WorldWideScience

Sample records for custom designed plaque

  1. Involving Customer Relations in Contextual Design

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    1996-01-01

    This paper presents a case study in the form of a contextual design project, the aim of which was to design a system for a particular organization. The starting point in the case was a need in the organization for a specific system. The case involved an analysis of the organizations customer...... point of the design project, how the project was conducted, and which results it ended up with. This is followed by a discussion of the effects of, and lessons learned by, involving customer relations in contextual design....

  2. Contextual design defining customer-centered systems

    CERN Document Server

    Beyer, Hugh

    1997-01-01

    This book introduces a customer-centered approach to business by showing how data gathered from people while they work can drive the definition of a product or process while supporting the needs of teams and their organizations. This is a practical, hands-on guide for anyone trying to design systems that reflect the way customers want to do their work. The authors developed Contextual Design, the method discussed here, through their work with teams struggling to design products and internal systems. In this book, you'll find the underlying principles of the method and how to apply them to diff

  3. Advanced customization in architectural design and construction

    CERN Document Server

    Naboni, Roberto

    2015-01-01

    This book presents the state of the art in advanced customization within the sector of architectural design and construction, explaining important new technologies that are boosting design, product and process innovation and identifying the challenges to be confronted as we move toward a mass customization construction industry. Advanced machinery and software integration are discussed, as well as an overview of the manufacturing techniques offered through digital methods that are acquiring particular significance within the field of digital architecture. CNC machining, Robotic Fabrication, and Additive Manufacturing processes are all clearly explained, highlighting their ability to produce personalized architectural forms and unique construction components. Cutting-edge case studies in digitally fabricated architectural realizations are described and, looking towards the future, a new model of 100% customized architecture for design and construction is presented. The book is an excellent guide to the profoun...

  4. DESIGN ATTRIBUTES OPTIMIZATION MODEL FOR CUSTOMIZED PRODUCT AND ITS APPLICATION

    Institute of Scientific and Technical Information of China (English)

    Cao Le; Liu Fei; Lei Qi

    2005-01-01

    By formulating the design of customized product as a multi-objective optimization problem,a method for designing customized product according to the relative importance of customer needs is proposed. This method searches for the optimal design that maximizes customer satisfaction by establishing mapping from design attributes to the degree of customer satisfaction on each customer need.A window product is taken as an example for case study. The result indicates that this method is feasible.

  5. Design of Customer Satisfaction Measurement Index System of EMS Service

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This paper discusses the design of a customer satisfaction measurement index system of erpress mail service. It presents objectives and principles of the design based on hierarchical structures. We have devised a diagram for modeling customer satisfaction, and a detailed analysis of customer satisfaction is conducted. This paper presents our customer satisfaction model and analysis results.

  6. Design of Customized Corporate E-Learning

    Directory of Open Access Journals (Sweden)

    Tor Atle Hjeltnes

    2009-10-01

    Full Text Available Today's educational institutions deal increasingly with external commercial organizations in connection with e-learning deliveries. Production and delivery of e-learning to corporations is different from both traditional campus education and online distance education for independent online students. This study discusses challenges related to e-learning production and delivery for corporate customers. Consequently we have identified appropriate guiding principles that should contribute to the specification of amodel for design of customized corporate e-learning. We place particular emphasis on collaboration and stakeholder involvement, formative evaluation, utilization of technological opportunities, and relevant training for all parties involved. Moreover, we propose to benefit from concurrent design principles to achieve effective and efficient multidisciplinary collaboration in the design process. The study is based on primary data from two different projects where an educational institution offers e-learning for external corporate customers. In addition we collect secondary data from available research literature on e-learning and supplementary data from colleagues with long experience in this field.

  7. A semi-custom design methodology for design performance optimization

    Institute of Scientific and Technical Information of China (English)

    Dong-ming LV; Pei-yong ZHANG; Dan-dan ZHENG; Xiao-lang YAN; Bo ZHANG; Li QUAN

    2008-01-01

    We present a semi-custom design methodology based on transistor tuning to optimize the design performance.Compared with other transistor tuning approaches, our tuning process takes the cross-talk effect into account and prominently reduces the complexity for circuit simulation and analysis by decomposing the circuit network utilizing graph theory. Furthermore,the incremental placement and routing for the corresponding transistor tuning in conventional approaches is not required in our methodology, which might induce timing graph variation and additional iterations for design convergence. This methodology combines the flexible automated circuit tuning and physical design tools to provide more opportunities for design optimization throughout the design cycle.

  8. Study on Design Methodology of Mass Customization Products

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Based on introduction characteristics and classific at ion of Mass Customization (MC), the paper expounds foundations and design me thods of MC. The foundations of MC production are standardization, seriation and normality of production, guiding thought of Concurrent Engineering (CE), ap plication of CAD/CAM technology and etc. And design methods of MC products are d esign for product family, modular design, parameterization CAD, variant design, design for manufacturing (DFM) and design by customers. ...

  9. Development of Interactive Industrial Design Support System Considering Customer's Evaluation

    Science.gov (United States)

    Yanagisawa, Hideyoshi; Fukuda, Shuichi

    To respond to rapidly changing and diversifying customers' requirements, an industrial design support system for eyeglass frames which allows the customer to participate in the industrial design process was developed. This system is based on the Interactive Evolutionary Computing (IEC) technique so that a customer can interact with the system to express his or her Kansei requirements through images. The design of an eyeglass frame cannot be determined in isolation but rather must be determined by considering its appearance on the customer. In the developed system, the user evaluates each sample suggested by the system and narrows down the candidate gradually. Its usefulness was demonstrated by operational experiments and questionnaires.

  10. Design to learn: customizing services when the future matters

    Directory of Open Access Journals (Sweden)

    Dan Ariely

    2013-04-01

    Full Text Available Internet-based customization tools can be used to design service encounters that maximize customers' utility in the present or explore their tastes to provide more value in the future, where these two goals conflict with each other. Maximizing expected customer satisfaction in the present leads to slow rates of learning that may limit the ability to provide quality in the future. An emphasis on learning can lead to unsatisfied customers that will not only forego purchasing in the current period, but, more seriously, never return if they lose trust in the service provider's ability to meet their needs. This paper describes service design policies that balance the objectives of learning and selling by characterizing customer lifetime value as a function of knowledge. The analysis of the customization problem as a dynamic program yields three results. The first result is the characterization of customization policies that quantify the value of knowledge so as to adequately balance the expected revenue of present and future interactions. The second result is an analysis of the impact of operational decisions on loyalty, learning, and profitability over time. Finally, the quantification of the value of knowing the customer provides a connection between customer acquisition and retention policies, thus enhancing the current understanding of the mechanisms connecting service customization, value creation, and customer lifetime value.

  11. Transforming Multidisciplinary Customer Requirements to Product Design Specifications

    Science.gov (United States)

    Ma, Xiao-Jie; Ding, Guo-Fu; Qin, Sheng-Feng; Li, Rong; Yan, Kai-Yin; Xiao, Shou-Ne; Yang, Guang-Wu

    2017-09-01

    With the increasing of complexity of complex mechatronic products, it is necessary to involve multidisciplinary design teams, thus, the traditional customer requirements modeling for a single discipline team becomes difficult to be applied in a multidisciplinary team and project since team members with various disciplinary backgrounds may have different interpretations of the customers' requirements. A new synthesized multidisciplinary customer requirements modeling method is provided for obtaining and describing the common understanding of customer requirements (CRs) and more importantly transferring them into a detailed and accurate product design specifications (PDS) to interact with different team members effectively. A case study of designing a high speed train verifies the rationality and feasibility of the proposed multidisciplinary requirement modeling method for complex mechatronic product development. This proposed research offersthe instruction to realize the customer-driven personalized customization of complex mechatronic product.

  12. The Expert System Designed to Improve Customer Satisfaction

    CERN Document Server

    Devi, P Isakki alias

    2011-01-01

    Customer Relationship Management becomes a leading business strategy in highly competitive business environment. It aims to enhance the performance of the businesses by improving the customer satisfaction and loyalty. The objective of this paper is to improve customer satisfaction on product's colors and design with the help of the expert system developed by using Artificial Neural Networks. The expert system's role is to capture the knowledge of the experts and the data from the customer requirements, and then, process the collected data and form the appropriate rules for choosing product's colors and design. In order to identify the hidden pattern of the customer's needs, the Artificial Neural Networks technique has been applied to classify the colors and design based upon a list of selected information. Moreover, the expert system has the capability to make decisions in ranking the scores of the colors and design presented in the selection. In addition, the expert system has been validated with a different...

  13. Innovative Product Design Based on Customer Requirement Weight Calculation Model

    Institute of Scientific and Technical Information of China (English)

    Chen-Guang Guo; Yong-Xian Liu; Shou-Ming Hou; Wei Wang

    2010-01-01

    In the processes of product innovation and design, it is important for the designers to find and capture customer's focus through customer requirement weight calculation and ranking. Based on the fuzzy set theory and Euclidean space distance, this paper puts forward a method for customer requirement weight calculation called Euclidean space distances weighting ranking method. This method is used in the fuzzy analytic hierarchy process that satisfies the additive consistent fuzzy matrix. A model for the weight calculation steps is constructed;meanwhile, a product innovation design module on the basis of the customer requirement weight calculation model is developed. Finally, combined with the instance of titanium sponge production, the customer requirement weight calculation model is validated. By the innovation design module, the structure of the titanium sponge reactor has been improved and made innovative.

  14. DESIGN OF 3D MODEL OF CUSTOMIZED ANATOMICALLY ADJUSTED IMPLANTS

    OpenAIRE

    Miodrag Manić; Zoran Stamenković; Milorad Mitković; Miloš Stojković; Duncan E.T. Shephard

    2015-01-01

    Design and manufacturing of customized implants is a field that has been rapidly developing in recent years. This paper presents an originally developed method for designing a 3D model of customized anatomically adjusted implants. The method is based upon a CT scan of a bone fracture. A CT scan is used to generate a 3D bone model and a fracture model. Using these scans, an indicated location for placing the implant is recognized and the design of a 3D model of customized implants is made. Wit...

  15. Custom-made Microdialysis Probe Design.

    Science.gov (United States)

    Lietsche, Jana; Gorka, Jan; Hardt, Stefanie; Karas, Michael; Klein, Jochen

    2015-07-21

    Microdialysis is a commonly used technique in neuroscience research. Therefore commercial probes are in great demand to monitor physiological, pharmacological and pathological changes in cerebrospinal fluid. Unfortunately, commercial probes are expensive for research groups in public institutions. In this work, a probe assembly is explained in detail to build a reliable, concentric, custom-made microdialysis probe for less than $10. The microdialysis probe consists of a polysulfone membrane with a molecular cut-off of 30 kDa. Probe in vitro recoveries of substances with different molecular weight (in the range of 100-1,600 Da) and different physicochemical properties are compared. The probe yields an in vitro recovery of approximately 20% for the small compounds glucose, lactate, acetylcholine and ATP. In vitro recoveries for neuropeptides with a molecular weight between 1,000-1,600 Da amount to 2-6%. Thus, while the higher molecular weight of the neuropeptides lowered in vitro recovery values, dialysis of compounds in the lower range (up to 500 Da) of molecular weights has no great impact on the in vitro recovery rate. The present method allows utilization of a dialysis membrane with other cut-off value and membrane material. Therefore, this custom-made probe assembly has the advantage of sufficient flexibility to dialyze substances in a broad molecular weight range. Here, we introduce a microdialysis probe with an exchange length of 2 mm, which is applicable for microdialysis in mouse and rat brain regions. However, dimensions of the probe can easily be adapted for larger exchange lengths to be used in larger animals.

  16. Research on integrating customization design for mechanical product

    Institute of Scientific and Technical Information of China (English)

    TAI Ligang; LI Dianqi; ZHONG Tingxiu; LI Zhi

    2007-01-01

    This paper proposes an integrating rapid custom- ization design system which combines various technologies such as Web, knowledge based engineering (KBE), engineer- hag database and Computer Aided Design (CAD) and has been used in elevator design. The whole system is set up on the base of engineering database technology, integrating Product Data Management (PDM), Enterprise Resource Planning (ERP) etc. It adopts Web technology to enable cus- tomers to individually customize products remotely through the internet. The system also adopts KBE to manage and reuse product design knowledge, while combining the tech- nology of product family modeling and technologies of feature modeling and parametric design, based on the assem- bly of the CAD system of Unigraphics Solutions Inc., to create a product family case library that achieves intelligent, rapid design customization.

  17. Designing and implementing customer-focused functional support teams

    Energy Technology Data Exchange (ETDEWEB)

    Levine, L.O.; Cejka, C.L.

    1995-02-01

    The contract services department of a U.S. Department of Energy research laboratory is radically revising how it serves its primary customers--the laboratory research and development staff. The department provides services that include contract research initiation (proposal preparation and contract negotiation) and acquisition of goods and services to support specific research projects. It previously provided these services with approximately 170 staff in four centralized functional units. In reorganizing, the department used a structured analysis and design process to categorize internal customers according to their unique attributes and specific support needs. Concurrently, it identified a number of conceptually distinct customer-focused units that could accomplish the contract processes in different ways and then chose a preferred concept for each customer category. The organizational concepts were designed to enhance customer service and improve staff morale and development opportunities. The new organization will have a total of 10 customer support units as well as other centralized services and activities. It will flatten the organizational structures and encourage more cooperation among contracts staff to meet customer needs for improved timeliness, communication, and teaming with researchers.

  18. Best practices selection to design for mass customization

    Directory of Open Access Journals (Sweden)

    Diego Castro Fettermann

    2017-03-01

    Full Text Available The use of the best practice in New Product development process (PDP is an alternative to promote Mass Customization (MC strategy in the companies. This paper proposes a decision support system to identify the best practices for designing product features. The decision support system is applied in the service counters design project of a retail company. The results indicate the ability of the decision support system to select MC product design best practices according to the project design features and the project customization level.

  19. Using statistical design experiment methodologies to identify customers' needs

    OpenAIRE

    Huertas Garcia, Rubén; Consolación Segura, Carolina María

    2009-01-01

    Customer satisfaction has become one of the main objectives in all areas of business, especially the tourist trade. One of the most difficult problems is to know how to obtain this satisfaction, which involves identifying customers' needs and desires, and transferring them to our product or service specifications. In order to ascertain the consumer voice, we can ask consumers directly, or thy to deduce their requirements by indirect methods. Statistical design of experiments (SDE) is consider...

  20. Utilizing Mass Customization Methods for Modular Manufacturing System Design

    DEFF Research Database (Denmark)

    Jørgensen, Steffen; Jacobsen, Alexia; Nielsen, Kjeld

    2011-01-01

    of Mass Customization (MC). Research focus has been on the basic principles and enabling technologies, while modular architectures and system design have received less attention. A potential to fill these gaps by applying selected design theories and methods of MC have been seen. Based on a communality...

  1. Strategic Design Factors for an Automated Customer Interface

    Directory of Open Access Journals (Sweden)

    Kristian B. Bader

    2014-09-01

    Full Text Available A substantial review of the extant literature, which is not included in the paper, identifies three agents that influence automation of the customer interface in insurance companies. They are (1 intensified competition mainly resulting from deregulation of general insurance markets, (2 changes in the customer base (tendency to individualisation, request for more flexible products, and (3 technological development, in particular the increasingly intensive use of information and communication technologies for business purposes. Despite these new market influences, even today many insurance companies do not consider automating their processes at the customer front end. Critical thinking and awareness of the influencing factors that surround decisions on automating service delivery processes are not on the managers’ agenda. Further, it is not especially clear what the criteria are that influence automation of the customer interface in insurance companies. With this in mind a qualitative empirical study, conducted by interviewing experts from a sample of Swiss insurance companies that was representative of the structure of competition in the Swiss insurance market, was undertaken. The relevant question asked was, "What are the critical success factors that enable the automation of the customer interface in insurance companies?”.An outcome of the study is a list of eight topics, namely (A Market forces, (B Strategic focus, (C Company-customer-interaction process, (D Suitability of products, (E Multi-channel service delivery, (F Customer segmentation, (G Business case, and (H Technological aspects, that include a total of twenty one design factors considered important when designing an automated customer interface. Discussions centred on these topics and these design factors provided answers to six key questions that facilitated the development of an appropriate managerial model. The study shows that various criteria from many topics are relevant

  2. BT's adoption of customer centric design.

    Science.gov (United States)

    Chamberlain, Mark; Esquivel, Jacqueline; Miller, Fiona; Patmore, Jeff

    2015-01-01

    Between 2005 and 2010 BT underwent a major transformation from a company with a special section devoted to 'older and disabled consumers' to a company with an inclusive design strategy. The mainstreaming of these issues responded to a demand for better, more user-friendly communications products and growing awareness of the importance of previously marginalised consumer groups. It also took place alongside the development and publication of BS7000-6, a guide to inclusive design management. Based on several product design case studies, this paper reflects on how and why this transformation was seen as necessary for future success, and how the transformation was achieved. The evolution of BT's approach has continued since, but this paper looks back in time, and documents the transformation up to 2010 and reflects the state of the company in 2010 rather than at the time of publication.

  3. Designing Usability in a Customer Relationship Management System

    OpenAIRE

    Steinrud, Anders

    2012-01-01

    The need for Customer  Relationship Management (CRM) systems are born from the need of a good overview of the company's customer interactions, but how do you produce a system design of an easy to use and usable environment from scratch without knowing what is out there and with only two potential users at hand? With an iterative approach of evaluating every answer from a few basic, open ended questions and the use of paper prototypes the system was gradually designed from the needs and wants ...

  4. Hybrid customer requirements rating method for customer-oriented product design using QFD

    Institute of Scientific and Technical Information of China (English)

    Fang Wang; Hua Li; Aijun Liu; Xiao Zhang

    2015-01-01

    Quality function deployment (QFD) is a wel-known customer-oriented product design methodology. Rating the final importance of customer requirements (CRs) is real y a very es-sential starting point in the implementation of QFD, since it largely affects the target setting value of design requirements. This pa-per aims to propose a novel method to deal with the relative importance ratings (RIRs) of CRs problem considering customers’ diversified requirements and unknown information on customers’ weights, which is an indispensable process for determining the final importance ratings of CRs. First, a new concept of customer’s assessment structure is proposed according to the basic idea of grey relational analysis (GRA), and then a constrained nonlinear optimization model is constructed to describe the assessment information aggregation factors of CRs considering customers’ personalized and diversified requirements. Furthermore, an im-mune particle swarm optimization (IPSO) algorithm is designed to solve the model, and the weight vector of customers is obtained. Final y, a car door design example is introduced to il ustrate the novel hybrid GRA-IPSO method’s potential application in deter-mining the RIRs of CRs.

  5. METHODS FOR MEASURING CUSTOMER SATISFACTION IN THE DESIGN PROCESS

    Directory of Open Access Journals (Sweden)

    Mirko Đapic

    2007-09-01

    Full Text Available In the design process, the designer makes decisions under uncertainty, contradiction and ignorance conditions. Are these decisions correct and to what extent? How much do they influence customer's satisfaction? These are only some of the questions the designers face all time. These dilemmas appear more in early phases of the design process. The explicit objectives of this paper is improvement of design decision making process in such a way that in same time when designer made a decision he or she show result that decision on customer satisfaction. In order to solve above problems, the paper describes the method, which enables integrated use of the axiomatic approach to designing, and the Taguchi method of robust design. This approach implies the modelling of the development process as an evidence-reasoning network based on uncertain evidence described via belief functions of (Dempster - Shafer theory. The paper starts with base concept of belief functions and valuation based system or evidential reasoning system for representation and reasoning based on uncertainty. After that we introduce coefficient of relative decrease of uncertainty in design process and new graphical representation of system architecture - the evidence networks. On the end we presents a method for measuring customer satisfaction in the design process in uncertainty condition using evidence networks.

  6. Digital geometry processing applied in customized medical implant design.

    Science.gov (United States)

    Xiao-Feng, Zhu; Cheng-Tao, Wang

    2005-01-01

    Standard medical implants are used in most implantation cases, but in some special cases, only those implants conforming to individual patient's skeletal morphology can serve the purpose. This paper proposes a new approach to design and fabricate customized exact-fit medical implants. With a real surgical case as the example, technical design details are presented; and two algorithms are given respectively for segmentation based on object features and triangular mesh defragmentation.

  7. Pedagogical design for knowledge creating inquiry in customer projects

    Directory of Open Access Journals (Sweden)

    Hanni Muukkonen

    2013-09-01

    Full Text Available Two higher education courses involving students, teachers, and customers in multifaceted experiences of knowledge creation are described. The Trialogical Learning Approach (TLA provides a theoretical framework to address learning and teaching organized around authentic problems and the development of shared knowledge objects, such as reports, products, and new practices. The approach directs attention to those aspects of social interaction and artifact-mediated activities, which focus on the development of shared objects and the pursuit of novel knowledge and understanding. The roles of technology-mediation, customer involvement, and guidance in developing effective pedagogical practices for knowledge creation were addressed. It appears necessary to design sufficient open-endedness and complexity for students’ teamwork to generate unpredictable, practical, and epistemologically challenging situations. Pedagogical design for such a process has different foci in the four central phases: planning, project initiation, project execution, and presentation and evaluation. Planning and initiation are central to establishing relevance and project awareness for the collaboration of student teams with a customer. Guidance and expert modeling during project initiation and execution is needed to overcome feelings of uncertainty during a challenging and complex assignment. Mediation provided by collaboration tools facilitates reflection on collective practices, iterative development of knowledge objects, and documentation of the learning outcomes of customer projects.

  8. DESIGN OF 3D MODEL OF CUSTOMIZED ANATOMICALLY ADJUSTED IMPLANTS

    Directory of Open Access Journals (Sweden)

    Miodrag Manić

    2015-12-01

    Full Text Available Design and manufacturing of customized implants is a field that has been rapidly developing in recent years. This paper presents an originally developed method for designing a 3D model of customized anatomically adjusted implants. The method is based upon a CT scan of a bone fracture. A CT scan is used to generate a 3D bone model and a fracture model. Using these scans, an indicated location for placing the implant is recognized and the design of a 3D model of customized implants is made. With this method it is possible to design volumetric implants used for replacing a part of the bone or a plate type for fixation of a bone part. The sides of the implants, this one lying on the bone, are fully aligned with the anatomical shape of the bone surface which neighbors the fracture. The given model is designed for implants production utilizing any method, and it is ideal for 3D printing of implants.

  9. A comparative study of the efficacy of four different bristle designs of tooth brushes in plaque removal

    Directory of Open Access Journals (Sweden)

    Sripriya N

    2007-06-01

    Full Text Available Background : The aim of the study was to compare the efficacy of four most commonly used bristle designs of toothbrushes in plaque removal. Materials and Methods : The study was a randomized 4 cell, examiner blind cross-over design assessing the plaque removal efficacy of all four brushes on a single occasion. Sixteen subjects aged 14-15 years participated in the study. On day 1 of each test period, the subjects were rendered plaque free and were asked to suspend oral hygiene practices for 24 hours. On day 2, the subjects were scored for plaque prior to brushing using the Turesky-Gilmore modification of Quigley-Hein plaque index. The subjects then brushed with the allocated toothbrush for 2 minutes and the post-brushing plaque scores were assessed. A wash-out period of 4 days was allowed between the test periods. Results : All the brushes showed a significant reduction in the post-brushing plaque scores ( p < 0.001. The mean reduction in the plaque scores for all the brushes was around 53%. The percentage plaque reduction was greater in the anterior surface than the posterior surface (59.6 ± 7.45% vs. 49.83 ± 4.35%. The percentage plaque reductions in the upper, lower, buccal and lingual surfaces were similar. No significant difference in the reduction of plaque scores between the four brushes was seen. Conclusion : The data derived from the study supports the contention of many researchers that there is no single superior design of manual toothbrush. Though minor and some site differences in favor of the brushes were seen, they were not statistically significant.

  10. Customization Product Design Based on User's Emotion and Needs

    Institute of Scientific and Technical Information of China (English)

    JIN Chun; ZHANG Chun-lin; LIU Wen-zhi

    2005-01-01

    The paper presents a design method that ensures the ingenuity of the product form as well as the whole and exact expression of user's needs. The key idea is to establish an automatic design system which can transform the users language needs into the product features in real-time. A rifle was taken as a research instance and soldiers were chosen as evaluation customers. The theory of fuzzy set and semantic difference are adopted to evaluate the relationship between user's needs and product features as well as their alternatives. FAHP (fuzzy analytic hierarchy process) is utilized to judge the users satisfactory forms. This method can also be applied to other product form designs.

  11. The interplay between customer participation and difficulty of design examples in the online designing process and its effect on customer satisfaction: mediational analyses.

    Science.gov (United States)

    Chang, Chia-Chi; Chen, Hui-Yun; Huang, I-Chiang

    2009-04-01

    In the current consumer-centric economy, consumers increasingly desire the opportunity to design their own products in order to express more effectively their self-image. Mass customization, based on efficient and flexible modulization designs, has provided individualized products to satisfy this desire. This work presents an experiment employed to demonstrate that customer participation leads to higher satisfaction. Specifically, the increment in customer satisfaction due to participation is greater when an easy example is provided than when either no example or a difficult one is provided. Additionally, self-congruity plays a mediating role on the customer participation-satisfaction relationship, and this mediating effect varies across different levels of the design example provided in the design process. When an easy design example is present, customer participation has a direct effect on satisfaction, in addition to the indirect effect of self-congruity. When a difficult example is provided, customer participation does not have incremental effects on either self-congruity or customer satisfaction. Finally, when no design example is shown to customers, contrary to our expectation, participation still enhances customer satisfaction due to an increased sense of self-congruity.

  12. QUALITY FUNCTION DEPLOYMENT FOR INCORPORATING THE NEED OF THE CUSTOMERS FOR PRODUCT DEVELOPMENT AND DESIGN

    Directory of Open Access Journals (Sweden)

    Mrs. Reena Pant

    2013-04-01

    Full Text Available There are wealth of studies which show the desirability of involving real customers in the design process so that the problems customers have with the product can be examined and eliminated before the actualproduction starts. The Total Quality Management (TQM provides tools for the benefits and involvement the customers. A product is also developed for the customer. Hence the objective of two fields are same – The customers. Hence when these two fields work together the product will definitely be the result of actual customer ideas, When the focus is on the customers then the significance of the ergonomics also cannot be omitted as it also works for the satisfaction of the customers. In this paper an attempt is made to develop a methodology to involve the customers in ergonomic product development and design. The TQM tool selected for the purpose is Quality Function Deployment (QFD. The product Air Conditioner is used for the application of QFD.

  13. Drivers of Customer Satisfaction for Software Products: Implications for Design and Service Support

    OpenAIRE

    Sunder Kekre; Mayuram S. Krishnan; Kannan Srinivasan

    1995-01-01

    We study the key determinants of customer satisfaction with software products. Our analysis, based upon a large sample of over 2,500 customer responses, suggests that capability and usability are the critical drivers of overall customer satisfaction. We also find that the importance of seven key satisfaction factors differs across customer and product segments. Our results have significant implications for Quality Function Deployment in making design and service support choices for software p...

  14. Are You Being Served? Designing the Customer Service Curriculum

    Science.gov (United States)

    Ippoliti, Cinthya

    2014-01-01

    Customer service is a core component of user experience and an important element in making patrons feel welcomed and valued within our libraries. At the University of Maryland Libraries, we took on the challenging task of creating a customer service training curriculum for all staff working at public service points and offering a digital badge for…

  15. Innovative Product Design Based on Comprehensive Customer Requirements of Different Cognitive Levels

    Directory of Open Access Journals (Sweden)

    Xiaolong Li

    2014-01-01

    Full Text Available To improve customer satisfaction in innovative product design, a topology structure of customer requirements is established and an innovative product approach is proposed. The topology structure provides designers with reasonable guidance to capture the customer requirements comprehensively. With the aid of analytic hierarchy process (AHP, the importance of the customer requirements is evaluated. Quality function deployment (QFD is used to translate customer requirements into product and process design demands and pick out the technical requirements which need urgent improvement. In this way, the product is developed in a more targeted way to satisfy the customers. the theory of innovative problems solving (TRIZ is used to help designers to produce innovative solutions. Finally, a case study of automobile steering system is used to illustrate the application of the proposed approach.

  16. Innovative product design based on comprehensive customer requirements of different cognitive levels.

    Science.gov (United States)

    Li, Xiaolong; Zhao, Wu; Zheng, Yake; Wang, Rui; Wang, Chen

    2014-01-01

    To improve customer satisfaction in innovative product design, a topology structure of customer requirements is established and an innovative product approach is proposed. The topology structure provides designers with reasonable guidance to capture the customer requirements comprehensively. With the aid of analytic hierarchy process (AHP), the importance of the customer requirements is evaluated. Quality function deployment (QFD) is used to translate customer requirements into product and process design demands and pick out the technical requirements which need urgent improvement. In this way, the product is developed in a more targeted way to satisfy the customers. the theory of innovative problems solving (TRIZ) is used to help designers to produce innovative solutions. Finally, a case study of automobile steering system is used to illustrate the application of the proposed approach.

  17. Built by Design: Developing a Customized Marketing Department.

    Science.gov (United States)

    Hoffman, Jeffrey

    2003-01-01

    Discusses steps for building a customized, adequately staffed union and student activities marketing department so that union marketing activities and expenses fit into a well-considered structure and can be evaluated for their contribution to meeting organizational goals. (EV)

  18. Improving Customer Home-like Feeling Through Service Design

    OpenAIRE

    Hoang, Thu

    2015-01-01

    This thesis project was commissioned by Original Sokos Hotel Albert to investigate the hotel’s needs and customer demands. The aim of the project is to understand the connection between customer expectations and business strategy to generate higher service value. Sokos Hotel Albert offers hotel and restaurant services and the purpose of the thesis project is to improve the hotel customers’ home-like feelings. The project focuses on increasing the variety of the hotel services and solving the ...

  19. A Prototype Design for Enhancing Customer Trust in Online Payments

    OpenAIRE

    Thair A. Dalain; Peter Summons

    2009-01-01

    Problem statement: The adoption of mobile device technology can contribute significantly to enhance customers trust in online payment systems. Approach: The perceptions and preferences of online shoppers are influenced by several key factors which serve to both enhance and compromise this trust and in turn affect a customer intentions and behavior in relation to use online payment systems. The first part of the research was a quantitative study to investigate these factors. In the second part...

  20. Custom Unit Pump Design and Testing for the EVA PLSS

    Science.gov (United States)

    Schuller, Michael; Kurwitz, Cable; Goldman, Jeff; Morris, Kim; Trevino, Luis

    2009-01-01

    This paper describes the effort by the Texas Engineering Experiment Station (TEES) and Honeywell for NASA to design and test a pre-flight prototype pump for use in the Extra-vehicular activity (EVA) portable life support subsystem (PLSS). Major design decisions were driven by the need to reduce the pump s mass, power, and volume compared to the existing PLSS pump. In addition, the pump must accommodate a much wider range of abnormal conditions than the existing pump, including vapor/gas bubbles and increased pressure drop when employed to cool two suits simultaneously. A positive displacement, external gear type pump was selected because it offers the most compact and highest efficiency solution over the required range of flow rates and pressure drops. An additional benefit of selecting a gear pump design is that it is self priming and capable of ingesting non-condensable gas without becoming air locked. The chosen pump design consists of a 28 V DC, brushless, sealless, permanent magnet motor driven, external gear pump that utilizes a Honeywell development that eliminates the need for magnetic coupling. Although the planned flight unit will use a sensorless motor with custom designed controller, the pre-flight prototype to be provided for this project incorporates Hall effect sensors, allowing an interface with a readily available commercial motor controller. This design approach reduced the cost of this project and gives NASA more flexibility in future PLSS laboratory testing. The pump design was based on existing Honeywell designs, but incorporated features specifically for the PLSS application, including all of the key features of the flight pump. Testing at TEES verified that the pump meets the design requirements for range of flow rates, pressure drop, power consumption, working fluid temperature, operating time, gas ingestion , and restart capability under both ambient and vacuum conditions. The pump operated between 40 and 240 lbm/hr flowrate, 35 to 100 F

  1. A Prototype Design for Enhancing Customer Trust in Online Payments

    Directory of Open Access Journals (Sweden)

    Thair A. Dala’in

    2009-01-01

    Full Text Available Problem statement: The adoption of mobile device technology can contribute significantly to enhance customers trust in online payment systems. Approach: The perceptions and preferences of online shoppers are influenced by several key factors which serve to both enhance and compromise this trust and in turn affect a customer intentions and behavior in relation to use online payment systems. The first part of the research was a quantitative study to investigate these factors. In the second part of this research, a mobile payment model for online payment systems was proposed. In this model, the customers do not need to trust merchants during the transaction because merchants will not act as an intermediary between customers and the acquirer. Customers can therefore send their financial details without concern of disclosure, or potential misuse by the merchant. Results: In this study, the key factors influencing to adopt mobile payment systems were identify. The proposed model was developed and an analysis of the model architecture against conventional online payment systems was discussed. Conclusion/Recommendations: The significance of this research comes from providing a practical mobile payment model as a possible step towards increasing customer acceptance of online shopping and increasing their trust in online payment systems. The new model focuses on enhancing the feeling of security of the use of an online payment system and satisfying the security requirements.

  2. Evaluation of two soft manual toothbrushes with different filament designs in relation to gingival abrasion and plaque removing efficacy

    NARCIS (Netherlands)

    Versteeg, P.A.; Rosema, N.A.M.; Timmerman, M.F.; van der Velden, U.; van der Weijden, G.A.

    2008-01-01

    Objectives: To evaluate the effect of two soft manual toothbrushes with different filament and brush head designs in relation to gingival abrasion and plaque removing efficacy to the in relation flat trimmed manual reference toothbrush of the American Dental Association (ADA). Methods: The study had

  3. The Joint Effect of Competition and Complexity on Customer Accounting System Design

    DEFF Research Database (Denmark)

    Holm, Morten; Ax, Christian

    The importance of measuring customer profitability has recently been reiterated by the management accounting community. However, the stream of research on the factors influencing customer accounting (CA) design choices is still scarce and inconclusive. This paper addresses how the level of comple...... in particular as well as the general research stream on environmental factors’ influence on the sophistication and use of management accounting systems across firms.......The importance of measuring customer profitability has recently been reiterated by the management accounting community. However, the stream of research on the factors influencing customer accounting (CA) design choices is still scarce and inconclusive. This paper addresses how the level...

  4. TECHNOLOGY AND APPLICATION OF PRODUCT EVOLUTIONARY DESIGN BASED ON CONFIGURATION IN MASS CUSTOMIZATION MODE

    Institute of Scientific and Technical Information of China (English)

    FENG Yixiong; CHENG Jin; TAN Jianrong; ZHENG Bing; WEI Zhe

    2007-01-01

    Product customization has been recognized as an effective means to implement mass customization (MC). A new theory and method for MC-oriented evolutionary design of configuration product is presented based on the study of developing law of evolutionary design in integrated environment, which focuses on the innovation and reuse properties of configuration product. The key technologies for general requirement modeling in quick response to customer requirement, multi-level stepwise configuration optimization driven by customer requirement and evolutionary deduction of product variable structure based on configuration association are thoroughly investigated. The successful application of the presented method in the development of real-life products demonstrates its utility, flexibility and robusticity.

  5. Management Education Benchmarking Designing Customized and Flexible MBA Programs

    Science.gov (United States)

    Hall, Owen P., Jr.; Young, Terry W.

    2007-01-01

    To meet the challenges of the 21st century B-schools are revising curriculum, delivery and outcome assessment modalities. Today, the proportion of electives and other specialty offerings in many MBA programs now constitutes more than 50% of the total curriculum. However, this focus on customization, integration and flexibility is not without its…

  6. An Electronic Service Quality Reference Model for Designing E-Commerce Websites Which Maximizes Customer Satisfaction

    Science.gov (United States)

    Shaheen, Amer N.

    2011-01-01

    This research investigated Electronic Service Quality (E-SQ) features that contribute to customer satisfaction in an online environment. The aim was to develop an approach which improves E-CRM processes and enhances online customer satisfaction. The research design adopted mixed methods involving qualitative and quantitative methods to…

  7. The Joint Effect of Competition and Complexity on Customer Accounting System Design

    DEFF Research Database (Denmark)

    Holm, Morten; Ax, Christian

    The importance of measuring customer profitability has recently been reiterated by the management accounting community. However, the stream of research on the factors influencing customer accounting (CA) design choices is still scarce and inconclusive. This paper addresses how the level...... in particular as well as the general research stream on environmental factors’ influence on the sophistication and use of management accounting systems across firms....

  8. An Electronic Service Quality Reference Model for Designing E-Commerce Websites Which Maximizes Customer Satisfaction

    Science.gov (United States)

    Shaheen, Amer N.

    2011-01-01

    This research investigated Electronic Service Quality (E-SQ) features that contribute to customer satisfaction in an online environment. The aim was to develop an approach which improves E-CRM processes and enhances online customer satisfaction. The research design adopted mixed methods involving qualitative and quantitative methods to…

  9. DESIGNING A MODEL OF CUSTOMER RELATIONSHIP MANAGEMENT FOR A MOBILE PHONE COMPANY

    Directory of Open Access Journals (Sweden)

    BRUTU MĂDĂLINA

    2015-07-01

    Full Text Available Customer relationship management refers to establishing, maintaining, developing and optimizing the relations between an organization and its customers and focuses on understanding and meeting its customers’ wishes and demands, the core items of the business strategy of any performant company. This paper aims at designing and testing a model of customer relationship management applicable within a mobile phone company. Starting from this purpose, the main objectives of the research were: presenting the concept of customer relationship management; the importance of companies’ orientation to the market; identifying a model of customer relationship management and, not least, analyzing the efficiency of this model. The results lead to the conclusion that the model of customer relationship management is extremely effective in the mobile phone industry, bringing significant profits.

  10. A Novel Software Tool to Generate Customer Needs for Effective Design of Online Shopping Websites

    OpenAIRE

    Sharma, Ashish K; Sunanda Khandait

    2016-01-01

    —Effective design of online shopping websites is the need of the hour as design plays a crucial role in the success of online shopping businesses. Recently, the use of Quality Function Deployment (QFD) has been reported for the design of online shopping websites. QFD is a customer driven process that encompasses voluminous data gathered from customers through several techniques like personal interview, focus groups, surveys etc. This massive, unsorted and unstructured ...

  11. The Joint Effect of Competition and Complexity on Customer Accounting System Design

    DEFF Research Database (Denmark)

    Holm, Morten; Ax, Christian

    The importance of measuring customer profitability has recently been reiterated by the management accounting community. However, the stream of research on the factors influencing customer accounting (CA) design choices is still scarce and inconclusive. This paper addresses how the level...... service complexity; (ii) There is a direct positive relationship between customer service complexity and CPA model sophistication; (iii) This positive association is stronger when competition is non-price based than when competition is price based. The study hereby contributes to research on CA design...... in particular as well as the general research stream on environmental factors’ influence on the sophistication and use of management accounting systems across firms....

  12. Multidisciplinary design optimization to identify additive manufacturing resources in customized product development

    Directory of Open Access Journals (Sweden)

    Xiling Yao

    2017-04-01

    Full Text Available Additive manufacturing (AM techniques are ideal for producing customized products due to their high design flexibility. Despite the previous studies on specific additive manufactured customized products such as biomedical implants and prostheses, the simultaneous optimization of components, materials, AM processes, and dimensions remains a challenge. Multidisciplinary design optimization (MDO is a research area of solving complex design problems involving multiple disciplines which usually interact with each other. The objective of this research is to formulate and solve an MDO problem in the development of additive manufactured products customized for various customers in different market segments. Three disciplines, i.e. the customer preference modeling, AM production costing, and structural mechanics are incorporated in the MDO problem. The optimal selections of components, materials, AM processes, and dimensional parameters are searched with the objectives to maximize the functionality utility, match individual customers’ personal performance requirements, and minimize the total cost. A multi-objective genetic algorithm with the proposed chromosome encoding pattern is applied to solve the MDO problem. A case study of designing customized trans-tibial prostheses with additive manufactured components is presented to illustrate the proposed MDO method. Clusters of multi-dimensional Pareto-optimal design solutions are obtained from the MDO, showing trade-offs among the objectives. Appropriate design decision can be chosen from the clusters based on the manufacturer׳s market strategy.

  13. Applying CBR to machine tool product configuration design oriented to customer requirements

    Science.gov (United States)

    Wang, Pengjia; Gong, Yadong; Xie, Hualong; Liu, Yongxian; Nee, Andrew Yehching

    2017-01-01

    Product customization is a trend in the current market-oriented manufacturing environment. However, deduction from customer requirements to design results and evaluation of design alternatives are still heavily reliant on the designer's experience and knowledge. To solve the problem of fuzziness and uncertainty of customer requirements in product configuration, an analysis method based on the grey rough model is presented. The customer requirements can be converted into technical characteristics effectively. In addition, an optimization decision model for product planning is established to help the enterprises select the key technical characteristics under the constraints of cost and time to serve the customer to maximal satisfaction. A new case retrieval approach that combines the self-organizing map and fuzzy similarity priority ratio method is proposed in case-based design. The self-organizing map can reduce the retrieval range and increase the retrieval efficiency, and the fuzzy similarity priority ratio method can evaluate the similarity of cases comprehensively. To ensure that the final case has the best overall performance, an evaluation method of similar cases based on grey correlation analysis is proposed to evaluate similar cases to select the most suitable case. Furthermore, a computer-aided system is developed using MATLAB GUI to assist the product configuration design. The actual example and result on an ETC series machine tool product show that the proposed method is effective, rapid and accurate in the process of product configuration. The proposed methodology provides a detailed instruction for the product configuration design oriented to customer requirements.

  14. Applying CBR to machine tool product configuration design oriented to customer requirements

    Science.gov (United States)

    Wang, Pengjia; Gong, Yadong; Xie, Hualong; Liu, Yongxian; Nee, Andrew Yehching

    2016-03-01

    Product customization is a trend in the current market-oriented manufacturing environment. However, deduction from customer requirements to design results and evaluation of design alternatives are still heavily reliant on the designer's experience and knowledge. To solve the problem of fuzziness and uncertainty of customer requirements in product configuration, an analysis method based on the grey rough model is presented. The customer requirements can be converted into technical characteristics effectively. In addition, an optimization decision model for product planning is established to help the enterprises select the key technical characteristics under the constraints of cost and time to serve the customer to maximal satisfaction. A new case retrieval approach that combines the self-organizing map and fuzzy similarity priority ratio method is proposed in case-based design. The self-organizing map can reduce the retrieval range and increase the retrieval efficiency, and the fuzzy similarity priority ratio method can evaluate the similarity of cases comprehensively. To ensure that the final case has the best overall performance, an evaluation method of similar cases based on grey correlation analysis is proposed to evaluate similar cases to select the most suitable case. Furthermore, a computer-aided system is developed using MATLAB GUI to assist the product configuration design. The actual example and result on an ETC series machine tool product show that the proposed method is effective, rapid and accurate in the process of product configuration. The proposed methodology provides a detailed instruction for the product configuration design oriented to customer requirements.

  15. Building Store Satisfaction Centred on Customer Retention in Clothing Retailing: Store Design and Ease of Shopping

    Directory of Open Access Journals (Sweden)

    Gulden Turhan

    2016-01-01

    Full Text Available The study’s research model suggests that store design and ease of shopping are associated with customer retention through a mediated pathway in which store design and ease of shopping influence perceived store satisfaction, which in turn, influences customer retention. This survey was administered to two separate clothing stores offered to either females or males (in total, 533 participants. Using structural equation modelling methodology, data was analysed to explain the interrelations among the variables in the model. The results of an empirical study of a sample of store shoppers revealed that store design and ease of shopping influence customer retention in an indirect way through customer perception of satisfaction with the store. In building store satisfaction that is centred on customer retention, store design and shopping ease differ in their relative influences. This difference is high for females, but for men as low as to be considered negligible in males. As a result, improving customers’ perceptions of store design and ease of shopping is a way to ensure store satisfaction support customer retention. The results of the study provide a new insight into the relationships by suggesting indirect effects of shopping ease and store design on consumer retention by their impacts on store satisfaction, rather than direct effects.

  16. USER REQUIREMENTS CUSTOMIZATION AND ATTRACTIVE QUALITY CREATION FOR DESIGN IMPROVEMENT ATTRIBUTES

    Directory of Open Access Journals (Sweden)

    Ismail Wilson Taifa

    2017-03-01

    Full Text Available The aim of this paper was to customize user requirements and quality creation for design improvement of furniture. The major purpose has been achieved with the use of Quality Function Deployment technique and Kano Model. The study involved 564 students from 3 engineering colleges. Extensive user requirements were identified with the help of Questionnaires. The use of House of Quality, Kano Model and Pareto Diagram helped in prioritizing all important features which are needed in customizing user requirements. The prioritized requirements include ergonomic design, desk adjustability, comfortability, product corners (sharp corners and latest material. All these factors both got high relative and absolute weight. Therefore, more engineering efforts need to be directed towards these requirements for achieving user customization for design improvement. The developed House of Quality with the help of Kano Model results has proved to be a good tool in customizing user requirements.

  17. Custom design in lower limb prosthetics for athletic activity.

    Science.gov (United States)

    Fergason, J R; Boone, D A

    2000-08-01

    In summary, the prosthetist is the best source of information with regard to the fast-changing lower extremity prosthetics technology for sports. The needs and desires of the amputee should be outlined and balanced with the cost of the desired components and design. In many cases, one carefully designed prosthesis can serve in dual roles for everyday ambulation and certain athletic activities. In other cases, the amputee is limited severely by a prosthesis that is not designed for a specific activity. Using a prosthesis for activities that it was not designed to accommodate can cause physical injury to the amputee as well as structural failure of the device. A properly designed and fitted prosthesis can open a whole new world of activity to the amputee and helps him or her to reach the desired a vocational goals.

  18. Computational Tools and Algorithms for Designing Customized Synthetic Genes

    Directory of Open Access Journals (Sweden)

    Nathan eGould

    2014-10-01

    Full Text Available Advances in DNA synthesis have enabled the construction of artificial genes, gene circuits, and genomes of bacterial scale. Freedom in de-novo design of synthetic constructs provides significant power in studying the impact of mutations in sequence features, and verifying hypotheses on the functional information that is encoded in nucleic and amino acids. To aid this goal, a large number of software tools of variable sophistication have been implemented, enabling the design of synthetic genes for sequence optimization based on rationally defined properties. The first generation of tools dealt predominantly with singular objectives such as codon usage optimization and unique restriction site incorporation. Recent years have seen the emergence of sequence design tools that aim to evolve sequences toward combinations of objectives. The design of optimal protein coding sequences adhering to multiple objectives is computationally hard, and most tools rely on heuristics to sample the vast sequence design space. In this review we study some of the algorithmic issues behind gene optimization and the approaches that different tools have adopted to redesign genes and optimize desired coding features. We utilize test cases to demonstrate the efficiency of each approach, as well as identify their strengths and limitations.

  19. Customer Relationship Management System in Occupational Safety & Health Companies: Research on Practice and Preliminary Design Solution

    Directory of Open Access Journals (Sweden)

    Robert Fabac

    2011-10-01

    Full Text Available One of the most prominent contemporary trends in formation of companies is the approach to development of a customer-oriented company. In this matter, various versions related to the intensity of this orientation are differentiated. Customer relationship management (CRM system is a well-known concept, and its practice is being studied and improved in connection to various sectors. Companies providing services of occupational safety and health (OHS mainly cooperate with a large number of customers and the quality of this cooperation largely affects the occupational safety and health of employees. Therefore, it is of both scientific and wider social interest to study and improve the relationship of these companies with their customers. This paper investigates the practice of applying CRM in Croatian OHS companies. It identifies the existing conditions and suggests possible improvements in the practice of CRM, based on experts’ assessments using analytic hierarchy process evaluation. Universal preliminary design was created as a framework concept for the formation of a typical customer-oriented OHS services company. Preliminary design includes a structural view, which provides more details through system diagrams, and an illustration of main cooperation processes of a company with its customer.

  20. An Empirical Analysis to Design Enhanced Customer Lifetime Value Based on Customer Loyalty: Evidences from Iranian Banking Sector

    Directory of Open Access Journals (Sweden)

    Mohammad Safari Kahreh

    2012-07-01

    Full Text Available The more a marketing paradigm evolves, the more long-term relationship with customers gains its importance. Also, the move towards a customer-centred approach to marketing, coupled with the increasing availability of customer transaction data, has led to an interest in understanding and estimating customer lifetime value (CLV. There are several researches about the CLV formulas and calculating relations. But the effect of the CLV on the other departments of the organization and especially the effect of the CLV on the key parameters for organization’s profitability such as customer loyalty and satisfaction had little attention. This research is about these shortcomings and covers another essential element for organizational sustainable profitability, customer loyalty. The main purpose of this research is to demonstrate the effect of customer loyalty on the customer lifetime value. For this purpose one of the biggest parts of service sector in Iran is selected and the data from this sector are gathered and analyzed. Banking sector is the biggest body of Iranian service sector of economy. By means of a valid questionnaire, data were gathered from banking sector and after analyzing the hypotheses, results show that the high customer loyalty strongly affects on the enhanced customer lifetime value. In the final section of this paper, both applied and theoretical recommendations will be provided.

  1. Custom Formula-Based Visualizations for Savvy Designers"

    DEFF Research Database (Denmark)

    Kuhail, Mohammad Amin

    . For instance, it would save time and money if a clinician familiar with spreadsheet formulas could refine a visualization (e.g. the lifelines) rather than hiring a programmer. Existing approaches to visualization are one of the two: accessible to savvy designers but limited in customizability, or inaccessible...

  2. Custom designed type family for corporat visual identity

    OpenAIRE

    Veršnik, Anže

    2012-01-01

    Recognition in a wide public area can invoke a lot of factors. Visual identity of every formal and informal organization is only one of those. In order to successfully communicate trough visual messages, they have to be designed systematically and thoughtfully, as only this way all aspects of a visual message will be achieved. The overview of the history of visual messages, with emphasis on the development of the written word is highlighted. This includes everything between the first pict...

  3. The Analysis And Design Of Customer Relationship Management Model At STMIK STIKOM BALI

    Directory of Open Access Journals (Sweden)

    Ni Wayan Deriani

    2016-06-01

    Full Text Available The advantages of an organization can be seen from the organization's ability to compete in the business world today is increasingly more competition. The competition should be used as well as possible in order to retain customers by providing the best service. one way to provide the best service is the provision of means in the form of comprehensive information systems and integrated. CRM is an integrated system that is useful for both of the organization and of course for the customer. In this research, design analysis model of CRM approach from the perspective Planner and owner of Zachman framework. Design analysis using DFD, ERD and conceptual database. The expected outcome of this research is a form of planning the Customer Relationship Management system model as a reference for the managers in the development of an integrated system in the future.

  4. Custom-designed nanomaterial libraries for testing metal oxide toxicity.

    Science.gov (United States)

    Pokhrel, Suman; Nel, André E; Mädler, Lutz

    2013-03-19

    Advances in aerosol technology over the past 10 years have enabled the generation and design of ultrafine nanoscale materials for many applications. A key new method is flame spray pyrolysis (FSP), which produces particles by pyrolyzing a precursor solution in the gas phase. FSP is a highly versatile technique for fast, single-step, scalable synthesis of nanoscale materials. New innovations in particle synthesis using FSP technology, including variations in precursor chemistry, have enabled flexible, dry synthesis of loosely agglomerated, highly crystalline ultrafine powders (porosity ≥ 90%) of binary, ternary, and mixed-binary-and-ternary oxides. FSP can fulfill much of the increasing demand, especially in biological applications, for particles with specific material composition, high purity, and high crystallinity. In this Account, we describe a strategy for creating nanoparticle libraries (pure or Fedoped ZnO or TiO₂) utilizing FSP and using these libraries to test hypotheses related to the particles' toxicity. Our innovation lies in the overall integration of the knowledge we have developed in the last 5 years in (1) synthesizing nanomaterials to address specific hypotheses, (2) demonstrating the electronic properties that cause the material toxicity, (3) understanding the reaction mechanisms causing the toxicity, and (4) extracting from in vitro testing and in vivo testing in terrestrial and marine organisms the essential properties of safe nanomaterials. On the basis of this acquired knowledge, we further describe how the dissolved metal ion from these materials (Zn²⁺ in this Account) can effectively bind with different cell constituents, causing toxicity. We use Fe-S protein clusters as an example of the complex chemical reactions taking place after free metal ions migrate into the cells. As a second example, TiO₂ is an active material in the UV range that exhibits photocatalytic behavior. The induction of electron-hole (e⁻/h⁺) pairs followed by

  5. A Customer-driven Model of Job Design: Towards a General Theory.

    Science.gov (United States)

    Conti, Robert F.; Warner, Malcolm

    2002-01-01

    Ten production sites in the United Kingdom, North America, Japan, and Malta tested a model of worker discretion in job tasks, based on customer preferences. Results suggest that production jobs should be designed to maximize worker judgment, knowledge, and initiative, allowing broad discretion in all tasks except those that can have a negative…

  6. Engineering specification and system design for CAD/CAM of custom shoes: UMC project effort

    Science.gov (United States)

    Bao, Han P.

    1991-01-01

    The goal of this project is to supplement the footwear design system of North Carolina State University (NCSU) with a software module to design and manufacture a combination sole. The four areas of concentration were: customization of NASCAD (NASA Computer Aided Design) to the footwear project; use of CENCIT data; computer aided manufacturing activities; and beginning work for the bottom elements of shoes. The task of generating a software module for producing a sole was completed with a demonstrated product realization. The software written in C was delivered to NCSU for inclusion in their design system for custom footwear known as LASTMOD. The machining process of the shoe last was improved using a spiral tool path approach.

  7. Design, Customization and Implementation of Energy Simulation with 5E Model in Elementary Classroom

    CERN Document Server

    Lye, Sze Yee; Kwek, Yao Chie; Abas, Suriati; Tay, Lee Yong

    2014-01-01

    Science simulations are popular among educators as such simulations afford for multiple visual representation and interactivity. Despite the popularity and abundance on the internet, our literature review suggested little research has been conducted on the use of simulation in elementary school. Thus, an exploratory pilot case study was conducted to address this research gap. In this study, an open source energy simulation was remixed for use in elementary school targeted at the Grade 4 & 5 students as an after-school enrichment program. We proposed 3 stages: design, customization and implementation, to provide useful insights with the aim to allow other educators to conduct their own remixed simulation lessons. The simulation design principles (e.g., learning outcomes and colour coding) with the corresponding TPACK construct that emerged from the design and customization stages were reported. Such simulation design principles would be useful to interested educators and researchers who wish to adapt and u...

  8. Optimized Design of 2D Mesh NOC Router using Custom SRAM & Common Buffer Utilization

    Directory of Open Access Journals (Sweden)

    Bhavana Pote

    2011-12-01

    Full Text Available With the shrinking technology, reduced scale and power-hungry chip IO leads to System on Chip. The design of SOC using traditional standard bus scheme encounters with issues like non-uniform delay and routing problems. Crossbars could scale better when compared to buses but tend to become huge with increasing number of nodes. NOC has become the design paradigm for SOC design for its highly regularized interconnect structure, good scalability and linear design effort. The main components of an NoC topology are the network adapters, routing nodes, and network interconnect links. This paper mainly deals with the implementation of full custom SRAM based arrays over D FF based register arrays in the design of input module of routing node in 2D mesh NOC topology. The custom SRAM blocks replace D FF(D flip flop memory implementations to optimize area and power of the input block. Full custom design of SRAMs has been carried out by MILKYWAY, while physical implementation of the input module with SRAMs has been carried out by IC Compiler of SYNOPSYS.The improved design occupies approximately 30% of the area of the original design. This is in conformity to the ratio of the area of an SRAM cell to the area of a D flip flop, which is approximately 6:28.The power consumption is almost halved to 1.5 mW. Maximum operating frequency is improved from 50 MHz to 200 MHz. It is intended to study and quantify the behavior of the single packet array design in relation to the multiple packet array design. Intuitively, a common packet buffer would result in better utilization of available buffer space. This in turn would translate into lower delays in transmission. A MATLAB model is used to show quantitatively how performance is improved in a common packet array design.

  9. Customization Issues

    DEFF Research Database (Denmark)

    Jørgensen, Kaj Asbjørn; Brunø, Thomas Ditlev; Taps, Stig B.

    2014-01-01

    Implementation of mass customization and product configuration in companies requires fundamental considerations about how products can fulfil the demand from customers. In order to support such decision-making, a multi-level model for customization is developed. This model identifies four different...... levels of customization, ranging from the structure level at the bottom, through the performance level and the experience level, to the learning level at the top. The model also has a dual view with customers/demand at one side and product/supplier at the other side. It is a rather general model, which...... can be applied to many types of products, and typically, product designers must decide how far up in levels the customization should aim. In this paper, the four-level customization model is applied to wheel chairs....

