WorldWideScience

Sample records for current trends persist

  1. Trends in Social Media : Persistence and Decay

    CERN Document Server

    Asur, Sitaram; Szabo, Gabor; Wang, Chunyan

    2011-01-01

    Social media generates a prodigious wealth of real-time content at an incessant rate. From all the content that people create and share, only a few topics manage to attract enough attention to rise to the top and become temporal trends which are displayed to users. The question of what factors cause the formation and persistence of trends is an important one that has not been answered yet. In this paper, we conduct an intensive study of trending topics on Twitter and provide a theoretical basis for the formation, persistence and decay of trends. We also demonstrate empirically how factors such as user activity and number of followers do not contribute strongly to trend creation and its propagation. In fact, we find that the resonance of the content with the users of the social network plays a major role in causing trends.

  2. Persistent currents in ferromagnetic condensates

    Science.gov (United States)

    Lamacraft, Austen

    2017-06-01

    Persistent currents in Bose condensates with a scalar order parameter are stabilized by the topology of the order parameter manifold. In condensates with multicomponent order parameters it is topologically possible for supercurrents to "unwind" without leaving the manifold. We study the energetics of this process in the case of ferromagnetic condensates using a long wavelength energy functional that includes both the superfluid and spin stiffnesses. Exploiting analogies to an elastic rod and rigid body motion, we show that the current carrying state in a 1D ring geometry transitions between a spin helix in the energy minima and a solitonlike configuration at the maxima. The relevance to recent experiments in ultracold atoms is briefly discussed.

  3. Suicide: current trends.

    Science.gov (United States)

    Bailey, Rahn K; Patel, Tejas C; Avenido, Jaymie; Patel, Milapkumar; Jaleel, Mohammad; Barker, Narviar C; Khan, Jahanzeb Ali; Ali, Shahid; Jabeen, Shagufta

    2011-07-01

    Suicide is the act of a human being intentionally causing his or her own death. More than 1 million people commit suicide every year. It is the 13th leading cause of death worldwide, with China, India, and Japan accounting for almost half of all suicides. In less than 50 years, the rate of suicide among Sri Lankans has risen from a modest level to one of the highest in the world (118 per 100,000). Suicide is a major preventable cause of premature death. It is influenced by psychosocial, cultural, and environmental risk factors. The impact of suicide can be devastating for all concerned. It is common in people who are living with chronic mental illness. Individuals with severe clinical depression and alcohol use disorders are at highest risk if untreated. On an interpersonal level, friends and families of suicide victims require social support. On a national level, governments need to recognize the causes of suicide and protect those most vulnerable. If governments commit to defining national responses to prevent suicide, significant progress can be made. On a global scale, research and health organizations can identify global trends and encourage the sharing of information in effective prevention activities. In September 2010, World Suicide Prevention Day, with a theme of "Many faces, many places: suicide prevention across the world," encouraged public awareness worldwide to unite in commitment and action to promote understanding about suicide and removal of stigmatization'. There is compelling evidence that adequate prevention and awareness can reduce suicide rates.

  4. Current trends in minilaparoscopy.

    Science.gov (United States)

    Small Layne, Alyssa; Pinkard, Lauren; Shepherd, Jessica

    2016-08-01

    The purpose of this review is to understand the current use of minilaparoscopy in the field and how minilaparoscopy compares with traditional laparoscopy in terms of operative times, complications, pain, and cosmesis. Although there are few randomized controlled trials comparing minilaparoscopy with traditional laparoscopy in gynecologic procedures, the results suggest that minilaparoscopy can be performed safely with improved cosmetic outcomes and similar complication rates and operating times. Postoperative pain may be decreased with minimizing incisions sizes. Recently, case reports and case series have been published demonstrating the use of minilaparoscopy across many subtypes of gynecologic surgery. Traditional laparoscopic surgery has become common practice in gynecology as it has been found to be a well tolerated procedure with improved outcomes and decreased morbidity when compared with laparotomy. Although minilaparoscopy has been used for over 2 decades, its role in gynecology is continuing to evolve. Minilaparoscopy is a growing surgical option in gynecology as we try to minimize the impact of surgery. Results of minilaparoscopy in gynecology mirror those found in urology and general surgery. Although research is limited, minilaparoscopy has proven to be a well tolerated alternative for gynecology.

  5. Current Trends in Sinonasal Imaging.

    Science.gov (United States)

    Huang, Benjamin Y; Senior, Brent A; Castillo, Mauricio

    2015-11-01

    As endoscopic sinus surgery (ESS) has evolved since its introduction to the United States, so has technology for imaging the sinonasal cavities. Although imaging is most frequently performed for evaluating chronic sinusitis refractory to medical therapy, its uses have expanded beyond inflammatory sinus disease. Multidetector Computed Tomography is the current workhorse for both diagnosis and preoperative planning in prospective ESS patients, while MR imaging remains a complementary tool for evaluating suspected tumors or intracranial and orbital complications of rhinosinusitis. In this article, the authors review current trends and potential future directions in the use of these modalities for sinus imaging.

  6. Global contamination trends of persistent organic chemicals

    National Research Council Canada - National Science Library

    Loganathan, Bommanna G; Lam, Paul K. S

    2012-01-01

    "Composed by a diverse group of experts, this reference covers the history, present status, and projected future trends of environmental contamination from highly toxic synthetic chemical pollutants...

  7. Persistent current in small superconducting rings.

    Science.gov (United States)

    Schwiete, Georg; Oreg, Yuval

    2009-07-17

    We study theoretically the contribution of fluctuating Cooper pairs to the persistent current in superconducting rings threaded by a magnetic flux. For sufficiently small rings, in which the coherence length xi exceeds the radius R, mean field theory predicts a full reduction of the transition temperature to zero near half-integer flux. We find that nevertheless a very large current is expected to persist in the ring as a consequence of Cooper pair fluctuations that do not condense. For larger rings with R>xi, we calculate analytically the susceptibility in the critical region of strong fluctuations and show that it reflects competition of two interacting complex order parameters.

  8. Persistent collective trend in stock markets

    Science.gov (United States)

    Balogh, Emeric; Simonsen, Ingve; Nagy, Bálint Zs.; Néda, Zoltán

    2010-12-01

    Empirical evidence is given for a significant difference in the collective trend of the share prices during the stock index rising and falling periods. Data on the Dow Jones Industrial Average and its stock components are studied between 1991 and 2008. Pearson-type correlations are computed between the stocks and averaged over stock pairs and time. The results indicate a general trend: whenever the stock index is falling the stock prices are changing in a more correlated manner than in case the stock index is ascending. A thorough statistical analysis of the data shows that the observed difference is significant, suggesting a constant fear factor among stockholders.

  9. Current trends of banking innovations

    Directory of Open Access Journals (Sweden)

    A.M. Karminskiy

    2013-06-01

    Full Text Available The current stage of the global banking system development takes place in an increasingly competitive environment and unstable financial markets. One of the key factors of bank's successful development is a policy of continuous innovative behavior. Nowadays innovation is a key factor of bankingnstability, competitiveness and sustainable growth.The aim of the article. The main goal of this article is to examine key trends of banking innovations and innovative in Russia. Experience in the development of new banking products, services and technologies in the Russian market is mainly based on international practice. Noteworthy is the fact that Russian banks take over not only the successful practice of new product lines, but also information technology as well as key methodological aspects of bank management and the technological aspects related the business processes.The results of the analysis. Innovative policy in the credit institution must not take place spontaneously. The positive effect of innovation can be achieved only if there is the possibility of managing the innovation process, which is not possible without a clearly highlighted definition and characteristics of banking innovation, which at least would allow distinguishing of innovation and modification. The paper describes the main aspects of the morphology of banking innovation with the detailed classification depended on the variety of attributes from its origin to the direction of action and highlights the major trends of current banking innovation, such as:development of information and cyber technology (and hence the possibility of the emergence of computational complexity and risk prediction models, the development of information security tools,etc.;implementation of customer-oriented model as the best practice;optimization of its own business processes.The article shows a number of real examples of each kind of banking innovation including the innovations in the non

  10. CURRENT TRENDS IN HOSPITALITY INDUSTRY

    Directory of Open Access Journals (Sweden)

    Ivica Batinić

    2013-10-01

    Full Text Available Hospitality industry is a complex product-service economic activity which besides accommodation, food and beverages offers a variety of complementary and ancillary services in order to meet modern needs, demands and desires of tourists consumers. Contemporary needs, demands and desires of tourists consumers (increased need for security and preservation of health; emphasis on ecology and healthy food; pure nature stay; growing demand for adventure activities and excitement; convention facilities and incentive offerings; visits to towns, big sports, cultural, religious, business events; new travel motivation have led to the emergence of new trends in hospitality offering design. Wellness and spa hotels, boutique hotels, all inclusive hotels, slow-food restaurants, and wine and lounge bars are just some of the main trends, and successful hoteliers and caterers will examine each of the trends and devise development politics in accordance with the new requirements and global market needs.

  11. CURRENT TRENDS IN INTERNATIONAL BUSINESS

    Directory of Open Access Journals (Sweden)

    Evgeny V. Ryabinin

    2015-01-01

    Full Text Available The methodological bases of researchof international business are stated in the article. The great attention is focused on analysis of main trends in development of international. The comparison of competitiveness to of most used forms ofinternational business, as well as identified the main problems and barriers of theinternational business structures.

  12. CURRENT TRENDS IN INTERNATIONAL BUSINESS

    OpenAIRE

    Evgeny V. Ryabinin

    2015-01-01

    The methodological bases of researchof international business are stated in the article. The great attention is focused on analysis of main trends in development of international. The comparison of competitiveness to of most used forms ofinternational business, as well as identified the main problems and barriers of theinternational business structures.

  13. Persistent currents in normal metal rings.

    Science.gov (United States)

    Bluhm, Hendrik; Koshnick, Nicholas C; Bert, Julie A; Huber, Martin E; Moler, Kathryn A

    2009-04-03

    The authors have measured the magnetic response of 33 individual cold mesoscopic gold rings, one ring at a time. The response of some sufficiently small rings has a component that is periodic in the flux through the ring and is attributed to a persistent current. Its period is close to h/e, and its sign and amplitude vary between rings. The amplitude distribution agrees well with predictions for the typical h/e current in diffusive rings. The temperature dependence of the amplitude, measured for four rings, is also consistent with theory. These results disagree with previous measurements of three individual metal rings that showed a much larger periodic response than expected. The use of a scanning SQUID microscope enabled in situ measurements of the sensor background. A paramagnetic linear susceptibility and a poorly understood anomaly around a zero field are attributed to defect spins.

  14. Persistence and Time Trends in the Temperatures in Spain

    Directory of Open Access Journals (Sweden)

    Luis A. Gil-Alana

    2009-01-01

    Full Text Available This paper deals with the analysis of the temperatures in several locations in Spain during the last 50 years. We focus on the degree of persistence of the series, measured through a fractional differencing parameter. This is crucial to properly estimate the parameters of the time trend coefficients in order to determine the degree of warming in the area. The results indicate that all series are fractionally integrated with orders of integration ranging between 0 and 0.5. Moreover, the time trend coefficients are all positive though they are statistically insignificant, which is in contrast with the results based on nonfractional integration.

  15. Current trends and future directions

    DEFF Research Database (Denmark)

    Harboe, Peter G.; Madsen, Sabine; Svejvig, Per

    2012-01-01

    This book is an attempt to gather current state-of-the-art research on project management from multiple universities and university colleges in Denmark. This chapter first discuss a literature review of Danish and Scandinavian research on project management thereby complementing the short review...

  16. Current trends and future directions

    DEFF Research Database (Denmark)

    Harboe, Peter G.; Madsen, Sabine; Svejvig, Per

    2012-01-01

    This book is an attempt to gather current state-of-the-art research on project management from multiple universities and university colleges in Denmark. This chapter first discuss a literature review of Danish and Scandinavian research on project management thereby complementing the short review...

  17. Pediatric thoracic trauma: Current trends.

    Science.gov (United States)

    Pearson, Erik G; Fitzgerald, Caitlin A; Santore, Matthew T

    2017-02-01

    Pediatric thoracic trauma is relatively uncommon but results in disproportionately high levels of morbidity and mortality when compared with other traumatic injuries. These injuries are often more devastating due to differences in children׳s anatomy and physiology relative to adult patients. A high index of suspicion is of utmost importance at the time of presentation because many significant thoracic injuries will have no external signs of injury. With proper recognition and management of these injuries, there is an associated improved long-term outcome. This article reviews the current literature and discusses the initial evaluation, current management practices, and future directions in pediatric thoracic trauma. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. [Current trends in dental practice].

    Science.gov (United States)

    Marković, Dubravka; Blazić, Larisa; Durić, Milanko; Vucinić, Predrag; Blagojević, Duska; Bajkin, Branislav

    2007-01-01

    This paper reviews recent trends in basic dental disciplines and advantages of new clinical procedures over conventional. Post and core restoration is one of the most common treatment modalities applied when the remaining coronal tooth structure is not sufficient to provide the necessary retention form for restoration. Nowadays, the restoration of endodontically treated teeth is based on the use of materials with a modulus of elasticity similar to that of dentin. Polymerization contraction stress of resin based composite during light-activation process may be reduced by various illumination schemes. Successful curing depends on the calculated energy density values (spatial irradiance x irradiation period - J/cm2) rather than on light irradiance levels (mW/cm2). It is well documented that various systemic diseases have a profound effect on periodontal tissues. Recently, it has been speculated that periodontal disease may influence systemic health and represent the risk factor for cardiovascular diseases or adverse pregnancy outcomes. Computer systems, which will automatically identify relevant skeletal and soft tissue roentgencephalometric landmarks, will represent a great improvement in the field of orthodontic diagnosis. By using the Active Appearance Model, it is possible to identify most of roentgencephalometric bony landmarks with an average error well below 2 mm. Chemomechanical caries removal was introduced as an alternative to conventional mechanical procedures. Its advantages are: selective removal of carious tissue, absence of pain, reduced need for local anesthesia and less potentially negative effects on the dental pulp. The introduction of the surgical operating microscope, microsurgical instruments, ultrasonic retrotips for root-end cavity preparation and new root-end filling materials opened a new era in periapical surgery, even on multi-rooted teeth, often called endodontic microsurgery.

  19. Digital library research : current developments and trends

    OpenAIRE

    Shiri, Ali

    2003-01-01

    This column gives an overview of current trends in digital library research under the following headings: digital library architecture, systems, tools and technologies; digital content and collections; metadata; interoperability; standards; knowledge organisation systems; users and usability; legal, organisational, economic, and social issues in digital libraries.

  20. Current Trends in Higher Education Technology: Simulation

    Science.gov (United States)

    Damewood, Andrea M.

    2016-01-01

    This paper is focused on how technology in use changes over time, and the current trend of simulation technology as a supported classroom technology. Simulation-based training as a learning tool is discussed within the context of adult learning theories, as is the technology used and how today's higher education technology administrators support…

  1. Current Trends in Leisure Sports in Canada

    Institute of Scientific and Technical Information of China (English)

    凯伦·丹尼贾克

    2017-01-01

    The purpose of this study was to explore the current trends in leisure sports in Canada. Based on physical activity and sport participation levels investigation conducted by Statistics Canada and the Ca-nadian Fitness and Lifestyle Research Institute,this paper provided an overview of the most recent findings on participation of leisure,sport,physical activity,and exercise of Canadians.

  2. First birth trends in developed countries: Persisting parenthood postponement

    Directory of Open Access Journals (Sweden)

    Jean-Paul Sardon

    2006-09-01

    Full Text Available Levels and trends of various facets concerning first births are continuously changing. The evidence confirms that the postponement of first births is an ongoing and persisting process which started in western countries among cohorts of the 1940s, but only in the 1960s cohorts in Central and Eastern Europe. The mean age of women having first births is universally rising. Fertility of older women was increasing. The decline in childbearing of young women is robust among the cohorts of the late 1960s and the 1970s; in Southern Europe as well as in central and Eastern Europe the rates of decline have accelerated. Childbearing behavior in the formerly socialist countries is in transition to a different regime.

  3. Testing reanalysis datasets in Antarctica: Trends, persistence properties and trend significance

    CERN Document Server

    Wang, Yang; Havlin, Shlomo

    2015-01-01

    The reanalysis datasets provide very important sources for investigating the climate dynamics and climate changes in Antarctica. In this paper, three major reanalysis data are compared with Antarctic station data over the last 35 years: the National Centers for Environmental Prediction and the National Center for Atmospheric Research reanalysis (NCEP1), NCEP-DOE Reanalysis 2 (NCEP2), and the European Centre for Medium-Range Weather Forecasts Interim Re-Analysis (ERA-Interim). In our assessment, we compare the linear trends, the fluctuations around the trends, the persistence properties and the significance level of warming trends in the reanalysis data with the observational ones. We find that NCEP1 and NCEP2 show spurious warming trends in all parts of Antarctica except the Peninsula, while ERA-Interim is quite reliable except at Amundsen-Scott. To investigate the persistence of the data sets, we consider the lag-1 autocorrelation $C(1)$ and the Hurst exponent. While $C(1)$ varies quite erratically in differ...

  4. Brucellosis in Mexico: current status and trends.

    Science.gov (United States)

    Luna-Martínez, J Eduardo; Mejía-Terán, Claudia

    2002-12-20

    Traditionally, Mexico has been recognized as endemic with brucellosis. The improvements in diagnostics techniques and vaccination strategies and the enforcement of a national eradication policy have contributed significantly to making progress in the control of brucellosis. The current status of brucellosis and its risk factors, in the different production species as well as in human population is reviewed. Also the trends in control and eventual eradication strategies and perspectives for the near future of Mexico are presented.

  5. Current trends in Bayesian methodology with applications

    CERN Document Server

    Upadhyay, Satyanshu K; Dey, Dipak K; Loganathan, Appaia

    2015-01-01

    Collecting Bayesian material scattered throughout the literature, Current Trends in Bayesian Methodology with Applications examines the latest methodological and applied aspects of Bayesian statistics. The book covers biostatistics, econometrics, reliability and risk analysis, spatial statistics, image analysis, shape analysis, Bayesian computation, clustering, uncertainty assessment, high-energy astrophysics, neural networking, fuzzy information, objective Bayesian methodologies, empirical Bayes methods, small area estimation, and many more topics.Each chapter is self-contained and focuses on

  6. CURRENT TRENDS OF MICRO- AND NANOMECHANICS

    Institute of Scientific and Technical Information of China (English)

    Wanlin Guo; Huiming Xie; Quanshui Zheng

    2009-01-01

    @@ Introduction Scaling down to the micro- and nanoscale is a strong current trend in the development of science and technology. 'Small is energy efficient and cost effective' has long been for the motto of the semiconductor industry, including micro- and nanoelectronics, micro-electro-mechanical systems (MEMS) and nano- electro-mechanical systems (NEMS). But shrinking to small scales brings big challenges to traditional disciplines, including mechanics.

  7. [Current forms of persistent chronic hallucinatory psychosis].

    Science.gov (United States)

    Le Roux, A

    1980-12-01

    The persistency of the "Psychose Hallucinatoire Chronique" (P.H.C.) in the french psychiatric nosology can be understood through a study of the history of ideas, since the beginning of the century, about chronic delusions. Ancient authors' descriptions (Ballet, Clérambault) agree with a semiological reality often observed now. The present clinical-looking of the "P.H.C." allows to establish that: the mechanisms used by the delusion have been little altered through time, the themes taken are impregnated by late scientific discoveries and with present socio-political context, the frequency of evolution to encysted forms have increased with modern chemical therapeutics. The function of hallucinatory delusion often appears to make up for successive frustrations, sexual and affective insufficiency or sensorial isolations, and then avoids too painful suffering to the patient. To day, the attitude of psychiatrist towards hallucinated delirious patients is centred on the discovery of the personality and the biography of the patient rather than on the complete analysis of the semiology obtained in spite of reticence.

  8. Can trade opportunities and returns be generated in a trend persistent series? Evidence from global indices

    Science.gov (United States)

    Mitra, S. K.; Bawa, Jaslene

    2017-03-01

    In this study, we explore the possibility of generating trade opportunities and returns when a financial stock index series is trend persistent. Through application of Hurst coefficient based on the modified range to standard deviation analysis (Weron, 2002) in a sample of 31 leading global indices during the period December 2000 to November 2015, we found periods of trend persistence. We developed and tested a set of trading strategies on these periods of trend persistent in the financial series and found that significant positive returns can be generated when a series displayed upward trend persistence.

  9. Ethernet Networks: Current Trends and Tools

    CERN Document Server

    El-Sayed, Abdulqader M

    2009-01-01

    Ethernet topology discovery has gained increasing interest in the recent years. This trend is motivated mostly by increasing number of carrier Ethernet networks as well as the size of these networks, and consequently the increasing sales of these networks. To manage these networks efficiently, detailed and accurate knowledge of their topology is needed. Knowledge of a network's entities and the physical connections between them can be useful in various prospective. Administrators can use topology information for network planning and fault detecting. Topology information can also be used during protocol and routing algorithm development, for performance prediction and as a basis for accurate network simulations. From a network security perspective, threat detection, network monitoring, network access control and forensic investigations can benefit from accurate network topology information. In this paper, we analyze market trends and investigate current tools available for both research and commercial purposes...

  10. Experimental Setup for the Investigation of Superconducting Persistent Current

    Science.gov (United States)

    2015-09-01

    NOTES 14. ABSTRACT We report on a recent experimental setup for the investigation of the relaxation rate of the persistent current in an assembly of...at cryo-temperatures in magnetic field at time scale of seconds to hours. 15. SUBJECT TERMS persistent current, 2G HTS, coated conductor, relaxation ... activation . One unknown aspect is the variation of the coils’ position with temperature from room to cryogenic. A better design of the coils assembly

  11. Persistent spin current in nano-devices and definition of the spin current

    OpenAIRE

    Sun, Qing-feng; Xie, X. C.; WANG Jian

    2008-01-01

    We investigate two closely related subjects: (i) existence of a pure persistent spin current in semiconducting mesoscopic device with a spin-orbit interaction's (SOI), and (ii) the definition of the spin current in the presence of SOI. Through physical argument from four physical pictures in different aspects, we provide strong evidences that the persistent spin current does exist in a device with SOI in the absence of any magnetic materials. This persistent spin current is an analog of the p...

  12. Development of BSCCO persistent current system

    Energy Technology Data Exchange (ETDEWEB)

    Joo, Jin Ho; Nah, Wan Soo; Kang, Hyung Koo; Yoo, Jung Hoon [Sungkyunkwan University, Seoul (Korea)

    1998-05-01

    We have developed temperature-variable critical current measurement device for high Tc superconducting wires. For this end, vacuum shroud was designed and fabricated, and that both signal lines and power lines into the vacuum shroud were installed on it. Secondly, the design procedures for the PCS were established for the high Tc superconducting wires based on the electrical circuit analyses during energizations. We have also evaluated mechanical properties such as hardness, strength and elongation of sheath alloys made by addition of Cu, Mg, Ti, Zr and Ni to Ag matrix using induction melting furnace. It was observed that hardness and strength were improved by increasing additive contents from 0.05 to 0.2 at.%. Specifically, the increment of strength was relatively higher for alloys made by addition of Mg, Cu and Zr elements than that made by Ni and Ti addition. On the other hand, elongation was measured to be significantly reduced for former sheath alloy materials. (author). 12 refs., 13 figs., 4 tabs.

  13. Current Trends in Tactical Missile Guidance

    Directory of Open Access Journals (Sweden)

    S. Vathsal

    2005-07-01

    Full Text Available The problem of tactical missile guidance is very challenging and has been treated using several basic metlfodologies in the past four decades. Major techniques can be grouped underclassical guidance laws, modern guidance laws, l'aws for manoeuvring targets, predictive guidance for endgame scenario, and guidance laws based on intelligent control methods. Each technique has some advantages and disadvantages while implementing in a practical system. Guidance law selection is dictated by nature of flight profile like boost, midcourse, terminal homing, etc, and also miss-distance and a single-shot kill probability. This paper presents a brief survey of the existing techniques and current trends in tactical missile guidance.

  14. Current trends in context-aware applications

    Directory of Open Access Journals (Sweden)

    Andrea Loayza

    2013-12-01

    Full Text Available (Received: 2013/10/07 - Accepted: 2013/12/10Context-aware applications adapt their behavior and settings according to the environment conditions and to the user preferences. This state-of-the-art survey identifies the current trends related to the technics and tools for the development of this kind of software, as well as the areas of interest of the scientific community on the subject. It stands out the research on multimodal interfaces, localization, activity detection, interruptions control, predictive and wellbeing applications.

  15. Filtering Spam: Current Trends and Techniques

    Directory of Open Access Journals (Sweden)

    Geerthik S.

    2013-07-01

    Full Text Available This article gives an overview about latest trend and techniques in spam filtering. We analyzed the problems which is introduced by spam ,what spam actually do and how to measure the spam .This article mainly focuses on automated, non-interactive filters, with a broad review ranging from commercial implementations to ideas confined to current research papers. The solutions using both machine and non –machine learning approaches are reviewed and taxonomy of different approaches is presented. While a range of different techniques have and continue to be evaluated in academic research, heuristic and Bayesian filtering, along with its variants provide the greatest potential for future spam prevention.

  16. Persistent currents in three-dimensional shell-doped nanorings

    Institute of Scientific and Technical Information of China (English)

    Xu Ning; Ding Jian-Wen; Chen Hong-Bo; Ma Ming-Ming

    2009-01-01

    The persistent current in three-dimensional (P×N2) nanorings as a function of the unit cell number (P), the channel number (M = N2), surface disorder (ξ), and temperature (T) is theoretically investigated in terms of rotational symmetry. On the whole, the typical current increases linearly with (<3) but decreases exponentially with P, while wide fluctuations exist therein. In the presence of surface disorder, the persistent current decreases with ξ in the regime of weak disorder but increases in the regime of strong disorder. In addition, it is found that the persistent current in perfect rings decreases exponentially with temperature even at T < T*, while in most disorder rings, the typical current decreases slightly with temperature at T < T*.

  17. Current Trends in Continuous Glucose Monitoring.

    Science.gov (United States)

    Lodwig, Volker; Kulzer, Bernhard; Schnell, Oliver; Heinemann, Lutz

    2014-03-01

    The market introduction of systems for continuous glucose monitoring (CGM) some 15 years ago did not immediately revolutionize the treatment of diabetes; however, for a given group of patients, it would almost be inconceivable nowadays to imagine life without CGM. One day the development of insulin pumps together with CGM could culminate in an artificial pancreas system. The performance of the glucose sensors used for glucose measurement in the interstitial fluid in the subcutaneous tissue and the algorithms employed to analyze these data have improved so much over the past decade that current CGM systems by far outperform those of the first generations. This commentary discusses a number of aspects about what we have learned since CGM systems entered the market and what current trends exist in their usage. Some of these are major hurdles facing a more widespread usage of CGM.

  18. Persistent spin current in nanodevices and definition of the spin current

    Science.gov (United States)

    Sun, Qing-Feng; Xie, X. C.; Wang, Jian

    2008-01-01

    We investigate two closely related subjects: (i) the existence of a pure persistent spin current without an accompanying charge current in a semiconducting mesoscopic device with a spin-orbit interaction (SOI) and (ii) the definition of the spin current in the presence of SOI. Through physical argument from four physical pictures in different aspects, we provide strong evidences that the equilibrium persistent spin current does exist in a device with SOI in the absence of any magnetic field or magnetic materials. This persistent spin current is an analog of the persistent charge current in a mesoscopic ring threaded by a magnetic flux, and it describes the real spin motion and can be measured experimentally. We then investigate the definition of the spin current. We point out that (i) the nonzero spin current in the equilibrium SOI device is the persistent spin current, (ii) the spin current is, in general, not conserved, and (iii) the Onsager relation is violated for the spin transport no matter what definition of the spin current is used. These issues, the nonzero spin current in the equilibrium case, the nonconserved spin current, and the violation of the Onsager relation, are intrinsic properties of spin transport. We note that the conventional definition of the spin current has very clear physical intuition and describes the spin motion very well. Therefore, we feel that the conventional definition of the spin current makes physical sense, and there is no need to modify it. (Note that this conclusion is not in contradiction with the opinions in our previous papers). In addition, the relationship between the persistent spin current and transport spin current, the persistent linear and angular spin currents in the SOI region of the hybrid ring, and the measurement of the persistent spin current are discussed. Finally, we show that if the spin-spin interaction is included into the Hamiltonian, the persistent spin current is automatically conserved using the

  19. Current trends of tropical fruit waste utilization.

    Science.gov (United States)

    Cheok, Choon Yoong; Mohd Adzahan, Noranizan; Abdul Rahman, Russly; Zainal Abedin, Nur Hanani; Hussain, Norhayati; Sulaiman, Rabiha; Chong, Gun Hean

    2016-05-31

    Recent rapid growth of the world's population has increased food demands. This phenomenon poses a great challenge for food manufacturers in maximizing the existing food or plant resources. Nowadays, the recovery of health benefit bioactive compounds from fruit wastes is a research trend not only to help minimize the waste burden, but also to meet the intensive demand from the public for phenolic compounds which are believed to have protective effects against chronic diseases. This review is focused on polyphenolic compounds recovery from tropical fruit wastes and its current trend of utilization. The tropical fruit wastes include in discussion are durian (Durio zibethinus), mangosteen (Garcinia mangostana L.), rambutan (Nephelium lappaceum), mango (Mangifera indica L.), jackfruit (Artocarpus heterophyllus), papaya (Carica papaya), passion fruit (Passiflora edulis), dragon fruit (Hylocereus spp), and pineapple (Ananas comosus). Highlights of bioactive compounds in different parts of a tropical fruit are targeted primarily for food industries as pragmatic references to create novel innovative health enhancement food products. This information is intended to inspire further research ideas in areas that are still under-explored and for food processing manufacturers who would like to minimize wastes as the norm of present day industry (design) objective.

  20. Management of infantile hemangiomas: Current trends

    Directory of Open Access Journals (Sweden)

    Gomathy Sethuraman

    2014-01-01

    Full Text Available Infantile hemangiomas (IH are common vascular tumours. IH have a characteristic natural course. They proliferate rapidly during the early infantile period followed by a period of gradual regression over several years. Most of the uncomplicated IH undergo spontaneous involution, with a small proportion of cases requiring intervention. These are children with IH in life-threatening locations, local complications like haemorrhage, ulceration and necrosis and functional or cosmetic disfigurements. Systemic corticosteroids have been the first line of treatment for many years. Recently, non-selective beta-blockers, such as oral propranalol and topical timolol, have emerged as promising and safer therapies. Other treatment options include interferon α and vincristine which are reserved for life-threatening haemangiomas that are unresponsive to conventional therapy. This review mainly focuses on the current trends and evidence-based approach in the management of IH.

  1. Computational approaches to analogical reasoning current trends

    CERN Document Server

    Richard, Gilles

    2014-01-01

    Analogical reasoning is known as a powerful mode for drawing plausible conclusions and solving problems. It has been the topic of a huge number of works by philosophers, anthropologists, linguists, psychologists, and computer scientists. As such, it has been early studied in artificial intelligence, with a particular renewal of interest in the last decade. The present volume provides a structured view of current research trends on computational approaches to analogical reasoning. It starts with an overview of the field, with an extensive bibliography. The 14 collected contributions cover a large scope of issues. First, the use of analogical proportions and analogies is explained and discussed in various natural language processing problems, as well as in automated deduction. Then, different formal frameworks for handling analogies are presented, dealing with case-based reasoning, heuristic-driven theory projection, commonsense reasoning about incomplete rule bases, logical proportions induced by similarity an...

  2. Current Market Trends Maritime Transport Services

    Directory of Open Access Journals (Sweden)

    Florin Dan Puscaciu

    2011-10-01

    Full Text Available Maritime transport services is a fundamental component of international logistics, given that approximately 80% of world trade is carried by sea. Also, considering the spatial distribution of resources according to the processing sites and disposal of finished goods and the fact that nearly two thirds of the globe is covered by water, has led a Norwegian ship-owner, Erling Næss, to claim that "Divinity has been very generous with ship owners."In the 3rd millennium, when this study was done, there were a number of trends representing some sequels of a prior period and also a series of phenomenon of the current period. We aim to address key market segments of shipping. In order to carry out the graphs and determine the indicators we used Matlab software.

  3. Persistent currents for interacting electrons in ballistic/chaotic billiards

    Science.gov (United States)

    Zelyak, Oleksandr; Murthy, Ganpathy

    2005-03-01

    We study persistent currents in a quantum billiard enclosing a magnetic flux φ by analytical and numerical methods. We concentrate on the family of Robnik-Berry billiards generated by conformal maps of the unit disk. We study the persistent current as a function of magnetic flux and parameters of the billiard in the chaotic regime. We include Fermi-liquid interactions in a mean-field approach, justified by the recent large-N approach[1] for ballistic/chaotic quantum dots. [1] G. Murthy, R. Shankar, D. Herman, and H. Mathur, Phys. Rev. B 69, 075321 (2004); G. Murthy, R. Shankar, and H. Mathur, cond-mat/0411280.

  4. Temperature induced decay of persistent currents in superfluid ultracold gas

    CERN Document Server

    Kumar, Avinash; Jendrzejewski, Fred; Campbell, Gretchen K

    2016-01-01

    We study how temperature affects the lifetime of a quantized, persistent current state in a toroidal Bose-Einstein condensate (BEC). When the temperature is increased, we find a decrease in the persistent current lifetime. Comparing our measured decay rates to simple models of thermal activation and quantum tunneling, we do not find agreement. The measured critical velocity is also found to depend strongly on temperature, approaching the zero temperature mean-field solution as the temperature is decreased. This indicates that an appropriate definition of critical velocity must incorporate the role of thermal fluctuations, something not explicitly contained in traditional theories.

  5. Oscillatory persistent currents in quantum rings: Semiconductors versus superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Devreese, J.T., E-mail: jozef.devreese@ua.ac.b [TFVS, Universiteit Antwerpen, B-2020 Antwerpen (Belgium); COBRA, Eindhoven University of Technology, 5600 MB Eindhoven (Netherlands); Fomin, V.M. [TFVS, Universiteit Antwerpen, B-2020 Antwerpen (Belgium); COBRA, Eindhoven University of Technology, 5600 MB Eindhoven (Netherlands); Dept. of Theoretical Physics, State Univ. of Moldova, MD-2009 Chisinau (Moldova, Republic of); Institute for Integrative Nanosciences, IFW Dresden, D-01069 Dresden (Germany); Gladilin, V.N. [TFVS, Universiteit Antwerpen, B-2020 Antwerpen (Belgium); Dept. of Theoretical Physics, State Univ. of Moldova, MD-2009 Chisinau (Moldova, Republic of); Tempere, J. [TFVS, Universiteit Antwerpen, B-2020 Antwerpen (Belgium); Lyman Laboratory of Physics, Harvard University, Cambridge, MA 02138 (United States)

    2010-10-01

    Persistent currents are a hallmark of superconductivity in metals. To observe those dissipationless currents in a non-superconducting ring, the circumference of the ring must be short enough so that the phase coherence of the electronic wave functions is preserved around the loop. Recent progress in the fabrication of self-assembled semiconductor quantum rings (SAQRs), which can be filled with only a few (1-2) electrons, has offered the unique possibility to study the magnetic-field-induced oscillations in the persistent current carried by a single electron. In this paper, we discuss similarities and distinctions between the behavior of persistent currents in semiconductor and superconductor samples and give an overview of the recent results for oscillatory persistent currents in SAQRs. Although the real SAQR shape differs strongly from an idealized circular-symmetric open ring structure, the Aharonov-Bohm oscillations of the magnetization survive, as observed in low temperature magnetization measurements on In{sub x}Ga{sub 1-x}As/GaAs SAQRs.

  6. Current Trends in the Management of Retinoblastoma

    Directory of Open Access Journals (Sweden)

    Hayyam Kıratlı

    2014-09-01

    Full Text Available Retinoblastoma is the most common primary intraocular malignant tumor of early childhood, and 95% of all cases are diagnosed before the age of 5 years. Tumors are evaluated and classified based on laterality, genetic features, the number, location and size of foci. Currently, systemic and intaarterial chemotherapy are the most commonly used management options worldwide. Group A tumors are treated with focal techniques including transpupillary thermotherapy, cryotherapy, or laser photocoagulation. Groups B and C tumors are managed with systemic chemotherapy and focal consolidation techniques. Group D lesions are best treated with systemic chemotherapy, subtenon carboplatin injection or external beam radiotherapy. Alternatively, groups B, C and D tumors can be primarily treated with intraarterial chemotherapy. Intravitreal melphalan injection can be an alternative treatment for eyes with recurrent or persistent vitreous seeding. Group E eyes are often enucleated, however, depending on the fellow eye, systemic or intraarterial chemotherapy may be administered. Systemic chemotherapy is also mandatory if high-risk histopathological features are found after enucleation. (Turk J Ophthalmol 2014; 44: Supplement 22-8

  7. Persistent spin and mass currents and Aharonov-Casher effect

    OpenAIRE

    Balatsky, A. V.; Altshuler, B.L.

    1992-01-01

    Spin-orbit interaction produces persistent spin and mass currents in the ring via the Aharonov-Casher effect. The experiment in $^3He-A_1$ phase, in which this effect leads to the excitation of mass and spin supercurrent is proposed.

  8. Cholangiocarcinoma:principles and current trends

    Institute of Scientific and Technical Information of China (English)

    George N Zografos; Athanasios Farfaras; Flora Zagouri; Dimosthenis Chrysikos; Kostas Karaliotas

    2011-01-01

    BACKGROUND: Cholangiocarcinoma (CCA) is a lethal cancer ofthebiliaryepithelium,originatingfromtheliver(intrahepatic), at the confluence of the right and left hepatic ducts (hilar) or in the extrahepatic bile ducts. It is a rare malignancy associated with poor prognosis. DATA SOURCES: WesearchedthePubMed/MEDLINEdatabase for relevant articles published from 1989 to 2008. The search terms used were related to "cholangiocarcinoma" and its"treatment". Although no language restrictions were imposed initially, for the full-text review and final analysis, our resources only permitted the review of articles published in English. This review deals with the treatment of cholangiocarcinoma, the principles and the current trends. RESULTS:  The risks and prognostic factors, symptoms and differential diagnosis are thoroughly discussed. In addition, the tools of preoperative diagnosis such as endoscopic retrograde cholangiopancreatography, digital image analysis, fluorescence in situ hybridization and magnetic resonance cholangiopancreatography are reviewed. Moreover, the treatment of CCA is discussed. CONCLUSIONS: The only curative treatment available is surgical management. Unfortunately, many patients present with unresectable tumors, the majority of whom die within a year of diagnosis. Surgical treatment involves major resections of the liver, pancreas and bile duct, with considerable mortality and morbidity. However, in selected cases and where indicated, appropriate management with aggressive surgery may achieve a good outcome with a prolonged survival expectancy.

  9. Common Stochastic Trends in the Current Account

    NARCIS (Netherlands)

    Kumah, F.Y.

    1996-01-01

    Solow residuals are used as proxies for productivity shocks in many empirical studies.Considering the shortcomings of this approach this paper proposes the common trends approach as an alternative.The common trends econometric technique is utilized here in an attempt to identify and analyze the long

  10. Drafting: Current Trends and Future Practices

    Science.gov (United States)

    Jensen, C.

    1976-01-01

    Various research findings are reported on drafting trends which the author feels should be incorporated into teaching drafting: (1) true position and geometric tolerancing, (2) decimal and metric dimensioning, (3) functional drafting, (4) automated drafting, and (5) drawing reproductions. (BP)

  11. A Magnetic Persistent Current Switch at milliKelvin Temperatures

    CERN Document Server

    van Waarde, Bob; Oosterkamp, Tjerk

    2016-01-01

    We report the development of a magnetically driven Persistent Current Switch operated in a dilution refrigerator. We show that it can be safely used to charge a 60 mH coil with 0.5 A at 11 mK, which heats up the dilution refrigerator to 60.5 mK. Measurements at 4 K on a 440 $\\mu$H coil reveal a residual resistance of $R \\leqslant 3.3$ p$\\Omega$.

  12. A PERSISTING SECULAR TREND FOR BODY MEASUREMENTS IN DUTCH CHILDREN - THE OOSTERWOLDE-II STUDY

    NARCIS (Netherlands)

    GERVER, WJM; DEBRUIN, R; DRAYER, NM

    1994-01-01

    To investigate whether the secular trend for growth in Dutch children still exists, the Oosterwolde I study of 1980 was repeated in 1989. A persisting secular trend was visible for height while the z scores of body proportions show no change during the past 10 years, which suggests that there is no

  13. Current Trends in Nuclear and Radiation Sensing

    Energy Technology Data Exchange (ETDEWEB)

    Harold R. McHugh and William Quam

    2009-05-01

    This paper provides a brief overview of radiation detector history, a summary of the present state of the art, and some speculation on future developments in this field. Trends in the development of radiation detectors over the years are analyzed. Rapid progress in detection technology was experienced between WWII and the 1970s. Since then, fewer dramatic improvements have been seen. The authors speculate about the reasons for this trend and where the technology might take us in the next 20 years. Requirements for radiation detection equipment have changed drastically since 9/11; this demand is likely to accelerate detector development in the near future.

  14. Current trends in free software research

    OpenAIRE

    Navarro Bosch, Ramon; Vila Marta, Sebastià

    2009-01-01

    This report analyzes how scientific research is studying free software. We find which research is being done on free software by looking into scientific journals and conferences publications. The data thus obtained is analized and the most salient trends related to free software discovered. We also reviewed the main works published in each free software research area.

  15. Obesity in Nigeria: Current trends and management | Akpa ...

    African Journals Online (AJOL)

    Obesity in Nigeria: Current trends and management. ... The objective of the study is to review the current knowledge on the problems associated with obesity, ... of obesity, its epidemiology, risk factors, clinical complications and treatment ...

  16. Recommendations for Evaluating Temporal Trends of Persistent Organic Pollutants in Breast Milk.

    Science.gov (United States)

    Gyalpo, Tenzing; Scheringer, Martin; Hungerbühler, Konrad

    2016-07-01

    Biomonitoring data of persistent organic pollutants (POPs) in breast milk are increasingly collected and available for quantitative analysis of levels and time trends. A common approach is to apply log-linear regression to calculate doubling and halving times of the POP concentrations based on the temporal trend observed in breast milk. However, there are different, sometimes conflicting interpretations of these doubling and halving times. We provide a mechanistic understanding of doubling and halving times where possible. Five recommendations are proposed for dealing with POP concentration trends in breast milk during three distinct periods (pre-ban, transition, post-ban period). Using temporal trends of BDE-47 and PCB-153 in breast milk data, we show which information can be gained from the time-trend data. To this end, we analyzed time trends of hypothetical POPs for different periods with time-variant exposure and different intrinsic elimination half-lives, using a dynamic population-based pharmacokinetic model. Different pieces of information can be extracted from time-trend data from different periods. The analysis of trends of short-lived POPs is rather straightforward and facilitates extraction of the intrinsic elimination half-lives from the breast milk data. However, trends of slowly eliminated POPs only provide indications for the exposure time trend. Time-trend data of rapidly eliminated POPs provide information on exposure time trends and elimination half-lives. Temporal trends of slowly eliminated POPs are more complicated to interpret, and the extraction of exposure time trends and elimination half-lives require data sets covering several decades. Gyalpo T, Scheringer M, Hungerbühler K. 2016. Recommendations for evaluating temporal trends of persistent organic pollutants in breast milk. Environ Health Perspect 124:881-885; http://dx.doi.org/10.1289/ehp.1510219.

  17. Sustainable Biomaterials: Current Trends, Challenges and Applications

    Directory of Open Access Journals (Sweden)

    Girish Kumar Gupta

    2015-12-01

    Full Text Available Biomaterials and sustainable resources are two complementary terms supporting the development of new sustainable emerging processes. In this context, many interdisciplinary approaches including biomass waste valorization and proper usage of green technologies, etc., were brought forward to tackle future challenges pertaining to declining fossil resources, energy conservation, and related environmental issues. The implementation of these approaches impels its potential effect on the economy of particular countries and also reduces unnecessary overburden on the environment. This contribution aims to provide an overview of some of the most recent trends, challenges, and applications in the field of biomaterials derived from sustainable resources.

  18. Sustainable Biomaterials: Current Trends, Challenges and Applications.

    Science.gov (United States)

    Kumar Gupta, Girish; De, Sudipta; Franco, Ana; Balu, Alina Mariana; Luque, Rafael

    2015-12-30

    Biomaterials and sustainable resources are two complementary terms supporting the development of new sustainable emerging processes. In this context, many interdisciplinary approaches including biomass waste valorization and proper usage of green technologies, etc., were brought forward to tackle future challenges pertaining to declining fossil resources, energy conservation, and related environmental issues. The implementation of these approaches impels its potential effect on the economy of particular countries and also reduces unnecessary overburden on the environment. This contribution aims to provide an overview of some of the most recent trends, challenges, and applications in the field of biomaterials derived from sustainable resources.

  19. Period Halving of Persistent Currents in Mesoscopic Mobius Ladders

    Institute of Scientific and Technical Information of China (English)

    邓文基; 许基桓; 刘平

    2002-01-01

    We investigate the period halving of persistent currents (PCs) of non-interacting electrons in isolated mesoscopicMobius ladders without disorder, pierced by Aharonov-Bohm flux. The mechanisms of the period halving effectdepend on the parity of the number of electrons as well as on the interchain hopping. Although the data of PCsin mesoscopic systems are sample specific, some simple rules are found in the canonical ensemble average, forexample, all the odd harmonics of the PCs disappear and the signals of even harmonics are non-negative.

  20. Trends in medical employment: persistent imbalances in urban Mexico.

    Science.gov (United States)

    Frenk, J; Knaul, F M; Vázquez-Segovia, L A; Nigenda, G

    1999-01-01

    OBJECTIVES: This study examined the extreme medical unemployment and underemployment in the urban areas of Mexico. The conceptual and methodological approach may be relevant to many countries that have experienced substantial increases in the supply of physicians during the last decades. METHODS: On the basis of 2 surveys carried out in 1986 and 1993, the study analyzed the performance of physicians in the labor market as a function of ascription variables (social origin and gender), achievement variables (quality of medical education and specialty studies), and contextual variables (educational generation). RESULTS: The study reveals, despite some improvement, persistently high levels of open unemployment, qualitative underemployment (i.e., work in activities completely outside of medicine), and quantitative underemployment (i.e., work in medical activities but with very low levels of productivity and remuneration). The growing proportion of female doctors presents new challenges, because they are more likely than men to be unemployed and underemployed. CONCLUSIONS: While corrective policies can have a positive impact, it is clear that decisions regarding physician supply must be carefully considered, because they have long-lasting effects. An area deserving special attention is the improvement of professional opportunities for female doctors. PMID:10394315

  1. Employee Training: Current Trends, Future Challenges.

    Science.gov (United States)

    Gorovitz, Elizabeth

    1983-01-01

    Issues currently affecting employee training are the impact of high technology, worker adaptability, the communications revolution, job satisfaction, underinvestment in human capital, demographic shifts, and interest in productivity improvement. (SK)

  2. Current trends in Irish perinatal mortality.

    LENUS (Irish Health Repository)

    Mahony, R

    2010-06-01

    This was a retrospective review of normally formed perinatal deaths among 176,620 births at the National Maternity Hospital (1984-2007). Prelabor stillbirths were categorised by presumed cause of death including unexplained, intrauterine growth retardation (IUGR), placental abruption, red cell alloimmunisation (RCA) and deaths related to prematurity. Peripartum deaths included intrapartum and first week neonatal deaths. The post-mortem rate, initially almost 100%, fell to 60%. Data were analysed using the Mantel-Haenszel chi square test for trends. In the study period there was a significant reduction in the PNM, largely because of a fall in death related to prematurity, term peripartum death, death at 42 weeks or greater, placental abruption, death related to IUGR and RCA (P < 0.01). Overall the unexplained still birth rate was unchanged throughout the study period (p = 0.8) despite a highly significant (p < 0.001) increase in obstetric intervention particularly induction of labor and caesarean section.

  3. Current trends in chloroplast genome research

    African Journals Online (AJOL)

    USER

    2010-06-14

    Jun 14, 2010 ... organization and promising ability for transgenic expression. Therefore, cpDNA ... highly conserved in size, structure and gene content. (Olmstead and ... contain only 10% of the genes required for fully functional organelle whereas the ... concept (McFadden, 1999; Maliga, 2003; Howe, 2008). Currently 170 ...

  4. Current trends in robotic surgery for otolaryngology.

    Science.gov (United States)

    Byrd, J Kenneth; Duvvuri, Umamaheswar

    2013-09-01

    As minimally invasive surgery has become common in head and neck surgery, the role of robotic surgery has expanded from thyroid surgery and transoral robotic surgery (TORS) of the oropharynx and supraglottic to other areas. Surgeons have advanced the limits of TORS, adapting lasers to the Da Vinci robot for glottic cancer, and combining existing techniques for transoral supraglottic laryngectomy and hypopharyngectomy to perform transoral total laryngectomy. Skull base approaches have been reported with some success in case reports and cadaver models, but the current instrument size and configuration limit the applicability of the current robotic system. Surgeons have reported reconstruction of the head and neck via local and free flaps. Using the previously reported approaches for thyroidectomy via modified facelift incision, neck dissection has also been reported. Future applications of robotic surgery in otolaryngology may be additionally expanded, as several new robotic technologies are under development for endolaryngeal work and neurotology.

  5. Current Trends in Wireless Sensor Network Design

    OpenAIRE

    Neha Jain; Agrawal, Dharma P.

    2005-01-01

    The self-organizing nature of sensor networks, their autonomous operation and potential architectural alternatives make them suitable for different data-centric applications. Their wider acceptance seems to be rising on the horizon. In this article, we present an overview of the current state of the art in the field of wireless sensor networks. We also present various open research issues and provide an insight about the latest developments that need to be explored in greater depth that could...

  6. Changing trends and persisting biases in three decades of conservation science

    Directory of Open Access Journals (Sweden)

    Moreno Di Marco

    2017-04-01

    Full Text Available Conservation science is a rapidly developing discipline, and the knowledge base it generates is relevant for practical applications. It is therefore crucial to monitor biases and trends in conservation literature, to track the progress of the discipline and re-align efforts where needed. We evaluated past and present trends in the focus of the conservation literature, and how they relate to conservation needs. We defined the focus of the past literature from 13 published reviews referring to 18,369 article classifications, and the focus of the current literature by analysing 2553 articles published between 2011–2015. We found that some of the historically under-studied biodiversity elements are receiving significantly more attention today, despite being still under-represented. The total proportion of articles on invertebrates, genetic diversity, or aquatic systems is 50%–60% higher today than it was before 2010. However, a disconnect between scientific focus and conservation needs is still present, with greater attention devoted to areas or taxa less rich in biodiversity and threatened biodiversity. In particular, a strong geographical bias persists, with 40% of studies carried out in USA, Australia or the UK, and only 10% and 6% respectively in Africa or South East Asia. Despite some changing trends, global conservation science is still poorly aligned with biodiversity distribution and conservation priorities, especially in relation to threatened species. To overcome the biases identified here, scientists, funding agencies and journals must prioritise research adaptively, based on biodiversity conservation needs. Conservation depends on policy makers and practitioners for success, and scientists should actively provide those who make decisions with the knowledge that best addresses their needs.

  7. Sensing technology current status and future trends

    CERN Document Server

    Mukhopadhyay, Subhas; Jayasundera, Krishanthi; Bhattacharyya, Nabarun

    2014-01-01

    This book is written for academic and industry professionals working in the field of sensing, instrumentation and related fields, and is positioned to give a snapshot of the current state of the art in sensing technology, particularly from the applied perspective.  The book is intended to give a broad overview of the latest developments, in addition to discussing the process through which researchers go through in order to develop sensors, or related systems, which will become more widespread in the future.  

  8. CURRENT TRENDS IN THE FOREIGN TRADE

    Directory of Open Access Journals (Sweden)

    Florin Alexandru LUCA

    2014-11-01

    Full Text Available In this article, we aim at highlighting the benefits of international trade on economic growth and development. In the first part of the paper, we will outline the seminal theories in the doctrine of international trade. In the second part, we will focus on current developments in the exports and imports of goods and services. We will also consider several indicators meant to emphasize the various aspects of research. Our approach is a transversal-comparative one and static models pertain to uni- and multivariate analysis.

  9. Persistent current in an almost staggered Harper model

    Science.gov (United States)

    Vasserman, A.; Berkovits, R.

    2015-08-01

    In this paper we study the persistent current (PC) of a staggered Harper model, close to the half-filling. The Harper model is different than other one dimensional disordered systems which are always localized, since it is a quasi-periodic system with correlated disorder resulting in the fact that it can be in the metallic regime. Nevertheless, the PC for a wide range of parameters of the Harper model does not show typical metallic behavior, although the system is in the metallic regime. This is a result of the nature of the central band states, which are a hybridization of Gaussian states localized in superlattice points. When the superlattice is not commensurate with the system length, the PC behaves as an insulator. Thus even in the metallic regime a typical finite Harper model may exhibit a PC expected from an insulator.

  10. Solar photovoltaics: current state and trends

    Science.gov (United States)

    Milichko, V. A.; Shalin, A. S.; Mukhin, I. S.; Kovrov, A. E.; Krasilin, A. A.; Vinogradov, A. V.; Belov, P. A.; Simovski, C. R.

    2016-08-01

    Basic aspects of current solar photovoltaics (PVs) are reviewed, starting from the recently developed already-on-the-market first-generation solar cells and ending with promising but not yet commercialized third-generation cells and materials possibly leading to new cell designs. The emphasis is on the physical principles of operation of various solar cells, which are divided into several groups according to our classification scheme. To make the picture complete, some technological and economic aspects of the field are discussed. A separate chapter considers antireflection coatings and light-trapping textures — structures which, while not having appeared yet in the PV review literature, are an integral part of the solar cells.

  11. Current Trends in Computer-Based Education in Medicine

    Science.gov (United States)

    Farquhar, Barbara B.; Votaw, Robert G.

    1978-01-01

    Important current trends in the use of computer technology to enhance medical education are reported in the areas of simulation and assessment of clinical competence, curriculum integration, financial support, and means of exchanging views and scientific information. (RAO)

  12. Current trends in high temperature design

    Energy Technology Data Exchange (ETDEWEB)

    Marriott, D.L. (Illinois Univ., Urbana, IL (United States). Dept. of Mechanical Engineering)

    1992-01-01

    A review of high temperature design guidelines has been carried out in preparation for designing a solar storage module for the Freedom Spacelab. Three major guidelines, N47, R5 and RCC-MR form the basis of the survey. The main issues with current, mature design in the power industry appear to be adequately covered by these guidelines. A significant finding is that long established models of material damage have survived the test of time very well. A new design regime referred to as Very High Temperature Design (VHTD) is identified. The characteristics of this regime are changing material properties which require some changes in philosophy in drafting of future codes, particularly in regard to definitions of yield strengths and other design allowables. Finally, there is some discussion of the more general use of the stress/strain plane, e.g. isochronous curves, for representation of very complex material constitutive behaviour. A concept called the 'Relaxation Locus', which summarizes essential local constrained component behavior, is introduced and its application to high temperature design problems is discussed briefly. (author).

  13. Current trends to measure implant stability.

    Science.gov (United States)

    Swami, Vasanthi; Vijayaraghavan, Vasantha; Swami, Vinit

    2016-01-01

    Implant stability plays a critical role for successful osseointegration. Successful osseointegration is a prerequisite for functional dental implants. Continuous monitoring in an objective and qualitative manner is important to determine the status of implant stability. Implant stability is measured at two different stages: Primary and secondary. Primary stability comes from mechanical engagement with cortical bone. Secondary stability is developed from regeneration and remodeling of the bone and tissue around the implant after insertion and affected by the primary stability, bone formation and remodelling. The time of functional loading is dependent upon the implant stability. Historically the gold standard method to evaluate stability were microscopic or histologic analysis, radiographs, however due to invasiveness of these methods and related ethical issues various other methods have been proposed like cutting torque resistance, reverse torque analysis, model analysis etc. It is, therefore, of an utmost importance to be able to access implant stability at various time points and to project a long term prognosis for successful therapy. Therefore this review focuses on the currently available methods for evaluation of implant stability.

  14. CURRENT TRENDS IN PULSATILE DRUG DELIVERY SYSTEMS

    Directory of Open Access Journals (Sweden)

    S. R. Tajane et al.

    2012-01-01

    Full Text Available The purpose for this review on pulsatile drug delivery systems (PDDS is to compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation. Pulsatile drug delivery system is the most interesting time and site-specific system. This system is designed for chronopharmacotherapy. Thus, to mimic the function of living systems and in view of emerging chronotherapeutic approaches, pulsatile delivery, which is meant to release a drug following programmed lag phase, has increasing interest in the recent years. Diseases wherein PDDS are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, and attention deficit syndrome in children, cancer, diabetes, and hypercholesterolemia. Pulsatile drug delivery system divided into 2 types’ preplanned systems and stimulus induced system, preplanned systems based on osmosis, rupturable layers, and erodible barrier coatings. Stimuli induced system based on electrical, temperature and chemically induced systems. This review also summarizes some current PDDS already available in the market. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

  15. Tuberculosis: current trends in diagnosis and treatment.

    Science.gov (United States)

    Bello, A K; Njoku, C H; Njoku, A K

    2005-12-01

    Among communicable diseases, tuberculosis (TB) is the second leading cause of death worldwide, killing nearly 2 million people each year. It is estimated that about one-third of the world population are infected with TB (2 billion people) and about 10% of this figure will progress to disease state. Most cases are in the less-developed countries of the world. Tuberculosis incidence has been on the increase in Africa, mainly as a result of the burden of HIV infection. Definitive diagnosis of tuberculosis remains based on culture for Mycobacterium tuberculosis, but rapid diagnosis of infectious tuberculosis by simple sputum smear for acid fast bacilli remains an important tool, as more rapid molecular techniques are being developed. Treatment with several drugs for 6 months or more can cure more than 95% of patients. Direct observation of treatment, a component of the recommended five-element DOTS strategy, is judged to be the standard of care by most authorities. Currently only a third of cases worldwide are treated using this approach. There may be need to modify the treatment modalities especially with the choice of drugs and duration of therapy when TB infection occurs in special situation like pregnancy, liver disease, renal failure or even in coexistence with HlV/AIDS or the drug resistant state.

  16. Exploring Managerial Implications of Current DoD Contracting Trends

    Science.gov (United States)

    2014-05-15

    Managerial Implications of Current DoD Contracting Trends Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the...SUBTITLE Exploring Managerial Implications of Current DoD Contracting Trends 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...COMMUNICATION − Transparent − Information Sharing − Publish Best Practices & Strategic Sourcing Methods • INDUSTRY − Outreach − Economic Impacts

  17. Current trends in staging rectal cancer

    Institute of Scientific and Technical Information of China (English)

    Abdus Samee; Chelliah Ramachandran Selvasekar

    2011-01-01

    Management of rectal cancer has evolved over the years.In this condition preoperative investigations assist in deciding the optimal treatment.The relation of the tumor edge to the circumferential margin (CRM) is an important factor in deciding the need for neoadjuvant treatment and determines the prognosis.Those with threatened or involved margins are offered long course chemoradiation to enable R0 surgical resection.Endoanal ultrasound (EUS) is useful for tumor (T) staging;hence EUS is a useful imaging modality for early rectal cancer.Magnetic resonance imaging (MRI) is useful for assessing the mesorectum and the mesorectal fascia which has useful prognostic significance and for early identification of local recurrence.Computerized tomography (CT) of the chest,abdomen and pelvis is used to rule out distant metastasis.Identification of the malignant nodes using EUS,CT and MRI is based on the size,morphology and internal characteristics but has drawbacks.Most of the common imaging techniques are suboptimal for imaging following chemoradiation as they struggle to differentiate fibrotic changes and tumor.In this situation,EUS and MRI may provide complementary information to decide further treatment.Functional imaging using positron emission tomography (PET) is useful,particularly PET/CT fusion scans to identify areas of the functionally hot spots.In the current state,imaging has enabled the multidisciplinary team of surgeons,oncologists,radiologists and pathologists to decide on the patient centered management of rectal cancer.In future,functional imaging may play an active role in identifying patients with lymph node metastasis and those with residual and recurrent disease following neoadjuvant chemoradiotherapy.

  18. Current trends with natural language processing.

    Science.gov (United States)

    Rassinoux, A M; Michel, P A; Wagner, J; Baud, R

    1995-01-01

    Natural Language Processing in the medical domain becomes more and more powerful, efficient, and ready to be used in daily practice. The needs for such tools are enormous in the medical field, due to the vast amount of written texts for medical records. In the authors' point of view, the Electronic Patient Record (EPR) is achieved neither with Information Systems of all kinds nor with commercially available word processing systems. Natural Language Processing (NLP) is one dimension of the EPR, as well as Image Processing and Decision Support Systems. Analysis of medical texts to facilitate indexing and retrieval is well known. The need for a generation tool is to produce progress notes from menu driven systems. The computer systems of tomorrow cannot miss any single dimension. Since 1988, we've been developing an NLP system; it is supported by the European program AIM (Advanced Informatics in Medicine) within the GALEN and HELIOS consortium and the CERS (Commission d'Encouragement á la Recherche Scientifique) in Switzerland. The main directions of development are: a medical language analyzer, a language generator, a query processor, and dictionary building tools to support the Medical Linguistic Knowledge Base (MLKB). The knowledge representation schema is essentially based on Sowa's conceptual graphs, and the MLKB is multilingual from its design phase; it currently incorporates the English and the French languages; it will also continue using German. The goal of this demonstration is to provide evidence of what exists today, what will be soon available, and what is planned for the long term. Complete sentences will be processed in real time, and the browsing capabilities of the MLKB will be exercised. In particular, the following features will be presented: Analysis of complete sentences with verbs and relatives, as extracted from clinical narratives, with special attention to the method of "proximity processing" as developed in our group and the rule based

  19. Experimental Study on Current Decay Characteristics of Persistent Current HTS Magnet by Alternating Magnetic Field

    Science.gov (United States)

    Park, Young Gun; Lee, Chang Young; Hwang, Young Jin; Lee, Woo Seung; Lee, Jiho; Jo, Hyun Chul; Chung, Yoon Do; Ko, Tae Kuk

    This paper deals with a current decay characteristics of a high temperature superconducting (HTS) magnet operated in persistent current mode (PCM). In superconducting synchronous machine applications such as linear synchronous motor (LSM), the superconducting coil is designed to operate in the PCM to obtain steady magnetic field with DC transport current. This superconducting magnet operates on a direct current, but it can be exposed to alternating magnetic field due to the armature winding. When the magnet is subjected to an external time-varying magnetic field, it is possible to result in a decay of the current in PCM system due to AC loss. In this research, a PCM system with armature coil which generates time-varying magnetic field was fabricated to verify current decay characteristics by external alternating magnetic field. The current decay rate was measured by using a hall sensor as functions of amplitude and frequency of armature coil.

  20. Persistent Currents in the Double Aharonov-Bohm Ring Connected to Electron Reservoirs

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ying; XIAO Jing-Lin

    2007-01-01

    We study persistent currents in the double Aharonov-Bohm ring connected to two electron reservoirs by quantum waveguide theory. It is found that the persistent currents in the double Aharonov-Bohm ring depend on the direction of the current flow from one reservoir to another. When the direction of the current flow reverses, the persistent current in each ring of the double Aharonov-Bohm ring changes. If the two rings are of the same size, the persistent currents in the left and the right rings exchange at the reversal of the current flow direction.

  1. Current Trends in Nursing Informatics: Results of an International Survey.

    Science.gov (United States)

    Peltonen, Laura-Maria; Alhuwail, Dari; Ali, Samira; Badger, Martha K; Eler, Gabrielle Jacklin; Georgsson, Mattias; Islam, Tasneem; Jeon, Eunjoo; Jung, Hyunggu; Kuo, Chiu-Hsiang; Lewis, Adrienne; Pruinelli, Lisiane; Ronquillo, Charlene; Sarmiento, Raymond Francis; Sommer, Janine; Tayaben, Jude L; Topaz, Maxim

    2016-01-01

    Nursing informatics (NI) can help provide effective and safe healthcare. This study aimed to describe current research trends in NI. In the summer 2015, the IMIA-NI Students Working Group created and distributed an online international survey of the current NI trends. A total of 402 responses were submitted from 44 countries. We identified a top five NI research areas: standardized terminologies, mobile health, clinical decision support, patient safety and big data research. NI research funding was considered to be difficult to acquire by the respondents. Overall, current NI research on education, clinical practice, administration and theory is still scarce, with theory being the least common. Further research is needed to explain the impact of these trends and the needs from clinical practice.

  2. Localized persistent spin currents in defect-free quasiperiodic rings with Aharonov–Casher effect

    Energy Technology Data Exchange (ETDEWEB)

    Qiu, R.Z.; Chen, C.H.; Cheng, Y.H.; Hsueh, W.J., E-mail: hsuehwj@ntu.edu.tw

    2015-06-26

    We propose strongly localized persistent spin current in one-dimensional defect-free quasiperiodic Thue–Morse rings with Aharonov–Casher effect. The results show that the characteristics of these localized persistent currents depend not only on the radius filling factor, but also on the strength of the spin–orbit interaction. The maximum persistent spin currents in systems always appear in the ring near the middle position of the system array whether or not the Thue–Morse rings array is symmetrical. The magnitude of the persistent currents is proportional to the sharpness of the resonance peak, which is dependent on the bandwidth of the allowed band in the band structure. The maximum persistent spin currents also increase exponentially as the generation order of the system increases. - Highlights: • Strongly localized persistent spin current in quasiperiodic AC rings is proposed. • Localized persistent spin currents are much larger than those produced by traditional mesoscopic rings. • Characteristics of the localized persistent currents depend on the radius filling factor and SOI strength. • The maximum persistent current increases exponentially with the system order. • The magnitude of the persistent currents is related to the sharpness of the resonance.

