WorldWideScience

Sample records for current treatment status

  1. Current status in diabetic macular edema treatments

    Institute of Scientific and Technical Information of China (English)

    Pedro; Romero-Aroca

    2013-01-01

    Diabetes is a serious chronic condition,which increase the risk of cardiovascular diseases,kidney failure and nerve damage leading to amputation.Furthermore the ocular complications include diabetic macular edema,is the leading cause of blindness among adults in the industrialized countries.Today,blindness from diabetic macular edema is largely preventable with timely detection and appropriate interventional therapy.The treatment should include an optimized control of glycemia,arterial tension,lipids and renal status.The photocoagulation laser is currently restricted to focal macular edema in some countries,but due the high cost of intravitreal drugs,the use of laser treatment for focal and diffuse diabetic macular edema(DME),can be valid as gold standard in many countries.The intravitreal anti vascular endothelial growth factor drugs(ranibizumab and bevacizumab),are indicated in the treatment of all types of DME,but the correct protocol for administration should be defined for the different Retina Scientific Societies.The corticosteroids for diffuse DME,has a place in pseudophakic patients,but its complications restricted the use of these drugs for some patients.Finally the intravitreal interface plays an important role and its exploration is mandatory in all DME patients.

  2. Current status and prospects of HIV treatment.

    Science.gov (United States)

    Cihlar, Tomas; Fordyce, Marshall

    2016-06-01

    Current antiviral treatments can reduce HIV-associated morbidity, prolong survival, and prevent HIV transmission. Combination antiretroviral therapy (cART) containing preferably three active drugs from two or more classes is required for durable virologic suppression. Regimen selection is based on virologic efficacy, potential for adverse effects, pill burden and dosing frequency, drug-drug interaction potential, resistance test results, comorbid conditions, social status, and cost. With prolonged virologic suppression, improved clinical outcomes, and longer survival, patients will be exposed to antiretroviral agents for decades. Therefore, maximizing the safety and tolerability of cART is a high priority. Emergence of resistance and/or lack of tolerability in individual patients require availability of a range of treatment options. Development of new drugs is focused on improving safety (e.g. tenofovir alafenamide) and/or resistance profile (e.g. doravirine) within the existing drug classes, combination therapies with improved adherence (e.g. single-tablet regimens), novel mechanisms of action (e.g. attachment inhibitors, maturation inhibitors, broadly neutralizing antibodies), and treatment simplification with infrequent dosing (e.g. long-acting injectables). In parallel with cART innovations, research and development efforts focused on agents that target persistent HIV reservoirs may lead to prolonged drug-free remission and HIV cure. Copyright © 2016 Gilead Sciences, Inc. Published by Elsevier B.V. All rights reserved.

  3. Current status of radiation treatment of water and wastewater

    International Nuclear Information System (INIS)

    Pikaev, A.K.

    1997-01-01

    This is a brief review of the current status of radiation treatment of surface water, groundwater, wastewaters, and sewage sludges. Sources of ionizing radiation, and combination radiation methods for purification are described in some detail. Special attention is paid to pilot and industrial facilities. (author)

  4. Current status of quality assurance of treatment planning systems

    International Nuclear Information System (INIS)

    Mijnheer, B.J.

    1997-01-01

    A review is given of the current status of quality assurance of treatment planning systems. At this moment only one comprehensive report is available. In order to review national activities a questionnaire has been distributed amongst national societies of medical physicists. From the 23 responding countries, 8 indicated that only limited efforts are underway, 8 answered that a working group is evaluating their specific national requirements while in 5 countries a document is drafted. The highlights of these reports have been summarized. (author)

  5. Current Diagnosis, Treatment and Etiology of Status Epilepticus

    Directory of Open Access Journals (Sweden)

    Çetin Kürşad Akpınar

    2014-03-01

    Full Text Available Status Epilepticus (SE is a medical emergency that causes significant morbidity and mortality and requires prompt diagnosis and treatment. Although SE can be divided into two subgroups as convulsive and nonconvulsive, treatment principles are generally similar. Treatment should be prompt and underlying cause should be corrected. Although intravenous lorazepam is the first-line treatment due to a lower risk of relapse, diazepam becomes the first choice since loeazepan is not available in our country. Even though intravenous benzodiazepine stops seizures, intravenous antiepileptic drug (phenytoin, etc. should be administered at a loading dose. Patients with refractory status epilepticus should be supported with respect to vital, respiratory, metabolic and hemodynamic aspects and followed up in an intensive care unit to monitor cerebral electrical activity. The most common cause in the etiology is the cessation of antiepileptic drugs. The aim of SE treatment is to stop seizures and prevent complications and recurrence. In this paper, current diagnosis, treatment and etiology of SE are reviewed.

  6. Current status of brachytherapy in cancer treatment – short overview

    Directory of Open Access Journals (Sweden)

    Janusz Skowronek

    2017-12-01

    Full Text Available Cancer incidence and mortality depend on a number of factors, including age, socio-economic status and geographical location, and its prevalence is growing around the world. Most of cancer treatments include external beam radiotherapy or brachytherapy. Brachytherapy, a type of radiotherapy with energy from radionuclides inserted directly into the tumor, is increasingly used in cancer treatment. For cervical and skin cancers, it has become a standard therapy for more than 100 years as well as an important part of the treatment guidelines for other malignancies, including head and neck, skin, breast, and prostate cancers. Compared to external beam radiotherapy, brachytherapy has the potential to deliver an ablative radiation dose over a short period of time directly to the altered tissue area with the advantage of a rapid fall-off in dose, and consequently, sparing of adjacent organs. As a result, the patient is able to complete the treatment earlier, and the risks of occurrence of another cancer are lower than in conventional radiotherapy treatment. Brachytherapy has increased its use as a radical or palliative treatment, and become more advanced with the spread of pulsed-dose-rate and high-dose-rate afterloading machines; the use of new 3D/4D planning systems has additionally improved the quality of the treatment. The aim of the present study was to present short summaries of current studies on brachytherapy for the most frequently diagnosed tumors. Data presented in this manuscript should help especially young physicians or physicists to explore and introduce brachytherapy in cancer treatments.

  7. Gastric Cancer: Current Status of Diagnosis and Treatment

    International Nuclear Information System (INIS)

    Takahashi, Tsunehiro; Saikawa, Yoshiro; Kitagawa, Yuko

    2013-01-01

    Gastric cancer is the second leading cause of death from malignant disease worldwide and most frequently discovered in advanced stages. Because curative surgery is regarded as the only option for cure, early detection of resectable gastric cancer is extremely important for good patient outcomes. Therefore, noninvasive diagnostic modalities such as evolutionary endoscopy and positron emission tomography are utilized as screening tools for gastric cancer. To date, early gastric cancer is being treated using minimally invasive methods such as endoscopic treatment and laparoscopic surgery, while in advanced cancer it is necessary to consider multimodality treatment including chemotherapy, radiotherapy, and surgery. Because of the results of large clinical trials, surgery with extended lymphadenectomy could not be recommended as a standard therapy for advanced gastric cancer. Recent clinical trials had shown survival benefits of adjuvant chemotherapy after curative resection compared with surgery alone. In addition, recent advances of molecular targeted agents would play an important role as one of the modalities for advanced gastric cancer. In this review, we summarize the current status of diagnostic technology and treatment for gastric cancer

  8. Current status in the treatment options for esophageal achalasia.

    Science.gov (United States)

    Chuah, Seng-Kee; Chiu, Chien-Hua; Tai, Wei-Chen; Lee, Jyong-Hong; Lu, Hung-I; Changchien, Chi-Sin; Tseng, Ping-Huei; Wu, Keng-Liang

    2013-09-07

    Recent advances in the treatment of achalasia include the use of high-resolution manometry to predict the outcome of patients and the introduction of peroral endoscopic myotomy (POEM). The first multicenter randomized, controlled, 2-year follow-up study conducted by the European Achalasia Trial group indicated that laparoscopic Heller myotomy (LHM) was not superior to pneumatic dilations (PD). Publications on the long-term success of laparoscopic surgery continue to emerge. In addition, laparoscopic single-site surgery is applicable to advanced laparoscopic operations such as LHM and anterior fundoplication. The optimal treatment option is an ongoing matter of debate. In this review, we provide an update of the current progress in the treatment of esophageal achalasia. Unless new conclusive data prove otherwise, LHM is considered the most durable treatment for achalasia at the expense of increased reflux-associated complications. However, PD is the first choice for non-surgical treatment and is more cost-effective. Repeated PD according to an "on-demand" strategy based on symptom recurrence can achieve long-term remission. Decision making should be based on clinical evidence that identifies a subcategory of patients who would benefit from specific treatment options. POEM has shown promise but its long-term efficacy and safety need to be assessed further.

  9. Current Status of Interventional Radiology Treatment of Infrapopliteal Arterial Disease

    Energy Technology Data Exchange (ETDEWEB)

    Rand, T., E-mail: thomas.rand@wienkav.at [General Hospital Hietzing, Department of Radiology (Austria); Uberoi, R. [John Radcliffe Hospital, Department of Radiology (United Kingdom)

    2013-06-15

    Treatment of infrapopliteal arteries has developed to a standard technique during the past two decades. With the introduction of innovative devices, a variety of techniques has been created and is still under investigation. Treatment options range from plain balloon angioplasty (POBA), all sorts of stent applications, such as bare metal, balloon expanding, self-expanding, coated and drug-eluting stents, and bio-absorbable stents, to latest developments, such as drug-eluting balloons. Regarding the scientific background, several prospective, randomized studies with relevant numbers of patients have been (or will be) published that are Level I evidence. In contrast to older studies, which primarily were based mostly on numeric parameters, such as diameters or residual stenoses, more recent study concepts focus increasingly on clinical features, such as amputation rate improvement or changes of clinical stages and quality of life standards. Although it is still not decided, which of the individual techniques might be the best one, we can definitely conclude that whatever treatment of infrapopliteal arteries will be used it is of substantial benefit for the patient. Therefore, the goal of this review is to give an overview about the current developments and techniques for the treatment of infrapopliteal arteries, to present clinical and technical results, to weigh individual techniques, and to discuss the recent developments.

  10. Current Status of Interventional Radiology Treatment of Infrapopliteal Arterial Disease

    International Nuclear Information System (INIS)

    Rand, T.; Uberoi, R.

    2013-01-01

    Treatment of infrapopliteal arteries has developed to a standard technique during the past two decades. With the introduction of innovative devices, a variety of techniques has been created and is still under investigation. Treatment options range from plain balloon angioplasty (POBA), all sorts of stent applications, such as bare metal, balloon expanding, self-expanding, coated and drug-eluting stents, and bio-absorbable stents, to latest developments, such as drug-eluting balloons. Regarding the scientific background, several prospective, randomized studies with relevant numbers of patients have been (or will be) published that are Level I evidence. In contrast to older studies, which primarily were based mostly on numeric parameters, such as diameters or residual stenoses, more recent study concepts focus increasingly on clinical features, such as amputation rate improvement or changes of clinical stages and quality of life standards. Although it is still not decided, which of the individual techniques might be the best one, we can definitely conclude that whatever treatment of infrapopliteal arteries will be used it is of substantial benefit for the patient. Therefore, the goal of this review is to give an overview about the current developments and techniques for the treatment of infrapopliteal arteries, to present clinical and technical results, to weigh individual techniques, and to discuss the recent developments.