  10. A Novel Software Tool to Generate Customer Needs for Effective Design of Online Shopping Websites

    Directory of Open Access Journals (Sweden)

    Ashish K. Sharma

    2016-03-01

    Full Text Available —Effective design of online shopping websites is the need of the hour as design plays a crucial role in the success of online shopping businesses. Recently, the use of Quality Function Deployment (QFD has been reported for the design of online shopping websites. QFD is a customer driven process that encompasses voluminous data gathered from customers through several techniques like personal interview, focus groups, surveys etc. This massive, unsorted and unstructured data is required to be transformed into a limited number of structured information to represent the actual Customer Needs (CNs which are then utilized in subsequent stages of QFD process. This can be achieved through brainstorming using techniques like Affinity Process. However, integrating the Affinity Process within QFD is tedious and time consuming and cannot be dealt with manually. This generates a pressing need for a software tool to serve the purpose. Moreover, the researches carried out so far have focused on QFD application, post the generation of CNs. Also, the available QFD softwares lack the option to generate CNs from collected data. Thus, the paper aims to develop a novel software tool that integrates Affinity Process with QFD to generate customers‘ needs for effective design of online shopping websites. The software system is developed using Visual Basic Dot Net (VB.Net that integrates a MS-Access database.

  11. A comparative study on the customized design of mandibular reconstruction plates using finite element method

    Directory of Open Access Journals (Sweden)

    Abdulrahman Al-Ahmari

    2015-07-01

    Full Text Available Mandible defects and its deformities are serious complications and its precise reconstruction is one of the most challenging tasks in oral maxillofacial surgery. The commercially available standard mandible implants are manually bended before surgery to custom fit the patient’s jaw. A slight mismatch in the plate and bone alignment may result in the implant failure. However, with the integration of computer-aided design, rapid prototyping, and advanced imaging systems (computed tomography or magnetic resonance imaging, it is possible to produce a customized mandible implant that can precisely fit the patient’s jaw. The aim of this article is to compare a new design of customized mandible implant (sinewave plate and compare it with the commonly used straight implant design. The finite element–simulated results reveal that the commonly used straight reconstruction plates are more prone to loosening of the screws due to its higher strain concentration on the screw hole when compared to newly designed sinewave reconstruction plate. Moreover, the straight plate is more sensitive to the chewing load variations and develops almost 20% increase in the stresses when compared to sinewave plate. The study reveals that the sinewave reconstruction plate can significantly enhance the stability and safety of the mandible implant.

  12. Sensory evaluation based fuzzy AHP approach for material selection in customized garment design and development process

    Science.gov (United States)

    Hong, Y.; Curteza, A.; Zeng, X.; Bruniaux, P.; Chen, Y.

    2016-06-01

    Material selection is the most difficult section in the customized garment product design and development process. This study aims to create a hierarchical framework for material selection. The analytic hierarchy process and fuzzy sets theories have been applied to mindshare the diverse requirements from the customer and inherent interaction/interdependencies among these requirements. Sensory evaluation ensures a quick and effective selection without complex laboratory test such as KES and FAST, using the professional knowledge of the designers. A real empirical application for the physically disabled people is carried out to demonstrate the proposed method. Both the theoretical and practical background of this paper have indicated the fuzzy analytical network process can capture expert's knowledge existing in the form of incomplete, ambiguous and vague information for the mutual influence on attribute and criteria of the material selection.

  13. Custom-Shaped Organic Photovoltaic Modules—Freedom of Design by Printing

    Science.gov (United States)

    Välimäki, M.; Jansson, E.; Korhonen, P.; Peltoniemi, A.; Rousu, S.

    2017-02-01

    Freedom of design that was introduced as organic photovoltaic (OPV) modules were fabricated by printing. As proof-of-concept, we show OPV leaf fabrication in A5 size using gravure and rotary screen printing processes for the main active layers of the OPV structure. These printing methods allow direct printing of any kind of arbitrary, two-dimensional shapes including patterning of the electric contacts thus post-patterning stages are not needed. Fabrication of custom-shaped OPV modules requires detailed information about the technical boundaries set by the manufacturing process and materials which in turn influence the layout design and R2R upscaling. In this paper, we show custom-shaped OPV modules, patterned directly in a shape of a tree leaf with an overall size of 110 cm2 and an active area of 50 cm2 providing a power conversion efficiency of 2.0% and maximum power of 98 mW.

  14. Custom Chipset and Compact Module Design for a 75-110 GHz Laboratory Signal Source

    CERN Document Server

    Morgan, Matthew A; Castro, Jason J

    2016-01-01

    We report on the development and characterization of a compact, full-waveguide bandwidth (WR-10) signal source for general-purpose testing of mm-wave components. The MMIC-based multichip module is designed for compactness and ease-of-use, especially in size-constrained test sets such as a wafer probe station. It takes as input a cm-wave CW reference and provides a factor of three frequency multiplication as well as amplification, output power adjustment, and in-situ output power monitoring. It utilizes a number of custom MMIC chips such as a Schottky-diode limiter and a broadband mm-wave detector, both designed explicitly for this module, as well as custom millimeter-wave multipliers and amplifiers reported in previous papers.

  15. Designing Customer Education Activities to Change People’s Perception of Catfish

    Directory of Open Access Journals (Sweden)

    Stevanus Pratama Suwito

    2017-06-01

    Full Text Available Most people see catfish as an unhygienic fish, so less people want to consume it. In fact, catfish has better nutrition compared to Gourami. Therefore, catfish producers need to educate people. The purpose of this research is to design customer education activities to change people’s perception towards catfish using marketing communication mix. This research is a qualitative research and it uses in-depth interview method in gathering the required data. Based on the preliminary survey conducted to 50 people in Surabaya, it is known that Surabaya people are considered novice customers. As such, catfish producers can conduct customer education activities until people want to taste the catfish. The company can add picture, video, and oral information about the benefits in consuming catfish or the nutrition and the certificate of hygienic cultivation system. The producers can provide tester for the catfish and show the customers the comparison between good and bad quality catfish. The producers can also add two more marketing communication activities i.e. events and experiences as well as public relations and publicity. The producers need to use reliable sources in informing the catfish’s nutrition facts such as the certificate of catfish breeder, and certification from BPOM.

  16. ASPECTS ON 3D DESIGN OF ASSEMBLIES AND PART LISTS CUSTOMIZING WITH INVENTOR 2016

    Directory of Open Access Journals (Sweden)

    GOANTA Adrian Mihai

    2017-05-01

    Full Text Available The paper aims to present some aspects of the 3D design of assemblies obtained with Inventor 2016 referring to the constrains to pieces placed in the overall file, achievement of new items directly in the assembly concerned, inserting standardized elements in "Content Center" like standardized wedges, safety washers, bearings, etc. The second part of the paper describes how to customize the parts list/table in the drawing.

  17. A modified dynamic evolving neural-fuzzy approach to modeling customer satisfaction for affective design.

    Science.gov (United States)

    Kwong, C K; Fung, K Y; Jiang, Huimin; Chan, K Y; Siu, Kin Wai Michael

    2013-01-01

    Affective design is an important aspect of product development to achieve a competitive edge in the marketplace. A neural-fuzzy network approach has been attempted recently to model customer satisfaction for affective design and it has been proved to be an effective one to deal with the fuzziness and non-linearity of the modeling as well as generate explicit customer satisfaction models. However, such an approach to modeling customer satisfaction has two limitations. First, it is not suitable for the modeling problems which involve a large number of inputs. Second, it cannot adapt to new data sets, given that its structure is fixed once it has been developed. In this paper, a modified dynamic evolving neural-fuzzy approach is proposed to address the above mentioned limitations. A case study on the affective design of mobile phones was conducted to illustrate the effectiveness of the proposed methodology. Validation tests were conducted and the test results indicated that: (1) the conventional Adaptive Neuro-Fuzzy Inference System (ANFIS) failed to run due to a large number of inputs; (2) the proposed dynamic neural-fuzzy model outperforms the subtractive clustering-based ANFIS model and fuzzy c-means clustering-based ANFIS model in terms of their modeling accuracy and computational effort.

  18. The Dilemma of Customized Design%定制设计的困境

    Institute of Scientific and Technical Information of China (English)

    胡越

    2012-01-01

    建筑设计与艺术创作有很大的区别,而评论一个建筑的好坏,取决于建筑在城市中所扮演的角色.通过将现代建筑设计方法与服装中的成衣和高级定制设计进行类比,进而指出采用定制设计策略的现代建筑方法存在的问题,并对现代建筑设计未来的方向提出看法.%There is great difference between architectural design and the making of artwork, and [he quality of architecture is judged by its role in the urban context. This article makes comparison between modern architectural design methods and the customized design of ready-made clothes. From this, it clarifies some problems of modern architectural design methods with a customized design strategy, and puts forward some opinions about the future development of modern architectural design.

  19. Product Customization

    DEFF Research Database (Denmark)

    Hvam, Lars; Mortensen, Niels Henrik; Riis, Jesper

    For the majority of industrial companies, customizing products and services is among the most critical means to deliver true customer value and achieve superior competitive advantage. The challenge is not to customize products and services in itself – but to do it in a profitable way....... The implementation of a product configuration system is among the most powerful ways of achieving this in practice, offering a reduction of the lead time for products and quotations, faster and more qualified responses to customer inquiries, fewer transfers of responsibility and fewer specification mistakes......, a reduction of the resources spent for the specification of customized products, and the possibility of optimizing the products according to customer demands. This book presents an operational procedure for the design of product configuration systems in industrial companies, based on the experience gained...

  20. Thermal Performance of a Customized Multilayer Insulation (MLI). Design and Fabrication of Test Facility Hardware

    Science.gov (United States)

    Leonhard, K. E.

    1975-01-01

    The design, fabrication, and assembly of hardware for testing the performance of a customized multilayer insulation are discussed. System components described include the thermal payload simulator, the modified cryoshroud, and a tank back pressure control device designed to maintain a constant liquid boiling point during the thermal evaluation of the multilayer insulation. The thermal payload simulator will provide a constant temperature surface in the range of 20.5 to 417K (37 to 750R) for the insulated tank to view. The cryoshroud was modified to establish a low temperature black body cavity while limiting liquid hydrogen usage to a minimum feasible rate.

  1. Control of autonomous mobile robots using custom-designed qualitative reasoning VLSI chips and boards

    Energy Technology Data Exchange (ETDEWEB)

    Pin, F.G.; Pattay, R.S.

    1991-01-01

    Two types of computer boards including custom-designed VLSI chips have been developed to provide a qualitative reasoning capability for the real-time control of autonomous mobile robots. The design and operation of these boards are described and an example of application of qualitative reasoning for the autonomous navigation of a mobile robot in a-priori unknown environments is presented. Results concerning consistency and modularity in the development of qualitative reasoning schemes as well as the general applicability of these techniques to robotic control domains are also discussed. 17 refs., 4 figs.

  2. Impact of Rate Design Alternatives on Residential Solar Customer Bills. Increased Fixed Charges, Minimum Bills and Demand-based Rates

    Energy Technology Data Exchange (ETDEWEB)

    Bird, Lori [National Renewable Energy Lab. (NREL), Golden, CO (United States); Davidson, Carolyn [National Renewable Energy Lab. (NREL), Golden, CO (United States); McLaren, Joyce [National Renewable Energy Lab. (NREL), Golden, CO (United States); Miller, John [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-09-01

    With rapid growth in energy efficiency and distributed generation, electric utilities are anticipating stagnant or decreasing electricity sales, particularly in the residential sector. Utilities are increasingly considering alternative rates structures that are designed to recover fixed costs from residential solar photovoltaic (PV) customers with low net electricity consumption. Proposed structures have included fixed charge increases, minimum bills, and increasingly, demand rates - for net metered customers and all customers. This study examines the electricity bill implications of various residential rate alternatives for multiple locations within the United States. For the locations analyzed, the results suggest that residential PV customers offset, on average, between 60% and 99% of their annual load. However, roughly 65% of a typical customer's electricity demand is non-coincidental with PV generation, so the typical PV customer is generally highly reliant on the grid for pooling services.

  3. ROBUST DESIGN MODELS FOR CUSTOMER-SPECIFIED BOUNDS ON PROCESS PARAMETERS

    Institute of Scientific and Technical Information of China (English)

    Sangmun SHIN; Byung Rae CHO

    2006-01-01

    Robust design (RD) has received much attention from researchers and practitioners for years, and a number of methodologies have been studied in the research community. The majority of existing RD models focus on the minimum variability with a zero bias. However, it is often the case that the customer may specify upper bounds on one of the two process parameters (i.e., the process mean and variance). In this situation, the existing RD models may not work efficiently in incorporating the customer's needs. To this end, we propose two simple RD models using the ε-constraint feasible region method - one with an upper bound of process bias specified and the other with an upper bound on process variability specified. We then conduct a case study to analyze the effects of upper bounds on each of the process parameters in terms of optimal operating conditions and mean squarederror.

  4. Using virtual human for an interactive customer-oriented constrained environment design

    CERN Document Server

    Ma, Liang; Chablat, Damien; Bennis, Fouad

    2010-01-01

    For industrial product design, it is very important to take into account assembly/disassembly and maintenance operations during the conceptual and prototype design stage. For these operations or other similar operations in a constrained environment, trajectory planning is always a critical and difficult issue for evaluating the design or for the users' convenience. In this paper, a customer-oriented approach is proposed to partially solve ergonomic issues encountered during the design stage of a constrained environment. A single objective optimization based method is taken from the literature to generate the trajectory in a constrained environment automatically. A motion capture based method assists to guide the trajectory planning interactively if a local minimum is encountered within the single objective optimization. At last, a multi-objective evaluation method is proposed to evaluate the operations generated by the algorithm

  5. Design and milling manufacture of polyurethane custom contoured cushions for wheelchair users

    Directory of Open Access Journals (Sweden)

    Wilson Kindlein Junior

    2011-09-01

    Full Text Available BackgroundThe design of custom contoured cushions manufactured inflexible polyurethane foams is an option to improvepositioning and comfort for people with disabilities thatspend most of the day seated in the same position. Thesesurfaces increase the contact area between the seat and theuser. This fact contributes to minimise the local pressuresthat can generate problems like decubitus ulcers. Thepresent research aims at establishing development routesfor custom cushion production to wheelchair users. Thisstudy also contributes to the investigation of ComputerNumerical Control (CNC machining of flexible polyurethanefoams.MethodThe proposed route to obtain the customised seat beganwith acquiring the user’s contour in adequate posturethrough plaster cast. To collect the surface geometry, thecast was three-dimensionally scanned and manipulated inCAD/CAM software. CNC milling parameters such as tools,spindle speeds and feed rates to machine flexiblepolyurethane foams were tested. These parameters wereanalysed regarding the surface quality. The best parameterswere then tested in a customised seat. The possibledimensional changes generated during foam cutting wereanalysed through 3D scanning. Also, the customised seatpressure and temperature distribution was tested.ResultsThe best parameters found for foams with a density of50kg/cm3 were high spindle speeds (24000 rpm and feedrates between 2400–4000mm/min. Those parameters didnot generate significant deformities in the machinedcushions. The custom contoured cushion satisfactorilyincreased the contact area between wheelchair and user, asit distributed pressure and heat evenly.ConclusionThrough this study it was possible to define routes for thedevelopment and manufacturing of customised seats usingdirect CNC milling in flexible polyurethane foams. It alsoshowed that custom contoured cushions efficientlydistribute pressure and temperature, which is believed tominimise tissue lesions such as pressure

  6. Questionnaire survey of customer satisfaction for product categories towards certification of ergonomic quality in design.

    Science.gov (United States)

    Mochimaru, Masaaki; Takahashi, Miwako; Hatakenaka, Nobuko; Horiuchi, Hitoshi

    2012-01-01

    Customer satisfaction was surveyed for 6 product categories (consumer electronics, daily commodities, home equipment, information systems, cars, and health appliances) by questionnaires based on the Analytic Hierarchy Process. Analyzing weight of evaluation factors, the 6 product categories were reorganized into 4 categories, those were related to 4 aspects in daily living that formed by two axes: home living - mobility life and healthy life - active communication. It was found that consumers were attracted by the actual user test by public institutes for all product categories. The certification based on the design process standard established by authorities, such as EQUID was the second best attractor for consumers.

  7. Custom-Designed Molecular Scissors for Site-Specific Manipulation of the Plant and Mammalian Genomes

    Science.gov (United States)

    Kandavelou, Karthikeyan; Chandrasegaran, Srinivasan

    Zinc finger nucleases (ZFNs) are custom-designed molecular scissors, engineered to cut at specific DNA sequences. ZFNs combine the zinc finger proteins (ZFPs) with the nonspecific cleavage domain of the FokI restriction enzyme. The DNA-binding specificity of ZFNs can be easily altered experimentally. This easy manipulation of the ZFN recognition specificity enables one to deliver a targeted double-strand break (DSB) to a genome. The targeted DSB stimulates local gene targeting by several orders of magnitude at that specific cut site via homologous recombination (HR). Thus, ZFNs have become an important experimental tool to make site-specific and permanent alterations to genomes of not only plants and mammals but also of many other organisms. Engineering of custom ZFNs involves many steps. The first step is to identify a ZFN site at or near the chosen chromosomal target within the genome to which ZFNs will bind and cut. The second step is to design and/or select various ZFP combinations that will bind to the chosen target site with high specificity and affinity. The DNA coding sequence for the designed ZFPs are then assembled by polymerase chain reaction (PCR) using oligonucleotides. The third step is to fuse the ZFP constructs to the FokI cleavage domain. The ZFNs are then expressed as proteins by using the rabbit reticulocyte in vitro transcription/translation system and the protein products assayed for their DNA cleavage specificity.

  8. A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates.

    Science.gov (United States)

    Chen, Xiaozhong; He, Kunjin; Chen, Zhengming

    2017-01-01

    The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information.

  9. An Integrated Unix-based CAD System for the Design and Testing of Custom VLSI Chips

    Science.gov (United States)

    Deutsch, L. J.

    1985-01-01

    A computer aided design (CAD) system that is being used at the Jet Propulsion Laboratory for the design of custom and semicustom very large scale integrated (VLSI) chips is described. The system consists of a Digital Equipment Corporation VAX computer with the UNIX operating system and a collection of software tools for the layout, simulation, and verification of microcircuits. Most of these tools were written by the academic community and are, therefore, available to JPL at little or no cost. Some small pieces of software have been written in-house in order to make all the tools interact with each other with a minimal amount of effort on the part of the designer.

  10. A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates

    Science.gov (United States)

    2017-01-01

    The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information. PMID:28203270

  11. Autonomous navigation of a mobile robot using custom-designed qualitative reasoning VLSI chips and boards

    Energy Technology Data Exchange (ETDEWEB)

    Pin, F.G.; Pattay, R.S. (Oak Ridge National Lab., TN (United States)); Watanabe, H.; Symon, J. (North Carolina Univ., Chapel Hill, NC (United States). Dept. of Computer Science)

    1991-01-01

    Two types of computer boards including custom-designed VLSI chips have been developed to add a qualitative reasoning capability to the real-time control of autonomous mobile robots. The design and operation of these boards are first described and an example of their use for the autonomous navigation of a mobile robot is presented. The development of qualitative reasoning schemes emulating human-like navigation is a-priori unknown environments is discussed. The efficiency of such schemes, which can consist of as little as a dozen qualitative rules, is illustrated in experiments involving an autonomous mobile robot navigating on the basis of very sparse inaccurate sensor data. 17 refs., 6 figs.

  12. Using custom-designed VLSI fuzzy inferencing chips for the autonomous navigation of a mobile robot

    Energy Technology Data Exchange (ETDEWEB)

    Pin, F.G.; Pattay, R.S. (Oak Ridge National Lab., TN (United States)); Watanabe, Hiroyuki; Symon, J. (North Carolina Univ., Chapel Hill, NC (United States). Dept. of Computer Science)

    1991-01-01

    Two types of computer boards including custom-designed VLSI fuzzy inferencing chips have been developed to add a qualitative reasoning capability to the real-time control of autonomous mobile robots. The design and operation of these boards are first described and an example of their use for the autonomous navigation of mobile robot is presented. The development of qualitative reasoning schemes emulating human-like navigation in apriori unknown environments is discussed. An approach using superposition of elemental sensor-based behaviors is shown to alloy easy development and testing of the inferencing rule base, while providing for progressive addition of behaviors to resolve situations of increasing complexity. The efficiency of such schemes, which can consist of as little as a dozen qualitative rules, is illustrated in experiments involving an autonomous mobile robot navigating on the basis of very sparse and inaccurate sensor data. 17 refs., 6 figs.

  13. A study on the design system of human sensibility ergonomics for development of a customer-oriented product

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D.G.; Yang, S.M.; Park, J.S.; Lee, S.Y. [Korea University, Seoul (Korea, Republic of)

    1997-05-01

    The human sense is measured and analyzed by physical design factors and can be applied also for the product design. At this point of view, this paper describes the implementation process of Virtual Modeling system for a customer-oriented product. The first step implementing virtual modeling is to make a human sensibility({sup K}ansei{sup )} database -human sensibility database is constructed with the relational data of Kansei words and design factors-. The next step is extraction the design information from the human sensibility database by fuzzy inference algorithm. This design information is used for the input data for the graphic database. Virtual implementation software compounds 3D shape of product. The final product can be modified according to the customer`s requirement. (author). 13 refs., 11 figs.

  14. Advanced engineering tools for design and fabrication of a custom nasal prosthesis

    Science.gov (United States)

    Oliveira, Inês; Leal, Nuno; Silva, Pedro; da Costa Ferreira, A.; Neto, Rui J.; Lino, F. Jorge; Reis, Ana

    2012-09-01

    Unexpected external defects resulting from neoplasms, burns, congenital malformations, trauma or other diseases, particularly when involving partial or total loss of an external organ, can be emotionally devastating. These defects can be restored with prosthesis, obtained by different techniques, materials and methods. The increase of patient numbers and cost constraints lead to the need of exploring new techniques that can increase efficiency. The main goal of this project was to develop a full engineering-based manufacturing process to obtain soft-tissue prosthesis that could provide faster and less expensive options in the manufacturing of customized prosthesis, and at the same time being able to reproduce the highest degree of details, with the maximum comfort for the patient. Design/methodology/approach - This case report describes treatment using silicone prosthesis with an anatomic retention for an 80-years-old woman with a rhinectomy. The proposed methodology integrates non-contact structured light scanning, CT and reverse engineering with CAD/CAM and additive manufacturing technology. Findings - The proposed protocol showed encouraging results since reveals being a better solution for fabricating custom-made facial prostheses for asymmetrical organs than conventional approaches. The process allows the attainment of prosthesis with the minimum contact and discomfort for the patient, disclosing excellent results in terms of aesthetic, prosthesis retention and in terms of time and resources consumed.

  15. Design of RSFQ wave pipelined Kogge-Stone Adder and developing custom compound gates

    Science.gov (United States)

    Ozer, M.; Eren Çelik, M.; Tukel, Y.; Bozbey, A.

    2014-09-01

    Since the invention of computers, the calculation of arithmetic and logic operations using digital circuits has been one of the leading problems in processor designs. The challenge has been to compute more operations with less clock cycles by using additional specific logic circuits. One of the most fundamental processes is addition; in which the carry bit should be transferred from the least significant bit to the most significant one. A wide range of digital circuit designs have been sustained for specialized faster addition operation. One of these adder algorithms is Kogge Stone Adder which does faster calculation with fewer levels and minimum fan-out compared to today’s adders despite the only disadvantage of having an excessive amount of wiring. In this study, a custom Rapid Single Flux Quantum (RSFQ) based, wave pipelined, Kogge Stone Adder is proposed to be used later in an Arithmetic Logic Unit (ALU). Two different design methodologies have been considered. In the first approach, we used standard logic gates for the whole adder design. In the second approach, utilization to compound gate design with adjustments over component parameters is done by using Particle Swarm Optimization and Statistical Timing Analysis Tools, to increase both efficiency and bias margin.

  16. A study on the design, formulation and effectiveness of chewing gums containing Chlorhexidine Gluconate in the prevention of dental plaque

    Directory of Open Access Journals (Sweden)

    Kolahi Kazerani G

    2003-08-01

    Full Text Available Statement of Problem: The role of the microbial plaque in caries etiology and periodontal diseases has been"nproved and the mechanical methods for plaque control have special limitations, consequently, chemical"nmethods have been suggested. One of the most effective materials is Chlorhexidine Gluconate that is"ncommonly used as mouth rinses. However, the medicated formulations of chewing gums, due to several"nproperties, have been paid attention. It should be noted that a new formulation to satisfy the consumers' taste"nseems necessary."nPurpose: The aim of this study was to present a new formulation for chewing gums containing chlorhexidine"nto achieve a pleasant taste coupled with their effectiveness and anti-plaque properties maintenance."nMaterials and Methods: In this double blind, crossover, prospective clinical trial, 18 volunteers were"ninvestigated. Chlorhexidine Gluconate was used and added to the gum-base by Manitole. In order to cover the"nbitter taste of the drug Aspartam, mint essence and Mentole were used. After gums production, the profile of"ndrug dissolution was evaluated by jaw movement simulating system. It took 5 days to study each type of"nchewing gums without any mechanical plaque control method. Medicated and placebo chewing gums were"nidentical in shape, size, color and formulation. The washout period was 2 days. Chewing gums were used"nevery 12 hours for 20 minutes. To determine plaque score, Turesky- Gilmore- Glickman modification index"nwas used. Other variables including: subjective evaluation of taste, cleansing effect and taste disturbance were"nassessed through filling a checklist. The data were analyzed by Paired t test and Wilcoxon test."nResults: During 20 mins, 80% of the drug was released from the gum-base. The mean difference of plaque"nscore between the initial and final stages at the first trial was -0.1589 and at the second trial was 2.994 which"nwas statistically significant (P<0.001. Subjective

  17. Custom-designed mouthpiece for HDR brachytherapy of embryonal rhabdomyosarcoma of the soft palate.

    Science.gov (United States)

    Ekwelundu, Emmanuel; Krasin, Matthew J; Farr, Jonathan B

    2014-10-01

    This paper describes the design and fabrication of the mouthpiece used for high-dose-rate (HDR) brachytherapy of a cancerous lesion in the soft palate of a pediatric patient. A custom mouth guard made with Thermo-forming material (Clear - Mouthguard) similar to those used by athletes, with a bite section, alveolar sulcus, hard and soft palate sections was made. Markers were placed around the lesion using a color transfer applicator and the impression transferred to the mouthpiece. Ten catheters arranged in a plane were placed on the inferior side (concave part) of the mouthpiece, and held in place by stitching each to the mouthpiece. Two pieces of lead (Pb) sheets with total thickness of 5.7 mm were placed beneath the catheters. Wax was used to create additional distance between the tongue and the catheters, and the entire assembly was covered with wax.

  18. 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems.

    Science.gov (United States)

    Jonathan, Goole; Karim, Amighi

    2016-02-29

    Three-dimensional printing includes a wide variety of manufacturing techniques, which are all based on digitally-controlled depositing of materials (layer-by-layer) to create freeform geometries. Therefore, three-dimensional printing processes are commonly associated with freeform fabrication techniques. For years, these methods were extensively used in the field of biomanufacturing (especially for bone and tissue engineering) to produce sophisticated and tailor-made scaffolds from patient scans. This paper aims to review the processes that can be used in pharmaceutics, including the parameters to be controlled. In practice, it not straightforward for a formulator to be aware of the various technical advances made in this field, which is gaining more and more interest. Thus, a particular aim of this review is to give an overview on the pragmatic tools, which can be used for designing customized drug delivery systems using 3D printing.

  19. Customer Focused Product Design Using Integrated Model of Target Costing, Quality Function Deployment and Value Engineering

    Directory of Open Access Journals (Sweden)

    Hossein Rezaei Dolatabadi

    2013-01-01

    Full Text Available Target costing by integrating customer requirements, technical attributes and cost information into the product design phase and eliminating the non-value added functions, plays a vital role in different phases of the product life cycle. Quality Function Deployment (QFD and Value Engineering (VE are two techniques which can be used for applying target costing, successfully. The purpose of this paper is to propose an integrated model of target costing, QFD and VE to explore the role of target costing in managing product costs while promoting quality specifications meeting customers’ needs. F indings indicate that the integration of target costing, QFD and VE is an essential technique in managing the costs of production process. Findings also imply that integration of the three techniques provides a competitive cost advantage to companies.

  20. Design and implementation of a custom built optical projection tomography system.

    Science.gov (United States)

    Wong, Michael D; Dazai, Jun; Walls, Johnathon R; Gale, Nicholas W; Henkelman, R Mark

    2013-01-01

    Optical projection tomography (OPT) is an imaging modality that has, in the last decade, answered numerous biological questions owing to its ability to view gene expression in 3 dimensions (3D) at high resolution for samples up to several cm(3). This has increased demand for a cabinet OPT system, especially for mouse embryo phenotyping, for which OPT was primarily designed for. The Medical Research Council (MRC) Technology group (UK) released a commercial OPT system, constructed by Skyscan, called the Bioptonics OPT 3001 scanner that was installed in a limited number of locations. The Bioptonics system has been discontinued and currently there is no commercial OPT system available. Therefore, a few research institutions have built their own OPT system, choosing parts and a design specific to their biological applications. Some of these custom built OPT systems are preferred over the commercial Bioptonics system, as they provide improved performance based on stable translation and rotation stages and up to date CCD cameras coupled with objective lenses of high numerical aperture, increasing the resolution of the images. Here, we present a detailed description of a custom built OPT system that is robust and easy to build and install. Included is a hardware parts list, instructions for assembly, a description of the acquisition software and a free download site, and methods for calibration. The described OPT system can acquire a full 3D data set in 10 minutes at 6.7 micron isotropic resolution. The presented guide will hopefully increase adoption of OPT throughout the research community, for the OPT system described can be implemented by personnel with minimal expertise in optics or engineering who have access to a machine shop.

  1. Rationale, Design, and Methodological Aspects of the BUDAPEST-GLOBAL Study (Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions).

    Science.gov (United States)

    Maurovich-Horvat, Pál; Tárnoki, Dávid L; Tárnoki, Ádám D; Horváth, Tamás; Jermendy, Ádám L; Kolossváry, Márton; Szilveszter, Bálint; Voros, Viktor; Kovács, Attila; Molnár, Andrea Á; Littvay, Levente; Lamb, Hildo J; Voros, Szilard; Jermendy, György; Merkely, Béla

    2015-12-01

    The heritability of coronary atherosclerotic plaque burden, coronary geometry, and phenotypes associated with increased cardiometabolic risk are largely unknown. The primary aim of the Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions (BUDAPEST-GLOBAL) study is to evaluate the influence of genetic and environmental factors on the burden of coronary artery disease. By design this is a prospective, single-center, classical twin study. In total, 202 twins (61 monozygotic pairs, 40 dizygotic same-sex pairs) were enrolled from the Hungarian Twin Registry database. All twins underwent non-contrast-enhanced computed tomography (CT) for the detection and quantification of coronary artery calcium and for the measurement of epicardial fat volumes. In addition, a single non-contrast-enhanced image slice was acquired at the level of L3-L4 to assess abdominal fat distribution. Coronary CT angiography was used for the detection and quantification of plaque, stenosis, and overall coronary artery disease burden. For the primary analysis, we will assess the presence and volume of atherosclerotic plaques. Furthermore, the 3-dimensional coronary geometry will be assessed based on the coronary CT angiography datasets. Additional phenotypic analyses will include per-patient epicardial and abdominal fat quantity measurements. Measurements obtained from monozygotic and dizygotic twin pairs will be compared to evaluate the genetic or environmental effects of the given phenotype. The BUDAPEST-GLOBAL study provides a unique framework to shed some light on the genetic and environmental influences of cardiometabolic disorders. © 2015 Wiley Periodicals, Inc.

  2. A custom-built PET phantom design for quantitative imaging of printed distributions

    Energy Technology Data Exchange (ETDEWEB)

    Markiewicz, P J; Angelis, G I; Kotasidis, F; Green, M; Matthews, J C [School of Cancer and Enabling Sciences, MAHSC, University of Manchester, Wolfson Molecular Imaging Centre, Manchester (United Kingdom); Lionheart, W R [School of Mathematics, Alan Turing Building, The University of Manchester (United Kingdom); Reader, A J, E-mail: p.markiewicz@manchester.ac.uk [Montreal Neurological Institute, McGill University, Montreal (Canada)

    2011-11-07

    This note presents a practical approach to a custom-made design of PET phantoms enabling the use of digital radioactive distributions with high quantitative accuracy and spatial resolution. The phantom design allows planar sources of any radioactivity distribution to be imaged in transaxial and axial (sagittal or coronal) planes. Although the design presented here is specially adapted to the high-resolution research tomograph (HRRT), the presented methods can be adapted to almost any PET scanner. Although the presented phantom design has many advantages, a number of practical issues had to be overcome such as positioning of the printed source, calibration, uniformity and reproducibility of printing. A well counter (WC) was used in the calibration procedure to find the nonlinear relationship between digital voxel intensities and the actual measured radioactive concentrations. Repeated printing together with WC measurements and computed radiography (CR) using phosphor imaging plates (IP) were used to evaluate the reproducibility and uniformity of such printing. Results show satisfactory printing uniformity and reproducibility; however, calibration is dependent on the printing mode and the physical state of the cartridge. As a demonstration of the utility of using printed phantoms, the image resolution and quantitative accuracy of reconstructed HRRT images are assessed. There is very good quantitative agreement in the calibration procedure between HRRT, CR and WC measurements. However, the high resolution of CR and its quantitative accuracy supported by WC measurements made it possible to show the degraded resolution of HRRT brain images caused by the partial-volume effect and the limits of iterative image reconstruction. (note)

  3. Periodontal pathogens in atheromatous plaque

    Directory of Open Access Journals (Sweden)

    Saroj K. Rath

    2014-01-01

    Full Text Available Background: There has been increasing attention paid in recent years to the possibility that oral bacterial infection, particularly periodontal disease may influence the initiation and or progression of systemic diseases. These studies confirm the observation that heart disease is the most commonly found systemic condition in patients with periodontal disease. Moreover, the literature has also highlighted substantial evidence indicating the presence of Gram-negative periodontal pathogens in atheromatous plaques. Aim: This study intends to investigate the possible association between periodontal health and coronary artery disease by evaluating periodontal status, association between the periodontal plaque and coronary atheromatous plaques for presence of micro-organisms such as, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, and Tannerella forsythia. Materials and methods: A case-control study was designed with seven patients who had undergone coronary endarterectomy for cardiovascular disease and 28 controls. The periodontal examination for cases was performed 1 day before vascular surgery and the controls were clinically examined. The atheromatous plaque sample collected during endarterectomy and the intraoral plaque samples were subjected to polymerase chain reaction for identification of A. actinomycetemcomitans, P. gingivalis, P. intermedia and T. forsythia. Results: The presence of periodontal bacteria DNA in coronary atheromatous plaques and sub-gingival plaque samples of the same patients was confirmed by this study. CONCLUSION A correlation was established between putative bacteria contributing to atheromatous plaques and species associated with periodontal disease. One particularly important study to be carried out is the investigation of a possible clinically meaningful reduction in coronary heart disease resulting from the prevention or treatment of periodontal disease.

  4. Establishing Customer Requirements: An Instructional Analysis for Continuous Quality Improvement Training Design.

    Science.gov (United States)

    Gallagher, Jo D.

    Establishing customer requirements spans two steps in the planning for quality set forth by Juran (1988), those of discovering customer needs and expectations and translating them into the language of those responsible for meeting the needs. The need for training was documented in a large, decentralized service organization through qualitative…

  5. SU-E-T-443: Geometric Uncertainties in Eye Plaque Dosimetry for a Fully Loaded 16 Mm COMS Plaque

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, H; Menon, G; Jans, H; Larocque, M; Sloboda, R [Cross Cancer Institute, Edmonton, AB, and University of Alberta, Edmonton, AB (Canada)

    2015-06-15

    Purpose: To determine the effect of geometric uncertainties in the seed positions in a COMS eye plaque on the central axis (CAX) dose. Methods: A Silastic insert was placed into a photopolymer 3D printed 16 mm COMS plaque, which was then positioned onto a custom-designed PMMA eye phantom. High resolution 3D images were acquired of the setup using a Siemens Inveon microPET/CT scanner. Images were acquired with the plaque unloaded and loaded with IsoAid I-125 seed shells (lack of silver core to minimize metal artifacts). Seed positions and Silastic thickness beneath each slot were measured. The measured seed coordinates were used to alter the seed positions within a standard 16 mm COMS plaque in Plaque Simulator v5.7.3 software. Doses along the plaque CAX were compared for the original and modified plaque coordinates using 3.5 mCi seeds with treatment times set to deliver 70 Gy to tumour apexes of 3.5, 5, and 10 mm height. Results: The majority of seeds showed length-wise displacement, and all seeds showed displacement radially outward from the eye center. The average radial displacement was 0.15 mm larger than the expected 1.4 mm offset, approximately half of which was due to increased Silastic thickness beneath each slot. The CAX doses for the modified seed positions were consistently lower for all tumour heights due to geometric displacement of the seeds; dose differences were found to increase to a maximum of 2.6% at a depth of ∼10 mm, after which they decreased due to the inverse square dose fall-off minimizing this effect. Conclusion: This work presents initial results of a broader dosimetric uncertainty evaluation for fully loaded COMS eye plaques and demonstrates the effects of seed positioning uncertainties. The small shifts in seed depths had noticeable effects on the CAX doses indicating the importance of careful Silastic loading. Funding provided by Alberta Cancer Foundation Grant #26655, Vanier Canada Graduate Scholarship, and Alberta Innovates Health

  6. Dental implant customization using numerical optimization design and 3-dimensional printing fabrication of zirconia ceramic.

    Science.gov (United States)

    Cheng, Yung-Chang; Lin, Deng-Huei; Jiang, Cho-Pei; Lin, Yuan-Min

    2017-05-01

    This study proposes a new methodology for dental implant customization consisting of numerical geometric optimization and 3-dimensional printing fabrication of zirconia ceramic. In the numerical modeling, exogenous factors for implant shape include the thread pitch, thread depth, maximal diameter of implant neck, and body size. Endogenous factors are bone density, cortical bone thickness, and non-osseointegration. An integration procedure, including uniform design method, Kriging interpolation and genetic algorithm, is applied to optimize the geometry of dental implants. The threshold of minimal micromotion for optimization evaluation was 100 μm. The optimized model is imported to the 3-dimensional slurry printer to fabricate the zirconia green body (powder is bonded by polymer weakly) of the implant. The sintered implant is obtained using a 2-stage sintering process. Twelve models are constructed according to uniform design method and simulated the micromotion behavior using finite element modeling. The result of uniform design models yields a set of exogenous factors that can provide the minimal micromotion (30.61 μm), as a suitable model. Kriging interpolation and genetic algorithm modified the exogenous factor of the suitable model, resulting in 27.11 μm as an optimization model. Experimental results show that the 3-dimensional slurry printer successfully fabricated the green body of the optimization model, but the accuracy of sintered part still needs to be improved. In addition, the scanning electron microscopy morphology is a stabilized t-phase microstructure, and the average compressive strength of the sintered part is 632.1 MPa. Copyright © 2016 John Wiley & Sons, Ltd.

  7. Designing and Explaining the Model of Persistent Customer Loyalty in e-Commerce: A Study in the e-Retailer’s Web Sites

    Directory of Open Access Journals (Sweden)

    mohammad reza hamidizadeh

    2011-09-01

    While the importance of customer loyalty has been recognized in marketing literature for several decades, the design and explanation of persistent customer loyalty and its antecedents in electronic commerce especially in an e-retailing context have not been addressed. Therefore, the aim of this study is to develop and validate such antecedents of persistent loyalty and to propose a comprehensive model. For this purpose, based on e-commerce and marketing literature, a comprehensive set of constructs have been designed and examined on 211 customers of e-retailers using path analysis. The findings imply that persistent customer loyalty has been influenced significantly by all of the recognized factors including trust, payment security, perceived value, customer satisfaction, customization, purchase convenience, brand character, and contact interactivity. Also, customer satisfaction and trust have mediator role in the model.

  8. Using customer-focused research and design to build a self-service online store: a case study

    Directory of Open Access Journals (Sweden)

    Ahmadi MB

    2013-02-01

    Full Text Available Michael B Ahmadi,1 William Trefzger,2 Rich Morey,1 Ileana Quintas31Substance Abuse and Mental Health Services Administration, Rockville, 2Centers for Medicare and Medicaid Services, Baltimore, 3IQ Solutions, Inc, Rockville, MD, USAAbstract: American government information centers need to be responsive to an increasingly customer driven information environment while ensuring the sustainability of operations. Enhanced self-service options offer one avenue for addressing both of these needs. This article presents a case study of how the US Substance Abuse and Mental Health Services Administration used extensive stakeholder research and a customer-centric design to reframe its service model by building a self-service online store that integrates access to more than 1300 behavioral health publications previously housed in two separate clearinghouses. The redesigned Substance Abuse and Mental Health Services Administration Store offers users a modern e-commerce website that not only helps customers find, order, download, and share products, but also encourages serendipitous content exploration, which has led to increased orders containing both substance abuse and mental health publications.Keywords: customer research, taxonomy, usability testing, web analytics, web design

  9. Driving a car with custom-designed fuzzy inferencing VLSI chips and boards

    Science.gov (United States)

    Pin, Francois G.; Watanabe, Yutaka

    1993-01-01

    Vehicle control in a-priori unknown, unpredictable, and dynamic environments requires many calculational and reasoning schemes to operate on the basis of very imprecise, incomplete, or unreliable data. For such systems, in which all the uncertainties can not be engineered away, approximate reasoning may provide an alternative to the complexity and computational requirements of conventional uncertainty analysis and propagation techniques. Two types of computer boards including custom-designed VLSI chips were developed to add a fuzzy inferencing capability to real-time control systems. All inferencing rules on a chip are processed in parallel, allowing execution of the entire rule base in about 30 microseconds, and therefore, making control of 'reflex-type' of motions envisionable. The use of these boards and the approach using superposition of elemental sensor-based behaviors for the development of qualitative reasoning schemes emulating human-like navigation in a-priori unknown environments are first discussed. Then how the human-like navigation scheme implemented on one of the qualitative inferencing boards was installed on a test-bed platform to investigate two control modes for driving a car in a-priori unknown environments on the basis of sparse and imprecise sensor data is described. In the first mode, the car navigates fully autonomously, while in the second mode, the system acts as a driver's aid providing the driver with linguistic (fuzzy) commands to turn left or right and speed up or slow down depending on the obstacles perceived by the sensors. Experiments with both modes of control are described in which the system uses only three acoustic range (sonar) sensor channels to perceive the environment. Simulation results as well as indoors and outdoors experiments are presented and discussed to illustrate the feasibility and robustness of autonomous navigation and/or safety enhancing driver's aid using the new fuzzy inferencing hardware system and some human

  10. Experimental evolution in silico: a custom-designed mathematical model for virulence evolution of Bacillus thuringiensis.

    Science.gov (United States)

    Strauß, Jakob Friedrich; Crain, Philip; Schulenburg, Hinrich; Telschow, Arndt

    2016-08-01

    Most mathematical models on the evolution of virulence are based on epidemiological models that assume parasite transmission follows the mass action principle. In experimental evolution, however, mass action is often violated due to controlled infection protocols. This "theory-experiment mismatch" raises the question whether there is a need for new mathematical models to accommodate the particular characteristics of experimental evolution. Here, we explore the experimental evolution model system of Bacillus thuringiensis as a parasite and Caenorhabditis elegans as a host. Recent experimental studies with strict control of parasite transmission revealed that one-sided adaptation of B. thuringiensis with non-evolving hosts selects for intermediate or no virulence, sometimes coupled with parasite extinction. In contrast, host-parasite coevolution selects for high virulence and for hosts with strong resistance against B. thuringiensis. In order to explain the empirical results, we propose a new mathematical model that mimics the basic experimental set-up. The key assumptions are: (i) controlled parasite transmission (no mass action), (ii) discrete host generations, and (iii) context-dependent cost of toxin production. Our model analysis revealed the same basic trends as found in the experiments. Especially, we could show that resistant hosts select for highly virulent bacterial strains. Moreover, we found (i) that the evolved level of virulence is independent of the initial level of virulence, and (ii) that the average amount of bacteria ingested significantly affects the evolution of virulence with fewer bacteria ingested selecting for highly virulent strains. These predictions can be tested in future experiments. This study highlights the usefulness of custom-designed mathematical models in the analysis and interpretation of empirical results from experimental evolution.

  11. The Impact of Rate Design and Net Metering on the Bill Savings from Distributed PV for Residential Customers in California

    Energy Technology Data Exchange (ETDEWEB)

    Darghouth, Naim; Barbose, Galen; Wiser, Ryan

    2010-03-30

    Net metering has become a widespread policy in the U.S. for supporting distributed photovoltaics (PV) adoption. Though specific design details vary, net metering allows customers with PV to reduce their electric bills by offsetting their consumption with PV generation, independent of the timing of the generation relative to consumption - in effect, compensating the PV generation at retail electricity rates (Rose et al. 2009). While net metering has played an important role in jump-starting the residential PV market in the U.S., challenges to net metering policies have emerged in a number of states and contexts, and alternative compensation methods are under consideration. Moreover, one inherent feature of net metering is that the value of the utility bill savings it provides to customers with PV depends heavily on the structure of the underlying retail electricity rate, as well as on the characteristics of the customer and PV system. Consequently, the value of net metering - and the impact of moving to alternative compensation mechanisms - can vary substantially from one customer to the next. For these reasons, it is important for policymakers and others that seek to support the development of distributed PV to understand both how the bill savings varies under net metering, and how the bill savings under net metering compares to other possible compensation mechanisms. To advance this understanding, we analyze the bill savings from PV for residential customers of California's two largest electric utilities, Pacific Gas and Electric (PG&E) and Southern California Edison (SCE). The analysis is based on hourly load data from a sample of 215 residential customers located in the service territories of the two utilities, matched with simulated hourly PV production for the same time period based on data from the nearest of 73 weather stations in the state.

  12. Design and health care: a study of virtual design and direct metal lasersintering of titanium alloy for the production of customized facial implants

    Directory of Open Access Journals (Sweden)

    Wilson Kindlein Junior

    2009-11-01

    Full Text Available The increase in life expectancy and a great number ofaccidents lead to higher demand for medical products,including corrective implants. Patients with tumors or traumas need to replace injured areas in order to restore their aesthetic and structural function. Currently, the available craniofacial implants present a standard geometry and seldom generate satisfactory results. Customized implants, on theother hand, are designed to conform exactly to individual patient’s anatomy. This way, the use of customized implantscan show beneficial effects to the patient and the surgicalteam. In this study, the design and manufacturing of customized implant prior to surgery were described. Implant shape and functional requirements were established by digitaldata based on CT-scans and mirroring operations. The designprocess of customized mandible prosthesis is illustrated as well as its manufacturing process (direct metal laser sinteringand quality control. Laser sintering process and its constraints for the production of customized implants in titanium alloy(Ti-6Al-4V with complex geometry and internal structures are reported.

  13. Identifying smart design attributes for Industry 4.0 customization using a clustering Genetic Algorithm

    OpenAIRE

    Flores Saldivar, Alfredo; Goh, Cindy SF; Li, Yun; Chen, Yi; Yu, Hongnian

    2016-01-01

    Industry 4.0 aims at achieving mass customization at a\\ud mass production cost. A key component to realizing this is accurate\\ud prediction of customer needs and wants, which is however a\\ud challenging issue due to the lack of smart analytics tools. This\\ud paper investigates this issue in depth and then develops a predictive\\ud analytic framework for integrating cloud computing, big data\\ud analysis, business informatics, communication technologies, and\\ud digital industrial production syst...

  14. Reevaluation of the AAPM TG-43 brachytherapy dosimetry parameters for an 125I seed, and the influence of eye plaque design on dose distributions and dose-volume histograms

    Science.gov (United States)

    Aryal, Prakash

    The TG-43 dosimetry parameters of the Advantage(TM) 125I model IAI-125A brachytherapy seed were studied. An investigation using modern MCNP radiation transport code with updated cross-section libraries was performed. Twelve different simulation conditions were studied for a single seed by varying the coating thickness, mass density, photon energy spectrum and cross-section library. The dose rate was found to be 6.3% lower at 1 cm in comparison to published results. New TG-43 dosimetry parameters are proposed. The dose distribution for a brachytherapy eye plaque, model EP917, was investigated, including the effects of collimation from high-Z slots. Dose distributions for 26 slot designs were determined using Monte Carlo methods and compared between the published literature, a clinical treatment planning system, and physical measurements. The dosimetric effect of the composition and mass density of the gold backing was shown to be less than 3%. Slot depth, width, and length changed the central axis (CAX) dose distributions by < 1% per 0.1 mm in design variation. Seed shifts in the slot towards the eye and shifts of the 125I-laden silver rod within the seed had the greatest impact on the CAX dose distribution, changing it by 14%, 9%, 4.3%, and 2.7% at 1, 2, 5, and 10 mm, respectively, from the inner scleral surface. The measured, full plaque slot geometry delivered 2.4% +/- 1.1% higher dose along the plaque's CAX than the geometry provided by the manufacturer and 2.2%+/-2.3% higher than Plaque Simulator(TM) (PS) treatment planning software (version 5.7.6). The D10 for the simulated tumor, inner sclera, and outer sclera for the measured slot plaque to manufacturer provided slot design was 9%, 10%, and 19% higher, respectively. In comparison to the measured plaque design, a theoretical plaque having narrow and deep slots delivered 30%, 37%, and 62% lower D 10 doses to the tumor, inner sclera, and outer sclera, respectively. CAX doses at --1, 0, 1, and 2 mm were also

  15. Design factors: the impact of facility aesthetics and layout accessibility on customers' emotions and behavioral intentions in hotel lobbies

    OpenAIRE

    Şahiner, Fulden

    2016-01-01

    Cataloged from PDF version of article. Includes bibliographical references (leaves 84-94). Thesis (M.S.): Bilkent University, Department of Interior Architecture and Environmental Design, İhsan Doğramacı Bilkent University, 2016. The aim of the study is to emphasis the effect of physical environment of interior space on customer's emotions and behavioral intentions at hotel lobbies. Relevant literature in environmental psychology and marketing was reviewed, and conceptual sc...

  16. Combination of surgical excision and custom designed silicon pressure splint therapy for keloids on the helical rim

    Directory of Open Access Journals (Sweden)

    Altmeyer Peter

    2007-03-01

    Full Text Available Abstract Keloids are defined as dermal fibrotic lesions which are considered an aberration of the wound healing process. Their etiology and pathogenesis are poorly understood. Different treatment modalities are described in the literature depending on the morphology and size of the keloid. We report a case of a large ear keloid on the helical rim which was successfully treated with surgery and a custom designed silicon pressure clip.

  17. Mass Customization Measurements Metrics

    DEFF Research Database (Denmark)

    Nielsen, Kjeld; Brunø, Thomas Ditlev; Jørgensen, Kaj Asbjørn

    2014-01-01

    A recent survey has indicated that 17 % of companies have ceased mass customizing less than 1 year after initiating the effort. This paper presents measurement for a company’s mass customization performance, utilizing metrics within the three fundamental capabilities: robust process design, choice...... navigation, and solution space development. A mass customizer when assessing performance with these metrics can identify within which areas improvement would increase competitiveness the most and enable more efficient transition to mass customization....

  18. Variation-Aware Design of Custom Integrated Circuits A Hands-on Field Guide A Hands-on Field Guide

    CERN Document Server

    McConaghy, Trent; Dyck, Jeffrey; Gupta, Amit

    2013-01-01

    This book targets custom IC designers who are encountering variation issues in their designs, especially for modern process nodes at 45nm and below, such as statistical process variations, environmental variations, and layout effects.  The authors have created a field guide to show how to handle variation proactively, and to understand the benefits of doing so. Readers facing variation challenges in their memory, standard cell, analog/RF, and custom digital designs will find easy-to-read, pragmatic solutions.   Reviews the most important concepts in variation-aware design, including types of variables and variation, useful variation-aware design terminology, and an overview and comparison of high-level design flows. Describes and compares a suite of approaches and flows for PVT corner-driven design and verification. Presents Fast PVT, a novel, confidence-driven global optimization technique for PVT corner extraction and verification that is both rapid and reliable. Presents a visually-oriented overview of ...

  19. New layer-based imaging and rapid prototyping techniques for computer-aided design and manufacture of custom dental restoration.

    Science.gov (United States)

    Lee, M-Y; Chang, C-C; Ku, Y C

    2008-01-01

    Fixed dental restoration by conventional methods greatly relies on the skill and experience of the dental technician. The quality and accuracy of the final product depends mostly on the technician's subjective judgment. In addition, the traditional manual operation involves many complex procedures, and is a time-consuming and labour-intensive job. Most importantly, no quantitative design and manufacturing information is preserved for future retrieval. In this paper, a new device for scanning the dental profile and reconstructing 3D digital information of a dental model based on a layer-based imaging technique, called abrasive computer tomography (ACT) was designed in-house and proposed for the design of custom dental restoration. The fixed partial dental restoration was then produced by rapid prototyping (RP) and computer numerical control (CNC) machining methods based on the ACT scanned digital information. A force feedback sculptor (FreeForm system, Sensible Technologies, Inc., Cambridge MA, USA), which comprises 3D Touch technology, was applied to modify the morphology and design of the fixed dental restoration. In addition, a comparison of conventional manual operation and digital manufacture using both RP and CNC machining technologies for fixed dental restoration production is presented. Finally, a digital custom fixed restoration manufacturing protocol integrating proposed layer-based dental profile scanning, computer-aided design, 3D force feedback feature modification and advanced fixed restoration manufacturing techniques is illustrated. The proposed method provides solid evidence that computer-aided design and manufacturing technologies may become a new avenue for custom-made fixed restoration design, analysis, and production in the 21st century.

  20. Challenges and opportunities in multichannel customer management

    NARCIS (Netherlands)

    Neslin, Scott A.; Grewal, Dhruv; Leghorn, Robert; Shankar, Venkatesh; Teerling, Marije L.; Thomas, Jacquelyn S.; Verhoef, Peter C.

    2006-01-01

    Multichannel customer management is the design, deployment, coordination, and evaluation of channels through which firms and customers interact, with the goal of enhancing customer value through effective customer acquisition, retention, and development. The authors identify five major challenges pr

  1. Challenges and opportunities in multichannel customer management

    NARCIS (Netherlands)

    Neslin, Scott A.; Grewal, Dhruv; Leghorn, Robert; Shankar, Venkatesh; Teerling, Marije L.; Thomas, Jacquelyn S.; Verhoef, Peter C.

    2006-01-01

    Multichannel customer management is the design, deployment, coordination, and evaluation of channels through which firms and customers interact, with the goal of enhancing customer value through effective customer acquisition, retention, and development. The authors identify five major challenges

  2. Challenges and opportunities in multichannel customer management

    NARCIS (Netherlands)

    Neslin, Scott A.; Grewal, Dhruv; Leghorn, Robert; Shankar, Venkatesh; Teerling, Marije L.; Thomas, Jacquelyn S.; Verhoef, Peter C.

    2006-01-01

    Multichannel customer management is the design, deployment, coordination, and evaluation of channels through which firms and customers interact, with the goal of enhancing customer value through effective customer acquisition, retention, and development. The authors identify five major challenges pr

  3. Full-custom design of split-set data weighted averaging with output register for jitter suppression

    Science.gov (United States)

    Jubay, M. C.; Gerasta, O. J.

    2015-06-01

    A full-custom design of an element selection algorithm, named as Split-set Data Weighted Averaging (SDWA) is implemented in 90nm CMOS Technology Synopsys Library. SDWA is applied in seven unit elements (3-bit) using a thermometer-coded input. Split-set DWA is an improved DWA algorithm which caters the requirement for randomization along with long-term equal element usage. Randomization and equal element-usage improve the spectral response of the unit elements due to higher Spurious-free dynamic range (SFDR) and without significantly degrading signal-to-noise ratio (SNR). Since a full-custom, the design is brought to transistor-level and the chip custom layout is also provided, having a total area of 0.3mm2, a power consumption of 0.566 mW, and simulated at 50MHz clock frequency. On this implementation, SDWA is successfully derived and improved by introducing a register at the output that suppresses the jitter introduced at the final stage due to switching loops and successive delays.

  4. A comprehensive custom panel design for routine hereditary cancer testing: preserving control, improving diagnostics and revealing a complex variation landscape.

    Science.gov (United States)

    Castellanos, Elisabeth; Gel, Bernat; Rosas, Inma; Tornero, Eva; Santín, Sheila; Pluvinet, Raquel; Velasco, Juan; Sumoy, Lauro; Del Valle, Jesús; Perucho, Manuel; Blanco, Ignacio; Navarro, Matilde; Brunet, Joan; Pineda, Marta; Feliubadaló, Lidia; Capellá, Gabi; Lázaro, Conxi; Serra, Eduard

    2017-01-04

    We wanted to implement an NGS strategy to globally analyze hereditary cancer with diagnostic quality while retaining the same degree of understanding and control we had in pre-NGS strategies. To do this, we developed the I2HCP panel, a custom bait library covering 122 hereditary cancer genes. We improved bait design, tested different NGS platforms and created a clinically driven custom data analysis pipeline. The I2HCP panel was developed using a training set of hereditary colorectal cancer, hereditary breast and ovarian cancer and neurofibromatosis patients and reached an accuracy, analytical sensitivity and specificity greater than 99%, which was maintained in a validation set. I2HCP changed our diagnostic approach, involving clinicians and a genetic diagnostics team from panel design to reporting. The new strategy improved diagnostic sensitivity, solved uncertain clinical diagnoses and identified mutations in new genes. We assessed the genetic variation in the complete set of hereditary cancer genes, revealing a complex variation landscape that coexists with the disease-causing mutation. We developed, validated and implemented a custom NGS-based strategy for hereditary cancer diagnostics that improved our previous workflows. Additionally, the existence of a rich genetic variation in hereditary cancer genes favors the use of this panel to investigate their role in cancer risk.