  3. Distance Education Programs in Social Work: Current and Emerging Trends

    Science.gov (United States)

    Vernon, Robert; Vakalahi, Halaevalu; Pierce, Dean; Pittman-Munke, Peggy; Adkins, Lynn Frantz

    2009-01-01

    This article reports on current and emerging trends in the use of distance education technologies in social work education. Areas studied include the extent of distance education programs, curricular areas covered, technologies used, pedagogical approaches, intentions for degree-program development, sources of pressure to adopt distance education…

  4. Current Technology Trends for School Library Media Specialists

    OpenAIRE

    Leticia Ekhaml; Joan Hubbard

    2003-01-01

    An overview of some of the current technology trends used in classroom instruction and school library media centers in provided in this article such as the use of handheld electronic organizers, CD recorders, digital video cameras, and interactive whiteboards. The article offers some suggestions or ideas on how to acquire new technologies to school library media centers that are low in budgetary funds.

  5. Counseling in Malaysia: History, Current Status, and Future Trends

    Science.gov (United States)

    See, Ching Mey; Ng, Kok-Mun

    2010-01-01

    This article presents an overview of the history of counseling in Malaysia, provides an update of its current status, and discusses some anticipated future trends for the profession in light of recent developments in the country. Counseling in Malaysia began with school guidance in the 1960s and has now achieved recognition as a profession in…

  6. European regional populations: current trends, future pathways and policy options

    NARCIS (Netherlands)

    Rees, P.H.; van der Gaag, N.L.; de Beer, J.A.A.; Heins, F.

    2012-01-01

    Europe is currently experiencing an ageing population and slowing population growth of both the total and working-age populations. These trends are likely to continue. Even though population ageing will affect all European regions, different regions will be affected in different ways. Even under

  7. Five Aspects of Current Trends in German Library Science

    Science.gov (United States)

    Steierwald, Ulrike

    2006-01-01

    The specialisation Library Science at the Hochschule Darmstadt/University of Applied Science Darmstadt is the newest academic program in Germany for the higher education of librarians. Five current trends in library science in Germany reflect the new "Darmstadt Model": (1) The delimitation of a specific professional field…

  8. Five Aspects of Current Trends in German Library Science

    Science.gov (United States)

    Steierwald, Ulrike

    2006-01-01

    The specialisation Library Science at the Hochschule Darmstadt/University of Applied Science Darmstadt is the newest academic program in Germany for the higher education of librarians. Five current trends in library science in Germany reflect the new "Darmstadt Model": (1) The delimitation of a specific professional field "library" is obsolete, so…

  9. Current Trends in Treatment Outcomes of Orbital Cellulitis in a ...

    African Journals Online (AJOL)

    The aim of this study is to determine the current trends in the outcomes following the management of orbital cellulitis at the. University of Benin ... the Statistical Package for Social Sciences Version 21 software program (SPSS Inc. .... or periocular surgery, dental infection, otitis media, dacryocystitis, and endophthalmitis.

  10. Lifelong Education in Greece: Recent Developments and Current Trends

    Science.gov (United States)

    Karalis, Thanassis; Vergidis, Dimitris

    2004-01-01

    This article concerns recent developments and current trends in lifelong education in Greece, specifically those related with funding from European Social Fund (ESF). The analysis undertaken focuses mainly on (a) the expansion of continuing training activities in Greece during the past ten years and the development of new training organizations as…

  11. Educational Research in Mainland China: Current Situation and Developmental Trends

    Science.gov (United States)

    Sun, Miantao

    2011-01-01

    The influence of Confucian culture in Chinese Mainland China is reflected in the current situation and contextual trends of educational research content of educational thought of Confucianism, educational issues grounded on theoretical views of Confucianism, and the influence of the inclusiveness of Confucianism. In terms of research method, the…

  12. Educational Research in Mainland China: Current Situation and Developmental Trends

    Science.gov (United States)

    Sun, Miantao

    2011-01-01

    The influence of Confucian culture in Chinese Mainland China is reflected in the current situation and contextual trends of educational research content of educational thought of Confucianism, educational issues grounded on theoretical views of Confucianism, and the influence of the inclusiveness of Confucianism. In terms of research method, the…

  13. Persistent current of relativistic electrons on a Dirac ring in presence of impurities

    KAUST Repository

    Ghosh, Sumit

    2014-08-01

    We study the behaviour of persistent current of relativistic electrons on a one dimensional ring in presence of attractive/repulsive scattering potentials. In particular, we investigate the persistent current in accordance with the strength as well as the number of the scattering potential. We find that in presence of single scatterer the persistent current becomes smaller in magnitude than the scattering free scenario. This behaviour is similar to the non-relativistic case. Even for a very strong scattering potential, finite amount of persistent current remains for a relativistic ring. In presence of multiple scatterer we observe that the persistent current is maximum when the scatterers are placed uniformly compared to the current averaged over random configurations. However if we increase the number of scatterers, we find that the random averaged current increases with the number of scatterers. The latter behaviour is in contrast to the non-relativistic case. © 2014 EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg.

  14. Modified Bean Model and FEM Method Combined for Persistent Current Calculation in Superconducting Coils

    CERN Document Server

    Völlinger, Christine; Russenschuck, Stephan

    2001-01-01

    Field variations in the LHC superconducting magnets, e. g. during the ramping of the magnets, induce magnetization currents in the superconducting material, the so-called persistent currents that do not decay but persist due to the lack of resistivity. This paper describes a semi-analytical hysteresis model for hard superconductors, which has been developed for the computation of the total field errors arising from persistent currents. Since the superconducting coil is surrounded by a ferromagnetic yoke structure, the persistent current model is combined with the finite element method (FEM), as the non-linear yoke can only be calculated numerically. The used finite element method is based on a reduced vector potential formulation that avoids the meshing of the coil while calculating the part of the field arising from the source currents by means of the Biot-Savart Law. The combination allows to determine persistent current induced field errors as function of the excitation and for arbitrarily shaped iron yoke...

  15. Current Trend in Furnace Technology in the Melting Industries

    Directory of Open Access Journals (Sweden)

    O.A. Ighodalo

    2011-06-01

    Full Text Available The aim of this study is to presents some of the current trend in Furnace technology as it pertains to the melting industries. Furnaces are applied in various industries for material processing. Large amounts of energy are usually consumed in the melting industries. The current trend in furnace technology is towards energy conservation, enhanced efficiency and productivity. The reduction of pollutant emissions are also taken into consideration due to their environmental impact. The various materials and processes for furnaces are discussed. The various strategies being employed towards furnace energy conservation, efficiency and productivity, and reduction of pollutant emissions are also discussed. Such strategies include the use of better fuel types such as natural gas; improved insulation and refractory materials; advanced burner designs such as high velocity, regenerative and recuperative burners; new combustion technologies such as air and fuel staging, flue gas recirculation technique. Mathematical modeling is also being employed for analysis and design purpose.

  16. Current trends in health facility planning, design, and construction.

    Science.gov (United States)

    Beale, Craig; Kittredge, Frank D

    2014-01-01

    It is critical now more than ever for today's healthcare facilities to serve as more than just a backdrop to the care provided--they can, and should, be an integral part of that care. In addition to promoting efficacy, delighting the senses, and placing patients and families at ease, facilities need to be high-performing, sustainable, and healthy environments. Creating today's healthcare facilities requires breaking through barriers in unexpected ways, and it often requires looking outside the healthcare profession for guidance. In this article, we explore current trends in health facility planning, design, and construction. Our focus is on the buildings that serve as venues for the provision of healthcare services across the full continuum, from prevention to critical care. In particular, we discuss four current broad trends and conclude with thoughts on future developments.

  17. Current and future technological trends in positron emission tomography.

    Science.gov (United States)

    Karp, J S; Freifelder, R

    1992-04-01

    Current trends in positron emission tomography (PET) instrumentation are examined, with an emphasis on providing information suitable to the prospective PET user. Basic principles underlying PET are explained and information on performance measurements, techniques, and quantitation are given in order to allow the user to compare and contrast different types of PET scanners. These scanner designs are described. Specific examples are given and the combination of PET with other modalities is discussed.

  18. Large Antenna Control Methods: Current Status and Future Trends

    Science.gov (United States)

    Rodriguez, G.; Lin, Y. H.; Milman, M. H.

    1985-01-01

    Current methods for control of large antennas, as well as future trends required for improved performance are addressed. Some of the target missions in which these methods would be used are: the Land Mobile Satellite System (LMSS) for communications; the Satellite Surveillance (SSS) for aircraft traffic control; the orbiting Very Long Baseline Interferometer (VLBI), or QUASAT, for radio astronomy; and the Large Deployable Reflector (LDR) for IR and submillimeter astronomy.

  19. Current Technology Trends for School Library Media Specialists

    Directory of Open Access Journals (Sweden)

    Leticia Ekhaml

    2003-03-01

    Full Text Available An overview of some of the current technology trends used in classroom instruction and school library media centers in provided in this article such as the use of handheld electronic organizers, CD recorders, digital video cameras, and interactive whiteboards. The article offers some suggestions or ideas on how to acquire new technologies to school library media centers that are low in budgetary funds.

  20. Current Trends in Graduate Education in Astronomy in Canada

    Science.gov (United States)

    Percy, J. R.; Douglas, K. A.

    2002-12-01

    We begin by describing the infrastructure for graduate education and research in astronomy in Canada. We then describe recent and current trends and issues, including facilities, funding, curriculum, and job prospects. This information has been collected through two channels: through graduate coordinators in astronomy departments and groups in Canadian universities, and through the Graduate Student Committee of the Canadian Astronomical Society (CAS). We emphasize the benefits of having a graduate student chapter in societies such as the CAS and the AAS.

  1. Current Application of Search Engines and Their Developing Trend

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li; SHAO Shi-huang; WU Xiao-qiong; ZENG Xian-hui; FAN Xiao-wen

    2002-01-01

    The basic types of current search engines which can help users to perfume laborious information-gathering tasks on Internet is proposed. Basically, the search engines can be classified into index engine, directory engine and agent engine on WWW information service. The key technologies of web mine, automatic classifying of documents and ordering regulation of feedback information are discussed. Finally, the developing trend of search engines is pointed out by analyzing their practical application on World Wide Web.

  2. High-quality lossy compression: current and future trends

    Science.gov (United States)

    McLaughlin, Steven W.

    1995-01-01

    This paper is concerned with current and future trends in the lossy compression of real sources such as imagery, video, speech and music. We put all lossy compression schemes into common framework where each can be characterized in terms of three well-defined advantages: cell shape, region shape and memory advantages. We concentrate on image compression and discuss how new entropy constrained trellis-based compressors achieve cell- shape, region-shape and memory gain resulting in high fidelity and high compression.

  3. Persistent current and transmission probability in the Aharonov-Bohm ring with an embedded quantum dot

    Energy Technology Data Exchange (ETDEWEB)

    Wu Suzhi; Li Ning [National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093 (China); Jin Guojun [National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093 (China)], E-mail: gjin@nju.edu.cn; Ma Yuqiang [National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093 (China)

    2008-03-24

    Persistent current and transmission probability in the Aharonov-Bohm (AB) ring with an embedded quantum dot (QD) are studied using the technique of the scattering matrix. For the first time, we find that the persistent current can arise in the absence of magnetic flux in the ring with an embedded QD. The persistent current and the transmission probability are sensitive to the lead-ring coupling and the short-range potential barrier. It is shown that increasing the lead-ring coupling or the short-range potential barrier causes the suppression of the persistent current and the increasing resonance width of the transmission probability. The effect of the potential barrier on the number of the transmission peaks is also investigated. The dependence of the persistent current and the transmission probability on the magnetic flux exhibits a periodic property with period of the flux quantum.

  4. Persistent Spin and Charge Currents in Open Conducting Ring Subjected to Rashba Spin-Orbit Coupling

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xi-Sua; XIONG Shi-Jie

    2008-01-01

    We investigate persistent charge and spin currents of a one-dimensional ring with Rashba spin-orbit coupling and connected asymmetrically to two external leads spanned with angle (φ)0.Because of the asymmetry of the structure and the spin-reflection,the persistent charge and spin currents can be induced.The magnification of persistent currents can be obtained when tuning the energy of incident electron to the sharp zero and sharp resonance of transmission depending on the Aharonov-Casher (AC) phase due to the spin-orbit coupling and the angle spanned by two leads (φ)0.The general dependence of the charge and spin persistent currents on these parameters is obtained.This suggests a possible method of controlling the magnitude and direction of persistent currents by tuning the AC phase and (φ)0,without the electromagnetic flux though the ring.

  5. Localized persistent spin currents in defect-free quasiperiodic rings with Aharonov-Casher effect

    Science.gov (United States)

    Qiu, R. Z.; Chen, C. H.; Cheng, Y. H.; Hsueh, W. J.

    2015-06-01

    We propose strongly localized persistent spin current in one-dimensional defect-free quasiperiodic Thue-Morse rings with Aharonov-Casher effect. The results show that the characteristics of these localized persistent currents depend not only on the radius filling factor, but also on the strength of the spin-orbit interaction. The maximum persistent spin currents in systems always appear in the ring near the middle position of the system array whether or not the Thue-Morse rings array is symmetrical. The magnitude of the persistent currents is proportional to the sharpness of the resonance peak, which is dependent on the bandwidth of the allowed band in the band structure. The maximum persistent spin currents also increase exponentially as the generation order of the system increases.

  6. Current trends in molecular diagnostics of chronic myeloid leukemia.

    Science.gov (United States)

    Vinhas, Raquel; Cordeiro, Milton; Pedrosa, Pedro; Fernandes, Alexandra R; Baptista, Pedro V

    2017-08-01

    Nearly 1.5 million people worldwide suffer from chronic myeloid leukemia (CML), characterized by the genetic translocation t(9;22)(q34;q11.2), involving the fusion of the Abelson oncogene (ABL1) with the breakpoint cluster region (BCR) gene. Early onset diagnosis coupled to current therapeutics allow for a treatment success rate of 90, which has focused research on the development of novel diagnostics approaches. In this review, we present a critical perspective on current strategies for CML diagnostics, comparing to gold standard methodologies and with an eye on the future trends on nanotheranostics.

  7. Trends in the exchange current for hydrogen evolution

    DEFF Research Database (Denmark)

    Nørskov, Jens Kehlet; Bligaard, Thomas; Logadottir, Ashildur;

    2005-01-01

    A density functional theory database of hydrogen chemisorption energies on close packed surfaces of a number of transition and noble metals is presented. The bond energies are used to understand the trends in the exchange current for hydrogen evolution. A volcano curve is obtained when measured...... exchange currents are plotted as a function of the calculated hydrogen adsorption energies and a simple kinetic model is developed to understand the origin of the volcano. The volcano curve is also consistent with Pt being the most efficient electrocatalyst for hydrogen evolution. (c) 2005...

  8. European Regional Populations: Current Trends, Future Pathways, and Policy Options.

    Science.gov (United States)

    Rees, Philip; van der Gaag, Nicole; de Beer, Joop; Heins, Frank

    2012-11-01

    Europe is currently experiencing an ageing population and slowing population growth of both the total and working-age populations. These trends are likely to continue. Even though population ageing will affect all European regions, different regions will be affected in different ways. Even under favorable conditions, 35-40 % of all NUTS2 regions will face a labor force decline. If economic conditions are poor, some regions may continue to grow, but 55-70 % of the regions will see a labor force decline by 10 % or more. In most regions of Eastern Europe, the labor force may decrease by more than 30 %. To keep regions prosperous (maintaining competitiveness) and to avoid worse inequality (maintaining cohesion), policy-makers must find ways to cope with these challenges through new fiscal and social policies, though policies directly affecting demographic and migratory trends may also be needed.

  9. Biosolids disposal: An international overview of current and future trends

    Energy Technology Data Exchange (ETDEWEB)

    Evans, B

    1993-03-01

    The current trend in wastewater treatment is toward optimization, reuse, and beneficial use of biosolids. Key considerations in the selection of a sludge management process include long-term viability, sludge quality, markets for sludge-derived products, storage requirements, and whether the project will be able to obtain approvals. Beneficial uses of biosolids include agriculture and landscaping, construction materials, and energy; emerging technologies for utilizing sludges include biobrick production, animal feed production, vermiculture, pyrolysis of sludge to produce oil, manufacturing cement using sludge, and sludge liming for use in agriculture. An important use of sludge in Canada will be the use of solids as fertilizer in cleared-out areas of forest. A review is presented of practices in sludge disposal and utilization in Canada, the USA, Europe, and Japan. Some future trends are also noted. 4 tabs.

  10. Persistent currents in metallic rings containing a quantum dot

    Energy Technology Data Exchange (ETDEWEB)

    Machura, Lukasz [Institute of Physics, University of Silesia, Katowice (Poland); Silesian Center for Education and Interdisciplinary Research, University of Silesia, 41-500 Chorzów (Poland); Łuczka, Jerzy, E-mail: jerzy.luczka@us.edu.pl [Institute of Physics, University of Silesia, Katowice (Poland); Silesian Center for Education and Interdisciplinary Research, University of Silesia, 41-500 Chorzów (Poland)

    2015-08-28

    Currents in metallic rings with a quantum dot are studied in the framework of a Langevin equation for a magnetic flux passing through the ring. Two scenarios are considered: one in which thermal fluctuations of the dissipative part of the current are modeled by classical Johnson–Nyquist noise and one in which quantum character of thermal fluctuations is taken into account in terms of a quantum Smoluchowski equation. The impact of the amplitude and phase of the transmission coefficient of the electron through a quantum dot on current characteristics is analyzed. In tailored parameter regimes, both scenarios can exhibit the transition from para- to diamagnetic response of the current versus external magnetic flux. The type of response is more robust to changes of the amplitude of the transmission coefficient and more sensitive to changes of the phase around some values. - Highlights: • Langevin dynamics of the magnetic flux for classical and quantum Smoluchowski regimes. • Current-flux characteristics vs the amplitude and phase of the transmission coefficient. • Crucial role of the phase of the transmission coefficient. • Contribution to the development of effective control of current in mesoscopic rings.

  11. Trends in sociodemographic and health-related indicators in Bangladesh, 1993-2007: will inequities persist?

    Science.gov (United States)

    Khan, Md Mobarak Hossain; Krämer, Alexander; Khandoker, Aklimunnessa; Prüfer-Krämer, Luise; Islam, Anwar

    2011-08-01

    To assess levels, trends and gaps between the poorest and the richest in selected health and human development indicators in Bangladesh. Data for selected indicators associated with sociodemographic characteristics among ever-married women, contraception use, child vaccination, antenatal care practices and health conditions were extracted from the Bangladesh Demographic and Health Surveys conducted in 1993-94, 1996-1997, 1999-2000, 2004 and 2007. Results for the whole sample and for the poorest and the richest wealth quintiles are presented. Positive trends were noted in urbanization, availability of electricity, age at first marriage, use of modern contraception, access to skilled antenatal care, child vaccination, knowledge of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome and overweight and obesity. In contrast, negative trends were seen in factors such as literacy, infant and child mortality, fertility rate, home delivery and malnutrition and underweight. However, changes in these indicators differed between the poorest and richest quintiles. For instance, only the richest quintile experienced rapid urbanization, whereas illiteracy declined more among the poorest. Noteworthy gaps were found in almost all factors. Rich-poor gaps in urbanization, age at marriage, fertility, condom use, home delivery and overweight increased; in contrast, gaps in education, water and sanitation, use of contraception (except condoms) and child vaccination declined. Persistent inequities in Bangladesh endanger equitable and sustainable human development in the country. Pro-poor development strategies based on the principles of equity and quality should be implemented to narrow existing gaps and further promote holistic and equitable human development.

  12. The persistent current in an Aharonov-Bohm ring with a side-coupled quantum dot

    Institute of Scientific and Technical Information of China (English)

    Zhou Bo; Wu Shao-Quan; Sun Wei-Li; Zhou Xiao-Lin

    2004-01-01

    We have investigated the persistent current in a mesoscopic ring with a side-coupled quantum dot. The problems are probed by using the one-impurity Anderson Hamiltonian and are treated with the slave boson mean field theory. It is shown that the persistent current in this system has the spin fluctuations, and the charge transfers between the two subsystems are suppressed in the limit of △/TKo < 1. The minimum value of the persistent current for ζK/L = 5 of the odd parity system provides an opportunity to detect the Kondo screening cloud.

  13. Food and Health Some Current Issues and Future Trends

    OpenAIRE

    Gormley, T. R. (Thomas Ronan)

    1991-01-01

    This paper deals with some of the many current issues and future trends in the area of food, diet and health in Europe. A complete coverage would be impossible in a short article in view of the extent and complexity of the food system and its major interaction with health. It is also important to stress at the outset that food/diet is only one component of health and other factors such as environment, overall lifestyle and genetics also play a major role. The genetic dimension is of particula...

  14. Current trends in the development of laser glasses

    Energy Technology Data Exchange (ETDEWEB)

    Lunter, S.G.; Mit' kin, V.M.; Tolstoi, M.N.; Fedorov, IU.K.

    1988-02-01

    The principal requirements for glasses suitable for use in solid state lasers are briefly discussed, and some current trends in the development of thermally stable laser-grade phosphate glasses based on I-III elements are reviewed. In particular, attention is given to the optimization of glass composition with respect to structural strength and low brittleness; development of new methods for machining and protecting the side surfaces of active elements; development of new glasses with low concentration quenching, such as a lithium-neodymium-lanthanum-phosphate glass; new neodymium glasses with high chemical stability and low crystallizability; and methods for the dehydration of erbium phosphate glasses. 24 references.

  15. Mobile Ad Hoc Networks Current Status and Future Trends

    CERN Document Server

    Loo, Jonathan

    2011-01-01

    Guiding readers through the basics of these rapidly emerging networks to more advanced concepts and future expectations, Mobile Ad hoc Networks: Current Status and Future Trends identifies and examines the most pressing research issues in Mobile Ad hoc Networks (MANETs). Containing the contributions of leading researchers, industry professionals, and academics, this forward-looking reference provides an authoritative perspective of the state of the art in MANETs. The book includes surveys of recent publications that investigate key areas of interest such as limited resources and the mobility o

  16. Neuroimaging in refractory epilepsy. Current practice and evolving trends

    Energy Technology Data Exchange (ETDEWEB)

    Ramli, N. [Department of Biomedical Imaging, University Malaya Research Imaging Centre (Malaysia); Rahmat, K., E-mail: katt_xr2000@yahoo.com [Department of Biomedical Imaging, University Malaya Research Imaging Centre (Malaysia); Lim, K.S.; Tan, C.T. [Neurology Unit, Department of Medicine, University Malaya, Kuala Lumpur (Malaysia)

    2015-09-15

    Highlights: • Neuroimaging is imperative in diagnostic work up and therapeutic assessment of refractory epilepsy. • Identification of epileptogenic zone on EEG, MRI and functional imaging improves the success of surgery. • High performance MRI greatly enhanced metabolic information and elucidate brain functions. • Optimisation of epilepsy protocols in structural and functional MRI are presented in this article. - Abstract: Identification of the epileptogenic zone is of paramount importance in refractory epilepsy as the success of surgical treatment depends on complete resection of the epileptogenic zone. Imaging plays an important role in the locating and defining anatomic epileptogenic abnormalities in patients with medically refractory epilepsy. The aim of this article is to present an overview of the current MRI sequences used in epilepsy imaging with special emphasis of lesion seen in our practices. Optimisation of epilepsy imaging protocols are addressed and current trends in functional MRI sequences including MR spectroscopy, diffusion tensor imaging and fusion MR with PET and SPECT are discussed.

  17. Breakdown of accommodation in nerve: a possible role for persistent sodium current

    Directory of Open Access Journals (Sweden)

    Andersen Ole K

    2005-04-01

    Full Text Available Abstract Background Accommodation and breakdown of accommodation are important elements of information processing in nerve fibers, as they determine how nerve fibers react to natural slowly changing stimuli or electrical stimulation. The aim of the present study was to elucidate the biophysical mechanism of breakdown of accommodation, which at present is unknown. Results A model of a space-clamped motor nerve fiber was developed. It was found that this new model could reproduce breakdown of accommodation when it included a low-threshold, rapidly activating, persistent sodium current. However, the phenomenon was not reproduced when the persistent sodium current did not have fast activation kinetics or a low activation threshold. Conclusion The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions.

  18. A renormalization group study of persistent current in a quasiperiodic ring

    Energy Technology Data Exchange (ETDEWEB)

    Dutta, Paramita [Theoretical Condensed Matter Physics Division, Saha Institute of Nuclear Physics, Sector-I, Block-AF, Bidhannagar, Kolkata-700 064 (India); Maiti, Santanu K., E-mail: santanu.maiti@isical.ac.in [Physics and Applied Mathematics Unit, Indian Statistical Institute, 203 Barrackpore Trunk Road, Kolkata-700 108 (India); Karmakar, S.N. [Theoretical Condensed Matter Physics Division, Saha Institute of Nuclear Physics, Sector-I, Block-AF, Bidhannagar, Kolkata-700 064 (India)

    2014-04-01

    We propose a real-space renormalization group approach for evaluating persistent current in a multi-channel quasiperiodic Fibonacci tight-binding ring based on a Green's function formalism. Unlike the traditional methods, the present scheme provides a powerful tool for the theoretical description of persistent current with a very high degree of accuracy in large periodic and quasiperiodic rings, even in the micron scale range, which emphasizes the merit of this work.

  19. Persistent spin currents in a triple-terminal quantum ring with three arms*

    Institute of Scientific and Technical Information of China (English)

    Du Jian; Wang Suxin; Pan Jianghong; Duan Xiuzhi

    2011-01-01

    A new model of a triple-terminal quantum ring with three arms is proposed. We develop an equivalent method for reducing the triple-terminal quantum ring to the double-terminal quantum ring and calculate the persistent spin currents in this model. The results indicate that the persistent spin currents show behavior of nonperiodic and unequal amplitude oscillation with increasing semiconductor ring size when the total magnetic flux is zero.However, when the total magnetic flux is non-zero, the persistent spin currents make periodic equal amplitude oscillations with increasing AB magnetic flux intensity. At the same time, the two kinds of spin state persistent spin currents have the same frequency and amplitude but the inverse phase. In addition, the Rashba spin-orbit interaction affects the phase and the phase difference of the persistent spin currents. The average persistent spin currents relate to the arm length and the terminal position as well as the distribution of the magnetic flux in each arm. Furthermore,our results indicate that the AB magnetic flux has different influences on the two kinds of spin state electrons.

  20. Persistent sodium current in subicular neurons isolated from patients with temporal lobe epilepsy.

    Science.gov (United States)

    Vreugdenhil, Martin; Hoogland, Govert; van Veelen, Cornelis W M; Wadman, Wytse J

    2004-05-01

    The persistent sodium current is a common target of anti-epileptic drugs and contributes to burst firing. Intrinsically burst firing subicular neurons are involved in the generation and spread of epileptic activity. We measured whole-cell sodium currents in pyramidal neurons isolated from the subiculum resected in drug-resistant epileptic patients and in rats. In half of the cells from both patients and rats, the sodium current inactivated within 500 ms at -30 mV. Others displayed a tetrodotoxin-sensitive slowly or non-inactivating sodium current of up to 53% of the total sodium current amplitude. Compared with the transient sodium current in the same cells, this persistent sodium current activated with normal kinetics but its voltage-dependent activation occurred 7 mV more hyperpolarized. Depolarizing voltage steps that lasted 10 s completely inactivated the persistent sodium current. Its voltage dependence did not differ from that of the transient sodium current but its slope was less steep. The voltage dependence and kinetics of the persistent sodium current in cells from patients were not different from that in subicular cells from rats. The current density and the relative amplitude contribution were 3-4 times greater in neurons from drug-resistant epilepsy patients. The abundant presence of persistent sodium current in half of the subicular neurons could lead to a larger number of neurons with intrinsic burst firing. The extraordinarily large amplitude of the persistent sodium current in this subset of subicular neurons might explain why these patients are susceptible to seizures and hard to treat pharmacologically.

  1. Trends in sociodemographic and health-related indicators in Bangladesh, 1993–2007: will inequities persist?

    Science.gov (United States)

    Krämer, Alexander; Khandoker, Aklimunnessa; Prüfer-Krämer, Luise; Islam, Anwar

    2011-01-01

    Abstract Objective To assess levels, trends and gaps between the poorest and the richest in selected health and human development indicators in Bangladesh. Methods Data for selected indicators associated with sociodemographic characteristics among ever-married women, contraception use, child vaccination, antenatal care practices and health conditions were extracted from the Bangladesh Demographic and Health Surveys conducted in 1993–94, 1996–1997, 1999–2000, 2004 and 2007. Results for the whole sample and for the poorest and the richest wealth quintiles are presented. Findings Positive trends were noted in urbanization, availability of electricity, age at first marriage, use of modern contraception, access to skilled antenatal care, child vaccination, knowledge of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome and overweight and obesity. In contrast, negative trends were seen in factors such as literacy, infant and child mortality, fertility rate, home delivery and malnutrition and underweight. However, changes in these indicators differed between the poorest and richest quintiles. For instance, only the richest quintile experienced rapid urbanization, whereas illiteracy declined more among the poorest. Noteworthy gaps were found in almost all factors. Rich–poor gaps in urbanization, age at marriage, fertility, condom use, home delivery and overweight increased; in contrast, gaps in education, water and sanitation, use of contraception (except condoms) and child vaccination declined. Conclusion Persistent inequities in Bangladesh endanger equitable and sustainable human development in the country. Pro-poor development strategies based on the principles of equity and quality should be implemented to narrow existing gaps and further promote holistic and equitable human development. PMID:21836757

  2. Persistence

    Science.gov (United States)

    Moore, John W.

    1998-11-01

    Eudora Welty, the famous writer, was once asked what should be done by society or government to encourage young writers. Her response, which surprised the questioner, and me when I heard it, was "Nothing". Welty contended that a person who was really a writer would be persistent enough to overcome whatever obstacles were in the way, needing no interference or support from others.

  3. Current trends in gamma radiation detection for radiological emergency response

    Science.gov (United States)

    Mukhopadhyay, Sanjoy; Guss, Paul; Maurer, Richard

    2011-09-01

    Passive and active detection of gamma rays from shielded radioactive materials, including special nuclear materials, is an important task for any radiological emergency response organization. This article reports on the current trends and status of gamma radiation detection objectives and measurement techniques as applied to nonproliferation and radiological emergencies. In recent years, since the establishment of the Domestic Nuclear Detection Office by the Department of Homeland Security, a tremendous amount of progress has been made in detection materials (scintillators, semiconductors), imaging techniques (Compton imaging, use of active masking and hybrid imaging), data acquisition systems with digital signal processing, field programmable gate arrays and embedded isotopic analysis software (viz. gamma detector response and analysis software [GADRAS]1), fast template matching, and data fusion (merging radiological data with geo-referenced maps, digital imagery to provide better situational awareness). In this stride to progress, a significant amount of inter-disciplinary research and development has taken place-techniques and spin-offs from medical science (such as x-ray radiography and tomography), materials engineering (systematic planned studies on scintillators to optimize several qualities of a good scintillator, nanoparticle applications, quantum dots, and photonic crystals, just to name a few). No trend analysis of radiation detection systems would be complete without mentioning the unprecedented strategic position taken by the National Nuclear Security Administration (NNSA) to deter, detect, and interdict illicit trafficking in nuclear and other radioactive materials across international borders and through the global maritime transportation-the so-called second line of defense.

  4. Trends in prescribing and persistence with antihypertensive therapy: results of the study PAPEETE (Population-based Analysis of Persistence and Economics of treatment with telmisartan study

    Directory of Open Access Journals (Sweden)

    Francesco Vittorio Costa

    2009-12-01

    Full Text Available This paper summarizes the results of the PAPEETE study (Population-based Analysis of PErsistence with treatment and Economics of TElmisartan that assessed trends in prescriptions, determinants and timing of treatment discontinuation and/or changes in antihypertensive drug therapy in a cohort of hypertensive patients living in Pavia. In the study were included all new users 18 years old or over receiving a first prescription for diuretics, beta-blockers, calcium channel-blockers, ACE inhibitors (ACEi or angiotensin receptor blockers (ARBs between 1 January 2003 and 31 December 2006. The follow-up period for each patient was 12 months starting from enrolment date. Based in the presence of continuous therapy, patients were defined as persistent and non-persistent users. A total of 61,493 patients was included in the study of whom 11.2% were persistent. Persistence with the treatment seems to be associated with patient-related factors and with the class of anti-hypertensive drug initially prescribed with the lowest persistence to antihypertensive treatment with diuretics (3.0% and the highest with ARBs (18.8%.

  5. Current Trends in Local Policing Provision in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Oldřich Krulík

    2014-12-01

    Full Text Available The paper examines the current trends of national police forces as they increasingly often pull back from their positions, and the consequences which many municipal councils in the Czech Republic are now facing. In the last couple of years, some municipalities chose relatively unconventional ways to deal with increased levels of crime and other forms of antisocial behaviour on their territories. This created space – for example – for signing public agreements with other municipalities, hiring private security companies to perform the role of municipal police or various forms of sponsoring the Police of the Czech Republic.

  6. Drug therapy of attention deficit hyperactivity disorder: Current trends

    Directory of Open Access Journals (Sweden)

    Avinash De Sousa

    2012-01-01

    Full Text Available Attention deficit hyperactivity disorder is a developmental disorder with an age onset prior to 7 years. Children with ADHD have significantly lower ability to focus and sustain attention and also score higher on impulsivity and hyperactivity. Stimulants, such as methylphenidate, have remained the mainstay of ADHD treatment for decades with evidence supporting their use. However, recent years have seen emergence of newer drugs and drug delivery systems, like osmotic release oral systems and transdermal patches, to mention a few. The use of nonstimulant drugs like atomoxetine and various other drugs, such as a-agonists, and a few antidepressants, being used in an off-label manner, have added to the pharmacotherapy of ADHD. This review discusses current trends in drug therapy of ADHD and highlights the promise pharmacogenomics may hold in the future.

  7. Current and future trends in imaging informatics for oncology.

    Science.gov (United States)

    Levy, Mia A; Rubin, Daniel L

    2011-01-01

    Clinical imaging plays an essential role in cancer care and research for diagnosis, prognosis, and treatment response assessment. Major advances in imaging informatics to support medical imaging have been made during the last several decades. More recent informatics advances focus on the special needs of oncologic imaging, yet gaps still remain. We review the current state, limitations, and future trends in imaging informatics for oncology care including clinical and clinical research systems. We review information systems to support cancer clinical workflows including oncologist ordering of radiology studies, radiologist review and reporting of image findings, and oncologist review and integration of imaging information for clinical decision making. We discuss informatics approaches to oncologic imaging including, but not limited to, controlled terminologies, image annotation, and image-processing algorithms. With the ongoing development of novel imaging modalities and imaging biomarkers, we expect these systems will continue to evolve and mature.

  8. Current trends in separation of plasmid DNA vaccines: a review.

    Science.gov (United States)

    Ghanem, Ashraf; Healey, Robert; Adly, Frady G

    2013-01-14

    Plasmid DNA (pDNA)-based vaccines offer more rapid avenues for development and production if compared to those of conventional virus-based vaccines. They do not rely on time- or labour-intensive cell culture processes and allow greater flexibility in shipping and storage. Stimulating antibodies and cell-mediated components of the immune system are considered as some of the major advantages associated with the use of pDNA vaccines. This review summarizes the current trends in the purification of pDNA vaccines for practical and analytical applications. Special attention is paid to chromatographic techniques aimed at reducing the steps of final purification, post primary isolation and intermediate recovery, in order to reduce the number of steps necessary to reach a purified end product from the crude plasmid.

  9. Current Trends in High-Level Synthesis of Asynchronous Circuits

    DEFF Research Database (Denmark)

    Sparsø, Jens

    2009-01-01

    This paper is a survey paper presenting what the author sees as two major and promising trends in the current research in CAD-tools and design-methods for asynchronous circuits. One branch of research builds on top of existing asynchronous CAD-tools that perform syntax directed translation, e.......g. the Haste/TiDE tool from Handshake Solutions or the Balsa tool from the University of Manchester. The aims are to add highlevel synthesis capabilities to these tools and to extend the tools such that a wider range of (higher speed) micro-architectures can be generated. Another branch of research takes...... a conventional synchronous circuit as the starting point, and then adds some form of handshake-based flow-control. One approach keeps the global clock and implements discrete-time asynchronous operation. Another approach substitutes the clocked registers by asynchronous handshake-registers, thus creating truly...

  10. A voltage-dependent persistent sodium current in mammalian hippocampal neurons

    OpenAIRE

    1990-01-01

    Currents generated by depolarizing voltage pulses were recorded in neurons from the pyramidal cell layer of the CA1 region of rat or guinea pig hippocampus with single electrode voltage-clamp or tight- seal whole-cell voltage-clamp techniques. In neurons in situ in slices, and in dissociated neurons, subtraction of currents generated by identical depolarizing voltage pulses before and after exposure to tetrodotoxin revealed a small, persistent current after the transient current. These curren...

  11. Wind turbines: current status, obstacles, trends and technologies

    Science.gov (United States)

    Konstantinidis, E. I.; Botsaris, P. N.

    2016-11-01

    The last decade the installation of wind farms around the world is spreading rapidly and wind energy has become a significant factor for promoting sustainable development. The scope of the present study is to indicate the present status of global wind power expansion as well as the current state of the art in the field of wind turbine technology. The RAM (reliability/availability/maintenance) section is also examined and the Levelized Cost of Energy for onshore/ offshore electricity production is presented. Negative consequences that go with the rapid expansion of wind power like accidents, environmental effects, etc. are highlighted. Especially visual impact to the landscape and noise pollution are some factors that provoke social reactions. Moreover, the complicated and long permitted process of a wind power plant, the high capital cost of the investment and the grid instability due to the intermittent nature of wind, are also significant obstacles in the development of the wind energy production. The current trends in the field of research and development of onshore and offshore wind power production are analyzed. Finally the present study is trying to achieve an estimation of where the wind industry targets for the years to come.

  12. LIFELONG LEARNING THROUGH SECOND LIFE: CURRENT TRENDS, POTENTIALS AND LIMITATIONS

    Directory of Open Access Journals (Sweden)

    Nil GOKSEL-CANBEK

    2011-08-01

    Full Text Available Lifelong Learning (LLL has been a remarkable response to people-centered educational demand of 21st century. In order to provide effective formal, non-formal, and informal learning, immersive educational activities undertaken throughout life should be aimed to create a learning society in which people can experience individual and collective learning with no constrains of time or location. The concept of lifelong learning within the context of distance immersive education encompasses diverse 3D activities. The three dimensional, Web-based structured activities supported by distance learning technologies can be viewed as interactive tools which foster LLL. In this perspective, Second Life (SL can be regarded as one of the learning simulation milieus that allow learners to participate in various educational LLL activities in individual or group forms. The following paper examines how SL, taking advantage of its simulative nature and the possibility for creative interaction among participants, which are also common in games, allows the learners to participate in immersive constructivist learning activities. The article will also touch on the current uses of SL as a tool for LLL, as well as its potentials for further development according to the current trends in adult education. Further, the authors will discuss its limitations and will make suggestions towards a more complete pedagogical use.

  13. Cold and hot extremozymes: industrial relevance and current trends

    Directory of Open Access Journals (Sweden)

    Felipe eSarmiento

    2015-10-01

    Full Text Available The development of enzymes for industrial applications relies heavily on the use of microorganisms. The intrinsic properties of microbial enzymes e.g. consistency, reproducibility and high yields along with many others, has pushed their introduction into a wide range of products and industrial processes. Extremophilic microorganisms represent an underutilized and innovative source of novel enzymes. These microorganisms have developed unique mechanisms and molecular means to cope with extreme temperatures, acidic and basic pH, high salinity, high radiation, low water activity, and high metal concentrations among other environmental conditions.Extremophile derived enzymes, or extremozymes, are able to catalyze chemical reactions under harsh conditions, like those found in industrial processes, which were previously not thought to be conducive for enzymatic activity. Due to their optimal activity and stability under extreme conditions, extremozymes offer new catalytic alternatives for current industrial applications. These extremozymes also represent the cornerstone for the development of environmentally-friendly, efficient and sustainable industrial technologies. Many advances in industrial biocatalysis have been achieved in recent years, however, the potential of biocatalysis through the use of extremozymes is far from being fully realized. In this article, the adaptations and significance of psychrophilic, thermophilic and hyperthermophilic enzymes, and their applications in selected industrial markets will be reviewed. Also the current challenges in the development and mass-production of extremozymes as well as future prospects and trends for their biotechnological application will be discussed.

  14. PERSISTENT CURRENT EFFECT IN 15-16 T NB3SN ACCELERATOR DIPOLES AND ITS CORRECTION

    Energy Technology Data Exchange (ETDEWEB)

    Kashikhin, V. V. [Fermilab; Zlobin, A. V. [Fermilab

    2016-11-08

    Nb3Sn magnets with operating fields of 15-16 T are considered for the LHC Energy Doubler and a future Very High Energy pp Collider. Due to large coil volume, high critical current density and large superconducting (SC) filament size the persistent current effect is very large in Nb3Sn dipoles al low fields. This paper presents the results of analysis of the persistent current effect in the 15 T Nb3Sn dipole demonstrator being developed at FNAL, and describes different possibilities of its correction including passive SC wires, iron shims and coil geometry.

  15. Current Trends, Evaluation, and Management of Pediatric Nephrolithiasis.

    Science.gov (United States)

    Hernandez, Joel D; Ellison, Jonathan S; Lendvay, Thomas S

    2015-10-01

    The incidence of pediatric nephrolithiasis has been steadily increasing for the past several decades, with a concomitant concerning increase in health care costs and burden to children with this disease. Recent population-based studies have also demonstrated a change in the current trends of pediatric nephrolithiasis that is characterized by a significant increase in the number of girls now being affected. While changes in diet and lifestyle, obesity prevalence, and even imaging practices have been proposed to contribute to the recent increase in pediatric nephrolithiasis, a definite underlying cause remains elusive. This situation is complicated by the fact that, unlike in adults, the trends occurring in pediatric nephrolithiasis have not been studied rigorously, which contributes to the paucity of data in children. The level of concern with the increasing incidence is raised by factors unique to pediatric nephrolithiasis that could expose an affected child to more complications. Factors such as variable clinical presentation, high recurrence of kidney stones associated with abnormalities of metabolism and the urinary tract, and the possible presence of rare genetic kidney stone diseases would require physicians to comprehensively evaluate patients presenting with kidney stones. The goal of evaluation is to identify modifiable risk factors and abnormalities for which targeted therapy can be prescribed. The goals of medical and surgical treatments are to eliminate the burden of kidney stones and prevent recurrence while simultaneously minimizing complications from interventions. Patients at high risk may benefit from a specialized kidney stone clinic staffed by a pediatric nephrologist, urologist, dietitian, and clinical nurse. Such a multidisciplinary clinic can help provide the medical and surgical support needed for patients at high risk and offer key opportunities to learn more about pediatric nephrolithiasis, thereby fueling the much-needed research in this

  16. Current trends in colchicine treatment in familial Mediterranean fever.

    Science.gov (United States)

    La Regina, Micaela; Ben-Chetrit, Eldad; Gasparyan, Armen Yuri; Livneh, Avi; Ozdogan, Huri; Manna, Raffaele

    2013-01-01

    Since the publication of the first reports on the efficiency of colchicine in familial Mediterranean fever (FMF), very few randomised studies have investigated issues related to its long-term use. Thus, different approaches taken by physicians involved in FMF care, are exclusively empiric, emulative, and based on case-reports or case-series. Problems such as colchicine intolerance and colchicine resistance have not been solved yet. This paper aims to evaluate trends in colchicine therapy among physicians taking care of FMF patients around the world. We conducted a survey by sending questionnaires to FMF research and treatment centres in Europe and Asia. Many issues (such as dosages, schedules, side effects, interactions, efficacy and toxicity monitoring, definition of colchicine intolerance, colchicine resistance and responsiveness, etc) have been investigated. When more than 70% of physicians responded giving similar answers to an item, the response was considered as a 'trend'. A comparison between answers of physicians from FMF-prevalent and non-prevalent countries was also made. Thirty-five physicians from 11 countries filled the questionnaires, taking care of a total of more than 15000 FMF patients (pts). Different approaches were evident among the various physicians. Statistically significant different approaches between physicians from FMF-prevalent countries with respect to those from non-prevalent countries were found in items like colchicine during pregnancy, severity score and blood tests for disease monitoring. No consensus was found regarding the definition of colchicine resistance. The current study demonstrated significant variations in the strategy of colchicine therapy for FMF around the world and re-emphasised the need for standardised definitions of colchicine resistance and colchicine intolerance.

  17. Current Trends in Adolescent Substance Use in Jamaica

    Directory of Open Access Journals (Sweden)

    U Atkinson

    2015-03-01

    Full Text Available Objective: National secondary school-based drug surveys facilitate the identification and understanding of patterns of substance use among adolescents, associated risk and protective factors which exist and inform prevention and treatment interventions and policies which are appropriate for resource constrained settings. This paper analyses current trends as well as reviews trends from the last National School Survey conducted by the National Council on Drug Abuse in 2006. Method: The study utilized a survey design that included a representative sample of secondary school students. Data were collected from 3365 students from 38 schools across the island. The study made specific reference to the prevalence of alcohol, tobacco cigarette, marijuana and inhalant use among secondary school students. Results: The most widely used substances among the sample were alcohol, tobacco cigarettes, marijuana and solvents/inhalants. A large number of students (64% reported a lifetime prevalence of alcohol use. Alcohol use was also the highest for one-year (44% and one-month (33.6% use. While lifetime use of tobacco cigarette was higher than marijuana, one-year and one-month use of marijuana was higher than that of tobacco cigarette. There has been a slight increase in the age of initiation for alcohol, tobacco cigarette and marijuana use. There has also been a significant decrease (approximately 50% in lifetime, past year and past month prevalence of inhalant use since the 2006 secondary school survey. Conclusions: Alcohol continues to be the substance most widely used by Jamaican adolescents, followed by tobacco, marijuana and inhalants. Though the average age of first use has slightly increased for all substances, prevalence remains a concern. As such, innovative school-based interventions are required to assist in reducing substance use among Jamaican adolescents.

  18. Current status and future trends of medical physics in Mexico

    Science.gov (United States)

    Azorin Nieto, J.

    2015-01-01

    Medical Physics is an area that applies the principles of physics to medicine, particularly in the prevention, diagnosis and treatment of diseases using ionizing and nonionizing radiation. The main attractive of medical physics is that it has a direct impact on the quality and safety of medical care in humans; this social component with direct implications for the population is of high value for Mexico. This paper describes the concepts of medical physics, trends and the current status of this discipline as a profession, which is directly related to the efforts of clinical research. It is also described what is, in my opinion, the future of medical physics in Mexico, emphasizing the fact that this field requires a substantial boost from universities and hospitals to recruit highly qualified young medical physicists and the support from government agencies such as Secretaria de Salud, Instituto Mexicano del Seguro Social and Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado through clinical research projects that allow the necessary evolution of medical physics into the hospital setting.

  19. Current trends in inflammatory and immunomodulatory mediators in sepsis

    Science.gov (United States)

    Aziz, Monowar; Jacob, Asha; Yang, Weng-Lang; Matsuda, Akihisa; Wang, Ping

    2013-01-01

    Sepsis refers to severe systemic inflammation in response to invading pathogens. An overwhelming immune response, as mediated by the release of various inflammatory mediators, can lead to shock, multiple organ damage, and even death. Cytokines, proteases, lipid mediators, gaseous substances, vasoactive peptides, and cell stress markers play key roles in sepsis pathophysiology. Various adhesion molecules and chemokines sequester and activate neutrophils into the target organs, further augmenting inflammation and tissue damage. Although the anti-inflammatory substances counterbalance proinflammatory mediators, prolonged immune modulation may cause host susceptibility to concurrent infections, thus reflecting enormous challenge toward developing effective clinical therapy against sepsis. To understand the complex interplay between pro- and anti-inflammatory phenomenon in sepsis, there is still an unmet need to study newly characterized mediators. In addition, revealing the current trends of novel mediators will upgrade our understanding on their signal transduction, cross-talk, and synergistic and immunomodulating roles during sepsis. This review highlights the latest discoveries of the mediators in sepsis linking to innate and adaptive immune systems, which may lead to resolution of many unexplored queries. PMID:23136259

  20. Current Trends in Internet Usage and Cyber Crimes against Youth

    Directory of Open Access Journals (Sweden)

    Divya Bansal

    2011-06-01

    Full Text Available Based on a written survey, this paper examines the current trends in internet use and cyber crime against youth for a given set of demographic conditions and presents suggestions for related safety measures and precautions. A written survey of young internet users aged between 10 and 17 years was conducted in the schools of Chandigarh, India. It showed that nearly 84 percent of the youth surveyed have internet connectivity at their homes. Seventy percent of the youth surveyed use the internet for social networking, the majority of whom share photographs, videos and personal information online. Fifteen percent of the youth reported online harassment, and approximately 30 percent reported online interaction with unknown people. According to the youth surveyed, the parents or guardians of more than 90 percent know about their browsing habits. In most cases parents or guardians had talked to their children about internet safety and possible threats. Schools and parents/guardians should ensure that the children are aware of internet dangers, including the dangers of sharing personal information and trusting unknown people online, and regulate their browsing activities.

  1. Hypertension in Latin America: Current perspectives on trends and characteristics.

    Science.gov (United States)

    Ruilope, L M; Chagas, A C P; Brandão, A A; Gómez-Berroterán, R; Alcalá, J J A; Paris, J V; Cerda, J J O

    The region of Latin America, which includes Central America, the Caribbean and South America, is one that is rapidly developing. Signified by socio-economic growth, transition and development over the last few decades, living standards in countries like Brazil and Mexico have improved dramatically, including improvements in education and health care. An important marker of socio-economic change has been the epidemiological shift in disease burden. Cardiovascular disease is now the leading cause of death in Latin America, and the drop in prevalence of infectious diseases has been accompanied by a rise in non-communicable diseases. Hypertension is the major risk factor driving the cardiovascular disease continuum. In this article we aim to discuss the epidemiological and management trends and patterns in hypertension that may be specific or more common to Latin-American populations - what we term 'Latin American characteristics' of hypertension - via a review of the recent literature. Recognizing that there may be a specific profile of hypertension for Latin-American patients may help to improve their treatment, with the ultimate goal to reduce their cardiovascular risk. We focus somewhat on the countries of Brazil, Mexico and Venezuela, the experience of which may reflect other Latin American countries that currently have less published data regarding epidemiology and management practices. Copyright © 2016 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.

  2. Review on the current trends in tongue diagnosis systems

    Directory of Open Access Journals (Sweden)

    Chang Jin Jung

    2012-12-01

    Full Text Available Tongue diagnosis is an essential process to noninvasively assess the condition of a patient's internal organs in traditional medicine. To obtain quantitative and objective diagnostic results, image acquisition and analysis devices called tongue diagnosis systems (TDSs are required. These systems consist of hardware including cameras, light sources, and a ColorChecker, and software for color correction, segmentation of tongue region, and tongue classification. To improve the performance of TDSs, various types TDSs have been developed. Hyperspectral imaging TDSs have been suggested to acquire more information than a two-dimensional (2D image with visible light waves, as it allows collection of data from multiple bands. Three-dimensional (3D imaging TDSs have been suggested to provide 3D geometry. In the near future, mobile devices like the smart phone will offer applications for assessment of health condition using tongue images. Various technologies for the TDS have respective unique advantages and specificities according to the application and diagnostic environment, but this variation may cause inconsistent diagnoses in practical clinical applications. In this manuscript, we reviewed the current trends in TDSs for the standardization of systems. In conclusion, the standardization of TDSs can supply the general public and oriental medical doctors with convenient, prompt, and accurate information with diagnostic results for assessing the health condition.

  3. Type 2 Diabetes Mellitus: A Review of Current Trends

    Directory of Open Access Journals (Sweden)

    Abdulfatai B. Olokoba

    2012-07-01

    Full Text Available Type 2 diabetes mellitus (DM is a chronic metabolic disorder in which prevalence has been increasing steadily all over the world. As a result of this trend, it is fast becoming an epidemic in some countries of the world with the number of people affected expected to double in the next decade due to increase in ageing population, thereby adding to the already existing burden for healthcare providers, especially in poorly developed countries. This review is based on a search of Medline, the Cochrane Database of Systemic Reviews, and citation lists of relevant publications. Subject heading and key words used include type 2 diabetes mellitus, prevalence, current diagnosis, and current treatment. Only articles in English were included. Screening and diagnosis is still based on World Health Organization (WHO and American Diabetes Association (ADA criteria which include both clinical and laboratory parameters. No cure has yet been found for the disease; however, treatment modalities include lifestyle modifications, treatment of obesity, oral hypoglycemic agents, and insulin sensitizers like metformin, a biguanide that reduces insulin resistance, is still the recommended first line medication especially for obese patients. Other effective medications include non-sulfonylurea secretagogues, thiazolidinediones, alpha glucosidase inhibitors, and insulin. Recent research into the pathophysiology of type 2 DM has led to the introduction of new medications like glucagon-like peptide 1 analogoues: dipeptidyl peptidase-IV inhibitors, inhibitors of the sodium-glucose cotransporter 2 and 11ß-hydroxysteroid dehydrogenase 1, insulin-releasing glucokinase activators and pancreatic-G-protein-coupled fatty-acid-receptor agonists, glucagon-receptor antagonists, metabolic inhibitors of hepatic glucose output and quick-release bromocriptine. Inhaled insulin was licensed for use in 2006 but has been withdrawn from the market because of low patronage.

  4. Persistent Directional Current at Equilibrium in Nonreciprocal Many-Body Near Field Electromagnetic Heat Transfer

    Science.gov (United States)

    Zhu, Linxiao; Fan, Shanhui

    2016-09-01

    We consider the consequence of nonreciprocity in near-field heat transfer by studying systems consisting of magneto-optical nanoparticles. We demonstrate that, in thermal equilibrium, a nonreciprocal many-body system in heat transfer can support a persistent directional heat current, without violating the second law of thermodynamics. Such a persistent directional heat current cannot occur in reciprocal systems, and can only arise in many-body systems in heat transfer. The use of nonreciprocity therefore points to a new regime of near-field heat transfer for the control of heat flow in the nanoscale.

  5. Controllable Persistent Atom Current of Bose-Einstein Condensates in an Optical Lattice Ring

    Institute of Scientific and Technical Information of China (English)

    ZHENG Gong-Ping; LIANG Jiu-Qing

    2005-01-01

    In this paper the macroscopic quantum state of Bose-Einstein condensates in optical lattices is studied by solving the periodic Gross-Pitaevskii equation in one-dimensional geometry. It is shown that an exact solution seen to be a travelling wave of excited macroscopic quantum states resultes in a persistent atom current, which can be controlled by adjusting of the barrier height of the optical periodic potential. A critical condition to generate the travelling wave is demonstrated and we moreover propose a practical experiment to realize the persistent atom current in a toroidal atom waveguide.

  6. Current and future trends in marine image annotation software

    Science.gov (United States)

    Gomes-Pereira, Jose Nuno; Auger, Vincent; Beisiegel, Kolja; Benjamin, Robert; Bergmann, Melanie; Bowden, David; Buhl-Mortensen, Pal; De Leo, Fabio C.; Dionísio, Gisela; Durden, Jennifer M.; Edwards, Luke; Friedman, Ariell; Greinert, Jens; Jacobsen-Stout, Nancy; Lerner, Steve; Leslie, Murray; Nattkemper, Tim W.; Sameoto, Jessica A.; Schoening, Timm; Schouten, Ronald; Seager, James; Singh, Hanumant; Soubigou, Olivier; Tojeira, Inês; van den Beld, Inge; Dias, Frederico; Tempera, Fernando; Santos, Ricardo S.

    2016-12-01

    . Integration into available MIAS is currently limited to semi-automated processes of pixel recognition through computer-vision modules that compile expert-based knowledge. Important topics aiding the choice of a specific software are outlined, the ideal software is discussed and future trends are presented.

  7. Some Current Trends in Applied Linguistics: Towards a Generic View

    Science.gov (United States)

    Bygate, Martin

    2004-01-01

    This paper argues that the most significant trend in applied linguistics is the emergence of the field as a generic discipline, involving several subareas, all characterised by the aim of developing theoretical and empirical studies of language as a key element in real world problems. Various subsidiary trends are apparent including numerous…

  8. A voltage-dependent persistent sodium current in mammalian hippocampal neurons.

    Science.gov (United States)

    French, C R; Sah, P; Buckett, K J; Gage, P W

    1990-06-01

    Currents generated by depolarizing voltage pulses were recorded in neurons from the pyramidal cell layer of the CA1 region of rat or guinea pig hippocampus with single electrode voltage-clamp or tight-seal whole-cell voltage-clamp techniques. In neurons in situ in slices, and in dissociated neurons, subtraction of currents generated by identical depolarizing voltage pulses before and after exposure to tetrodotoxin revealed a small, persistent current after the transient current. These currents could also be recorded directly in dissociated neurons in which other ionic currents were effectively suppressed. It was concluded that the persistent current was carried by sodium ions because it was blocked by TTX, decreased in amplitude when extracellular sodium concentration was reduced, and was not blocked by cadmium. The amplitude of the persistent sodium current varied with clamp potential, being detectable at potentials as negative as -70 mV and reaching a maximum at approximately -40 mV. The maximum amplitude at -40 mV in 21 cells in slices was -0.34 +/- 0.05 nA (mean +/- 1 SEM) and -0.21 +/- 0.05 nA in 10 dissociated neurons. Persistent sodium conductance increased sigmoidally with a potential between -70 and -30 mV and could be fitted with the Boltzmann equation, g = gmax/(1 + exp[(V' - V)/k)]). The average gmax was 7.8 +/- 1.1 nS in the 21 neurons in slices and 4.4 +/- 1.6 nS in the 10 dissociated cells that had lost their processes indicating that the channels responsible are probably most densely aggregated on or close to the soma. The half-maximum conductance occurred close to -50 mV, both in neurons in slices and in dissociated neurons, and the slope factor (k) was 5-9 mV. The persistent sodium current was much more resistant to inactivation by depolarization than the transient current and could be recorded at greater than 50% of its normal amplitude when the transient current was completely inactivated. Because the persistent sodium current activates at

  9. Current trends and future directions in flower development research.

    Science.gov (United States)

    Scutt, Charlie P; Vandenbussche, Michiel

    2014-11-01

    Flowers, the reproductive structures of the approximately 400 000 extant species of flowering plants, exist in a tremendous range of forms and sizes, mainly due to developmental differences involving the number, arrangement, size and form of the floral organs of which they consist. However, this tremendous diversity is underpinned by a surprisingly robust basic floral structure in which a central group of carpels forms on an axis of determinate growth, almost invariably surrounded by two successive zones containing stamens and perianth organs, respectively. Over the last 25 years, remarkable progress has been achieved in describing the molecular mechanisms that control almost all aspects of flower development, from the phase change that initiates flowering to the final production of fruits and seeds. However, this work has been performed almost exclusively in a small number of eudicot model species, chief among which is Arabidopsis thaliana. Studies of flower development must now be extended to a much wider phylogenetic range of flowering plants and, indeed, to their closest living relatives, the gymnosperms. Studies of further, more wide-ranging models should provide insights that, for various reasons, cannot be obtained by studying the major existing models alone. The use of further models should also help to explain how the first flowering plants evolved from an unknown, although presumably gymnosperm-like ancestor, and rapidly diversified to become the largest major plant group and to dominate the terrestrial flora. The benefits for society of a thorough understanding of flower development are self-evident, as human life depends to a large extent on flowering plants and on the fruits and seeds they produce. In this preface to the Special Issue, we introduce eleven articles on flower development, representing work in both established and further models, including gymnosperms. We also present some of our own views on current trends and future directions of the

  10. Positron Computed Tomography: Current State, Clinical Results and Future Trends

    Science.gov (United States)

    Schelbert, H. R.; Phelps, M. E.; Kuhl, D. E.

    1980-09-01

    An overview is presented of positron computed tomography: its advantages over single photon emission tomography, its use in metabolic studies of the heart and chemical investigation of the brain, and future trends. (ACR)

  11. Current market trends in hospital/physician integration.

    Science.gov (United States)

    Bauman, Randy R

    2009-01-01

    This article explores recent trends that are dramatically changing the landscape of typical hospital/physician integration models and provides the reader with useful insights to better evaluate this dynamically changing marketplace.

  12. State Education Spending: Current Pressures and Future Trends

    OpenAIRE

    Sheila E. Murray; Rueben, Kim; Rosenberg, Carol

    2007-01-01

    Education expenditures are one of the largest spending areas for state and local governments, and per–pupil expenditures have been growing over time. We examine trends in state aid for education and overall education spending and decompose the existing drivers behind growing state costs. We then explore how predicted future demographic trends will affect education spending levels, as the percent of the population that is of school age falls. We conclude that there will continue to be a large ...

  13. Monolith ERP and current IT-trends : Creating a step by step development model (SSDM) for existing monolith ERP system to adapt to the current IT-trends

    OpenAIRE

    Vuorenmaa, Riku

    2015-01-01

    ERP systems have been around for 25 years and have gone through evolution phases. None of the previous phases have however imposed so big a challenge and opportunities for the ERP producers / vendors as current outsourcing and cloud computing trends. Current traditional on-premises (monolith) ERP systems are put under pressure to cope with the demands imposed by cloud computing and other IT-trends (such as mobility). Traditional ERP systems have to adapt or face a risk of becoming obsolete. ...

  14. Josephson and persistent spin currents in Bose-Einstein condensates of magnons

    Science.gov (United States)

    Nakata, Kouki; van Hoogdalem, Kevin A.; Simon, Pascal; Loss, Daniel

    2014-10-01

    Using the Aharonov-Casher (A-C) phase, we present a microscopic theory of the Josephson and persistent spin currents in quasiequilibrium Bose-Einstein condensates (BECs) of magnons in ferromagnetic insulators. Starting from a microscopic spin model that we map onto a Gross-Pitaevskii Hamiltonian, we derive a two-state model for the Josephson junction between the weakly coupled magnon-BECs. We then show how to obtain the alternating-current (ac) Josephson effect with magnons as well as macroscopic quantum self-trapping in a magnon-BEC. We next propose how to control the direct-current (dc) Josephson effect electrically using the A-C phase, which is the geometric phase acquired by magnons moving in an electric field. Finally, we introduce a magnon-BEC ring and show that persistent magnon-BEC currents flow due to the A-C phase. Focusing on the feature that the persistent magnon-BEC current is a steady flow of magnetic dipoles that produces an electric field, we propose a method to directly measure it experimentally.

  15. Will current trends close major crop yield gaps by 2025?

    Science.gov (United States)

    Ray, D. K.; Mueller, N. D.; Gerber, J. S.; Johnston, M.; Foley, J. A.

    2012-12-01

    Several studies have projected a need to double global agricultural production by 2050 to meet the demands posed by population growth, increased dairy and meat consumption, and biofuel use. However, recent work shows many regions where there are shortfalls in production compared to the regions with the highest yield. While these "yield gaps" could be closed through more intensive and advanced management, already between 24% and 39% of the global crop growing regions are witnessing yield stagnation. In this presentation we will identify the areas across the globe where yield gaps (as quantified circa the year 2000) are projected to either close or persist given observed rates of yield increases. Major investments in better management are needed in areas where yield gaps are projected to persist.

  16. Hispanic Superintendents in Illinois: Current Trends and Challenges

    Science.gov (United States)

    Espinoza, Ricardo

    2012-01-01

    The trends and challenges faced by Hispanic superintendents in Illinois are stated and analyzed throughout the study in both literature and practice. The examined items centered on the issues of hiring experiences and other barriers associated with the acquisition and longevity of the superintendency in Illinois. Data for the study were collected…

  17. Teachers' Attitudes Toward Current Trends in Foreign Language Instruction

    Science.gov (United States)

    Papalia, Anthony

    1977-01-01

    Teachers' attitudes toward language teaching trends were surveyed. Prospective teachers about to enter the profession believed that language programs should be self-paced and there should be a cooperative learning climate in classrooms. Experienced teachers were more moderate but used techniques for self-pacing and real communication often in…

  18. African American Youth Unemployment: Current Trends and Future Prospects.

    Science.gov (United States)

    Hunter, Herbert M.

    1990-01-01

    Examines African American employment trends compared with increases or decreases in economic growth and Federal welfare spending during the 1970s and 1980s, focusing primarily on unemployment and labor force participation rates among African American youth. Studies the impact of structural unemployment, racial discrimination, and immigration on…

  19. Assessment and E-Learning: Current Issues and Future Trends

    Science.gov (United States)

    Cowie, Neil; Sakui, Keiko

    2015-01-01

    This paper describes different ways in which digital technology can be used for language learning. It then identifies some key trends connecting assessment and technology in language learning and higher education: the use of automated systems to enhance traditional assessment practices; the use of Web 2.0 tools to facilitate new assessment…

  20. Materials for hydrogen storage: current research trends and perspectives.

    Science.gov (United States)

    van den Berg, Annemieke W C; Areán, Carlos Otero

    2008-02-14

    Storage and transport of hydrogen constitutes a key enabling technology for the advent of a hydrogen-based energy transition. Main research trends on hydrogen storage materials, including metal hydrides, porous adsorbents and hydrogen clathrates, are reviewed with a focus on recent developments and an appraisal of the challenges ahead. .