  11. Current status of atypical antipsychotics for the treatment of fibromyalgia.

    Science.gov (United States)

    Rico-Villademoros, F; Calandre, E P; Slim, M

    2014-06-01

    The treatment of fibromyalgia requires pharmacological and nonpharmacological therapies. The pharmacological treatment of fibromyalgia is limited to a few drugs that have been demonstrated to be moderately effective in some but not all dimensions of the disease. Therefore, the search for new drugs to treat this condition is warranted. Atypical antipsychotics offered an attractive alternative because they had been shown to be active against several key symptoms of fibromyalgia. The results of open-label studies, however, appear to indicate that atypical antipsychotics are poorly tolerated in patients with fibromyalgia, and only quetiapine XR has been studied in randomized controlled trials. Quetiapine XR has demonstrated effectiveness in treating comorbid major depression, anxiety and sleep disturbance. However, in two randomized controlled trials, quetiapine XR was not differentiated from placebo and failed to demonstrate noninferiority to amitriptyline in terms of improving overall symptomatology. The effect of quetiapine XR on pain and its usefulness as part of a combination pharmacological regimen should be further evaluated. Overall, the use of quetiapine (initiated at a low dose and slowly titrated) in fibromyalgia should be limited to patients with comorbid major depression or patients who are currently receiving other treatments and have unresolved and disabling depressive and/or anxiety symptoms. Copyright 2014 Prous Science, S.A.U. or its licensors. All rights reserved.

  12. Medical treatment of radiation injuries-Current US status

    Energy Technology Data Exchange (ETDEWEB)

    Jarrett, D.G. [OSA - CBD and CDP, 3050 Defense Pentagon, Room 3C257, Washington, DC 20301-3050 (United States)], E-mail: david.jarrett@us.army.mil; Sedlak, R.G.; Dickerson, W.E. [Uniformed Services University, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603 (United States); Reeves, G.I. [Northrop Grumman IT, 8211 Terminal Road, Lorton, VA 22079-1421 (United States)

    2007-07-15

    A nuclear incident or major release of radioactive materials likely would result in vast numbers of patients, many of whom would require novel therapy. Fortunately, the numbers of radiation victims in the United States (USA) have been limited to date. If a mass-casualty situation occurs, there will be a need to perform rapid, accurate dose estimates and to provide appropriate medications and other treatment to ameliorate radiation injury. The medical management of radiation injury is complex. Radiation injury may include acute radiation sickness (ARS) from external and/or internal radiation exposure, internal organ damage from incorporated radioactive isotopes, and cutaneous injury. Human and animal data have shown that optimal medical care may nearly double the survivable dose of ionizing radiation. Current treatment strategies for radiation injuries are discussed with concentration on the medical management of the hematopoietic syndrome. In addition, priority areas for continuing and future research into both acute deterministic injuries and also long-term stochastic sequelae of radiation exposure have been identified. There are several near-term novel therapies that appear to offer excellent prognosis for radiation casualties, and these are also described.

  13. Current status of radioiodine (131I) treatment of hyperthyroidism

    International Nuclear Information System (INIS)

    Becker, D.V.; Hurley, J.R.

    1982-01-01

    Radioiodine appears to be increasingly selected as the primary form of therapy for most hyperthyroid adults. Some controversy exists concerning the use of I-131 in children and adolescents as well as in some patients with toxic nodular goiter. The technical aspects of radioiodine administration reviewed in this chapter include the biologic basis of I-131 use, dose strategies, measurement and evaluation of radioiodine parameters, and I-125 treatment of hyperthyroidism. The management of patients before and after I-131 treatment is discussed as well as posttreatment hypothyroidism and complications of radioiodine treatment

  14. Current status of gastroesophageal reflux disease : diagnosis and treatment.

    Science.gov (United States)

    Chuang, Tang-Wei; Chen, Shou-Chien; Chen, Kow-Tong

    2017-01-01

    The aim of this study was to explore the recent advances in diagnosis and treatment of gastroesophageal reflux disease (GERD). Previous studies were searched using the terms "gastroesophageal reflux disease" and "diagnosis" or "treatment" in Medline and Pubmed. Articles that were not published in the English language, manuscripts without an abstract, reviews, meta-analysis, and opinion articles were excluded from the review. After a preliminary screening, all of the articles were reviewed and synthesized to provide an overview of the contemporary approaches to GERD. GERD has a variety of symptomatic manifestations, which can be grouped into typical, atypical and extra-esophageal symptoms. Those with the highest specificity for GERD are acid regurgitation and heartburn. In the absence of other alarming symptoms, these symptoms allow one to make a presumptive diagnosis of GERD and initiate empiric therapy. GERD-associated complications include erosive esophagitis, peptic stricture, Barrett's esophagus, esophageal adenocarcinoma and pulmonary disease. Management of GERD may involve lifestyle modifications, medical and surgical therapy. Medical therapy involves acid suppression, which can be achieved with antacids, histamine-receptor antagonists or proton-pump inhibitors. Whereas most patients can be effectively managed with medical therapy, others may go on to require anti-reflux surgery after undergoing a proper pre-operative evaluation. The management of this disease requires a complex approach. Maintenance therapy of GERD after using anti-secretory drugs should be continuously monitored. © Acta Gastro-Enterologica Belgica.

  15. Treatment of sepsis: current status of clinical immunotherapy.

    LENUS (Irish Health Repository)

    O'Callaghan, A

    2012-02-03

    While antibiotics address the root cause of sepsis--that of pathogen infection--they fail to provide an adequate cure for the condition. Currently, 30% to 50% of septic patients die, and this figure is likely to increase in line with the proliferation of multi-drug resistant bacteria. With an increased understanding of the immune response, it has been proposed that modulation of this defence mechanism offers the best hope of cure. Many entry-points in the immune system have been identified and targeted therapies have been developed,but why are these not in routine clinical practice? This review examines the latest evidence for the use of immuno-modulating drugs, obtained from human clinical trials. We discuss cytokine-based therapies, steroids and anti-coagulants. Finally, consideration is given as to why successful therapies in the laboratory, and in vivo models, do not automatically translate into clinical benefit

  16. Municipal wastewater treatment in Mexico: current status and opportunities for employing ecological treatment systems.

    Science.gov (United States)

    Zurita, Florentina; Roy, Eric D; White, John R

    2012-06-01

    The aim of this paper is to evaluate the current status of municipal wastewater (MWW) treatment in Mexico, as well as to assess opportunities for using ecological treatment systems, such as constructed wetlands. In 2008, Mexico had 2101 MWW treatment plants that treated only 84 m3/s of wastewater (208 m3/s ofMWW were collected in sewer systems). Unfortunately, most treatment plants operate below capacity owing to a lack of maintenance and paucity of properly trained personnel. The main types of treatment systems applied in Mexico are activated sludge and waste stabilization ponds, which treat 44.3% and 18% of the MWW collected, respectively. As in many other developing nations around the world, there is a great need in Mexico for low-cost, low-maintenance wastewater treatment systems that are both economically and environmentally sustainable. In 2005, 24.3 million Mexicans lived in villages of less than 2500 inhabitants and 14.1 million lived in towns with 2500-15,000 inhabitants. An opportunity exists to extend the use of ecological treatment systems to these low population density areas and considerably increase the percentage of MWW that is treated in Mexico. Small-scale and medium-size constructed wetlands have been built successfully in some states, primarily during the past five years. Several barriers need to be overcome to increase the adoption and utilization of ecological wastewater technology in Mexico, including: a lack of knowledge about this technology, scarce technical information in Spanish, and the government's concentration on constructing MWW treatment plants solely in urban areas.

  17. Current status of electron beam treatment of flue gas in China

    International Nuclear Information System (INIS)

    Wang Zhiguang

    2006-01-01

    Fossil resource especially coal will remain the main energy resource in China over the next 3 ∼4 decades. Pollution of flue gas from fossil power station is one problem being desiderated to solve since 1990's. Electron beam treatment of flue gas as an advanced technique has been developed and used by some institutes and industries in China. The current status of flue gas treatment using electron beam and the development of electron accelerator in China are reviewed. (author)

  18. Storage and treatment of SNF of Alfa class nuclear submarines: current status and problems

    International Nuclear Information System (INIS)

    Ignatiev, Sviatoslav; Zabudko, Alexey; Pankratov, Dmitry; Somov, Ivan; Suvorov, Gennady

    2007-01-01

    Available in abstract form only. Full text of publication follows: The current status and main problems associated with storage, defueling and following treatment of spent nuclear fuel (SNF) of Nuclear Submarines (NS) with heavy liquid metal cooled reactors are considered. In the final analysis these solutions could be realized in the form of separate projects to be funded through national and bi- and multilateral funding in the framework of the international collaboration of the Russian Federation on complex utilization of NS and rehabilitation of contaminated objects allocated in the North-West region of Russia. (authors)

  19. Current status, questions and challenges of transcatheter uterine artery embolization for the treatment of uterine fibroids

    International Nuclear Information System (INIS)

    Chen Xiaoming; Luo Pengfei

    2006-01-01

    Current status, questions and challenges of transcatheter uterine artery embolization (UAE) in the treatment of uterine fibroids were summarized and analysed. It has been proved that UAE presents a good effectiveness in controlling the symptoms and shrinkage of fibroid and uterine volumes during follow-up of 4 to 6.9 years domestically and abroad, but relapse of the fibroid may however occur in 2 years or longer after UAE. Generally speaking, UAE is safe in the treatment of uterine fibroids but has a possibility of serious complications. UAE has no damage on normal uterine tissues but may affect pregnancy and delivery of patients significantly later on the cause of hypoxia and inertia of uterus. UAE may cause amenorrhea in the minority of women with ovarian failure and endometrium atrophy. The current questions are how to improve long-term efficiency to reduce relapse of tumor and to insure the safety of UAE. It is our further task to exploit more new effective and safe embolic agents by using animal and clinical study on the basic knowledge of pathology, pharmacology, biochemistry, endocrinology and molecular biology. (authors)

  20. A review of treatment strategies for hydrofluoric acid burns: current status and future prospects.

    Science.gov (United States)

    Wang, Xingang; Zhang, Yuanhai; Ni, Liangfang; You, Chuangang; Ye, Chunjiang; Jiang, Ruiming; Liu, Liping; Liu, Jia; Han, Chunmao

    2014-12-01

    Hydrofluoric acid (HF), a dangerous inorganic acid, can cause severe corrosive effects and systemic toxicity. HF enters the human body via where it contacts, such as skin and mucosa, alimentary and respiratory tracts, and ocular surfaces. In the recent years, the incidence of HF burn has tended to increase over time. The injury mechanism of HF is associated primarily with the massive absorption of HF and the release of hydrogen ions. Correct diagnosis and timely treatment are especially important for HF burns. The critical procedure to treat HF burn is to prevent on-going HF absorption, and block the progressive destruction caused by fluoride ions. Due to the distinct characteristics of HF burns, the topical treatment, as well as systemic support, has been emphasised. Whereas, management of patients with HF burns remains a great challenge in some situations. To date, there has been no widely accepted protocol for the rescue of HF burns, partly due to the diversity of HF burns. This paper overviews the current status and problems of treatment strategies for HF burns, for the purpose of promoting the future researches and improvement. Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.