  5. Smart Product Design and Production Control for Effective Mass Customization in the Industry 4.0 Concept

    Directory of Open Access Journals (Sweden)

    Zawadzki Przemysław

    2016-09-01

    Full Text Available The paper presents a general concept of smart design and production control as key elements for efficient operation of a smart factory. The authors present various techniques that aid the design process of individualized products and organization of their production in the context of realization of the mass customization strategy, which allows a shortened time of development for a new product. Particular attention was paid to integration of additive manufacturing technologies and virtual reality techniques, which are a base of the so-called hybrid prototyping.

  6. Designing and operationalizing a customized internal evaluation model for cancer treatment support programs.

    Science.gov (United States)

    Moore, Heather K; Preussler, Jaime; Denzen, Ellen M; Payton, Tammy J; Thao, Viengneesee; Murphy, Elizabeth A; Harwood, Eileen

    2014-09-01

    Be The Match® Patient and Health Professional Services (PHPS) supports patients undergoing hematopoietic cell transplant (HCT) and caregivers by providing educational programs and resources. HCT is a potentially curative therapy for blood cancers such as leukemia and lymphoma. To help meet the increasing demand for support services, PHPS implemented a multipronged plan to build and sustain the organization's capacity to conduct evaluation of its programs and resources. To do so, PHPS created and operationalized an internal evaluation model, developed customized resources to help stakeholders incorporate evaluation in program planning, and implemented utilization-focused evaluation for quality improvement. Formal mentorship was also critical in the development of an evidence-based, customized model and navigating inherent challenges throughout the process. Our model can serve as a guide for evaluators on establishing and operationalizing an internal evaluation program. Ultimately, we seek to improve support and education services from the time of diagnosis through survivorship.

  7. Decision Support Using Simulation for Customer-Driven Manufacturing System Design and Operations Planning

    OpenAIRE

    Heilala, Juhani; Montonen, Jari; Jarvinen, Paula; Kivikunnas, Sauli

    2010-01-01

    The chapter is a summary of following national public research projects: "Integrated dynamic simulation model of enterprise for planning of operations", (1997-1999); "Integrated dynamic customer driven production network management using operative simulation" (2000-2001) and "Integrated dynamic electronic production and suppliers control and planning of resources" (2000-2001). Development work was later carried out in the projects "Modelling and simulation of manufacturing systems for value n...

  8. U.S. immigration and customs enforcement : dysfunctional not by design

    OpenAIRE

    Wrona, Philip

    2007-01-01

    CHDS State/Local Critical to the success of the homeland security mission is a robust Department of Homeland Security, Immigration and Customs Enforcement (ICE). During a speech made while signing the Homeland Security Appropriations Act for 2006, President George W. Bush stressed that in order to defend the United States from terrorists and criminals, the borders and interior of the country must be secured and immigration laws enforced. Unique to the authority found in ICE is the respons...

  9. The impact of rate design and net metering on the bill savings from distributed PV for residential customers in California

    Energy Technology Data Exchange (ETDEWEB)

    Darghouth, Naim R., E-mail: ndarghouth@lbl.gov [Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 90R4000, Berkeley, CA 94720 (United States); Energy and Resources Group, 310 Barrows Hall, University of California, Berkeley, CA 94720 (United States); Barbose, Galen; Wiser, Ryan [Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 90R4000, Berkeley, CA 94720 (United States)

    2011-09-15

    Net metering has become a widespread mechanism in the U.S. for supporting customer adoption of distributed photovoltaics (PV), but has faced challenges as PV installations grow to a larger share of generation in a number of states. This paper examines the value of the bill savings that customers receive under net metering, and the associated role of retail rate design, based on a sample of approximately two hundred residential customers of California's two largest electric utilities. We find that the bill savings per kWh of PV electricity generated varies by more than a factor of four across the customers in the sample, which is largely attributable to the inclining block structure of the utilities' residential retail rates. We also compare the bill savings under net metering to that received under three potential alternative compensation mechanisms, based on California's Market Price Referent (MPR). We find that net metering provides significantly greater bill savings than a full MPR-based feed-in tariff, but only modestly greater savings than alternative mechanisms under which hourly or monthly net excess generation is compensated at the MPR rate. - Highlights: > We examine the value of bill savings under net metering to PV owners in California. > Bill savings per kWh of PV generation varies by a factor of four with net metering. The variation is attributable to rate design, the unique inclining block structure. > The median value of bill savings is reduced by 40-67% with MPR feed-in tariff. > The median value of bill savings is reduced by 6-12% with hourly netting.

  10. A Fuzzy Algorithm for understanding the customer's desire. An application designed for textile industry.

    Directory of Open Access Journals (Sweden)

    Fabio Luiz Peres Krykhtine

    2013-06-01

    Full Text Available The paper aims at showing how a textile industry can select from a mix of products, the best products to be produced by using the customer’s point of view. The Fuzzy Algorithm for fashion industry is a tool developed to optimise the production and reduce losses and storage costs in the textile industry environment. As the textile industry has an expressive position as an employment intensive industry around the world, its health can be perceived by the ability of their managers in restricting the production to low costs limits, thus acquiring better sales and value to the products. The supply chain management must apply innovations and tools that can deal with these paradigms with dexterity. In a global source operation, the information that one product will be very well accepted by a group of customers with a given price is very welcome. In a sustainability scenario, the algorithm can promote savings in many factors such as: labour, electric energy, water and many other resources spent by the textile industries that have significant impact in economy and environment. Finally, this paper shows a different view to understand the customer's desire through linguistic variable processed in a Fuzzy Logic algorithm. The tool yields an index to the product and find out in a mix of products, which of them will be better accepted by the final customer. Keywords: Fuzzy Logic, Textile Industry, Production Optimization.

  11. Design and application of reconfigurable manufacturing systems in agile mass customization manufacturing environment.

    CSIR Research Space (South Africa)

    Xing, B

    2007-05-01

    Full Text Available manufacturers to move to MCM sooner than later. 3.2 RMS for MCM There are many challenges for MCM, the followings are important: 1) keeping costs low to match those of standardized items, 2) achieve high quality production of high variety of products, 3... is expected to have enough reconfigurablity to respond to small batches of customer demand. Because the construction of any new production line is a large investment, current production lines must be able to be reconfigured to keep up with increased...

  12. Design and health care: a study of virtual design and direct metal lasersintering of titanium alloy for the production of customized facial implants

    OpenAIRE

    2009-01-01

    The increase in life expectancy and a great number ofaccidents lead to higher demand for medical products,including corrective implants. Patients with tumors or traumas need to replace injured areas in order to restore their aesthetic and structural function. Currently, the available craniofacial implants present a standard geometry and seldom generate satisfactory results. Customized implants, on theother hand, are designed to conform exactly to individual patient’s anatomy. This way, the us...

  13. Design of a Customized Multipurpose Nano-Enabled Implantable System for In-Vivo Theranostics

    Directory of Open Access Journals (Sweden)

    Esteve Juanola-Feliu

    2014-10-01

    Full Text Available The first part of this paper reviews the current development and key issues on implantable multi-sensor devices for in vivo theranostics. Afterwards, the authors propose an innovative biomedical multisensory system for in vivo biomarker monitoring that could be suitable for customized theranostics applications. At this point, findings suggest that cross-cutting Key Enabling Technologies (KETs could improve the overall performance of the system given that the convergence of technologies in nanotechnology, biotechnology, micro&nanoelectronics and advanced materials permit the development of new medical devices of small dimensions, using biocompatible materials, and embedding reliable and targeted biosensors, high speed data communication, and even energy autonomy. Therefore, this article deals with new research and market challenges of implantable sensor devices, from the point of view of the pervasive system, and time-to-market. The remote clinical monitoring approach introduced in this paper could be based on an array of biosensors to extract information from the patient. A key contribution of the authors is that the general architecture introduced in this paper would require minor modifications for the final customized bio-implantable medical device.

  14. Dental plaque identification at home

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003426.htm Dental plaque identification at home To use the sharing ... that collects around and between teeth. The home dental plaque identification test shows where plaque builds up. ...

  15. 全定制CORDIC运算器设计%Full Custom CORDIC Arithmetic Unit Design

    Institute of Scientific and Technical Information of China (English)

    毕卓; 戴益君

    2011-01-01

    浮点三角函数计算是导航系统、三维图像处理、雷达信号预处理等领域的基本运算.本文采用CORDIC算法及全定制集成电路设计方法实现了一种浮点三角函数计算电路,其输出数据兼容IEEE-754单精度浮点数标准.本文首先介绍了CORDIC算法的原理,并根据性能优先的原则采用了流水线结构;然后给出了基于SMIC O.13μm 1P8M CMOS工艺下的静态电路结构及版图设计.全定制CORDIC运算器的面积为605 284μm2,最长路径延时(SS条件下)为3.013ns.%Floating-point trigonometric computing is a fundamental operation in navigation systems, 3D image processing, radar signal preprocessing and so on. This paper presents a floating point trigonometric computing circuit using a CORDIC algorithm and a full custom layout method, and the output data are compatible with the IEEE-754 signal precision floating-point standard. It describes the CORDIC algorithm principle and chooses a pipeline structure based on the principle of priority on performance. A static circuit structure and a full custom layout are given in the SIMC 0.13μm 1P8M CMOS process. The silicon area of data path is 605 284/W and the critical path delay is 3.013ns in the SS (Slow-Slow) corners.

  16. Custom-designed AMLCD modules common to multiple platforms from consumer-oriented fabrication facility

    Science.gov (United States)

    Niemczyk, James

    2002-08-01

    The APC- LG-LCD relationship continues to expand with new products developed specifically for APC applications and also LG-LCD products developed for the consumer market, but adapted using APC enhancements for applications in the rugged world. Our delivery performance has proven that a superior, cost effective product can only be produced by incorporating product enhancements at the point of AMLCD manufacture. Further adaptations for specific applications can be simplified by utilizing the same part number panel for multiple platform uses. The manufacturing environment must be flexible enough to run multiple part numbers on a weekly basis. As such, manufacturing automation implemented at APC continues to strengthen our position as the world leader in custom AMLCD display modules. These automation initiatives are the direct result of APC learning the LG-LCD manufacturing method and applying these principals to our particular processes. The APC - LG-LCD relationship affords availability guarantees for display modules for a period of 10 years, thereby reducing procurement risk and minimizing costs associated with redesign when using consumer driven panels. This guarantee redefines the game rules for procurement of AMLCD's. We also offer a very quick turn for those customers who prefer to perform a lifetime buy of product. Typically, thousands of panels can be delivered within six months of a production go ahead. The APC -LC-LCD team remains successful due to the many years spent working together to develop and manufacture products that this niche market demands. The mutual respect for the technical and manufacturing operations at APC and LG-LCD continues to foster a relationship that time and again deliver superior, cost effective products to the market.

  17. Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation

    Directory of Open Access Journals (Sweden)

    Tindall Elizabeth A

    2010-02-01

    Full Text Available Abstract Background High-throughput custom designed genotyping arrays are a valuable resource for biologically focused research studies and increasingly for validation of variation predicted by next-generation sequencing (NGS technologies. We investigate the Illumina GoldenGate chemistry using custom designed VeraCode and sentrix array matrix (SAM assays for each of these applications, respectively. We highlight applications for interpretation of Illumina generated genotype cluster plots to maximise data inclusion and reduce genotyping errors. Findings We illustrate the dramatic effect of outliers in genotype calling and data interpretation, as well as suggest simple means to avoid genotyping errors. Furthermore we present this platform as a successful method for two-cluster rare or non-autosomal variant calling. The success of high-throughput technologies to accurately call rare variants will become an essential feature for future association studies. Finally, we highlight additional advantages of the Illumina GoldenGate chemistry in generating unusually segregated cluster plots that identify potential NGS generated sequencing error resulting from minimal coverage. Conclusions We demonstrate the importance of visually inspecting genotype cluster plots generated by the Illumina software and issue warnings regarding commonly accepted quality control parameters. In addition to suggesting applications to minimise data exclusion, we propose that the Illumina cluster plots may be helpful in identifying potential in-put sequence errors, particularly important for studies to validate NGS generated variation.

  18. A preliminary investigation of user perception and behavioral intention for different review types: customers and designers perspective.

    Science.gov (United States)

    Qazi, Atika; Raj, Ram Gopal; Tahir, Muhammad; Waheed, Mehwish; Waheed, Mahwish; Khan, Saif Ur Rehman; Abraham, Ajith

    2014-01-01

    Existing opinion mining studies have focused on and explored only two types of reviews, that is, regular and comparative. There is a visible gap in determining the useful review types from customers and designers perspective. Based on Technology Acceptance Model (TAM) and statistical measures we examine users' perception about different review types and its effects in terms of behavioral intention towards using online review system. By using sample of users (N = 400) and designers (N = 106), current research work studies three review types, A (regular), B (comparative), and C (suggestive), which are related to perceived usefulness, perceived ease of use, and behavioral intention. The study reveals that positive perception of the use of suggestive reviews improves users' decision making in business intelligence. The results also depict that type C (suggestive reviews) could be considered a new useful review type in addition to other types, A and B.

  19. Turbomachine Sealing and Secondary Flows. Part 1; Review of Sealing Performance, Customer, Engine Designer, and Research Issues

    Science.gov (United States)

    Hendricks, R. C.; Steinetz, B. M.; Braun, M. J.

    2004-01-01

    Although forces outside our control shape our industry, turbomachine sealing research, design, and customer agendas established in 1978 by Ludwig, Campbell, and Smith in terms of specific fuel consumption and performance remain as objectives today. Advances have been made because failures of the space shuttle main engine turbomachinery ushered in a new understanding of sealing in high-power-density systems. Further, it has been shown that changes in sealing, especially for high-pressure rotors, dramatically change the performance of the entire engine or turbomachine. Maintaining seal leakages and secondary flows within engine design specifications remains the most efficient and cost effective way to enhance performance and minimize maintenance costs. This three-part review summarizes experiences, ideas, successes, and failures by NASA and the U.S. aerospace industry in secondary flow management in advanced turbomachinery. Part 1 presents system sealing, part 2 system rotordynamics, and part 3 modeling, with some overlap of each part.

  20. 19 CFR 101.7 - Customs seal.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Customs seal. 101.7 Section 101.7 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY GENERAL PROVISIONS § 101.7 Customs seal. (a) Design. According to the design furnished by the...

  1. Fresh perspectives on customer experience

    OpenAIRE

    McColl-Kennedy, Janet; Gustafsson, Anders; Jaakkola, Elina; Klaus, Phil; Radnor, Zoe; Perks, Helen; Friman, Margareta

    2015-01-01

    Purpose – The purpose is to provide directions for future research on: (1) broadening the role of customers in customer experience; (2) taking a practice-based approach to customer experience; and (3) recognizing the holistic, dynamic nature of customer experience across all touch points and over time. Design/methodology/approach – The approach is conceptual identifying current gaps in research on customer experience. Findings – The findings include a set of research questions and re...

  2. A Patient Specific Biomechanical Analysis of Custom Root Analogue Implant Designs on Alveolar Bone Stress: A Finite Element Study

    Directory of Open Access Journals (Sweden)

    David Anssari Moin

    2016-01-01

    Full Text Available Objectives. The aim of this study was to analyse by means of FEA the influence of 5 custom RAI designs on stress distribution of peri-implant bone and to evaluate the impact on microdisplacement for a specific patient case. Materials and Methods. A 3D surface model of a RAI for the upper right canine was constructed from the cone beam computed tomography data of one patient. Subsequently, five (targeted press-fit design modification FE models with five congruent bone models were designed: “Standard,” “Prism,” “Fins,” “Plug,” and “Bulbs,” respectively. Preprocessor software was applied to mesh the models. Two loads were applied: an oblique force (300 N and a vertical force (150 N. Analysis was performed to evaluate stress distributions and deformed contact separation at the peri-implant region. Results. The lowest von Mises stress levels were numerically observed for the Plug design. The lowest levels of contact separation were measured in the Fins model followed by the Bulbs design. Conclusions. Within the limitations of the applied methodology, adding targeted press-fit geometry to the RAI standard design will have a positive effect on stress distribution, lower concentration of bone stress, and will provide a better primary stability for this patient specific case.

  3. Design Context Aware Activity Recommender System for Iranian Customer Mind Activism in Online Shopping

    Directory of Open Access Journals (Sweden)

    Saber Pahlavan

    2013-11-01

    Full Text Available E-commerce has made life simple and innovative of individuals and groups. Nowadays, social networks are widely used by everyone. So, it is necessary to do appropriate and situation aware activities in these networks to gain benefits, In this research, a context aware recommender system has modeled for using in social networks focus on Iranian customer mind activism in online shopping. This system makes its recommendations for user based on behavior and activities of her friends in the same situation in social network. In other word, this modeled recommender system uses collaborative filtering algorithm. All the connections of user in social network, containing direct and indirect, are considered for recommending by recommender system; but, based on connection type and its distance to user, proportional factor is assigned. On the other, In this research we study the consumer behavior in online shopping of electronics especially in Iran. Primary data was collected through the questionnaire survey and by emails from personal contacts in two major cities of Iran. Price, time saving and convenience were identified as important factors which lead to certain buying behavior in online shopping.

  4. Custom-tailored adsorbers: A molecular dynamics study on optimal design of ion exchange chromatography material.

    Science.gov (United States)

    Lang, Katharina M H; Kittelmann, Jörg; Pilgram, Florian; Osberghaus, Anna; Hubbuch, Jürgen

    2015-09-25

    The performance of functionalized materials, e.g., ion exchange resins, depends on multiple resin characteristics, such as type of ligand, ligand density, the pore accessibility for a molecule, and backbone characteristics. Therefore, the screening and identification process for optimal resin characteristics for separation is very time and material consuming. Previous studies on the influence of resin characteristics have focused on an experimental approach and to a lesser extent on the mechanistic understanding of the adsorption mechanism. In this in silico study, a previously developed molecular dynamics (MD) tool is used, which simulates any given biomolecule on resins with varying ligand densities. We describe a set of simulations and experiments with four proteins and six resins varying in ligand density, and show that simulations and experiments correlate well in a wide range of ligand density. With this new approach simulations can be used as pre-experimental screening for optimal adsorber characteristics, reducing the actual number of screening experiments, which results in a faster and more knowledge-based development of custom-tailored adsorbers.

  5. Comparison of Occlusive and Open Application in a Psoriasis Plaque Test Design, Exemplarily Using Investigations of Mapracorat 0.1% Ointment versus Vehicle and Reference Drugs.

    Science.gov (United States)

    Wigger-Alberti, Walter; Williams, Ragna; von Mackensen, Yi-Ling; Hoffman-Wecker, Maciej; Grossmann, Ulrike; Staedtler, Gerald; Nkulikiyinka, Richard; Shakery, Kaweh

    2017-01-01

    Psoriasis plaque tests (PPTs) are important tools in the early phases of antipsoriatic drug development. Two distinct PPT design variants (open vs. occluded drug application) are commonly used, but no previous work has aimed to directly compare and contrast their performance. We compared the antipsoriatic efficacy of mapracorat 0.1% ointment and reference drugs reported in 2 separate studies, representing open and occluded PPT designs. The drug effect size was measured by sonography (mean change in echo-poor band thickness), chromametry, and standardized clinical assessment. Antipsoriatic effects were detectable for the study drugs in both occluded and open PPTs. Differences between the potency of antipsoriatic drugs and vehicle were observable. The total antipsoriatic effect size appeared to be higher in the occluded PPT than the open PPT, despite the shorter treatment duration (2 vs. 4 weeks). Effect dynamics over time revealed greater differences between some study drugs in the open PPT compared to the occluded PPT. Taking the higher technical challenges for the open PPT into account, we recommend the occluded PPT as a standard screening setting in early drug development. In special cases, considering certain drug aspects or study objectives that would require procedural adaptations, an open PPT could be the better-suited design. Finally, both PPT models show clear advantages: classification as phase I studies, small number of psoriatic subjects, relatively short study duration, excellent discrimination between compounds and concentrations, parallel measurement of treatment response, and go/no go decisions very early in clinical development. © 2017 S. Karger AG, Basel.

  6. Customer experience

    OpenAIRE

    Koperdáková, Zuzana

    2016-01-01

    Bachelor thesis deals with the theme of customer experience and terms related to this topic. The thesis consists of three parts. The first part explains the terms generally, as the experience or customer loyalty. The second part is dedicated to medotology used for Customer Experience Management. In the third part is described application of Customer Experience Management in practice, particularly in the context Touch Point Analyses in GE Money Bank.

  7. Formal computer-aided product family architecture design for mass customization

    DEFF Research Database (Denmark)

    Bonev, Martin; Hvam, Lars; Clarkson, John

    2015-01-01

    are informal, providing limited support for domain experts to communicate, synthesize and document architectures effectively. In single product design explicit visual models such as design structure matrices and node-link diagrams have been used in combination with structural analysis methods to overcome...

  8. Customized sequential designs for random simulation experiments: Kriging metamodeling and bootstrapping

    NARCIS (Netherlands)

    Beers, van W.C.M.; Kleijnen, J.P.C.

    2005-01-01

    This paper proposes a novel method to select an experimental design for interpolation in random simulation, especially discrete event simulation. (Though the paper focuses on Kriging, this design approach may also apply to other types of metamodels such as linear regression models.) Assuming that

  9. Corneal mucus plaques.

    Science.gov (United States)

    Fraunfelder, F T; Wright, P; Tripathi, R C

    1977-02-01

    Corneal mucus plaques adhered to the anterior corneal surface in 17 of 67 advanced cases of keratoconjunctivitis sicca. The plaques were translucent to opaque and varied in size and shape, from multiple isolated islands to bizarre patterns involving more than half the corneal surface. Ultrastructurally, they consisted of mucus mixed with desquamated degenerating epithelial cells and proteinaceous and lipoidal material. The condition may be symptomatic but can be controlled and prevented in most cases by topical ocular application of 10% acetylcysteine.

  10. Innovative approach for the in vitro research on biomedical scaffolds designed and customized with CAD-CAM technology.

    Science.gov (United States)

    Marrelli, Massimo; Pujia, Antonella; Palmieri, Francesca; Gatto, Roberto; Falisi, Giovanni; Gargari, Marco; Caruso, Silvia; Apicella, Davide; Rastelli, Claudio; Nardi, Gianna Maria; Paduano, Francesco; Tatullo, Marco

    2016-12-01

    Studies on biomaterials involve assays aimed to assess the interactions between the biomaterial and the cells seeded on its surface. However, the morphology of biomaterials is heterogeneous and it could be tricky to standardize the results among different biomaterials and the classic plastic plates. In this light, we decided to create, by means of computer-aided design (CAD) technology, a standardized sample model, with equal shape and sizes, able to fit into a classic shape of a 96-wells tissue culture plate (TCP). The design of this sample consists of a hole in the top in order to allow the injected cells to settle without them being able to slip from the sides of the sample to the bottom of the TCP wells. This CAD project is made using the software Pro-Engineer. The sample will totally fill the wells of the 96-well TCP. Dental pulp stem cells have been used to assess the ability of the different sample to support and promote the cell proliferation. Twelve titanium, 12 gold-palladium, and 12 zirconium oxide customized samples were designed by means of the software cam powermill, by importing the .stl file created in Pro-Engineer software. The proliferation rate of the tested scaffolds showed to be similar to the control in the group with the customized shape. We think that our method can be useful to test different types of scaffolds when a greater accuracy of the measurements is desirable in order to verify the cell behavior of these scaffolds. Our innovative method can improve the standardization process in the evaluation of cell behavior on different biomaterials to open the way to more reliable tests on biomatrices functionalized with drugs or growth factors applied to the future regenerative medicine. © The Author(s) 2016.

  11. Product Customization

    DEFF Research Database (Denmark)

    Hvam, Lars; Mortensen, Niels Henrik; Riis, Jesper

    For the majority of industrial companies, customizing products and services is among the most critical means to deliver true customer value and achieve superior competitive advantage. The challenge is not to customize products and services in itself – but to do it in a profitable way...... from more than 40 product configuration projects in companies providing customer tailored products and services........ The implementation of a product configuration system is among the most powerful ways of achieving this in practice, offering a reduction of the lead time for products and quotations, faster and more qualified responses to customer inquiries, fewer transfers of responsibility and fewer specification mistakes...

  12. Sweat equity: a team approach to designing a new technology:customer-driven design of a picture archiving and communications systems (PACS) that works

    Science.gov (United States)

    Gelish, Anthony; Wright, Linda C.

    1994-05-01

    This paper defines the roles of customers and suppliers, customer variables, and customer contributions to the system creation process, discusses expected outcomes for a customer- driven system development process, and illustrates how this approach was used in the development of digital radiology.

  13. Delineation of atherosclerotic plaque using subharmonic imaging filtering techniques and a commercial intravascular ultrasound system.

    Science.gov (United States)

    Sridharan, Anush; Eisenbrey, John R; Machado, Priscilla; deMuinck, Ebo D; Doyley, Marvin M; Forsberg, Flemming

    2013-01-01

    The ability to delineate atherosclerotic plaque from the surrounding tissue using custom-developed subharmonic imaging (SHI) digital filtering techniques was investigated in vivo using a commercially available system. Atherosclerosis was induced in the aorta of two Watanabe Heritable Hyperlipidemic rabbits following which injections of an ultrasound contrast agent (UCA) Definity (Lantheus Medical Imaging, N Billerica, Massachusetts) were administered. Imaging was performed using a Galaxy intravascular ultrasound (IVUS) scanner (Boston Scientific, Natick, Massachusetts) equipped with an Atlantis® SR Pro Imaging Catheter (Boston Scientific). Four preliminary band-pass filters were designed to isolate the subharmonic signal (from surrounding tissue) and applied to the radio-frequency (RF) data. Preliminary filter performances were compared in terms of vessel-tissue contrast-to-tissue ratio (CTR) and visual examination. Based on preliminary results, a subharmonic adaptive filter and a stopband (SB) filter were designed and applied to the RF data. Images were classified as fundamental, SHI, and SB. Four readers performed qualitative analysis of 168 randomly selected images (across all three imaging modes). The images were scored for overall image quality, image noise, plaque visualization, and vessel lumen visualization. A Wilcoxon signed-rank test was used to compare the scores followed by intraclass correlation (ICC) evaluation. Quantitative analysis was performed by calculating the CTRs for the vessel-to-plaque and vessel-to-tissue (compared using a paired student's t test). Qualitative analysis showed SHI and SB to have significantly less image noise relative to the fundamental mode (p < 0.001). Fundamental mode scored significantly higher than SHI and SB for the remaining three categories. ICC showed mixed results among reader evaluation for delineation of plaque. However, quantitatively, SHI produced the best vessel-plaque CTR.

  14. Computer assisted reconstruction of three-dimensional canal model of femur and design for custom-made stem

    Institute of Scientific and Technical Information of China (English)

    刘建国; 李冬松; 马卫华; 周振平; 徐莘香

    2004-01-01

    @@ The maximum stem-cortical bone contact plays a dominant role in the long-term fixation of the prosthesis; narrowing stem-cortical bone space and the bony ingrowths reduces the reaction to debris due to wear, the particle flows caused by the wear debris, the bone resorption, and the growth of pseudomembrane.1-4 We realized that the endosteal contour varies significantly from person to person.5,6 Thus, only one common designed prosthesis is not sufficient to achieve a high degree of accuracy in terms of modelling the proximal femur, therefore computer-assisted reconstruction of a three-dimensional canal model of the femur is a very promising way to produce custom hip stem prostheses.7-9

  15. Custom-designed orthopedic implants evaluated using finite element analysis of patient-specific computed tomography data: femoral-component case study

    Directory of Open Access Journals (Sweden)

    Nayfeh Jamal F

    2007-09-01

    Full Text Available Abstract Background Conventional knee and hip implant systems have been in use for many years with good success. However, the custom design of implant components based on patient-specific anatomy has been attempted to overcome existing shortcomings of current designs. The longevity of cementless implant components is highly dependent on the initial fit between the bone surface and the implant. The bone-implant interface design has historically been limited by the surgical tools and cutting guides available; and the cost of fabricating custom-designed implant components has been prohibitive. Methods This paper describes an approach where the custom design is based on a Computed Tomography scan of the patient's joint. The proposed design will customize both the articulating surface and the bone-implant interface to address the most common problems found with conventional knee-implant components. Finite Element Analysis is used to evaluate and compare the proposed design of a custom femoral component with a conventional design. Results The proposed design shows a more even stress distribution on the bone-implant interface surface, which will reduce the uneven bone remodeling that can lead to premature loosening. Conclusion The proposed custom femoral component design has the following advantages compared with a conventional femoral component. (i Since the articulating surface closely mimics the shape of the distal femur, there is no need for resurfacing of the patella or gait change. (ii Owing to the resulting stress distribution, bone remodeling is even and the risk of premature loosening might be reduced. (iii Because the bone-implant interface can accommodate anatomical abnormalities at the distal femur, the need for surgical interventions and fitting of filler components is reduced. (iv Given that the bone-implant interface is customized, about 40% less bone must be removed. The primary disadvantages are the time and cost required for the

  16. Knowledge-based synthesis of custom VLSI physical design tools: First steps

    Science.gov (United States)

    Setliff, Dorothy E.; Rutenbar, Rob A.

    A description is given of how program synthesis techniques can be applied to the synthesis of technology-sensitive VLSI physical design tools. Physical design refers to the process of reducing a structural description of a piece of hardware down to the geometric layout of an integrated circuit. Successful physical design tools must cope with shifting technology and application environments. The goal is to automatically generate a tool's implementation to match the application. The authors describe a synthesis architecture that combines knowledge of the application domain and knowledge of generic programming mechanics. The approach uses a very high-level language to describe algorithms, domain and programming knowledge to select appropriate algorithms and data structures, and code generation to arrive at final executable code. Results are presented detailing the performance and implementation of ELF, a prototype generator for wire-routing applications. Comparisons between a hand-crafted router and an automatically synthesized router are presented.

  17. Real-time mobile customer short message system design and implementation

    Science.gov (United States)

    Han, Qirui; Sun, Fang

    To expand the current mobile phone short message service, and to make the contact between schools, teachers, parents and feedback of the modern school office system more timely and conveniently, designed and developed the Short Message System based on the Linux platform. The state-of-the-art principles and designed proposals in the Short Message System based on the Linux platform are introduced. Finally we propose an optimized secure access authentication method. At present, many schools,vbusinesses and research institutions ratify the promotion and application the messaging system gradually, which has shown benign market prospects.

  18. Teaching-Material Design Center: An Ontology-Based System for Customizing Reusable e-Materials

    Science.gov (United States)

    Wang, Hei-Chia; Hsu, Chien-Wei

    2006-01-01

    Use of electronic teaching materials (e-material) to support teaching is a trend. e-Material design is therefore an important issue. Currently, most e-material providers offer a package of solutions for different purposes. However, not all teachers and learners need everything from a single package. A preferable alternative is to find useful…

  19. Co-creating the future: Design practices and tools for effective customer co-creation

    NARCIS (Netherlands)

    Calabretta, G.; Gemser, G.; Karpen, I.

    2015-01-01

    In this paper, we integrate literature on service-dominant logic (SDL) and innovation to examine the role of designers and their practices for collaborative resource innovation. More specifically, in taking a co-creation perspective we uncover a portfolio of practices that facilitate resource integr

  20. Full Custom Design of a 8-bit Subranging Flash A/D Convertor

    Directory of Open Access Journals (Sweden)

    J. Sevenhans

    1993-07-01

    Full Text Available This paper describes the design of a Nonius Flash Analog to Digital Convertor for video-applications. The conversion is split up in two stages: the MSB and the LSB conversion stage. In the LSB conversion stage, the reference-voltage for the comparators is shifted up and down as a nonius of a vernier gauge, according to the MSB conversion obtained in the first half clock cycle. The MSB's and LSB's are simultaneously available at the output to make a 8-bit representation of the analog signal. Using the subranging mechanism, the number of comparators is reduced from 256 to 32 and the Nonius approach results in a very simple configuration for the subranging switches. The design has been simulated with HSPICE in ES2 1. 5 CMOS technology.

  1. Efficient Targeted Mutagenesis in Medaka Using Custom-Designed Transcription Activator-Like Effector Nucleases

    OpenAIRE

    Ansai, Satoshi; Sakuma, Tetsushi; Yamamoto, Takashi; Ariga, Hiroyoshi; Uemura, Norihito; Takahashi, Ryosuke; Kinoshita, Masato

    2013-01-01

    Transcription activator-like effector nucleases (TALENs) have become powerful tools for targeted genome editing. Here we demonstrate efficient targeted mutagenesis in medaka (Oryzias latipes), which serves as an excellent vertebrate model for genetics and genomics. We designed and constructed a pair of TALENs targeting the medaka DJ-1 gene, a homolog of human DJ-1 (PARK7). These TALENs induced a number of insertions and deletions in the injected embryos with extremely high efficiency. This in...

  2. Public transport service design requirements for the changing face of the South African customer

    CSIR Research Space (South Africa)

    Mokonyama, Mathetha T

    2008-04-01

    Full Text Available purpose On a typical day in South Africa, education trips remain the predominant trip purpose followed by shopping, visiting and work (Table 1). However, the public transport system has historically been designed to cater for the work-based commuter..., such as private travel surcharges, given their characteristically high demand elasticities. Table 1. Trip purpose on a normal day in South Africa (Source: Department of Transport, 2003) Trip purpose Male Female Total number of trips reported Education 51% 49...

  3. Customized schematic eye model for refraction correction design based on ocular wavefront and corneal topography measurements

    Science.gov (United States)

    Curatu, Eugene O.; Pettit, George H.; Campin, John A.

    2002-06-01

    The subject of this paper relates to the ocular optical design and vision analysis of refractive correction of the eye. After the purpose statement and the assumption list, the concept of the schematic eye matching a particular (measured) wavefront is introduced. This concept is based on the fact that the ocular wavefront, together with the corneal topography, can be seen as the mathematical global representation of the eye working in monochromatic light and having a foveal vision. The discussed design technique, including an iterative optimization method, could be applied in any ocular correction that utilizes cornea topography and/or ocular wavefront, e.g. contact lens or intra-corneal implant. However, the application this paper refers to is the ocular refractive correction by a procedure using the LADARVISION. It consists of surgical removal and subsequent replacement of a corneal flap on a stromal surface whose shape has been changed by laser ablation of the tissue. Subsequent sections of this paper are dedicated to establishing the limits of possible refractive correction, the influences of the flap and corneal topography into the refractive correction calculation. Finally a realistic evaluation of the results and a list of possible developments of this new optical design method are discussed.

  4. 一种客户满意度调查系统设计方案%A Design of Customer Satisfaction Survey System

    Institute of Scientific and Technical Information of China (English)

    朱晔

    2012-01-01

    Customer Satisfaction Research (CSR) is a measure in the degree of the achievement a business or an enterprise get in meeting or exceeding the expectations of customers when they pay for the products or the service. The process of measuring the satisfaction of customers is called Customer Satisfaction Research. This paper mainly talks about the definition of the function of the customer satisfaction survey system, as well as the analysis to the module design, then, it goes into the data structure, interface and the security design of the system. At last, it illustrates the detailed steps to make the program come true, by representing the functions and cases of design of every module.%顾客满意度调查(CSR)是用来测量一家企业或一个行业在满足或超过顾客购买产品的期望方面所达到的程度,测量顾客满意度的过程就是顾客满意度调查。本文对满意度调查系统功能的定义和模块设计分析,数据结构以及系统接口和安全性能的设计;最好给出了具体的系统实现步骤,并定义了系统各个模块的功能以及设计。

  5. Design of a real-time wind turbine simulator using a custom parallel architecture

    Science.gov (United States)

    Hoffman, John A.; Gluck, R.; Sridhar, S.

    1995-01-01

    The design of a new parallel-processing digital simulator is described. The new simulator has been developed specifically for analysis of wind energy systems in real time. The new processor has been named: the Wind Energy System Time-domain simulator, version 3 (WEST-3). Like previous WEST versions, WEST-3 performs many computations in parallel. The modules in WEST-3 are pure digital processors, however. These digital processors can be programmed individually and operated in concert to achieve real-time simulation of wind turbine systems. Because of this programmability, WEST-3 is very much more flexible and general than its two predecessors. The design features of WEST-3 are described to show how the system produces high-speed solutions of nonlinear time-domain equations. WEST-3 has two very fast Computational Units (CU's) that use minicomputer technology plus special architectural features that make them many times faster than a microcomputer. These CU's are needed to perform the complex computations associated with the wind turbine rotor system in real time. The parallel architecture of the CU causes several tasks to be done in each cycle, including an IO operation and the combination of a multiply, add, and store. The WEST-3 simulator can be expanded at any time for additional computational power. This is possible because the CU's interfaced to each other and to other portions of the simulation using special serial buses. These buses can be 'patched' together in essentially any configuration (in a manner very similar to the programming methods used in analog computation) to balance the input/ output requirements. CU's can be added in any number to share a given computational load. This flexible bus feature is very different from many other parallel processors which usually have a throughput limit because of rigid bus architecture.

  6. Why people continue to play online games: in search of critical design factors to increase customer loyalty to online contents.

    Science.gov (United States)

    Choi, Dongseong; Kim, Jinwoo

    2004-02-01

    As people increasingly play online games, numerous new features have been proposed to increase players' log-on time at online gaming sites. However, few studies have investigated why people continue to play certain online games or which design features are most closely related to the amount of time spent by players at particular online gaming sites. This study proposes a theoretical model using the concepts of customer loyalty, flow, personal interaction, and social interaction to explain why people continue to play online network games. The study then conducts a large-scale survey to validate the model. Finally, it analyzes current online games to identify design features that are closely related to the theoretical concepts. The results indicate that people continue to play online games if they have optimal experiences while playing the games. This optimal experience can be attained if the player has effective personal interaction with the system or pleasant social interactions with other people connected to the Internet. Personal interaction can be facilitated by providing appropriate goals, operators and feedback; social interaction can be facilitated through appropriate communication places and tools. This paper ends with the implications of applying the study results to other domains such as e-commerce and cyber communities.

  7. A new nanocomposite forward osmosis membrane custom-designed for treating shale gas wastewater

    Science.gov (United States)

    Qin, Detao; Liu, Zhaoyang; Delai Sun, Darren; Song, Xiaoxiao; Bai, Hongwei

    2015-09-01

    Managing the wastewater discharged from oil and shale gas fields is a big challenge, because this kind of wastewater is normally polluted by high contents of both oils and salts. Conventional pressure-driven membranes experience little success for treating this wastewater because of either severe membrane fouling or incapability of desalination. In this study, we designed a new nanocomposite forward osmosis (FO) membrane for accomplishing simultaneous oil/water separation and desalination. This nanocomposite FO membrane is composed of an oil-repelling and salt-rejecting hydrogel selective layer on top of a graphene oxide (GO) nanosheets infused polymeric support layer. The hydrogel selective layer demonstrates strong underwater oleophobicity that leads to superior anti-fouling capability under various oil/water emulsions, and the infused GO in support layer can significantly mitigate internal concentration polarization (ICP) through reducing FO membrane structural parameter by as much as 20%. Compared with commercial FO membrane, this new FO membrane demonstrates more than three times higher water flux, higher removals for oil and salts (>99.9% for oil and >99.7% for multivalent ions) and significantly lower fouling tendency when investigated with simulated shale gas wastewater. These combined merits will endorse this new FO membrane with wide applications in treating highly saline and oily wastewaters.

  8. Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases.

    Science.gov (United States)

    Ansai, Satoshi; Sakuma, Tetsushi; Yamamoto, Takashi; Ariga, Hiroyoshi; Uemura, Norihito; Takahashi, Ryosuke; Kinoshita, Masato

    2013-03-01

    Transcription activator-like effector nucleases (TALENs) have become powerful tools for targeted genome editing. Here we demonstrate efficient targeted mutagenesis in medaka (Oryzias latipes), which serves as an excellent vertebrate model for genetics and genomics. We designed and constructed a pair of TALENs targeting the medaka DJ-1 gene, a homolog of human DJ-1 (PARK7). These TALENs induced a number of insertions and deletions in the injected embryos with extremely high efficiency. This induction of mutations occurred in a dose-dependent manner. All screened G0 fish injected with the TALENs transmitted the TALEN-induced mutations to the next generation with high efficiency (44-100%). We also confirmed that these TALENs induced site-specific mutations because none of the mutations were found at potential off-target sites. In addition, the DJ-1 protein was lost in DJ-1(Δ7/Δ7) fish that carried a TALEN-induced frameshift mutation in both alleles. We also investigated the effect of the N- and C-terminal regions of the transcription activator-like (TAL) effector domain on the gene-disrupting activity of DJ1-TALENs and found that 287 amino acids at the N terminus and 63 amino acids at the C terminus of the TAL domain exhibited the highest disrupting activity in the injected embryos. Our results suggest that TALENs enable us to rapidly and efficiently establish knockout medaka strains. This is the first report of targeted mutagenesis in medaka using TALENs. The TALEN technology will expand the potential of medaka as a model system for genetics and genomics.

  9. 大规模定制模式下的产品设计技术%Technology for Product Design under Mass Customization

    Institute of Scientific and Technical Information of China (English)

    冯涓

    2000-01-01

    With the development of global market, the competition focus is on how to meet the various demands of various customers. Mass Customization is a new model for manufacture and design, whose aim is to combine the advantages of Mass Production and Customization so as to meet the individual customer's need uniquely, while without losing the enterprises' economic benefits.This paper discusses the thought and technology of product design under Mass Customization.%随着全球化市场的形成,企业的竞争焦点已经集中于如何更好地满足消费者多样化的需求。大规模定制是一种崭新的生产和设计模式,它力图将大规模生产与定制生产这两种模式的优势结合起来,在无损于企业经济效益的前提下,了解并满足单个用户的特殊需求。本文着重探讨大规模定制模式下的产品设计的理念和技术。

  10. Designing and validating a customized virtual reality-based laparoscopic skills curriculum.

    Science.gov (United States)

    Panait, Lucian; Bell, Robert L; Roberts, Kurt E; Duffy, Andrew J

    2008-01-01

    We developed and instituted a laparoscopic skills curriculum based on a virtual reality simulator, LapSim (Surgical Science, Göteborg, Sweden). Our goal was to improve basic skills in our residents. The hypothesis of this study is that performance in our course will differentiate levels of experience in the training program, establishing construct validity for our curriculum. We designed a novel curriculum that consisted of 17 practice modules and a 7-part examination. All residents who completed the curriculum successfully were included in this study. Performance to complete the examination was analyzed. Data were stratified by level of training. University surgical skill training laboratory. In all, 29 residents of all levels of training and 3 attending surgeons completed the curriculum. The average number of practice repetitions required was 243. To complete the examination component, junior residents (R1-R3) required more repetitions than senior residents (R4, R5), 28.3 versus 13.9, respectively (p < 0.002). Tasks on camera and instrument navigation as well as coordination did not reveal significant differences. The complex grasping task demonstrated significant differences in repetitions required for each level of training: 19.5 attempts for R1, 17.2 for R2, 13 for R3, 8.5 for R4, and 3 for R5 (p < 0.04). The 2 cutting drills, which required precise use of the left hand, required 7.9 repetitions for junior residents versus 2.7 for senior residents (p < 0.009). A clip application drill differentiated among junior residents with 39.4, 19.8, and 8.5 repetitions required for R1, R2, and R3, respectively (p < 0.05). Senior residents performed equivalent to attendings on this drill. A lifting and grasping drill differentiates among junior residents, senior residents, and attendings (p < 0.03). Individual performance in our curriculum correlates with the level of training for many drills, which establishes construct validity for this curriculum. Noncontributory

  11. Plaque Type Blue Naevus

    Directory of Open Access Journals (Sweden)

    Sentamilselvi G

    1997-01-01

    Full Text Available A case of plaque type blue naevus was encountered in a Dermatology Clinic in Madras. The various clinical differential diagnoses are discussed, the hitopathological features described and the benign nature of the tumour stressed. The case is reported for its rarity and to create an awareness of this entity.

  12. A novel approach for computer-assisted template-guided autotransplantation of teeth with custom 3d designed/printed surgical tooling. An ex vivo proof of concept

    NARCIS (Netherlands)

    Anssari Moin, D.; Derksen, W.; Verweij, J.P.; van Merkesteyn, R.; Wismeijer, D.

    2016-01-01

    Purpose: The aim of this study was to introduce a novel method for accurate autotransplantation with computer-assisted guided templates and assembled custom-designed surgical tooling and to test the feasibility and accuracy of this method ex vivo. Materials and Methods: A partially edentulous human

  13. Preliminary Study of the Overall Customized Furniture Product Design%整体定制家具产品设计初探

    Institute of Scientific and Technical Information of China (English)

    汪杉; 彭娟

    2016-01-01

    With the continuous improvement of people's living standard, People's aesthetic sense as well as the requirements of the home environment gradually tend to personalized and high quality, overall custom furniture is becoming more and more popular in this background. This paper mainly introduces some species of the overall customized furniture and some kinds of whole custom furniture design present situation of survival, Describes the design process in the actual production of the whole custom furniture of some of the basic design requirements and constraints in the design process. In order to satisfy the requirements of individual, the whole custom furniture design should also be considered in detail in terms of economy, function, practicality and style.%随着人们生活水平的不断提高,人们的审美观念以及对家居环境的要求也逐渐趋于个性化和高质量化,整体定制家具产品设计也就是在这样的时代背景下应运而生。本文从整体定制家具的一些种类以及整体定制家具设计目前的生存状况入手,阐述了在实际生产设计过程中对整体定制家具的一些基本设计要求以及在设计过程中的制约因素。进行整体定制家具设计时在满足个性化要求的前提条件下还应当从经济性、功能性、实用性以及风格协调性等方面进行详细的考量。

  14. Cystatin C is Associated With Plaque Phenotype and Plaque Burden

    Directory of Open Access Journals (Sweden)

    Yufeng Wen

    2016-03-01

    Full Text Available Background/Aims: The relationship between carotid artery plaque burden, phenotype and serum cystatin C at normal and impaired renal function is still unclear. Methods: Demographic characteristics, carotid ultrasonography and other relevant information of 1,477 patients were collected. The association of carotid artery plaque burden, plaque phenotype with serum cystatin C was evaluated by strategy analysis based on renal function. Results: Serum cystatin C (OR=2.05, 95% CI: 1.83-2.29, POR=1.60, 95%CI: 1.43-1.78, POR=1.21, 95%CI: 1.10-1.32, P Conclusion: In normal renal function, serum cystatin C may confer stability of plaques. In mildly impaired renal function, serum cystatin C is a risk predictor of plaques. In normal renal function circumstances, serum cystatin C may benefit to the stability of plaques. In mild impaired renal function circumstances, serum cystatin C are a risk predictors of plaques.

  15. The plaque inhibitory effect of a CPC mouthrinse in a 3-day plaque accumulation model - a cross-over study

    NARCIS (Netherlands)

    Versteeg, P.A.; Rosema, N.A.M.; Hoenderdos, N.L.; Slot, D.E.; van der Weijden, G.A.

    2010-01-01

    Objective:  To test the plaque inhibitory effect of an experimental 0.07% cetylpyridinium chloride (CPC) mouthrinse in a 3-day plaque accumulation model in a cross-over design. Material and Methods:  A total of 30 subjects (non-dental students), ≥18 years of age, were randomly assigned to use one of

  16. Bank Customers Management System

    Directory of Open Access Journals (Sweden)

    Ebubeogu Amarachukwu Felix

    2015-08-01

    Full Text Available ABSTRACT The purpose of this project is in partial fulfilment of the requirements of Bachelor of Science Hon in Information Technology. The Design and development of this Bank customers Management system provides a more secured approach in managing bank customers information which strengthens the relationships between banks and their customers by providing the right solutions that uses a multi-level security to improve customer satisfaction. The technology used in developing this project is ASP.NET and the programming language used to develop this project is C and the IDE used is Microsoft Visual Studio 2013 professional in designing the front end while the back end uses Microsoft SQL Server 2012.

  17. Custom fractional factorial designs to develop atorvastatin self-nanoemulsifying and nanosuspension delivery systems – enhancement of oral bioavailability

    Directory of Open Access Journals (Sweden)

    Hashem FM

    2015-06-01

    Full Text Available Fahima M Hashem,1 Majid M Al-Sawahli,2 Mohamed Nasr,1 Osama AA Ahmed3,4 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, Egypt; 2Holding Company for Biological Products and Vaccines (VACSERA, Giza, Egypt; 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 4Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Minia University, Minia, Egypt Abstract: Poor water solubility of a drug is a major challenge in drug delivery research and a main cause for limited bioavailability and pharmacokinetic parameters. This work aims to utilize custom fractional factorial design to assess the development of self-nanoemulsifying drug delivery systems (SNEDDS and solid nanosuspensions (NS in order to enhance the oral delivery of atorvastatin (ATR. According to the design, 14 experimental runs of ATR SNEDDS were formulated utilizing the highly ATR solubilizing SNEDDS components: oleic acid, Tween 80, and propylene glycol. In addition, 12 runs of NS were formulated by the antisolvent precipitation–ultrasonication method. Optimized formulations of SNEDDS and solid NS, deduced from the design, were characterized. Optimized SNEDDS formula exhibited mean globule size of 73.5 nm, zeta potential magnitude of -24.1 mV, and 13.5 µs/cm of electrical conductivity. Optimized solid NS formula exhibited mean particle size of 260.3 nm, 7.4 mV of zeta potential, and 93.2% of yield percentage. Transmission electron microscopy showed SNEDDS droplets formula as discrete spheres. The solid NS morphology showed flaky nanoparticles with irregular shapes using scanning electron microscopy. The release behavior of the optimized SNEDDS formula showed 56.78% of cumulative ATR release after 10 minutes. Solid NS formula showed lower rate of release in the first 30 minutes. Bioavailability estimation in Wistar albino rats revealed an augmentation

  18. The emancipated energy customer - new possibilities for communication and in designing energy rate systems; Der muendige Energiekunde - neue Moeglichkeiten der Kommunikation und Tarifmodellgestaltung

    Energy Technology Data Exchange (ETDEWEB)

    Thiemann, R.; Passenberg, I.; Suer, S. [IBM Global Business Services, Duesseldorf (Germany)

    2008-01-15

    Whoever wants to attract new and bind existing customers must be familiar with their life habits, behaviours and needs. This rule applies for energy providers just much as it does for other types of enterprise. A study by the business consultancy IBM Global Business Services has illuminated consumers' everyday use of and perspectives on energy. It transpires that customer behaviour is characterised by contradictions. Whereas on one side price and environmental issues play a significant role, on the other so does their personal comfort. The results of the study show that these conflicting priorities open up new possibilities for energy providers to communicate with their customers and design their energy rate systems.

  19. Custom-Made Computer-Aided-Design/Computer-Aided-Manufacturing Biphasic Calcium-Phosphate Scaffold for Augmentation of an Atrophic Mandibular Anterior Ridge

    Directory of Open Access Journals (Sweden)

    Francesco Guido Mangano

    2015-01-01

    Full Text Available This report documents the clinical, radiographic, and histologic outcome of a custom-made computer-aided-design/computer-aided-manufactured (CAD/CAM scaffold used for the alveolar ridge augmentation of a severely atrophic anterior mandible. Computed tomographic (CT images of an atrophic anterior mandible were acquired and modified into a 3-dimensional (3D reconstruction model; this was transferred to a CAD program, where a custom-made scaffold was designed. CAM software generated a set of tool-paths for the manufacture of the scaffold on a computer-numerical-control milling machine into the exact shape of the 3D design. A custom-made scaffold was milled from a synthetic micromacroporous biphasic calcium phosphate (BCP block. The scaffold closely matched the shape of the defect: this helped to reduce the time for the surgery and contributed to good healing. One year later, newly formed and well-integrated bone was clinically available, and two implants (AnyRidge, MegaGen, Gyeongbuk, South Korea were placed. The histologic samples retrieved from the implant sites revealed compact mature bone undergoing remodelling, marrow spaces, and newly formed trabecular bone surrounded by residual BCP particles. This study demonstrates that custom-made scaffolds can be fabricated by combining CT scans and CAD/CAM techniques. Further studies on a larger sample of patients are needed to confirm these results.

  20. Impact of product development efforts on product introduction and product customization abilities:investigating the effects of product design complexity and product development order winners

    OpenAIRE

    Chaudhuri, Atanu; Dawar, Saloni

    2014-01-01

    This paper investigates the impact of efforts in new product development-manufacturing integration (NPDMI) on new product introduction (NPI) and product customization (PC) abilities and the moderating effects of product design complexity and importance of new product development order winners (NPIOW) on the above relationships. The results from the data on 136 Indian manufacturing plants show that NPDMI, product design complexity and NPIOW all have significant positive impact on NPI and PC ab...

  1. Customer Integration during Innovation Development

    DEFF Research Database (Denmark)

    Pedrosa, Alex

    2012-01-01

    To stay viable, companies need to increase their innovation development investments over time. However, successful innovation development also cannot happen without customers, and thus companies seek opportunities to enhance their knowledge of current and future customer needs. As a result...... of companies’ growing interest in effectively collaborating with customers, research has investigated the importance of firm–customer interaction during innovation development. However, despite valuable insights into the performance-enhancing effects of customer integration, research has thus far overlooked...... the activities companies should engage in when integrating customers during innovation development. Thus, this study investigates how and when customer-oriented companies engage in customer interaction during innovation development. Using a multiple case study design, this study examines four substantive cases...

  2. Electricity Customers

    Science.gov (United States)

    This page discusses key sectors and how they use electricity. Residential, commercial, and industrial customers each account for roughly one-third of the nation’s electricity use. The transportation sector also accounts for a small fraction of electricity.

  3. Assesment of customer relationship development

    Directory of Open Access Journals (Sweden)

    Dagmar Lesáková

    2011-01-01

    Full Text Available The focus of this paper is customer relationship marketing and its new trends. The particular goal of the presented research study was to identify and analyse the indicators of customer relationship development in human resources recruitment / leasing companies. Nine indicators have been explored: mission statement concerning customer commitment, customer attraction, customer commitment, development of customer value, understanding customer needs, goals for customer satisfaction, after sales services, measurement of customer satisfaction, complaint management. The indicators were made sequentially operational in order to translate customer relationship development into specific activities designed to increase business performance. Based on a set of customer indicators four scientific hypotheses were tested. We proved that strong customer orientation has a positive impact on business performance. Out of nine indicators, seven of them have a strong impact on business outcomes. The research confirms that business performance increases with firm size and market density, and that introduction of quality management systems improves company performance. Finally, the appropriateness of the customer relationship indicators applied in human resources recruitment companies is discussed.

  4. Application of Custom Furniture Design in Interior Decoration%定制家具设计在室内装修中的应用

    Institute of Scientific and Technical Information of China (English)

    刘鹏刚; 孙浩

    2014-01-01

    定制家具作为室内装修的重要组成部分,存在着个性化和功能化之间的矛盾。通过对室内装修中的定制家具设计要素进行剖析和概括,对工艺和结构问题进行深入地探讨,发现了定制家具在设计和安装方面的特殊性问题及其形成原因,解决了定制家具设计既满足了消费者在室内装修中的个性化心理需求,又确保了合理使用功能,为定制家具在室内装修中的应用提供了设计、制造和安装的相关注意事项及其解决方法。%As an important part of interior decoration, there is a conflict between the individual and the functional in Custom furniture. To analyze and summarize the design elements of custom furniture for interior decoration, in-depth discussion on the question of process and structure, found the custom furniture special problems in the design and installation of and the reasons for its formation, the custom furniture design can satisfy the individuation of the psychological needs of consumers in the decoration, but also ensures the reasonable the use of function, for the application of custom furniture in interior decoration provides design, manufacture and installation of the relevant matters and their solutions.

  5. Customer satisfaction.

    Science.gov (United States)

    Vukmir, Rade B

    2006-01-01

    This paper seeks to present an analysis of the literature examining objective information concerning the subject of customer service, as it applies to the current medical practice. Hopefully, this information will be synthesized to generate a cogent approach to correlate customer service with quality. Articles were obtained by an English language search of MEDLINE from January 1976 to July 2005. This computerized search was supplemented with literature from the author's personal collection of peer-reviewed articles on customer service in a medical setting. This information was presented in a qualitative fashion. There is a significant lack of objective data correlating customer service objectives, patient satisfaction and quality of care. Patients present predominantly for the convenience of emergency department care. Specifics of satisfaction are directed to the timing, and amount of "caring". Demographic correlates including symptom presentation, practice style, location and physician issues directly impact on satisfaction. It is most helpful to develop a productive plan for the "difficult patient", emphasizing communication and empathy. Profiling of the customer satisfaction experience is best accomplished by examining the specifics of satisfaction, nature of the ED patient, demographic profile, symptom presentation and physician interventions emphasizing communication--especially with the difficult patient. The current emergency medicine customer service dilemmas are a complex interaction of both patient and physician factors specifically targeting both efficiency and patient satisfaction. Awareness of these issues particular to the emergency patient can help to maximize efficiency, minimize subsequent medicolegal risk and improve patient care if a tailored management plan is formulated.