  1. Institutional Repositories at Small Institutions in America: Some Current Trends

    Science.gov (United States)

    Nykanen, Melissa

    2011-01-01

    The research reported in this article was undertaken to determine the level of implementation of institutional repositories (IRs) at small institutions enrolling fewer than 10,000 students. The study analyzed quantitative and qualitative data from IRs at a number of small institutions with the aim of observing relevant patterns and trends that may…

  2. Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.

    Science.gov (United States)

    Aman, Teresa K; Grieco-Calub, Tina M; Chen, Chunling; Rusconi, Raffaella; Slat, Emily A; Isom, Lori L; Raman, Indira M

    2009-02-18

    The beta subunits of voltage-gated Na channels (Scnxb) regulate the gating of pore-forming alpha subunits, as well as their trafficking and localization. In heterologous expression systems, beta1, beta2, and beta3 subunits influence inactivation and persistent current in different ways. To test how the beta4 protein regulates Na channel gating, we transfected beta4 into HEK (human embryonic kidney) cells stably expressing Na(V)1.1. Unlike a free peptide with a sequence from the beta4 cytoplasmic domain, the full-length beta4 protein did not block open channels. Instead, beta4 expression favored open states by shifting activation curves negative, decreasing the slope of the inactivation curve, and increasing the percentage of noninactivating current. Consequently, persistent current tripled in amplitude. Expression of beta1 or chimeric subunits including the beta1 extracellular domain, however, favored inactivation. Coexpressing Na(V)1.1 and beta4 with beta1 produced tiny persistent currents, indicating that beta1 overcomes the effects of beta4 in heterotrimeric channels. In contrast, beta1(C121W), which contains an extracellular epilepsy-associated mutation, did not counteract the destabilization of inactivation by beta4 and also required unusually large depolarizations for channel opening. In cultured hippocampal neurons transfected with beta4, persistent current was slightly but significantly increased. Moreover, in beta4-expressing neurons from Scn1b and Scn1b/Scn2b null mice, entry into inactivated states was slowed. These data suggest that beta1 and beta4 have antagonistic roles, the former favoring inactivation, and the latter favoring activation. Because increased Na channel availability may facilitate action potential firing, these results suggest a mechanism for seizure susceptibility of both mice and humans with disrupted beta1 subunits.

  3. Current State and Development Trends for Integration Platforms

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The integration platform (IP) is an advanced support tool for application softwa re development and integration. This paper analyzes the shortcomings of traditio nal software programming methods, introduces the background and development of i ntegration platforms and presents the basic functions and system architecture of computer integrated manufacture computing environment (CCE) IP as well as the i ntegration framework. Computer integrated manufacturing system (CIMS) applicatio n IP is defined i n relation to the IP requirements for CIMS implementation within a company. The CIMS application IP is not only a support tool for application software developm ent, but also a support tool for software integration and system operation. Ther efore, the behavior and functions of a CIMS application IP must also include sof tware integration and system operation. The development trend for CIMS applicati on IPs is discussed in view of software technology development trends.

  4. Current and Future Trends in Game-Based Learning

    Directory of Open Access Journals (Sweden)

    Carlos Vaz de Carvalho

    2014-05-01

    Full Text Available The first number of the second volume of the EAI Transactions on Serious Games focuses on the results presented on the European Conference on Game-Based Learning. This event, already on the 8th edition, has set standards in terms of presentation of research and practice and in the pointing out of new and future trends in the development of Game-Based Learning. As such, we are quite thrilled to be able to report them here.

  5. Current and future trends in metagenomics : Development of knowledge bases

    Science.gov (United States)

    Mori, Hiroshi; Yamada, Takuji; Kurokawa, Ken

    Microbes are essential for every part of life on Earth. Numerous microbes inhabit the biosphere, many of which are uncharacterized or uncultivable. They form a complex microbial community that deeply affects against surrounding environments. Metagenome analysis provides a radically new way of examining such complex microbial community without isolation or cultivation of individual bacterial community members. In this article, we present a brief discussion about a metagenomics and the development of knowledge bases, and also discuss about the future trends in metagenomics.

  6. Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis.

    Science.gov (United States)

    Pieri, Massimo; Carunchio, Irene; Curcio, Livia; Mercuri, Nicola Biagio; Zona, Cristina

    2009-02-01

    Cortical hyperexcitability has been observed in Amyotrophic Lateral Sclerosis (ALS) patients. Familial ALS accounts for 10% of all cases and mutations of the Cu,Zn superoxide dismutase (SOD1) gene have been identified in about 20% of the familial cases. The aim of this study was to investigate whether in a mouse model of ALS the cortical neurons developed hyperexcitability due to intrinsic properties of the single cell. We first examined the passive membrane properties and the pattern of repetitive firing in cultured cortical neurons from Control mice and transgenic mice expressing high levels of the human mutated protein (Gly(93)-->Ala, G93A). The former did not display significantly differing values between Control and G93A cortical neurons. However, the threshold potential and time of the first action potential decreased significantly and the firing frequency increased significantly in the G93A compared to Control neurons. The analysis of the voltage-dependent sodium currents revealed that the fast transient sodium current was unaffected by the SOD1 mutation whereas the persistent sodium current was significantly higher in the mutated neurons. Finally, Riluzole, a selective blocker of the persistent sodium current at low concentrations, decreased the firing frequency in G93A neurons, strongly indicating an involvement of this current in the observed hyperexcitability. These are the first data that demonstrate an intrinsic hyperexcitability in the G93A cortical neurons due to a higher current density of the persistent sodium current in the mutated neurons and open up new prospects of understanding ALS disease etiopathology.

  7. A twenty-one year temporal trend of persistent organic pollutants in St. Lawrence Estuary beluga, Canada.

    Science.gov (United States)

    Lebeuf, Michel; Measures, Lena; Noël, Michelle; Raach, Meriem; Trottier, Steve

    2014-07-01

    Persistent organic pollutants (POPs) were measured in blubber from 144 stranded adult belugas (Delphinapterus leucas) found on the shores of the St. Lawrence Estuary (SLE) between 1987 and 2007. Temporal trends of POP concentrations (ln transformed) in beluga were described by three models, zero slope (ZS), linear (L) and two-segment piecewise (PW). Often two but sometimes all three models were equivalent in describing temporal trends based on Akaike's Information Criterion for small sample sizes. Over this 21-year time period, concentrations of most legacy POPs, including PCBs, DDTs and HCHs, exhibited relatively weak (≤11% per year) but significant decreasing trends in beluga. For PBDEs, temporal trends were best described by a PW model, characterizing a rapid increase until 1997-1998 followed by a slower increase for males and a steady-state for females. Potential cofactors such as blubber lipid content and carcass state of preservation did not show any significant temporal trends over the time period considered. Nitrogen stable isotope ratios (δ(15)N) in beluga liver, a proxy of trophic level, could not be associated to any effect on temporal trends of POP concentrations in beluga. Several POPs exhibited significant relationships with age of beluga and data were age-adjusted. Temporal trends of POP concentrations adjusted for age of beluga were reassessed but results were essentially identical as those obtained with the original POP data. Overall, POP temporal trends observed in SLE beluga are consistent with changes expected from regulations and restrictions in the use of these compounds in developed countries.

  8. Current and Future Trends of the Automotive Industry

    Directory of Open Access Journals (Sweden)

    Dieter Hermann Schramm

    2015-12-01

    Full Text Available Mobility, and especially individual physical mobility, is still an essential component of nearly all societies.The combustion engine was for more than a hundred years, and is still today, the backbone of road-based mobility. However, the guarantor for the triumphant advance of the combustion engine was by far not its technical superiority over its electrical rival at the beginning of the automobile era, but the energy density and the easy worldwide availability of fossil fuels as a means of energy storage. So, e.g. to store theenergy equivalent of one kg Gasoline, a lithium ion battery with a mass of about 180 kg would be required (Schramm, 2012, even if the higher efficiency of the electric motor vs. the combustion engine is taken into account. Actually an electric motor is much better suited as a drive source for a motor vehicle as an internal combustion engine. Only the achievable energy density along with the cost of its chemical-process based storage, the battery, still prevent its immediate breakthrough in the automotive drive technology.Nevertheless, the German Government has set the target to bring at least a million electrified motor vehicles on Germany's roads by 2020, which is already impossible to reach from today’s perspective.However, strategies are needed to achieve a sustainable transition to electric mobility. This, in addition to continued research on high-efficiency batteries which also includes the development of vehicles that offer a good compromise between coverage, costs and consumption while satisfying the mobility needs of their users.Another trend that will lead to a paradigm shift in the use of individually-powered vehicles is the automation of the task of driving up to the highly automated or even autonomous vehicle. The technical prerequisites like sensors and actuators for these new systems are already available at least for application on motorways and rural regions, e.g. in Germany. More activities

  9. [Current trends in marriage and divorce rates in Europe].

    Science.gov (United States)

    Sugareva, M

    1986-01-01

    A comparative study of marriage and divorce rates in Europe is presented, with particular reference to Bulgaria. The author notes that the marriage rate is declining in most Western European countries, particularly in Scandinavia, and associates this trend with the growing popularity of consensual unions. Some terminology problems concerning this phenomenon are discussed. No significant decline in the marriage rate in Bulgaria is apparent; divorce rates are on the increase, but are still lower than in most other European countries. (SUMMARY IN ENG AND RUS)

  10. Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli.

    Science.gov (United States)

    Thor, Michael G; Morris, Gareth

    2016-11-01

    The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current (INaP) and the h-current (Ih), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean (J Neurophysiol 114: 2376-2389, 2015) used pharmacological methods to discern the roles of Ih and INaP at subthreshold voltages during naturalistic stimuli. We discuss these findings in the context of dorsoventral heterogeneity in the hippocampus and suggest further applications of the method.

  11. Giant Persistent Current in a Mesoscopic Ring with Parallel-Coupled Double Quantum Dots

    Institute of Scientific and Technical Information of China (English)

    CHEN Xiong-Wen; WU Shao-Quan; WANG Peng; SUN Wei-Li

    2004-01-01

    @@ We theoretically study the properties of the ground state of the parallel-coupled double quantum dots embedded in a mesoscopic ring in the Kondo regime by means of the two-impurity Anderson Hamiltonian. The Hamiltonian is solved by means of the slave-boson mean-field theory. Our results show that in this system, the persistent current depends sensitively on both the parity of this system and the size of the ring. Two dots can be coupled coherently, which is reflected in the giant current peak in the strong coupling regime. This system might be a candidate for future device applications.

  12. Everyday, everywhere: alcohol marketing and social media--current trends.

    Science.gov (United States)

    Nicholls, James

    2012-01-01

    To provide a snapshot content analysis of social media marketing among leading alcohol brands in the UK, and to outline the implications for both regulatory policies and further research. Using screengrab technology, the complete Facebook walls and Twitter timelines for 12 leading UK alcohol brands in November 2011 were captured and archived. A total of 701 brand-authored posts were identified and categorized using a thematic coding frame. Key strategic trends were identified and analysed in the light of contextual research into recent developments in marketing practice within the alcohol industry. A number of dominating trends were identified. These included the use of real-world tie-ins, interactive games, competitions and time-specific suggestions to drink. These methods reflect a strategy of branded conversation-stimulus which is favoured by social media marketing agencies. A number of distinct marketing methods are deployed by alcohol brands when using social media. These may undermine policies which seek to change social norms around drinking, especially the normalization of daily consumption. Social media marketing also raises questions regarding the efficacy of reactive regulatory frameworks. Further research into both the nature and impact of alcohol marketing on social media is needed.

  13. CURRENT DEMOGRAPHIC TRENDS AND THEIR GEOPOLITICAL AND STRATEGIC REPERCUSSIONS

    Directory of Open Access Journals (Sweden)

    Ionel STOICA

    2014-10-01

    Full Text Available Major worldwide demographic trends impact significantly each aspect of people’s lives. The impact will be favorable for some states and completely unfavorable for others since they will depend not only on the magnitude of these tendencies, but also on the aggregated result of the inherent shifts and developments at political, economic, social and military level Global demographic trends will represent a genuine challenge for the powerful states to maintain the existing global political and economic equilibrium and they will also constitute a genuine shocking force for international security and stability. At the same time, they will represent one of the variables underpinning states’ strategies, and domestic and foreign policies and influencing political and military alliances in the future. It is likely that they will lead to the reassessment of the bases of international relations. This paper analyzes the presumed consequences of future demographic shifts on the economic, political, military field and proposes some possible solutions to efficiently manage the issue.

  14. The epidemiology of HIV/AIDS in Minnesota: current trends.

    Science.gov (United States)

    Bonham, Shulamith; Alozie, Ogechika K; Henry, W Keith

    2009-10-01

    The epidemic of HIV infection and HIV/AIDS in Minnesota reflects national trends in transmission and progression to disease. Analysis of Minnesota's data also highlights populations that are at much greater risk for HIV infection and progression to AIDS. Although men who have sex with men continue to comprise the majority of people in Minnesota with HIV, other subpopulations--women, people of color, and foreign-born residents--are seeing a rise in their infection rates as well. Members of these groups tend to be diagnosed later and, thus, are at greater risk for their infection to progress to AIDS. This article discusses some of the nuances of the most recent epidemiologic data on HIV/AIDS in Minnesota and makes the case for continued aggressive strategies for outreach, education, and adequate access to health care services among at-risk populations.

  15. Current trends in the clinical development of peptide therapeutics.

    Science.gov (United States)

    Saladin, Pauline M; Zhang, Bodi D; Reichert, Janice M

    2009-12-01

    The development of peptides as drugs is attracting increasing attention from the pharmaceutical industry. This interest is at least partially a consequence of the widespread acceptance of therapeutic proteins by physicians and patients, and because of improvements to problems such as a short half-life and delivery issues. The markets for peptide-based compounds can be substantial, with six peptide drugs attaining global sales of more than US $750 million in 2008. To track trends in the clinical development and marketing approval of peptides, Tufts Center for the Study of Drug Development and Ferring Research Institute compiled publically available data for peptides that entered clinical trials sponsored by commercial firms, with a focus on peptide therapeutics, but also including peptide vaccines and diagnostics. The results provide an historical overview of the development of peptide therapeutics, and may inform strategic planning in this area.

  16. Microplastics in the marine environment: Current trends and future perspectives.

    Science.gov (United States)

    Barboza, Luís Gabriel Antão; Gimenez, Barbara Carolina Garcia

    2015-08-15

    Over the last decade, the presence of microplastics on marine environments has become an important environmental concern and focus of interest of many researches. Thus, to provide a more integrated view of the research trends regarding this topic, we use a scientometric approach to systematically assess and quantify advances in knowledge related to microplastics in the marine environment. The papers that we used for our assessment were obtained from the database Thomson Reuters (ISI Web of Science), between 2004 and 2014. Our results reveal the overall research performance in the study area of microplastics present in the marine environment over the past decade as a newly developed research field. It has been recognized that there are several important issues that should be investigated. Toward that end, based on the suggested directions on all papers reviewed, we point out areas/topics of interest that may guide future work in the coming years.

  17. New Methods, Current Trends and Software Infrastructure for NLP

    CERN Document Server

    Cunningham, H; Gaizauskas, R J; Cunningham, Hamish; Wilks, Yorick; Gaizauskas, Robert J.

    1996-01-01

    The increasing use of `new methods' in NLP, which the NeMLaP conference series exemplifies, occurs in the context of a wider shift in the nature and concerns of the discipline. This paper begins with a short review of this context and significant trends in the field. The review motivates and leads to a set of requirements for support software of general utility for NLP research and development workers. A freely-available system designed to meet these requirements is described (called GATE - a General Architecture for Text Engineering). Information Extraction (IE), in the sense defined by the Message Understanding Conferences (ARPA \\cite{Arp95}), is an NLP application in which many of the new methods have found a home (Hobbs \\cite{Hob93}; Jacobs ed. purposes, and this is described. Lastly we review related work.

  18. On the dynamics of persistent states and their secular trends in the waveguides of the Southern Hemisphere troposphere

    Science.gov (United States)

    O'Kane, Terence J.; Risbey, James S.; Monselesan, Didier P.; Horenko, Illia; Franzke, Christian L. E.

    2016-06-01

    We identify the dynamical drivers of systematic changes in persistent quasi-stationary states (regimes) of the Southern Hemisphere troposphere and their secular trends. We apply a purely data-driven approach, whereby a multiscale approximation to nonstationary dynamical processes is achieved through optimal sequences of locally stationary fast vector autoregressive factor processes, to examine a high resolution atmospheric reanalysis over the period encompassing 1958-2013. This approach identifies regimes and their secular trends in terms of the predictability of the flow and is Granger causal. A comprehensive set of diagnostics on both isentropic and isobaric surfaces is employed to examine teleconnections over the full hemisphere and for a set of regional domains. Composite states for the hemisphere obtained from nonstationary nonparametric cluster analysis reveal patterns consistent with a circumglobal wave 3 (polar)-wave 5 (subtropical) pattern, while regional composites reveal the Pacific South American pattern and blocking modes. The respective roles of potential vorticity sources, stationary Rossby waves and baroclinic instability on the dynamics of these circulation modes are shown to be reflected by the seasonal variations of the waveguides, where Rossby wave sources and baroclinic disturbances are largely contained within the waveguides and with little direct evidence of sustained remote tropical influences on persistent synoptic features. Warm surface temperature anomalies are strongly connected with regions of upper level divergence and anticyclonic Rossby wave sources. The persistent states identified reveal significant variability on interannual to decadal time scales with large secular trends identified in all sectors apart from a region close to South America.

  19. Current trends in the treatment of hepatic encephalopathy

    Directory of Open Access Journals (Sweden)

    Mohamad Rasm Al Sibae

    2009-07-01

    Full Text Available Mohamad Rasm Al Sibae, Brendan M McGuireDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USAAbstract: Hepatic encephalopathy (HE is a common reversible neuropsychiatric syndrome associated with chronic and acute liver dysfunction and significant morbidity and mortality. Although a clear pathogenesis is yet to be determined, elevated ammonia in the serum and central nervous system are the mainstay for pathogenesis and treatment. Management includes early diagnosis and prompt treatment of precipitating factors (infection, gastrointestinal bleeding, electrolyte disturbances, hepatocellular carcinoma, dehydration, hypotension, and use of benzodiazepines, psychoactive drugs, and/or alcohol. Clinical trials have established the efficacy of lactulose and lactitol enemas in the treatment of acute hepatic encephalopathy. Extensive clinical experience has demonstrated the efficacy of oral lactulose and lactitol with the goal of two to three soft bowel movements a day for the treatment of chronic HE. However, lactulose and lactitol have significant gastrointestinal side effects. For patients unable to tolerate lactulose or lactitol or who still have persistent chronic HE with lactulose or lactitol, neomycin, metronidazole and rifaximin are second-line agents. More recent data supports the benefits of rifaximin used solely and as an additional agent with fewer side effects than neomycin or metronidazole. Newer therapies being investigated in humans with clinical promise include nitazoxanide, the molecular adsorbent recirculating system (MARS, L-ornithine phenylacetate, sodium benzoate, and/or sodium phenylacetate and Kremezin® (AST-120.Keywords: hepatic encephalopathy, liver dysfunction, lactulose, lactitol

  20. Vibrio cholerae: A historical perspective and current trend

    Directory of Open Access Journals (Sweden)

    Mary Oyenike Oladokun

    2016-11-01

    Full Text Available Vibrio cholerae (V. cholerae is a Gram-negative, curved, rod-shaped bacteria with two of its strains V. cholerae O1 and V. cholerae O139 known to cause cholera, a deadly diarrheal disease that has repeatedly plagued the world in pandemics since 1817 and still remains a public health problem globally till today. The pathogens’ persistence in aquatic milieux during inter-epidemic periods is facilitated by the production of a biofilm, thus evolving from being an infection of oral-fecal transmission to a more composite ecological framework of a communicable disease. The outbreaks of cholera spread rapidly in various intensities within and among countries and even continents and the World Health Organization estimates that 3–5 million cases outbreak and over 200 000 die yearly from cholera. Also, the impact of a cholera epidemic is not limited to its high morbidity and mortality rates alone, but also the grievous impact on the economy of the countries experiencing the outbreaks. In this review, we carried out an overview of V. cholerae including its isolation and detection, genetics as well as a comparison of the toxigenic and non-toxigenic determinants in the human host and the host defences. Furthermore, the history of global pandemics, cost implications, conflict and ecological methodologies of cholera prevention and control. The management of disease and antibiotic resistance in V. cholerae are also highlighted.

  1. Current trends in Latin America and the Argentine perspective

    Energy Technology Data Exchange (ETDEWEB)

    Laredo, V.G. [SOCMA Americana, Buenos Aires (Argentina)

    1992-12-31

    The authors discusses the changes that are taking place in Argentina as well as in all of Latin America today -- privatization, deregulation, and the modernization of the economy, changes which will serve to strengthen the governments and provide a better quality of life for all of them. He gives an insight into the factors which helped bring about these changes, the support they are receiving, the problems which persist, and the measures that still must be taken so that these positive changes remain in place. He offers some useful information that will perhaps contribute to their understanding of the vast area which he refers to as Latin America, and more specifically, gives a thumbnail sketch of what is happening today in the Republic of Argentina. For many years now, Latin American leaders have travelled to other parts of the world and spoken about the plans and expectations for the region`s future. When these well-intentioned projects and plans never materialized, partners and supporters in the United States and other countries were frustrated and disappointed by the failure to make things work. The author`s intention here today is to describe things as they are, not as they might be, to tell about what is already happening in the sphere of business and growth of the economies in Latin America.

  2. Hyperthyroidism in Graves disease. Current trends in management and diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Haibach, H.

    1976-06-01

    The radioimmunoassay for T/sub 3/ is now widely available and is a useful diagnostic tool for hyperthyroidism, especially in T/sub 3/-thyrotoxicosis. It is an essential tool in the management of hyperthyroidism that persists after treatment with normal T/sub 4/ serum levels or, in euthyroid cases, with low T/sub 4/ serum levels. In these conditions, it reflects the metabolic state more accurately than serum levels of T/sub 4/. A promising new test is the response of radioimmunoassayable TSH to protirelin relin (TRH) administration. An absent response indicates pituitary suppression and thyroid autonomy as seen in frank hyperthyroidism or euthyroid Graves disease, treated or untreated. It is safer and quicker than the conventional T/sub 3/ suppression test of thyroid radioactive iodine uptake and may replace it at least partly in the future. The recently recognized sharp decline in the remission rate of patients subjected to thyroid drug therapy in the last decade has made this treatment much less efficacious. By necessity, it will probably lead to greater reliance on treatment with radioactive iodine in the majority of the patients with the hyperthyroidism of Graves disease.

  3. Water quality, agriculture and food safety in China:Current situation, trends, interdependencies, and management

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiao-nan; GUO Qiu-ping; SHEN Xiao-xue; YU Sheng-wen; QIU Guo-yu

    2015-01-01

    Water quality in China is becoming a severe chalenge for agriculture and food safety, and it might also impact health of populationvia agriculture and food. Thus, it is causing widespread concern. Based on extensive literatures review and data mining, current situation of water polution in China and its effects on food safety were analyzed.The 2nd National Water Resource Survey in China show that the surface water al over the country was under slight polution and about 60% of groundwater is poluted. Drinking water quality is basicaly guaranteed in urban area but it is worrisome in rural areas. In addition, China is the largest consumer of fertilizer and pesticide in the world and the amounts of application stil show increasing trends. Fertilizers and pesticides are the most important sources of polution, which affect human health as persistent organic polutants and environmental endocrine disruptors. Eutrophication of surface water and nitrate polution of groundwater are serious threats to drinking water safety. Sewage irrigation is becoming a polution source to China’s water and land because of lacking of effective regulations. Although, with the advance in technology and management level, control of nitrogen and phosphorus emissions and reducing water polution is stil a major chalenge for China.

  4. Current trends in the cardiovascular clinical trial arena (I

    Directory of Open Access Journals (Sweden)

    Pater Cornel

    2004-06-01

    Full Text Available Abstract The existence of effective therapies for most cardiovascular disease states, coupled with increased requirements that potential benefits of new drugs be evaluated on clinical rather than surrogate endpoints, makes it increasingly difficult to substantiate any incremental improvements in efficacy that these new drugs might offer. Compounding the problem is the highly controversial issue of comparing new agents with placebos rather than active pharmaceuticals in drug efficacy trials. Despite the recent consensus that placebos may be used ethically in well-defined, justifiable circumstances, the problem persists, in part because of increased scrutiny by ethics committees but also because of considerable lingering disagreement regarding the propriety and scientific value of placebo-controlled trials (and trials of antihypertensive drugs in particular. The disagreement also substantially affects the most viable alternative to placebo-controlled trials: actively controlled equivalence/noninferiority trials. To a great extent, this situation was prompted by numerous previous trials of this type that were marked by fundamental methodological flaws and consequent false claims, inconsistencies, and potential harm to patients. As the development and use of generic drugs continue to escalate, along with concurrent pressure to control medical costs by substituting less-expensive therapies for established ones, any claim that a new drug, intervention, or therapy is "equivalent" to another should not be accepted without close scrutiny. Adherence to proper methods in conducting studies of equivalence will help investigators to avoid false claims and inconsistencies. These matters will be addressed in the third article of this three-part series.

  5. Laser-induced incandescence : recent trends and current questions

    NARCIS (Netherlands)

    Schulz, C.; Kock, B.F.; Hofmann, M.; Michelsen, H.; Will, S.; Bougie, B.; Suntz, R.; Smallwood, G.

    2006-01-01

    This paper provides an overview of a workshop focused on fundamental experimental and theoretical aspects of soot measurements by laser-induced incandescence (LII). This workshop was held in Duisburg, Germany in September 2005. The goal of the workshop was to review the current understanding of the

  6. Laser-induced incandescence : recent trends and current questions

    NARCIS (Netherlands)

    Schulz, C.; Kock, B.F.; Hofmann, M.; Michelsen, H.; Will, S.; Bougie, B.; Suntz, R.; Smallwood, G.

    2006-01-01

    This paper provides an overview of a workshop focused on fundamental experimental and theoretical aspects of soot measurements by laser-induced incandescence (LII). This workshop was held in Duisburg, Germany in September 2005. The goal of the workshop was to review the current understanding of the

  7. Current trends in endodontic practice: emergency treatments and technological armamentarium.

    Science.gov (United States)

    Lee, Michelle; Winkler, Johnathon; Hartwell, Gary; Stewart, Jeffrey; Caine, Rufus

    2009-01-01

    The current clinical practice of endodontics includes the utilization of a variety of new technological advances and materials. The last comprehensive survey that compared treatment modalities used in endodontic practices was conducted in 1990. The purpose of the current survey was to determine the frequency with which these new endodontic technologies and materials are being used in endodontic practices today. An e-mail questionnaire was sent to the 636 active diplomates of the American Board of Endodontics with current e-mail addresses. Two hundred thirty-two diplomates responded for a response rate of 35%. Calcium hydroxide was found to be the most frequently used intracanal medicament for all cases diagnosed with necrotic pulps. Ibuprofen was the most frequently prescribed medication for pain, and penicillin was the most frequently prescribed antibiotic when an active infection was present. Eighty-two percent of the respondents are still incorporating hand files in some fashion during the cleansing and shaping phase of treatment. Lateral condensation and continuous wave were the most common methods used for obturation. Digital radiography was reported as being used by 72.5% of the respondents, whereas 45.3% reported using the microscope greater than 75% of the patient treatment. Ultrasonics was used by 97.8% of the respondents. It appears from the results that new endodontic technology is currently being used in the endodontic offices of those who responded to the survey.

  8. Current HRD trends in the Netherlands: Conceptualisation and practices

    NARCIS (Netherlands)

    Kwakman, C.H.E.; Streumer, Jan; van der Heijden, Beatrice; Wognum, Ida; van Zolingen, S.J.

    2002-01-01

    In this contribution, we first report on a literature study aimed at describing current HRD developments. The resulting literature report was presented to a group of experts in the field of HRD. The participants were asked to sketch their vision as to the relevance of the HRD developments for their

  9. Current HRD trends in the Netherlands : conceptualizing and practices

    NARCIS (Netherlands)

    Kwakman, C.H.E.; Streumer, J.N.; Heijden, B.I.J.M. van der; Wognum, A.A.M.; Zolingen, S.J. van

    2002-01-01

    In this contribution, we first report on a literature study aimed at describing current HRD developments. The resulting literature report was presented to a group of experts in the field of HRD. The participants were asked to sketch their vision as to the relevance of the HRD developments for their

  10. Online Current-Events Retrieval Services: Developments and Trends.

    Science.gov (United States)

    Smith, Stephen C.

    1984-01-01

    Summary of developments that have occurred in the past year in online news-retrieval services highlights the demise of the New York Times Information Service, Information Access Corporation's database additions and enhancements, full-text services, specialized databases with current events content, and microcomputer access to news. Twelve…

  11. The International Curriculum: Current Trends and Emerging Needs

    Science.gov (United States)

    Richter, Jesse Jones

    2015-01-01

    This paper examines the current state of tertiary level international curricula and provides groundwork for future research aimed at ongoing needs. Recognized is the premise that existing international curricular programs require maintenance. Burn (1995) called for curriculum reform in international departments two decades ago with the rationale…

  12. FBG-Based Monitoring of Geohazards: Current Status and Trends.

    Science.gov (United States)

    Zhu, Hong-Hu; Shi, Bin; Zhang, Cheng-Cheng

    2017-02-24

    In recent years, natural and anthropogenic geohazards have occured frequently all over the world, and field monitoring is becoming an increasingly important task to mitigate these risks. However, conventional geotechnical instrumentations for monitoring geohazards have a number of weaknesses, such as low accuracy, poor durability, and high sensitivity to environmental interferences. In this aspect, fiber Bragg grating (FBG), as a popular fiber optic sensing technology, has gained an explosive amount of attention. Based on this technology, quasi-distributed sensing systems have been established to perform real-time monitoring and early warning of landslides, debris flows, land subsidence, earth fissures and so on. In this paper, the recent research and development activities of applying FBG systems to monitor different types of geohazards, especially those triggered by human activities, are critically reviewed. The working principles of newly developed FBG sensors are briefly introduced, and their features are summarized. This is followed by a discussion of recent case studies and lessons learned, and some critical problems associated with field implementation of FBG-based monitoring systems. Finally the challenges and future trends in this research area are presented.

  13. Personal trainer demographics, current practice trends and common trainee injuries

    Directory of Open Access Journals (Sweden)

    Gregory R. Waryasz

    2016-10-01

    Full Text Available Increasing emphasis on maintaining a healthy lifestyle has led many individuals to seek advice on exercise from personal trainers. There are few studies to date that evaluate personal trainer education, practice trends, and injuries they have seen while training clients. A survey was distributed to personal trainers using Survey Monkey® (Palo Alto, CA, USA with 605 personal trainers accessing the survey. An exercise related bachelor’s degree was held by 64.2% of survey participants and a certification in personal training by 89.0%. The most common personal trainer certifications were from American College of Sports Medicine (59.2% and National Strength and Conditioning Association (28.9%. Only 2.9% of all personal trainers surveyed had no exercise-related bachelor’s degree and no personal trainer certification. The most common injuries seen by personal trainers during sessions were lumbar muscle strain (10.7%, rotator cuff tear/tendonitis (8.9%, shin splints (8.1%, ankle sprain (7.5%, and cervical muscle strain (7.4%. There is variability in the practices between different personal trainers when analyzing differences in collegiate education, personal trainer certifications, and strength and conditioning certifications. The clinical implication of the differences in practices is unknown as to the impact on injuries or exercise prescription effectiveness.

  14. Personal Trainer Demographics, Current Practice Trends and Common Trainee Injuries

    Science.gov (United States)

    Waryasz, Gregory R.; Daniels, Alan H.; Gil, Joseph A.; Suric, Vladimir; Eberson, Craig P.

    2016-01-01

    Increasing emphasis on maintaining a healthy lifestyle has led many individuals to seek advice on exercise from personal trainers. There are few studies to date that evaluate personal trainer education, practice trends, and injuries they have seen while training clients. A survey was distributed to personal trainers using Survey Monkey® (Palo Alto, CA, USA) with 605 personal trainers accessing the survey. An exercise related bachelor’s degree was held by 64.2% of survey participants and a certification in personal training by 89.0%. The most common personal trainer certifications were from American College of Sports Medicine (59.2%) and National Strength and Conditioning Association (28.9%). Only 2.9% of all personal trainers surveyed had no exercise-related bachelor’s degree and no personal trainer certification. The most common injuries seen by personal trainers during sessions were lumbar muscle strain (10.7%), rotator cuff tear/tendonitis (8.9%), shin splints (8.1%), ankle sprain (7.5%), and cervical muscle strain (7.4%). There is variability in the practices between different personal trainers when analyzing differences in collegiate education, personal trainer certifications, and strength and conditioning certifications. The clinical implication of the differences in practices is unknown as to the impact on injuries or exercise prescription effectiveness. PMID:27761219

  15. FBG-Based Monitoring of Geohazards: Current Status and Trends

    Directory of Open Access Journals (Sweden)

    Hong-Hu Zhu

    2017-02-01

    Full Text Available In recent years, natural and anthropogenic geohazards have occured frequently all over the world, and field monitoring is becoming an increasingly important task to mitigate these risks. However, conventional geotechnical instrumentations for monitoring geohazards have a number of weaknesses, such as low accuracy, poor durability, and high sensitivity to environmental interferences. In this aspect, fiber Bragg grating (FBG, as a popular fiber optic sensing technology, has gained an explosive amount of attention. Based on this technology, quasi-distributed sensing systems have been established to perform real-time monitoring and early warning of landslides, debris flows, land subsidence, earth fissures and so on. In this paper, the recent research and development activities of applying FBG systems to monitor different types of geohazards, especially those triggered by human activities, are critically reviewed. The working principles of newly developed FBG sensors are briefly introduced, and their features are summarized. This is followed by a discussion of recent case studies and lessons learned, and some critical problems associated with field implementation of FBG-based monitoring systems. Finally the challenges and future trends in this research area are presented.

  16. Consciousness and working memory: Current trends and research perspectives.

    Science.gov (United States)

    Velichkovsky, Boris B

    2017-07-27

    Working memory has long been thought to be closely related to consciousness. However, recent empirical studies show that unconscious content may be maintained within working memory and that complex cognitive computations may be performed on-line. This promotes research on the exact relationships between consciousness and working memory. Current evidence for working memory being a conscious as well as an unconscious process is reviewed. Consciousness is shown to be considered a subset of working memory by major current theories of working memory. Evidence for unconscious elements in working memory is shown to come from visual masking and attentional blink paradigms, and from the studies of implicit working memory. It is concluded that more research is needed to explicate the relationship between consciousness and working memory. Future research directions regarding the relationship between consciousness and working memory are discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Current Trends in Implantable Left Ventricular Assist Devices

    Directory of Open Access Journals (Sweden)

    Jens Garbade

    2011-01-01

    Full Text Available The shortage of appropriate donor organs and the expanding pool of patients waiting for heart transplantation have led to growing interest in alternative strategies, particularly in mechanical circulatory support. Improved results and the increased applicability and durability with left ventricular assist devices (LVADs have enhanced this treatment option available for end-stage heart failure patients. Moreover, outcome with newer pumps have evolved to destination therapy for such patients. Currently, results using nonpulsatile continuous flow pumps document the evolution in outcomes following destination therapy achieved subsequent to the landmark Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure Trial (REMATCH, as well as the outcome of pulsatile designed second-generation LVADs. This review describes the currently available types of LVADs, their clinical use and outcomes, and focuses on the patient selection process.

  18. Current trends in safety testing and toxicological research

    Science.gov (United States)

    Zbinden, G.

    1982-06-01

    The paper reviews current concepts of toxicological evaluation of new drugs and other chemicals. Instead of completing a predetermined check-list toxicologists now consider the potential adverse effects of the substances under actual conditions of use. They then design experimental models which have a high probability to predict the toxic effects. Moreover, the enhanced susceptibilities of special risk populations is more and more taken into consideration.

  19. Current trends in health insurance systems: OECD countries vs. Japan.

    Science.gov (United States)

    Sasaki, Toshiyuki; Izawa, Masahiro; Okada, Yoshikazu

    2015-01-01

    Over the past few decades, the longest extension in life expectancy in the world has been observed in Japan. However, the sophistication of medical care and the expansion of the aging society, leads to continuous increase in health-care costs. Medical expenses as a part of gross domestic product (GDP) in Japan are exceeding the current Organization for Economic Co-operation and Development (OECD) average, challenging the universally, equally provided low cost health care existing in the past. A universal health insurance system is becoming a common system currently in developed countries, currently a similar system is being introduced in the United States. Medical care in Japan is under a social insurance system, but the injection of public funds for medical costs becomes very expensive for the Japanese society. In spite of some urgently decided measures to cover the high cost of advanced medical treatment, declining birthrate and aging population and the tendency to reduce hospital and outpatients' visits numbers and shorten hospital stays, medical expenses of Japan continue to be increasing.

  20. Current Trends in Health Insurance Systems: OECD Countries vs. Japan

    Science.gov (United States)

    SASAKI, Toshiyuki; IZAWA, Masahiro; OKADA, Yoshikazu

    2015-01-01

    Over the past few decades, the longest extension in life expectancy in the world has been observed in Japan. However, the sophistication of medical care and the expansion of the aging society, leads to continuous increase in health-care costs. Medical expenses as a part of gross domestic product (GDP) in Japan are exceeding the current Organization for Economic Co-operation and Development (OECD) average, challenging the universally, equally provided low cost health care existing in the past. A universal health insurance system is becoming a common system currently in developed countries, currently a similar system is being introduced in the United States. Medical care in Japan is under a social insurance system, but the injection of public funds for medical costs becomes very expensive for the Japanese society. In spite of some urgently decided measures to cover the high cost of advanced medical treatment, declining birthrate and aging population and the tendency to reduce hospital and outpatients’ visits numbers and shorten hospital stays, medical expenses of Japan continue to be increasing. PMID:25797778

  1. Current trends in the management of Graves' disease

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, B.; Glinoer, D.; Lagasse, R.; Wartofsky, L. (Walter Reed Army Medical Center, Washington, DC (USA))

    1990-06-01

    Members of the American Thyroid Association were invited to participate in a survey of the management of Graves' disease. One primary case and several variations were provided, which differed in respect to age, sex, goiter size, severity, etc. The questionnaire was based on the format used in a similar survey of members of the European Thyroid Association. The aim of the survey was to determine (1) how expert thyroidologist employ diagnostic procedures for this disorder, and (2) the choice of therapy of the three treatment options and its manner of implementation. Questionnaires were sent only to clinically active members. The overall response rate was 62%. Data analysis was possible on 52% of members surveyed and was performed using SPSS and a specific Fortran program. In the laboratory evaluation of the primary case a radioiodine uptake, scan, serum total T4, and basal TSH were requested by 92%, 47%, 83%, and 66%, respectively, with 84% of respondents using an ultrasensitive TSH assay. For management of the primary case, radioiodine treatment was the first choice of 69% of the respondents. Antithyroid drugs were used briefly (3-7 days) before 131I by 28%, whereas 41% said they would employ thioureas after 131I. Of those using 131I, 66% tailored the dose to achieve euthyroidism as the goal of therapy, while 34% aimed for hypothyroidism requiring T4 replacement. Only 30% of respondents chose thioureas as a first line of treatment (72% propylthiouracil; 28% tapazole). The duration of drug therapy was a predetermined fixed interval for 80% of the respondents, with 90% treating for 1-2 yr. Other specific trends in diagnostic approach and therapeutic preferences were identified for the eight variations on the primary case problem.

  2. Precarious Employment in the Vologda Oblast: Current State and Trends

    Directory of Open Access Journals (Sweden)

    Aleksandr Mikhailovich Panov

    2016-09-01

    Full Text Available The paper is devoted to the study of the phenomenon of precarious employment in Russian regions. Today, the socio-economic sciences lack a single concept of precarious employment applicable to Russian conditions. Despite the considerable amount of scientific and practical works of domestic and foreign authors on the issue of precarious employment, the criteria of its statistical evaluation as applied to Russian conditions have not been determined. At the same time, the development of precarious employment threatens the country’s socio-economic welfare, because it creates the risk of unwanted effects such as poor employment, hidden and open unemployment, lower labor productivity, degradation of human capital, etc. The paper provides a brief review of research on the problem stated, and defines precarious employment. The author makes an attempt to determine and substantiate the list of indicators available in official statistics for assessing precarious employment in the region. The study allocates three blocks of indicators: indicators of institutional regulation, conditions of employment and functioning of the labor market. Based on these indicators, the author analyzes the status and trends of precarious work in the Vologda Oblast in the period from 2001 to 2015. In some cases, the author presents a comparative analysis of the data for the Russian Federation and Northwestern Federal District. The analysis has helped identify positive and negative changes in the field of precarious employment in the Vologda Oblast. In particular, the author identifies the following problems: an increase in the share of those employed in the informal sector, a relative increase in the number of the working poor, an almost three-fold growth of overdue debts on wages in comparable prices per worker. On the basis of this analysis, the author identifies the directions of the state policy that can help reduce precarious employment: development of information

  3. Grade 4 renal injury: current trend of management and

    Directory of Open Access Journals (Sweden)

    Ho Yiu Ming

    2011-04-01

    Full Text Available 【Abstract】The management of blunt renal trauma has been evolving. The past management largely based on American Association for Surgery of Trauma (AAST grading system, i.e. necessitated a computed tomography (CT scan. Although the CT scan use is increasing and becomes the standardized mode of investigation, AAST grading no longer plays the sole role in the decision of surgical interventions. Two case reports of blunt renal trauma managed successfully by conservative methods are presented. Case one was an 18 year-old boy who had a fall when riding a motorbike at 20 km/h with a helmet and full protective equipments. He was landed by his left flank onto a rock. Contrast abdominal CT revealed a 4 cm, grade III splenic tear and a grade IV left kidney injury with large perirenal haematoma. His international severity score (ISS was 34. He was managed conservatively with bed rest and frequent serum haemoglobin monitoring. Subsequent CT with delayed contrast revealed stable perirenal haematoma with urine extravasation which was consistent with a grade IV renal injury. Case two was a 40 year-old male who had a motor bike accident on a racetrack when he was driving at 80 to 100 km/h, wearing a helmet. He lost control and hit onto the sidewall of the racetrack. Contrast abdominal CT revealed a grade IV left renal injury with a large urine extravasation. His renal injury was managed conservatively with interval delayed phase CT of the abdomen. A repeat CT on abdomen was performed five months after the initial injury which revealed no residual urinoma. In this study, moreover, a review of the literature to the management of blunt renal trauma was conducted to demonstrate the trend of increasing conservative management of such traumas. Extra radiological parameters may guide future decision making. However, the applicability of data may be limited until randomized trials are available. Key words: Renal trauma; International classification of diseases

  4. Primary care in the Netherlands: current situation and trends

    Directory of Open Access Journals (Sweden)

    Dinny H. de Bakker

    2009-06-01

    Full Text Available

    Background: Primary care in the Netherlands has a strong international reputation. However, this picture may be qualified in two respects. First of all, the Dutch primary care system is less cohesive than is sometimes suggested. Secondly, there are major challenges in the Dutch system (as is the case with other European health care systems, which have to be resolved in order to maintain and improve primary care. Methods: Description of primary care in the Netherlands based on nationally and internationally published sources. Identification of challenges and trends. Narrative review of the literature.

    Results: GPs have a strong position in the Netherlands. Their numbers are relatively low; they have a gatekeeping position, and there is no cost-sharing for GP care (unlike other forms of care. The primary care system as a whole, however, is characterised by weak coherence. Individual primary care disciplines have their own separate modes of funding. Challenges include a growing and changing demand for primary care services, and changes in manpower and organisation, that affect the balance between demand and supply regarding primary care services.

    Conclusions: Among the threats to strong primary care are the risk of increasing fragmentation of care, negative side effects of a transformation process from cottage industry to service industry, and reluctance to invest in integrated primary care. An opportunity lies in the consensus among stakeholders that integrated primary care has a future. Technological developments support this, especially the development of electronic patient records.

  5. Persistent sodium current drives conditional pacemaking in CA1 pyramidal neurons under muscarinic stimulation.

    Science.gov (United States)

    Yamada-Hanff, Jason; Bean, Bruce P

    2013-09-18

    Hippocampal CA1 pyramidal neurons are normally quiescent but can fire spontaneously when stimulated by muscarinic agonists. In brain slice recordings from mouse CA1 pyramidal neurons, we examined the ionic basis of this activity using interleaved current-clamp and voltage-clamp experiments. Both in control and after muscarinic stimulation, the steady-state current-voltage curve was dominated by inward TTX-sensitive persistent sodium current (I(NaP)) that activated near -75 mV and increased steeply with depolarization. In control, total membrane current was net outward (hyperpolarizing) near -70 mV so that cells had a stable resting potential. Muscarinic stimulation activated a small nonselective cation current so that total membrane current near -70 mV shifted to become barely net inward (depolarizing). The small depolarization triggers regenerative activation of I(NaP), which then depolarizes the cell from -70 mV to spike threshold. We quantified the relative contributions of I(NaP), hyperpolarization-activated cation current (I(h)), and calcium current to pacemaking by using the cell's own firing as a voltage command along with specific blockers. TTX-sensitive sodium current was substantial throughout the entire interspike interval, increasing as the membrane potential approached threshold, while both Ih and calcium current were minimal. Thus, spontaneous activity is driven primarily by activation of I(NaP) in a positive feedback loop starting near -70 mV and providing increasing inward current to threshold. These results show that the pacemaking "engine" from I(NaP) is an inherent property of CA1 pyramidal neurons that can be engaged or disengaged by small shifts in net membrane current near -70 mV, as by muscarinic stimulation.

  6. The Future of School Social Work Practice: Current Trends and Opportunities

    OpenAIRE

    2005-01-01

    This article discusses the information on school social work practice in the United States and summarizes recent trends and their implications for the future of school social work. The number of school social workers and current infrastructure available for the development of school social work practice is reviewed. Five sociocultural trends are summarized that are affecting public schools as well as important school-based practice trends such as standardized testing, and high stakes accounta...

  7. Trends in the treatment changes and medication persistence of chronic myeloid leukemia in Taiwan from 1997 to 2007: a longitudinal population database analysis

    Directory of Open Access Journals (Sweden)

    Chang Chao-Sung

    2012-10-01

    Full Text Available Abstract Background Few studies have examined the longitudinal changes in the patterns, selection, and utilization of treatments for chronic myeloid leukemia (CML in routine clinical practice since the introduction of imatinib. Therefore, we investigated the trends in CML therapy, including changes, patterns, and persistence to imatinib therapy among patients with newly diagnosed CML. Methods We conducted a cross-sectional and longitudinal analysis of 11 years of claims data for patients with newly diagnosed CML included in the Taiwan National Health Insurance program. Pharmacy and diagnosis claims for newly diagnosed CML recorded between 1997 and 2007 year were extracted from the database. Annual overall use, new use of CML therapy, and persistence to imatinib therapy were estimated. The Anatomical Therapeutic Chemical codes for CML therapy [i.e., imatinib and conventional therapy: busulfan, hydroxyurea, interferon-α (IFNα, and cytarabine], and the process code for hematopoietic stem cell transplantation were used to categorize treatment patterns. Associations with patients characteristics were analyzed by multivariate logistic regression. Results Overall, the proportion of patients with newly diagnosed CML to all patients with CML increased by approximately 4-fold between 1998 and 2007. There were steady increases in the proportions of all treated patients and those starting therapy from 2003 to 2007. Fewer comorbid conditions and lower severity of CML were associated with treatment initiation. Medication persistence varied according to treatment duration, as 38.7% patients continued imatinib for ≥ 18 months without interruption but only 7.7% continued imatinib for ≥ 5 years. Factors associated with persistence to imatinib therapy were removal of the need for prior authorization for imatinib, and prior use of hydroxyurea and IFNα, whereas having undergone hematopoietic stem cell transplantation led to reduced likelihood

  8. Persistent Currents and Addition Spectrum in Strongly Interacting Chaotic Quantum Dots

    Science.gov (United States)

    Herman, Damir; Mathur, H.; Murthy, Ganpathy

    2003-03-01

    Murthy and Shankar(Ganpathy Murthy, R. Shankar, Quantum Dots with Disorder and Interactions: A Solvable Large-g Limit), family cond-mat/0209136 have introduced a non-perturbative approach to analyzing the effects of interaction and randomness in chaotic quantum dots in the limit of large Thouless number. Using this framework we study two experimentally observable quantities in the strongly interacting regime. First we compare the Coulomb blockade peak spacing distribution in the strong coupling regime to the distribution in the weak coupling regime (described by the ``universal Hamiltonian''). Second we study persistent currents in mesoscopic rings in the regime of strong interaction.

  9. Current trends in state child labor legislation and enforcement.

    Science.gov (United States)

    Beyer, D

    1993-09-01

    There is much current child labor law activity, none of it reflecting concern with occupational health hazards. The focus of the legislation is on time for and dedication to education as youth's foremost priority. The only areas of state legislative change that could affect children's health and safety in the workplace are a general movement toward monetarily increasing fines and penalties and some minor inclusions of agricultural restrictions on young workers. Enforcement efforts are in all cases a primary indication of state commitment to child labor law protections, and these efforts are decreasing.

  10. Current Trends on Lean Management – A review

    Directory of Open Access Journals (Sweden)

    M. Shabeena Begam

    2013-12-01

    Full Text Available All manufacturing industry has put in continuous efforts for its survival in the current impulsive and competitive economy. In order to handle the critical situation, manufacturers are trying to implement new and innovative techniques in their manufacturing process by making it more effective and efficient. A detailed literature survey has been conducted to identify the lean practices in various manufacturing industry. The results revealed that the status of Lean Manufacturing (LM implementation in still in thriving stage. This paper will further assist the organizations to improve its process, align it to the requirements of its customers and relentless contribution to manufacturing sector to enhance productivity, quality and competitiveness is immense.

  11. Computational chemistry reviews of current trends v.4

    CERN Document Server

    1999-01-01

    This volume presents a balanced blend of methodological and applied contributions. It supplements well the first three volumes of the series, revealing results of current research in computational chemistry. It also reviews the topographical features of several molecular scalar fields. A brief discussion of topographical concepts is followed by examples of their application to several branches of chemistry.The size of a basis set applied in a calculation determines the amount of computer resources necessary for a particular task. The details of a common strategy - the ab initio model potential

  12. Current Trends in Malaysian Higher Education and the Effect on Education Policy and Practice: An Overview

    Science.gov (United States)

    Grapragasem, Selvaraj; Krishnan, Anbalagan; Mansor, Azlin Norhaini

    2014-01-01

    Malaysia has evolved from a production-based to knowledge-based economy in order to stay relevant and compete in the global marketplace. Thus, the purpose of this article is to discuss current trends in Malaysian higher education and how these affect education policies and practices. Four main trends are discussed in this study: Globalization,…

  13. A Study of Current Trends and Issues Related to Technical/Engineering Design Graphics.

    Science.gov (United States)

    Clark, Aaron C.; Scales Alice

    2000-01-01

    Presents results from a survey of engineering design graphics educators who responded to questions related to current trends and issues in the profession of graphics education. Concludes that there is a clear trend in institutions towards the teaching of constraint-based modeling and computer-aided manufacturing. (Author/YDS)

  14. β-pompilidotoxin modulates spontaneous activity and persistent sodium currents in spinal networks.

    Science.gov (United States)

    Magloire, V; Czarnecki, A; Anwander, H; Streit, J

    2011-01-13

    The origin of rhythm generation in mammalian spinal cord networks is still poorly understood. In a previous study, we showed that spontaneous activity in spinal networks takes its origin in the properties of certain intrinsically spiking interneurons based on the persistent sodium current (INaP). We also showed that depolarization block caused by a fast inactivation of the transient sodium current (INaT) contributes to the generation of oscillatory activity in spinal cord cultures. Recently, a toxin called beta-pompilidotoxin (β-PMTX) that slows the inactivation process of tetrodotoxin (TTX)-sensitive sodium channels has been extracted from the solitary wasp venom. In the present study, we therefore investigated the effect of β-PMTX on rhythm generation and on sodium currents in spinal networks. Using intracellular recordings and multielectrode array (MEA) recordings in dissociated spinal cord cultures from embryonic (E14) rats, we found that β-PMTX reduces the number of population bursts and increases the background asynchronous activity. We then uncoupled the network by blocking all synaptic transmission (APV, CNQX, bicuculline and strychnine) and observed that β-PMTX increases both the intrinsic activity at individual channels and the number of intrinsically activated channels. At the cellular level, we found that β-PMTX has two effects: it switches 58% of the silent interneurons into spontaneously active interneurons and increases the firing rate of intrinsically spiking cells. Finally, we investigated the effect of β-PMTX on sodium currents. We found that this toxin not only affects the inactivation of INaT but also increases the peak amplitude of the persistent sodium current (INaP). Altogether, theses findings suggest that β-PMTX acting on INaP and INaT enhances intrinsic activity leading to a profound modulation of spontaneous rhythmic activity in spinal networks.

  15. Preparative Purification of Recombinant Proteins: Current Status and Future Trends

    Directory of Open Access Journals (Sweden)

    Mayank Saraswat

    2013-01-01

    Full Text Available Advances in fermentation technologies have resulted in the production of increased yields of proteins of economic, biopharmaceutical, and medicinal importance. Consequently, there is an absolute requirement for the development of rapid, cost-effective methodologies which facilitate the purification of such products in the absence of contaminants, such as superfluous proteins and endotoxins. Here, we provide a comprehensive overview of a selection of key purification methodologies currently being applied in both academic and industrial settings and discuss how innovative and effective protocols such as aqueous two-phase partitioning, membrane chromatography, and high-performance tangential flow filtration may be applied independently of or in conjunction with more traditional protocols for downstream processing applications.

  16. Current trends in medical image registration and fusion

    Directory of Open Access Journals (Sweden)

    Fatma El-Zahraa Ahmed El-Gamal

    2016-03-01

    Full Text Available Recently, medical image registration and fusion processes are considered as a valuable assistant for the medical experts. The role of these processes arises from their ability to help the experts in the diagnosis, following up the diseases’ evolution, and deciding the necessary therapies regarding the patient’s condition. Therefore, the aim of this paper is to focus on medical image registration as well as medical image fusion. In addition, the paper presents a description of the common diagnostic images along with the main characteristics of each of them. The paper also illustrates most well-known toolkits that have been developed to help the working with the registration and fusion processes. Finally, the paper presents the current challenges associated with working with medical image registration and fusion through illustrating the recent diseases/disorders that were addressed through such an analyzing process.

  17. Current Trends in Heparin Use During Arterial Vascular Interventional Radiology

    Energy Technology Data Exchange (ETDEWEB)

    Durran, Alexandra C., E-mail: durranjobs@hotmail.com [Peninsula Radiology Academy, Plymouth International Business Park (United Kingdom); Watts, Christopher, E-mail: Christopher.watts@salisbury.nhs.uk [Salisbury District Hospital (United Kingdom)

    2012-12-15

    Purpose: This study was designed to assess the current use of heparinized saline and bolus doses of heparin in non-neurological interventional radiology and to determine whether consensus could be reached to produce guidance for heparin use during arterial vascular intervention. Methods: An interactive electronic questionnaire was distributed to members of the British Society of Interventional Radiology regarding their current practice in the use, dosage, and timing of heparin boluses and heparinized flushing solutions.ResultsA total of 108 completed questionnaires were received. More than 80% of respondents used heparinized saline with varying concentrations; the most prevalent was 1,000 IU/l (international units of heparin per liter) and 5,000 IU/l. Fifty-one percent of interventionalists use 3,000 IU as their standard bolus dose; however, the respondents were split regarding the timing of bolus dose with {approx}60% administering it after arterial access is obtained and 40% after crossing the lesion. There was no consensus on altering dose according to body weight, and only 4% monitored clotting parameters. Conclusions: There seems to be some coherence among practicing interventionalists regarding heparin administration. We hypothesize that heparinized saline should be used at a recognized standard concentration of 1,000 IU/l as a flushing concentration in all arterial vascular interventions and that 3,000 IU bolus is considered the standard dose for straightforward therapeutic procedures and 5000 IU for complex, crural, and endovascular aneurysm repair work. The bolus should be given after arterial access is obtained to allow time for optimal anticoagulation to be achieved by the time of active intervention and stenting. Further research into clotting abnormalities following such interventional procedures would be an interesting quantifiable follow-up to this initial survey of opinions and practice.

  18. Computing at DESY — current setup, trends and strategic directions

    Science.gov (United States)

    Ernst, Michael

    1998-05-01

    Since the HERA experiments H1 and ZEUS started data taking in '92, the computing environment at DESY has changed dramatically. Running a mainframe centred computing for more than 20 years, DESY switched to a heterogeneous, fully distributed computing environment within only about two years in almost every corner where computing has its applications. The computing strategy was highly influenced by the needs of the user community. The collaborations are usually limited by current technology and their ever increasing demands is the driving force for central computing to always move close to the technology edge. While DESY's central computing has a multidecade experience in running Central Data Recording/Central Data Processing for HEP experiments, the most challenging task today is to provide for clear and homogeneous concepts in the desktop area. Given that lowest level commodity hardware draws more and more attention, combined with the financial constraints we are facing already today, we quickly need concepts for integrated support of a versatile device which has the potential to move into basically any computing area in HEP. Though commercial solutions, especially addressing the PC management/support issues, are expected to come to market in the next 2-3 years, we need to provide for suitable solutions now. Buying PC's at DESY currently at a rate of about 30/month will otherwise absorb any available manpower in central computing and still will leave hundreds of unhappy people alone. Though certainly not the only region, the desktop issue is one of the most important one where we need HEP-wide collaboration to a large extent, and right now. Taking into account that there is traditionally no room for R&D at DESY, collaboration, meaning sharing experience and development resources within the HEP community, is a predominant factor for us.

  19. Industrial Large Scale Applications of Superconductivity -- Current and Future Trends

    Science.gov (United States)

    Amm, Kathleen

    2011-03-01

    Since the initial development of NbTi and Nb3Sn superconducting wires in the early 1960's, superconductivity has developed a broad range of industrial applications in research, medicine and energy. Superconductivity has been used extensively in NMR low field and high field spectrometers and MRI systems, and has been demonstrated in many power applications, including power cables, transformers, fault current limiters, and motors and generators. To date, the most commercially successful application for superconductivity has been the high field magnets required for magnetic resonance imaging (MRI), with a global market well in excess of 4 billion excluding the service industry. The unique ability of superconductors to carry large currents with no losses enabled high field MRI and its unique clinical capabilities in imaging soft tissue. The rapid adoption of high field MRI with superconducting magnets was because superconductivity was a key enabler for high field magnets with their high field uniformity and image quality. With over 30 years of developing MRI systems and applications, MRI has become a robust clinical tool that is ever expanding into new and developing markets. Continued innovation in system design is continuing to address these market needs. One of the key questions that innovators in industrial superconducting magnet design must consider today is what application of superconductivity may lead to a market on the scale of MRI? What are the key considerations for where superconductivity can provide a unique solution as it did in the case of MRI? Many companies in the superconducting industry today are investigating possible technologies that may be the next large market like MRI.

  20. Sublingual administration of tacrolimus: current trends and available evidence.

    Science.gov (United States)

    Doligalski, Christina Teeter; Liu, Esther C; Sammons, Chelsea M; Silverman, Andrew; Logan, Angela Tong

    2014-11-01

    Widespread anecdotal use of sublingual tacrolimus administration has arisen, although little literature exists to guide practice. Given the paucity of data, we conducted a survey to evaluate the practice of sublingual tacrolimus administration at transplant centers across the United States and evaluated the literature that is currently available. A 10-question online survey assessing the current state of sublingual tacrolimus use was distributed to pharmacists at transplant centers that each performed more than 100 solid organ transplantations in 2013. In addition, a literature review was performed by searching the PubMed database to identify available evidence for the sublingual administration of tacrolimus. The online survey was completed by 59 (65.6%) of the 90 targeted transplant centers, representing 51.3% of all solid organ transplantations performed in 2013. Sublingual administration of tacrolimus was used in all solid organ transplant populations, with ~67% of lung transplant centers using this route for tacrolimus. The most common dose conversion was 2 mg oral to 1 mg sublingual, with 92% of centers opening oral capsules and administering the contents sublingually. Home use of sublingual administration and use in the pediatric population was uncommon. Seven peer-reviewed reports and one abstract were identified in the literature review. Seven of the eight publications reported favorably on sublingual administration, although no consistent dose conversion or method of administration was elucidated. The majority of the transplant centers surveyed found sublingual tacrolimus a viable alternative when oral administration is unavailable. A large robust prospective evaluation of sublingual administration of tacrolimus is imperative to provide the most effective care to solid organ transplant recipients and to ensure optimal safety for both patients and providers who administer the drug.

  1. Nationwide trends in the current management of desmoid (aggressive) fibromatosis.

    Science.gov (United States)

    Eastley, N C; Hennig, I M; Esler, C P; Ashford, R U

    2015-06-01

    The optimal management of desmoid fibromatosis remains unclear, leading to significant variability in patient management. To assess this problem, the current approach of clinicians managing this complex condition in the UK was investigated. A hypothetical case of intramuscular limb girdle desmoid fibromatosis in a fit 65-year-old patient was devised. Surgical and non-surgical oncology members of the British Sarcoma Group were questioned on how they would manage this case in three scenarios: primary disease with function-sparing surgery possible, primary disease with neurovascular involvement and disease recurrence after a previous R0 resection. Initial management, management of symptomatic disease progression, follow-up preferences and any differences in respondents' management choices in a younger case were investigated. The responses from 14 sarcoma surgeons and 23 oncologists (14 clinical, nine medical) were analysed. Desmoid fibromatosis management is generally shared by surgeons and oncologists within sarcoma multidisciplinary teams in the UK. Variation exists in the chosen initial management of primary desmoid fibromatosis in the UK, with function-sparing surgery possible (observation 51%, resection 51%), primary desmoid fibromatosis with neurovascular involvement (hormone therapy with non-steroidal anti-inflammatory drugs 51%, radiotherapy 27%, observation 22%) and for cases of desmoid fibromatosis recurrence (radiotherapy 41%, hormone therapy and non-steroidal anti-inflammatory drugs 27%, observation 24%). There was a clear preference of surgical resection of symptomatic disease progression in cases of primary desmoid fibromatosis without neurovascular involvement (60%). By contrast, radiotherapy was the preferred treatment for progression in cases with neurovascular involvement (47%) or cases of recurrence after a previous R0 resection (34%). Clinical follow-up was selected 3 months after intervention in 68% of scenarios. Follow-up imaging was selected 3

  2. Current Trends and Challenges in Satellite Laser Ranging

    Science.gov (United States)

    Appleby, Graham M.; Bianco, Giuseppe; Noll, Carey E.; Pavlis, Erricos C.; Pearlman, Michael R.

    2016-12-01

    Satellite Laser Ranging (SLR) is used to measure accurately the distance from ground stations to retro-reflectors on satellites and on the Moon. SLR is one of the fundamental space-geodetic techniques that define the International Terrestrial Reference Frame (ITRF), which is the basis upon which many aspects of global change over space, time, and evolving technology are measured; with VLBI the two techniques define the scale of the ITRF; alone the SLR technique defines its origin (geocenter). The importance of the reference frame has recently been recognized at the inter-governmental level through the United Nations, which adopted in February 2015 the Resolution "Global Geodetic Reference Frame for Sustainable Development." Laser Ranging provides precision orbit determination and instrument calibration and validation for satellite-borne altimeters for the better understanding of sea level change, ocean dynamics, ice mass-balance, and terrestrial topography. It is also a tool to study the dynamics of the Moon and fundamental constants and theories. With the exception of the currently in-orbit GPS constellation, all GNSS satellites now carry retro-reflectors for improved orbit determination, harmonization of reference frames, and in-orbit co-location and system performance validation; the next generation of GPS satellites due for launch from 2019 onwards will also carry retro-reflectors. The ILRS delivers weekly realizations that are accumulated sequentially to extend the ITRF and the Earth Orientation Parameter series with a daily resolution. SLR technology continues to evolve towards the next-generation laser ranging systems and it is expected to successfully meet the challenges of the GGOS2020 program for a future Global Space Geodetic Network. Ranging precision is improving as higher repetition rate, narrower pulse lasers, and faster detectors are implemented within the network. Automation and pass interleaving at some stations is expanding temporal coverage and

  3. Labour Markets Trends, Financial Globalization and the current crisis in Developing Countries

    NARCIS (Netherlands)

    R.E. van der Hoeven (Rolph)

    2010-01-01

    textabstractThe current wave of globalization has profound labour market effects, accentuated, in many cases, by the current financial and economic crisis. This paper reviews general labour market trends and country examples, arguing that the current globalization process makes labour’s position mor

  4. Labour Markets Trends, Financial Globalization and the current crisis in Developing Countries

    NARCIS (Netherlands)

    R.E. van der Hoeven (Rolph)

    2010-01-01

    textabstractThe current wave of globalization has profound labour market effects, accentuated, in many cases, by the current financial and economic crisis. This paper reviews general labour market trends and country examples, arguing that the current globalization process makes labour’s position

  5. Current trends in small vocabulary speech recognition for equipment control

    Science.gov (United States)

    Doukas, Nikolaos; Bardis, Nikolaos G.

    2017-09-01

    Speech recognition systems allow human - machine communication to acquire an intuitive nature that approaches the simplicity of inter - human communication. Small vocabulary speech recognition is a subset of the overall speech recognition problem, where only a small number of words need to be recognized. Speaker independent small vocabulary recognition can find significant applications in field equipment used by military personnel. Such equipment may typically be controlled by a small number of commands that need to be given quickly and accurately, under conditions where delicate manual operations are difficult to achieve. This type of application could hence significantly benefit by the use of robust voice operated control components, as they would facilitate the interaction with their users and render it much more reliable in times of crisis. This paper presents current challenges involved in attaining efficient and robust small vocabulary speech recognition. These challenges concern feature selection, classification techniques, speaker diversity and noise effects. A state machine approach is presented that facilitates the voice guidance of different equipment in a variety of situations.

