbal reports of pain and behavioral indicators are important for arriving at the nursing diagnosis acute pain. © 2014 NANDA International, Inc.

  8. Land use and ownership and the Czech farm development

    OpenAIRE

    Doucha, Tomas; Divila, Emil; Fischer, Michal

    2005-01-01

    Characteristics of the present land usage, land ownership and the land market in the Czech Republic — the distribution of the Czech Utilised Agricultural Area (UAA) among owners and users, driving barriers on the Czech Land market. A regional view on the Czech UAA from the points of view of natural conditions, agro-environmental and rural sensitivity. Definition of policy scenarios for the 2013 horizon with the respect of coupled/decoupled direct payments, LFA payments, legislation related ...

  9. Research of football popularity in the Czech Republic

    OpenAIRE

    Hrabětová, Michaela

    2011-01-01

    Title: Research of football popularity in the Czech republic Objectives: The aim is to determine the public attitude to football, and public opinion on the football competitions. I own contribution will be recommendations for the Football Asocciation of the Czech republic, clubs and media, that could help increase interest in football. Methods: For questioning the Czech public a method of the German marketing agency UFA Sports Hamburg was used and adjusted for Czech conditions. A method of el...

  10. Organic food market in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Iva Živělová

    2013-01-01

    Full Text Available The contribution provides partial results of the research focused on organic food, a product from organic farming. The total area of ecologically farmed areas in the Czech Republic permanently increases, however the offer of organic food is insufficient, in particular in view of their structure. Deficiency in organic food is being solved by imports. Distributors play an important role in the organic food market. In the Czech Republic the largest share from them is occupied by retail chains. Their share continues to grow to the detriment of other sales channels. One of the main factors affecting consumers’ interest in organic food is its price. The comparison of organic food prices and prices of conventional food in the selected retail chains, Globus Czech Republic, limited partnership, SPAR Czech business company Pte., Tesco Stores CZ JSC, AHOLD Czech Republic JSC, BILLA Pte., and in organic food and healthy nutrition stores showed significantly higher prices. The smallest difference in prices can be monitored in the milk and milk products. On the contrary, the largest difference is in fruits, vegetables, eggs and jams. However, the consumers’ awareness of organic food quality is at the same time increasing and the consumers are willing to pay for them a higher price.

  11. Partnership for nuclear power in the Czech Republic

    International Nuclear Information System (INIS)

    1995-01-01

    A catalogue is presented of 27 organizations involved in the Czech nuclear programme. Characteristics and addresses are given of the Czech electrical utility, plant and component manufacturers, the uranium mining company, design and engineering companies, research establishments, and consulting companies. Some foreign companies with activities in the Czech Republic are also dealt with. (J.B.)

  12. A Simple Czech and English Probabilistic Tagger: A Comparison.

    Science.gov (United States)

    Hladka, Barbora; Hajic, Jan

    An experiment compared the tagging of two languages: Czech, a highly inflected language with a high degree of ambiguity, and English. For Czech, the corpus was one gathered in the 1970s at the Czechoslovak Academy of Sciences; for English, it was the Wall Street Journal corpus. Results indicate 81.53 percent accuracy for Czech and 96.83 percent…

  13. Decision for surgery in the management of a rare condition, childhood gallbladder polyps, and the role of ultrasonography.

    Science.gov (United States)

    Bayram Kabaçam, Gülşah; Akbıyık, Fatih; Livanelioğlu, Ziya; Tiryaki, H Tuğrul; Karakuş, Esra; Kabaçam, Gökhan

    2013-01-01

    Gallbladder polyps are tumors or tumor-like protrusions of the gallbladder. They are rarely seen in the pediatric age. Most important issue about these mostly incidental lesions is the risk of malignant transformation. Size more than 10 mm is the classicalcutoff for determining this risk, but it is rarely valid in children. Ultrasonography is the method of choice for follow-up, but it rarely demonstrates change of size or malignant transformation. Hereby, we report 6 cases of childhood gallbladder polyps, none of which had a genetic risk factor. Follow-up was uneventful in 4 of them. Two patients had undergone surgery, but none of the lesions were neoplastic. In the follow-up, a single experienced radiologist should handle the patient, in order to prevent inter-observer variation. The cut-off size for deciding surgery should be 10 mm for those cases with genetic background creating malignancy risk (metachromatic leukodystrophy, pancreaticobiliary duct abnormalities, achondroplasia, Peutz-Jeghers syndrome) or with accompanying cholelithiasis, and 15 mm for those without any risk factors to prevent any unnecessary operations.

  14. Prader-Willi Syndrome due to an Unbalanced de novo Translocation t(15;19)(q12;p13.3).

    Science.gov (United States)

    Dang, Vy; Surampalli, Abhilasha; Manzardo, Ann M; Youn, Stephanie; Butler, Merlin G; Gold, June-Anne; Kimonis, Virginia E

    2016-01-01

    Prader-Willi syndrome (PWS) is a complex, multisystem genetic disorder characterized by endocrine, neurologic, and behavioral abnormalities. We report the first case of an unbalanced de novo reciprocal translocation of chromosomes 15 and 19, 45,XY,-15,der(19)t(15;19)(q12;p13.3), resulting in monosomy for the PWS critical chromosome region. Our patient had several typical features of PWS including infantile hypotonia, a poor suck and feeding difficulties, tantrums, skin picking, compulsions, small hands and feet, and food seeking, but not hypopigmentation, a micropenis, cryptorchidism or obesity as common findings seen in PWS at the time of examination at 6 years of age. He had seizures noted from 1 to 3 years of age and marked cognitive delay. High-resolution SNP microarray analysis identified an atypical PWS type I deletion in chromosome 15 involving the proximal breakpoint BP1. The deletion extended beyond the GABRB3 gene but was proximal to the usual distal breakpoint (BP3) within the 15q11q13 region, and GABRA5, GABRG3, and OCA2 genes were intact. No deletion of band 19p13.3 was detected; therefore, the patient was not at an increased risk of tumors from the Peutz-Jeghers syndrome associated with a deletion of the STK11 gene. © 2016 S. Karger AG, Basel.

  15. Experiences of the first PICC team in the Czech Republic.

    Science.gov (United States)

    Lisova, Katerina; Paulinova, Vendula; Zemanova, Katerina; Hromadkova, Jaroslava

    The first specialist nursing team placing peripherally inserted central catheters (PICCs) in the Czech Republic was established in September 2012. During 2013 the team placed 167 PICCs and 162 midline catheters. In another 6 patients the insertion was not successful. PICCs were inserted mainly for oncology patients; while midline catheters were inserted for patients admitted to general wards. Average duration of catheter insertion was 91 days (range 7-285 days) for PICCs and 14 days (range 2-40 days) for midline catheters. During follow up of PICCs, catheter infection rate was 0.3/1000 days, vein thrombosis rate 0.4/1000 days, catheter occlusion 0.4/1000 days, and catheter displacement 0.33/1000 days. For midline catheters infection rate was 1.4/1000 days, vein thrombosis 5.2/1000 days, catheter occlusion 2.6/1000 days, and catheter displacement 2.2/1000 days. The authors hope that these results will motivate other hospitals in the Czech republic to establish PICC teams, as in other European countries.

  16. Czech young generation activities in nuclear training and education framework in the Czech Republic

    Energy Technology Data Exchange (ETDEWEB)

    Matejkova, J.; Foral, S.; Varmuza, J.; Katovsky, K.

    2014-07-01

    The Czech Republic has a long tradition in nuclear power production. One third of Czech electricity production is generated in two nuclear power plants, Dukovany and Temelin, totaling six power reactors. There are also three non-power, research reactors: two zero power reactors for education and research support, and one material testing reactor (MTR) used mainly for radioisotopes production. One of zero power reactors is employed by the Czech Technical University in Prague for education and research purposes, other zero power reactor and MTR are situated at nuclear research complex in Rez. (Author)

  17. Early Warning Network of The Czech Republic

    International Nuclear Information System (INIS)

    The Early Warning Network, part of the Radiation Monitoring Network of The Czech Republic, has been established after 1990 to provide overview information about radiation situation across the territory of Czech Republic and to raise an alarm in case of unreported accident outside the territory of Czech Republic. The Early Warning Network measuring sites are equipped with two-probe system. As a result of combination of a low-range probe (proportional counter, dose-rate range 10-8 to 10-3 Sv/h) and a high-range probe (Geiger-Mueller counter, 10-5 to 1 Sv/h) the system is able to cover the dose-rate range from natural background to values in real emergency situation. The energy range covered is 20 keV to 2 MeV and 55 keV to 2 MeV, respectively

  18. Quantum GIS plugin for Czech cadastral data

    Directory of Open Access Journals (Sweden)

    Anna Kratochvílová

    2012-10-01

    Full Text Available This paper presents new Quantum GIS plugin for Czech cadastral data and its development. QGIS is a rapidly developing cross-platform desktop Geographic Information System (GIS released under the GNU GPL. QGIS is written in C++, and uses the Qt library. The plugin is developed in C++, too. The new plugin can work with Czech cadastral data in the new Czech cadastral exchange data format called VFK (or NVF. Data are accessed through VFK driver of the OGR library. The plugin should facilitate the work with cadastral data by easy search and presenting well arranged information. Information is displayed in the way similar to web applications, thus the control is friendly and familiar for users. The plugin supports interaction with map using QGIS functionality and it is able to export various cadastral reports. This paper provides ideas which can be generalized to develop QGIS plugin dealing with specific data.

  19. Genetic health in Czech cattle population

    Directory of Open Access Journals (Sweden)

    Jindřich Čítek

    2016-09-01

    Full Text Available The paper sums up the studies done in the cattle population in the Czech Republic, concerning the genetic health. As for the congenital defects, umbilical hernia was the most frequently noted disorder. In the 90´s, BLAD became a serious problem in the Czech cattle population. However, strict measures have been efficient, and the frequency of heterozygous sires decreased rapidly. The approach to CVM was not consistent enough, and therefore the decrease was somewhat slow. The recessive alleles of bovine citrullinaemia, DUMPS, glycogen storage disease V and II, and factor XI deficiency were not found. Further, the cytogenetic analysis was done. Robertsonian tranclocation affected 0.50 % of Czech Simmentals, and 3.57 % of beef sires, the Holsteins were not affected. Autosomal aneuploidies were not found, and 2.3 % beef animals carried gonosomal triploidy.

  20. Family Enterprise in Czech Civil Code

    Directory of Open Access Journals (Sweden)

    Janku Martin

    2016-12-01

    Full Text Available For more than two decades the family business enterprises of the first generation (generation of founders are more and more dominating in the category of today’s small and medium–sized enterprises in the Czech Republic. The necessary legal background defining the legal relationships and rights of all participating persons was, however, limited to general provisions in the Commercial Code that has not solved many of the problems associated thereto. Only in 2012 the new Czech Civil Code, Act. No 89/2012 Coll., introduced the institute of family enterprise as completely new term in the Czech Civil law. The presented paper aims to analyse the key rules of this new legal regulation, focusing on significant aspects of the institute in the context of commercial law and family law, as well as, to highlight the potential weaknesses and gaps existing in the regulation.

  1. Highly qualified in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Renata Čuhlová

    2017-05-01

    Full Text Available The paper aims to analyse the current situation of the highly qualified in the Czech Republic applying the ISCO qualification. Previous studies suggest that educational attainment has an important impact on labour market performance and national competitiveness. Data analyses approved that highly qualified workforce positively influences economic situation of the EU–15 Member States they work in. However, this hypothesis was disapproved for the EU–10+3 Member States joining the EU after 2004. The difference can be explained by the various stage in convergence process since some New Member States are still in transformation period. We positively appraise the significant growth of fraction of the highly qualified in the Czech Republic since 2004, especially in the major group Professionals involving the most qualified workforce. The same trend happened also for the highly qualified foreigners in the Czech Republic, however their attracting still remains a challenge.

  2. Social Tourism Support in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Kouřilová Jana

    2014-12-01

    Full Text Available Social tourism is a form of tourism that takes into account the participation of physically or socially handicapped individuals, and at the same time the social tourism activities are in accordance with the environmental sustain-ability of the territory. in the czech republic the social tourism has been supported at the national level since 2010 by the National tourism support Programme. this paper is aimed at the evaluation of social tourism support in the czech republic in the period of 2010-2012. The evaluation is performed by regions and target groups (families with children, young people under 26 years, seniors and the disabled. the other aim is to identify which model of social tourism was implemented in the czech republic during the period of 2010-2012.

  3. Transfer pricing and the Czech tax policy

    Directory of Open Access Journals (Sweden)

    Veronika Solilová

    2010-01-01

    Full Text Available The Czech Republic as a small open economy with an extensive network of the international tax treaties for the avoidance of the double taxation prevents from shifting the tax base of the associated enterprises to countries with preferential tax regime through transfer pricing rules. Transfer pricing as one of the important areas of international taxes determines how the profits of the multinational enterprises are split between the jurisdictions in which they operate and which countries get to tax those profits. This situation may affect the global budget of the multinational enterprises and the tax reve­nues of the jurisdictions. This paper is focused on the transfer pricing rules used in the Czech Republic and makes recommendations for the Czech tax policy in this area based on the analysis of the transfer pricing rules in the EU Member States.

  4. Liver Kinase B1 (LKB1) in the Pathogenesis of UVB-induced Murine Basal Cell Carcinoma

    Science.gov (United States)

    Byekova, Yevgeniya A.; Herrmann, Jennifer L.; Xu, Jianmin; Elmets, Craig A.; Athar, Mohammad

    2011-01-01

    LKB1, a known tumor suppressor, is mutated in Peutz-Jeghers Syndrome (PJS). It is responsible for the enhanced cancer risk in patients with PJS. Dysregulation of LKB1-dependent signaling also occurs in various epithelial cancers. UVB alters the expression of LKB1, though its role in the pathogenesis of skin cancer is unknown. Here we describe upregulation of LKB1 expression in UVB-induced murine basal cell carcinoma (BCC) and in human skin tumor keratinocytes. AMP-kinase and acetyl Co-A carboxylase, the downstream LKB1 targets, are also enhanced in this neoplasm. In addition, p-Akt, a kinase which inactivates GSK3β by its phosphorylation, is enhanced in BCCs. Consistently, an accumulation of p-GSK3β and an increase in activated nuclear β-catenin are found. mTOR signaling, which is also inhibited by LKB1, remains upregulated in BCCs. However, a marked decrease in the expression of sestrins, which function as potent negative regulators of mTOR is observed. Metformin, a known chemical inducer of this pathway, was found effective in immortalized HaCaT keratinocytes, but failed to activate the LKB1-dependent signaling in human carcinoma A431 cells. Thus, our data show that the LKB1/AMPK axis fails to regulate mTOR pathway, and a complex regulatory mechanism exists for the persistent mTOR activation in murine BCCs. PMID:21272562

  5. Colorectal polyps in childhood.

    Science.gov (United States)

    Thakkar, Kalpesh; Fishman, Douglas S; Gilger, Mark A

    2012-10-01

    Colorectal polyps are a common cause of gastrointestinal bleeding in children. This review updates the information on colorectal polyps and summarizes the recent advances in genetics, diagnosis, and treatment of polyps in the large intestine. A review of recent literature regarding colorectal polyps demonstrates an estimated detected prevalence of 6.1% overall and 12.0% among those with lower gastrointestinal bleeding during pediatric colonoscopy. Non-Caucasian races (e.g., black and Hispanic) are at higher risk for colorectal polyps in childhood. Recent data show juvenile polyps may recur in approximately 45% of children with multiple polyps and 17% of children with solitary polyps. A clinical trial showed that celecoxib, a cyclooxygenase (COX)-2 inhibitor, significantly reduced the number of colorectal polyps in children with familial adenomatous polyposis (FAP). Ethical challenges related to genetic tests for FAP have been newly examined. The utility of novel endoscopic techniques (e.g., enteroscopy) in Peutz-Jeghers Syndrome to prevent intussusception have been newly described. Although colorectal polyps in children are generally benign and easily removed, careful clinical evaluation and ongoing research are needed to identify the small proportion of children at risk for cancer. The current paradigm of using the polyp number at presentation as a primary determinant of subsequent surveillance may be inadequate for many patients.

  6. The differentiation and prognostic implication of the solitary colonic polyp and the polyposis syndromes: A radiologic, histologic, and pathologic approach

    International Nuclear Information System (INIS)

    Olmsted, W.W.; Lichtenstein, J.E.

    1987-01-01

    The differential diagnosis of the solitary colonic polyp and the implications and prognostic significance of the solitary colonic polyp and the polyposis syndromes are frequently confusing because of imprecise and overlapping terminology. Such confusion may lead to misdiagnosis or overdiagnosis and improper patient treatment and surveillance. In the first part of this course, basic terms are defined to acquaint all participants with current common ground. The most frequently occurring solitary polyps (e.g., the colonic adenoma, hyperplastic polyp, Peutz-Jeghers hamartoma, juvenile hamartoma, and inflammatory polyp) are illustrated in detail with radiologic-histologic-pathologic correlation. The prognostic significance of each type of lesion and a scheme for proper colonic surveillance is discussed. In the second part of the session, there is a thorough discussion of multiple colonic polyps and the polyposis syndromes. Radiologic-pathologic correlation are used to illustrate these entities, and therapeutic and diagnostic implications are thoroughly covered. The differential diagnosis of the polyposis syndromes, including lymphoid abnormalities, pneumatosis intestinalis, and colitis cystica profunda, are mentioned. The participant should expect to gain a full understanding of the solitary and multiple colonic polyp states and algorithms for prognosis and treatment

  7. Guideline for wireless capsule endoscopy in children and adolescents: A consensus document by the SEGHNP (Spanish Society for Pediatric Gastroenterology, Hepatology, and Nutrition) and the SEPD (Spanish Society for Digestive Diseases).

    Science.gov (United States)

    Argüelles-Arias, Federico; Donat, Ester; Fernández-Urien, Ignacio; Alberca, Fernando; Argüelles-Martín, Federico; Martínez, María José; Molina, Manuel; Varea, Vicente; Herrerías-Gutiérrez, Juan Manuel; Ribes-Koninckx, Carmen

    2015-12-01

    Capsule Endoscopy (CE) in children has limitations based mainly on age. The objective of this consensus was reviewing the scientific evidence. Some experts from the Spanish Society of Gastroenterology (SEPD) and Spanish Society for Pediatric Gastroenterology, Hepatology, and Nutrition (SEGHNP) were invited to answer different issues about CE in children. These sections were: a) Indications, contraindications and limitations; b) efficacy of CE in different clinical scenarios; c) CE performance; d) CE-related complications; e) Patency Capsule; and f) colon capsule endoscopy. They reviewed relevant questions on each topic. The main indication is Crohn's disease (CD). There is no contraindication for the age and in the event that the patient not to swallow it, it should be administered under deep sedation with endoscopy and specific device. The CE is useful in CD, for the management of OGIB in children and in Peutz-Jeghers syndrome (in this indication has the most effectiveness). The main complication is retention, which should be specially taken into account in cases of CD already diagnosed with malnutrition. A preparation regimen based on a low volume of polyethylene glycol (PEG) the day before plus simethicone on the same day is the best one in terms of cleanliness although does not improve the results of the CE procedure. CE is safe and useful in children. Indications are similar to those of adults, the main one is CD to establish both a diagnosis and disease extension. Moreover, only few limitations are detected in children.

  8. Guideline for wireless capsule endoscopy in children and adolescents: a consensus document by the SEGHNP (Spanish Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the SEPD (Spanish Society for Digestive Diseases

    Directory of Open Access Journals (Sweden)

    Federico Argüelles-Arias

    2015-12-01

    Full Text Available Introduction: Capsule endoscopy (CE in children has limitations based mainly on age. The objective of this consensus was reviewing the scientific evidence. Material and methods: Some experts from the Spanish Society of Gastroenterology (SEPD and Spanish Society for Pediatric Gastroenterology, Hepatology, and Nutrition (SEGHNP were invited to answer different issues about CE in children. These sections were: a Indications, contraindications and limitations; b efficacy of CE in different clinical scenarios; c CE performance; d CE-related complications; e Patency capsule; and f colon capsule endoscopy. They reviewed relevant questions on each topic. Results: The main indication is Crohn's disease (CD. There is no contraindication for the age and in the event that the patient not to swallow it, it should be administered under deep sedation with endoscopy and specific device. The CE is useful in CD, for the management of OGIB in children and in Peutz-Jeghers syndrome (in this indication has the most effectiveness. The main complication is retention, which should be specially taken into account in cases of CD already diagnosed with malnutrition. A preparation regimen based on a low volume of polyethylene glycol (PEG the day before plus simethicone on the same day is the best one in terms of cleanliness although does not improve the results of the CE procedure. Conclusions: CE is safe and useful in children. Indications are similar to those of adults, the main one is CD to establish both a diagnosis and disease extension. Moreover, only few limitations are detected in children.

  9. The case of the Czech Republic

    Directory of Open Access Journals (Sweden)

    2004-04-01

    Full Text Available Since the collapse of the socialist system at the beginning of the 1990s, the health situation in the Czech Republic has improved more rapidly than in other CEE countries. Mortality from circulatory diseases decreased significantly at higher ages. The recent decline in mortality is likely to be attributable to technical progress in medical treatment and less affected by the change in lifestyle. While the use of cardiovascular drugs and the number of operations of invasive heart-surgery considerably improved, smoking and alcohol consumption have somewhat augmented at the same time. The recent favourable turnover has currently brought the Czech Republic a little closer to the European average.

  10. Market survey Czech Republic. Bio-energy

    International Nuclear Information System (INIS)

    2008-01-01

    Basic characteristics of the market for bioenergy (biomass, biogas and biofuels) in the Czech Republic and consequences for business environment are summarized, based on a SWOT analysis. The Czech biomass market is still developing and is segmented and disintegrated to many regional or sector markets where also prices of biomass differ significantly and could be affected by dominant players. There were several attempts to establish a kind of biomass exchange, but were unsuccessful. The biomass trade is done usually on bilateral basis but without clear long-term agreements on contracts which would secure stable supply and prices

  11. Early warning network of the Czech Republic

    International Nuclear Information System (INIS)

    The Early Warning Network encompasses 48 measuring sites covering the whole territory of the Czech Republic; 38 of them are located at observatories of the Czech Hydro-Meteorological Institute (28 at round-the-clock manned observatories, 10 at unmanned, automated observatories) and 10 are located at air contamination measuring points operated by the National Radiation Protection Institute and Regional Centres of the State Office for Nuclear Safety. The network operates in one of 3 modes: the standard mode, alert mode, and emergency mode. (P.A.)

  12. Country policy profile - Czech Republic. February 2015

    International Nuclear Information System (INIS)

    2015-02-01

    In the Czech Republic, RES electricity is supported through FITs and FIPs called green bonus. Plant operators can choose between these two options. RES heat is generally supported through subsidies; however, the subsidy cohesion program for the programming period 2014-2020 has not been adopted jet. A very important incentive is an Exemption from Real Estate Tax. Currently, the Czech Republic has only introduced a building obligation for the use of renewable heating and the exemplary role of public authorities. The main incentive for renewable energy use in transport is a quota system. bio-fuels are exempt from consumption tax

  13. Country policy profile - Czech Republic. December 2015

    International Nuclear Information System (INIS)

    2015-12-01

    In the Czech Republic, RES electricity is supported through FITs and FIPs called green bonus. Plant operators can choose between these two options. RES heat is generally supported through subsidies; however, the subsidy cohesion program for the programming period 2014-2020 has not been adopted jet. A very important incentive is an Exemption from Real Estate Tax. Currently, the Czech Republic has only introduced a building obligation for the use of renewable heating and the exemplary role of public authorities. The main incentive for renewable energy use in transport is a quota system. bio-fuels are exempt from consumption tax

  14. Tobacco Cessation Practices and Attitudes Among Nurses in the Czech Republic.

    Science.gov (United States)

    Sarna, Linda P; Bialous, Stella Aguinaga; Králíková, Eva; Kmetova, Alexandra; Felbrová, Vladislava; Kulovaná, Stanislava; Malá, Katerina; Roubíčková, Eva; Wells, Marjorie J; Brook, Jenny K

    2015-01-01

    Tobacco is the leading cause of cancer in the Czech Republic. More than one-third of the population older than 15 years smokes, including many nurses. Most smokers want to quit, but the extent of nurses' involvement in tobacco cessation is unknown. The purposes of this study are to describe the frequency of nurses' interventions in helping smokers quit, examine their attitudes and skills, and explore the relationship of nurses' smoking status to level of intervention. A convenience sample of nurses in the Czech Republic completed a survey about their frequency of interventions according to the 5As for tobacco dependence treatment (i.e., ask, advise, assess, assist, arrange), their attitudes and perceived skills, and their smoking status (never, former, current). A total of 157 nurses completed the survey; 26% "always" or "usually" assisted patients with smoking cessation. Few (22%) reported that nurses could play an important role in helping patients quit, and 65% rated their ability to help smokers quit as "fair/poor." Nurse who smoked (30%) were less likely to consistently assess smoking status or arrange for follow-up support. Few nurses in the Czech Republic consistently provide smoking cessation support to patients, have the skills to do so, or view this role as an important part of their role. To reduce tobacco-related cancers in the Czech Republic, capacity-building efforts are needed to enhance nurses' skills and confidence in providing smoking cessation interventions. Support is also need to help nurses who smoke quit.

  15. Pricing and reimbursement of pharmaceuticals in the Czech Republic and Sweden.

    Science.gov (United States)

    Davidova, Jana; Praznovcova, Lenka; Lundborg, Cecilia Stålsby

    2008-01-01

    To describe and compare price regulation and reimbursement in the Czech Republic and Sweden. Legal documents, government reports, statutory information, annual reports and scientific articles were searched using the keywords: pharmaceutical market regulation, drug policy, drug pricing, drug reimbursement and patients' participation in costs concerning both countries. Approaches to regulation and regulatory steps concerning prices were compared between the countries. (i) Institutional responsibilities in pricing and reimbursement of pharmaceuticals; (ii) principles of patients' participation in costs on pharmaceuticals. Substantial differences were found in terms of pricing. In the Czech Republic, the Ministry of Finance sets maximal prices for pharmaceuticals whereas in Sweden there is a process of price regulation combined with reimbursement decisions taken by the Pharmaceutical Benefits Board. Together with a system of state-owned pharmacies, this ensures that drug prices in Sweden are fixed at the same level throughout the country. In the Czech Republic, prices may differ, since only maximal price levels are set. In both countries, decisions about reimbursement are taken at the national or state level whereas insurance funds or county councils are responsible for covering costs. The private share of pharmaceutical expenditures is substantially lower in the Czech Republic, even though there is no maximal level for patient's co-payment, as there is in Sweden. Differences in price setting and some other regulations of the pharmaceutical market were found. Both systems are designed to promote rational use of pharmaceuticals; and are based on social solidarity.

  16. Czech female managers and their wages

    Czech Academy of Sciences Publication Activity Database

    Jurajda, Štěpán; Paligorova, T.

    2009-01-01

    Roč. 16, č. 3 (2009), s. 342-351 ISSN 0927-5371 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : gender wage gap * managers * Czech Republic Subject RIV: AH - Economics Impact factor: 0.992, year: 2009

  17. Urban public spaces in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Kratochvíl, Petr

    2013-01-01

    Roč. 37, č. 3 (2013), s. 173-181 ISSN 2029-7955 R&D Projects: GA ČR(CZ) GAP409/11/2220 Institutional support: RVO:68378033 Keywords : public space * town planning * contemporary Czech architecture Subject RIV: AL - Art, Architecture, Cultural Heritage

  18. Alternative energy sources in the Czech Republic

    International Nuclear Information System (INIS)

    1999-10-01

    The hereby presented report was elaborated for the Royal Netherlands Embassy in Prague, Czech Republic by the Netherlands Chamber of Commerce in Prague from July to October 1999. The report is constituted so as to provide a complete introductory overview of the situation in the Czech Republic relating to alternative energy sources. For the purposes of this report, the term alternative energy sources is conceived as renewable energy sources and combined generation of heat and electricity. Renewable energy sources comprise sun, water, wind, geothermal energy and energy generated from biomass or waste. The report features a glimpse at the history of alternative energy sources' utilisation in the Czech Republic, a description of the current state and an extrapolation of existing trends into expectable medium- and long-run developments. The report also includes an insight into the relevant legal framework and a general scan of market opportunities. The objective of the report is to prepare a solid starting platform for Dutch companies which specialise in renewable energy sources and/or cogeneration and which may be interested in extending their scope of activities to the Czech Republic

  19. Regional identities of Czech historical lands

    Czech Academy of Sciences Publication Activity Database

    Vaishar, Antonín; Zapletalová, Jana

    2016-01-01

    Roč. 65, č. 1 (2016), s. 15-25 ISSN 2064-5031 Institutional support: RVO:68145535 Keywords : regional identity * administrative division * historical lands * Bohemia * Moravia - Czech Republic Subject RIV: DE - Earth Magnetism, Geodesy, Geography http://www.mtafki.hu/konyvtar/kiadv/HunGeoBull2016/HunGeoBull_65_1_2.pdf

  20. Grids and clouds in the Czech NGI

    Science.gov (United States)

    Kundrát, Jan; Adam, Martin; Adamová, Dagmar; Chudoba, Jiří; Kouba, Tomáš; Lokajíček, Miloš; Mikula, Alexandr; Říkal, Václav; Švec, Jan; Vohnout, Rudolf

    2016-09-01

    There are several infrastructure operators within the Czech Republic NGI (National Grid Initiative) which provide users with access to high-performance computing facilities over a grid and cloud interface. This article focuses on those where the primary author has personal first-hand experience. We cover some operational issues as well as the history of these facilities.

  1. Forensic Psychology in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Polišenská, Veronika

    2007-01-01

    Roč. 44, č. 1 (2007), s. 55-67 ISSN 1544-4759 R&D Projects: GA ČR(CZ) GA406/07/0261 Institutional research plan: CEZ:AV0Z70250504 Keywords : forensic psychology * Czech Republic * institutions Subject RIV: AN - Psychology

  2. Uranium mining in the Czech Republic

    International Nuclear Information System (INIS)

    Michalek, B.; Babka, O.; Grmela, A.

    2010-01-01

    Until the mid-nineties of the last century, uranium mining belonged to important industries in the Czech Republic and, the Czech Republic occupied a leading position in the world in the production of uranium concentrate. A considerable phasing out of this industry in the first half of the nineties in the last century led to the closure of almost all underground uranium mines; at present they are decommissioned and flooded. Mining operations are performed in only one underground mine in the deposit of Rozna with the expected cessation of mining by the year 2015. The present-day home production of uranium meets only 45% of the demand of the Czech nuclear power industry and is secured from three sources, namely from the production of the deposit of Rozna, from the treatment of mine waters flowing from closed underground uranium mines and from the remediation of the rock environment of the deposit of Straz. With the proven reserves of more than 100,000 t of natural uranium not mined at present, the Czech Republic still represents a potentially significant uranium producer. (author)

  3. Czech, Slovak science ten years after split

    CERN Multimedia

    2003-01-01

    Ten years after the split of Czechoslovakia Czech and Slovak science are facing the same difficulties: shortage of money for research, poor salaries, obsolete equipment and brain drain, especially of the young, according to a feature in the Daily Lidove Noviny (1 page).

  4. Business judgement rule in Czech Corporations Act

    Directory of Open Access Journals (Sweden)

    Jaromír KOŽIAK

    2013-12-01

    Full Text Available Czech private law is currently undergoing a thorough transformation. This inclundes adoption of a brand new Corporations Act, which is to supersede the current Commercial Code. The new legislation introduces several new rules governing liability of company executive officers. One of these is business judgment rule. It should provide company executive officers with a certain level of protection against litigantion – if specific terms are met, it is presumed, that they carried out their responsibilities with proper care. I intend to demonstrate, that the czech business judgment rule is flawed, despite the fact that it draws from foreign examples and that this regulation, although seemingly groundbreaking, in fact changes nothing in examination of the decisions of the company executive officers in Czech Republic. The main goal of this article is therefore to analyze and criticize the business judgment rule in the new Czech legislation and to compare it to notable foreign legal systems. The methods used are inductive and deductive reasoning, author‘s own analysis of legal text, comparative method and compilation of available resources relating to the topic of the article.

  5. Czech Companies Involved in the ARTEMIS Programme

    Czech Academy of Sciences Publication Activity Database

    Kadlec, Jiří

    -, special issue (2013), s. 4-5 ISSN 1210-9592 R&D Projects: GA MŠk(CZ) LE13020 Keywords : ARTEMIS JU * embedded systems * european technology platforms * FP7 * ICT * microelectronics * ENIAC JU Subject RIV: AF - Documentation, Librarianship, Information Studies http://library.utia.cas.cz/separaty/2013/ZS/kadlec-czech companies involved in the artemis programme.pdf

  6. The patent activity of the Czech R

    Directory of Open Access Journals (Sweden)

    Kučera Zdeněk

    2016-12-01

    Full Text Available An effective knowledge transfer between research institutions and industry is a significant bottleneck in the national innovation system. CR adopted in recent years a series of systemic measures aimed to stimulate the orientation of the R&D organizations towards the generation of knowledge directly applicable in the innovation process and more generally to improve the collaboration of the R&D establishment with the industry. In the majority of programs supporting the applied research patents and industrial designs and utility models are among the anticipated results. The Methodology of the evaluation of R&D organizations implemented in the second half of the last decade brought financial bonuses for the creation of the results in the category of industrial property. Despite of this stimulus CR lags behind the technologically advanced EU countries in the patent activities. The topic of this article is a comparison of the protection of the industrial property rights in the Czech higher education institutions and governmental R&D institutions with selected EU countries. We make use of a couple of quantitative indicators to assess the quality and the technological and the commercial potential of the produced industrial property. Despite a dynamic growth of the patent applications in the CR the number of patent applications relative to the country size is far below the EU-15 average. The Czech research organizations contribute to a higher extent to the number of patent applications then do the analogous institutions in EU-15 countries where the majority of patent applications come from the industrial sphere. The Czech research organizations mainly limit the patent rights to the Czech Republic whereas in the EU-15 countries the opposite is preponderant and only a small fraction of patent applications remains limited to the national environment. Thus the majority of the Czech patents created by research organizations cannot be commercialized on the

  7. Author Details

    African Journals Online (AJOL)

    Al-Selwi, AHA. Vol 7, No 2 (2012) - Articles Peutz Jeghers Syndrome presented as intermittent gastric outlet obstruction and ileoileal intussusceptions. Abstract. ISSN: 1858-5051. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

  8. LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism

    NARCIS (Netherlands)

    Jansen, Marnix; ten Klooster, Jean Paul; Offerhaus, G. Johan; Clevers, Hans

    2009-01-01

    Jansen M, ten Klooster JP, Offerhaus GJ, Clevers H. LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism. Physiol Rev 89: 777-798, 2009; doi:10.1152/physrev.00026.2008. Research on the LKB1 tumor suppressor protein mutated in cancer-prone Peutz-Jeghers

  9. Genetics of Colorectal Cancer (PDQ®)—Health Professional Version

    Science.gov (United States)

    Hereditary colorectal cancer syndromes include Lynch syndrome and several polyposis syndromes (familial adenomatous polyposis, MUTYH-associated polyposis, juvenile polyposis syndrome, Peutz-Jeghers syndrome, and serrated polyposis syndrome). Learn about the genetics, clinical manifestations, management, and psychosocial aspects of these and other hereditary colon cancer syndromes in this expert-reviewed summary.

  10. The Czech Labour Market and Flexicurity

    Directory of Open Access Journals (Sweden)

    Potužáková Zuzana

    2009-12-01

    Full Text Available Flexicurity reflects the current basic trend within the EU in guaranteeing high employment levels and attainability of national fiscal systems. It was introduced in Denmark in 90ties and helped to reduce the (long-term unemployment levels significantly. The Czech labour market, despite the transformation process, has still a space for further improvement, especially in the time of economic slow-down. The aim of the paper is to describe the flexicurity elements in the Czech Republic. First of all, we describe the general economical background and compare it with other Central European economies and with situation in Denmark where the concept comes from. In other parts of the paper we analyze the particular elements of the so called golden triangle of flexicurity – flexible labour market, generous welfare system and active labour market policies. We also focus on the components of the flexicurity, which the Czech labour market still lacks and would be useful to implement them. Despite the fact that the previous period (years 2005-2008 was very successful, the period was not used effectively to reform the labour market deeper. The Czech labour market faces nowadays several crucial problems such as too high employment protection of the regular workers or small incentives for the long-term unemployed to re-enter the labour market. As a result of these features we can speak without doubt about dual labour market protecting part of labour force too generously and leaving too many people outside the market. Further the construction of the social system does not motivate the long-term unemployed to enter the labour market again or to get further qualification to boost their chances to get a job again. All these facts lead to the ineffective operation with the human capital in the Czech Republic and deepen the costs on social and relating policies.

  11. Occupational skin diseases in Czech healthcare workers from 1997 to 2009.

    Science.gov (United States)

    Machovcová, A; Fenclová, Z; Pelclová, D

    2013-04-01

    The healthcare sector ranked in second place among economic sectors in the Czech Republic, with about 11.4 % of all occupational diseases in 2009. Skin diseases constituted about 20 % of all occupational diseases. The aim of this study was to analyze the causes and trends in allergic and irritant-induced skin diseases in the healthcare sector. The data concerning occupational skin diseases (Chapter IV of the Czech List of Occupational Diseases, non-infectious skin illnesses) in the healthcare sector were analyzed from the Czech National Registry of Occupational Diseases from 1997 until 2009. The trends in the total counts and most frequent causes were evaluated. During the past 13 years, a total of 545 skin diseases were acknowledged in healthcare workers. Allergic contact dermatitis was diagnosed in 464 (85 %), irritant contact dermatitis in 71 (13 %) and contact urticaria in 10 subjects (2 %). Ninety-five percent of the patients were females. The overall incidence in individual years varied between 1.0 and 2.9 cases per 10,000 full-time employees per year. Disinfectants were the most frequent chemical agents causing more than one third of all allergic skin diseases (38 %), followed by rubber components (32 %) and cleaning agents (10 %). A general downward trend of diagnosed cases of occupational skin diseases in heath care workers in the Czech Republic over the past 13 years was demonstrated.

  12. [Pharmacoeconomy of diabetes mellitus--trends in the Czech Republic].

    Science.gov (United States)

    Horák, P

    2009-04-01

    Since 2002, we found relatively stable number of diabetes mellitus cases among clients of General Health Insurance Company of the Czech Republic. This means, after calculating incidence rate with respect to decline in total numbers of insured during the same period, a 6% increase in real incidence rate. On the doctors side, outpatient, mostly private diabetologists have about the same capacity of their offices, 2.9 physicians (WTE)/100 000 citizens over the last years. Analysis of costs and volume of services provided, clearly demonstrate, that diabetology is medical specialization of a great importance not only from the point of view of number of patients and services provided but also of its influence on the overall health care costs. Data show not only higher average expenses for treatment of patients with diabetes mellitus compared to average expenses incurred for treatments of all other diagnoses, but show also a crucial relationship of costs with presence or absence of diabetes mellitus complications. Money spend by the medical insurance system and also and more importantly health profit to patients can thus be substantially influenced via improvements in organization of care, via higher involvement, compliance of patients to the treatment and to necessary change in their lifestyles and last but not least via increase in quality of care. Cost control can be achieved by strengthening the role of pharmacoeconomics in decisions making processes of health insurance companies, importance of which is demonstrated on the past developments on drug market in the Czech Republic. General Health Insurance Company will target these goals in coming years and in its business plans will also include expected increases of costs for organization of care and for higher renumeration of physicians as well.