  6. Designing Customer Agility Model Based on Organizational Dynamic Capabilities: Effect of IT Competence, Entrepreneurial Alertness and Market Acuity

    Directory of Open Access Journals (Sweden)

    Soheila Khoddami

    2012-01-01

    Full Text Available Today organizations face great environmental turbulence. High levels of environmental turbulence can paralyze a firm’s operations. Actually outputs of organization process in such environments depend on the firm’s ability to change management and its flexibility. Since one of the important changes in the turbulent environments is changing of needs and preferences of customers and also based on new marketing approach, in order to consider customer's needs, customer agility has been identified as the vital competency for the survival of organizations. Given the critical role of customer agility in turbulent competitive environment, this concept has attracted many researchers of management science in recent years. Therefore, it is vital for organizations to find how to achieve this important capability and it is important to note that very few researches have been done in this regard. Since one of the important tools for achieving customer agility in the organization is dynamic capabilities, therefore in this research the model of formation of customer agility in organization based on dynamic capabilities has been proposed and examined in electronics industry of Iran. The model includes IT competencies, entrepreneurial and market acuity for improving the output of organizational process. This model has been developed based on three management areas of strategic management literature related to dynamic capabilities and the literature of entrepreneurship and information technology. Findings of the sample approve the research model. In addition, it is concluded that dynamic capabilities of the organization will help shaping customer agility and customer agility has a positive effect on quality and efficiency of the process output.

  7. Hedging customers.

    Science.gov (United States)

    Dhar, Ravi; Glazer, Rashi

    2003-05-01

    You are a marketing director with $5 million to invest in customer acquisition and retention. Which customers do you acquire, and which do you retain? Up to a point, the choice is obvious: Keep the consistent big spenders and lose the erratic small ones. But what about the erratic big spenders and the consistent small ones? It's often unclear whether you should acquire or retain them and at what cost. Businesses have begun dealing with unpredictable customer behavior by following the practices of sophisticated investors who own portfolios comprising dozens of stocks with different, indeed divergent, histories and prospects. Each portfolio is diversified so as to produce the investor's desired returns at the particular level of uncertainty he or she can tolerate. Customers, too, are assets--risky assets. As with stocks, the cost of acquiring them is supposed to reflect the cash-flow values they are likely to generate. The authors explain how to construct a portfolio based on the notion that a customer's risk-adjusted lifetime value depends on its anticipated effect on the riskiness of the group it is joining. They also show how this approach was used to identify the best prospects for Myron Corporation, a global leader in the personalized business-gift industry. The concept of risk-adjusted lifetime value has a transforming power: For companies that rely on it, product managers will be replaced by customer managers, and the current method of accounting for profit and loss--which is by product--will be replaced by one that determines each customer's P&L. Once adjusted for risk, those P&Ls will become the firm's key performance and operational metric.

  8. La pelade par plaques

    Science.gov (United States)

    Spano, Frank; Donovan, Jeff C.

    2015-01-01

    Résumé Objectif Présenter aux médecins de famille des renseignements de base pour faire comprendre les schémas thérapeutiques et les résultats des traitements pour la pelade par plaques, de même que les aider à identifier les patients pour qui une demande de consultation en dermatologie pourrait s’imposer. Sources des données Une recension a été effectuée dans PubMed pour trouver des articles pertinents concernant le traitement de la pelade par plaques. Message principal La pelade par plaques est une forme auto-immune de perte pileuse qui touche à la fois les enfants et les adultes. Même s’il n’y a pas de mortalité associée à la maladie, la morbidité découlant des effets psychologiques de la perte des cheveux peut être dévastatrice. Lorsque la pelade par plaques et le sous-type de la maladie sont identifiés, un schéma thérapeutique approprié peut être amorcé pour aider à arrêter la chute des cheveux et possiblement faire commencer la repousse. Les traitements de première intention sont la triamcinolone intralésionnelle avec des corticostéroïdes topiques ou du minoxidil ou les 2. Les médecins de famille peuvent prescrire ces traitements en toute sécurité et amorcer ces thérapies. Les cas plus avancés ou réfractaires pourraient avoir besoin de diphénylcyclopropénone topique ou d’anthraline topique. On peut traiter la perte de cils avec des analogues de la prostaglandine. Les personnes ayant subi une perte de cheveux abondante peuvent recourir à des options de camouflage ou à des prothèses capillaires. Il est important de surveiller les troubles psychiatriques en raison des effets psychologiques profonds de la perte de cheveux. Conclusion Les médecins de famille verront de nombreux patients qui perdent leurs cheveux. La reconnaissance de la pelade par plaques et la compréhension du processus pathologique sous-jacent permettent d’amorcer un schéma thérapeutique approprié. Les cas plus graves ou r

  9. Customer Loyalty and Customer Relationship Management

    Science.gov (United States)

    Zhang, Pengwei; Li, Min; Jiao, Xiaojing; Zhou, Ruijin

    The contemporary company attaches great importance to marketing relationship and customer relations is the core of this relationship. Further, customer satisfaction and loyalty is the core of the customer relationship management. Sometimes, high customer satisfaction causes low profit because enterprises do not realize that strengthening the loyalty of the aimed customer is the key of customer relationship management.

  10. The customer has escaped.

    Science.gov (United States)

    Nunes, Paul F; Cespedes, Frank V

    2003-11-01

    Every company makes choices about the channels it will use to go to market. Traditionally, the decision to sell through a discount superstore or a pricey boutique, for instance, was guided by customer demographics. A company would identify a target segment of buyers and go with the channel that could deliver them. It was a fair assumption that certain customer types were held captive by certain channels--if not from cradle to grave, then at least from initial consideration to purchase. The problem, the authors say, is that today's customers have become unfettered. As their channel options have proliferated, they've come to recognize that different channels serve their needs better at different points in the buying process. The result is "value poaching." For example, certain channels hope to use higher margin sales to cover the cost of providing expensive high-touch services. Potential customers use these channels to do research, then leap to a cheaper channel when it's time to buy. Customers now hunt for bargains more aggressively; they've become more sophisticated about how companies market to them; and they are better equipped with information and technology to make advantageous decisions. What does this mean for your go-to-market strategy? The authors urge companies to make a fundamental shift in mind-set toward designing for buyer behaviors, not customer segments. A company should design pathways across channels to help its customers get what they need at each stage of the buying process--through one channel or another. Customers are not mindful of channel boundaries--and you shouldn't be either. Instead, they are mindful of the value of individual components in your channels--and you should be, too.

  11. Plaque removal efficacy of Colgate 360 toothbrush: A clinical study

    Science.gov (United States)

    Iyer, Nageshwar; Chandna, Shalu; Dhindsa, Abhishek; Damle, Dhanashree; Loomba, Ashish

    2016-01-01

    Aim: The aim of this clinical study was to confirm the plaque removal efficacy of the Colgate 360 Whole Mouth Clean Toothbrush. Study Design: This was a single-center, monadic, case–controlled study with the 7 days duration. Materials and Methods: A total of eighty participants (56 male and 24 female) aged between 18 and 45 years with a minimum of 20 permanent teeth (excluding the third molars) without any prosthetic crowns and an initial plaque score of minimum 1.5 as determined by Modified Quigley-Hein Plaque Index (1970) participated in the study. There were two dropouts during the study duration, one male and one female. The participants were instructed to brush for 1 min, after which plaque index was recorded again. They were then instructed to brush their teeth twice a day for 1 min with the assigned toothbrush (Colgate 360 Whole Mouth Clean Toothbrush) and a commercially available fluoride toothpaste for the next 7 days. On the 7th day, all the participants were recalled for follow-up and plaque examination. The plaque index scores (pre- and post-brushing) were recorded, tabulated, and analyzed statistically. Results: The mean plaque indices reduced after brushing both on day 1 and day 7. There was also a reduction in mean plaque indices from day 1 to day 7. All these reductions were statistically significant (P < 0.001). The reduction in plaque scores was independent of the gender of the participants however female participants showed lower scores as compared to male participants (P < 0.001). Conclusion: The present study demonstrated a significant reduction in plaque scores with the use of Colgate 360 Whole Mouth Clean Soft Toothbrush throughout the study period. Continued use resulted in a further significant reduction in plaque scores irrespective of the gender of participants. PMID:27630494

  12. Plaque removal efficacy of Colgate 360 toothbrush: A clinical study

    Directory of Open Access Journals (Sweden)

    Nageshwar Iyer

    2016-01-01

    Full Text Available Aim: The aim of this clinical study was to confirm the plaque removal efficacy of the Colgate 360 Whole Mouth Clean Toothbrush. Study Design: This was a single-center, monadic, case-controlled study with the 7 days duration. Materials and Methods: A total of eighty participants (56 male and 24 female aged between 18 and 45 years with a minimum of 20 permanent teeth (excluding the third molars without any prosthetic crowns and an initial plaque score of minimum 1.5 as determined by Modified Quigley-Hein Plaque Index (1970 participated in the study. There were two dropouts during the study duration, one male and one female. The participants were instructed to brush for 1 min, after which plaque index was recorded again. They were then instructed to brush their teeth twice a day for 1 min with the assigned toothbrush (Colgate 360 Whole Mouth Clean Toothbrush and a commercially available fluoride toothpaste for the next 7 days. On the 7 th day, all the participants were recalled for follow-up and plaque examination. The plaque index scores (pre- and post-brushing were recorded, tabulated, and analyzed statistically. Results: The mean plaque indices reduced after brushing both on day 1 and day 7. There was also a reduction in mean plaque indices from day 1 to day 7. All these reductions were statistically significant (P < 0.001. The reduction in plaque scores was independent of the gender of the participants however female participants showed lower scores as compared to male participants (P < 0.001. Conclusion: The present study demonstrated a significant reduction in plaque scores with the use of Colgate 360 Whole Mouth Clean Soft Toothbrush throughout the study period. Continued use resulted in a further significant reduction in plaque scores irrespective of the gender of participants.

  13. Customer portfolios

    DEFF Research Database (Denmark)

    Clarke, Ann Højbjerg; Freytag, Per Vagn; Zolkiewski, Judith

    2017-01-01

    gives managers a tool to help to cope with the dynamic aspects of the customer portfolio. Recognition of the importance of communication to the process, the development of trust and the role of legitimacy also provides areas that managers can focus upon in their relationship management processes......Purpose The purpose of this paper is to extend the discussion about customer portfolios beyond simple identification of models and how they can be used for balanced resource allocation to a discussion about how portfolios should take into account views from relationship partners and how they should...... that helps improve the understanding of how customer portfolio models can actually be applied from a relational perspective. Findings The key aspects of the conceptual framework relate to how alignment of the relationships in the portfolio is achieved. Critical to this are the interaction spaces...

  14. Customs Inspection

    Science.gov (United States)

    1977-05-01

    required, for the per- DASDD9-%M) ii the single point of contact for formance of customs inspection functions. customs inspecion matters .in the Office...STATUS Onfdlt dotl. member of Rr": 21 DATE if officer of corporation . slu title) ATP OoM 6A N-7s) PtavIoux MuITUONs MAY BE UN&D Figure l-9. Reld.. and...grips. Commonly called HW-4. Serial number over 300,000 denotes the in- corporation of modified hammer safety components. Model HW-5T Double Action

  15. Customer satisfaction

    DEFF Research Database (Denmark)

    Eskildsen, Jacob Kjær; Kristensen, Kai

    2007-01-01

    & Westlund, 2003) as well as the structure of the framework (Eskildsen et al., 2004). We know however very little about how the structure of the individual markets with respect to, for instance, how the transparency of products and services affects customer satisfaction. The aim of this article is to analyze...... the effect of the transparency of products and services on customer satisfaction with respect to Danish mobile phone companies, banks and supermarkets from 2004 based on the authors' experiences from the various analyses conducted within the EPSI rating initiative....

  16. The Customer Service Experience.

    Science.gov (United States)

    Bell, Chip R.

    2001-01-01

    Discusses ways to embed customer service learning and customer loyalty including making customers think, examining every aspect of customers' service encounters with staff, providing follow-up, making learning fun, and involving customers in your business. (JOW)

  17. The Customer Service Experience.

    Science.gov (United States)

    Bell, Chip R.

    2001-01-01

    Discusses ways to embed customer service learning and customer loyalty including making customers think, examining every aspect of customers' service encounters with staff, providing follow-up, making learning fun, and involving customers in your business. (JOW)

  18. Product customization

    DEFF Research Database (Denmark)

    Lueg, Rainer

    2015-01-01

    analysis and Activity-based Costing help managers to better understand the different profitability of customized product lines. The rather open questions at the end of the case study allow for an adjustment to the level of knowledge of the students. Students will need to reflect on how a mechanical...

  19. Study on product design support system for customer%面向客户的产品设计支持系统研究

    Institute of Scientific and Technical Information of China (English)

    潘柏松; 陈桂珍; 刘红

    2001-01-01

    Along with the growing of electronic commerce, more and more Customers hope to express more comprehensive product requirements ( Function, Time, Cost etc ) by Internet. The paper advances the development idea of product design support system for customer. Supported by design method based on function unit and product data management mechanism, the system faces customer requirements, and product rapid design is realized.%随着电子商务的发展,越来越多的客户希望在通过Internet网络发送订单的同时,表达更为全面的产品需求(功能、时间、成本等)。本文提出面向客户的产品设计支持系统的开发思想,系统在基于功能单元的设计思想和产品数据管理机制的支持下,面向客户需求,实现产品快速设计。

  20. Reviewing customer value literature: Comparing and contrasting customer values perspectives

    OpenAIRE

    Aija Paananen; Marko Seppänen

    2013-01-01

    Purpose: The paper provides a comprehensive and up-to-date literature review of customer value concepts and distinguishes complex customer value from the various perspectives. It structures the themes and dimensions between the various approaches along the customer value main lines in the literature. Design/methodology/approach: The paper reviews current literature and illustrates different types of value representations through a case example. Findings: Based on a comprehensive literature re...

  1. The design and achievement of customer resource management information system%客户资源管理信息系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    王本琪; 郑冰

    2012-01-01

    Along with the progress of modern technology and the company service scale unceasing expansion,enterprise customer increasing,the customer resource management information system only depends on traditional the manual way to be unable to satisfy enterprise the need to develop.In order to enhance the enterprise the service efficiency,decided uses the information method to process the enterprise the information,thereupon proposed the design has developed the customer information management system request,adapts the enterprise to develop.This design is for adapt,the customer information management system development which the enterprise needs to carry on uses the tool is ASP,supports the movement the environment is Microsoft Window98/2000/XP.The system can realize the customer basic information input,the revision,the inquiry,and can on time and the customer region carries on the statistics to the sales situation,but independently establishes the condition thus to achieve to sells the data the multi-angles inquiry function.In this paper,the system analysis,design and implementation process has been discussed in detail.%随着现代科技的进步,公司业务规模的不断扩大、企业客户的增多,客户资源管理信息系统单靠传统的手工方式已无法满足企业发展的需要。为提高企业的管理水平和办事效率,企业提出了实现管理信息化的要求,以适应企业发展的需要。针对企业的实际需求,采用基于WEB的B/S结构,以ASP作为开发工具,实现了客户资源基本信息的输入、修改、查询等功能,并能按时间和客户区域对销售情况进行统计;自主设定查询条件,实现对销售数据的多角度综合查询。本文主要对系统的分析、设计和实施过程进行了详细论述。

  2. Adalimumab: A Review in Chronic Plaque Psoriasis.

    Science.gov (United States)

    Burness, Celeste B; McKeage, Kate

    2015-12-01

    Adalimumab (Humira(®)) is a fully human monoclonal antibody against tumour necrosis factor (TNF), formulated for subcutaneous administration. It is well established in the treatment of adults with moderate-to-severe chronic plaque psoriasis and has recently received approval in the EU for the treatment of severe chronic plaque psoriasis in children and adolescents from 4 years of age. In a phase III trial in paediatric patients, a significantly greater proportion of patients receiving adalimumab 0.8 mg/kg (to a maximum of 40 mg) every other week (eow) achieved a ≥75 % improvement from baseline in Psoriasis Area and Severity Index than those receiving methotrexate after 16 weeks of treatment. In adults, well-designed randomized clinical trials demonstrated that adalimumab 40 mg eow effectively reduced the signs and symptoms of psoriasis and improved dermatology-specific and general measures of health-related quality of life, with these benefits sustained during long-term treatment. Adalimumab was generally well tolerated, compared with placebo or methotrexate, during clinical trials in paediatric and adult patients with chronic plaque psoriasis. Thus, adalimumab remains an important treatment strategy in adults with moderate-to-severe chronic plaque psoriasis and provides a promising new systemic treatment option for children and adolescents from 4 years of age with severe psoriasis.

  3. 嵌入式Linux下虚拟仪表界面定制设计%Customizing Design of Virtual Instrument GUI for Embedded Linux

    Institute of Scientific and Technical Information of China (English)

    王淑娟; 金敬强; 魏坤; 刘慧玲

    2013-01-01

    可视化程序设计以“所见及所得”的编程思想为原则,设计人员可以不用编写或只需编写很少的程序代码,即可完成图形用户界面的设计工作,这能够极大地提高设计人员的工作效率。基于以用户为中心的服务理念,为嵌入式Linux系统下以虚拟仪表显示为主的图形用户界面设计提供了界面定制功能,其流程包括定制界面显示、输入处理、代码生成和脚本执行4个步骤。界面定制功能降低了图形用户界面设计的门槛,为设计人员提供了更加友好的用户体验。%Programming visualization follows the principle of“what you see is what you get”,so that the designers could write much less or no code to finish the work of GUI design,which would apparently improve the efficiency of designers. Adhere to the idea of user oriented, we provide the interface customizing function for the designation of graphic user interface containing mainly virtual instruments for embedded Linux system. The procedure includes four steps: customizing interface display, input processing,code generation and script execution. The interface customizing function debases the doorsill of the GUI design and offers the designers much better experience.

  4. French Customs

    CERN Multimedia

    GS Department

    2010-01-01

    Please note that the French Customs (initially located in Building 904, Prévessin) are now located in Ferney-Voltaire (FR): Mrs Catherine NEUVILLE Douane de Ferney-Voltaire Rue de Genève F – 01210 Ferney-Voltaire Phone : 33 4 50 40 51 42 Email : catherine.neuville@douane.finances.gouv.fr Tom Wegelius Tel: 79947 Logistics and Site Services

  5. C-slow Technique vs Multiprocessor in designing Low Area Customized Instruction set Processor for Embedded Applications

    CERN Document Server

    Akram, Muhammad Adeel; Sarfaraz, Muhammad Masood

    2012-01-01

    The demand for high performance embedded processors, for consumer electronics, is rapidly increasing for the past few years. Many of these embedded processors depend upon custom built Instruction Ser Architecture (ISA) such as game processor (GPU), multimedia processors, DSP processors etc. Primary requirement for consumer electronic industry is low cost with high performance and low power consumption. A lot of research has been evolved to enhance the performance of embedded processors through parallel computing. But some of them focus superscalar processors i.e. single processors with more resources like Instruction Level Parallelism (ILP) which includes Very Long Instruction Word (VLIW) architecture, custom instruction set extensible processor architecture and others require more number of processing units on a single chip like Thread Level Parallelism (TLP) that includes Simultaneous Multithreading (SMT), Chip Multithreading (CMT) and Chip Multiprocessing (CMP). In this paper, we present a new technique, n...

  6. Self-Organizing Tool for Smart Design with Predictive Customer Needs and Wants to Realize Industry 4.0

    OpenAIRE

    Saldivar, Alfredo Alan Flores; Goh, Cindy SF; Chen, Wei-Neng; Li, Yun

    2016-01-01

    Following the first three industrial revolutions, Industry 4.0 (I4) aims at realizing mass customization at a mass production cost. Currently, however, there is a lack of smart analytics tools for achieving such a goal. This paper investigates this issues and then develops a predictive analytics framework integrating cloud computing, big data analysis, business informatics, communication technologies, and digital industrial production systems. Computational intelligence in the form of a self-...

  7. Maintaining Productivity of Rural Area in Indonesia: A Perspective of Total Customers Involvement from Design to Maintenance of a Local Wind Pump (LWP) Application

    Science.gov (United States)

    Yudiantoro, Beny; Taufik, Ahmad

    2007-10-01

    A sustainable study development on a local wind pump (LWP) has been indicated as one of solutions for maintaining stable productivity of marginal societies (traditional farmers, peasant and tribes) in facing multi crisis happened in Indonesia. Moreover, the study is designed to assess the LWP by accommodating a total participation of the societies as targeted customers. The participation was formulated from design to maintenance stages of the LWP. The approaches of implementation a QFD method, a field survey and life skill training have been fitted to the formulation. In this article, significant achievements resulted by the approaches are reported. The QFD was adopted to classify all of the parameters, constraints and boundaries which were obtained by questionnaire to the customers. All of the parameters were plotted in to a house of quality matrix (HOQ) which contributed to manufacture criteria and as well as maintenance criteria. The field study was accomplished in order to assess an availability value of the LWP components. The life skill training was conducted to equip manufacturing skill to the customers. Throughout the study, it was observed that the LWP was manufactured by accommodating 90% of a local materials and local components available in district markets of Lampung province Indonesia. Throughout the survey, critical parameters for a sustainable development of the LWP have been defined, namely government protection, capital investment for supplying component and maintenance networking for supporting the LWP performance. The life skill training given to the customers affected to incremental value of reliability in terms of maintenance skill. As a result, the LWP was indicated as a local competitive product of renewable energy (RE) to the society.

  8. Customization and Customer-Product Learning

    DEFF Research Database (Denmark)

    Jørgensen, Kaj Asbjørn

    2011-01-01

    , through the performance level and the experience level to the learning level at the top. This model has a dual view with customers/demand at one side and product/supplier at the other side. It is developed so that it can be generally applied and, typically, product designers must decide how far up...... in levels the customisation should aim. This paper sets special focus on the upper levels of customisation, especially the learning level, and it is shown that products with a large range of user-oriented functionalities often require much training to use and that customers on the other hand are sometimes......In order to support decision making in companies, who want to implement Mass Customisation (MC) and Product Configuration, a previously published model for customisation is developed. This model identifies customisation in four different levels, ranging from the structure level at the bottom...

  9. Mechanical model of vulnerable atherosclerotic plaque rupture

    Institute of Scientific and Technical Information of China (English)

    SU; Haijun; ZHANG; Mei; ZHANG; Yun

    2004-01-01

    Rupture of atherosclerotic plaque is the main trigger of acute cardiovascular events, but the mechanism of plaque rupture is still unknown. We have constructed a model describing the motion of the fibrous cap of the plaque using the theory of elastic mechanics and studied the stability of the plaque theoretically. It has shown that plaque rupture is the result of a dynamic interplay between factors intrinsic to the plaque itself and extrinsic factors. We have proposed a new mechanism of plaque rupture, given a new explanation about the nonlinear dynamic progress of atherosclerosis and suggested a method to identify the vulnerable plaques to manage atherosclerosis.

  10. Development of a software for the design of custom-made hip prostheses using an open-source rapid application development environment.

    Science.gov (United States)

    Viceconti, M; Testi, D; Gori, R; Zannoni, C

    2000-01-01

    The present work describes a technology transfer project called HIPCOM devoted to the re-engineering of the process used by a medical devices manufacturer to design custom-made hip prostheses. Although it started with insufficient support from the end-user management, a very tight scheduling and a moderate budget, the project developed into what is considered by all partners a success story. In particular, the development of the design software, called HIPCOM Interactive Design Environment (HIDE) was completed in a time shorter than any optimistic expectation. The software was quite stable since its first beta version, and once introduced at the user site it fully replaced the original procedure in less than two months. One year after the early adoption, more than 80 custom-made prostheses had been designed with HIDE and the user had reported only two bugs, both cosmetics. The scope of the present work was to report the development experience and to investigate the reasons for these positive results, with particular reference to the development procedure and the software architecture. The choice of TCL/TK as development language and the adoption of well-defined software architecture were found to be the success key factors. Other important determinants were found to be the adoption of an incremental software engineering strategy, well suited for small to medium projects and the presence in the development staff of a technology transfer expert.

  11. Multi-Dimensional Customer Data Analysis in Online Auctions

    Institute of Scientific and Technical Information of China (English)

    LAO Guoling; XIONG Kuan; QIN Zheng

    2007-01-01

    In this paper, we designed a customer-centered data warehouse system with five subjects: listing, bidding, transaction,accounts, and customer contact based on the business process of online auction companies. For each subject, we analyzed its fact indexes and dimensions. Then take transaction subject as example,analyzed the data warehouse model in detail, and got the multi-dimensional analysis structure of transaction subject. At last, using data mining to do customer segmentation, we divided customers into four types: impulse customer, prudent customer, potential customer, and ordinary customer. By the result of multi-dimensional customer data analysis, online auction companies can do more target marketing and increase customer loyalty.

  12. The four faces of mass customization.

    Science.gov (United States)

    Gilmore, J H; Pine, B J

    1997-01-01

    Virtually all executives today recognize the need to provide outstanding service to customers. Focusing on the customer, however, is both an imperative and a potential curse. In their desire to become customer driven, many companies have resorted to inventing new programs and procedures to meet every customer's request. But as customers and their needs grow increasingly diverse, such an approach has become a surefire way to add unnecessary cost and complexity to operations. Companies around the world have embraced mass customization in an attempt to avoid those pitfalls. Readily available information technology and flexible work processes permit them to customize goods or services for individual customers in high volumes at low cost. But many managers have discovered that mass customization itself can produce unnecessary cost and complexity. They are realizing that they did not examine thoroughly enough what kind of customization their customers would value before they plunged ahead. That is understandable. Until now, no framework has existed to help managers determine the type of customization they should pursue. James Gilmore and Joseph Pine provide managers with just such a framework. They have identified four distinct approaches to customization. When designing or redesigning a product, process, or business unit, managers should examine each approach for possible insights into how to serve their customers best. In some cases, a single approach will dominate the design. More often, however, managers will need a mix of some or all of the four approaches to serve their own particular set of customers.

  13. Custom-made tumor prosthesis fracture and prosthesis design%定制肿瘤假体断裂因素与假体设计

    Institute of Scientific and Technical Information of China (English)

    荀建军; 李艳芳

    2011-01-01

    背景:因肿瘤型假体置换后并发症而再次手术的患者不断增加,其定制肿瘤假体的断裂是原因之一.目的:总结分析定制肿瘤假体发生断裂的原因,以及其与假体设计的关系.方法:以"定制肿瘤假体,假体断裂"为中文关键词;"Custom-made prosthesis, Endoprosthesis fatigue fracture"为英文关键词.采用计算机检索2000-01/2010-12相关文章.纳入与有关定制肿瘤假体设计及假体断裂翻修相关的文章;排除重复研究或Meta分析类文章.以14篇文献为主重点进行了讨论.结果与结论:假体断裂的原因主要有假体设计缺陷,假体材料、加工工艺不合格,放置失误,手术软组织重建困难及缺少骨支撑等方面.通过了解肿瘤假体应力集中部位及应力峰值,可以预测内固定系统的寿命.%BACKGROUND: The number of patients receiving second operation due to complications after tumor prosthesis replacement is increasing, and custom-made prosthesis fractu re is one of the reasons.OBJECTIVE: To analyze the reasons for custom-made prosthesis fracture, and to investigate their relationship with prosthesisdesign.METHODS: A computer retrieve was performed for related articles published from January 2000 to December 2010 using keywords of "custom-made prosthesis, endoprosthesis fatigue fracture' in Chinese and English. Articles about custom-made prosthesis fracture and design were included. Repetitive articles or Meta analysis were excluded. Totally 14 articles were included in result analysis.RESULTS AND CONCLUSION: The main reasons for prosthesis fracture included design defects, material and process failure,place errors, difficulty in soft tissue reconstruction, and lack of bone support, and so on. The life of fixation system could be predicted based on prosthesis stress site and peak.

  14. SU-E-J-49: Design and Fabrication of Custom 3D Printed Phantoms for Radiation Therapy Research and Quality Assurance

    Energy Technology Data Exchange (ETDEWEB)

    Jenkins, C; Xing, L [Stanford University, Stanford, CA (United States)

    2015-06-15

    Purpose The rapid proliferation of affordable 3D printing techniques has enabled the custom fabrication of items ranging from paper weights to medical implants. This study investigates the feasibility of utilizing the technology for developing novel phantoms for use in radiation therapy quality assurance (QA) procedures. Methods A phantom for measuring the geometric parameters of linear accelerator (LINAC) on-board imaging (OBI) systems was designed using SolidWorks. The design was transferred to a 3D printer and fabricated using a fused deposition modeling (FDM) technique. Fiducials were embedded in the phantom by placing 1.6 mm diameter steel balls in predefined holes and securing them with silicone. Several MV and kV images of the phantom were collected and the visibility and geometric accuracy were evaluated. A second phantom, for use in the experimental evaluation of a high dose rate (HDR) brachytherapy dosimeter, was designed to secure several applicator needles in water. The applicator was fabricated in the same 3D printer and used for experiments. Results The general accuracy of printed parts was determined to be 0.1 mm. The cost of materials for the imaging and QA phantoms were $22 and $5 respectively. Both the plastic structure and fiducial markers of the imaging phantom were visible in MV and kV images. Fiducial marker locations were determined to be within 1mm of desired locations, with the discrepancy being attributed to the fiducial attachment process. The HDR phantom secured the applicators within 0.5 mm of the desired locations. Conclusion 3D printing offers an inexpensive method for fabricating custom phantoms for use in radiation therapy quality assurance. While the geometric accuracy of such parts is limited compared to more expensive methods, the phantoms are still highly functional and provide a unique opportunity for rapid fabrication of custom phantoms for use in radiation therapy QA and research.

  15. Development of novel on-chip, customer-design spiral biasing adaptor on for Si drift detectors and detector arrays for X-ray and nuclear physics experiments

    Science.gov (United States)

    Li, Zheng; Chen, Wei

    2014-11-01

    A novel on-chip, customer-design spiral biasing adaptor (SBA) has been developed. A single SBA is used for biasing a Si drift detector (SDD) and SDD array. The use of an SBA reduces the biasing current. This paper shows the calculation of the geometry of an SBA and an SDD to get the best drift field in the SDD and SDD array. Prototype SBAs have been fabricated to verify the concept. Electrical measurements on these SBAs are in agreement with the expectations. The new SDD array with an SBA can be used for X-ray detection and in nuclear physics experiments.

  16. Development of novel on-chip, customer-design spiral biasing adaptor on for Si drift detectors and detector arrays for X-ray and nuclear physics experiments

    Energy Technology Data Exchange (ETDEWEB)

    Li, Zheng, E-mail: lizheng@xtu.edu.cn [School of Materials, Optoelectronics and Physics, Xiangtan University, Xiangtan, Hunan 411105 (China); Chen, Wei [Brookhaven National Laboratory, Upton, NY 11973 (United States)

    2014-11-21

    A novel on-chip, customer-design spiral biasing adaptor (SBA) has been developed. A single SBA is used for biasing a Si drift detector (SDD) and SDD array. The use of an SBA reduces the biasing current. This paper shows the calculation of the geometry of an SBA and an SDD to get the best drift field in the SDD and SDD array. Prototype SBAs have been fabricated to verify the concept. Electrical measurements on these SBAs are in agreement with the expectations. The new SDD array with an SBA can be used for X-ray detection and in nuclear physics experiments.

  17. Infrared radiant ceramic plaques; Plaques radiantes ceramiques a infrarouge

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2000-05-01

    Infrared plaques developed by MORGAN MATROC can now produce radiant heat from both natural and bottled gas with substantially lower NOx levels, and greater fuel efficiency and cleanliness, than other mass produced gas burning systems. The properties of this ceramic system, in particular very low thermal conductivity, allied to the infrared process for heat conversion, result in efficient radiation of energy. Morgan Matroc now claims half of the world-wide market of infrared plaque. (authors)

  18. Understanding Customer Experience Throughout the Customer Journey

    NARCIS (Netherlands)

    Lemon, Katherine N.; Verhoef, Peter C.

    2016-01-01

    Understanding customer experience and the customer journey over time is critical for firms. Customers now interact with firms through myriad touch points in multiple channels and media, and customer experiences are more social in nature. These changes require firms to integrate multiple business fun

  19. Understanding Customer Experience Throughout the Customer Journey

    NARCIS (Netherlands)

    Lemon, Katherine N.; Verhoef, Peter C.

    2016-01-01

    Understanding customer experience and the customer journey over time is critical for firms. Customers now interact with firms through myriad touch points in multiple channels and media, and customer experiences are more social in nature. These changes require firms to integrate multiple business

  20. Understanding Customer Experience Throughout the Customer Journey

    NARCIS (Netherlands)

    Lemon, Katherine N.; Verhoef, Peter C.

    2016-01-01

    Understanding customer experience and the customer journey over time is critical for firms. Customers now interact with firms through myriad touch points in multiple channels and media, and customer experiences are more social in nature. These changes require firms to integrate multiple business fun

  1. 一种新型客户服务管理平台设计%Design of a new customer service management platform

    Institute of Scientific and Technical Information of China (English)

    陈健瑜

    2016-01-01

    The article introduces platform architecture de⁃sign and logic structure design of a new customer service manage⁃ment, describes the function of the platform. On the basis of the marketing and distribution information integration of the platform, through the remote service channels, the platform establishes man⁃agement pattern and service orientation with efficiency and comple⁃tion and priority to the customer experience perception, which makes up shortcomings for the traditional single and passive man⁃agement mode of customer service. At the same time based on in⁃formation sharing and information interaction, it realizes reserva⁃tion blackouts and power service platform sensitive words early warning monitoring applications. The Foshan pilot project in prac⁃tice shows that the platform provides customers with high quality and efficient service, improves the overall quality of the power sup⁃ply enterprise customer service.%介绍新型客户服务管理平台的架构设计和逻辑结构设计,对平台的功能进行描述。该平台在营配信息集成的基础上,通过远程服务渠道,建立了一套高效完备的、以客户体验感知为主的管理模式和服务导向,弥补了传统单一的客户服务和被动经营模式的不足,同时在生成信息共享和信息互动的基础上,实现预约停电和电力服务平台敏感词预警监控应用。该项目在佛山试点实践表明:平台为客户提供了高质量、高效率的服务,提升了供电企业客户服务的整体素质。

  2. Measuring early plaque formation clinically.

    Science.gov (United States)

    Maliska, Alessandra N; Weidlich, Patricia; Gomes, Sabrina C; Oppermann, Rui V

    2006-01-01

    To test a system of measuring early plaque formation (EPF) and its subgingival extension as related to the presence or absence of a plaque free zone (PFZ). EPF was measured by three independent examiners following two consecutive 72-hour periods of undisturbed plaque build-up. One of the examiners further measured EPF following a 96-hour period in the presence of chlorhexidine or placebo. The classification system was composed of criterion 0 (plaque-free dental surface), criterion 1 (presence of plaque and PFZ) and criterion 2 (absence of PFZ, subgingival extension of plaque). Intra- and inter-examiner reliability were evaluated by means of the percentage of absolute agreement (c), Kappa (k) and Kendall (kd) coefficients. The third experiment consisted of a double-blind, placebo-controlled, cross-over trial. Plaque build-up in the presence of 0.12% chlorhexidine was assessed by employing the classification system described. The percentage of absolute intra- and inter-examiner agreement ranged from 85.43% to 75.63% and from 77.31% to 75.35% respectively. Chlorhexidine and placebo rinses showed similar percentages of criterion 1 surfaces, 62.6% and 51.5% respectively (p = 0.343). Of the surfaces, 44.3% showed criterion 2 after the use of placebo, while 3.4% of surfaces showed this criterion with the chlorhexidine (p = 0.007). The events associated with EPF can be appropriately scored with this classification system. Chlorhexidine rinses inhibit both the plaque colonization of the dental surfaces as well as its subgingival extension.

  3. Modeling customer loyalty using customer lifetime value.

    OpenAIRE

    Glady, N.; Baesens, Bart; Croux, Christophe

    2006-01-01

    The definition and modeling of customer loyalty have been central issues in customer relationship management since many years. Recent papers propose solutions to detect customers that are becoming less loyal, also called churners. The churner status is then defined as a function of the volume of commercial transactions. In the context of a Belgian retail financial service company, our first contribution will be to redefine the notion of customer's loyalty by considering it from a customer-cen...

  4. EVALUATING CUSTOMER-PERCEIVED SERVICE QUALITY AND CUSTOMER SATISFACTION IN THE NIGERIAN BANKING INDUSTRY

    OpenAIRE

    Dr. Moguluwa Shed Chinwuba; Ode Egene

    2013-01-01

    Keeping in view the significance of customer perceived quality in todays competitive banking environment, the study was designed to evaluate customer-perceived service quality and customer satisfaction in the Nigerian banking industry. This research focused on the measurement of customer satisfaction through delivery of service quality in the banking sector in Nigeria. A quantitative research was used to study the relationship between service quality dimensions and customer satisfaction. Find...

  5. Linux下GTK+自定义控件的设计和使用%Design and Use of GTK+ Custom Controls under Linux

    Institute of Scientific and Technical Information of China (English)

    李国玲

    2015-01-01

    GTK+ is a set of graphics tool kit, which provides a variety of interface library elements for user calls. However, the existing interface library elements can only guarantee the basic interface application development, when the user needs to specific features of the interface library elements, design and use of a custom control is particularly important. Combined with working practice, the design and use of the GTK+ custom controls are summarized in order to provide reference for the GTK+ interested in the fans.%GTK+是一套跨多种平台的图形工具包,它提供了多种界面库元素供用户调用。但是,已有的界面库元素仅能保证基础的界面应用程序开发,当用户需要特定功能的界面库元素时,自定义控件的设计和使用就显得尤为重要。结合工作实践,对GTK+自定义控件的设计和使用进行了总结,以期为对GTK+感兴趣的爱好者们提供参考。

  6. Reviewing customer value literature: Comparing and contrasting customer values perspectives

    Directory of Open Access Journals (Sweden)

    Aija Paananen

    2013-09-01

    Full Text Available Purpose: The paper provides a comprehensive and up-to-date literature review of customer value concepts and distinguishes complex customer value from the various perspectives. It structures the themes and dimensions between the various approaches along the customer value main lines in the literature. Design/methodology/approach: The paper reviews current literature and illustrates different types of value representations through a case example. Findings: Based on a comprehensive literature review, a framework how to scholars can structure customer value constructs is presented. Originality/value: In business and management research a conceptual confusion prevails and this paper attempts to clarify different types of customer value to provide a better resolution tool for scholars.

  7. Are loyal customers profitable? : customer satisfaction, customer loyalty and customer profitability at the individual level

    OpenAIRE

    Helgesen, Øyvind

    2000-01-01

    Customer satisfaction is supposed to be positively related to profitability. This conception may be called “the paradigm of customer satisfaction”. Nevertheless, only a few studies have examined this fundamental relationship. Thus, evidence for this “much talked about relationship” is questioned. In this working paper the focus is on the individual customer with respect to the relationships between customer satisfaction, customer loyalty and customer profitability at the customer level. The f...

  8. 基于CMS的属性自定义方案的设计与应用%Design and Application of Attributes Custom Solution Based on CMS

    Institute of Scientific and Technical Information of China (English)

    廖旺胜; 范冰冰

    2013-01-01

    A custom solution for content attributes based on database design and template technology is introduced with the study of content management system and template technology.In this solution,in order to manage and display content better,the content is put into different columns which and whose content model can be defined by user so as to realize the custom of content' s attributes,then the content is custom showed combined with FreeMarker template technology.This solution is used in the intelligent vehicle service system based on mobile internet which obtains good effect.%在研究内容管理系统和模板技术的基础上,本文介绍一种基于数据库设计和模板技术的内容属性自定义方案.为了更好地对内容进行管理和展示,该方案根据内容的属性不同,将内容归类到不同的栏目,用户可以定义自己的栏目及其内容模型,从而实现内容属性的自定义,然后结合FreeMarker模板引擎对内容进行自定义展示.该方案应用于基于移动互联网的智能车载服务系统,取得了良好的效果.

  9. Turning customer satisfaction measurements into action

    OpenAIRE

    Lervik-Olsen, Line; Witell, Lars; Gustafsson, Anders

    2014-01-01

    Purpose – The purpose of this paper is to contribute to the literature on customer orientation by developing and empirically testing a model that attempts to explain the elements that constitute customer orientation and that, in turn, influence customer satisfaction. In particular, this study focuses on how service firms design, collect, analyse and use customer-satisfaction data to improve service performance. This study has the following three research objectives: to understand ...

  10. Turning customer satisfaction measurements into action

    OpenAIRE

    Lervik-Olsen, Line; Witell, Lars; Gustafsson, Anders

    2014-01-01

    Purpose – The purpose of this paper is to contribute to the literature on customer orientation by developing and empirically testing a model that attempts to explain the elements that constitute customer orientation and that, in turn, influence customer satisfaction. In particular, this study focuses on how service firms design, collect, analyse and use customer-satisfaction data to improve service performance. This study has the following three research objectives: to understand ...

  11. Medical image retrieval based on plaque appearance and image registration.

    Science.gov (United States)

    Amores, Jaume; Radeva, Petia

    2005-01-01

    The increasing amount of medical images produced and stored daily in hospitals needs a datrabase management system that organizes them in a meaningful way, without the necessity of time-consuming textual annotations for each image. One of the basic ways to organize medical images in taxonomies consists of clustering them depending of plaque appearance (for example, intravascular ultrasound images). Although lately, there has been a lot of research in the field of Content-Based Image Retrieval systems, mostly these systems are designed for dealing a wide range of images but not medical images. Medical image retrieval by content is still an emerging field, and few works are presented in spite of the obvious applications and the complexity of the images demanding research studies. In this chapter, we overview the work on medical image retrieval and present a general framework of medical image retrieval based on plaque appearance. We stress on two basic features of medical image retrieval based on plaque appearance: plaque medical images contain complex information requiring not only local and global descriptors but also context determined by image features and their spatial relations. Additionally, given that most objects in medical images usually have high intra- and inter-patient shape variance, retrieval based on plaque should be invariant to a family of transformations predetermined by the application domain. To illustrate the medical image retrieval based on plaque appearance, we consider a specific image modality: intravascular ultrasound images and present extensive results on the retrieval performance.

  12. Association between chlamydia pneumoniae infection and carotid atherosclerotic plaques

    Directory of Open Access Journals (Sweden)

    Fereshteh Ashtari

    2007-08-01

    Full Text Available BACKGROUND: Several studies have suggested an association between Chlamydia pneumonia infection and atherosclerosis. This study was designed to investigate the association between this organism and atherosclerotic plaque formation in right and left common carotid arteries (CCAs and extracranial portions of internal carotid arteries (ICAs.
    METHODS: Antibodies to Chlamydia pneumoniae (IgA and IgG were measured and compared in 42 patients who had plaque in at least one CCA or ICA (detected by duplex ultrasound and 82 patients without any plaque in these arteries. Cp.IgG and Cp.IgA titers over 1.10 ISR were defined to be positive.
    RESULTS: We found that 6.1% of control subjects and 16.7% of cases were Cp.IgA seropositive. The difference between these two groups was prominent but was not statistically significant (P = 0.104. 4.2% of females without atherosclerotic plaque and 31.6% of females with plaque were Cp.IgA seropositive. This difference is statistically significant (P = 0.005. There was no significant difference in seropositivity of Cp.IgG between case and control subjects or in male and female groups with or without plaque.
    CONCLUSIONS: Cp.IgA is a predictor of atherosclerosis in women, but Cp.IgG has no predictive value for plaque formation in either gender.
    KEY WORDS: Atherosclerotic plaque, Chlamydia pneumoniae, serum antibody.

  13. Dosimetry of (125)I and (103)Pd COMS eye plaques for intraocular tumors: report of Task Group 129 by the AAPM and ABS.

    Science.gov (United States)

    Chiu-Tsao, Sou-Tung; Astrahan, Melvin A; Finger, Paul T; Followill, David S; Meigooni, Ali S; Melhus, Christopher S; Mourtada, Firas; Napolitano, Mary E; Nath, Ravinder; Rivard, Mark J; Rogers, D W O; Thomson, Rowan M

    2012-10-01

    Dosimetry of eye plaques for ocular tumors presents unique challenges in brachytherapy. The challenges in accurate dosimetry are in part related to the steep dose gradient in the tumor and critical structures that are within millimeters of radioactive sources. In most clinical applications, calculations of dose distributions around eye plaques assume a homogenous water medium and full scatter conditions. Recent Monte Carlo (MC)-based eye-plaque dosimetry simulations have demonstrated that the perturbation effects of heterogeneous materials in eye plaques, including the gold-alloy backing and Silastic insert, can be calculated with reasonable accuracy. Even additional levels of complexity introduced through the use of gold foil "seed-guides" and custom-designed plaques can be calculated accurately using modern MC techniques. Simulations accounting for the aforementioned complexities indicate dose discrepancies exceeding a factor of ten to selected critical structures compared to conventional dose calculations. Task Group 129 was formed to review the literature; re-examine the current dosimetry calculation formalism; and make recommendations for eye-plaque dosimetry, including evaluation of brachytherapy source dosimetry parameters and heterogeneity correction factors. A literature review identified modern assessments of dose calculations for Collaborative Ocular Melanoma Study (COMS) design plaques, including MC analyses and an intercomparison of treatment planning systems (TPS) detailing differences between homogeneous and heterogeneous plaque calculations using the American Association of Physicists in Medicine (AAPM) TG-43U1 brachytherapy dosimetry formalism and MC techniques. This review identified that a commonly used prescription dose of 85 Gy at 5 mm depth in homogeneous medium delivers about 75 Gy and 69 Gy at the same 5 mm depth for specific (125)I and (103)Pd sources, respectively, when accounting for COMS plaque heterogeneities. Thus, the adoption of

  14. Successful marriage: American Panel Corporation and LG Philips LCD custom-designed avionic, shipboard, and rugged ground vehicle display modules from a consumer-oriented fabrication facility

    Science.gov (United States)

    Dunn, William; Garrett, Kimberly S.

    2001-09-01

    American panel corporation (APC) believes the use of custom designed (instead of ruggedized commercial) AMLCD cells is the only way to meet the specific environmental and performance requirements of the military/commercial avionic, shipboard and rugged ground vehicle markets. The APC/LG.Philips LCD (LG) custom approach mitigates risk to the end-user in many ways. As a part of the APC/LG long- term agreement LG has committed to provide module level equivalent (form, fit and function equivalent) panels for a period of ten years. No other commercial glass manufacturer has provided such an agreement. With the use of LG's commercial production manufacturing capabilities, APC/LG can provide the opportunity to procure a lifetime buy for any program with delivery of the entire lot within six months of order placement. This ensures that the entire production program will receive identical glass for every unit. The APC/LG relationship works where others have failed due to the number of years spent cultivating the mutual trust and respect necessary for establishing such a partnership, LG's interest in capturing the market share of this niche application, and the magnitude of the initial up-front investment by APC in engineering, tooling, facilities, production equipment, and LCD cell inventory.

  15. Development of a custom-designed echo particle image velocimetry system for multi-component hemodynamic measurements: system characterization and initial experimental results.

    Science.gov (United States)

    Liu, Lingli; Zheng, Hairong; Williams, Logan; Zhang, Fuxing; Wang, Rui; Hertzberg, Jean; Shandas, Robin

    2008-03-01

    We have recently developed an ultrasound-based velocimetry technique, termed echo particle image velocimetry (Echo PIV), to measure multi-component velocity vectors and local shear rates in arteries and opaque fluid flows by identifying and tracking flow tracers (ultrasound contrast microbubbles) within these flow fields. The original system was implemented on images obtained from a commercial echocardiography scanner. Although promising, this system was limited in spatial resolution and measurable velocity range. In this work, we propose standard rules for characterizing Echo PIV performance and report on a custom-designed Echo PIV system with increased spatial resolution and measurable velocity range. Then we employed this system for initial measurements on tube flows, rotating flows and in vitro carotid artery and abdominal aortic aneurysm (AAA) models to acquire the local velocity and shear rate distributions in these flow fields. The experimental results verified the accuracy of this technique and indicated the promise of the custom Echo PIV system in capturing complex flow fields non-invasively.

  16. Development of a custom-designed echo particle image velocimetry system for multi-component hemodynamic measurements: system characterization and initial experimental results

    Energy Technology Data Exchange (ETDEWEB)

    Liu Lingli; Zheng Hairong; Williams, Logan; Zhang Fuxing; Wang Rui; Hertzberg, Jean; Shandas, Robin [Department of Mechanical Engineering, University of Colorado, Boulder, CO 80309-0427 (United States)], E-mail: Robin.shandas@colorado.edu

    2008-03-07

    We have recently developed an ultrasound-based velocimetry technique, termed echo particle image velocimetry (Echo PIV), to measure multi-component velocity vectors and local shear rates in arteries and opaque fluid flows by identifying and tracking flow tracers (ultrasound contrast microbubbles) within these flow fields. The original system was implemented on images obtained from a commercial echocardiography scanner. Although promising, this system was limited in spatial resolution and measurable velocity range. In this work, we propose standard rules for characterizing Echo PIV performance and report on a custom-designed Echo PIV system with increased spatial resolution and measurable velocity range. Then we employed this system for initial measurements on tube flows, rotating flows and in vitro carotid artery and abdominal aortic aneurysm (AAA) models to acquire the local velocity and shear rate distributions in these flow fields. The experimental results verified the accuracy of this technique and indicated the promise of the custom Echo PIV system in capturing complex flow fields non-invasively.

  17. On the Origin of Bronze Belt Plaques of Ancient Nomads in Northern China

    Institute of Scientific and Technical Information of China (English)

    WUEn; 丁小雷

    2003-01-01

    The bronze plaques decorated with animal, human or geometric designs were the ornaments on the leather belts of the nomadic people, such as Xiongnu (Hun) and Xianbei (Sienpi) in Northern China in the Qin and Han Dynasties. These plaques had unique regional and ethnical characteristics. There have been many different ideas on the origination of this kind of plaques. The author plans to give his own opinion hereby on this issue.

  18. Talking about Customer Service.

    Science.gov (United States)

    Talley, Mary; Axelroth, Joan

    2001-01-01

    Discusses customer service in information centers and how to define it. Topics include the effects of competition, that give customers more choices; defining customers, and defining services; communications; physical environment; change, in customers and in technology; measuring customer service; and evaluating policies and procedures. (LRW)

  19. Mass Customization Services

    DEFF Research Database (Denmark)

    Friedrich, Gerhard

    Topics of the IMCM’08 & PETO’08 and this book are: Mass customization in service, mass customizing financial services, mass customization in supply networks, implementation issues in logistics, product life cycle and mass customization. The research field of mass customization is more than 15 years...

  20. Denitrification in human dental plaque

    Directory of Open Access Journals (Sweden)

    Verstraete Willy

    2010-03-01

    Full Text Available Abstract Background Microbial denitrification is not considered important in human-associated microbial communities. Accordingly, metabolic investigations of the microbial biofilm communities of human dental plaque have focused on aerobic respiration and acid fermentation of carbohydrates, even though it is known that the oral habitat is constantly exposed to nitrate (NO3- concentrations in the millimolar range and that dental plaque houses bacteria that can reduce this NO3- to nitrite (NO2-. Results We show that dental plaque mediates denitrification of NO3- to nitric oxide (NO, nitrous oxide (N2O, and dinitrogen (N2 using microsensor measurements, 15N isotopic labelling and molecular detection of denitrification genes. In vivo N2O accumulation rates in the mouth depended on the presence of dental plaque and on salivary NO3- concentrations. NO and N2O production by denitrification occurred under aerobic conditions and was regulated by plaque pH. Conclusions Increases of NO concentrations were in the range of effective concentrations for NO signalling to human host cells and, thus, may locally affect blood flow, signalling between nerves and inflammatory processes in the gum. This is specifically significant for the understanding of periodontal diseases, where NO has been shown to play a key role, but where gingival cells are believed to be the only source of NO. More generally, this study establishes denitrification by human-associated microbial communities as a significant metabolic pathway which, due to concurrent NO formation, provides a basis for symbiotic interactions.

  1. Creating customer loyalty through service customization

    NARCIS (Netherlands)

    Coelho, Pedro S.; Henseler, Jörg

    2012-01-01

    Purpose – Although practitioners and scholars alike embrace service customization as a possibly powerful management instrument, its impact on customer relationships as well as contingencies for its effective application are not well understood. Drawing from relationship marketing and exchange theory

  2. Analysis and Design on the Customer Service Management Module in Customer Relationship Management---Taking the Logistics Industry for Example%客户关系管理中客户服务管理系统的分析与设计--以物流行业为例

    Institute of Scientific and Technical Information of China (English)

    谢宏武

    2013-01-01

    物流行业客户关系管理中的客户服务管理信息系统,是现代化和信息化物流企业开展客户服务不可缺少的组成部分,该系统的内容对于物流企业、客户和服务人员来说都至关重要。本文根据客户关系系统中客户服务领域的现状,结合现代经济环境对客户服务提出的新要求进行系统分析,并提出整体设计方案。%Customer service management system in logistics industry is an indispensable part for logistics enterprises of modernization and informatization to develop customer service,which is also crucial to the customers and service personnels. Based on the status of customer service in customer relationship system,this paper analyzes the new requirements of customer service in modern economic environment,and proposes the overall design.

  3. The Self-Leading Customer

    DEFF Research Database (Denmark)

    Sørensen, Kirsten Bonde

    2012-01-01

    This paper refers to a Ph.D. design research, conducted in a medium sized Danish bank. The research demonstrates a human-centred perspective and resulted in a radical new type of banking service represented in the MoneyWorkshop. The MoneyWorkshop helps customers uncover their dominant values...... and emotions and makes them increasingly aware of their preferred personal values related to money. Participation in this workshop made customers increasingly empowered and ‘self-leading’. People even changed their ‘money behaviour’ – now in accordance with their values. The paper explains the Money......-Leading Customer...

  4. Custom fractional factorial designs to develop atorvastatin self-nanoemulsifying and nanosuspension delivery systems--enhancement of oral bioavailability

    National Research Council Canada - National Science Library

    Hashem, Fahima M; Al-Sawahli, Majid M; Nasr, Mohamed; Ahmed, Osama A A

    2015-01-01

    ...) and solid nanosuspensions (NS) in order to enhance the oral delivery of atorvastatin (ATR). According to the design, 14 experimental runs of ATR SNEDDS were formulated utilizing the highly ATR solubilizing SNEDDS components...

  5. Plaque control and oral hygiene methods

    LENUS (Irish Health Repository)

    Harrison, Peter

    2017-06-01

    The experimental gingivitis study of Löe et al.1 demonstrated a cause and effect relationship between plaque accumulation and gingival inflammation, and helped to establish plaque\\/biofilm as the primary risk factor for gingivitis. When healthy individuals withdrew oral hygiene efforts, gingival inflammation ensued within 21 days in all subjects. Once effective plaque removal was recommenced, clinical gingival health was quickly re-established – indicating that plaque-associated inflammation is modifiable by plaque control. As current consensus confirms that gingivitis and periodontitis may be viewed as a continuum of disease,2 the rationale for achieving effective plaque control is clear.

  6. Dimensional accuracy of two rubber base impression materials as a function of spacer design and techniques in custom trays for fixed partial dentures

    Science.gov (United States)

    Kaushik, Pankaj; Dhiman, R.K.; Kumar, Dinesh

    2015-01-01

    Background A prostheses can't be better than the cast over which it has been fabricated. To make accurate casts, accurate impressions are mandatory. To get an accurate and dimensionally stable impression, various techniques and materials have been advocated. This study compares the most commonly used techniques and materials for dimensional accuracy. Two types of spacers were designed to compare the addition silicon and polyether and their techniques. Methods A metal die was used to make the impressions. A total of 60 impressions were made using multiple mix and monophasic techniques for addition silicon and polyether in custom trays. A travelling microscope was used to measure the dimensional accuracy of die stone casts retrieved from impressions. Results The results were compared using paired t test and SPSS software. The study was highly significant (p silicon and spacer design I (adapted to the edentulous area) was more accurate than the design II (spacer over the abutments, not adapted to edentulous area). The multiple mix technique was more accurate than the monophasic for addition silicon. Conclusion The combination of multiple mix technique with spacer design I for addition silicon gave the best accurate results. PMID:26843746

  7. Customer Requirements Mapping Method Based on Association Rule Mining for Mass Customization

    Institute of Scientific and Technical Information of China (English)

    XIA Shi-sheng; WANG Li-ya

    2008-01-01

    Customer requirements analysis is the key step for product variety design of mass customiza-tion(MC). Quality function deployment (QFD) is a widely used management technique for understanding thevoice of the customer (VOC), however, QFD depends heavily on human subject judgment during extractingcustomer requirements and determination of the importance weights of customer requirements. QFD pro-cess and related problems are so complicated that it is not easily used. In this paper, based on a generaldata structure of product family, generic bill of material (CBOM), association rules analysis was introducedto construct the classification mechanism between customer requirements and product architecture. The newmethod can map customer requirements to the items of product family architecture respectively, accomplishthe mapping process from customer domain to physical domain directly, and decrease mutual process betweencustomer and designer, improve the product design quality, and thus furthest satisfy customer needs. Finally,an example of customer requirements mapping of the elevator cabin was used to illustrate the proposed method.