  1. Current status of presurgical infant orthopaedic treatment for cleft lip and palate patients: A critical review

    Directory of Open Access Journals (Sweden)

    P Priyanka Niranjane

    2014-01-01

    Full Text Available Rehabilitation of cleft lip and palate (CLP patients is a challenge for all the concerned members of the cleft team, and various treatment modalities have been attempted to obtain aesthetic results. Presurgical infant orthopaedics (PSIO was introduced to reshape alveolar and nasal segments prior to surgical repair of cleft lip. However, literature reports lot of controversy regarding the use of PSIO in patients with CLP. Evaluation of long-term results of PSIO can provide scientific evidence on the efficacy and usefulness of PSIO in CLP patients. The aim was to assess the scientific evidence on the efficiency of PSIO appliances in patients with CLP and to critically analyse the current status of PSIO. A PubMed search was performed using the terms PSIO, presurgical nasoalveolar moulding and its long-term results and related articles were selected for the review. The documented studies report no beneficial effect of PSIO on maxillary arch dimensions, facial aesthetics and in the subsequent development of dentition and occlusion in CLP patients. Nasal moulding seems to be more beneficial and effective in unilateral cleft lip and palate patients with better long-term results.

  2. The development and current status of 131I treatment for hyperthyroidism

    International Nuclear Information System (INIS)

    Wang Chunmei; Wang Xuemei

    2010-01-01

    Hyperthyroidism is an autoimmune diseasein which excessive amounts of thyroid hormones circulate in the blood. The treatments for hyperthyroidism mainly include antithyroid drugs, 131 I treatment, and surgery. 131 I had been verified as an effective, safe, simple method to treat adult and children hyperthyroidism. Current research trends of 131 I treatment mainly are problems of 131 I treatment of hyperthyroidism and its long-term security. (authors)

  3. Current status of epilepsy treatment and efficacy of standard phenobarbital therapy in rural areas of Northern China.

    Science.gov (United States)

    Yu, Jinbei; Luo, Nan; Wang, Zan; Lin, Weihong

    2017-08-01

    To investigate the current status of epilepsy treatment and the efficacy and adverse effects of phenobarbital therapy in rural areas of Northern China. A total of 2192 patients diagnosed with convulsive epilepsy were recruited from seven different rural regions in Jilin Province, China to investigate the current status of epilepsy treatment, and 1379 of them were enrolled in a standard phenobarbital therapy trial. Patients were selected according to strict inclusion and exclusion criteria, and medical records for all patients were collected and analyzed before the standard treatment was started. Patients were followed up monthly, and efficacy in 1218 patients was analyzed at 1, 3, 6 and 12 months of treatment. More patients had the initial seizure in juveniles than in adults, and 40.72% of the 2192 patients were not receiving any treatment before the treatment trial. The efficacy of phenobarbital increased and adverse effects decreased within the treatment period. Among the 349 patients who were followed up for 12 months from the beginning of the phenobarbital treatment, seizures were decreased by more than 75% in 71.3% of patients using a low-to-medium dose of phenobarbital. Major adverse effects of phenobarbital included mild exhaustion, drowsiness, dizziness and headache. Standardized long-term and regular administration of phenobarbital at a low-to-medium dose can be used as an effective, economic and safe treatment against epilepsy in rural areas.

  4. Teleradiology - current status

    International Nuclear Information System (INIS)

    Baltadjiev, D.; Charakchiev

    2000-01-01

    Tele-radiology is a term becoming increasingly popular in the medical literature. Nevertheless, terminological definitions in this particular field are still rather vague. The scope of applications extend from simple image presenting via analogue telephone lines to transmission of 3-D medical images through a satellite. It is a matter of standards highly differing in terms of data transmission rates, safety, technical demands on the systems and the like. In this article new information technologies, technical aspects, as well as some major applications of tele-radiology are discussed. The current status of tele-medicine/tele-radiology in this country is likewise briefly outlined

  5. Biotechnological Utilization with a Focus on Anaerobic Treatment of Cheese Whey: Current Status and Prospects

    Directory of Open Access Journals (Sweden)

    Aspasia A. Chatzipaschali

    2012-09-01

    Full Text Available Cheese whey utilization is of major concern nowadays. Its high organic matter content, in combination with the high volumes produced and limited treatment options make cheese whey a serious environmental problem. However, the potential production of biogas (methane, hydrogen or other marketable products with a simultaneous high COD reduction through appropriate treatment proves that cheese whey must be considered as an energy resource rather than a pollutant. The presence of biodegradable components in the cheese whey coupled with the advantages of anaerobic digestion processes over other treatment methods makes anaerobic digestion an attractive and suitable treatment option. This paper intends to review the most representative applications of anaerobic treatment of cheese whey currently being exploited and under research. Moreover, an effort has been made to categorize the common characteristics of the various research efforts and find a comparative basis, as far as their results are concerned. In addition, a number of dairy industries already using such anaerobic digestion systems are presented.

  6. [Current status and expectations in the surgical treatment of recurrent lateral patellar dislocation].

    Science.gov (United States)

    Zhao, Zhi-Dong; Li, Peng-Cui; Wei, Xiao-Chun

    2017-11-25

    Up to now, surgical treatment of recurrent lateral patellar dislocation mainly includes: medial patellofemoral ligament reconstruction, tibial tubercle osteotomy, trochleoplasty, lateral retinacular release, derotation osteotomy and so on . Clinical reports show that: the use of a single or combined with several methods have achieved ideal short to mid-term clinical outcomes. However, there is no consolidate criterion concerning the choices of different kinds of surgical ways for the treatment of individual recurrent lateral patellar dislocation. Meanwhile, with the wide use of MPFL reconstruction and other surgical options, there are more and more complications and failures that are worthy and necessary for us to pay attention to, even though its high success rate. The aim of this article is to make a systematic review of the application status of different surgical methods, collecting the positive results we have achieved, illuminating application keys of surgical techniques, guiding patient-specific therapy more precisely. Copyright© 2017 by the China Journal of Orthopaedics and Traumatology Press.

  7. Substance Use in Rural Central Appalachia: Current Status and Treatment Considerations.

    Science.gov (United States)

    Moody, Lara; Satterwhite, Emily; Bickel, Warren K

    2017-04-01

    The burden of substance use and especially the unmatched rates of overdoses in rural Central Appalachia highlight the need for innovative approaches to curb the initiation to drug misuse and to address current substance use disorders. Effective substance use interventions involve a thorough understanding of the region. In Central Appalachia, many of the barriers to treatment are shared with other rural and impoverished areas, including a lack of access to health care and lack of health care providers with specialized training. Parts of Appalachia also present their own considerations, including the challenges of fostering trust and encouraging treatment-seeking in communities with dense, long-term, place-based social and family networks. Current policies and interventions for substance use have been largely inadequate in the region, as evidenced by continued increases in substance use and substance-related deaths, especially related to nonmedical prescription drug use and increasing heroin use. The authors discuss ways in which rural life, poverty, identity, and values in Appalachia have influenced substance use and treatment and propose strategies and interventions to improve outcomes.

  8. COHERENT Experiment: current status

    International Nuclear Information System (INIS)

    Akimov, D; Belov, V; Bolozdynya, A; Burenkov, A; Albert, J B; Del Valle Coello, M; D’Onofrio, M; Awe, C; Barbeau, P S; Cervantes, M; Becker, B; Cabrera-Palmer, B; Collar, J I; Cooper, R J; Cooper, R L; Cuesta, C; Detwiler, J; Eberhardt, A; Dean, D; Dolgolenko, A G

    2017-01-01

    The COHERENT Collaboration is realizing a long term neutrino physics research program. The main goals of the program are to detect and study elastic neutrino-nucleus scattering (CEνNS). This process is predicted by Standard Model but it has never been observed experimentally because of the very low energy of the recoil nucleus. COHERENT is using different detector technologies: CsI[Na] and NaI scintillator crystals, a single-phase liquid Ar and a Ge detectors. The placement of all the detector setups is in the basement of the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory (ORNL). The current status of the COHERENT experimental program is presented. (paper)

  9. Combining Pharmacological and Psychological Treatments for Binge Eating Disorder: Current Status, Limitations, and Future Directions.

    Science.gov (United States)

    Grilo, Carlos M; Reas, Deborah L; Mitchell, James E

    2016-06-01

    Binge eating disorder (BED) is characterized by recurrent binge eating and marked distress about binge eating without the extreme compensatory behaviors for weight control that characterize other eating disorders. BED is prevalent, associated strongly with obesity, and is associated with heightened levels of psychological, psychiatric, and medical concerns. This article provides an overview of randomized controlled treatments for combined psychological and pharmacological treatment of BED to inform current clinical practice and future treatment research. In contrast to the prevalence and significance of BED, to date, limited research has been performed on combining psychological and pharmacological treatments for BED to enhance outcomes. Our review here found that combining certain medications with cognitive behavioral therapy (CBT) or behavioral weight loss (BWL) interventions produces superior outcomes to pharmacotherapy only but does not substantially improve outcomes achieved with CBT/BWL only. One medication (orlistat) has improved weight losses with CBT/BWL albeit minimally, and only one medication (topiramate) has enhanced reductions achieved with CBT in both binge eating and weight. Implications for future research are discussed.

  10. Current status of laparoendoscopic rendezvous in the treatment of cholelithiasis with concomitant choledocholithiasis.

    Science.gov (United States)

    Baloyiannis, Ioannis; Tzovaras, George

    2015-06-25

    The current evidence in favor of the laparoendoscopic rendezvous is promising and demonstrates the main advantages of this technique in regard to shorter hospital stay and selective cannulation of the common bile duct (CBD), avoiding thus the inadvertent cannulation of the pancreatic duct. In addition, in the rendezvous technique the contrast medium is not injected retrogradely as during the traditional endoscopic retrograde cholangiopancreatography (ERCP), when the medium accidentally could be injected under pressure into the pancreatic duct. The RV technique minimizes that risk. Both these main advantages of the RV technique over the classic ERCP, are related with a significant lower incidence of hyperamylasemia and post-ERCP pancreatitis, compared with the traditional two stage procedure. Choledocholithiasis is present in 10% to 15% of patients undergoing cholecystectomy. To date, the ideal management of CBD stones remains controversial. Prospective randomized trials have shown that laparoscopic management of the CBD stones, as a single stage procedure, is the most efficient and cost effective method of treatment. Laparoendoscopic rendezvous has been proposed as an alternative single stage approach. Several studies have shown the effective use of this technique in the treatment of CBD stones by improving patient compliance and clinical results including shorter hospital stay, higher success rate and less cost. The current evidence about the use of this technique presented in this review article is promising and demonstrates the main advantages of the procedure.

  11. Therapeutic Potential of Curcumin in Treatment of Pancreatic Cancer: Current Status and Future Perspectives.

    Science.gov (United States)

    Hosseini, Mina; Hassanian, Seyed Mahdi; Mohammadzadeh, Elham; ShahidSales, Soodabeh; Maftouh, Mina; Fayazbakhsh, Hasan; Khazaei, Majid; Avan, Amir

    2017-07-01

    Pancreatic cancer is among the leading cause of deaths due to cancer with extremely poor prognosis. Gemcitabine is being used in the treatment of patient with pancreatic ductal adenocarcinoma (PDAC), although, the response rate is bellow 12%. A recent phase III trial revealed that FOLFIRINOX could be an option for the treatment of metastatic PDAC patients, although it is associated with increased toxicity. Therefore, identification of novel agents that either improves gemcitabine activity, within novel combinatorial approaches, or with a better efficacy than gemcitabine is warranted. The antitumor activity of curcumin in several tumors, including prostate, breast and colorectal cancers have investigated. A recent phase II trial explored the effects of curcumin in advanced pancreatic cancer patient. They found that oral curcumin was well tolerated. Another trial showed the activity of 8,000 mg of curcumin in combination with gemcitabine in patients with advanced pancreatic cancer. This review summarizes the current knowledge about possible molecular mechanisms of curcumin in PDAC with particular emphasis on preclinical/clinical studies in pancreatic cancer treatment. J. Cell. Biochem. 118: 1634-1638, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  12. The radiological diagnosis and treatment of renal angiomyolipoma-current status.