  6. Vestibular compensation and vestibular rehabilitation. Current concepts and new trends.

    Science.gov (United States)

    Deveze, A; Bernard-Demanze, L; Xavier, F; Lavieille, J-P; Elziere, M

    2014-01-01

    The aim of this review is to present the current knowledge of the mechanisms underlying the vestibular compensation and demonstrating how the vestibular rehabilitation is conducted to help the recovery of balance function. Vestibular rehabilitation is based on improving the natural phenomenon called vestibular compensation that occurs after acute vestibular disturbance or chronic and gradual misbalance. Central compensation implies three main mechanisms namely adaptation, substitution and habituation. The compensation, aided by the rehabilitation aimed to compensate and/or to correct the underused or misused of the visual, proprioceptive and vestibular inputs involved in the postural control. As the strategy of equilibration is not corrected, the patient is incompletely cured and remains with inappropriate balance control with its significance on the risk of fall and impact on quality of life. The vestibular rehabilitation helps to correct inappropriate strategy of equilibrium or to accelerate a good but slow compensation phenomenon. Nowadays, new tools are more and more employed for the diagnosis of vestibular deficit (that may include various sources of impairment), the assessment of postural deficit, the control of the appropriate strategy as well to facilitate the efficiency of the rehabilitation especially in elderly people.

  7. P300 brain computer interface: current challenges and emerging trends

    Directory of Open Access Journals (Sweden)

    Reza eFazel-Rezai

    2012-07-01

    Full Text Available A brain-computer interface (BCI enables communication without movement based on brain signals measured with electroencephalography (EEG. BCIs usually rely on one of three types of signals: the P300 and other components of the event-related potential (ERP, steady state visual evoked potential (SSVEP, or event related desynchronization (ERD. Although P300 BCIs were introduced over twenty years ago, the past few years have seen a strong increase in P300 BCI research. This closed-loop BCI approach relies on the P300 and other components of the event-related potential (ERP, based on an oddball paradigm presented to the subject. In this paper, we overview the current status of P300 BCI technology, and then discuss new directions: paradigms for eliciting P300s; signal processing methods; applications; and hybrid BCIs. We conclude that P300 BCIs are quite promising, as several emerging directions have not yet been fully explored and could lead to improvements in bit rate, reliability, usability, and flexibility.

  8. Current trends in the diagnosis and treatment of tuboovarian abscess

    Energy Technology Data Exchange (ETDEWEB)

    Landers, D.V.; Sweet, R.L.

    1985-04-15

    Tuboovarian abscess is a well-recognized complication of acute salpingitis and has been reported in as many as one third of hospital admissions for acute salpingitis. The incidence of tuboovarian abscess is expected to increase as a result of the current epidemic of sexually transmitted diseases and their sequelae. Patients with tuboovarian abscess most commonly present with lower abdominal pain and an adnexal mass(es). Fever and leukocytosis may be absent. Ultrasound, computed tomographic scans, laparoscopy, or laparotomy may be necessary to confirm the diagnosis. Tuboovarian abscess may be unilateral or bilateral regardless of intrauterine contraceptive device usage. Tuboovarian abscess is polymicrobial with a preponderance of anaerobic organisms. An initial conservative antimicrobial approach to the management of the unruptured tuboovarian abscess is appropriate if the antimicrobial agents used can penetrate abscesses, remain active within the abscess environment, and are active against the major pathogens in tuboovarian abscess, including the resistant gram-negative anaerobes such as Bacteroides fragilis and Bacteroides bivius. However, if the patient does not begin to show a response within a reasonable amount of time, about 48 to 72 hours, surgical intervention should be undertaken. Suspicion of rupture should remain an indication for immediate operation. Once operation is undertaken, a conservative approach with unilateral adnexectomy for one-side tuboovarian abscess is appropriate if future fertility or hormone production is desired.

  9. Helicobacter pylori eradication therapy: A review of current trends.

    Science.gov (United States)

    Olokoba, A B; Obateru, O A; Bojuwoye, M O

    2013-01-01

    Helicobacter pylori has been implicated in the formation of chronic gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. Eradication of H. Pylori has been recommended as treatment and prevention for these complications. This review is based on a search of Medline, the Cochrane Database of Systemic Reviews, and citation lists of relevant publications. Subject heading and key words used include H. Pylori, current treatment and emerging therapy. Only articles in English were included. There has been a substantial decline in the H. pylori eradication rates over the years, despite the use of proton pump inhibitor and bismuth salts for triple and quadruple therapies respectively. The reasons for eradication failure are diverse, among them, antibiotic resistance is an important factor in the treatment failure. Primary resistance to clarithromycin or metronidazole significantly affects the efficacy of eradication therapy. This has led to the introduction of second line, third line "rescue," and sequential therapies for resistant cases. Subsequently, new antibiotic combinations with proton-pump inhibitors and bismuth salts are being studied in the last decade, to find out the antibiotics that are capable of increasing the eradication rates. Some of these antibiotics include Levofloxacin, Doxycycline, Rifaximin, Rifampicin, Furazolidone based therapies. Studies are ongoing to determine the efficacy of Lactoferrin based therapy.

  10. Helicobacter pylori eradication therapy: A review of current trends

    Directory of Open Access Journals (Sweden)

    A B Olokoba

    2013-01-01

    Full Text Available Helicobacter pylori has been implicated in the formation of chronic gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. Eradication of H. Pylori has been recommended as treatment and prevention for these complications. This review is based on a search of Medline, the Cochrane Database of Systemic Reviews, and citation lists of relevant publications. Subject heading and key words used include H. Pylori, current treatment and emerging therapy. Only articles in English were included. There has been a substantial decline in the H. pylori eradication rates over the years, despite the use of proton pump inhibitor and bismuth salts for triple and quadruple therapies respectively. The reasons for eradication failure are diverse, among them, antibiotic resistance is an important factor in the treatment failure. Primary resistance to clarithromycin or metronidazole significantly affects the efficacy of eradication therapy. This has led to the introduction of second line, third line "rescue," and sequential therapies for resistant cases. Subsequently, new antibiotic combinations with proton-pump inhibitors and bismuth salts are being studied in the last decade, to find out the antibiotics that are capable of increasing the eradication rates. Some of these antibiotics include Levofloxacin, Doxycycline, Rifaximin, Rifampicin, Furazolidone based therapies. Studies are ongoing to determine the efficacy of Lactoferrin based therapy.

  11. Preemptive analgesia II: recent advances and current trends.

    LENUS (Irish Health Repository)

    Kelly, D J

    2012-02-03

    PURPOSE: This two-part review summarizes the current knowledge of physiological mechanisms, pharmacological modalities and controversial issues surrounding preemptive analgesia. SOURCE: Articles from 1966 to present were obtained from the MEDLINE databases. Search terms included analgesia, preemptive; neurotransmitters; pain, postoperative; hyperalgesia; sensitization, central nervous system; pathways, nociception; anesthetic techniques; analgesics, agents. Principal findings: In Part I of this review article, techniques and agents that attenuate or prevent central and peripheral sensitization were reviewed. In Part II, the conditions required for effective preemptive techniques are evaluated. Specifically, preemptive analgesia may be defined as an antinociceptive treatment that prevents establishment of altered central processing of afferent input from sites of injury. The most important conditions for establishment of effective preemptive analgesia are the establishment of an effective level of antinociception before injury, and the continuation of this effective analgesic level well into the post-injury period to prevent central sensitization during the inflammatory phase. Although single-agent therapy may attenuate the central nociceptive processing, multi-modal therapy is more effective, and may be associated with fewer side effects compared with the high-dose, single-agent therapy. CONCLUSION: The variable patient characteristics and timing of preemptive analgesia in relation to surgical noxious input require individualization of the technique(s) chosen. Multi-modal analgesic techniques appear more effective.

  12. Current Approaches and Future Trends to Promote Tendon Repair.

    Science.gov (United States)

    Morais, D S; Torres, J; Guedes, R M; Lopes, M A

    2015-09-01

    Tendons are composed by extracellular collagen fibres arranged in regular arrays and are responsible to transmit tensile forces from a muscle to a bone. Due to their poor healing ability, in some cases tendons injuries are debilitating impairments that affect life quality among adult population worldwide. In the last years, attending to the social and economic concern associated to the high prevalence of tendons injuries and the limited success of the available current treatments, several scaffolds have been developed. Some of these scaffolds are intended to be used as graft-augmentation devices and others to fully replace a damaged tendon. The synthetic ones present superior mechanical characteristics compared to biological scaffolds. However, attending to the specific tendons physiology, even the synthetic scaffolds still don´t present the ideal mechanical properties to accomplish a complete and long-term functional tissue repair. Therefore, to enhance tendogenesis when using a tendon engineering approach, several methodologies have been developed to associate with scaffolds, including surface modification and cell seeding.

  13. Current Trends in the Transhumant Cattle Sector in Greece

    Directory of Open Access Journals (Sweden)

    Athanasios Ragkos

    2013-05-01

    Full Text Available Bovine transhumance is characterized by the seasonal movement of livestock between winter and summer pastures. The system is well-known for Mediterranean countries, including Greece, where its role is multifunctional, because of its complex interactions with the environments and local societies. Unlike the dairy farming sector in Greece, whose salient features are the emergence of large-sized farms which are heavily dependent on fixed capital endowments and the provision of feedstuff, the transhumant system is much more flexible, by taking advantage of excessive family labor and by reducing feeding costs through grazing. The total number of transhumant farms in Greece has diminished during the last decades this farming system remains an essential activity in less favored areas of the country; the bovine cattle transhumant system, in particular, provides an efficient alternative to the capital-intensive dairy farming system. The purpose of this study is to provide a presentation of the current condition of the transhumant bovine cattle farming system in Greece. Through a survey of all relevant public services, data concerning the number of transhumant farms and animals as well as their movements in 2011 are presented. The survey reveals that the larger amount of transhumant farms is present in the lowlands of Thessaly and of East Macedonia-Thrace and move towards the mountainous rangelands of less favored areas, particularly those of West Macedonia. The mean transhumant bovine farm size does not exceed 100 animals, as nearly 76.1%, of the total rear less than 100 cattle. Thessaly is the region which accommodates the major part of transhumant farming in Greece; this is also the case for transhumant cattle, as 51.4% of all transhumant farms in the country have their winter domiciles in Thessaly.

  14. Adjuvants to local anesthetics: Current understanding and future trends

    Science.gov (United States)

    Swain, Amlan; Nag, Deb Sanjay; Sahu, Seelora; Samaddar, Devi Prasad

    2017-01-01

    Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of local anaesthetics. The armamentarium of local anesthetic adjuvants have evolved over time from classical opioids to a wide array of drugs spanning several groups and varying mechanisms of action. A large array of opioids ranging from morphine, fentanyl and sufentanyl to hydromorphone, buprenorphine and tramadol has been used with varying success. However, their use has been limited by their adverse effect like respiratory depression, nausea, vomiting and pruritus, especially with its neuraxial use. Epinephrine potentiates the local anesthetics by its antinociceptive properties mediated by alpha-2 adrenoreceptor activation along with its vasoconstrictive properties limiting the systemic absorption of local anesthetics. Alpha 2 adrenoreceptor antagonists like clonidine and dexmedetomidine are one of the most widely used class of local anesthetic adjuvants. Other drugs like steroids (dexamethasone), anti-inflammatory agents (parecoxib and lornoxicam), midazolam, ketamine, magnesium sulfate and neostigmine have also been used with mixed success. The concern regarding the safety profile of these adjuvants is due to its potential neurotoxicity and neurological complications which necessitate further research in this direction. Current research is directed towards a search for agents and techniques which would prolong local anaesthetic action without its deleterious effects. This includes novel approaches like use of charged molecules to produce local anaesthetic action (tonicaine and n butyl tetracaine), new age delivery mechanisms for prolonged bioavailability (liposomal

  15. Current trends of sugar consumption in developing societies.

    Science.gov (United States)

    Ismail, A I; Tanzer, J M; Dingle, J L

    1997-12-01

    This paper reviews recent data on sugar consumption in developing countries that may lead to a potential increase in caries prevalence. A search of the business, dental and nutritional literature was conducted through May 1995. There is evidence that sugar (sucrose) use was increasing in China, India, and Southeast Asia. In South and Central America (except Haiti) sugar use was either equivalent to or higher than that in most developed societies. In the Middle East, average sugar use was higher than that of other developing areas. However, it was either lower than or equivalent to the levels reported by other developed countries. Many central African countries consumed less than 15 kg of sugar/ person/year. Of particular concern is a rise in the consumption of sugar-containing carbonated beverages in a number of developing societies: China, India, Vietnam, Thailand, and other Southeast Asian countries are currently major growth markets for the soft drink industry. Consumption of high-sugar desserts and snacks may also be increasing in urban centers in some developing countries. To counteract the potential increase in the prevalence of dental caries in some developing countries, preventive and oral health promotion programs should be planned and implemented. We contend that taxation of sugar-containing products as well as efforts to reduce the level of sugar consumption to "safe" levels may be impractical, and in most countries, cannot be supported for political, economic, or health reasons. Instead, we recommend that collaboration be established between public health authorities and manufacturers/distributors of soft drinks and sweets in developing countries to establish a dental health fund that could be used to support caries preventive programs. The fund could be supported through donations from manufacturers based on the principle of the "milli-cent" (1 cent for every 1000 cents of sales). This minimal contribution would provide enough financial support for

  16. Global Trends and Current Status of Commercial Urban Rooftop Farming

    Directory of Open Access Journals (Sweden)

    Devi Buehler

    2016-10-01

    Full Text Available The aim of this study was to analyze current practices in commercial urban rooftop farming (URF. In recent years, URF has been experiencing increasing popularity. It is a practice that is well-suited to enhancing food security in cities and reducing the environmental impact that results from long transportation distances that are common in conventional agriculture. To date, most URF initiatives have been motivated by social and educational factors rather than the aim of creating large sustainable food production systems in cities. The commercial operation of urban rooftop farms, should they become profitable, is likely to attract notable private investment, allowing a significant level of high quality urban food production to be achieved. There is a reasonable amount of literature available on urban farming that deals with its potential, and its limitations. However, it does not focus on commercial operations. In contrast to other surveys and theoretical papers, this study of URF focuses on large and commercial operations. The analysis showed that commercial URFs can be grouped into two main types: Firstly, hydroponic systems in greenhouses where mostly leafy greens, tomatoes, and herbs are grown; secondly, soil-based open-air farms that grow a large variety of vegetables. Hydroponics is frequently seen as the key technology for commercial urban food production. While the technology is not in and of itself sustainable, hydroponic farms often make an effort to implement environmentally friendly technologies and methods. However, there is still untapped potential to systemically integrate farms into buildings. The findings of this study identified where future research is needed in order to make URF a widespread sustainable solution.

  17. Systemic Immunotherapy for Urothelial Cancer: Current Trends and Future Directions.

    Science.gov (United States)

    Gupta, Shilpa; Gill, David; Poole, Austin; Agarwal, Neeraj

    2017-01-27

    Urothelial cancer of the bladder, renal pelvis, ureter, and other urinary organs is the fifth most common cancer in the United States, and systemic platinum-based chemotherapy remains the standard of care for first-line treatment of advanced/metastatic urothelial carcinoma (UC). Until recently, there were very limited options for patients who are refractory to chemotherapy, or do not tolerate chemotherapy due to toxicities and overall outcomes have remained very poor. While the role of immunotherapy was first established in non-muscle invasive bladder cancer in the 1970s, no systemic immunotherapy was approved for advanced disease until the recent approval of a programmed death ligand-1 (PD-L1) inhibitor, atezolizumab, in patients with advanced/metastatic UC who have progressed on platinum-containing regimens. This represents a significant milestone in this disease after a void of over 30 years. In addition to atezolizumab, a variety of checkpoint inhibitors have shown a significant activity in advanced/metastatic urothelial carcinoma and are expected to gain Food and Drug Administration (FDA) approval in the near future. The introduction of novel immunotherapy agents has led to rapid changes in the field of urothelial carcinoma. Numerous checkpoint inhibitors are being tested alone or in combination in the first and subsequent-line therapies of metastatic disease, as well as neoadjuvant and adjuvant settings. They are also being studied in combination with radiation therapy and for non-muscle invasive bladder cancer refractory to BCG. Furthermore, immunotherapy is being utilized for those ineligible for firstline platinum-based chemotherapy. This review outlines the novel immunotherapy agents which have either been approved, or are currently being investigated in clinical trials in UC.

  18. Systemic Immunotherapy for Urothelial Cancer: Current Trends and Future Directions

    Directory of Open Access Journals (Sweden)

    Shilpa Gupta

    2017-01-01

    Full Text Available Urothelial cancer of the bladder, renal pelvis, ureter, and other urinary organs is the fifth most common cancer in the United States, and systemic platinum-based chemotherapy remains the standard of care for first-line treatment of advanced/metastatic urothelial carcinoma (UC. Until recently, there were very limited options for patients who are refractory to chemotherapy, or do not tolerate chemotherapy due to toxicities and overall outcomes have remained very poor. While the role of immunotherapy was first established in non-muscle invasive bladder cancer in the 1970s, no systemic immunotherapy was approved for advanced disease until the recent approval of a programmed death ligand-1 (PD-L1 inhibitor, atezolizumab, in patients with advanced/metastatic UC who have progressed on platinum-containing regimens. This represents a significant milestone in this disease after a void of over 30 years. In addition to atezolizumab, a variety of checkpoint inhibitors have shown a significant activity in advanced/metastatic urothelial carcinoma and are expected to gain Food and Drug Administration (FDA approval in the near future. The introduction of novel immunotherapy agents has led to rapid changes in the field of urothelial carcinoma. Numerous checkpoint inhibitors are being tested alone or in combination in the first and subsequent-line therapies of metastatic disease, as well as neoadjuvant and adjuvant settings. They are also being studied in combination with radiation therapy and for non-muscle invasive bladder cancer refractory to BCG. Furthermore, immunotherapy is being utilized for those ineligible for firstline platinum-based chemotherapy. This review outlines the novel immunotherapy agents which have either been approved, or are currently being investigated in clinical trials in UC.

  19. Oxytocin and Socioemotional Aging─Current Knowledge and Future Trends

    Directory of Open Access Journals (Sweden)

    Natalie C. Ebner

    2013-08-01

    Full Text Available The oxytocin (OT system is involved in various aspects of social cognition and prosocial behavior. Specifically, OT has been examined in the context of social memory, emotion recognition, cooperation, trust, empathy, and bonding, and─though evidence is somewhat mixed─intranasal OT appears to benefit aspects of socioemotional functioning. However, most of the extant data on aging and OT is from animal research and human OT research has focused largely on young adults. As such, though we know that various socioemotional capacities change with age, we know little about whether age-related changes in the OT system may underlie age-related differences in socioemotional functioning. In this review, we take a genetic-neuro-behavioral approach and evaluate current evidence on age-related changes in the OT system as well as the putative effects of these alterations on age-related socioemotional functioning. Looking forward, we identify informational gaps and propose an Age-Related Genetic, Neurobiological, Sociobehavioral Model of Oxytocin (AGeNeS-OT model which may structure and inform investigations into aging-related genetic, neural, and sociocognitive processes related to OT. As an exemplar of the use of the model, we report exploratory data suggesting differences in socioemotional processing associated with genetic variation in the oxytocin receptor gene (OXTR in samples of young and older adults. Information gained from this arena has translational potential in depression, social stress, and anxiety─all of which have high relevance in aging─and may contribute to reducing social isolation and improving well-being of individuals across the lifespan.

  20. Characteristics of persistent-current mode of HTS coil on superconducting electromagnet

    Energy Technology Data Exchange (ETDEWEB)

    Lee, C.Y., E-mail: cylee@krri.re.kr [Korea Railroad Research Institute, Woram Dong, Uiwang Si 437-757 (Korea, Republic of); Kim, J.; Han, Y.J.; Kang, B. [Korea Railroad Research Institute, Woram Dong, Uiwang Si 437-757 (Korea, Republic of); Chung, Y.D. [Department of Electrical Engineering, Suwon University, Bongdang Eup, Hwaseong Si 445-743 (Korea, Republic of); Yoon, Y.S. [Department of Electrical Engineering, Ansan College of Technology, Choji-Dong, Ansan Si 425-792 (Korea, Republic of); Chu, S.Y.; Hwang, Y.J.; Jo, H.C.; Jang, J.Y.; Ko, T.K. [Department of Electrical and Electronic Engineering, Yonsei University, Sinchon-dong, Seoul 120-749 (Korea, Republic of)

    2011-11-15

    The levitation gap of an electromagnetic suspension (EMS) system affects the current decay rate of superconducting electromagnet. The presence of iron core provides a significant benefit in the PCM performance of SC coil. The increased levitation gap of the EMS model with the SC-EM could negatively affect the design of SC-EM operated in PCM. This paper investigates the way in which the levitation gap of an electromagnetic suspension (EMS) system affects the current decay rate of superconducting electromagnet (SC-EM) operated in persistence-current mode (PCM). Using inductance analyzed from the magnetic circuit of an EMS model, the current decay rate caused by the variation in the levitation gap was simulated. In order to experimentally verify the simulation results, we fabricated a small-scale EMS model with SC coil operated in PCM and measured the current decay rates at different levitation gaps. The result showed that the presence of iron core provides a significant benefit in the PCM performance of SC coil, but the benefit decreased as the levitation gap increases. This study revealed that the increased levitation gap of the EMS model with the SC-EM could negatively affect the design of SC-EM operated in PCM.

  1. A Negative Slope Conductance of the Persistent Sodium Current Prolongs Subthreshold Depolarizations.

    Science.gov (United States)

    Ceballos, Cesar C; Roque, Antonio C; Leão, Ricardo M

    2017-07-18

    Neuronal subthreshold voltage-dependent currents determine membrane properties such as the input resistance (Rin) and the membrane time constant (τm) in the subthreshold range. In contrast with classical cable theory predictions, the persistent sodium current (INaP), a non-inactivating mode of the voltage-dependent sodium current, paradoxically increases Rin and τm when activated. Furthermore, this current amplifies and prolongs synaptic currents in the subthreshold range. Here, using a computational neuronal model, we showed that the creation of a region of negative slope conductance by INaP activation is responsible for these effects and the ability of the negative slope conductance to amplify and prolong Rin and τm relies on the fast activation of INaP. Using dynamic clamp in hippocampal CA1 pyramidal neurons in brain slices, we showed that the effects of INaP on Rin and τm can be recovered by applying an artificial INaP after blocking endogenous INaP with tetrodotoxin. Furthermore, we showed that injection of a pure negative conductance is enough to reproduce the effects of INaP on Rin and τm and is also able to prolong artificial excitatory post synaptic currents. Since both the negative slope conductance and the almost instantaneous activation are critical for producing these effects, the INaP is an ideal current for boosting the amplitude and duration of excitatory post synaptic currents near the action potential threshold. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  2. Current research trends in mountain biodiversity in NW Europe

    Directory of Open Access Journals (Sweden)

    Väisänen, Risto A.

    1998-12-01

    Full Text Available Focusing on four themes in relation to biodiversity (vegetation science, keystone grazers, long-term studies and protected areas, a synthesis of current research in the mountain areas of Fennoscandia, Iceland and Scotland is presented. Recent relevant advances in vegetation science include classifications of mountain habitats which together with species distribution maps offer new possibilities for analysis. Generalisations emerging from comparisons of the ecology and ecophysiology of plants between different mountain areas are greatly needed. Further studies on the ecological impacts of keystone grazers are urgently required because of the alarming rate of degradation of mountain habitats. The topics highlighted from northern Fennoscandia include (i the effect of overgrazing by reindeer on the cover of foliose lichens and on the regeneration of mountain birch, (ii the ecological interactions between the autumnal moth and mountain birch, and (Hi the effect of rodents on vegetation. Long-term studies of slow processes to capture rare but important events are needed to better understand the functioning of mountain ecosystems. Examples of such studies are presented for (i the moss Racomitrium lanuginosum as an indicator of airborne nitrogen pollution, (ii research based on cyclic oscillations of vole numbers, and (Hi the application of breeding birds in environmental assessment. The conservation of appropriate areas is important for mountain biodiversity. Mountain habitats have been protected extensively in northern Europe. The evaluation of how representative the existing areas are and how to use them for research need international co-ordination.

    [fr] On présente une synthèse de la recherche actuelle dans les régions de montagne de la Scandinavie, l'Islande et l'Ecosse, centrée sur quatre sujets autour de la biodiversité (science de la végétation, herbivores principaux, études à long terme et zones protégées. Les r

  3. Persistent current and Drude weight of one-dimensional interacting fermions on imperfect ring from current lattice density functional theory

    Science.gov (United States)

    Akande, Akinlolu; Sanvito, Stefano

    2016-11-01

    We perform a numerical study of interacting one-dimensional Hubbard rings with a single impurity potential and pierced by a magnetic flux. Our calculations are carried out at the level of current lattice density functional theory (CLDFT) for the Hubbard model and compared to known results obtained in the thermodynamical limit from the Bethe ansatz. In particular, we investigate the effects of disorder and Coulomb interaction on the persistent current (PC) and the Drude weight. It is found that CLDFT is able to accurately describe qualitative and quantitative features of these ground state properties in the presence of disorder and electronic interaction. When the impurity potential is switched off, the CLDFT approach describes well the velocity of the Luttinger liquid excitations as a function of both interaction strength and electron filling. Then, when the impurity scattering potential is finite, we find the PC to vanish as {{L}-{{α\\text{B}}-1}} for large L and independent on the strength of the scattering potential, in good agreement with Luttinger liquid theory.

  4. Persisting malnutrition in Chandigarh: decadal underweight trends and impact of ICDS program.

    Science.gov (United States)

    Thakur, Jarnail Singh; Prinja, Shankar; Bhatia, Satpal Singh

    2011-04-01

    Decline in malnutrition levels has been dismal since the 1990s. We ascertained decadal trend in childhood nutritional status between 1997 and 2007 in Chandigarh, India and assessed impact of Integrated Child Development Services (ICDS) on childhood undernutrition. A total of 803 under-five children, 547 children between 12-23 months age, and 218 women with an infant child were recruited for the study. Findings of present study were compared with another methodologically similar study (1997) from Chandigarh and Reproductive and Child Health Rapid Household Survey (1998) to draw decadal trends. Prevalence of underweight among under-five children remained almost stagnant in the last one decade from 51.6%; (1997) to 50.4%; (2007). There was insignificant difference (P=0.3) in prevalence of underweight among children registered under ICDS program (52.1%;) and those not registered (48.4%;) in 2007. Other health and service provision indicators had mixed results in the past decade. Health services utilization was poorest in urban slums.

  5. Race-specific trends in HPV vaccinations and provider recommendations: persistent disparities or social progress?

    Science.gov (United States)

    Burdette, Amy M; Webb, Noah S; Hill, Terrence D; Jokinen-Gordon, Hanna

    2017-01-01

    Although racial and ethnic differences in HPV vaccination initiation are well established, it is unclear whether these disparities have changed over time. The role of health provider recommendations in reducing any racial and ethnic inequalities is also uncertain. This study addresses these gaps in the literature. Repeated cross-sectional design. Using data from the National Immunization Survey-Teen (2008-2013), we estimated a series of binary logistic regressions to model race-specific trends in (1) provider recommendations to vaccinate against HPV and (2) HPV vaccine initiation for males (n = 56,632) and females (n = 77,389). Provider recommendations to vaccinate and HPV vaccination uptake have increased over time for adolescent males and females and across all racial and ethnic groups. Among girls, minority youths have seen a sharper increase in provider recommendations and HPV vaccination uptake than their White counterparts. Among boys, minority teens maintain higher overall rates of HPV vaccine uptake, however, Hispanics have lagged behind non-Hispanic Whites in the rate of increase in provider recommendations and HPV vaccinations. Our results suggest that racial and ethnic disparities in provider recommendations and HPV vaccinations have waned over time among males and females. While these trends are welcomed, additional interventions are warranted to increase overall rates of vaccination across race, ethnicity, and gender. Copyright © 2016 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  6. Persistent organochlorines in beluga whales (Delphinapterus leucas) from the St Lawrence River estuary--II. Temporal trends, 1982-1994.

    Science.gov (United States)

    Muir, D C; Koczanski, K; Rosenberg, B; Béland, P

    1996-01-01

    Blubber samples from 16 dead beluga whales (Delphinapterus leucas) collected during 1993-1994 in the St Lawrence River estuary were analysed for PCB congeners and other persistent organochlorines (DDT-group, chlorinated bornanes (toxaphene, CHB), chlordane SigmaCHL), hexachloro-cyclohexanes (SigmaHCH), chlorobenzenes (SigmaCBz), tris(p-chlorophenyl methane (TPMe) and mirex). Concentrations and relative proportions of major individual organochlorine components were within the same range as previous results for this population. Temporal trends were studied by combining the results with data from the analysis of 44 samples (1986-1990) and (for DDT and Aroclor PCBs only) with 20 samples (1982-1985) reported by Martineau et al., 1987. Results were lipid normalized and then age-adjusted by an ANCOVA model. Significant relationships between age and concentrations of most organochlorine groups were found for females but not for males. Significant declines were observed in SigmaDDT, and Aroclor PCBs (1.5- and 1.9-fold, respectively) in males between the 1982-1985 and 1993-1994 collection periods. Significant declines were also observed for SigmaHCH and SigmaCBz in males between 1986-1988 and 1993-1994. Mean concentrations of CHBs were significantly higher in 1993-1994 than in earlier years while dieldrin, SigmaCHL, mirex, and TPMe showed no trend. Declines in concentrations of major organochlorine groups were not observed in females possibly because of higher year to year, and within year, variation. The temporal trend in DDT and PCB concentrations in male beluga blubber paralleled trends in seals, eels, and seabirds in the St Lawrence estuary observed during the 1980s.

  7. Temporal trends (1987-2002) of persistent, bioaccumulative and toxic (PBT) chemicals in beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary, Canada.

    Science.gov (United States)

    Lebeuf, Michel; Noël, Michelle; Trottier, Steve; Measures, Lena

    2007-09-20

    Temporal trends of persistent, bioaccumulative and toxic (PBT) chemicals were examined in beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary (SLE), Canada. Blubber samples of 86 adult belugas were collected from animals stranded on the shore of the SLE between 1987 and 2002 and analyzed for several regulated PBTs, including polychlorinated biphenyls (PCBs), p,p'dichlorodiphenyltrichloroethane (DDT) and its metabolites, chlordane (CHL) and related compounds, hexachlorocyclohexane (HCH) isomers, hexachlorobenzene (HCB) and Mirex. In addition, time trends of tris(4-chlorophenyl)methane (TCPMe) and tris(4-chlorophenyl)methanol (TCPMOH), two compounds that may origin from DDT formulations, were also examined. Concentrations of most of the PBTs examined had exponentially decreased by at least a factor of two (half-life time (t(1/2))<15 years) in beluga between 1987 and 2002 while no increasing trends were observed for any of the PBTs measured. The decreasing trends of PBT concentrations in SLE beluga may be due to a decline in contamination of its diet following North American and international regulations on the use and production of these compounds or by a change in its diet itself or by a combination of both. Some PBTs did not exhibit any significant trends in beluga possibly because the most intense elimination phase subsequent to legislative regulations occurred prior to the 1987-2002 time period. Other chemicals, such gamma-HCH, did not significantly decrease likely because they are still currently used in some restricted applications. Conversely, alpha-HCH showed a significant decreasing trend indicating that SigmaHCHs is not representative of all HCHs. Both TCPMe and TCPMOH exhibited no trends in beluga during the time period examined. The metabolic capacity of SLE beluga has apparently accelerated the depletion of at least one PBT, namely CB-28/31. A significant relationship between the half-life of PBTs in beluga and log Kow was observed for

  8. Current Status and Regulatory Aspects of Pesticides Considered to be Persistent Organic Pollutants (POPs) in Taiwan

    Science.gov (United States)

    Tsai, Wen-Tien

    2010-01-01

    Organochlorine pesticides (OCPs) are capable of persisting in the environment, transporting between phase media and accumulating to high levels, implying that they could pose a risk of causing adverse effects to human health and the environment. Consequently, most OCPs are designated as persistent organic pollutants (POPs) and even as endocrine disrupting chemicals (EDCs). The objective of this paper was to review the current status of pesticide POPs in Taiwan, including aldrin, chlordane, chlordecone, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene, α/β-hexachlorocyclohexanes, lindane, mirex, pentachloro-benzene, and toxaphene. The information about their environmental properties, banned use, carcinogenic toxicity and environmental levels, can be connected with the regulatory infrastructure, which has been established by the joint-venture of the central competent authorities (i.e., Environmental Protection Administration, Department of Health, Council of Agriculture, and Council of Labor Affairs). The significant progress to be reported is that the residual levels of these pesticide-POPs, ranging from trace amounts to a few ppb, have declined notably in recent years. PMID:21139852

  9. ERP indices of persisting and current inhibitory control: a study of saccadic task switching.

    Science.gov (United States)

    Mueller, S C; Swainson, R; Jackson, G M

    2009-03-01

    Previous studies have found that inhibition of a biologically dominant prepotent response tendency is required during the execution of a less familiar, non-prepotent response. However, the lasting impact of this inhibition and the cognitive mechanisms to flexibly switch between prepotent and non-prepotent responses are poorly understood. We examined the neurophysiological (ERP) correlates of switching between prosaccade and antisaccade responses in 22 healthy volunteers. The behavioural data showed significant switch costs in terms of response latency for the prosaccade task only. These costs occurred exclusively in trials when preparation for the switch was limited to 300 ms, suggesting that inhibition of the prepotent prosaccade task either passively dissipated or was actively overcome during the longer 1000 ms preparation interval. In the neurophysiological data, a late frontal negativity (LFN) was visible during preparation for a switch to the prosaccade task that was absent when switching to the antisaccade task, which may reflect the overcoming of persisting inhibition. During task implementation both saccade types were associated with a late parietal positivity (LPP) for switch relative to repetition trials, possibly indicating attentional reorienting to the switched-to task, and visible only with short preparation intervals. When the prosaccade and antisaccade task were contrasted directly during task implementation, the antisaccade task exhibited increased stimulus-locked N2 and decreased P3 amplitudes indicative of active inhibition. The present findings indicate that neurophysiological markers of persisting and current inhibition can be revealed using a prosaccade/antisaccade-switching task.

  10. Current Status and Regulatory Aspects of Pesticides Considered to be Persistent Organic Pollutants (POPs in Taiwan

    Directory of Open Access Journals (Sweden)

    Wen-Tien Tsai

    2010-10-01

    Full Text Available Organochlorine pesticides (OCPs are capable of persisting in the environment, transporting between phase media and accumulating to high levels, implying that they could pose a risk of causing adverse effects to human health and the environment. Consequently, most OCPs are designated as persistent organic pollutants (POPs and even as endocrine disrupting chemicals (EDCs. The objective of this paper was to review the current status of pesticide POPs in Taiwan, including aldrin, chlordane, chlordecone, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene, α/β-hexachlorocyclohexanes, lindane, mirex, pentachloro-benzene, and toxaphene. The information about their environmental properties, banned use, carcinogenic toxicity and environmental levels, can be connected with the regulatory infrastructure, which has been established by the joint-venture of the central competent authorities (i.e., Environmental Protection Administration, Department of Health, Council of Agriculture, and Council of Labor Affairs. The significant progress to be reported is that the residual levels of these pesticide-POPs, ranging from trace amounts to a few ppb, have declined notably in recent years.

  11. Getting on with persistent pollutants: Decreasing trends of perfluoroalkyl acids (PFAAs) in sewage sludge.

    Science.gov (United States)

    Ulrich, Hanna; Freier, Korbinian P; Gierig, Michael

    2016-10-01

    Sewage sludge can be a relevant source of perfluoroalkyl acids (PFAAs) for the environment. In order to reduce emissions from this source, Bavarian authorities enforced in 2008 an analysis of PFAAs from sewage sludge derived from municipal wastewater treatment plants (WWTPs). 4981 sludge samples from 1165 different WWTPs were analyzed between 2008 and 2013 for 11 PFAAs compounds. During this period, 71 WWTPs exceeded the precautionary limit of 125 μg kg(-1) dm of total PFAAs in sludge samples at least once with a decreasing tendency. The yearly exceedances of the investigated WWTPs decreased from 6% in 2008 to 0.8% in 2013. At the same time, the percentage of uncontaminated WWTPs increased from 33% to 65%. Perfluorooctane sulfonic acid (PFOS) was the predominant compound found in 41% of all sludge samples. Perfluorodecanoic acid (PFDA) was detected in 19% and Perfluorooctanoic acid (PFOA) in 7%. Very high PFAAs concentrations (>500 μg kg(-1) dm) in sewage sludge were generally caused by firefighting foams containing PFAAs or emissions from PFAAs-using industries including metal plating, textile, leather or paper industries. Trend analyses of the six year period show that PFAAs contamination in sewage sludge clearly decreased for 47% of the WWTPs. However, for 16% of the WWTPs an increasing trend was detected, even though the concentration levels were below the precautionary limit. During the six years of investigation the load of total PFAAs in sewage sludge was reduced by more than 90%, from 17 t a(-1) in 2008 to 1.5 t a(-1) in 2013.

  12. Increased Persistent Sodium Current Causes Neuronal Hyperexcitability in the Entorhinal Cortex of Fmr1 Knockout Mice.

    Science.gov (United States)

    Deng, Pan-Yue; Klyachko, Vitaly A

    2016-09-20

    Altered neuronal excitability is one of the hallmarks of fragile X syndrome (FXS), but the mechanisms underlying this critical neuronal dysfunction are poorly understood. Here, we find that pyramidal cells in the entorhinal cortex of Fmr1 KO mice, an established FXS mouse model, display a decreased AP threshold and increased neuronal excitability. The AP threshold changes in Fmr1 KO mice are caused by increased persistent sodium current (INaP). Our results indicate that this abnormal INaP in Fmr1 KO animals is mediated by increased mGluR5-PLC-PKC (metabotropic glutamate receptor 5/phospholipase C/protein kinase C) signaling. These findings identify Na(+) channel dysregulation as a major cause of neuronal hyperexcitability in cortical FXS neurons and uncover a mechanism by which abnormal mGluR5 signaling causes neuronal hyperexcitability in a FXS mouse model.

  13. Increased Persistent Sodium Current Causes Neuronal Hyperexcitability in the Entorhinal Cortex of Fmr1 Knockout Mice

    Directory of Open Access Journals (Sweden)

    Pan-Yue Deng

    2016-09-01

    Full Text Available Altered neuronal excitability is one of the hallmarks of fragile X syndrome (FXS, but the mechanisms underlying this critical neuronal dysfunction are poorly understood. Here, we find that pyramidal cells in the entorhinal cortex of Fmr1 KO mice, an established FXS mouse model, display a decreased AP threshold and increased neuronal excitability. The AP threshold changes in Fmr1 KO mice are caused by increased persistent sodium current (INaP. Our results indicate that this abnormal INaP in Fmr1 KO animals is mediated by increased mGluR5-PLC-PKC (metabotropic glutamate receptor 5/phospholipase C/protein kinase C signaling. These findings identify Na+ channel dysregulation as a major cause of neuronal hyperexcitability in cortical FXS neurons and uncover a mechanism by which abnormal mGluR5 signaling causes neuronal hyperexcitability in a FXS mouse model.

  14. Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability

    Science.gov (United States)

    Paul, Jodi R.; Dewoskin, Daniel; McMeekin, Laura J.; Cowell, Rita M.; Forger, Daniel B.; Gamble, Karen L.

    2016-11-01

    How neurons encode intracellular biochemical signalling cascades into electrical signals is not fully understood. Neurons in the central circadian clock in mammals provide a model system to investigate electrical encoding of biochemical timing signals. Here, using experimental and modelling approaches, we show how the activation of glycogen synthase kinase 3 (GSK3) contributes to neuronal excitability through regulation of the persistent sodium current (INaP). INaP exhibits a day/night difference in peak magnitude and is regulated by GSK3. Using mathematical modelling, we predict and confirm that GSK3 activation of INaP affects the action potential afterhyperpolarization, which increases the spontaneous firing rate without affecting the resting membrane potential. Together, these results demonstrate a crucial link between the molecular circadian clock and electrical activity, providing examples of kinase regulation of electrical activity and the propagation of intracellular signals in neuronal networks.

  15. Trends, noise and re-entrant long-term persistence in Arctic sea ice

    Science.gov (United States)

    Agarwal, Sahil; Moon, Woosok; Wettlaufer, John

    2014-05-01

    We examine the long-term correlations and multi-fractal properties of daily satellite retrievals of Arctic sea ice albedo and extent, for periods of approximately 23 years and 32 years, respectively. The approach harnesses a recent development called multi-fractal temporally weighted detrended fluctuation analysis, which exploits the intuition that points closer in time are more likely to be related than distant points. In both datasets, we extract multiple crossover times, as characterized by generalized Hurst exponents, ranging from synoptic to decadal. The method goes beyond treatments that assume a single decay scale process, such as a first-order autoregression, which cannot be justifiably fitted to these observations. Importantly, the strength of the seasonal cycle 'masks' long-term correlations on time scales beyond seasonal. When removing the seasonal cycle from the original record, the ice extent data exhibit white noise behaviour from seasonal to bi-seasonal time scales, whereas the clear fingerprints of the short (weather) and long (approx. 7 and 9 year) time scales remain, the latter associated with the recent decay in the ice cover. Therefore, long-term persistence is re-entrant beyond the seasonal scale and it is not possible to distinguish whether a given ice extent minimum/maximum will be followed by a minimum/maximum that is larger or smaller in magnitude.

  16. Contamination status of persistent organochlorines in human breast milk from Japan: recent levels and temporal trend.

    Science.gov (United States)

    Kunisue, Tatsuya; Muraoka, Masayoshi; Ohtake, Masako; Sudaryanto, Agus; Minh, Nguyen Hung; Ueno, Daisuke; Higaki, Yumi; Ochi, Miyuki; Tsydenova, Oyuna; Kamikawa, Satoko; Tonegi, Tomoyuki; Nakamura, Yumi; Shimomura, Hiroshi; Nagayama, Junya; Tanabe, Shinsuke

    2006-08-01

    Contamination levels of persistent organochlorines (OCs) such as polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyls (PCBs), dichlorodiphenyltrichloroethane and its metabolites (DDTs), hexachlorocyclohexane isomers (HCHs), hexachlorobenzene (HCB), and chlordane compounds (CHLs) was examined in human breast milk collected during 2001-2004 from Fukuoka prefecture in Japan. The concentrations of OCs such as dioxins and related compounds, DDTs, CHLs and HCB in human breast milk from primiparae were comparable to or slightly higher than the data obtained during 1998, indicating that the levels of these contaminants in Japanese human breast milk have not decreased since 1998 and Japanese are continuously exposed to these chemicals, presumably via fish intake. In addition, OC levels in human breast milk from primiparae were significantly higher than those from multiparae, implying elimination of OCs via lactation. Furthermore, significant positive correlations were observed between levels of OCs in human breast milk and the age of primiparae. These results indicate that the mothers with higher age may transfer higher amounts of OCs to the first infant than to the infants born afterwards through breast-feeding, and hence the first born children might be at higher risk by OCs.

  17. Baicalein reverts L-valine-induced persistent sodium current up-modulation in primary cortical neurons.

    Science.gov (United States)

    Caioli, Silvia; Candelotti, Elena; Pedersen, Jens Z; Saba, Luana; Antonini, Alessia; Incerpi, Sandra; Zona, Cristina

    2016-04-01

    L-valine is a branched-chain amino acid (BCAA) largely used as dietary integrator by athletes and involved in some inherited rare diseases such as maple syrup urine disease. This pathology is caused by an altered BCAA metabolism with the accumulation of toxic keto acids in tissues and body fluids with consequent severe neurological symptoms. In animal models of BCAA accumulation, increased oxidative stress levels and lipid peroxidation have been reported. The aim of this study was to analyze both whether high BCAA concentrations in neurons induce reactive oxygen species (ROS) production and whether, by performing electrophysiological recordings, the neuronal functional properties are modified. Our results demonstrate that in primary cortical cultures, a high dose of valine increases ROS production and provokes neuronal hyperexcitability because the action potential frequencies and the persistent sodium current amplitudes increase significantly compared to non-treated neurons. Since Baicalein, a flavone obtained from the Scutellaria root, has been shown to act as a strong antioxidant with neuroprotective effects, we evaluated its possible antioxidant activity in primary cortical neurons chronically exposed to L-valine. The preincubation of cortical neurons with Baicalein prevents the ROS production and is able to revert both the neuronal hyperexcitability and the increase of the persistent sodium current, indicating a direct correlation between the ROS production and the altered physiological parameters. In conclusion, our data show that the electrophysiological alterations of cortical neurons elicited by high valine concentration are due to the increase in ROS production, suggesting much caution in the intake of BCAA dietary integrators.

  18. Extracellular calcium modulates persistent sodium current-dependent burst-firing in hippocampal pyramidal neurons.

    Science.gov (United States)

    Su, H; Alroy, G; Kirson, E D; Yaari, Y

    2001-06-15

    The generation of high-frequency spike bursts ("complex spikes"), either spontaneously or in response to depolarizing stimuli applied to the soma, is a notable feature in intracellular recordings from hippocampal CA1 pyramidal cells (PCs) in vivo. There is compelling evidence that the bursts are intrinsically generated by summation of large spike afterdepolarizations (ADPs). Using intracellular recordings in adult rat hippocampal slices, we show that intrinsic burst-firing in CA1 PCs is strongly dependent on the extracellular concentration of Ca(2+) ([Ca(2+)](o)). Thus, lowering [Ca(2+)](o) (by equimolar substitution with Mn(2+) or Mg(2+)) induced intrinsic bursting in nonbursters, whereas raising [Ca(2+)](o) suppressed intrinsic bursting in native bursters. The induction of intrinsic bursting by low [Ca(2+)](o) was associated with enlargement of the spike ADP. Low [Ca(2+)](o)-induced intrinsic bursts and their underlying ADPs were suppressed by drugs that reduce the persistent Na(+) current (I(NaP)), indicating that this current mediates the slow burst depolarization. Blocking Ca(2+)-activated K(+) currents with extracellular Ni(2+) or intracellular chelation of Ca(2+) did not induce intrinsic bursting. This and other evidence suggest that lowering [Ca(2+)](o) may induce intrinsic bursting by augmenting I(NaP). Because repetitive neuronal activity in the hippocampus is associated with marked decreases in [Ca(2+)](o), the regulation of intrinsic bursting by extracellular Ca(2+) may provide a mechanism for preferential recruitment of this firing mode during certain forms of hippocampal activation.

  19. Overview Chapter 4: Changing family and partnership behaviour: Common trends and persistent diversity across Europe

    Directory of Open Access Journals (Sweden)

    Laurent Toulemon

    2008-07-01

    Full Text Available Following the era of the 'golden age of marriage' and the baby boom in the 1950s and 1960s, marriage has declined in importance, and its role as the main institution on which family relations are built has been eroded across Europe. Union formation most often takes place without a marriage. Family and living arrangements are currently heterogeneous across Europe, but all countries seem to be making the same shifts: towards fewer people living together as a couple, especially in marriage; an increased number of unmarried couples; more children born outside marriage; and fewer children living with their two parents. The relationship between these changing living arrangements, especially the decline of marriage, on the one hand, and the overall level of fertility, on the other, is not straightforward. In most countries, marriage rates and fertility declined simultaneously. However, the aggregate relationship between marriage and fertility indices has moved from negative (fewer marriages imply fewer births to positive (fewer marriages imply more births. Thus, the decline of marriage, which is a part of the second demographic transition (see Overview Chapter 6, cannot be considered an important cause of the current low fertility level in many European countries. On the contrary, in European countries where the decline of marriage has been less pronounced, fertility levels are currently lower than in countries where new living arrangements have become most common.

  20. Contribution of persistent sodium current to locomotor pattern generation in neonatal rats.

    Science.gov (United States)

    Tazerart, Sabrina; Viemari, Jean-Charles; Darbon, Pascal; Vinay, Laurent; Brocard, Frédéric

    2007-08-01

    The persistent sodium current (I(NaP)) is known to play a role in rhythm generation in different systems. Here, we investigated its contribution to locomotor pattern generation in the neonatal rat spinal cord. The locomotor network is mainly located in the ventromedial gray matter of upper lumbar segments. By means of whole cell recordings in slices, we characterized membrane and I(NaP) biophysical properties of interneurons located in this area. Compared with motoneurons, interneurons were more excitable, because of higher input resistance and membrane time constant, and displayed lower firing frequency arising from broader spikes and longer AHPs. Ramp voltage-clamp protocols revealed a riluzole- or TTX-sensitive inward current, presumably I(NaP), three times smaller in interneurons than in motoneurons. However, in contrast to motoneurons, I(NaP) mediated a prolonged plateau potential in interneurons after reducing K(+) and Ca(2+) currents. We further used in vitro isolated spinal cord preparations to investigate the contribution of I(NaP) to locomotor pattern. Application of riluzole (10 muM) to the whole spinal cord or to the upper lumbar segments disturbed fictive locomotion, whereas application of riluzole over the caudal lumbar segments had no effect. The effects of riluzole appeared to arise from a specific blockade of I(NaP) because action potential waveform, dorsal root-evoked potentials, and miniature excitatory postsynaptic currents were not affected. This study provides new functional features of ventromedial interneurons, with the first description of I(NaP)-mediated plateau potentials, and new insights into the operation of the locomotor network with a critical implication of I(NaP) in stabilizing the locomotor pattern.

  1. Phenytoin inhibits the persistent sodium current in neocortical neurons by modifying its inactivation properties.

    Directory of Open Access Journals (Sweden)

    Elisa Colombo

    Full Text Available The persistent Na⁺ current (I(NaP is important for neuronal functions and can play a role in several pathologies, although it is small compared to the transient Na⁺ current (I(NaT. Notably, I(NaP is not a real persistent current because it undergoes inactivation with kinetics in the order of tens of seconds, but this property has often been overlooked. Na⁺ channel blockers, drugs used for treating epilepsy and other diseases, can inhibit I(NaP, but the mechanism of this action and the conditions in which I(NaP can be actually inhibited have not been completely clarified yet. We evaluated the action of phenytoin (PHT, a prototype anti-epileptic Na⁺ channel blocker, on I(NaP inactivation in pyramidal neurons of rat sensorimotor cortical slices at different concentrations, from 5 to 100 µM. PHT did not modify I(NaP evoked with depolarizing voltage ramps of 50 or 100 mVs⁻¹, but decreased I(NaP evoked by slower voltage ramps (10 mVs⁻¹. However, at all of the tested concentrations, PHT decreased I(NaP evoked by faster ramps when they were preceded by inactivating pre-pulses. Moreover, PHT shifted towards negative potentials the voltage-dependence of I(NaP inactivation and accelerated its kinetics of development also at depolarized potentials (+40 mV, not consistently with a simple inactivated state stabilizer. Therefore, our study shows a prominent PHT effect on I(NaP inactivation rather than an open channel block, which is instead often implied. I(NaP is inhibited by PHT only in conditions that induce major I(NaP inactivation. These results highlight the importance of I(NaP inactivation not only for physiological functions but also as drug target, which could be shared by other therapeutic drugs. Through this action PHT can reduce I(NaP-induced long-lasting pathological depolarisations and intracellular sodium overload, whereas shorter I(NaP actions should not be modified. These properties set the conditions of efficacy and the limits

  2. Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes

    Institute of Scientific and Technical Information of China (English)

    Ji-hua MA; An-tao LUO; Pei-hua ZHANG

    2005-01-01

    Aim: To study the effect of hydrogen peroxide (H2O2) on persistent sodium current (INa.P) in guinea pig ventricular myocytes.Methods: The whole-cell, cell-attached, and inside-out patch-clamp techniques were applied on isolated ventricular myocytes from guinea pig.Results: H2O2 (0.1 mmol/L, 0.5 mmol/L and 1.0mmol/L) increased the amplitude of whole-cell INa.P in a concentration-dependent mmol/L) increased persistent sodium channel activity in cell-attached and insideout patches.The mean open probability was increased from control values of 0.015±0.004 and 0.012±0.003 to 0.106±0.011 and 0.136±0.010, respectively (P<0.01 vs control).They were then decreased to 0.039±0.024 and 0.027±0.006,respectively, after the addition of 1 mmol/L GSH (P<0.01 vs H2O2).The time when open probability began to increase and reached a maximum was shorter in insideout patches than that in cell-attached patches (4.8± 1.0 min vs 11.5±3.9 min, P<0.01;9.6±1.6 min vs 18.7±4.7 min, P<0.01).Conclusion: H2O2 increased the INa.P of guinea pig ventricular myocytes in a concentration-dependent manner, possibly by directly oxidating the cell membrane.

  3. Role of persistent sodium current in bursting activity of mouse neocortical networks in vitro.

    Science.gov (United States)

    van Drongelen, Wim; Koch, Henner; Elsen, Frank P; Lee, Hyong C; Mrejeru, Ana; Doren, Erin; Marcuccilli, Charles J; Hereld, Mark; Stevens, Rick L; Ramirez, Jan-Marino

    2006-11-01

    Most types of electrographic epileptiform activity can be characterized by isolated or repetitive bursts in brain electrical activity. This observation is our motivation to determine mechanisms that underlie bursting behavior of neuronal networks. Here we show that the persistent sodium (Na(P)) current in mouse neocortical slices is associated with cellular bursting and our data suggest that these cells are capable of driving networks into a bursting state. This conclusion is supported by the following observations. 1) Both low concentrations of tetrodotoxin (TTX) and riluzole reduce and eventually stop network bursting while they simultaneously abolish intrinsic bursting properties and sensitivity levels to electrical stimulation in individual intrinsically bursting cells. 2) The sensitivity levels of regular spiking neurons are not significantly affected by riluzole or TTX at the termination of network bursting. 3) Propagation of cellular bursting in a neuronal network depended on excitatory connectivity and disappeared on bath application of CNQX (20 microM) + CPP (10 microM). 4) Voltage-clamp measurements show that riluzole (20 microM) and very low concentrations of TTX (50 nM) attenuate Na(P) currents in the neural membrane within a 1-min interval after bath application of the drug. 5) Recordings of synaptic activity demonstrate that riluzole at this concentration does not affect synaptic properties. 6) Simulations with a neocortical network model including different types of pyramidal cells, inhibitory interneurons, neurons with and without Na(P) currents, and recurrent excitation confirm the essence of our experimental observations that Na(P) conductance can be a critical factor sustaining slow population bursting.

  4. The Future of School Social Work Practice: Current Trends and Opportunities

    Directory of Open Access Journals (Sweden)

    Cynthia Franklin

    2005-05-01

    Full Text Available This article discusses the information on school social work practice in the United States and summarizes recent trends and their implications for the future of school social work. The number of school social workers and current infrastructure available for the development of school social work practice is reviewed. Five sociocultural trends are summarized that are affecting public schools as well as important school-based practice trends such as standardized testing, and high stakes accountability measures. The emerging practice trend of evidence-based practices is discussed in light of its standards and implications for school-based practice. Finally, essential knowledge for strengthening practice competencies to meet the future challenges of school-based practice is highlight.

  5. Electron-phonon interaction effect on persistent current in a one-dimensional quantum ring by using a simple model

    Science.gov (United States)

    Omidi, Mahboubeh; Faizabadi, Edris

    2015-09-01

    We use a simple model to study the electron-phonon interaction influences on persistent current in a one-dimensional quantum ring enclosed by a magnetic flux. With increasing the temperature, persistent current amplitude is reduced, especially in a quantum ring with two ions per primitive cell (diatomic ring) because of the participation of optical phonons. Furthermore, the periodicity of the Aharonov-Bohm oscillations changes to Φ0 / 2 (Φ0 is magnetic flux quantum). In a diatomic ring, by increasing the difference between left and right nearest-neighbor hopping integrals at zero temperature, persistent current variations show a transition from metallic to insulator against distinctive behavior at nonzero temperature.

  6. State-dependent modulation of gap junction signaling by the persistent sodium current.

    Science.gov (United States)

    Haas, Julie S; Landisman, Carole E

    2011-01-01

    THALAMIC NEURONS FLUCTUATE BETWEEN TWO STATES: a hyperpolarized state associated with burst firing and sleep spindles, and a depolarized state associated with tonic firing and rapid, reliable information transmission between the sensory periphery and cortex. The thalamic reticular nucleus (TRN) plays a central role in thalamocortical processing by providing feed-forward and feedback inhibition to thalamic relay cells; TRN cells participate in the generation of sleep spindles, and have been suggested to focus the neural "searchlight" of attention. The mechanisms underlying synchrony in the TRN during different behavioral states are largely unknown. TRN cells are densely interconnected by electrical synapses. Here we show that activation of the persistent sodium current (I(NaP)) by depolarization causes up to fourfold changes in electrical synaptic efficacy between TRN neurons. We further show that amplification of electrical synaptic responses strongly enhances tonic spike synchrony but, surprisingly, does not affect burst coordination. We use a Hodgkin-Huxley model to gain insight into the differences between the effects of burstlets, spikelets, and amplification on burst and spike times.

  7. Persistent sodium current properties in hippocampal CA1 pyramidal neurons of young and adult rats.

    Science.gov (United States)

    Lunko, Oleksii; Isaev, Dmytro; Maximyuk, Oleksandr; Ivanchick, Gleb; Sydorenko, Vadym; Krishtal, Oleg; Isaeva, Elena

    2014-01-24

    Persistent tetrodotoxin-sensitive sodium current (INaP) plays an important role in cellular and neuronal network excitability in physiological conditions and under different pathological circumstances. However, developmental changes in INaP properties remain largely unclear. In the present study using whole cell patch clamp technique we evaluated INaP properties in CA1 hippocampal pyramidal neurons isolated from young (postnatal day (P) 12-16) and adult (P60-75) rats. We show that the INaP density is substantially larger in the adult group. Although INaP inactivation characteristics were found to be similar in both groups, voltage dependence of INaP activation is shifted to more negative membrane potentials (young: -48.6±0.5mV vs. adult: -52.4±0.2mV, p<0.01). Our data indicates the increase of INaP contribution in the basal membrane sodium conductivity in the mature hippocampus.

  8. Persistent sodium currents participate in fictive locomotion generation in neonatal mouse spinal cord.

    Science.gov (United States)

    Zhong, Guisheng; Masino, Mark A; Harris-Warrick, Ronald M

    2007-04-25

    The persistent sodium current (I(Na(P))) has been implicated in the regulation of synaptic integration, intrinsic membrane properties, and rhythm generation in many types of neurons. We characterized I(Na(P)) in commissural interneurons (CINs) in the neonatal (postnatal days 0-3) mouse spinal cord; it is activated at subthreshold potentials, inactivates slowly, and can be blocked by low concentrations of riluzole. The role of I(Na(P)) in locomotor pattern generation was examined by applying riluzole during fictive locomotion induced by NMDA, serotonin, and dopamine or by stimulation of the cauda equina. Blockade of I(Na(P)) has marginal effects on the locomotion frequency but progressively weakens the rhythmic firing and locomotor-related membrane oscillation of CINs and motoneurons (MNs) and the locomotor-like bursts in ventral roots, until the motor pattern ceases. Riluzole directly affects the intrinsic firing properties of CINs and MNs, reducing their ability to fire repetitively during tonic depolarizations and raising their spike threshold. At the same time, riluzole has little effects on the strength of spike-evoked synaptic transmission onto CINs and MNs. Our results suggest that I(Na(P)) is essential for the generation of the locomotor pattern and acts in part by regulating the frequency of interneuron firing in the central pattern generator for locomotion.

  9. Thrombin modulates persistent sodium current in CA1 pyramidal neurons of young and adult rat hippocampus.

    Science.gov (United States)

    Lunko, O O; Isaev, D S; Krishtal, O O; Isaeva, E V

    2015-01-01

    Serine protease thrombin, a key factor of blood coagulation, participates in many neuronal processes important for normal brain functioning and during pathological conditions involving abnormal neuronal synchronization, neurodegeneration and inflammation. Our previous study on CA3 pyramidal neurons showed that application ofthrombin through the activation of specific protease-activated receptor 1 (PAR1) produces a significant hyperpolarizing shift of the activation of the TTX-sensitive persistent voltage-gated Na+ current (I(Nap)) thereby affecting membrane potential and seizure threshold at the network level. It was shown that PAR1 is also expressed in CA1 area of hippocampus and can be implicated in neuronal damage in this area after status epilepticus. The aim of the present study was to evaluate the effect of thrombin on I(NaP) in CA1 pyramidal neurons from adult and young rats. Using whole cell patch-clamp technique we demonstrate that thrombin application results in the hyperpolarization shift of I(NaP) activation as well as increase in the I(NaP) amplitude in both age groups. We have found that I(NaP) in pyramidal neurons of hippocampal CA 1 region is more vulnerable to the thrombin action than I(NaP) in pyramidal neurons of hippocampal CA3 region. We have also found that the immature hippocampus is more sensitive to thrombin action which emphasizes the contribution of thrombin-dependent pathway to the regulation of neuronal activity in immature brain.

  10. Finite-size effects in a metallic multichannel ring with Kondo impurity: Persistent currents and magnetoresistance

    Energy Technology Data Exchange (ETDEWEB)

    Zvyagin, A.A. [B. I. Verkin Institute for Low Temperature Physics and Engineering of the National Ukrainian Academy of Sciences, 47, Lenin Avenue, 310164, Kharkov (Ukraine); Schlottmann, P. [Department of Physics, Florida State University, Tallahassee, Florida 32306 (United States)

    1996-12-01

    We consider a spin-1/2 impurity interacting with conduction electrons in two different orbital channels via an isotropic spin exchange. The exchange is the same for both channels, but a crystalline field breaks the symmetry between the orbital channels. This corresponds to a splitting of the conduction electron {Gamma}{sub 8} into two doublets in the quadrupolar Kondo effect, or to the electron-assisted tunneling of an atom in a double-well potential in an external magnetic field. Another possible realization could be a quantum dot coupled to two equal rings of the same length subject to an electrostatic potential difference. We consider the Bethe ansatz equations for this model and derive the tower structure of the finite-size corrections to the ground-state energy. These results are used to discuss the Aharonov-Bohm-Casher interference pattern in the persistent charge and spin currents, and the magnetoresistivity due to the scattering of electrons off the impurity. {copyright} {ital 1996 The American Physical Society.}

  11. State-dependent modulation of gap junction signaling by the persistent sodium current

    Directory of Open Access Journals (Sweden)

    Julie S Haas

    2012-01-01

    Full Text Available Thalamic neurons fluctuate between two states: a hyperpolarized state associated with burst firing and sleep spindles, and a depolarized state associated with tonic firing and rapid, reliable information transmission between the sensory periphery and cortex. The thalamic reticular nucleus (TRN plays a central role in thalamocortical processing by providing feed-forward and feedback inhibition to thalamic relay cells; TRN cells participate in the generation of sleep spindles, and have been suggested to focus the neural searchlight of attention. The mechanisms underlying synchrony in the TRN during different behavioral states are largely unknown. TRN cells are densely interconnected by electrical synapses. Here we show that activation of the persistent sodium current (INaP by depolarization causes up to four-fold changes in electrical synaptic efficacy between TRN neurons. We further show that amplification of electrical synaptic responses strongly enhances tonic spike synchrony but, surprisingly, does not affect burst coordination. We use a Hodgkin-Huxley model to gain insight into the differences between the effects of burstlets, spikelets and amplification on burst and spike times.

  12. TRENDS AND STRUCTURAL CHANGES ON THE GAS MARKET UNDER CURRENT CONDITIONS

    Directory of Open Access Journals (Sweden)

    Andrei E. Shmagin

    2013-01-01

    Full Text Available The popularity of natural gas as an energy source increasingly grows. The rate of demand growth and the gas market development depend on a variety of key conditions discussed in the paper. The current market situation and trends are analyzed in the context of the global balance of energy.

  13. TRENDS AND STRUCTURAL CHANGES ON THE GAS MARKET UNDER CURRENT CONDITIONS

    OpenAIRE

    Andrei E. Shmagin

    2013-01-01

    The popularity of natural gas as an energy source increasingly grows. The rate of demand growth and the gas market development depend on a variety of key conditions discussed in the paper. The current market situation and trends are analyzed in the context of the global balance of energy.

  14. Current Trends in Communication Graduate Degrees: Survey of Communications, Advertising, PR, and IMC Graduate Programs

    Science.gov (United States)

    Quesenberry, Keith A.; Coolsen, Michael K.; Wilkerson, Kristen

    2015-01-01

    A survey of 61 master's degree advertising programs reveals significant trends in program titles, curriculum design, course delivery, and students served. The results provide insight for current and planned master's degree programs as research predicts a continued increase in demand for master's education over the next decade. Survey results are…

  15. Current Trends in English Language Testing. Conference Proceedings for CTELT 1997 and 1998, Vol. 1.

    Science.gov (United States)

    Coombe, Christine A., Ed.