  8. Surveying your internal customers.

    Science.gov (United States)

    Weir, V L

    1998-06-01

    Internal customers often are overlooked when business techniques are applied. By applying common external customer satisfaction survey techniques to internal business functions, one hospital identified areas for improvement.

  9. King customer forever: Customer satisfaction and beyond

    Directory of Open Access Journals (Sweden)

    Myuers James

    2004-01-01

    Full Text Available "King Customer!" So proclaimed the front cover of Business Week in a 1989 issue. At about the same time, "Rediscovering the Customer" was the title of a series of company vignettes in Fortune magazine. And a Wall Street Journal article asked, "For Customers, More Than Lip Service?" Combined, these three prestigious business publications reflected a new era in business firms perceptions of their customers and the role they should play in the formulation of company strategies and priorities. Had the "Era of the Customer" finally arrived in American business? .

  10. Engineering specification and system design for CAD/CAM of custom shoes. Phase 5: UMC involvement (January 1, 1989 - June 30, 1989)

    Science.gov (United States)

    Bao, Han P.

    1989-01-01

    The CAD/CAM of custom shoes is discussed. The solid object for machining is represented by a wireframe model with its nodes or vertices specified systematically in a grid pattern covering its entire length (point-to-point configuration). Two sets of data from CENCIT and CYBERWARE were used for machining purposes. It was found that the indexing technique (turning the stock by a small angle then moving the tool on a longitudinal path along the foot) yields the best result in terms of ease of programming, savings in wear and tear of the machine and cutting tools, and resolution of fine surface details. The work done using the LASTMOD last design system results in a shoe last specified by a number of congruent surface patches of different sizes. This data format was converted into a form amenable to the machine tool. It involves a series of sorting algorithms and interpolation algorithms to provide the grid pattern that the machine tool needs as was the case in the point to point configuration discussed above. This report also contains an in-depth treatment of the design and production technique of an integrated sole to complement the task of design and manufacture of the shoe last. Clinical data and essential production parameters are discussed. Examples of soles made through this process are given.

  11. Design and implementation of online system for customer satisfaction degree survey%用户满意度在线调查系统设计与实现

    Institute of Scientific and Technical Information of China (English)

    杨省伟

    2015-01-01

    Through the need analysis of the online system for customer satisfaction degree survey for a fa-mous brand products,we study the key techniques. In the design of the system,we enhance the reliability and stability of operation in case of large-scale access on the one hand;and on the other hand we try to prevent malicious attacks such as machine voting. Based on the B/S architecture,we have adopted the de-sign idea of the hierarchical design and modularization,and then managed to construct the system. The system has achieved good effect in practice,and achieved the expected goal.%通过对某省名牌产品网上满意度调查系统的需求分析,确定了系统的设计方案。在系统设计上,一方面增强在大规模访问下运行的可靠性与稳定性,同时防止机器刷票等恶意攻击行为。最后,基于B/S架构,采取分层设计思想与模块化实现的思路,完成了系统的构建。该系统在实际运行中取得了良好效果,达到了预期目标。

  12. En plaque meningioma with angioinvasion

    Directory of Open Access Journals (Sweden)

    Basu Keya

    2010-04-01

    Full Text Available En plaque meningioma is a rare type of meningioma characterized by infiltrative nature, sheet-like growth and at times invading the bone. We report here a case of en plaque meningioma with typical grade I histomorphology along with unusual feature of angioinvasion. The patient was a 55-year-old man presenting with headache and painful proptosis of right eye. Imaging modalities revealed an en -plaque meningioma extending into the right sylvian fissure, with thickening of right temporal calvarium, greater wing of sphenoid and extension into the orbit. Magnetic resonance angiography showed medial displacement of right middle cerebral artery. The tumor was removed from the sylvian fissure and right temporal convexity. However, only subtotal removal of the intraorbital part was possible. Histology showed a meningothelial meningioma with low tumor cell proliferation, but infiltration into the bone, skeletal muscle and angioinvasion. Recognition of meningiomas en plaque is useful, as these tumors are difficult to resect completely, and are more prone to undergo recurrence or malignant change. In addition, angioinvasion seen in this tumor may have additional prognostic significance.

  13. E-CUSTOMS PROGRAMME - NEW QUALITY OF SERVICES PROVIDED BY CUSTOMS ADMINISTRATIONS TO EUROPEAN BUSINESS

    Directory of Open Access Journals (Sweden)

    Małgorzata Czermińska

    2016-09-01

    Full Text Available E-Customs initiative includes a number of IT projects, organizational and legal measures. They are designed to creation of a simple and paperless environment for trade and customs, to short the duration of customs clearance and to ensure an appropriate level of security of commercial transactions. Modern customs administration must operate on the basis of advanced infrastructure in the field of information and communication technologies. Only then will it be able to provide cheaper and more efficient customs services. Therefore, the greatest challenge and the main goal of the e-Customs programme is to harmonize customs procedures and systems in the 28 Member States. The article describes the assumptions and objectives of the e-Customs, presents its genesis and evolution. Particular attention was paid to the activities that are aimed at improving the quality of customs services provided to European companies.

  14. 基于XMPP的在线客服系统设计与实现%Design and Implementation of Online Customer Service System Based on XMPP

    Institute of Scientific and Technical Information of China (English)

    李丽; 陆良虎; 闰荞荞; 马燕; 何晓庆

    2012-01-01

    建立基于XMPP的在线客户服务系统,可以突破目前通讯系统各异产生的互不兼容,实现多种资讯服务平台的信息融合与不同服务系统之间互联互通,不断地拓宽企业的业务范围;对几种较为典型的IM系统通讯功能的特性与优缺点进行分析,在此基础上对在线客服系统进行设计与实现;在线客服系统接通信功能层、业务应用层和企业管理系统层进行构建,其服务器端的实现采取基于Openfire的WebService服务,实现了用户登录验证与组间转接、非工作日判定、坐席分配调度等功能;相应用户端实现服务请求、信息获取、及多种通讯等功能;系统可较好的解决异构IM系统之间通讯,满足在线客户服务功能需求.%Based on XMPP, an online customer services system was established , which can break through the incompatible induced by the differences of current communications systems, integrate information form different information service platform, and achieve intercon-nectivity between the various services system. As a result, it can expand the range of enterprise services. This paper first makes a comparison on several typical IM system for their strengths and weaknesses. The online customer services system is designed and implemented, which is composed of communication, business application and enterprise management layers. The server side is implemented using the webservice of Openfire, it has the functions of user authentication login, group transfers, non- business days judgment, the seating assignment scheduling and so on, And the client side has the functions of service requests , information obtaining and multiply communication ways. The System can solve the communication between disparate instant messaging systems, and meet the needs of online customer service functions.

  15. Ultrasound Tissue Characterization of Vulnerable Atherosclerotic Plaque

    Directory of Open Access Journals (Sweden)

    Eugenio Picano

    2015-05-01

    Full Text Available A thrombotic occlusion of the vessel fed by ruptured coronary atherosclerotic plaque may result in unstable angina, myocardial infarction or death, whereas embolization from a plaque in carotid arteries may result in transient ischemic attack or stroke. The atherosclerotic plaque prone to such clinical events is termed high-risk or vulnerable plaque, and its identification in humans before it becomes symptomatic has been elusive to date. Ultrasonic tissue characterization of the atherosclerotic plaque is possible with different techniques—such as vascular, transesophageal, and intravascular ultrasound—on a variety of arterial segments, including carotid, aorta, and coronary districts. The image analysis can be based on visual, video-densitometric or radiofrequency methods and identifies three distinct textural patterns: hypo-echoic (corresponding to lipid- and hemorrhage-rich plaque, iso- or moderately hyper-echoic (fibrotic or fibro-fatty plaque, and markedly hyperechoic with shadowing (calcific plaque. Hypoechoic or dishomogeneous plaques, with spotty microcalcification and large plaque burden, with plaque neovascularization and surface irregularities by contrast-enhanced ultrasound, are more prone to clinical complications than hyperechoic, extensively calcified, homogeneous plaques with limited plaque burden, smooth luminal plaque surface and absence of neovascularization. Plaque ultrasound morphology is important, along with plaque geometry, in determining the atherosclerotic prognostic burden in the individual patient. New quantitative methods beyond backscatter (to include speed of sound, attenuation, strain, temperature, and high order statistics are under development to evaluate vascular tissues. Although not yet ready for widespread clinical use, tissue characterization is listed by the American Society of Echocardiography roadmap to 2020 as one of the most promising fields of application in cardiovascular ultrasound imaging

  16. Validation and Application of a Custom-Designed Targeted Next-Generation Sequencing Panel for the Diagnostic Mutational Profiling of Solid Tumors.

    Science.gov (United States)

    Froyen, Guy; Broekmans, An; Hillen, Femke; Pat, Karin; Achten, Ruth; Mebis, Jeroen; Rummens, Jean-Luc; Willemse, Johan; Maes, Brigitte

    2016-01-01

    The inevitable switch from standard molecular methods to next-generation sequencing for the molecular profiling of tumors is challenging for most diagnostic laboratories. However, fixed validation criteria for diagnostic accreditation are not in place because of the great variability in methods and aims. Here, we describe the validation of a custom panel of hotspots in 24 genes for the detection of somatic mutations in non-small cell lung carcinoma, colorectal carcinoma and malignant melanoma starting from FFPE sections, using 14, 36 and 5 cases, respectively. The targeted hotspots were selected for their present or future clinical relevance in solid tumor types. The target regions were enriched with the TruSeq approach starting from limited amounts of DNA. Cost effective sequencing of 12 pooled libraries was done using a micro flow cell on the MiSeq and subsequent data analysis with MiSeqReporter and VariantStudio. The entire workflow was diagnostically validated showing a robust performance with maximal sensitivity and specificity using as thresholds a variant allele frequency >5% and a minimal amplicon coverage of 300. We implemented this method through the analysis of 150 routine diagnostic samples and identified clinically relevant mutations in 16 genes including KRAS (32%), TP53 (32%), BRAF (12%), APC (11%), EGFR (8%) and NRAS (5%). Importantly, the highest success rate was obtained when using also the low quality DNA samples. In conclusion, we provide a workflow for the validation of targeted NGS by a custom-designed pan-solid tumor panel in a molecular diagnostic lab and demonstrate its robustness in a clinical setting.

  17. Red autofluorescence of dental plaque bacteria

    NARCIS (Netherlands)

    van der Veen, M. H.; Thomas, R. Z.; Huysmans, M. C. D. N. J. M.; de Soet, J. J.

    2006-01-01

    Red autofluorescence of plaque and its relation to fluorescence of a single species in the biofilm was studied. Fluorescence images of non-disclosed and disclosed plaque of 28 first-year students were captured. The plaque samples were assessed by culture methods and studied for red autofluorescence.

  18. Design and performance of a custom ASIC digitizer for wire chamber readout in 65 nm CMOS technology

    Science.gov (United States)

    Lee, M. J.; Brown, D. N.; Chang, J. K.; Ding, D.; Gnani, D.; Grace, C. R.; Jones, J. A.; Kolomensky, Y. G.; von der Lippe, H.; Mcvittie, P. J.; Stettler, M. W.; Walder, J.-P.

    2015-06-01

    We present the design and performance of a prototype ASIC digitizer for integrated wire chamber readout, implemented in 65 nm commercial CMOS technology. Each channel of the 4-channel prototype is composed of two 16-bit Time-to-Digital Converters (TDCs), one 8-bit Analog-to-Digital Converter (ADC), a front-end preamplifier and shaper, plus digital and analog buffers that support a variety of digitization chains. The prototype has a multiplexed digital backend that executes a state machine, distributes control and timing signals, and buffers data for serial output. Laboratory bench tests measure the absolute TDC resolution between 74 ps and 480 ps, growing with the absolute delay, and a relative time resolution of 19 ps. Resolution outliers due to cross-talk between clock signals and supply or reference voltages are seen. After calibration, the ADC displays good linearity and noise performance, with an effective number of bits of 6.9. Under normal operating conditions the circuit consumes 32 mW per channel. Potential design improvements to address the resolution drift and tails are discussed.

  19. The molecular concept of atheromatous plaques.

    Science.gov (United States)

    Thent, Zar Chi; Chakraborty, Chiranjib; Mahakkanukrauh, Pasuk; Kosai, Nik; Rajan, Reynu; Das, Srijit

    2016-05-02

    Recently, there are scientific attempts to devise new drugs in the biotechnology industry in order to treat various diseases including atherosclerosis. Atherosclerosis is considered to be a leading cause of death throughout the world. Atherosclerosis involves oxidative damage to the cells with production of reactive oxygen species (ROS). Development of atheromatous plaques in the arterial wall is a common feature. Specific inflammatory markers pertaining to the arterial wall in atherosclerosis may be useful for both diagnosis and treatment. These include macrophage inhibiting factor (MIF), leucocytes and P-selectin. Modern therapeutic paradigms involving endothelial progenitor cells therapy, angiotensin II type-2 (AT2R) and ATP-activated purinergic receptor therapy are notable to mention. Future drugs may be designed aiming three signalling mechanisms of AT2R which are (a) activation of protein phosphatases resulting in protein dephosphorylation (b) activation of bradykinin/nitric oxide/cyclic guanosine 3',5'-monophosphate pathway by vasodilation and (c) stimulation of phospholipase A(2) and release of arachidonic acid. Drugs may also be designed to act on ATP-activated purinergic receptor channel type P2X7 molecules which acts on cardiovascular system. In the present review, we discuss the molecular concept of the inflammatory process occurring inside the arterial wall. Better understanding of the vascular inflammatory processes and the cells involved in the formation of plaques, may prove to be beneficial for future diagnosis, clinical treatment and planning innovative novel anti-atherosclerotic drugs.

  20. A Data Mining Technique to Find Optimal Customers for Beneficial Customer Relationship Management

    Directory of Open Access Journals (Sweden)

    T. Bhuvaneswari

    2012-01-01

    Full Text Available Problem statement: Modern companies and organizations are efficiently implementing a CRM strategy for managing a company interactions and relationships with customers. CRM systems have been developed and designed to support the areas of marketing, service process and sales. Many literature studies are available to preserve the customer relationship but small drawbacks occur in the existing methods. One method to maintain the customer relationship is frequency based method i.e., the company will give declination to the customer based on the historical data that is the customers how many times come to that company. These methods are not effective. Because the customers give revenue to that company is less. So the company revenue is affected. Approach: In this study, we propose a data mining and artificial technique to maintain the customer relationship between company and customers. Accomplishing this process, we maintain a historical database and then we use data mining ARM technique to mine the customer information from this database. We then present an artificial intelligence PSO technique to provide an offer to the selected customers. This offer does not affect the company revenues as well as satisfies the customers. This process will make a best relationship between the customers and organization and to satisfy the customers forever with company’s rules. Results: he simulation results have shown the performance of apriori algorithm for diverse combination of profit lengths of each customer. The performance of selected customer has been analyzed for five years. Finally the comparison results shows the selected customers are optimal comparing to other customers. Conclusion: The proposed method optimally selects the customers and also avoids the problems in the earliest methods. So, the relationship between customer and company is maintained successfully by using the proposed method.

  1. Customer satisfaction and competencies

    DEFF Research Database (Denmark)

    Gritti, Paola; Foss, Nicolai Juul

    this by analyzing data collected on 2,105 customers of 118 branches of one of the biggest banks of an Italian banking group. We find that customer satisfaction impacts loyalty, which in turn has a direct effect on financial and non-financial customer value/total customer value/complex customer value. Moreover......We empirically address how customer satisfaction and loyalty in the banking industry may affect profitability. This helps to identify the strategy and competencies necessary to benefit from customer relationships which are important sources for improved performance in the banking. We do...

  2. Modeling the customer in electronic commerce.

    Science.gov (United States)

    Helander, M G; Khalid, H M

    2000-12-01

    This paper reviews interface design of web pages for e-commerce. Different tasks in e-commerce are contrasted. A systems model is used to illustrate the information flow between three subsystems in e-commerce: store environment, customer, and web technology. A customer makes several decisions: to enter the store, to navigate, to purchase, to pay, and to keep the merchandize. This artificial environment must be designed so that it can support customer decision-making. To retain customers it must be pleasing and fun, and create a task with natural flow. Customers have different needs, competence and motivation, which affect decision-making. It may therefore be important to customize the design of the e-store environment. Future ergonomics research will have to investigate perceptual aspects, such as presentation of merchandize, and cognitive issues, such as product search and navigation, as well as decision making while considering various economic parameters. Five theories on e-commerce research are presented.

  3. THROUGH THE EYE OF THE CUSTOMER : A STUDY OF HOW CORPORATE BRAND IMAGE IMPACT CUSTOMER LOYALTY AND CUSTOMER SATISFACTION IN THE TRAVEL INDUSTRY

    OpenAIRE

    Ekorn, Stephanie; Khan, Silvia

    2014-01-01

    An important question in today’s research on marketing is in what way a company can influence how customers perceive their brand and in what way they can facilitate customer retention. The aim with this paper is to research the impact the corporate brand image has on customer satisfaction and customer loyalty within the travel industry to further the understanding of how branding activities influence customer preferences. By using a survey with an experimental design, where corporate brand im...

  4. THROUGH THE EYE OF THE CUSTOMER : A STUDY OF HOW CORPORATE BRAND IMAGE IMPACT CUSTOMER LOYALTY AND CUSTOMER SATISFACTION IN THE TRAVEL INDUSTRY

    OpenAIRE

    Ekorn, Stephanie; Khan, Silvia

    2014-01-01

    An important question in today’s research on marketing is in what way a company can influence how customers perceive their brand and in what way they can facilitate customer retention. The aim with this paper is to research the impact the corporate brand image has on customer satisfaction and customer loyalty within the travel industry to further the understanding of how branding activities influence customer preferences. By using a survey with an experimental design, where corporate brand im...

  5. 移动网络客户服务支撑系统架构设计与实现%Architecture Designing and Implementation of Mobile Network Customer Service Support System

    Institute of Scientific and Technical Information of China (English)

    孟照方; 郭景赞; 李德屹

    2013-01-01

    Based on the issues on the customer service complaint handling, it presents the overal architecture, the technical architecture, the interface designing and the functional architecture in the construction of mobile network customer service support system as wel as the key technologies on software design, to provide reference for the construction of mobile network customer ser-vice support system.%  从客户服务投诉处理存在的实际问题出发,提出了移动网络客户服务支撑系统建设过程中的总体架构、技术架构、接口设计、功能架构以及软件设计过程中使用的关键技术,为移动网络客户服务支撑系统的建设提供了指导方法。

  6. Preliminary Study of In Vivo Formed Dental Plaque Using Confocal Microscopy and Scanning Electron Microscopy

    Directory of Open Access Journals (Sweden)

    KA. Al-Salihi

    2009-12-01

    Full Text Available Objective: Confocal laser scanning microscopy (CLSM is relatively a new light microscopical imaging technique with a wide range of applications in biological sciences. The primary value of CLSM for the biologist is its ability to provide optical sections from athree-dimensional specimen. The present study was designed to assess the thickness and content of in vivo accumulated dental plaque using CLSM and scanning electron microscopy (SEM.Materials and Methods: Acroflat lower arch splints (acrylic appliance were worn by five participants for three days without any disturbance. The formed plaques were assessed using CLSM combined with vital fluorescence technique and SEM.Results: In this study accumulated dental plaque revealed varied plaque microflora vitality and thickness according to participant’s oral hygiene. The thickness of plaque smears ranged from 40.32 to 140.72 μm and 65.00 to 128.88 μm for live (vital and dead accumulated microorganisms, respectively. Meanwhile, the thickness of plaque on the appliance ranged from 101 μm to 653 μm. CLSM revealed both dead and vital bacteria on the surface of the dental plaque. In addition, SEM revealed layers of various bacterial aggregations in all dental plaques.Conclusion: This study offers a potent non-invasive tool to evaluate and assess the dental plaque biofilm, which is a very important factor in the development of dental caries.

  7. Customer-Centered Product Design System——Taking Sofa Product as an Example%以客户为中心的产品设计系统——以沙发产品为例

    Institute of Scientific and Technical Information of China (English)

    刘茜; 潘荣

    2011-01-01

    以沙发产品设计过程为例,模块化构建面向客户的在线产品设计系统,真正体现以客户为中心的设计理念.该系统前端以RIA作为展现层从而实现逼真的展示效果,以Flexlib作为组件设计包,后端以Spring作为AOP和IoC工具、以Degrafa作为图形引擎,采用BlazeDS实现前端与后端的通讯.由此搭建供客户自助设计和供设计师专业设计的协同工作环境.%Customer oriented Web-based modular product design system can demonstrate customer-centered design concept. The sofa design system is chosen as a sample to show how to make this be a reality. This system uses RIA as client solution which can make the user interface more lively, chooses Flexlib as component library. Spring is selected as AOP and IoC solution in the backend. Degrafa as the graphics engine, BlazeDS is chosen to make the communication between frontend and backend. So a cooperative operation environment for both customer and professional designer can be established. And the customer can self-design their style's sofa in this environment.

  8. Design and Performance of a Custom ASIC Digitizer for Wire Chamber Readout in 65 nm CMOS Technology

    CERN Document Server

    Lee, MyeongJae; Chang, Jessica K; Ding, Dawei; Gnani, Dario; Grace, Carl R; Jones, John A; Kolomensky, Yury G; von der Lippe, Henrik; Mcvittie, Patrick J; Stettler, Matthew W; Walder, Jean-Pierre

    2015-01-01

    We present the design and performance of a prototype ASIC digitizer for integrated wire chamber readout, implemented in 65 nm commercial CMOS technology. Each channel of the 4-channel prototype is composed of two 16-bit Time-to-Digital Converters (TDCs), one 8-bit Analog-to-Digital Converter (ADC), a front-end preamplifier and shaper, plus digital and analog buffers that support a variety of digitization chains. The prototype has a multiplexed digital backend that executes a state machine, distributes control and timing signals, and buffers data for serial output. Laboratory bench tests measure the absolute TDC resolution between 74 ps and 480 ps, growing with the absolute delay, and a relative time resolution of 19 ps. Resolution outliers due to cross-talk between clock signals and supply or reference voltages are seen. After calibration, the ADC displays good linearity and noise performance, with an effective number of bits of 6.9. Under normal operating conditions the circuit consumes 32 mW per channel. Po...

  9. 面向组织客户的客户价值评价体系设计%The Design of Value Assessment System of Organizational Customer

    Institute of Scientific and Technical Information of China (English)

    赵宛婧; 齐佳音

    2012-01-01

    客户根据其是否具有组织特性而分为个人客户和组织客户,组织客户对于一个企业的重要性和战略意义越来越不容忽视.而目前关于客户价值评价方法的研究没有明确其对象,由于个人客户与组织客户在许多方面存在较大差异,因此本文将针对组织客户提出客户价值评价方法,将在前人研究的基础上从直接价值和间接价值两个角度给出组织客户价值评价体系,并通过专家访谈修正该体系,主要从组织自身和其所在网络两个角度进行分析,丰富和完善组织客户间接价值评价维度.%Customers can be divided into individual customers and organizational customers according to their characteristics. The importance and strategic significance of organizational customers for a business should not be overlooked. The current evaluation method on customer value research does not specify its object, whereas there are differences between individual customers and organizational customer in many ways. Hence, this research will focus on organizational customers to study customer evaluation method which is based on previous studies from two angles: direct value and indirect value. The main contribution of this research is to enrich and improve the customer indirect valuation dimensions, by analyzing from the organizational itself and network effect.

  10. Customer satisfaction and competencies

    DEFF Research Database (Denmark)

    Gritti, Paola; Foss, Nicolai Juul

    this by analyzing data collected on 2,105 customers of 118 branches of one of the biggest banks of an Italian banking group. We find that customer satisfaction impacts loyalty, which in turn has a direct effect on financial and non-financial customer value/total customer value/complex customer value. Moreover......, loyalty is a mediator between financial and not-financial customer value and two sources of customer satisfaction, namely relationships with the front office and the branch, on the one hand, and the products offered, on the other.......We empirically address how customer satisfaction and loyalty in the banking industry may affect profitability. This helps to identify the strategy and competencies necessary to benefit from customer relationships which are important sources for improved performance in the banking. We do...

  11. Fabrication and characterization of selective laser melting printed Ti–6Al–4V alloys subjected to heat treatment for customized implants design

    Directory of Open Access Journals (Sweden)

    Mengke Wang

    2016-12-01

    Full Text Available Selective laser melting (SLM is a promising technique capable of rapidly fabricating customized implants having desired macro- and micro-structures by using computer-aided design models. However, the SLM-based products often have non-equilibrium microstructures and partial surface defects because of the steep thermal gradients and high solidification rates that occur during the laser melting. To meet clinical requirements, a heat treatment was used to tailor the physiochemical properties, homogenize the metallic microstructures, and eliminate surface defects, expecting to improve the cytocompatibility in vitro. Compared with the as-printed Ti–6Al–4V substrate, the heat-treated substrate had a more hydrophilic, rougher and more homogeneous surface, which should promote the early cell attachment, proliferation and osseointegration. More importantly, a crystalline rutile TiO2 layer formed during the heat treatment, which should greatly promote the biocompatibility and corrosion resistance of the implant. Compared to the untreated surfaces, the adhesion and proliferation of human bone mesenchymal stem cells (hBMSCs on heat-treated substrates were significantly enhanced, implying an excellent cytocompatibility after annealing. Therefore, these findings provide an alternative to biofunctionalized SLM-based Ti–6Al–4V implants with optimized physiochemical properties and biocompatibility for orthopedic and dental applications.

  12. Agility Evaluation of Mass Customization Product Manufacturing

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Mass Customization (MC) is one of the importance en te rprise produces modes in information age progressively. Mass Customization produ ct manufacturing is aimed at the objection of agile responding to customer deman d, market changing and market opportunities to combine with modern management te chnology and advanced manufacture technology, and to use the development model o f design for product family and technology concurrent. Therefore, in the environ ment of market continuing to change with a high spee...

  13. Customer participation in service production and delivery system

    OpenAIRE

    Sridhar, M. S.

    1998-01-01

    Highlights significance of designing service delivery system, explains the integral role of customer in service production process, stresses the importance of customer-organisation interface, lists important ingredients of service package to be considered while designing customer interface, enumerates various dimensions of customer interface which can be positively made use of in design of service production and delivery system, discusses various ways and means of inducing and enhancing custo...

  14. 多FIFO灵活定制SDRAM控制器设计%Flexibly Customized Multi-channel FIFO Design for SDRAM Controller

    Institute of Scientific and Technical Information of China (English)

    丁国栋; 刘昌华

    2014-01-01

    This paper proposes a simple and lfexibly customized asynchronous FIFO for SDRAM control er based on FPGA,it solves the problem that the SDRAM control er design is complexed and low reusable.SDRAM is often used in image preprocessing,and its frequency is very high,so multiple asynchronous FIFO are used for data buffer matching its working frequency.But the control of FIFO is redesigned every time,which is too complicated.The design simpliifes the timing control of the SDRAM,which improves the system`s performance and embeds multi-channel asynchronous FIFO.when faced with a different design needs,the designer just loads the data,clock,depth,and the address on the asynchronous FIFO.It saves logic resources and achieves the purpose of reuse which saves time for the subsequent design.%针对SDRAM控制器设计复杂且可复用性低的特点,基于VerilogHDL提出了一种简单且可灵活定制异步FIFO的SDRAM控制器实现。图像预处理时经常会用到SDRAM来作为缓存,SDRAM的工作频率很高,所以一般会用异步FIFO缓存数据匹配它的频率,但是每次都重新设计FIFO的控制显然太繁琐。本设计结合FPGA的特点一方面简化SDRAM的控制时序提高了系统性能,另一方面在控制器中嵌入多路异步FIFO,当面对不同的设计需要时只需给设计关心的异步FIFO加载上数据、时钟、深度以及地址则可。既节约了逻辑资源又实现了重复使用的目的为后续设计节省了时间。

  15. Customer-to-customer roles and impacts in service encounters

    OpenAIRE

    Lee, Linda

    2016-01-01

    This thesis investigates customer-to-customer roles and impacts in the context of service encounters. This topic is studied from two angles: customer interactions during group service encounters and customer perceptions post service encounters. The first angle is a focus on group service encounters that addresses the lack of research on customer-to-customer interactions that occur in customer-to-customer interaction-intensive contexts. These are contexts where the interactions between custome...

  16. Customer-to-customer roles and impacts in service encounters

    OpenAIRE

    Lee, Linda

    2016-01-01

    This thesis investigates customer-to-customer roles and impacts in the context of service encounters. This topic is studied from two angles: customer interactions during group service encounters and customer perceptions post service encounters. The first angle is a focus on group service encounters that addresses the lack of research on customer-to-customer interactions that occur in customer-to-customer interaction-intensive contexts. These are contexts where the interactions between custome...

  17. Vulnerable Plaques, Inflammation and Newer Imaging Modalities

    Directory of Open Access Journals (Sweden)

    Bhatia V

    2003-01-01

    Full Text Available Currently, inflammation is considered to be the central player in the pathogenesis of atherosclerosis. It leads to the formation of multiple plaques in the arterial beds including coronary vasculature. Recent studies using the latest imaging techniques have shown that in patients with acute coronary syndromes (ACS multiple plaques are ruptured and have thrombus formation on them. Various factors make these plaques unstable, these include structural components of plaque like thin fibrous cap, high lipid content of the plaque core and inflammation, both localized and generalized. It has been shown that most of the ACS are caused by plaques causing non-critical stenosis as seen on traditional X-ray angiography. Also, the phenomenon of remodelling makes angiography a poor technique for plaque visualization. Hence newer modalities are required to identify these 'vulnerable plaques'. Intravascular ultrasound (IVUS, thermography and Magnetic Resonance Imaging (MRI are a few such promising techniques. Here we review the invasive and non-invasive modalities that can be helpful in the identification of these plaques before they become unstable and cause ACS, and also the available therapies to stabilize these plaques.

  18. Automated design of customized implants

    Directory of Open Access Journals (Sweden)

    Vicente Chulvi

    2013-01-01

    Full Text Available Este artículo muestra un modelo que se postula como capaz para el diseño de un implante craneal personalizado directamente desde el proceso de toma de imágenes médica. La salida de este proceso de diseño se conseguirá en un formato capaz de ser reconocido por el sistema de manufactura. El sistema propuesto se ha creado a partir de la unión de dos prototipos informáticos desarrollados durante la presente investigación, y a través del estudio de las tecnologías relacionadas o circundantes. El núcleo del modelo en la tecnología basada en el conocimiento (KBS, que debe permitir de almacenar y gestionar datos médicos y de diseño para poder aplicar dichos conocimientos durante el proceso de diseño del implante. El objeto de este proyecto es el de obtener una herramienta para mejorar el proceso de diseño, la biocompatibilidad con el paciente y reducir los costes finales, y que pueda ser operado sin necesidad del conocimiento completo de todas sus fases por el usuario.

  19. the customer at the final frontier of mass customization

    DEFF Research Database (Denmark)

    Svensson, Carsten; Jensen, Thomas

    2002-01-01

    , some of the factors influencing the use of this business paradigm are discussed and it is argued that the customer is the major limiting factor at the final frontier of mass customisation. Until recently mass customisation have mainly been turned towards the structural design of products, whereas...... this paper argues that there might be a need for an increased focus on the fulfilment of customer needs. As a result of this manufactures will have to hone the balance of trade-offs, as the paradigm of mass customisation becomes a commodity....

  20. The Customer at the Final Frontier of Mass Customization

    DEFF Research Database (Denmark)

    Svensson, Carsten

    2001-01-01

    , some of the factors influencing the use of this business paradigm are discussed and it is argued that the customer is the major limiting factor at the final frontier of mass customisation. Until recently mass customisation have mainly been turned towards the structural design of products, whereas...... this paper argues that there might be a need for an increased focus on the fulfilment of customer needs. As a result of this manufactures will have to hone the balance of trade-offs, as the paradigm of mass customisation becomes a commodity....

  1. The Customer at the Final Frontier of Mass Customization

    DEFF Research Database (Denmark)

    Svensson, Carsten

    2001-01-01

    , some of the factors influencing the use of this business paradigm are discussed and it is argued that the customer is the major limiting factor at the final frontier of mass customisation. Until recently mass customisation have mainly been turned towards the structural design of products, whereas...... this paper argues that there might be a need for an increased focus on the fulfilment of customer needs. As a result of this manufactures will have to hone the balance of trade-offs, as the paradigm of mass customisation becomes a commodity....

  2. Optical design of a novel instrument that uses the Hartmann-Shack sensor and Zernike polynomials to measure and simulate customized refraction correction surgery outcomes and patient satisfaction

    Science.gov (United States)

    Yasuoka, Fatima M. M.; Matos, Luciana; Cremasco, Antonio; Numajiri, Mirian; Marcato, Rafael; Oliveira, Otavio G.; Sabino, Luis G.; Castro N., Jarbas C.; Bagnato, Vanderlei S.; Carvalho, Luis A. V.

    2016-03-01

    An optical system that conjugates the patient's pupil to the plane of a Hartmann-Shack (HS) wavefront sensor has been simulated using optical design software. And an optical bench prototype is mounted using mechanical eye device, beam splitter, illumination system, lenses, mirrors, mirrored prism, movable mirror, wavefront sensor and camera CCD. The mechanical eye device is used to simulate aberrations of the eye. From this device the rays are emitted and travelled by the beam splitter to the optical system. Some rays fall on the camera CCD and others pass in the optical system and finally reach the sensor. The eye models based on typical in vivo eye aberrations is constructed using the optical design software Zemax. The computer-aided outcomes of each HS images for each case are acquired, and these images are processed using customized techniques. The simulated and real images for low order aberrations are compared using centroid coordinates to assure that the optical system is constructed precisely in order to match the simulated system. Afterwards a simulated version of retinal images is constructed to show how these typical eyes would perceive an optotype positioned 20 ft away. Certain personalized corrections are allowed by eye doctors based on different Zernike polynomial values and the optical images are rendered to the new parameters. Optical images of how that eye would see with or without corrections of certain aberrations are generated in order to allow which aberrations can be corrected and in which degree. The patient can then "personalize" the correction to their own satisfaction. This new approach to wavefront sensing is a promising change in paradigm towards the betterment of the patient-physician relationship.

  3. Customers' evaluation of service

    Directory of Open Access Journals (Sweden)

    J. Tsosa

    2002-12-01

    Full Text Available The analysis on the aspect chosen will provide an understanding and expand more on the strategic thinking that impact on corporate image on quality, customer satisfaction and loyalty for customers with varying degrees of service expertise.

  4. Managing Customer Expectations

    National Research Council Canada - National Science Library

    Jeff Parke

    2012-01-01

      If a service provider customer's satisfaction level is changing, find out if something has happened, either at the customer's end or at the service provider's, to affect their expectations or perceptions...

  5. Discussion on the Integrated Supporting and Requirements Designing of Group Customers Business%集团客户业务一体化支撑需求设计探讨

    Institute of Scientific and Technical Information of China (English)

    刘小发; 李良; 黄强华; 吕美嫦

    2014-01-01

    随着移动通信网络的不断升级和移动互联网业务的不断发展壮大,集团客户业务越来越成为运营商发展的重要战略市场。基于集团客户业务的发展现状、产品体系、系统支撑现状情况,从集团客户业务的基本特点出发,对集团客户业务的产品形态进行研究分析,针对集团客户业务个性化需求的特点,从客户、产品、业务等表现形式进行详细分析,对运营商集团客户业务需求支撑、产品设计、业务发展等进行研究探讨,提出一体化支撑需求设计。%With the development of mobile communication network and expansion of mobile Internet business, group customers busi-ness is increasingly becoming an important strategic market of the operators. Based on the current development of group cus-tomers business, products system, the present situation of system supporting, it researches and analyzes the production form from the basic characteristics of group customers business. It analyzes the display of customer, production, service and so on from the personalized needs of group customers business. It researches and discusses the demand supporting, production de-signing and business development of group customers business and proposes the integrated supporting and requirements de-signing.

  6. Customer Experience Management Overview

    OpenAIRE

    Havíř, David

    2016-01-01

    Purpose of the article: The purpose of this paper is to examine the phenomenon of customer experience and customer experience management through years and summarize recent knowledge in this area. Methodology/methods: The paper is built upon secondary research of research papers of renowned authors in the area of customer experience management. Scientific aim: The aim of the article is to find out potential avenues of further research. Findings: Findings confirmed that customer experience is s...

  7. Understanding customer experience.

    Science.gov (United States)

    Meyer, Christopher; Schwager, Andre

    2007-02-01

    Anyone who has signed up for cell phone service, attempted to claim a rebate, or navigated a call center has probably suffered from a company's apparent indifference to what should be its first concern: the customer experiences that culminate in either satisfaction or disappointment and defection. Customer experience is the subjective response customers have to direct or indirect contact with a company. It encompasses every aspect of an offering: customer care, advertising, packaging, features, ease of use, reliability. Customer experience is shaped by customers' expectations, which largely reflect previous experiences. Few CEOs would argue against the significance of customer experience or against measuring and analyzing it. But many don't appreciate how those activities differ from CRM or just how illuminating the data can be. For instance, the majority of the companies in a recent survey believed they have been providing "superior" experiences to customers, but most customers disagreed. The authors describe a customer experience management (CEM) process that involves three kinds of monitoring: past patterns (evaluating completed transactions), present patterns (tracking current relationships), and potential patterns (conducting inquiries in the hope of unveiling future opportunities). Data are collected at or about touch points through such methods as surveys, interviews, focus groups, and online forums. Companies need to involve every function in the effort, not just a single customer-facing group. The authors go on to illustrate how a cross-functional CEM system is created. With such a system, companies can discover which customers are prospects for growth and which require immediate intervention.

  8. Customer loyalty building

    OpenAIRE

    Nováková, Veronika

    2012-01-01

    This bachelor thesis focuses on the customer loyalty. It gives an example of CRM project which aims to build the loyalty of customers to some brand or product so the customer would return to the company and would be satisfied with all products and services he get.

  9. Atherosclerotic plaque regression: fact or fiction?

    Science.gov (United States)

    Shanmugam, Nesan; Román-Rego, Ana; Ong, Peter; Kaski, Juan Carlos

    2010-08-01

    Coronary artery disease is the major cause of death in the western world. The formation and rapid progression of atheromatous plaques can lead to serious cardiovascular events in patients with atherosclerosis. The better understanding, in recent years, of the mechanisms leading to atheromatous plaque growth and disruption and the availability of powerful HMG CoA-reductase inhibitors (statins) has permitted the consideration of plaque regression as a realistic therapeutic goal. This article reviews the existing evidence underpinning current therapeutic strategies aimed at achieving atherosclerotic plaque regression. In this review we also discuss imaging modalities for the assessment of plaque regression, predictors of regression and whether plaque regression is associated with a survival benefit.

  10. THE ROLE OF CUSTOMER SATISFACTION IN MEDIATING MARKETING COMMUNICATION EFFECT ON CUSTOMER LOYALTY

    Directory of Open Access Journals (Sweden)

    Mohamad Dimyati,

    2015-11-01

    Full Text Available This study aims to test the effect of a marketing communication on customer satisfaction; b marketing communication on customer loyalty; c customer satisfaction on customer loyalty; and d to identify the role of customer satisfaction in mediating marketing communication effect on customer loyalty of the IM3 user community in Jember regency, East Java province. The study was designed in a form confirmatory research, with the whole IM3 community members in the regency as the study population. By using random sampling, 100 respondents were taken as the samples. Structural Equation Modeling (SEM was applied as the data analysis model. The result shows that: a marketing communication has a significantly positive effect on customer satisfaction; b marketing communication has a significantly positive effect on customer loyalty; c customer satisfaction has a significantly positive effect on customer loyalty; and d customer satisfaction has a very important role in mediating marketing communication effect on customer loyalty of the IM3 user community in Jember regency

  11. Customers as Partners in Radical Service Innovation

    DEFF Research Database (Denmark)

    Scupola, Ada; Nicolajsen, Hanne Westh

    2009-01-01

      Purpose- The main purpose of this paper is to investigate customer involvement and related challenges in radical service innovations in engineering consulting services Design/methodology/approach - The paper uses a case study approach and so called rich descriptions to investigate customer invo...

  12. Clinical evaluation of a novel herbal dental cream in plaque formation: a double-blind, randomized, controlled clinical trial

    OpenAIRE

    amrutesh, sunita; Malini, J; Tandur, Prakash S; Pralhad S. Patki

    2010-01-01

    Background The aim of this study was to evaluate the efficacy and safety of herbal dental cream in comparison to fluoride dental cream. Objectives Clinical evaluation of a novel herbal dental cream in plaque formation: a double-blind, randomized, controlled clinical trial. Methods One hundred and two patients with established dental plaque were randomly assigned to either herbal dental group or fluoride dental group for six weeks in a double-blind design. Improvement in plaque index, oral hyg...

  13. Influence of custom-made implant designs on the biomechanical performance for the case of immediate post-extraction placement in the maxillary esthetic zone: a finite element analysis.

    Science.gov (United States)

    Chen, Jianyu; Zhang, Zhiguang; Chen, Xianshuai; Zhang, Xiao

    2017-01-29

    Due to the increasing adoption of immediate implantation strategies and the rapid development of the computer aided design/computer aided manufacturing technology, a therapeutic concept based on patient-specific implant dentistry has recently been reintroduced by many researchers. However, little information is available on the designs of custom-made dental implant systems, especially their biomechanical behavior. The influence of the custom-made implant designs on the biomechanical performance for both an immediate and a delayed loading protocol in the maxillary esthetic zone was evaluated by means of the finite element (FE) method. FE models of three dental implants were considered: a state of the art cylindrical implant and two custom-made implants designed by reverse engineering technology, namely a root-analogue implant and a root-analogue threaded implant. The von Mises stress distributions and micro-motions around the bone-implant interfaces were calculated using ANSYS software. In a comparison of the three implant designs for both loading protocols, a favorable biomechanical performance was observed for the use of root-analogue threaded implant which approximated the geometry of natural anterior tooth and maintained the original long-axis. The results indicated that bone-implant interfacial micro-motion was reduced and a favorable stress distribution after osseointegration was achieved.

  14. Accuracy of coronary plaque detection and assessment of interobserver agreement for plaque quantification using automatic coronary plaque analysis software on coronary CT angiography

    Energy Technology Data Exchange (ETDEWEB)

    Laqmani, A.; Quitzke, M.; Creder, D.D.; Adam, G.; Lund, G. [University Medical Center Hamburg-Eppendorf, Hamburg (Germany). Dept. of Diagnostic and Interventional Radiology and Nuclearmedicine; Klink, T. [Wuerzburg Univ. (Germany). Inst. of Diagnostic and Interventional Radiology

    2016-10-15

    To evaluate the accuracy of automatic plaque detection and the interobserver agreement of automatic versus manually adjusted quantification of coronary plaques on coronary CT angiography (cCTA) using commercially available software. 10 cCTA datasets were evaluated using plaque software. First, the automatically detected plaques were verified. Second, two observers independently performed plaque quantification without revising the automatically constructed plaque contours (automatic approach). Then, each observer adjusted the plaque contours according to plaque delineation (adjusted approach). The interobserver agreement of both approaches was analyzed. 32 of 114 automatically identified findings were true-positive plaques, while 82 (72 %) were false-positive. 20 of 52 plaques (38 %) were missed by the software (false-negative). The automatic approach provided good interobserver agreement with relative differences of 0.9 ± 16.0 % for plaque area and -3.3 ± 33.8 % for plaque volume. Both observers independently adjusted all contours because they did not represent the plaque delineation. Interobserver agreement decreased for the adjusted approach with relative differences of 25.0 ± 24.8 % for plaque area and 20.0 ± 40.4 % for plaque volume. The automatic plaque analysis software is of limited value due to high numbers of false-positive and false-negative plaque findings. The automatic approach was reproducible but it necessitated adjustment of all constructed plaque contours resulting in deterioration of the interobserver agreement.

  15. Linking Customer Interaction and Innovation

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Laursen, Keld; Pedersen, Torben

    2011-01-01

    The notion that firms can improve their innovativeness by tapping users and customers for knowledge has become prominent in innovation studies. Similar arguments have been made in the marketing literature. We argue that neither literatures take sufficient account of firm organization. Specifically......, firms that attempt to leverage user and customer knowledge in the context of innovation must design an internal organization appropriate to support it. This can be achieved in particular through the use of new organizational practices, notably, intensive vertical and lateral communication, rewarding...... employees for sharing and acquiring knowledge, and high levels of delegation of decision rights. In this paper, six hypotheses were developed and tested on a data set of 169 Danish firms drawn from a 2001 survey of the 1,000 largest firms in Denmark. A key result is that the link from customer knowledge...

  16. 关于客户关系管理系统的初步设计%Preliminary Design of Customer Relationship Management System

    Institute of Scientific and Technical Information of China (English)

    高瑞

    2012-01-01

    介绍了系统的开发背景以及课题意义,并对系统进行了详细的可行性分析(包括对软件的开发工具SQL Server和ASP.NET工作原理的详细介绍).按照软件的开发步骤,从管理系统的需求分析到总体设计到详细设计阐述了系统的功能实现过程.本企业管理系统是根据现这种现状设计的一个面向中小型企业的简单任务管理系统,主要实现对公司职员的任务管理.客户关系管理系统(CRM)是典型的管理信息系统,其主要开发包括后台数据库的建立和维护以及前端应用程序的开发两个方面.目前国内类似管理平台还尚不成熟,因此本项研究具有一定的创新性和实践意义.%This paper introduced the development background and subject system significance of the system, and made a detailed feasibility analysis on the system (including the detailed introduction of software's development tool SQL Server and ASP.NET work principle), and then expounded the realization process of function of the system, starting from its requirements analysis to the overall design to detailed design, according to the software's development steps. The enterprise management system is a simple task management system designed by facing with SMEs according to the current situation, which mainly realizes the task management of company staff. Customer Relationship Management (CRM) system is the typical information management system, and its main development includes the setting and maintenance of background database as well as development of front-end application. At present, domestic similar management platform is still immature, therefore, this study has innovativeness and practical significance.

  17. Conservative and esthetic cast gold fixed partial dentures-inlay, onlay, and partial veneer retainers, custom composite pontics, and stress-breakers: part I: fundamental design principles.

    Science.gov (United States)

    Stevenson, Richard G; Refela, Jane A

    2009-01-01

    Although in today's dental world implant restorations are considered the standard of care in the replacement of missing teeth, clinical contraindications and patient nonacceptance of implant placement can be encountered. Several scenarios are discussed here in which a single missing tooth can be restored with conservative fixed partial dentures (FPD) that employ cast gold retainers; each with a customized design in order to preserve tooth structure, maintain esthetics, and provide a long-term prognosis. The abutment teeth are prepared for conservative partial coverage restorations by using Brasseler burs (Brasseler USA, Savannah, GA, USA). Impressions are taken of the preparations, along with any retentive features, utilizing either the Vented Pin Channel technique or the Shooshan Plastic Pin technique. The latter technique utilizes Kodex twist drills and corresponding impression pins (Coltene Whaledent Inc., Mahwah, NJ, USA). The conservative FPD with non-rigid connectors is fabricated by using type III gold alloy. The pontic cage portion is chemically prepared utilizing the Panavia F2.0 cement kit (Kuraray America Inc., Houston, TX, USA) or other dual-polymerizing resin cement and restored with any type of direct composite resin material. A palette of opaquers and tints are used for chairside characterization of the esthetic pontic facing. The final polish of the pontic is completed by using FlexiDisc and FlexiBuff discs (Cosmedent Inc., Chicago, IL, USA). CLINICAL SIGNIFICANCE In cases where an implant restoration is contraindicated for replacement of a single tooth, a semi-precision FPD is a conservative, functional, and esthetic alternative.

  18. 高校教师个人主页定制系统设计%Design of a university teacher profile customization system

    Institute of Scientific and Technical Information of China (English)

    金博闻; 徐峰; 吴暾华

    2013-01-01

    非计算机专业的高校教师缺乏动态网页编程知识,无法自行设计复杂的个人主页。因此,建立一个面向高校教师的、可定制内容的、具有傻瓜化操作界面的个人主页系统具有非常重要的现实意义。本研究建立了一个面向各专业教师的个人主页定制系统。实践结果表明,通过本系统教师可快速建立起自己的个人主页,展示自己的科研成果并与学生进行互动交流,增进了师生之间、同行之间的沟通与合作。%As non-computer-professional university teachers lack the knowledge of dynamic web programming , they are inca-pable to design complex profile . Therefore , the establishment of a customizable university teachers oriented profile system which having convenient operations has very important practical significance . In this study , a profile customization system for various pro-fessional teachers was established . The results show that teachers can rapidly setup their own personal home pages , display their re-search results and interact with students by this system . And this system can enhance the communication with students as well as the cooperation with peers .

  19. Is Mass Customization Sustainable?

    DEFF Research Database (Denmark)

    Petersen, Thomas Ditlev; Jørgensen, Kaj Asbjørn; Nielsen, Kjeld

    2011-01-01

    Mass customizers are like other companies currently experiencing an increasing customer demand for environmentally sustainable products as well as an increasingly strict legislation regarding environmental sustainability. This paper addresses the issue whether the concepts mass customization...... and sustainability are fundamentally compatible by asking the question: can a mass customized product be sustainable? Several factors could indicate that mass customized products are less sustainable than standardized products; however other factors suggest the opposite. This paper explores these factors during...... three life cycle phases for a product: Production, Use and End of Life. It is concluded that there is not an unambiguous causal relationship between mass customization and sustainability; however several factors unique to mass customized products are essential to consider during product and process...

  20. Companies and the customers who hate them.

    Science.gov (United States)

    McGovern, Gail; Moon, Youngme

    2007-06-01

    Why do companies bind customers with contracts, bleed them with fees, and baffle them with fine print? Because bewildered customers, who often make bad purchasing decisions, can be highly profitable. Most firms that profit from customers' confusion are on a slippery slope. Over time, their customer-centric strategies for delivering value have evolved into company-centric strategies for extracting it. Not surprisingly, when a rival comes along with a friendlier alternative, customers defect. Adversarial value-extracting strategies are common in such industries as cell phone service, retail banking, and health clubs. Overly complex product and pricing options, for example, may have been designed to serve various segments. But in fact they take advantage of how difficult it is for customers to predict their needs (such as how many cell phone minutes they'll use each month) and make it hard for them to choose the right product. Similarly, penalties and fees, which may have been instituted to offset the costs of undesirable customer behavior, like bouncing checks, turn out to be very profitable. As a result, companies have no incentive to help customers avoid them. Tactics like these generate bad publicity and fuel customer defections, creating opportunities for competitors. Virgin Mobile USA, for example, has lured millions of angry cell phone customers away from the incumbents by offering a straightforward plan with no hidden fees, no time-of-day restrictions, and no contracts. ING Direct, now the fourth-largest thrift bank in the United States, offers accounts with no fees, no tiered interest rates, and no minimums. In industries where squeezing value from customers is commonplace, companies that dismantle these harmful practices and design a transparent, value-creating offer can head off customer retaliation and spur rapid growth.

  1. Mechanical Stresses in Carotid Plaques

    DEFF Research Database (Denmark)

    Samuel, Samuel Alberg

    Aterosklerose er den hyppigste årsag til død og svær invaliditet i verden. Sygdommen danner aterosklerotiske plaques, som består af lipidkerner dækket af en fibrøs kappe. Såfremt kappen brister, dannes overliggende tromber, som kan føres med blodstrømmen og forårsage strokes hvis kappen brister i...... mekaniske kræfter, som påvirker den fibrøse kappe, for at være en medvirkende årsag til plaqueruptur. Endvidere er stress-niveauerne i den fibrøse kappe en risikomarkør, som påvirkes af såvel den fibrøse kappetykkelse som lipid kerne størrelsen, blodtryk og graden af forsnævring. Imidlertid har hidtidige...... for at få fjernet deres plaques (carotis endarterektomi). Dernæst blev skanningerne segmenteret i lipid-kerne, fibrøs kappe, blodbane, karvæg og calcificationer. Endvidere blev blodets hastighed, blodtryk og karvægs deformationer målt. Disse data blev benyttet til longitudinelle fluid-struktur interaktions...

  2. Comparative Plaque Removal Efficacy of Three Manual Toothbrushes.

    Science.gov (United States)

    Ghassemi, A; Vorwerk, L; Hooper, W; Kwang, M; Naji, M; Goyal, C R; Qaqish, J

    2016-09-01

    The purpose of this study was to determine the safety and plaque-reducing effectiveness of a newly designed manual toothbrush compared to that of a leading marketed toothbrush and a reference standard manual toothbrush control. This examiner-blind, randomized, single-use study used a cross-over design. Sixty-eight qualifying male and female subjects were randomly assigned either an Arm & Hammer™ Truly Radiant™ Deep Clean manual toothbrush (TR), a Colgate® Extra Clean manual toothbrush (C), or an ADA reference standard manual toothbrush (SM) according to one of three computer-generated sequences. Following instruction in the use of their assigned brush, subjects brushed at home with a standard fluoride toothpaste twice daily for two minutes during a one-week familiarization period. At the end of this period, the subjects returned to the study site after refraining from oral hygiene for 12-16 hours and from eating and drinking for four hours. Plaque was disclosed and scored using the Rustogi Modification of the Navy Plaque Index (RMNPI). Subjects brushed under supervision with their assigned toothbrush for two minutes in a room without mirrors and apart from the dental examiner, after which plaque was disclosed and rescored. They were then given one of the alternate toothbrushes according to their assigned sequence, and the familiarization routine and evaluations were repeated until each of the subjects used each of the three brushes. Within-treatment and between-treatment whole mouth RMNPI scores and scores at each of twelve subsets of sites were analyzed using paired t-tests and appropriate ANCOVA models, respectively. Within-group analyses showed that all three toothbrushes produced statistically significant reductions from the pre-brushing baseline in whole mouth RMNPI scores (p < 0.0001), with respective reductions of 68.2%, 58.3%, and 48.5% for TR, C, and SM. Between-group analyses showed that TR was significantly more effective (p < 0.0001) than C and SM

  3. Current status of vulnerable plaque detection.

    LENUS (Irish Health Repository)

    Sharif, Faisal

    2012-02-01

    Critical coronary stenoses have been shown to contribute to only a minority of acute coronary syndromes (ACS) and sudden cardiac death. Autopsy studies have identified a subgroup of high-risk patients with disrupted vulnerable plaque and modest stenosis. Consequently, a clinical need exists to develop methods to identify these plaques prospectively before disruption and clinical expression of disease. Recent advances in invasive and noninvasive imaging techniques have shown the potential to identify these high-risk plaques. The anatomical characteristics of the vulnerable plaque such as thin cap fibroatheroma and lipid pool can be identified with angioscopy, high frequency intravascular ultrasound, intravascular MRI, and optical coherence tomography. Efforts have also been made to recognize active inflammation in high-risk plaques using intravascular thermography. Plaque chemical composition by measuring electromagnetic radiation using spectroscopy is also an emerging technology to detect vulnerable plaques. Noninvasive imaging with MRI, CT, and PET also holds the potential to differentiate between low and high-risk plaques. However, at present none of these imaging modalities are able to detect vulnerable plaque neither has been shown to definitively predict outcome. Nevertheless in contrast, there has been a parallel development in the physiological assessment of advanced atherosclerotic coronary artery disease. Thus recent trials using fractional flow reserve in patients with modest non flow-limiting stenoses have shown that deferral of PCI with optimal medical therapy in these patients is superior to coronary intervention. Further trials are needed to provide more information regarding the natural history of high-risk but non flow-limiting plaque to establish patient-specific targeted therapy and to refine plaque stabilizing strategies in the future.

  4. A bio-inspired approach for the design of a multifunctional robotic end-effector customized for automated maintenance of a reconfigurable vibrating screen.