  13. Music stations in czech TV broadcasting and their presenters

    OpenAIRE

    Klementová, Ema

    2013-01-01

    This thesis compares two significant music televisions in Czech television broadcasting, MTV and TV Óčko. Also it describes the development and history of the first American music television MTV and also it provides a view to some similar features of the development of the American MTV and the development of the Czech music televisions. Both Czech music televisions are also compared in terms of the program structure. The practical part of this thesis is based on interviews with four presenter...

  14. Appraisal of Transparency International in the Czech Republic

    OpenAIRE

    Kubrová, Lucie

    2017-01-01

    This thesis aims to assess the marketing strategy and HR management done at Transparency International in the Czech Republic and to propose improvements that could help increase the awareness about the organization. To achieve this, the perception of the Czech citizens is evaluated via questionnaire. Afterwards the marketing strategy done in the Czech branch is described based on the interview with the representative of Transparency International. In the end, the individual elements are compa...

  15. Czech Bankruptcy Procedures: Ex-post Efficiency View

    OpenAIRE

    Ondøej Knot; Ondøej Vychodil

    2006-01-01

    The paper presents facts on the ex-post efficiency of the Czech bankruptcy procedures. First, it briefly summarizes in what aspects bankruptcy systems differ across countries and introduces the main observations made about the Czech case so far. Second, international data are presented to assess the Czech standings in four aspects of bankruptcies' ex-post efficiency – duration, recovery rate, administrative costs, and continuation/liquidation decision. Third, the paper provides a summary of s...

  16. Recognition of Emotions in Czech Newspaper Headlines

    Directory of Open Access Journals (Sweden)

    R. Burget

    2011-04-01

    Full Text Available With the growth of internet community, many different text-based documents are produced. Emotion detection and classification in text becomes very important in human-machine interaction or in human-to-human internet communication with this growth. This article refers to this issue in Czech texts. Headlines were extracted from Czech newspapers and Fear, Joy, Anger, Disgust, Sadness, and Surprise emotions are detected. In this work, several algorithms for learning were assessed and compared according to their accuracy of emotion detection and classification of news headlines. The best results were achieved using the SVM (Support Vector Machine method with a linear kernel, where the presence of the dominant emotion or emotions was analyzed. For individual emotions the following results were obtained: Anger was detected in 87.3 %, Disgust 95.01%, Fear 81.32 %, Joy 71.6 %, Sadness 75.4 %, and Surprise 71.09 %.

  17. POPULATION STUDIES OF CZECH HUCUL HORSES

    Directory of Open Access Journals (Sweden)

    Hana Vostrá Vydrová

    2015-09-01

    Full Text Available Population studies were carried out analysis Czech Hucul breed based on pedigree information of animals registered in the Studbook. Pedigree records collected from the year 1834 to 2013 comprised information on 9455 animals used in the analyses. The pedigree depth of the analysed individuals was up to 19 generations. The mean value of inbreeding coefficient was 5.35% (with maximum value 30%. The proportion of inbreed animals was high (98%. The average rate of inbreeding in the reference population was lower than 1%, and the respective estimates of effective population sizes were 54. The presented paper is indicating that genetic diversity in the Czech Hucul breeds is still relatively high and conservation programs should be continued.

  18. Customer Loyalty Measurement at Czech Organizations

    Directory of Open Access Journals (Sweden)

    David Vykydal

    2013-07-01

    Full Text Available All organizations certified against the ISO 9001 requirements must also measure customer satisfaction. But customer loyalty represents quality management system maturity on higher level of objectivity. An purpose of the article is bring set of information on current state analysis of customer loyalty measurement at Czech companies. Principal methodology of this analysis was special field survey and our research too. Results of special research performed through focus groups, based on risk analysis in the field of quality management principles implementation, are presented there as a part of findings. The another important findings show that customer loyalty measurement is mostly underestimated or ignored at Czech organizations. Main reasons of such state are also described. As well as: the first proposal of original methodology how to measure three fundamental types of customer loyalty - advocasy, purchasing and retention loyalty is also included to this article.

  19. Punning Wordplay in Czech Advertising Discourse

    Directory of Open Access Journals (Sweden)

    Věra Sládková

    2017-05-01

    Full Text Available This account of punning wordplay in Czech advertising discourse draws on the recent popularity of pun and the research, for which the theory of lexical priming provides lexico-grammatical framework. The corpus-based evidence of combinatorial behaviour of linguistic features, and the processes behind reinterpretations and sense selections aid an analysis of the reasons why many pun attempts failed to achieve the desired effect, and at the same time explain which features are successful in generating amusement in Czech puns. The processes of relexicalisation and reworking were observed in a considerable number of instances in older and more recent advertising puns, the sources of ambiguity identified, and puns were compared, contrasted and classified. At the same time a shift from reliance on one ambiguous feature to employing multiple psycholinguistic phenomena and their combinations has been identified.

  20. Transparency of Shareholders in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Jindřiška Šedová

    2014-01-01

    Full Text Available The recodification of commercial and civil law in the Czech Republic has resulted in a new concept for the legislation relating to securities. Significant changes have also been made to the legislation covering shares. The new legislation concerns not only the actual form of shares, but also their circulation. The aim of this article is to highlight the most important changes in the legislation relating to bearer shares, especially bearer shares in paper form, and to assess these changes from the viewpoint of their impact on the transparency of joint stock companies and uncontrolled circulation of shares. This assessment will be based on an appraisal of the importance of bearer shares for capital business in the Czech Republic and the effects the new legislation is expected to bring about. The article will also consider possible alternatives in the behavior of shareholders (investors who prefer to remain anonymous.

  1. BRAIN DRAIN – BRAIN GAIN: SLOVAK STUDENTS AT CZECH UNIVERSITIES

    Directory of Open Access Journals (Sweden)

    FISCHER, Jakub

    2015-09-01

    Full Text Available The Slovak Republic is experiencing a growing brain drain of elite secondary school students. Slovak human capital flows chiefly to Czech Higher Education Institutes (HEIs. The aim of this paper is to analyse who these Slovak students are to create a complete profile of Slovak students at Czech HEIs. We used a unique dataset based on the surveys EUROSTUDENT V and DOKTORANDI 2014 to explore differences between Czech and Slovak students, their financial situation and the functionality of the intergenerational transmission mechanism. We have found that Slovak students at Czech HEIs come from highly educated families and from the middle and higher class families significantly more often than Czech students at Czech HEIs or Slovak students at Slovak HEIs. Approximately 80% of them came from grammar schools. Slovak students also often have better language skills. We have discovered that Slovak students at Czech HEIs enjoy certain social benefits, slightly more often they have higher monthly income compared to Czech students, and they work slightly less often during their studies. Finally, according to our findings, Slovak doctoral students are often reluctant to return back to the Slovak Republic or to stay in the Czech Republic.

  2. Approach of Czech regulatory body to LBB

    Energy Technology Data Exchange (ETDEWEB)

    Tendera, P.

    1997-04-01

    At present there are two NPPs equipped with PWR units in Czech Republic. The Dukovany, NPP is about ten years in operation (four units 440 MW - WWBFL model 213) and Tomelin NPP is under construction (two units 1000 MW - WWER model 320). Both NPPs were built to Soviet design and according to Soviet regulations and standards but most of equipment for primary circuits was supplied by home manufacturers. The objective of the Czech LBB program is to prove the LBB status of the primary piping systems of there NPPs and the LBB concept is a part of strategy to meet western style safety standards. The reason for the Czech LBB project is a lack of some standard safety Facilities too. For both Dukovany and Tomelin NPPs a full LBB analysis should be carried out. The application of LBB to the piping system should be also a cost effective means to avoid installations of pipe whip restraints and jet shields. The Czech regulatory body issued non-mandatory requirement, {open_quotes}Leak Before Break{close_quotes} which is in compliance with national legal documents and which is based on the US NRC Regulatory Procedures and US standards (ASMF CODE, ANSI). The requirement has been published in the document {open_quotes}Safety of Nuclear Facilities{close_quotes} No 1/1991 as {open_quotes}Requirements on the Content and Format of Safety Reports and their Supplements{close_quote} and consist of two parts (1) procedure for obtaining proof of evidence {open_quotes}Leak Before Break{close_quotes} (2) leak detection systems for the pressurized reactor primary circuit. At present some changes concerning both parts of the above document will be introduced. The reasons for this modifications will be presented.

  3. Occupational gender segregation in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Jurajda, Š.; Franta, Michal

    2007-01-01

    Roč. 57, 5-6 (2007), s. 255-271 ISSN 0015-1920 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : occupational segegration * women * Czech Republic Subject RIV: AH - Economics Impact factor: 0.382, year: 2007 http:// journal .fsv.cuni.cz/storage/1077_fau_5_6_2007_00000000057.pdf

  4. Occupational gender segregation in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Jurajda, Štěpán; Franta, M.

    2007-01-01

    Roč. 57, 5-6 (2007), s. 255-271 ISSN 0015-1920 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:MSM0021620846 Keywords : occupational segegration * women * Czech Republic Subject RIV: AH - Economics Impact factor: 0.382, year: 2007 http:// journal .fsv.cuni.cz/storage/1077_fau_5_6_2007_00000000057.pdf

  5. CAR2 - Czech Database of Car Speech

    Directory of Open Access Journals (Sweden)

    P. Sovka

    1999-12-01

    Full Text Available This paper presents new Czech language two-channel (stereo speech database recorded in car environment. The created database was designed for experiments with speech enhancement for communication purposes and for the study and the design of a robust speech recognition systems. Tools for automated phoneme labelling based on Baum-Welch re-estimation were realised. The noise analysis of the car background environment was done.

  6. CAR2 - Czech Database of Car Speech

    OpenAIRE

    Pollak, P.; Vopicka, J.; Hanzl, V.; Sovka, Pavel

    1999-01-01

    This paper presents new Czech language two-channel (stereo) speech database recorded in car environment. The created database was designed for experiments with speech enhancement for communication purposes and for the study and the design of a robust speech recognition systems. Tools for automated phoneme labelling based on Baum-Welch re-estimation were realised. The noise analysis of the car background environment was done.

  7. Relationship between Czech windstorms and air temperature

    Czech Academy of Sciences Publication Activity Database

    Kašpar, Marek; Müller, Miloslav; Crhová, L.; Holtanová, E.; Polášek, J. F.; Pop, Lukáš; Valeriánová, A.

    2016-01-01

    Roč. 37, č. 1 (2016), s. 11-24 ISSN 0899-8418 R&D Projects: GA ČR(CZ) GAP209/11/1990 Institutional support: RVO:68378289 Keywords : windstorm * strong wind * weather extreme * temperature anomaly * temperature gradient * seasonality * Czech Republic Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 3.760, year: 2016 http://onlinelibrary.wiley.com/doi/10.1002/joc.4682/abstract

  8. Approach for Czech regulatory body to LBB

    Energy Technology Data Exchange (ETDEWEB)

    Tendera, P. [State Office for Nuclear Safety (SONS), Prague (Czech Republic)

    1997-04-01

    At present there are two NPPs equipped with PWR units in Czech Republic. The Dukovany NPP is about ten years in operation (four units 440 MW - WWER model 213) and Temelin NPP is under construction (two units 1000 MW-WWER model 320). Both NPPs were built to Soviet design and according to Soviet regulations and standards but most of equipment for primary circuits was supplied by home manufactures. The objective for the Czech LBB programme is to prove the LBB status of the primary piping systems of these NPPs and the LBB concept is a part of strategy to meet western style safety standards. The reason for the Czech LBB project is a lack of some standard safety facilities, too. For both Dukovany and Temolin NPPs a full LBB analysis should be carried out. The application of LBB to the piping system should be also a cost effective means to avoid installations of pipe whip restraints and jet shields. The Czech regulatory body issued non-mandatory requirement {open_quotes}Leak Before Break{close_quotes} which is in compliance with national legal documents and which is based on the US NRC Regulatory Procedures and US standards (ASME, CODE, ANSI). The requirement has been published in the document {open_quotes}Safety of Nuclear Facilities{close_quotes} No. 1/1991 as {open_quotes}Requirements on the Content and Format of Safety Reports and their Supplements{close_quotes} and consists of two parts (1) procedure for obtaining proof of evidence {open_quotes}Leak Before Break{close_quotes} (2) leak detection systems for the pressurized reactor primary circuit. At present some changes concerning both parts of the above document will be introduced. The reasons for this modifications will be presented.

  9. Performance factors of Czech brewing industry companies

    Directory of Open Access Journals (Sweden)

    Gabriela Chmelíková

    2013-01-01

    Full Text Available The aim of this paper is to identify and subsequently quantify the intensity of relation between selected value drivers of Czech brewing industry companies and thus answer the question of what the significance level of partial indicators influencing the economic value added in the Czech brewing industry is. The aim was achieved by construction and application of multifactorial model for value generators explanation, which represents a synthesis of the INFA model and performance system Balanced Scorecard. The features typical for the first part of the model are algorithmized relations and financial character of the elements, while in the second with non-financial elements the ability of algorithmization is lost and the connection are defined solely on the basis of causality. This inconsistency also implied the difference in the character of analysis results. The proposed model made it possible to identify the most significant generators of value in the Czech brewing industry and it thus became an important guideline for brewery management. The results of the analysis offer a comprehensive overview of the most important value generators and thus enable the company managers to attain the goals of the owners more effectively.

  10. Health tourism in a Czech health spa.

    Science.gov (United States)

    Speier, Amy R

    2011-04-01

    This paper is about the changing shape of health tourism in a Czech spa town. The research focuses on balneotherapy as a traditional Czech healing technique, which involves complex drinking and bathing therapies, as it is increasingly being incorporated into the development of a Czech health tourism industry. Today, the health tourism industry in Mariánske Lázne is attempting to 'harmoniously' combine three elements--balneology, travel and business activities. One detects subtle shifts and consequent incongruities as doctors struggle for control over the medical portion of spa hotels. At the same time, marketing groups are creating new packages for a general clientele, and the implementation of these new packages de-medicalizes balneotherapy. Related to the issue of the doctor's authority in the spa, the changes occurring with the privatization of tourism entails the entrance of 'tourists' to Mariánske Lázne who are not necessarily seeking spa treatment but who are still staying at spa hotels. There is a general consensus among spa doctors and employees that balneotherapy has become commodified. Thus, while balneotherapy remains a traditional form of therapy, the commercial context in which it exists has created a new form of health tourism.

  11. Energy policy of the Czech Republic

    Energy Technology Data Exchange (ETDEWEB)

    Cerny, M. [Ministry of Industry and Trade, Prague (Czechoslovakia)

    1995-12-01

    On February 16, 1992, the Government of the Czech Republic sanctioned, by its Decree No. 112/82, its first Energy Policy. Since that time, a number of conditions have changed: first of all, there was the partition of the former Federal Czechoslovak Republic, then the privatization of most of energy producing corporations, the deregulation of a significant proportion of power and energy commodities, the decision to bring to an end the construction of the Temelin nuclear power station, the creation of conditions for the construction of the Ingoldstadt oil pipeline, etc. These steps, on which the final decisions have been made, have brought about the necessity of updating the existing general Energy Policy. The updated Energy Policy is based on the Programme Statement by the Government of the Czech Republic of July 1992, as well as on other materials associated with energy and power generation, either approved or negotiated by the Government, in particular the State Environmental Policy the Rules of the State Raw Materials Policy, the European Association Agreement, the European Energy Charter, the results of the Uruguayan Round of GATT, the Convention on Climate Changes, the Ecological Action Programme for central and East-European countries, and other international documents that have either been, or are likely to be sanctioned by the Czech Government (especially the European Energy Charter Treaty, and the protocol on Trans-boundary Air Pollution and on Further Reduction of Sulphur Oxide Emissions).

  12. The present state of brachytherapy practice in the Czech Republic

    International Nuclear Information System (INIS)

    Zackova, H.; Drabkova, A.

    1995-01-01

    In spite of the fact that radiotherapy departments in the Czech republic have been following the general European and world trends in brachytherapy techniques and that they are installing the new remote AFL systems, the reserves of radium sources are still considerably high and not all professionals carry out their applications of radioactive sources by (at least) manual AFL. In near future the attention should be paid to the diminution of the unnecessary radium reserves at that radiotherapy departments where the small number of applications is executed or where the new remote AFL systems are used. For professionals practically thorough radiation protection is assured when new remote AFL systems are used. But in this case an attention should be paid to the radiation safety of the patient because of the potential exposures when high dose rate systems would failed. The likelihood of this unwanted cases can only be decreased when Quality Assurance programs is introduced into practice

  13. The Uraniummining and Storage of Nuclear Waste in Czech Republic

    Science.gov (United States)

    Čechák, Tomáš; Klusoň, Jaroslav

    The paper describes the situation in the uranium mining and spent fuel management in the Czech Republic. Uranium mining has a long history in the Jachymov area. By the 1960s Czech mines producing 3000 tons a year. After 1989 the uranium mine are mostly closed down and only one active mine in Rozna is active and it is being phased out.

  14. Tertiary Education in the Czech Republic: The Pathway to Change

    Science.gov (United States)

    Pesik, Richard; Gounko, Tatiana

    2011-01-01

    This article analyzes recent policy proposals to reform Czech tertiary education. A brief overview of the evolution of Czech tertiary education presents the background against which emerging policy trends in education are examined. We relate the changes in tertiary education to the policy framework and recommendations of the OECD, underpinned by…

  15. [Prolegomenon of the Czech pharmacognosy: 21st century].

    Science.gov (United States)

    Opletal, Lubomír

    2013-04-01

    The paper analyzes the basic features of the development of pharmacognosy as the oldest profile subject of pharmacy primarily in Europe during the 20th century. Historical consequences of its development are declared, which should create the basis for its embedment, new content and tasks in Czech pharmacy of the 21st century, especially in education at Czech universities.

  16. GHG emission mitigation measures and technologies in the Czech Republic

    Energy Technology Data Exchange (ETDEWEB)

    Tichy, M. [Energy Efficiency Center, Prague (Czech Republic)

    1996-12-31

    The paper presents a short overview of main results in two fields: projection of GHG emission from energy sector in the Czech Republic and assessment of technologies and options for GHG mitigation. The last part presents an overview of measures that were prepared for potential inclusion to the Czech Climate Change Action Plan.

  17. Czech Participation in the INTEGRAL Satellite: A Review

    Directory of Open Access Journals (Sweden)

    R. Hudec

    2011-01-01

    Full Text Available The ESA INTEGRAL satellite, launched in October 2002, is the first astrophysical satellite of the European Space Agency ESA with Czech participation. The results of the first 7 years of investigations of various scientific targets e.g. cataclysmic variables, blazars, X-ray sources, and GRBs with the ESA INTEGRAL satellite with Czech participation are briefly presented and discussed.

  18. Body Parameters of Czech Breastfed Children Compared to the Czech References and WHO Growth Standards

    Czech Academy of Sciences Publication Activity Database

    Riedlová, J.; Vignerová, J.; Paulová, M.; Musil, V.; Brabec, Marek; Schneidrová, D.

    2017-01-01

    Roč. 44, č. 7 (2017), s. 593-599 ISSN 0301-4460 Grant - others:GA MZd(CZ) NS9974 Institutional support: RVO:67985807 Keywords : breastfed children * Czech reference * Growth charts * WHO growth standards Subject RIV: BB - Applied Statistics, Operational Research OBOR OECD: Statistics and probability Impact factor: 1.240, year: 2016

  19. Undeclared Work in the Czech Republic and its Implications for the Czech Labor Market

    Directory of Open Access Journals (Sweden)

    Strielkowski

    2013-12-01

    Full Text Available This paper aims at describing the issue of undeclared work in the Czech Republic and to explain the burdens it represents for the national economy. It also describes what measures can be undertaken in order to tackle undeclared work and uses some real-life examples to illustrate their outcomes. Undeclared work and the so-called “švarc systém” (the employer-employee relations with a person exercising the employer's normal activities not being an employee in legal terms but acting as an independent entrepreneur are among the biggest issues on the Czech labor market nowadays. According to some estimations, the Czech state loses about five billion CZK annually in the form of uncollected taxes, unpaid revenues and health and social insurance payments. New changes to the Czech labor legislation that came into force in 2012 were envisaged to tackle undeclared work, reduce tax evasions, fight shadow practices on the labor market, and to prevent social deprivation and other threats for the society by shifting the competences to conduct random checks, and controls of firms and businesses were transferred to the State Labor Inspection Offices (SLIO. The changes in the legislation facilitated the identification of the undeclared work and penalizing of its bearers, which minimized the losses from the illegal employment.

  20. Molluscan succession from Holocene tufas in the Czech Karst (Czech Republic)

    Czech Academy of Sciences Publication Activity Database

    Hlaváč, Jaroslav

    2006-01-01

    Roč. 57, č. 5 (2006), s. 405-414 ISSN 1335-0552 R&D Projects: GA AV ČR IAA300130505 Institutional research plan: CEZ:AV0Z30130516 Keywords : Holocene * Czech Republic * radiocarbon age * calcareous tufas * malacofauna Subject RIV: EG - Zoology Impact factor: 0.364, year: 2006 http://www.geologicacarpathica.sk/src/main.php

  1. Liquidity Risk Sensitivity of Czech Commercial Banks

    Directory of Open Access Journals (Sweden)

    Pavla Vodová

    2014-01-01

    Full Text Available The recent financial crisis has shown that a liquidity risk plays an important role in the current developed financial system. One of the efficient tools of liquidity risk management is stress testing which can show banks their potential vulnerability to liquidity shocks. The aim of this paper is therefore to measure the liquidity risk sensitivity of Czech commercial banks and to find out the most severe scenario and the most vulnerable bank. Our sample included significant part of the Czech banking sector; we used unconsolidated balance sheet data over the period from 2000 to 2011 which were obtained from annual reports of Czech banks. We have evaluated liquidity risk of each bank in the sample via six different liquidity ratios. Then we stressed these baseline values in three stress scenarios: run on a bank (simulated by a 20% withdrawal of deposits, confidence crisis on the interbank market (simulated by a withdrawal of 20% of interbank deposits and use of committed loans by counterparties (simulated by a 5% increase of loans provided to nonbank clients. We measured the impact of all scenarios by relative change of liquidity ratios. The impact of modelled liquidity shocks differs among scenarios. The most serious liquidity problems would be caused by the first scenario – run on a bank. The negative influence of third scenario (use of committed loans is less severe. The confidence crisis on the interbank market would not affect bank liquidity at all. The results also show that the severity of the impact of all scenarios worsens in periods of financial distress. We have also found that large and medium sized banks are most vulnerable to liquidity shocks, mainly to massive deposit withdrawals.

  2. Czech studies of lung cancer and radon

    International Nuclear Information System (INIS)

    Tomasek, L.

    2002-01-01

    According to the International Agency for Research on Cancer, there is a significant evidence to classify radon as a carcinogen. Using extrapolations from occupational studies, it can be shown that for some countries environmental exposure to radon is the second most important cause of lung cancer in the general population after cigarette smoking. Czech studies among uranium miners, established in 1970 by Josef Sevc, and in the general population aim to contribute to knowledge on the risk from radon, particularly by evaluating temporal factors and interaction of radon exposure and smoking

  3. Drug Policy in the Czech Republic.

    Science.gov (United States)

    Skoupá, Jana

    2017-09-01

    The legal background of the current pharmaceutical pricing and reimbursement (P&R) setting in the Czech Republic is based on Act 48/1997. Since 2008, the P&R process has been coordinated by the State Institute for Drug Control, which is the main stakeholder in the decision-making process; marketing authorization holders and insurance funds (IFs) also participate. To present a general overview of the current Czech health care system and its P&R principles. The study used publicly available sources concerning health care, mainly acts related to public health care and public health care insurance, public notices related to P&R setting, and statistical data. Regulation covers P&R. The official price represents the highest exfactory price, which cannot be exceeded. It is calculated as the mean of the three lowest prices in the European Union reference basket. Reimbursement is based on the lowest price per daily dose across the whole European Union. For reimbursement, products can be clustered into jumbo groups (mutually interchangeable), stated by law. In each group, reimbursement is set at the lowest price of any substance within the group. For highly innovative drugs a temporary reimbursement can be granted for a period of 3 years. During the administrative proceeding, efficacy, safety, cost-effectiveness, and budget impact are assessed. The cost-effectiveness principles are aligned with the guidelines of the National Institute for Health and Clinical Care Excellence, preferring cost-utility analyses. The willingness-to-pay threshold has been implicitly set at 3 times the gross domestic product per capita. Products exceeding this threshold are subject to further risk-sharing negotiations. Budget impact is becoming increasingly important mainly for IFs. The IFs have recently introduced their own methodology, which allows only products with a budget impact in the range of CZK16 to CZK48 million (CZK = Czech koruna; ∼€600,000 to €1.8 million) to enter the system

  4. The FTO variant is associated with chronic complications of diabetes mellitus in Czech population.

    Science.gov (United States)

    Hubacek, Jaroslav A; Dlouha, Dana; Klementova, Marta; Lanska, Vera; Neskudla, Tomas; Pelikanova, Terezie

    2018-02-05

    Genome-wide association studies have resulted in the identification of the FTO gene as an important genetic determinant of diabetes mellitus. The aim of this study was to confirm the role of this gene in the development of DM in the Czech-Slavonic population and to analyse whether this gene is associated with common DM complications. Two groups of patients (814 with T1DM and 848 with T2DM) and a group of healthy controls (2339 individuals) - both of Czech origin - were genotyped for the FTO rs17817449 SNP. ANOVA and logistic regression were used for the statistical evaluations. The frequency of the GG genotype was significantly higher in T2DM (25.4% vs. 16.7%, Pdiabetic nephropathy was observed both for T1DM patients (GG vs. TT homozygotes, Pdiabetic neuropathy (GG vs. TT comparison; Pretinopathy was detected. All presented values are after adjustment for age, sex, BMI and duration of diabetes. We confirm the association between the FTO rs17817449 SNP and susceptibility to T2DM in the Czech-Slavonic population. The same variant is associated with a spectrum of chronic complications in both types of diabetes. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features.

    Science.gov (United States)

    Zakharov, Sergey; Pelclova, Daniela; Urban, Pavel; Navratil, Tomas; Diblik, Pavel; Kuthan, Pavel; Hubacek, Jaroslav A; Miovsky, Michal; Klempir, Jiri; Vaneckova, Manuela; Seidl, Zdenek; Pilin, Alexander; Fenclova, Zdenka; Petrik, Vit; Kotikova, Katerina; Nurieva, Olga; Ridzon, Petr; Rulisek, Jan; Komarc, Martin; Hovda, Knut Erik

    2014-12-01

    Methanol poisonings occur frequently globally, but reports of larger outbreaks where complete clinical and laboratory data are reported remain scarce. The objective of the present study was to report the data from the mass methanol poisoning in the Czech Republic in 2012 addressing the general epidemiology, treatment, and outcomes, and to present a protocol for the use of fomepizole ensuring that the antidote was provided to the most severely poisoned patients in the critical phase. A combined prospective and retrospective case series study of 121 patients with confirmed methanol poisoning. From a total of 121 intoxicated subjects, 20 died outside the hospital and 101 were hospitalized. Among them, 60 survived without, and 20 with visual/CNS sequelae, whereas 21 patients died. The total and hospital mortality rates were 34% and 21%, respectively. Multivariate regression analysis found pH 0.05). Severity of metabolic acidosis, state of consciousness, and serum ethanol on admission were the only significant parameters associated with mortality. The type of dialysis or antidote did not appear to affect mortality. Recommendations that were issued for hospital triage of fomepizole administration allowed conservation of valuable antidote in this massive poisoning outbreak for those patients most in need.

  6. Regorafenib in the Real-Life Clinical Practice: Data from the Czech Registry.

    Science.gov (United States)

    Kopeckova, Katerina; Buchler, Tomas; Bortlicek, Zbynek; Hejduk, Karel; Chloupkova, Renata; Melichar, Bohuslav; Pokorna, Petra; Tomasek, Jiri; Linke, Zdenek; Petruzelka, Lubos; Kiss, Igor; Prausova, Jana

    2017-02-01

    To describe the use of regorafenib for the treatment of metastatic colorectal cancer (mCRC) in clinical practice in the Czech Republic, and to describe the clinical outcomes of patients in terms of safety and survival. The data of patients treated with regorafenib were extracted from the national CORECT registry. The CORECT registry is a non-interventional post-marketing database, gathering information about patients with CRC and treated with targeted agents. Twenty oncology centres in the Czech Republic contributed to this registry. Collected data included patients' characteristics, disease history, cancer treatments, response to treatments and safety. A total of 148 patients treated with regorafenib in clinical practice were analysed. At regorafenib initiation, almost all patients were fully active or slightly restricted in physical activity. Regorafenib was not administered as first-line treatment in any patient. Median progression-free survival was 3.5 months and median overall survival was 9.3 months. One-year survival rate was 44.6 %. Four partial responses were observed and 51 stable diseases. Progression was observed in 66 patients (44.6 %). The main reported adverse events were skin toxicity (5.4 %) and fatigue (2.0 %). Regorafenib is a well-established treatment for pretreated patients with mCRC, however real-life data are scarce. Our results demonstrated slightly better efficacy of regorafenib and better safety profile in patients with mCRC compared to the randomised trials.

  7. Visitors Satisfaction Measurement in Czech Tourism

    Directory of Open Access Journals (Sweden)

    Tomáš Sadílek

    2015-01-01

    Full Text Available The paper deals with describing the method of satisfaction measurement as a one of marketing techniques used for detecting visitors’ satisfaction in tourist regions in the Czech Republic. In the treatise, we try to analyse visitors’ satisfaction with the twenty four partial factors affecting total satisfaction. In the theoretical part of the paper, there are described methodological approaches to satisfaction measurement and presented various methods for satisfaction measurement with focus on the Satisfaction Pyramid method which is also used in the field part. Other presented methods are Customer Satisfaction Index, European Customer Satisfaction Model, Importance-Satisfaction Matrix, SERVQUAL Concept and KANO Model. Data have been collected all over the Czech Republic in years 2010 and 2011 twice every year. In the field part there are presented calculations of data and described total satisfaction, Satisfaction Index and partial satisfactions as well as level of satisfaction by tourist regions and correlations between partial satisfactions and total satisfaction which refers to importance of partial factors. Most important factors affecting total satisfaction are public transport, sport equipment, shopping possibilities, children attractions, orientation signage and free time programs.

  8. Czech Singles in the Market of Services

    Directory of Open Access Journals (Sweden)

    Martin Klepek

    2016-01-01

    Full Text Available The paper deals with specific characteristics of “Czech singles” with emphasis on services area. First, paper determinates the theoretical concept of services marketing in the first chapter. The major part of paper is devoted to primary marketing research. For purpose of collecting data, the method of questioning (combination of off‑line and on‑line approach was chosen. The questionnaire was given to 390 respondents living in the Czech Republic. The data were analysed by SPSS software. Results showed dissimilarities in leisure time activities based on different level of education and income as well as within the gender and age category and city, where particular single person live. Females spend more leisure time on cultural events, home activities as well as shopping and caring for appearance. They also engage with friends as a form of leisure time activity more than males. Educated singles travel more and attend more cultural events and at the same time, they educate themselves more often and do sports much regularly. We also found no relationship between income and shopping as a leisure time activity. This paper describes only a partial output of the primary marketing research with focus on the leisure time spending for the defined segment.

  9. Consumer behaviour on the Czech wine market

    Directory of Open Access Journals (Sweden)

    Helena Chládková

    2004-01-01

    Full Text Available The paper includes partial results of research oriented on conventions and behaviour of consumers on the wine market in the Czech Republic. Based on direct questioning of 1000 respondents from the whole Czech Republic we found, that 11.3% of respondents drink wine several times a week, 29.8% of respondents at least once a week, and 23.2% drink wine several times a month. Only 2.7% of respondents do not drink wine at all. 30.3% of respondents drink wine more often than before, especially because of the fact, that they like wine more, it is of a better quality, and the offer is greater.15.8% of respondents drink wine less often than before of these reasons: health reasons, wine is too expensive, they drive more often.In the groups of respondents with lower amount of wine drunk in usual consummation, there prevail women. Of the total number of women, who answered this question, 75.8% drink less than 0.5 litres in common consummation. In the group of respondents drinking more than 1 litre of wine, there are 5% women and 95% men.

  10. Radiation monitoring network of the Czech Republic

    International Nuclear Information System (INIS)

    Kuca, P.; Novak, L.; Rulik, P.; Tecl, J.

    2003-01-01

    The Radiation Monitoring Network (RMN) of the Czech Republic was established after the Chernobyl accident in 1986 and it is developed all the time. It is co-ordinated by the State Office for Nuclear Safety in co-operation with the National Radiation Protection Institute. Czech RMN consists of the several sub-networks, which include selected or all permanent parts of RMN. The sub-networks are following: the Early Warning Network (EWN), the TLD Territorial Network, the Network of the Measuring Sites of Air Contamination, the Network of Laboratories Equipped with Gamma-spectrometric and Radiochemical Analytical Instrumentation, the Ground and Airborne Mobile Groups. The Laboratory of Monitoring of Internal Contamination and the information system (IS) are a significant part of RMN, too. The data of RMN resulting from monitoring are transferred to the central database of CRMN, processed by the information system (IS). They are used in normal and emergency situations for an evaluation of radiation situation and for preparation of recommendations for protection of the public and the environment. In 2002 any extraordinary radioactivity in the environment was not detected and also none of the measuring points recorded any exceeding of established investigation levels. In components of environment and also in human beings a very low activity of 137 Cs was still measurable, that had been released into environment after the Chernobyl accident and by the nuclear weapon tests in sixties of the last century. (authors)

  11. Basis of economic analysis of Czech firms

    Directory of Open Access Journals (Sweden)

    Gabriela Chmelíková

    2010-01-01

    Full Text Available When looking for connections between particular business’s activities, theory of financial management uses pyramidal system of indicators. The effectiveness of this tool is based on the appropriate choice of the top indicator. Its decomposition enables to manage firm’s processes from the bottommost organizational levels to the main firm’s mission with respect to the connections between par­ti­cu­lar processes. The aim of this paper was to identify appropriate indicator, which corresponds with creation of firm’s value and design its decomposition. To measure creation of firm’s value it is nowadays very popular to use indicator Economic Value Added (EVA. Though from the theoretical point of view EVA is seen as a superior performance metric, the results of some empirical studies do not support this claim. That is why the information content of EVA was controlled in the concrete conditions of Czech Economy within this article. The results showed eligibility of using EVA in Czech firms and enabled to choose it as the top indicator in the pyramidal system. Ambition of further research is to design a complex of indicators offering a comprehensive economic view on the firm’s per­for­man­ce.

  12. SWOT analysis of the Czech Radon programme

    International Nuclear Information System (INIS)

    Fojtikova, I.

    2014-01-01

    Since the early 1990's, the Czech Republic has been one of the countries that carry out a radon programme on its territory, with the aim of protecting people from unnecessary long-term exposure in their homes. Since that time, many achievements have been registered, and many unexpected difficulties have cropped up. This may be the right moment to take some time out to analyse the state of the programme and to determine the direction for its future development. An extended SWOT analysis can serve as a useful tool for this purpose. Originally, SWOT analyses were used exclusively by for-profit organisations aiming to evaluate their perspectives, develop strategies and make plans in order to achieve their objectives. More recently, it has been used in a wide range of decision-making situations when a desired end-state is to be defined. Here, an extended SWOT analysis is used to formulate possible beneficial strategies for advancing anti-radon policy in the Czech Republic. (authors)

  13. SWOT analysis of the Czech Radon programme.

    Science.gov (United States)

    Fojtíková, I

    2014-07-01

    Since the early 1990s, the Czech Republic has been one of the countries that carry out a radon programme on its territory, with the aim of protecting people from unnecessary long-term exposure in their homes. Since that time, many achievements have been registered, and many unexpected difficulties have cropped up. This may be the right moment to take some time out to analyse the state of the programme and to determine the direction for its future development. An extended SWOT analysis can serve as a useful tool for this purpose. Originally, SWOT analyses were used exclusively by for-profit organisations aiming to evaluate their perspectives, develop strategies and make plans in order to achieve their objectives. More recently, it has been used in a wide range of decision-making situations when a desired end-state is to be defined. Here, an extended SWOT analysis is used to formulate possible beneficial strategies for advancing anti-radon policy in the Czech Republic. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Process Segmentation Typology in Czech Companies

    Directory of Open Access Journals (Sweden)

    Tucek David

    2016-03-01

    Full Text Available This article describes process segmentation typology during business process management implementation in Czech companies. Process typology is important for a manager’s overview of process orientation as well as for a manager’s general understanding of business process management. This article provides insight into a process-oriented organizational structure. The first part analyzes process segmentation typology itself as well as some original results of quantitative research evaluating process segmentation typology in the specific context of Czech company strategies. Widespread data collection was carried out in 2006 and 2013. The analysis of this data showed that managers have more options regarding process segmentation and its selection. In terms of practicality and ease of use, the most frequently used method of process segmentation (managerial, main, and supportive stems directly from the requirements of ISO 9001. Because of ISO 9001:2015, managers must now apply risk planning in relation to the selection of processes that are subjected to process management activities. It is for this fundamental reason that this article focuses on process segmentation typology.

  15. The business environment in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Helena Chládková

    2011-01-01

    Full Text Available The paper deals with a comparison of the business environment in 2004 and 2010. The aim of this paper is to compare opinions of managers of small and medium – sized enterprises on opportunities and threats of external environment and on strengths and weaknesses of internal environment after the integration of the Czech Republic into the European Union, in 2004 and now in 2010.The basic sources of information were 70 SWOT analyses of small and medium – sized enterprises which have been made in 2004 by students of combined form of study, who work in management functions on medium or basic managerial levels and 228 SWOT analyses of small and medium – sized enterprises which have been made in 2010. 77 % of managers from analyzed enterprises identified the integration of the Czech Republic into the EU as an opportunity in 2004 and only 33 % of managers from analyzed enterprises in 2010. The competition as the most important threat was reported in both groups of respondents. Namely 64 % of managers in 2004 and even 82 % of managers in 2010.The paper is a part of solution of the research plan of the FBE MUAF in Brno, MSM 6215648904.

  16. Full value documentation in the Czech Food Composition Database.

    Science.gov (United States)

    Machackova, M; Holasova, M; Maskova, E

    2010-11-01

    The aim of this project was to launch a new Food Composition Database (FCDB) Programme in the Czech Republic; to implement a methodology for food description and value documentation according to the standards designed by the European Food Information Resource (EuroFIR) Network of Excellence; and to start the compilation of a pilot FCDB. Foods for the initial data set were selected from the list of foods included in the Czech Food Consumption Basket. Selection of 24 priority components was based on the range of components used in former Czech tables. The priority list was extended with components for which original Czech analytical data or calculated data were available. Values that were input into the compiled database were documented according to the EuroFIR standards within the entities FOOD, COMPONENT, VALUE and REFERENCE using Excel sheets. Foods were described using the LanguaL Thesaurus. A template for documentation of data according to the EuroFIR standards was designed. The initial data set comprised documented data for 162 foods. Values were based on original Czech analytical data (available for traditional and fast foods, milk and milk products, wheat flour types), data derived from literature (for example, fruits, vegetables, nuts, legumes, eggs) and calculated data. The Czech FCDB programme has been successfully relaunched. Inclusion of the Czech data set into the EuroFIR eSearch facility confirmed compliance of the database format with the EuroFIR standards. Excel spreadsheets are applicable for full value documentation in the FCDB.

  17. [Dengue fever cases in Czech workers returning from the Maldives].