    Papers from the 1997 and 1998 Current Trends in English Language Testing (CTELT) conferences include: "Computer-Based Language Testing: The Call of the Internet" (G. Fulcher); "Uses of the PET (Preliminary English Test) at Sultan Qaboos University" (R. Taylor); "Issues in Foreign and Second Language Academic Listening…

  16. Current Trends in Communication Graduate Degrees: Survey of Communications, Advertising, PR, and IMC Graduate Programs

    Science.gov (United States)

    Quesenberry, Keith A.; Coolsen, Michael K.; Wilkerson, Kristen

    2015-01-01

    A survey of 61 master's degree advertising programs reveals significant trends in program titles, curriculum design, course delivery, and students served. The results provide insight for current and planned master's degree programs as research predicts a continued increase in demand for master's education over the next decade. Survey results are…

  17. The current waste generation and management trends in South Africa: A Review

    CSIR Research Space (South Africa)

    Nkosi, N

    2013-04-01

    Full Text Available This paper, a continuation and expansion of the work of Muzenda et al, 2012 [1] looks at the current waste generation and management trends in South Africa. The waste tyre problem in South Africa is also briefly discussed. Solid waste management...

  18. Bowker, L. et al., eds. Unity in diversity? current trends in translation studies. Bowker, L. et al., eds. Unity in diversity? current trends in translation studies.

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Vasconcellos

    2008-04-01

    Full Text Available Unity in Diversity? Current Trends in Translation Studies—a result of the diverse range of phenomena addressed in the Dublin City University Translation Studies (TS Conference (1996—proves to be a timely publication of St. Jerome Publishing at the end of the 20th century. This collection of papers exploring the central and uptodate issue of disciplinary identity in the young academic field of TS is in tune with the present concern in the area, as can be seen in the topic suggested for the international Translation Conference I IATIS Conference:“Disciplinary Identity—Redefining Translation in the 21st Century” (cf. www.iatis.org/content/korea/programme.php, to be held in 2005. Unity in Diversity? Current Trends in Translation Studies—a result of the diverse range of phenomena addressed in the Dublin City University Translation Studies (TS Conference (1996—proves to be a timely publication of St. Jerome Publishing at the end of the 20th century. This collection of papers exploring the central and uptodate issue of disciplinary identity in the young academic field of TS is in tune with the present concern in the area, as can be seen in the topic suggested for the international Translation Conference I IATIS Conference:“Disciplinary Identity—Redefining Translation in the 21st Century” (cf. www.iatis.org/content/korea/programme.php, to be held in 2005.

  19. Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron.

    Science.gov (United States)

    Nikitin, E S; Kiss, T; Staras, K; O'shea, M; Benjamin, P R; Kemenes, G

    2006-01-01

    We have identified a TTX-resistant low-threshold persistent inward sodium current in the cerebral giant cells (CGCs) of Lymnaea, an important state-setting modulatory cell type of molluscan feeding networks. This current has slow voltage-dependent activation and de-activation kinetics, ultra-slow inactivation kinetics and fast de-inactivation kinetics. It activates at approximately -90 mV, peaks at approximately -30 mV, reverses at approximately +35 mV and does not show full voltage-dependent inactivation even at positive voltage steps. Lithium-sodium replacement experiments indicate that the persistent sodium current makes a significant contribution to the CGC membrane potential. Injection of cyclic adenosine monophosphate (cAMP) into the CGC cell body produces a large increase in the persistent sodium current that lasts for several hours. cAMP injection also leads to increased bursting, a significant decrease in the resistance and a significant depolarization of the soma membrane, indicating that cAMP-dependent mechanisms induce prolonged neuronal plasticity in the CGCs. Our observations provide the first link between cAMP-mediated modulation of a TTX-resistant persistent sodium current and prolonged neuronal plasticity in an identified modulatory cell type that plays an important role in behavioral state setting.

  20. Infective endocarditis prophylaxis: current practice trend among paediatric cardiologists: are we following the 2007 guidelines?

    Science.gov (United States)

    Naik, Ronak J; Patel, Neil R; Wang, Ming; Shah, Nishant C

    2016-08-01

    In 2007, the American Heart Association modified the infective endocarditis prophylaxis guidelines by limiting the use of antibiotics in patients with cardiac conditions associated with the highest risk of adverse outcomes after infective endocarditis. Our objective was to evaluate current practice for infective endocarditis prophylaxis among paediatric cardiologists. A web-based survey focussing on current practice, describing the use of antibiotics for infective endocarditis prophylaxis in various congenital and acquired heart diseases, was distributed via e-mail to paediatric cardiologists. The survey was kept anonymous and was distributed twice. Data from 253 participants were analysed. Most paediatric cardiologists discontinued infective endocarditis prophylaxis in patients with simple lesions such as small ventricular septal defect, patent ductus arteriosus, and bicuspid aortic valve without stenosis or regurgitation; however, significant disagreement persists in prescribing infective endocarditis prophylaxis in certain conditions such as rheumatic heart disease, Fontan palliation without fenestration, and the Ross procedure. Use of antibiotic prophylaxis in certain selected conditions for which infective endocarditis prophylaxis has been indicated as per the current guidelines varies from 44 to 83%. Only 44% follow the current guidelines exclusively, and 34% regularly discuss the importance of oral hygiene with their patients at risk for infective endocarditis. Significant heterogeneity still persists in recommending infective endocarditis prophylaxis for several cardiac lesions among paediatric cardiologists. More than half of the participants (56%) do not follow the current guidelines exclusively in their practice. Counselling for optimal oral health in patients at risk for infective endocarditis needs to be optimised in the current practice.

  1. Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysis.

    Science.gov (United States)

    Chatelier, Aurélien; Zhao, Juan; Bois, Patrick; Chahine, Mohamed

    2010-06-01

    Na(v)1.6 is the major voltage-gated sodium channel at nodes of Ranvier. This channel has been shown to produce a robust persistent inward current in whole-cell experiments. Na(v)1.6 plays an important role in axonal conduction and may significantly contribute to the pathophysiology of the injured nervous system through this persistent current. However, the underlying molecular mechanisms and regulation of the persistent current are not well understood. Using the whole-cell configuration of the patch-clamp technique, we investigated the Na(v)1.6 transient and persistent currents in HEK-293. Previous studies have shown that the persistent current depended on the content of the patch electrode. Therefore, we characterised the single-channel properties of the persistent current with an intact intracellular medium using the cell-attached configuration of the patch-clamp technique. In HEK-293 cells, the Na(v)1.6 persistent current recorded in the whole-cell configuration was 3-5% of the peak transient current. In single-channel recording, the ratio between peak and persistent open probability confirmed the magnitude of the persistent current observed in the whole-cell configuration. The cell-attached configuration revealed that the molecular mechanism of the whole-cell persistent current is a consequence of single Na(v)1.6 channels reopening.

  2. Current trends in the global tourism industry: evidence from the United States

    Directory of Open Access Journals (Sweden)

    Nejdet Delener

    2010-10-01

    Full Text Available Tourism is one of the largest U.S. industries, serving millions of international and domestic tourists yearly. Tourists visit the U.S. to see natural wonders, cities, historic landmarks, and entertainment venues. Americans seek similar attractions as well as recreation and vacation areas. Tourism competes in the global market, so it is important to understand current trends in the U.S. travel industry. Therefore, this article offers insight into important trends and suggests strategies for policy makers involved in the travel and tourism industry.

  3. New Member States of the European Union and the Current Trends in the World Economy

    Directory of Open Access Journals (Sweden)

    Ilya Bolotov

    2015-01-01

    Full Text Available This paper describes the specifics of the current development of the world economy and discusses implications for new member states of the European Union, the EU NMS, with a small case study on the Czech Republic. The paper is divided into four parts: the trends, the EU NMS and the effects of the trends in the EU NMS and in the Czech Republic. The paper is based on a general economic analysis of data provided by the World Bank (WB, the International Monetary Fund (IMF, Eurostat, the European Central Bank (ECB and by the Czech Statistical Office (CZSO. Being familiar with recent macroeconomic trends is nowadays important for Central and Eastern European managers in order to efficiently adapt their strategies to the constantly changing business environment.

  4. Trends

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Shanghai Mode Lingerie continually strives to underline its status as a veritable reference on the fashion scene: an opportunity to explore trends, interpret key directions and gain an in-depth overview of lines to follow.

  5. Tendencias y debates actuales en el periodismo digital/Current trends and debates in digital journalism

    National Research Council Canada - National Science Library

    Mario Morales

    2005-01-01

    ... clave: Periodismo digital, prácticas periodísticas, rutinas periodísticas. Recepción: 19 de septiembre de 2005 Aceptación: 10 de noviembre de 2005 Current trends and debates in digital journalism The Internet has come to change everything. Journalism has not been the same since the network boom. This article looks at the appreciable changes tha...

  6. Photonics industry in China: from current status and trends to the importance of innovation

    Science.gov (United States)

    Fan, Chongcheng

    2011-12-01

    Current status and trends in various sectors of photonics industry in Mainland China are reviewed, which includes optical fiber communication, optical preform, fiber and cable, photonic devices and chips, LED illumination and display, and photovoltaics. Then, from the challenges and risks they are facing, critical importance of innovation is discussed. In the evolving Innovation Economy, the core competence of a company, an industry or a country is its innovation power and the capability to grab (and manage) talented people.

  7. Current trends in pharmacy benefit designs: a threat to disease management in chronic complex diseases.

    Science.gov (United States)

    Owens, Gary; Emons, Matthew F; Christian-Herman, Jennifer; Lawless, Grant

    2007-04-01

    With a focus on those patients who are candidates for treatment with biologic agents, we review the impact that current pharmacy benefit trends have on patients with chronic complex diseases and how they affect opportunities for disease management in this unique patient population. Dramatic increases in health care costs have led to a variety of strategies to manage cost. Many of these strategies either limit access to care or increase the patient's responsibility for choosing and paying for care, especially for medications. These strategies have a disproportionate impact on patients with chronic complex diseases, particularly those who require the use of biologic medications. A fundamental prerequisite of disease management has been coverage of disease-modifying therapies. If current pharmacy benefit trends continue, unintended consequences will likely occur including lost opportunities for disease management. Current pharmacy benefit trends could adversely impact disease management, particularly for patients requiring the use of biologic agents. Health plans should consider innovative benefit designs that reflect an appropriate level of cost sharing across all key stake-holders, ensuring appropriate access to needed therapies. Additional research is needed to clarify the value of newer approaches to therapies or benefit design changes.

  8. Climatic modulation of recent trends in ocean acidification in the California Current System

    Science.gov (United States)

    Turi, G.; Lachkar, Z.; Gruber, N.; Münnich, M.

    2016-01-01

    We reconstruct the evolution of ocean acidification in the California Current System (CalCS) from 1979 through 2012 using hindcast simulations with an eddy-resolving ocean biogeochemical model forced with observation-based variations of wind and fluxes of heat and freshwater. We find that domain-wide pH and {{{Ω }}}{arag} in the top 60 m of the water column decreased significantly over these three decades by about -0.02 decade-1 and -0.12 decade-1, respectively. In the nearshore areas of northern California and Oregon, ocean acidification is reconstructed to have progressed much more rapidly, with rates up to 30% higher than the domain-wide trends. Furthermore, ocean acidification penetrated substantially into the thermocline, causing a significant domain-wide shoaling of the aragonite saturation depth of on average -33 m decade-1 and up to -50 m decade-1 in the nearshore area of northern California. This resulted in a coast-wide increase in nearly undersaturated waters and the appearance of waters with {{{Ω }}}{arag}\\lt 1, leading to a substantial reduction of habitat suitability. Averaged over the whole domain, the main driver of these trends is the oceanic uptake of anthropogenic CO2 from the atmosphere. However, recent changes in the climatic forcing have substantially modulated these trends regionally. This is particularly evident in the nearshore regions, where the total trends in pH are up to 50% larger and trends in {{{Ω }}}{arag} and in the aragonite saturation depth are even twice to three times larger than the purely atmospheric CO2-driven trends. This modulation in the nearshore regions is a result of the recent marked increase in alongshore wind stress, which brought elevated levels of dissolved inorganic carbon to the surface via upwelling. Our results demonstrate that changes in the climatic forcing need to be taken into consideration in future projections of the progression of ocean acidification in coastal upwelling regions.

  9. Current Approaches to the Choice of Basic Therapy for Mild Persistent Bronchial Asthma in Children

    Directory of Open Access Journals (Sweden)

    S.M. Nedelska

    2015-04-01

    Conclusions. Leukotrien modifier as monotherapy is indicated to 6–7-year-old children with mild persistent bronchial asthma and serum levels of leukotrienes from 500 to 1000 pg/ml. At the level of leukotrienes below 500 pg/ml it is advisable to administer fluticasone propionate, above 1000 pg/ml — combination of leukotrien modifier and inhaled corticosteroid.

  10. The current state and trends of the development of universities in Ukraine

    Directory of Open Access Journals (Sweden)

    O.B. Morhulets

    2015-09-01

    Full Text Available Education is the basis of social, political, economic, spiritual, and cultural development. Therefore, the study of the current state and trends of the development of Ukrainian universities is a significant factor of social and economic progress of the country.The paper reflects the general state of universities in Ukraine, in particular, the trends in dynamics: the number of students in terms of entry/graduation, sources of financing, education fields; the number of universities in the context of accreditation, types and forms of ownership; the number of outbound Ukrainian and inbound foreign students; quantitative and qualitative characteristics of teaching staff; spending on higher education and the cost of funding per student compared with other countries. The purpose of the study is the assessment of economic activity of higher educational establishments in Ukraine, the identification of problems and tendencies of their development in the context of national transformational processes in education and formation of the society of knowledge. The methodical base used in the study is analysis and synthesis, methods of comparison and generalization, extrapolation, index and graphical methods. The practical value of the study is based on the results of a thorough analysis of university activities. Such results reveal the current state and trends of the development of universities under conditions of higher education transformation in Ukraine and its integration into the European educational area. The results of research improve understanding of the state and problems of the universities and provide the foundations for further research in the field of the national education system development and for improving of the quality of young professionals’ training. The trends of the university development indicate that the reorganization of higher education which is being currently taken place, already results in the emergence of new competencies of

  11. CURRENT TRENDS FOR DEVELOPMENT AND IMPROVEMENT OF THE ORGANIZATIONAL STRUCTURES IN MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Angel Doraliyski

    2017-03-01

    Full Text Available One of the key components of the management system is the organizational structure of management. This report presents the current trends of development and improvement of organizational structures of management. The semantics of the term "organizational structure" used in the report is clarified. Key aspects of structural policy of organizations are discussed, as well as the introduction of flexible organizational forms. The main directions for analysis of organizational policy of organizations are also mentioned. It is stressed that the analysis of current trends for the future development of organizational structures of management should be an integral component of the management policy of every organization. The trends are flexibility and adaptability of the organizational structure, rational proportion between centralization and decentralization, an appropriate balance between the rights, duties and responsibilities, reducing regulations, rules and other normative documents. A recommendetaion is made that organizational governance structures must be adapted constantly in accordance with changes in the overall management system, as they are one of its main components.

  12. Generation of geometrical phases and persistent spin currents in 1-dimensional rings by Lorentz-violating terms

    CERN Document Server

    Casana, R; Mouchrek-Santos, V E; Silva, Edilberto O

    2015-01-01

    We have demonstrated that Lorentz-violating terms stemming from the fermion sector of the SME are able to generate geometrical phases on the wave function of electrons confined in 1-dimensional rings, as well as persistent spin currents, in the total absence of electromagnetic fields. We have explicitly evaluated the eigenenergies and eigenspinors of the electrons modified by the Lorentz-violating terms, using them to calculate the dynamic and the Aharonov-Anandan phases in the sequel. The total phase presents a pattern very similar to the Aharonov-Casher phase accumulated by electrons in rings under the action of the Rashba interaction. Finally, the persistent spin current were carried out and used to impose upper bounds on the Lorentz-violating parameters.

  13. Generation of geometrical phases and persistent spin currents in 1-dimensional rings by Lorentz-violating terms

    Directory of Open Access Journals (Sweden)

    R. Casana

    2015-06-01

    Full Text Available We have demonstrated that Lorentz-violating terms stemming from the fermion sector of the SME are able to generate geometrical phases on the wave function of electrons confined in 1-dimensional rings, as well as persistent spin currents, in the total absence of electromagnetic fields. We have explicitly evaluated the eigenenergies and eigenspinors of the electrons modified by the Lorentz-violating terms, using them to calculate the dynamic and the Aharonov–Anandan phases in the sequel. The total phase presents a pattern very similar to the Aharonov–Casher phase accumulated by electrons in rings under the action of the Rashba interaction. Finally, the persistent spin current were carried out and used to impose upper bounds on the Lorentz-violating parameters.

  14. Generation of geometrical phases and persistent spin currents in 1-dimensional rings by Lorentz-violating terms

    Energy Technology Data Exchange (ETDEWEB)

    Casana, R.; Ferreira, M.M., E-mail: manojr.ufma@gmail.com; Mouchrek-Santos, V.E.; Silva, Edilberto O.

    2015-06-30

    We have demonstrated that Lorentz-violating terms stemming from the fermion sector of the SME are able to generate geometrical phases on the wave function of electrons confined in 1-dimensional rings, as well as persistent spin currents, in the total absence of electromagnetic fields. We have explicitly evaluated the eigenenergies and eigenspinors of the electrons modified by the Lorentz-violating terms, using them to calculate the dynamic and the Aharonov–Anandan phases in the sequel. The total phase presents a pattern very similar to the Aharonov–Casher phase accumulated by electrons in rings under the action of the Rashba interaction. Finally, the persistent spin current were carried out and used to impose upper bounds on the Lorentz-violating parameters.

  15. Generation of geometrical phases and persistent spin currents in 1-dimensional rings by Lorentz-violating terms

    Science.gov (United States)

    Casana, R.; Ferreira, M. M.; Mouchrek-Santos, V. E.; Silva, Edilberto O.

    2015-06-01

    We have demonstrated that Lorentz-violating terms stemming from the fermion sector of the SME are able to generate geometrical phases on the wave function of electrons confined in 1-dimensional rings, as well as persistent spin currents, in the total absence of electromagnetic fields. We have explicitly evaluated the eigenenergies and eigenspinors of the electrons modified by the Lorentz-violating terms, using them to calculate the dynamic and the Aharonov-Anandan phases in the sequel. The total phase presents a pattern very similar to the Aharonov-Casher phase accumulated by electrons in rings under the action of the Rashba interaction. Finally, the persistent spin current were carried out and used to impose upper bounds on the Lorentz-violating parameters.

  16. Temporal trends of Persistent Organic Pollutants (POPs) in arctic air: 20 years of monitoring under the Arctic Monitoring and Assessment Programme (AMAP).

    Science.gov (United States)

    Hung, Hayley; Katsoyiannis, Athanasios A; Brorström-Lundén, Eva; Olafsdottir, Kristin; Aas, Wenche; Breivik, Knut; Bohlin-Nizzetto, Pernilla; Sigurdsson, Arni; Hakola, Hannele; Bossi, Rossana; Skov, Henrik; Sverko, Ed; Barresi, Enzo; Fellin, Phil; Wilson, Simon

    2016-10-01

    Temporal trends of Persistent Organic Pollutants (POPs) measured in Arctic air are essential in understanding long-range transport to remote regions and to evaluate the effectiveness of national and international chemical control initiatives, such as the Stockholm Convention (SC) on POPs. Long-term air monitoring of POPs is conducted under the Arctic Monitoring and Assessment Programme (AMAP) at four Arctic stations: Alert, Canada; Stórhöfði, Iceland; Zeppelin, Svalbard; and Pallas, Finland, since the 1990s using high volume air samplers. Temporal trends observed for POPs in Arctic air are summarized in this study. Most POPs listed for control under the SC, e.g. polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethanes (DDTs) and chlordanes, are declining slowly in Arctic air, reflecting the reduction of primary emissions during the last two decades and increasing importance of secondary emissions. Slow declining trends also signifies their persistence and slow degradation under the Arctic environment, such that they are still detectable after being banned for decades in many countries. Some POPs, e.g. hexachlorobenzene (HCB) and lighter PCBs, showed increasing trends at specific locations, which may be attributable to warming in the region and continued primary emissions at source. Polybrominated diphenyl ethers (PBDEs) do not decline in air at Canada's Alert station but are declining in European Arctic air, which may be due to influence of local sources at Alert and the much higher historical usage of PBDEs in North America. Arctic air samples are screened for chemicals of emerging concern to provide information regarding their environmental persistence (P) and long-range transport potential (LRTP), which are important criteria for classification as a POP under SC. The AMAP network provides consistent and comparable air monitoring data of POPs for trend development and acts as a bridge between national monitoring programs and SC's Global Monitoring

  17. A trap-limited-current-based model of Meyer-Neldel rule and its connection to persistent photocurrent

    Science.gov (United States)

    Tian, Ye; Jiang, Lianjun; Zhang, Xuejun; Zhang, Guangfu

    2016-10-01

    A theoretical model is established to describe the emergence of the Meyer-Neldel rule (MNR) based on trap-limited current (TLC) theory. The model produces both MNR and anti-MNR behavior, and is available to various trap distributions. Moreover, TLC-based MNR is connected to persistent photocurrent (PPC) phenomenon. The information from MNR and PPC as well as their connection can be used to probe the distribution of the traps in materials.

  18. Current trends in medical English education and the Japan College of Rheumatology International School.

    Science.gov (United States)

    Jego, Eric Hajime; Amengual, Olga

    2017-04-11

    In light of the present revolution happening in medical education in Japan as medical schools implement new curricula to conform to global standards, there is a growing demand for more internationalization and higher quality practical medical English education. In response, many institutions including governmental organizations, universities and academic associations are moving ahead with new initiatives to adapt to these changing demands. This paper reviews the current trends and innovations in medical English education in Japan. This paper also describes one initiative by the Japan College of Rheumatology (JCR) known as the JCR International School held yearly in Karuizawa. By examining recent trends and innovations in medical English education in Japan, the most relevant and applicable can be elucidated to illuminate a path forward for improved medical English education within the JCR.

  19. Conopressin affects excitability, firing, and action potential shape through stimulation of transient and persistent inward currents in mulluscan neurons.

    Science.gov (United States)

    van Soest, P F; Kits, K S

    1998-04-01

    The molluscan vasopressin/oxytocin-related neuropeptide conopressin activates two persistent inward currents in neurons from the anterior lobe of the right cerebral ganglion of Lymnaea stagnalis that are involved in the control of male copulatory behavior. The low-voltage-activated (LVA) current is activated at a wide range of membrane potentials, its amplitude being only weakly voltage dependent. The high-voltage-activated (HVA) current is activated at potentials positive to -40 mV only and shows a steep voltage dependence. Occurrence of both currents varies from cell to cell, some expressing both and others only the HVA current. In most neurons that have the LVA current, a conopressin-independent persistent inward current (INSR) is found that resembles the HVA current in its voltage dependence. The functional importance of the LVA and HVA currents was studied under current-clamp conditions in isolated anterior lobe neurons. In cells exhibiting both current types, the effect of activation of the LVA current alone was investigated as follows: previously recorded LVA current profiles were injected into the neurons, and the effects were compared with responses induced by conopressin. Both treatments resulted in a strong depolarization and firing activity. No differences in firing frequency and burst duration were observed, indicating that activation of the LVA current is sufficient to evoke bursts. In cells exhibiting only the HVA current, the effect of conopressin on the response to a depolarizing stimulus was tested. Conopressin reversibly increased the number of action potentials generated by the stimulus, suggesting that the HVA current enhances excitability and counteracts accommodation. Conopressin enhanced action potential broadening during depolarizing stimuli in many neurons. Voltage-clamp experiments performed under ion-selective conditions revealed the presence of transient sodium and calcium currents. Using the action potential clamp technique, it was

  20. Current tobacco use trends among Mississippi public high school students: 1993-2009.

    Science.gov (United States)

    Qin, Zhen; Zhang, Lei; Wang, Bo; Hirsch, Erica E; May, Warren; Hart, Roy; Bishop, Melanie; Vargas, Rodolfo L

    2011-01-01

    This study investigates trends in tobacco use based on gender, race, and grade level among Mississippi public high school students during 1993-2009. Data were obtained by combining eight weighted Mississippi Youth Risk Behavior Surveys (YRBS). Current tobacco use (cigarette, smokeless, and cigar) was selected for investigation. During 1993-2009, the prevalence of current cigarette and cigar use among Mississippi public high school students showed a significant linear decrease (p tobacco use. Male students were more likely to be current tobacco users. White students were more likely to use cigarettes and smokeless tobacco. Programs that target male and white students on certain products such as smokeless tobacco are needed to further decrease overall tobacco use in the state.

  1. Research on the Current Telecommuting Trends in United States and European Union Markets

    Directory of Open Access Journals (Sweden)

    Catalina Georgiana PICU

    2016-12-01

    Full Text Available In the context of globalization and due to the accelerated progress made in information and communication technology, more and more companies offer their employees the option of telecommuting. For the past twenty years, telecommuting has been on an asceding trend, an incresing number of people embracing the ability to work from home, using a computer and internet connection to communicate for their jobs. The goal of the paper is to explain the overall notion of telecommuting and to analyze the current trends in the United States and European Union markets. Another objective is to assess the advantages and disadvantages of telecommuting and the important role played by this concept within the striving purpose of corporations to achieve their strategic targets. The study is based upon specialized literature reviews regarding the emergence of telecommuting and the role it plays in organizations. A comparative analysis was conducted by the authors on two regional markets, United States and the European Union, in order to assess the trend in telecommuting and the factors that influence it. The outcome of the research shows that although the benefits of telecommuting are numerous, it does not come without challenges, both being applicable for both the employer, as well as for the employee. The research results of this study can be used by organizations when considering to offer their employees flexible work opportunities which can positively influence the long term business performance.

  2. EDGARv4 Gridded Anthropogenic Emissions of Persistent Organic Pollutants (POPs) from Power Generation, Residential and Transport Sectors: Regional Trends Analysis in East Asia.

    Science.gov (United States)

    Muntean, M.; Janssens-Maenhout, G.; Guizzardi, D.; Crippa, M.; Schaaf, E.; Olivier, J. G.; Dentener, F. J.

    2016-12-01

    Persistent organic pollutants (POPs) are toxic substances and so harmful for human health. Mitigation of these emissions are internationally addressed by the Convention on Long-range Transboundary Air Pollution and by the Stockholm Convention. A global insight on POPs emissions evolution is essential since they can be transported long distances, they bio-accumulate and damage the environment. The Emission Database for Global Atmospheric Research (EDGARv4) is currently updated with POPs. We have estimated the global emissions of Polychlorinated biphenyls (PCBs), Polychlorinated dibenzo-p-dioxins (PCDDs), Polychlorinated dibenzofurans (PCDFs), Polycyclic aromatic hydrocarbons (PAHs) (benzo[a]pyrene (BaP), benzo[b]fluoranthene (BbF), benzo[k]fluoranthene (BkF), Indeno[1,2,3-cd]pyrene (IcdP)) and Hexachlorobenzene (HCB) from fuel combustion in the power generation, residential and transport sectors. This emissions inventory has been developed by using as input to the EDGAR technology-based emissions calculation algorithm the fossil fuel consumption data from International Energy Agency (2014) and the emission factors from EMEP/EEA (2013). We provide a complete emission time series for the period 1970-2010 and discuss the trends. A comprehensive analysis of the contribution of East Asia region to the total global will be provided for each substance of the POPs group. An example is presented in Figure 1 for BaP emissions from residential sector; with emissions mainly from China, the East Asia region has a great share (32%) in the total global. We distributed the POPs emissions on gridmaps of 0.1°x0.1° resolution. Areas with high emissions in East Asia will be presented and discussed; Figure 2 shows the hot-spots in East Asia for BaP emissions from the residential sector. These emission gridmaps, used as input for the chemical transport models, contribute to the improvement of impact evaluation, which is a key element in measuring the effectiveness of mitigation

  3. A BRIEF ANALYSIS OF THE TOURISM SECTOR - CURRENT TRENDS AND ISSUES IN THE BULGARIAN TOURIST BUSINESS

    Directory of Open Access Journals (Sweden)

    Kostadin Valkov

    2016-03-01

    Full Text Available Thе analysis presented in current article deepens and summarizes the results of an economic study focused on the management of human resources in the sector "Tourism". The expected changes in organizational and technological terms are taken into account. The law on tourism in the Republic of Bulgaria and the types of taxes that directly and indirectly affect those employed in tourism are considered. Leading accents are the current trends and issues that arise from the lack of skilled workers in this sector and their deficit caused by the seasonal nature of employment. Growing gray economy is concerned as a major obstacle to development of the tourism industry and its future.

  4. Pricing Data: A Look at Past Proposals, Current Plans, and Future Trends

    CERN Document Server

    Sen, Soumya; Ha, Sangtae; Chiang, Mung

    2012-01-01

    Traditionally, network operators have only used simple flat-rate unlimited data plans to vie for customers. But today, with the popularity of mobile devices and exponential growth of apps, videos, and clouds, service providers are gradually moving towards more sophisticated pricing schemes, including dynamic pricing. This decade will therefore likely witness a major shift in network pricing schemes. However, there are several unique challenges with the dynamic pricing of mobile data, including new system requirements and social adoption. This paper reviews some of the well known past pricing proposals (both static and dynamic), their current realization in various data plans, and new research directions. Unlike a traditional survey, this work is an attempt to explore benefits and challenges of pricing plans that are currently being used by ISPs in different parts of the world so as to facilitate the networking community's efforts in recognizing trends and shaping an appropriate research agenda.

  5. Current Trends in Cloud Computing A Survey of Cloud Computing Systems

    Directory of Open Access Journals (Sweden)

    Harjit Singh

    2012-06-01

    Full Text Available Cloud computing that has become an increasingly important trend, is a virtualization technology that uses the internet and central remote servers to offer the sharing of resources that include infrastructures, software, applications and business processes to the market environment to fulfill the elastic demand. In today’s competitive environment, the service vitality, elasticity, choices and flexibility offered by this scalable technology are too attractive that makes the cloud computing to increasingly becoming an integral part of the enterprise computing environment. This paper presents a survey of the current state of Cloud Computing. It includes a discussion of the evolution process of cloud computing, characteristics of Cloud, current technologies adopted in cloud computing, This paper also presents a comparative study of cloud computing platforms (Amazon, Google and Microsoft, and its challenges.

  6. Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics

    Directory of Open Access Journals (Sweden)

    Dhanasekaran R

    2012-05-01

    Full Text Available Renumathy Dhanasekaran, Alpna Limaye, Roniel CabreraDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, USAAbstract: Hepatocellular carcinoma (HCC is a common malignancy in developing countries and its incidence is on the rise in the developing world. The epidemiology of this cancer is unique since its risk factors, including hepatitis C and B, have been clearly established. The current trends in the shifting incidence of HCC in different regions of the world can be explained partly by the changing prevalence of hepatitis. Early detection offers the only hope for curative treatment for patients with HCC, hence effective screening strategies for high-risk patients is of utmost importance. Liver transplantation and surgical resection remains the cornerstone of curative treatment. But major advances in locoregional therapies and molecular-targeted therapies for the treatment of advanced HCC have occurred recently. In this review, current trends in the worldwide epidemiology, surveillance, diagnosis, standard treatments, and the emerging therapies for HCC are discussed.Keywords: liver cancer, sorafenib, hepatitis C, TACE

  7. Current trends, innovations and issues in nursing education to cater for the bottom billion nurses

    Directory of Open Access Journals (Sweden)

    Pek-Hong Lim

    2012-07-01

    Full Text Available Nurse education is undergoing a processof transition. Nurses worldwide are working towardsachievement of higher levels of education and trainingthrough an improved education system. Current trendsand innovations in nursing education are emerging toprepare more nurses and to deliver education to studentsacross geographical boundaries while taking intoconsideration their work and family responsibilities. Thecurrent trends and innovations in nursing educationrange from full time face-to-face interactions to distanceeducation programmes. Teaching approaches such asblended learning, online or e-Learning have providednurses with an avenue for continuing education fordevelopment and progression in their career pathways.Every nurse aspires to reach her highest potential. Whilethe current trends and innovations in nursing educationprovides the flexibility for nurses to continue learningand upgrade their professional qualifications, there areissues to be considered in catering to the needs of thebottom billion nurses. An exploration of related issueswill include views from different perspectives, such asthat of the institution/provider, instructor/facilitatorand student/learner involved in the development andimplementation of the related education programmes.

  8. Circulating persistent current and induced magnetic field in a fractal network

    Energy Technology Data Exchange (ETDEWEB)

    Saha, Srilekha [Condensed Matter Physics Division, Saha Institute of Nuclear Physics, Sector-I, Block-AF, Bidhannagar, Kolkata 700 064 (India); Maiti, Santanu K., E-mail: santanu.maiti@isical.ac.in [Physics and Applied Mathematics Unit, Indian Statistical Institute, 203 Barrackpore Trunk Road, Kolkata 700 108 (India); Karmakar, S.N. [Condensed Matter Physics Division, Saha Institute of Nuclear Physics, Sector-I, Block-AF, Bidhannagar, Kolkata 700 064 (India)

    2016-04-29

    We present the overall conductance as well as the circulating currents in individual loops of a Sierpinski gasket (SPG) as we apply bias voltage via the side attached electrodes. SPG being a self-similar structure, its manifestation on loop currents and magnetic fields is examined in various generations of this fractal and it has been observed that for a given configuration of the electrodes, the physical quantities exhibit certain regularity as we go from one generation to another. Also a notable feature is the introduction of anisotropy in hopping causes an increase in magnitude of overall transport current. These features are a subject of interest in this article. - Highlights: • Voltage driven circular current is analyzed in a fractal network. • Current induced magnetic field is strong enough to flip a spin. • Anisotropy in hopping enhances overall transport current.

  9. Persistent Spin Current in a Quantum Wire with Weak Rashba Spin-Orbit Coupling

    Institute of Scientific and Technical Information of China (English)

    WANG Yi; SHENG Wei; ZHOU Guang-Hui

    2006-01-01

    @@ We theoretically investigate the spin current for a parabolically confined semiconductor heterojunction quantum wire with weak Rashba spin-orbit coupling by means of the perturbation method. By analytical calculation, it is found that only two components off spin current density is non-zero in the equilibrium case. Numerical examples have demonstrated that the spin current of electron transverse motion is 10-3 times that off electron longitudinal motion. However, the former one is much more sensitive to the strength of Rashba spin-orbit coupling. These results may suggest an approach to the spin storage device and to the measurement of spin current through its induced electric field.

  10. Persistent spin current in a quantum wire with weak Dresselhaus spin-orbit coupling

    Institute of Scientific and Technical Information of China (English)

    Sheng Wei; Wang Yi; Zhou Guang-Hui

    2007-01-01

    The spin current in a parabolically confined semiconductor heterojunction quantum wire with Dresselhaus spinorbit coupling is theoretically studied by using the perturbation method. The formulae of the elements for linear and angular spin current densities are derived by using the recent definition for spin current based on spin continuity equation. It is found that the spin current in this Dresselhaus spin-orbit coupling quantum wire is antisymmetrical,which is different from that in R ashba model due to the difference in symmetry between these two models. Some numerical examples for the result are also demonstrated and discussed.

  11. A Conceptual Analysis of Current Trends in the Evolution of Risk Management Process

    Directory of Open Access Journals (Sweden)

    Monika Wieczorek-Kosmala

    2013-11-01

    Full Text Available Purpose of the article: The traditional idea of risk management is continually evolving as it enjoys growing popularity in corporations. The paper reviews the risk management procedure within the traditional concept and then identifies and discusses the main trends currently observed within the organisation and implementation of this procedure. Scientific aim: The paper aims at identyfing and describing the currently observed trends in the evolution of risk management process. To achieve this, it aims at comparative analysis of solutions within traditional risk management concept and the ideas underpinning the current process of risk management standardisation. It also aims at reviewing the validity of clasiffication of risk treatment techniques. Methodology/methods: The paper represents a conceptual analysis of the current state of affairs and uses the method of comparative analysis and deduction based on the literature review and the lecture of standardisation documents. As a viewpoint paper, it represents au-thor’s own ideas and findings. Findings: The two main trends of risk management evolution should be idetified. The first one is related with strategic dimension of risk management as this procedure is often promoted as an integrated concept. It springs from the regulations of standardisation procedures which aim at unifying the terminology and set of activities from practitioners’ perspective. The second direction of risk management concept evolution is observed within the development of risk financing techniques due to the innovations observed within traditional risk retention and trasfer solutions, as a result of continuous convergence of insurance and capital markets. Conclusions: (limits, implications etc The risk management process is constantly evolving toward the strategic dimension as the risk perception changes, concerning both the downside and upside of risk. However, the standards follow similar sequence of

  12. Contrasting Effects of the Persistent Na + Current on Neuronal Excitability and Spike Timing

    National Research Council Canada - National Science Library

    Vervaeke, Koen; Hu, Hua; Graham, Lyle J; Storm, Johan F

    2006-01-01

    .... Using computational modeling, whole-cell recording, and dynamic clamp of CA1 hippocampal pyramidal cells in brain slices, we examined how INaP changes the transduction of excitatory current into action potentials...

  13. Future trends in soil cadmium concentration under current cadmium fluxes to European agricultural soils.

    Science.gov (United States)

    Six, L; Smolders, E

    2014-07-01

    The gradual increase of soil cadmium concentrations in European soils during the 20th century has prompted environmental legislation to limit soil cadmium (Cd) accumulation. Mass balances (input-output) reflecting the period 1980-1995 predicted larger Cd inputs via phosphate (P) fertilizers and atmospheric deposition than outputs via crop uptake and leaching. This study updates the Cd mass balance for the agricultural top soils of EU-27+Norway (EU-27+1). Over the past 15 years, the use of P fertilizers in the EU-27+1 has decreased by 40%. The current mean atmospheric deposition of Cd in EU is 0.35 g Cd ha(-1) yr(-1), this is strikingly smaller than values used in the previous EU mass balances (~3 g Cd ha(-1) yr(-1)). Leaching of Cd was estimated with most recent data of soil solution Cd concentrations in 151 soils, which cover the range of European soil properties. No significant time trends were found in the data of net applications of Cd via manure, compost, sludge and lime, all being small sources of Cd at a large scale. Modelling of the future long-term changes in soil Cd concentrations in agricultural top soils under cereal or potato culture predicts soil Cd concentrations to decrease by 15% over the next 100 years in an average scenario, with decreasing trends in some scenarios being more prevalent than increasing trends in other scenarios. These Cd balances have reverted from the general positive balances estimated 10 or more years ago. Uncertainty analysis suggests that leaching is the most uncertain relative to other fluxes.

  14. Climate change and plankton phenology in freshwater: current trends and future commitments

    Directory of Open Access Journals (Sweden)

    Csaba Vadadi-Fülöp

    2014-01-01

    Full Text Available A solid body of empirical, experimental and theoretical evidence accumulated over recent years indicated that freshwater plankton experienced advance in phenology in response to climate change. Despite rapidly growing evidence for phenological changes, we still lack a comprehensive understanding of how climate change alters plankton phenology in freshwater. To overcome current limitations, we need to shed some light on trends and constraints in current research. The goal of this study is to identify current trends and gaps based on analysis of selected papers, by the help of which we can facilitate further advance in the field. We searched the literature for plankton phenology and confined our search to studies where climate change has been proposed to alter plankton phenology and rates of changes were quantified. We did not restrict our search for empirical contributions; experimental and theoretical studies were considered as well. In the following we discuss the spatio-temporal setting of selected studies, contributions of different taxonomic groups, emerging methodological constraints, measures of phenological trends; and finally give a list of recommendations on how to improve our understanding in the field. The majority of studies were confined to deep lakes with a skewed geographical distribution toward Central Europe, where scientists have long been engaged in limnology. Despite these findings, recent studies suggest that plankton in running waters may experience change in phenology with similar magnitude. Average rate of advancement in phenology of freshwater plankton exceeded those of the marine plankton and the global average. Increasing study duration was not coupled either with increasing contribution of discontinuous data or with increasing rates of phenological changes. Future studies may benefit from i delivering longterm data across scientific and political boundaries; ii extending study sites to broader geographical areas with

  15. [Lead exposure in the ceramic tile industry: time trends and current exposure levels].

    Science.gov (United States)

    Candela, S; Ferri, F; Olmi, M

    1998-01-01

    There is a high density of industries for the production of ceramic tiles in the District of Scandiano (province of Reggio Emilia, Emilia Romagna region). In this area, since the beginning of 1970s, the time trend of Pb exposure in ceramic tile plants has been evaluated by means of biological monitoring (BM) data collected at the Service of Prevention and Safety in the Work Environment and its associated Toxicology Laboratory. From these data, a clear decreasing time trend of exposure levels is documented, the reduction being more evident during the seventies and in 1985-88. During the seventies BM was introduced systematically in all ceramic tile plants with the determination of delta-aminolevulinic acid in urine (ALA-U). As a consequence of the BM programme, hygienic measures for the abatement of pollution inside the plants were implemented, and a reduction, from 20.6% to 2%, of ALA-U values exceeding 10 mg/l, was observed. In 1985, the determination of lead in blood (PbB) replaced that of ALA-U in the BM programmes and highlighted the persistence of high level of exposure to Pb, which could not be outlined by means of ALA-U because of its lower sensitivity. PbB levels were 36.1 micrograms/100 ml and 25.7 micrograms/100 ml in male and female workers, respectively. These results required the implementation, within the plants, of additional hygienic measures and a significant reduction of PbB was obtained in the following three years. In 1988 PbB levels were 26.0 +/- 10.7 and 21.6 +/- 10.3 micrograms/100 ml in male and female workers, respectively. In 1993-95 Pb levels were obtained from 1328 male and 771 female workers of 56 plants, accounting for about 40% of the total number of workers in the ceramic industry, in the zones of Sassuolo and Scandiano. Exposure levels are not different from those observed in the preceding years, with PbB levels of 25.3 +/- 11.1 and 19.1 +/- 9.2 micrograms/100 ml in male and female workers, respectively.

  16. Current trends in treatment of obesity in Karachi and possibilities of cost minimization.

    Science.gov (United States)

    Hussain, Mirza Izhar; Naqvi, Baqir Shyum

    2015-03-01

    Our study finds out drug usage trends in over weight and obese patients without any compelling indications in Karachi, looks for deviations of current practices from evidence based antihypertensive therapeutic guidelines and identifies not only cost minimization opportunities but also communication strategies to improve patients' awareness and compliance to achieve therapeutic goal. In present study two sets were used. Randomized stratified independent surveys were conducted in hospital doctors and family physicians (general practitioners), using pretested questionnaires. Sample size was 100. Statistical analysis was conducted on Statistical Package for Social Science (SPSS). Opportunities of cost minimization were also analyzed. One the basis of doctors' feedback, preference is given to non-pharmacologic management of obesity. Mass media campaign and media usage were recommended to increase patients awareness and patients' education along with strengthening family support systems was recommended for better compliance of the patients to doctor's advice. Local therapeutic guidelines for weight reduction were not found. Feedbacks showed that global therapeutic guidelines were followed by the doctors practicing in the community and hospitals in Karachi. However, high price branded drugs were used instead of low priced generic therapeutic equivalents. Patient's education is required for better awareness and improving patients' compliance. The doctors found preferring brand leaders instead of low cost options. This trend increases cost of therapy by 0.59 to 4.17 times. Therefore, there are great opportunities for cost minimization by using evidence-based clinically effective and safe medicines.

  17. Current trend in drug delivery considerations for subcutaneous insulin depots to treat diabetes.

    Science.gov (United States)

    P V, Jayakrishnapillai; Nair, Shantikumar V; Kamalasanan, Kaladhar

    2017-05-01

    Diabetes mellitus (DM) is a metabolic disorder due to irregularities in glucose metabolism, as a result of insulin disregulation. Chronic DM (Type 1) is treated by daily insulin injections by subcutaneous route. Daily injections cause serious patient non-compliance and medication non-adherence. Insulin Depots (ID) are parenteral formulations designed to release the insulin over a specified period of time, to control the plasma blood glucose level for intended duration. Physiologically, pancreas produces and secretes insulin in basal and pulsatile mode into the blood. Delivery systems mimicking basal release profiles are known as open-loop systems and current marketed products are open-loop systems. Future trend in open-loop systems is to reduce the number of injections per week by enhancing duration of action, by modifying the depot properties. The next generation technologies are closed-loop systems that mimic the pulsatile mode of delivery by pancreas. In closed-loop systems insulin will be released in response to plasma glucose. This review focuses on future trend in open-loop systems; by understanding (a) the secretion of insulin from pancreas, (b) the insulin regulation normal and in DM, (c) insulin depots and (d) the recent progress in open-loop depot technology particularly with respect to nanosystems. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. DEVELOPMENT OF ACCELERATOR DATA REPORTING SYSTEM AND ITS APPLICATION TO TREND ANALYSIS OF BEAM CURRENT DATA

    Energy Technology Data Exchange (ETDEWEB)

    Padilla, M.J.; Blokland, W.

    2009-01-01

    Detailed ongoing information about the ion beam quality is crucial to the successful operation of the Spallation Neutron Source at Oak Ridge National Laboratory. In order to provide the highest possible neutron production time, ion beam quality is monitored to isolate possible problems or performance-related issues throughout the accelerator and accumulator ring. For example, beam current monitor (BCM) data is used to determine the quality of the beam transport through the accelerator. In this study, a reporting system infrastructure was implemented and used to generate a trend analysis report of the BCM data. The BCM data was analyzed to facilitate the identifi cation of monitor calibration issues, beam trends, beam abnormalities, beam deviations and overall beam quality. A comparison between transformed BCM report data and accelerator log entries shows promising results which represent correlations between the data and changes made within the accelerator. The BCM analysis report is one of many reports within a system that assist in providing overall beam quality information to facilitate successful beam operation. In future reports, additional data manipulation functions and analysis can be implemented and applied. Built-in and user-defi ned analytic functions are available throughout the reporting system and can be reused with new data.

  19. Comprehensive management of pressure ulcers in spinal cord injury: Current concepts and future trends

    Science.gov (United States)

    Kruger, Erwin A.; Pires, Marilyn; Ngann, Yvette; Sterling, Michelle; Rubayi, Salah

    2013-01-01

    Pressure ulcers in spinal cord injury represent a challenging problem for patients, their caregivers, and their physicians. They often lead to recurrent hospitalizations, multiple surgeries, and potentially devastating complications. They present a significant cost to the healthcare system, they require a multidisciplinary team approach to manage well, and outcomes directly depend on patients' education, prevention, and compliance with conservative and surgical protocols. With so many factors involved in the successful treatment of pressure ulcers, an update on their comprehensive management in spinal cord injury is warranted. Current concepts of local wound care, surgical options, as well as future trends from the latest wound healing research are reviewed to aid medical professionals in treating patients with this difficult problem. PMID:24090179

  20. End-of-Life Care and Psychiatry: Current Trends and Future Directions in India

    Directory of Open Access Journals (Sweden)

    Jayita K Deodhar

    2016-01-01

    Full Text Available Although 80% of the deaths worldwide occur in middle- and low-income countries such as India, there is less awareness of end-of-life care (EOLC for people with chronic, serious, progressive, or advanced life-limiting illnesses, including dementia. EOLC involves good communication, clinical decision-making, liaison with medical teams and families, comprehensive assessment of and specialized interventions for physical, psychological, spiritual, and social needs of patients and their caregivers. The psychiatrist can play a significant role in each of the above domains in EOLC. The current trends in India are examined, including ambiguities between EOLC and euthanasia. Future directions include formulating a national EOLC policy, providing appropriate services and training. The psychiatrist should get involved in this process, with major responsibilities in providing good quality EOLC for patients with both life-limiting physical illnesses and severe mental disorders, supporting their caregivers, and ensuring dignity in death.

  1. End-of-Life Care and Psychiatry: Current Trends and Future Directions in India.

    Science.gov (United States)

    Deodhar, Jayita K

    2016-01-01

    Although 80% of the deaths worldwide occur in middle- and low-income countries such as India, there is less awareness of end-of-life care (EOLC) for people with chronic, serious, progressive, or advanced life-limiting illnesses, including dementia. EOLC involves good communication, clinical decision-making, liaison with medical teams and families, comprehensive assessment of and specialized interventions for physical, psychological, spiritual, and social needs of patients and their caregivers. The psychiatrist can play a significant role in each of the above domains in EOLC. The current trends in India are examined, including ambiguities between EOLC and euthanasia. Future directions include formulating a national EOLC policy, providing appropriate services and training. The psychiatrist should get involved in this process, with major responsibilities in providing good quality EOLC for patients with both life-limiting physical illnesses and severe mental disorders, supporting their caregivers, and ensuring dignity in death.

  2. Metacognition fundaments, applications, and trends a profile of the current state-of-the-art

    CERN Document Server

    2015-01-01

    This book is devoted to the Metacognition arena. It highlights works that show relevant analysis, reviews, theoretical, and methodological proposals, as well as studies, approaches, applications, and tools that shape current state, define trends and inspire future research. As a result of the revision process fourteen manuscripts were accepted and organized into five parts as follows: ·     Conceptual: contains conceptual works oriented to: (1) review models of strategy instruction and tailor a hybrid strategy; (2) unveil second-order judgments and define a method to assess metacognitive judgments; (3) introduces a conceptual model to describe the metacognitive activity as an autopoietic system. ·     Framework: offers three works concerned with: (4) stimulate metacognitive skills and self-regulatory functions; (5) evaluate metacognitive skills and self-regulated learning at problem solving; (6) deal with executive management metacognition and strategic knowledge metacognition. ·     Studies: r...

  3. A survey of current trends in diffusion MRI for structural brain connectivity

    Science.gov (United States)

    Ghosh, Aurobrata; Deriche, Rachid

    2016-02-01

    In this paper, we review the state of the art in diffusion magnetic resonance imaging (dMRI) and we present current trends in modelling the brain's tissue microstructure and the human connectome. dMRI is today the only tool that can probe the brain's axonal architecture in vivo and non-invasively, and has grown in leaps and bounds in the last two decades since its conception. A plethora of models with increasing complexity and better accuracy have been proposed to characterise the integrity of the cerebral tissue, to understand its microstructure and to infer its connectivity. Here, we discuss a wide range of the most popular, important and well-established local microstructure models and biomarkers that have been proposed from these models. Finally, we briefly present the state of the art in tractography techniques that allow us to understand the architecture of the brain's connectivity.

  4. Modulation of inhibitory strength and kinetics facilitates regulation of persistent inward currents and motoneuron excitability following spinal cord injury.

    Science.gov (United States)

    Venugopal, Sharmila; Hamm, Thomas M; Crook, Sharon M; Jung, Ranu

    2011-11-01

    Spasticity is commonly observed after chronic spinal cord injury (SCI) and many other central nervous system disorders (e.g., multiple sclerosis, stroke). SCI-induced spasticity has been associated with motoneuron hyperexcitability partly due to enhanced activation of intrinsic persistent inward currents (PICs). Disrupted spinal inhibitory mechanisms also have been implicated. Altered inhibition can result from complex changes in the strength, kinetics, and reversal potential (E(Cl(-))) of γ-aminobutyric acid A (GABA(A)) and glycine receptor currents. Development of optimal therapeutic strategies requires an understanding of the impact of these interacting factors on motoneuron excitability. We employed computational methods to study the effects of conductance, kinetics, and E(Cl(-)) of a dendritic inhibition on PIC activation and motoneuron discharge. A two-compartment motoneuron with enhanced PICs characteristic of SCI and receiving recurrent inhibition from Renshaw cells was utilized in these simulations. This dendritic inhibition regulated PIC onset and offset and exerted its strongest effects at motoneuron recruitment and in the secondary range of the current-frequency relationship during PIC activation. Increasing inhibitory conductance compensated for moderate depolarizing shifts in E(Cl(-)) by limiting PIC activation and self-sustained firing. Furthermore, GABA(A) currents exerted greater control on PIC activation than glycinergic currents, an effect attributable to their slower kinetics. These results suggest that modulation of the strength and kinetics of GABA(A) currents could provide treatment strategies for uncontrollable spasms.

  5. Space Robotics: Current Status, Long-term Objectives, and Development Trends. Analytical Review

    Directory of Open Access Journals (Sweden)

    P. P. Belonozhko

    2016-01-01

    Full Text Available Prospects for space robotics concern both the development of used prototypes to extend the capabilities and the creation of new classes of systems, the operating analogues of which are, currently, unavailable. Thus, a uniqueness of the objects of space robotics, extreme operating conditions, difficulty in full-scale ground work and tests define a variety of design solutions and a wide scope of issues for further theoretical and experimental studies. The paper highlights the tasks successfully solved up to date, involving the space robotics equipment that was used in orbital environment, those of currently solved, involving the robotics equipment that is in use, and the long-term objectives, following from the logic of the space technology development to define the ways of its further development and require a development and creation of new equipment of space robotics. Thus, the development trends of space robotics are largely defined by its history of development, on the one hand, and by a growing demand for the robotic service as applied to the promising objects of space technology, on the other one. The paper considers the trends of space robotics development, which are a consequence of the natural logic of its development and are determined by a demand for advanced objects of space technology in robotic servicing. Highlights the most important elements of a design concept and the creating and operating features of the multipurpose extendable space systems, including those, which have no analogues and prototypes, are rolled into one demand for automation, and associated with their creation, operation, and problems of utilization. The concept of assembly and service autonomous robotic space modules has been under consideration. Within the orbital assembly procedure, the typical dynamic modes, relevant in terms of practical implementation of controlled movement are highlighted.

  6. Review: Current trends in coral transplantation – an approach to preserve biodiversity

    Directory of Open Access Journals (Sweden)

    ABDELNABY ORABI

    2013-04-01

    Full Text Available Ammar MSA,El-Gammal F, Nassar M, Belal A, Farag W, El-Mesiry G, El-Haddad K, Orabi A, Abdelreheem A, Shaaban A. 2013. Review: Current trends in coral transplantation – an approach to preserve biodiversity. Biodiversitas 14: 43-53. The increasing rates of coral mortality associated with the rise in stress factors and the lack of adequate recovery worldwide have urged recent calls for actions by the scientific, conservation, and reef management communities. This work reviews the current trends in coral transplantation. Transplantation of coral colonies or fragments, whether from aqua-, mariculture or harvesting from a healthy colony, has been the most frequently recommended action for increasing coral abundance on damaged or degraded reefs and for conserving listed or “at-risk” species. Phytoplanktons are important for providing transplanted corals with complex organic compounds through photosynthesis. Artificial surfaces like concrete blocks, wrecks or other purpose-designed structures can be introduced for larval settlement. New surfaces can also be created through electrolysis. Molecular biological tools can be used to select sites for rehabilitation by asexual recruits. Surface chemistry and possible inputs of toxic leachate from artificial substrates are considered as important factors affecting natural recruitment. Transplants should be carefully maintained , revisited and reattached at least weekly in the first month and at least fortnightly in the next three months. Studies on survivorship and the reproductive ability of transplanted coral fragments are important for coral reef restoration. A coral nursery may be considered as a pool for local species that supplies reef-managers with unlimited coral colonies for sustainable management. Transplanting corals for making artificial reefs can be useful for increasing biodiversity, providing tourist diving, fishing and surfing; creating new artisanal and commercial fishing opportunities

  7. Compensation of the Persistent Current Multipoles in the LHC Dipoles by making the Coil Protection Sheet from Soft Magnetic Material

    CERN Document Server

    Völlinger, C

    2000-01-01

    This note presents a scheme for compensating the persistent current multipole errors of the LHC dipoles by making the coil protection sheets from soft magnetic material of 0.5 mm thickness. The material properties assumed in this study are those of iron sheets with a very low content of impurities (99.99% pure Fe). The non-linearities in the upramp cycle on the b3 multipole component can be reduced by the factor of four (while decreasing the b5 variation by the factor of two. Using sheets of slightly different thicknesses offers a tuning possibility for the series magnet coils and can compensate deviations arising from cables of different suppliers. The calculation method is based on a semi-analytical hysteresis model for hard superconductors and an M(B) - iteration using the method of coupled boundary elements - finite elements (BEM - FEM). It is now possible to compute persistent current multipole errors of geometries with arbitrarily shaped iron yokes and thin layers of soft magnetic material such as tunin...

  8. A computational investigation of cardiac caveolae as a source of persistent sodium current

    Directory of Open Access Journals (Sweden)

    Ian M. Besse

    2011-11-01

    Full Text Available Recent studies of cholesterol-rich membrane microdomains, called caveolae, reveal that caveolae are reservoirs of recruitable sodium ion channels. Caveolar channels constitute a substantial and previously unrecognized source of sodium current in cardiac cells. In this paper we model for the first time caveolar sodium currents and their contributions to cardiac action potential morphology. We show that the beta-agonist-induced opening of caveolae may have substantial impacts on peak overshoot, maximum upstroke velocity, and ultimately conduction velocity. Additionally, we show that prolonged action potentials and the formation of potentially arrhythmogenic afterdepolarizations, can arise if caveolae open intermittently throughout the action potential. Our simulations suggest that there may exist routes to delayed repolarization, and the arrhythmias associated with such delays, that are independent of channelopathies.

  9. A persistent sodium current contributes to oscillatory activity in heart interneurons of the medicinal leech.

    Science.gov (United States)

    Opdyke, C A; Calabrese, R L

    1994-12-01

    1. Normal activity in bilateral pairs of heart interneurons, from ganglia 3 or 4, in the medicinal leech (Hirudo medicinalis) is antiphasic due to their reciprocally inhibitory connections. However, Ca(++)-free Co(++)-containing salines lead to synchronous oscillations in these neurons. 2. Internal TEA+ allows expression of full plateaus during Co++ induced oscillations in heart interneurons; these plateaus are not blocked by Cs+. Similar plateaus are also observed with internal TEA+ alone, but under these conditions activity in heart interneurons from ganglia 3 or 4 is antiphasic. 3. Plateaus in heart interneurons induced by Co++ and internal TEA+ involve a conductance increase. 4. A voltage-dependent inward current, IP, showing little inactivation, was isolated using single-electrode voltage-clamp in heart interneurons. This current is carried at least in part by Na+; the current is reduced when external Na+ is reduced and is carried by Li++ when substituted for Na+. 5. Calcium channel blockers such as La3+ and Co++ block neither the TEA+ induced plateaus nor IP, suggesting that Na+ is not using Ca++ channels. Moreover, IP is enhanced by Ca(++)-free CO(++)-containing salines. Thus, IP is correlated with the TEA(+)- and Co(++)-induced plateau behavior.

  10. Current Trends in the Management of Phyllodes Tumors of the Breast

    Science.gov (United States)

    Adesoye, Taiwo; Neuman, Heather B; Wilke, Lee G; Schumacher, Jessica R; Steiman, Jennifer; Greenberg, Caprice C

    2016-01-01

    Introduction National Comprehensive Cancer Network (NCCN) guidelines recommend wide excision without axillary staging to treat phyllodes tumors of the breast. Without prospective trials to guide management, NCCN also recommends consideration of radiation therapy (XRT). We describe current patterns of care for the multidisciplinary management of phyllodes tumors. Methods Using Surveillance, Epidemiology and End Results Program (SEER) data, we identified women diagnosed with phyllodes tumors between 2000 and 2012 who underwent surgical therapy. Trends in breast conserving surgery (BCS), nodal sampling and XRT were assessed using the Cochrane-Armitage test. Multivariable logistic regression was used to identify factors associated with treatment. Results Of 1,238 patients, 56.9% underwent BCS and 23.6% underwent nodal sampling (10.5% after BCS vs 40.9% after mastectomy). After surgery, 15.4% received adjuvant XRT (BCS, 12.9% and mastectomy, 18.8%). XRT utilization increased significantly over the study period (BCS, p=tumors. Nodal sampling was also associated with older age, larger tumor size and receipt of mastectomy. Receipt of XRT was associated with later year of diagnosis, larger tumors and nodal assessment. Conclusion Over time, an increasing number of women received XRT after surgical management of phyllodes tumor, and one in four women underwent nodal sampling. While some of this practice can be attributed to concern about more advanced disease in the absence of strong data, there may be an educational gap regarding current guidelines and appropriate management. PMID:27334214

  11. The distribution of pharmaceuticals in Europe--current and future trends in wholesaling.

    Science.gov (United States)

    Andersson, F

    1994-03-01

    As of January 1, 1993 a huge market, encompassing more than 325 million people, has been established with the unification of the 12 member states in the European Community. During the last 10 years, the pharmaceutical wholesaling sector has therefore been involved in an intense restructuring process. But, there is a considerable scientific gap in the knowledge of pharmaceutical wholesaling. In view of the uncertain situation and the scarcity of structured information, the purpose of this article is to examine current and future trends in the European pharmaceutical wholesaling sector. We reviewed the literature and identified three major areas of interest; general threats to traditional full-line wholesaling, wholesalers' response to these threats, and the new Glaxo distribution scheme. The current and expected importance of these areas were assessed with the help of a survey, encompassing 20 experts in this field. Based on the review and the survey, we conclude that there are many serious threats to traditional wholesaling, the major ones being governmental pressures to lower the already relatively low gross margins, manufacturers contemplating taking over the drug distribution process themselves and increasing international competition. The major responses to these threats are to become a truly international player (via mergers, acquisitions and joint ventures), or being able to provide the customers with detailed management information through computerised networks. In order to survive the next 5-10 years, companies have to be very alert to the changing competitive situation.

  12. Current status and trends in oral health in community dwelling older adults: a global perspective.

    Science.gov (United States)

    Kossioni, Anastassia E

    2013-01-01

    To record the available current national and regional data on the oral health of community-dwelling (living in their own homes, not institutionalised) older people globally and discuss the future trends considering existing dangers and opportunities. A literature search on tooth loss, dental decay and periodontal disease in the elderly was performed using available databases and electronic sources. The findings revealed that the updated national data are scarce in many parts of the world, particularly in Africa, Asia and South America, and direct comparisons are not always possible due to methodological variations. The available information may indicate that dental disease in older adults worldwide is more prevalent compared to younger age groups, with significant variation between countries and regions. Tooth loss is currently more common in the developed countries, while dental decay and periodontal disease are more widespread globally. There are important threats for further deterioration of the oral status among older adults in many developed and less developed areas due to existing sociodemographic and economic risk factors. National studies should be undertaken to record the specific oral problems of the elderly in each area. It is also necessary to develop gerodontology study programmes globally at the undergraduate, postgraduate and continuing education levels which will enhance dentists' knowledge, skills and attitudes towards oral care in the older population, and will promote opportunities for further research and development of relevant policies.

  13. Current trends in endotoxin detection and analysis of endotoxin-protein interactions.

    Science.gov (United States)

    Dullah, Elvina Clarie; Ongkudon, Clarence M

    2017-03-01

    Endotoxin is a type of pyrogen that can be found in Gram-negative bacteria. Endotoxin can form a stable interaction with other biomolecules thus making its removal difficult especially during the production of biopharmaceutical drugs. The prevention of endotoxins from contaminating biopharmaceutical products is paramount as endotoxin contamination, even in small quantities, can result in fever, inflammation, sepsis, tissue damage and even lead to death. Highly sensitive and accurate detection of endotoxins are keys in the development of biopharmaceutical products derived from Gram-negative bacteria. It will facilitate the study of the intermolecular interaction of an endotoxin with other biomolecules, hence the selection of appropriate endotoxin removal strategies. Currently, most researchers rely on the conventional LAL-based endotoxin detection method. However, new methods have been and are being developed to overcome the problems associated with the LAL-based method. This review paper highlights the current research trends in endotoxin detection from conventional methods to newly developed biosensors. Additionally, it also provides an overview of the use of electron microscopy, dynamic light scattering (DLS), fluorescence resonance energy transfer (FRET) and docking programs in the endotoxin-protein analysis.

  14. Radiology Research in Quality and Safety: Current Trends and Future Needs.

    Science.gov (United States)

    Zygmont, Matthew E; Itri, Jason N; Rosenkrantz, Andrew B; Duong, Phuong-Anh T; Mankowski Gettle, Lori; Mendiratta-Lala, Mishal; Scali, Elena P; Winokur, Ronald S; Probyn, Linda; Kung, Justin W; Bakow, Eric; Kadom, Nadja

    2017-03-01

    Promoting quality and safety research is now essential for radiology as reimbursement is increasingly tied to measures of quality, patient safety, efficiency, and appropriateness of imaging. This article provides an overview of key features necessary to promote successful quality improvement efforts in radiology. Emphasis is given to current trends and future opportunities for directing research. Establishing and maintaining a culture of safety is paramount to organizations wishing to improve patient care. The correct culture must be in place to support quality initiatives and create accountability for patient care. Focused educational curricula are necessary to teach quality and safety-related skills and behaviors to trainees, staff members, and physicians. The increasingly complex healthcare landscape requires that organizations build effective data infrastructures to support quality and safety research. Incident reporting systems designed specifically for medical imaging will benefit quality improvement initiatives by identifying and learning from system errors, enhancing knowledge about safety, and creating safer systems through the implementation of standardized practices and standards. Finally, validated performance measures must be developed to accurately reflect the value of the care we provide for our patients and referring providers. Common metrics used in radiology are reviewed with focus on current and future opportunities for investigation. Copyright © 2017 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  15. Future Performance Trend Indicators: A Current Value Approach to Human Resources Accounting. Report V: The Value Attribution Process. Technical Report.

    Science.gov (United States)

    Lapointe, Jean B.; And Others

    The development of future performance trend indicators is based on the current value approach to human resource accounting. The value attribution portion of the current value approach is used to estimate the dollar value of observed changes in the state of the human organization. The procedure for value attribution includes: prediction of changes…

  16. Persistent current oscillations produced by activation of metabotropic glutamate receptors in immature rat CA3 hippocampal neurons.