    Science.gov (United States)

    Makinde, O A; Mpofu, K; Vrabic, R; Ramatsetse, B I

    2017-01-01

    The development of a robotic-driven maintenance solution capable of automatically maintaining reconfigurable vibrating screen (RVS) machine when utilized in dangerous and hazardous underground mining environment has called for the design of a multifunctional robotic end-effector capable of carrying out all the maintenance tasks on the RVS machine. In view of this, the paper presents a bio-inspired approach which unfolds the design of a novel multifunctional robotic end-effector embedded with mechanical and control mechanisms capable of automatically maintaining the RVS machine. To achieve this, therblig and morphological methodologies (which classifies the motions as well as the actions required by the robotic end-effector in carrying out RVS machine maintenance tasks), obtained from a detailed analogy of how human being (i.e. a machine maintenance manager) will carry out different maintenance tasks on the RVS machine, were used to obtain the maintenance objective functions or goals of the multifunctional robotic end-effector as well as the maintenance activity constraints of the RVS machine that must be adhered to by the multifunctional robotic end-effector during the machine maintenance. The results of the therblig and morphological analyses of five (5) different maintenance tasks capture and classify one hundred and thirty-four (134) repetitive motions and fifty-four (54) functions required in automating the maintenance tasks of the RVS machine. Based on these findings, a worm-gear mechanism embedded with fingers extruded with a hexagonal shaped heads capable of carrying out the "gripping and ungrasping" and "loosening and bolting" functions of the robotic end-effector and an electric cylinder actuator module capable of carrying out "unpinning and hammering" functions of the robotic end-effector were integrated together to produce the customized multifunctional robotic end-effector capable of automatically maintaining the RVS machine. The axial forces ([Formula

  5. Development & Implementation of Baby Cart Rapid Design Platform Based on Customer Demand-driven%以客户需求为驱动的婴儿推车快速设计平台的开发与实现

    Institute of Scientific and Technical Information of China (English)

    王枫红; 陈炽坤; 王永根

    2012-01-01

    The research and development of baby cart rapid design platform based on customer demand-driven were carried according to rapid design ideas. The characteristics of the design platform based on customer demand, main interface design, implementation of customer demand and rapid design based on configuration design and variant design were discussed. In order to select the high matching degree product model in the database, at the same time with good assembly fit among different product module and to achieve configuration design and variant design effectively, retrieval assembly algorithm about sub assembly was provided and discussed.%以快速设计思想为指导,对以实现客户需求为驱动的婴儿推车快速设计平台展开了系统性研究与开发.论述了以客户需求为驱动的设计平台特性、快速设计平台的主界面设计、客户产品需求定制的实现和基于配置与变型方法的快速设计的实现.为了选取产品实例库中与客户需求匹配程度高、产品族各模块间的装配契合度好的模型,高效实现配置设计和变型设计,提出多子装配体的检索装配算法.

  6. Increased expression of fatty acid binding protein 4 and leptin in resident macrophages characterises atherosclerotic plaque rupture

    Science.gov (United States)

    Lee, K.; Santibanez-Koref, M.; Polvikoski, T.; Birchall, D.; Mendelow, A.D.; Keavney, B.

    2013-01-01

    Objective Resident macrophages play an important role in atheromatous plaque rupture. The macrophage gene expression signature associated with plaque rupture is incompletely defined due to the complex cellular heterogeneity in the plaque. We aimed to characterise differential gene expression in resident plaque macrophages from ruptured and stable human atheromatous lesions. Methods and results We performed genome-wide expression analyses of isolated macrophage-rich regions of stable and ruptured human atherosclerotic plaques. Plaques present in carotid endarterectomy specimens were designated as stable or ruptured using clinical, radiological and histopathological criteria. Macrophage-rich regions were excised from 5 ruptured and 6 stable plaques by laser micro-dissection. Transcriptional profiling was performed using Affymetrix microarrays. The profiles were characteristic of activated macrophages. At a false discovery rate of 10%, 914 genes were differentially expressed between stable and ruptured plaques. The findings were confirmed in fourteen further stable and ruptured samples for a subset of eleven genes with the highest expression differences (p < 0.05). Pathway analysis revealed that components of the PPAR/Adipocytokine signaling pathway were the most significantly upregulated in ruptured compared to stable plaques (p = 5.4 × 10−7). Two key components of the pathway, fatty-acid binding-protein 4 (FABP4) and leptin, showed nine-fold (p = 0.0086) and five-fold (p = 0.0012) greater expression respectively in macrophages from ruptured plaques. Conclusions We found differences in gene expression signatures between macrophages isolated from stable and ruptured human atheromatous plaques. Our findings indicate the involvement of FABP4 and leptin in the progression of atherosclerosis and plaque rupture, and suggest that down-regulation of PPAR/adipocytokine signaling within plaques may have therapeutic potential. PMID:23122912

  7. Biomechanics and inflammation in atherosclerotic plaque erosion and plaque rupture: implications for cardiovascular events in women.

    Directory of Open Access Journals (Sweden)

    Ian C Campbell

    Full Text Available Although plaque erosion causes approximately 40% of all coronary thrombi and disproportionally affects women more than men, its mechanism is not well understood. The role of tissue mechanics in plaque rupture and regulation of mechanosensitive inflammatory proteins is well established, but their role in plaque erosion is unknown. Given obvious differences in morphology between plaque erosion and rupture, we hypothesized that inflammation in general as well as the association between local mechanical strain and inflammation known to exist in plaque rupture may not occur in plaque erosion. Therefore, our objective was to determine if similar mechanisms underlie plaque rupture and plaque erosion.We studied a total of 74 human coronary plaque specimens obtained at autopsy. Using lesion-specific computer modeling of solid mechanics, we calculated the stress and strain distribution for each plaque and determined if there were any relationships with markers of inflammation. Consistent with previous studies, inflammatory markers were positively associated with increasing strain in specimens with rupture and thin-cap fibroatheromas. Conversely, overall staining for inflammatory markers and apoptosis were significantly lower in erosion, and there was no relationship with mechanical strain. Samples with plaque erosion most closely resembled those with the stable phenotype of thick-cap fibroatheromas.In contrast to classic plaque rupture, plaque erosion was not associated with markers of inflammation and mechanical strain. These data suggest that plaque erosion is a distinct pathophysiological process with a different etiology and therefore raises the possibility that a different therapeutic approach may be required to prevent plaque erosion.

  8. The unstable plaque: a diagnostic challenge in cardiology; Diagnostische Herausforderung in der Kardiologie: Die instabile arteriosklerotische Plaque

    Energy Technology Data Exchange (ETDEWEB)

    Levkau, B. [Inst. fuer Pathophysiologie, Universitaetsklinikum Essen (Germany); Schaefers, M. [Klinik und Poliklinik fuer Nuklearmedizin, Universitaetsklinikum Muenster (Germany)

    2004-09-01

    Atherosclerotic plaque rupture still accounts for one third of all deaths worldwide and constitutes a major source of disability and health care costs. Dysregulation of MMPs in the atherosclerotic lesion may result in mechanical destabilization and rupture of the atherosclerotic plaque, potentially leading to thrombosis and vessel occlusion with life-threatening clinical complications. Therefore, identifying individual patients at high risk of plaque rupture is an important challenge in clinical medicine. We have used the broad-spectrum MMP inhibitor CGS 27023A to develop the radioligand [{sup 123}I]I-HO-CGS 27023A for in vivo imaging of MMP activity. Using this radioligand, we were able to specifically image MMP activity by scintigraphy in vivo in the MMP-rich vascular lesions that develop after carotid artery ligation and cholesterol-rich diet in apolipoprotein E-deficient mice. Thus, imaging of MMP activity in vivo is feasible using radiolabelled MMP inhibitors. In combination with the high-resolution morphological imaging techniques such as MRI and CT, the molecular imaging of individual disease parameters such as MMP activity in lesions of atherosclerosis may help design approaches for the prediction and prevention of coronary events due to plaque rupture of an individual lesion in an individual patient. (orig.)

  9. The case for customer loyalty.

    Science.gov (United States)

    Sturm, Arthur C

    2004-09-01

    How does customer loyalty grow? Through good customer experiences. Yet some organizations seem to genuinely fail to understand that they can keep or lose a customer in the proverbial blink of an eye. And in this era of increasing customer demands across all industries, it's important that healthcare financial managers understand the correlation between customer loyalty and customer experience.

  10. Fluoride bioavailability in saliva and plaque

    Science.gov (United States)

    2012-01-01

    Background Different fluoride formulations may have different effects on caries prevention. It was the aim of this clinical study to assess the fluoride content, provided by NaF compared to amine fluoride, in saliva and plaque. Methods Eight trained volunteers brushed their teeth in the morning for 3 minutes with either NaF or amine fluoride, and saliva and 3-day-plaque-regrowth was collected at 5 time intervals during 6 hours after tooth brushing. The amount of collected saliva and plaque was measured, and the fluoride content was analysed using a fluoride sensitive electrode. All subjects repeated all study cycles 5 times, and 3 cycles per subject underwent statistical analysis using the Wilcoxon-Mann-Whitney test. Results Immediately after brushing the fluoride concentration in saliva increased rapidly and dropped to the baseline level after 360 minutes. No difference was found between NaF and amine fluoride. All plaque fluoride levels were elevated after 30 minutes until 120 minutes after tooth brushing, and decreasing after 360 minutes to baseline. According to the highly individual profile of fluoride in saliva and plaque, both levels of bioavailability correlated for the first 30 minutes, and the fluoride content of saliva and plaque was back to baseline after 6 hours. Conclusions Fluoride levels in saliva and plaque are interindividually highly variable. However, no significant difference in bioavailability between NaF and amine fluoride, in saliva, or in plaque was found. PMID:22230722

  11. Oral biofilm models for mechanical plaque removal

    NARCIS (Netherlands)

    Verkaik, Martinus J.; Busscher, Henk J.; Rustema-Abbing, Minie; Slomp, Anje M.; Abbas, Frank; van der Mei, Henny C.

    2010-01-01

    In vitro plaque removal studies require biofilm models that resemble in vivo dental plaque. Here, we compare contact and non-contact removal of single and dual-species biofilms as well as of biofilms grown from human whole saliva in vitro using different biofilm models. Bacteria were adhered to a sa

  12. 基于虚拟与协同的旅游产品定制系统开发%Tourism Souvenirs Customized System Development Based on Virtual and Collaborative Design

    Institute of Scientific and Technical Information of China (English)

    李宁; 余隋怀; 姚澜

    2013-01-01

    With VR, network, digital technology development, consumers can realize the tourism product customization in the construction of virtual environment through Internet. This is a kind of interactive, realistic and real-time customization mode, the users can see their own customized virtual prototype on the computer screen, and ultimately receive it. The enterprise uses Internet to unite the companies, the design resources, intellectual resources and manufacturing resources in different regions, in order to meet the customers' demands for personalized.%随着虚拟现实、网络技术、数字化技术的发展,消费者可以通过Internet在构建的虚拟环境下进行旅游产品个性化定制.这是一种交互的、真实的和实时性的定制方式,用户能在电脑屏幕上看到自己个性化定制的产品虚拟原型,并最终获得实物.企业通过Internet将分布在不同地域和不同单位的设计资源、智力资源和制造资源集成起来协同合作,满足客户的个性化需求.

  13. PLAQUE ASSAY OF NEWCASTLE DISEASE VIRUS

    Directory of Open Access Journals (Sweden)

    B. Sardjono

    2012-09-01

    Full Text Available The Newcastle disease virus (NDV was isolated from a 3 months-old indigenous chicken (buras or kampung chicken which showed clinical signs of Newcastle disease (ND. For viral isolation a small part of the spleen and lung were inoculated into 10 days-old embryonated chicken eggs. The physical characteristics of the isolate (A/120 were studied. The hemagglutination of chicken red blood cell showed slow elution, thermostability of hemagglutinin at 56°C was 120 minutes. The vims was able to agglutinate horse erythrocytes but not those of sheep. The biological characteristics on mean death time (MDT of embryonated chicken egg and plaque morphology on chicken embryo fibroblast (CEF primary cell cultures were studied. The MDT was 56 hours, the isolate was velogenic NDV. There were three different plaque morphologies on CEF : 2 mm clear plaques, 1 mm clear plaques, and minute clear plaques which were visible only with microscopic examination.

  14. How Customers Choose Hotels

    OpenAIRE

    Hera Oktadiana; Andhika Kurnia

    2011-01-01

    In the advancement of hospitality industry, thus it is important for hotel sales and marketing to understand the customer behavior in order to create effective marketing. Factors that influence customer behavior as individuality consist of personal and interpersonal factors. Personal factors include the needs, wants, motivation, perception, learning, personality, lifestyle, and self-concept. Meanwhile, interpersonal factors come from culture and sub-culture, group references, customers throug...

  15. A review of the customer lifetime value as a customer profitability measure in the context of customer relationship management

    Directory of Open Access Journals (Sweden)

    Raphael Damm

    2011-11-01

    Full Text Available Purpose: A number of customer metrics allow estimating customer profitability with methods such as the Customer Lifetime Value (CLV. However, investments in customer relationships carry the potential risk to destroy value and reduce profitability when based on incorrect estimates of customer profitability. Therefore, estimating future customer value correctly is essential to allocate marketing expenditures in the most effective way. In this article recent literature about the CLV is reviewed in order to assess its ability as a customer profitability measure. Besides the financial perspective of the CLV, non-financial perspectives such as customer advocacy, (customer or open innovation and learning have been identified to have an impact on customer profitability. How to properly estimate a customer’s value taking all relevant value creating factors, financial as well as non-financial, into account is the underlying research question.Design/methodology/approach: This research is based on the review of a number of theoretical and empirical articles published between 1990 and 2010. The aggregation of measures, key-drivers and risks of each key-perspective of the customer relationship contributes to the development of a more systematic understanding of the value creation process and provides answers to the research question. Indirect effects of the CLV as a source of value have received increasing attention in previous research but are not sufficiently accounted for by mainstream methods for valuing customers (Ryals, 2008. Therefore, the attempt to structure available knowledge on indirect effects of the CLV in its contextual setting is made.Findings: This research is concluded providing evidence that one-dimensional calculations of the CLV deliver an incomplete picture of the customer relationship and estimate customer profitability incorrectly. This supports the idea of a multidimensional CLV approach that accounts for interrelated key

  16. Determining customer satisfaction in anatomic pathology.

    Science.gov (United States)

    Zarbo, Richard J

    2006-05-01

    Measurement of physicians' and patients' satisfaction with laboratory services has become a standard practice in the United States, prompted by national accreditation requirements. Unlike other surveys of hospital-, outpatient care-, or physician-related activities, no ongoing, comprehensive customer satisfaction survey of anatomic pathology services is available for subscription that would allow continual benchmarking against peer laboratories. Pathologists, therefore, must often design their own local assessment tools to determine physician satisfaction in anatomic pathology. To describe satisfaction survey design that would elicit specific information from physician customers about key elements of anatomic pathology services. The author shares his experience in biannually assessing customer satisfaction in anatomic pathology with survey tools designed at the Henry Ford Hospital, Detroit, Mich. Benchmarks for physician satisfaction, opportunities for improvement, and characteristics that correlated with a high level of physician satisfaction were identified nationally from a standardized survey tool used by 94 laboratories in the 2001 College of American Pathologists Q-Probes quality improvement program. In general, physicians are most satisfied with professional diagnostic services and least satisfied with pathology services related to poor communication. A well-designed and conducted customer satisfaction survey is an opportunity for pathologists to periodically educate physician customers about services offered, manage unrealistic expectations, and understand the evolving needs of the physician customer. Armed with current information from physician customers, the pathologist is better able to strategically plan for resources that facilitate performance improvements in anatomic pathology laboratory services that align with evolving clinical needs in health care delivery.

  17. Customer relationships marketing

    OpenAIRE

    Đorđević Bojan

    2005-01-01

    Market economy terms impose on modern companies the need to change their business relationships to customers. In this way has the term "customer relationship marketing", known as CRM, come into use. Customers are the most valuable asset of a company, and the wisdom and essence of CRM can be presented in two words - profitable and long-term. Modern customer is an individual. They are smart, informed, have great expectations and want only the best, and they can change their supplier by one clic...

  18. 基于Web3D的灯饰协同设计定制系统%A collaborative design system for customized lighting based on Web3D

    Institute of Scientific and Technical Information of China (English)

    冯开平; 潘光洋

    2012-01-01

    The shortcoming of traditional design process of lighting is analyzed, and a practicable plan of collaborative design between customer and designer is presented. Crucial technology in the collaborative design of lighting based on Web3D is particularly described which includes how to achieve interaction, synchronization and mutual repellence in lighting design. And it developed an online design system based on web3d technology in which the customers play the host role while the designers play the consultant role. The system has been validated by experiment.%论文分析了目前传统的灯饰设计所存在的不足,提出了客户与设计师协同设计的可行方案,详细介绍了基于Web3D的灯饰协同设计关键技术,包括灯饰模型交互设计和同步互斥技术,开发出了一个以客户为主,以设计师为辅并基于Web3D技术的网上协同设计系统,并通过实验验证了系统的可行性.

  19. Haemodynamical stress in mouse aortic arch with atherosclerotic plaques: Preliminary study of plaque progression

    Directory of Open Access Journals (Sweden)

    P. Assemat

    2014-07-01

    Full Text Available Atherosclerotic plaques develop at particular sites in the arterial tree, and this regional localisation depends largely on haemodynamic parameters (such as wall shear stress; WSS as described in the literature. Plaque rupture can result in heart attack or stroke and hence understanding the development and vulnerability of atherosclerotic plaques is critically important. The purpose of this study is to characterise the haemodynamics of blood flow in the mouse aortic arch using numerical modelling. The geometries are digitalised from synchrotron imaging and realistic pulsatile blood flow is considered under rigid wall assumptions. Two cases are considered; arteries with and without plaque. Mice that are fed under fat diet present plaques in the aortic arch whose size is dependent on the number of weeks under the diet. The plaque distribution in the region is however relatively constant through the different samples. This result underlines the influence of the geometry and consequently of the wall shear stresses for plaque formation with plaques growing in region of relative low shear stresses. A discussion of the flow field in real geometry in the presence and absence of plaques is conducted. The presence of plaques was shown to alter the blood flow and hence WSS distribution, with regions of localised high WSS, mainly on the wall of the brachiocephalic artery where luminal narrowing is most pronounced. In addition, arch plaques are shown to induce recirculation in the blood flow, a phenomenon with potential influence on the progression of the plaques. The oscillatory shear index and the relative residence time have been calculated on the geometry with plaques to show the presence of this recirculation in the arch, an approach that may be useful for future studies on plaque progression.

  20. DEVELOPING WHAT CUSTOMERS REALLY NEED: INVOLVING CUSTOMERS IN INNOVATIONS

    OpenAIRE

    MARCEL E. A. WEBER; MATHIEU C. D. P. WEGGEMAN; JOAN E. VAN AKEN

    2012-01-01

    Involving users in new product design and development is in itself not a new phenomenon. Academic research on the subject, however, is relatively new. Since this new millennium research on user involvement in innovations has multiplied, exhibiting that firms who actively involve users in their innovation process can benefit from this initiative, even though literature also warns us for relying too much and too actively on the participation of customers in innovation. However, research is main...

  1. Design and Realization of Customer Relationship Management System%企业客户关系管理系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    张毅智; 陆红梅; 罗颖

    2011-01-01

    客户关系管理(customer relationship management,CRM)是近年来企业采用的一套先进管理方法。CRM的主要含义就是对企业客户的详细资料做出必要的分析,挖掘出客户潜在销售能力,从而提高企业盈利能力。企业客户关系管理系统可以科学、高效地管理企业的客户资源,保存企业与客户进行商业活动相关资料,因此,快捷、准确、方便、高效的客户关系管理系统可以更好地为客户提供优质的服务,为企业的带来更大的经济效益。%Customer Relationship Management,CRM,is an advanced method in an enterprise today.CRM's main implication aims at making a necessary analysis of customers' materials and digging out their potential sales capacity so as to improve the enterprise profitting capacity.Customer Relationship Management can manage the customer resource scientifically and efficiently,keeping with relevant materials about business activities between the enterprise and customers.Thus this quick,accurate,convenient and efficient CRM system can provide the high quality service and bring in more economic benefits to the enterprise.

  2. Mass Customization and Personalization Prospects in Developing Country: Indonesian Context

    Science.gov (United States)

    Risdiyono; Djati Widodo, Imam; Mahtarami, Affan

    2016-01-01

    The advancement of information technology (IT) has changed many modes and ways for people in doing their businesses. Mass Customization and Personalization (MCP) is one example of business modes that has been dramatically evolve, mainly due to the currently very fast IT development. MCP has enabled people to involve in adjusting some design parameters of a product to meet their personal requirements before purchased. The advancement of IT has made MCP more successful as it makes the process faster, easier, simpler and more joyful. The success stories of MCP are easily found in many developed countries, where the IT infrastructure has firmly been established. For developing countries, there are very few industries have implemented the MCP concept, including Indonesia. This paper discusses a descriptive study to depict what people think about MCP implementation in Indonesia especially in Small and Medium Enterprises (SMEs). Kano model was used to see the perception of both producers and consumers in relation with MCP implementation. Five dummy MCP prototypes were developed for five creative products including plaques, hats, invitation card, t-shirts and leather bags. Based on the KANO questionnaire analyses, it is clear that there are big opportunities to implement MCP in Indonesia especially for creative products produced by SMEs. Identifying the correct product features is an important key for successful MCP implementation in developing countries.

  3. Pregnancy associated plasma protein-A (PAPP-A) is not a marker of the vulnerable atherosclerotic plaque

    DEFF Research Database (Denmark)

    Iversen, Kasper K; Teisner, Ane Søgaard; Dalager, Soren

    2011-01-01

    OBJECTIVE: To investigate if pregnancy associated plasma protein-A (PAPP-A) was present in the vulnerable plaque, and if not, to find alternative hypothesis for the release of PAPP-A. DESIGN AND METHODS: Vulnerable plaques and control tissues were examined by immunohistochemistry. Volunteers...

  4. Numerical observer for atherosclerotic plaque classification in spectral computed tomography.

    Science.gov (United States)

    Lorsakul, Auranuch; Fakhri, Georges El; Worstell, William; Ouyang, Jinsong; Rakvongthai, Yothin; Laine, Andrew F; Li, Quanzheng

    2016-07-01

    Spectral computed tomography (SCT) generates better image quality than conventional computed tomography (CT). It has overcome several limitations for imaging atherosclerotic plaque. However, the literature evaluating the performance of SCT based on objective image assessment is very limited for the task of discriminating plaques. We developed a numerical-observer method and used it to assess performance on discrimination vulnerable-plaque features and compared the performance among multienergy CT (MECT), dual-energy CT (DECT), and conventional CT methods. Our numerical observer was designed to incorporate all spectral information and comprised two-processing stages. First, each energy-window domain was preprocessed by a set of localized channelized Hotelling observers (CHO). In this step, the spectral image in each energy bin was decorrelated using localized prewhitening and matched filtering with a set of Laguerre-Gaussian channel functions. Second, the series of the intermediate scores computed from all the CHOs were integrated by a Hotelling observer with an additional prewhitening and matched filter. The overall signal-to-noise ratio (SNR) and the area under the receiver operating characteristic curve (AUC) were obtained, yielding an overall discrimination performance metric. The performance of our new observer was evaluated for the particular binary classification task of differentiating between alternative plaque characterizations in carotid arteries. A clinically realistic model of signal variability was also included in our simulation of the discrimination tasks. The inclusion of signal variation is a key to applying the proposed observer method to spectral CT data. Hence, the task-based approaches based on the signal-known-exactly/background-known-exactly (SKE/BKE) framework and the clinical-relevant signal-known-statistically/background-known-exactly (SKS/BKE) framework were applied for analytical computation of figures of merit (FOM). Simulated data of a

  5. Focusing on customer service.

    Science.gov (United States)

    1996-01-01

    This booklet is devoted to a consideration of how good customer service in family planning programs can generate demand for products and services, bring customers back, and reduce costs. Customer service is defined as increasing client satisfaction through continuous concern for client preferences, staff accountability to clients, and respect for the rights of clients. Issues discussed include the introduction of a customer service approach and gaining staff commitment. The experience of PROSALUD in Bolivia in recruiting appropriate staff, supervising staff, soliciting client feedback, and marketing services is offered as an example of a successful customer service approach. The key customer service functions are described as 1) establishing a welcoming atmosphere, 2) streamlining client flow, 3) personalizing client services, and 4) organizing and providing clear information to clients. The role of the manager in developing procedures is explored, and the COPE (Client-Oriented Provider-Efficient) process is presented as a good way to begin to make improvements. Techniques in staff training in customer service include brainstorming, role playing, using case studies (examples of which are provided), and engaging in practice sessions. Training also leads to the development of effective customer service attitudes, and the differences between these and organizational/staff-focused attitudes are illustrated in a chart. The use of communication skills (asking open-ended questions, helping clients express their concerns, engaging in active listening, and handling difficult situations) is considered. Good recovery skills are important when things go wrong. Gathering and using client feedback is the next topic considered. This involves identifying, recording, and discussing customer service issues as well as taking action on these issues and evaluating the results. The booklet ends by providing a sample of customer service indicators, considering the maintenance of a

  6. Quantification of the uncertainty in coronary CTA plaque measurements using dynamic cardiac phantom and 3D-printed plaque models

    Science.gov (United States)

    Richards, Taylor; Sturgeon, Gregory M.; Ramirez-Giraldo, Juan Carlos; Rubin, Geoffrey; Segars, Paul; Samei, Ehsan

    2017-03-01

    The purpose of this study was to quantify the accuracy of coronary computed tomography angiography (CTA) stenosis measurements using newly developed physical coronary plaque models attached to a base dynamic cardiac phantom (Shelley Medical DHP-01). Coronary plaque models (5 mm diameter, 50% stenosis, and 32 mm long) were designed and 3D-printed with tissue equivalent materials (calcified plaque with iodine enhanced lumen). Realistic cardiac motion was achieved by fitting known cardiac motion vectors to left ventricle volume-time curves to create synchronized heart motion profiles executed by the base cardiac phantom. Realistic coronary CTA acquisition was accomplished by synthesizing corresponding ECG waveforms for gating and reconstruction purposes. All scans were acquired using a retrospective gating technique on a dual-source CT system (Siemens SOMATOM FLASH) with 75ms temporal resolution. Multi-planar reformatted images were reconstructed along vessel centerlines and the enhanced lumens were manually segmented by 5 independent operators. On average, the stenosis measurement accuracy was 0.9% positive bias for the motion free condition (0 bpm). The measurement accuracy monotonically decreased to 18.5% negative bias at 90 bpm. Contrast-tonoise (CNR), vessel circularity, and segmentation conformity also decreased monotonically with increasing heart rate. These results demonstrate successful implementation of the base cardiac phantom with 3D-printed coronary plaque models, adjustable motion profiles, and coordinated ECG waveforms. They further show the utility of the model to ascertain metrics of coronary CT accuracy and image quality under a variety of plaque, motion, and acquisition conditions.

  7. The equipment room power supply system of telecom business and government enterprise customer optimization design%通信运营商政企客户机房供电系统优化设计

    Institute of Scientific and Technical Information of China (English)

    毛文杰

    2014-01-01

    Enterprise customer communication operators are the most important customer resources, which the focus of all telecom enterprises fighting for.To provide a stable, efficient, reliable, safe access services for enterprise customers are the key competition. The article based on the telecom enterprise customer room existing AC, DC power supply system problems and potential safety hazards are also summarized.Study for enterprise customer room high reliability AC, DC power supply system. And through the theoretical calculation and engineering practice, to optimize the power supply system of customer room enterprise implementation scheme.Meanwhile, the article also design the corresponding AC, DC power system optimization diagram.In order to meet the market development and customer, for the communication operators and the safety of power supply system, reliable, reasonable and applicable requirements.%政企客户是通信运营商最重要的客户资源,是各大通信运营企业争夺的焦点,为政企客户提供稳定、高效、可靠、安全的接入服务是竞争胜负的关键;本文通过对电信政企客户机房现有交、直流供电系统存在的问题与安全隐患进行分析总结,着重研究适合政企客户机房高可靠性的交、直流供电系统;并通过理论计算及工程实践,提出优化政企客户机房供电系统的可实施方案,同时设计出相应的交、直流供电系统优化示意图,以满足市场开发及政企客户对于通信运营商供电系统的安全、可靠、合理及适用性要求。

  8. 31 CFR 406.4 - Duties of customs officers.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Duties of customs officers. 406.4... 1934 AND GOLD REGULATIONS § 406.4 Duties of customs officers. The appropriate officials of the Bureau of Customs are hereby authorized and designated as the officers who shall perform such...

  9. Measuring Customer Satisfaction. A Central Texas JTPA Study.

    Science.gov (United States)

    Angel, P. Linda

    A study was conducted to determine the baseline by which to measure expected improvements in customer satisfaction for Central Texas Job Training Partnership (JTPA) programs. The survey was designed to facilitate assessment of the current level of customer satisfaction with service delivery and influences on customer satisfaction. Data were…

  10. A Customized Finger Brachytherapy Carrier

    OpenAIRE

    Wadhwa, Supneet Singh; Duggal, Nidhi

    2013-01-01

    In recent years, radiation therapy has been used with increasing frequency in the management of neoplasms of the head and neck region. Brachytherapy is a method of radiation treatment in which sealed radioactive sources are used to deliver the dose a short distance by interstitial (direct insertion into tissue), intracavitary (placement within a cavity) or surface application (molds). Mold brachytherapy is radiation delivered via a custom-fabricated carriers, designed to provide a more consta...

  11. New customer services

    DEFF Research Database (Denmark)

    Münster, Marie; Møller Andersen, Frits; Meza, Maria Josefina Figueroa

    2011-01-01

    This chapter focuses on the challenge of motivating energy service customers to make best use of available smart technologies. This can be done through economic incentives, but also through information and education, regulation and reorganisation, and by improving services or customer comfort...

  12. Analytics for Customer Engagement

    NARCIS (Netherlands)

    Bijmolt, Tammo H. A.; Leeflang, Peter S. H.; Block, Frank; Eisenbeiss, Maik; Hardie, Bruce G. S.; Lemmens, Aurelie; Saffert, Peter

    2010-01-01

    In this article, we discuss the state of the art of models for customer engagement and the problems that are inherent to calibrating and implementing these models. The authors first provide an overview of the data available for customer analytics and discuss recent developments. Next, the authors di

  13. Managing customer service.

    Science.gov (United States)

    Paget, Zoe

    2015-02-28

    Zoe Paget is the customer services manager at YourVets. Her role includes managing the company's call centre, social media marketing, working with the marketing department to develop customer care initiatives and reporting service levels to the company's directors. British Veterinary Association.

  14. Analytics for Customer Engagement

    NARCIS (Netherlands)

    Bijmolt, Tammo H. A.; Leeflang, Peter S. H.; Block, Frank; Eisenbeiss, Maik; Hardie, Bruce G. S.; Lemmens, Aurelie; Saffert, Peter

    In this article, we discuss the state of the art of models for customer engagement and the problems that are inherent to calibrating and implementing these models. The authors first provide an overview of the data available for customer analytics and discuss recent developments. Next, the authors

  15. British Sign Name Customs

    Science.gov (United States)

    Day, Linda; Sutton-Spence, Rachel

    2010-01-01

    Research presented here describes the sign names and the customs of name allocation within the British Deaf community. While some aspects of British Sign Language sign names and British Deaf naming customs differ from those in most Western societies, there are many similarities. There are also similarities with other societies outside the more…

  16. English Idioms and Customs

    Institute of Scientific and Technical Information of China (English)

    张小乔

    2015-01-01

    Customs is a kind of social phenomenon. They are not the product of individuals but that of the collective in the society,which are affected by politics, economy, religion, literary art and so on and then affect those things in reverse. English idioms aregreatly influenced by English customs.

  17. REGIONAL CUSTOMS DIRECTORATES MANAGEMENT

    Directory of Open Access Journals (Sweden)

    CABA STEFAN

    2009-05-01

    Full Text Available The management of a regional customs directorate is analyzed. A new approach of the managerial system, in the European integration context, is presented. The customs system is one of the first “doors” to a new economic, social and cultural community. For

  18. Managing Global Customers

    NARCIS (Netherlands)

    G.S. Yip (George)

    2009-01-01

    textabstractMultinational companies need to manage their relationships with multinational customers in a globally integrated approach. This paper provides a systematic framework for developing and implementing such global customer management programmes. The paper is based on Chapter 1 of George S. Y

  19. Customer Relationship Management.

    Science.gov (United States)

    Fayerman, Michael

    2002-01-01

    Presents an approach increasingly employed by businesses to track and respond to their customers to provide better and faster services: customer relationship management. Discusses its applicability to the operations of higher education and institutional research and the role it plays in the knowledge management framework. (EV)

  20. Customs Modernization Handbook

    OpenAIRE

    De Wulf, Luc; Sokol, José B.

    2005-01-01

    This handbook aims to make a positive contribution to the efforts that many countries are undertaking to modernize their customs administrations. The handbook views a competent and well-organized customs service as one that successfully balances its various responsibilities to ensure a high level of compliance with revenue objectives and regulatory requirements while at the same time inter...

  1. Managing Global Customers

    NARCIS (Netherlands)

    G.S. Yip (George)

    2009-01-01

    textabstractMultinational companies need to manage their relationships with multinational customers in a globally integrated approach. This paper provides a systematic framework for developing and implementing such global customer management programmes. The paper is based on Chapter 1 of George S.

  2. Customer Relationship Management.

    Science.gov (United States)

    Fayerman, Michael

    2002-01-01

    Presents an approach increasingly employed by businesses to track and respond to their customers to provide better and faster services: customer relationship management. Discusses its applicability to the operations of higher education and institutional research and the role it plays in the knowledge management framework. (EV)

  3. Keeping Your Customers Satisfied.

    Science.gov (United States)

    Maurer, Mary E.

    1996-01-01

    Notes that because child care is a customer-service business with many of the same requirements as any retail business, it is important that providers communicate clearly, help their customers (especially parents), and understand their needs. Offers suggestions for meeting parents' needs and making them feel like active participants in their…

  4. Fibrillar amyloid plaque formation precedes microglial activation.

    Directory of Open Access Journals (Sweden)

    Christian K E Jung

    Full Text Available In Alzheimer's disease (AD, hallmark β-amyloid deposits are characterized by the presence of activated microglia around them. Despite an extensive characterization of the relation of amyloid plaques with microglia, little is known about the initiation of this interaction. In this study, the detailed investigation of very small plaques in brain slices in AD transgenic mice of the line APP-PS1(dE9 revealed different levels of microglia recruitment. Analysing plaques with a diameter of up to 10 μm we find that only the half are associated with clear morphologically activated microglia. Utilizing in vivo imaging of new appearing amyloid plaques in double-transgenic APP-PS1(dE9xCX3CR1+/- mice further characterized the dynamic of morphological microglia activation. We observed no correlation of morphological microglia activation and plaque volume or plaque lifetime. Taken together, our results demonstrate a very prominent variation in size as well as in lifetime of new plaques relative to the state of microglia reaction. These observations might question the existing view that amyloid deposits by themselves are sufficient to attract and activate microglia in vivo.

  5. The desmosomal plaque and the cytoskeleton.

    Science.gov (United States)

    Franke, W W; Cowin, P; Schmelz, M; Kapprell, H P

    1987-01-01

    Two major plasma membrane domains are involved in the architectural organization of the cytoskeleton. Both are junctions of the adherens category characterized by the presence of dense plaques associated with the cytoplasmic surface of their membranes. The plaques serve as specific anchorage structures for two different types of cytoplasmic filaments. Intermediate-sized filaments (IF) of several types, i.e. cytokeratin IF in epithelial cells, desmin IF in cardiac myocytes and vimentin IF in arachnoidal cells of meninges, meningiomas and several other cells, attach to the desmosomal plaques, whereas actin-containing microfilaments associate with non-desmosomal adhering junctions such as the zonula adherens, fascia adherens and punctum adherens. The plaques of both kinds of adhering junctions contain a common acidic polypeptide of Mr 83,000 identical to 'band 5 protein' of bovine snout epidermal desmosomes. However, other plaque components are mutually exclusive to one of the two subclasses of adhering junctions. The desmosomal plaque structure, which does not contain vinculin and alpha-actinin, comprises representatives of cytoplasmic, non-membrane-integrated proteins such as desmoplakin(s) and the cytoplasmic portions of transmembrane glycoproteins such as 'band 3 glycoprotein'. The analysis of both categories of junction-associated plaques should provide a basis for understanding the establishment and the dynamics of junction-cytoskeleton interaction.

  6. Angiogenesis in atherosclerotic plaque obtained from carotid endarterectomy: association between symptomatology and plaque morphology.

    Science.gov (United States)

    Hiyama, Takami; Tanaka, Toshihide; Endo, Shinichi; Komine, Kazumasa; Kudo, Tadashi; Kobayashi, Hiroo; Shiokawa, Yoshiaki

    2010-01-01

    Carotid plaque with hemorrhage leads to cerebral embolism and ischemic stroke. Plaque angiogenesis and angiogenetic factors such as vascular endothelial growth factor (VEGF) are critical in the progression of atherosclerotic carotid plaque and intraplaque hemorrhage. The correlation between plaque angiogenesis and presence of clinical symptoms was studied in 41 specimens obtained during carotid endarterectomy from 20 symptomatic and 21 asymptomatic patients treated for carotid artery stenosis. Histological findings using hematoxylin-eosin and immunohistochemical staining against von Willebrand factor and VEGF were examined. Intraplaque hemorrhage, calcification, necrosis, and invasion of foam cells were frequently observed in the carotid plaques from symptomatic patients compared with asymptomatic patients. Higher microvessel density was found in the carotid plaques with necrosis and invasion of foam cells compared with plaques without necrosis and/or foam cell invasion, and higher expression of VEGF was found from symptomatic patients compared with asymptomatic patents. These results suggest that plaque angiogenesis and higher level of VEGF expression may enhance the progression of ischemic symptoms in patients with carotid artery stenosis. Invasive macrophages in the plaque of symptomatic patients increase levels of VEGF and might enhance plaque angiogenesis and atherosclerosis progression.

  7. Bacterial colonization during de novo plaque formation.

    Science.gov (United States)

    Ramberg, Per; Sekino, Satoshi; Uzel, Naciye Guzin; Socransky, Sigmund; Lindhe, Jan

    2003-11-01

    To determine microbial changes that occur during plaque formation in a dentition free of gingival inflammation. Ten subjects were recruited. The study included one preparatory period (2 weeks) and a plaque accumulation period (4 days). The volunteers exercised proper tooth cleaning methods, were scaled and received repeated professional mechanical tooth cleaning during the preparatory period. During the plaque accumulation period, the participants abstained from plaque control measures. Plaque was scored on the approximal surfaces of maxillary and mandibular premolars on Days 0, 1, 2 and 4 using a scale from 0 to 5 and according to the criteria of the Quigley and Hein Plaque Index (QHI). Supragingival plaque samples were obtained from the same intervals and surfaces and evaluated using a checkerboard DNA-DNA hybridization technique. The mean QHI increased from 0 to 1.6 (Day 4). The total number of organisms on Day 0 averaged 140 x 10(5) and increased to about 210 x 10(5) after 4 days without oral hygiene. The most dominant species on Day 0 were members of the genus Actinomyces. These organisms comprised almost 50% of the microbiota evaluated. None of the Actinomyces species increased significantly during the 4 days. Some Streptococcus species increased significantly over time as well as species of the genera Capnocytophaga, Campylobacter, Fusobacteria and Actinomyces actinomycetemcomitans. In the present investigation, the preparatory phase established a situation with minimal gingival inflammation and close to zero amounts of dental plaque. The Day 0 plaque samples exhibited high proportions of Actinomyces species. During the 4 days of no oral hygiene, there was a small increase in total numbers of organisms as well as a modest increase in the proportion of "disease-associated" taxa such as species of the "orange complex" species.

  8. Apopotic gene Bax expression in carotid plaque

    Institute of Scientific and Technical Information of China (English)

    Bao-Zhong MEN; Ding-Biao ZHOU; Huai-Yin SHI; Xiao-Ming ZHANG

    2006-01-01

    The expression of BAX in carotid atherosclerosis and its regulation is far from defined. Objectives To investigate BAX expression in stable/fibrous and instable/vulnerable carotid plaque and its clinical significance. Methods 25 cases of carotid plaque specimens obtained from endarterectomy were divided into two groups, stable/fibrous 14 cases, vulnerable/instable 11 cases; aortic artery and its branches from hepatic transplantation donors 6 case as control. The expression of proapoptotic BAX was detected by immunohistochemistry(IHC), in situ hybridization(ISH) and in situ TdT dUTP nick end labeling (TUNEL). Results 5 cases of BAX ( + ) were detected by ICH and ISH, 4 case of TUNEL ( + ) were detected by TUNEL in stable/fibrous carotid plaque , while 10 cases were BAX ( + )by IHC(P < 0.05) , 11case by ISH and 9 case by TUNEL were detected in instable/vulnerable carotid plaque ( P < 0.01 ), respectively. The intensity of BAX ( + ) cells by IHC and ISH was 8.63 ± 2.62 and 10.32 ± 3.12 in fibrous plaques, whereas 122 ± 21.64and 152 ± 23.35 in vulnerable plaques, respectively. No expression of BAX was found in controlled group. Conclusion The higher expression of Bax in vulnerable carotid plaque may be one mechanisms in molecular pathogenesis of carotid atherosclerosis which affect plaque stability and be the cause of higher incidence of stroke than fibrous carotid plaques, the regulation of BAX expression in different stage of atherosclerosis may provide targets in gene therapy for carotid atherosclerosis.

  9. Customer relationships marketing

    Directory of Open Access Journals (Sweden)

    Đorđević Bojan

    2005-01-01

    Full Text Available Market economy terms impose on modern companies the need to change their business relationships to customers. In this way has the term "customer relationship marketing", known as CRM, come into use. Customers are the most valuable asset of a company, and the wisdom and essence of CRM can be presented in two words - profitable and long-term. Modern customer is an individual. They are smart, informed, have great expectations and want only the best, and they can change their supplier by one click of the mouse. Every one of them is characterized by specific needs, and, in that sense the company must strive to satisfy them with the right offer at the right time and through the right channel. The aim of the company is to have loyal customers who will help the company make maximized profit and competitive advantage on the market.

  10. CUSTOMER LOYALTY THEORETICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    Margarita IŠORAITĖ

    2016-08-01

    Full Text Available Customer loyalty - is a voluntary user solution for a long time to build relationships with the company. Loyalty is the user's desire for a long time to continue their relationship with a particular company, because loyal customers are those who purchase goods/services of the company from time to time. Loyalty can be treated as a customer desire, willingness to be a regular customer for a long time, buying and using the goods of the chosen companies by recommending them to friends and colleagues. Loyalty can be seen as a multi-dimension, covering behavioral and positional components, where positional aspect reflects customers' approach to business, while the behavioral dimension reveals a frequent and regular shopping, purchase quantity, size, range, availability, etc.

  11. How Customers Choose Hotels

    Directory of Open Access Journals (Sweden)

    Hera Oktadiana

    2011-05-01

    Full Text Available In the advancement of hospitality industry, thus it is important for hotel sales and marketing to understand the customer behavior in order to create effective marketing. Factors that influence customer behavior as individuality consist of personal and interpersonal factors. Personal factors include the needs, wants, motivation, perception, learning, personality, lifestyle, and self-concept. Meanwhile, interpersonal factors come from culture and sub-culture, group references, customers through stages before deciding to purchase. Begin with the awareness about the needs, customers then find information about the product or service that could be used to solve the problems. After having the information, customers select the best product and service before deciding to purchase. After purchasing, the last stage is evaluation of product and service, whether it is satisfying or not.

  12. Design and Realization of a Terminal Analysis System Supporting Customer Segment%一种支撑客户细分的终端分析系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    王锐; 陈丽

    2011-01-01

    提出一种终端分析系统的设计与实现,通过对客户终端信息以及消费行为信息进行数据挖掘分析,精确归类出客户对象族,为市场精确营销和网络运维提供了服务和支撑.%In this paper, the design and realization of a terminal analysis system was proposed. With data mining, based on the terminal information and consuming behavior for customers, the system can cluster the customer segments precisely and support the precision marketing and network operation.

  13. Customer Order Decoupling Point Selection Model in Mass Customization Based on MAS

    Institute of Scientific and Technical Information of China (English)

    XU Xuanguo; LI Xiangyang

    2006-01-01

    Mass customization relates to the ability of providing individually designed products or services to customer with high process flexibility or integration. Literatures on mass customization have been focused on mechanism of MC, but little on customer order decoupling point selection. The aim of this paper is to present a model for customer order decoupling point selection of domain knowledge interactions between enterprises and customers in mass customization. Based on the analysis of other researchers' achievements combining the demand problems of customer and enterprise, a model of group decision for customer order decoupling point selection is constructed based on quality function deployment and multi-agent system. Considering relatively the decision makers of independent functional departments as independent decision agents, a decision agent set is added as the third dimensionality to house of quality, the cubic quality function deployment is formed. The decision-making can be consisted of two procedures: the first one is to build each plane house of quality in various functional departments to express each opinions; the other is to evaluate and gather the foregoing sub-decisions by a new plane quality function deployment. Thus, department decision-making can well use its domain knowledge by ontology, and total decision-making can keep simple by avoiding too many customer requirements.

  14. Magnetic force microscopy of atherosclerotic plaque

    Directory of Open Access Journals (Sweden)

    Alexeeva T.A.

    2014-03-01

    Full Text Available In this work by methods of scanning probe microscopy, namely by atomic force microscopy and magnetic force microscopy the fragments of atherosclerotic plaque section of different nature were investigated. The fragments of atherosclerotic vessels with elements of immature plaque were taken during the coiled artery bypass surgery by alloprosthesis. As the result of investigation we found magnetically ordered phase of endogenous origin in the fragment of solid plaque of mixed structure. This phase is presents biogenic magnetic nanoparticles and their clusters with average size characteristic of 200-400 nm.

  15. ANTESEDEN CUSTOMER LOYALTY PADA LOW COST CARRIER AIRLINE

    OpenAIRE

    Marcella Harlan

    2015-01-01

    The background of this research was Customer loyalty as a competitive advantage in service industry.The design of this research applies a survey toward unit of analysis on Low Cost Carrier Airline to interview the passanger for testing hypothesis. Meanwhile the required data consist of five variables; Recovery Satisfaction, Corporate Social Responsibility, Customer Trust, Customer Loyalty. The aggregate numbers of customer being respondent of the study are 200. Data analysis us...

  16. 燃气CRM系统的设计与应用%Design and Application of Gas Customer Relationship Management (CRM) System

    Institute of Scientific and Technical Information of China (English)

    施明; 刘镝

    2007-01-01

    文章介绍了CRM(Customer Relationship Management即客户关系管理)系统的概念、组成以及设计与应用.CRM的核心思想是"以客户为中心",提高客户满意度,改善企业与客户的关系,从而提高企业的竞争力.

  17. Design of an enhanced Integrated Management System with Customer Experience Focus: The Business Process Framework (also known as eTOM and ISO9001 Together

    Directory of Open Access Journals (Sweden)

    John P. Reilly

    2012-09-01

    Full Text Available The purpose of this paper is to suggest an enhanced Process model with customer experience focus and its related documentation structure applicable to many industrial contexts. Since the Business Process Framework, also known as eTOM, is originally a Process Model for Telco industry and now being used broadly in many industries, ISO9001 is a historical and generic standard with customer focus, and there is always a question about how to integrate the Business Process Framework and ISO9001, the enhanced process model will be based on the integration of the Business Process Framework and ISO9001 highlighting the customer aspects to meet the current trends within Telco and many other industries. The management system, containing the organization, the processes based on this integration, and the performance management system is called an Integrated Management System (IMS. The paper focus is on the processes and its introduction is about Telco Business context since the Business Process Framework was born within this industry. But, the suggested IMS is applicable to many service companies and many organizational units of any industry (Ex.: any Information System organizational unit, with its service Portfolios, of any industry since the Business Process Framework and ISO9001 are too.

  18. CUSTOMER RELATIONSHIP MANAGEMENT AND BUSINESS STRATEGIES

    Directory of Open Access Journals (Sweden)

    Rozitta Chittaie

    2012-06-01

    Full Text Available Changing in the current competitive environment, increasing simplicity of penetrating into the competitive market, and rapid growing of information technology are essential motives for performing activities in an environment. Nowadays, some companies step into rapid and instant development of their markets in order to improve customer relationship. These companies through adopting customer relationship management (CRM systems can earn and retain their customers' loyalty. As a result, designing customer relationship management strategies can lead to market protection, customer value increase, and greater customer satisfaction opportunities for continuous promotion of the enterprise. Regarding the complexity and the variety of strategies associated with managing a business, information-related capability seems to be an essential capability for earning profit from companies' activities and competition among peers. Hence, relation and information are employed for managing the firms are vital tools for seizing opportunities and tackling future issues. Giving the information only employed to support a company’s performance, making crucial decision about surrounding environment, increasing competitive ability of the enterprise will be difficult for company. Furthermore, since increase of competitive ability is accompanied by making greater profit on the deal, methods of raising competitive ability is an interesting and critical issue. Therefore, companies through information technology, cost reduction, and development of low-level relations with customers can achieve greater profitability. This paper probes into customer relationship management and business strategies. The implications of CRM strategies are discussed in detail.

  19. Customer Clustering Based on Customer Purchasing Sequence Data

    Directory of Open Access Journals (Sweden)

    Yen-Chung Liu

    2017-01-01

    Full Text Available Customer clustering has become a priority for enterprises because of the importance of customer relationship management. Customer clustering can improve understanding of the composition and characteristics of customers, thereby enabling the creation of appropriate marketing strategies for each customer group. Previously, different customer clustering approaches have been proposed according to data type, namely customer profile data, customer value data, customer transaction data, and customer purchasing sequence data. This paper considers the customer clustering problem in the context of customer purchasing sequence data. However, two major aspects distinguish this paper from past research: (1 in our model, a customer sequence contains itemsets, which is a more realistic configuration than previous models, which assume a customer sequence would merely consist of items; and (2 in our model, a customer may belong to multiple clusters or no cluster, whereas in existing models a customer is limited to only one cluster. The second difference implies that each cluster discovered using our model represents a crucial type of customer behavior and that a customer can exhibit several types of behavior simultaneously. Finally, extensive experiments are conducted through a retail data set, and the results show that the clusters obtained by our model can provide more accurate descriptions of customer purchasing behaviors.

  20. the customer at the final frontier of mass customization

    DEFF Research Database (Denmark)

    Svensson, Carsten; Jensen, Thomas

    2002-01-01

    Mass customisation is no longer new. A decade of industrial experience have shown how this business paradigm have been used – and abused. Like any other evolutionary process of a business paradigm, the exploitation of mass customisation may be expected to stabilise as it matures. In this article......, some of the factors influencing the use of this business paradigm are discussed and it is argued that the customer is the major limiting factor at the final frontier of mass customisation. Until recently mass customisation have mainly been turned towards the structural design of products, whereas...... this paper argues that there might be a need for an increased focus on the fulfilment of customer needs. As a result of this manufactures will have to hone the balance of trade-offs, as the paradigm of mass customisation becomes a commodity....

  1. Are all customers really the same? Comparing service quality and satisfaction between residential and business telecommunications customers

    Directory of Open Access Journals (Sweden)

    Charles Makanyeza

    2016-03-01

    Full Text Available Orientation: The study focused on the moderating role of the type of customer on the relationship between service quality and customer satisfaction.Research purpose: The study sought to examine differences in the relationship between service quality and customer satisfaction because of the type of customer.Motivation for the study: Previous studies have not examined the relationship between service quality and customer satisfaction between residential and business customers.Research design, approach and method: The study used a cross-section of 203 customers (108 residential and 95 business in the fixed-line telecommunications sector in Zimbabwe. Moderated regression analysis was performed to test the research hypotheses.Main findings: It was established that the customer category (residential versus business does not moderate the effect of service quality on customer satisfaction. Practical/managerial implications are, generally, that it is not necessary to segment customers by customer category (residential versus business when managing service quality to achieve customer satisfaction.Contribution/value add: The main theoretical contribution of the study is the comparison of the effect of service quality on customer satisfaction between residential and business customers.

  2. When to "Fire" Customers: Customer Cost-Based Pricing

    OpenAIRE

    Jiwoong Shin; Sudhir, K.; Dae-Hee Yoon

    2012-01-01

    The widespread adoption of activity-based costing enables firms to allocate common service costs to each customer, allowing for precise measurement of both the cost to serve a particular customer and the customer's profitability. In this paper, we investigate how pricing strategies based on customer cost information affects a firm's customer acquisition and retention dynamics, and ultimately its profit, using a two-period monopoly model with high- and low-cost customer segments. Although past...

  3. Customer Loyalty Research : Can customer loyalty programs really build loyalty?

    OpenAIRE

    Romppanen, Maiju; Kellgren, Cecilia; Moradi, Ladan

    2007-01-01

    Background: During the last decades the efforts to foster customer relationships have become important due to increased competition in the consumer markets. One of the most popular strategies have been to introduce customer loyalty programs which are believed to enhance the customer loyalty. The popularity of the customer loyalty programs is based on the beliefs that loyal customers are lucrative and these programs would bond the customers to the company. More recently however, the discussion...

  4. Large plaque parapsoriasis in a child

    OpenAIRE

    Das Jayanta; Gangopadhyay Asok

    2005-01-01

    A case of large plaque parapsoriasis with extensive skin lesions is presented for its unusual clinical features. The controversial issue of its nosological position is discussed as it has a considerable impact on the management of such cases.

  5. Sticky Brain 'Plaques' Implicated in Alzheimer's Again

    Science.gov (United States)

    ... fullstory_166550.html Sticky Brain 'Plaques' Implicated in Alzheimer's Again Researchers believe these substances form in early ... in the brain signals an early stage of Alzheimer's disease. It's been known for years that in ...

  6. 面向用户在线体验的服装快速个性化设计方法%Personal garment rapid design based on customer online experience

    Institute of Scientific and Technical Information of China (English)

    陈罡; 陈健; 王进; 陈起进; 毕新宇; 陆国栋

    2012-01-01

    A new garment rapid design method is proposed, which lets customers have the opportunities to participate into the design, offering a better experience for customers in the interaction during designing. 3-D garment curve templates can be classified and built based on the topology clustering from the garment knowledge, and rapid generation of clothing is achieved. The interactive texture design has been studied and a creative editing method of the clothing style picture is advanced based on the RBF algorithm. Customers can experience the transformation in the style profile and partial graphic and then edit the clothing style pattern according to personal preferences. And finally, the personalized version of garment model is adjusted to meet the individual requirements in the style picture and curve template.%根据服装产业的需求,采用体验式设计方法,让消费者参与融入设计中,使其能在交互设计中感受到美好体验.根据服装知识,基于拓扑聚类对三维服装曲面模板进行分类并构建,实现服装的快速生成;对服装互动纹理设计技术进行研究,基于RBF算法对服装的款式图片进行创意编辑;用户可以体验款式廓型变形与局部图案的变形,并根据个人喜好编辑服装款式图案;最后在款式图片与曲面模板的基础上,根据客户要求对个性版型服装进行构建修整.

  7. RFM customer profitability analysis

    Directory of Open Access Journals (Sweden)

    Marinković Veljko

    2008-01-01

    Full Text Available Measuring the customer profitability is a very important activity for each and every modern marketing oriented firm. By identifying profitable customer segments, the efficiency and the effectiveness of the marketing strategies can be significantly improved. One of the best-known methods for identifying the most valuable customers is the RFM method. The application of this method is particularly important in the decision-making process related to justification of the application of the various direct marketing strategies, and especially when the introduction of the new product into the market is the key issue.

  8. Customs control of goods

    Directory of Open Access Journals (Sweden)

    Mentor Gashi

    2015-11-01

    Full Text Available Customs control, is regulated by law in different countries. Different countries define through the law, the control of goods.. Main purpose of this paper is to analyze two types of customs controls, and their effect in reducing avoidance of duty or tax evasion which may be caused by the import of goods of certain companies. For this reason we researched which model is implemented in developing countries and what results were reached through questionnaires. In this sense the next research question, consists in defining the moment of customs control pre or post-clearance control of goods.

  9. Customer Communication Document

    Science.gov (United States)

    2009-01-01

    This procedure communicates to the Customers of the Automation, Robotics and Simulation Division (AR&SD) Dynamics Systems Test Branch (DSTB) how to obtain services of the Six-Degrees-Of-Freedom Dynamic Test System (SDTS). The scope includes the major communication documents between the SDTS and its Customer. It established the initial communication and contact points as well as provides the initial documentation in electronic media for the customer. Contact the SDTS Manager (SM) for the names of numbers of the current contact points.

  10. Atherosclerotic Aortic Plaques Detected by Transesophageal Echocardiography

    Institute of Scientific and Technical Information of China (English)

    赵云; 朱文玲; 倪超; 郭丽琳; 曾勇; 方理刚

    2002-01-01

    Objective To evaluate the predictive value of atherosclerotic aortic plaques in coronary artery disease (CAD) Methods In 50patients with suspected coronary artery disease, transesophageal echocardiography was performed to examine their thoracic aortas 2 weeks before or after coronary angiography. In the cases of coronary angiography studied, stenosis of the coronary artery ≥ 50 % was considered to be due to coronary artery disease,whereas the thickness of the intima ≥ 1.3 mm was taken to be the criteria for the presence of an atherosclerotic aortic plaque on the transesophageal echocardiographic test. Results Among the 50 patients, 37 cases were diagnosed as CAD and 13 cases were considered to be normal. The plaques of the thoracic aorta were observed in 34cases in the CAD group and 3 cases in the normal group. The sensitivity and specificity of aortic plaques for CAD were 91.9 % and 76.9%, respectively. The positive and negative predictive values of the aortic plaques for CAD were 91.9% and 76.9%, respectively. The accuracy was 88.0%. 80 percent of the patients with single- yes sel disease had thoracic aortic plaques, 92 percent of the patients with two-vessel disease and 100 percent of the patients with three-vessel disease had thoracic aortic plaques. There was a significant difference in the thickness of aortic intimas between the normal group and the CAD group. Conclusions Detectingatherosclerotic plaques in the thoracic aorta with transesophageal echocardiography may be of great value in predicting the presence and extent of coronary artery disease.