    Science.gov (United States)

    Trojánek, Milan; Tomíčková, Dora; Roháčová, Hana; Kosina, Pavel; Gebouský, Jan; Dvořák, Jan; Chmelik, Vaclav; Batistová, Květoslava; Husa, Petr; Maixner, Jan; Sojková, Naděžda; Zelená, Hana; Marešová, Vilma; Stejskal, František

    2013-09-01

    The objective of this study is to present epidemiological characteristics and clinical symptoms of dengue fever cases in Czech workers who acquired the infection while working on the island of Fushivelavaru, Maldives. Furthermore, the study compares the sensitivity of novel direct detection assays, i.e. Real-Time Polymerase Chain Reaction (RT-PCR) and detection of Dengue NS1 antigen. The retrospective study evaluated the clinical course of dengue fever cases in Czech workers returning from a job in the Maldives who were diagnosed with dengue virus infection from September 1 to October 31, 2012. The laboratory diagnosis of dengue fever was based on the serological detection of IgM and IgG antibodies, detection of dengue NS1 antigen by enzyme-linked immunosobent assay (ELISA), and detection of dengue virus DNA by RT-PCR. The infection with dengue virus was confirmed in 18 males with a median age of 40 years (IQR 36-47) who returned from a job in the Maldives. Only one patient required admission to the hospital while the others were treated on an outpatient basis. The most frequently observed symptoms were fever (18), headache (9), muscle and joint pain (8 and 7, respectively), and rash (9). Typical laboratory findings were leukocytopenia and thrombocytopenia, a low CRP level, and elevated aminotransferase activity. The clinical course was uncomplicated in all patients. The dengue NS1 antigen detection (positive in all 10 patients with acute dengue fever) showed significantly higher sensitivity than the detection of viral RNA using RT-PCR (positive in 4 patients), p = 0.011. Although the vast majority of dengue fever cases are diagnosed among travellers returning from the tropics, the presented study points out the risks posed by dengue fever to long-term workers in endemic areas. The infection in the serologically naïve hosts is usually uncomplicated; however, infected persons are at significant risk of developing a severe complicated clinical course if challenged

  18. Alzheimer's disease and its treatment costs: case study in the Czech Republic.

    Science.gov (United States)

    Mohelska, Hana; Maresova, Petra; Valis, Martin; Kuca, Kamil

    2015-01-01

    This paper deals with the analysis of the costs, applied, for example, when treating specific diseases - an important aid in prioritizing the process of resource allocation. In our review, the specific disease is dementia caused by Alzheimer's disease. This paper aims to provide more information on the partial costs per patient that are calculated according to the aggregated data from publicly available sources as well as from the results of authors' own investigation. The University Hospital in Hradec Králové and the General Health Insurance Company of the Czech Republic participated in this research. The elementary research objective was to compare the costs per patient diagnosed early onset, to those of the patient diagnosed later. The Czech Republic lacks information regarding dementia. Therefore, these issues require attention. The methods used in this paper included time series analyses, methods of direct questioning, interviews with experts, and analyses of medical documentation. These methods were combined to exploit their particular advantages and to ensure the issues discussed, were covered. The investigation showed that the underpinning of patients with Alzheimer's disease at early onset is advantageous from an economic perspective, because the cost of outpatient care is much lower compared with that of inpatient care. The international comparisons of the volume of care provided should be approached with great caution. These are based solely on the facts of various expert estimates and are not usually supported by hard data. Yet, they still illustrate the overall view of our ability to take care of people with dementia. According to experts, care in the Czech Republic significantly lags behind the rest of developed Europe. While services are provided to 26% of people with dementia in Germany and 50% in France, the experts estimate that services are provided to only 10% of the population in the Czech Republic. If we were to offer a similar volume of

  19. NEW CZECH & CERTIFIED METHODOLOGY „TOOLS OF RESILIENCE“

    Directory of Open Access Journals (Sweden)

    Pavel DOBEŠ

    2017-12-01

    Full Text Available The article deals with possibilities of better governance regarding natural and anthropogenic risks and building of resilience of medium towns and cities against disasters. Such systematic approach could be applied for example using new Czech certified methodology “Tools Of Resilience”, which has been developed recently within the short project number no. VF20152016047 under the grant of Czech Ministry of the Interior in period 2015 - 2016 and afterwards certified in 2017 by Czech Ministry of the Environment. Basic starting points, used methods, steps of new methodology and its annexes, will be breafly described in the topic.

  20. Migration Behaviour of Strontium in Czech Bentonite Clay

    OpenAIRE

    Lucie Baborova; Dušan Vopálka; Eva Hofmanová; Aleš Vetešník

    2016-01-01

    The study deals with sorption and diffusion behaviour of strontium in Czech bentonite B75. The study is a part of a research on reactive transport of radioactive contaminants in barrier materials of a deep geological repository of radioactive waste in the Czech Republic. Series of sorption and diffusion experiments with Sr and non-activated Ca bentonite B75 produced in the Czech Republic were performed in two background solutions (CaCl2 and NaCl). On the basis of sorption batch experiments th...

  1. QTL mapping for production traits in Czech Fleckvieh cattle

    DEFF Research Database (Denmark)

    Matejickova, J; Stipkova, M; Sahana, Goutam

    2013-01-01

    The objective of this study was to find QTL for milk production traits in Czech Fleckvieh cattle on chromosomes 6, 7, 11, 14, and 23 where QTL were previously identified in other dairy cattle populations. Sixteen grandsire families were genotyped for 38 microsatellite markers on the selected...... of milk production in the Czech Fleckvieh cattle....... associated with milk production traits appeared on other studied chromosomes (BTA6, BTA7, BTA11, and BTA23). This first QTL search on five chromosomes in Czech Fleckvieh population showed several suggestive QTL that can be promising for further studies and contribute to better understanding of genetics...

  2. The economic burden of the care and treatment for people with Alzheimer's disease: the outlook for the Czech Republic.

    Science.gov (United States)

    Marešová, Petra; Zahálková, Veronika

    2016-12-01

    The aim of this paper is to specify the cost of treatment and care for people with Alzheimer's disease (AD) in the Czech Republic and also with a view to the future. Data availability is evaluated as well as the quality of cost comparison with other developed countries. Data for the Czech Republic will include data from the health insurance company regarding medicines and treatment, as well as a selected home caring for people with dementia and, ultimately, the Social Security Administration. The basic methods include an analysis of data from publicly available sources, direct interviews with the representatives of nursing homes caring for people with dementia and the representative of the Social Security Administration of the Czech Republic. Items will be specified within the category of direct costs. For the study, the indirect costs related to the loss of patient as well as caring person productivity are not considered. Costs for treatment and care are based from the data on 4162 patients, the costs of a bed from data on 391 beds in homes for the elderly. The average annual cost per patient with AD in the Czech Republic was calculated and came to the amount of 12,783 EUR. These items include outpatient care, inpatient care in a medical facility, inpatient care in homes and medications. In terms of share of these items on the direct costs, the largest item are services provided by special homes which contributes to the direct costs by 94 %, medications create 1 % and treatment (both outpatient and inpatient) 5 %. In the case of home care the total costs are lower at 4698 EUR. The Czech Republic as well as other developed countries are faced with the problem of unified accounting cost of people suffering from Alzheimer's disease. This then causes the calculation of the economic burden to be very difficult and indicative values.

  3. Selected English-Czech False Friends and Their Use in the Works of Some Czech Students

    Directory of Open Access Journals (Sweden)

    Daniel Raušer

    2017-05-01

    Full Text Available This paper serves mainly for practical study purposes and focuses on selected vocabulary taken from various Internet sources and subsequently put into wrong contexts by some Czech students of English at an institute of tertiary education, where the paper’s author is currently employed at the Department of Foreign Languages. When assessing the students’ oral presentations and submitted term papers, he very often encounters expressions the students borrow from English, yet incorrectly interpret as their semantic equivalents in the Czech language. Using these specifically opposing vocabularies, commonly referred to as “false friends”, account for repeatedly occurring mistakes made by the above students, who find some of these words confusing, displeasing and difficult to comprehend. Based on his subjective judgement and experience, the author selected several examples of such words in order to point out their particular discrepancies on applying them to both the English and Czech languages. By doing so, the author believes the students will avoid making mistakes, when searching and/or using their online references.

  4. Pressure Injuries in Inpatient Care Facilities in the Czech Republic: Analysis of a National Electronic Database.

    Science.gov (United States)

    Pokorná, Andrea; Benešová, Klára; Jarkovský, Jirˇí; Mužík, Jan; Beeckman, Dimitri

    The purpose of this study was to analyze pressure injury (PI) occurrence upon admission and at any time during the hospital course inpatients care facilities in the Czech Republic. Secondary aims were to evaluate demographic and clinical data of patients with PI and the impact of a PI on length of stay (LOS) in the hospital. Retrospective, cross-sectional analysis. The sample comprised data of hospitalized patients entered into the National Register of Hospitalized Patients (NRHOSP) database of the Czech Republic between 2007 and 2014 with a diagnosis L89 (pressure ulcer of unspecified site based on the International Classification of Diseases, Tenth Revision, ICD-10). Electronic records of 17,762,854 hospitalizations were reviewed. Data from the NRHOSP from all acute and non-acute care hospitals in the Czech Republic were analyzed. Specifically, we analyzed patients admitted to acute and non-acute care facilities with a primary or secondary diagnosis of PI. The NRHOSP database included 17,762,854 cases, of which 46,224 cases (33,342 cases in acute care hospitals; 12,882 in non-acute care hospitals) had the L89 diagnosis (0.3%). The mean age of patients admitted with a PI was 73.8 ± 15.3 years (mean ± SD), and their average LOS was 33.2 ± 76.9 days. The mean LOS of patients hospitalized with L89 code as a primary diagnosis (n = 6877) was significantly longer compared to those patients for whom L89 code was a secondary diagnosis (25.8 vs 20.2 days, P acute care facilities. In contrast, we found no difference in the mean LOS for patients hospitalized in non-acute care facility (58.7 days vs 65.1 days; P = .146) with ICD code L89. Pressure injuries were associated with significant LOS in both acute and non-acute care settings in the Czech Republic. Despite the valuable insights we obtained from the analysis of NRHOSP data, we advocate creation of a more valid and reliable electronic reporting system that enables policy makers to evaluate the quality and safety

  5. Congress of Slovak and Czech Osteologists: International Exchange of Experience

    Directory of Open Access Journals (Sweden)

    N. Kuprinenko

    2017-01-01

    Full Text Available Key highlights of reports of scientists from USA, Austria, Switzerland and Ukraine, that were presented in the Congress of Slovak and Czech Osteologists (8-10 of September, 2016, Zilina, Slovakia are described in this report.

  6. Describing Old Czech Declension Patterns for Automatic Text Analysis

    Czech Academy of Sciences Publication Activity Database

    Jínová, P.; Lehečka, Boris; Oliva jr., Karel

    -, č. 13 (2014), s. 7-17 ISSN 1579-8372 Institutional support: RVO:68378092 Keywords : Old Czech morphology * declension patterns * automatic text analysis * i-stems * ja-stems Subject RIV: AI - Linguistics

  7. Body conformation comparison of Czech and Polish Hucul horses

    Directory of Open Access Journals (Sweden)

    Zita Matoušová Malbohanová

    2004-01-01

    Full Text Available Measurements of 17 body measures and 11 indices of body conformation on 209 breeding individuals of the Hucul horse were used to analyse the effect of country of origin (Poland and the Czech Republic, sex (stallions and mares, age (5 classes and sire line (Gurgul, Goral, Oušor, Hroby, Polan, Pietrosu, Prislop. All horses were measured by one person. Measures and indexes were analysed by the GLM procedure. The main effect was the country of origin. Highly significant differences were found between both Polish and Czech horses in two thirds of measurements and in more than half of indices. The Czech Hucul horses are significantly higher, longer, wider in pelvis and have longer head than Polish horses. On the contrary to the Czech horses are Polish horses more compact, massive and have deeper chest. Their cannon bone in relation to height of wither is wider.

  8. SUSTAINABLE DEVELOPMENT AND ENVIRONMENTAL MANAGEMENT SYSTEMS IN THE CZECH REPUBLIC

    Directory of Open Access Journals (Sweden)

    Jaroslava Hyršlová

    2007-12-01

    Full Text Available The aim of the paper is to map the understanding of the sustainable development concept in Czech enterprise and to discuss the EMS significance for its promotion in business practice. The paper summarizes the research carried out in 2005 by the Czech Environmental Management Centre and by the Czech Environmental Information Agency. The paper aims at the understanding of sustainable development concept in business sphere, analyzing the level of EMS implementation in Czech enterprises and discussing essential advantages of EMS (as understood by the businesses for the promotion of sustainable development concept. Attention is paid to the use of other voluntary tools contributing to the promotion of this concept in business practice (mainly environmental accounting.

  9. Household flood risk reduction in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Duží, B.; Vikhrov, Dmytro; Kelman, I.; Stojanov, R.; Jakubínský, J.

    2015-01-01

    Roč. 20, č. 4 (2015), s. 499-504 ISSN 1381-2386 Institutional support: RVO:67985998 Keywords : flood risk reduction * household adaptation * Czech Republic Subject RIV: AH - Economics Impact factor: 3.085, year: 2015

  10. Household flood risk reduction in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Duží, B.; Vikhrov, Dmytro; Kelman, I.; Stojanov, R.; Jakubínský, J.

    2015-01-01

    Roč. 20, č. 4 (2015), s. 499-504 ISSN 1381-2386 Institutional support: PRVOUK-P23 Keywords : flood risk reduction * household adaptation * Czech Republic Subject RIV: AH - Economics Impact factor: 3.085, year: 2015

  11. An Energy Overview of the Czech Republic

    International Nuclear Information System (INIS)

    2003-01-01

    The DOE Office of Fossil Energy is maintaining a web site that is meant to provide useful business- and energy-related information about countries and regions of the world for exporters, project developers, and researchers. The site consists of more than 130 country pages (organized into seven different world regions), with each country page having its own set of links to information sources about that country. There are also more than 30 Country Energy Overviews at the web site -- each of these is a comprehensive review of a specific country's entire energy situation, including sections on Energy Policy, Oil, Natural Gas, Coal, Hydroelectric/Renewables, Nuclear Power, Energy Transmission Infrastructure, Electricity, Electric Industry Overview, Environmental Activities, Privatization, Trade, and Economic Situation. The specific country highlighted in this Country Energy Overview is the Czech Republic. The site is designed to be dynamic. Updates to the overviews will be made as need an d resources permit

  12. Wind Turbines in Tourism Landscaspes: Czech Experience

    Czech Academy of Sciences Publication Activity Database

    Frantál, Bohumil; Kunc, Josef

    2011-01-01

    Roč. 38, č. 2 (2011), s. 499-519 ISSN 0160-7383 R&D Projects: GA AV ČR(CZ) KJB700860801 Institutional research plan: CEZ:AV0Z30860518 Keywords : wind energy * lanscape * perception * Czech Republic Subject RIV: DE - Earth Magnetism, Geodesy, Geography Impact factor: 3.259, year: 2011 http://www. science direct.com/ science ?_ob=MiamiImageURL&_cid=271796&_user=4955814&_pii=S0160738310001271&_check=y&_origin=&_coverDate=30-Apr-2011&view=c&wchp=dGLbVlS-zSkWz&md5=2777f7fff0ea7807aadfe0014ace0683/1-s2.0-S0160738310001271-main.pdf

  13. Risk Premia in the Czech Money Market

    Directory of Open Access Journals (Sweden)

    Martin Pohl

    2013-01-01

    Full Text Available We estimate risk premia in the Czech money market and we pay special attention to the 2008-2009 crisis period. Our results imply a rising forward premium and we argue that the error correction model is the most appropriate method, but median may be used as a first guess estimator. We estimated the term premium between the policy rate and various money market interest rates. In this context, ARCH models proved to be useful in reflection of non-stationarity observed in the data. The financial crisis caused a structural break in our data sample, but the impact on the forward premium was only brief and forward premia normalized quickly. The widening of the term premium proved to be much more persistent, although it declined significantly since the peak of the crisis.

  14. Desulphurisation of waste gases in Czech Republic

    Directory of Open Access Journals (Sweden)

    Svrèek Peter

    1998-09-01

    Full Text Available The paper deals with the problem of the decreasing sulphur dioxide emission in the Czech Republic. In 1991 a new Cean Air Act has been accepted. Emission limit values based on the best available technology not entailing cost. All sources of pollution will have to comply the emission limit values up to December 31, 1998 at the latest. At the present time the last units in the power plants and heating plants are under construction, many of them are on the scale. The prevailing system is the wet limestone technology producing gypsum. Differences in the installed systems, in particular power plants, are described. In a lesser extent the wet dry lime technology will be used. Old boilers are replaced by the atmospheric fluidized bed combustion. At the end of the paper the proposal of the amendment to the Europe Union Directive 608/87 EEC, is discussed. Differences in the systems in the particular power plants are described.

  15. New electricity generating installations - Czech experience

    International Nuclear Information System (INIS)

    Biza, K.; Pazdera, F.; Zdarek, J.

    2004-01-01

    Economically and technically are analysed alternatives for new electricity generation installations (GEN 111+ NPPs, finalization of NPPs under construction, lifetime extension of existing NPPs, coal plants and gas plants). Described are experienced with NPP Temelin (lessons learned from its design, construction, start-up and resent operation and service experience) and new Czech Energy Policy, where the nuclear energy is an important source for electricity generation. Discussed is also impact of potential trading with CO 2 limits and strategy on minimization of dependence on energy from politically unstable regions. Underlined is important role of preparation of young generation for safe and reliable long term operation of NPPs. General recommendation is to orient on finalization of NPPs under construction, lifetime extension of existing NPPs and long term orientation on new generation of NPPs (GEN III+ and GEN IV). (author)

  16. Wind Turbines in Tourism Landscaspes: Czech Experience

    Czech Academy of Sciences Publication Activity Database

    Frantál, Bohumil; Kunc, Josef

    2011-01-01

    Roč. 38, č. 2 (2011), s. 499-519 ISSN 0160-7383 R&D Projects: GA AV ČR(CZ) KJB700860801 Institutional research plan: CEZ:AV0Z30860518 Keywords : wind energy * lanscape * perception * Czech Republic Subject RIV: DE - Earth Magnetism, Geodesy, Geography Impact factor: 3.259, year: 2011 http://www.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271796&_user=4955814&_pii=S0160738310001271&_check=y&_origin=&_coverDate=30-Apr-2011&view=c&wchp=dGLbVlS-zSkWz&md5=2777f7fff0ea7807aadfe0014ace0683/1-s2.0-S0160738310001271-main.pdf

  17. The environment and energy sector in the Czech republic

    International Nuclear Information System (INIS)

    2004-08-01

    The objective of this report is to give Danish investors, consultants, and subcontractors With interest in the Czech environment and energy sector, a basis for evaluating its market opportunities. Furthermore, the report will provide the reader With an overview of potential finance sources for projects within the environment and energy sector. With the prospects of EU membership, the Czech Republic has put a great effort into improving the country's environmental conditions as well as restructuring its energy sector. In particular in the area of the environment, the Czech Republic has experienced considerable progress. However, in several environmental areas, the Czech Republic is still lacking behind other EU countries. The process of meeting the environmental standards of the EU continues to demand large investments, especially within the field of water and waste treatment. In the process of adapting to the requirements of the EU in the field of the environment, the Czech Republic can expect to receive around EUR 615 million in EU funds betaveen 2004 and 2006. The Czech energy sector is the most air-polluting sector in the country and there is a general demand for knove-hove and technology in the field of energy efficiency and udlisation of renewable energy. Renewable energy makes up only 2% of the Czech Republic's total energy production. The goal of the Czech government is to increase the share to 8% before 2010. This report illustrates hove the large investments required in the area of environment and energy combmed with a wide range of national and international financing opportunities open up for significant market opportunities in the Czech Republic for Danish companies specialised within the environment and energy sector. As a foundation of the report there will first be a brief explanation of the inarket conditions in the Czech Republic. Secondly, the report will describe the environmental sector in depth within the areas water, waste, and air, and

  18. [Temporal aspects of the Czech retirement age].

    Science.gov (United States)

    Rabusic, L

    1998-01-01

    The retirement age in the Czech Republic was 60 years for men and 55 years for women until 1995, when a law was passed to gradually increase it every year until it reached 62 years for men and 59 for women by the year 2007. The reason for increasing the retirement age is the rapid increase in life expectancy since 1990 (a gain of 3 years for males between 1990 and 1997) and the fact that a relatively low retirement age may result in social discrimination against Czechs within a unified Europe. A social survey was conducted in November 1996 using a representative population sample of 1302 persons aged 50 years or more. The average retirement age for women was 55.4 years and for men 60.2 years. The majority of respondents irrespective of social class, educational level, and gender did not want an increase in the retirement age, confirming the results of polls conducted during 1995 and 1996. 25% of economically active respondents aged 50-59 (almost half of them with university degrees and 37% from cities) intended to continue working. 72% of the respondents 60 and over retired at the retirement age, 6% retired earlier, and 22% retired later. Only 40% of the elderly retired willingly (women more often than men). Among the rest 24% were hesitant about retirement, 21% did not want to retire but felt compelled to do for health reasons (men more often than women), and 15% did not want to retire, but their firms did not need them any more (men more often than women). The male respondents stated on average that a person was old when he reached 67.8 years, while female respondents on average deemed that 66.1 years represented old age. The increase of the retirement age to 65 is anticipated in the next 10-15 years.

  19. Comparative advertisemenet - the development of its regulation in Czech law

    OpenAIRE

    Šmukařová, Kateřina

    2010-01-01

    Resumé The aim of the thesis "Comparative advertising - the development of its regulation in Czech law" is to analyze the development of comparative advertising in the Czech legislation, to make a comparison with the EU legislation and to examine development trends in comparative advertising. The thesis is divided into four key parts. First part discusses general issues of comparative advertising, ways of comparison in advertising, understanding of comparative advertising in the past and gene...

  20. Home bias in sport betting: Evidence from Czech betting market

    OpenAIRE

    Rostislav Staněk

    2017-01-01

    In sport betting, bettors exhibit home bias when they tend to bet on their home team more often. The paper offers a straightforward method of empirical identification of the home bias in the real-world betting market. Using Czech betting data on the league and the national ice-hockey matches, the paper provides support for the existence of the home bias in the Czech betting market.

  1. Minimum wage in the Czech Republic and European Union

    OpenAIRE

    Šmíd, Marek

    2013-01-01

    The Master's thesis deals with analysis of the minimum wage in the Czech Republic and European Union. The first three chapters describe the function and development of the minimum wage, as well as the theoretical approaches of the minimum wage. Furthermore the arguments for and against the minimum wage are summarized. In the practical part the development of the minimum wage in the Czech Republic from 1991 is analyzed and the minimum wage across the EU countries is compared. The last analysis...

  2. The Economic Value of Crop Diversity in the Czech Republic

    OpenAIRE

    Tyack, Nicholas

    2016-01-01

    We estimate the willingness-to-pay for conserving crop diversity in the Czech Republic. Discrete choice experiments are used to elicit preferences for the conservation of wine, hop, and fruit tree varieties, while a double-bounded dichotomous choice approach is used to elicit preferences for the conservation of unspecified, "general" crop diversity. The WTP values are derived for both of these contingent products from a sample representative of the general Czech population (n=731) and a sampl...

  3. Written communication and teaching of the czech language for foreigners

    OpenAIRE

    Toufarová, Dagmar

    2015-01-01

    In her thesis the author looks at written communication in teaching Czech for foreigners. The theoretical part gives an account of theoretical foundations, such as synchronic and diachronic approaches to the language situation (worldwide, in Europe and especially in the Czech Republic) and language education, including introduction to communicative methods. Furthermore, the author describes individual component parts of the language education (means of expression and communication skills), wi...

  4. Board games used for teaching Czech in Primary Schools

    OpenAIRE

    Novotná, Klára

    2017-01-01

    The main aim of this diploma thesis is to make a contribution to discussion about suitability of using board games in education and to confirm that making use of board games is a valid didactical method used for teaching Czech language. Theoretical part is focused on play and game, making use of games in education, board games, their characteristics, categories, types and utilization in education. Following chapters explore advantages and disadvantages of using board games for teaching Czech ...

  5. The club development of american football in the Czech Republic

    OpenAIRE

    Dundáček, Jan

    2015-01-01

    Title: The club development of american football in the Czech Republic In the first part of this thesis American football is introduced, explaining basic game principles and describing the game so that the reader can imagine what the sport is all about. The second part then focuses on examining the emergence of particular American football clubs in the Czech Republic. The whole period is divided into several stages, with a strong focus on finding a common denominator of individual events. The...

  6. Compilation of Non-Financial Balances in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Vítězslav Ondruš

    2011-09-01

    Full Text Available The System of National Accounts in the Czech Republic consists of three main parts — institutional sector accounts, input-output tables and balances of non-financial assets. All three parts are compiled interactively by common time schedule. The article deals with balances of non-financial assets and their relation to core institutional sector accounts and explains why the third parallel part of SNA in the Czech Republic was build, describes its weaknesses and future development.

  7. Convergence of Market Concentration: Evidence from Czech Food Processing Sectors

    OpenAIRE

    I.

    2016-01-01

    The aim of the paper is to evaluate the market concentration in the Czech food and beverages industry over the period of 2003-2014, to quantify disparities among particular sectors and to investigate the trend of market concentration. The concept of convergence is applied when investigating the trend in the long term. The market concentration in the Czech food and beverages industry has increased on average. In sectors with relatively low market concentration in 2003, the values of concentrat...

  8. Tangible fixed assets in Czech accounting regulation and International standards

    OpenAIRE

    Vojířová, Tereza

    2015-01-01

    In my bachelor thesis, I will discuss the comparison of reporting of tangible fixed assets in according Czech accounting regulation and according to International Financial Reporting Standards. In the first part the tangible fixed assets are described according to the Czech legal accounting regulation. After that are defined the main differences in reporting of tangible fixed assets in comparison with IFRS. In next part I focus on the specific issue of reporting tangible fixed assets in real ...

  9. Football Hooligans in the Czech Republic: Selected Topics

    OpenAIRE

    Smolík, Josef

    2012-01-01

    Since the 1990s organized groups have begun to appear in the Czech Republic called „football hooligans”. These groups have drawn the attention of the media, security forces, officials of the Czech Republic Football Association, and the broader public. This text focuses on selected topics associated with the phenomenon of football hooliganism. After a brief history of football hooliganism abroad, especially in England, it will describe the current status of this phenomenon in...

  10. The Perception of the PUMA Brand in the Czech Market

    OpenAIRE

    Martínková, Kateřina

    2017-01-01

    The ambition of this master thesis is to provide a deeper insight into a marketing strategy of the multinational company PUMA applied in the Czech Republic. Specifically, the thesis includes a survey of customers designed to examine the perception of the PUMA brand in the Czech market within the target group of people from 16 to 26 years old. One of the essential requirements of this thesis is to provide a very important theoretical background of the marketing field, explaining the basic mark...

  11. External events analysis in PSA studies for Czech NPPs

    International Nuclear Information System (INIS)

    Holy, J.; Hustak, S.; Kolar, L.; Jaros, M.; Hladky, M.; Mlady, O.

    2014-01-01

    The purpose of the paper is to summarize current status of natural external hazards analysis in the PSA projects maintained in Czech Republic for both Czech NPPs - Dukovany and Temelin. The focus of the presentation is put upon the basic milestones in external event analysis effort - identification of external hazards important for Czech NPPs sites, screening out of the irrelevant hazards, modeling of plant response to the initiating events, including the basic activities regarding vulnerability and fragility analysis (supported with on-site analysis), quantification of accident sequences, interpretation of results and development of measures decreasing external events risk. The following external hazards are discussed in the paper, which have been addressed during several last years in PSA projects for Czech NPPs: 1)seismicity, 2)extremely low temperature 3)extremely high temperature 4)extreme wind 5)extreme precipitation (water, snow) 6)transport of dangerous substances (as an example of man-made hazard with some differences identified in comparison with natural hazards) 7)other hazards, which are not considered as very important for Czech NPPs, were screened out in the initial phase of the analysis, but are known as potential problem areas abroad. The paper is a result of coordinated effort with participation of experts and staff from engineering support organization UJV Rez, a.s. and NPPs located in Czech Republic - Dukovany and Temelin. (authors)

  12. CLINICAL, EPIDEMIOLOGIC, AND ENDOSCOPIC PROFILE IN CHILDREN AND ADOLESCENTS WITH COLONIC POLYPS IN TWO REFERENCE CENTERS

    Directory of Open Access Journals (Sweden)

    Denise O ANDRADE

    2015-12-01

    Full Text Available Background - The main goal of this paper is to investigate the frequency, clinical profile, and endoscopic findings of children and teenagers submitted to colonoscopies. Methods - Patients of below 18 years of age, diagnosed with polyps by means of colonoscopies at two reference centers of pediatric endoscopy were followed-up between 2002 and 2012. The clinical variables evaluated in this study included: gender, recommendation of colonoscopy, associated signs and symptoms, age of onset of symptoms, age at identification of the polyp, interval of time between the onset of symptoms and the endoscopic diagnosis of colonic polyps, and family history of intestinal polyposis and/or colorectal cancer. The characteristics of the polyps also included: number, morphological type, histology, and distribution. Polyposis syndromes were also investigated. Results - From the 233 patients submitted to colonoscopies, polyps were found in 74 (31.7% patients, with a median age of 6.6 years, of which 61% were male. Juvenile polyps were identified in 55 (74% patients, with 7 (9% characterized within the criteria for juvenile polyposis. Patients with intestinal polyposis syndromes were diagnosed in 35% of the patients. The most frequent clinical presentation was hematochezia. Abdominal pain with acute episodes of intestinal partial obstruction or intussusception with emergency laparotomy was observed in the majority of Peutz-Jeghers syndrome patients leading to an increased morbidity. Conclusions - Even though juvenile colonic polyps are the most frequent type of diagnosed polyps, the present study identified a significant level of children with polyposis syndromes (35%, associated with a higher morbidity of these individuals.

  13. Use of Aromatase Inhibitors in Large Cell Calcifying Sertoli Cell Tumors: Effects on Gynecomastia, Growth Velocity, and Bone Age

    Science.gov (United States)

    Crocker, Melissa K.; Gourgari, Evgenia; Stratakis, Constantine A.

    2014-01-01

    Context: Large cell calcifying Sertoli cell tumors (LCCSCT) present in isolation or, especially in children, in association with Carney Complex (CNC) or Peutz-Jeghers Syndrome (PJS). These tumors overexpress aromatase (CYP19A1), which leads to increased conversion of delta-4-androstenedione to estrone and testosterone to estradiol. Prepubertal boys may present with growth acceleration, advanced bone age, and gynecomastia. Objective: To investigate the outcomes of aromatase inhibitor therapy (AIT) in prepubertal boys with LCCSCTs. Design: Case series of a very rare tumor and chart review of cases treated at other institutions. Setting: Tertiary care and referral center. Patients: Six boys, five with PJS and one with CNC, were referred to the National Institutes of Health for treatment of LCCSCT. All patients had gynecomastia, testicular enlargement, and advanced bone ages, and were being treated by their referring physicians with AIT. Interventions: Patients were treated for a total of 6–60 months on AIT. Main Outcome Measures: Height, breast tissue mass, and testicular size were all followed; physical examination, scrotal ultrasounds, and bone ages were obtained, and hormonal concentrations and tumor markers were measured. Results: Tumor markers were negative. All patients had decreases in breast tissue while on therapy. Height percentiles declined, and predicted adult height moved closer to midparental height as bone age advancement slowed. Testicular enlargement stabilized until entry into central puberty. Only one patient required unilateral orchiectomy. Conclusions: Patients with LCCSCT benefit from AIT with reduction and/or elimination of gynecomastia and slowing of linear growth and bone age advancement. Further study of long-term outcomes and safety monitoring are needed but these preliminary data suggest that mammoplasty and/or orchiectomy may be foregone in light of the availability of medical therapy. PMID:25226294

  14. Adenoma malignum of the uterine cervix - Imaging features with clinicopathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sung Bin [Dept. of Radiology, Chung-Ang Univ. Hospital, Chung-Ang ne, Seoul (Korea, Republic of); Dept. of Radiology, Cheil General Hospital and Women' s Healthcare Center, Kwandong Univ. Coll. of Medicine, Seoul (Korea, Republic of)], e-mail: pksungbin@paran.com; Lee, Young Ho; Song, Mi Jin [Dept. of Radiology, Cheil General Hospital and Women' s Healthcare Center, Kwandong Univ. Coll. of Medicine, Seoul (Korea, Republic of); Lee, Jong Hwa [Dept. of Radiology, Ulsan Univ. Hospital, Univ. of Ulsan, Ulsan (Korea, Republic of); Lim, Kyung Taek [Dept. of Obstetrics and Gynecology, Cheil General Hospital and Women' s Healthcare Center, Kwandong Univ. Coll. of Medicine, Seoul (Korea, Republic of); Hong, Sung Ran [Dept. of Pathology, Cheil General Hospital and Women' s Healthcare Center, Kwandong Univ. Coll. of Medicine, Seoul (Korea, Republic of); Kim, Jeong Kon [Dept. of Radiology and Research Inst. of Radiology, Asan Medical Center, Univ. of Ulsan, Seoul (Korea, Republic of)

    2013-02-15

    Background: Adenoma malignum, also known as minimal deviation adenocarcinoma, is a subtype of mucinous adenocarcinoma of the cervix. Purpose: To evaluate the clinical, pathologic, and imaging features of the adenoma malignum of the uterine cervix. Material and Methods: We retrospectively analyzed the CT and MRI findings in 13 patients: size, endoluminal fluid, appearance of the solid and cystic component, margin, enhancement, characteristics of locules of the cystic lesion, tumor spread, and associated ovarian lesion. Clinical and pathologic features were determined in 24 patients. Results: The mean of the major tumor diameter was 4.1 cm (range, 2.2 - 6.5 cm). In the imaging features, 77% of 13 tumors demonstrated endoluminal fluid. All tumors showed enhancing solid components; 62% were multicystic and 38% had solid lesions. Most solid lesions exhibited an irregular margin (80%). The locules of the multicystic lesions tended to have smooth margins (75%), to have an average major diameter of {<=}1 cm (88%), and to be 11 - 20 in number (75%). The solid lesions were associated with invasion and metastases (60%). Clinically, 38% of 24 patients had watery discharge and 13% had Peutz-Jeghers syndrome, while pathologically, most patients were low stage (I or II) (83%). Over the 2-year follow-up of 17 patients, 82% was free from disease. The patients with more aggressive tumors or an unfavorable prognosis that manifested as tumor recurrence or metastasis tended to have invasion, watery discharges, high stages (III or IV) (100%) and solid lesions, metastases, and associated ovarian lesions (67%). Conclusion: Awareness of imaging features as well as clinicopathologic manifestations of adenoma malignum can aid in accurate diagnosis, treatment, and prediction of prognosis.

  15. Academic education in addictology (addiction science in the Czech Republic: Analysis of the (pre-1989 historical origins

    Directory of Open Access Journals (Sweden)

    Miovsky Michal

    2015-12-01

    Full Text Available BACKGROUND - In the Czech Republic, education in addiction science consists of a distinctive and interconnected system of non-medical healthcare education on the Bachelor’s (Bc and Master’s (MA levels, followed by a doctoral study programme (PhD. Addictology (addiction science as a new term is defined as a distinct and independent field of scientific inquiry on addictive behaviours and the risk environment of substance use, aiming at scientific and professional excellence relevant to society. AIMS - This case study seeks to identify, describe and explain important events in shaping the historical context of the Czech education and research programmes in addictology. DESIGN - The historical review is based on qualitative content analysis of central written documents. RESULTS - In the 19th century Czech territory, problematic alcohol use was addressed through self-help activities in the second half of the nineteenth century. During the 1950s and 1960s, a new generation of Czech psychiatrists emerged with an interest in alcohol treatment and in research of hallucinogenic drugs. A patient education bulletin Apolinárský zápisník [Apolinar Diary] was launched in 1951 and was later also used for education of treatment professionals in connection with other self-help and quasi-self-help activities. The monographs Alkoholism (1957 and Toxicomany (1973 conceptualised the core of abstinence-oriented historical traditions and developments. A separation of approaches to legal and illegal drugs can be observed in the 1970s. In 1967, a new and intensive training model was introduced for psychiatrists and psychotherapists, leading into specialisation in psychotherapy and addiction. Because of the Iron Curtain, Czech practitioners had to develop their own concept of addiction and ideas on training psychotherapists so they could not be labelled western or anti-state, or be subject to intense state control.

  16. Familial Follicular-Cell Derived Carcinoma

    Directory of Open Access Journals (Sweden)

    Eun Ju eSon

    2012-05-01

    Full Text Available Follicular cell-derived well-differentiated thyroid cancer, papillary (PTC and follicular thyroid carcinomas (FTC compose 95% of all thyroid malignancies. Familial follicular cell-derived well-differentiated thyroid cancers contribute to 5% of those cases. These familial follicular cell derived carcinomas or non-medullary thyroid carcinomas (NMTC divide into two clinical-pathological groups. One group, syndromic-associated, composed by predominately non-thyroidal tumors, is comprised of Pendred syndrome, Warner syndrome, Carney complex type 1, PTEN-hamartoma tumor syndrome (Cowden disease; PHTS, familial adenomatous polyposis (FAP/Gardner syndrome. Additionally other less established links correlated to the development of follicular cell-derived tumors have also included Ataxia-teleangiectasia syndrome, McCune Albright syndrome, and Peutz-Jeghers syndrome. The subsequent group encompasses syndromes typified by non-medullary thyroid carcinomas or NMTC, as well as, pure familial (f PTC with or without oxyphilia, fPTC with multinodular goiter and fPTC with papillary renal cell carcinoma. This heterogeneous group of diseases has not a established genotype-phenotype correlation as the well-known genetic events identified in the familial C-cell-derived tumors or medullary thyroid carcinomas (MTC. Clinicians should be have the knowledge to identify the likelihood of a patient presenting with thyroid cancer having an additional underlying familial syndrome stemming from characteristics through morphological findings that would alert the pathologist to have the patient undergo subsequent molecular genetics evaluations. This review will discuss the clinical and pathological findings of the patients with familial papillary thyroid carcinoma, such as familial adenomatous polyposis, Carney complex, Werner syndrome, and Pendred syndrome and the heterogeneous group of familial papillary thyroid carcinoma.

  17. The Czech Republic programme and experiences on training and qualification for NPPs personnel

    International Nuclear Information System (INIS)

    Kovar, P.

    1993-01-01

    The nuclear power programme in Czech Republic is based on commercial use of WWER-type reactors. This document discusses future scope of nuclear programme in Czech Republic and status of training programme for NPP personnel

  18. Dengue fever in Czech travellers: A 10-year retrospective study in a tertiary care centre.

    Science.gov (United States)

    Trojánek, Milan; Maixner, Jan; Sojková, Naděžda; Kynčl, Jan; Roháčová, Hana; Marešová, Vilma; Stejskal, František

    2016-01-01

    Dengue fever is a frequent cause of morbidity in travellers. The objective was to describe the epidemiological and clinical characteristics of dengue fever in Czech travellers. This descriptive study includes patients with acute dengue fever diagnosed at Hospital Na Bulovce during 2004-2013. Data were collected and analysed retrospectively. A total of 132 patients (83 males and 49 females) of median age 33 years (IQR 29-40) were included. Diagnosis was established by NS1 antigen detection in 87/107 cases (81.3%) and/or RT-PCR in 50/72 (69.4%) and by serology in 25 cases (18.9%). Dengue was acquired in South-East Asia in 69 cases (52.3%), followed by South Asia (48 cases; 36.3%), Latin America (14; 10.6%) and Sub-Saharan Africa (1; 0.8%). The most frequent symptoms included fever, rash and headache. Initial leukocyte and lymphocyte counts were lower in patients who presented in the early phase (0-4 days), however, platelet count was lower and AST, ALT and LDH activity higher in patients with a longer symptoms duration (≥5 days). The clinical course was mostly uncomplicated. Dengue fever is becoming a frequent cause of fever in Czech travellers. Clinicians should be familiar with the typical clinical findings and novel diagnostic methods. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Efficiency Evaluation of Hospitals in the Environment of the Czech and Slovak Republic

    Directory of Open Access Journals (Sweden)

    Stanislav Sendek

    2015-01-01

    Full Text Available The paper applies the Data Envelopment Analysis as a deterministic non-parametric method based on the linear programming, to measure the efficiency of Czech and Slovak hospitals based on input and output performance. Managing physician or hospital practice patterns is an important tool to reduce health care costs. State-run hospitals, as decision-making units working in an operating healthcare system, might have some excess resources in the process of providing care. Ehealth tools are expected to contribute to the cost containment in them, enhancing finally the quality of patient care in the overall assessment.