    Science.gov (United States)

    Aniksztejn, L; Sciancalepore, M; Ben Ari, Y; Cherubini, E

    1995-04-01

    1. The single-electrode voltage-clamp technique was used to study the effects of the metabotropic glutamate receptors (mGluRs) agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD, ACPD, 3-10 microM) on CA3 hippocampal neurons during the 1st 10 days of postnatal (P) life and in adulthood. 2. Repeated applications of 1S,3R-ACPD, in the presence of tetrodotoxin (TTX, 1 microM), tetraethylammonium chloride (TEACl 10 mM), and CsCl (2 mM), induced in immature but not in adult neurons periodic inward currents (PICs) that persisted for several hours after the last application of the agonist. 3. PICs, which were generated by nonspecific cationic currents, reversed polarity at 2.8 +/- 3 (SD) mV. They were reversibly blocked by kynurenic acid (1 mM), suggesting that they were mediated by glutamate acting on ionotropic receptors. They were also abolished in a nominally Ca(2+)-free medium. 4. PICs were irreversibly abolished by thapsigargin (10 microM) but were unaffected by ryanodine (10-40 microM). Caffeine (2 mM) also reversibly blocked PICs; this effect was independent from adenosine 3',5'-cyclic monophosphate (cAMP) accumulation, inhibition of voltage-dependent Ca2+ current, or blockade of adenosine receptors. 5. We suggest that, in neonatal slices, mGluRs-induced PICs are triggered by elevation of [Ca2+]i, after mobilization of Ca2+ from inositol 1,4,5-trisphosphate (InsP3)-sensitive stores. This will lead to a persistent, pulsatile release of glutamate from presynaptic nerve terminals, a phenomenon that is probably maintained via a calcium-induced-calcium release process.

  17. Current issues in patient adherence and persistence: focus on anticoagulants for the treatment and prevention of thromboembolism

    Directory of Open Access Journals (Sweden)

    Patrick P Kneeland

    2010-03-01

    Full Text Available Patrick P Kneeland, Margaret C FangThe University of California, San Francisco Division of Hospital Medicine, San Francisco, CA, USAAbstract: Warfarin therapy reduces morbidity and mortality related to thromboembolism. Yet adherence to long-term warfarin therapy remains challenging due to the risks of anticoagulantassociated complications and the burden of monitoring. The aim of this paper is to review determinants of adherence and persistence on long-term anticoagulant therapy for atrial fibrillation and venous thromboembolism. We evaluate what the current literature reveals about the impact of warfarin on quality of life, examine warfarin trial data for patterns of adherence, and summarize known risk factors for warfarin discontinuation. Studies suggest only modest adverse effects of warfarin on quality of life, but highlight the variability of individual lifestyle experiences of patients on warfarin. Interestingly, clinical trials comparing anticoagulant adherence to alternatives (such as aspirin show that discontinuation rates on warfarin are not consistently higher than in control arms. Observational studies link a number of risk factors to warfarin non-adherence including younger age, male sex, lower stroke risk, poor cognitive function, poverty, and higher educational attainment. In addition to differentiating the relative impact of warfarin-associated complications (such as bleeding versus the lifestyle burdens of warfarin monitoring on adherence, future investigation should focus on optimizing patient education and enhancing models of physician–patient shared-decision making around anticoagulation.Keywords: anticoagulation, warfarin, adherence, persistence, thromboembolism

  18. Dynamic and energetic stabilization of persistent currents in Bose-Einstein condensates

    KAUST Repository

    Law, K. J. H.

    2014-05-09

    We study conditions under which vortices in a highly oblate harmonically trapped Bose-Einstein condensate (BEC) can be stabilized due to pinning by a blue-detuned Gaussian laser beam, with particular emphasis on the potentially destabilizing effects of laser beam positioning within the BEC. Our approach involves theoretical and numerical exploration of dynamically and energetically stable pinning of vortices with winding number up to S=6, in correspondence with experimental observations. Stable pinning is quantified theoretically via Bogoliubov-de Gennes excitation spectrum computations and confirmed via direct numerical simulations for a range of conditions similar to those of experimental observations. The theoretical and numerical results indicate that the pinned winding number, or equivalently the winding number of the superfluid current about the laser beam, decays as a laser beam of fixed intensity moves away from the BEC center. Our theoretical analysis helps explain previous experimental observations and helps define limits of stable vortex pinning for future experiments involving vortex manipulation by laser beams.

  19. Functional coupling between sodium-activated potassium channels and voltage-dependent persistent sodium currents in cricket Kenyon cells.

    Science.gov (United States)

    Takahashi, Izumi; Yoshino, Masami

    2015-10-01

    In this study, we examined the functional coupling between Na(+)-activated potassium (KNa) channels and Na(+) influx through voltage-dependent Na(+) channels in Kenyon cells isolated from the mushroom body of the cricket Gryllus bimaculatus. Single-channel activity of KNa channels was recorded with the cell-attached patch configuration. The open probability (Po) of KNa channels increased with increasing Na(+) concentration in a bath solution, whereas it decreased by the substitution of Na(+) with an equimolar concentration of Li(+). The Po of KNa channels was also found to be reduced by bath application of a high concentration of TTX (1 μM) and riluzole (100 μM), which inhibits both fast (INaf) and persistent (INaP) Na(+) currents, whereas it was unaffected by a low concentration of TTX (10 nM), which selectively blocks INaf. Bath application of Cd(2+) at a low concentration (50 μM), as an inhibitor of INaP, also decreased the Po of KNa channels. Conversely, bath application of the inorganic Ca(2+)-channel blockers Co(2+) and Ni(2+) at high concentrations (500 μM) had little effect on the Po of KNa channels, although Cd(2+) (500 μM) reduced the Po of KNa channels. Perforated whole cell clamp analysis further indicated the presence of sustained outward currents for which amplitude was dependent on the amount of Na(+) influx. Taken together, these results indicate that KNa channels could be activated by Na(+) influx passing through voltage-dependent persistent Na(+) channels. The functional significance of this coupling mechanism was discussed in relation to the membrane excitability of Kenyon cells and its possible role in the formation of long-term memory.

  20. Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy.

    Science.gov (United States)

    Shao, Hui; Yang, Yang; Mi, Ze; Zhu, Guang-Xi; Qi, Ai-Ping; Ji, Wei-Gang; Zhu, Zhi-Ru

    2016-11-19

    Rhynchophylline (RIN) is a significant active component isolated from the Chinese herbal medicine Uncaria rhynchophylla. Several studies have demonstrated that RIN has a significant anticonvulsant effect in many types of epilepsy models in vivo. However, the mechanisms of the anticonvulsant effect remain elusive. Using combined methods of behavioral testing, immunofluorescence and electrophysiological recordings, we characterized the anticonvulsant effect of RIN in a pilocarpine-induced status epilepticus (SE) rat model of temporal lobe epilepsy (TLE) and investigated the underlying cellular mechanisms. In one set of experiments, rats received RIN treatment prior to pilocarpine injection. In a second set of experiments, rats received RIN treatment following the onset of stage 3 seizures. Pretreatment and posttreatment with RIN effectively reduced the seizure severity in the acute phase of TLE. Furthermore, RIN protected medial entorhinal cortex (mEC) layer III neurons from neuronal death and terminated spontaneous epileptiform discharge of mEC layer II neurons in SE-experienced rats. Whole-cell voltage-clamp recordings indicated that RIN inhibited neuronal hyperexcitability via inhibition of the persistent sodium current (INaP) and NMDA receptor current. Immunofluorescence experiments also demonstrated that RIN rectified the pilocarpine-induced upregulation of Nav1.6 and NR2B protein expression. In conclusion, our results identified RIN as an anticonvulsant agent that inhibited ictal discharge via INap and NMDA receptor current inhibition.

  1. The Contribution of the Nearest-Neighborhood Interaction to the Persistent Current in a Mesoscopic Ring Studied by a New Model

    Institute of Scientific and Technical Information of China (English)

    HE Guang-Ping; LI Hua-Zhong; MA Zhong-Shui

    2001-01-01

    We propose an effective description of the interaction between the nearest-neighboring particles in a continuum theory. The contributions of the electron-electron interaction to the persistent current in 1D strongly correlating mesoscopic rings with or without impurities are analyzed. It is shown that the nearest-neighborhood int eraction gives significant contributions to the current and correlation functions. The enhance of the theoretical value of current magnitude is observed at finite temperature in the presence of the impurity scattering. The statistical property of the persistent current over random impurity distribution is also discussed. It is found that the exponential law of the persistent current for a non-interacting system will remain in an interacting one, as long as the interactions between nonnearest-neighborhoods are excluded.

  2. Therapeutic antibodies: current state and future trends--is a paradigm change coming soon?

    Science.gov (United States)

    Dimitrov, Dimiter S; Marks, James D

    2009-01-01

    Antibody-based therapeutics currently enjoy unprecedented success, growth in research and revenues, and recognition of their potential. It appears that the promise of the "magic bullet" has largely been realized. There are currently 22 monoclonal antibodies (mAbs) approved by the United States Food and Drug Administration (FDA) for clinical use and hundreds are in clinical trials for treatment of various diseases including cancers, immune disorders, and infections. The revenues from the top five therapeutic antibodies (Rituxan, Remicade, Herceptin, Humira, and Avastin) nearly doubled from $6.4 billion in 2004 to $11.7 billion in 2006. During the last several years major pharmaceutical companies raced to acquire antibody companies, with a recent example of MedImmune being purchased for $15.6 billion by AstraZeneca. These therapeutic and business successes reflect the major advances in antibody engineering which have resulted in the generation of safe, specific, high-affinity, and non-immunogenic antibodies during the last three decades. Currently, second and third generations of antibodies are under development, mostly to improve already existing antibody specificities. However, although the refinement of already known methodologies is certainly of great importance for potential clinical use, there are no conceptually new developments in the last decade comparable, for example, to the development of antibody libraries, phage display, domain antibodies (dAbs), and antibody humanization to name a few. A fundamental question is then whether there will be another change in the paradigm of research as happened 1-2 decades ago or the current trend of gradual improvement of already developed methodologies and therapeutic antibodies will continue. Although any prediction could prove incorrect, it appears that conceptually new methodologies are needed to overcome the fundamental problems of drug (antibody) resistance due to genetic or/and epigenetic alterations in cancer and

  3. Current trends in management of hepatitis B virus reactivation in the biologic therapy era

    Institute of Scientific and Technical Information of China (English)

    Claudio M Mastroianni; Miriam Lichtner; Rita Citton; Cosmo Del Borgo; Angela Rago; Helene Martini; Giuseppe Cimino; Vincenzo Vullo

    2011-01-01

    Hepatitis B virus (HBV) reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents. In particular, the risk of HBV reactivation is heightened by the use monoclonal antibodies, such as rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and long-lasting immunosuppression. Emerging data indicate that HBV reactivation could also develop following the use of other biologic agents, such as tumor necrosis factor (TNF)-α inhibitors. When HBV reactivation is diagnosed, it is mandatory to suspend biologic treatment and start antiviral agents immediately. However, pre-emptive antiviral therapy prior to monoclonal antibody administration is crucial in preventing HBV reactivation and its clinical consequences. Several lines of evidence have shown that risk of HBV reactivation is greatly reduced by the identification of high-risk patients and the use of prophylactic antiviral therapy. In this article, we discuss current trends in the management of HBV reactivation in immunosuppressed patients receiving biologic therapy, such as rituximab, alemtuzumab and TNF-α antagonists.

  4. Constructed wetlands, 1991-2011: a review of research development, current trends, and future directions.

    Science.gov (United States)

    Zhi, Wei; Ji, Guodong

    2012-12-15

    This study explores a bibliometric approach to quantitatively evaluate global scientific constructed wetlands research, and statistically assess current trends, and future directions using the Science Citation Index Expanded (SCI-EXPANDED) database from 1991 to 2011. Articles referencing constructed wetlands were analyzed by accessing the following: publication language, output characteristics, publication performance by country and institution, author keywords, title words, and KeyWords Plus. Synthetically analyzing three keyword types, we concluded that the dominant constructed wetlands research hotspots from 1991 to 2011 included water, nutrients, plants, and flow. These four hotspots remained the most dominant research areas throughout our study period, and are predicted to remain the top research emphases in the near future. "Soil" also exhibited a notable increase since 2005, and is likely to become another notable area of research interest in the future. "Phytoremediation" and "horizontal" were not identified in 1991-1995, but exhibited marked increases from 136th (0.5%) and 169th (0.7%) in 1996-2000, to 9th (3.8%) and 11th (4.3%) in 2006-2011, respectively. Therefore, given the heightened attention during the last 15 years, these topics are likely to become a primary research focus in upcoming years.

  5. ANALYSIS OF CURRENT STATE AND FUTURE TRENDS OF AUTO PARTS MANUFACTURING SECTOR IN ROMANIA

    Directory of Open Access Journals (Sweden)

    DANIELA MIHAI

    2012-10-01

    Full Text Available In the economy of any country, the auto parts manufacturing sector holds an important percentage in the national automotive industry. The dynamics of sales within it can vary significantly on short term, depending on the automotive market trend. This is also the case of the current situation in Romania, where the effect of the regressive automotive sales evolution will propagate, most probably, with a significant delay for the companies involved in production and trade of auto parts (for both first-assembly manufacture and car maintenance and repair. The statistical data indicate that even though the total volume of vehicles delivered decreased with 7.4% in 2011 as compared to 2010, the total turnover of the companies in the automotive industry increased with 7.8%. The apparent paradox is explained in the present article through the particularities of the demand for spare parts intended for the rolling stock in operation and through the effective organization of the distribution system.

  6. Lifelong education for older adults in Malta: Current trends and future visions

    Science.gov (United States)

    Formosa, Marvin

    2012-04-01

    With European demographic developments causing a decline of the available workforce in the foreseeable future and the unsustainability of dominant pay-as-you-go pension systems (where contributions from the current workforce sustain pensioners), governments need to come up with strategies to deal with this upcoming challenge and to adjust their policies. Based on a study carried out between September 2009 and May 2010, this article evaluates the policies guiding late-life education in Malta, as well as the local plethora of learning opportunities for older adult education, and participation rates. The Maltese government is committed to supporting the inclusion of older persons (aged 60+) in lifelong education policies and programmes, to the extent that local studies have uncovered a recent rise in the overall participation of older adults in formal, non-formal and informal areas of learning. While the present and future prospects for late-life education in Malta seem promising, a critical scrutiny of present ideologies and trends finds the field to be no more than seductive rhetoric. Though the coordination of late-life education in Malta does result in various social benefits to older learners and Maltese society in general, it also occurs within five intersecting lines of inequality - namely an economic rationale, elitism, gender bias, the urban-rural divide and third ageism. This article ends by proposing policy recommendations for the future of late-life education.

  7. Current and future trends in educational computing: Implications for training language teachers

    Directory of Open Access Journals (Sweden)

    Jannie Botha

    2013-02-01

    Full Text Available In the first part of this paper an overview is given of the current state of educational technology as well as some future trends in this rapidly developing field. The focus is on developments with regard to hardware and software. It is pointed out that a clear distinction between hardware and software is not always possible. Specific reference is made to a Hypertext programme and the promises it holds for the future. In the second part of the paper specific guidelines for training teachers in computerassisted language instruction (CALl are given. This is done against the background given in the first part of the paper. Guidelines are proposed for the training of language teachers. In die eerste gedeelte van hierdie artikel word 'n oorsig gegee van die huidige stand van opvoedkundige tegnologie en ook sommige toekomsneigings op hierdie snelontwikkelende gebied. Die fokus vat op ontwikkelings ten opsigte van apparatuur en pro grammatuur. Daar word aangedui dat 'n duidelike onderskeid tussen apparatuur en programmatuur nie altyd moontlik is nie. Daar word spesifiek verwys na 'n hiperteksprogram en die moontlikhede wat dit vir die toekoms inhou. In die tweede gedeelte van die artikel word spesifieke riglyne vir die opleiding van rekenaargesteunde taalonderrigonderwysers (RGTO gegee. Dit word gedoen teen die agtergrond wat in die eerste gedeelte van die artikel gegee is. Riglyne vir die opleiding van taalonderwysers word voorgestel.

  8. Current trends in treatment outcomes of orbital cellulitis in a tertiary hospital in Southern Nigeria

    Directory of Open Access Journals (Sweden)

    Odarosa M Uhumwangho

    2016-01-01

    Full Text Available Background: Orbital cellulitis refers to the inflammation or infection of the soft tissues of the orbit located behind the orbital septum. Aim: To determine the current trends in the outcomes following the management of orbital cellulitis in a tertiary hospital in Southern Nigeria. Patients and Methods: A retrospective review of medical records of patients with orbital cellulitis from January 2008 to December 2014 was conducted. The age, sex, duration of symptoms, predisposing factors, clinical findings, laboratory/radiological investigations, treatment provided, complications, and follow-up were recorded. Results were analyzed with SPSS Version 21 program. Results: Forty-two patients were seen made of 17 (40.5% males and 25 (59.5% females with a mean age of 18.2 ± 18.7 years of which children 6/18 at presentation, 38 (82.6% and at discharge, 39 (84.8%. The mean duration of presenting complaints was 15.5 ± 31.6 days. Patients who presented early were less likely to develop complications, P = 0.003. The most common complication was exposure keratopathy in 8 (44.4% eyes. The only surgical intervention performed was incision and drainage of abscess in 3 (7.1% eyes. No patient came for follow-up. Conclusion: Prompt institution of effective antibiotics and management of complications that may arise improves prognosis of orbital cellulitis.

  9. Evaluation of current trends and recent development in insulin therapy for management of diabetes mellitus.

    Science.gov (United States)

    Nawaz, Muhammad Sarfraz; Shah, Kifayat Ullah; Khan, Tahir Mehmood; Rehman, Asim Ur; Rashid, Haroon Ur; Mahmood, Sajid; Khan, Shahzeb; Farrukh, Muhammad Junaid

    2017-07-08

    Diabetes mellitus is a major health problem in developing countries. There are various insulin therapies to manage diabetes mellitus. This systematic review evaluates various insulin therapies for management of diabetes mellitus worldwide. This review also focuses on recent developments being explored for better management of diabetes mellitus. We reviewed a number of published articles from 2002 to 2016 to find out the appropriate management of diabetes mellitus. The paramount parameters of the selected studies include the insulin type & its dose, type of diabetes, duration and comparison of different insulin protocols. In addition, various newly developed approaches for insulin delivery with potential output have also been evaluated. A great variability was observed in managing diabetes mellitus through insulin therapy and the important controlling factors found for this therapy include; dose titration, duration of insulin use, type of insulin used and combination therapy of different insulin. A range of research articles on current trends and recent advances in insulin has been summarized, which led us to the conclusion that multiple daily insulin injections or continuous subcutaneous insulin infusion (insulin pump) is the best method to manage diabetes mellitus. In future perspectives, development of the oral and inhalant insulin would be a tremendous breakthrough in Insulin therapy. Copyright © 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  10. MO-A-BRD-00: Current Trends in Y90-Microsphere Therapy: Delivery and Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    Yttrium-90 (Y90) microsphere therapy, a form of radiation therapy, is an increasingly popular option for care of patients with liver metastases or unresectable hepatocellular carcinoma. The therapy directly delivers Y90 microspheres via the hepatic artery to disease sites. Following delivery, a vast majority of microspheres preferentially lodge in the capillary vessels due to their embolic size and targeted trans-arterial delivery – depositing up to 90% of its energy in the first 5 mm of tissue. There have been a number of advances in tomographic imaging within both interventional radiology and nuclear medicine that has advanced therapy planning techniques. Quantitative imaging of Y90 microsphere distribution post-therapy has also seen innovations that have led to improvements in tumor dosimetry and characterization of tumor response. A review of current trends and recent innovation in Y90 microsphere therapies will be presented. Learning Objectives: To present the imaging requirements for Y90 microsphere therapy planning To explain the standard dosimetry models used in Y90 microsphere therapy planning To report on advances in imaging for therapy planning and posttherapy assessment of tumor dosimetry and response.

  11. Current Trends and Research Challenges in Spectrum-Sensing for Cognitive Radios

    Directory of Open Access Journals (Sweden)

    Roopali Garg

    2016-07-01

    Full Text Available The ever increasing demand of wireless communication systems has led to search of suitable spectrum bands for transmission of data. The research in the past has revealed that radio spectrum is under-utilized in most of the scenarios. This prompted the scientist to seek a solution to utilize the spectrum efficiently. Cognitive Radios provided an answer to the problem by sensing the idle (licensed bands and allowing (secondary users to transmit in these idle spaces. Spectrum sensing forms the main block of cognition cycle. This paper reviews the current trends in research in the domain of spectrum sensing. The author describes the type of channel being modelled, diversity combining schemes used, optimal algorithms applied at fusion centre, spectrum sensing techniques employed. Further, the research challenges are discussed. It is presented that various attributes like sensing time, throughput, rate reliability, optimum cooperative users, sensing frequency etc. needs to be addressed. A trade-off needs to be established to optimize two opposing parameters like sensing and throughput.

  12. Current Trends of High capacity Optical Interconnection Data Link in High Performance Optical Communication Systems

    Directory of Open Access Journals (Sweden)

    Ahmed Nabih Zaki Rashed

    2013-02-01

    Full Text Available Optical technologies are ubiquitous in telecommunications networks and systems, providing multiple wavelength channels of transport at 2.5 Gbit/sec to 40 Gbit/sec data rates over single fiber optic cables. Market pressures continue to drive the number of wavelength channels per fiber and the data rate per channel. This trend will continue for many years to come as electronic commerce grows and enterprises demand higher and reliable bandwidth over long distances. Electronic commerce, in turn, is driving the growth curves for single processor and multiprocessor performance in data base transaction and Web based servers. Ironically, the insatiable taste for enterprise network bandwidth, which has driven up the volume and pushed down the price of optical components for telecommunications, is simultaneously stressing computer system bandwidth increasing the need for new interconnection schemes and providing for the first time commercial opportunities for optical components in computer systems. The evolution of integrated circuit technology is causing system designs to move towards communication based architectures. We have presented the current tends of high performance system capacity of optical interconnection data transmission link in high performance optical communication and computing systems over wide range of the affecting parameters.

  13. The current status and trend of clinical pharmacology in developing countries

    Science.gov (United States)

    2013-01-01

    Background Several international forums for promoting clinical pharmacology in developing countries have been held since 1980, and several clinical pharmacology programmes targeting developing countries were instituted such that the status of clinical pharmacology in developing countries is not where it was 50 years ago. Therefore, a survey and an appraisal of the literature on the current status of clinical pharmacology in developing countries were undertaken with a hope that it would enable development of appropriate strategies for further promotion of clinical pharmacology in these countries. Methods First, nine determinants (or enabling factors) for running a successful clinical pharmacology programme were identified, i.e., disease burden, drug situation, economic growth, clinical pharmacology activities, recognition, human capital, government support, international collaboration, and support for traditional/alternative medicines. These factors were then evaluated with regard to their current status in the developing countries that responded to an electronic questionnaire, and their historical perspective, using the literature appraisal. From these, a projected trend was constructed with recommendations on the way forward. Results Clinical pharmacology services, research and teaching in developing countries have improved over the past 50 years with over 90% of countries having the appropriate policies for regulation and rational use of medicines in place. Unfortunately, policy implementation remains a challenge, owing to a worsening disease burden and drug situation, versus fewer clinical pharmacologists and other competing priorities for the national budgets. This has led to a preference for training ‘a physician clinical pharmacologist’ in programmes emphasizing local relevancy and for a shorter time, and the training of other professionals in therapeutics for endemic diseases (task shifting), as the most promising strategies of ensuring rational use of

  14. Current trends of Mycobacterium tuberculosis molecular epidemiology in Saudi Arabia and associated demographical factors.

    Science.gov (United States)

    Al-Hajoj, Sahal; Varghese, Bright; Al-Habobe, Farah; Shoukri, Mohammed M; Mulder, Arnout; van Soolingen, Dick

    2013-06-01

    Data are scarce on demographical factors related to the population structure of Mycobacterium tuberculosis in Saudi Arabia. A study was conducted on 902 clinical isolates to explore current trends in the phylogeography and associated demographical factors of tuberculosis by using spoligotyping and 24 loci based MIRU-VNTR typing. Young male patients (aged 16-29 and 30-44) were predominant in this cohort. The phylogenetic diversity among M. tuberculosis isolates was found high, as almost all known genetic lineages were identified. Delhi/CAS (26.4%), EAI (13.7%) and Haarlem (11.3%) were the most common lineages observed, particularly among the low age groups (16-29 and 30-44 years), whereas elderly patients (>60 years) showed a predominance in the lineages S, Ghana, TUR and Uganda-I. A statistically significant association was observed between gender of the patients and lineages of EAI (p value 0.026) and LAM (p value 0.005). Overall, molecular strain cluster rate was 34.4% with an elevated rate among patients aged below 15 years (43.1%), while cases among the elderly (>60 years) showed the lowest degree of clustering (12.5%). The largest level of clustering was noticed among cases caused by strains of the lineages Haarlem (59.8%), Beijing (55.8%) and LAM (42.8%). The current population structure of M. tuberculosis in Saudi Arabia is highly diverse with significant associations to demography, transmission dynamics and origin of the patients. The difference in genotype distributions among low and high aged patients reflects the ongoing change in the strain population structure in the country.

  15. Trends and current status of general thoracic surgery in Japan revealed by review of nationwide databases.

    Science.gov (United States)

    Okumura, Meinoshin

    2016-08-01

    Nationwide databases of cases treated for thoracic disease have been established by several academic associations in Japan, which contain information showing trends and current status in regard to surgical treatment. The Japanese Association of Thoracic Surgery (JATS), Japanese Association of Chest Surgery (JACS), Japan Lung Cancer Society (JLCS), Japanese Respiratory Society (JRS), and Japan Society for Respiratory Endoscopy (JSRE) have maintained databases of lung cancer cases treated in Japan. In 1986, the number of general thoracic surgery cases was 15,544, which increased to 75,306 in 2013. Furthermore, the number of lung cancer operations performed in 2013 was 37,008, occupying 49.1% of all general thoracic operations. Also, the proportions of adenocarcinoma, female patients, aged patients, stage I disease, and limited resection procedures are increasing in lung cancer surgery cases. While the 5-year overall post-operative survival rate of lung cancer patients was 47.8% in those undergoing surgery in 1989, it was 69.6% in those of 2004, which means 22% increase during 15 years. JATS, JACS, and the Japanese Association for Research of the Thymus (JART) have maintained retrospective databases of thymic epithelial tumor cases. The number of mediastinal tumors surgically treated is also increasing and was 4,780 in 2013, among which thymoma was the most prevalent. The Japanese Association for Lung and Heart-Lung Transplantation has developed a prospective nationwide database of lung transplantation cases in Japan, which contains clinical data for 466 patients who received lung transplantation or heart-lung transplantation from 1998 to 2015. Nationwide databases are currently being utilized for clinical studies and will also contribute to international projects related to the Union for International Cancer Control (UICC) tumor, node, and metastasis (TNM) classification system.

  16. Current Status and Trend of Internet and E-Commerce Market in Korea

    Institute of Scientific and Technical Information of China (English)

    LEE Hongjoo; KIM Jongwoo; PARK Sungjoo

    2004-01-01

    After the remarkable increase of Internet users and broadband Internet subscribers at the end of the 20th century, the size of Korean Internet and e-commerce market steadily increased but the growth rate has been either stagnant or decreased. Trends of Korean Internet and e-commerce market are summarized in this paper the trends on Internet usage are introduced. Trends of online games, blogs and wireless Internet are introduced. The trends of Korean Internet market may have implications for China and Japan.

  17. Review of Current Studies in Instructional Design Theory in Korea: Major Trends and Future Directions

    Science.gov (United States)

    Lim, Cheolil; Yeon, Eunkyoung

    2009-01-01

    This article reviewed recent studies of instructional design theory in Korea to explore major trends and suggest future directions. Based on the analysis of 40 articles from the "Journal of Educational Technology" between 1994 and 2006, this study identified six trends: little emphasis on the conceptualization of instructional design…

  18. Current Trends in the Detection of Sociocultural Signatures: Data-Driven Models

    Energy Technology Data Exchange (ETDEWEB)

    Sanfilippo, Antonio P.; Bell, Eric B.; Corley, Courtney D.

    2014-09-15

    available that are shaping social computing as a strongly data-driven experimental discipline with an increasingly stronger impact on the decision-making process of groups and individuals alike. In this chapter, we review current advances and trends in the detection of sociocultural signatures. Specific embodiments of the issues discussed are provided with respect to the assessment of violent intent and sociopolitical contention. We begin by reviewing current approaches to the detection of sociocultural signatures in these domains. Next, we turn to the review of novel data harvesting methods for social media content. Finally, we discuss the application of sociocultural models to social media content, and conclude by commenting on current challenges and future developments.

  19. Levels, fluxes and time trends of persistent organic pollutants in Lake Thun, Switzerland: Combining trace analysis and multimedia modeling

    Energy Technology Data Exchange (ETDEWEB)

    Bogdal, Christian [Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zuerich (Switzerland); Empa, Swiss Federal Laboratories for Materials Testing and Research, Uberlandstrasse 129, CH-8600 Duebendorf (Switzerland); Scheringer, Martin, E-mail: scheringer@chem.ethz.ch [Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zuerich (Switzerland); Schmid, Peter [Empa, Swiss Federal Laboratories for Materials Testing and Research, Uberlandstrasse 129, CH-8600 Duebendorf (Switzerland); Blaeuenstein, Markus [Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zuerich (Switzerland); Kohler, Martin [State Food Law Enforcement Authority, Werkhofstrasse 5, CH-4509 Solothurn (Switzerland); Hungerbuehler, Konrad [Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zuerich (Switzerland)

    2010-08-01

    Levels, mass fluxes, and time trends of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in Lake Thun, a peri-Alpine lake, are investigated. We present measurements of PBDEs and PCBs in air, lake water, lake sediment, and tributary water. These measurements are combined with a multimedia fate model, based on site-specific environmental parameters from the lake catchment. Measured loadings of PBDEs and PCBs in air and tributaries were used to drive the model. The model satisfactorily reproduces PBDE and PCB congener patterns in water and sediment, but it tends to yield concentrations in water below the measurements and concentrations in sediment exceeding the measurements. A sensitivity analysis reveals that partitioning of PBDEs and PCBs between the aqueous dissolved phase and suspended particulate matter in the water column strongly affects the model results, in particular the concentrations in water and sediment. For lower-brominated PBDEs, approximately 70% and 30% of input into the lake stems from atmospheric deposition and from tributaries, respectively. For heavier PBDEs and all PCBs, rivers appear to deliver the major load (64-92%). Waste water effluents are of minor importance. 50-90% of the total input is buried in the permanent sediment. Sediment burial makes PBDEs and PCBs less available for recycling in the environment, and reduces concentrations in the outflowing river. If use of deca-BDE increases in the future, levels in Lake Thun will follow the same trend. If the use and resulting environmental emissions decrease, concentrations in water will rapidly decline, according to our calculations, while sediment levels will decrease at a considerably slower rate.

  20. Assessing seasonal and spatial trends of persistent organic pollutants (POPs) in Indian agricultural regions using PUF disk passive air samplers

    Energy Technology Data Exchange (ETDEWEB)

    Pozo, Karla [Atmospheric Science and Technology Directorate, Environment Canada, 4905 Dufferin Street, Toronto, Ontario M3H 5T4 (Canada); Environmental Science Department, University of Siena, Via Mattioli 4, 53100 Siena (Italy); Harner, Tom, E-mail: tom.harner@ec.gc.c [Atmospheric Science and Technology Directorate, Environment Canada, 4905 Dufferin Street, Toronto, Ontario M3H 5T4 (Canada); Lee, Sum Chi [Atmospheric Science and Technology Directorate, Environment Canada, 4905 Dufferin Street, Toronto, Ontario M3H 5T4 (Canada); Sinha, Ravindra K. [Centre for Environmental Science, School of Earth Biological and Environmental Sciences, Central University of Bihar, Patna (India); Sengupta, B. [Central Pollution Control Board, Parivesh Bhavan, East Arjun Nagar, Delhi (India); Loewen, Mark [Freshwater Institute, Department of Fisheries and Oceans, Winnipeg, Manitoba (Canada); Geethalakshmi, V. [Department of Agricultural Meteorology, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu (India); Kannan, Kurunthachalam [Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, State University of New York at Albany, New York (United States); Volpi, Valerio [Environmental Science Department, University of Siena, Via Mattioli 4, 53100 Siena (Italy)

    2011-02-15

    The first survey of persistent organic pollutant (POP) concentrations in air across several Indian agricultural regions was conducted in 2006-2007. Passive samplers comprising polyurethane foam (PUF) disks were deployed on a quarterly basis at seven stations in agricultural regions, one urban site and one background site. The project was conducted as a sub-project of the Global Atmospheric Passive Sampling (GAPS) Network. In addition to revealing new information on air concentrations of several organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), the study has demonstrated the feasibility of conducting regional-scale monitoring for POPs in India using PUF disk samplers. The following analytes were detected with relatively high concentrations in air (mean for 2006 and 2007, pg/m{sup 3}): {alpha}- and {gamma}-hexachlorocyclohexane (HCH) (292 and 812, respectively); endosulfan I and II (2770 and 902, respectively); p,p'-DDE and p,p'-DDT (247 and 931, respectively); and for the sum of 48 PCBs, 12,100 (including a site with extremely high air concentrations in 2007) and 972 (when excluding data for this site). - New data on air concentrations of POPs across Indian agricultural regions is generated using cost-effective passive air samplers.

  1. Persistent organic pollutants (POPs) in the atmosphere of coastal areas of the Ross Sea, Antarctica: Indications for long-term downward trends.

    Science.gov (United States)

    Pozo, Karla; Martellini, Tania; Corsolini, Simonetta; Harner, Tom; Estellano, Victor; Kukučka, Petr; Mulder, Marie D; Lammel, Gerhard; Cincinelli, Alessandra

    2017-07-01

    Passive air samplers were used to evaluate long-term trends and spatial distribution of trace organic compounds in Antarctica. Duplicate PUF disk samplers were deployed at six automatic weather stations in the coastal area of the Ross sea (East Antarctica), between December 2010 and January 2011, during the XXVI Italian Scientific Research Expedition. Among the investigated persistent organic compounds, Hexachlorobenzene was the most abundant, with air concentrations ranging from 0.8 to 50 pg m(-3). In general, the following decreasing concentration order was found for the air samples analyzed: HCB > PeCB > PCBs > DDTs > HCHs. While HCB concentrations were in the same range as those reported in the atmosphere of other Antarctic sampling areas and did not show a decline, HCHs and DDTs levels were lower or similar to those determined one or two decades ago. In general, the very low concentrations reflected the pristine state of the East Antarctica air. Backward trajectories indicated the prevalence of air masses coming from the Antarctic continent. Local contamination and volatilization from ice were suggested as potential sources for the presence of persistent organic pollutants in the atmosphere. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. The persistent sodium current generates pacemaker activities in the central pattern generator for locomotion and regulates the locomotor rhythm.

    Science.gov (United States)

    Tazerart, Sabrina; Vinay, Laurent; Brocard, Frédéric

    2008-08-20

    Rhythm generation in neuronal networks relies on synaptic interactions and pacemaker properties. Little is known about the contribution of the latter mechanisms to the integrated network activity underlying locomotion in mammals. We tested the hypothesis that the persistent sodium current (I(NaP)) is critical in generating locomotion in neonatal rodents using both slice and isolated spinal cord preparations. After removing extracellular calcium, 75% of interneurons in the area of the central pattern generator (CPG) for locomotion exhibited bursting properties and I(NaP) was concomitantly upregulated. Putative CPG interneurons such as commissural and Hb9 interneurons also expressed I(NaP)-dependent (riluzole-sensitive) bursting properties. Most bursting cells exhibited a pacemaker-like behavior (i.e., burst frequency increased with depolarizing currents). Veratridine upregulated I(NaP), induced riluzole-sensitive bursting properties, and slowed down the locomotor rhythm. This study provides evidence that I(NaP) generates pacemaker activities in CPG interneurons and contributes to the regulation of the locomotor activity.

  3. The Future of e-Learning in Medical Education: Current Trend and Future Opportunity

    Directory of Open Access Journals (Sweden)

    Sara Kim

    2006-09-01

    Full Text Available A wide range of e-learning modalities are widely integrated in medical education. However, some of the key questions related to the role of e-learning remain unanswered, such as (1 what is an effective approach to integrating technology into pre-clinical vs. clinical training?; (2 what evidence exists regarding the type and format of e-learning technology suitable for medical specialties and clinical settings?; (3 which design features are known to be effective in designing on-line patient simulation cases, tutorials, or clinical exams?; and (4 what guidelines exist for determining an appropriate blend of instructional strategies, including online learning, face-to-face instruction, and performance-based skill practices? Based on the existing literature and a variety of e-learning examples of synchronous learning tools and simulation technology, this paper addresses the following three questions: (1 what is the current trend of e-learning in medical education?; (2 what do we know about the effective use of e-learning?; and (3 what is the role of e-learning in facilitating newly emerging competency-based training? As e-learning continues to be widely integrated in training future physicians, it is critical that our efforts in conducting evaluative studies should target specific e-learning features that can best mediate intended learning goals and objectives. Without an evolving knowledge base on how best to design e-learning applications, the gap between what we know about technology use and how we deploy e-learning in training settings will continue to widen.

  4. ENDF/B-VII.1 library - current and future trends in reaction data

    Science.gov (United States)

    Herman, Michal

    2011-10-01

    The ENDF/B-VII.0 library, made available in December 2006, has been the first major release of the US nuclear reaction data library in 16 years. Intensive validation proved generally good performance of the library but a number of deficiencies were discerned. In 2008 CSEWG decided to undertake multi-laboratory effort leading to VII.1 version, which is scheduled for release in December 2011. Highlights of the new library include (i) a consistent set of covariance data, for over 180 materials, targeting explicit needs of the Advanced Fuel Cycle Initiative, (ii) new R-matrix based evaluations for several light nuclei, (iii) evaluations for reactions on structural materials in both the fast neutron region and the resonance region, (iv) improvements of resonances regions and thermal cross sections for certain fission products and neutron absorber materials (Cd, Gd), (v) improvements in minor actinide evaluations for isotopes of U, Np, Pu, and Am, (vi) adoption of JENDL4.0 evaluations for the Cm, Bk, Cf, Es, Fm, and some other minor actinides, (vii) fission product yield advances for fission-spectrum neutrons and 14 MeV neutrons incident on 239Pu, and (viii) a new Decay Data sub-library. No significant changes are expected for the major actinides 235,8U and 239Pu, except reverting delayed neutron data to ENDF/B-VI.8 and adding covariances. Current update concerns only the most important neutron, fission yields, and decay data sub-libraries leaving the remaining 11 sub-libraries unchanged. Open issues and trends for the future releases of the ENDF/B will be discussed.

  5. The Development of Perioperative Practices for Liver Transplantation: Advances and Current Trends

    Directory of Open Access Journals (Sweden)

    Merceds Susan Mandell

    2008-09-01

    Full Text Available Transplantation is a young medical specialty that has grown rapidly over the past 50 years. Anesthesiologists, surgeons and hepatologists are all essential partners in the process of determining patient outcome. Each specialty has made landmark improvements in patient outcome. However, there is still variability in practice patterns in each of the 3 major specialties. This review will use a historic perspective to explore the unique forces that shaped specific transplant practices and those that gave rise to differences in perioperative practices. Anesthesiologists and surgeons have made significant improvements in the management of blood loss, and coagulation monitoring and intervention. This has improved operative survival and early patient outcome. Perioperative survival has improved despite a worldwide shortage of donor organs and a trend to transplant sicker patients. A smaller pool of donor organs is required to meet the needs of an expanding waiting list. The innovations to reduce deaths on the transplant wait list are reviewed along with their impact on overall patient outcome. The evolving organ shortage is the pinnacle point in shaping future transplant practices. Currently, institutional-specific practices may be reinforced by the informal “tutorship” that is used to train physicians and by the resources available at each site of practice. However, there is evidence that specific intraoperative practices such as the use of a low central venous pressure, selection of vasopressors and certain surgical techniques can modify patient outcome. Further investigation is needed to determine whether the good or the bad associated with each practice prevails and in what unique circumstance.

  6. Current trends in management of men with lower urinary tract symptoms and benign prostatic hyperplasia.

    Science.gov (United States)

    Holtgrewe, H L

    1998-04-01

    Management of lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) has been central to urology for decades. The urologic community has increasingly come to realize that many men with LUTS do not have prostate enlargement and do not need their prostates debulked surgically. Of all the factors that have emerged to alter the trends associated with management of LUTS and BPH, none has had more impact than the advent of medical therapy. The selective, long-acting, alpha1-blocking agents terazosin, doxazosin, and tamsulosin have become most popular because of their specificity in the urinary tract, reduced side effects, and simplicity of dosage. In addition, finasteride, a 5-alpha-reductase inhibitor, was found to be effective in men with prostates of > or = 40 g. Furthermore, the larger the prostate at baseline, the greater the efficacy of finasteride on symptom relief and flow rate improvement. In addition to medical therapy, an array of device therapies has emerged in the management of LUTS and BPH. Laser prostatectomy is the oldest of the device therapies and includes transurethral vaporization of the prostate (VLAP), transurethral evaporation of the prostate (TUEP), and transurethral interstitial laser prostatectomy (TILP). Studies report beneficial outcomes approaching those achieved with transurethral resection of the prostate (TURP) with less morbidity and a shorter hospital stay. Common diseases contribute the most to national healthcare expenditures. The management of LUTS and BPH are such disorders and result in the expenditure of vast healthcare resources worldwide. The surgical strategies have an established record of outcomes documenting their potential for symptom relief and the avoidance of future complications. Medical and device therapies, although currently promising and attractive, therefore must prove comparable durability.

  7. Current trends of carcinoma tongue at a Medical College in Central India: A retrospective study

    Directory of Open Access Journals (Sweden)

    Vikrant Ranjan

    2014-01-01

    Full Text Available Context : Oral cancer is the most common cancer in India and tongue is one of the most commonly affected site. Aims and Objectives : The current study assesses the clinico-epidemiological trends of carcinoma tongue, its survival rates in different stages and relationship between different variables in central India. Materials and Methods : This was a retrospective study of 121 carcinoma tongue patients admitted between the period of 2½ years in a hospital of central India. The data collected were age and sex distribution, location and site of the tumor, tumor stage, histopathological type and grade, nodal status, modality of treatment, recurrences and survival. The disease free survival (DFS was analyzed against stage, nodal status and recurrences using log rank test. Results : In this study, the incidence of cancer was more in males (male: female = 6.1:1 particularly in their fifth decade (mean 52.7 years and the most common location was anterior 2/3 rd of the tongue mainly on right lateral side. Most of the patients presenting to out-patient department were having neck nodes positive status. The clinical stage at presentation was mainly advanced stages with well-differentiated squamous cell carcinoma. The most common treatment offered was surgery with radiotherapy (RT, followed by chemotherapy plus RT. The mean DFS time was of 27.8 ± 1.68 months, and it was directly related to tumor stage (P < 0.0001 in comparison to nodes positivity and recurrences. Conclusion : The study signifies better prognosis of carcinoma tongue in early stages and warrants more awareness campaigns and health education in the health facilities as well as in community for early diagnosis of the disease with proper staging and subsequently multimodal treatment for increasing survival rates.

  8. A Study of Current Trends and Issues for Graphics Education: Results from a Five-Year Follow-Up Survey

    Science.gov (United States)

    Clark, Aaron C.; Scales, Alice Y.

    2006-01-01

    During the 1998-1999 academic year, a survey was conducted to look at current trends and issues in the profession of graphics education (Clark & Scales, 1999). The survey solicited information from the membership of the Engineering Design Graphics Division of the American Society for Engineering Education related to their view of future areas of…

  9. Persistent sodium current contributes to induced voltage oscillations in locomotor-related hb9 interneurons in the mouse spinal cord.

    Science.gov (United States)

    Ziskind-Conhaim, Lea; Wu, Linying; Wiesner, Eric P

    2008-10-01

    Neurochemically induced membrane voltage oscillations and firing episodes in spinal excitatory interneurons expressing the HB9 protein (Hb9 INs) are synchronous with locomotor-like rhythmic motor outputs, suggesting that they contribute to the excitatory drive of motoneurons during locomotion. Similar to central pattern generator neurons in other systems, Hb9 INs are interconnected via electrical coupling, and their rhythmic activity does not depend on fast glutamatergic synaptic transmission. The primary objective of this study was to determine the contribution of fast excitatory and inhibitory synaptic transmission and subthreshold voltage-dependent currents to the induced membrane oscillations in Hb9 INs in the postnatal mouse spinal cord. The non-N-methyl-D-aspartate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced the amplitude of voltage oscillations but did not alter their frequency. CNQX suppressed rhythmic motor activity. Blocking glycine and GABAA receptor-mediated inhibitory synapses as well as cholinergic transmission did not change the properties of CNQX-resistant membrane oscillations. However, disinhibition triggered new episodes of slow motor bursting that were not correlated with induced locomotor-like rhythms in Hb9 INs. Our observations indicated that fast excitatory and inhibitory synaptic inputs did not control the frequency of induced rhythmic activity in Hb9 INs. We next examined the contribution of persistent sodium current (INaP) to subthreshold membrane oscillations in the absence of primary glutamatergic, GABAergic and glycinergic synaptic drive to Hb9 INs. Low concentrations of riluzole that blocked the slow-inactivating component of sodium current gradually suppressed the amplitude and reduced the frequency of voltage oscillations. Our finding that INaP regulates locomotor-related rhythmic activity in Hb9 INs independently of primary synaptic transmission supports the concept that these neurons constitute an

  10. How cesium dialysis affects the passive properties of pyramidal neurons: implications for voltage clamp studies of persistent sodium current

    Energy Technology Data Exchange (ETDEWEB)

    Fleidervish, Ilya A; Libman, Lior [Koret School of Veterinary Medicine, Hebrew University of Jerusalem, PO Box 12, Rehovot 76100 (Israel)], E-mail: fleider@agri.huji.ac.il

    2008-03-15

    In order to accurately understand and model neuronal integration in the brain, we must know the biophysical properties of channels that are located far from the soma, in the axonal and dendritic membranes of central nerve cells. Reliable electrophysiological measurements in these regions are difficult to obtain, because the processes are too tiny to directly study with an electrode. One common strategy is to record with a somatic electrode that contains Cs{sup +}, to dialyze the intracellular space with this K{sup +} channel blocker, and thereby to render the neuron electrotonically compact. Does this work? Here, we combine the experimental and modeling techniques to determine the extent to which a whole-cell voltage clamp, established with a Cs{sup +}-containing pipette in the soma of a cortical pyramidal cell, attains adequate voltage control of distal neuronal processes. We focus on the low-voltage-activated, slowly inactivating 'persistent' Na{sup +} current (I{sub NaP}), that plays a crucial role in determining neuronal excitability and synaptic integration.

  11. How cesium dialysis affects the passive properties of pyramidal neurons: implications for voltage clamp studies of persistent sodium current

    Science.gov (United States)

    Fleidervish, Ilya A.; Libman, Lior

    2008-03-01

    In order to accurately understand and model neuronal integration in the brain, we must know the biophysical properties of channels that are located far from the soma, in the axonal and dendritic membranes of central nerve cells. Reliable electrophysiological measurements in these regions are difficult to obtain, because the processes are too tiny to directly study with an electrode. One common strategy is to record with a somatic electrode that contains Cs+, to dialyze the intracellular space with this K+ channel blocker, and thereby to render the neuron electrotonically compact. Does this work? Here, we combine the experimental and modeling techniques to determine the extent to which a whole-cell voltage clamp, established with a Cs+-containing pipette in the soma of a cortical pyramidal cell, attains adequate voltage control of distal neuronal processes. We focus on the low-voltage-activated, slowly inactivating 'persistent' Na+ current (INaP), that plays a crucial role in determining neuronal excitability and synaptic integration.

  12. Food-aversive classical conditioning increases a persistent sodium current in molluscan withdrawal interneurons in a transcription dependent manner.

    Science.gov (United States)

    Kiss, Tibor; Pirger, Zsolt; Kemenes, György

    2009-07-01

    In this study we examined changes in a persistent sodium current (I(NaP)) after behavioral aversive classical conditioning in the snail Helix pomatia. We trained animals by pairing food with a mild electric shock that triggered the whole-body withdrawal reflex. This aversive training resulted in transcription dependent long-term associative memory. Isolated central nervous system preparations were set up from trained, random control and naive animals and using two-electrode voltage clamp methods, I(NaP) was activated and measured in identified body withdrawal interneurons RPa3 and LPa3. We show here that in preparations from conditioned animals I(NaP) is increased, suggesting that modifications in intrinsic cellular properties contribute to the formation of the memory trace. Blocking RNA synthesis by systemic injection of actinomycin D (0.12microM) suppressed both memory consolidation in intact animals and the learning-induced increase of I(NaP) in withdrawal interneurons, suggesting that aversive classical conditioning affects sodium channel expression at the transcriptional level.

  13. Currents trends in the application of IBA techniques to air pollution source fingerprinting and source apportionment

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, David; Stelcer, Ed.; Atanacio, Armand; Crawford, Jagoda [Australian Nuclear Science and Technology Organisation, Kirrawee DC (Australia)

    2013-07-01

    Full text: IBA techniques have been used for many years to characterise fine particle air pollution. This is not new the techniques are well established. Typically 2-3 MeV protons are used to bombard thin filter papers and up to four simultaneous techniques like PIXE, PIGE, RBS and ERDA will be applied to obtain (μg/g) concentrations for elements from hydrogen to lead. Generally low volume samplers are used to sample between 20-30 m{sup 3} of air over a 24 hour period, this together with IBA's sensitivity means that concentrations down to 1 ng/m{sup 3} of air sampled can be readily achieved with only a few minutes of proton irradiation. With these short irradiation times and low sensitivities for a broad range of elements in the periodic table, large numbers of samples can be obtained and analysed very quickly and easily. At ANSTO we have used IBA methods to acquire a database of over 50,000 filters from 85 different sites through Australia and Asia, each filter has been analysed for more than 21 different chemical species. Large databases extending over many years means that modern statistical techniques like positive matrix factorisation (PMF) can be used to define well characterised source fingerprints and source contributions for a range of different fine particle air pollutants. In this paper we will discuss these PMF techniques and show how they identify both natural sources like sea spray and windblown soils as well as anthropogenic sources like automobiles, biomass burning, coal-fired power stations and industrial emissions. These data are particularly useful for Governments, EPA's and managers of pollution to better understanding pollution sources and their relative contributions and hence to better manage air pollution. Current trends are to take these IBA and PMF techniques a step further and to combine them with wind speed and back trajectory data to better pin point and identify emission sources. We show how this is now being applied on both

  14. [Current trends of breast reconstruction after mastectomy for breast cancer patients in China: a survey report].

    Science.gov (United States)

    Chen, Ying; Chen, Jiajian; Chen, Jiaying; Yang, Benlong; Li, Lin; Huang, Xiaoyan; Shao, Zhimin; Shen, Zhenzhou; Yu, Peirong; Wu, Jiong

    2014-11-01

    To explore the current trends of breast reconstruction (BR) for breast cancer patients in China. A questionnaire was designed for this study, and it included questions on surgeon demographics, number of mastectomy and BR, type and timing of BR, reconstructive choices in the setting of preoperative or postoperative radiotherapy or chemotherapy, etc. All data were collected until December 2012. Questionnaires were sent to 52 members of the Committee of Breast Cancer Society by e-mail or mail. By July 2013, 41 questionnaires had been returned. Among all, 5 were excluded for not performing BR. These 36 hospitals covered 22 provinces and municipalities in China. A total of 538 surgeons working in the general surgery or oncological surgery department, but only 123 (22.9%) were qualified to perform BR. In 2012, except for 4 missing data, 24, 763 mastectomies were performed in 32 hospitals; among them, 1120 (4.5%) received BR. According to these 36 respondents, 32 (88.9%) performed prosthetic (1, 843 cases in all) while 4 (11.1%) performed prosthetic BR with acellular dermal matrix (17 cases in all) from the time of their first BR operation to the end of 2012. During the same period, 965 latissimus dorsi myocutaneous flaps with implant were performed in 23 (63.9%) hospitals while 738 latissimus dorsi myocutaneous flaps without implant were performed in 32 (88.9%) hospitals. At the same time, 366 pedicled transverse rectus abdominis myocutaneous flap BRs were performed in 28 (77.8%) hospitals, while 155 abdominal free flap BRs were carried out in 9 (25.0%) hospitals. The overall complication rate was 18.2%. Postoperative radiotherapy had some effect on influencing the esthetic outcomes of BR, so the autologous BR was recommended, but the timing remained controversial. Regarding chemotherapy, most respondents concluded that it had no effect or only a mild effect. The overall cosmetic outcomes of the reconstructed breasts satisfied the majority of physicians and patients

  15. Current Trends and Problems of Development of the Arctic Marine Freight Traffic

    Directory of Open Access Journals (Sweden)

    Vladimir Stepanovich Selin

    2015-09-01

    Full Text Available The article analyzes the trends and evaluates the prospects of functioning of the Northern Sea Route. It shows that after the change of its management model its freight traffic has dropped 4-fold, and in the Eastern sector (outside the Vilkitsky Strait – 40-fold. In the recent years there has been a certain revival of transportation, including transit, which reached its maximum of 1.27 million tons in 2012. However, over the next two years they declined again; the drop was particularly significant in 2014 and amounted to a total of 240 thousand tons. The main problem is that this rather complex system is influenced by many factors, often contradictory and poorly predictable. Thus, the growing need for energy resources determines the overall need for developing the Arctic shelf. However, the possibility of climate cooling and the deterioration of ice situation can influence the possibility of transporting these resources. Besides, the Ukrainian crisis followed by the “war of sanctions” will cause a significant decline, especially in the medium term, the attractiveness of the European oil and gas market, which will cause the shift of strategic interests of Russian companies to the Asia-Pacific region. This necessitates the modernization of the Arctic transport and logistics system and introduction of new technical solutions. For instance, even nuclearpowered icebreakers series LA-60Ya that are currently under construction will not be able to escort linear tankers and gas carriers with a deadweight of more than 100 thousand tons along the eastern sector of the Northern Sea Route. It is necessary to create more powerful vessels of the classical type or to design new models. All these driving forces and constraints are not always predictable within the framework of standard economic and statistical approaches. In this regard, the study reflected in the article used expert approaches along with the methods of factor and economic analysis. The

  16. Nonadiabatic Phase and Persistent Currents for System of Spin-1/2 Particles in Presence of Electromagnetic Fields and Spin-Orbit Interaction

    Institute of Scientific and Technical Information of China (English)

    LI Nian-Bei; MA Zhong-Shui

    2004-01-01

    We present a comprehensive view and details of calculations on Aharonov-Anandan phase for the charged particles in the external electric and magnetic fields for a nonadiabatic process. We derive, with consideration of a spin-orbit interaction and Zeemann Splitting, the persistent currents as a response to an Aharonov-Casher topological interference effect in one-dimensional mesoscopic ring. We also establish a connection to Berry adiabatic phase with deduced dynamical-nature dependence in the nonadiabatic process. The second quantization representation has also been employed in exhibition of persistent currents in the many-body case.

  17. Increased persistent sodium current due to decreased PI3K signaling contributes to QT prolongation in the diabetic heart.

    Science.gov (United States)

    Lu, Zhongju; Jiang, Ya-Ping; Wu, Chia-Yen C; Ballou, Lisa M; Liu, Shengnan; Carpenter, Eileen S; Rosen, Michael R; Cohen, Ira S; Lin, Richard Z

    2013-12-01

    Diabetes is an independent risk factor for sudden cardiac death and ventricular arrhythmia complications of acute coronary syndrome. Prolongation of the QT interval on the electrocardiogram is also a risk factor for arrhythmias and sudden death, and the increased prevalence of QT prolongation is an independent risk factor for cardiovascular death in diabetic patients. The pathophysiological mechanisms responsible for this lethal complication are poorly understood. Diabetes is associated with a reduction in phosphoinositide 3-kinase (PI3K) signaling, which regulates the action potential duration (APD) of individual myocytes and thus the QT interval by altering multiple ion currents, including the persistent sodium current INaP. Here, we report a mechanism for diabetes-induced QT prolongation that involves an increase in INaP caused by defective PI3K signaling. Cardiac myocytes of mice with type 1 or type 2 diabetes exhibited an increase in APD that was reversed by expression of constitutively active PI3K or intracellular infusion of phosphatidylinositol 3,4,5-trisphosphate (PIP3), the second messenger produced by PI3K. The diabetic myocytes also showed an increase in INaP that was reversed by activated PI3K or PIP3. The increases in APD and INaP in myocytes translated into QT interval prolongation for both types of diabetic mice. The long QT interval of type 1 diabetic hearts was shortened by insulin treatment ex vivo, and this effect was blocked by a PI3K inhibitor. Treatment of both types of diabetic mouse hearts with an INaP blocker also shortened the QT interval. These results indicate that downregulation of cardiac PI3K signaling in diabetes prolongs the QT interval at least in part by causing an increase in INaP. This mechanism may explain why the diabetic population has an increased risk of life-threatening arrhythmias.

  18. PREFACE: National Seminar on Current Trends in Materials Science (CTMS-2011)

    Science.gov (United States)

    Jayakrishnan, R.; Vijayakumar, K. P.; Unnikrishnan, N. V.

    2013-05-01

    India is going through an era of many changes in its higher education system. Emphasis is being given to research and development initiatives at Universities and colleges. The teaching community is faced with the challenge of coping with both regular academic activities and research initiatives. The teaching faculties need to keep in step with the momentous research output being generated globally. To mold young talent that will be sought after, teachers need to undertake challenging initiatives. Research in emerging areas like nanotechnology, meta materials, functional materials and structures is being pursued vigorously in Universities and colleges in the state of Kerala. Awareness of the impact of integrating teaching and research in basic science has inspired the teaching faculty. The number of seminars and conferences is not commensurate with the amount of research being conducted in this state. The state lags behind in the number of institutes with state of the art facilities and human resource with cutting edge knowledge. The national seminar on Current Trends in Materials Science (CTMS-2011) is organized by the Department of Physics, Christian College, Chengannur. It is a continuation of the initiatives of the Department to bridge the haitus between teaching and research. Current Trends in Materials Science (CTMS-2007) was successfully conducted with over 80 research paper presentations and participation of delegates from the states of Karnataka, Andhrapradesh, Tamilnadu and Kerala. CTMS-2011 is a sequel envisaged to serve as an effective platform for teachers to interact with eminent scientists and share their knowledge and experience. Papers were invited from the subject area comprising glasses and ceramics, crystal growth, nanotechnology, semiconductors thin films and polymers. We are delighted that after a peer review process of the papers we have selected ten of the best papers presented at the seminar for publication in IOP Conference Series

  19. Assessment of Cognitive Skills in the USSR: Historical Trends and Current Developments.

    Science.gov (United States)

    Holowinsky, Ivan Z.

    1985-01-01

    Assessment practices in the Soviet Union reveal three trends. The so-called pedology movement was replaced in the 1930s by an anti-testing policy, followed more recently by a reassessment of psychodiagnostic practices. Late 1970s and the beginning of 1980s reveal strong interests in psychodiagnosis. (Author/CL)

  20. Faculty Development for Advancing Community Engagement in Higher Education: Current Trends and Future Directions

    Science.gov (United States)

    Welch, Marshall; Plaxton-Moore, Star

    2017-01-01

    This research involved the conduct of a conceptual review of 28 refereed journal articles and a survey of campus centers for community engagement staff to identify salient features and trends of existing faculty development programming designed to advance service-learning and community engagement in higher education. Results of this investigation…

  1. Teaching Creativity: Current Findings, Trends, and Controversies in the Psychology of Creativity

    Science.gov (United States)

    Simonton, Dean Keith

    2012-01-01

    In the past decade, the psychological study of creativity has accelerated greatly. To facilitate the teaching of creativity, I provide an overview of the recent literature. The overview begins by discussing recent empirical results and research trends. This discussion specifically treats creativity's cognitive, differential, developmental, and…

  2. Current Developments in Education in Mexico and Trends for the 1980s: A Modified Delphi Project.

    Science.gov (United States)

    Sanders, Stanley G.

    Twenty-nine professional educators at the Universidad Autonoma de Guadalajara and post-graduate students of educational administration participated in a study to identify trends in education based on change in the society and the environment. Researchers used a modification of Delphi Technique, an intuitive method for organizing and sharing the…

  3. Teaching the Evolution of the Mind: Current Findings, Trends, and Controversies in Evolutionary Psychology

    Science.gov (United States)

    Liddle, James R.; Shackelford, Todd K.

    2011-01-01

    As the burgeoning field of evolutionary psychology continues to gain exposure and acceptance throughout the psychological community, it is important to explain this field clearly and accurately to students. This article discusses some recent findings and trends in evolutionary psychological research to aid instructors in their efforts to provide…

  4. Teaching the Evolution of the Mind: Current Findings, Trends, and Controversies in Evolutionary Psychology

    Science.gov (United States)

    Liddle, James R.; Shackelford, Todd K.

    2011-01-01

    As the burgeoning field of evolutionary psychology continues to gain exposure and acceptance throughout the psychological community, it is important to explain this field clearly and accurately to students. This article discusses some recent findings and trends in evolutionary psychological research to aid instructors in their efforts to provide…

  5. The persistent sodium current blocker riluzole is antiarrhythmic and anti-ischaemic in a pig model of acute myocardial infarction.

    Directory of Open Access Journals (Sweden)

    Steven M Weiss

    Full Text Available BACKGROUND: The potential of the cardiac persistent sodium current as a target for protection of the myocardium from ischaemia and reperfusion injury is gaining increasing interest. We have investigated the anti-ischaemic and antiarrhythmic effects of riluzole, a selective INaP blocker, in an open chest pig model of infarction. METHODS AND PRINCIPAL FINDINGS: The left anterior descending coronary artery (LAD was ligated in 27 anesthetised pigs (landrace or large white, either sex, 20-35 kg which had received riluzole (8 mg/kg IP; n = 6, lidocaine (2.5-12 mg/kg bolus plus 0.05-0.24 mg/kg/min; n = 11 or vehicle (n = 10 50 min prior. Arrhythmias could be delineated into phase 1a (0 to 20 min, phase 1b (20 to 50 min and phase 2 (from 50 min to termination at 180 min and were classified as premature ventricular contractions (PVCs, non-sustained ventricular tachycardia (VT or ventricular fibrillation (VF (spontaneously reverting within 15 s or sustained VT or VF (ie. requiring cardioversion at 15 s. Riluzole reduced the average number of all arrhythmias in Phase 2 (PVCs from 484+/-119 to 32+/-13; non sustained arrhythmias from 8.9+/-4.4 to 0.7+/-0.5; sustained arrhythmias from 3.9+/-2.2 to 0.5+/-0.4; lidocaine reduced the average number of non-sustained and sustained arrhythmias (to 0.4+/-0.3 and 0.4+/-0.3 respectively but not PVCs (to 390+/-234. Riluzole and lidocaine reduced the average number of sustained arrhythmias in phase 1b (from 1.8+/-0.4 to 0.17+/-0.13 (p<0.02 and to 0.55+/-0.26 (p = ns respectively. Neither lidocaine or riluzole changed the ECG intervals: there was no statistical significance between groups at time zero (just before ligation for any ECG measure. During the course of the 3 hour period of the ischaemia R-R, and P-R intervals shortened slightly in control and riluzole groups (not significantly different from each other but not in the lidocaine group (significantly different from control. QRS and QTc did not

  6. Trends in Health Information Technology Safety: From Technology-Induced Errors to Current Approaches for Ensuring Technology Safety

    OpenAIRE

    Borycki,Elizabeth

    2013-01-01

    Objectives Health information technology (HIT) research findings suggested that new healthcare technologies could reduce some types of medical errors while at the same time introducing classes of medical errors (i.e., technology-induced errors). Technology-induced errors have their origins in HIT, and/or HIT contribute to their occurrence. The objective of this paper is to review current trends in the published literature on HIT safety. Methods A review and synthesis of the medical and life s...

  7. Book Review: Siroj Sorajjakool: Human Trafficking in Thailand: Current Issues, Trends and the Role of the Thai Government

    OpenAIRE

    Manassinee Moottatarn

    2014-01-01

    Book Review of the Monograph: Siroj Sorajjakool (2013), Human Trafficking in Thailand: Current Issues, Trends and the Role of the Thai Government. Chiang Mai, Thailand: Silkworm Books, ISBN: 978-616-215-060-9, 235 pages. Human trafficking is not widely reported in local Thai news, and news of it is often only picked up by international correspondents. The extent of this problem has only started to reveal itself as a widespread problem in the kingdom.

  8. Book Review: Siroj Sorajjakool: Human Trafficking in Thailand: Current Issues, Trends and the Role of the Thai Government

    Directory of Open Access Journals (Sweden)

    Manassinee Moottatarn

    2014-01-01

    Full Text Available Book Review of the Monograph: Siroj Sorajjakool (2013, Human Trafficking in Thailand: Current Issues, Trends and the Role of the Thai Government. Chiang Mai, Thailand: Silkworm Books, ISBN: 978-616-215-060-9, 235 pages. Human trafficking is not widely reported in local Thai news, and news of it is often only picked up by international correspondents. The extent of this problem has only started to reveal itself as a widespread problem in the kingdom.

  9. Book Review: Siroj Sorajjakool: Human Trafficking in Thailand: Current Issues, Trends and the Role of the Thai Government

    OpenAIRE

    Manassinee Moottatarn

    2014-01-01

    Book Review of the Monograph: Siroj Sorajjakool (2013), Human Trafficking in Thailand: Current Issues, Trends and the Role of the Thai Government. Chiang Mai, Thailand: Silkworm Books, ISBN: 978-616-215-060-9, 235 pages. Human trafficking is not widely reported in local Thai news, and news of it is often only picked up by international correspondents. The extent of this problem has only started to reveal itself as a widespread problem in the kingdom.