  11. Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin.

    Directory of Open Access Journals (Sweden)

    Sara Hägg

    Full Text Available BACKGROUND: The stability of atherosclerotic plaques determines the risk for rupture, which may lead to thrombus formation and potentially severe clinical complications such as myocardial infarction and stroke. Although the rate of plaque formation may be important for plaque stability, this process is not well understood. We took advantage of the atmospheric (14C-declination curve (a result of the atomic bomb tests in the 1950s and 1960s to determine the average biological age of carotid plaques. METHODOLOGY/PRINCIPAL FINDING: The cores of carotid plaques were dissected from 29 well-characterized, symptomatic patients with carotid stenosis and analyzed for (14C content by accelerator mass spectrometry. The average plaque age (i.e. formation time was 9.6±3.3 years. All but two plaques had formed within 5-15 years before surgery. Plaque age was not associated with the chronological ages of the patients but was inversely related to plasma insulin levels (p = 0.0014. Most plaques were echo-lucent rather than echo-rich (2.24±0.97, range 1-5. However, plaques in the lowest tercile of plaque age (most recently formed were characterized by further instability with a higher content of lipids and macrophages (67.8±12.4 vs. 50.4±6.2, p = 0.00005; 57.6±26.1 vs. 39.8±25.7, p<0.0005, respectively, less collagen (45.3±6.1 vs. 51.1±9.8, p<0.05, and fewer smooth muscle cells (130±31 vs. 141±21, p<0.05 than plaques in the highest tercile. Microarray analysis of plaques in the lowest tercile also showed increased activity of genes involved in immune responses and oxidative phosphorylation. CONCLUSIONS/SIGNIFICANCE: Our results show, for the first time, that plaque age, as judge by relative incorporation of (14C, can improve our understanding of carotid plaque stability and therefore risk for clinical complications. Our results also suggest that levels of plasma insulin might be involved in determining carotid plaque age.

  12. 一种算子自定义小波薄板单元及应用%An operator custom-design wavelet-based thin plate element and its application

    Institute of Scientific and Technical Information of China (English)

    汪友明; 王文庆; 沈建冬; 曹宏瑞

    2014-01-01

    提出了基于提升方案的自适应算子自定义小波有限元法,构造了一种新的算子自定义小波薄板单元。建立二维 Hermite型有限元多分辨空间和两尺度关系,并由广义变分原理推导薄板结构关于尺度函数和小波函数的内积关系式,即算子。为满足算子正交性,提出基于提升方案的算子自定义小波单元的构造方法,其优点在于可根据问题的需要来设计具有期望特性的小波基。提出基于两尺度误差的自适应算子自定义小波有限元方法,通过向大于误差阈值的局域添加算子自定义小波,实现薄板结构问题的高效求解。算子自定义小波有限元法节省了重新划分网格或提高插值函数的阶次所带来的大量有限元前处理时间,并且实现薄板问题的高效解耦运算。%An adaptive operator custom-design wavelet finite element method based on the lifting scheme is proposed and a new operator custom-design wavelet thin plate element is constructed .A two-dimen-sional Hermite-type multiresolution finite element space and two-level relation are built .The inner pro-duction equation of scaling functions and wavelet functions of thin plate structure ,also called the opera-tor ,is derived based on the general variational principle .The construction method of operator custom-design wavelet finite elements based on the lifting scheme is presented to meet the operator-orthogonal-ization .The property of the method is that the wavelets can be designed with the specified feature depen-ding on the requirements of the problems .An adaptive operator custom-design wavelet finite element method is presented on the two-level error estimation ,which can solve the thin plate problems efficiently by adding operator custom-design wavelets into the local domains higher than the threshold value .The operator custom-design wavelet finite element method saves a great deal of preprocessing time of refining the

  13. Effects of cast gold surface finishing on plaque retention.

    Science.gov (United States)

    Keenan, M P; Shillingburg, H T; Duncanson, M G; Wade, C K

    1980-02-01

    The relationship between the surface finish on cast gold restorations and the amount of plaque deposited on that surface was examined. Six different finishes were tested. The rough finish was found to accumulate significantly less plaque than the other finishes. Every finish exhibited some plaque accumulation, even after the first 24 hours. Each finish accumulated progressively more plaque at each successive time interval.

  14. [Is regression of atherosclerotic plaque possible?

    Science.gov (United States)

    Páramo, José A; Civeira, Fernando

    As it is well-known, a thrombus evolving into a disrupted/eroded atherosclerotic plaque causes most acute coronary syndromes. Plaque stabilization via reduction of the lipid core and/or thickening of the fibrous cap is one of the possible mechanisms accounted for the clinical benefits displayed by different anti-atherosclerotic strategies. The concept of plaque stabilization was developed to explain how lipid-lowering agents could decrease adverse coronary events without substantial modifications of the atherosclerotic lesion ('angiographic paradox'). A number of imaging modalities (vascular ultrasound and virtual histology, MRI, optical coherence tomography, positron tomography, etc.) are used for non-invasive assessment of atherosclerosis; most of them can identify plaque volume and composition beyond lumen stenosis. An 'aggressive' lipid-lowering strategy is able to reduce the plaque burden and the incidence of cardiovascular events; this may be attributable, at least in part, to plaque-stabilizing effects. Copyright © 2016 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

  15. Large plaque parapsoriasis: clinical and genotypic correlations.

    Science.gov (United States)

    Simon, M; Flaig, M J; Kind, P; Sander, C A; Kaudewitz, P

    2000-02-01

    Twelve patients with large plaque parapsoriasis (LPP) were investigated for the presence of predominant T-cell clones, analyzing the T-cell receptor (TCR) gamma-chain gene. The diagnostic and prognostic significance of TCR gene rearrangement status was assessed by a correlation with the long-term clinical follow-up. Six out of 12 patients showed a clonal T-cell population. Clinically, among the patients with clonal disease one developed clearcut mycosis fungoides (MF) after a follow-up of 8 years, in the other 5 patients no such diagnosis could be made after follow-up of 2-21 years (median: 9 years). In patients with polyclonal infiltrates the lesions remained virtually unchanged. These findings indicate that in LPP TCR gene rearrangement status has no prognostic significance and does not allow distinction of LPP and early MF. Both conditions show a clonal T-cell infiltrate with similar frequency, are very similar in clinical and histologic presentation and according to recent studies share the same low risk to develop overt MF. Therefore both terms refer to the identical clinical situation. This should be designated as early MF and efforts should concentrate on identifying those patients that are at risk to develop aggressive disease.

  16. Get inside the lives of your customers.

    Science.gov (United States)

    Seybold, P B

    2001-05-01

    Many companies have become adept at the art of customer relationship management. They've collected mountains of data on preferences and behavior, divided buyers into ever-finer segments, and refined their products, services, and marketing pitches. But all too often those efforts are too narrow--they concentrate only on the points where the customer comes into contact with the company. Few businesses have bothered to look at what the author calls the customer scenario--the broad context in which customers select, buy, and use products and services. As a result, consultant Patricia Seybold maintains, they've routinely missed chances to deepen loyalty and expand sales. In this article, the author shows how effective three very different companies have been at using customer scenarios as the centerpiece of their marketing plans. Chip maker National Semiconductor looked beyond the purchasing agents that buy in bulk to find ways to make it easier for engineers to design National's components into their specifications for mobile telephones. Each time they do so, it translates into millions of dollars in orders. By developing a customer scenario that describes how people actually shop for groceries, Tesco learned the importance of decentralizing its Web shopping site and how the extra costs of decentralization could be outweighed by the higher profit margins on-line customers generate. And Buzzsaw.com used customer scenarios as the basis for its entire business. It has used the Web to create a better way for the dozens of participants in a construction project to share their drawings and manage their projects. Seybold lays out the steps managers can take to develop their own customer scenarios. By thinking broadly about the challenges your customers face, she suggests, you can almost always find ways to make their lives easier--and thus earn their loyalty.

  17. 面向业务的敏捷界面定制构件的设计%Design of business-oriented agile interface customization component

    Institute of Scientific and Technical Information of China (English)

    王刚; 程建平

    2012-01-01

    针对传统表单定制的缺点,提出一种面向业务的敏捷界面定制构件Xcom-Vtemplet。介绍了传统表单实现模式及所存在问题,阐述了Xcom—Vtemplet构件的体系结构、设计、开发接口、相关技术以及具体实现应用。实践表明,通过应用Xcom—Vtemplet构件实现了信息项及界面布局的可视化灵活定制;具有即时调整、即时生效的快速应用能力;便于二次开发及业务产品创新敏捷化,节省了项目资源;同时也大大减少了表单维护的工作量,降低了表单维护的难度。%This paper, which eontraposes the disadvantages of the traditional form customization component, puts forward a kind of the business-oriented agile interface customization component--Xcom-Vtemplet. This paper introduces the mode of the traditional form and its numerous problems, and elaborates the system structure, exeogitation, development interface, relevant technology and specific application of Xeom-Vtemplet. The practice shows that Xcom-Vtemplet achieves the visual flexible customization of the information items and interface layout; has the fast application capacity of immediate adjustment and effect; is easy to develop next time and product innovation and agile, and saves project resource; improves the effectiveness, reduces the workload and hardness of the form maintenance.

  18. PENGEMBANGAN CUSTOMER RELATIONSHIP MANAGEMENT BERBASIS SISTEM E-COMMERCE

    Directory of Open Access Journals (Sweden)

    Sugiarto Montana

    2010-10-01

    Full Text Available PT Dwisanjaya Abadi Mukti is a company engaged in distributing Pertamina lubricating agent with products for industrial and automotive lubricants. Therefore, companies need a Customer Relationship Management E-commerce-based systems, to address the issues of purchasing and service to customers that are still conducted manually. Systems analysis is done through observation interviews, and literature; analysis of survey findings; and identification of information needs from survey. The system is designed to give advantage to the user as to obtain the desired information quickly, to acquire new customers, improve customer relationships, and retain customers; other than that for the company this system reduces operating costs, more efficient time, accessible anytime and anywhere, improving work productivity, increase sales, increase the number of customers, and improve customer satisfaction.Keywords: customer relationship management, e-commerce, front end, back end

  19. Perancangan E-Customer Relationship Management Pada Pt Starsindo Logistics

    Directory of Open Access Journals (Sweden)

    Nelly Nelly

    2010-12-01

    Full Text Available Starsindo Logistics Inc. (SL is a company in freight forwarding service. The problem in this company is less information provided to customers, especially about customer order status information. It is started from the departure of the EMKL truck until the standard time of customer container entering freight process. Therefore, it is needed to use the customer service application electronic-Customer Relationship Management (e-CRM, because it will ease to manage and control information flow about the customer order status. The research method is following rules in object oriented analysis and design by Mathiassen. Through website, public is hoped to easily access the company information or ship schedule, order list, tracking order status, or transaction history. This web-based customer service application could help the company to build a good relationship with customers

  20. CSHURI - Modified HURI algorithm for Customer Segmentation and Transaction Profitability

    CERN Document Server

    Pillai, Jyothi

    2012-01-01

    Association rule mining (ARM) is the process of generating rules based on the correlation between the set of items that the customers purchase.Of late, data mining researchers have improved upon the quality of association rule mining for business development by incorporating factors like value (utility), quantity of items sold (weight) and profit. The rules mined without considering utility values (profit margin) will lead to a probable loss of profitable rules. The advantage of wealth of the customers' needs information and rules aids the retailer in designing his store layout[9]. An algorithm CSHURI, Customer Segmentation using HURI, is proposed, a modified version of HURI [6], finds customers who purchase high profitable rare items and accordingly classify the customers based on some criteria; for example, a retail business may need to identify valuable customers who are major contributors to a company's overall profit. For a potential customer arriving in the store, which customer group one should belong ...

  1. From Engineer-To-Order to Mass Customization

    DEFF Research Database (Denmark)

    Haug, Anders; Ladeby, Klaes Rohde; Edwards, Kasper

    2009-01-01

    Purpose - Most mass customization literature focuses on the move from mass production to mass customization. However, in some literature engineer-to-order (ETO) companies are also claiming to have become mass customizers, although it can be questioned if these companies conform to popular...... definitions of mass customizers. The purpose of this paper is to ask the question: under which conditions is it reasonable to label ETO companies as mass customizers? Design/methodology/approach - First, definitions of mass customization are examined and related to ETO companies that move towards mass...... customization. Second, the individual transitions from mass production and ETO to mass customization are analyzed by: relating the transition to classifications from relevant literature; describing the motivations and risks associated with the transition; and defining some of the most important transition...

  2. Research on Manchu customs

    Institute of Scientific and Technical Information of China (English)

    赵昕

    2013-01-01

    As a minority in china, Manchu developed a rich colorful and splendid culture. It is worthwhile studying on its fairy tales, funeral rituals, marriage conventions, sacrificial practices, child-birth and raising customs as well as taboos.

  3. Large Customers (DR Sellers)

    Energy Technology Data Exchange (ETDEWEB)

    Kiliccot, Sila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2011-10-25

    State of the large customers for demand response integration of solar and wind into electric grid; openADR; CAISO; DR as a pseudo generation; commercial and industrial DR strategies; California regulations

  4. Arkitektur & Mass customization

    DEFF Research Database (Denmark)

    Ryborg Jørgensen, Thomas

    2007-01-01

    Publikationens ambition er at udrede og give indblik i produktindustriens seneste udvikling med forretnings- og produktionsstrategien Mass Customization, og dermed en indgang til de muligheder og problemer der knytter sig til implementering af disse eller tilsvarende strategier i byggebranchen, og...

  5. ASD Customer Satisfaction Survey

    Data.gov (United States)

    Department of Veterans Affairs — ASD implemented a customer satisfaction survey for our products and services. This feedback will provide a better understanding of how ASD products and services can...

  6. Customer Innovation Process Leadership

    DEFF Research Database (Denmark)

    Lindgren, Peter; Jørgensen, Jacob Høj; Goduscheit, René Chester

    2007-01-01

    Innovation leadership has traditionally been focused on leading the companies' product development fast, cost effectively and with an optimal performance driven by technological inventions or by customers´ needs. To improve the efficiency of the product development process focus has been...... on different types of organisational setup to the product development model and process. The globalization and enhanced competitive markets are however changing the innovation game and the challenge to innovation leadership Excellent product development innovation and leadership seems not any longer to enough...... another outlook to future innovation leadership - Customer Innovation Process Leadership - CIP-leadership. CIP-leadership moves the company's innovation process closer to the customer innovation process and discusses how companies can be involved and innovate in customers' future needs and lead...

  7. Customer satisfaction and business excellence

    DEFF Research Database (Denmark)

    Kristensen, Kai; Martensen, Anne; Grønholdt, Lars

    , customer loyalty and performance, and optimal customer satisfaction is characterized which will help management choose the right quality parameters for improvement. Second, the paper describes empirical evidence that customer satisfaction measures, based on a modelling approach, have impact on economic......The topic for this paper is the link between customer satisfaction and business performance, which makes it possible to use customer satisfaction measures as basis for creating business excellence. First, the paper presents microeconomic models for the relationship between customer satisfaction...

  8. Customer satisfaction and business excellence

    DEFF Research Database (Denmark)

    Kristensen, Kai; Martensen, Anne; Grønholdt, Lars

    The topic for this paper is the link between customer satisfaction and business performance, which makes it possible to use customer satisfaction measures as basis for creating business excellence. First, the paper presents microeconomic models for the relationship between customer satisfaction......, customer loyalty and performance, and optimal customer satisfaction is characterized which will help management choose the right quality parameters for improvement. Second, the paper describes empirical evidence that customer satisfaction measures, based on a modelling approach, have impact on economic...

  9. Preventing customer defection and stimulating return of the lost customers

    Directory of Open Access Journals (Sweden)

    Senić Radoslav

    2013-01-01

    Full Text Available Customers represent company's most valuable asset. Company can assure its survival, further growth and development by retaining existing, attracting new and returning lost customers. Retaining existing, loyal customers is the most profitable business activity, attracting new ones is the most expensive, while returning lost and frequently forgotten customers is a type of business activity that still generates modest interest among researchers and practitioners. So far, marketing strategies have been mainly directed towards the first two categories of customers. The objective of this paper is dedicated to customer defection and returning lost customers. Paper discusses customer relationship life-cycle and the significance of managing customer return within it, types of customer defections, the process of managing return, as well as, the reasons that led to customer defection.

  10. Customer relationship marketing

    OpenAIRE

    Sæter, Jan Øyvind

    2006-01-01

    Customer relationship marketing has become an interesting choice of strategy for companies in today’s competitive markets. Different positioning strategies like price and product quality are easy to imitate, eluding the importance of sustainable competitive advantage. The customers need to be attracted and bonded towards the store through relationships. The paper discusses several factors affecting relationship marketing and the advantages with this strategy. Through the the...

  11. CUSTOMER RELATIONSHIP MANAGEMENT

    OpenAIRE

    Ioan Bordean; Alina Raileanu

    2008-01-01

    In order to maintain in a market economy with the competition becoming increasingly tough, with consumer preferences and demands more sophisticated and diverse, a company must manage in the best possible way the relations with the existing and potential customers to know their preferences, attitudes, purchasing behaviour, motivations, in order to attract the proper clients for their company products. These goals may be achieved by implementing a strategy called “Customer Relationship Manageme...

  12. Customs control of goods

    OpenAIRE

    Mentor Gashi; Ramadan Gashi

    2015-01-01

    Customs control, is regulated by law in different countries. Different countries define through the law, the control of goods.. Main purpose of this paper is to analyze two types of customs controls, and their effect in reducing avoidance of duty or tax evasion which may be caused by the import of goods of certain companies. For this reason we researched which model is implemented in developing countries and what results were reached through questionnaires. In this sense the next research que...

  13. Inhibition of dental plaque formation by toothpaste containing propolis

    Directory of Open Access Journals (Sweden)

    Nurin Aisyiyah Listyasari

    2012-12-01

    Full Text Available Background: Plaque is the main cause of caries and periodontal disease. Caries and periodontal disease can be prevented by inhibiting dental plaque formation. To inhibit the formation of plaque, teeth must be brushed with toothpaste. According to previous studies, propolis contains apigenin and tt-farnesol classified as flavonoid that can inhibit the formation of dental plaque by inhibiting glucosyltransferase enzym and membrane integrity of Streptococcus mutans. Purpose: The aim of this study was to determine the effect of toothpaste containing propolis on the formation of dental plaque. Methods: Post test with only control group design was used. The subjects of this study were 30 boarding school students of Hidayatullah, Yayasan Al-Burhan, Gedawang, Semarang, divided into two groups, randomized control group and treatment group. Control group was not treated with toothpaste contanining propolis. Meanwhile, treatment group was treated with toothpaste containing propolis. Plaque then was measured by using plaque index of Sillness and Loe method after using toothpaste containing propolis for four hours. Afterwards, the data was analyzed by a computer program, Mann-Whitney test, with its significance p < 0.05. Results: The result of Mann-Whitney test showed a significant difference, 0.002 (p < 0.05, between the control group and the treatment group. The median of the control group was about 3.41, while that of the treatment group was about 0.58. Conclusion: The use of toothpaste contaning propolis can prevent dental plaque formation.Latar belakang: Plak merupakan penyebab utama terjadinya karies dan penyakit periodontal. Karies dan penyakit periodontal dapat dicegah dengan menghambat pembentukan plak gigi. Untuk mencegah terbentuknya plak, gigi harus digosok menggunakan pasta gigi. Penelitian terdahulu menyebutkan bahwa propolis mengandung flavonoid apigenin dan tt-farnesol yang mampu menghambat aktivitas enzim glukosiltransferase dan menghambat

  14. Customer satisfaction measurement

    Directory of Open Access Journals (Sweden)

    Maričić Branko R.

    2012-01-01

    Full Text Available Customer satisfaction is important in business management as a basis for long-term profitability of a single line of products and services and the company as a whole. Customer satisfaction in modern market conditions is characterized by a large number of alternatives that can satisfy the same need or desire of consumers, and are a prerequisite for the retention, loyalty, and positive verbal communication between companies and vendors on one hand and consumers on the other. Companies are investing more and more investment and management efforts in improving customer satisfaction. Improving customer satisfaction and its measurement involves the taking of appropriate marketing strategies and tactics, as well as corrective measures. This paper presents the well-known attempts to measure customers' satisfaction at the macro and micro level of marketing analysis. The index of consumer satisfaction is an important indicator of achieved quality and market performance of companies and can be measured on a micro and macro level. National customer satisfaction indexes are useful framework for analyzing the competitiveness of national economies, industries and individual companies and are used for a variety of other aspects of observation and analysis. Standardization of consumer satisfaction indexes in different countries allows comparability of the data, giving a new quality of analysis in the era of globalization and internationalization of business.

  15. Customer Innovation Process Leadership

    DEFF Research Database (Denmark)

    Lindgren, Peter; Jørgensen, Jacob Høj; Goduscheit, René Chester

    2007-01-01

    Innovation leadership has traditionally been focused on leading the companies' product development fast, cost effectively and with an optimal performance driven by technological inventions or by customers´ needs. To improve the efficiency of the product development process focus has been on diffe......Innovation leadership has traditionally been focused on leading the companies' product development fast, cost effectively and with an optimal performance driven by technological inventions or by customers´ needs. To improve the efficiency of the product development process focus has been...... to handle shorter and faster product life cycles. Continuously changing customer needs are pushing companies' competence of continuous innovation to a maximum - but still this seems not to be enough to stay competitive on the global market and reach the goals of growth. This article therefore suggests...... another outlook to future innovation leadership - Customer Innovation Process Leadership - CIP-leadership. CIP-leadership moves the company's innovation process closer to the customer innovation process and discusses how companies can be involved and innovate in customers' future needs and lead...

  16. Dosimetric Calculations of a Radioactive Eye Plaque used in Management of Ocular Melanoma Using Monte Carlo Simulations

    Directory of Open Access Journals (Sweden)

    P Shokrani

    2009-10-01

    Full Text Available Introduction & Objective: Brachytherapy using I-125 radioactive seeds in removable episcleral plaques (EP is often used in treatment of ocular malignant melanoma. Some radioactive seeds are fixed in a gold bowl-shaped plaque. The plaque is sutured to the sclera surface corresponding to the base of the intraocular tumor, allowing for a localized radiation dose delivery to the tumor. Minimum target doses as high as 85Gy are directed at malignant tumor. The aim of this study was to develop a Monte Carlo simulation of an ocular plaque in order to calculate the resulting isodose distributions. Materials & Methods: The MCNP-4C Monte Carlo code is used to simulate the plan of an episcleral plaque treatment. A 20-mm Collaborative Ocular Melanoma Study (COMS plaque with 3, I-125 seed of model 6711 was used. Resulting dose distributions, including central axis dose and off-axis dose profiles, were calculated in a water phantom with 12mm radius. The calculated dose distributions were compared to the corresponding dose measured by Knuten et al., 2001. Results: Central axis dose calculations represent a rapid dose fall off, which is an important factor in selection of appropriate eye plaque for management of tumors with known dimension. Calculated off-axis dose profiles show decreased dose uniformity at distances close to the plaque. Increasing of distance from the plaque resulted in increasing of the dose uniformity. Conclusion: Monte Carlo simulation of eye plaques can be used as a useful tool in process of design, development and treatment planning of ocular radioactive plaques.

  17. The Impact of Customer-Based Brand Equity on Customer Acquisition and Customer Retention

    OpenAIRE

    F. Stahl; Heitmann, M.; Lehmann, D R

    2010-01-01

    The topic of marketing accountability is of great interest to marketing researchers and professionals. In this paper, we model the impact of customer-based brand equity on customer acquisition and customer retention which can be used as the basis for calculating customer equity. Using actual purchase data of 39 automobile brands sold in the US between 1999 and 2008 we derive customer acquisition and customer retention from first-order Markov brand-switching matrices. Brand equity is defined b...

  18. Customer Satisfaction in Internal Customer Service : Case: Abloy Oy Internal Customer Service

    OpenAIRE

    Turunen, Susanna

    2011-01-01

    ABSTRACT Turunen, Susanna Marita 2011. Customer Satisfaction in Internal Customer Service. Case: Abloy Oy Internal Customer Service. Master’s thesis. Kemi-Tornio University of Applied Sciences. Business and Culture. Pages 73. Appendix 1. This thesis discusses and studies service quality and customer satisfaction in internal customer service. The main objective is to find out what the service quality level in the internal customer service at Abloy Oy is and whether there exists a diffe...

  19. Customer Satisfaction in Internal Customer Service : Case: Abloy Oy Internal Customer Service

    OpenAIRE

    Turunen, Susanna

    2011-01-01

    ABSTRACT Turunen, Susanna Marita 2011. Customer Satisfaction in Internal Customer Service. Case: Abloy Oy Internal Customer Service. Master’s thesis. Kemi-Tornio University of Applied Sciences. Business and Culture. Pages 73. Appendix 1. This thesis discusses and studies service quality and customer satisfaction in internal customer service. The main objective is to find out what the service quality level in the internal customer service at Abloy Oy is and whether there exists a diffe...

  20. Bank Value: Comparing Customer and Employee Perceptions

    Directory of Open Access Journals (Sweden)

    Jelena Titko

    2012-06-01

    Full Text Available In the modern competitive environment, banks create the value generally using the relational capital. Thus, customer satisfaction and loyalty are the main components of bank success in a market. In turn, customer satisfaction is affected by bank service quality that determines bank’s value perceived by clients. The main goal of the research is to determine factors affecting bank value perceived by customers to examine the gaps in customers’ and employees’ perceptions of these factors. The goal of the paper is to prepare a theoretical basis for the survey and to describe and theoretically validate the design of the research instrument. To achieve the goal the brief literature review was conducted in the fields of relationship value management, service quality and customer buying behaviour. The statements of the questionnaire were developed based on Kotler’s concept of a customer perceived value and different variations of the SERVQUAL model. To purify the developed questionnaires, the authors conducted focus group interview. We believe that bank performance depends directly on the bank’s ability to capture and retain clients and on customer-employee relationships. Thus, it is crucial to know factors affecting customer perceived bank value. Using our developed instrument it is possible to measure the level of service quality in Latvian banks and to examine the difference between customers’ and employees’ viewpoints on the quality of bank services.

  1. Customer Engagement as a New Perspective in Customer Management

    NARCIS (Netherlands)

    Verhoef, Peter C.; Reinartz, Werner J.; Krafft, Manfred

    2010-01-01

    Since 2000, customer management (CM) research has evolved and has had a significant impact on the marketing discipline. In an increasingly networked society where customers can interact easily with other customers and firms through social networks and other new media, the authors propose that custom

  2. Customer Engagement as a New Perspective in Customer Management

    NARCIS (Netherlands)

    Verhoef, Peter C.; Reinartz, Werner J.; Krafft, Manfred

    2010-01-01

    Since 2000, customer management (CM) research has evolved and has had a significant impact on the marketing discipline. In an increasingly networked society where customers can interact easily with other customers and firms through social networks and other new media, the authors propose that custom

  3. Customer complaints and recovery effectiveness : A customer base approach

    NARCIS (Netherlands)

    Knox, G.; van Oest, R.D.

    2014-01-01

    Although customer complaints are a well-studied aspect of business, no study has measured the impact of actual complaints and recoveries on subsequent customer purchasing. The authors develop a customer base model to investigate the effectiveness of recovery in preventing customer churn. They calibr

  4. Customized PEC modules. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Martin B. (DTI, Taastrup (Denmark))

    2012-07-01

    The purpose of the project ''Customized PEC modules'' was to move from the production hand-made individual DSCs (dye-sensitized solar cells) in the laboratory to the production of DSC modules in a semi-automated process. At the same time allowing sufficient variation in the product's specification for real tailoring of the product to the application. The tailoring can be related to the module's electrical output and size, but also to the possibility of designing patterns for decoration or communication purposes by playing around with the shape, size and layout of the individual cells forming the module. This was to be accomplished mainly by screen printing of DSC components on glass substrates at Mekoprint. For reaching this goal the work was divided into a number of steps. The central part of the work done was in the initial conception activity and the following manufacturing activity. An activity regarding optimization included several tasks of optimization and adaptation of the existing laboratory process for manufacturing of the DSCs. Finally, work focused on international activities was done. All the steps needed for the production of customized DSC modules have been demonstrated in this project. In combination with the development of a high performing printable sealant and sealing method all the prerequisites for producing customized DSC modules have been demonstrated. (LN)

  5. Modeling of drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls to treat vulnerable plaques

    KAUST Repository

    Hossain, Shaolie S.

    2010-01-01

    The main objective of this work is to develop computational tools to support the design of a catheter-based local drug delivery system that uses nanoparticles as drug carriers in order to treat vulnerable plaques and diffuse atherosclerotic disease.

  6. Customer satisfaction toward TrueMove customer service

    OpenAIRE

    Raja Abbas, Haider; Koobgrabe, Chokaew; Chutima, Punyanuch

    2008-01-01

    Title: Customer Satisfaction toward TrueMove Customer Service Problem Statement: How are TrueMove customers satisfied with the customer service provided at TrueMove shops in Bangkok? Purpose: To evaluate “whether” and “how” TrueMove customers are satisfied or dissatisfied with the customer service provided at TrueMove shops in the Bangkok region with the help of evaluation of service quality by customers of the shop. Theory and Methods: The research bases mainly on quantitative method; that i...

  7. Effect of toothpaste on the plaque inhibitory properties of a cetylpyridinium chloride mouth rinse.

    Science.gov (United States)

    Sheen, S; Eisenburger, M; Addy, M

    2003-03-01

    Cetylpyridinium chloride (CPC) mouth rinses have moderate plaque inhibitory activity when used alone but rarely have shown adjunctive benefits to tooth brushing with toothpaste. Several explanations for this apparent anomaly can be proferred, including loss of antiseptic activity due to interactions with toothpaste ingredients. The aim of this study was to measure the effect of toothpaste on the plaque inhibitory properties of a CPC mouth rinse using paired rinses of CPC, toothpaste slurry (TP) and water (W). The study was a single blind, randomised, seven-treatment, cross over design balanced for residual effects, involving 21 healthy, dentate subjects. The paired rinses were: W-CPC, CPC-W, TP-CPC, CPC-TP, W-TP, TP-W and W-W. Rinsing with solutions or slurries was done for 60 s twice per day. On day 1, subjects were rendered plaque free, suspended tooth cleaning and commenced the allocated rinse regimen. On day 5, plaque was scored by index. A 2(1/2) day wash out of normal oral hygiene was allowed between each regimen. The order from lowest to highest plaque scores was as follows: W-CPC = CPC-W mouth rinse adversely affected the plaque inhibitory action of this antiseptic. This in part may explain the reported lack of adjunctive benefits of CPC rinses to normal oral hygiene practices and supports the suggestion, made for chlorhexidine rinses, that their use should follow toothpaste by at least 60 min.

  8. Efficacy of essential oil mouthwash with and without alcohol: a 3-Day plaque accumulation model

    Directory of Open Access Journals (Sweden)

    Marchetti Enrico

    2011-12-01

    Full Text Available Abstract Background The aim of this study was to evaluate the antiplaque effect of a new alcohol free essential oil mouthwash with respect to a control of an essential oil with alcohol mouthwash, using an in vivo plaque regrowth model of 3-days. Methods The study was designed as a double-masked, randomized, crossover clinical trial, involving 30 volunteers to compare two different essential oil containing mouthwashes, during a 3-day plaque accumulation model. After receiving a thorough professional prophylaxis at the baseline, over the next 3-days each volunteer refrained from all oral hygiene measures and had two daily rinses with 20 ml of the test mouthwash (alcohol free essential oil or the control mouthwash (essential oil with alcohol. At the end of the each experimental period, plaque was assessed and the panelists filled out a questionnaire. Each subject underwent a 14 days washout period and there was a second allocation. Results The essential oil mouthwash with ethanol shows a better inhibitory effect of plaque regrowth in 3-days than the mouthwash test with only essential oil in the whole mouth (plaque index = 2.18 against 2.46, respectively, p Conclusion The essential oil containing mouthwash without alcohol seems to have a less inhibiting effect on the plaque regrowth than the traditional alcoholic solution. Trial Registration ClinicalTrials.gov NCT01411618

  9. A data-driven framework for investigating customer retention

    OpenAIRE

    Mgbemena, Chidozie Simon

    2016-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University London. This study presents a data-driven simulation framework in order to understand customer behaviour and therefore improve customer retention. The overarching system design methodology used for this study is aligned with the design science paradigm. The Social Media Domain Analysis (SoMeDoA) approach is adopted and evaluated to build a model on the determinants of customer satisfaction ...

  10. 3D Tissue Scaffold Printing On Custom Artificial Bone Applications

    OpenAIRE

    Betül ALDEMİR; DİKİCİ, Serkan; ÖZTÜRK, Şükrü; KAHRAMAN, Ozan; Aylin ŞENDEMİR ÜRKMEZ; Oflaz, Hakan, 1980-

    2015-01-01

    Production of defect-matching scaffolds is the most critical step in custom artificial bone applications. Three dimensional printing (3DP) is one of the best techniques particularly for custom designs on artificial bone applications because of the high controllability and design independency. Our long-term aim is to implant an artificial custom bone that is cultured with patient's own mesenchymal stem cells after determining defect architecture on patient's bone by using CT-scan and printing ...

  11. Plaque control evaluation of a stabilized stannous fluoride dentifrice compared to a triclosan dentifrice in a six-week trial.

    Science.gov (United States)

    Sharma, N; He, T; Barker, M L; Biesbrock, A R

    2013-01-01

    To compare the anti-plaque efficacy of a stabilized 0.454% stannous fluoride (referred to as SnF2) dentifrice versus a 0.3% triclosan dentifrice formulated with a copolymer and sodium fluoride (referred to as triclosan). The study had a randomized, double-blind, two-treatment, parallel-group design, and compared plaque reduction from baseline after both three and six weeks of treatment with either the SnF2 or triclosan dentifrices using a manual toothbrush. Subjects brushed their teeth using their assigned treatment dentifrices according to the manufacturer's instructions. Following overnight plaque accumulation, levels of plaque were assessed by an experienced examiner using the Rustogi, et al. Modified Navy Plaque Index at the start of the study (baseline), and after three and six weeks of regular brushing. Groups were compared using analysis of covariance separately for Weeks 3 and 6, and by repeated measures for Weeks 3 and 6 combined. One-hundred and twenty subjects were randomized to treatment and 114 subjects completed the study. Both treatment groups showed a statistically significant reduction from baseline in mean plaque values for all three tooth areas (whole mouth, gingival margin, interproximal) at both Weeks 3 and 6 (p dentifrices showed statistically significant reductions from baseline in whole mouth, gumline, and interproximal accumulated overnight plaque after three and six weeks of brushing, but the SnF2 dentifrice showed statistically significantly greater plaque reductions versus the triclosan dentifrice.

  12. Design and Implemetation of Online Customs Agent Management System Based on Workflow%基于工作流的在线代理报关管理系统设计与实现

    Institute of Scientific and Technical Information of China (English)

    周文琼; 王乐球; 郑述招

    2013-01-01

    随着计算机技术的不断发展和互联网的普遍应用,代理报关企业迫切需要实施管理信息系统,以对内建立企业内控机制,对外提高客户服务质量.本文基于工作流技术,阐述在线代理报关管理系统的设计与实现,重点描述系统各个功能模块、系统流程、系统运行环境、系统数据库设计.该系统在某港口报关行已实施,取得了良好效果,与同类其他系统比较,该系统具有更安全、更稳定、更易扩展、更易维护之优点.%With the continuous development of computer technology and the popularity of Internet application,in order to establish internal control mechanisms and improve the quality of customer service externally,this paper describes the design and implementation of online customs agent management system based on Workflow technology,focusing on the various functional modules of the system description,system processes,system operating environment,system database design.The system has been implemented on a port customs broker,compared with similar other systems,the system is safer,more stable,easier to expand and easier to maintain.

  13. DECT evaluation of noncalcified coronary artery plaque

    Energy Technology Data Exchange (ETDEWEB)

    Ravanfar Haghighi, Rezvan [Medical Imaging Research Center and Colorectal Research Center, Shiraz University of Medical Science, Shiraz 719 363 5899 (Iran, Islamic Republic of); Chatterjee, S. [BGVS Chemical Engineering Building (Old), Indian Institute of Science, Bangalore 560012 (India); Tabin, Milo; Singh, Rishi P.; Sharma, Munish; Krishna, Karthik [Department of Forensic Medicine, All India Institute of Medical Sciences, New Delhi 110029 (India); Sharma, Sanjiv; Jagia, Priya [Department of Cardiac-Radiology, All India Institute of Medical Sciences, New Delhi 110029 (India); Ray, Ruma; Arava, Sudhir [Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029 (India); Yadav, Rakesh [Department of Cardiology, All India Institute of Medical Sciences, New Delhi 110029 (India); Vani, V. C. [Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore 560012 (India); Lakshmi, R.; Kumar, Pratik, E-mail: drpratikkumar@gmail.com [Department of Cardiac-Biochemistry, All India Institute of Medical Sciences, New Delhi 110029 (India); Mandal, Susama R. [Department of Medical Physics Unit IRCH, All India Institute of Medical Sciences, New Delhi 110029 (India)

    2015-10-15

    Purpose: Composition of the coronary artery plaque is known to have critical role in heart attack. While calcified plaque can easily be diagnosed by conventional CT, it fails to distinguish between fibrous and lipid rich plaques. In the present paper, the authors discuss the experimental techniques and obtain a numerical algorithm by which the electron density (ρ{sub e}) and the effective atomic number (Z{sub eff}) can be obtained from the dual energy computed tomography (DECT) data. The idea is to use this inversion method to characterize and distinguish between the lipid and fibrous coronary artery plaques. Methods: For the purpose of calibration of the CT machine, the authors prepare aqueous samples whose calculated values of (ρ{sub e}, Z{sub eff}) lie in the range of (2.65 × 10{sup 23} ≤ ρ{sub e} ≤ 3.64 × 10{sup 23}/cm{sup 3}) and (6.80 ≤ Z{sub eff} ≤ 8.90). The authors fill the phantom with these known samples and experimentally determine HU(V{sub 1}) and HU(V{sub 2}), with V{sub 1},V{sub 2} = 100 and 140 kVp, for the same pixels and thus determine the coefficients of inversion that allow us to determine (ρ{sub e}, Z{sub eff}) from the DECT data. The HU(100) and HU(140) for the coronary artery plaque are obtained by filling the channel of the coronary artery with a viscous solution of methyl cellulose in water, containing 2% contrast. These (ρ{sub e}, Z{sub eff}) values of the coronary artery plaque are used for their characterization on the basis of theoretical models of atomic compositions of the plaque materials. These results are compared with histopathological report. Results: The authors find that the calibration gives ρ{sub e} with an accuracy of ±3.5% while Z{sub eff} is found within ±1% of the actual value, the confidence being 95%. The HU(100) and HU(140) are found to be considerably different for the same plaque at the same position and there is a linear trend between these two HU values. It is noted that pure lipid type plaques

  14. Assessment of Customers' Level of Interest

    NARCIS (Netherlands)

    Popa, M.C.; Rothkrantz, L.J.M.; Shan, C.; Wiggers, P.

    2012-01-01

    Surveillance systems in shopping malls or supermarkets are usually designated for assuring safety and detecting abnormal behavior. We used the distributed video cameras system to design digital shopping assistants which assess the behavior of customers while shopping, detect when they need assistanc

  15. Smart customers, dumb companies.

    Science.gov (United States)

    Locke, C

    2000-01-01

    Customers today are being bombarded with an overwhelming array of choices. To alleviate customer frustration, say Steven Cristol and Peter Sealey in Simplicity Marketing, companies should stop creating new brands and product extensions. Better to consolidate product and service functions by following a four R approach: replace, repackage, reposition, and replenish. That's an outmoded, dictatorial view of markets, says Christopher Locke. Far from being stymied by choices, customers are rapidly becoming smarter than the companies that pretend to serve them. In this networked economy, people are talking among themselves, and that changes everything. Locke predicts we'll see a growing number of well-defined micromarkets--groups of customers converging in real time around entertaining and knowledgeable voices--such as NPR's car guys and the Motley Fool investment site. "Micromedia" Web sites will replace traditional advertising because they'll provide credible user-supplied news about products and services. Locke contends that an open exchange of information solves the "problem" of choice much better than manipulative strategies like simplicity or even permission marketing. Companies can participate in micromarkets through what Locke dubs "gonzo marketing." If Ford, for example, discovers that a subset of its employees are organic gardeners, it may offer support to a big independent organic-gardening Web site with donations and employee volunteers. This marketing effort would be driven not by advertising managers but by people with genuine interest in each micromarket, so it would have credibility with customers. With gonzo marketing, both companies and their markets will benefit.

  16. Relationship between caries and dental plaque composition.

    Science.gov (United States)

    Bayrak, Sule; Okte, Zeynep; Fidanci, Ulvi Reha

    2011-02-01

    To evaluate the relationship between dental caries and the biochemical composition of dental plaque and to determine the effect of a 10% sucrose solution on the biochemical structure of dental plaque in children. 60 children grouped according to caries status took part in this study [Caries-free (CF), DMFS=0, df-s = 0; Caries-positive (CP), DMFS > or =10, df-s > or =10]. Dental plaque samples were collected before (baseline) and at 3 and 30 minutes after a 1-minute rinse with 10% sucrose. Fluoride (F), calcium (Ca), and inorganic phosphorus (Pi) levels were determined using ion chromatography, and insoluble polysaccharide (IEPS) concentrations were determined using colorimetric analysis. Although the mean baseline Ca and Pi levels in plaque were higher in the CF group than in the CP group, these differences were not statistically significant. Baseline IEPS levels were significantly higher in the CP group than in the CF group. Following exposure to sucrose, plaque F, Ca and Pi concentrations decreased significantly in both groups. However, insoluble polysaccharide concentrations increased significantly in the CF group only.

  17. Functional expression of dental plaque microbiota.

    Science.gov (United States)

    Peterson, Scott N; Meissner, Tobias; Su, Andrew I; Snesrud, Erik; Ong, Ana C; Schork, Nicholas J; Bretz, Walter A

    2014-01-01

    Dental caries remains a significant public health problem and is considered pandemic worldwide. The prediction of dental caries based on profiling of microbial species involved in disease and equally important, the identification of species conferring dental health has proven more difficult than anticipated due to high interpersonal and geographical variability of dental plaque microbiota. We have used RNA-Seq to perform global gene expression analysis of dental plaque microbiota derived from 19 twin pairs that were either concordant (caries-active or caries-free) or discordant for dental caries. The transcription profiling allowed us to define a functional core microbiota consisting of nearly 60 species. Similarities in gene expression patterns allowed a preliminary assessment of the relative contribution of human genetics, environmental factors and caries phenotype on the microbiota's transcriptome. Correlation analysis of transcription allowed the identification of numerous functional networks, suggesting that inter-personal environmental variables may co-select for groups of genera and species. Analysis of functional role categories allowed the identification of dominant functions expressed by dental plaque biofilm communities, that highlight the biochemical priorities of dental plaque microbes to metabolize diverse sugars and cope with the acid and oxidative stress resulting from sugar fermentation. The wealth of data generated by deep sequencing of expressed transcripts enables a greatly expanded perspective concerning the functional expression of dental plaque microbiota.

  18. Fatigue crack propagation analysis of plaque rupture.

    Science.gov (United States)

    Pei, Xuan; Wu, Baijian; Li, Zhi-Yong

    2013-10-01

    Rupture of atheromatous plaque is the major cause of stroke or heart attack. Considering that the cardiovascular system is a classic fatigue environment, plaque rupture was treated as a chronic fatigue crack growth process in this study. Fracture mechanics theory was introduced to describe the stress status at the crack tip and Paris' law was used to calculate the crack growth rate. The effect of anatomical variation of an idealized plaque cross-section model was investigated. The crack initiation was considered to be either at the maximum circumferential stress location or at any other possible locations around the lumen. Although the crack automatically initialized at the maximum circumferential stress location usually propagated faster than others, it was not necessarily the most critical location where the fatigue life reached its minimum. We found that the fatigue life was minimum for cracks initialized in the following three regions: the midcap zone, the shoulder zone, and the backside zone. The anatomical variation has a significant influence on the fatigue life. Either a decrease in cap thickness or an increase in lipid pool size resulted in a significant decrease in fatigue life. Comparing to the previously used stress analysis, this fatigue model provides some possible explanations of plaque rupture at a low stress level in a pulsatile cardiovascular environment, and the method proposed here may be useful for further investigation of the mechanism of plaque rupture based on in vivo patient data.

  19. Functional Expression of Dental Plaque Microbiota

    Directory of Open Access Journals (Sweden)

    Scott Norman Peterson

    2014-08-01

    Full Text Available Dental caries remains a significant public health problem and is considered pandemic worldwide. The prediction of dental caries based on profiling of microbial species involved in disease and equally important, the identification of species conferring dental health has proven more difficult than anticipated due to high interpersonal and geographical variability of dental plaque microbiota. We have used RNA-Seq to perform global gene expression analysis of dental plaque microbiota derived from 19 twin pairs that were either concordant (caries-active or caries-free or discordant for dental caries. The transcription profiling allowed us to define a functional core microbiota consisting of nearly 60 species. Similarities in gene expression patterns allowed a preliminary assessment of the relative contribution of human genetics, environmental factors and caries phenotype on the microbiota’s transcriptome. Correlation analysis of transcription allowed the identification of numerous functional networks, suggesting that inter-personal environmental variables may co-select for groups of genera and species. Analysis of functional role categories allowed the identification of dominant functions expressed by dental plaque biofilm communities, that highlight the biochemical priorities of dental plaque microbes to metabolize diverse sugars and cope with the acid and oxidative stress resulting from sugar fermentation. The wealth of data generated by deep sequencing of expressed transcripts enables a greatly expanded perspective concerning the functional expression of dental plaque microbiota.

  20. Design and finite element analysis of custom-made, root-analogue implant%个性化拟自然牙种植体的设计及有限元分析

    Institute of Scientific and Technical Information of China (English)

    高亦林; 游嘉; 彭伟; 周见; 田明飞

    2015-01-01

    目的:设计和制造面向即刻种植的个性化拟自然牙种植体,并提出个性化拟自然牙种植体的过盈量设计要求。方法:利用逆向工程和3D 打印技术设计和制造出个性化拟自然牙种植体;设计过盈量分别为10,20,30,40,50,60,70,80,90,100μm的10颗个性化拟自然牙种植体,模拟植入相同拔牙窝后的情况,并进行有限元分析。结果:在相同的过盈量条件下,皮质骨区域比松质骨区域的应力值要大。随着过盈量的增大,种植体在骨界面的应力就越大,且皮质骨区域比松质骨区域先达到屈服强度。结论:在设计个性化拟自然牙根种植体的过程中,皮质骨和松质骨区域的过盈量设计应当不同,且皮质骨区域应小于松质骨区域。%Objective: To design a kind of custom-made, root-analogue implant for immediate implant placement. Propose the design requirements of the interference of the implant by finite element analysis. Methods: Design and manufacture the implant with the help of RE and 3D printing technology. Design 10 custom-made, root-analogue implants with the interference of 10, 20, 30, 40, 50, 60, 70, 80, 90, 100μm respectively. Simulate the implantation with the same extraction socket by finite element analysis. Results: Under the same condition, stress of cortical bone area is larger than cancellous bone area. With the increasing amount of interference, the greater the stress of implant-bone interface and cortical bone area reach the yield strength first. Conclusions: In the process of designing a custom-made root-analogue implant, the amount of interference of cortical and cancellous bone area should be designed differently. And the amount of interference of cortical bone area should be less than cancellous bone area's.

  1. Customer/User Workshops in Product development

    DEFF Research Database (Denmark)

    Brandt, Eva; Binder, Thomas

    1997-01-01

    In a recent product development project, we have taken part in establishing and organising a series of workshops with a group of customers/users of a future product line through out the development project. The workshops is a kind of informal meetingplace for engineering, marketing, customers......, and users where different needs, preferences, and interests can be discussed. Bringing together stakeholders with different experiences and competencies can provide a highly innovative setting if we are succesful in establishing common understandings of the development task.In this paper we present...... and discuss experiences with this kind of collaborative fora. We have tried to demonstrate that having an on-going dialogue with users/customers also during detailed design in not only a means to keep 'the voive of the customer alive'. We have found that the workshops have an important impact on securing...

  2. Emotional Satisfaction of Customer Contacts

    NARCIS (Netherlands)

    Güngör, Hüseyin

    2007-01-01

    For marketing and customer services researchers and professionals who are interested in customer contacts, customer satisfaction and loyalty issues. Contact centers are playing a pivotal role in customer services of the 21st century. Nevertheless, despite their growing importance and presence, conta

  3. Emotional Satisfaction of Customer Contacts

    NARCIS (Netherlands)

    Güngör, Hüseyin

    2007-01-01

    For marketing and customer services researchers and professionals who are interested in customer contacts, customer satisfaction and loyalty issues. Contact centers are playing a pivotal role in customer services of the 21st century. Nevertheless, despite their growing importance and presence,

  4. Emotional Satisfaction of Customer Contacts

    NARCIS (Netherlands)

    Güngör, Hüseyin

    2007-01-01

    For marketing and customer services researchers and professionals who are interested in customer contacts, customer satisfaction and loyalty issues. Contact centers are playing a pivotal role in customer services of the 21st century. Nevertheless, despite their growing importance and presence, conta

  5. Consumer Preferences for Mass Customization

    NARCIS (Netherlands)

    B.G.C. Dellaert (Benedict); S. Stremersch (Stefan)

    2004-01-01

    textabstractIncreasingly, firms adopt mass customization, which allows consumers to customize products by self-selecting their most preferred composition of the product for a predefined set of modules. For example, PC vendors such as Dell allow customers to customize their PC by choosing the type of

  6. Consumer Preferences for Mass Customization

    NARCIS (Netherlands)

    B.G.C. Dellaert (Benedict); S. Stremersch (Stefan)

    2004-01-01

    textabstractIncreasingly, firms adopt mass customization, which allows consumers to customize products by self-selecting their most preferred composition of the product for a predefined set of modules. For example, PC vendors such as Dell allow customers to customize their PC by choosing the type of

  7. The effect of customer relationship management on customer loyalty: Evidence from banking industry

    Directory of Open Access Journals (Sweden)

    Hadi Hajiyan

    2015-11-01

    Full Text Available Measuring customer satisfaction in banking industry plays essential role for increasing market share and profitability. In this paper, we present an empirical investigation to measure the effect of customer relationship management (CRM on customer loyalty in Iranian banking industry. The study aims to understand whether implementation of a good CRM could increase the quality of services. The study designs a questionnaire in Likert scale and distributes it among 65 selected customers who do their banking activities with Bank Melli Iran in city of Semnan, Iran. Cronbach alpha has been calculated as 0.939, which is well above desirable level. Using t-student test, the study has determined that implementation of CRM could increase customer loyalty and quality of services.

  8. First results for custom-built low-temperature (4.2 K) scanning tunneling microscope/molecular beam epitaxy and pulsed laser epitaxy system designed for spin-polarized measurements

    Science.gov (United States)

    Foley, Andrew; Alam, Khan; Lin, Wenzhi; Wang, Kangkang; Chinchore, Abhijit; Corbett, Joseph; Savage, Alan; Chen, Tianjiao; Shi, Meng; Pak, Jeongihm; Smith, Arthur

    2014-03-01

    A custom low-temperature (4.2 K) scanning tunneling microscope system has been developed which is combined directly with a custom molecular beam epitaxy facility (and also including pulsed laser epitaxy) for the purpose of studying surface nanomagnetism of complex spintronic materials down to the atomic scale. For purposes of carrying out spin-polarized STM measurements, the microscope is built into a split-coil, 4.5 Tesla superconducting magnet system where the magnetic field can be applied normal to the sample surface; since, as a result, the microscope does not include eddy current damping, vibration isolation is achieved using a unique combination of two stages of pneumatic isolators along with an acoustical noise shield, in addition to the use of a highly stable as well as modular `Pan'-style STM design with a high Q factor. First 4.2 K results reveal, with clear atomic resolution, various reconstructions on wurtzite GaN c-plane surfaces grown by MBE, including the c(6x12) on N-polar GaN(0001). Details of the system design and functionality will be presented.

  9. Encounters with immigrant customers

    DEFF Research Database (Denmark)

    Mygind, Anna; Espersen, Sacha; Nørgaard, Lotte Stig

    2013-01-01

    OBJECTIVES: To explore the challenges that Danish community pharmacy staff encounter when serving non-Western immigrant customers. Special attention was paid to similarities and differences between the perceptions of pharmacists and pharmacy assistants. METHODS: A questionnaire was distributed...... to one pharmacist and one pharmacy assistant employed at each of the 55 community pharmacies located in the five local councils in Denmark with the highest number of immigrant inhabitants. KEY FINDINGS: The total response rate was 76% (84/110). Most respondents found that the needs of immigrant customers...... companies. CONCLUSIONS: Community pharmacy staff report poorer quality in their encounters with immigrant customers, including sub-optimal counselling and frequent use of under-aged children as interpreters. Our study also reveals certain differences across personnel groups, which may be explained...

  10. Customer Preference-Based Information Retrieval to Build Module Concepts

    Directory of Open Access Journals (Sweden)

    Dongxing Cao

    2013-01-01

    Full Text Available Preference is viewed as an outer feeling of a product, also as a reflection of human's inner thought. It dominates the designers' decisions and affects our purchase intention. In the paper, a model of preference elicitation from customers is proposed to build module concepts. Firstly, the attributes of customer preference are classified in a hierarchy and make the surveys to build customer preference concepts. Secondly, the documents or catalogs of design requirements, perhaps containing some textual description and geometric data, are normalized by using semantic expressions. Some semantic rules are developed to describe low-level features of customer preference to construct a knowledge base of customer preference. Thirdly, designers' needs are used to map customer preference for generating module concepts. Finally, an empirical study of the stapler is surveyed to illustrate the validity of module concept generation.

  11. Non-plaque-induced gingival lesions

    DEFF Research Database (Denmark)

    Holmstrup, P

    1999-01-01

    The origin of gingival inflammation is occasionally different from that of routine plaque-associated gingivitis, and such non-plaque-associated types of gingivitis often present characteristic clinical features. Examples of such forms of gingivitis are specific bacterial, viral, and fungal......, a confirmed diagnosis may require histopathologic examination and/or culture. Atypical gingivitis may also occur as gingival manifestations of dermatological diseases, the most relevant of these being lichen planus, pemphigoid, pemphigus vulgaris, erythema multiforme, and lupus erythematosus. Non-plaque......, the most important of these being Candida species including C. albicans, C. glabrata, C. krusei, C. tropicalis, C. parapsilosis, and C. guillermondii. Gingival histoplasmosis is a granulomatous disease caused by the fungus Histoplasma capsulatum and, as for the other specific infections of gingiva...

  12. Plaque rupture in humans and mice

    DEFF Research Database (Denmark)

    Schwartz, Stephen M; Galis, Zorina S; Rosenfeld, Michael E

    2007-01-01

    Despite the many studies of murine atherosclerosis, we do not yet know the relevance of the natural history of this model to the final events precipitated by plaque disruption of human atherosclerotic lesions. The literature has become particularly confused because of the common use of terms...... such as "instability", "vulnerable", "rupture", or even "thrombosis" for features of plaques in murine model systems not yet shown to rupture spontaneously and in an animal surprisingly resistant to formation of thrombi at sites of atherosclerosis. We suggest that use of conclusory terms like "vulnerable" and "stable...... that various forms of data have implicated in plaque progression. For example, formation of the fibrous cap, protease activation, and cell death in the necrotic core can be well described and have all been modeled in well-defined experiments. The relevance of such well-defined, objective, descriptive...

  13. 19 CFR 127.14 - Disposition of merchandise in Customs custody beyond time fixed by law.

    Science.gov (United States)

    2010-04-01

    ... an electronic equivalent as authorized by Customs. (ii) Notice of destruction. Before destroying the... as designated by the port director or an electronic equivalent as authorized by Customs, at least 30... 19 Customs Duties 1 2010-04-01 2010-04-01 false Disposition of merchandise in Customs...

  14. Take Five for Customer Service

    OpenAIRE

    Laura J. Ax-Fultz; Barbara E. Eshbach; Evonne N. Loomis; Miller, Richard C.

    2016-01-01

    Businesses leverage excellent customer service to improve profitability. Although not profit-driven, libraries should leverage excellent customer service to achieve their unique missions. Evaluating and improving customer service practices will help a library determine if it is successfully serving its customers. The library should review three areas to improve customer service: the physical space of the library, how library employees work with library policies, and the communication skills o...

  15. Customer Satisfaction in Hotel Services

    OpenAIRE

    Bizi Mubiri, Joleen

    2016-01-01

    The purpose of this thesis was to investigate how customer satisfaction enhances customer loyalty in hotels. Specifically, the thesis used Lake Kivu Serena Hotel as a case study. Customer retention is achieved by involving customers in improving the quality of services offered by a hotel. Moreover, customers feel appreciated when they realize that the hotel is committed to improving their experience. Qualitative and quantitative methods of research were used to collect the data for the re-...