    LENUS (Irish Health Repository)

    Halpenny, D

    2010-02-01

    Angiomyolipomas (AMLs) are the most common benign renal neoplasm and are often discovered incidentally. Due to both an increase in the use of imaging, as well as advances in imaging technology, they are being increasing identified in the general population. As these lesions are benign, there is good evidence that the majority of them can be safely followed up without treatment. However, there is an increasing wealth of information available suggesting there are individuals with AMLs where prophylactic treatment is indicated to prevent complications such as haemorrhage. In such cases, treatment with radiological interventional techniques with subselective particle embolization has superseded surgical techniques in most cases. Even in emergency cases with catastrophic rupture, prompt embolization may save the patient with the additional benefit of renal salvage. Confident identification of a lesion as an AML is important as its benign nature obviates the need for surgery in most cases. The presence of fat is paramount in the confirmatory identification and characterization of these lesions. Although fat-rich AMLs are easy to diagnose, some lesions are fat poor and it is these cases where newer imaging techniques, such as in-phase and out-of-phase magnetic resonance imaging (MRI) may aid in making a confident diagnosis of AML. In this paper, we comprehensively review the imaging techniques in making a diagnosis of AML, including features of both characteristic lesions as well as atypical lesions. In addition, we discuss current guidelines for follow-up and prophylactic treatment of these lesions, as well as the increasing role that the interventional radiologist has to play in these cases.

  13. The role of stents in the treatment of congenital heart disease: Current status and future perspectives

    International Nuclear Information System (INIS)

    Peters, Bjoern; Ewert, Peter; Berger, Felix

    2009-01-01

    Intravascular or intracardiac stenoses occur in many forms of congenital heart disease (CHD). Therefore, the implantation of stents has become an accepted interventional procedure for stenotic lesions in pediatric cardiology. Furthermore, stents are know to be used to exclude vessel aneurysm or to ensure patency of existing or newly created intracardiac communications. With the further refinement of the first generation of devices, a variety of “modern” stents with different design characteristics have evolved. Despite the tremendous technical improvement over the last 20 years, the “ideal stent” has not yet been developed. Therefore, the pediatric interventionalist has to decide which stent is suitable for each lesion. On this basis, currently available stents are discussed in regard to their advantages and disadvantages for common application in CHD. New concepts and designs developed to overcome some of the existing problems, like the failure of adaptation to somatic growth, are presented. Thus, in the future, biodegradable or growth stents might replace the currently used generation of stents. This might truly lead to widening indications for the use of stents in the treatment of CHD

  14. Current status of prophylactic surgical treatment for familial adenomatous polyposis in Japan.

    Science.gov (United States)

    Yamadera, Masato; Ueno, Hideki; Kobayashi, Hirotoshi; Konishi, Tsuyoshi; Ishida, Fumio; Yamaguchi, Tatsuro; Hinoi, Takao; Inoue, Yasuhiro; Kanemitsu, Yukihide; Tomita, Naohiro; Ishida, Hideyuki; Sugihara, Kenichi

    2017-06-01

    We conducted this study to clarify the current clinical practice of prophylactic colectomy for patients with familial adenomatous polyposis (FAP) in Japan. This retrospective multi-center cohort study involved 23 specialized institutions for colorectal disease in Japan. We analyzed the records of 147 patients who underwent prophylactic surgical treatment between 2000 and 2012. Patients were divided into Group 1 (2000-2006) and Group 2 (2007-2012) based on their date of surgery. Age at the time of prophylactic surgery was 27 and 31 years in Groups 1 and 2, respectively. The proportion of attenuated FAP was significantly lower in Group 2 than in Group 1 (1.0 vs. 13 %, respectively). Pathological examination revealed an increased incidence of malignant polyps in the resected specimens from Group 2 patients (10 vs. 23 %, respectively; P = 0.034). Laparoscopic surgery was more frequent in Group 2 than in Group 1 (61 vs. 40 %, respectively). There was no surgical mortality in either group. Prophylactic surgery for FAP results in good short-term surgical outcomes in Japan. The current surgical approach is characterized by limited surgical indications for patients with attenuated FAP, delayed timing of colectomy, and the increasing standardization of laparoscopic surgery.

  15. Current status of achalasia management: a review on diagnosis and treatment.

    Science.gov (United States)

    Tuason, Joshua; Inoue, Haruhiro

    2017-04-01

    Achalasia is a rare esophageal motility disorder that is characterized by loss of peristalsis and failure of relaxation of the lower esophageal sphincter (LES), particularly during swallowing. This review focuses on the diagnosis of esophageal motility disorders as defined by the Chicago Classification ver 3.0, and presents management options with regard to per-oral endoscopic myotomy (POEM) as the treatment of choice. A concise review of literature was performed for articles related to the management of achalasia, and this was contrasted with our institution's current practice. Achalasia is still incompletely understood, and management is focused on establishing a proper diagnosis, and relieving the obstructive symptoms. Achalasia should be considered when dysphagia is present, and not otherwise caused by an obstruction or inflammation, and when criteria is met as per the Chicago Classification ver 3.0. Lowering LES tone and disruption of LES can be accomplished by various methods, most notably pneumatic balloon dilatation and surgical myotomy. POEM has been gaining momentum as a first line therapy for achalasia symptoms, and can be considered an important tool for motility disorders of the esophagus.

  16. [Current status and future prospect of internal medicine treatment for advanced esophageal cancer].

    Science.gov (United States)

    Wang, F; Fan, Q X

    2016-09-23

    Esophageal cancer (EC) is one of common malignant tumors, and the incidence and mortality of EC in China rank the first place in the world. Because of the occult onset, the early atypical symptoms, and the lack of effective early diagnostic methods, most of patients are diagnosed at an advanced stage of the disease and lost the chance of surgery. Comprehensive treatment including palliative medical treatment, molecular targeted therapy, immunotherapy and so on is appropriate for these patients. How to choose the chemotherapy regimen and formulate reasonable treatment plan has become a hot spot in clinical research. Molecular targeted drugs have become a new developmental direction in cancer treatment because of their high specificity and antitumor activity, but the effects on esophageal cancer remain controversial. With the development of immune check point blockade treatment, breakthrough has been made in tumor immunotherapy, which has become an important means in cancer comprehensive treatment and shown a good prospect of treatment.

  17. Current Status of HPV Vaccines

    Science.gov (United States)

    Ma, Barbara; Roden, Richard; Wu, T.C.

    2010-01-01

    Cervical cancer is the second largest cause of cancer deaths in women worldwide, with ~500,000 diagnoses and 274,000 deaths annually. It remains a significant source of morbidity and mortality despite effective screening tools and treatments for its precursor high-grade cervical intraepithelial neoplasia (CIN). Increased understanding of cervical pathogenesis has led to the identification of human papillomavirus (HPV) as the etiological agent for cervical cancer and the development of preventive and therapeutic vaccines targeting HPV antigens for the control of cervical cancer. Herein, we discuss the current status of HPV vaccines. PMID:20677402

  18. Interventional Treatment of Abdominal Compartment Syndrome during Severe Acute Pancreatitis: Current Status and Historical Perspective

    Directory of Open Access Journals (Sweden)

    Dejan V. Radenkovic

    2016-01-01

    Full Text Available Abdominal compartment syndrome (ACS in patients with severe acute pancreatitis (SAP is a marker of severe disease. It occurs as combination of inflammation of retroperitoneum, visceral edema, ascites, acute peripancreatic fluid collections, paralytic ileus, and aggressive fluid resuscitation. The frequency of ACS in SAP may be rising due to more aggressive fluid resuscitation, a trend towards conservative treatment, and attempts to use a minimally invasive approach. There remains uncertainty about the most appropriate surgical technique for the treatment of ACS in SAP. Some unresolved questions remain including medical treatment, indications, timing, and interventional techniques. This review will focus on interventional treatment of this serious condition. First line therapy is conservative treatment aiming to decrease IAP and to restore organ dysfunction. If nonoperative measures are not effective, early abdominal decompression is mandatory. Midline laparostomy seems to be method of choice. Since it carries significant morbidity we need randomized studies to establish firm advantages over other described techniques. After ACS resolves efforts should be made to achieve early primary fascia closure. Additional data are necessary to resolve uncertainties regarding ideal timing and indication for operative treatment.

  19. Interventional Treatment of Abdominal Compartment Syndrome during Severe Acute Pancreatitis: Current Status and Historical Perspective.

    Science.gov (United States)

    Radenkovic, Dejan V; Johnson, Colin D; Milic, Natasa; Gregoric, Pavle; Ivancevic, Nenad; Bezmarevic, Mihailo; Bilanovic, Dragoljub; Cijan, Vladimir; Antic, Andrija; Bajec, Djordje

    2016-01-01

    Abdominal compartment syndrome (ACS) in patients with severe acute pancreatitis (SAP) is a marker of severe disease. It occurs as combination of inflammation of retroperitoneum, visceral edema, ascites, acute peripancreatic fluid collections, paralytic ileus, and aggressive fluid resuscitation. The frequency of ACS in SAP may be rising due to more aggressive fluid resuscitation, a trend towards conservative treatment, and attempts to use a minimally invasive approach. There remains uncertainty about the most appropriate surgical technique for the treatment of ACS in SAP. Some unresolved questions remain including medical treatment, indications, timing, and interventional techniques. This review will focus on interventional treatment of this serious condition. First line therapy is conservative treatment aiming to decrease IAP and to restore organ dysfunction. If nonoperative measures are not effective, early abdominal decompression is mandatory. Midline laparostomy seems to be method of choice. Since it carries significant morbidity we need randomized studies to establish firm advantages over other described techniques. After ACS resolves efforts should be made to achieve early primary fascia closure. Additional data are necessary to resolve uncertainties regarding ideal timing and indication for operative treatment.

  20. The Transjugular Intrahepatic Portosystemic Shunt in the Treatment of Portal Hypertension: Current Status

    Directory of Open Access Journals (Sweden)

    Gilles Pomier-Layrargues

    2012-01-01

    Full Text Available The transjugular intrahepatic portosystemic shunt (TIPS represents a major advance in the treatment of complications of portal hypertension. Technical improvements and increased experience over the past 24 years led to improved clinical results and a better definition of the indications for TIPS. Randomized clinical trials indicate that the TIPS procedure is not a first-line therapy for variceal bleeding, but can be used when medical treatment fails, both in the acute situation or to prevent variceal rebleeding. The role of TIPS to treat refractory ascites is probably more justified to improve the quality of life rather than to improve survival, except for patients with preserved liver function. It can be helpful for hepatic hydrothorax and can reverse hepatorenal syndrome in selected cases. It is a good treatment for Budd Chiari syndrome uncontrollable by medical treatment. Careful selection of patients is mandatory before TIPS, and clinical followup is essential to detect and treat complications that may result from TIPS stenosis (which can be prevented by using covered stents and chronic encephalopathy (which may in severe cases justify reduction or occlusion of the shunt. A multidisciplinary approach, including the resources for liver transplantation, is always required to treat these patients.