  20. The Czech Republic: Workplace abuse in a post-transitional country

    OpenAIRE

    Zábrodská, K. (Kateřina); Květon, P. (Petr)

    2016-01-01

    This chapter addresses workplace abuse in the transforming nation of the Czech Republic. The Czech Republic is a Central Eastern European country, whose development was significantly hampered by 40 years of communist rule (1948–1989). The current work environment in the Czech Republic continues to be shaped by the legacy of the communist workplace culture as well as the recent expansion of neoliberalism and individualism. Using their own research into workplace bullying in Czech academia as a...

  1. Effects of the Financial Crisis on Stock Market of the Czech Republic and Spain

    OpenAIRE

    Titizov, Toško

    2013-01-01

    The paper analyzes effects of the financial crisis on stock market of the Czech Republic and Spain. We employ BEKK-GARCH model in order to study volatility spillovers and transmissions from the US stock market to stock markets of the Czech Republic and Spain. The multivariate GARCH models results show statistically significant, but relatively small, almost irrelevant volatility spillovers from the US stock market to stock markets of the Czech Republic and Spain. The Czech stock market exhibit...

  2. Marketingová komunikace agentury CzechTourism - internetový marketing DCR

    OpenAIRE

    Soukupová, Tereza

    2012-01-01

    The theoretical part includes the basic rules of marketing, set in the context of tourism through marketing the competitive destination, and internet marketing. The following chapters focus on the role of the CzechTourism in the field of tourism in the Czech Republic. Describe CzechTourism's marketing plans, including marketing campaign to promote domestic tourism. In the end the work focuses on the internet marketing through a basic analysis of the Czech domestic tourism website's homepage (...

  3. Hereditary intestinal polyposis syndromes.

    Science.gov (United States)

    Dean, P A

    1996-01-01

    Colorectal cancer is one of the most common cancers in the world, with overall mortality exceeding 40% even with treatment. Effective efforts for screening and prevention are most likely to succeed in patient groups identified as high risk for colorectal cancer, most notably the hereditary intestinal polyposis syndromes. In these syndromes, benign polyps develop throughout the intestinal tract prior to the development of colorectal cancer, marking the patient and associated family for precancer diagnosis followed by either close surveillance or preventive treatment. This review article was undertaken to discuss the most recent developments in the knowledge of hereditary intestinal polyposis syndromes, emphasizing the clinical approach to diagnosis and treatment relative to preventing the development of cancer. The most common of the hereditary polyposis syndromes is familial adenomatous polyposis (FAP), which is characterized by the development of hundreds to thousands of adenomatous polyps in the colon followed at an early age by colorectal cancer. Colorectal cancer can be prevented in this autosomal dominant condition by prophylactic colectomy, though a risk for other tumors, including periampullary cancers, remains throughout life. Variant of FAP associated with fewer and smaller polyps (hereditary flat adenoma syndrome), or even CNS tumors (Turcot's syndrome) also carry this high risk of colorectal cancer. Hereditary hamartomatous polyposis syndromes such as juvenile polyposis and Peutz-Jeghers syndrome (also autosomal dominant) are characterized by less frequent polyps. Though these are generally benign polyps, they are also associated with a significant risk of colorectal and other cancers. Other polyposis syndromes, including neurofibromatosis and Cowden's disease, do not carry this increased risk of colorectal cancer, and therefore affect different treatment strategies. Analysis of genetic factors responsible for these and other hereditary syndromes with

  4. Enteroclysis in older children and teenagers

    Energy Technology Data Exchange (ETDEWEB)

    Kurugoglu, Sebuh; Korman, Ugur; Adaletli, Ibrahim; Selcuk, Dogan [Istanbul University, Department of Radiology, Cerrahpasa Medical Faculty, Istanbul (Turkey)

    2007-05-15

    Enteroclysis (EC) has been widely and successfully used for evaluation of the small bowel in adults for about 30 years. However, despite recently improved intubation and examination techniques, in many paediatric radiology centres it is still not the preferred conventional barium study for the evaluation of small bowel pathology in children. To share our 10 years of experience and review the feasibility of EC in 83 older children and teenagers, in terms of both technique and pathological findings. Between 1996 and 2006, EC was performed by the standard technique described by Herlinger to 83 children between 7 and 18 years of age. The indication for the study was jointly decided by the paediatric radiologist and the clinician. None of the examinations was converted to follow-through studies because of patient refusal or technical failure. Morphological changes, mucosal abnormalities, luminal abnormalities, perienteric structures, the location of the disease, indirect findings regarding the bowel wall and functional information were evaluated. All the children tolerated the procedure without difficulty. Out of 83 patients, 63 had abnormal findings. The spectrum of diagnoses were Crohn disease (n = 23), nonspecific enteritis (n = 10), malabsorption (n = 8), intestinal tuberculosis (n = 6), intestinal lymphoma (n = 5), Peutz-Jegher syndrome (n = 3), adhesions (n = 2), Behcet disease (n = 2), back-wash ileitis due to ulcerative colitis (n = 2), common-variable immune deficiency (n = 1) and lymphangiectasis (n = 1). EC can easily be performed in children over 7 years of age and when performed using a correct technique it shows high diagnostic performance without any complications in the evaluation of small bowel diseases in older children and teenagers. (orig.)

  5. Enteroclysis in older children and teenagers

    International Nuclear Information System (INIS)

    Kurugoglu, Sebuh; Korman, Ugur; Adaletli, Ibrahim; Selcuk, Dogan

    2007-01-01

    Enteroclysis (EC) has been widely and successfully used for evaluation of the small bowel in adults for about 30 years. However, despite recently improved intubation and examination techniques, in many paediatric radiology centres it is still not the preferred conventional barium study for the evaluation of small bowel pathology in children. To share our 10 years of experience and review the feasibility of EC in 83 older children and teenagers, in terms of both technique and pathological findings. Between 1996 and 2006, EC was performed by the standard technique described by Herlinger to 83 children between 7 and 18 years of age. The indication for the study was jointly decided by the paediatric radiologist and the clinician. None of the examinations was converted to follow-through studies because of patient refusal or technical failure. Morphological changes, mucosal abnormalities, luminal abnormalities, perienteric structures, the location of the disease, indirect findings regarding the bowel wall and functional information were evaluated. All the children tolerated the procedure without difficulty. Out of 83 patients, 63 had abnormal findings. The spectrum of diagnoses were Crohn disease (n = 23), nonspecific enteritis (n 10), malabsorption (n = 8), intestinal tuberculosis (n = 6), intestinal lymphoma (n = 5), Peutz-Jegher syndrome (n = 3), adhesions (n = 2), Behcet disease (n 2), back-wash ileitis due to ulcerative colitis (n = 2), common-variable immune deficiency (n = 1) and lymphangiectasis (n = 1). EC can easily be performed in children over 7 years of age and when performed using a correct technique it shows high diagnostic performance without any complications in the evaluation of small bowel diseases in older children and teenagers. (orig.)

  6. Prader-Willi syndrome due to an unbalanced de novo translocation [t(15;19)(q12;p13.3)

    Science.gov (United States)

    Dang, Vy; Surampalli, Abhilasha; Manzardo, Ann M; Youn, Stephanie; Butler, Merlin G; Gold, June-Anne; Kimonis, Virginia

    2018-01-01

    Background and Aims Prader-Willi syndrome (PWS) is a complex, multisystem genetic disorder characterized by endocrine, neurologic and behavioral abnormalities. We report the first case of an unbalanced de-novo reciprocal translocation of chromosome 15 and 19: 45,XY,-15, der (19)t(15;19)(q12;p13.3) resulting in monosomy for the PWS chromosome critical region. We performed high resolution SNP microarray to characterize the breakpoints. Case report Our patient had several typical features for PWS including infantile hypotonia, a poor suck and feeding difficulties, tantrums, skin picking, compulsions, small hands and feet and food seeking but not hypopigmentation, a micropenis, cryptorchidism or obesity as common findings seen in PWS at the time of examination at 6 years of age. He had seizures noted from 1 to 3 years of age and marked cognitive delay. Results High resolution SNP microarray analysis identified an atypical PWS Type I deletion of chromosome 15 involving proximal breakpoint BP1. The deletion extended beyond the GABRB3 gene but was proximal to the usual distal breakpoint (BP3) within the 15q11-q13 region and GABRA5, GABRG3 and OCA2 genes were intact. Conclusion We report a case with atypical features for PWS associated with an unbalanced de-novo reciprocal translocation resulting in monosomy for the 15q11.1–15q12 with intact GABRA5, GABRG3 and OCA2 genes. No deletion of 19p13.3 band was detected therefore the patient was not at an increased risk of tumors from Peutz-Jeghers syndrome associated with a deletion of the STK11 gene. PMID:27894106

  7. Influencing youth entrepreneuship in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Monika Fantová

    2017-12-01

    Full Text Available Entrepreneurship is one of the possible solutions to the pan-European problem of youth unemployment. The objective of the research was to identify differences between male and female entrepreneurs in their opinions of entrepreneurship of young people. We wanted to find out whether male and female entrepreneurs would recommend young people to do business and what factors in their opinion can influence the fact whether young people start business. To collect data, we used a questionnaire sent to entrepreneurs from the whole Czech Republic. The most important barrier identified by entrepreneurs was frequently amended legislation, complexity of administration, poor enforceability of law and a lack of funds. The most important incentives of young people according to entrepreneurs is particularly the vision of opportunities in business. Another important incentive is becoming more independent. Statistically significant differences in the responses of men and women were found in the barrier related to the personal knowledge of an unsuccessful entrepreneur and in the incentive of the necessity to start business due to the lack of a job. Sufficient funding and possessing business premises were factors in which statistically significant differences in the responses of men and women were found, too. This research emphasises factors which women and men can find important in making a decision on starting business or being employed.

  8. Determinants of Regional Entrepreneurial Activity in the Czech Republic

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    Ondřej Dvouletý

    2016-07-01

    Full Text Available The following study is focused on analysis of registered businesses in the 14 regions of the Czech Republic during the period of years 1995-2013. The aim of the study was to quantify factors that affect entrepreneurial activity expressed as rate of registered businesses per capita. Based on the previous empirical studies, the determinants were selected and hypothesis stated. Formed hypothesis investigated positive impact of GDP per capita, unemployment rate and R&D institutions on rate of registered business activity. To evaluate them, data were obtained from the Czech Statistical Office and formed into dataset. Firstly, panel regressions estimated with fixed effects method were employed and secondly, Granger causality tests to evaluate the relationship between entrepreneurial activity and GDP per capita were used. Regression estimates proved positive relationship between entrepreneurial activity in Czech regions and GDP per capita, unemployment rate and support activities of R&D institutions. Positive impact was also confirmed for population density, average age, share of tertiary educated population and real R&D expenditures. Testing Granger causality proved dual causality between entrepreneurial activity and GDP per capita confirming that GDP per capita as good predictor of economic development of Czech regions. Finally, economic growth motivates Czech individuals to enter entrepreneurial activity.

  9. CzechGeo/EPOS - Building a national data portal

    Science.gov (United States)

    Zednik, J.; Hejda, P.

    2012-04-01

    CzechGeo/EPOS is the consortium of seven geoscience institutions in the Czech Republic (Institute of Geophysics AS CR Prague, Institute of Rock Structure and Mechanics AS CR Prague, Institute of Geonics AS CR Ostrava, Institute of Physics of the Earth, Masaryk University Brno, Faculty of Mathematics and Physics, Charles University Prague, Faculty of Science, Charles University Prague, and Research Institute of Geodesy, Cartography and Topography Zdiby). These institutions operate a distributed system of seismic, GPS, magnetic, gravimetric and geodynamic observatories. The operational and personal costs of CzechGeo/EPOS are mostly covered by the Ministry of education, sports and youth within the support of twelve large research infrastructures in the Czech Republic. Web pages of the project www.czechgeo.cz are being built as a data portal which should integrate all the data and services provided by the involved institutions and research infrastructures. Seismic portal offers selected portions of digital data from permanent, local and temporary seismic stations, locations of seismic events in the country and worldwide, daily seismograms from permanent observatories and local seismic network Webnet, seismic bulletins and catalogs, and macroseismic observations on the territory of the Czech Republic. Magnetic portal involves besides real-time magnetograms also recent state of geomagnetic activity and its forecast for the next day. GPS portal will provide preprocessed data from regional GPS stations. Building the national portal is closely related with the development of the Preparatory phase of the EPOS (European Plate Observing System) project.

  10. Key Sustainability Performance Indicator Analysis for Czech Breweries

    Directory of Open Access Journals (Sweden)

    Edward Kasem

    2015-01-01

    Full Text Available Sustainability performance can be said to be an ability of an organization to remain productive over time and hold on to its potential for maintaining long-term profitability. Since the brewery sector is one of the most important and leading markets in the foodstuff industry of the Czech Republic, this study depicts the Czech breweries’ formal entry into sustainability reporting and performance. The purpose of this paper is to provide an efficiency level evaluation which would represent the level of corporate performance of Czech breweries. For this reason, Data Envelopment Analysis (DEA is introduced. In order to apply it, we utilize a set of key performance indicators (KPIs based on two international standard frameworks: the Global Reporting Initiative (GRI and its GRI 4 guidelines, and the guideline KPIs for ESG 3.0, which was published by the DVFA Society. Four sustainability dimensions (economic, environmental, social and governance are covered, making it thus possible to adequately evaluate sustainability performance in Czech breweries. The main output is not only the efficiency score of the company but also the input weights. These weights are used to determine the contribution of particular criteria to the breweries’ achieved score. According to the achieved efficiency results for Czech breweries, the percentage of women supervising the company does not affect the sustainability performance.

  11. Doing Business in Czech Republic after Accession to the EU

    Directory of Open Access Journals (Sweden)

    Dusan Litva

    2017-11-01

    Full Text Available Purpose of the article: European Union can be considered as a full integration process including political, safety, social or economic aspects. Economic integration is process of interconnection otherwise separated national markets (by removal of economic borders. This assumes removal of all obstacles (in economy, trade, tax, administration or industrial area and establishment of common rules for market competition. Basic benefit of economic integration is occurrences of real or potential competitiveness effects. Methodology/methods: European integration influenced number of factors of business environment mainly in area of legislation, taxes, public competition or harmonization of norms which can result in overall Czech Republic competitiveness abroad. In these papers have been used DB and GCI indexes and their subsequent indicators to analyze competitiveness and business environment in CR. Scientific aim: The aim of this article is research on impact of European integration on business environment and competitiveness of Czech Republic. Findings: Growing DTF trend for DB index since 2004 shows improvement of business environment after accession to the EU in contrast with non- EU members (Switzerland, Norway which remains flat. The biggest benefit for Czech business environment seems to be trade liberalization as Czech companies were able to compete successfully at foreign markets. On the other hand, according to GCI remains biggest challenge non- effective bureaucracy, tax regulation, corruption, political instability and low business sophistication. Conclusions: Czech Republic should focus, consistently with Lisbon strategy, on qualification of labour forces, increase o

  12. Relationship of reverse logistics and marketing communication in Czech Republic

    Directory of Open Access Journals (Sweden)

    František Milichovský

    2016-09-01

    Full Text Available Purpose of the article: The paper deals with question if the final customers are interested in reverse logistics in marketing campaigns, acceptable in the market of Czech Republic. methodology/methods: Paper is based on primary research, on which participated final consumers in Czech Republic through the questionnaire survey. Results of the paper are based on testing of dependence between individual variables by Pearson chi-square test. Scientific aim: The aim of the article is to show relationship of marketing communication and reverse logistics, and their correlation. Findings: Main result of research provide relationship between marketing communication tools and reverse activity. The research was aimed at random chosen group of 585 people in the Czech Republic. The result of the research can be used for the companies that operate in the Czech or Central European market. conclusions: The primary research provides possible approaches for companies in communication green services to final consumers. Limitation for this research because of the chosen sample. Own data for primary research was gained only in Czech Republic.

  13. Selected Views on Fixed Assets in the Czech Economy

    Directory of Open Access Journals (Sweden)

    Drahomíra Dubská

    2011-03-01

    Full Text Available Gross fixed capital formation (investment in the Czech economy has been remaining the significant component of gross domestic product (GDP from expenditure side during last roughly decade – in spite of the modest decrease in its share in GDP in nominal terms (from less than one third in 1995 to just about one quarter in 2008. In real terms its share in the GDP shows more likely stagnation (from 29% in 1995 to 28% in 2008. But correlation between GDP and investment in the Czech Republic is weaker compared to EU27. The increases of the various types of fixed assets in the Czech economy in constant prices of the year 2000 show clearly more dynamic growth in machinery and equipment in comparison with the dwellings and other buildings and structures. NACE K Real estate, renting and business activities participated most in the total state quantity of the gross capital formation. Although the state of the gross fixed capital formation was growing on average by about 2%, y-o-y, the investment in dwellings in constant prices of the year 2000 only stagnated. Thearticle describes the reasons for that. The tangible assets in the households sector are mentioned, as well. The last part analyses current problems of investment in the Czech economy during economic crisis of 2009. Nevertheless, the fall of gross fixed capital formation in that year should not influence negatively the convergence of the Czech economy towards EU27 level.

  14. Boarding the Euro Plane : Euro Adoption in the Czech Republic and Slovakia

    NARCIS (Netherlands)

    Dandashly, Assem; Verdun, Amy

    2015-01-01

    What explains euro adoption strategies in the Czech Republic and Slovakia? How have each of these two countries performed under the regime they joined (Czech Republic: flexible exchange rates; Slovakia: in the euro area)? How has that experience affected Czech and Slovak policies towards euro

  15. [Lenalidomid (Revlimid) in the treatment of multiple myeloma--first experience in the Czech Republic].

    Science.gov (United States)

    Novotová, E; Neuwirtová, R; Jonásová, A; Straub, J; Spicka, I

    2008-01-01

    The prognosis of multiple myeloma (MM) has substantially improved during last decades due to new, so-called targeted drugs--proteasome inhibitor bortezomib and immunomodulatory drugs (ImiDs), thalidomide and lenalidomide. They could be used in various combinations and/or sequentially thanks to different mechanism of action and toxicity. Both bortezomib and thalidomide are widely used in Czech republic, however, lenalidomide was approved for the treatment of MM (and MDS) at the very latest and its usage is limited due to high costs, as well. According to the results of clinical trials lenalidomide is effective in myeloma refractory to various therapy including other new drugs. First time in the Czech republic the combination of lenalidomide and dexamethasone was given in our center to 2 patients with relapsed myeloma as 7th and 10th line of therapy. Acceptable results of treatment with improved clinical status in the first patient enabled to suspend his therapeutic plasmaferesis. Disease stabilization lasting three months was observed also in the second patient.

  16. Clinical, endoscopic, and pathologic characteristics of colorectal polyps in Indian children and adolescents.

    Science.gov (United States)

    Rathi, Chetan; Ingle, Meghraj; Pandav, Nilesh; Pipaliya, Nirav; Choksi, Dhaval; Sawant, Prabha

    2015-11-01

    Colorectal polyps are among the common causes for rectal bleeding in children. We studied the clinical, colonoscopic, and histopathological features of colorectal polyps and polyposis syndrome in Indian children and adolescents. Medical records of children and adolescents with colorectal polyps and polyposis syndrome were retrospectively reviewed from 2001 to 2014 at Department of Gastroenterology, in large tertiary care center of Mumbai. A total of 120 patients were found to have colonic polyps during study period. Mean age of presentation in children was 7.31 ± 4.05 years (range 2 to 19 years), with male-to-female ratio of 2.16:1. Rectal bleeding was presenting symptom in 95.8 % with mean duration of 12.6 ± 15 months. Majority of polyps (77.5 %) were juvenile, and 97.2 % were located in left colon. Solitary polyps were seen in 76.6 %, multiple polyps in 11.6 %, juvenile polyposis syndrome in 6.6 %, familial adenomatous polyposis in 4.2 %, and Peutz-Jeghers syndrome in 0.8 % of the children. The polyposis syndrome group had higher age at presentation (p = 0.00006), greater likelihood of anemia, abdominal pain, and diarrhea (p = 0.0001, 0.0002, and 0.0051, respectively). Likelihood of adenomatous change in polyps was higher in polyposis syndrome group (p = 0.0003). Left colonic polyps were more common in non-polyposis group, whereas pan-colonic polyps were more common in polyposis syndrome group (p < 0.00001). Presence of anemia, abdominal pain, diarrhea, higher age at presentation (more than 10 years), and history of polypectomy are clinical indicators of polyposis syndrome.

  17. Intraday and intraweek trade anomalies on the Czech stock market

    Directory of Open Access Journals (Sweden)

    Oleg Deev

    2012-01-01

    Full Text Available The paper examines intraday and intraweek market returns on the Czech stock market for the search of time and seasonal anomalies in its activities during the last ten years. Existence or absence of anomalies indicates the efficiency of the market. A group of regression models and GARCH (1,1 model is used for the analysis of daily and high frequency data of the PX index. Time varying nature of market seasonalities is revealed with the Czech equity market having implications for changing efficiency over the studied period, when the Czech Republic’s accession to the EU implied the increase in efficiency and the global financial crisis led to opposite results and regularities, which are not yet fully overcomed. Additionally, significant hour-of-the-day effect (open jump effect in the index returns is established.

  18. Migration Behaviour of Strontium in Czech Bentonite Clay

    Directory of Open Access Journals (Sweden)

    Lucie Baborova

    2016-09-01

    Full Text Available The study deals with sorption and diffusion behaviour of strontium in Czech bentonite B75. The study is a part of a research on reactive transport of radioactive contaminants in barrier materials of a deep geological repository of radioactive waste in the Czech Republic. Series of sorption and diffusion experiments with Sr and non-activated Ca bentonite B75 produced in the Czech Republic were performed in two background solutions (CaCl2 and NaCl. On the basis of sorption batch experiments the kinetics of strontium sorption on bentonite was assessed and the sorption isotherms for various experimental conditions were obtained. As a result of performed diffusion experiments the parameters of diffusion (i.e. effective diffusion coefficient De and apparent diffusion coefficient Da were determined. The observed discrepancies between sorption characteristics obtained from the sorption and diffusion experiments are discussed.

  19. Threat Prioritization Process for the Czech Security Strategy Making

    Directory of Open Access Journals (Sweden)

    Milos Balaban

    2012-06-01

    Full Text Available This article offers systematic view of a process of identification of security threats and, subsequently, their use in the making of strategic documents, notably the Security Strategy of the Czech Republic. It is not the aim of the authors to name or define such threats, but to present the process itself. It is paramount to any credible security strategy that it deals with the threat identification in the most precise fashion. The authors take reservations against the “catalogue” approach and claim the processes of prioritization and categorization to be essential for any policies derived from the security strategy, especially in times of economic need. It is also the 2011 final paper of the project “Trends, Risks, and Scenarios of the Security Developments in the World, Europe, and the Czech Republic – Impacts on the Policy and Security System of the Czech Republic” (TRS / VG20102013009.

  20. Religion, Culture, and Tax Evasion: Evidence from the Czech Republic

    Directory of Open Access Journals (Sweden)

    Wadim Strielkowski

    2015-06-01

    Full Text Available Our paper analyzes the impact of culture and religion on tax evasions in the Czech Republic, which represents one of the most atheistic countries in Europe, and a very interesting example of attitudes to the church and religion, as well as the influence of religion on the social and economic aspects of everyday life. Our results suggest that, in the Czech Republic, religion plays the role of tax compliance, but only through a positive effect of visiting the church. National pride supports tax morality while trust in government institutions and attitudes towards government are not associated with tax compliance. These results suggest that the Czech Republic is no different from other countries regarding the relationship between religion and tax compliance. Moreover, the role of government as the authority for improving tax compliance is different from what is observed in other countries.

  1. BIGGEST CZECH BANKS IN THE MIRROR OF ANNUAL REPORTS

    Directory of Open Access Journals (Sweden)

    Vladislav PAVLAT

    2016-02-01

    Full Text Available The aim of the Paper is to characterise and analyse the biggest Czech banks Annual reports (ARs. Since 2004, the behaviour of Czech banks has been changing, as can be seen – inter alia - from the big banks´ financial statements and annual reports. During the period of 2007 – 2013 the implementation of IFRS continued and its impact on the institutional structure of banking is visible. From the point of view of banks, annual reports present not only the financial results, but they serve as an important instrument of competition and marketing as well. Comparative analysis of the three Czech leading banks gives a picture of their specific features as reflected in their annual statements.

  2. Exile, Return and Restitution in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Katharine A Vadura

    2005-03-01

    Full Text Available The exile and return experiences in the Czech lands since 1918 have been various and have had significant implications for the people who live and once lived in that territory. The focus of this paper is on the Sudeten Germans a former minority of the Czech lands. The exile experience of this group has resulted in significant debate as to whether this form of exile as legislated banishment was expulsion or displacement, and whether they should have the right to return. In addition the question of guilt as a mechanism for invoking the forced transfer of a population has also raised the issue of recompense or restitution. Conceptual issues like nationalism, identity, belonging and the right to a homeland have played an important part in the attempts at the development of a stable state and also more recently reconciliation processes between the Czechs and Sudeten Germans.

  3. Production and Logistics Performance of Czech and Slovak Companies

    Directory of Open Access Journals (Sweden)

    Polakova Veronika

    2013-03-01

    Full Text Available This contribution deals with the issues of production and logistics performance of Czech and Slovak companies. The goal of the research was to analyze logistic processes, methods of industrial engineering, methods and evaluation of manufacturing, software tools utilized for measurement and management of performance, which are currently applied in manufacturing companies in the Czech and Slovak Republic. This analysis was done with the utilization of qualitativeresearch conducted in 80 selected manufacturing companies in 2009. The results are compared in the continuity with the conclusions from previous researches on manufacturing and logistic factors of the competitiveness of Czech industrial manufacturers carried out during the period 2000-2001 in the framework of the research project of the Faculty of Economics and Management completed in 2004.

  4. Determinants of the Profitability in the Czech Banking Industry

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    Iveta Palečková

    2016-12-01

    Full Text Available The aim of this paper is to estimate the banking profitability determinants of the Czech commercial banks during the period 2004-2014. For estimation of banking profitability we used three common measures, namely the Return on Assets, Return on Equity and Net Interest Margin. We estimated twelve determinants of banking performance. The effect of the determinants of banking profitability is estimated using panel data analysis. The data set is consists of seventeen commercial banks in the Czech Republic. The results show that the profitability was positively influenced by the bank’s size, capitalization, credit risk, level of concentration, ownership structure and bank’s market share. Number of branches of the bank had the negative impact on ROA and ROE. on the other hand, the variables Gross Domestic Product, interest rate, liquidity risk, riskiness of bank’s portfolio and affiliation with financial conglomerate have not got the significant influence on profitability of the Czech commercial banks.

  5. The presentation of senior citizens in Czech media

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    Molinova A.

    2014-01-01

    Full Text Available Czech media do not participate on formation of the intergenerational solidarity and understanding but they might be one of the causes of intergenerational gap in the Czech Republic. Young people do not have a chance to learn anything about the positive sides in seniors’ lives through the media. As Papežová says (2010, p. 57 if people get themselves acquainted with the process of aging in their youth it might help them to remove their concerns about this stage of life. In the future we should try to promote the positive portrait of seniors in Czech media and the mediation of communication between seniors and the young generation. If the media give more space to the topics concerning seniors and picture these in more positive manner, it is one of the ways how to fight with still growing intergenerational gap.

  6. Training of academic writing: improving competitiveness of Czech universities

    Directory of Open Access Journals (Sweden)

    Tomáš Foltýnek

    2013-01-01

    Full Text Available Project “Impact of Policies for Plagiarism in Higher Education across Europe” has reached its final phase. We have collected lots of data reflecting facts and opinions about plagiarism and related areas. Training of academic writing is one of important means for plagiarism prevention.The paper compares levels of training of academic writing between the Czech republic and the rest of Europe. The answers in a questionnaire survey dealing with plagiarism and training of academic writing will be compared and analysed. According to these answers, best practices in European higher education institutions will be identified, and gaps in the Czech institutions will be described. Removing gaps than poses a step to improve the competitiveness of the Czech higher education institutions.

  7. Local energy policies in Poland and the Czech Republic

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    Both the Czech Republic and Poland as former Communist countries, are transforming their economies from central planning to a free market. This applies equally to energy planning and because they are starting from the same point, they have come up with very comparable solutions despite strong cultural differences, so that the parallels are striking. This study analyzes the energy management in local authorities in Poland and the Czech Republic with the objective of better: identifying the current situation, identifying the opportunities for action both now and in an extended European Union, identifying the constraints that may hinder full integration of East European municipalities in European Union programmes, improve the integration of municipalities in the countries concerned in pan-European networks of municipalities interested in energy issues. The study reviews the powers and responsibilities of local authorities in the energy field and the institutional framework within which local authorities work. There are now 16 directly elected regional authorities in Poland and the local authorities have been restructured into two levels, the Powiad and the Gmina. Similarly, in the Czech Republic 14 elected regional authorities have been established. This document brings together 2 reports: the final report and the study report about the energy policies in Poland and in the Czech republic: structure of local government, general and institutional aspects, national political organisation, national administrative organisation, municipal role in production and distribution, regulation and planning, energy issues, energy management policies, specific aspects at local level etc... The conclusions from two review seminars (Jablonec nad Nison (Czech republic), 25-26 January 2001, and Bielsko Biala (Poland), 22-23 February 2001) and some fact files on 4 large Czech towns and 4 large Polish towns complete the study. (J.S.)

  8. Early stages of pediatric bipolar disorder: retrospective analysis of a Czech inpatient sample

    Directory of Open Access Journals (Sweden)

    Goetz M

    2015-11-01

    Full Text Available Michal Goetz,1 Tomas Novak,2 Marie Vesela,1 Zdenek Hlavka,3 Martin Brunovsky,2 Michal Povazan,4 Radek Ptacek,5 Antonin Sebela21Department of Child Psychiatry, Second Faculty of Medicine, Motol University Hospital, Charles University in Prague, Prague, Czech Republic; 2National Institute of Mental Health, Klecany and Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; 3Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University in Prague, Prague, Czech Republic; 4Children’s Department, Bohnice Psychiatric Hospital, Prague, Czech Republic; 5Department of Psychiatry, First Faculty of Medicine, General Teaching Hospital, Charles University in Prague, Czech RepublicBackground: Approximately 30%–60% of adults diagnosed with bipolar disorder (BD report onset between the ages 15 and 19 years; however, a correct diagnosis is often delayed by several years. Therefore, investigations of the early features of BD are important for adequately understanding the prodromal stages of the illness.Methods: A complete review of the medical records of 46 children and adolescents who were hospitalized for BD at two psychiatric teaching centers in Prague, Czech Republic was performed. Frequency of BD in all inpatients, age of symptom onset, phenomenology of mood episodes, lifetime psychiatric comorbidity, differences between very-early-onset (<13 years of age and early-onset patients (13–18 years, and differences between the offspring of parents with and without BD were analyzed.Results: The sample represents 0.83% of the total number of inpatients (n=5,483 admitted during the study period at both centers. BD often started with depression (56%, followed by hypomania (24% and mixed episodes (20%. The average age during the first mood episode was 14.9 years (14.6 years for depression and 15.6 years for hypomania. Seven children (15% experienced their first mood episode before age 13

  9. PRODUCTIVITY AND EFFICIENCY DIFFERENCES BETWEEN CZECH AND SLOVAK MILK PRODUCERS

    Directory of Open Access Journals (Sweden)

    Lukas CECHURA

    2014-11-01

    Full Text Available The paper deals with the analysis of productivity and efficiency differences between Czech and Slovak milk producers. The estimate of stochastic metafrontier multiple output distance function revealed that both Czech and Slovak milk producers highly exploit their production possibilities. On the other hand, productivity differences were pronounced. The Slovak regions were found being falling behind. Only the West Slovak regions can keep pace with competitors. The Central Bohemia and Moravian-Silesian regions are the most productive regions. We found that technical efficiency and management component are the most important factors determining the regional differences.

  10. Change in Wage Inequality in the Czech Republic

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Pytlikova, Mariola; Warzynski, Frederic

    investigate various hypotheses related to transition towards a market economy, increased domestic and international competition and an increasingly decentralized wage bargaining to explain these patterns. We find some support for that the three mechanisms - increased international competition, further......In this paper, we look at the evolution of the Czech labor market, and its wage structure in particular, using a linked employer-employee dataset covering a large fraction of the Czech labor market over the period 1998-2006. Estimating conventional earnings equations we find evidence of diminishing...

  11. Alternatives sources of energy in the Czech energy mix

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Lisy; Marek, Balas; Zdenek, Skala

    2010-09-15

    The paper features a basic outline of the situation in the energy sector of the Czech Republic. It brings information about the current state of the country's energy mix and indicative targets of the State Energy Policy. Though coal and nuclear energy will remain the country's energy staples, great stress is also put on the growth of share of renewable and alternative energy sources. Out of these, the greatest potential in the Czech Republic is that of biomass and waste. To make the use of these sources cost-effective, it is necessary to put stress on heat and power cogeneration.

  12. Change in Wage Inequality in the Czech Republic

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Pytlikova, Mariola; Warzynski, Frederic

      In this paper, we look at the evolution of the change in the wage structure using a linked employer-employee dataset covering a large fraction of the Czech labor market over the period 1998-2006. We find evidence of slightly diminishing gender inequality and increasing returns to human capital...... decentralized wage bargaining and a changing educational composition of the workforce to explain these patterns. We find some support that these factors have contributed to the changes in the Czech wage structure, although the latter is the most strongly associated with the observed changes in wage inequality....

  13. Changes in Wage Inequality in the Czech republic

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Pytlikova, Mariola; Warzynski, Frederic

    In this paper, we look at the evolution of the change in the wage structure using a linked employer-employee dataset covering a large fraction of the Czech labor market over the period 1998-2006. We find evidence of slightly diminishing gender inequality and increasing returns to human capital...... decentralized wage bargaining and a changing educational composition of the workforce to explain these patterns. We find some support that these factors have contributed to the changes in the Czech wage structure, although the latter is the most strongly associated with the observed changes in wage inequality...

  14. Environmental Impact Assessment of Wind Generators in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Vladimír Lapčík

    2008-11-01

    Full Text Available The article summarizes author´s experience with environmental impact assessment in branch of wind generators. The introductorypart of paper describes legislative obligations of the Czech Republic in frame of fulfilling the European Union´s limits in branch ofrenewable energy resources utilization. Next part of paper deals with analysis of impacts of wind generators on the environment.The final part of paper deals with experience with implementation of the environmental impact assessment process (pursuant to the ActNo. 100/2001 Coll. in the field of wind power in the Czech Republic.

  15. The Czech Tea Profession and the Phenomenon of Tea Rooms

    OpenAIRE

    Schröderová, Karolína

    2015-01-01

    In this bachelor thesis I have focused on the Czech tea culture and tea profession across tea rooms. I have dealt with influences that led to the present tea rooms' appearances. Furthermore I am dealing with ways of tea culture spreading, and what conduces to the tea room establishing. I am using the term of subculture in the connection with the tea culture, its meaning and position in the Czech culture. The main data source were semi- structured interviews with the tea rooms owners, all comp...

  16. The experience of loneliness of Canadian and Czech youth.

    Science.gov (United States)

    Rokach, Ami; Bauer, Natasha; Orzeck, Tricia

    2003-06-01

    The present study examined the influence of cultural background on adolescents' experience of loneliness. Eighty Canadians and 168 adolescents from the Czech Republic formed the participants pool. They answered a 30-item yes/no questionnaire. The questionnaire is composed of five subscales, namely: Emotional distress, Social inadequacy and alienation, Growth and discovery, Interpersonal isolation, and Self-alienation. Results revealed a mixed pattern of differences between the two cultures, with Canadian youth scoring higher than the Czechs only on Emotional distress, while that trend was reversed in Social inadequacy and alienation and Interpersonal isolation. Gender differences within cultures were also examined.

  17. Closed detention in the Czech Republic: on what grounds?

    Directory of Open Access Journals (Sweden)

    Beáta Szakácsová

    2013-09-01

    Full Text Available People who arrive by air in the Czech Republic claiming asylum are transferred to a ‘reception centre’ at Prague’s Vaclav Havel Airport. Although they are deprived of their liberty, have limited access to fresh air and to the internet, and are only allowed to use a payphone, asylum seekers at the centre are not treated as criminals and detainees report that conditions in the reception centre are moderately good. However, there are some significant problems in the Czech Republic’s current practice of detaining applicants for international protection.

  18. Coccidiosis in goats in the Czech Republic.

    Science.gov (United States)

    Koudela, B; Boková, A

    1998-04-30

    An observational study was conducted to determine coccidial infections in goats of 13 farms in the Czech Republic. The prevalence of oocysts of Eimeria species in kids (less than 3 months old), weaned but not served goats (from 3 months to 1 year), and adult goats (1 year or more) was determined. Nine Eimeria species were identified in fecal samples by Sheather's sugar flotation technique. The overall prevalence of Eimeria oocysts in fecal specimens was 92.2%. Eimeria arloingi was the most common species with an overall prevalence of 84%, followed by E. hirci (63%) and E. ninakohlyakimovae (56%). Other species present were E. christenseni (55%), E. alijevi (36%), E. caprina (25%), E. aspheronica (12%), E. capriovina (6%) and E. jolchijevi (2%). Two or more Eimeria species were detected in 88% of the samples. The most prevalent species in kids was E. arloingi, while in weaned but not served and adult goats E. ninakohlyakimovae was the most frequently found. The number of oocysts excreted was generally lower in adult goats (2567.3+/-12678 OPG), whereas higher number oocyst per gram of feces (OPG) were found in kids (18565+/-24888 OPG). Clinical coccidiosis was detected in two farms, and E. arloingi and E. ninakohlyakimovae were implicated as its cause. Disease was observed in kids 2 to 4 weeks after weaning and watery feces with clumps of mucus, and color changes from brown to yellow or dark tarry, weight loss, and dehydration were the most conspicuous clinical signs. At necropsy, macroscopic changes included mucosal hemorrhages and whitish nodular polyps in the jejunum were found. Histopathological changes were characterized by local hypertrophy and hyperplasia of intestinal villi, villus blunting and inflammatory infiltration in the lamina propria. Numerous developmental stages of the parasites were observed in enterocytes and lacteals of intestinal villi.

  19. Transformation of the Czech refinery and petrochemical

    International Nuclear Information System (INIS)

    Junek, V.