  10. State standards for domestic violence perpetrator treatment: current status, trends, and recommendations.

    Science.gov (United States)

    Maiuro, Roland D; Eberle, Jane A

    2008-01-01

    We empirically surveyed and analyzed existing standards for the treatment of perpetrators of domestic violence across the United States. Specific areas examined included: presence and scope; administrative entity for certifying; screening and risk assessment protocols; minimum length of treatment; theoretical or conceptual orientation; treatment content; preferred or allowable modalities of treatment; whether research findings are mentioned; methods for revising standards; and minimum education and training required for providers. We examined trends using several methods including comparisons between present and previous survey data (Maiuro et al., 2001). Positive trends were evident including increased use of multivariate models of treatment content, use of an intake assessment prior to treatment, use of a danger/lethality assessment to manage risk, recognition of the need for program evaluation and supportive research, and the requirement of a minimum level of formal education as a prerequisite for providers. We identify specific areas for further research and development and make recommendations for improving existing practice and standards of care.

  11. Classification of future 5 MW turbines by extrapolation of current trends

    Energy Technology Data Exchange (ETDEWEB)

    Thakoer, R.; Van Kuik, G.A.M.; Van Leeuwen, H.L.

    1999-09-01

    This report is part of the STABTOOL project. The goals of the STABTOOL project can be summarised as follows: (1) first establish the elastic configuration of the present megawatt scaled wind turbines, and making an inventory of the present design trends and trends for future wind turbine developments w.r.t changes in the elastic configuration; (2) to make an inventory of the different types of instabilities which can occur for the present and next generation wind turbines for both onshore and offshore applications; (3) to make an inventory of analysis and design methods and development or adjustment of calculation methods. The final objective of the STABTOOL project is to create STABility TOOLs: a simple set of calculation models and methods for specific forms of aeroelastic instabilities and vibration problems which are applicable for both present and future large wind turbines. This report concerns the up scaling of the selected elastic configurations described in ST-NW-1-004: 2-blade, (active)pitch controlled, fixed speed (Kvaerner WTS 80M); 3-blade, (active)stall controlled, fixed speed (Nedwind 62 ); 3-blade, pitch controlled variable speed (Lagerwey 50/1000). Based on scaling rules and extrapolation of trend figures, the characteristics of the future 5MW class of wind turbines is estimated. The Nedwind based extrapolation is considered to be an onshore turbine, whereas the others are offshore. 5 refs.

  12. Visualization of e-Health Research Topics and Current Trends Using Social Network Analysis.

    Science.gov (United States)

    Son, Youn-Jung; Jeong, Senator; Kang, Byeong-Gwon; Kim, Sun-Hyung; Lee, Soo-Kyoung

    2015-05-01

    E-health has been grown rapidly with significant impact on quality and safety of healthcare. However, there is a large gap between the postulated and empirically demonstrated benefits of e-health technologies and a need for a clearer mapping of its conceptual domains. Therefore, this study aimed to critically review the main research topics and trends of international e-health through social network analysis. Medical subject heading terms were used to retrieve 3,023 research articles published from 1979 through 2014 in the PubMed database. We extracted n-grams from the corpus using a text analysis program, generated co-occurrence networks, and then analyzed and visualized the networks using Pajek software. The hub and authority measures identified the most important research topics in e-health. Newly emerging topics by 4-year period units were identified as research trends. The most important research topics in e-health are personal health records (PHR), health information technology, primary care, mobile health, clinical decision support systems (CDSS), and so on. The eight groups obtained through ego network analysis can be divided into four semantically different areas, as follows: information technology, infrastructure, services, and subjects. Also, four historical trends in e-health research are identified: the first focusing on e-health and telemedicine; the second, PHR and monitoring; the third, CDSS and alert; and the fourth, mobile health and health literacy. This study promotes a systematic understanding of e-health by identifying topic networks, thereby contributing to the future direction of e-health research and education.

  13. Current trends and new challenges of databases and web applications for systems driven biological research

    Directory of Open Access Journals (Sweden)

    Pradeep Kumar eSreenivasaiah

    2010-12-01

    Full Text Available Dynamic and rapidly evolving nature of systems driven research imposes special requirements on the technology, approach, design and architecture of computational infrastructure including database and web application. Several solutions have been proposed to meet the expectations and novel methods have been developed to address the persisting problems of data integration. It is important for researchers to understand different technologies and approaches. Having familiarized with the pros and cons of the existing technologies, researchers can exploit its capabilities to the maximum potential for integrating data. In this review we discuss the architecture, design and key technologies underlying some of the prominent databases (DBs and web applications. We will mention their roles in integration of biological data and investigate some of the emerging design concepts and computational technologies that are likely to have a key role in the future of systems driven biomedical research.

  14. Current exposure to persistent polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (p,p'-DDE) of Belgian students from food and dust.

    Science.gov (United States)

    Roosens, Laurence; Abdallah, Mohamed Abou-Elwafa; Harrad, Stuart; Neels, Hugo; Covaci, Adrian

    2010-04-15

    Human exposure to individual polychlorinated biphenyl (PCB) congeners and dichloro-diphenyldichloroethylene (p,p'-DDE) through food (duplicate diets) and indoor dust ingestion was assessed for 19 Belgian students. The serum concentrations of the persistent PCB congeners in serum (PCB 118, 138, 153, 170, and 180) have been correlated with the individual intake through food and dust. Dietary intakes of SigmaPCBs ranged between 40 and 204 ng/day (median 133). PCB exposure through dust ingestion ranged between 0.1 and 0.8 ng/day (median 0.3) or 0.3 and 1.7 ng/day (median 0.8), assuming average dust ingestion (20 mg/day) and high dust ingestion rates (50 mg/day), respectively. Dietary intake of p,p'-DDE was comparable to that of PCBs with a range from 21 to 214 ng/day (median 92). The exposure to p,p'-DDE via dust ingestion ranged between 0.02 and 0.43 ng/day (median 0.17) or 0.05 and 1.09 ng/day (median 0.43), assuming average and high dust ingestion rates, respectively. Concentrations measured in blood serum were 28-153 ng/g lipid weight (lw) (median 74) and 32-264 ng/g lw (median 45) for SigmaPCBs and p,p'-DDE, respectively. Serum concentrations in the studied population are slightly lower compared to other European populations. In spite of the uncertainty associated with the dust ingestion rates, food was the predominant exposure pathway for each PCB congener and for p,p'-DDE in the studied population. Food intake contributed more than 99% of the combined PCB intake from food and dust. No significant positive correlations (p > 0.05) were observed between the serum concentrations of PCBs and p,p'-DDE and the total intake through food and dust for each participant. Instead, it is hypothesized that past and episodic higher current intakes are more important determinants of body burden than continuous background exposures at low levels.

  15. Pediatric intracranial aneurysms: current national trends in patient management and treatment.

    Science.gov (United States)

    Vasan, Rohit; Patel, Jaymin; Sweeney, J M; Carpenter, Anne Marie; Downes, Katheryne; Youssef, A Samy; van Loveren, Harry; Agazzi, Siviero

    2013-03-01

    Pediatric intracranial aneurysms constitute a medical disease process with many unique features that present unique challenges in orchestrating their treatment. Conflicts exist in pediatric aneurysm literature as to whether endovascular therapy is equivalent to surgical therapy in assuring durable aneurysm obliteration in this population. The national Healthcare Cost and Utilization Project (HCUP) Kid's Inpatient Dataset was queried using the HCUPnet system. Overall trends in length of stay (LOS), associated charges, and in-hospital deaths were analyzed for both subarachnoid hemorrhage (SAH) and nonruptured aneurysms from 2000 to 2009. Trends in the type of procedure, associated LOS, and charges were analyzed for SAH from 2003 to 2009. A p value aneurysms. Costs of surgery showed a slight increase, while endovascular procedures also rose 50 % from 2006 to 2009. Interestingly, mean length of stay increased for endovascular procedures from 16.5 to 17.2 days and decreased for surgical procedures from 20.4 to 14.7 days (p pediatric subarachnoid hemorrhage have not significantly declined since 1997. Second, in-hospital charges for the management of both ruptured and nonruptured aneurysms rose by over 200 % from 2000 to 2009. Surgical procedures saw a 6 % increase in price, while endovascular procedures sharply rose in costs by 50 %. Finally, endovascular therapy has increased in utilization, while the frequency of surgical therapy has not changed significantly since 2003.

  16. Current trends in the health of children and young people in learning environments

    Directory of Open Access Journals (Sweden)

    Garkusha S.V.

    2013-10-01

    Full Text Available Determined by the dynamics in the health of students and medical teams consisting of physical training in secondary schools. Analyzed the records in-depth inspection of magazines and leaflets health of 32484 schoolchildren of Chernigov for the period 2008-2012. Established a steady trend to a significant deterioration in the health of schoolchildren. A decline in the number of healthy children with the increase in the period of study from 1 to 11. Revealed negative trend decline in the health of children in the main medical group. Shows a tendency to increase the number of children belonging to the preparatory and special medical groups. It is recommended to use a recreational form of physical education and health educational use of technology. It is recommended to include in the training sessions: gymnastics, gymnastic minutes during lessons, exercise, and outdoor games on the elongated recess and daily physical education classes in the extended day, independent study after school, sports and mass work in the community.

  17. Public Debts Trends in the Current Economic Context, from Both National and International Perspective

    Directory of Open Access Journals (Sweden)

    Doina Dascalu

    2015-12-01

    Full Text Available . The article presents an analysis of the way public debt operates in Romania, in the context of states economies trends, of complex and topical financial environments. In the context of a functional market economy, the issues faced by certain states involving high public debt levels or potential budgetary pressure risks converge towards the idea that public finances sustainability needs to be a major challenge at the level of public policies. Considering this situation, the adequate policies to tackle public finances sustainability need to have, as a launching base, the overall strategy of the European Union, focused on the three component parts, namely abatement of public debt, increasing productivity and employment and last but not least, reforming the pension and healthcare systems. To ensure reasonably sustainable public debt levels, EU member states need to attain medium term strategic budgetary objectives, that would ensure a downward trend of public debt, a condition which can be fulfilled by compliance with budget policies rules, which ground development in the macroeconomic framework.

  18. Current trends in diagnostic and therapeutic principles for prostate cancer in Japan.

    Science.gov (United States)

    Okihara, Koji; Shiraishi, Takumi; Ukimura, Osamu; Mizutani, Yoichi; Kawauchi, Akihiro; Miki, Tsuneharu

    2008-06-01

    This study aimed to clarify characteristics of the diagnosis and treatment of prostate cancer in Japan. In September 2005, questionnaire surveys were mailed to Japanese urologists (response rate, 43%; 474/1090) who were listed as voting members (VMs) of the Japanese Urological Association (JUA); the questionnaire surveys were also mailed to professors and chairmen (PCs) of urology departments at Japanese national, public, and private universities who were also VMs of the JUA (response rate, 76%; 68/90). The questionnaires asked about beliefs and practices regarding prostate cancer management. The answers of the VMs and PCs to the questionnaire were very similar. About 60% of these urologists answered that they did not set an age limit for prostate-specific antigen (PSA) testing, and about 40% answered that they did not set an age limit for prostate needle biopsy in individuals with an intermediately elevated PSA level. The age limit for radical prostatectomy (RP) was set at 75 years by 69% (322/470) of the VMs and 66% (45/68) of the PCs. The order of priority of factors considered for the selection of RP for early prostate cancer was radicality, including tumor grade (mean, 1.97); patient's wish for radical surgery (mean, 2.47); comorbidity (mean, 2.72); and age (mean, 2.81). There are trends in diagnostic and therapeutic principles for prostate cancer which are characteristic of Japan, and these trends are associated with the recent rapid extension of life expectancy in that country.

  19. Language Play and Linguistic Hybridity as Current Trends in Hungarian Word-Formation

    Directory of Open Access Journals (Sweden)

    Réka Benczes

    2016-01-01

    Full Text Available Hungarian literature on word-formation typically focuses on rule-governed descriptions of regular and typologically relevant patterns. However, there are plenty of other word-formation trends that usually go unnoticed in mainstream morphological research. The present paper will focus on two such trends: 1 rhyming and alliterating compounds such as pannon puma ‘Pannonian puma’ (a euphemism for Hungary’s economic performance, on the analogy of Asian tiger; and 2 creative prefixations such as meggugliz (‘to google’ and felhájpol (‘to hype’. Although these are seemingly two quite different patterns, in fact they share two significant traits. On the one hand, they are demonstrations of the fact that language users make full use of the creative possibilities in language and routinely play with sounds and meanings. On the other hand, they are also indications of the influential role of English in present-day Hungarian word-formation. It seems that language users are not only aware of the possibilities that this interference can result in but are also able to exploit these consciously. This crossing of language boundaries is becoming increasingly inevitable with the global spread of English.

  20. An overview of RDF processing systems: Current status, design features, and future trends

    Energy Technology Data Exchange (ETDEWEB)

    Ohlsson, O.O. (Argonne National Lab., IL (United States)); Walter, D.K. (USDOE Assistant Secretary for Conservation and Renewable Energy, Washington, DC (United States). Waste Material Management Div.); Goodman, B.J. (Solar Energy Research Inst., Golden, CO (United States))

    1991-01-01

    This paper discusses the recent history of refuse-derived fuel (RDF) processing facilities in the United States. The current status of these facilities, including environmental, institutional, and economic considerations is discussed. The unit operations used to produce a desired RDF product are described, and the future potential of RDF processing systems is evaluated. Current research sponsored by the US Department of Energy is also presented. 6 refs., 3 figs., 8 tabs.

  1. The Diagnosis and Hemodynamic Monitoring of Circulatory Shock: Current and Future Trends

    Directory of Open Access Journals (Sweden)

    Hendy Adham

    2016-07-01

    Full Text Available Circulatory shock is a complex clinical syndrome encompassing a group of conditions that can arise from different etiologies and presented by several different hemodynamic patterns. If not corrected, cell dysfunction, irreversible multiple organ insufficiency, and death may occur. The four basic types of shock, hypovolemic, cardiogenic, obstructive and distributive, have features similar to that of hemodynamic shock. It is therefore essential, when monitoring hemodynamic shock, to making accurate clinical assessments which will guide and dictate appropriate management therapy. The European Society of Intensive Care has recently made recommendations for monitoring hemodynamic shock. The present paper discusses the issues raised in the new statements, including individualization of blood pressure targets, prediction of fluid responsiveness, and the use of echocardiography as the first means during the initial evaluation of circulatory shock. Also, the place of more invasive hemodynamic monitoring techniques and future trends in hemodynamic and metabolic monitoring in circulatory shock, will be debated.

  2. Current status and trends of wheat genetic transformation studies in China

    Institute of Scientific and Technical Information of China (English)

    HE Yi; WANG Qiong; ZENG Jian; SUN Tao; YANG Guang-xiao; HE Guang-yuan

    2015-01-01

    More than 20 years have passed since the ifrst report on successful genetic transformation of wheat. With the establishment and improvement of transformation platform, great progresses have been made on wheat genetic transformation both on its fundamental and applied studies in China, especial y driven by the National Major Project for Transgenic Organism Breed-ing, China, initiated in 2008. In this review, wheat genetic transformation platform improvement and transgenic research progresses including new techniques applied and functional studies of wheat quality, yield and stress tolerant related genes and biosafety assessment are summarized. The existing problems and the trends in wheat transformation with traditional methods combined with genomic studies and genome editing technology are also discussed.

  3. Current state and development trends of the agroindustrial complex and rural territories of Perm Region

    Directory of Open Access Journals (Sweden)

    Gennadiy Vladimirovich Klimenkov

    2011-12-01

    Full Text Available Analysis of regional agricultural sector status and rural areas of Perm in 1990-2011 years indicates a systemic crisis of agriculture in Perm region, which is largely determined by the fact that Perm region has no strategy or strategic plan and program for sustainable agricultural sector and rural areas of Perm region development, there is no scheme of territorial development and master plans of territorial development with the development of agro-industrial complex of Perm region. In these circumstances, there is a steady downward trend in production, weakening and bankruptcy of enterprises, social impoverishment of rural areas, appearance of many of irreversible processes (sale and neglect of agricultural land, demographic problems associated with low living standards, population migration, policy optimization in the areas of education and health, union of territories, policy of depopulation of territories etc.. This paper presents main recommendations for improving the situation in agriculture of Perm region.

  4. Return of the "intimate outsider": current trends and issues in family nursing research revisited.

    Science.gov (United States)

    Ganong, Lawrence

    2011-11-01

    This article reviews family nursing research published from 1996 to 2011. This is a follow-up to a review published in the Journal of Family Nursing in 1995. Findings from the first review are compared with this one, trends in family nursing scholarship are identified, and predictions and suggestions for future directions are offered. The latest generation of family nursing scholarship is conceptually and methodologically sound, and there is evidence of more multidisciplinary and interdisciplinary research conducted by family nursing researchers. Scholars are paying more attention to issues of diversity and family context at present than in the past, although there are still aspects of diversity that need more attention. Strong research programs in family nursing exist worldwide; an international synergism has helped promote rapid expansion of family nursing research and theory development. A vigorous movement to promote research to practice initiatives and greater attention to family interventions are exciting developments.

  5. Levels and temporal trends of persistent organic pollutants (POPs) in arctic foxes (Vulpes lagopus) from Svalbard in relation to dietary habits and food availability

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, Martin S. [Norwegian Polar Institute, Fram Centre, NO-9296 Tromsø (Norway); Department of Arctic and Marine Biology, UiT The Arctic University of Norway, NO-9037 Tromsø (Norway); Fuglei, Eva; König, Max [Norwegian Polar Institute, Fram Centre, NO-9296 Tromsø (Norway); Lipasti, Inka [Department of Biology, University of Eastern Finland, FI-80101 Joensuu (Finland); Pedersen, Åshild Ø. [Norwegian Polar Institute, Fram Centre, NO-9296 Tromsø (Norway); Polder, Anuschka [Department of Food Safety and Infection Biology, Norwegian University of Life Sciences, P.O. Box 5003, NO-1432 Ås (Norway); Yoccoz, Nigel G. [Department of Arctic and Marine Biology, UiT The Arctic University of Norway, NO-9037 Tromsø (Norway); Routti, Heli, E-mail: heli.routti@npolar.no [Norwegian Polar Institute, Fram Centre, NO-9296 Tromsø (Norway)

    2015-04-01

    Temporal trends of persistent organic pollutants (POPs) in arctic foxes (Vulpes lagopus) from Svalbard, Norway, were investigated in relation to feeding habits and seasonal food availability. Arctic foxes from Svalbard forage in both marine and terrestrial ecosystems and the availability of their food items are impacted by climatic variability. Concentrations of polychlorinated biphenyls (PCBs), organochlorinated pesticides (OCPs) and brominated flame retardants (polybrominated diphenyl ethers [PBDEs] and hexabromocyclododecane [HBCDD]) were analyzed in the liver of 141 arctic foxes collected between 1997 and 2013. Stable carbon isotope values (δ{sup 13}C) were used as a proxy for feeding on marine versus terrestrial prey. The annual number of recovered reindeer carcasses and sea ice cover were used as proxies for climate influenced food availability (reindeers, seals). Linear models revealed that concentrations of PCBs, chlordanes, p,p′-DDE, mirex and PBDEs decreased 4–11% per year, while no trends were observed for hexachlorobenzene (HCB) or β-hexachlorocyclohexane (β-HCH). Positive relationships between POP concentrations and δ{sup 13}C indicate that concentrations of all compounds increase with increasing marine dietary input. Increasing reindeer mortality was related to lower HCB concentrations in the foxes based on the linear models. This suggests that concentrations of HCB in arctic foxes may be influenced by high mortality levels of Svalbard reindeer. Further, β-HCH concentrations showed a positive association with sea ice cover. These results in addition to the strong effect of δ{sup 13}C on all POP concentrations suggest that climate-related changes in arctic fox diet are likely to influence contaminant concentrations in arctic foxes from Svalbard. - Highlights: • POPs were analyzed in the arctic foxes' liver (n = 141) from Svalbard collected in 1997–2013. • PCBs, chlordanes, p,p′-DDE, mirex and PBDEs decreased 4–11% per year.

  6. Persistent currents in mesoscopic graphene rings with armchair edges%扶手椅型石墨烯介观环中的持续电流∗

    Institute of Scientific and Technical Information of China (English)

    代楠; 邓文基

    2015-01-01

    Based on the tight-binding model, the energy spectrum and persistent currents of mesoscopic graphene rings with armchair edges are studied analytically and numerically. Characters of the persistent currents changing with Aharonov-Bohm (A-B) magnetic flux in rings in different geometry are investigated in datail. The periodicity and special symmetry of energy spectrum and persistent currents changing with the magnetic flux are revealed. It is demonstrated that the persistent currents are determined by the geometric structures of the rings;the quantum states with small eigen-energies may carry much larger currents than those quantum states with eigen-energies far away from zero.%在紧束缚近似下,解析求解了扶手椅型边界石墨烯介观环的能量本征值问题,计算和讨论了不同大小尺寸的介观环中持续电流随Aharonov-Bohm (A-B)磁通的变化,并证明了能级和持续电流关于磁通变化的周期性和特殊对称性。研究表明,持续电流显著地依赖于介观环的几何结构;零能量附近的能级可以承载较大的持续电流,而远离零能量的其他能级对持续电流的贡献很小。

  7. Temporal trends of persistent organic pollutants in dated sediment cores: Chemical fingerprinting of the anthropogenic impacts in the Seine River basin, Paris.

    Science.gov (United States)

    Lorgeoux, C; Moilleron, R; Gasperi, J; Ayrault, S; Bonté, P; Lefèvre, I; Tassin, B

    2016-01-15

    Persistent organic pollutants (POPs) were extensively produced and used throughout the last century. In the early 1980s, a rising concern on the environmental impact of these chemicals has led to the establishment of regulations and changes of use including bans. Long term monitoring of the environmental impacts of these emissions and regulations is a challenge because regular monitoring was not mandatory at the beginning of the first emissions. Moreover, the analytical methods have been strongly improved over the decades. To overcome the lack of monitoring and accurate data, sediment cores are powerful tools to construct contamination records. In this study, a high resolution record was constructed for four POPs families (13 polycyclic aromatic hydrocarbons (PAHs), 15 polychlorinated biphenyls (PCBs), 3 alkylphenols (APs) and 8 polybromodiphenyl ethers (PBDEs)) to establish their historical trends in a long-term urbanized and industrialized environment: the Seine River basin, France. These specific families were selected because they had different sources, uses and histories. The results showed concentrations up to 90 mg/kg for ∑PAHs, 2.3mg/kg for ∑PCB, 1.2mg/kg for ∑APs and 0.06 mg/kg for ∑PBDE. The vertical distribution profiles were different from one family to another and presented a good correlation with uses (e.g. transition from coal to natural gas for PAHs), and regulation implementation (e.g., AP ban after "OSPAR Convention" in 1992). The study of compounds distribution provided original information on sources, e.g. temporal variations in PAH uses. This study demonstrates the usefulness and accuracy of sedimentary archives in floodplain to assess the fate of POPs through time in continental hydrosystems. These first results give a comprehensive overview of the contamination in the Seine River basin downstream of Paris Megacity. They were in good agreement with previous studies dedicated to European areas and highlighted specificities of this basin

  8. Current Concepts and New Trends in the Treatment of Cardiogenic Shock Complicating Acute Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Benedek Theodora

    2015-03-01

    Full Text Available Cardiogenic shock (CS is a critical condition which often complicates the evolution of an acute myocardial infarction (AMI. At the same time, co-existence of chronic multi-vessel disease can lead to the development of cardiogenic shock in cases with pronounced haemodynamic instability. Different clinical studies have tried to identify the most appropriate treatment for critical cases of CS complicating AMI. This review aims to present the current status of recommended therapeutic strategies for severe cases of CS presenting as a complication of AMI, and try to shed light on the most appropriate therapeutic strategy as outlined in the current literature. The paper will discuss the different current strategies available for use in the treatment of this condition, includig interventional revascularisation, (complete or culprit, the role of new devices for providing mechanical circulatory support, and the potential role of new drug therapies and of hypothermia.

  9. Lifelong Education for Older Adults in Malta: Current Trends and Future Visions

    Science.gov (United States)

    Formosa, Marvin

    2012-01-01

    With European demographic developments causing a decline of the available workforce in the foreseeable future and the unsustainability of dominant pay-as-you-go pension systems (where contributions from the current workforce sustain pensioners), governments need to come up with strategies to deal with this upcoming challenge and to adjust their…

  10. The Development of Professional Counseling in Uganda: Current Status and Future Trends

    Science.gov (United States)

    Senyonyi, Ruth M.; Ochieng, Lois A.; Sells, James

    2012-01-01

    Professional counseling in Uganda has foundations in traditional cultures of its peoples, guidance offered in schools, and counseling to curb the HIV/AIDS epidemic. Currently, a definitive professional counselor profile in Uganda is being established. The Uganda Counselling Association continues the process of seeking legal authority to regulate…

  11. ORGAN-SPARING SURGERY FOR RECTAL CANCER: EVOLUTION, CURRENT TRENDS, AND PROSPECTS

    Directory of Open Access Journals (Sweden)

    R. I. Tamrazov

    2013-01-01

    Full Text Available The article describes the main stages of the development of sphincter-saving surgery for rectal cancer. An historical look at this issue from the standpoint of research of past years in our country and abroad, as well as analysis of current sphincter-preserving surgery and future directions in this area.

  12. Biobased adhesives, gums, emulsions and binders: current trends and future prospects

    Science.gov (United States)

    Biopolymers derived from renewable resources are an emerging class of advanced materials that offer many useful properties for a wide range of food and non-food applications. Current state of the art in research and development of renewable polymers as adhesives, gums, binders and emulsions will be ...

  13. Current Technology Trends and Issues among Health and Physical Education Professionals

    Science.gov (United States)

    Krause, Jennifer M.; Franks, Hillary; Lynch, Brandy

    2017-01-01

    Health and physical education professionals who implement technology appropriately can contribute to helping students become physically educated individuals (NASPE, 2009). It is imperative that professionals be knowledgeable and resourceful in how to integrate technology effectively, but it is unclear what current challenges professionals face in…

  14. Current Trends in Environmental Education in the French-Speaking Areas of Belgium.

    Science.gov (United States)

    Goffin, Louis

    1991-01-01

    The current status of environmental education in French-speaking Belgium is described, with attention given to the development of environmental interest and awareness, the evolution of an environmental education information dissemination network, other governmental and nongovernmental groups involved, school syllabuses, teacher training…

  15. Current research trends and perspectives on materials-based hydrogen storage solutions: A critical review

    CSIR Research Space (South Africa)

    Ren, Jianwei

    2016-01-01

    Full Text Available Effective hydrogen storage solutions have been pursued for decades, and materials-based hydrogen storage is a research frontier of much current interest. Yet, no researched materials to date have come close to the DOE 2020 targets for hydrogen...

  16. Prevention of voice prosthesis biofilms: current scenario and future trends in prolonging prosthesis lifetime.

    Science.gov (United States)

    Sayed, Sushail I; Datta, Sourav; Deore, Nitin; Kazi, Rehan A; Jagade, Mohan V

    2012-03-01

    Voice rehabilitation after a total laryngectomy is an important requisite for patients' rehabilitation. Oesophageal speech using tracheo-oesophageal-valved prostheses is now considered the state-of-art in postlaryngectomy voice rehabilitation. One of the major drawbacks of voice prostheses is their limited device lifetime. This is due to the deterioration of the silicone rubber material by different bacterial and yeast species, which are organised in the form of a biofilm resulting in internal leakage, increased airflow resistance, impeding speech, respiration and swallowing. The use of antimicrobials though easily applicable is associated with development of resistance if used on long-term basis. Other techniques in the form of modification of physicochemical properties of the silicon surface or covalent binding of antimicrobial agents to the silicon surface have been employed. This article reviews the different strategies investigated until now and the future trends in preventing biofilm formation for prolonging the lifetime of the silicon voice prostheses. Data was collected by conducting a computer aided search of the MED-LINE and PUBMED databases, supplemented by hand searches of key journals. Over 35 articles in the last two decades on the topic have been reviewed out of which 27 were found to be of relevant value for this article.

  17. Environmental radioactivity measurements and applications - Difficulties, current status and future trends

    Science.gov (United States)

    Anagnostakis, Marios J.

    2015-11-01

    For several decades natural and artificial radioactivity in the environment have been extensively studied all around the world. Nuclear accidents - mainly that of Chernobyl - have led to the development of the field of radioecology, while detector systems and techniques - with predominant that of γ-spectrometry - have been continuously developed through the years to meet researchers' needs. The study of natural radionuclides that was originally limited to 226Ra, 232Th and 40K was then extended to include radionuclides such as 234Th, 210Pb, 235U and 7Be, which allowed the study of radioactive equilibrium. Besides their importance from the radiation protection point of view, many radionuclides are also used as tracers of environmental processes, such as aerosol and transportation of air masses studies (7Be, 10Be, 22Na), soil erosion, sedimentation and geochronology (210Pb, 137Cs), marine ecosystems studies and studies related to climate change. All these studies require specialized samplings strategies and sampling preparation techniques as well as high quality measurements, while the improvement of detection limits is often of vital importance. This work is a review of environmental radioactivity measurements and applications, mainly focused in the field of γ-spectrometry, for which difficulties and limitations will be presented, together with future trends, new challenges and applications.

  18. High Override Rate for Opioid Drug-allergy Interaction Alerts: Current Trends and Recommendations for Future.

    Science.gov (United States)

    Topaz, Maxim; Seger, Diane L; Lai, Kenneth; Wickner, Paige G; Goss, Foster; Dhopeshwarkar, Neil; Chang, Frank; Bates, David W; Zhou, Li

    2015-01-01

    This study examined trends in drug-allergy interaction (DAI) alert overrides for opioid medications - the most commonly triggered alerts in the computerized provider order entry (CPOE). We conducted an observational analysis of the DAI opioid alerts triggered over the last decade (2004-2013, n=342,338) in two large academic hospitals in Boston (United States). We found an increasing rate of DAI alert overrides culminating in 89.7% in 2013. Allergic reactions included a high proportion (38.2%) of non-immune mediated opioid reactions (e.g. gastrointestinal upset). The DAI alert override rate was high for immune mediated (88.6%) and life threatening reactions (87.8%). Exact allergy-medication matches were overridden less frequently (about 70%) compared to non-exact matches within allergy groups (over 90%). About one-third of the alert override reasons pointed to irrelevant alerts (i.e."Patient has tolerated the medication before") and 44.9% were unknown. Those findings warrant further investigation into providers' reasons for high override rate. User interfaces should evolve to enable less interruptive and more accurate alerts to decrease alert fatigue.

  19. Ten years after "Worrying trends in econophysics": developments and current challenges

    Science.gov (United States)

    Ormerod, Paul

    2016-12-01

    Econophysics has made a number of important additions to scientific knowledge. Yet it continues to lack influence with both economists and policy makers. Ten years ago, I and three other economists sympathetic to econophysics wrote a paper on worrying trends within the discipline. For example, its lack of awareness of the economics literature, and shortfalls in the use of statistical analysis. These continue to be obstacles to wider acceptance by economists. Like all agents, policy makers respond to incentives, and economists understand this very well. Much of the econophysics community appears to think that simply doing good science is sufficient to have the work recognised, rather than relating to the motivations and incentives of policy makers. Nevertheless, econophysics now has three major opportunities to advance knowledge in areas where policy makers perceive weaknesses in what they are presented with by economists. All can benefit from the analysis of Big Data. The first is a core model of agent behaviour which is more relevant to cyber society than the rational agent model of economics. Second, extending our understanding of the business cycle, primarily by incorporating the importance of networks into models. Third, devising proper measures of output in cyber society.

  20. Otolaryngology in the medical school curriculum: Current trends in the United States.

    Science.gov (United States)

    Boscoe, Elizabeth F; Cabrera-Muffly, Cristina

    2017-02-01

    To identify trends in medical school otolaryngology curriculum requirements. Survey of United States allopathic medical schools. A survey was sent to deans of curriculum at allopathic medical schools. We identified opportunities for medical students to learn basic concepts in otolaryngology during their undergraduate medical training. The opportunities were classified into preclinical and clinical as well as elective and mandatory rotations. Of the schools surveyed, 60% responded. Mean class size was 149 students. Sixty-eight percent of surveyed schools noted that 75% to 100% of their students participated in preclinical otolaryngology experiences, with 59% reporting a mandatory preclinical otolaryngology module for all students. Eighty-nine percent of schools offered otolaryngology as a clinical elective rotation, with a mean of 12 students participating yearly. Only 7% of schools required a mandatory otolaryngology clinical rotation. Our data suggest that medical students do not receive sufficient exposure to otolaryngology during medical school. Increased requirements for otolaryngology curriculum may be beneficial to all medical students, regardless of their specialty choice. NA. Laryngoscope, 00:000-000, 2016 127:346-348, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  1. The incidence of induced abortion in the Philippines: current level and recent trends.

    Science.gov (United States)

    Juarez, Fatima; Cabigon, Josefina; Singh, Susheela; Hussain, Rubina

    2005-09-01

    In the Philippines, abortion is legally restricted. Nevertheless, many women obtain abortions--often in unsafe conditions--to avoid unplanned births. In 1994, the estimated abortion rate was 25 per 1,000 women per year; no further research on abortion incidence has been conducted in the Philippines. Data from 1,658 hospitals were used to estimate abortion incidence in 2000 and to assess trends between 1994 and 2000, nationally and by region. An indirect estimation methodology was used to calculate the total number of women hospitalized for complications of induced abortion in 2000 (averaged data for 1999-2001), the total number of women having abortions and the rate of induced abortion. In 2000, an estimated 78,900 women were hospitalized for postabortion care, 473,400 women had abortions and the abortion rate was 27 per 1,000 women aged 15-44 per year. The national abortion rate changed little between 1994 and 2000; however, large increases occurred in metropolitan Manila (from 41 to 52) and Visayas (from 11 to 17). The proportions of unplanned births and unintended pregnancies increased substantially in Manila, and the use of traditional contraceptive methods increased in Manila and Visayas. The increase in the level of induced abortion seen in some areas may reflect the difficulties women experience in obtaining modern contraceptives as a result of social and political constraints that affect health care provision. Policies and programs regarding both postabortion care and contraceptive services need improvement.

  2. Acromioclavicular dislocation: treatment and rehabilitation. Current perspectives and trends among Brazilian orthopedists.

    Science.gov (United States)

    Arliani, Gustavo Gonçalves; Utino, Artur Yudi; Nishimura, Eduardo Misao; Terra, Bernardo Barcellos; Belangero, Paulo Santoro; Astur, Diego Costa

    2015-01-01

    To evaluate the approaches and procedures used by Brazilian orthopedic surgeons in treatment and rehabilitation of acromioclavicular dislocation of the shoulder. A questionnaire comprising eight closed questions that addressed topics relating to treatment and rehabilitation of acromioclavicular dislocation was applied to Brazilian orthopedic surgeons over the three days of the 45th Brazilian Congress of Orthopedics and Traumatology, in 2013. A total of 122 surgeons completely filled out the questionnaire and formed part of the sample analyzed. Most of them came from the southeastern region of the country. In this sample, 67% of the participants would choose surgical treatment for patients with grade 3 acromioclavicular dislocation. Regarding the preferred technique for surgical treatment of acute acromioclavicular dislocation, a majority of the surgeons used subcoracoid ligature with acromioclavicular fixation and transfer of the coracoacromial ligament (25.4%). Regarding complications found after surgery had been performed, 43.4% and 32.8% of the participants, respectively, stated that residual deformity of the operated joint and pain were the complications most seen during the postoperative period. Although there was no consensus regarding the treatment and rehabilitation of acromioclavicular dislocation, evolution had occurred in some of the topics analyzed in this questionnaire applied to Brazilian orthopedists. However, further controlled prospective studies are needed in order to evaluate the clinical and scientific benefit of these trends.

  3. Acromioclavicular dislocation: treatment and rehabilitation. Current perspectives and trends among Brazilian orthopedists☆

    Science.gov (United States)

    Arliani, Gustavo Gonçalves; Utino, Artur Yudi; Nishimura, Eduardo Misao; Terra, Bernardo Barcellos; Belangero, Paulo Santoro; Astur, Diego Costa

    2015-01-01

    Objective To evaluate the approaches and procedures used by Brazilian orthopedic surgeons in treatment and rehabilitation of acromioclavicular dislocation of the shoulder. Methods A questionnaire comprising eight closed questions that addressed topics relating to treatment and rehabilitation of acromioclavicular dislocation was applied to Brazilian orthopedic surgeons over the three days of the 45th Brazilian Congress of Orthopedics and Traumatology, in 2013. Results A total of 122 surgeons completely filled out the questionnaire and formed part of the sample analyzed. Most of them came from the southeastern region of the country. In this sample, 67% of the participants would choose surgical treatment for patients with grade 3 acromioclavicular dislocation. Regarding the preferred technique for surgical treatment of acute acromioclavicular dislocation, a majority of the surgeons used subcoracoid ligature with acromioclavicular fixation and transfer of the coracoacromial ligament (25.4%). Regarding complications found after surgery had been performed, 43.4% and 32.8% of the participants, respectively, stated that residual deformity of the operated joint and pain were the complications most seen during the postoperative period. Conclusions Although there was no consensus regarding the treatment and rehabilitation of acromioclavicular dislocation, evolution had occurred in some of the topics analyzed in this questionnaire applied to Brazilian orthopedists. However, further controlled prospective studies are needed in order to evaluate the clinical and scientific benefit of these trends. PMID:26535196

  4. Current trends in the empirical study of cognitive remediation for schizophrenia.

    Science.gov (United States)

    Saperstein, Alice M; Kurtz, Matthew M

    2013-06-01

    Cognitive remediation (CR) for schizophrenia is a learning-based behavioural skills training intervention designed to enhance neuro and (or) social cognitive skills, with the ultimate goal of generalization to improve psychosocial outcomes. This review summarizes conceptual approaches to CR for schizophrenia and the evidence for efficacy in clinical research settings. Four issues are at the forefront of ongoing research: the identification of techniques that produce the largest cognitive change, delineation of techniques that enhance transfer of cognitive skills to functional skills, the identification of CR methods that can be personalized to meet the specific cognitive and functional needs of each individual, and, all the while, ensuring that when CR methods are developed in a research setting, they remain scalable for delivery in the larger clinical community. In response to these issues, 3 prominent research trends have emerged: the rise of a new generation of computerized restorative cognitive training, the integration of CR with skills training to promote generalization, and the application of techniques to enhance motivation and learning during CR. As data on the neural basis of learning in people with schizophrenia become available, new technologies that harness the ability of the brain to make sustainable, functional changes may be integrated within a therapeutic context that promotes a personalized approach to learning. The development of transportable and scalable methods of CR that maximize the ability of people with schizophrenia to improve cognition will help them achieve personal goals for recovery.

  5. Recent trends for practical rehabilitation robotics, current challenges and the future.

    Science.gov (United States)

    Yakub, Fitri; Md Khudzari, Ahmad Zahran; Mori, Yasuchika

    2014-03-01

    This paper presents and studies various selected literature primarily from conference proceedings, journals and clinical tests of the robotic, mechatronics, neurology and biomedical engineering of rehabilitation robotic systems. The present paper focuses of three main categories: types of rehabilitation robots, key technologies with current issues and future challenges. Literature on fundamental research with some examples from commercialized robots and new robot development projects related to rehabilitation are introduced. Most of the commercialized robots presented in this paper are well known especially to robotics engineers and scholars in the robotic field, but are less known to humanities scholars. The field of rehabilitation robot research is expanding; in light of this, some of the current issues and future challenges in rehabilitation robot engineering are recalled, examined and clarified with future directions. This paper is concluded with some recommendations with respect to rehabilitation robots.

  6. Current trends in research and clinical issues in the study of personality and its disorders

    DEFF Research Database (Denmark)

    Simonsen, Erik; Sørensen, Per; Pedersen, Liselotte

    2014-01-01

    lecture (Simonsen), a young researchers' symposium (Hopwood, Sharp, and Kaess), and special lectures on the Danish philosopher Soeren Kierkegaard and the poet Hans Christian Andersen. In this article we will survey the presentations and highlight the important issues in order to underline the current......The International Society for the Study of Personality Disorders (ISSPD) celebrated its 25th anniversary in September 2013 in Copenhagen and commemorated the First International Congress at the same site. The overall theme of the congress was "Bridging Personality and Psychopathology: The Person...... Behind the Illness." More than 400 abstracts were submitted, and the program included 8 keynote presentations, 18 invited symposia, a debate on current controversial issues in the classification of personality disorders (Fossati, Tyrer, Livesley, and Krueger), an ISSPD award lecture (Silk), a jubilee...

  7. Regeneration of tissues of the oral complex: current clinical trends and research advances.

    Science.gov (United States)

    Nguyen, Thomas T; Mui, Brennan; Mehrabzadeh, Mahsa; Chea, Yannie; Chaudhry, Zoya; Chaudhry, Kamran; Tran, Simon D

    2013-01-01

    Regenerative therapy in oral health care is limited by both the body's natural capacity for regeneration and the materials and methods currently available. Research on various aspects of regenerative therapy, such as tissue engineering and stem cell and gene therapy, has produced promising results. Compelling advances, ranging from the discovery and characterization of stem cell populations in oral tissue to the engineering and transplantation of whole tooth structures, could result in exciting new treatment methods for clinicians in the near future. In this review, we discuss the limitations of natural healing and regeneration of various tissues of the oral complex, including teeth, periodontium and salivary glands, and summarize current treatment methods for tissue damage as well as research advances in oral tissue regeneration.

  8. Variability and trends of ocean acidification in the Southern California Current System: A time series from Santa Monica Bay

    Science.gov (United States)

    Leinweber, A.; Gruber, N.

    2013-07-01

    We investigate the temporal variability and trends of pH and of the aragonite saturation state, Ωarag, in the southern California Current System on the basis of a 6 year time series from Santa Monica Bay, using biweekly observations of dissolved inorganic carbon and combined calculated and measured alkalinity. Median values of pH and Ωarag in the upper 20 m are comparable to observations from the subtropical gyres, but the temporal variability is at least a factor of 5 larger, primarily driven by short-term upwelling events and mesoscale processes. Ωarag and pH decrease rapidly with depth, such that the saturation horizon is reached already at 130 m, on average, but it occasionally shoals to as low as 30 m. No statistically significant linear trends emerge in the upper 100 m, but Ωarag and pH decrease, on average, at rates of -0.009±0.006 yr-1 and -0.004±0.003 yr-1 in the 100-250 m depth range. These are somewhat larger, but not statistically different from the expected trends based on the recent increase in atmospheric CO2. About half of the variability in the deseasonalized data can be explained by the El Niño Southern Oscillation, with warm phases (El Niño) being associated with above normal pH and Ωarag. The observed variability and trend in Ωarag and pH is well captured by a multiple linear regression model on the basis of a small number of readily observable independent variables. This permits the estimation of these variables for related sites in the region.

  9. Plastics, the environment and human health: current consensus and future trends

    OpenAIRE

    Richard C. Thompson; Moore, Charles J.; Frederick S Vom Saal; Swan, Shanna H.

    2009-01-01

    Plastics have transformed everyday life; usage is increasing and annual production is likely to exceed 300 million tonnes by 2010. In this concluding paper to the Theme Issue on Plastics, the Environment and Human Health, we synthesize current understanding of the benefits and concerns surrounding the use of plastics and look to future priorities, challenges and opportunities. It is evident that plastics bring many societal benefits and offer future technological and medical advances. However...

  10. Mercury Content of Sediments in East Fork Poplar Creek: Current Assessment and Past Trends

    Energy Technology Data Exchange (ETDEWEB)

    Brooks, Scott C [ORNL; Eller, Virginia A [ORNL; Dickson, Johnbull O [ORNL; Earles, Jennifer E [ORNL; Lowe, Kenneth Alan [ORNL; Mehlhorn, Tonia L [ORNL; Olsen, Todd A [ORNL; DeRolph, Christopher R [ORNL; Watson, David J [ORNL; Phillips, Debra H [Queen’s University Belfast, UK; Peterson, Mark J [ORNL

    2017-01-01

    This study provided new information on sediment Hg and MMHg content and chemistry. The results support the relevance and potential impacts of other active and planned investigations within the TD project (e.g., assessment and control of bank soil inputs, sorbents for Hg and MMHg removal, re-introduction of freshwater clams to EFPC) and identify gaps in current understanding that represent opportunities to understand controlling variables that may inform future technology development studies.

  11. Mapping a landscape of learning design: Identifying key trends in current practice at the Open University

    OpenAIRE

    Cross, Simon; Conole, Grainne; Clark, Paul; Brasher, Andrew; Weller, Martin

    2008-01-01

    The object of this paper is to present some early analysis of interview and focus group data about how existing teacher educators at The Open University (UK) approach, understand, and deploy learning design and the additional support and tools they would find helpful. This represents a component of a broader institutional project that seeks to develop a learning design tool for the support and promotion of learning design and to better define the current landscape of learning design across th...

  12. Dynamo Models of the Solar Cycle: Current Trends and Future Prospects

    CERN Document Server

    Nandy, Dibyendu

    2011-01-01

    The magnetic cycle of the Sun, as manifested in the cyclic appearance of sunspots, significantly influences our space environment and space-based technologies by generating what is now termed as space weather. Long-term variation in the Sun's magnetic output also influences planetary atmospheres and climate through modulation of solar irradiance. Here, I summarize the current state of understanding of this magnetic cycle, highlighting important observational constraints, detailing the kinematic dynamo modeling approach and commenting on future prospects.

  13. Plastics, the environment and human health: current consensus and future trends

    OpenAIRE

    Thompson, Richard C.; Moore, Charles J.; vom Saal, Frederick S.; Swan, Shanna H.

    2009-01-01

    Plastics have transformed everyday life; usage is increasing and annual production is likely to exceed 300 million tonnes by 2010. In this concluding paper to the Theme Issue on Plastics, the Environment and Human Health, we synthesize current understanding of the benefits and concerns surrounding the use of plastics and look to future priorities, challenges and opportunities. It is evident that plastics bring many societal benefits and offer future technological and medical advances. However...

  14. Plastics, the environment and human health: current consensus and future trends.

    Science.gov (United States)

    Thompson, Richard C; Moore, Charles J; vom Saal, Frederick S; Swan, Shanna H

    2009-07-27

    Plastics have transformed everyday life; usage is increasing and annual production is likely to exceed 300 million tonnes by 2010. In this concluding paper to the Theme Issue on Plastics, the Environment and Human Health, we synthesize current understanding of the benefits and concerns surrounding the use of plastics and look to future priorities, challenges and opportunities. It is evident that plastics bring many societal benefits and offer future technological and medical advances. However, concerns about usage and disposal are diverse and include accumulation of waste in landfills and in natural habitats, physical problems for wildlife resulting from ingestion or entanglement in plastic, the leaching of chemicals from plastic products and the potential for plastics to transfer chemicals to wildlife and humans. However, perhaps the most important overriding concern, which is implicit throughout this volume, is that our current usage is not sustainable. Around 4 per cent of world oil production is used as a feedstock to make plastics and a similar amount is used as energy in the process. Yet over a third of current production is used to make items of packaging, which are then rapidly discarded. Given our declining reserves of fossil fuels, and finite capacity for disposal of waste to landfill, this linear use of hydrocarbons, via packaging and other short-lived applications of plastic, is simply not sustainable. There are solutions, including material reduction, design for end-of-life recyclability, increased recycling capacity, development of bio-based feedstocks, strategies to reduce littering, the application of green chemistry life-cycle analyses and revised risk assessment approaches. Such measures will be most effective through the combined actions of the public, industry, scientists and policymakers. There is some urgency, as the quantity of plastics produced in the first 10 years of the current century is likely to approach the quantity produced in the

  15. Monitoring Current Status of and Trends in Boreal Forest Land Use in Russian Karelia

    Directory of Open Access Journals (Sweden)

    Erkki Tomppo

    2003-12-01

    Full Text Available Some of the last remaining near-natural boreal forest landscapes in northern Europe can be found in the Russian Karelia near its border with Finland. Currently, these forests are facing strong exploitation pressure in the form of extensive clearcuts. Demand for conservation is also high. We characterize the boreal forest landscape in the region and assess the impacts of past and potential management actions through a mapping and modeling study that synthesizes methods from landscape ecology, remote sensing, and simulation modeling. The forests of the study area were mapped using techniques for interpreting multitemporal satellite images and detecting changes. The species composition and structure of the forests were estimated using the multisource k-nearest neighbors (k-nn method. Forest harvesting rates and current landscape patterns were used to parameterize models built with a cell-based Spatially Explicit Landscape Event Simulator (SELES modeling tool, and alternative land-use policy strategies were simulated with and without natural fire. Based on 10 Monte Carlo runs for each scenario, we can predict dramatic changes in the forest landscape structure after 30–70 yr. The current, complexly structured, near-natural forest assemblage will rapidly be converted into its transpose: an expanse of young regeneration stands, with blocks of near-natural forest extant only as islands within mires and in the reserve areas. The prompt establishment of the proposed Kalevala National Park is regionally important for these reasons: (1 to increase the types of near-natural forest conserved, (2 to provide a second large biodiversity source adjacent to the heavily fragmented Finnish forests, and (3 to reduce the currently inflated rate of harvesting.

  16. Plastics, the environment and human health: current consensus and future trends

    Science.gov (United States)

    Thompson, Richard C.; Moore, Charles J.; vom Saal, Frederick S.; Swan, Shanna H.

    2009-01-01

    Plastics have transformed everyday life; usage is increasing and annual production is likely to exceed 300 million tonnes by 2010. In this concluding paper to the Theme Issue on Plastics, the Environment and Human Health, we synthesize current understanding of the benefits and concerns surrounding the use of plastics and look to future priorities, challenges and opportunities. It is evident that plastics bring many societal benefits and offer future technological and medical advances. However, concerns about usage and disposal are diverse and include accumulation of waste in landfills and in natural habitats, physical problems for wildlife resulting from ingestion or entanglement in plastic, the leaching of chemicals from plastic products and the potential for plastics to transfer chemicals to wildlife and humans. However, perhaps the most important overriding concern, which is implicit throughout this volume, is that our current usage is not sustainable. Around 4 per cent of world oil production is used as a feedstock to make plastics and a similar amount is used as energy in the process. Yet over a third of current production is used to make items of packaging, which are then rapidly discarded. Given our declining reserves of fossil fuels, and finite capacity for disposal of waste to landfill, this linear use of hydrocarbons, via packaging and other short-lived applications of plastic, is simply not sustainable. There are solutions, including material reduction, design for end-of-life recyclability, increased recycling capacity, development of bio-based feedstocks, strategies to reduce littering, the application of green chemistry life-cycle analyses and revised risk assessment approaches. Such measures will be most effective through the combined actions of the public, industry, scientists and policymakers. There is some urgency, as the quantity of plastics produced in the first 10 years of the current century is likely to approach the quantity produced in the

  17. Surface soil moisture retrievals from remote sensing: Current status, products & future trends

    Science.gov (United States)

    Petropoulos, George P.; Ireland, Gareth; Barrett, Brian

    Advances in Earth Observation (EO) technology, particularly over the last two decades, have shown that soil moisture content (SMC) can be measured to some degree or other by all regions of the electromagnetic spectrum, and a variety of techniques have been proposed to facilitate this purpose. In this review we provide a synthesis of the efforts made during the last 20 years or so towards the estimation of surface SMC exploiting EO imagery, with a particular emphasis on retrievals from microwave sensors. Rather than replicating previous overview works, we provide a comprehensive and critical exploration of all the major approaches employed for retrieving SMC in a range of different global ecosystems. In this framework, we consider the newest techniques developed within optical and thermal infrared remote sensing, active and passive microwave domains, as well as assimilation or synergistic approaches. Future trends and prospects of EO for the accurate determination of SMC from space are subject to key challenges, some of which are identified and discussed within. It is evident from this review that there is potential for more accurate estimation of SMC exploiting EO technology, particularly so, by exploring the use of synergistic approaches between a variety of EO instruments. Given the importance of SMC in Earth's land surface interactions and to a large range of applications, one can appreciate that its accurate estimation is critical in addressing key scientific and practical challenges in today's world such as food security, sustainable planning and management of water resources. The launch of new, more sophisticated satellites strengthens the development of innovative research approaches and scientific inventions that will result in a range of pioneering and ground-breaking advancements in the retrievals of soil moisture from space.

  18. Current trends for improving the design of membrane devices for photoautotrophic biosynthesis is light dependent microorganisms

    Directory of Open Access Journals (Sweden)

    A. A. Shevtsov

    2016-01-01

    Full Text Available Modern trends in improving the design of membrane devices for photoautotrophic biosynthesis dependent lighting microorganisms aimed at a significant increase in the productivity of valuable products from biomass of microalgae and obtaining on the basis of their individual useful substances (drugs used in various industries and medicine. In film devices effectively the processes of heat - and mass-exchange with the gas comes into contact with the culture fluid flowing as a film on a transparent film-forming surface is STI in its light intensity and autotrophic biosynthesis occurs only in the presence of a mixture of air with carbon dioxide. Thus, completely eliminated the accumulation of metabolic products due to their continuous removal from film culture liquid with the process gas, which is not typical for devices of other types. Small size membrane bioreactors may increase the degree of saturation of the liquid carbon dioxide with the possibility of changing the concentration of gas in the culture fluid and to ensure the cultivation of microorganisms with a specified biomass yield. At present up to date-developed a significant number of ways to ensure contact of the gas with the liquid (bubbling, gas-lift, mechanical stirring, jet, membrane, etc. on the basis of which an industrial bioreactor, with various "stress" effect. It is believed that for the cultivation of the most optimal are bioreactors with mechanical stirring of the liquid, which allow the greatest productivity of biomass. However, the applied model of a mechanical mixing device to create a work whose cavity of the bioreactor chaotic, disorganized mixing, which contributes to the emergence, insufficient for the sustenance of the cell cultures and microorganisms. Analysis of the interactions of the gas with the liquid film devices showed the need to create a new generation of bioreactor with intensive mass transfer without the possibility of limiting the productivity of

  19. Cancer registration in Germany: current status, perspectives and trends in cancer incidence 1973-93.

    Science.gov (United States)

    Schüz, J; Schön, D; Batzler, W; Baumgardt-Elms, C; Eisinger, B; Lehnert, M; Stegmaier, C

    2000-01-01

    A federal law effective in 1995 makes it mandatory for all German States to build up population-based cancer registries. Although the law provides a model of cancer registration, each State may modify this by State-specific regulations, as long as they ensure data exchange between the registries and between registries and scientific institutions. The 'Network of German Population-Based Cancer Registries' constitutes the basis for cooperation among the German cancer registries. In order to improve the cooperation between physicians and epidemiologists, and to demonstrate the benefits of cancer registration, the network published a booklet containing facts on time-trends in cancer incidence during the last two decades. Information on cancer incidence and mortality was derived from the population-based cancer registries of Saarland, the former German Democratic Republic (until 1989), the City of Hamburg and the region of Münster. Altogether these registries cover a population of about 23 million. Sixteen types of cancer were selected for the analyses. Major increases in cancer incidence were observed for female lung cancer, testicular cancer, cancer of the oral cavity, malignant melanoma of the skin and non-Hodgkin's lymphoma. Incidence rates also increased for cancer of the female breast, prostate cancer and colorectal cancer. A decrease was observed for stomach and cervical cancer. In 1998, only a small fraction of all German adults were monitored by a population-based cancer registry, making it impossible to work out accurate incidence rates for the whole of Germany. Several new cancer registries have been built up recently. Data summaries of existing German population-based cancer registries assist in enhancing the completeness of new cancer registries.

  20. Grade 4 renal injury: current trend of management and future directions

    Institute of Scientific and Technical Information of China (English)

    Yiu Ming Ho; Michael Schuetz

    2011-01-01

    The management of blunt renal trauma has been evolving. The past management largely based on American Association for Surgery of Trauma (AAST) grading system, i.e. necessitated a computed tomography (CT)scan. Although the CT scan use is increasing and becomes the standardized mode of investigation, AAST grading no longer plays the sole role in the decision of surgical interventions. Two case reports of blunt renal trauma managed successfully by conservative methods are presented.Case one was an 18 year-old boy who had a fall when riding a motorbike at 20 km/h with a helmet and full protective equipments. He was landed by his left flank onto a rock.Contrast abdominal CT revealed a 4 em, grade Ⅲ splenic tear and a grade Ⅳ left kidney injury with large perirenal haematoma. His international severity score (ISS) was 34.He was managed conservatively with bed rest and frequent serum haemoglobin monitoring. Subsequent CT with delayed contrast revealed stable perirenal haematoma with urine extravasation which was consistent with a grade Ⅳ renal injury. Case two was a 40 year-old male who had a motor bike accident on a racetrack when he was driving at 80 to 100 km/h, wearing a helmet. He lost control and hit onto the sidewall of the racetrack. Contrast abdominal CT revealed a grade Ⅳ left renal injury with a large urine extravasation. His renal injury was managed conservatively with interval delayed phase CT of the abdomen. A repeat CT on abdomen was performed five months after the initial injury which revealed no residual urinoma.In this study, moreover, a review of the literature to the management of blunt renal trauma was conducted to demonstrate the trend of increasing conservative management of such traumas. Extra radiological parameters may guide future decision making. However, the applicability of data may be limited until randomized trials are available.

  1. Improving Control System Security through the Evaluation of Current Trends in Computer Security Research

    Energy Technology Data Exchange (ETDEWEB)

    Rolston

    2005-03-01

    At present, control system security efforts are primarily technical and reactive in nature. What has been overlooked is the need for proactive efforts, focused on the IT security research community from which new threats might emerge. Evaluating cutting edge IT security research and how it is evolving can provide defenders with valuable information regarding what new threats and tools they can anticipate in the future. Only known attack methodologies can be blocked, and there is a gap between what is known to the general security community and what is being done by cutting edge researchers --both those trying to protect systems and those trying to compromise them. The best security researchers communicate with others in their field; they know what cutting edge research is being done; what software can be penetrated via this research; and what new attack techniques and methodologies are being circulated in the black hat community. Standardization of control system applications, operating systems, and networking protocols is occurring at a rapid rate, following a path similar to the standardization of modern IT networks. Many attack methodologies used on IT systems can be ported over to the control system environment with little difficulty. It is extremely important to take advantage of the lag time between new research, its use on traditional IT networks, and the time it takes to port the research over for use on a control system network. Analyzing nascent trends in IT security and determining their applicability to control system networks provides significant information regarding defense mechanisms needed to secure critical infrastructure more effectively. This work provides the critical infrastructure community with a better understanding of how new attacks might be launched, what layers of defense will be needed to deter them, how the attacks could be detected, and how their impact could be limited.

  2. Public perception of hazardousness caused by current trends of municipal solid waste management.

    Science.gov (United States)

    Al-Khatib, Issam A; Kontogianni, Stamatia; Abu Nabaa, Hendya; Alshami, Ni'meh; Al-Sari', Majed I

    2015-02-01

    Municipal solid waste (MSW) piling up is becoming a serious problem in all developing countries (DC) as a result of inequitable waste collection and treatment. Citizens' collaboration is partly based on understanding their views and their active involvement in MSW planning; on the other hand the assessment of the perception of hazardousness related with MSW is considered rather important as well since the identification of the weak points of the applied MWM strategy is eased and the level of required training is determined. Researchers implemented a case study in the West Bank (WB) and Gaza Strip (GS) regions of Palestine, taking into consideration previous researches in other developing countries. They reached to safe and useful conclusions regarding the parameters which mean the greatest in the waste management field as far as DC are concerned. Lack of skilled manpower, irregular collection services, inadequate equipment used for waste collection, inadequate legal provisions, and resource constraints are additional factors that are confirmed to be challenging the waste management scenarios in all DCs today. The research takes those factors under consideration but focuses on the educational gap and the results revealed interesting trends a significant relationship between respondent's educational attainment and their awareness of hazardous waste (hazard perception); the results will indicate the measure taking required to avoid accidents occurred in those regions (burns from toxics, cuts from sharps, etc). National policy and legislation development based on the research outcomes will ensure equitable and accessible services are in place in order to move towards a healthier environment. Specialized health education and training programs on national scale are also needed to enhance awareness on hazardous waste.

  3. Learning analytics fundaments, applications, and trends : a view of the current state of the art to enhance e-learning

    CERN Document Server

    2017-01-01

    This book provides a conceptual and empirical perspective on learning analytics, its goal being to disseminate the core concepts, research, and outcomes of this emergent field. Divided into nine chapters, it offers reviews oriented on selected topics, recent advances, and innovative applications. It presents the broad learning analytics landscape and in-depth studies on higher education, adaptive assessment, teaching and learning. In addition, it discusses valuable approaches to coping with personalization and huge data, as well as conceptual topics and specialized applications that have shaped the current state of the art. By identifying fundamentals, highlighting applications, and pointing out current trends, the book offers an essential overview of learning analytics to enhance learning achievement in diverse educational settings. As such, it represents a valuable resource for researchers, practitioners, and students interested in updating their knowledge and finding inspirations for their future work.

  4. [Genetically modified food (food derived from biotechnology): current and future trends in public acceptance and safety assessment].

    Science.gov (United States)

    Nishiura, Hiroshi; Imai, Hirohisa; Nakao, Hiroyuki; Tsukino, Hiromasa; Kuroda, Yoshiki; Katoh, Takahiko

    2002-11-01

    Current and future trends regarding genetically modified (GM) crops and food stuffs were reviewed, with a particular focus on public acceptance and safety assessment. While GM foods, foods derived from biotechnology, are popular with growers and producers, they are still a matter of some concern among consumers. In fact, our recent surveys showed that Japanese consumers had become uneasy about the potential health risks of genetically modified foods. Many Japanese consumers have only vague ideas about the actual health risks, and they appear to be making decisions simply by rejecting GM food because of non-informed doubts. Although the debate about GM foods has increased in the mass media and scientific journals, few articles concerning direct studies on the potential toxicity or adverse health effects of GM foods have appeared. The roles of relevant international regulatory bodies in ensuring that GM crops and food are safe are therefore have summarized. Finally, the current debate on use of GM crops in agriculture and future trends for development of GM foods with enriched nutrients, better functionality, and medicinal ingredients, which will be of direct benefit to the consumer, are covered.

  5. Segmentation and Image Analysis of Abnormal Lungs at CT: Current Approaches, Challenges, and Future Trends

    Science.gov (United States)

    Mansoor, Awais; Foster, Brent; Xu, Ziyue; Papadakis, Georgios Z.; Folio, Les R.; Udupa, Jayaram K.; Mollura, Daniel J.

    2015-01-01

    The computer-based process of identifying the boundaries of lung from surrounding thoracic tissue on computed tomographic (CT) images, which is called segmentation, is a vital first step in radiologic pulmonary image analysis. Many algorithms and software platforms provide image segmentation routines for quantification of lung abnormalities; however, nearly all of the current image segmentation approaches apply well only if the lungs exhibit minimal or no pathologic conditions. When moderate to high amounts of disease or abnormalities with a challenging shape or appearance exist in the lungs, computer-aided detection systems may be highly likely to fail to depict those abnormal regions because of inaccurate segmentation methods. In particular, abnormalities such as pleural effusions, consolidations, and masses often cause inaccurate lung segmentation, which greatly limits the use of image processing methods in clinical and research contexts. In this review, a critical summary of the current methods for lung segmentation on CT images is provided, with special emphasis on the accuracy and performance of the methods in cases with abnormalities and cases with exemplary pathologic findings. The currently available segmentation methods can be divided into five major classes: (a) thresholding-based, (b) region-based, (c) shape-based, (d) neighboring anatomy–guided, and (e) machine learning–based methods. The feasibility of each class and its shortcomings are explained and illustrated with the most common lung abnormalities observed on CT images. In an overview, practical applications and evolving technologies combining the presented approaches for the practicing radiologist are detailed. ©RSNA, 2015 PMID:26172351

  6. Evolutionary multi-objective optimization: some current research trends and topics that remain to be explored

    Institute of Scientific and Technical Information of China (English)

    Carlos A. COELLO COELLO

    2009-01-01

    This paper provides a short review of some of the main topics in which the current research in evolutionary multi-objective optimization is being focused. The topics discussed include new algorithms, efficiency, relaxed forms of dominance, scalability, and alternative metaheuristics. This discussion motivates some further topics which,from the author's perspective, constitute good potential areas for future research, namely, constraint-handling techniques,incorporation of user's preferences and parameter control,This information is expected to be useful for those interested in pursuing research in this area.

  7. Current Trends in Psychological and Educational Approaches for Training and Teaching Students with Autism in California

    Directory of Open Access Journals (Sweden)

    Trisha SUGITA

    2016-12-01

    Full Text Available Within the United States, Autism Spectrum Disorder (ASD has seen a dramatic increase over the past twenty years. As the prevalence rate of ASD increases, an increased need for expertise in the field of education has become apparent. Psychological and educational practices for training and teaching students with ASD continue to evolve in California however, a significant gap between theory and practice remains. This article provides a historical perspective of ASD and its prevalence rates. In addition, this article examines the current shifts in teacher training and provides an overview of evidence-based strategies to support students with ASD.