  1. Molecular basis of hepatic fibrosis and current status of its diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    LI Yan

    2018-01-01

    Full Text Available During the process of acute or chronic liver injury, hepatic stellate cells interact with various types of cells such as hepatic parenchymal cells, Kupffer cells, and liver sinusoidal endothelial cells to mediate extracellular matrix deposition and sinusoid capillarization and thus initiate the process of hepatic fibrosis. The nature of hepatic fibrosis is repair response after liver injury. Liver biopsy is regarded as the gold standard for the diagnosis of hepatic fibrosis; however, it is generally associated with the risk of bleeding and even death. Noninvasive diagnostic methods for liver fibrosis mainly include serum biomarkers, imaging techniques, and predictive statistical model, but such methods cannot completely replace liver biopsy. At present, the treatment of hepatic fibrosis focuses on the research and development of new drugs targeting primary disease, hepatic stellate cells, or balance of extracellular matrix synthesis/degradation. The research on the molecular mechanism of hepatic fibrosis provides a solid theoretical basis for exploring the treatment of hepatic fibrosis.

  2. N-acetylcysteine in the treatment of psychiatric disorders: current status and future prospects.

    Science.gov (United States)

    Minarini, Alessandro; Ferrari, Silvia; Galletti, Martina; Giambalvo, Nina; Perrone, Daniela; Rioli, Giulia; Galeazzi, Gian Maria

    2017-03-01

    N-acetylcysteine (NAC) is widely known for its role as a mucolytic and as an antidote to paracetamol overdose. There is increasing interest in the use of NAC in the treatment of several psychiatric disorders. The rationale for the administration of NAC in psychiatric conditions is based on its role as a precursor to the antioxidant glutathione, and its action as a modulating agent of glutamatergic, dopaminergic, neurotropic and inflammatory pathways. Areas covered: This study reviews the available data regarding the use of NAC in different psychiatric disorders including substance use disorders, autism, obsessive-compulsive spectrum disorders, schizophrenia, depression, bipolar disorder. Promising results were found in trials testing the use of NAC, mainly as an add-on treatment, in cannabis use disorder in young people, depression in bipolar disorder, negative symptoms in schizophrenia, and excoriation (skin-picking) disorder. Despite initial optimism, recent findings regarding NAC efficacy in autism have been disappointing. Expert opinion: These preliminary positive results require further confirmation in larger samples and with longer follow-ups. Given its high tolerability and wide availability, NAC represents an important target to investigate in the field of new adjunctive treatments for psychiatric conditions.

  3. Idiopathic pulmonary fibrosis: current understanding of the pathogenesis and the status of treatment.

    Science.gov (United States)

    Khalil, Nasreen; O'Connor, Robert

    2004-07-20

    Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal pulmonary fibrotic lung disease. The diagnostic histological changes are called usual interstitial pneumonia and are characterized by histological temporal heterogeneity, whereby normal lung tissue is interspersed with interstitial fibrosis, honeycomb cysts and fibroblast foci. Pulmonary functions show restricted volumes and capacities, preserved flows and evidence of decreased gas exchange. High-resolution computed axial tomography demonstrates evidence of fibrosis and lung remodelling such as honeycomb cysts and traction bronchiectasis. There is no known effective treatment for IPF, but lung transplantation improves survival.

  4. Evolution of checkpoint inhibitors for the treatment of metastatic gastric cancers: Current status and future perspectives.

    Science.gov (United States)

    Taieb, Julien; Moehler, Markus; Boku, Narikazu; Ajani, Jaffer A; Yañez Ruiz, Eduardo; Ryu, Min-Hee; Guenther, Silke; Chand, Vikram; Bang, Yung-Jue

    2018-05-01

    Standard treatment options for patients with advanced gastric or gastroesophageal junction cancer (GC/GEJC) are associated with limited efficacy and some toxicity. Recently, immunotherapy with antibodies that inhibit the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) interaction has emerged as a new treatment option. This manuscript reviews early-phase and late-phase trials of immunotherapy in advanced GC/GEJC. Searches for studies of immunotherapy in GC/GEJC were performed using PubMed, ClinicalTrials.gov, and abstract databases for select annual congresses. Findings were interpreted based on expert opinion. Monotherapy with anti-PD-1/PD-L1 antibodies, including pembrolizumab, nivolumab, avelumab, durvalumab, and atezolizumab, has shown interesting objective response rates (ORRs; 7-26%) across varying GC/GEJC populations, with ORRs potentially higher in PD-L1 + vs PD-L1 - tumors. Safety profiles compare favorably with chemotherapy, with grade ≥3 treatment-related adverse events occurring in 5-17%. Based on a large phase 2 study, pembrolizumab was approved in the United States for third-line treatment of patients with PD-L1 + GC/GEJC. In a phase 3 trial, third-line or later nivolumab increased overall survival vs placebo in an Asian population, leading to regulatory approval in Japan, although other completed phase 3 trials did not show superiority for pembrolizumab or avelumab monotherapy vs chemotherapy. Other trials in advanced GC/GEJC are assessing various anti-PD-1/PD-L1-based strategies, including administration in first-line and later-line settings and as combination (with chemotherapy or agents targeting other immune checkpoint proteins, eg, CTLA-4, LAG-3, and IDO) or switch-maintenance regimens. Anti-PD-1/PD-L1 antibodies have shown encouraging clinical activity in advanced GC/GEJC. Results from ongoing phase 3 trials are needed to further evaluate the potential roles of these agents within the continuum of care. Copyright

  5. New treatment directions for IPF: current status of ongoing and upcoming clinical trials.

    Science.gov (United States)

    Macagno, Francesco; Varone, Francesco; Leone, Paolo Maria; Mari, Pier-Valerio; Panico, Loredana; Berardini, Ludovica; Richeldi, Luca

    2017-07-01

    The main objective of this review is to explore the wide and expanding field of new clinical trials in IPF. Recent trials have confirmed the efficacy of the approved drugs pirfenidone and nintedanib; nonetheless, the discovery of new biological pathways has opened new horizons in this field. Areas covered: New strategies against matrix deposition are under study and so is for the role of immunity and autoimmunity. Recent advances in the use of stem cells are opening new possibilities for the recovery of damaged lung tissues. The role of microbioma is under investigation in order to evaluate the use of antibiotics in IPF treatment. Analysing all the new and the upcoming clinical trials, we are trying to offer a comprehensive view of the emerging new frontiers in the treatment of IPF. Expert commentary: The key points for the ongoing and upcoming clinical trials will be to avoid previous mistakes and to choose carefully both study populations and efficacy endpoints. The exciting possibility to enrol patients with progressive lung fibrosis, both idiopathic and not, could be a next step forward. How the existing therapies will fit in a futurist scenario of personalized medicine is still a challenge.

  6. Targeted Therapy of FLT3 in Treatment of AML—Current Status and Future Directions

    Directory of Open Access Journals (Sweden)

    Caroline Benedicte Nitter Engen

    2014-12-01

    Full Text Available Internal tandem duplications (ITDs of the gene encoding the Fms-Like Tyrosine kinase-3 (FLT3 receptor are present in approximately 25% of patients with acute myeloid leukemia (AML. The mutation is associated with poor prognosis, and the aberrant protein product has been hypothesized as an attractive therapeutic target. Various tyrosine kinase inhibitors (TKIs have been developed targeting FLT3, but in spite of initial optimism the first generation TKIs tested in clinical studies generally induce only partial and transient hematological responses. The limited treatment efficacy generally observed may be explained by numerous factors; extensively pretreated and high risk cohorts, suboptimal pharmacodynamic and pharmacokinetic properties of the compounds, acquired TKI resistance, or the possible fact that inhibition of mutated FLT3 alone is not sufficient to avoid disease progression. The second-generation agent quizartinb is showing promising outcomes and seems better tolerated and with less toxic effects than traditional chemotherapeutic agents. Therefore, new generations of TKIs might be feasible for use in combination therapy or in a salvage setting in selected patients. Here, we sum up experiences so far, and we discuss the future outlook of targeting dysregulated FLT3 signaling in the treatment of AML.

  7. Current status of HIV treatment in Asia and the Pacific region.

    Science.gov (United States)

    Phuphuakrat, Angsana; Kiertiburanakul, Sasisopin; Sungkanuparph, Somnuek

    2014-07-01

    Asia and the Pacific represent a diverse group of nations facing HIV epidemic profiles of differing severity. Compared to other parts of the world, the burden of HIV disease is high in this region because of its large populations. At the end of 2011, 5million people were living with HIV in Asia and the Pacific. This accounted for 15% of people living with HIV worldwide. The prevalence of people living with HIV, as well as access to HIV treatment and care, varies widely between countries. Differences between high-income economies and the rest of the continent are remarkable. Many high-income countries provide antiretroviral therapy (ART) to their citizens. Middle- and low-income countries have rapid ART scale-up and are dependent on international funding. This may compromise the sustainability of ART availability. In addition, lack of access to second- and third-line therapy remains a problem in many countries. The global goal of achieving universal access to ART by 2015 requires mainly low- and middle-income countries to be targeted. Regional policy should be developed in order to identify new infections in key populations, to start earlier treatment, to retain patients in care and to maintain funding.

  8. [Current status of the prevention and treatment of stoma complications. A narrative review].

    Science.gov (United States)

    de Miguel Velasco, Mario; Jiménez Escovar, Fernando; Parajó Calvo, Alberto

    2014-03-01

    The aim of our study was to perform a review of the literature to assess the results of prevention and treatment of stoma complications. Medline, EMBASE medical database and the Cochrane Library were searched up to December 2012. Stomal complications are prevalent and associated with a worse quality of life and increased health-economic burdens. The most common complications are attributed to stoma construction. Attention to the finer technical points performed by experienced surgeons reduces morbidity. The use of mesh reduces the risk of parastomal hernia and recurrence rates in hernia repair. Preoperative stoma site marking and postoperative care by a stomatherapist are crucial for the patients' successful adaption, improving quality of life, promoting their independence and reducing the rates of complications. Copyright © 2013 AEC. Published by Elsevier Espana. All rights reserved.