    1995-01-01

    The petrochemical and chemical industries in former Czechoslovakia in the period after World War II was built up with a purpose to create a complex whose individual subjects would be closely interlinked from the point of view of their production programmes. The separation of Slovakia as an independent state has disrupted some of these links. In spite of that the petrochemical and chemical industries are nowadays the most prosperous branches of economy of the Czech Republic. The governmental proposal for the reorganizing of the refinery and petrochemical complex elaborated in connection with the resolution of the Governmental Privatization Commission of November 6 1994 proposed the formation of a holding company Unipetrol in the way of merging Chemopetrol and Kaucuk with a new joint stock company Unipetrol established for this purpose by the National Property Fund. The updated proposal offers formation of the holding organization Unipetrol in a substantially simpler, from the point of view of time, organization and financing less demanding manner. This proposal is based on the following principles: respecting the approved privatization projects, the solution must not have influence on the rights and position of natural and juristic persons who became shareholders in accordance with the privatization projects already approved, the influence of the state on decisions of the holding and its daughter companies will be maintained with regard to the security of the state and supplying the strategically important subjects with fuels in situation of a crisis, the share of the business subjects in the shares of the holding will be such that it would enable them from the very beginning to participate effectively and not only formally in the decisions. 2 figs

  20. Variation in the vitamin D receptor gene is not associated with risk of colorectal cancer in the Czech Republic.

    LENUS (Irish Health Repository)

    Hughes, David J

    2012-02-01

    PURPOSE: Increased levels of vitamin D may protect against colorectal cancer (CRC) development and recurrence. Accumulating epidemiologic evidence suggests these effects may be partly mediated by genetic variants of the vitamin D receptor (VDR) proposed to be associated with altered risk of CRC. We wished to determine if common VDR polymorphisms affected CRC risk in the Czech Republic, a homogenous European population with a high CRC incidence rate. METHODS: Frequencies of the common VDR gene polymorphisms rs2238136, rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case control analysis of a series of 754 CRC patients and 627 patients without malignant disease recruited from centers throughout the Czech Republic. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between these variants and risk of CRC. RESULTS: None of the four polymorphisms tested had any significant effect on CRC risk. No significant differences were observed in susceptibility when the population was stratified by anatomical sub-site, sex, BMI, smoking, alcohol, or presence of polyps. CONCLUSIONS: We conclude that common variation in the VDR gene had little effect on its own on predisposition to sporadic CRC in the Czech population.

  1. Risk management in inpatient units in the Czech Republic from the point of view of nurses in leadership positions.

    Science.gov (United States)

    Prokešová, Radka; Brabcová, Iva; Pokojová, Radka; Bártlová, Sylva

    2016-12-01

    The goal of this study was to assess specific features of risk management from the point of view of nurses in leadership positions in inpatient units in Czech hospitals. The study was performed using a quantitative research strategy, i.e., a questionnaire. The data sample was analyzed using SPSS v. 23.0. Pearson's chi-square and analysis of adjusted residues were used for identifying the existence associations of nominal and/or ordinal quantities. 315 nurses in leadership positions working in inpatient units of Czech hospitals were included in the sample. The sample was created using random selection by means of quotas. Based on the study results, statistically significant relations between the respondents' education and the utilization of methods to identify risks were identified. Furthermore, statistically significant relationships were found between a nurse's functional role within the system and regular analysis and evaluation of risks and between the type of the healthcare facility and the degree of patient involvement in risk management. The study found statistically significant correlations that can be used to increase the effectiveness of risk management in inpatient units of Czech hospitals. From this perspective, the fact that patient involvement in risk management was only reported by 37.8% of respondents seems to be the most notable problem.

  2. Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population.

    Science.gov (United States)

    Hlousková, Alena; Bonczek, Ondrej; Izakovicová-Hollá, Lydie; Lochman, Jan; Soukalová, Jana; Stembírek, Jan; Mísek, Ivan; Cernochová, Pavlína; Krejcí, Premysl; Vanek, Jirí; Šerý, Omar

    2015-01-01

    Tooth agenesis is one of the most common developmental anomalies in humans. Genetic and environmental factors may be of etiological importance in this condition. Among genes involved in tooth morphogenesis, mutations in PAX9, MSX1, AXIN2, WNT10a, and EDA genes have been associated with tooth agenesis. The aim of our study was to investigate the relationship between the PAX9 gene variants and tooth agenesis in the Czech population. The selected regions of the PAX9 gene were analysed by direct sequencing and compared with the reference sequence from the GenBank online database (NCBI). We found several novel variants in the PAX9 gene, e.g. insertion g.5100_5101insC (rs11373281) with simultaneous substitution g.5272C>G (rs4904155) in exon 1, and mutation g.10934C>T (Gly203Gly, rs61754301) in exon 3. In subjects with full dentition we observed polymorphisms g.10276A>G (rs12882923) and g.10289A>G (rs12883049) in IVS2 (intervening sequence 2) previously related to tooth agenesis in Polish study. In our study we excluded a direct effect of rs12882923 and rs12883049 polymorphisms on the dental agenesis in the Czech population. All described PAX9 genetic variants were present both in patients with tooth agenesis and controls. We expect that tooth agenesis in our cohort of patients is caused by mutations in regions different from PAX9 exons analyzed in our study.

  3. [The origins of the Czech Society of Cardiology and of Czech cardiology].

    Science.gov (United States)

    Widimský, J

    2013-06-01

    The paper presents the origins of the Czech Society of Cardiology on the one hand, and the origins of Czech cardiology on the other. The Czech Society of Cardiology is the third oldest in the world (after the American and German Societies). It was founded in 1929 by Prof. Libenský. As early as in 1933, the Society organised the first international congress of cardiologists in Prague, which was attended by 200 doctors, out of which 50 were from abroad. The most participants came from France and Poland. Other participants came from England, Argentina, Belgium, the Netherlands, Italy, Romania, Spain and Switzerland. The worldwide importance of this congress is apparent from the fact that both the World Society of Cardiology and the European Society of Cardiology (EKS) were founded after World War II in the years 1950 and 1952, i.e. almost 20 years after the first international congress of cardiology in Prague. In 1964, the Fourth Congress of European Society of Cardiology was held in Prague with the participation of 1,500 specialists from 31 countries and chaired by Prof. Pavel Lukl, the later president of EKS (1964- 1968). The paper also presents the work of our specialists in WHO and the history of the international journal Cor et Vasa issued by the Avicenum publishing house in Prague in English and Russian in the years 1958- 1992. An important role in the development of our cardiology was played by certain departments and clinics. In 1951, the Institute for Cardiovascular Research (ÚCHOK) was founded in PrahaKrč, thanks to the initiative of MU Dr. František Kriegl, the Deputy Minister of Health. Its first director was Klement Weber, who published, as early as in 1929, a monograph on arrhythmias -  50 years earlier than arrhythmias started to be at the centre of attention of cardiologists. Klement Weber was one of the doctors of President T. G. Masaryk during his serious disease towards the end of his life. Jan Brod was the deputy of Klement Weber in the

  4. Image značky Českého Olympijského týmu - Czech Team

    OpenAIRE

    Čmucha, Jiří

    2011-01-01

    Title: Brand Image Of The Czech Olympic Team - CZECH TEAM Objectives: A main objective of bachelor thesis is creationing of a complex description of the brand image of the Czech Olympic Team - Czech Team. To achieve defined objective was necessary to determinate a profile of the brand, its origin, progress, functions, reasons or sense of the brand existence and brand identity. At the same time a quantitative research was executed finding out knowledge and awareness of the brand Czech Team amo...

  5. Novel APC mutations in Czech and Slovak FAP families: clinical and genetic aspects

    Directory of Open Access Journals (Sweden)

    Vesela Kamila

    2007-04-01

    Full Text Available Abstract Background Germline mutations in the adenomatous polyposis gene (APC result in familial adenomatous polyposis (FAP. FAP is an autosomal dominantly inherited disorder predisposing to colorectal cancer. Typical FAP is characterized by hundreds to thousands of colorectal adenomatous polyps and by several extracolonic manifestations. An attenuated form of polyposis (AFAP is characterized by less than 100 adenomas and later onset of the disease. Methods Here, we analyzed the APC gene for germline mutations in 59 Czech and 15 Slovak FAP patients. In addition, 50 apparently APC mutation negative Czech probands and 3 probands of Slovak origin were screened for large deletions encompassing the APC gene. Mutation screening was performed using denaturing gradient gel electrophoresis and/or protein truncation test. DNA fragments showing an aberrant electrophoretic banding pattern were sequenced. Screening for large deletions was performed by multiplex ligation dependent probe amplification. The extent of deletions was analyzed using following microsatellite markers: D5S299, D5S82, D5S134 and D5S346. Results In the set of Czech and Slovak patients, we identified 46 germline mutations among 74 unrelated probands. Total mutation capture is 62,2% including large deletions. Thirty seven mutations were detected in 49 patients presenting a classical FAP phenotype (75,5% and 9 mutations in 25 patients with attenuated FAP (36%. We report 20 novel germline APC mutations and 3 large deletions (6% encompassing the whole-gene deletions and/or exon 14 deletion. In the patients with novel mutations, correlations of the mutation localization are discussed in context of the classical and/or attenuated phenotype of the disease. Conclusion The results of the molecular genetic testing are used both in the establishment of the predictive diagnosis and in the clinical management of patients. In some cases this study has also shown the difficulty to classify clinically

  6. Oral pigmentation induced by Premarin.

    Science.gov (United States)

    Pérusse, R; Morency, R

    1991-07-01

    Pigmented lesions of the oral cavity are important entities. The wide range of their clinical differential diagnosis includes such diverse systemic conditions as Addison's disease, Peutz-Jeghers syndrome, malignant melanoma, Kaposi's sarcoma, as well as specific oral lesions, such as amalgam tattoo or gingival melanosis. This paper reports a very rare cause of oral pigmentation, a melanic type, related to the use of Premarin.

  7. Case report

    African Journals Online (AJOL)

    Raoul

    27 mars 2012 ... Cell Mol Life Sci. 2006 Sep;63(18):2135-44. This article on PubMed. 5. Mehenni H, Gehrig C, Nezu J, Oku A et al. Loss of LKB1 Kinase Activity in Peutz-Jeghers Syndrome, and Evidence for Allelic and Locus. Heterogeneity. Am J Hum Genet. 1998 Dec;63(6):1641-50. This article on PubMed. 6. Mehenni H ...

  8. Ice Hockey Lung – A Case of Mass Nitrogen Dioxide Poisoning in The Czech Republic

    Directory of Open Access Journals (Sweden)

    Kristian Brat

    2013-01-01

    Full Text Available Nitrogen dioxide (NO2 is a toxic gas, a product of combustion in malfunctioning ice-resurfacing machines. NO2 poisoning is rare but potentially lethal. The authors report a case of mass NO2 poisoning involving 15 amateur ice hockey players in the Czech Republic. All players were treated in the Department of Respiratory Diseases at Brno University Hospital in November 2010 – three as inpatients because they developed pneumonitis. All patients were followed-up until November 2011. Complete recovery in all but one patient was achieved by December 2010. None of the 15 patients developed asthma-like disease or chronic cough. Corticosteroids appeared to be useful in treatment. Electric-powered ice-resurfacing machines are preferable in indoor ice skating arenas.

  9. Well-being in a Czech population sample

    Czech Academy of Sciences Publication Activity Database

    Kebza, V.; Kodl, M.; Šolcová, Iva; Kernová, V.

    2012-01-01

    Roč. 47, Suppl. 1 (2012), s. 414-414 ISSN 0020-7594. [International Congress of Psychology /30./. 22.07.2012-27.07.2012, Cape Town] R&D Projects: GA ČR GAP407/10/2410 Institutional support: RVO:68081740 Keywords : well-being * Czech population sample * determinants Subject RIV: AN - Psychology

  10. Lange and Hayek revisited: lessons from Czech voucher privatization

    Czech Academy of Sciences Publication Activity Database

    Hanousek, Jan; Filer, Randall K.

    2002-01-01

    Roč. 21, č. 3 (2002), s. 491-498 ISSN 0273-3072 Institutional research plan: CEZ:AV0Z7085904 Keywords : Czech Republic * voucher privatization Subject RIV: AH - Economics http://search. ebscohost .com/login.aspx?direct=true&db=a9h&AN=6463493&site=ehost-live

  11. State of corruption in transition: case of the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Lízal, Lubomír; Kočenda, Evžen

    2001-01-01

    Roč. 2, č. 2 (2001), s. 137-160 ISSN 1566-0141 R&D Projects: GA AV ČR KSK9058117 Institutional research plan: CEZ:AV0Z7085904 Keywords : Czech Republic * transition * corruption Subject RIV: AH - Economics

  12. Text comprehension in Czech fourth-grade children with dyslexia

    Directory of Open Access Journals (Sweden)

    Špačková Klára

    2017-01-01

    Full Text Available In the Czech Republic, the concept of dyslexia is used as a global term for various developmental deficiencies relating to reading skills. The criteria used for dyslexia are not clear and intervention is solely focused on word reading training. Not much is known about the pattern and level of reading comprehension abilities among Czech readers. The study examines reading comprehension and its component skills (decoding and listening comprehension abilities in 32 Czech fourth-grade children with a formal diagnosis of dyslexia and their classmates (N=126. In decoding tests, the children with dyslexia surprisingly lagged behind most significantly in a task concerning speed and accuracy in context reading. Contrary to expectations, the children with dyslexia also showed inferiority in a listening comprehension task. In reading comprehension measures, in comparison to the typically developing readers, the children with dyslexia achieved the best results in a oral reading comprehension task. The results are discussed with respect to Czech counselling and educational practice and the need for changes in the current support system and terminology is stressed.

  13. Approaches to transformation and social reform in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Večerník, Jiří

    2008-01-01

    Roč. 2, Spec. Iss. (2008), s. 2-6 ISSN 1802-5854 R&D Projects: GA ČR GA403/03/0339 Institutional research plan: CEZ:AV0Z70280505 Keywords : social policy * social reforms * Czech Republic Subject RIV: AO - Sociology, Demography

  14. Precipitation reconstruction for the Czech Lands, AD 1501-2010

    Czech Academy of Sciences Publication Activity Database

    Dobrovolný, Petr; Brázdil, Rudolf; Trnka, Miroslav; Kotyza, O.; Valášek, H.

    2015-01-01

    Roč. 35, č. 1 (2015), s. 1-14 ISSN 0899-8418 R&D Projects: GA ČR GA13-04291S; GA ČR GA13-19831S Institutional support: RVO:67179843 Keywords : documentary evidence * instrumental data * precipitation * reconstruction * Czech Lands Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 3.609, year: 2015

  15. Czech Soldiers during the Great War (1914-1918)

    Czech Academy of Sciences Publication Activity Database

    Hladký, Ladislav

    2016-01-01

    Roč. 24, č. 3 (2016), s. 71-83 ISSN 0354-6497 Institutional support: RVO:67985963 Keywords : first world war * Austria-Hungary * Czech soldiers * eastern (Russian) front * southwest (Italian) front * Czechoslovak legionnaries * Czechoslovakia Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  16. Innovative Physics Teaching Conferences in the Czech Republic

    Science.gov (United States)

    Milbrandt, Rod

    2010-01-01

    Even today, with all of the instant communication technologies available, we are still often unaware of all that happens in other parts of the world. In the middle of Europe, in the Czech Republic, physics teachers have created a couple of innovative conferences--or "workshops" might be a better term. Having attended two of each, I think…

  17. Parent Influence on Loan Pricing by Czech Banks

    Czech Academy of Sciences Publication Activity Database

    Derviz, Alexis; Raková, M.

    2012-01-01

    Roč. 21, č. 4 (2012), s. 434-449 ISSN 1210-0455 Institutional support: RVO:67985556 Keywords : multinational bank * interest rate * internal capital market Subject RIV: AH - Economics Impact factor: 0.561, year: 2012 http://library.utia.cas.cz/separaty/2013/E/derviz-parent influence on loan pricing by czech banks.pdf

  18. Studying the early modern landscape in the Czech republic

    Czech Academy of Sciences Publication Activity Database

    Chodějovská, Eva

    2012-01-01

    Roč. 38, č. 1 (2012), s. 63-98 ISSN 0323-0988 R&D Projects : GA ČR(CZ) GBP410/12/G113 Institutional support: RVO:67985963 Keywords : historical landscape * early modern period * czech research Subject RIV: AB - History

  19. Comparative Advertising in the Czech Republic: An Empirical Study

    Directory of Open Access Journals (Sweden)

    Petr Kral

    2016-12-01

    Full Text Available Comparative advertising had been traditionally banned in most EU countries and was allowed by the European law just relatively recently. That is why in the EU this form of advertising is relatively new, as opposed to the situation in the US, where comparative advertising has been widely used and well accepted by consumers for decades. The literature has been silent on the topic of the effectiveness of comparative advertising in the Czech Republic, as well as in other Central and Eastern European countries. The goal of this paper is to investigate the effectiveness of comparative advertising campaigns in the Czech Republic. Using an online survey with 160 Czech respondents, we found that the attitude towards comparative advertising is rather positive in the Czech Republic. We also identified that the gender of the recipient influences the general perception of comparative advertising. On the other hand, the age of the recipient does not seem to be a moderator of the attitude towards comparative advertising, in general. The results also do not signal any impact of the gender and the age of the recipient on the change of the perception of any of the brands involved in the campaign. Managerial implications target mainly marketing and advertising managers responsible for Central European markets.

  20. The Czech Consulting company entering the Ukrainian market

    OpenAIRE

    Shokalo, Oles

    2009-01-01

    The goal of this diploma paper is to present Business Consulting, describe characteristics of european and global consultancy market, give detailed description of the Ukrainian consultancy market and finally to propose the strategic steps necessary for the Czech consultancy company with intention to enter the Ukrainian market.

  1. Analysis of price interactions between Czech and world wheat markets

    Directory of Open Access Journals (Sweden)

    Pavel Syrovátka

    2010-01-01

    Full Text Available The paper is focused on the analysis of the price interactions between the Czech and world markets for the wheat. The long-term interactions of the wheat market prices were tested by means of the co-integration analysis (Engle-Granger test. The dynamic autoregressive model developed by the author was used for evaluation of the short-term price interactions. Monthly time series of the market prices from January 1995 till April 2010 were obtained from the Czech Statistical Office and the International Monetary Fund. The results of the co-integration analysis showed, that the price dynamics in the world wheat market does not have a long-term impact on the level of prices in the Czech market for the given commodity. According to the constructed and statistically verified model, the short-term price interactions between the studied markets are not strong too. The value of the determination index (0.5063 implies other factors forming the price dynamics of the Czech wheat market.

  2. Measuring economics research in the Czech Republic: a comment

    Czech Academy of Sciences Publication Activity Database

    Münich, Daniel

    -, č. 300 (2006), s. 1-23 ISSN 1211-3298 Institutional research plan: CEZ:AV0Z70850503 Keywords : impact factor * measuring research * Czech Republic Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp300.pdf

  3. Nuclear medicine training and practice in the Czech Republic

    Energy Technology Data Exchange (ETDEWEB)

    Kaminek, Milan; Koranda, Pavel [University Hospital Olomouc, Department of Nuclear Medicine, Olomouc (Czech Republic)

    2014-08-15

    Nuclear medicine in the Czech Republic is a full specialty with an exclusive practice. Since the training program was organized and structured in recent years, residents have had access to the specialty of nuclear medicine, starting with a two-year general internship (in internal medicine or radiology). At present, nuclear medicine services are provided in 45 departments. In total, 119 nuclear medicine specialists are currently registered. In order to obtain the title of Nuclear Medicine Specialist, five years of training are necessary; the first two years consist of a general internship in internal medicine or radiology. The remaining three years consist of training in the nuclear medicine specialty itself, but includes three months of practice in radiology. Twenty-one physicians are currently in nuclear medicine training and a mean of three specialists pass the final exam per year. The syllabus is very similar to that of the European Union of Medical Specialists (UEMS), namely concerning the minimum recommended numbers for diagnostic and therapeutic procedures. In principle, the Czech law requires continuous medical education for all practicing doctors. The Czech Medical Chamber has provided a continuing medical education (CME) system. Other national CMEs are not accepted in Czech Republic. (orig.)

  4. Educational expansion and inequality in Taiwan and the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Smith, Michael; Tsai, S. L.; Matějů, P.; Huang, M. H.

    2016-01-01

    Roč. 60, č. 2 (2016), s. 339-374 ISSN 0010-4086 R&D Projects: GA ČR GCP404/12/J006 Institutional support: RVO:67985998 Keywords : educational inequality * Taiwan * Czech Republic Subject RIV: AH - Economics Impact factor: 1.231, year : 2016

  5. Thematic tourism vs. mass tourism in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Červinka Michal

    2014-01-01

    Full Text Available The article titled Thematic Tourism vs. Mass Tourism in the Czech Republic is concerned with the relationship between thematic tourism, mass tourism and presuppositions of the tourism development. The authors aim is to compare the turnout of thematic tourism attractions and sights focused on mass tourism paying attention to presuppositions of the tourism development and barriers for the turnout of thematic monuments. Comparisons will be based on presuppositions of tourism development and will be based especially on the specifics of thematic tourism - as a marginal field within the tourism industry. The application part will focus on the comparison of sights with massive turnout in the Czech Republic and thematic landmarks as the subject of thematic tourism. Special attention will be paid to the comparison of the two most visited monuments in the Czech Republic as for mass tourism - the Charles Bridge, and the most visited monument as for thematic tourism - the hydro-power plant Dlouhé Stráně, a technical representative of thematic tourism. Both monuments were elected by general public on the list of Seven Wonders of the Czech Republic in 2013. The aim is to confirm / refute the hypothesis that quality preconditions of tourism development are essential for the development of tourism and visiting tourist attractions. The article will use secondary data analysis methods and author's own field research.

  6. Distributions of vascular plants in the Czech Republic. Part 3

    Czech Academy of Sciences Publication Activity Database

    Kaplan, Zdeněk; Danihelka, Jiří; Lepší, M.; Lepší, P.; Ekrt, L.; Chrtek, Jindřich; Kocián, J.; Prančl, Jan; Kobrlová, L.; Hroneš, M.; Šulc, Václav

    2016-01-01

    Roč. 88, č. 4 (2016), s. 459-544 ISSN 0032-7786 R&D Projects: GA ČR GB14-36079G Institutional support: RVO:67985939 Keywords : distribution * vascular plants * Czech Republic Subject RIV: EF - Botanics Impact factor: 3.000, year: 2016

  7. Nuclear medicine training and practice in the Czech Republic

    International Nuclear Information System (INIS)

    Kaminek, Milan; Koranda, Pavel

    2014-01-01

    Nuclear medicine in the Czech Republic is a full specialty with an exclusive practice. Since the training program was organized and structured in recent years, residents have had access to the specialty of nuclear medicine, starting with a two-year general internship (in internal medicine or radiology). At present, nuclear medicine services are provided in 45 departments. In total, 119 nuclear medicine specialists are currently registered. In order to obtain the title of Nuclear Medicine Specialist, five years of training are necessary; the first two years consist of a general internship in internal medicine or radiology. The remaining three years consist of training in the nuclear medicine specialty itself, but includes three months of practice in radiology. Twenty-one physicians are currently in nuclear medicine training and a mean of three specialists pass the final exam per year. The syllabus is very similar to that of the European Union of Medical Specialists (UEMS), namely concerning the minimum recommended numbers for diagnostic and therapeutic procedures. In principle, the Czech law requires continuous medical education for all practicing doctors. The Czech Medical Chamber has provided a continuing medical education (CME) system. Other national CMEs are not accepted in Czech Republic. (orig.)

  8. Geochemical reactivity of rocks of the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Chuman, T.; Gürtlerová, P.; Hruška, Jakub; Adamová, M.

    2014-01-01

    Roč. 10, č. 2 (2014), s. 341-349 ISSN 1744-5647 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0073 Institutional support: RVO:67179843 Keywords : geochemical reactivity * Czech Republic * susceptibility to weathering Subject RIV: EH - Ecology, Behaviour Impact factor: 1.193, year: 2014

  9. Spatial relationships of heavy rains in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Bek, S.; Ježek, J.; Bližňák, Vojtěch

    2010-01-01

    Roč. 25, - (2010), s. 85-90 ISSN 1680-7340 Grant - others:GAUK(CZ) 43-259155; GAUK(CZ) 43-258018 Institutional research plan: CEZ:AV0Z30420517 Keywords : Convective rainfalls * orography * weather radar * Czech Republic Subject RIV: DG - Athmosphere Sciences, Meteorology

  10. Educational Expansion and Inequality in Taiwan and the Czech Republic

    Science.gov (United States)

    Smith, Michael; Tsai, Shu-Ling; Mateju, Petr; Huang, Min-Hsiung

    2016-01-01

    This article presents a comparative analysis of educational inequality by family background and gender in Taiwan and the Czech Republic, which have both experienced substantial educational expansion in the last half-century under different educational systems. We highlight the specific institutional histories of both countries and examine the role…

  11. Ownership Principle in the Foreign Trade Statistics: Czech Approach

    Directory of Open Access Journals (Sweden)

    Marek Rojíček

    2012-03-01

    Full Text Available The Czech Republic is a small open economy, which is vitally dependent on its export performance. In the period after EU accession the intensity of international cooperation grew rapidly in all the Central European countries, which is mostly the result of the huge FDI inflow at the beginning of the decade. In this context onesignificant problem for the Czech Republic and some other countries of the region appeared: the valuation of the trade flows based on the cross-border measuring overestimates the country’s trade balance in comparison with its value added created. This is the case of trade declared by non-resident units, which is more and more common within the European Union. This phenomenon is even enhanced by strategic geographical location of the Czech Republic, which is an important factor explaining why a lot of this “quasi-transit” trade is beingoperated. The revision of the foreign trade data, which aim is to follow more consistently the ownership approach, significantly changes the picture of the Czech economy, specifically the role of external demand to the economic growth.

  12. Development of achievement disparities in Czech primary and secondary education

    Czech Academy of Sciences Publication Activity Database

    Straková, Jana

    2010-01-01

    Roč. 2, č. 1 (2010), s. 53-71 ISSN 1866-6671 R&D Projects: GA ČR GA403/08/0109 Institutional research plan: CEZ:AV0Z70280505 Keywords : Educational inequalities * Czech Republic * compulsory education Subject RIV: AO - Sociology, Demography http://www.j-e-r-o.com/index.php/jero/article/view/82

  13. The parliamentary election in the Czech Republic, June 2006

    Czech Academy of Sciences Publication Activity Database

    Plecitá-Vlachová, Klára; Stegmaier, M.

    2008-01-01

    Roč. 27, č. 1 (2008), s. 179-184 ISSN 0261-3794 Institutional research plan: CEZ:AV0Z70280505 Keywords : parliamentary elections * Chamber of Deputies * Czech Republic Subject RIV: AO - Sociology, Demography Impact factor: 1.077, year: 2008

  14. Religion: An Unsolved Problem for the Modern Czech Nation

    Czech Academy of Sciences Publication Activity Database

    Nešporová, Olga; Nešpor, Zdeněk

    2009-01-01

    Roč. 45, č. 6 (2009), s. 1215-1237 ISSN 0038-0288 R&D Projects: GA ČR GA403/08/0720 Institutional research plan: CEZ:AV0Z70280505 Keywords : Czech lands * religion * sociology of religion Subject RIV: AO - Sociology, Demography Impact factor: 0.562, year: 2009

  15. Monetary transmission and the financial sector in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Havránek, T.; Horváth, R.; Matějů, Jakub

    2012-01-01

    Roč. 45, č. 3 (2012), s. 135-155 ISSN 1573-9414 R&D Projects: GA MŠk(CZ) SVV 265801/2012 Institutional support: PRVOUK-P23 Keywords : transmission mechanism * monetary policy * Czech Republic Subject RIV: AH - Economics

  16. Permeability of Czech-Polish Border Using by Selected Criteria

    Czech Academy of Sciences Publication Activity Database

    Kolejka, Jaromír; Zyszkowska, K.; Batelková, Kateřina; Ciok, S.; Dolzblasz, K.; Kirchner, Karel; Krejčí, Tomáš; Raczyk, A.; Spaller, W.; Zapletalová, Jana

    2015-01-01

    Roč. 10, č. 1 (2015), s. 51-65 ISSN 1842-5135 Institutional support: RVO:68145535 Keywords : natural barrier * cross border co-operation * population pressure * border segments * Poland and Czech Republic Subject RIV: DE - Earth Magnetism, Geodesy, Geography http://technicalgeography.org/pdf/1_2015/06_kolejka.pdf

  17. The Czech Republic's banking sector: emerging from turbulent times

    Czech Academy of Sciences Publication Activity Database

    Hájková, Dana; Hanousek, Jan; Němeček, L.

    2002-01-01

    Roč. 7, č. 1 (2002), s. 55-72 ISSN 0257-7755 Institutional research plan: CEZ:AV0Z7085904 Keywords : Czech Republic * banking Subject RIV: AH - Economics http://www.eib.org/attachments/efs/eibpapers/eibpapers_2002_v07_n01_en.pdf#page=56

  18. Czech Republic – the type material of spiders (Araneae)

    Czech Academy of Sciences Publication Activity Database

    Růžička, Vlastimil; Kůrka, A.; Buchar, J.; Řezáč, M.

    2005-01-01

    Roč. 174, 1-4 (2005), s. 13-64 ISSN 0139-9543 R&D Projects: GA AV ČR(CZ) IAA6007401 Institutional research plan: CEZ:AV0Z50070508 Keywords : spiders * type material * Czech Republic Subject RIV: EG - Zoology

  19. Extent Matters: Exposure to Sexual Material among Czech Adolescents

    Science.gov (United States)

    Ševcíková, Anna; Šerek, Jan; Machácková, Hana; Šmahel, David

    2013-01-01

    Adolescents use media that exposes them to sexual material. This study focused on adolescents in the Czech Republic, a country with relatively high rates of exposure to sexual material (ESM). A sample of adolescents aged 11 to 15 years ("N" = 495) taken from the project EU Kids Online II was examined for predictors of the following:…

  20. Parasitic helminths of reptiles (Reptilia) in South Moravia (Czech Republic).

    Science.gov (United States)

    Borkovcová, M; Kopriva, J

    2005-01-01

    An helminthological investigation of 104 reptile species was carried out in south Moravia (Czech Republic). We examined Lacerta viridis, L. agilis, Anguis fragilis, Natrix natrix, Coronella austriaca and Vipera berus. Twelve species of parasites were found. Among these, Nematoda occurred most often, followed by Trematoda and Cestoda. No Acanthocephala were detected.

  1. Integrated assessment of ecosystem services in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Frélichová, Jana; Vačkář, David; Pártl, Adam; Loučková, Blanka; Lorencová, Eliška

    2014-01-01

    Roč. 8, jun (2014), s. 110-117 ISSN 2212-0416 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0073; GA TA ČR TD010066 Institutional support: RVO:67179843 Keywords : ecosystems * ecosystem services * integrated assessment * database * valuation * Czech Republic Subject RIV: EH - Ecology, Behaviour

  2. A Comparative Analysis of Polish and Czech International New Ventures

    Directory of Open Access Journals (Sweden)

    Lidia Danik

    2016-06-01

    Full Text Available The goal of this paper is to compare the characteristics of Polish and Czech companies which follow the Born Global internationalization model. More concretely, the analysis aims to discover the differences or similarities in terms of the internationalization paths of Polish and Czech SMEs in the characteristics of their managers in terms of the so-called “international vision” and in their innovativeness level. The introductory part of article provides a description of this internationalization model and the International New Ventures traits (INV and summarizes the recent studies on this topic conducted in Poland and Czech Republic. In the empirical part, the International New Ventures from the two countries are compared. The Polish sample includes 105 companies which were surveyed with use of computer assisted telephone interviews in autumn 2014. For the Czech Republic, the sample consists of 54 small and medium-sized companies, which were surveyed using the computer assisted web interviews from November 2013 till January 2014. The surveyed companies in both countries fulfilled the definition of Born Globals. Descriptive statistics, cross-tabulation analysis and non-parametric tests are applied to accomplish the goals of the paper.

  3. The economic results of farms in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Jaroslav Svoboda

    2014-12-01

    Full Text Available Czech agrarian sector has undergone significant changes during last ten years. Since the Czech Republic has entered the European Union in 2004, agrarian sector has had to adapt to conditions of the Common Agricultural Policy (CAP. This policy is taken as a crucial within the EU policies as it includes orientation of food production as well as a broader sense of sustainable development and employment. The paper assesses profit/loss and its efficiency of a sample of farms in the Czech Republic (about 830 farms in 2004 2010. This analysis employed methods of financial analysis both traditional ratios and systems of bankruptcy and value models. Time series is long enough to monitor results after establishing the UE and the CAP principles in the Czech Republic. The paper shows that although since 2004, revenue per employee has been increasing, the value added per worker has been static without any major changes. However, farms on average were profitable with the exception of 2009. It was verified by bankruptcy and value models that an average farm is in a relatively good financial situation (without any problems or debt and sufficiently liquid.

  4. Tangible fixed assets from the perspective of Czech accounting standards

    OpenAIRE

    Dolejší, Lukáš

    2010-01-01

    The thesis is focused on accounting of tangible fixed assets from the perspective of Czech accounting standards. The aim is to describe accounting for acquisition, usage and disposal of tangible fixed assets. The thesis also analyzes different kinds of tangible fixed assets valuation and depreciation. Theoretical knowledge is applied to accounting of tangible fixed assets by Bohemia Asfalt, Ltd.

  5. Nuclear medicine training and practice in the Czech Republic.

    Science.gov (United States)

    Kamínek, Milan; Koranda, Pavel

    2014-08-01

    Nuclear medicine in the Czech Republic is a full specialty with an exclusive practice. Since the training program was organized and structured in recent years, residents have had access to the specialty of nuclear medicine, starting with a two-year general internship (in internal medicine or radiology). At present, nuclear medicine services are provided in 45 departments. In total, 119 nuclear medicine specialists are currently registered. In order to obtain the title of Nuclear Medicine Specialist, five years of training are necessary; the first two years consist of a general internship in internal medicine or radiology. The remaining three years consist of training in the nuclear medicine specialty itself, but includes three months of practice in radiology. Twenty-one physicians are currently in nuclear medicine training and a mean of three specialists pass the final exam per year. The syllabus is very similar to that of the European Union of Medical Specialists (UEMS), namely concerning the minimum recommended numbers for diagnostic and therapeutic procedures. In principle, the Czech law requires continuous medical education for all practicing doctors. The Czech Medical Chamber has provided a continuing medical education (CME) system. Other national CMEs are not accepted in Czech Republic.

  6. Occupational structure in the Czech lands under the second serfdom

    Czech Academy of Sciences Publication Activity Database

    Klein, Alexander; Ogilvie, S.

    2016-01-01

    Roč. 69, č. 2 (2016), s. 493-521 ISSN 0013-0117 R&D Projects: GA ČR GA13-13848S Institutional support: RVO:67985998 Keywords : occupational structure * Czech lands * Bohemia Subject RIV: AH - Economics OBOR OECD: Applied Economics, Econometrics Impact factor: 1.233, year: 2016

  7. Profitable Nonprofits? Reward-Based Crowdfunding in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Makýšová Lucia

    2017-12-01

    Full Text Available This paper deals with crowdfunding as a new and alternative mechanism of nonprofit funding which has thus far attracted little scholarly attention in the Czech context. It focuses on the factors that affect a campaign’s overfunding rate and determines whether these factors are consistent among different forms of project creators. A comprehensive analysis of reward-based crowdfunding in the Czech Republic was conducted based on the data from 617 projects using the Czech crowdfunding platform Hithit that were categorized according to the status of the project creator. Using binary logistic regression, a statistic estimation on an overall sample and on a sample of purely nonprofit projects was executed in order to observe if the outcomes diff er. Th e key empirical finding is that NGOs tend to raise fewer additional funds than other forms of project creators. Except for certain specific factors, the effects of the examined factors were consistent across all samples. Th is new and innovative approach to resource insufficiency by using alternative funding sources presents an important and unexplored research gap in the (post- transitive context of nonprofit sector studies, enabling a view of policy implications for Czech NGOs.

  8. Psychosocial aspects of Czech Radon Programme

    International Nuclear Information System (INIS)

    Fojtikova, I.; Neznal, M.; Hrdy, L.

    2004-01-01

    In November 1999 a radon awareness survey was conducted among Czech republic residents to evaluate their general awareness and the factual knowledge about radon, radon measurements and radon mitigation. This survey, however, did not provide any detailed information on whether the respondents' knowledge is deep and structured or it is just a chaotic mixture of impressions. Therefore, a new survey was conducted from May to November 2001. About 20 respondents, in whose houses the long term testing for radon levels had just been finished, were interviewed. The in-depth interviews had several main aims: a) to obtain a more detailed understanding of their general awareness and factual knowledge about radon; b) to learn more about the sources of their knowledge and of their perception of the radon risk; c) to get information as to whether householders accept radon remediation, and to identify any personal, attitudinal or other variables that can influence the householder's decision; and d) to experience the direct risk communication and conceive its effectiveness. The interviews confirmed some results of the former quantitative study, e.g. increasing knowledge correlating with increasing education level. They showed that the public, overloaded with information, is not disposed to search actively for other information sources (e.g. on the Internet). People perceive their knowledge as adequate and sufficient. Their approach to gathering information is very passive. Therefore, to enhance public understanding of radiation phenomena it is necessary to make efforts, including the use of public media, otherwise radioactivity will remain shrouded in myths. These myths often lead to underestimation of the radon risk. A typical example of such underestimation is a contention that there exist long-aged healthy people who live in extreme radon concentrations. Together with the interviews, a questionnaire describing 11 presumably risky situations or practices was used. Among other

  9. Cats in Czech Rural and Urban Households

    Directory of Open Access Journals (Sweden)

    E. Baranyiová

    2006-01-01

    Full Text Available The aim of this study was to elucidate the effects of rural and urban environments on the coexistence of humans and their cats. From the obtained questionnaire data we selected the rural cats (R, n = 54 and compared them with urban cats (U, n = 144. The R group cats lived predominantly in family houses, U cats in urban apartments. The pressures of physical and social factors in the small niches of urban apartments (dwellings in Czech urban high-density living settings, though comfortable, are smaller than in numerous European countries; they prevailed in our U group resulted in statistically significant differences in only 31 (51.7% out of 60 traits under study. Among them, 15 (68.2% out of 22 concerned the conduct of household members, and 16 (42.1% out of 38 concerned the behaviour of their cats. Thus the conduct of people in U households showed relatively higher proportion of changes than the behaviour of their cats. U onwers more frequently purchased their cats (R = 24.1%, U = 48.6%, chi-square = 10.648, df = 4, p < 0.05, they kept the cat pedigrees (R = 37.0%, U = 75.4%, chisquare = 24.661, df = 1, p < 0.001, paid more attention to their cats ((R = 93.0%, U = 100.0%, chi-square = 8.950, df = 1, p < 0.005, talked to them daily (R = 87.0%, U = 98.6%, chi-square = 12.024, df = 1, p < 0.001, allowed them to use furniture (R = 77.8%, U = 100.0%, chi-square = 33.839, df = 1, p < 0.001, sleep in beds of family members (R = 61.1%, U = 95.1%, chi-square = 37.149, df = 1, p < 0.001, and celebrated their birthdays (R = 25.9%, U = 100.0%, chi-square = 7.014, df = 2, p < 0.05. Their cats were more destructive than R cats, hunted less and were less aggressive when stroked. However, they showed a slightly larger scope of aggressive behaviours and were more frequently described as nervous and restless. The nature of the significant differences found in this study indicates that the co-existence of cats with people in the urbanized world is becoming more

  10. Family Business in the Czech Republic: Actual Situation

    Directory of Open Access Journals (Sweden)

    Anastasia PETLINA

    2015-09-01

    Full Text Available Purpose of the article: The purpose of this paper is to define the actual situation of family business on the market, particularly focused on qualities of family business and its strengths or weaknesses. The object of research is the family business as an economical phenomenon. The study includes two subjects: firstly, to find out a specification of the family business, to analyze family ties within the business in accordance with the laws of the Czech Republic or to find out the current economic situation in family business and, secondly, to identify the features of family business as well as the difficulties faced thereby, lying in a base of two main components, namely the family system and the same of entrepreneurship. Methodology/methods: The article was prepared on the basis of general theoretical scientific methods, particularly on those of analysis, synthesis, analogy, comparison, generalization and deduction, or the method of expert estimates. For the analysis of the actual situation in big Czech family business enterprises, it was decided to use the secondary data of a top research-journal for this area, namely the Forbes.cz. In accordance with one of the paper goals, a SWOT analysis was applied to find out the basic strengths and weaknesses of family business. It was decided to verify the received information by interviewing several representatives of the family business in the Czech Republic. Scientific aim: The aim of scientific research is to improve the understanding of family business from the perspective of difficulties faced by family business and its economic perspectives. Findings: The results of this study have allowed the finding of a definition for the family business based on family ties and the laws of the Czech Republic. Another finding is that family business as a motor of the Czech economy has a real potencial for its development and it is able to enhance the Czech economy competitiveness on the world market. In

  11. Job satisfaction and leaving intentions of Slovak and Czech nurses.

    Science.gov (United States)

    Gurková, E; Soósová, M S; Haroková, S; Ziaková, K; Serfelová, R; Zamboriová, M

    2013-03-01

    Shortages of healthcare workers in Czech and Slovak Republics are associated with factors such as raised migration of professional nurses, decreased number of nurse graduates and ageing workforce. The specific problem is migration of Slovak nurses to the Czech Republic, motivated by higher salaries. The study aims to investigate the relationship between turnover intentions and job satisfaction among Czech and Slovak nurses and to determine how the related variables differ between the two groups. A cross-sectional descriptive survey was used to investigate the intended turnover and job satisfaction relationship among 1055 hospital nurses recruited from the Czech and Slovak Republics. Data were collected using a set of questionnaires that included questions regarding leaving intentions of nurses and The McCloskey/Mueller Satisfaction Scale; three further sets of questionnaires were used. For determining the associations between variables, the Pearson correlations and multiple regression analyses were used. For group comparisons, one-way and multifactorial analysis of variance and Pearson's Chi-square test procedure were performed. The intention to leave the workplace, the nursing profession and work abroad were predicted by the levels of satisfaction of nurses with their control/responsibility and scheduling. Czech nurses reported higher satisfaction in all subscales of the job satisfaction and less frequent intention to work abroad. An inverse relationship was confirmed between age and turnover intentions. Job satisfaction was positively associated with age and years of experience. Job satisfaction differed by all of three turnover intentions. Results highlight the importance of understanding nurses' leaving intentions and related factors and their impact on nurses' lives in both countries so that health care organizations can implement effective strategies to improve the retention of their nursing workforce. © 2012 The Authors. International Nursing Review © 2012

  12. Drought events in the Czech Republic: past, present, future

    Science.gov (United States)

    Brázdil, Rudolf; Trnka, Miroslav; Mikšovský, Jiří; Tolasz, Radim; Dobrovolný, Petr; Řezníčková, Ladislava; Dolák, Lukáš

    2017-04-01

    Droughts are, together with floods, the most important natural extremes in the Czech Republic. In the last c. 20 years even some irregular alternations of years with severe droughts on the one hand (2000, 2003, 2007, 2011-2012, 2014-2015) and severe floods on the other (1997, 1998, 2002, 2005, 2009, 2010, 2013), reflecting greater variability of the water cycle, can be observed. Great attention devoted to the study of past, present and future of droughts in the Czech Republic in a few last years allowed to obtain basic knowledge related to long-term spatial-temporal variability of droughts, combining dendrochronological, documentary and instrumental data, synoptic causes and climate forcings of droughts, case studies of important drought anomalies with significant social-economic consequences (like drought of 1947), impacts of droughts in agriculture, forestry or water management, and future droughts according to model estimates. Basic results obtained are summarised and documented by several typical examples. Such level of drought knowledge became a basis for formulation of the new research project, trying to analyse the climate forcings and triggers involved in the occurrence, course and severity of drought events in the Czech Republic in the context of Central Europe and explanations of their physical mechanisms, based on a 515-year series of drought indices reconstructed from documentary and instrumental data. Presentation of this new project for 2017-2019 is included in the second part of the paper. (This work was supported by Czech Science Foundation, project no. 17-10026S "Drought events in the Czech Republic and their causes".)