  8. Public perception of hazardousness caused by current trends of municipal solid waste management

    Energy Technology Data Exchange (ETDEWEB)

    Al-Khatib, Issam A., E-mail: ikhatib@birzeit.edu [Institute of Environmental and Water Studies, Birzeit University, Birzeit, Palestine (Country Unknown); Kontogianni, Stamatia [Laboratory of Heat Transfer and Environmental Engineering, Dpt. of Mechanical Engineering, Aristotle University of Thessaloniki, Box 483, 54006 Thessaloniki (Greece); Abu Nabaa, Hendya; Alshami, Ni’meh [Faculty of Graduate Studies, Birzeit University, Birzeit, Palestine (Country Unknown); Al-Sari’, Majed I. [The Joint Services Council for Solid Waste Management for Hebron and Bethlehem Governorates JSC-H& B, West Bank (Palestinian Territory, Occupied)

    2015-02-15

    Highlights: • Contribution to the scientific literature by examining the relationship between concern for the environment and waste disposal in the frame of household waste treatment mechanism specifically in developing countries. • The awareness of the citizens satisfaction level and the local existing capacities in developing countries significantly contribute to decision making on MSW management sustainability in Palestine and other developing countries when applied. • Identification of the differences and similarities among DC resulting to failures or success in WM field. - Abstract: Municipal solid waste (MSW) piling up is becoming a serious problem in all developing countries (DC) as a result of inequitable waste collection and treatment. Citizens’ collaboration is partly based on understanding their views and their active involvement in MSW planning; on the other hand the assessment of the perception of hazardousness related with MSW is considered rather important as well since the identification of the weak points of the applied MWM strategy is eased and the level of required training is determined. Researchers implemented a case study in the West Bank (WB) and Gaza Strip (GS) regions of Palestine, taking into consideration previous researches in other developing countries. They reached to safe and useful conclusions regarding the parameters which mean the greatest in the waste management field as far as DC are concerned. Lack of skilled manpower, irregular collection services, inadequate equipment used for waste collection, inadequate legal provisions, and resource constraints are additional factors that are confirmed to be challenging the waste management scenarios in all DCs today. The research takes those factors under consideration but focuses on the educational gap and the results revealed interesting trends a significant relationship between respondent’s educational attainment and their awareness of hazardous waste (hazard perception); the

  9. Support vector machine based estimation of remaining useful life: current research status and future trends

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Hong Zhong; Wang, Hai Kun; Li, Yan Feng; Zhang, Longlong; Liu, Zhiliang [University of Electronic Science and Technology of China, Chengdu (China)

    2015-01-15

    Estimation of remaining useful life (RUL) is helpful to manage life cycles of machines and to reduce maintenance cost. Support vector machine (SVM) is a promising algorithm for estimation of RUL because it can easily process small training sets and multi-dimensional data. Many SVM based methods have been proposed to predict RUL of some key components. We did a literature review related to SVM based RUL estimation within a decade. The references reviewed are classified into two categories: improved SVM algorithms and their applications to RUL estimation. The latter category can be further divided into two types: one, to predict the condition state in the future and then build a relationship between state and RUL; two, to establish a direct relationship between current state and RUL. However, SVM is seldom used to track the degradation process and build an accurate relationship between the current health condition state and RUL. Based on the above review and summary, this paper points out that the ability to continually improve SVM, and obtain a novel idea for RUL prediction using SVM will be future works.

  10. CURRENT AFFORESTATION PRACTICE AND EXPECTED TRENDS ON FAMILY FARMS IN WEST HUNGARY

    Directory of Open Access Journals (Sweden)

    Zoltan ANDRASEVITS

    2005-04-01

    Full Text Available The primary aim of the National Forest Strategy and National Development Plan in Hungary is to increase the ratio of forest cover from the current level of 19,7% to 26-28%. This means planting 700,000 ha of new forest plantation in Hungary between now and 2035. Around 90% of the afforestation1 will occur on private land. So the simultaneous improvement of farming and forestry is critical. Our survey sought to capture the current situation in western Hungary. Our aim was to research the possibilities for complimentary development of agriculture and forestry on family owned farms. Relatedly, we wanted to know about the motivations of farmers regarding afforestation. We established that forestry does not have a favorable effect on the labour effi ciency of agriculture and does not reduce the seasonality of agriculture. Most of the farmers consider afforestation could be a good investment or a potential source of better profi t. However, the level of support available is what mainly motivates willingness to plant tree crops. They believe that the government should compensate short-term profi t loss (due to land set aside for tree crops with longer-term subsidies (according to established EU support practices

  11. Coverage of protein domain families with structural protein-protein interactions: current progress and future trends.

    Science.gov (United States)

    Goncearenco, Alexander; Shoemaker, Benjamin A; Zhang, Dachuan; Sarychev, Alexey; Panchenko, Anna R

    2014-01-01

    Protein interactions have evolved into highly precise and regulated networks adding an immense layer of complexity to cellular systems. The most accurate atomistic description of protein binding sites can be obtained directly from structures of protein complexes. The availability of structurally characterized protein interfaces significantly improves our understanding of interactomes, and the progress in structural characterization of protein-protein interactions (PPIs) can be measured by calculating the structural coverage of protein domain families. We analyze the coverage of protein domain families (defined according to CDD and Pfam databases) by structures, structural protein-protein complexes and unique protein binding sites. Structural PPI coverage of currently available protein families is about 30% without any signs of saturation in coverage growth dynamics. Given the current growth rates of domain databases and structural PPI deposition, complete domain coverage with PPIs is not expected in the near future. As a result of this study we identify families without any protein-protein interaction evidence (listed on a supporting website http://www.ncbi.nlm.nih.gov/Structure/ibis/coverage/) and propose them as potential targets for structural studies with a focus on protein interactions. Published by Elsevier Ltd.

  12. Current trends, figures and challenges in out of home child care: An internationalcomparative analysis

    Directory of Open Access Journals (Sweden)

    Jorge F. del Valle

    2014-03-01

    Full Text Available This article closes the special issue of this journal about an international review of out-of-home child care, principally family foster care and residential care, tough several aspects related to adoption were included as well. Although a comparison on some data about residential and foster care, or kinship and non-kinship care, is carried out, the article tries above all to make a reflection on the implications of several themes that have emerged as more interesting or important. Matters such as the use of residential care and its role in the current child care system, the overrepresentation of ethnic minorities in foster care in several countries, the situation of unaccompanied young people asylum seeking, the use of adoption as a permanent solution, the challenges of the transition to the adulthood from care, the relevance of the professionalization and models based on social pedagogy, the evaluation and planning based on data, and the current financial crisis and its impact on child care systems are some of the remarkable topics that will be reviewed.

  13. Management of benign prostatic hypertrophy-related urinary retention: current trends and perspectives.

    Science.gov (United States)

    Stamatiou, Konstantinos

    2009-01-01

    The failure of prostate-directed treatment modalities to help all men or all symptoms has questioned the longstanding assumption that the prostate is at the root of all male urinary symptoms, and a correlation between urinary bladder function and prostate pathology has been recognized. Now, it is widely recognized that bladder dysfunction plays a role in some, if not most, of the benign prostatic hyperplasia-related symptoms and signs, and recent studies have suggested that pharmacotherapies that target the bladder, such as antimuscarinics, may improve storage urinary symptoms. Indeed, the current mainstays of overactive bladder syndrome pharmacotherapy are antimuscarinic agents with mixed actions, including musculotropic (calcium antagonistic) activity. Moreover, the combination therapy with alpha blocker and antimuscarinic agents is now suggested when bladder outlet obstruction related to benign prostatic hyperplasia coexists with overactive bladder symptoms. Combinational treatment, targeting to both decrease resistance to urine outflow through the prostatic urethra and increase bladder smooth muscle, may improve the bladder outlet surgery success rate, and perhaps it might reinforce the need to offer an additional trial without catheter in patients with benign prostatic hyperplasia who are likely to suffer from detrusor hypocontractivity. Currently, no clinical trial supporting the use of parasympathomimetic drugs in those with poor voiding and longstanding symptomatic benign prostatic hyperplasia exists in the literature; however, experimental studies present promising results.

  14. Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.

    Science.gov (United States)

    Zhan, Peng; Pannecouque, Christophe; De Clercq, Erik; Liu, Xinyong

    2016-04-14

    The early effectiveness of combinatorial antiretroviral therapy (cART) in the treatment of HIV infection has been compromised to some extent by rapid development of multidrug-resistant HIV strains, poor bioavailability, and cumulative toxicities, and so there is a need for alternative strategies of antiretroviral drug discovery and additional therapeutic agents with novel action modes or targets. From this perspective, we first review current strategies of antiretroviral drug discovery and optimization, with the aid of selected examples from the recent literature. We highlight the development of phosphate ester-based prodrugs as a means to improve the aqueous solubility of HIV inhibitors, and the introduction of the substrate envelope hypothesis as a new approach for overcoming HIV drug resistance. Finally, we discuss future directions for research, including opportunities for exploitation of novel antiretroviral targets, and the strategy of activation of latent HIV reservoirs as a means to eradicate the virus.

  15. Current and future trends in biomarker discovery and development of companion diagnostics for arthritis.

    Science.gov (United States)

    Gibson, David S; Bustard, Michael J; McGeough, Cathy M; Murray, Helena A; Crockard, Martin A; McDowell, Andrew; Blayney, Jayne K; Gardiner, Philip V; Bjourson, Anthony J

    2015-02-01

    Musculoskeletal diseases such as rheumatoid arthritis are complex multifactorial disorders that are chronic in nature and debilitating for patients. A number of drug families are available to clinicians to manage these disorders but few tests exist to target these to the most responsive patients. As a consequence, drug failure and switching to drugs with alternate modes of action is common. In parallel, a limited number of laboratory tests are available which measure biological indicators or 'biomarkers' of disease activity, autoimmune status, or joint damage. There is a growing awareness that assimilating the fields of drug selection and diagnostic tests into 'companion diagnostics' could greatly advance disease management and improve outcomes for patients. This review aims to highlight: the current applications of biomarkers in rheumatology with particular focus on companion diagnostics; developments in the fields of proteomics, genomics, microbiomics, imaging and bioinformatics and how integration of these technologies into clinical practice could support therapeutic decisions.

  16. Effects of micro- and nanoplastics on aquatic ecosystems: Current research trends and perspectives.

    Science.gov (United States)

    Chae, Yooeun; An, Youn-Joo

    2017-02-17

    Contamination by bulk plastics and plastic debris is currently the one of the most serious environmental problems in aquatic ecosystems. In particular, small-scale plastic debris such as microplastics and nanoplastics has become leading contributors to the pollution of marine and freshwater ecosystems. Studies are investigating the impacts of micro-and nanoplastics on aquatic organisms and ecosystems worldwide. This review covers 83 studies that investigated the distribution of microplastics and the ecotoxicity of micro- and nanoplastics in marine and freshwater ecosystems. The studies indicated that micro-sized plastics and plastic debris were distributed at various concentrations in aquatic ecosystems around the world. They had various effects on the growth, development, behavior, reproduction, and mortality of aquatic animals. We discuss these studies in detail and suggest directions for future research.

  17. Biodiversity in a changing climate: a synthesis of current and projected trends in the US

    Science.gov (United States)

    Staudinger, Michelle D.; Carter, Shawn L.; Cross, Molly S.; Dubois, Natalie S.; Duffy, J. Emmett; Enquist, Carolyn; Griffis, Roger; Hellmann, Jessica J.; Lawler, Joshua J.; O’Leary, John; Morrison, Scott A.; Sneddon, Lesley; Stein, Bruce A.; Thompson, Laura M.; Turner, Woody

    2013-01-01

    This paper provides a synthesis of the recent literature describing how global biodiversity is being affected by climate change and is projected to respond in the future. Current studies reinforce earlier findings of major climate-change-related impacts on biological systems and document new, more subtle after-effects. For example, many species are shifting their distributions and phenologies at faster rates than were recorded just a few years ago; however, responses are not uniform across species. Shifts have been idiosyncratic and in some cases counterintuitive, promoting new community compositions and altering biotic interactions. Although genetic diversity enhances species' potential to respond to variable conditions, climate change may outpace intrinsic adaptive capacities and increase the relative vulnerabilities of many organisms. Developing effective adaptation strategies for biodiversity conservation will not only require flexible decision-making and management approaches that account for uncertainties in climate projections and ecological responses but will also necessitate coordinated monitoring efforts.

  18. Current and predicted trends in the production, consumption and trade of live animals and their products.

    Science.gov (United States)

    Narrod, C; Tiongco, M; Scott, R

    2011-04-01

    Changes in livestock production, driven by both demand- and supply-side factors, have been significant worldwide. Though historically the developed world was a large supplier of meat and livestock for the developing world, the developing world has rapidly increased production and is meeting more of its growing domestic demand. Many regions of the developing world, however, do not produce enough currently to meet their domestic demand and continue to import more than they produce. There are exceptions, such as Brazil, Thailand, the People's Republic of China and India, where growth in livestock production has been rapid. It is anticipated that in the future many of the developing countries will increase domestic production to meet growing domestic demand. By 2030, beef will probably still be the most significant meat import of developing countries and milk will have more than doubled as a net export of the developed world.

  19. Resident Involvement in Professional Otolaryngology Organizations: Current Trends in the United States.

    Science.gov (United States)

    Wong, Kevin; Jang, Minyoung; Gilad, Amir; Levi, Jessica R

    2017-08-01

    Involvement by residents in professional medical organizations can enrich their training, but little data exist regarding the number and types of involvement opportunities available to otolaryngology residents. We sought to fill this gap in knowledge by quantifying the extent to which major otolaryngology-related organizations in the United States provide involvement opportunities to otolaryngology residents. Our analysis included 23 organizations and subspecialty societies. Results showed that many opportunities exist for residents to attend conferences and present research; however, fewer involvement and funding opportunities existed in any other leadership, health policy, or service-learning experiences. These findings were consistent across general and subspecialty societies. Given the many purported benefits of resident involvement in otolaryngology outside of the standard training environment, future efforts may be warranted to increase the number and type of involvement opportunities currently available in professional societies.

  20. Multimodal neuroimaging as a window into the pathological physiology of schizophrenia: Current trends and issues.

    Science.gov (United States)

    Isobe, Masanori; Miyata, Jun; Hazama, Masaaki; Fukuyama, Hidenao; Murai, Toshiya; Takahashi, Hidehiko

    2016-01-01

    Visualizing the detailed brain anatomy of individuals with schizophrenia has been made possible by recent advances in magnetic resonance imaging (MRI). Although structural MRI cannot be currently used to diagnose schizophrenia, multimodal MRI can reveal insightful information on key clinical aspects of the pathological physiology of schizophrenia. However, in this regard, the number of multimodal MRI studies is still limited and definitely required. In this review, we discuss how classical and popular theories on the pathological physiology of schizophrenia can be re-examined using neuroimaging studies, and also discuss how multimodal MRI studies may provide additional findings. The pathological hypotheses examined include the "progressive brain disease hypothesis" and "disconnection hypothesis". This article is discussed mainly based on recent findings published by our research group.

  1. Trends in Dental Practice Sales and Associateships in the Current Economy

    Directory of Open Access Journals (Sweden)

    C. Steven Wolff

    2011-10-01

    Full Text Available Recent experiences would suggest that there is a significant discrepancy in the number of doctors retiring and transitioning their practices and the number of younger practitioners wishing to assume ownership and build a career. Peaks and valleys in dental school enrollment over the last forty years should have produced an abundance of retirement aged doctors wishing to place their practices on the market to a smaller pool of buyers. Such is currently not the case. Doctors in their sixties have experienced recent stock market downturns in 2000 and 2008, the “9-11” tragedy and a drop in both the value and liquidity of the housing market. The ready access to refinance or second mortgage funds may even find some doctors upside down on personal, vacation and investment real estate. All of this combined has had considerable negative impact on their net worth. Health care costs continue to increase and most dentists are personally responsible for their premiums. Combine all of this with the current low level of secure returns on invested capital along with a significant increase in life expectancy over the last two generations and many decide they are simply unable to retire as planned. The fear of running out of money is stronger than their will to pursue retirement. This article examines in some detail the reasons for this imbalance and the effects they are having on practice transitions, practice values and the market for associate employment. We will also explore what the future may hold for both retiring and new career doctors.

  2. Estimating the success of enzyme bioprospecting through metagenomics: current status and future trends.

    Science.gov (United States)

    Ferrer, Manuel; Martínez-Martínez, Mónica; Bargiela, Rafael; Streit, Wolfgang R; Golyshina, Olga V; Golyshin, Peter N

    2016-01-01

    Recent reports have suggested that the establishment of industrially relevant enzyme collections from environmental genomes has become a routine procedure. Across the studies assessed, a mean number of approximately 44 active clones were obtained in an average size of approximately 53,000 clones tested using naïve screening protocols. This number could be significantly increased in shorter times when novel metagenome enzyme sequences obtained by direct sequencing are selected and subjected to high-throughput expression for subsequent production and characterization. The pre-screening of clone libraries by naïve screens followed by the pyrosequencing of the inserts allowed for a 106-fold increase in the success rate of identifying genes encoding enzymes of interest. However, a much longer time, usually on the order of years, is needed from the time of enzyme identification to the establishment of an industrial process. If the hit frequency for the identification of enzymes performing at high turnover rates under real application conditions could be increased while still covering a high natural diversity, the very expensive and time-consuming enzyme optimization phase would likely be significantly shortened. At this point, it is important to review the current knowledge about the success of fine-tuned naïve- and sequence-based screening protocols for enzyme selection and to describe the environments worldwide that have already been subjected to enzyme screen programmes through metagenomic tools. Here, we provide such estimations and suggest the current challenges and future actions needed before environmental enzymes can be successfully introduced into the market.

  3. Current usage and future trends in gross digital photography in Canada.

    Science.gov (United States)

    Horn, Christopher L; DeKoning, Lawrence; Klonowski, Paul; Naugler, Christopher

    2014-01-14

    The purpose of this study was to assess the current usage, utilization and future direction of digital photography of gross surgical specimens in pathology laboratories across Canada. An online survey consisting of 23 multiple choice and free-text questions regarding gross digital photography was sent out to via email to laboratory staff across Canada involved in gross dissection of surgical specimens. Sixty surveys were returned with representation from most of the provinces. Results showed that gross digital photography is utilized at most institutions (90.0%) and the primary users of the technology are Pathologists (88.0%), Pathologists' Assistants (54.0%) and Pathology residents (50.0%). Most respondents felt that there is a definite need for routine digital imaging of gross surgical specimens in their practice (80.0%). The top two applications for gross digital photography are for documentation of interesting/ complex cases (98.0%) and for teaching purposes (84.0%). The main limitations identified by the survey group are storage space (42.5%) and security issues (40.0%). Respondents indicated that future applications of gross digital photography mostly include teaching (96.6%), presentation at tumour boards/ clinical rounds (89.8%), medico-legal documentation (72.9%) and usage for consultation purposes (69.5%). The results of this survey indicate that pathology staff across Canada currently utilizes gross digital images for regular documentation and educational reasons. They also show that the technology will be needed for future applications in teaching, consultation and medico-legal purposes.

  4. Effects of plasmonic coupling and electrical current on persistent photoconductivity of single-layer graphene on pristine and silver-nanoparticle-coated SiO2/Si.

    Science.gov (United States)

    Liu, Chih-Yi; Liang, Kengchih; Chang, Chun-Cheng; Tzeng, Yonhua

    2012-09-24

    Effects and mechanisms of conductivity variation of chemically vapor deposited single-layer graphene covering silver nanoparticles on SiO(2)/Si are reported based on blue-light (405 nm) induced plasmonic coupling and electrical current induced annealing and desorption of surface adsorbates. With 1V applied voltage, photoconductivity is positive except a brief negative period when the graphene is first illuminated by light. At 10 mV applied voltage, negative photoconductivity persists for hours. In comparison, negative photoconductivity of graphene on pristine SiO(2)/Si persists for tens of hours. When the applied voltage is increased to 1V, it takes tens of hours of light illumination to change to positive photoconductivity.

  5. Current trends in local antibacterial therapy of periprosthetic infection and osteomyelitis

    Directory of Open Access Journals (Sweden)

    S. A. Bozhkova

    2015-01-01

    Full Text Available The rational use of antibiotics in the treatment of orthopedic infection still presents a significant problem. Local antibiotic delivery systems enable to achieve effective concentrations of drugs in the focus of bone infection without the development of toxicity. It is the important accompaniment to systemic antibiotics in the treatment of periprosthetic infection and osteomyelitis. The data collected through the PubMed and eLIBRARY databases (http://www.ncbi.nlm. nih.gov/pubmed, 1995-2015; http://elibrary.ru, 2005-2015 years present the information about bone substitutes used for local antibiotic therapy in scientific investigations and in clinical practice. The information is submitted in accordance with the groups of materials: cements based on polymethylmethacrylate, bone grafts, demineralized bone matrix, bioceramics, natural and synthetic polymers, combined antibiotic delivery systems. The majority of these materials have only been studied experimentally and only a limited range of them is registered for use in clinical practice. Informing orthopedic surgeons about current methods of local antibiotic use is the key to the development of a modern integrated approach to the therapy of infectious complications after orthopedic surgery.

  6. Type 2 diabetes mellitus in Malaysia: current trends and risk factors.

    Science.gov (United States)

    Tee, E-S; Yap, R W K

    2017-07-01

    This review discussed the prevalence of diabetes mellitus (DM) in Malaysia and the associated major risk factors, namely overweight/obesity, dietary practices and physical activity in both adults and school children. Detailed analyses of such information will provide crucial information for the formulation and implementation of programmes for the control and prevention of T2DM in the country. National studies from 1996-2015, and other recent nation-wide studies were referred to. The current prevalence of DM in 2015 is 17.5%, over double since 1996. Females, older age group, Indians, and urban residents had the highest risk of DM. The combined prevalence of overweight/obesity in 2015 is 47.7% for adults. Adults did not achieve the recommended intakes for majority of the foods groups in the Malaysian Food Pyramid especially fruits and vegetables. Adults also had moderate physical activity level. Three nation-wide studies showed a prevalence ranging from 27 to 31% for combined overweight/obesity in school children. The prevalence was higher among boys, primary school age, Indian ethnicity, and even rural children are not spared. Physical activity level was also low among school children. There must be serious systematic implementation of action plans to combat the high prevalence of diabetes and associated risk factors.

  7. Medicinal use of cannabis in the United States: historical perspectives, current trends, and future directions.

    Science.gov (United States)

    Aggarwal, Sunil K; Carter, Gregory T; Sullivan, Mark D; ZumBrunnen, Craig; Morrill, Richard; Mayer, Jonathan D

    2009-01-01

    Cannabis (marijuana) has been used for medicinal purposes for millennia, said to be first noted by the Chinese in c. 2737 BCE. Medicinal cannabis arrived in the United States much later, burdened with a remarkably checkered, yet colorful, history. Despite early robust use, after the advent of opioids and aspirin, medicinal cannabis use faded. Cannabis was criminalized in the United States in 1937, against the advice of the American Medical Association submitted on record to Congress. The past few decades have seen renewed interest in medicinal cannabis, with the National Institutes of Health, the Institute of Medicine, and the American College of Physicians, all issuing statements of support for further research and development. The recently discovered endocannabinoid system has greatly increased our understanding of the actions of exogenous cannabis. Endocannabinoids appear to control pain, muscle tone, mood state, appetite, and inflammation, among other effects. Cannabis contains more than 100 different cannabinoids and has the capacity for analgesia through neuromodulation in ascending and descending pain pathways, neuroprotection, and anti-inflammatory mechanisms. This article reviews the current and emerging research on the physiological mechanisms of cannabinoids and their applications in managing chronic pain, muscle spasticity, cachexia, and other debilitating problems.

  8. Surgical margins in breast-conserving therapy: current trends and future prospects.

    Science.gov (United States)

    Sanguinetti, Alessandro; Lucchini, Roberta; Santoprete, Stefano; Bistoni, Giovanni; Avenia, Stefano; Triola, Roberto; Avenia, Nicola

    2013-01-01

    Inadequate surgical margins represent a high risk for adverse clinical outcome in breast-conserving therapy (BCT) for early-stage breast cancer. The majority of studies report positive resection margins in 20% to 40% of the patients who underwent BCT. This may result in an increased local recurrence (LR) rate or additional surgery and, consequently, adverse effects on cosmesis, psychological distress, and health costs. In the literature, various risk factors are reported to be associated with positive margin status after lumpectomy, which may allow the surgeon to distinguish those patients with a higher “a priori” risk for re-excision. However, most risk factors are related to tumor biology and patient characteristics, which cannot be modified as such. Therefore, efforts to reduce the number of positive margins should focus on optimizing the surgical procedure itself, because the surgeon lacks real time intraoperative information on the presence of positive resection margins during breast-conserving surgery. This review presents the status of pre- and intraoperative modalities currently used in BCT. Furthermore, innovative intraoperative approaches, such as positron emission tomography, radio-guided occult lesion localization, and near-infrared fluorescence optical imaging, are addressed, which have to prove their potential value in improving surgical outcome and reducing the need for re-excision in BCT.

  9. Current Trends in the Studies of Allelochemicals for Their Application in Practice

    Directory of Open Access Journals (Sweden)

    Arsen V.Viter

    2015-06-01

    Full Text Available The allelochemicals have been largely used in agriculture, forestry, landscape design and ornamental plant growing for many decades. However, there is a lack of the comprehensive studies, where existing publications are analyzed and synthesized with regards to the theoretic aspects for such usage. The objective of this paper was to systemize the advances in the research on allelochemicals’ application in practice. Numerous novel methodological propositions have risen recently. We classified them into the physical, chemical, biological, biotechnological and cropgrowing approaches. The allelochemicals consist of the wide diversity of the substances according to their chemical nature. Among these substances we outlined, firstly, the unidentified plant exudates and the products of green manuring, secondly, the chemically characterized or purified substances, which include alcohols, organic acids, aliphatic compounds, aromatic, alicyclic and nitrogen-contain organic compounds. Several groups of the biotic sources of allelochemicals were described: dicotyledonous and monocotyledonous plants, particularly under their colonization by non-pathogenic strains of Fusarium oxysporum, marine flora and fungi, which exhibit the herbicidal activity. Different targets of the allelochemical application were listed in the paper and they were categorized into several groups: higher flora, animals, unicellular and multi-cellular fungi. We concluded that there is lack of the modern multifaceted knowledge bases for the information about the allelochemical application. Those knowledge bases must be useful in order to choose the appropriate biological method for solving each particular problem of plant cultivation. To that end we systemized the results of current investigation about the usage of allelochemicals in practice.

  10. Current trends and controversies in the management of patients with splenic flexure tumours

    Directory of Open Access Journals (Sweden)

    Chan DS

    2013-03-01

    Full Text Available Aim: There exists a variation in practice in the management of tumours around the splenic flexure. We aim to determine the current opinion regarding the management of these tumours. Methods: An anonymised 10-part online questionnaire was sent to all members of the Association of Coloproctology of Great Britain and Ireland (ACPGBI. Results: The response rate was 24% (111/464 with approximately half of respondents performing laparoscopic surgery. Electively, an extended right hemicolectomy is the preferred option by 63% of respondents followed by left hemicolectomy (23% and segmental resection (14%. The upper sigmoid and rectosigmoid is the preferred site of anastomosis by 90% and 10% of respondents respectively. There were no significant differences in the type of operations performed by surgeons who practice laparoscopic or open surgery (p=0.10. A hand-sewn end-to-end anastomosis is most commonly performed (51% followed by a stapled side-to-side (36% and a stapled end-to-end (13% technique. Extended right hemicolectomy is also the preferred option in obstructing tumours. Of surgeons who perform segmental resections, 27% perform an on-table lavage and 9% perform a defunctioning stoma. Internal herniation following laparoscopic resection was only reported by a handful of surgeons. Conclusion: Opinion and practice in the management of patients with tumours around the splenic flexure are divided. Further trials are indicated to determine the best practice.

  11. An overview of currently available methods and future trends for physical activity

    Directory of Open Access Journals (Sweden)

    Alexander Kiško

    2013-12-01

    Full Text Available Background: Methodological limitations make comparison of various instruments difficult, although the number of publications on physical activity assessment has extensively increased. Therefore, systematization of techniques and definitions is essential for the improvement of knowledge in the area. Objective: This paper systematically describes and compares up-to-date methods that assess habitual physical activity and discusses main issues regarding the use and interpretation of data collected with these techniques. Methods: A general outline of the measures and techniques described above is presented in review form, along with their respective definition, usual applications, positive aspects and shortcomings. Results and conclusions: The various factors to be considered in the selection of physical activity assessment methods include goals, sample size, budget, cultural and social/environmental factors, physical burden for the subject, and statistical factors, such as accuracy and precision. It is concluded that no single current technique is able to quantify all aspects of physical activity under free-living conditions, requiring the use of complementary methods. In not too distant future, devices will take advantage of consumer technologies, such as mobile phones, GPS devices. It is important to perform other activities, such as detecting and responding to physical activity in a real time, creating new opportunities in measurement, remote compliance monitoring, data-driven discovery and intervention.

  12. Iran`s petroleum policy: Current trends and the future outlook

    Energy Technology Data Exchange (ETDEWEB)

    Pezeshki, S.; Fesharaki, F.

    1994-12-01

    The Iranian economy and political situation have undergone radical changes since the 1979 Islamic revolution. The excesses of the early years of the revolution have gradually given way to moderation and a more pragmatic economic policy--based on the principles of the free market. The petroleum policy, as a subset of the economic policies, has been somewhat affected by the political and economic developments in Iran. The petroleum policy has changed from a position of no foreign participation to a position that includes a desire for foreign participation, the text of a model contract, and an attempt to introduce new technologies in the upstream sector. This report provides an overview of the key issues facing the Iranian oil industry and the economic context in which the oil industry is operating in Iran. It describes the evolution of policies meant to move the oil industry toward the free market; it discusses Iran`s oil trading partners, the outlook for refining and project investments, and current and likely future developments in the natural gas and petrochemical sectors. In short, the report provides an up-to-date assessment of the Iranian petroleum sector and its likely evolution in the future.

  13. Climate Change Vulnerability and Resilience: Current Status and Trends for Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Ibarraran , Maria E.; Malone, Elizabeth L.; Brenkert, Antoinette L.

    2008-12-30

    Climate change alters different localities on the planet in different ways. The impact on each region depends mainly on the degree of vulnerability that natural ecosystems and human-made infrastructure have to changes in climate and extreme meteorological events, as well as on the coping and adaptation capacity towards new environmental conditions. This study assesses the current resilience of Mexico and Mexican states to such changes, as well as how this resilience will look in the future. In recent studies (Moss et al. 2000, Brenkert and Malone 2005, Malone and Brenket 2008, Ibarrarán et al. 2007), the Vulnerability-Resilience Indicators Model (VRIM) is used to integrate a set of proxy variables that determine the resilience of a region to climate change. Resilience, or the ability of a region to respond to climate variations and natural events that result from climate change, is given by its adaptation and coping capacity and its sensitivity. On the one hand, the sensitivity of a region to climate change is assessed, emphasizing its infrastructure, food security, water resources, and the health of the population and regional ecosystems. On the other hand, coping and adaptation capacity is based on the availability of human resources, economic capacity and environmental capacity.

  14. Current Trends in Neuromuscular Blockade, Management, and Monitoring amongst Singaporean Anaesthetists

    Directory of Open Access Journals (Sweden)

    Wendy H. Teoh

    2016-01-01

    Full Text Available Introduction. This survey aimed to investigate the attitudes/practice pertaining the use, management, and monitoring of neuromuscular blockade amongst Singaporean anaesthetists. Methods. All specialist accredited anaesthetists registered with the Singapore Medical Council were invited to complete an anonymous online survey. Results. The response rate was 39.5%. Neuromuscular monitoring (NM was used routinely by only 13.1% despite the widespread availability of monitors. 82% stated residual NMB (RNMB was a significant risk factor for patient outcome, but only 24% believed NMB monitoring should be compulsory in all paralyzed patients. 63.6% of anaesthetists estimated the risk of RNMB in their own institutions to be 50% said such benefits may be able to offset the associated costs. Conclusions. There is a significant need for reeducation about RNMB, studies on local RNMB incidences, and strengthening of current monitoring practices and guidelines. Strategies are discussed. As NM monitors appear widely available and reversal of NMB standard practice, it is hopeful that Singaporean anaesthetists will change and strive for evidence-based best clinical practice to enhance patient safety.

  15. [School shootings in Germany: current trends in the prevention of severe, targeted violence in German schools].

    Science.gov (United States)

    Bondü, Rebecca; Scheithauer, Herbert

    2009-01-01

    In March and September 2009 the school shootings in Winnenden and Ansbach once again demonstrated the need for preventive approaches in order to prevent further offences in Germany. Due to the low frequency of such offences and the low specificity of relevant risk factors known so far, prediction and prevention seems difficult though. None the less, several preventive approaches are currently discussed. The present article highlights these approaches and their specific advantages and disadvantages. As school shootings are multicausally determined, approaches focussing only on single aspects (i.e. prohibiting violent computer games or further strengthening gun laws) do not meet requirements. Other measures such as installing technical safety devices or optimizing actions of police and school attendants are supposed to reduce harm in case of emergency. Instead, scientifically founded and promising preventive approaches focus on secondary prevention and for this purpose employ the threat assessment approach, which is widespread within the USA. In this framework, responsible occupational groups such as teachers, school psychologists and police officers are to be trained in identifying students' warning signs, judging danger of these students for self and others in a systematic process and initiating suitable interventions.

  16. Current trends of human infections and antibiotic resistance of the genus Shewanella.

    Science.gov (United States)

    Yousfi, K; Bekal, S; Usongo, V; Touati, A

    2017-08-01

    Shewanella spp. are commonly known as environmental bacteria and are most frequently isolated from aquatic areas. Currently, diseases syndromes and multidrug resistance have increasingly been reported in the genus Shewanella. Some species are associated with various infections, such as skin and soft tissue infections, as well as bacteremia. Generally, these bacteria are opportunistic and mostly affect people with an impaired immune system. This genus is also a probable vehicle and progenitor of antibiotic resistance genes. In fact, several resistance genes and mobile genetic elements have been identified in some resistant species isolated from environmental or clinical settings. These genes confer resistance to different antibiotic classes, including those used in therapies such as β-lactams and quinolones, and are generally located on the chromosome. Recently, a multidrug-resistant (MDR) plasmid harboring several drug resistance genes associated with transposons and integrons has been identified in Shewanella xiamenensis. These antibiotic resistance genes can circulate in the environment and contribute to the emergence of antibiotic resistance. This review describes different aspects of Shewanella, focusing on the infections caused by this genus, as well as their role in the propagation of antibiotic resistance via mobile genetic elements.

  17. The Molecular Biology of Soft-Tissue Sarcomas and Current Trends in Therapy

    Directory of Open Access Journals (Sweden)

    Jorge Quesada

    2012-01-01

    Full Text Available Basic research in sarcoma models has been fundamental in the discovery of scientific milestones leading to a better understanding of the molecular biology of cancer. Yet, clinical research in sarcoma has lagged behind other cancers because of the multiple clinical and pathological entities that characterize sarcomas and their rarity. Sarcomas encompass a very heterogeneous group of tumors with diverse pathological and clinical overlapping characteristics. Molecular testing has been fundamental in the identification and better definition of more specific entities among this vast array of malignancies. A group of sarcomas are distinguished by specific molecular aberrations such as somatic mutations, intergene deletions, gene amplifications, reciprocal translocations, and complex karyotypes. These and other discoveries have led to a better understanding of the growth signals and the molecular pathways involved in the development of these tumors. These findings are leading to treatment strategies currently under intense investigation. Disruption of the growth signals is being targeted with antagonistic antibodies, tyrosine kinase inhibitors, and inhibitors of several downstream molecules in diverse molecular pathways. Preliminary clinical trials, supported by solid basic research and strong preclinical evidence, promises a new era in the clinical management of these broad spectrum of malignant tumors.

  18. Genetic linkage mapping in fungi: current state, applications, and future trends.

    Science.gov (United States)

    Foulongne-Oriol, Marie

    2012-08-01

    Genetic mapping is a basic tool for eukaryotic genomic research. Linkage maps provide insights into genome organization and can be used for genetic studies of traits of interest. A genetic linkage map is a suitable support for the anchoring of whole genome sequences. It allows the localization of genes of interest or quantitative trait loci (QTL) and map-based cloning. While genetic mapping has been extensively used in plant or animal models, this discipline is more recent in fungi. The present article reviews the current status of genetic linkage map research in fungal species. The process of linkage mapping is detailed, from the development of mapping populations to the construction of the final linkage map, and illustrated based on practical examples. The range of specific applications in fungi is browsed, such as the mapping of virulence genes in pathogenic species or the mapping of agronomically relevant QTL in cultivated edible mushrooms. Future prospects are finally discussed in the context of the most recent advances in molecular techniques and the release of numerous fungal genome sequences.

  19. Current trends in pulp therapy: a survey analyzing pulpotomy techniques taught in pediatric dental residency programs.

    Science.gov (United States)

    Walker, Laquia A; Sanders, Brian J; Jones, James E; Williamson, C Andrew; Dean, Jeffrey A; Legan, Joseph J; Maupome, Gerardo

    2013-01-01

    The study's purpose was to survey directors of pediatric dental residency programs in order to evaluate the materials currently being taught and used for pulpotomy procedures for primary teeth in educational and clinical settings. A web-based survey was emailed to all graduate pediatric dental residency program directors in the United States. Seventy one emails were sent to program directors, 47 responded but only 39 respondents (55%) were included in the study. Results suggested a slight decrease in utilization of formocresol 1:5 dilution (Pformocresol (18% of respondents) were systemic health concerns and carcinogenicity, in addition to evidence-based literature. Even though 25% of respondents have begun to use MTA for primary pulpotomy procedures, the most common reason for utilization of other medicaments over MTA was its higher cost. With 82% of graduate pediatric dental residency programs still utilizing formocresol 1:5 dilution for pulpotomy procedures in primary teeth, there has been no major shift away from its clinical use, in spite of increased usage of newer medicaments over the last 5 years.

  20. Towards the design of 3D multiscale instructive tissue engineering constructs: Current approaches and trends.

    Science.gov (United States)

    Oliveira, Sara M; Reis, Rui L; Mano, João F

    2015-11-01

    The design of 3D constructs with adequate properties to instruct and guide cells both in vitro and in vivo is one of the major focuses of tissue engineering. Successful tissue regeneration depends on the favorable crosstalk between the supporting structure, the cells and the host tissue so that a balanced matrix production and degradation are achieved. Herein, the major occurring events and players in normal and regenerative tissue are overviewed. These have been inspiring the selection or synthesis of instructive cues to include into the 3D constructs. We further highlight the importance of a multiscale perception of the range of features that can be included on the biomimetic structures. Lastly, we focus on the current and developing tissue-engineering approaches for the preparation of such 3D constructs: top-down, bottom-up and integrative. Bottom-up and integrative approaches present a higher potential for the design of tissue engineering devices with multiscale features and higher biochemical control than top-down strategies, and are the main focus of this review. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Persistent Spin Current in a Hard-Wall Confining Quantum Wire with Weak Dresselhaus Spin-Orbit Coupling

    Institute of Scientific and Technical Information of China (English)

    FU Xi; ZHOU Guang-Hui

    2009-01-01

    We investigate theoretically the spin current in a quantum wire with weak Dresselhaus spin-orbit coupling connected to two normal conductors.Both the quantum wire and conductors are described by a hard-wall confining potential.Using the electron wave-functions in the quantum wire and a new definition of spin current, we have calculated the elements of linear spin current density jTs,xi and jTs,yi(I = x, y, z).We lind that the elements jTs,xx and jTs,yy have a antisymmetrical relation and the element jTs,yz has the same amount level jTs,xx and jTs,yy.We also find a net linear spin current density, which has peaks at the center of quantum wire.The net linear spin current can induce a linear electric field, which may imply a way of spin current detection.

  2. Current Trend of Robotic Thoracic and Cardiovascular Surgeries in Korea: Analysis of Seven-Year National Data

    Science.gov (United States)

    Kang, Chang Hyun; Bok, Jin San; Lee, Na Rae; Kim, Young Tae; Lee, Seon Heui; Lim, Cheong

    2015-01-01

    Background Robotic surgery is an alternative to minimally invasive surgery. The aim of this study was to report on current trends in robotic thoracic and cardiovascular surgical techniques in Korea. Methods Data from the National Evidence-based Healthcare Collaborating Agency (NECA) between January 2006 and June 2012 were used in this study, including a total of 932 cases of robotic surgeries reported to NECA. The annual trends in the case volume, indications for robotic surgery, and distribution by hospitals and surgeons were analyzed in this study. Results Of the 932 cases, 591 (63%) were thoracic operations and 340 (37%) were cardiac operations. The case number increased explosively in 2007 and 2008. However, the rate of increase regained a steady state after 2011. The main indications for robotic thoracic surgery were pulmonary disease (n=271, 46%), esophageal disease (n=199, 34%), and mediastinal disease (n=117, 20%). The main indications for robotic cardiac surgery were valvular heart disease (n=228, 67%), atrial septal defect (n=79, 23%), and cardiac myxoma (n=27, 8%). Robotic thoracic and cardiovascular surgeries were performed in 19 hospitals. Three large volume hospitals performed 94% of the case volume of robotic cardiac surgery and 74% of robotic thoracic surgery. Centralization of robotic operation was significantly (probotic surgeries. However, only 27% of cardiac surgeons and 23% of thoracic surgeons performed more than 10 cases of robotic surgery. Conclusion Trend analysis of robotic and cardiovascular operations demonstrated a gradual increase in the surgical volume in Korea. Meanwhile, centralization of surgical cases toward specific surgeons in specific hospitals was observed. PMID:26509124

  3. Spatiotemporal variability and long-term trends of ocean acidification in the California Current System

    Directory of Open Access Journals (Sweden)

    C. Hauri

    2012-08-01

    Full Text Available Due to seasonal upwelling, the upper ocean waters of the California Current System (CCS have a naturally low pH and aragonite saturation state (Ωarag, making this region particularly prone to the effects of ocean acidification. Here, we use the Regional Oceanic Modeling System (ROMS to conduct preindustrial and transient (1995–2050 simulations of ocean biogeochemistry in the CCS. The transient simulations were forced with increasing atmospheric pCO2 as projected by the NCAR CSM 1.4 model run under either the IPCC SRES A2 or B1 scenarios. Using ROMS, we investigate the timing of transition decades during which pH and Ωarag depart from their modeled preindustrial (1750 and present-day (2011 variability envelopes. We report these transition decades by noting the midpoint of the ten-year transition periods. In addition, we also analyze the timing of near permanent aragonite undersaturation in the upper 100 m of the water column. Our results show that an interplay of physical and biogeochemical processes create large seasonal variability in pH (∼ 0.14 and Ωarag (∼ 0.2. Despite this large variability, we find that present-day pH and Ωarag have already moved out of their preindustrial variability envelopes due to the rapidly increasing concentrations of atmospheric CO2. The simulations following the A2 emissions scenario suggest that nearshore surface pH of the northern and central CCS will move out of their present-day variability envelopes by 2045 and 2037, respectively. However, surface Ωarag of the northern and central CCS subregions are projected to depart from their present-day variability envelopes sooner, by 2030 and 2035, respectively. By 2025, the aragonite saturation horizon of the central CCS is projected to shoal into the upper 75 m for the duration of the annual cycle, causing near permanent undersaturation in subsurface waters. Overall, our

  4. Spatiotemporal variability and long-term trends of ocean acidification in the California Current System

    Directory of Open Access Journals (Sweden)

    C. Hauri

    2013-01-01

    Full Text Available Due to seasonal upwelling, the upper ocean waters of the California Current System (CCS have a naturally low pH and aragonite saturation state (Ωarag, making this region particularly prone to the effects of ocean acidification. Here, we use the Regional Oceanic Modeling System (ROMS to conduct preindustrial and transient (1995–2050 simulations of ocean biogeochemistry in the CCS. The transient simulations were forced with increasing atmospheric pCO2 and increasing oceanic dissolved inorganic carbon concentrations at the lateral boundaries, as projected by the NCAR CSM 1.4 model for the IPCC SRES A2 scenario. Our results show a large seasonal variability in pH (range of ~ 0.14 and Ωarag (~ 0.2 for the nearshore areas (50 km from shore. This variability is created by the interplay of physical and biogeochemical processes. Despite this large variability, we find that present-day pH and Ωarag have already moved outside of their simulated preindustrial variability envelopes (defined by ±1 temporal standard deviation due to the rapidly increasing concentrations of atmospheric CO2. The nearshore surface pH of the northern and central CCS are simulated to move outside of their present-day variability envelopes by the mid-2040s and late 2030s, respectively. This transition may occur even earlier for nearshore surface Ωarag, which is projected to depart from its present-day variability envelope by the early- to mid-2030s. The aragonite saturation horizon of the central CCS is projected to shoal into the upper 75 m within the next 25 yr, causing near-permanent undersaturation in subsurface waters. Due to the model's overestimation of Ωarag, this transition may occur even earlier than simulated by the model. Overall, our study shows that the CCS joins the Arctic and Southern oceans as one of only a few known ocean regions presently approaching the dual threshold of

  5. Computer Assisted Surgery and Current Trends in Orthopaedics Research and Total Joint Replacements

    Science.gov (United States)

    Amirouche, Farid

    2008-06-01

    Musculoskeletal research has brought about revolutionary changes in our ability to perform high precision surgery in joint replacement procedures. Recent advances in computer assisted surgery as well better materials have lead to reduced wear and greatly enhanced the quality of life of patients. The new surgical techniques to reduce the size of the incision and damage to underlying structures have been the primary advance toward this goal. These new techniques are known as MIS or Minimally Invasive Surgery. Total hip and knee Arthoplasties are at all time high reaching 1.2 million surgeries per year in the USA. Primary joint failures are usually due to osteoarthristis, rheumatoid arthritis, osteocronis and other inflammatory arthritis conditions. The methods for THR and TKA are critical to initial stability and longevity of the prostheses. This research aims at understanding the fundamental mechanics of the joint Arthoplasty and providing an insight into current challenges in patient specific fitting, fixing, and stability. Both experimental and analytical work will be presented. We will examine Cementless total hip arthroplasty success in the last 10 years and how computer assisted navigation is playing in the follow up studies. Cementless total hip arthroplasty attains permanent fixation by the ingrowth of bone into a porous coated surface. Loosening of an ingrown total hip arthroplasty occurs as a result of osteolysis of the periprosthetic bone and degradation of the bone prosthetic interface. The osteolytic process occurs as a result of polyethylene wear particles produced by the metal polyethylene articulation of the prosthesis. The total hip arthroplasty is a congruent joint and the submicron wear particles produced are phagocytized by macrophages initiating an inflammatory cascade. This cascade produces cytokines ultimately implicated in osteolysis. Resulting bone loss both on the acetabular and femoral sides eventually leads to component instability. As

  6. Ovarian preservation in children for adenexal pathology, current trends in laparoscopic management and our experience

    Directory of Open Access Journals (Sweden)

    Preet Agarwal

    2014-01-01

    follow-up ultrasound, who were found to have normal shape, size and blood flow compared to the contra lateral side. Conclusion: We outline our experience from the management of 46 cases of various ovarian pathologies with and without ischemia and found that ovarian torsion with a benign pathology and ischemia is not a contraindication for ovarian preservation, as pointed out in the current literature.

  7. Current trends in candidemia and species distribution among adults: Candida glabrata surpasses C. albicans in diabetic patients and abdominal sources.

    Science.gov (United States)

    Khatib, Riad; Johnson, Leonard B; Fakih, Mohamad G; Riederer, Kathleen; Briski, Laurence

    2016-07-12

    Candidemia rate and species distribution vary according to the type of patients, country of origin and antifungal prophylaxis use. To present current candidemia epidemiological trends. A retrospective examination of candidemia in adults (≥18 years-old) hospitalised from 2007 to 2015. Cases were identified through the microbiology laboratory. Candida species were distinguished based on colony morphology and VITEK-2 YBC cards, (bioMerieux, Durham, NC, USA). Patient characteristics, species distribution, source and outcome were assessed. We encountered 275 patients (294 episodes) with candidemia. The rate of candidemia dropped in 2010 (P = 0.003) without further decline. Nearly all cases (97.5%) were healthcare-associated. C. albicans (n = 118) and C. glabrata (n = 77) proportions varied without a discernable trend. C. glabrata was more common in diabetics [52.9% vs. 32.0% (non-diabetics); P = 0.004] and abdominal sources [53.3% vs. 35.5% (other sources); P = 0.03], especially gastric/duodenal foci [88.9% vs. 44.1% (other abdominal foci); P = 0.02]. All-cause 30-day mortality rate was 43.3% without changes over time or differences between C. albicans and C. glabrata. In conclusion, the candidemia rate remains stable after a decline in 2010. C. albicans remains the most common species but C. glabrata predominates in diabetics and abdominal sources. These findings suggest possible species-related differences in colonisation dynamics or pathogenicity. © 2016 Blackwell Verlag GmbH.

  8. Current levels and trends of radioactive contamination of aquatic ecosystem components in the Chernobyl exclusion zone

    Energy Technology Data Exchange (ETDEWEB)

    Gudkov, Dmitri I.; Kaglyan, Alexander Ye.; Ganzha, Kristina D.; Klenus, Vasiliy G. [Institute of Hydrobiology, Geroyev Stalingrada Ave. 12, UA-04210 Kiev (Ukraine); Kireev, Sergey I.; Nazarov, Alexander B. [Chernobyl Specialized Enterprise, Radyanska Str. 70, UA-07270 Chernobyl (Ukraine)

    2014-07-01

    The current radiation level and its composition in aquatic ecosystems within the Chernobyl exclusion zone (ChEZ) are conditioned, above all things, by the amount of radioactive matters released as aerosols on a water surface and adjacent territories during the period of the active phase of the accident from destroyed of the Chernobyl NPP in 1986, and also by intensity and duration of the second processes of radionuclides washout from the catchment areas and hydrodynamic processes of their transport outside of water bodies. During last 10-15 years in the soils of the ChEZ the tendency of increase of yield of the mobile bioavailable forms of radionuclides, which released into hydrological systems with surface and ground waters or localized in the closed water systems, where quickly involving in the biotic cycle is marked. On the example of lakes of the Krasnensky flood plain of the Pripyat River, which is one of the most contaminated by radionuclides territory of the ChEZ, was determined that the basic amount of radionuclides in lake ecosystem is deposited in the bottom sediments: {sup 90}Sr - 89-95%, {sup 137}Cs - 99%, transuranium elements (TUE) {sup 238}Pu, {sup 239+240}Pu and {sup 241}Am - almost 100% of the total radionuclide amount in ecosystem. The increased migration activity of {sup 90}Sr determines its more high quantity in water (4-10%) on comparison with {sup 137}Cs (0.5-0.6%) and TUE (0.03-0.04%) and, opposite, less - in seston (0.15-0.16%) on comparison with {sup 137}Cs (0.25-0.30%). The value of {sup 90}Sr in biotic component amounts 0.25-0.61%, {sup 137}Cs - 0.14-0.47% and TUE - 0.07-0.16% of the total quantity in ecosystem. The gradual decline of radionuclide specific activity is a dominant tendency in the dynamics of {sup 137}Cs and {sup 90}Sr in water and aquatic biota of the majority of reservoirs and water flow in the ChEZ. The exception is water bodies, located on the dammed territories of the Krasnensky flood plain, where at the proceeding

  9. 通信网的现状及发展趋势%CURRENT SITUATION AND DEVELOPMENT TREND OF COMMUNICATION NETWORK

    Institute of Scientific and Technical Information of China (English)

    毕永军; 尹传平; 林孝康

    2001-01-01

    The current status of the computer network, cable TV network andpublic switched telephone network is analyzed. The integration of the three kinds of networks has become an inevitable trend along with the development of the computer network. Several solutions to that network integration are discussed. Some suggestions are also given about using ATM core network to construct the next generation electric power communication network as a better solution and implementing the IP service by multiple protocol label switching (MPLS) technique.%分析了计算机网、有线电视网、电话网的现状,指出三网融合是通信网发展的必然趋势;分析了三网融合的几种方案;对于电力通信网提出了建设ATM核心骨干网,以MPLS实现IP业务的建议。

  10. Streamflow trend analysis by considering autocorrelation structure, long-term persistence, and Hurst coefficient in a semi-arid region of Iran

    Science.gov (United States)

    Zamani, Reza; Mirabbasi, Rasoul; Abdollahi, Sajjad; Jhajharia, Deepak

    2017-07-01

    Due to the substantial decrease of water resources as well as the increase in demand and climate change phenomenon, analyzing the trend of hydrological parameters is of paramount importance. In the present study, investigations were carried out to identify the trends in streamflow at 20 hydrometric stations and 11 rainfall gauging stations located in Karkheh River Basin (KRB), Iran, in monthly, seasonal, and annual time scales during the last 38 years from 1974 to 2011. This study has been conducted using two versions of Mann-Kendall tests, including (i) Mann-Kendall test by considering all the significant autocorrelation structure (MK3) and (ii) Mann-Kendall test by considering LTP and Hurst coefficient (MK4). The results indicate that the KRB streamflow trend (using both test versions) has decreased in all three time scales. There is a significant decreasing trend in 78 and 73 % of the monthly cases using the MK3 and MK4 tests, respectively, while these percentages changed to 80 and 70 % on seasonal and annual time scales, respectively. Investigation of the trend line slope using Theil-Sen's estimator showed a negative trend in all three time scales. The use of MK4 test instead of the MK3 test has caused a decrease in the significance level of Mann-Kendall Z-statistic values. The results of the precipitation trends indicate both increasing and decreasing trends. Also, the correlation between the area average streamflow and precipitation shows a strong correlation in annual time scale in the KRB.

  11. [Adolescent contraception. Current trends].

    Science.gov (United States)

    Anthuber, Sabine

    2005-10-01

    Despite easy availability of contraception, Germany is confronted with the problem of increasing rates of pregnancies and abortions in minors. Prescription of contraceptives that do not rely on compliance and are acceptable to adolescents is required in addition to improved counseling. For that purpose, adherence to the guidelines for the use of contraceptives in minors written by the consortium for legislation in medicine (AG Medizinrecht) is essential. Oral contraceptives are the most commonly prescribed form of birth control, advantages include reversibility as well as a good tolerance and safety profile. New developments are low-dose compounds, novel progestins, prevention of ovulation by pure gestagen pills and the long-term use of low-dose monophasic micro pills. Long-term contraceptives like subdermally implantable depot compounds or hormone-releasing pessaries in utero have been used on a regular basis and seem a convenient alternative for birth control for longer periods, also in adolescents. The easy-to-use intravaginal ring and the birth control patch have expanded the spectrum of hormone-releasing contraceptive systems. Studies show improved compliance and a possible reduction of unintentional pregnancies due to application errors. Amelioration of the range of highly effective birth control products different modes of application will hopefully lead to drop in the rate of unplanned pregnancies, especially in adolescents.

  12. Saikosaponin a mediates the anticonvulsant properties in the HNC models of AE and SE by inhibiting NMDA receptor current and persistent sodium current.

    Directory of Open Access Journals (Sweden)

    Yun-Hong Yu

    Full Text Available Epilepsy is one of the most common neurological disorders, yet its treatment remains unsatisfactory. Saikosaponin a (SSa, a triterpene saponin derived from Bupleurum chinensis DC., has been demonstrated to have significant antiepileptic activity in a variety of epilepsy models in vivo. However, the electrophysiological activities and mechanisms of the antiepileptic properties of SSa remain unclear. In this study, whole-cell current-clamp recordings were used to evaluate the anticonvulsant activities of SSa in the hippocampal neuronal culture (HNC models of acquired epilepsy (AE and status epilepticus (SE. Whole-cell voltage-clamp recordings were used to evaluate the modulation effects of SSa on NMDA-evoked current and sodium currents in cultured hippocampal neurons. We found that SSa effectively terminated spontaneous recurrent epileptiform discharges (SREDs in the HNC model of AE and continuous epileptiform high-frequency bursts (SE in the HNC model of SE, in a concentration-dependent manner with an IC(50 of 0.42 µM and 0.62 µM, respectively. Furthermore, SSa significantly reduced the peak amplitude of NMDA-evoked current and the peak current amplitude of I(NaP. These results suggest for the first time that the inhibitions of NMDA receptor current and I(NaP may be the underlying mechanisms of SSa's anticonvulsant properties, including the suppression of SREDs and SE in the HNC models of AE and SE. In addition, effectively abolishing the refractory SE implies that SSa may be a potential anticonvulsant candidate for the clinical treatment of epilepsy.

  13. Taxonomic and functional composition of the algal benthos exhibits similar successional trends in response to nutrient supply and current velocity.

    Science.gov (United States)

    Larson, Chad A; Passy, Sophia I; Laanbroek, Riks

    2012-05-01

    In an effort to identify the causes and patterns of temporal change in periphytic communities, we examined biomass accumulation, taxonomic and functional composition, rate of species turnover, and pairwise species correlations in response to variability in current velocity and nutrient supply in artificial stream flumes. Divergent patterns in community growth and succession were observed between nutrient treatments and, to a lesser extent, between flow treatments best described by shifts in taxonomic and functional composition. Specifically, understory low profile species, tolerant to low resource supply, became dominant under low nutrients, while overstory high profile and motile species with higher nutrient demands dominated the high nutrient treatments. Increased resource supply or current velocity did not influence the species turnover rate, measured by a time-lag analysis. Interspecific interactions, especially competition, did not appear to be driving community dynamics, as the number of positive and negative pairwise species correlations ranged between low and extremely low, respectively. The overwhelming majority of correlations were not significant, indicating that species within the biofilm matrix were not perceptibly influencing one another. Thus, temporal trends in taxonomic and functional composition were largely environmentally driven, signifying that coexistence in biofilms is defined by the same mechanism along the hierarchy from species to functional groups.

  14. The changing health care marketplace: current industry trends, new provider organizational structures, and effects on plastic surgeons.

    Science.gov (United States)

    Krieger, L M

    1998-09-01

    Current market forces are driving the health care industry in new directions. The managed care industry is currently undergoing a market shakeout, as manifested by consolidation, increased competition, and lower profits. Medicare is fighting to remain solvent by lowering fees paid to providers, driving patients into managed care plans, and cracking down on billing irregularities. For providers, the combined effect of these trends is lower fees, increased risk-sharing, and increased overhead. Plastic surgeons face new demands in this environment. They must increase their efficiency and form new alliances with other providers. These alliances allow plastic surgeons to maintain a steady stream of patients, to manage risk, to negotiate more lucrative contracts with managed care organizations, and to increase efficiency. To achieve these alliances, plastic surgeons must alter the organizational structure of their practices. Several corporate practice models are becoming more prevalent; these include large group practices, physician practice management companies, and integrated delivery systems. Each structure has advantages for plastic surgeons, but each also requires plastic surgeons to trade varying degrees of financial and professional autonomy for market strength.

  15. Development of a Current Fit Function for NbTi to be Used for Calculation of Persistent Current Induced Field Errors in the LHC Main Dipoles

    CERN Document Server

    Schwerg, N

    2006-01-01

    A new fit function for the critical current density of superconducting NbTi cables for the LHC main dipoles is presented. Existing fit functions usually show a good matching of the very low field range, but produce a current density which is significantly too small for the intermediate and high field range. Consequently the multipole range measured at cold is only partially reproduced and loops from current cycling do not match. The presented function is used as input for the field quality calculation of a complete magnet cross-section including arbitrary current cycling and all hysteresis effects. This way allows to trace a so-called finger-print of the cable combination used in the LHC main bending magnets. The finger-print pattern is a consequence of the differences of the measured superconductor magnetization of cables from different manufacturers. The simulation results have been compared with measurements at cold obtained from LHC main dipoles and a very good agreement for low and intermediate field val...

  16. Application of current knowledge and trends in sports training of top level volleyball teams in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Michal Lehnert

    2010-01-01

    Full Text Available BACKGROUND: To achieve the best results in top volleyball it is necessary to analyze the current state and to react adequately to development trends, which characterize modern volleyball. OBJECTIVES: The goal of the study was to acquire information regarding how do top volleyball coaches of senior and junior volleyball teams in the Czech Republic put current knowledge and trends in volleyball sport training and coaching in practice. METHODS: We created a survey consisting of 31 questions, which were divided into 5 areas: respecting of the current requirements of game performance in training, training efficiency, conditioning, coaching and psycho-social aspects. The survey was sent to 49 coaches, 24 of them replied (response rate 49 %. RESULTS: The research shows that coaches do not apply all important knowledge and trends for players' preparation (76 % of correct answers in total. Groups of coaches were further divided to subgroups according to gender of the trained teams, age categories, coaches work load and 1st and 2nd class coaches. The comparison of the answers in the subgroup of coaches with respect to segregated areas has only pointed at a difference between male and female teams in the area of psycho-social training aspects (Z = 1.756; p = 0.079; d = 0.717. The comparison of coaches' groups answers to individual questions show that: a coaches of male teams base their training sessions on real game situations and choose the content of the exercises with the ball more thoroughly (Z = 1.85; p = 0.07; d = 0.75 and require defensive game combinations at the net more often (Z = 1.81; p = 0.07; d = 0.74; b junior teams are behind (Z = 1.90; p = 0.06; d = 0.77 senior teams in the number of training hours with the ball a week and in making conditions for successful realization of offensive game combinations with fast set (Z = 2.10; p = 0.04; d = 0.86; c 1st class coaches within the scope of condition training pay more attention to core training

  17. Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons

    Directory of Open Access Journals (Sweden)

    Klinger Alexandra B

    2012-09-01

    Full Text Available Abstract Background Gain-of-function mutations of the nociceptive voltage-gated sodium channel Nav1.7 lead to inherited pain syndromes, such as paroxysmal extreme pain disorder (PEPD. One characteristic of these mutations is slowed fast-inactivation kinetics, which may give rise to resurgent sodium currents. It is long known that toxins from Anemonia sulcata, such as ATX-II, slow fast inactivation and skin contact for example during diving leads to various symptoms such as pain and itch. Here, we investigated if ATX-II induces resurgent currents in sensory neurons of the dorsal root ganglion (DRGs and how this may translate into human sensations. Results In large A-fiber related DRGs ATX-II (5 nM enhances persistent and resurgent sodium currents, but failed to do so in small C-fiber linked DRGs when investigated using the whole-cell patch-clamp technique. Resurgent currents are thought to depend on the presence of the sodium channel β4-subunit. Using RT-qPCR experiments, we show that small DRGs express significantly less β4 mRNA than large sensory neurons. With the β4-C-terminus peptide in the pipette solution, it was possible to evoke resurgent currents in small DRGs and in Nav1.7 or Nav1.6 expressing HEK293/N1E115 cells, which were enhanced by the presence of extracellular ATX-II. When injected into the skin of healthy volunteers, ATX-II induces painful and itch-like sensations which were abolished by mechanical nerve block. Increase in superficial blood flow of the skin, measured by Laser doppler imaging is limited to the injection site, so no axon reflex erythema as a correlate for C-fiber activation was detected. Conclusion ATX-II enhances persistent and resurgent sodium currents in large diameter DRGs, whereas small DRGs depend on the addition of β4-peptide to the pipette recording solution for ATX-II to affect resurgent currents. Mechanical A-fiber blockade abolishes all ATX-II effects in human skin (e.g. painful and itch

  18. [The effect of enzymatic treatment using proteases on properties of persistent sodium current in CA1 pyramidal neurons of rat hippocampus].

    Science.gov (United States)

    Lun'ko, O O; Isaiev, D S; Maxymiuk, O P; Kryshtal', O O; Isaieva, O V

    2014-01-01

    We investigated the effect of proteases, widely used for neuron isolation in electrophysiological studies, on the amplitude and kinetic characteristics of persistent sodium current (I(NaP)) in hippocampal CA1 pyramidal neurons. Properties of I(NaP) were studied on neurons isolated by mechanical treatment (control group) and by mechanical and enzymatic treatment using pronase E (from Streptomyces griseus) or protease type XXIII (from Aspergillus oryzae). We show that in neurons isolated with pronase E kinetic of activation and density of I(NaP) was unaltered. Enzymatic treatment with protease type XXIII did not alter I(NaP) activation but result in significant decrease in I(NaP) density. Our data indicates that enzymatic treatment using pronase E for neuron isolation is preferable for investigation of I(NaP).

  19. Spread in Dipole Cable Magnetization and Consequences on the Spread of DC Persistent Currents in the Main Dipole of the Large Hadron Collider

    CERN Document Server

    Bellesia, B; Granata, V; Le Naour, S; Oberli, L R; Sanfilippo, S; Santoni, C; Scandale, Walter; Schwerg, N; Todesco, Ezio; Völlinger, C

    2004-01-01

    The production of more than 60% of superconducting cables for the main dipoles of the Large Hadron Collider has been completed. The results of the measurements of cable magnetization and the dependence on the manufacturer are presented. The strand magnetization produces field errors that have been measured in a large number of dipoles, all tested in cold conditions. We examine here the correlation between the available magnetic measurements and the large database of cable magnetization. The analysis is based on models documented in the literature. Finally, a forecast of the persistent current effects to be expected in the LHC main dipoles is presented, and the more critical parameters for beam dynamics are singled out.

  20. Current Status and Development Trend of Cloud Computing%云计算的现状与发展趋势

    Institute of Scientific and Technical Information of China (English)

    孙洪建

    2012-01-01

    云计算作为一个全新的概念产业日益受到世界各国政府和企业界的重视。全社会不仅对它投入了巨大的关注,更为了它的快速发展投入了大量的人、财、物。云计算带来的计算机应用方式的革命被业内专家寄于厚望,更有人将其称为继信息技术革命之后的第四次工业革命。文章对云计算在目前的发展状况进行了简要概括;重点对云计算目前发展阶段存在的各种瓶颈问题进行了归纳总结,对其成因进行了剖析;对云计算今后的发展、应用趋势进行了展望。%Cloud computing, as a brand new industry of conceptualization, gets increasingly attention from governments and enterprises around the world. Moreover the society pays great attention its rapid development and invests a lot of human power, financial and physical resources. The revolution of computer application mode brought by cloud computing has been placed great expectation by the experts, even more the-fourth-industrial-revolution after the-technology-revolution named by someone. This paper briefly summarizes the current situation of cloud computing development in China, focuses on conclusion of its development bottleneck at present stage, and analysis of its cause, and finally, this paper looks into the future of development and application trend.