  9. Current status of treatment of metastatic colorectal cancer with special reference to cetuximab and elderly patients

    Directory of Open Access Journals (Sweden)

    Per Pfeiffer

    2008-12-01

    Full Text Available Per Pfeiffer, Camilla Qvortrup, Jon K BjerregaardDepartment of Oncology, Odense University Hospital. Institute of Clinical Research, University of Southern Denmark. Odense C, DenmarkPurpose: Elderly cancer patients often have co-morbidities and other characteristics that make the selection of optimal treatment more complex. The introduction of targeted therapies in colorectal cancer has further complicated this problem. This review will focus on the role of the EGFR antibody cetuximab in elderly patients.Methods: We have reviewed the available evidence in the literature to evaluate the results of therapy with cetuximab, alone or in combination with chemotherapy, with a focus on elderly patients with metastatic colorectal cancer (mCRC.Results: In patients with mCRC, combination chemotherapy prolongs median survival to more than 18 months and even around 24 months in combination with cetuximab in selected patients. No prospective studies have evaluated cetuximab in elderly patients. However, subgroup analyses from randomized trials and retrospective analysis suggest that the efficacy of chemotherapy and cetuximab is maintained in fit elderly patients, but with slightly increased but acceptable toxicity.Conclusion: No prospective cetuximab studies have been conducted solely in a population of elderly patients. However, available data suggest that outcomes in the fit elderly mirror results observed in younger patients.Keywords: metastatic colorectal cancer, cetuximab, elderly patients

  10. Percutaneous uterine artery embolization for the treatment of symptomatic fibroids: current status

    International Nuclear Information System (INIS)

    Lupattelli, Tommaso; Basile, Antonio; Garaci, Francesco Giuseppe; Simonetti, Giovanni

    2005-01-01

    Uterine artery embolization (UAE) is increasingly being used as an alternative treatment to hysterectomy for symptomatic fibroids. Symptoms of pelvic pressure, urinary frequency and menorrhagia are controlled in 73-98% of patients who undergo UAE. At the 1-year follow-up, the uterus may shrink by up to 55% but re-growth of fibroid may however occur. The rate of major complications and amenorrhoea following this procedure is low, ranging in most series from 1 to 3.5% and 1 to 7%, respectively. Nevertheless, the rate of amenorrhoea in women over 45 seems to be higher. In order to completely block the arterial supply to the fibroid, UAE is typically performed in both uterine arteries. Different embolic agents are used such as polyvinyl alcohol, gelfoam and more recently gelatine tris-acryl microspheres. After UAE, perfusion of the uterus is maintained. Uterine function is therefore conserved and although women who become pregnant after UAE seem to be at risk for malpresentation, pre-term birth, cesarean delivery and postpartum hemorrhage, successful pregnancies after UAE have been reported in some series. A major technical problem with UAE remains the possible presence of fibroid blood supply from other sources, such as the ovarian arteries or other pelvic branches, which can lead to failure of the procedure. In conclusion, although randomized trials are still underway, UAE appears a good option for those patients who wish to conserve their fertility or when surgery is contra-indicated. However, to evaluate the long-term effects of UAE longer follow up is required

  11. Percutaneous uterine artery embolization for the treatment of symptomatic fibroids: current status

    Energy Technology Data Exchange (ETDEWEB)

    Lupattelli, Tommaso; Basile, Antonio; Garaci, Francesco Giuseppe; Simonetti, Giovanni

    2005-04-01

    Uterine artery embolization (UAE) is increasingly being used as an alternative treatment to hysterectomy for symptomatic fibroids. Symptoms of pelvic pressure, urinary frequency and menorrhagia are controlled in 73-98% of patients who undergo UAE. At the 1-year follow-up, the uterus may shrink by up to 55% but re-growth of fibroid may however occur. The rate of major complications and amenorrhoea following this procedure is low, ranging in most series from 1 to 3.5% and 1 to 7%, respectively. Nevertheless, the rate of amenorrhoea in women over 45 seems to be higher. In order to completely block the arterial supply to the fibroid, UAE is typically performed in both uterine arteries. Different embolic agents are used such as polyvinyl alcohol, gelfoam and more recently gelatine tris-acryl microspheres. After UAE, perfusion of the uterus is maintained. Uterine function is therefore conserved and although women who become pregnant after UAE seem to be at risk for malpresentation, pre-term birth, cesarean delivery and postpartum hemorrhage, successful pregnancies after UAE have been reported in some series. A major technical problem with UAE remains the possible presence of fibroid blood supply from other sources, such as the ovarian arteries or other pelvic branches, which can lead to failure of the procedure. In conclusion, although randomized trials are still underway, UAE appears a good option for those patients who wish to conserve their fertility or when surgery is contra-indicated. However, to evaluate the long-term effects of UAE longer follow up is required.

  12. Biosimilar drugs: Current status.

    Science.gov (United States)

    Kumar, Rajiv; Singh, Jagjit

    2014-07-01

    Biologic products are being developed over the past three decades. The expiry of patent protection for many biological medicines has led to the development of biosimilars in UK or follow on biologics in USA. This article reviews the literature on biosimilar drugs that covers the therapeutic status and regulatory guidelines. Appraisal of published articles from peer reviewed journals for English language publications, search from PubMed, and guidelines from European Medicines Agency, US Food Drug Administration (FDA) and India were used to identify data for review. Literature suggest that biosimilars are similar biological products, i.e., comparable but not identical to the reference product, are not generic version of innovator product and do not ensure therapeutic equivalence. Biosimilars present more challenges than conventional generics and marketing approval is also more complicated. To improve access, US Congress passed the Biologics Price Competition and Innovation act 2009 and US FDA allowed "abbreviated pathway" for their approval. U.S law has defined new standards and terms and EMA scientific guidelines have also set detailed approval standards. India being one of the most preferred manufacturing destinations of biosimilars, there is a need for stringent safety and regulatory guidelines. The New India Guidelines "Draft Guidelines on Similar Biologics were announced in June 2012, by Department of Biotechnology at Boston bio and available online.

  13. Current status of mammography

    International Nuclear Information System (INIS)

    Crymes, J.E.

    1979-01-01

    Great progress has been made in recent years in the diagnosis and treatment of breast cancer; however, breast cancer continues to be the most common and lethal cancer in women today. Early diagnosis is essential in order for treatmet to be given before the tumor spreads beyond the breast. The radiation risks of mammography have been greatly reduced with the use of newer low-dose techniques, and the benefits of mammography have increased because of a better understanding of the natural history of breast cancer, as well as improved methods of treatment. Radiologists must continue to take an active role in the early diagnosis of breast cancer. Continued research is needed in order to improve screening methods and to develop newer, noninvasive techniques

  14. Viscosupplementation for treatment of osteoarthritis: from initial discovery to current status and results.

    Science.gov (United States)

    Balazs, Endre A

    2004-01-01

    Viscosupplementation is a therapeutic modality based on the replacement of synovial fluid or exudates with an elastoviscous hyaluronan solution. The first clinical trials were carried out on race horses with painful osteoarthritis of traumatic origin. In the early 1970s, the clinical trials were extended to painful osteoarthritis in humans. Analgesic effects lasting longer than the residence time of the injected hyaluronan in joints were reported both in horses and humans. The hyaluronan used was a noninflammatory fraction of the molecule with an average molecular weight of 2-3 million at a 1% concentration. The analgesic effect of this elastoviscous hyaluronan solution was demonstrated in behavioral animal pain models. Later it was shown that the elastoviscous properties of hyaluronan solutions are the determining factors in reducing pain-elicited nerve activity in both normal and inflamed cat and rat joints. It also was demonstrated in animal arthritis models that elastoviscous hyaluronan solutions promote the healing of traumatic intra-articular wounds. From the mid-1980s, several hyaluronan preparations of greatly varying average molecular weight but with the same concentration were introduced as viscosupplementation-based therapeutic agents. The elastoviscous properties of these solutions varied also, because of the greatly varying average molecular weights (0.5-6.0 million), imitating the rheological properties of either healthy or pathological synovial fluid. Currently, viscosupplementation products available worldwide vary greatly in their elastoviscous properties, and their dosage is not standardized in terms of frequency of injections required or in regard to the removal of exudates before injection. The question of which patient at what stage of the disease responds best with long-lasting pain relief to the many therapeutic products marketed with greatly varying elastoviscous properties has not yet been answered. At the same time, viscosupplementation

  15. Engineered barriers: current status

    International Nuclear Information System (INIS)

    Atkinson, A.; Marsh, G.P.

    1988-01-01

    This report summarises the current state of research relevant to assessing the performance of engineered barriers made of steel and concrete in radioactive waste repositories. The objective of these barriers is to contain the radionuclides within them by providing both physical and chemical impediment to their release. The physical barriers are of most value for highly soluble isotopes with relatively short half-lives (eg 137 Cs), since they can provide containment until a large fraction of the activity has decayed. In addition they can facilitate retrievability for some period after disposal. The chemical barriers operate by beneficial conditioning of the near field groundwater and providing sites for sorption of radionuclides. Both of these reduce the aqueous concentration of radionuclides in the near field. (author)

  16. Intraoperative radiotherapy - Current status

    International Nuclear Information System (INIS)

    Gunderson, Leonard L.; Willett, Christopher G.; Harrison, Louis B.

    1997-01-01

    Purpose/Objective: Intraoperative irradiation (IORT) in its broadest sense refers to the delivery of irradiation at the time of an operation. This refresher course will discuss the use of both electrons (IOERT) and high dose rate brachytherapy (IOHDR) in conjunction with surgical exploration and resection ± external irradiation/chemotherapy. Both IORT methods have evolved with similar philosophies as an attempt to achieve higher effective doses of irradiation while dose limiting structures are surgically displaced. The rationale for each is supported by excellent local control ± survival results achieved with brachytherapy alone or as a boost to external irradiation in organ preservation efforts in traditional sites (head and neck, breast, gynecologic) wherein a boost dose could be delivered to smaller volumes than could usually be accomplished with external irradiation alone. IOERT has been a tool in modern radiotherapy in Japan since the 1960's and in the U.S. since the mid 1970's. Results from randomized and nonrandomized trials will be presented in the refresher course with major emphasis on GI sites (gastric, pancreas, colorectal) since the data is more mature. While the largest clinical experience with IOERT (± external irradiation/chemotherapy, maximal resection) has been with gastrointestinal cancers in adults, moderate experience has also been obtained with locally advanced retroperitoneal sarcomas and recurrent genitourinary and gynecologic cancers. With primary colorectal cancers that are unresectable for cure or for locally recurrent colorectal cancers, both local control and long-term survival appear to be improved with the aggressive combinations including IOERT when compared to results achieved with conventional treatment. When residual disease exists after resection of gastric cancers, IOERT ± external radiation has achieved optimistic survival results in trials in Japan, the U.S., Spain and China. With locally unresectable pancreatic cancer, an

  17. The current status of treatment for oropharyngeal cancer in Japan. A multi-institutional retrospective observation study

    International Nuclear Information System (INIS)

    Homma, Akihiro; Hayashi, Ryuichi; Kawabata, Kazuyoshi

    2013-01-01

    The purpose of this study was to assess the current status of the treatment for oropharyngeal cancer (OPC) in Japan to assist the planning of clinical trials in the future. The data for 523 patients with previously untreated OPC were obtained from 12 institutions from April 2005 to N/larch 2007. Of the 523 patients, 471 patients with squamous cell carcinoma and with curative intent were included in an analysis of the treatment and its results. Of the 471 patients with OPC treated with curative intent, 186 patients (39.5%) were treated with surgery, 118 (25.1%) with radiotherapy (RT) alone and 167 (355%) with CRT. Surgery was indicated for 60.4% of the patients with stage I, 47.8% in stage II, 29.4% in stage III, and 36.44% in stage IV. CRT was indicated for 8.3% in stage II, but the percentage increased with higher stage. The percentage of RT was around 30% among stage I-III, but in stage IV, 21.3% of the patients were indicated for RT. The median follow-up period was 4 years and 5 months. The 2-year and 5-year overall survival rates for the 471 patients were 85% and 69.9%, respectively. The 5-year overall survival rates for patients treated initially with surgery, RT and CRT were 73%, 69.1% and 65.6%, respectively. The 5-year overall survival rates for patients with stage I, II, III, IVA, and IVB were 78.9%. 87.3%, 69.7%, 66.6%, and 47.7%, respectively. Although this study was retrospective, we could understand the tendency of treatment choice according to various factors and treatment results. The information will be useful for planning clinical trials in the future. (author)

  18. Associations Between Pain, Current Tobacco Smoking, Depression, and Fibromyalgia Status Among Treatment-Seeking Chronic Pain Patients.