  13. SMEs Growth in the Czech Republic: Some Macroeconomic Perspectives

    Directory of Open Access Journals (Sweden)

    Christian Nedu Osakwe

    2015-01-01

    Full Text Available Small and medium enterprises (SMEs are seen as a vehicle for employment generation, wealth creation, economic growth and development in countries that have a sound investment climate. SMEs, account for approximately one-third of GDP, over 50% of the value added, 99% of the share of total registered enterprises, and represent 60% of total employment in the Czech Republic. In the light of this background, the paper explores the influence of some macroeconomic variables on SMEs growth in the Czech Republic for the period 1995–2013. In order to assess the impacts of these critical macroeconomic variables (e.g., rate of unemployment, economic growth, credit provided by the financial sector on SMEs growth, we employed an econometric technique. Our findings suggest a concave relationship between unemployment and SMEs growth in the Czech Republic. More precisely, it signifies that beyond a turning point, unemployment is likely to slow down SMEs growth in the country. Our results further hint at a positive relationship between economic growth and SMEs growth. However, our empirical estimates showed an insignificant relationship between domestic credit provided by the financial sector and SMEs growth in the country. The government of the Czech Republic should continue to provide an enabling investment climate and support for bolstering a sustainable SMEs development within the country. Similar to the extant literature, we have also implored the Czech government to do more with regard to the provision of easier access and affordable credits/loans to SMEs. We have also called for the reduction of bureaucratic bottlenecks that might have to do with SMEs legislations in the country.

  14. CZECH REPUBLIC BEHIND THE STEERING WHEEL OF THE EUROPEAN UNION: EXPLORING CHALLENGES AND OPPORTUNITIES OF THE FIRST CZECH EU PRESIDENCY

    Directory of Open Access Journals (Sweden)

    David Král

    2008-12-01

    Full Text Available The Czech Republic will be only the second of the EU members that joined in 2004 to preside over what is viewed as the most powerful and influential institution within the European structures – the Council. While technical preparations have been well underway for several years, the current political constellation inside the EU seems to be leaving certain signs of nervousness among Prague-based decision makers. The uncertainty surrounding the future of the Lisbon Treaty with the Irish ‘no’ and uncompleted ratification in the Czech Republic itself, recent controversy between the EU and Russia and not least highly complicated political situation at home are all likely to have an impact on the first, and – in the current form – perhaps also the last Czech presidency of the EU. This article will try to have a look at a critical assessment of the preparations for the Czech presidency, various factors, both internal and external, that are likely to influence its execution, as well as at its priorities as they are tabled at the moment.

  15. The Czech audit: internal consistency, latent structure and identification of risky alcohol consumption.

    Science.gov (United States)

    Sovinová, Hana; Csémy, Ladislav

    2010-09-01

    The primary aim of the study is to examine the psychometric properties and the structure of the Czech version of the Alcohol Use Disorders Identification Test (AUDIT), and to estimate the rate of risky, harmful and problematic alcohol consumers. Two large data sets were analyzed. The first was based on the application of the AUDIT as a part of a general population survey (N = 1.326; age range 18-64), the second represents data gathered by general practitioners (GPs) in the context of a pilot screening and brief advice (SBA) project in the area of Greater Prague (N = 2.589). Analyses of reliability showed satisfying internal consistency of the AUDIT (Cronbach's alpha = 0.83 for population survey and 0.77 for survey based on SBA). Principal component analyses suggest two factor solutions where one factor represents drinking patterns and the second alcohol-related problems or symptoms of dependence. The principal component analyses of both data sets led to similar factor formation. A total of 19% of the general population sample was classified as risky or harmful drinkers and 2% as problem drinkers. These figures were slightly lower in the sample of patients of general practitioners. The Czech version of the AUDIT seems to be a plausible screening instrument. The properties of the instrument suggest usefulness of the summary score for identification of the level of risk.

  16. The Uniform Data Set, Czech Version: Normative Data in Older Adults from an International Perspective.

    Science.gov (United States)

    Nikolai, Tomas; Stepankova, Hana; Kopecek, Miloslav; Sulc, Zdenek; Vyhnalek, Martin; Bezdicek, Ondrej

    2018-01-01

    Outside of the United States, international perspectives on normative data for neuropsychological test performance, within diverse populations, have been scarce. The neuropsychological test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the United States National Institute on Aging (NIA) is one of the most sensitive batteries for the evaluation of both normal cognitive aging and pathological cognitive decline. This study aimed to determine the feasibility of the Czech Neuropsychological Test Battery from the Uniform Data Set (UDS-Cz 2.0), while also evaluating the results obtained from an international perspective. This paper describes data from 520 cognitively normal participants. Regression analyses were used to describe the influence of demographic variables on UDS-Cz test performance. Cognitive performance on all measures declined with age, with patient education level serving as a protective factor. Therefore, the present study provides normative data for the UDS-Cz, adjusted for the demographic variables of age and education. The present study determines the psychometric properties of the UDS-Cz and establishes normative values in the aging Czech population, which can be used in clinical settings.

  17. Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations

    Directory of Open Access Journals (Sweden)

    Jaroslav A. Hubácek

    2017-05-01

    Full Text Available Abstract Lactase non-persistence (leading to primary lactose intolerance is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression of lactase developed, spread and participated in the adaptation to dairying. This variant is associated with lactase activity persistence, and its carriers are able to digest lactose. We compared the frequencies of lactase 13910C/T (rs4988235 genotypes in Czechs/Slavs (N = 288 and Czech Gypsies/Roma (N = 300, two ethnically different groups where this polymorphism has not yet been analysed. Allelic frequencies significantly differed between the populations (p < 0.0001. In Czechs/Slavs, the lactase persistence T allele was present in 76% of the individuals, which is in agreement with frequencies among geographically neighbouring populations. In the Czech Gypsy/Roma population, only 27% of the adults were carriers of at least one lactase persistence allele, similar to the Indian population. In agreement with this result, dairy product consumption was reported by 70.5% of Czechs/Slavs and 39.0% of the Czech Gypsy/Roma population. Both in the Czech Gypsy/Roma and in the Czech/Slavs populations, the presence of carriers of the lactase persistence allele was similar in subjects self-reporting the consumption of unfermented/fresh milk, in comparison to the others.

  18. TLD audit in radiotherapy in the Czech Republic

    International Nuclear Information System (INIS)

    Ekendahl, Daniela; Zackova, Helena

    2010-01-01

    The postal TLD audit for radiotherapy beams in the Czech Republic has been pursued by the National Radiation Protection Institute (NRPI) in Prague since 1997. From the very beginning, the aim has not been only to achieve an improvement of clinical dosimetry, but also to provide results to the State Office for Nuclear Safety (SONS), which is responsible for radiation safety in the Czech Republic. According to the Czech national recommendations issued by the SONS, each clinically used beam must undergo a calibration check performed via the postal TLD method at least once per two years. This involves 32 radiotherapy centres encompassing 62 radiotherapy treatment machines. A total of more than 1000 beam checks have been provided in this way since 1997. The origins of the Czech TLD postal audit date back to 1993. With the support of the Flemish government, a pan-European Radiation Oncology Programme for Assurance of Treatment Quality (EROPAQ) was organized for three central European countries (Poland, Hungary and Czech Republic) to link them to western European countries and to share their lessons and experiences in installing their system of quality assurance in radiotherapy. The EROPAQ coordinating and measuring centre (CMC) was set up in 1994 at the University Hospital Gasthuisberg (Leuven, Belgium) and they worked together with the Czech reference centre established to distribute TLD mailings to Czech radiotherapy centres. The methodology of TLD irradiation and evaluation within the EROPAQ was similar to that developed by the IAEA and EC network. In 1996 a total of 26 beams were checked. Only 16 (62%) of them complied with the acceptance level of ± 3% which was set for deviation between the measured and stated dose. For 5 (19%) beams major deviations (beyond ± 6%) were found which required prompt action. After the cause of the major deviations had been explained, the TLD checks were repeated. This led to improvement of the clinical dosimetry at the radiotherapy

  19. Mr. Eduard Zeman, Minister of Education, Youth and Sport, Czech Republic

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    Mr Eduard Zeman (third from left), Minister of Education, Youth and Sport, Czech Republic, visiting CERN's permanent exhibition, Microcosm, with (from left to right) Dr Rupert Leitner, ATLAS Tile Calorimetry Project Leader; Mr P. Cink, Ministry of Education, Youth and Sport; Dr Ivan Lehraus, Committee for Collaboration of the Czech Republic with CERN; and H.E. Mr Milan Hovorka, Ambassador, permanent representative of the Czech Republic to the United Nations in Geneva.

  20. Perception and Interpretation of Sustainability Among the Largest Corporations Established in the Czech Republic

    OpenAIRE

    Petr Petera; Jaroslav Wagner; Kateřina Knorová

    2016-01-01

    The paper addresses perception and interpretation of sustainability among the largest corporations established in the Czech Republic. Despite the fact that the amount of literature on sustainability is substantial, there is lack of empirical investigation into understanding sustainability among corporations established in the Czech Republic. We used qualitative methodology (semi-structured interviews) to investigate how the largest corporations established in the Czech Republic understand and...

  1. The present and the future of the tablet periodicals in Czech Republic

    OpenAIRE

    Kubíčková, Jana Ada

    2016-01-01

    The Thesis maps the Czech tablet magazine market tablet and describes possible approaches to tablet magazines' creation and distribution. First chapter outlines the historical timeline of tablet magazines development both in the Czech Republic and abroad, and maps the current situation of the Czech market. The chapter defines a concept of "strictly tablet magazine" and presents possible approaches to a production of such magazines. The following chapter analyses the concept from the new media...

  2. The energy sector abroad. Part 12. The Czech Republic. Spider in the European natural gas web

    International Nuclear Information System (INIS)

    Holwerda, B.

    1998-01-01

    The natural gas industry in the Czech Republic is one of the oldest in Europe. In the past, natural gas has played a modest role in the Czech energy supply: coal and town gas from coal and lignite were the major energy sources. However, more and more use is made of natural gas, imported from Russia (Gazprom) and Norway. Besides, the Czech natural gas distribution, transportation and storage system occupies a key position in the Central-European natural gas network

  3. Deceased donor uterus retrieval - The first Czech experience.

    Science.gov (United States)

    Froněk, J; Janousek, L; Chmel, R

    Uterus transplantation is the youngest solid organ transplantation described in the literature. This procedure is the only treatment method for congenital or acquired Absolute Uterine Factor Infertility. The method is not recognised as standard clinical care yet, there were only some 13 cases performed worldwide so far. There is only one clinical trial worldwide, which has proven both feasibility and also healthy child delivery. Czech Republic Ministry of Health permitted the uterus transplant clinical trial in 2015. The first phase of the surgical part includes performance and description of the uterus retrieval from a deceased donor. The first uterus retrieval from a deceased donor as a part of multi-organ retrieval was performed in the Czech Republic on January 13th, 2016; the case is described in the paper. uterus - transplantation - deceased - donor - retrieval.

  4. State supervision over radiation protection in the Czech Republic

    International Nuclear Information System (INIS)

    Prouza, Z.

    1998-01-01

    The paper is aimed on the organisation of state supervision over radiation protection and some aspects of the execution of state supervision over radiation protection domain. The radiation protection in the Czech Republic has been from its beginning and it is up to now based on the same principles as in the other developed countries. It was concluded that from professional, technical as well as personnel standpoint, it is essentially provided at a relevant level. Due to changes in the economical and political spheres and in the organisational structure of state administration, the system of the Czech Republic Radiation Protection is now in phase of complete re-organisation: (1) new legislative system including ALARA, QA/QC programmes implementation should be introduced into daily practice of ionizing sources users; (2) new, higher quality licensing and inspection system should be completely introduced and strengthened

  5. Risks of Mortgage Loans in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Jaroslav Tichý

    2015-10-01

    Full Text Available Indebtedness through mortgage loans is dominant of household debt in the Czech Republic. The gradual increase in the household debt level may also entail increasing credit risk assumed by banks in connection with their credit exposure to this sector. The objective of the paper is to verify the risk and identify factors that affect the credit risk development in the Czech Republic. We look for correlation between the risk development and the interest rate development. Furthermore, we verify links between the risk and the development of real estate collateral value. The paper does confirm that there are real risks associated with the potential increase in interest rates. No significant risks have been confirmed with regard to the current development of the residential property value. The paper also strives to provide an identification and verification of risks stemming from individual banks’ internal processes. It features a detailed analysis of the internal factors (aspects comprising revenue, competition, as well as distribution.

  6. Two quantitative forecasting methods for macroeconomic indicators in Czech Republic

    Directory of Open Access Journals (Sweden)

    Mihaela BRATU (SIMIONESCU

    2012-03-01

    Full Text Available Econometric modelling and exponential smoothing techniques are two quantitative forecasting methods with good results in practice, but the objective of the research was to find out which of the two techniques are better for short run predictions. Therefore, for inflation, unemployment and interest rate in Czech Republic some accuracy indicators were calculated for the predictions based on these methods. Short run forecasts on a horizon of 3 months were made for December 2011-February 2012, the econometric models being updated. For Czech Republic, the exponential smoothing techniques provided more accurate forecasts than the econometric models (VAR(2 models, ARMA procedure and models with lagged variables. One explication for the better performance of smoothing techniques would be that in the chosen countries the short run predictions more influenced by the recent evolution of the indicators.

  7. Perception of Small and Medium Entrepreneurship in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Smekalova Lenka

    2014-12-01

    Full Text Available This paper deals with small and medium enterprises in relation to the attitudes perceived by business owners in their immediate neighbourhood, society, in relation to banks and the government. The key question is the difference between entrepreneurs who started their businesses voluntarily and those who entered the business out of necessity. The majority of governmental policies, including Czech policies, focus more on the questions of financial support, however the support of entrepreneurs can be broader and may include the efforts to influence perception of an individual and the society so that they have a more positive attitude towards entrepreneurial activities. The attitudes in the Czech Republic are so far rather negative and such a change may be positively reflected in the level of the entrepreneurial activity which strongly affects economic development.

  8. [Current issues of assisted reproduction in the Czech Republic].

    Science.gov (United States)

    Ventruba, P; Žáková, J; Trávník, P; Crha, I; Mrázek, M; Rumpík, D; Štěpán, J; Režábek, K; Mardešić, T; Malenovská, A; Veselá, K; Brandejská, M

    2013-08-01

    Participants of the lunch table discussion held during the 22nd symposium of assisted reproduction in Brno discussed some current topics of assisted reproduction. DISCUSSED TOPICS: More than 150 participants at round tables discussed 10 topics: 1. IVF in native AR cycle,2. observation of the embryo development dynamics, 3. evaluation and support of endometrial receptivity,4. increased number of elective single embryo transfers (eSET), 5. transport of gametes and embryos in the Czech Republic and between the Czech Republic and abroad, 6. National registry of assisted reproduction,7. new view on sperm pathology, 8. problems with the SAR membership records, 9. surogacy motherhood and 10. preimplantation genetic diagnosis and preimplantation genetic screening. All findings were presented in the afternoon session. Some of the topics brought concrete results. Some topics could not be clearly concluded and will be the subject of further discussions. A brief summary of those discussion conclusions presents this paper.

  9. Increased Sorting and Wage Inequality in the Czech Republic

    DEFF Research Database (Denmark)

    Eriksson, Tor; Pytlikova, Mariola; Warzynski, Frederic Michel Patrick

    2013-01-01

    This paper makes use of a linked employer–employee dataset to examine the evolution of wage inequality in the Czech Republic during 1998–2006. We find evidence of slightly increasing returns to human capital and diminishing gender inequality and document sharp increases in both within......-firm and between-firm inequality. We investigate several hypotheses to explain these patterns: increased domestic and international competition, decentralized wage bargaining, skill-biased technological change and a changing educational composition of the workforce. Domestic competition is found to lower within......-firm inequality whereas we find no evidence that increased international trade at the industry level is associated with higher betweenor within-firm wage inequality. The key factors driving the observed increase in wage inequality are increased educational sorting and the inflow of foreign firms to the Czech...

  10. Development of new Czech autoinjector with oxime HI-6 DMS

    International Nuclear Information System (INIS)

    Kuca, K; Jun, D.; Kassa, J.; Marek, J.; Stodulka, P.; Musilek, K.; Dolezal, D.; Povraznik, J.

    2009-01-01

    Oxime HI-6 (1-(2-(hydroxyiminomethyl)pyridinium) -3-(4-carbamoylpyridinium)-2-oxapropane) is considered to be currently the most universal oxime for the potential use as antidote against nerve agents (sarin, cyclosarin, VX, etc.). None of other commercially available oximes (pralidoxime, obidoxime, trimedoxime, MMB4) has broader antidotal effect. Due to this, development of the appropriate salt of this oxime together with its application form (eg. autoinjector) was the main aim of our departments and several private Czech companies (VAKOS XT as., Decomkov Praha sro., ChemProtect as.). In our contribution, we would like to summarize all the steps which were already done. We would like to thank to the Ministry of Industry and Trade of the Czech Republic for the Project No. FIIM2/104.(author)

  11. The Main Reasons for Implementing BPM in Czech Companies

    Directory of Open Access Journals (Sweden)

    Tucek David

    2015-09-01

    Full Text Available This article focuses on describing the main aspects and reasons for implementing Business Process Management in Czech companies, and was based on original results of the quantitative research evaluating aspects of process management in the context of company strategies in Czech enterprises which was carried out in 2006 with regard to the extension of its further utilization. Following the interest of professionals in practice, the research continued and was re-implemented in 2012, having the interviews completed in 2013. I have described an evaluation of a process segmentation typology in this article too. The analysis showed that managers have more options regarding process segmentation to choose from. In terms of practicality and ease of use, the method of process segmentation most frequently used (managerial, main and supportive comes directly from the requirements of ISO 9001.

  12. Occurrence of nepoviruses in Rubus species in the Czech Republic.

    Science.gov (United States)

    Spak, J; Kubelková, D; Honetslegrová-Fránová, J

    1997-06-01

    The occurrence of arabis mosaic virus (AMV), raspberry ringspot virus (RRV), tomato black ring virus (TBRV), strawberry latent ringspot virus (SLRV) and cherry leaf roll virus (CLRV) in cultivated and wild plants of raspberry and blackberry has been studied in the Czech Republic in 1993-1996. Five hundred and seventy samples were collected at 51 localities and assayed by double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA). The results represent the first evidence on the occurrence of AMV, RRV, TBRV and SLRV in cultivated Rubus species in the Czech Republic. Isolates AMV M20 and TBRV ML15 which were successfully transmitted by mechanical inoculation and characterized by reactions of differential host plants and by electron microscopy are the first isolates from Rubus from this territory. CLRV was not detected in either cultivated or wild Rubus species.

  13. Business cycle development in Czech and Slovak economies

    Directory of Open Access Journals (Sweden)

    Poměnková, J.

    2010-12-01

    Full Text Available This paper focuses on the business cycle development of Czech and Slovak economies. The main objective is to compare several methodological approaches to identify business cycles with the main theoretical sources of the economic activity movements in the analyzed periods. As both economies are of transition type, the growth business cycle concept will be considered. In this respect, deterministic as well as stochastic methods for obtaining cyclical fluctuations are applied. Czech and Slovak economies fall into the group of transition economies where the problems of insufficient number of observations and structural changes in empirical time series analysis occur. Even if there are many similarities in the institutions of both economies, the authors identified different regular periodicities of the waves. The used frequency analysis is a slightly unique approach of business cycle modeling. The analysis of business cycle movements has significant potential to improve economic policy efficiency.

  14. WORK-RELATED CULTURAL VALUES OF JAPANESE AND CZECH STUDENTS

    Directory of Open Access Journals (Sweden)

    Tobias Cramer

    2016-04-01

    Full Text Available Companies are very often confronted with external and internal cultural diversity to which they have to respond adequately. We need a deeper understanding of whether national cultures remain divergent in countries such as Japan and the Czech Republic following the pressures of globalization. One can argue that as cultures evolve they should constantly be assessed e.g., with respect to each of Hofstede‟s dimensions. By collecting data from one Eastern-European culture, the Czech Republic, and one Eastern culture, Japan, this study has re-examined Hofstede‟s (1984; 2001 cultural dimensions in these two cultures. Results suggest interesting changes have occurred in these cultures; a trend towards convergence may be derived. Explanations as well as implications are discussed.

  15. A brief history of tuberculosis in the Czech Lands.

    Science.gov (United States)

    Vargová, Lenka; Vymazalová, Kateřina; Horáčková, Ladislava

    2017-07-01

    Tuberculosis currently remains a serious medical problem, therefore increased attention is being paid to this disease. Paleopathological studies focused on the monitoring of morbid changes in skeletal remains of historical populations facilitate a detailed study of the development of this disease. They provide direct evidence of the existence of tuberculosis and its past forms. In addition to literary and iconographic sources, the present study is focused on recording the findings of bone tuberculosis in historical osteological sets from the Czech Lands and is the starting point for their detailed review. Approximately 76 cases of bone tuberculosis from the Czech Lands have been published and more or less reliably documented from 20 archeological sites dated back from the Eneolithic to the modern period. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Comparison Shopping Agents and Czech Online Customers’ Shopping Behaviour

    Directory of Open Access Journals (Sweden)

    Pilik Michal

    2016-12-01

    Full Text Available The internet has changed the lifestyles and shopping behaviours of customers. Online purchasing enables people to obtain information about products and services provided more effectively and easily, with the result that home shopping has become ordinary and usual. This paper presents part of a research focusing on online shopping customers’ behaviour in the Czech Republic. The article pertains to comparison shopping agents (CPAs, a tool which provides information to customers and helps find the best offer. The research was conducted on the basis of an online questionnaire available on an internet web page. The main results confirmed a dependency between online purchasing and the use of shopping agents, which are very popular in the Czech Republic. Almost two-thirds of online shoppers use CPAs when they engage in internet shopping. The final part of the paper addresses references and customers’ reviews as an important factor for the selection of online retailer.

  17. Comparison of particular logistic models' adoption in the Czech Republic

    Science.gov (United States)

    Vrbová, Petra; Cempírek, Václav

    2016-12-01

    Managing inventory is considered as one of the most challenging tasks facing supply chain managers and specialists. Decisions related to inventory locations along with level of inventory kept throughout the supply chain have a fundamental impact on the response time, service level, delivery lead-time and the total cost of the supply chain. The main objective of this paper is to identify and analyse the share of a particular logistic model adopted in the Czech Republic (Consignment stock, Buffer stock, Safety stock) and also compare their usage and adoption according to different industries. This paper also aims to specify possible reasons of particular logistic model preferences in comparison to the others. The analysis is based on quantitative survey held in the Czech Republic.

  18. X-ray fluorescence in research on Czech cultural monuments

    International Nuclear Information System (INIS)

    Cechak, T.; Gerndt, J.; Kopecka, I.; Musilek, L.

    2004-01-01

    Radionuclide X-ray fluorescence analysis (RXRFA), as a non-destructive method, relatively simple and allowing measurements to be carried out in situ, is an excellent tool in research on various objects of art. A range of artefacts have been investigated by our laboratory, in part for the purposes of history of art and in part as a basis for restoration works - medieval frescoes in some Czech castles and churches, metal sculptures and objects of applied art, paints and inks of old manuscripts, paintings. Some of these are among the most valuable monuments in the Czech cultural heritage. The contribution of the results of the tests to the investigation of their 'life story' and, in some cases, to their conservation, is not negligible. Later additions and repairs can be recognised, and materials and technologies that are close to their historic counterparts can be used in restoration work

  19. Should Czech Republic and Slovakia Have Rail Baltica Strategy?

    Directory of Open Access Journals (Sweden)

    Olli-Pekka Hilmola

    2011-10-01

    Full Text Available Export led economies of Slovakia and Czech Republic have shown impressive performance on activity regarding to Rail Baltica corridor countries (trade vol. incr. by 200-300 % in decade time. However, long-term plans in transportation logistics are tied upon corridors (road and rail ending to Polish sea port, Gdansk. Road transport is also favoured in large-scale in both countries in export activity. However, new environmental demands (sign. lower emissions and scarcity of oil are on the way of changing the current modus operandi. As trade of Rail Baltica countries accounts for one third of these two countries, and is constantly growing with surplus (except for Russia, Slovakia and Czech Republic are clearly in need of developing own strategy for Rail Baltica.

  20. The Czech Republic – impacts of and experience with EU membership

    Directory of Open Access Journals (Sweden)

    Ivo ŠLOSARČÍK

    2011-12-01

    Full Text Available This paper analyses the impact of the post-accession experience of the Czech Republic in the years 2004-2011. In particular, it focuses on the integration into the EU internal market, preparation for Eurozone accession, transfers from the EU budget and the formulation of the EU energy policy. In each policy area, both the impact of the existing EU regulatory framework and Czech preferences for its reforms are covered. The last section of the paper (chapter 6 describes the Czech institutional adaptation to the EU membership, in particular the 2009 Czech presidency experience.

  1. Balkanization versus europeanization - expressing ideological concepts (in Czech and Bulgarian)

    OpenAIRE

    Kačmarčíková Bakajsová, Petra

    2011-01-01

    Author's name: Petra Kačmarčíková Bakajsová School: Charles University, Prague Tha Faculty of Art Institut of Slavic and Eastern European Studies Nám. Jana Palacha 2, Praha 1, 116 38 Program: Bulgarian Studies Title: Balkanization versus Europeanization. Expressing Ideological Concepts (in Czech and Bulgarian) Consultant: Prof. PhDr. Hana Gladkova, CSc. Number of pages: 106 + attachments Number of attachments: 1 (from page 107 to page 184) Year: 2010 Key words: Europeanization, Balkanization,...

  2. Model strategy for village development in the Czech Republic

    OpenAIRE

    ROLÍNEK, Ladislav; CUDLÍNOVÁ, Eva; KLUFOVÁ, Renata; FALTOVÁ LEITMANOVÁ, Ivana; JÍLEK, Milan; ŘEHOŘ, Petr

    2015-01-01

    The model strategies discussed in this article represent different ways of possible village development in the Czech Republic. We used typologies of strategies from business strategic management for their definition. Twenty municipalities, where structured interviews were carried out with their mayors, were chosen randomly from among 100 villages where a questionnaire survey was conducted in 2012 (Faltová Leitmanová, et al., 2012). Based on the qualitative analysis of the structured interview...

  3. Lessons and Impressions of the Czech Capital Markets

    Science.gov (United States)

    2012-02-13

    Devco Ltd, Poštová Banka Jan Světlík: holds 45 percent of Vítkovice Machinery Group Karel Komárek Jr.: Chairman, KKCG-a multinational financial and...works Karel Janecek-RSJ Algorithmic Trading-a High Frequency Trading Firm. RSJ a.s. is the largest proprietary trader in the Czech Republic. RSJ

  4. Droughts in the Czech Lands, 1090–2012 AD

    Czech Academy of Sciences Publication Activity Database

    Brázdil, Rudolf; Dobrovolný, Petr; Trnka, Miroslav; Řezníčková, Ladislava; Valášek, H.; Zahradníček, Pavel; Štěpánek, Petr

    2013-01-01

    Roč. 9, č. 4 (2013), s. 1985-2002 ISSN 1814-9324 R&D Projects: GA MŠk(CZ) EE2.3.20.0248; GA ČR GA13-04291S; GA ČR GA13-19831S Institutional support: RVO:67179843 Keywords : documentary data * drought * drought indices * chronology of droughts * fluctuation * Czech Lands Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 3.482, year: 2013

  5. Determinants of Regional Entrepreneurial Activity in the Czech Republic

    OpenAIRE

    Ondřej Dvouletý; Jan Mareš

    2016-01-01

    The following study is focused on analysis of registered businesses in the 14 regions of the Czech Republic during the period of years 1995-2013. The aim of the study was to quantify factors that affect entrepreneurial activity expressed as rate of registered businesses per capita. Based on the previous empirical studies, the determinants were selected and hypothesis stated. Formed hypothesis investigated positive impact of GDP per capita, unemployment rate and R&D institutions...

  6. Development and structure of juvenile crime in the Czech Republic

    OpenAIRE

    Baščíková, Veronika

    2011-01-01

    ANGLICKÝ ABSTRAKT Development and structure of juvenile crime in the Czech Republic The purpose of my thesis is to provide a comprehensive analysis of juvenile crime, especially in view of its causes, specific features, development and structure. I am convinced that knowledge about current situation of juvenile crime helps to deal with the most important issues of this dangerous social phenomenon. The thesis is composed of five chapters, each of them divided into parts. At first, there is an ...

  7. eGovernment readiness assessment of the Czech Republic

    Directory of Open Access Journals (Sweden)

    Jana Andrýsková

    2009-01-01

    Full Text Available Modern information technologies has entered all spheres of human activities, public administration authorities are not exceptions. There has been significantly increasing tendency in using information and communication technologies since beginning of the century in public administration. Despite of some indicators, progress of public administration information systems is too slow. Several organizations are engaged of eGovernment assessment at the international level. We can find some variations in the methodologies that cause different ranking of some countries in international comparison. The main goal of this paper is to analyze and assess the present state of Czech Republic eGo­vern­ment with using both external indicators and internal indicators. eGovernment index, developed by United Nations, will be the main external indicator of eGovernment quality of the Czech Republic. It includes both potential for eGovernment development and its implementation, and it‘s the most complete international ranking at present. It is defined as average of the telecommunication infrastructure index, the human capital index and the web measure index. It represents overall country ability to engage and implement eGovernment. Internal ranking of the Czech Republic eGovernment will be based upon eGovernment level coefficient, that is defined as multi-dimensional model based on technology and communication facility index, Internet using index, using of public administration services by persons and companies, poviding obligatory information, existence of electronic re­gis­try on web pages, web pages accessability and language mutations. Selected statistic data are related to information society and using information technologies in public administration and were published on Czech Statistical Office or evaluated on the bases of previous years‘ development.

  8. Picking of foreign television formats by Czech televisions

    OpenAIRE

    Šopovová, Andrea

    2010-01-01

    This paper is concerned with one of the impacts of media globalisation and it is a picking of foreign television formats. It analyzes the structure of television programs offered by Czech television broadcasters and its change from 2005 when TV Nova and TV Prima changed their owners to international ones. After the introduction of media globalisation, the paper describes the television formats and then it includes a list of licensed television programs and a comparison of chosen programs with...

  9. Military conversion and science in the Czech Republic

    International Nuclear Information System (INIS)

    Stach, S.

    1994-01-01

    The sphere of science, research and development is undergoing the difficult process of transformation in the Czech Republic since the political changes after the Cold War occurred. The duality of the military and civil production was present in some of the industry branches and that is why the factories and linked research institutions are rather successful in reduction of military production and in transition to the civil one

  10. The future market in electricity in the Czech Republic

    International Nuclear Information System (INIS)

    Vacik, J.

    1998-01-01

    The Czech Republic has signed the Association Agreement with the European Union in early nineties and it has been the Republic's goal to accede to full membership in the European Union. In the power sector, the Directive 96/92/EC is, in this respect, the most important document. The Czech Energy Law was become effective from 1995 in a compromise form which proved to stay well short of perfection. Unfortunately, a number of articles and provisions fail to be consistent with the relevant EU documents, and even far less so with Directive 96/92/EC. The draft Energy Policy of the Czech Republic as presented officially in May 1997, has already definitely stressed some basic features of the future market in electricity. Regrettably, also in the draft Energy Policy some pressing long-term problems fail to be recognized or addressed and also areas failing to conform with the European power industry laws can be found in it. For the Czech Republic, it will be useful to utilize the experience of mainly the smaller EU countries and to proceed in pursuance of the findings of a thorough analysis and in a stepwise manner. In the first phase, it will be enough to make those moves which are common for all the conceivable solutions. Directive 96/92/EC does not prescribe a change in the structure of the existing electric power sector and far less any change in the ownership relation. In the same token, Directive 96/92/EC does not charge the member states with any duty to launch a wholesale market in electricity (pool of exchange). That is reserved under the discretion of the member states. Nowhere throughout the Directive is encountered any requirement to reduce the market strength of the dominant entities, if such exist

  11. 137Cs content in spruce wood in the Czech Republic

    International Nuclear Information System (INIS)

    Rulik, P.; Pfeiferova, V.

    2008-01-01

    The results of a survey of spruce wood contamination in the Czech Republic are presented. Fifty-one samples covering the country were taken during 2003-2004. The mean activity concentration in the dry wood is 4 Bq/kg, the maximum is 50 Bq/kg. The estimated effective dose to a person living in a flat with wooden furniture/boarding is negligible (not exceeding tenths of μSv/year). (orig.)

  12. Language of Czech Medical Reports and Classification Systems in Medicine

    Czech Academy of Sciences Publication Activity Database

    Přečková, Petra

    2010-01-01

    Roč. 6, č. 1 (2010), s. 58-65 ISSN 1801-5603 R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : terminology, * synonyms * classification systems * thesaurus * nomenclature * electronic health record * interoperability * semantic interoperability * cardiology * atherosclerosis Subject RIV: IN - Informatics, Computer Science http://www.ejbi.org/en/ejbi/article/53-en-language-of-czech-medical-reports- and - classification -systems-in-medicine.html

  13. Russian word-formation in contrast with Czech and Norwegian

    OpenAIRE

    Janda, Laura Alexis

    2010-01-01

    Although some scholarship on metonymy has mentioned examples of word-formation and some scholarship on word-formation has mentioned the presence of metonymy, to date there has been no attempt to examine the systematic role of metonymy in the domain of word-formation. This article presents an empirical study of the metonymies signalled by derivational suffixes in Russian, Czech and Norwegian. This approach facilitates cross-linguistic comparison that reveals significant differences among langu...

  14. Ethical and moral aspects of business in Czech Republic

    OpenAIRE

    Protivová, Eva

    2009-01-01

    The thesis deals with theme of morality and ethics, especially in business area. Theoretical part describes methods and instruments of integration of ethics into business. Practical part consists of three parts. First part is focused on evaluation of Czech business environment from ethical point of view. In second part author describes results of her survey, which examines primarily ethics code issues. Final part is concentrated on description of small company's business practices and on stak...

  15. The Parliamentary Election in the Czech Republic, October 2013

    Czech Academy of Sciences Publication Activity Database

    Stegmaier, M.; Linek, Lukáš

    2014-01-01

    Roč. 35, č. 1 (2014), s. 385-388 ISSN 0261-3794 R&D Projects: GA ČR(CZ) GAP408/12/1474 Institutional support: RVO:68378025 Keywords : elections * Czech republic * new parties Subject RIV: AD - Politology ; Political Science s Impact factor: 1.182, year: 2014 http://www. science direct.com/ science /article/pii/S0261379414000298

  16. Czech traditional agroforestry: historic accounts and current status

    Czech Academy of Sciences Publication Activity Database

    Krčmářová, Jana; Jeleček, L.

    2017-01-01

    Roč. 91, č. 6 (2017), s. 1087-1100 ISSN 0167-4366 R&D Projects: GA ČR(CZ) GA16-15716S Institutional support: RVO:68378076 Keywords : Agroforestry * Czech republic * Land use changes * Franciscan cadastre * Multifactorial analysis * Agriculture industrialisation Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Cultural and economic geography Impact factor: 1.170, year: 2016

  17. Analysis of foreign direct investment in the Czech Republic

    OpenAIRE

    Marcela Domesová

    2011-01-01

    The foreign direct investments are joined with the process of world globalisation. Foreign direct investments are carried out especially by multinational companies. The basic forms of the foreign direct investments are “greenfield” investments and “brownfield“ investments in the form of the privatization. The Czech Republic has shown mass inflow of foreign direct investments since 1998. The aim of the paper is to evaluate the inflow of foreign direct investments in the context of the balance ...

  18. Principles of the Proposed Czech Postal Sector Price Control Model

    OpenAIRE

    Libor Švadlenka; Aleksander Chlan

    2009-01-01

    The paper deals with the postal sector control. It resultsfrom the control theory and proves the justifiability of control inthe postal sector. Within the price control it results from E U Directive97!67/EC requirements on this control and states individualtypes of price control focusing on ineffective price controlcurrently used in the Czech postal sector (especially withindomestic services) and proposes a more effective method ofprice control. The paper also discusses the principles of the ...