  16. TOTAL QUALITY CUSTOMER SATISFACTION MODEL

    OpenAIRE

    Jesús Cruz Álvarez; Jesús Fabián López; Carlos Monge Perry

    2014-01-01

    In today’s business environment, all organizations are required to focus on their customers in order to fully understand their needs. There is a need to drive and engage strategic actions in order to close any potentials gaps between customer´s expectations and manufacture´s deliverables. Current customer satisfaction theory appears to be excluded from a holistic model that broadly covers the extent of customer satisfaction concept.This article empathizes the need of an integrated customer sa...

  17. PORPHYROMONAS GINGIVALIS IN CORONARY ATHEROMA AND SUBGINGIVAL PLAQUE – A CLINICAL AND MICROBIOLOGICAL STUDY

    Directory of Open Access Journals (Sweden)

    Col S K

    2014-01-01

    Full Text Available BACKGROUND : There has been increasing attention paid in recent years to the possibility that oral bacterial infection, particularly periodontal disease may influence the initiation and or progression of systemic diseases. These studies confirm the observation that hea rt disease is the most commonly found systemic condition in patients with periodontal disease. Moreover, the literature has also highlighted substantial evidence indicating the presence of gram negative periodontal pathogens in atheromatous plaques. AIMS : The present study intends to investigate the possible association between periodontal health and coronary artery disease by evaluating periodontal status, association between the periodontal plaque and coronary atheromatous plaques for presence of P.ging ivalis. SETTINGS AND DESIGN : A case control study was designed with 07 patients who had underwent coronary endarterectomy for CVD and 28 controls . The periodontal examination for cases was performed one day before vascular surgery and t he controls we re clinically examined. METHODS AND MATERIAL : The atheromatous plaque sample collected during endarterectomy and the Intraoral plaque samples were subjected to PCR for identification of P.gingivalis. The presence of periodontal bacteria DNA in coronary atheromatous plaques and subgingival plaque samples of the same patients was confirmed by this study. STATISTICAL ANALYSIS USED : Means and proportions for personal characters, major risk factors and c linical parameters were calculated for both the groups. The significance of any difference in means was tested by using “Students t test”, and the significance of any difference in proportions was tested by using Dunn - Sidak Adjusted p Value. RESULTS : D uring the microbial analysis of plaque samples by PCR in group A it was seen that Porphyromonas gingivalis in 100 % of the samples . Microbial analysis of endarterectomy samples by PCR in group A shows that Porphyromonas

  18. Cobalt60 plaques in recurrent retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Fass, D.; McCormick, B.; Abramson, D.; Ellsworth, R. (Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, NY, NY (USA))

    1991-08-01

    Cobalt60 plaque irradiation is one treatment option for patients with recurrent retinoblastoma following conventional external beam irradiation (ERT). Tumorocidal doses can be delivered without excessive risk of normal tissue injury. In patients not considered candidates for xenon arc or cryotherapy, 60Co is an alternative to enucleation. Between 1968 and 1987, 85 patients were treated with 60Co plaques, 72 of whom had failed prior ERT. Age at diagnosis ranged from 1 week to 4 years. There are 37 males and 35 females. Seventy-one patients had bilateral disease and one had unilateral. Three patients had both eyes plaqued. Prior ERT ranged from 30 to 70 Gy (mean 4200 Gy). Time from initial therapy to failure ranged from 13 to 60 months. Cobalt plaques of 10 mm, 15 mm, or 10 {times} 15 mm were used depending on tumor size and location. Dose prescribed to the apex of the tumor ranged from 30 to 50 Gy (median 40 Gy) given over 3 to 8 days. Twelve patients had two plaque applications; three patients had three plaque applications. All patients were followed with routine ophthalmoscopic examinations. Follow-up ranged from 2 to 22 years (mean 8.7). Seven patients died of metastatic disease; 10 patients developed non-ocular second tumors. Thirty patients required enucleation. Twenty-two patients had clear tumor progression, two patients had radiation complications, and six patients had a combination of tumor growth and complications. Cobalt60 can salvage eyes in retinoblastoma patients failing ERT. Currently, the authors are using I125 in an attempt to spare normal ocular tissue and reduce subsequent complications.

  19. The impact of customer-specific marketing expenses on customer retention and customer profitability

    NARCIS (Netherlands)

    van Triest, S.; Bun, M.J.G.; van Raaij, E.M.; Vernooij, M.J.A.

    2009-01-01

    We study the effects of customer-specific marketing expenses on customer retention and customer profitability in a business-to-business setting. Using data from a company providing hygiene services, we look at the impact of a hitherto unstudied type of expense targeted at individual customer relatio

  20. The impact of customer-specific marketing expenses on customer retention and customer profitability

    NARCIS (Netherlands)

    van Triest, S.; van Raaij, E.M.; Bun, M.; Vernooij, M.

    2007-01-01

    We study the effects of customer-specific marketing expenses on customer retention and cus-tomer profitability in a business-to-business setting. Using data from a company providing hygiene services, we look at the impact of a type of expenses targeted at individual customer relationships: the offer

  1. Analysis of Customer Loyalty through Total Quality Service, Customer Relationship Management and Customer Satisfaction

    Science.gov (United States)

    Binsar Kristian P., Feliks Anggia; Panjaitan, Hotman

    2014-01-01

    This research talks about total quality service and customer relationship management effects toward customer satisfaction and its impact on customer loyalty. Fast food restaurant KFC, always strives to continue to make improvements in total quality service, so that customer satisfaction can be maintained, which in turn will have an impact on…

  2. 酒店管理信息系统中顾客满意支持系统的设计%Design of Customer Satisfaction Support System of Hotel Management Information System

    Institute of Scientific and Technical Information of China (English)

    杜艳萍; 长青; 薛亚茹

    2016-01-01

    The traditional hotel customer satisfaction questionnaire investigation method exists the practical problem of time-lag,high cost and low efficiency of feedback. Based on ACSI ( American Customer Satisfaction Index) model,the evaluation indexes system of custom-er satisfaction in hotel is designed. The principle of entropy weight method and FCE ( Fuzzy Comprehensive Evaluation) confirm the weight of each factor and customers’ general satisfaction. The multi-factor contribution model ( IPA) is applied to confirm the factors need to improve and keep in hotel. At last,using techniques and methods of system,the customer satisfaction management system is de-signed and implemented. The system can analyze customer feedback timely,determine the importance of the various factors affecting the weight dynamically,defining their status in IPA model quickly,and improving service quality to provide advice and reference for hotel managers timely. It makes a valuable reference to improve the service quality of the hotel.%传统的问卷式酒店顾客满意调查方法在实用中存在时滞性、成本高、反馈效率低、整理分析困难等诸多问题。基于美国满意度指数( ACSI)模型,设计了酒店顾客满意度测评体系,通过熵权法和模糊综合评价法确定各影响因素的重要性权重并计算出各因素的实际满意度和总体满意程度;运用多因素贡献模型( IPA模型),有效确定酒店服务中需要改进与保持的服务因素,最后用系统开发技术对酒店管理信息系统中顾客满意支持系统进行了设计和实现。该系统可随时调整问卷中影响酒店服务的因素,及时分析新加入因素的影响;可以及时快速地分析顾客的测评结果和反馈意见,动态确定各个影响因素的重要性权重,快速地界定其在IPA模型中的状态,为酒店管理者及时改进酒店的服务质量提供意见和参考。

  3. A study on reliability of power customer in distribution network

    Science.gov (United States)

    Liu, Liyuan; Ouyang, Sen; Chen, Danling; Ma, Shaohua; Wang, Xin

    2017-05-01

    The existing power supply reliability index system is oriented to power system without considering actual electricity availability in customer side. In addition, it is unable to reflect outage or customer’s equipment shutdown caused by instantaneous interruption and power quality problem. This paper thus makes a systematic study on reliability of power customer. By comparing with power supply reliability, reliability of power customer is defined and extracted its evaluation requirements. An indexes system, consisting of seven customer indexes and two contrast indexes, are designed to describe reliability of power customer from continuity and availability. In order to comprehensively and quantitatively evaluate reliability of power customer in distribution networks, reliability evaluation method is proposed based on improved entropy method and the punishment weighting principle. Practical application has proved that reliability index system and evaluation method for power customer is reasonable and effective.

  4. Improving Customer Satisfaction in an R and D Environment

    Science.gov (United States)

    Alexander, Anita; Liou, Y. H. Andrew

    1998-01-01

    Satisfying customer needs is critical to the sustained competitive advantage of service suppliers. It is therefore important to understand the types of customer needs which, if fulfilled or exceeded, add value and contribute to overall customer satisfaction. This study identifies the needs of various research and development (R&D) customers who contract for engineering and design support services. The Quality Function Deployment (QFD) process was used to organize and translate each customer need into performance measures that, if implemented, can improve customer satisfaction. This study also provides specific performance measures that will more accurately guide the efforts of the engineering supplier. These organizations can either implement the QFD methodology presented herein or extract a few performance measures that are specific to the quality dimensions in need of improvement. Listening to 'what' customers talk about is a good first start.

  5. Achieving Customer Satisfaction through Integrated Products and Services

    DEFF Research Database (Denmark)

    Raja, Jawwad; Bourne, Dorota; Goffin, Keith

    2013-01-01

    Complex products such as manufacturing equipment have always needed maintenance and repair services. Increasingly, leading manufacturers are integrating products and services to generate increased revenues and achieve customer satisfaction. Designing integrated products and services requires...... a different approach to new product development and a clear understanding of how customers perceive the value they obtain from actual usage of products and services—so-called value-in-use. However, there is a lack of research on integrated products and services and how they impact customer satisfaction...... of value-in-use on customer satisfaction. Two key attributes—relational dynamic and access—were found to have the most influence on customer satisfaction. This paper contributes to the innovation field by identifying customer needs for integrated products and services and how these impact customer...

  6. Design and implementation of bank customer identification system based on data warehouse%基于DW的银行客户识别系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    李旭荣; 田小东

    2012-01-01

    In order to recognize bank customers and provide the customers with different and personalized service, the original customer identification method of ICBC was improved, based on the total property identification method for individual costomers, and relying on the enterprise-level data warehouse (DW) available in Head Office of ICBC. A provincial branch bank data mart system architecture which has two levels and three layers was designed) and the model of data mart, data extracting/transforming loading (ETL) and front-end report were implemented. It solves the problem that the old system can't extract, transform and load data from different data sources. The system meets the business requirements of ICBC.%为了识别银行客户并对客户提供差异化、个性化服务,依托工商银行总行现有的企业级数据仓库,在银行个人客户总资产识别方法的基础上对工商银行的客户识别方法进行了改进.提出了新的客户识别方法,设计了省分行数据集市“两级、三层”的系统架构,并实现了数据集市模型、ETL和前端展现,解决了以往不能对不同数据源的数据进行抽取、转换、装载等操作,满足了银行业务部门的需要.

  7. Plaque growth-inhibiting effects of an abrasive fluoride-chlorhexidine toothpaste and a fluoride toothpaste containing oxidative enzymes.

    Science.gov (United States)

    Etemadzadeh, H; Ainamo, J; Murtomaa, H

    1985-08-01

    The aim of this 4 times cross-over double-blind clinical trial was to test the plaque-inhibiting effect of 2 fluoride-containing toothpastes. One toothpaste contained 0.8% chlorhexidine together with amine fluoride (0.1% F degrees) and a suitable abrasive agent. The other contained 1.7 U/g glucose oxidase and 8.0 U/g amyloglucosidase, added to an amine fluoride (0.1% F degrees) toothpaste. 1% Hibitane dental gel was used as a positive and a conventional fluoride toothpaste (Vademecum MFP Fluor) as a negative control. 9 dental students, in a randomized sequence, applied the 4 dentifrices twice daily from Monday afternoon to Friday morning with cap splints, designed to cover the teeth and about 2 mm of gingiva. No other oral hygiene measures were allowed during the 4 test periods. On Fridays, the teeth were cleaned professionally and good oral hygiene was maintained during the week-ends. At the beginning and at the end of each test period, per student plaque thickness was recorded using the plaque index, the visible plaque index, and plaque fresh weight as parameters, and the area of plaque as related to the area of the tooth surface was recorded planimetrically and according to the PLQ index. The best plaque growth-inhibiting effect was recorded for the positive control (CHX) with the test chlorhexidine toothpaste (TX) as next best. The enzyme-containing toothpaste (TE) did not differ significantly from the negative control (C). All the significant differences in anti-plaque effect between the 4 toothpastes were obtained by recordings of plaque thickness and none on the basis of area of plaque.

  8. Eagle in flight:A study of folk custom park landscape design in Linqu%鸢飞鱼跃、百福骈臻——临朐民俗风情园景观规划设计

    Institute of Scientific and Technical Information of China (English)

    鲁敏; 王菲; 康文凤

    2011-01-01

    A folk park is a city park element which is of great significance in showing the city' s folk culture and local culture, and the exploration of folk custom park in the garden city construction has become a focus in related research fields. Iinqu folk custom park landscape is planned and designed as an important part of Weifang "Trinidad Folk Tour line". Based on the environmental situation of design,according to Linqu local folk customs,in order to show and explore the cultural and historical connotation in Linqu,it is designated as the landscape structure of "a main line,two squares,six thematic parks". The theme of hawk flying and fish leaping is highlighted by making the kite flying pieces and the fish-shaped square. The city's historical and cultural connotation,public activity needs,ecological requirements and other factors are combined together to plan and design a style garden with beautiful scenery and profound cultural connotation.%民俗公园是城市公园的构成要素,对展现城市民俗文化和地域文化具有重要的意义,在园林城市建设中对民俗风情园的探索已经成为相关领域研究的热点.临朐民俗风情园景观规划设计定位为潍坊市“千里民俗游览线”的重要组成部分,是基于对设计范围内的环境现状,以临朐当地民俗民风为依据,展示和发掘临朐民俗文化及历史内涵,将民俗风情园规划为“一条主线、二个广场、六个专题园区”的景观设计结构,通过塑造鸢飞的小品以及鱼形广场,突出鸢飞鱼跃的主题,将该城市的历史文化内涵、市民活动需求、生态要求等要素结合起来,规划设计出一个风景秀丽、文化内涵深厚的风情园.

  9. Making Product Customization Profitable

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Hvam, Lars; Haug, Anders

    2010-01-01

    The main result presented in this paper is the Framework for Product Family Master Plan. This framework supports the identification of a product architecture for companies that customize products and services. The framework has five coherent aspects, the market, product assortment, supply...

  10. 基于jQuery的自定义插件开发%Design of Custom Plug-in Based on jQuery

    Institute of Scientific and Technical Information of China (English)

    高齐琦; 张素伟

    2016-01-01

    Since the continuous development of web based technologies, jQuery script libraries and plug- in techn-ology have been widely applied. In this paper, the basic modes and specialties of custom plug-in using jQuery script library were introduced. A common object-level plug-in will be an example to introduce the process of developing and applying. In addition, the class-level plug-ins were also briefly described.%随着web技术的不断发展,jQuery脚本库和插件技术已经被广泛的使用。本文主要介绍了基于jQuery脚本库开发自定义插件的基本模式和要点。通过编写插件开发中最为常见的对象级别的插件,讲述了插件的开发过程和引用方式。也简略介绍了类级别的插件及其开发引用方式。

  11. Comparative evaluation of pressure generated on a simulated maxillary oral analog by impression materials in custom trays of different spacer designs: An in vitro study.

    Science.gov (United States)

    Chopra, Sakshi; Gupta, Narendra Kumar; Tandan, Amrit; Dwivedi, Ravi; Gupta, Swati; Agarwal, Garima

    2016-01-01

    Literature reveals that masticatory load on denture bearing tissues through complete dentures should be maximum on primary stress bearing areas and least on relief area in accordance with the histology of underlying tissues. A study to validate the existing beliefs was planned to compare the pressure on mucosa using selective pressure technique and minimal pressure technique, with the incorporation of two different impression materials utilizing the pressure sensors during secondary impression procedure. The study was performed using a maxillary analog. Three pressure sensors were imbedded in the oral analog, one in the mid palatine area and the other two in the right and left ridge crest. Custom trays of two different configurations were fabricated. The two impression materials tested were light body and zinc oxide eugenol. A total of 40 impressions were made. A constant weight of 1 kg was placed, and the pressure was recorded as initial and end pressures. A significant difference in the pressure produced using different impression materials was found (P materials. The presence of relief did affect the magnitude of pressure at various locations. All impression materials produced pressure during maxillary edentulous impression making. Tray modification is an important factor in changing the amount of pressure produced. The impression materials used also had a significant role to play on the pressures acting on the tissues during impression procedure. Light body VPS impression material may be recommended to achieve minimal pressure on the denture bearing tissues in both selective as well as minimal pressure techniques.

  12. State-of-the-art assessment of testing and testability of custom LSI/VLSI circuits. Volume 2: Hardware design verification

    Science.gov (United States)

    Carlan, A. J.; Breuer, M. A.

    1982-10-01

    The complexity of digital circuits requires that more emphasis be placed on design specifications and verification. Specification of design requirements currently advocated is done with formal hardware descriptive languages (HDLs) to describe hardware function. Industry's current use of HDLs is primarily for simulation. Verifying a design is a less mature discipline. Three approaches are considered: simulation, symbolic simulation amd formal proofs. While symbolic simulation shows promise, much research and development is required.

  13. The computer assisted design of the custom prosthesis for acetabular dysplasia%成人髋臼发育不良的个性化股骨假体设计

    Institute of Scientific and Technical Information of China (English)

    刘国强; 白波; 孙辉; 廖壮文

    2009-01-01

    目的 探讨个性化股骨假体计算机辅助设计在成人髋臼发育不良(AD)行全髋关节置换术中的应用.方法 取1例AD女性患者的髋关节和股骨全长CT扫描数据,直接以Dicom格式导入Mimics 10.01矢量化处理后建立股骨三维模型,提取股骨髓腔轮廓并重组三维模型.上述模型通过Solid Work 2005完成假体的优化处理.最后利用Mimics平台装载STL功能以及手术模拟模块完成假体虚拟植入.结果 实现了基于CT二维资料的三维重建,设计的假体与患者股骨髓腔匹配良好,通过模拟假体良好装配帮助解决假体前倾角调整,髓腔匹配等一系列问题.结论 以现代CT扫描所获得的二维影像资料在Mimics的矢量化处理后能获得精确的股骨三维模型;提取股骨髓腔并重建模型方便准确,与计算机辅助设计软件相结合可以设计出个性化股骨假体.%Objective To explore the application of The computer assisted design of the custom prosthesis in total hip replacement for Acetabular Dysplasia(AD).Methods Imported the Dicom images of volunteer's femur of AD into the Mimics 10.01 to build the 3D model. Extracted the sketch of cavity of femur and rebuild the 3D model. Exported the model into the Solid Work 2005 to design the custom prosthesis and saved it as the STL file. Loaded the STL file in Mimics 10.01 and completed the virtual implantation.Results Get the 3D model based on the CT images. The custom made prosthesis matched well with the cavity of femur. Figured out the question of femoral neck anteversion through the simulated implantation of custom prosthesis.Conclusions The 3D model was precise base on the Mimics software. The method of extracting the sketch of femur was convenient and comfortable. It was a feasible way of custom prosthesis design and providing a wide prospective.

  14. 基于客户感知的IT服务质量评价指标体系设计%Design of IT Service Quality Evaluation Index System Based on Customer Perception

    Institute of Scientific and Technical Information of China (English)

    梁奂; 陈春华; 乔宏明

    2015-01-01

    在研究SERVQUAL服务质量模型的基础上,分析了电信企业IT服务管理的现状,设计了基于客户感知的IT服务质量评估模型,并编制了相应的评估指标。评估体系共4大类23个指标,与客户感知密切相关的指标有13个。本评估指标已在某电信公司的IT服务质量评估中应用,实践证明对提升IT服务质量有较好的促进作用。%Based on SERVQUAL model, the status of IT service management of telecom enterprises was analyzed, an evaluation model of IT service quality based on customer perception was designed and corresponding evaluation indexes was drawn up in this paper. This evaluation system has twenty three indexes of four sorts in which thirteen of these indexes are relevant to customer perception. This evaluation system has been applied to the IT service quality evaluation of a certain telecom company. Practice shows that it promotes the enhancement of IT service quality well.

  15. Design and construction of custom-made neoprene thumb carpo-metacarpal orthosis with thermoplastic stabilization for first carpo-metacarpal joint osteoarthritis.

    Science.gov (United States)

    Bani, Monireh Ahmadi; Arazpour, Mokhtar; Curran, Sarah

    2013-01-01

    Individuals with first carpo-metacarpal (CMC) osteoarthritis (OA) often experience pain and difficulty with functional activities. Thus, designing orthotics to improve function and decrease pain is common practice. These therapists designed an orthosis using a combination of neoprene and thermoplastic materials to create a soft orthosis that provides support to the first CMC joint - Victoria Priganc, PhD, OTR, CHT, CLT.

  16. The effect of a chlorhexidine regimen on de novo plaque formation.

    Science.gov (United States)

    Sekino, Satoshi; Ramberg, Per; Uzel, Naciye Guzin; Socransky, Sigmund; Lindhe, Jan

    2004-08-01

    To evaluate the effect of a pretreatment regimen that combined meticulous mechanical tooth cleaning with the daily use of chlorhexidine (rinse, gargle and tongue application) on de novo plaque formation and on the recolonization of various microbiological species in plaque and saliva during a 4-day period of no oral hygiene. Ten subjects aged 24-36 years with gingivitis were recruited. The study was designed as a double blind cross-over clinical trial including two phases. Each experimental phase comprised one preparatory period of 7 days and one plaque accumulation period of 4 days. During the preparatory period, the volunteers (i) performed meticulous mechanical tooth cleaning using toothbrush and dentifrice and (ii) were, in addition, given two sessions of professional tooth cleaning (PTC) The final PTC was delivered after bacterial sampling had been made on Day 0. In the Control group, no additional plaque control measures were included. In the Test group, the participants in addition to the mechanical measures (i) rinsed twice daily, for 60 s each time with a 0.2% chlorhexidine solution, (ii) gargled twice daily for 10 s with the chlorhexidine preparation, and finally (iii) brushed the dorsum of the tongue for 60 s, twice daily, with a 1.0% chlorhexidine gel. During the 4-day plaque accumulation period, the participants abstained from all mechanical and chemical plaque control measures. On Days 0, 1, 2 and 4 the quantity and quality of plaque formed was assessed by clinical means and by DNA probe techniques. The microbiota of the saliva was studied in samples obtained on Days 0 and 4. It was demonstrated that chlorhexidine used as a mouthrinse combined with gargling and tongue application during the preparatory period significantly retarded the amount of plaque that formed on tooth surfaces during the following 4 days of no oral hygiene. Further, the number of microorganisms present in the biofilm representing Days 0, 1 and 2 of the "plaque accumulation period

  17. Empirical research on Kano's model and customer satisfaction.

    Science.gov (United States)

    Lin, Feng-Han; Tsai, Sang-Bing; Lee, Yu-Cheng; Hsiao, Cheng-Fu; Zhou, Jie; Wang, Jiangtao; Shang, Zhiwen

    2017-01-01

    Products are now developed based on what customers desire, and thus attractive quality creation has become crucial. In studies on customer satisfaction, methods for analyzing quality attributes and enhancing customer satisfaction have been proposed to facilitate product development. Although substantial studies have performed to assess the impact of the attributes on customer satisfaction, little research has been conducted that quantitatively calculate the odds of customer satisfaction for the Kano classification, fitting a nonlinear relationship between attribute-level performance and customer satisfaction. In the present study, the odds of customer satisfaction were determined to identify the classification of quality attributes, and took customer psychology into account to suggest how decision-makers should prioritize the allocation of resources. A novel method for quantitatively assessing quality attributes was proposed to determine classification criteria and fit the nonlinear relationship between quality attributes and customer satisfaction. Subsequently, a case study was conducted on bicycle user satisfaction to verify the novel method. The concept of customer satisfaction odds was integrated with the value function from prospect theory to understand quality attributes. The results of this study can serve as a reference for product designers to create attractive quality attributes in their products and thus enhance customer satisfaction.

  18. Customized products and cloud service information system development research

    Directory of Open Access Journals (Sweden)

    Hung Chien-Wen

    2017-01-01

    Full Text Available This study presents a cloud service customized product information system to enable businesses to provide customized product marketing on the Internet to meet consumer demand for customized products. The cloud service of the information system development strategic framework proposed in this study contains three elements: (1 e-commerce services, (2 promotion type modules, and (3 cloud services customized promotional products. In this study, a mining cloud information system to detect customer behavior is proposed. The association rules from relational database design are utilized to mine consumer behavior to generate cross-selling proposals for customer products and marketing for a retailing mall in Taiwan. The study is composed of several parts, as follows. A market segment and application of association rules in data exploration techniques (Association Rule Mining and sequence-like exploration (Sequential Pattern Mining, efficient analysis of customers, consumer behavior, identification of candidates for promotional products, and using cloud service delivery and evaluation of targets to evaluate candidates for promotional products for production. However, in addition to cloud service customized promotional products, the quantity of promotional products sales varies for different customers. We strive to achieve increased customer loyalty and profits through the use of active cloud service customized promotional products.

  19. Empirical research on Kano’s model and customer satisfaction

    Science.gov (United States)

    Lin, Feng-Han; Tsai, Sang-Bing; Lee, Yu-Cheng; Hsiao, Cheng-Fu; Zhou, Jie; Wang, Jiangtao; Shang, Zhiwen

    2017-01-01

    Products are now developed based on what customers desire, and thus attractive quality creation has become crucial. In studies on customer satisfaction, methods for analyzing quality attributes and enhancing customer satisfaction have been proposed to facilitate product development. Although substantial studies have performed to assess the impact of the attributes on customer satisfaction, little research has been conducted that quantitatively calculate the odds of customer satisfaction for the Kano classification, fitting a nonlinear relationship between attribute-level performance and customer satisfaction. In the present study, the odds of customer satisfaction were determined to identify the classification of quality attributes, and took customer psychology into account to suggest how decision-makers should prioritize the allocation of resources. A novel method for quantitatively assessing quality attributes was proposed to determine classification criteria and fit the nonlinear relationship between quality attributes and customer satisfaction. Subsequently, a case study was conducted on bicycle user satisfaction to verify the novel method. The concept of customer satisfaction odds was integrated with the value function from prospect theory to understand quality attributes. The results of this study can serve as a reference for product designers to create attractive quality attributes in their products and thus enhance customer satisfaction. PMID:28873418

  20. Transportation Planning and Design for Urban Port Customs:A Case Study of Liantang Port Customs in Shenzhen%城市通关口岸交通规划设计方法与实践--以深圳市莲塘口岸为例

    Institute of Scientific and Technical Information of China (English)

    刘光辉; 白莲森; 夏国栋; 张仲瑾

    2013-01-01

    Being a special transportation terminal, ur-ban port demands for efficient customs clearance ser-vices and high-quality transportation system to meet its ever increasing expansion needs. For that, it is nec-essary to develop better transportation forecasting and planning methods. Dealing with the complex demands, a host of inspection agencies, and intensive passenger/freight demand, this paper presents the overall concept and principles for port transportation planning and de-sign. Taking Liantang Port Customs in Shenzhen as an example, the paper discusses the port transportation functionalities, effective land use development, and us-er-oriented service in several aspects:transportation de-mand forecasting, functionality zoning, general layout, distribution of infrastructure, and traffic management.%通关口岸是一种特殊的交通枢纽,为保证其提供舒适、快捷的通关服务,满足日益增长的通关需求,有必要对其进行科学的交通预测和规划设计。针对通关口岸交通需求复杂、内部查验部门多、客货需求集中的特点,提出口岸交通规划设计思路和原则。以深圳市莲塘口岸为例,从交通需求预测、功能区规模测算、口岸总体布局、建筑布置、交通组织几个方面详细阐述交通规划设计方案,探讨其如何实现口岸交通功能和高效利用城市土地资源,落实以人为本的交通理念。

  1. Alzheimer's Protein Plaques May Also Harm the Heart

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_162241.html Alzheimer's Protein Plaques May Also Harm the Heart Deposits ... fragments that form plaques in the brains of Alzheimer's patients might also stiffen their heart muscle and ...

  2. Plaque retention on elastomeric ligatures. An in vivo study

    OpenAIRE

    CONDÒ, R.; CASAGLIA, A.; CONDÒ, S.G.; Cerroni, L

    2013-01-01

    Fixed orthodontic appliances make it difficult to maintain the oral hygiene, resulting in plaque accumulation. Retention of bacterial plaque, represents a risk for white spot lesions and development of periodontal disease.

  3. Innovations in Mechatronic Products and Mass Customization

    DEFF Research Database (Denmark)

    Habib, Tufail; Jørgensen, Kaj Asbjørn; Nielsen, Kjeld

    2011-01-01

    Mass Customization (MC) has been recognized as a successful strategy in the design and development of products tailored to customer needs. Global competition demands new products with added functionalities, as in the case of mechatronic products. These products are becoming more and more important...... as a product type and new inventions have resulted in drastic changes in design and development of mechatronic products. Conventional mechanical systems are enhanced by mechatronic systems. In this paper, the particular structure and properties of mechatronic products compared to conventional mechanical...... systems is presented. The successful strategy of mass customization has contributed to innovations in the development of mechatronic products and the paper presents an overview of typical changes regarding functionalities from mechanical products towards mechatronic products....

  4. [Progress in research and application of the edentulous custom trays].

    Science.gov (United States)

    Sun, Y C; Jin, E L; Zhao, T; Wang, Y; Ye, H Q; Zhou, Y S

    2016-11-09

    Well designed and fabricated custom tray is the precondition to acquire qualified edentulous impression and key to successful complete denture. It has shown that primary impression without custom trays is hard to meet clinical requirements for successful restoration of complete denture. According to the fabrication techniques, edentulous custom tray can be classified into several types such as: compound trimming technique, handcrafted technique with polymerizing acrylic resin based on the study cast, and computer aided design and three dimensional printing(CAD & 3DP) technique based on the primary impression or study cast, etc. With regard to some special edentulous jaws, the custom tray and impression techniques such as open-window, frame cut, closed-mouth custom trays, and so on can be applied to acquire accurate impressions. All above technologies have their own characteristics and emphases. In clinic, appropriate custom trays should be selected according to residual ridge condition, oral status, and other clinical requirements of each edentulous patient.

  5. Infliximab for the treatment of plaque psoriasis

    Directory of Open Access Journals (Sweden)

    Jennifer S Gall

    2008-03-01

    Full Text Available Jennifer S Gall, Robert E KalbState University of New York at Buffalo, School of Medicine and Biomedical Sciences, Department of Dermatology, NY, USAAbstract: Infliximab is a monoclonal antibody that targets tumor necrosis factor-α (TNFα. It is used in the treatment of a number of inflammatory disorders including severe plaque psoriasis. TNFα is thought to have a major role in psoriasis by promoting an inflammatory infiltrate into the skin and inducing keratinocyte proliferation and preventing keratinocyte apoptosis, which directly contributes to the characteristic plaque skin lesions. Based on four randomized, placebo-controlled, double-blind clinical trials and nine open-label uncontrolled trials of the use of infliximab in plaque psoriasis, it was found that infliximab is a highly efficacious, rapid, sustainable, and relatively safe therapy. Yet as with any biologic, caution is recommended in its use as infusion reactions, lupus-like syndromes, infections, malignancies including lymphomas, as well as other rare events have been reported.Keywords: infliximab, psoriasis, plaque

  6. Large plaque parapsoriasis in a child

    Directory of Open Access Journals (Sweden)

    Das Jayanta

    2005-01-01

    Full Text Available A case of large plaque parapsoriasis with extensive skin lesions is presented for its unusual clinical features. The controversial issue of its nosological position is discussed as it has a considerable impact on the management of such cases.

  7. Intracoronary Thermography: a vulnerable Plaque Detection Technique?

    NARCIS (Netherlands)

    A.G. ten Have (Anna)

    2006-01-01

    textabstractThe studies reported in this thesis were performed to answer the central question: can intracoronary thermography be used for vulnerable plaque detection? To answer this question, we have identified parameters that influence intracoronary thermography measurements, and have studied to w

  8. Lipidome of atherosclerotic plaques from hypercholesterolemic rabbits.

    Science.gov (United States)

    Bojic, Lazar A; McLaren, David G; Shah, Vinit; Previs, Stephen F; Johns, Douglas G; Castro-Perez, Jose M

    2014-12-15

    The cellular, macromolecular and neutral lipid composition of the atherosclerotic plaque has been extensively characterized. However, a comprehensive lipidomic analysis of the major lipid classes within atherosclerotic lesions has not been reported. The objective of this study was to produce a detailed framework of the lipids that comprise the atherosclerotic lesion of a widely used pre-clinical model of plaque progression. Male New Zealand White rabbits were administered regular chow supplemented with 0.5% cholesterol (HC) for 12 weeks to induce hypercholesterolemia and atherosclerosis. Our lipidomic analyses of plaques isolated from rabbits fed the HC diet, using ultra-performance liquid chromatography (UPLC) and high-resolution mass spectrometry, detected most of the major lipid classes including: Cholesteryl esters, triacylglycerols, phosphatidylcholines, sphingomyelins, diacylglycerols, fatty acids, phosphatidylserines, lysophosphatidylcholines, ceramides, phosphatidylglycerols, phosphatidylinositols and phosphatidylethanolamines. Given that cholesteryl esters, triacylglycerols and phosphatidylcholines comprise greater than 75% of total plasma lipids, we directed particular attention towards the qualitative and quantitative assessment of the fatty acid composition of these lipids. We additionally found that sphingomyelins were relatively abundant lipid class within lesions, and compared the abundance of sphingomyelins to their precursor phosphatidylcholines. The studies presented here are the first approach to a comprehensive characterization of the atherosclerotic plaque lipidome.

  9. Lipidome of Atherosclerotic Plaques from Hypercholesterolemic Rabbits

    Directory of Open Access Journals (Sweden)

    Lazar A. Bojic

    2014-12-01

    Full Text Available The cellular, macromolecular and neutral lipid composition of the atherosclerotic plaque has been extensively characterized. However, a comprehensive lipidomic analysis of the major lipid classes within atherosclerotic lesions has not been reported. The objective of this study was to produce a detailed framework of the lipids that comprise the atherosclerotic lesion of a widely used pre-clinical model of plaque progression. Male New Zealand White rabbits were administered regular chow supplemented with 0.5% cholesterol (HC for 12 weeks to induce hypercholesterolemia and atherosclerosis. Our lipidomic analyses of plaques isolated from rabbits fed the HC diet, using ultra-performance liquid chromatography (UPLC and high-resolution mass spectrometry, detected most of the major lipid classes including: Cholesteryl esters, triacylglycerols, phosphatidylcholines, sphingomyelins, diacylglycerols, fatty acids, phosphatidylserines, lysophosphatidylcholines, ceramides, phosphatidylglycerols, phosphatidylinositols and phosphatidylethanolamines. Given that cholesteryl esters, triacylglycerols and phosphatidylcholines comprise greater than 75% of total plasma lipids, we directed particular attention towards the qualitative and quantitative assessment of the fatty acid composition of these lipids. We additionally found that sphingomyelins were relatively abundant lipid class within lesions, and compared the abundance of sphingomyelins to their precursor phosphatidylcholines. The studies presented here are the first approach to a comprehensive characterization of the atherosclerotic plaque lipidome.

  10. Vaporization of atherosclerotic plaques by spark erosion

    NARCIS (Netherlands)

    C.J. Slager (Cornelis); C.E. Essed; J.C.H. Schuurbiers (Johan); N. Bom (Klaas); P.W.J.C. Serruys (Patrick); G.T. Meester (Geert)

    1985-01-01

    textabstractAn alternative to the laser irradiation of atherosclerotic lesions has been developed. A pulsed electrocardiogram R wave-triggered electrical spark erosion technique is described. Controlled vaporization of fibrous and lipid plaques with minimal thermal side effects was achieved and docu

  11. Mathematical models for atherosclerotic plaque evolution

    NARCIS (Netherlands)

    Bulelzai, M.A.K.

    2013-01-01

    Atherosclerosis is a disease in which low density lipoproteins (LDL) accumulate in the arterial wall due to an inflammatory response, which is triggered by the oxidation of LDL molecules that are already present in the arterial wall. Progression of atherosclerotic plaques involves many components wh

  12. Digitate dermatosis (small-plaque parapsoriasis).

    Science.gov (United States)

    Lewin, Jesse; Latkowski, Jo-Ann

    2012-12-15

    We report a 79-year-old man with a 15-year history of elongated, finger-like, erythematous patches that are symmetrically distributed on his flanks and of small, parapsoriasis, which is a benign entity that has been the center of controversy over the years, owing to its similarities to large-plaque parapsoriasis, which is on a spectrum with mycosis fungoides.

  13. Retroperitoneal liposarcoma associated with small plaque parapsoriasis

    OpenAIRE

    Polichetti Paolo; Sgueglia Monica; Blasi Sara; Tartaglia Francesco; Tromba Luciana; Berni Alberto

    2007-01-01

    Abstract Background Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. Production of Granulocyte-Colony Stimulating Factor, alpha-fetoprotein, paraneoplastic pemphigus and leucocytosis, Acrokeratosis paraneoplastica (Bazex's syndrome) are reported. The present report describes a case of retroperitoneal liposarcoma associated with small plaque parapsoriasis. Our search in the English literature of such a ki...

  14. Comparative evaluation of pressure generated on a simulated maxillary oral analog by impression materials in custom trays of different spacer designs: An in vitro study

    Directory of Open Access Journals (Sweden)

    Sakshi Chopra

    2016-01-01

    Full Text Available Introduction: Literature reveals that masticatory load on denture bearing tissues through complete dentures should be maximum on primary stress bearing areas and least on relief area in accordance with the histology of underlying tissues. A study to validate the existing beliefs was planned to compare the pressure on mucosa using selective pressure technique and minimal pressure technique, with the incorporation of two different impression materials utilizing the pressure sensors during secondary impression procedure. Materials and Methods: The study was performed using a maxillary analog. Three pressure sensors were imbedded in the oral analog, one in the mid palatine area and the other two in the right and left ridge crest. Custom trays of two different configurations were fabricated. The two impression materials tested were light body and zinc oxide eugenol. A total of 40 impressions were made. A constant weight of 1 kg was placed, and the pressure was recorded as initial and end pressures. Results: A significant difference in the pressure produced using different impression materials was found (P < 0.001. Light body vinyl polysiloxane produced significantly lesser pressure than zinc oxide eugenol impression materials. The presence of relief did affect the magnitude of pressure at various locations. Conclusion: All impression materials produced pressure during maxillary edentulous impression making. Tray modification is an important factor in changing the amount of pressure produced. The impression materials used also had a significant role to play on the pressures acting on the tissues during impression procedure. Clinical Implication: Light body VPS impression material may be recommended to achieve minimal pressure on the denture bearing tissues in both selective as well as minimal pressure techniques.

  15. Randomized digital plaque imaging trial evaluating plaque inhibition efficacy of a novel stabilized stannous fluoride dentifrice compared with an amine fluoride/stannous fluoride dentifrice.

    Science.gov (United States)

    Bellamy, P G; Boulding, A; Farmer, S; Day, T N; Mussett, A J; Barker, M L

    2012-01-01

    To assess the plaque inhibition efficacy ofa novel 0.454% stabilized stannous fluoride test dentifrice (SnF2) to an amine fluoride/stannous fluoride marketed control dentifrice (AmF/SnF2) using digital plaque imaging analysis (DPIA). The 10-week study was a randomized, two-treatment, three-period, double-blind crossover design. Subjects brushed twice daily with their assigned dentifrice (SnF2 or AmF/SnF2) using a standard manual toothbrush during three treatment periods each lasting 17 days, separated by four-day washout periods. DPIA was used to analyze plaque coverage on facial surfaces of the 12 anterior teeth (canine to canine) by three assessments on Days 15, 16, and 17 at the end of each treatment period. Assessments were conducted the morning following no overnight brushing of facial surfaces (A.M. pre-brush), after 40 seconds of full mouth brushing with the assigned dentifrice (A.M. post-brush), and during the afternoon (P.M.). Twenty-seven subjects were randomized and completed the study. At each assessment time point, plaque levels for the SnF2 dentifrice were statistically significantly lower compared to those for the AmF/SnF2 dentifrice (21.4%, 22.6%, 24.3%, respectively; p dentifrice than with the AmF/SnF2 dentifrice. The plaque control benefits of the SnF2 dentifrice seen at the morning and afternoon time points indicated significantly better inhibition of plaque re-growth.

  16. How to strengthen customer loyalty, using customer segmentation?

    Directory of Open Access Journals (Sweden)

    MELNIC Elena Lidia

    2017-01-01

    Full Text Available Do you provide exceptional customer service?”, “Is the customer service in your company extraordinary?” “How to convert satis fied customers into loyal customers?” - are the most frequent questions of today’s managers and have driven the research on this article to getting the answer to a highly important marketing topic “How to strengthen customer loyalty using customer segmentation?”. Anyone who has bought a product or a service has probably suffered at least once from a company’s apparent indifference to what should be its first concern: the customer experiences. If this is the case, the company is in a wrong direction, since loyalty is the most powerful tool in today competitive market. To strengthen the bonds with these high-profit customers, innovative companies are deploying enterprise-wide strategies built on consumer segmentation.

  17. Oxidized LDL in carotid plaques and plasma associates with plaque instability

    National Research Council Canada - National Science Library

    Nishi, Kyoko; Itabe, Hiroyuki; Uno, Masaaki; Kitazato, Keiko T; Horiguchi, Hidehisa; Shinno, Kiyohito; Nagahiro, Shinji

    2002-01-01

    Oxidation of LDL plays a significant pathogenic role in atherosclerosis. In this study, we attempted to clarify the correlation between the morphology of human atherosclerotic plaques and the oxidized LDL (OxLDL...

  18. Inflamed psoriatic plaques: Drug toxicity or disease exacerbation?

    Directory of Open Access Journals (Sweden)

    Nidhi Jindal

    2013-01-01

    Full Text Available We are presenting a case of Methotrexate treated stable plaque psoriasis, in whom inflamed psoriatic plaques of drug toxicity were misdiagnosed as disease exacerbation. Erosive psoriatic plaques were present in the absence of biochemical or hematological derangements. Ulceration of psoriatic plaques in the presence of disturbed hematological profile is well described as a harbinger of methotrexate toxicity, but this kind of erosions in the absence of any systemic involvement is the first report of its kind.

  19. ANTESEN CUSTOMER LOYALTY PADA BUDGET HOTEL

    Directory of Open Access Journals (Sweden)

    Latifa Rahma

    2016-08-01

    Full Text Available This research discusses the effects of Service Quality on Customer Satisfaction, Customer Loyalty, and Brand Image Budget hotel (Five Budget Hotel Managed by local chain hotel. The purpose of this study were 1 to analyze the effects of Service Quality on Customer Satisfaction, 2 to analyze the effects of Service Quality on Customer Loyalty, 3 to analyze the effect of Customer Satisfaction to Customer Loyalty, 4 to analyze the effects of Service Quality on the Brand Image, 5  to analyze the influence of the Customer Satisfaction Brand Image, 6 to analyze the effect of Customer Loyalty to Brand Image. The design of this research using primary data obtained by distributing questionnaires to 250 respondents eligible stayed at the Budget Hotel at least 1 time in last 12 months. Respondents were selected using purposive sampling method and the data were analyzed using AMOS version 22.0 and SPSS version 22.0. The proposed model was tested using Structural Equation Modeling (SEM and analyzed using AMOS. This study shows that 1 Service Quality found to have an influence on Customer Satisfaction, 2 Service Quality found to have an influence on Customer Loyalty, 3 Customer Satisfaction is found to have an influence on Customer Loyalty, 4 Service Quality found to have an influence on brand image, 5 Customer Satisfaction is found to have an influence on Brand Image, 6 Customer Loyalty found to have an influence on the Brand Image. The results of this study concluded that there is a positive influence of the Service Quality on Brand Image through the Customer Satisfaction and Customer Loyalty. Future researches are recommended to increase the factor of First Impression, Favorable Location, Hotel Core

  20. Outsourcing customer support : The role of provider customer focus

    NARCIS (Netherlands)

    Wuyts, S.H.K.; Rindfleisch, A.; Citrin, A.

    2015-01-01

    An increasing number of firms are outsourcing customer support to external service providers. This creates a triadic setting in which an outsourcing provider serves end customers on behalf of its clients. While outsourcing presents an opportunity to serve customers, service providers differ in their

  1. Outsourcing customer support : The role of provider customer focus

    NARCIS (Netherlands)

    Wuyts, S.H.K.; Rindfleisch, A.; Citrin, A.

    An increasing number of firms are outsourcing customer support to external service providers. This creates a triadic setting in which an outsourcing provider serves end customers on behalf of its clients. While outsourcing presents an opportunity to serve customers, service providers differ in their

  2. Outsourcing customer support : The role of provider customer focus

    NARCIS (Netherlands)

    Wuyts, S.H.K.; Rindfleisch, A.; Citrin, A.

    2015-01-01

    An increasing number of firms are outsourcing customer support to external service providers. This creates a triadic setting in which an outsourcing provider serves end customers on behalf of its clients. While outsourcing presents an opportunity to serve customers, service providers differ in their

  3. Customer Engagement as a New Perspective in Customer Management

    NARCIS (Netherlands)

    Verhoef, Peter C.; Reinartz, Werner J.; Krafft, Manfred

    Since 2000, customer management (CM) research has evolved and has had a significant impact on the marketing discipline. In an increasingly networked society where customers can interact easily with other customers and firms through social networks and other new media, the authors propose that

  4. Managing Customer Participation and Customer Interactions in Service Delivery: the Case of Museums and Educational Services

    National Research Council Canada - National Science Library

    Marlene Amorim; Maria João Rosa; Sandra Santos

    2014-01-01

      Background and Purpose - In this study we investigate determinants of customers' quality perceptions in service processes which involve customer participation and customer to customer interaction (CCI...

  5. Carotid Magnetic Resonance Imaging A Window to Study Atherosclerosis and Identify High-Risk Plaques

    National Research Council Canada - National Science Library

    Oikawa, Minako; Ota, Hideki; Takaya, Norihide; Miller, Zach; Hatsukami, Thomas S; Yuan, Chun

    2009-01-01

    ...: the so-called "vulnerable plaque". A reliable, in vivo, imaging method capable of identifying plaque characteristics associated with high-risk plaque will be immensely useful for evaluating plaque status and predicting future events...

  6. Tensile and compressive properties of fresh human carotid atherosclerotic plaques.

    LENUS (Irish Health Repository)

    Maher, Eoghan

    2009-12-11

    Accurate characterisation of the mechanical properties of human atherosclerotic plaque is important for our understanding of the role of vascular mechanics in the development and treatment of atherosclerosis. The majority of previous studies investigating the mechanical properties of human plaque are based on tests of plaque tissue removed following autopsy. This study aims to characterise the mechanical behaviour of fresh human carotid plaques removed during endarterectomy and tested within 2h. A total of 50 radial compressive and 17 circumferential tensile uniaxial tests were performed on samples taken from 14 carotid plaques. The clinical classification of each plaque, as determined by duplex ultrasound is also reported. Plaques were classified as calcified, mixed or echolucent. Experimental data indicated that plaques were highly inhomogeneous; with variations seen in the mechanical properties of plaque obtained from individual donors and between donors. The mean behaviour of samples for each classification indicated that calcified plaques had the stiffest response, while echolucent plaques were the least stiff. Results also indicated that there may be a difference in behaviour of samples taken from different anatomical locations (common, internal and external carotid), however the large variability indicates that more testing is needed to reach significant conclusions. This work represents a step towards a better understanding of the in vivo mechanical behaviour of human atherosclerotic plaque.

  7. Three-dimensional carotid ultrasound plaque texture predicts vascular events

    DEFF Research Database (Denmark)

    van Engelen, Arna; Wannarong, Thapat; Parraga, Grace;

    2014-01-01

    carotid plaque volume and 376 measures of plaque texture. Patients were followed up to 5 years (median [range], 3.12 [0.77-4.66]) for myocardial infarction, transient ischemic attack, and stroke. Sparse Cox regression was used to select the most predictive plaque texture measurements in independent...

  8. En plaque meningioma in thoracic spine: case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyeon Seon; Kang, Ho Yeong; Yoon, Deug Hee; Jo, Byung June; Lee, Sang Ho; Choi, Young Geun [Wooridul Spine Hospital, Seoul (Korea, Republic of); Lee, Sang Yeun [Puchon Daesung Hospital, Puchon (Korea, Republic of)

    2005-07-15

    Spinal en plaque meningioma is rarely found in the spinal canal, although lateral sphenoid wing meningioma displays a propensity for growth en plaque. We encountered a case of completely circumferential spinal en plaque meningioma, which is an even rarer condition. Herein, we report the CT MRI findings along with a review of the related literature.

  9. Role of social media in retail network operations and marketing to enhance customer satisfaction

    OpenAIRE

    Ramanathan, U; Subramanian, N.; Parrott, G

    2016-01-01

    Purpose: The technology evolution compels retail networks to introduce unique business models to retain customers and to gain a competitive advantage. Customer reviews available through social media need to be taken into account by retail networks to design a model with unique service operations and marketing approaches that will improve loyalty by adding value to customers. Furthermore, the relationship between customer satisfaction and customer spending behaviour is very weak and needs furt...

  10. EOSDIS Customer Support Challenges

    Science.gov (United States)

    Moses, J. F.; Boquist, C. L.

    2006-05-01

    The Earth Observation System Data and Information System (EOSDIS) is a large, complex data system currently supporting over 18 operational NASA satellite missions including the flagship EOS missions: Terra, Aqua, and Aura. The observations collected by these missions are kept at geographically distributed data centers. EOSDIS manages over four petabytes of data accessed by over 200,000 distinct users last year. The data centers distributed more than 37 million Earth science data products during 2005 to a diverse customer community. An important goal for these data centers is to provide an adequate service at a uniform level for the user community to ensure we get the most benefit from our investment in space resources. This paper discusses the challenges, the ways the data centers coordinate among themselves to provide service, and recent results of measuring customer satisfaction with this service.

  11. Profiling the Mobile Customer

    DEFF Research Database (Denmark)

    Jessen, Pernille Wegener; King, Nancy J.

    2010-01-01

    Mobile customers are increasingly being tracked and profiled by behavioural advertisers to enhance delivery of personalized advertising. This type of profiling relies on automated processes that mine databases containing personally-identifying or anonymous consumer data, and it raises a host...... of significant concerns about privacy and data protection. This second article in a two part series on "Profiling the Mobile Customer" explores how to best protect consumers' privacy and personal data through available mechanisms that include industry self-regulation, privacy-enhancing technologies...... and legislative reform. 1 It discusses how well privacy and personal data concerns related to consumer profiling are addressed by two leading industry self-regulatory codes from the UK and the U.S. that aim to establish fair information practices for behavioural advertising by their member companies. It also...

  12. Profiling the Mobile Customer

    DEFF Research Database (Denmark)

    Jessen, Pernille Wegener; King, Nancy J.

    2010-01-01

    of significant concerns about privacy and data protection. This second article in a two part series on "Profiling the Mobile Customer" explores how to best protect consumers' privacy and personal data through available mechanisms that include industry self-regulation, privacy-enhancing technologies......Mobile customers are increasingly being tracked and profiled by behavioural advertisers to enhance delivery of personalized advertising. This type of profiling relies on automated processes that mine databases containing personally-identifying or anonymous consumer data, and it raises a host...... discusses the current limitations of using technology to protect consumers from privacy abuses related to profiling. Concluding that industry self-regulation and available privacy-enhancing technologies will not be adequate to close important privacy gaps related to consumer profiling without legislative...

  13. Custom-Designed MLPA Using Multiple Short Synthetic Probes Application to Methylation Analysis of Five Promoter CpG Islands in Tumor and Urine Specimens from Patients with Bladder Cancer

    DEFF Research Database (Denmark)

    Serizawa, R.R.; Ralfkiaer, U.; Dahl, C.

    2010-01-01

    pairs of probes that carry tails for binding of common amplification primers. Resolution of the various targets is achieved by electrophoresis on the basis of predefined differences in amplicon length. In the conventional MLPA approach, one of the two target probes is generated by cloning in a single......-stranded bacteriophage vector to introduce a sequence of defined length between the primer binding site and the specific target sequence. Here we demonstrate that differences in amplicon length can be achieved by using multiple short synthetic probes for each target sequence. When joined by a DNA ligase, these probes...... this assay to analyze DNA from tumor tissue and corresponding urine samples from patients with bladder cancer. Our data show that the use of multiple short synthetic probes provides a simple means for custom-designed MS-MLPA analysis....

  14. Custom-Designed MLPA Using Multiple Short Synthetic Probes Application to Methylation Analysis of Five Promoter CpG Islands in Tumor and Urine Specimens from Patients with Bladder Cancer

    DEFF Research Database (Denmark)

    Serizawa, R.R.; Ralfkiaer, U.; Dahl, C.

    2010-01-01

    pairs of probes that carry tails for binding of common amplification primers. Resolution of the various targets is achieved by electrophoresis on the basis of pre-defined differences in amplicon length. In the conventional MLPA approach, one of the two target probes is generated by cloning in a single......-stranded bacteriophage vector to introduce a sequence of defined length between the primer binding site and the specific target sequence. Here we demonstrate that differences in amplicon length can be achieved by using multiple short synthetic probes for each target sequence. When joined by a DNA ligase, these probes...... this assay to analyze DNA from tumor tissue and corresponding urine samples from patients with bladder cancer. Our data show that the use of multiple short synthetic probes provides a simple means for custom-designed MS-MLPA analysis. (J Mol Diagn 2010, 12:402-408; DOI: 10.2353/jmoldx.2010.090152)...

  15. Topographic association of angioscopic yellow plaques with coronary atherosclerotic plaque: assessment with quantitative colorimetry in human coronary artery autopsy specimens.

    Science.gov (United States)

    Ishibashi, Fumiyuki; Lisauskas, Jennifer B; Kawamura, Akio; Waxman, Sergio

    2008-01-01

    Yellow plaques seen during coronary angioscopy are thought to be the surrogates for superficial intimal lipids in coronary plaque. Given diffuse and heterogeneous nature of atherosclerosis, yellow plaques in coronaries may be seen as several yellow spots on diffuse coronary plaque. We examined the topographic association of yellow plaques with coronary plaque. In 40 non-severely stenotic ex-vivo coronary segments (average length: 52.2 +/- 3.1 mm), yellow plaques were examined by angioscopy with quantitative colorimetry. The segments were cut perpendicular to the long axis of the vessel at 2 mm intervals, and 1045 slides with 5 microm thick tissue for whole segments were prepared. To construct the plaque surface, each tissue slice was considered to be representative of the adjacent 2 mm. The circumference of the lumen and the lumen border of plaque were measured in each slide, and the plaque surface region was constructed. Coronary plaque was in 37 (93%) of 40 segments, and consisted of a single mass [39.9 +/- 3.9 (0-100) mm, 311.3 +/- 47.4 (0.0-1336.2) mm2]. In 30 (75%) segments, multiple (2-9) yellow plaques were detected on a mass of coronary plaque. The number of yellow plaques correlated positively with coronary plaque surface area (r = 0.77, P colorimetry, some of them are associated with lipid cores underneath thin fibrous caps, may be used to assess the extent of coronary plaque. Further research using angioscopy could be of value to study the association of high-risk coronaries with acute coronary syndromes.

  16. Mass Customization in the Electronics Industry

    DEFF Research Database (Denmark)

    Hvam, Lars

    2006-01-01

    This article describes how Amercian Power Conversion (APC), a company in the electronics industry, has used the principles of mass customization to achieve major improvements of its efficiency and performance. APC sells, designs, produces, delivers, and installs large complex infrastructure systems...

  17. Assessment of Process Robustness for Mass Customization

    DEFF Research Database (Denmark)

    Nielsen, Kjeld; Brunø, Thomas Ditlev

    2013-01-01

    In mass customization, the capability Robust Process Design defined as the ability to reuse or recombine existing organizational and value-chain resources is essential to deliver a high variety cost effectively. We argue that there is a need for methods which can assess a company’s process...

  18. Assessment of Process Robustness for Mass Customization

    DEFF Research Database (Denmark)

    Nielsen, Kjeld; Brunø, Thomas Ditlev

    2013-01-01

    In mass customization, the capability Robust Process Design defined as the ability to reuse or recombine existing organizational and value-chain resources is essential to deliver a high variety cost effectively. We argue that there is a need for methods which can assess a company’s process...

  19. Are Students Customers? TQM and Marketing Perspectives

    Science.gov (United States)

    Eagle, Lynne; Brennan, Ross

    2007-01-01

    Purpose: This paper seeks to evaluate the arguments for and against the proposition that students in higher education are "customers" and should be treated as such. Design/methodology/approach: A critical review of the relevant literature from the domains of total quality management and marketing. Findings: The debate is polarised, with advocates…

  20. Are Students Customers? TQM and Marketing Perspectives

    Science.gov (United States)

    Eagle, Lynne; Brennan, Ross

    2007-01-01

    Purpose: This paper seeks to evaluate the arguments for and against the proposition that students in higher education are "customers" and should be treated as such. Design/methodology/approach: A critical review of the relevant literature from the domains of total quality management and marketing. Findings: The debate is polarised, with advocates…