    Science.gov (United States)

    Goesling, Jenna; Brummett, Chad M; Meraj, Taha S; Moser, Stephanie E; Hassett, Afton L; Ditre, Joseph W

    2015-07-01

    As smoking impacts physiological pathways in the central nervous system, it is important to consider the association between smoking and fibromyalgia, a pain condition caused predominantly by central nervous system dysfunction. The objectives were to assess the prevalence of current smoking among treatment-seeking chronic pain patients with (FM+) and without (FM-) a fibromyalgia-like phenotype; test the individual and combined influence of smoking and fibromyalgia on pain severity and interference; and examine depression as a mediator of these processes. Questionnaire data from 1566 patients evaluated for a range of conditions at an outpatient pain clinic were used. The 2011 Survey Criteria for Fibromyalgia were used to assess the presence of symptoms associated with fibromyalgia. Current smoking was reported by 38.7% of FM+ patients compared to 24.7% of FM- patients. FM+ smokers reported higher pain and greater interference compared to FM+ nonsmokers, FM- smokers, and FM- nonsmokers. There was no interaction between smoking and fibromyalgia. Significant indirect effects of fibromyalgia and smoking via greater depression were observed for pain severity and interference. Current smoking and positive fibromyalgia status were associated with greater pain and impairment among chronic pain patients, possibly as a function of depression. Although FM+ smokers report the most negative clinical symptomatology (i.e., high pain, greater interference) smoking does not appear to have a unique association with pain or functioning in FM+ patients, rather the effect is additive. The 38.7% smoking rate in FM+ patients is high, suggesting FM+ smokers present a significant clinical challenge. © 2015 American Academy of Pain Medicine.

  19. The WIMP Paradigm: Current Status

    International Nuclear Information System (INIS)

    Feng, Jonathan

    2011-01-01

    The WIMP paradigm is the glue that joins together much of the high energy and cosmic frontiers. It postulates that most of the matter in the Universe is made of weakly-interacting massive particles, with implications for a broad range of experiments and observations. I will review the WIMP paradigm's underlying motivations, its current status in view of rapid experimental progress on several fronts, and recent theoretical variations on the WIMP paradigm theme.

  20. [Current status of diagnosis and treatment of community-acquired pneumonia in Shanghai revealed by a questionnaire analysis].

    Science.gov (United States)

    Liu, J; Zhang, J; Cheng, Q J; Xu, J F; Jie, Z J; Jiao, Y; Huang, Y; Qu, J M

    2018-04-12

    Objective: To understand the current status of diagnosis and treatment of community-acquired pneumonia (CAP) among doctors in various hospitals across Shanghai, for the purpose of promoting the 2016 clinical practice guidelines for adult CAP of China. Methods: A questionnaire was designed to address the common questions in CAP management. The responses were collected via WeChat and the data were analyzed. Results: A total of 1 254 valid questionnaires were received, 46.1% from tertiary , 26.4% from secondary and 27.5% from primary care hospitals. Of these valid respondents, 31.4% were respiratory physicians and 68.6% from non-respiratory physicians. When diagnosing CAP, 78.1% of the doctors would use chest CT in more than 50% of the patients. Regarding the tools for evaluating the severity of CAP, 60.3% of the respondents would prefer CURB-65. "Respiratory failure requiring mechanical ventilation and septic shock" were the most common criteria for admission to ICU. Blood culture was not widely used in severe CAP regardless of the level of hospitals ( P >0.05). The results of this survey showed that the top 5 pathogenic microorganisms of CAP were Streptococcus pneumoniae, Mycoplasma pneumoniae, Klebsiella pneumoniae, Haemophilus influenza and Chlamydia pneumoniae. For non-severe CAP patients, all the doctors tended to select monotherapy. The most frequently used antimicrobial regimen for severe CAP was third- or fourth-generation cephalosporin monotherapy. As for combination therapy, the most frequently used regimen in tertiary hospitals was "carbapenem plus vancomycin" , while in primary and secondary hospitals it was "β-lactams plus macrolides" . More doctors from primary hospitals and non-respiratory medicine would consider "complete resolution of pulmonary opacity" as the indication to discontinue antimicrobial therapy or to discharge patients, and "prolonged high fever" , "large area consolidation" , "multiple lobe-segment involvement " as the indication for

  1. Dark Matter Detection: Current Status

    International Nuclear Information System (INIS)

    Akerib, Daniel S.

    2011-01-01

    Overwhelming observational evidence indicates that most of the matter in the Universe consists of non-baryonic dark matter. One possibility is that the dark matter is Weakly-Interacting Massive Particles (WIMPs) that were produced in the early Universe. These relics could comprise the Milky Way's dark halo and provide evidence for new particle physics, such as Supersymmetry. This talk focuses on the status of current efforts to detect dark matter by testing the hypothesis that WIMPs exist in the galactic halo. WIMP searches have begun to explore the region of parameter space where SUSY particles could provide dark matter candidates.

  2. The influence of patients' nutritional status on the prevalence, course and treatment outcomes of lower limb ischemia: an overview of current evidence.

    Science.gov (United States)

    Spychalska-Zwolińska, Marta; Zwoliński, Tomasz; Anaszewicz, Marzena; Budzyński, Jacek

    2018-04-01

    The association of lower limb ischemia (LLI) with disturbances in nutritional status, in respect to over- or undernutrition, is still uncertain. The aim of this study was to present the current state of knowledge on this issue. Systematic review of papers published between 2006 and 2018. The literature shows inconclusive evidence regarding the impact of nutritional status on the risk, course, prognosis and outcomes of conservative and invasive treatment of LLI. The majority of publications available demonstrate greater LLI prevalence in overweight and obese patients, a worse prognosis both in malnourished and severely obese patients, poorer outcomes of invasive treatment in underweight patients, and better results for endovascular and surgical treatment in patients with overweight and class I obesity, although without such a relationship for conservative therapy. Possible explanations linking nutritional status and LLI seem to be: the endocrine, paracrine, and autocrine activity of adipose tissue, a decrease in physical activity, and the effect of diet-dependent comorbidities, e.g. diabetes mellitus, hypertension and dyslipidemia. There is a growing body of evidence concerning an association between LLI and patients' nutritional status. A so-called "obesity paradox" or "BMI paradox" seems to exist among patients with LLI and mainly concerns outcomes of endovascular and surgical treatment. However, further studies are needed to evaluate the clinical importance of body composition, the distribution and endocrine activity of adipose tissue, and the effect of weight reduction and/or nutritional support in the LLI patient group.

  3. Cancer pain management-current status

    Directory of Open Access Journals (Sweden)

    Deepak Thapa

    2011-01-01

    Full Text Available Cancer pain is still one of the most feared entities in cancer and about 75% of these patients require treatment with opioids for severe pain. The cancer pain relief is difficult to manage in patients with episodic or incidental pain, neuropathic pain, substance abuse and with impaired cognitive or communication skills. This non-systematic review article aims to discuss reasons for under treatment, tools of pain assessment, cancer pain and anxiety and possibly carve new approaches for cancer pain management in future. The current status of World Health Organization analgesic ladder has also been reviewed. A thorough literature search was carried out from 1998 to 2010 for current status in cancer pain management in MEDLINE, WHO guidelines and published literature and relevant articles have been included.

  4. Incremental Innovation and Progress in Advanced Squamous Cell Lung Cancer: Current Status and Future Impact of Treatment.

    Science.gov (United States)

    Langer, Corey J; Obasaju, Coleman; Bunn, Paul; Bonomi, Philip; Gandara, David; Hirsch, Fred R; Kim, Edward S; Natale, Ronald B; Novello, Silvia; Paz-Ares, Luis; Pérol, Maurice; Reck, Martin; Ramalingam, Suresh S; Reynolds, Craig H; Socinski, Mark A; Spigel, David R; Wakelee, Heather; Mayo, Carlos; Thatcher, Nick

    2016-12-01

    Squamous cell lung cancer (sqCLC) is an aggressive form of cancer that poses many therapeutic challenges. Patients tend to be older, present at a later stage, and have a high incidence of comorbidities, which can compromise treatment delivery and exacerbate toxicity. In addition, certain agents routinely available for nonsquamous cell histologic subtypes, such as bevacizumab and pemetrexed, are contraindicated or lack efficacy in sqCLC. Therapeutic progress has been much slower for advanced sqCLC, with median survival times of approximately 9 to 11 months in most studies. Herein, we discuss the current therapeutic landscape for patients with sqCLC versus with nonsquamous NSCLC. Current evidence indicates that new targeted treatments, notably monoclonal antibodies such as ramucirumab and necitumumab, and immunotherapies such as nivolumab and pembrolizumab can provide survival prolongation, although the benefits are still relatively modest. These incremental improvements, all realized since 2012, in aggregate, will very likely have a clinically meaningful impact for patients with sqCLC. We also discuss recent genomic studies of sqCLC that have identified potentially actionable molecular targets, as well as the relevant targeted agents in clinical development. Finally, we discuss the magnitude of survival benefit and the risk-to-benefit ratio that would prove clinically meaningful in this underserved patient population with unmet needs. Copyright © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

  5. Current status of nuclear power

    International Nuclear Information System (INIS)

    Behnke, W.B.

    1984-01-01

    The decision to devote the 1984 conference to nuclear power is timely and appropriate. Illinois has a long, and distinguished history in the development of civilian nuclear power. The concept was born at the University of Chicago, developed at Argonne National Laboratory and demonstrated on the Commonwealth Edison system at our pioneer Dresden Nuclear Station. Today, Illinois ranks number one in the nation in nuclear generation. With over a quarter century of commercial operating experience, nuclear power has proven its worth and become a significant and growing component of electric power supply domestically and throughout the world. Despite its initial acceptance, however, the nuclear power industry in the U.S. is now in the midst of a difficult period of readjustment stemming largely from the economic and regulatory problems of the past decade. As a result, the costs of plants under construction have increased dramatically, causing serious financial difficulties for several projects and their owners. At the same time, the U.S. is facing hard choices concerning its future energy supplies. Conferences such as this have an important role in clarifying the issues and helping to find solutions to today's pressing energy problems. This paper summarizes the status of nuclear power both here and abroad, discussing the implications of current events in the context of national energy policy and economic development here in Illinois

  6. Current status of diuretic renography

    International Nuclear Information System (INIS)

    O'Reilly, P.H.