  19. Analysis of the real estate market in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Hromada, Eduard

    2017-06-01

    Full Text Available The paper deals with the description of the current situation on the real estate market in the Czech Republic using several selected parameters. The structure of the real estate market is analyzed in terms of ownership, apartment size, energy intensity of the building, location and other parameters. Statistical results were obtained using the EVAL software developed by the author since 2007. This software continually collects, analyzes and evaluates advertised real estate prices in a monthly period.

  20. Household flood risk reduction in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Duží, Barbora; Vikhrov, Dmytro; Kelman, I.; Stojanov, Robert; Jakubínský, Jiří

    2015-01-01

    Roč. 18, č. 8 (2015), s. 1-6 ISSN 1381-2386 R&D Projects: GA MŠk(CZ) EE2.4.31.0056; GA MŠk(CZ) LD13032; GA MŠk(CZ) LD13033 Institutional support: RVO:67179843 Keywords : Bečva River Basin * Czech Republic * flood risk reduction * floods * household adaptation * household coping Subject RIV: AO - Sociology, Demography Impact factor: 3.085, year: 2015

  1. Personality correlates of music preferences in the Czech Republic

    OpenAIRE

    Franek, Marek

    2009-01-01

    This study examines the structure of music preferences in the sample of participants from the Czech Republic (n=521), differences in structure of music preferences among various age groups and the associations between these preferences and certain personality characteristics. The exploratory factor analysis revealed five music preference dimensions. Further analysis addressed the question how music preferences are related to personality characteristics. Preferences for these music dimensions ...

  2. Is Czech health care going to be lean?

    OpenAIRE

    Vitásková, Edita

    2015-01-01

    There is a growing interest in applying lean in healthcare. Healthcare services around the world have adopted industrial engineering methods and process improvement methodologies from the manufacturing sector, known as lean production. The aim of this paper is to provide a review of the existing literature on lean healthcare and to publish basic results of survey focused on Czech medical staff's knowledge of lean healthcare philosophy. Focus of this article is not to detail lean principles an...

  3. Administrative costs of property tax in the Czech Republic

    OpenAIRE

    Břetislav Andrlík

    2010-01-01

    The paper deals with the efficiency of property taxes in the tax system of the Czech Republic, focusing on the administrative costs of taxation on the timeline 2005 to 2008. It contains a theoretical definition of tax efficiency, and describes the types of costs connected with taxes. From this perspective it focuses on quantifying the direct administrative costs of inheritance tax, gift tax, property transfer tax and property tax. Direct measurement of administrative costs is done by using th...

  4. Identification of Units and Other Terms in Czech Medical Records

    Czech Academy of Sciences Publication Activity Database

    Zvára Jr., Karel; Kašpar, Václav

    2010-01-01

    Roč. 6, č. 1 (2010), s. 78-82 ISSN 1801-5603 R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : natural language processing * healthcare documentation * medical reports * EHR * finite-state machine * regular expression Subject RIV: IN - Informatics, Computer Science http://www.ejbi.org/en/ejbi/article/61-en-identification-of-units- and -other-terms-in-czech-medical-records.html

  5. Radar-based summer precipitation climatology of the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Bližňák, Vojtěch; Kašpar, Marek; Müller, Miloslav

    2018-01-01

    Roč. 38, č. 2 (2018), s. 677-691 ISSN 0899-8418 R&D Projects: GA ČR GA17-23773S; GA MZe QJ1520265 Institutional support: RVO:68378289 Keywords : weather radar * rain gauges * adjustment * precipitation climatology * Czech Republic Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Meteorology and atmospheric sciences Impact factor: 3.760, year: 2016 http://onlinelibrary.wiley.com/doi/10.1002/joc.5202/full

  6. Artemis JU and Eniac JU Projects with Czech Participation

    Czech Academy of Sciences Publication Activity Database

    Kadlec, Jiří; Nedvědová, K.

    -, special issue (2013), s. 6-9 ISSN 1210-9592 R&D Projects: GA MŠk(CZ) LE13020 Keywords : ARTEMIS JU * ENIAC JU * embedded systems * microelectronics * European Technology Platforms * FP7 * ICT Subject RIV: AF - Documentation, Librarianship, Information Studies http://library.utia.cas.cz/separaty/2013/ZS/kadlec-artemis ju and eniac ju projects with czech participation.pdf

  7. Safety Assessment Approach for Deep Geological Disposal in Czech Republic

    International Nuclear Information System (INIS)

    Havlová, Václava; Trpkošová, Dagmar; Hofmanová, Eva; Vokál, Antonín; Vokál, A.

    2016-01-01

    Conclusions: • Model improvement: the source term, the refinement of the geosphere transport model, the construction of individual biosphere models for each DGR candidate site, uncertainty evaluations etc.; • The model is planned to be completed in 2018 which will address in greater detail one of the potential sites for the construction of the Czech DGR; • R&D is inevitable for SA calculations; data input cannot be solitaire ⇔ feedback from SA is needed

  8. Aspects affecting flexibility of Czech managers’ leadership style

    Directory of Open Access Journals (Sweden)

    Ladislava Kuchynková

    2013-01-01

    Full Text Available The paper examines the potential aspects that affect the flexibility of Czech managers’ leadership style, because the ability to lead subordinates flexibly seems to be necessary for managerial practice in these days full of rapid change. A tool which makes it possible to determine the degree of flexibility of individual managers within the situational leadership style is represented by original method LBAII® developed by Ken Blanchard Companies, which the authors were provided with solely for this purpose. Due to the fact that research based on this method had not been conducted in the Czech Republic, an opportunity to learn new information from this field about the selected sample of Czech managers occurred. First of all, the article introduces the concept of a situational leadership style as well as an explanation of its use in practice. Subsequently it describes in detail the methodology of the authors’ primary research and presents the outcomes of a questionnaire survey conducted in the form of contingency tables and other tools (correspondence map, box plot, scatter plot, which aptly illustrate the data found. Finally, the results obtained are discussed and aspects related to the achieved scores of flexibility of the monitored managers are established based on verified hypotheses.

  9. CAS Introduction to Accelerator Physics in the Czech Republic

    CERN Multimedia

    CERN Accelerator School

    2014-01-01

    The CERN Accelerator School (CAS) and the Czech Technical University in Prague jointly organised the Introduction to Accelerator Physics course in Prague, Czech Republic from 31 August to 12 September 2014.   The course was held in the Hotel Don Giovanni on the outskirts of the city, and was attended by 111 participants of 29 nationalities, from countries as far away as Armenia, Argentina, Canada, Iceland, Thailand and Russia. The intensive programme comprised 41 lectures, 3 seminars, 4 tutorials and 6 hours of guided and private study. A poster session and a 1-minute/1-slide session were also included in the programme, where the students were able to present their work. Feedback from the students was very positive, praising the expertise of the lecturers, as well as the high standard and quality of their lectures. During the second week, the afternoon lectures were held in the Czech Technical University in Prague. In addition to the academic programme, the students had the opportunity to vis...

  10. Statistical Results of Activities Categorization in Czech Agricultural Companies

    Directory of Open Access Journals (Sweden)

    Svobodová J.

    2016-09-01

    Full Text Available In today’s competitive environment, to identify and correctly adjust the individual components of the business model is an important strategic device for every entrepreneur. This paper (preliminary study deals with different types of business models applied to the sector of small and medium-size farms in the Czech Republic. The main objective was to identify and categorize activities undertaken by Czech farmers into homogeneous clusters and offer recommendations on possible business model modification. The research was based on data from the Farm Accountancy Data Network (hereafter FADN. The principal component analysis and cluster analysis were carried out as part of the assessment, under which farms are categorized into homogeneous groups. The results showed that the farms surveyed can be categorized according to similar economic characteristics, production plans, and implementation processes into three basic clusters. The first business model is elaborated for the classic field production and various kinds of vegetable or livestock production, the second model for the special crop and livestock production, and the third one for the animal production. The use of FADN data and the fact that most Czech agricultural companies are of small- and medium-size should be taken into account as limiting factors of the study.

  11. Methods of Recruitment in the Czech and Slovak Organizations

    Directory of Open Access Journals (Sweden)

    Hana Urbancová

    2015-01-01

    Full Text Available In the existing highly competitive environment, every organization’s goal is to hire quality employees. To be able to acquire quality employees, the HR processes related to employee hiring must be conducted properly within the organization. This paper uses primary research to identify and assess recruitment methods used by organizations in the Czech Republic and Slovakia, taking the employer’s brand building into account. The research was conducted on the basis of a questionnaire distributed among Czech (n = 364 and Slovak (n = 340 organizations. The results showed that employers in the Czech Republic most frequently present themselves to potential candidates via their organizations’ websites (43.7%, positive references (38.7% and media advertisements (32.4%. A similar ranking obtains for Slovakia. Organization websites are used 47.5% of the time, positive references 42.5% of the time and media advertisements 33.2% of the time. In both countries, employees are hired for managerial positions primarily using the organization’s own resources, promoting the building of the employer’s brand.

  12. Comparing Czech and Slovak Council Newspapers’ Policy and Regulation Development

    Directory of Open Access Journals (Sweden)

    Lenka Waschkova Cisarova

    2015-12-01

    Full Text Available Council newspapers form an integral part of European media systems and, as such, have been analysed for their important contribution to the development of local politics. However, despite a recognition of the media’s important democratic function in the transition countries of Central and Eastern Europe (CEE after the fall of socialism, the consideration of council newspapers’ political role in the Czech Republic and Slovakia have been largely absent in debates surrounding the development of regulatory frameworks until recently. Interestingly, debates regarding local government transparency emerged recently (2011 in the United Kingdom, resulting in the Code of recommended practice on local authority publicity, underscoring the importance of this issue. However, developments in the aforementioned situations demonstrate divergent outcomes in such considerations: the British addressed the causes, the Czechs addressed the symptoms, and the Slovaks have yet to make any headway. This article utilizes qualitative analysis of policy and regulation documents to compare the trajectories of media policy and regulation of council publicity in the Czech Republic and Slovakia, ultimately contrasting it with developments in the UK, suggesting possible future trajectories for the development of this type of regulation in the CEE countries.

  13. Wind energy market study Eastern Europe. Czech and Slovak Republics

    International Nuclear Information System (INIS)

    Skjerk Christensen, P.

    1994-06-01

    The main objective of the THERMIE Associated Measure WE05 is to study the conditions for utilising wind power and estimate the market for wind power in Eastern Europe. This report describes the results of a study of the conditions in the Czech and Slovak republics, which has been concentrated on the following areas: A collection of information on the wind energy potential in these countries and the present structure of the power production system including costs; A search for information concerning payback prices, subsidies, etc. with relation to renewable energy sources, especially wind power, existing wind turbines and their production; An estimate of the possibilities for co-production of wind turbines by Czech, Slovak, and EC factories; A compilation of information on rules and legislation pertaining to the establishment of wind turbines and to power production by wind, e.g. regulations related to grid connections, safety, and environmental production. In order to promote the utilisation of wind power in the Czech and Slovak Republics, some recommendations based on this study may be put forward: the operation of pilot plants should be evaluated in order to compare the recorded production with that which is estimated theoretically based on measured wind data. Existing wind data should be supplemented with new measurements especially at sites that based on current knowledge may be suitable for establishing wind parks. The economic feasibility of wind power in these countries should be calculated based on the best available physical and economic data. (EG)

  14. Rivalry of Advocacy Coalitions in the Czech Pension Reform

    Directory of Open Access Journals (Sweden)

    Potůček Martin

    2016-06-01

    Full Text Available The Czech Republic, as many other countries of Central and Eastern Europe, faced and is still facing a pension-reform challenge. The diversification of pension pillars led to the massive displacements of participant contributions from the public PAYG pension pillars to the newly constructed private, defined-contribution, fully-funded pillars. In the Czech Republic, the adoption of the relevant law was preceded by serious political conflict between supporters and opponents of this step (both among different political actors and among professionals. In an analysis of the conflict we critically apply the Advocacy Coalition Framework. We work mainly with the analysis of policy documents, public statements of the individual actors and an analysis of voting on the relevant law in both chambers of the Czech Parliament towards the identification of the crystallization process of two clear-cut coalitions between actors from both sides of the spectrum. The Advocacy Coalition Framework in exploring the dynamics of the public-policy process proved to be able to explain situations where there is sharp political conflict. Through the lens of the devil-shift of both camps (advocacy coalitions with different beliefs, each fell into extreme positions within the coalition to affirm the correctness of their arguments and positions.

  15. Certification of Corporate Social Responsibility in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Eva Abramuszkinová Pavlíková

    2013-01-01

    Full Text Available Corporate social responsibility is in the focus of many companies in recent years. It becomes a way of sustainability for many companies on the market. It expresses a voluntary commitment of companies to behave responsibly to their surroundings within three pillars: economic, social and environmental one. The issue of social responsibility is developing in many European countries and European Commission is aiming at support for national CSR strategies. There are countries with highly developed CSR, on the other hand there are countries, such as the Czech Republic, where a public policy is being reformed, including discussions about CSR. This paper supports the idea that states should encourage social responsibility, as it allows businesses to become sustainable which leads to the stability of the economy. CSR activities can be focused on philanthropy, the care of the employees, the environment and transparency of economic activities. The process of CSR certification is important in the development of CSR in the Czech Republic. It allows companies to demonstrate their activities and visible achievements in this field. This paper describes the most popular types of certifications that are used in the Czech Republic and standards that do not have certification purposes, but they are very important. These are standards SA 8000, ISO 26000, ISO 9001, ISO 9004, ISO 9000, ISO 14001, ISO 14004, OHSAS 18001, IQNet SR 10 and the National Quality Policy.

  16. Processing and Representation of Different Types of Czech Affixes

    Directory of Open Access Journals (Sweden)

    Radka Julínková

    2015-12-01

    Full Text Available The study investigates the processing of morphologically complex words in Czech. In Experiment 1 we employed morphological repetition priming to test the Split Morphology Hypothesis, i.e. whether derived and inflected word forms are stored in the same or different manner in the Czech mental lexicon. The results demonstrate significantly larger priming effects for inflected forms compared to derived forms indicating distinct processing of inflection and derivation in Czech; while inflected forms are fully decomposed during language comprehension, derived forms are either not, or only partially. In Experiment 2 we addressed two research questions. First, we tested the psycholinguistic reality of the linguistic distinction between two types of inflective verbal prefixes: (a “purely” inflective aspectual prefixes (i.e. the prefix turns an imperfective verb into a perfective one as in hřešit (imp.; ‘to sin’ — zhřešit (perf. and (b derivational verbal prefixes (e.g. krátit (imp.; ‘to shorten’ — zkrátit (perf.. The results did not indicate any evidence that this distinction would be psycholinguistically grounded. Second, we examined the role of semantic transparency of the derivational prefixes in the processing. The experiment delivered evidence of slower processing of opaque derived verbs, most likely caused by double search/reanalysis.

  17. Intensity of rivalry in Czech furniture production industry

    Directory of Open Access Journals (Sweden)

    Lucie Špačková

    2012-01-01

    Full Text Available The paper focuses on furniture production industry in the Czech Republic and evaluates the influence of competition forces within this industry. These forces have a direct impact on success of competitive strategies of the firms. Furniture production industry is a typical branch occupied by numerous small and medium-sized firms. Small firms aim on satisfying domestic (or rather local demand, medium-sized and big firms are much more aiming on exports. The methodical sources for evaluation of rivalry represent particular influences defined by Porter in his model of five competitive forces. Main influences identified by Porter, which are increasing the intensity of competition in the furniture production industry in the Czech Republic include low industry concentration, relatively low diversity of competitors, decline in sales, low (or none switching costs, and existing excessive capacity within the industry. Further development will be most significantly influenced by a growing concentration of the bigger Czech producers on domestic market and overall economic development.

  18. Construction of corporate social performance indicators for Czech manufacturing industry

    Directory of Open Access Journals (Sweden)

    Marie Dočekalová

    2013-01-01

    Full Text Available This article aims to map out the level of social performance measurement of Czech companies, i.e. what social performance indicators companies monitor and what information they provide to their stakeholders and to construct alternative corporate social performance indicators. Based on an analysis of 24 corporate voluntary reports and results of an empirical research performed among 79 large companies operating in the manufacturing industry, it was found that companies partially monitor their social performance, but from the perspective of international standards (e.g. Global Reporting Initiative, International Federation of Accountants it is still insufficient. Czech companies usually provide only absolute numbers which disguise real trends and do not allow year on year comparison or comparison with other companies. Czech companies should provide a comprehensive picture of their overall performance, they should not focus only on financial indicators based on accounting data, since it is known that the performance measurement based only on financial and economic performance does not lead to long-term success and sustainability of organizations. Companies should monitor more their impact on society within which they operate. Proposed corporate social performance indicators in a measurable and thus manageable way express social issues.

  19. Development of the agricultural insurance market in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Eva Vávrová

    2010-01-01

    Full Text Available Proactive approach to risk management of agriculture companies is the way to ensure the efficiency of agricultural production even affected by natural disasters, to ensure the continuity of agricultural business and ultimately affect the level of development of rural regions. The instrument that solves the problem of reduction and elimination of risks associated with agricultural production is a systemic approach to the insurance of agricultural production, both crop insurance and livestock insurance, linked to a support program for SME in agriculture.This presented paper aims to identify and discuss the possibility of eliminating risks possibly threate­ning the agricultural production and to analyze forms of covering risks associated with agricultural production on the commercial insurance market in the Czech Republic. The paper analyzes the current situation and current development of the agricultural insurance on the insurance market in the Czech Republic.This paper was written as a part of the research project MSM 6215648904, carried out by the Faculty of Business and Economics, under the title „The Czech economics in the processes of integration and globalization, and the development of the agriculture and service sector in the new conditions of the integrated European market“, following the goals and methodology of the research project.

  20. Institutional Determinants of Private Equity Market in Czech Republic

    Directory of Open Access Journals (Sweden)

    Martina Skalická Dušátková

    2017-12-01

    Full Text Available A well-functioning private equity and venture capital market is affected by a range of institutional aspects. This study intends to answer the question on what is the current tax and legal environment for private equity and venture capital investments in Czech Republic as previous studies have emphasized that a rather poor scope of resources available. Qualitative data with content analysis proved to be the best way to assess the institutional framework. Data collection methods cover a comparative analysis of scientific literature documents and reports, as well as primary data from interviews with experts in the industry. The results of both secondary and primary data analysis were categorized and serious gaps in the institutional framework were identified and discussed. Our results indicate that the issue of legal and organisational structure suitable for private equity and venture capital funds may be resolved through a national equivalent to a Limited Partnership which has already been adopted into Czech law. However, a tax handicap was identified implying that it is necessary to amend the tax legislation so that the legal regulation extends the tax exemption. Another amendment should then be directed towards eliminating or mitigating the barriers imposed on pension. We believe that our findings provide valuable implications for the government, banks, stock exchanges and venture capital industry while formulating new strategies how to increase the level of investments in this specific environment of Czech Republic.

  1. Social Costs of Gambling in the Czech Republic 2012.

    Science.gov (United States)

    Winkler, Petr; Bejdová, Markéta; Csémy, Ladislav; Weissová, Aneta

    2017-12-01

    Evidence about social costs of gambling is scarce and the methodology for their calculation has been a subject to strong criticism. We aimed to estimate social costs of gambling in the Czech Republic 2012. This retrospective, prevalence based cost of illness study builds on the revised methodology of Australian Productivity Commission. Social costs of gambling were estimated by combining epidemiological and economic data. Prevalence data on negative consequences of gambling were taken from existing national epidemiological studies. Economic data were taken from various national and international sources. Consequences of problem and pathological gambling only were taken into account. In 2012, the social costs of gambling in the Czech Republic were estimated to range between 541,619 and 619,608 thousands EUR. While personal and family costs accounted for 63% of all social costs, direct medical costs were estimated to range from 0.25 to 0.28% of all social costs only. This is the first study which estimates social costs of gambling in any of the Central and East European countries. It builds upon the solid evidence about prevalence of gambling related problems in the Czech Republic and satisfactorily reliable economic data. However, there is a number of limitations stemming from assumptions that were made, which suggest that the methodology for the calculation of the social costs of gambling needs further development.

  2. Question marks of the Czech coal mining industry

    International Nuclear Information System (INIS)

    Dopita, M.; Pesek, J.

    1995-01-01

    An overview of brown and black coal mining in the Czech Republic is presented, and problems of the extent of coal reserves and of the profitability of deep black coal mining are discussed. Costs of coal mining in foreign countries are given. Coal mining in the Czech Republic can be expected to be loss-making unless coal prices are increased. Since coal resources in the Czech Republic are limited, additional nuclear power plants will have to be constructed or else coal for power generation will have to be imported. The environmental aspects of coal mining and burning are discussed. Medium-term and long-term solutions to reduce the environmental burden include thermal power plant desulfurization, application of the fluidized-bed combustion regime to coals with large ash and/or sulfur contents, and introduction of gas in towns and power plants. In the short run, large-scale consumers in towns and coal basins should be obliged to accumulate reserves of low-sulfur coal for later use. (J.B.). 2 tabs., 3 figs., 8 refs

  3. Enterohemorrhagic Escherichia coli as causes of hemolytic uremic syndrome in the Czech Republic.

    Science.gov (United States)

    Marejková, Monika; Bláhová, Květa; Janda, Jan; Fruth, Angelika; Petráš, Petr

    2013-01-01

    Enterohemorrhagic Escherichia coli (EHEC) cause diarrhea-associated hemolytic uremic syndrome (D+ HUS) worldwide, but no systematic study of EHEC as the causative agents of HUS was performed in the Czech Republic. We analyzed stools of all patients with D+ HUS in the Czech Republic between 1998 and 2012 for evidence of EHEC infection. We determined virulence profiles, phenotypes, antimicrobial susceptibilities and phylogeny of the EHEC isolates. Virulence loci were identified using PCR, phenotypes and antimicrobial susceptibilities were determined using standard procedures, and phylogeny was assessed using multilocus sequence typing. During the 15-year period, EHEC were isolated from stools of 39 (69.4%) of 56 patients. The strains belonged to serotypes [fliC types] O157:H7/NM[fliC(H7)] (50% of which were sorbitol-fermenting; SF), O26:H11/NM[fliC(H11)], O55:NM[fliC(H7)], O111:NM[fliC(H8)], O145:H28[fliC(H28)], O172:NM[fliC(H25)], and Orough:NM[fliC(H250]. O26:H11/NM[fliC(H11)] was the most common serotype associated with HUS (41% isolates). Five stx genotypes were identified, the most frequent being stx(2a) (71.1% isolates). Most strains contained EHEC-hlyA encoding EHEC hemolysin, and a subset (all SF O157:NM and one O157:H7) harbored cdt-V encoding cytolethal distending toxin. espPα encoding serine protease EspPα was found in EHEC O157:H7, O26:H11/NM, and O145:H28, whereas O172:NM and Orough:NM strains contained espPγ. All isolates contained eae encoding adhesin intimin, which belonged to subtypes β (O26), γ (O55, O145, O157), γ2/θ (O111), and ε (O172, Orough). Loci encoding other adhesins (efa1, lpfA(O26), lpfA(O157OI-141), lpfA(O157OI-154), iha) were usually associated with particular serotypes. Phylogenetic analysis demonstrated nine sequence types (STs) which correlated with serotypes. Of these, two STs (ST660 and ST1595) were not found in HUS-associated EHEC before. EHEC strains, including O157:H7 and non-O157:H7, are frequent causes of D+ HUS in the

  4. Enterohemorrhagic Escherichia coli as Causes of Hemolytic Uremic Syndrome in the Czech Republic

    Science.gov (United States)

    Marejková, Monika; Bláhová, Květa; Janda, Jan; Fruth, Angelika; Petráš, Petr

    2013-01-01

    Background Enterohemorrhagic Escherichia coli (EHEC) cause diarrhea-associated hemolytic uremic syndrome (D+ HUS) worldwide, but no systematic study of EHEC as the causative agents of HUS was performed in the Czech Republic. We analyzed stools of all patients with D+ HUS in the Czech Republic between 1998 and 2012 for evidence of EHEC infection. We determined virulence profiles, phenotypes, antimicrobial susceptibilities and phylogeny of the EHEC isolates. Methodology/Principal Findings Virulence loci were identified using PCR, phenotypes and antimicrobial susceptibilities were determined using standard procedures, and phylogeny was assessed using multilocus sequence typing. During the 15-year period, EHEC were isolated from stools of 39 (69.4%) of 56 patients. The strains belonged to serotypes [fliC types] O157:H7/NM[fliCH7] (50% of which were sorbitol-fermenting; SF), O26:H11/NM[fliCH11], O55:NM[fliCH7], O111:NM[fliCH8], O145:H28[fliCH28], O172:NM[fliCH25], and Orough:NM[fliCH25]. O26:H11/NM[fliCH11] was the most common serotype associated with HUS (41% isolates). Five stx genotypes were identified, the most frequent being stx2a (71.1% isolates). Most strains contained EHEC-hlyA encoding EHEC hemolysin, and a subset (all SF O157:NM and one O157:H7) harbored cdt-V encoding cytolethal distending toxin. espPα encoding serine protease EspPα was found in EHEC O157:H7, O26:H11/NM, and O145:H28, whereas O172:NM and Orough:NM strains contained espPγ. All isolates contained eae encoding adhesin intimin, which belonged to subtypes β (O26), γ (O55, O145, O157), γ2/θ (O111), and ε (O172, Orough). Loci encoding other adhesins (efa1, lpfAO26, lpfAO157OI-141, lpfAO157OI-154, iha) were usually associated with particular serotypes. Phylogenetic analysis demonstrated nine sequence types (STs) which correlated with serotypes. Of these, two STs (ST660 and ST1595) were not found in HUS-associated EHEC before. Conclusions/Significance EHEC strains, including O157:H7 and non

  5. Applicability of Hilt's law to the Czech part of the Upper Silesian Coal Basin (Czech Republic)

    International Nuclear Information System (INIS)

    Sivek, Martin; Caslavsky, Marek; Jirasek, Jakub

    2008-01-01

    Hilt's law (dependence of the coalification degree on depth) is a substantial and long-acknowledged rule. Its validity in the Czech part of the Upper Silesian Coal Basin (Carboniferous, Mississippian to Pennsylvanian - Lower Namurian to Westphalian A) is the subject of this study. It is based on over 29,000 analyses of the volatile matter moisture- and ash-free (V daf ) from surface and underground boreholes drilled in 1946-1989. Vitrinite reflectance (R max ) cannot be used as a measure of coalification in the Upper Silesian Coal Basin: the number of reflectance measurements is small and their distribution over the basin area is very uneven. Statistical data on V daf for the individual stratal units were processed. Modelling of the trends in the volatile matter moisture- and ash-free (V daf ) depending on ''stratigraphic depth'' proved the general applicability of Hilt's law. The distribution of this parameter in selected boreholes and segments of the basin was also studied, and coalification gradients were calculated. Coalification in specific examples (boreholes) is, however, highly variable and shows numerous deviations from Hilt's law even within individual boreholes, which is documented on a real example. The causes of some of the deviations are relatively well known (e.g., effect of elevated pressure in tectonically deformed areas, effect of effusive rocks or paleoweathering zones) while others can be presumed (heat flows due to Variscan and Carpathian orogenies affected by the lithology of the Carboniferous massif). The contribution of these effects in specific examples can be determined with great difficulty only. (author)

  6. The Paradox of Czech Crusaders: Will They Ever Learn the Corruption Lesson? (Corruption and Anticorruption in the Czech Republic)

    OpenAIRE

    Lubomir Lizal; Evzen Kocenda

    2001-01-01

    Corruption has a negative impact on society and economy. The transition process in Central and Eastern Europe (CEE) uncovered dormant possibilities for corruption and necessity for appropriate steps to be taken. We document the state of corruption in the Czech Republic and the measures introduced to fight it. We cover sectors of society and economy according to their importance of a consequential corruption hazard. We also described the government's program of anticorruption and its achieveme...

  7. The Extended Concept of Security and the Czech Security Practice

    Directory of Open Access Journals (Sweden)

    Libor Stejskal

    2008-12-01

    Full Text Available According to the extended concept of security, the nation state is no longer the sole privileged reference object of security. The traditional model of national security is developing from military terms to a broader concept which embraces the international, economic, social, environmental, and human rights dimensions of security. The meaning and relevance of the concept is being extended “upwards”, to international organisations, and “downwards”, to regional and local authorities, non-governmental organisations, communities, and individual citizens. This has immediate bearing on the everyday security reality of the Czech Republic. In international context, the “security frontier” of the Czech Republic is expanding, e.g. through the country’s involvement in UN and NATO security missions in conflict-ridden regions of Europe and the world. The country also helps enhance the internal security of the European Union, whose strength depends on its Member States’ willingness to “harmonise” the pursuit of their respective national security interests. This approach is especially important with regard to the principal security threats Europe faces and will continue to face in the future: terrorism and organised crime. It is vital that the Czech Republic have a well-working security system capable of responding effectively to a broad range of threats. This requirement applies first and foremost to the Police, the Fire and Rescue Service, and intelligence services. Unfortunately, with the present effectiveness of the Czech security system, much remains wishful thinking and, due to the lack of a comprehensive framework, a comparatively low level of protection against emergencies exists. Fight against crime is hampered by inefficient operation of the Police and judiciary. A thorough analysis of the aforementioned problems could provide basis for a broader public debate over the priorities and goals of Czech security policy, which should

  8. Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations

    DEFF Research Database (Denmark)

    Pruhova, Stepanka; Dusatkova, Petra; Sumnik, Zdenek

    2010-01-01

    Glucokinase diabetes, also called GCK-MODY or maturity-onset diabetes of the young type 2 (MODY2), is caused by heterozygous mutations in the gene encoding glucokinase (GCK). Objective: The aim of study was to investigate the current prevalence of GCK mutations in a large cohort of Czech patients...... with typical clinical appearance of GCK-MODY. In addition, we reanalyzed the negative results obtained previously by screening using the denaturing high-performance liquid chromatography (dHPLC)....

  9. Self-reported knowledge, attitudes, and behaviour towards hospice care and how are these related to training in palliative care: An online survey among oncologists in the Czech Republic and Slovakia

    NARCIS (Netherlands)

    Loucka, M.; Pasman, H.R.W.; Brearley, S.G.; Payna, S.A.; Onwuteaka-Philipsen, B.D.

    2015-01-01

    Oncologists have a central role as ‘gate keepers’ in terms of referring patients to palliative and hospice care. This role is even more important in countries such as the Czech Republic and Slovakia, where palliative care is still developing. The aim of this study was to assess the associations

  10. A new record of Oxychilus alliarius (Gastropoda: Zonitidae with the species distribution in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Jitka Horáčková

    2009-12-01

    Full Text Available A new finding of the land snail species Oxychilus alliarius was recorded in the Czech Republic. This West European species was found in the six isolated sites during the last thirteen years always in western part of Bohemia. This paper brings new information on the distribution of Oxychilus alliarius in the Czech Republic.

  11. Air gamma spectrometry in the radiation monitoring situation of Army of the Czech Republic

    International Nuclear Information System (INIS)

    Pavlik, J.; Sladek, P.

    2011-01-01

    In this poster authors deal with aerial radiation monitoring of territory of the Czech Republic. Army Radiation Monitoring Network (ARMS) are selected folder whirlwind Army of the Czech Republic (ACR), that are destined for the tasks of the National Radiation Monitoring Network (CRMS).

  12. Czechs and Slovaks in Russian Captivity during World War I (1914-1918)

    OpenAIRE

    Oksana E. Dmitrieva

    2013-01-01

    The article is focused on the features of more than 250 000 Czechs and Slovaks in Russian captivity during World War I: the amount, quartering and supply benefits, work in various sectors of the Russian economy, military units formation, social and national organizations activities, charity support. The conditions of Czechs and Slovaks captivity are recollected. New sources are introduced into scientific use.

  13. Shortfall of Strategic Governance and Strategic Management in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Ochrana František

    2016-12-01

    Full Text Available The article analyses the problems of strategic governance and strategic management of the Czechoslovak Government, as well as the Government of the Czech Republic in the years 1989-2016. It seeks the causes and factors that have caused the low levels of strategic governance and strategic management at the level of the ministries of the Czech Republic. It examines the problem from genetic and historical perspective, and from the organizational and human capacity to exercise strategic governance. The study is based on two pieces of empirical research within the ministries of the Czech Republic. It identifies the main cause of failure of strategic governance and strategic management at the level of the central government of the Czech Republic. These include, in particular, the persistent distrust of the ideas of strategic governance and strategic management held by the right-wing governments and the generally low capacity of governments of the Czech Republic to engage in strategic governance. The organizational structure of the central state administration lacks the strategic units that generate ideas for supporting strategic governance. The empirical research of the ministries of the Czech Republic also revealed that policy workers in Czech ministries dedicate a large proportion of their work time to operational and administrative activities at the expense of analytical and strategic activities. The changes require implementation of reforms within the public administration, which (among other things will eliminate the existing causes and inhibiting factors regarding the lack of strategic governance in the Czech Republic.

  14. Difference between Written and Spoken Czech: The Case of Verbal Nouns Denoting an Action

    Czech Academy of Sciences Publication Activity Database

    Kolářová, V.; Kolář, Jan; Mikulová, M.

    2017-01-01

    Roč. 107, č. 1 (2017), s. 19-38 ISSN 0032-6585 Institutional support: RVO:67985840 Keywords : written Czech * spoken Czech * verbal nouns Subject RIV: AI - Linguistics OBOR OECD: Pure mathematics https://www.degruyter.com/view/j/pralin.2017.107.issue-1/pralin-2017-0002/pralin-2017-0002. xml

  15. Specifics of Cyberbullying of Teachers in Czech Schools--A National Research

    Science.gov (United States)

    Kopecký, Kamil; Szotkowski, René

    2017-01-01

    This paper focuses on the results of the national research of cyberbullying of Czech teachers, which was realized in year 2016 in the entire Czech Republic. The research focused on the prevalence of cyberbullying of teachers, the impact of cyberbullying on teachers, strategies of coping with cyberbullying and methods of solving the incidents. The…

  16. Legends as a mirror to cultural identity and quality practice in the Czech Republic

    DEFF Research Database (Denmark)

    Dahlgaard, Jens Jørn; Mansfield, George; Edgeman, Rick L.

    1998-01-01

    This study is one in a series of investigations into quality improvement practices and trends in Europe. In the present piece historical influences on quality in the Czech Republic are examined. Examples from various business sectors are provided. The Czech Republic is confronted by serious busin...

  17. 'Nothing is Certain': Czech Post-War Literature Between the Avant-Garde and Expressionism

    Czech Academy of Sciences Publication Activity Database

    Říhová, Zuzana

    2016-01-01

    Roč. 14, č. 2 (2016), s. 125-140 ISSN 1479-0963 Institutional support: RVO:68378068 Keywords : collectivism, individualism, avant-garde, expressionism, Czech literature, short fiction, anxiety , fear, anthropomorphization * individualism * avant-garde * expressionism * Czech literature * short fiction * anxiety * fear * anthropomorphization Subject RIV: AJ - Letters, Mass-media, Audiovision OBOR OECD: Specific literatures

  18. Danish-Czech wind resource know-how transfer project. Interim report 2002

    DEFF Research Database (Denmark)

    Rathmann, O.; Nørgård, Per Bromand; Frandsen, Sten Tronæs

    2003-01-01

    The progress of the Danish-Czech Wind Resource Know-how Transfer Project is reported. The know-how transfer component of the project has consisted in performing a wind resource training workshop for about 13 individuals from the Czech Republic, rangingfrom scientists to wind farm project developers...

  19. Czech Green politics after two decades: the May 2010 general election

    Czech Academy of Sciences Publication Activity Database

    Jehlička, P.; Kostelecký, Tomáš; Kunštát, Daniel

    2011-01-01

    Roč. 20, č. 3 (2011), s. 418-425 ISSN 0964-4016 R&D Projects: GA ČR GAP404/10/0521 Institutional research plan: CEZ:AV0Z70280505 Keywords : Czech Green Party * politics of the Czech Republic * environmental policy Subject RIV: AO - Sociology, Demography Impact factor: 1.398, year: 2011

  20. Migration from Ukraine to the Czech Republic with Respect to the War Conflict in Eastern Ukraine

    Czech Academy of Sciences Publication Activity Database

    Uherek, Zdeněk

    -, 93/151 (2016), s. 1-16 Institutional support: RVO:68378076 Keywords : Ukraine * Czech Republic * migration * resettlement Subject RIV: AC - Archeology, Anthropology, Ethnology http://www.migracje.uw.edu.pl/publikacje/migration-from- ukraine -to-the-czech-republic-with-respect-to-the-war-conflict-in-eastern- ukraine /

  1. Study of the Readiness of Czech Companies to the Industry 4.0

    Directory of Open Access Journals (Sweden)

    Jakub Kopp

    2017-07-01

    Full Text Available The article deals with the results of the questionnaire survey that analyzes the readiness of Czech companies on the trend of the Industry 4.0. It means mainly whether Czech companies are interested in the fourth industrial revolution and whether they are ready for this trend. The readiness is expressed in defined levels.

  2. Imported resources - oil crude oil processing in the Czech Republic and its prospectives

    Energy Technology Data Exchange (ETDEWEB)

    Soucek, I.; Ottis, I. [Kaucuk, Kralupy nad Vitavou (Czechoslovakia)

    1995-12-01

    This paper examines the availability of various crude oils, addressing specifically crude oil pipelines to the Czech Republic, both existing and under construction. Secondly, the economic status of two main Czech refineries is examined in comparison to international trends, technical configurations, and product supply and demand.

  3. Difference between Written and Spoken Czech: The Case of Verbal Nouns Denoting an Action

    Czech Academy of Sciences Publication Activity Database

    Kolářová, V.; Kolář, Jan; Mikulová, M.

    2017-01-01

    Roč. 107, č. 1 (2017), s. 19-38 ISSN 0032-6585 Institutional support: RVO:67985840 Keywords : written Czech * spoken Czech * verbal nouns Subject RIV: AI - Linguistics OBOR OECD: Pure mathematics https://www.degruyter.com/view/j/pralin.2017.107.issue-1/pralin-2017-0002/pralin-2017-0002.xml

  4. Explaining the Decline in Coronary Heart Disease Mortality in the Czech Republic between 1985 and 2007

    Czech Academy of Sciences Publication Activity Database

    Bruthans, J.; Cifková, R.; Lánská, V.; O'Flaherty, M.; Critchley, J.A.; Holub, J.; Janský, P.; Zvárová, Jana; Capewell, S.

    2014-01-01

    Roč. 21, č. 7 (2014), s. 829-839 ISSN 2047-4873 Institutional support: RVO:67985807 Keywords : coronary heart disease * Czech MONICA and Czech post-MONICA * coronary heart disease management * coronary heart disease mortality * coronary heart disease risk factors Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 3.319, year: 2014

  5. Effective doses received by air crew of airlines registered in the Czech and Slovak Republics

    International Nuclear Information System (INIS)

    Kubancak, Jan; Orcikova, H.; Kovar, I.

    2013-01-01

    The results of effective dose monitoring for airlines registered in the Czech Republic since 1999 and in Slovakia since 2011 are presented. The recommended effective dose limits were apparently exceeded in over 75% Czech crew members. The dependence of the effective doses on the heliocentric potential was also examined. (orig.)

  6. How old maps are used to investigate modern environmental issues in the Czech Republic

    NARCIS (Netherlands)

    Cernajsek, T.; Hauser, C.; Posmourny, K.

    2004-01-01

    The Austrian Geological Survey and Czech geological organizations have in their archives source materials that can be used for the landscape restoration. At many places in the Czech Republic, considerable changes of the environment took place due to building and other industrial activities,

  7. Czech safety concept: 2013 state of the art

    International Nuclear Information System (INIS)

    Vokal, Antonin; Slovak, Jiri

    2014-01-01

    The Czech Republic operates four WWER 440 reactors (Dukovany) and two WWER 1000 reactors (Temelin). The four 440 MW Dukovany units were installed and began operation during the period 1985-1988. The two WWER 1000 reactors at Temelin started operation in 2002 and 2003. Currently, more than 8000 SF assemblies from WWER 440 reactors and 900 spent assemblies from WWER 1000 reactors spent fuel assemblies are stored in dry storage facilities located in the area of both NPP in approved casks or in pools at reactor sites. More than 4 000 assemblies are expected to be spent by 2025 at Dukovany reactors and 4 600 assemblies by 2042 at Temelin reactors. The multi-billion Euro contract to build two new nuclear reactors at the current site of Temelin with the option for an additional one in Dukovany has recently been launched in the Czech Republic. It is expected that more than 8 000 fuel assemblies would be spent in the three new nuclear reactors in the Czech Republic during their 60 years of electricity production. The basic reference plan is to directly dispose of all of the spent fuel assemblies in a deep geological repository (DGR), starting operation not earlier than in 2065. The DGR is planned to be located in granite host rock, because no other type of host rock in sufficient volume is available in the Czech Republic. Currently seven candidate sites for DGR suitable for geological disposal of SF assemblies have been selected, but due to negative community attitudes at the notion of have a repository in their backyard, they are still awaiting a detailed geological survey. According to proposed reference designs, SF assemblies should be in steel-based canisters emplaced in vertical or horizontal boreholes in granite host rock at approximately 500 m under the surface and surrounded by compacted bentonite. The Czech safety concept is based on the KBS-3 concept developed in Sweden. The Swedish concept is primarily based on almost thermodynamic stability of copper overpack in

  8. Physical Comorbidities in Depression Co-Occurring with Anxiety: A Cross Sectional Study in the Czech Primary Care System

    Directory of Open Access Journals (Sweden)

    Petr Winkler

    2015-12-01

    Full Text Available Comorbidities associated with depression have been researched in a number of contexts. However, the epidemiological situation in clinical practice is understudied, especially in the post-Communist Central and Eastern Europe region. The aim of this study was to assess physical comorbidities in depression, and to identify whether there are increased odds of physical comorbidities associated with co-occurring depressive and anxiety disorders. Data on 4264 patients aged 18–98 were collected among medical doctors in the Czech Republic between 2010 and 2011. Descriptive statistics were calculated and multiple logistic regressions were performed to assess comorbidities among patients with depressive disorder. There were 51.29% of those who have a physical comorbidity, and 45.5% of those who have a comorbid anxiety disorders among patients treated with depression in Czech primary care. Results of logistic regressions show that odds of having pain, hypertension or diabetes mellitus are particularly elevated at those who have co-occurring depressive and anxiety disorder. Our findings demonstrate that comorbidities associated with depressive disorders are highly prevalent in primary health care practice, and that physical comorbidities are particularly frequent among those with co-occurring depressive and anxiety disorders.

  9. The Czech Republic Sugar Market Development in the Context of the Phasing out of Sugar Quota

    Directory of Open Access Journals (Sweden)

    Kateřina Kovářová

    2017-09-01

    Full Text Available The aim of the paper is to assess the current position and situation of the Czech sugar market actors. The new situation is expected due to the declared phasing of out of sugar quota with the EU Common Agriculture Policy. The analysis is based on secondary date from the statistics of the Czech Statistical Office and the Ministry of Agriculture of the Czech Republic. Czech Republic has a long strong tradition in sugar production. It lost a leading position in the sugar market in the past. The sugar industry has been affected by various factors during several periods. The last big challenge for the market was the restricting system of the Common Agriculture Policy of the European Union. The expected development of the sugar market in the no-quota environment could be a good opportunity for both Czech sugar beet producers and sugar beet manufacturers (sugar producers.

  10. Danish-Czech wind resource know-how transfer project. Interim report 2002

    Energy Technology Data Exchange (ETDEWEB)

    Rathmann, O.; Noergaerd, P.; Frandsen, S.

    2003-12-01

    The progress of the Danish-Czech Wind Resource Know-how Transfer Project is reported. The know-how transfer component of the project has consisted in performing a wind resource training workshop for about 13 individuals from the Czech Republic, ranging from scientists to wind farm project developers, and in donating modern software for evaluating wind resources. The project has also included a review of a Czech overview-study of wind speeds inside the country as well as a study of the electricity tariffs and their impact on wind energy utilization in the Czech Republic. A problematic existing Czech wind farm project, locked up in a no-production situation, was also addressed. However, this situation turned out to be related to problems with economy and owner-ship to a higher degree than to low wind resources and technical problems, and it was not possible for the project to point out a way out of this situation. (au)

  11. Accelerator driven reactors and nuclear waste management projects in the Czech Republic

    Energy Technology Data Exchange (ETDEWEB)

    Janouch, F. [Royal Institute of Technology, Stockholm (Sweden); Mach, R. [Institute of Nuclear Physics, Rez near Prague (Czechoslovakia)

    1995-10-01

    The Czech Republic is almost the only country in the central Europe which continues with the construction of nuclear power reactors. Its small territory and dense population causes public worries concerning the disposal of the spent nuclear fuel. The Czech nuclear scientists and the power companies and the nuclear industries are therefore looking for alternative solutions. The Los Alamos ATW project had received a positive response in the Czech mass-media and even in the industrial and governmental quarters. The recent scientific symposium {open_quotes}Accelerator driven reactors and nuclear waste management{close_quotes} convened at the Liblice castle near Prague, 27-29. 6. 1994 and sponsored by the Czech Energy Company CEZ, reviewed the competencies and experimental basis in the Czech republic and made the first attempt to formulate the national approach and to establish international collaboration in this area.

  12. Student's Work: Social Capital in the Czech Republic and Public Policy Implications

    Directory of Open Access Journals (Sweden)

    Michal Vodrážka

    2009-06-01

    Full Text Available Social capital in Eastern Europe has received a fair amount of scholarly attention in recent years, including in the Czech Republic. This paper examines the stock of macro-level social capital in the Czech Republic in comparative European perspective. The notions of “missing” social capital and corruption as negative social capital are explored. The corruption situation in the Czech Republic and the progress in curbing it that was made in the last decade are evaluated. Regressions run with data from the World Value Survey and the Corruption Perception Index show that economic growth does not translate into correspondingly lower levels of corruption in the Czech case. State bureaucracy is identified as a possible reason for the failure to curb corruption successfully. Public policy recommendations and their usefulness for the Czech Republic are debated and a civil service reform is proposed as the most appropriate policy for addressing the situation.

  13. Occupational diseases in uranium and ore miners in connection with radiation exposure in the Czech Republic

    International Nuclear Information System (INIS)

    Mueller, T.

    2003-01-01

    Dozens cases of diseases are submitted to judgement as occupational diseases every year in the Czech Republic. Patients or attending physicians suggest that these cases are caused by occupational ionizing radiation. Only a part of these cases is qualified as occupational disease. The term 'occupational disease' is rather a juridical term which underlies the right to financial compensation. The causal association with exposure to ionizing radiation cannot be indisputably verified by expert medical opinion. Most diseases, which are proposed as occupational disease, are malignant tumors of the lungs. Total majority of judged cases are lung cancers from radioactive agents. In 2002, a total of 33 cases of lung cancer in former uranium or ore miners have been acknowledged as occupational diseases. The decision about occupational disease is derived from probabilistic approach based on estimation of probability of causation of irradiation on disease origin (methodical guideline No. 15 of Ministry of Health Bulletin, part 9, 1998). The presented paper gives a general information about all judged causes of occupational diseases in former uranium and ore miners in the Czech Republic in 2002. A total of 72 cases were submitted to judgement of conditions of disease origin to the National Radiation Protection Institute in 2002. 67 cases were lung cancers, 1 case was chronic myeloid leukemia, acute myeloid leukemia, basaliom, cancer of larynx and cancer of nasal septum. The probability of causation was assessed as prevailing in 32 cases of lung cancer, borderline in 5 cases and low in other 30 cases of lung cancer. The probability of causation was prevailing in both cases of myeloid leukemia. (author)

  14. GPR use and activities in the Czech Republic

    Science.gov (United States)

    Stryk, Josef; Matula, Radek

    2014-05-01

    In the field of civil engineering applications in the Czech Republic, Ground Penetrating Radar (GPR) is used particularly for the diagnostics of roads and bridges. There is no producer of GPR in the Czech Republic, sets of different producers are used, particularly Geophysical Survey Systems, Inc. (USA) and MALÅ GeoScience (Sweden). The measurement results are mostly processed by software Radan, Road Doctor Pro, ReflexW and RadEx. The only technical specification in the Czech Republic is TP 233 issued by the Ministry of Transport, which describes the diagnostics of roads by GPR. Apart from a basic description of the method and a measurement system, it mentions possible applications. The only application where accuracy is mentioned is the locating of dowels and tie bars in concrete road pavements, which states that if calibration is performed, the expected depth accuracy is up to 1.0 cm. The following R&D project is currently in progress: New diagnostics methods as a supporting decision tool for maintenance and repair of road pavements - their contribution and ways of their usage (2012-2014) The project aims to test possible non-destructive methods (particularly GPR and laser scanning), make recommendations when and how to use specific methods for individual applications and for changes in technical specifications. The following R&D projects have been recently completed: Position of dowels and tie bars in rigid pavements and importance of their correct placement to pavement performance and service life (2012-2013) The project included an analysis of individual NDT methods used for the location of dowels and tie bars and for testing of their accuracy - GPR, MIT-scan and GPR in combination with a metal detector. Multichannel ground penetrating radar as a tool for monitoring of road and bridge structures (2009-2011) The project included detection of hollow spaces under non-reinforced concrete pavements, detection of excessive amount of water in road construction

  15. Active transport among Czech school-aged children

    Directory of Open Access Journals (Sweden)

    Jan Pavelka

    2012-09-01

    Full Text Available BACKGROUND: Active transport is a very important factor for increasing the level of physical activity in children, which is significant for both their health and positive physical behaviour in adult age. OBJECTIVE: The aim of the study was to establish the proportion of Czech children aged 11 to 15 who select active transport to and from school and, at the same time, describe socio-economic and socio-demographic factors influencing active transport to and from school among children. METHODS: To establish the socio-demographic factors affecting active transport, data of a national representative sample of 11 to 15 year-old elementary school children in the Czech Republic (n = 4,425. Research data collection was performed within an international research study called Health Behaviour in School Aged Children in June 2010. Statistical processing of the results was made using a logistic regression analysis in the statistical programme IBM SPSS v 20. RESULTS: Active transport to and from school is opted for in the Czech Republic by approximately 2/3 of children aged 11 to 15. Differences between genders are not statistically significant; most children opting for active transport are aged 11 (69%. An important factor increasing the probability of active transport as much as 16 times is whether a child's place of residence is in the same municipality as the school. Other factors influencing this choice include BMI, time spent using a computer or a privateroom in a family. A significant factor determining active transport by children is safety; safe road crossing, opportunity to leave a bicycle safely at school, no fear of being assaulted on the way or provision of school lockers where children can leave their items. CONCLUSIONS: Active transport plays an important role in increasing the overall level of physical activity in children. Promotion of active transport should focus on children who spend more time using a computer; attention should also be

  16. Effectiveness of Marketing Activities in Engineering in Czech Republic

    Directory of Open Access Journals (Sweden)

    František Milichovský

    2015-06-01

    Full Text Available Purpose of the article is to present the selected data obtained from primary research, which concerns the marketing activities use in the Czech companies in view of their industry. Nowadays, high competitive environment influence permanent pressure on companies which are in turn force to monitor and adapt them in order to retain their expected market position. In article there were gained data by primary research, using a structure questionnaire survey and processing by statistical software IBM SPSS Statistics 22. The research sample consists 147 companies in 2013. All companies were operating in the Czech environment and they were chosen in random way from chosen CZ-NACE groups. The main scientific aim is to analyse the condition for realisation of marketing activities and determine whether there is a relationship between measurement of marketing effectiveness and industry field in the Czech business environment. Findings of the article point to differences in the use of individual marketing activities in view of engineering field. It was found that companies have to respect corporate goals to fill stakeholders᾿ requirements, with a small improving because of the engineering industry field. Through realisation marketing activities there are many ways how to impact target audience. Also, it was found there is only average dependency between tracking of marketing performance and engineering field. The result of the article is describing relevant approach to prove efficiency of realisation of marketing activities in relation with engineering companies. The companies know the importance of relationship with their customers. Marketing management and realisation of marketing activities has become realm where is possible to find opportunities to increase own competitiveness in view of the growing competitive environment.

  17. Cadmium exposure pathways in the Czech urban population.

    Science.gov (United States)

    Puklová, V; Batáriová, A; Cerná, M; Kotlik, B; Kratzer, K; Melichercik, J; Ruprich, J; Rehůrková, I; Speváková, V

    2005-03-01

    The article describes the exposure pathways of cadmium in the Czech urban population. The data on Cd concentrations originated from the Environmental Health Monitoring System, which has been realized in 30 cities since 1994. The data on cadmium content in particular exposure pathways - diet, drinking water, ambient air and soil -were processed for the period 1994-2003. The estimate of the daily dietary intake for an average adult population amounted to 11-19 microg/d, i.e. 0.17-0.30 microg/kg bw/d, which represents 17%-30% of the PTWI (provisional tolerable weekly intake). The contribution from drinking water to the oral exposure is low; on average 0.5 microg/d. Potential exposure to airborne Cd was estimated at about 0.02 microg/d. The additional Cd intake from urban soil ingestion probable in small children was found to be insignificant based on Cd concentrations in the soil of kindergarten playgrounds. Biomonitoring outputs characterize the recent and life-long cadmium burden of the Czech population from general environment In 1994-2003, the median blood Cd levels ranged in the interval 0.9-0.4 microg/l blood, in smokers being more than double that in non-smokers. Blood Cd levels detected indicate slightly decreasing trend as well as urine Cd levels (range of median values 0.44-0.28 microg/g creatinine). Since 1996 the levels in children have been found in more than 50% cases below the detection limit of the methods used. The estimated total cadmium intake in the Czech urban population does not signalize any increased risk of health impairment considering non-carcinogenic effects.

  18. Trends in occupational and collective dose in the Czech Republic

    International Nuclear Information System (INIS)

    Petrova, K.; Prouza, Z.

    1998-01-01

    Recent new legislation in the Czech Republic (Law on Peaceful Use of Nuclear Energy and Ionizing Radiation [2]) is based on the ICRP Report 60 [3] and New International Basic Safety Standards [4]. Concerning the personal monitoring of workers, licensee will be responsible not only to designate controlled areas where specific protective measures are required for control of occupational radiation exposures (ORE) and prevention of the spread of contamination during normal working conditions, but shall also maintain exposure records for each worker for whom assessment of ORE is required. This duty of licensee is given in new Regulation on Radiation Protection No.184 adopted in August 1997 [1]. In accordance with this Regulation one duty of licensee is to send results of personal monitoring to the State Office for Nuclear Safety. The Central Registry of Occupational Exposures (CROE) was regularly established for this purpose in the State Office for Nuclear Safety and rules for handling, maintenance and protection of data were defined. The data collected in CROE were used for the evaluation of trends of occupational exposures in the Czech Republic in the period 1990 - 1994 years also for the UNSCEAR survey. Basic information about the methods used for ORE evaluation, comments for different occupational groups and general conclusions are presented. It is concluded that general trend of the occupational exposures in the Czech Republic is constant with the average value of effective dose equivalent 1.02 mSv (without workers in uranium industry). It is observed the slight increase of exposures in medicine related with the reorganisation on this field and significant decrease in uranium industry related with the suppression of uranium production. (author)

  19. Structural seismic upgrading of NPPs in Czech and Slovak republics

    Energy Technology Data Exchange (ETDEWEB)

    David, M. [DAVID Consulting, Engineering and Design Office, Prague (Czech Republic)

    1997-03-01

    Several Nuclear Power Plants of the VVER type has been constructed during the past years in former Czechoslovak Republic. Some of them has been already put in operation and some of them are under construction. Nuclear Power Plants V1(2 units of VVER 440/230), V2(2 units of VVER 440/213) in Slovak and NPP Dukovany (4 units of VVER 440/213) in Czech republic are in operation. NPP Mochovce (4 units of VVER 440/213) in Slovak and NPP Temelin (4 units reduced now to 2 units VVER 1000) have been already almost completed, but still under construction. All above cited NPPs have not been either explicitly designed against earthquake or the design against earthquake or its input data must be upgraded to be compatible with present requirements. The upgrading of seismic input as well the seismic upgrading of all structures and technological equipments for so many NPPs has involved a lot of comprehensive work in Czech as well as in Slovak republics. The upgrading cannot be completed in a short time and as a rule the seismic upgrading has been usually performed in several steps, beginning with the most important arrangements against seismic hazard. The basic principles and requirements for seismic upgrading has been defined in accordance with the international and particularly with the IAEA recommendations. About the requirements for seismic upgrading of NPPs in Czech and Slovak republics will be reported in other contribution. This contribution is dealing with the problems of seismic upgrading of NNPs civil engineering structures. The aim of this contribution is to point out some specific problems connected firstly with very complicated concept of Versa structures and secondly with the difficult task to increase the structural capacity to the required seismic level. (J.P.N.)

  20. The potential biomass for energy production in the Czech Republic

    International Nuclear Information System (INIS)

    Lewandowski, I.; van Hooijdonk, A.; van Dam, J.; Faaij, A.; Weger, J.; Havlickova, K.

    2006-01-01

    Biomass production is a promising alternative for the Czech Republic's (CZ) agricultural sector. Biomass could cover the domestic bio-energy demand of 250PJa -1 (predicted for 2030), and could be exported as bio-fuels to other EU countries. This study assesses the CZ's biomass production potential on a regional level and provides cost-supply curves for biomass from energy crops and agricultural and forestry residues. Agricultural productivity and the amount of land available for energy crop production are key variables in determining biomass potentials. Six scenarios for 2030 with different crop-yield levels, feed conversion efficiencies and land allocation procedures were built. The demand for food and fodder production was derived from FAO predictions for 2030. Biomass potential in the CZ is mainly determined by the development of food and fodder crop yields because the amount of land available for energy crop production increases with increasing productivity of food and fodder crops. In most scenarios the NUTS-3 regions CZ020, 31 and 32 provided the most land for energy-crop production and the highest biomass potentials. About 110PJa -1 , mostly from agricultural and forestry residues, can be provided from biomass when the present Czech agricultural productivity is maintained. About 195PJa -1 (105PJ from energy crops) can be provided when production systems are optimised with regard to fertilizer regimes and 365PJa -1 (290PJ from energy crops) when the yield level of Dutch agriculture is reached. Costs for woody biomass decrease with increasing plantation yield and range between 2.58 and 4.76 GJ -1 . It was concluded that Czech agriculture could provide enough biomass for domestic demand and for export if agricultural productivity is increased. (author)

  1. Green Investment Scheme: Experience and results in the Czech Republic

    International Nuclear Information System (INIS)

    Karásek, Jiří; Pavlica, Jaroslav

    2016-01-01

    The key goal of this study was to analyse application of the Green Investment Scheme in the Czech Republic through the Green Savings Programme finalising in 2015. The programme was evaluated in terms of aspects of both reduction effectiveness and economic aspects of the basic subsidy categories: (a) Insulation; (b) Low-Energy Houses; (c) Biomass Boilers; (d) Solar Thermal Systems and (e) Heat Pumps. The essential results of the programme were also covered, including the number of projects supported, the total volume of emission reduction and the volume of financial funding. The basic evaluation was based on selected indicators, including abatement costs, greening ratio, payback period and subsidy share of investment costs. The primary data for calculating originated from the database of the Information System of the Green Savings Programme by the State Environmental Fund of the Czech Republic. The calculated value of abatement cost was between 12 (heat pumps and biomass boilers) and 272 € t CO 2 −1 (low-energy houses). The shortest payback time-periods were calculated for insulation at 11.2 and 3.8 years respectively, without and including the provided subsidy. On the contrary, there was no economic payback in the case of biomass boilers, due to transition to an economically costlier fuel. - Highlights: • Unique, thorough study of the Green Investment Scheme in the Czech Republic. • Recommendation on the evaluation parameters of the energy efficiency projects. • Study is a great inspiration for Eastern European and Middle Asian countries. • Instigation to develop similar supporting schemes for energy efficiency and RES-H.

  2. Malacofauna of Selected Protected Landscape Areas in Bohemia (Czech Republic

    Directory of Open Access Journals (Sweden)

    Hlava J.

    2015-06-01

    Full Text Available Molluscan diversity in selected Protected Landscape Areas (PLA of Bohemia (Czech Republic was monitored. For the study, the small-scale PLAs of the Slavkovský Les, the Blanský Les, and the Labské Pískovce were selected. Over 12 500 specimens in total representing 62 mollusc species were found within 2012-2013 by means of hand collecting and sieving the litter layer. To evaluate similarity among the localities, the Jaccard and Sörensen’s indices were calculated. The significance of such data is mainly in their presentation in the available resources such as peer-reviewed scientific journals

  3. Management of Innovation Projects in SMEs in the Czech Republic

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    Miroslav Špaček

    2016-04-01

    Full Text Available There is prevailing understanding that large companies are mostly inclined to using sophisticated innovation management processes as well as other management tools like project portfolio management while SMEs are believed to take advantage of more simple and often intuitive approaches to innovation processes management. Therefore methodologies of Monte Carlo simulation (MC, Stage Gate Control Process (SGCP and Post- -implementation review (PIR were reprocessed into more simplistic implementation models so as to prove that these methods can be operated even by routine staffs in Czech SMEs. All the test performed proved that the applications of aforementioned methods increased the effectiveness of innovation projects management and generated added value for shareholders.

  4. Gender wage differences in the selected Czech public sector company

    OpenAIRE

    Veronika Hedija; Petr Musil

    2012-01-01

    The issue of wage disparity between men and women belongs to the current and widely discussed topics. The attention given to this subject also reflects the fact that the issue of the equality between women and men and non-discrimination by gender is incorporated in the law of the European Union. A number of studies are devoted to the gender wage disparities and the root cause of wage differences in the Czech Republic, however, only few of these deal with the gender wage differentials in the p...

  5. Russian word-formation in contrast with Czech and Norwegian

    Directory of Open Access Journals (Sweden)

    Laura A Janda

    2011-02-01

    Full Text Available Although some scholarship on metonymy has mentioned examples of word-formation and some scholarship on word-formation has mentioned the presence of metonymy, to date there has been no attempt to examine the systematic role of metonymy in the domain of word-formation. This article presents an empirical study of the metonymies signalled by derivational suffixes in Russian, Czech and Norwegian. This approach facilitates cross-linguistic comparison that reveals significant differences among languages, and these differences appear relevant to cultural differences.

  6. Modification and application of ECSI on the Czech service market

    Directory of Open Access Journals (Sweden)

    Kateřina Ryglová

    2005-01-01

    Full Text Available Considering contemporary trends in development of the world’s economy, all kinds of companies are made to analyse and implement new access to firm’s strategies. This article deals with new trends in marketing analysis focused on measurement and evaluation of customer satisfaction. We tried to apply methodology of ECSI (European customer satisfaction index into Czech service market. We counted the total customer satisfaction indexes for two chosen travel agencies (85% for the first travel agency, and 74% for the second one and for two chosen banks (72% for the first bank, and 82% for the second one.

  7. Marketing Strategy of YouTube in the Czech Republic

    OpenAIRE

    Hurychová, Andrea

    2012-01-01

    The goals of the thesis are to present YouTube in the Czech Republic, to discuss its entire business model, analyze the main local competitors and mostly to suggest marketing strategy that will strengthen the position of YouTube as an online medium. The current trends in the internet society are introduced as well as the role of social media in order to understand how these factors are related to the position of YouTube in marketing. From general YouTube introduction the situation of this pla...

  8. The mercury burden of the Czech population: An integrated approach.

    Science.gov (United States)

    Puklová, Vladimíra; Krsková, Andrea; Cerná, Milena; Cejchanová, Mája; Rehůrková, Irena; Ruprich, Jirí; Kratzer, Karel; Kubínová, Růzena; Zimová, Magdaléna

    2010-07-01

    In this paper an integrated approach in assessment of the population exposure from various sources of total mercury (THg) oral intake in the Czech Republic is presented. The information on total mercury levels in diet, drinking water, surface urban soil and body fluids and tissues stem from the Czech national Environmental Health Monitoring System (EHMS) operated since 1994. The THg concentration was determined by the special atomic absorption spectrophotometer AMA 254. The data on THg content in food from the sales network were collected in 12 cities. The estimated average dietary intake representing more than 95% of weight of usual diet composition ranged 1-2% of the JECFA/FAO WHO provisional tolerable weekly intake (PTWI) value for total mercury (5 microg/kg b.w./week). Data on drinking water quality stem from the nationwide monitoring database. The content of THg in drinking water is generally low; only 0.2% of the Czech population supplied with drinking water from the distribution networks (total of 92% of the population) has a mercury intake from drinking water higher than 1% PTWI and not exceeding 5% PTWI. The estimation of potential mercury intake by unintentional consumption of soil in small children was based on THg content in surface soil of a total of 324 nursery schools in 24 cities and towns. Median value was 0.16 mg/kg. Human biomonitoring was performed in 9 Czech cities. In 2007, the mercury median values in blood of adults (N=412) were 0.85 and 0.89 microg/l in males and in females, respectively; urine median value in adults was 1.10 microg/g creatinine. In 2008, the blood median value in children (N=324) amounted to 0.35 microg/l; urine median value is 0.16 microg/g creatinine. In children's hair the median THg value was 0.18 microg/g. The correlation between fish consumption and blood THg levels was observed in both adults and children. Also the biomonitoring outputs did not reveal a substantial burden of the population. Copyright 2010 Elsevier

  9. [Prenatal diagnostics of chromosomal aberrations Czech Republic: 1994-2007].

    Science.gov (United States)

    Gregor, V; Sípek, A; Sípek, A; Horácek, J '; Langhammer, P; Petrzílková, L; Calda, P

    2009-02-01

    An analysis of prenatal diagnostics efficiency of selected types of chromosomal aberrations in the Czech Republic in 2007. Update of 1994-2007 data according to particular selected diagnoses. Retrospective epidemiological analysis of pre- and postnatal chromosomal aberrations diagnostics and its efficiency. Data on pre- and postnatally diagnosed birth defects in the Czech Republic during 1994-2007 were used. Data on prenatally diagnosed birth defects (and for terminated pregnancies) were collected from particular departments of prenatal diagnostics, medical genetics and ultrasound diagnostics in the Czech Republic, data on birth defects in births from the National Birth Defects Register (Institute for Health Information and Statistics). Total numbers over the period under the study, mean incidences of selected types of chromosomal aberrations and mean prenatal diagnostics efficiencies were analyzed. Following chromosomal aberrations were studied: Down, Edwards, Patau, Turner and Klinefelter syndromes and syndromes 47,XXX and 47,XYY. A relative proportion of Down, Edwards and Patau syndromes as well as other autosomal and gonosomal aberration is presented in figures. Recently, trisomies 13, 18 and 21 present around 70% of all chromosomal aberrations in selectively aborted fetuses, in other pregnancies, "other chromosomal aberrations" category (mostly balanced reciprocal translocations and inversions) present more than 2/3 of all diagnoses. During the period under the study, following total numbers, mean relative incidences (per 10,000 live births, in brackets) and mean prenatal diagnostics efficiency (in %) were found in following chromosomal syndromes: Down syndrome 2,244 (16.58) and 63.37%, Edwards syndrome 521 (3.85) and 79.93%, Patau syndrome 201 (1.49) and 68.87%, Turner syndrome 380 (2.81) and 79.89%, 47,XXX syndrome 61 (0.45) and 59.74%, Klinefelter syndrome 163 (1.20) and 73.65% and 47,XYY syndrome 22 (0.16) and 54.76%. The study gives updated results of

  10. Medical decision support and medical informatics education: roots, methods and applications in czechoslovakia and the czech republic.

    Science.gov (United States)

    Zvárová, Jana

    2013-01-01

    The paper describes the history of medical informatics in Czechoslovakia and the Czech Republic. It focuses on the topics of medical informatics education and decision support methods and systems. Several conferences held in Czechoslovakia and in the Czech Republic organized in cooperation with IMIA or EFMI are described. Support of European Union and Czech agencies in several European and national projects focused on medical informatics topics highly contributed to medical informatics development in Czechoslovakia and the Czech Republic and to the establishment of the European Center for Medical Informatics, Statistics and Epidemiology as the joint workplace of Charles University in Prague and Academy of Sciences of the Czech Republic in 1994.

  11. Evaluation of the assessment and documentation of chronic wounds in residential social care in the Czech Republic.

    Science.gov (United States)

    Saibertová, S; Pokorná, A

    2016-11-02

    Accurate evaluation of non-healing, chronic wounds followed by the selection of an appropriate therapeutic strategy is a must for the foundation of health-care management. Assessment of non-healing chronic wounds in clinical practice in the Czech Republic is not standardised in acute care settings or in residential social care facilities. The aim of the study was to analyse the methods being used to assess non-healing, chronic wounds in residential social services in the Czech Republic, where more patients with chronic wounds are present because of the increasing incidence of wounds in old age. The research was carried out at 66 residential social care institutions across all regions of the Czech Republic. A mixed model was used for the research (participatory observation including creation of field notes and content analysis of documents for documentation and analysis of qualitative and quantitative data). The same methodology was used in previous work which has been done in acute care settings in 2013. The results of this research have corroborated the inconsistencies in procedures used by general nurses for assessment of non-healing, chronic wounds. However, the situation was found to be more positive with regard to the evaluation of basic/fundamental parameters of a wound (e.g. size, depth and location of the wound) compared with the evaluation of more specific parameters (e.g. exudate or signs of infection). This included not only the number of observed variables, but also the action taken. Both were improved when a consultant for wound healing was present. An effective strategy for wound management depends on the method and scope of the assessment of non-healing, chronic wounds in place in clinical practice in observed facilities; improvement may be expected following the general introduction of 'non-healing, chronic wound assessment' algorithm.

  12. HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population.

    Science.gov (United States)

    Fojtíková, Markéta; Novota, Peter; Cejková, Pavlína; Pešičková, Satu; Tegzová, Dana; Cerná, Marie

    2011-09-01

    The genetic components contribute to the systemic lupus erythematosus development. This study for the first time determined the distribution of the polymorphisms and linkage disequilibrium in HLA class II, MICA and PRL gene among patients suffering from SLE and healthy Czech individuals. DNA was obtained from the peripheral blood cells of 123 SLE patients and 96 healthy people. Allele variants of the HLA class II, MICA transmembrane polymorphism and PRL extrapituitary promoter -1149G/T SNP were detected using the sequence-specific primers analysis, PCR-fragment analysis and PCR-RFLP, respectively. In Czech population, only DRB1*03-DQB1*0201 haplotype is significantly associated with increased risk for SLE development: the frequency in SLE group was 44.7% in comparison with 15.2% in controls, P (c) absence both alleles MICA-A6 and HLA DRB*11 seems to be risk for SLE development compared to controls, 84.6 and 70.2%, respectively, [P (c) = 0.0003 OR 2.32 CI 95% (1.47-3.70)]. We found that only G allele of the -1149 G/T SNP is associated with specific clinical manifestation of SLE, arthritis [P (c) = 0.022; OR 2.63, CI 95% (1.45-4.81)]. HLA class II-MICA combinations may increase/decrease a risk for SLE development. Multiple studies focusing on the ethnical differences as well as genetic-epigenetic relationships are necessary for better understanding SLE pathogenesis.

  13. The BNCT project in the Czech Republic

    International Nuclear Information System (INIS)

    Burian, J.; Marek, M.; Rataj, J.; Honova, H.; Petruzelka, L.; Prokes, K.; Tovarys, F.; Dbaly, V.; Honzatko, J.; Tomandl, I.

    2000-01-01

    The start of clinical trials is expected before NCT Osaka 2000. The experiences from different part of project are presented. The BNCT facility at LVR-15 reactor of NRI consists of epithermal neutron beam with improved construction (6.98 x 10 8 /cm 2 s with acceptable background of fast neutrons and gammas) and irradiation and control rooms equipped by appropriate devices. Internationally-recognized software MacNCTPLAN is utilized for computational dosimetry and treatment planning. In the part of protocol the following parameters have been assessed: patient selection, BSH dosage, fractionation, starting dose, dose escalation steps. At the LVR-15, at horizontal channel, a prompt gamma ray analysis (PGRA) system has been developed and is operated for BNCT purposes. Some human blood samples were analyzed and compared with classical ICP method. During the process of licensing the experience was obtained, some notes are discussed in the paper. The first results were received for the study of biological effect of the LVR source for small animal model. (author)

  14. Analysis of innovation activity of Slovak and Czech enterprises

    Directory of Open Access Journals (Sweden)

    Emília Spišáková

    2011-04-01

    Full Text Available European innovation scoreboard is used to monitor and compare the innovation performance of European countries, according to which was the Slovak Republic, together with two other V4 countries, i.e. Hungary and Poland, at the time of last available data from this area, classified into the last, fourth group of countries named “catching-up countries”. These countries were characterized by the lack of innovation activity, which was well below the EU 27 average. From the V4 countries, Czech Republic achieved the best results, belongs to “moderate innovators” and is the most close to the European average. At a present time all four countries are included in a group of moderate innovators. The innovation performance of whole country is particularly influenced by innovation activities of enterprises operating in this country. For this reason, the article deals with the detailed analysis of innovative activity of enterprises by their size and sector of their operation in Czech and Slovak Republic, and also deals with the cooperation of enterprises in these activities in terms of the type of partner and the countries of their interaction.

  15. Behaviour of Czech customers when buying food products

    Directory of Open Access Journals (Sweden)

    Halina Starzyczná

    2013-01-01

    Full Text Available This paper presents partial results of the primary research conducted through a questionnaire survey focused on the behaviour of Czech consumers when buying food, with regard to the behaviour of men and women. Specific objectives included are a brief outline of the theoretical issues examined and secondary research on the buying behaviour of consumers when buying food, based on available statistical data and information. After 1989, the quality of the market has changed, sales space has increased as well as the level of sales conditions. Offer in stores has widened. Recently the results of inspections of supervisory authorities show a lot of negative information, mainly relating to foreign chains. The supply of poor quality food is more common. Some food is offered even though it’s expired. The proposed premises are based on the current situation in the Czech retail market. Despite increased consumer awareness about the quality of food, the majority of respondents buy food in large commercial units (supermarket, hypermarket, discounts. The majority of respondents do not follow information on the packaging of food products, but follow the expiration date. Sales of food with expired shelf life or expiration date re-taped is usually notified by the supervisory authorities, therefore, is noticed by consumers. Buying behaviour of men and women shows some differences. Our results, however, have not proved any significant ones, although a small difference has emerged.

  16. Gender wage differences in the selected Czech public sector company

    Directory of Open Access Journals (Sweden)

    Veronika Hedija

    2012-01-01

    Full Text Available The issue of wage disparity between men and women belongs to the current and widely discussed topics. The attention given to this subject also reflects the fact that the issue of the equality between women and men and non-discrimination by gender is incorporated in the law of the European Union. A number of studies are devoted to the gender wage disparities and the root cause of wage differences in the Czech Republic, however, only few of these deal with the gender wage differentials in the public sector. It is exactly this issue, which is discussed in this article, its aim being to identify the extent of the gender pay gap in the selected Czech public sector company. The article concentrates on finding the main causes for the existence of wage differences between men and women and determining whether the company inclines to wage discrimination against women. The Oaxaca-Blinder decomposition is used to define, which part of the gender pay gap can be attributed to the different characteristics of men and women and which part stays unexplained. It is this unexplained part that can be the result of wage discrimination against women.

  17. The Key Issues of Labor Migration in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Marie JELINKOVA

    2007-04-01

    Full Text Available This paper aims to highlight some often occurring failures that need to be eliminated when attempting to develop an integral and efficient policy on labor migration. As an example, a brief overview of the development of immigration policies and its critical shortcomings in the Czech Republic is provided. Following this, the paper analyzes two aspects: the protection of migrant workers and the trafficking in human beings. In particular, the paper deals with three crucial issues of labor migration which are: (1 the inconsistent aims of immigration policies, (2 the client system, and (3 the dependence on middlemen. The paper also focuses on the role of state, police, and NGO’s in the trafficking in human beings and forced labor or labor exploitation in the Czech Republic. In addition, the legislation on forced labor and the possibilities of assistance to trafficked person are analyzed.By comparing various aspects of immigration policy, this paper covers some, but certainly not all, of the key issues concerning the process of immigrant integration. Several suggestions are made that could improve the situation of labor migrants in a significant way.

  18. Features of the Regional Labor Markets in the Czech Republic

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    Vít Pošta

    2017-06-01

    Full Text Available We use the Labor Office data for the regions of the Czech Republic to investigate some of the structural features of the respective labor markets. We build our approach on the matching function of the search model of the labor market. In the paper we show how the regional labor markets differ with respect to vacancies, unemployment, matches between unemployed and vacancies, probability of finding a job and labor market tightness. We also demonstrate how these characteristics evolved over time. We show that the labor markets were really hit the hardest several years after the great recession began to affect the Czech Republic. We go on to estimate the matching function for the respective regional labor markets and show that the sensitivity of the probability of finding a job to the labor market tightness generally increased over time, which we interpret as a positive sign. We set our results in the framework of some of the earlier work which has been done. With all the data and estimates used we are able to pinpoint the most troubled regions as far as the structural features of the labor market are concerned.

  19. Czech Public and Occupational Pension Schemes and Reforms

    Directory of Open Access Journals (Sweden)

    VOSTATEK, Jaroslav

    2017-08-01

    Full Text Available The Czechoslovak communist retirement protection scheme resembled the Bismarckian earnings-related pensions, with new benefits close to final salaries and with their insufficient indexation. The aim of this paper is to evaluate the reform processes in Czechia and the potential for a simple technical reform that would make the public retirement schemes understandable and efficient. In the process of the transition to capitalism under liberal Czech governments, the prevailing concept of the public retirement scheme changed to a Beveridge model of pensions not being related to previous wages. The insufficient valorisation of bend points was the main method of this transition. Modern international pension theory recommends the separation of a solidary pillar and an earnings-related pillar. After the Czech “small” pension reform, a basic technical reform may be simply realised, resulting in a higher flat-rate pension and an NDC pension insurance scheme, convenient to parties with programmes based on three basic welfare regimes. The introduction of occupational pension schemes is necessary to reflect the specifics of arduous occupations.

  20. Factors Influencing Age Management in Organisations in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Hana Urbancová

    2017-02-01

    Full Text Available This paper deals with the topical issues of age management and population ageing in the Czech Republic and Europe. The main objective of the paper is to evaluate the importance of individual visions of age management according to Ilmarinen (2006 and Cimbálníková et al. (2012 in organisations in the Czech Republic and to identify factors that influence the implementation of individual visions in the organisation. The primary data (n = 549 was collected by means of a questionnaire technique. The research results have shown that the most important visions are as follows: (1 a fair attitude towards age, (2 knowledge about age issues and (3 a happy life and motivation. In order to evaluate the implementation of age management visions, a factor analysis was performed, on the basis of which two significant factors were identified: (1 organisational culture and (2 job performance and relationships. Based on the research results, organisations are recommended to focus on continuous analysis of their organisational culture, to adapt to changes in their environment, also to implement an effective employee performance appraisal system, and to explore the development of employees and relationships among generations of employees with emphasis on eliminating ageism.