    1987-01-01

    Percutaneous antegrade perfusion studies constitute a valuable contribution to the investigation of obstructive uropathy. In 1978, the first report of application of diuretic renogram techniques to this problem appeared in the literature. This was the first systematic report of a standardized protocol to be applied to a specific surgical problem. The purpose of the procedure, as with perfusion pressure-flow studies, is to help distinguish between a dilated urinary tract that is obstructed and requires surgery and a nonobstructed system in which urographic dilation and stasis mimic obstruction, but no genuine impedance to urine flow exists, and surgery is not required. The technique provides dual information. It gives quantitative data on individual renal function that perfusion pressure-flow studies do not, and it gives time-activity curves reflecting the urodynamics through the individual upper urinary tracts at normal and high urinary flow rates. In the early days, this information was obtained from probe studies, but the procedure is now almost exclusively performed using the gamma camera, images from which give additional information on the site of any suspected obstruction. In some ways, the development of diuretic renography and that of perfusion pressure-flow studies have proceeded in a competitive fashion, both attempting to answer the same questions by different means. In practice, however, the two tests would be regarded as complementary, as will be shown later in this chapter. The following sections describe the technique of diuretic renography, its current clinical application and status in surgical and nuclear medicine practice, and its role in comparison with other available tests for management of the dilated upper urinary tract

  7. The current status of opioid maintenance treatment in France: a survey of physicians, patients, and out-of-treatment opioid users

    Directory of Open Access Journals (Sweden)

    Benyamina A

    2014-09-01

    Full Text Available Amine Benyamina National Institute for Medical Research (INSERM U-669, Hôpital Universitaire Paul Brousse, 94804 Villejuif, France Aim: Project Access France was a national survey designed to provide real-world observations on the status of opioid dependence treatment in France. Methods: The views of physicians (n=100, patients (n=130, and out-of-treatment opioid users (n=33 were collected via interviews and questionnaires. Results: Physicians reported being moderately satisfied with treatment programs in their area (rating 6.9 out of 10. Most physicians (82% reported being concerned about misuse and diversion of medication-assisted treatment (MAT medications and 50% identified psychosocial/behavioral counseling as the key change that would most improve patient care. Among patients, the mean number of previous MAT episodes was low (1.5; 78% reported that it was easy to access a doctor to undergo MAT; 14% reported regularly or sometimes using heroin; misuse and diversion were reported in 15% and 39% of patients, respectively; and 57% of patients were not receiving psychosocial help. Out-of-treatment opioid users reported using drugs on a regular basis (42% regularly used heroin and cited 'not wanting to give up drugs completely' as the most frequent reason for staying out of MAT. Conclusion: This survey highlights a number of positive features of the open-access, GP-based treatment model for opioid dependence in France. Challenges remain with regard to continued misuse/diversion of MAT medications and limited patient access to psychosocial support. Keywords: opioid maintenance treatment, medication-assisted treatment, buprenorphine, methadone, buprenorphine–naloxone, France

  8. Current status of laparoscopic central pancreatectomy

    Directory of Open Access Journals (Sweden)

    CAO Yang

    2017-04-01

    Full Text Available Central pancreatectomy is an ideal surgical procedure for the treatment of benign or low-grade malignant tumors in the pancreatic neck or the proximal body of the pancreas, and it can preserve more normal pancreatic tissue in order to reduce the incidence of endocrine and exocrine insufficiency after surgery. Although some clinical studies have demonstrated the feasibility and safety of this procedure, laparoscopic central pancreatectomy was technically challenging with a few number of cases. This article reviews the current status of laparoscopic central pancreatectomy and introduces our clinical experience of laparoscopic central pancreatectomy and pancreaticojejunostomy.

  9. Processes of Change in Cognitive-Behavioural Treatment of Obsessive-Compulsive Disorder : Current Status and Some Future Directions

    NARCIS (Netherlands)

    Polman, Annemiek; Bouman, Theo K.; van Hout, Wiljo J. P. J.; de Jong, Peter J.; den Boer, Johan A.

    2010-01-01

    The present paper discusses theoretical and methodological issues involved in the processes of change in cognitive-behavioural treatment (CBT) of obsessive-compulsive disorder (OCD). Treatment outcome studies showed that CBT is effective in reducing obsessive-compulsive symptoms. However, why and

  10. [Current status of thoracoscopic surgery for thoracic and lumbar spine. Part 2: treatment of the thoracic disc hernia, spinal deformities, spinal tumors, infections and miscellaneous].

    Science.gov (United States)

    Verdú-López, Francisco; Beisse, Rudolf

    2014-01-01

    Thoracoscopic surgery or video-assisted thoracic surgery (VATS) of the thoracic and lumbar spine has evolved greatly since it appeared less than 20 years ago. It is currently used in a large number of processes and injuries. The aim of this article, in its two parts, is to review the current status of VATS of the thoracic and lumbar spine in its entire spectrum. After reviewing the current literature, we developed each of the large groups of indications where VATS takes place, one by one. This second part reviews and discusses the management, treatment and specific thoracoscopic technique in thoracic disc herniation, spinal deformities, tumour pathology, infections of the spine and other possible indications for VATS. Thoracoscopic surgery is in many cases an alternative to conventional open surgery. The transdiaphragmatic approach has made endoscopic treatment of many thoracolumbar junction processes possible, thus widening the spectrum of therapeutic indications. These include the treatment of spinal deformities, spinal tumours, infections and other pathological processes, as well as the reconstruction of injured spinal segments and decompression of the spinal canal if lesion placement is favourable to antero-lateral approach. Good clinical results of thoracoscopic surgery are supported by growing experience reflected in a large number of articles. The degree of complications in thoracoscopic surgery is comparable to open surgery, with benefits in regard to morbidity of the approach and subsequent patient recovery. Copyright © 2012 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

  11. Current status of baryon spectroscopy

    International Nuclear Information System (INIS)

    Wali, K.C.

    1975-01-01

    The basic ideas of some of the current models and the experimental numerical comparisons are discussed briefly. Included are realistic or constituent quark models, experimental comparison, the experimental and theoretical basis for the assignments, algebraic quark models, and confinement schemes

  12. Current status of baryon spectroscopy

    International Nuclear Information System (INIS)

    Wali, K.C.

    1975-08-01

    In this review of baryon spectroscopy, the basic ideas of some of the current models and the experimental data for their claims to success are discussed including realistic or constituent quark models, experimental comparison, the experimental and theoretical basis for the assignments, algebraic quark models, and confinement schemes

  13. The current status of the treatment for T4 maxillary sinus cancer in Japan. A multi-institutional retrospective observation study

    International Nuclear Information System (INIS)

    Homma, Akihiro; Hayashi, Ryuichi; Matsuura, Kazuto

    2013-01-01

    The purpose of this study was to assess the current status in Japan of the treatment for squamous cell carcinoma of the T4 maxillary sinus (MS-SCC) and its use to plan clinical trials in the future. The data for 128 patients with previously untreated MS-SCC were obtained from 28 institutions from 2006 to 2007. Of the 128 patients, 118 patients with curative intent were included in an analysis of the treatment and its results. Of the 118 patients, 73 patients had T4a disease, and 45 with T4b. Thirty-nine patients (33.1%) were treated with total maxillectomy, 25 (21.2%) with partial maxillectomy, 22 patients (18.6%) with RADPLAT, 19 patients (16.1%) with IV-CRT, and 13 patients (11.0%) with others. The 5-year overall survival rate and local control rate for 118 patients were 49.8% and 48.9%, respectively. The 5-year overall survival rates for patients with T4aN0M0 and T4bN0M0 were 67.5% and 29.8%, respectively. This study was retrospective, but we could understand the tendency of treatment choice and treatment results. It will be useful information to plan clinical trials in the future. (author)

  14. Stemless shoulder arthroplasty: current status.

    Science.gov (United States)

    Churchill, R Sean

    2014-09-01

    Since the original Neer humeral replacement in the 1950s, the standard primary anatomic total shoulder arthroplasty design has slowly evolved. Most recently, the humeral stem has become progressively shorter to help combat stem-related complications. Currently, there are several companies who have developed and marketed a stemless humeral arthroplasty component. Manufacturers' data for 5 stemless shoulder arthroplasty components currently on the market were analyzed and reviewed. A literature review of short-term results for stemless shoulder arthroplasty was completed. Of the stemless shoulder arthroplasty systems available on the market, 3 are currently undergoing clinical trials in the United States. The Tornier Simpliciti (Tornier, Edina, MN, USA) clinical trial began in 2011. The study with 2-year minimum follow-up results is scheduled for completion in November 2014. The Arthrex Eclipse (Arthrex, Naples, FL, USA) clinical trial was started in January 2013. The tentative study completion date is 2017. The Biomet Nano (Biomet, Warsaw, IN, USA) clinical trial began in October 2013 and also has a tentative completion date of 2017. No other clinical trial is currently under way in the United States. Early results for stemless shoulder arthroplasty indicate clinical results similar to standard stemmed shoulder arthroplasty. Radiographic analysis indicates implant stability without migration or subsidence at 2- to 3-year minimum follow-up.. Several stemless shoulder arthroplasty implants are available outside the United States. Early clinical and radiographic results are promising, but well-designed clinical studies and midterm results are lacking. Three clinical trials are currently under way in the United States with initial availability for use anticipated in 2015. Copyright © 2014 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

  15. Current status of rotavirus vaccines.

    Science.gov (United States)

    Wang, Ching-Min; Chen, Shou-Chien; Chen, Kow-Tong

    2015-11-01

    Rotaviruses remain the major cause of childhood diarrheal disease worldwide and of diarrheal deaths of infants and children in developing countries. The huge burden of childhood rotavirus-related diarrhea in the world continues to drive the remarkable pace of vaccine development. Research articles were searched using terms "rotavirus" and "rotavirus vaccine" in MEDLINE and PubMed. Articles not published in the English language, articles without abstracts, and opinion articles were excluded from the review. After preliminary screening, all articles were reviewed and synthesized to provide an overview of current vaccines and vaccination programs. In this review of the global rotavirus vaccines and vaccination programs, the principles of rotavirus vaccine development and the efficacy of the currently licensed vaccines from both developed and developing countries were summarized. Rotavirus is a common cause of diarrhea in children in both developed and developing countries. Rotavirus vaccination is a cost-effective measure to prevent rotavirus diarrhea.

  16. Current Status of RENO Experiment

    International Nuclear Information System (INIS)

    Kim, Soo-Bong

    2010-01-01

    The RENO (Reactor Experiment for Neutrino Oscillation) is under construction to measure the value of the smallest and unknown neutrino mixing angle θ 13 . The experiment will compare the measured fluxes of electron antineutrinos at two detectors located at 290 m and 1.4 km distances from the center of the Yonggwang nuclear reactors in Korea, with world-second largest thermal power output of 16.4 GW. Construction of experimental halls and access tunnels for both near and far detector sites was completed in early 2009. The detectors are near completion, and data-taking is planned to start in mid 2010. An expected number of observed antineutrino is roughly 510 and 80 per day in the near detector and far detector, respectively. An estimated systematic uncertainty associated with the measurement is less than 0.6%, and an expected statistical error is about 0.3%. With three years of data, the experiment will search for the mixing angle values of sin 2 (2θ 13 ) down to 0.02 in 90% C.L. limit. In this talk, the construction status will be presented. (author)

  17. Current Status of Spent Fast Reactor Fuel Reprocessing and Waste Treatment in Various Countries: United States of America

    International Nuclear Information System (INIS)

    2011-01-01

    -refining of actinide metals and oxides. The processes that won through to greatest acceptance internationally are considered to be metal electro-refining, oxide electrowinning and fluoride volatility. The first one of these has been the most successful in the USA. Spent fuel reprocessing is not currently performed in the USA on a commercial scale. The emphasis remains on spent fuel storage. Vitrification of some defence wastes has, however, been carried out. Efforts to clean up the accumulated wastes in old weapons laboratories by converting them into glass or glass-ceramic matrices are also underway. Currently, there is renewed interest in the use of metallic fuel in FRs in view of the possibility of achieving better breeding ratios and also actinide burning. EBR-II has accumulated a lot of operating experience with metallic fuel, both with respect to its in-pile behaviour, and reprocessing and waste management

  18. Role of Omega-3 Fatty Acids in the Etiology, Treatment, and Prevention of Depression: Current Status and Future Directions

    Science.gov (United States)

    McNamara, Robert K.

    2016-01-01

    Over the past three decades a body of translational evidence has implicated dietary deficiency in long-chain omega-3 (LCn-3) fatty acids, including eicosapenaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of major depressive disorder (MDD). Cross-national and cross-sectional data suggest that greater habitual intake of preformed EPA+DHA is associated with reduced risk for developing depressive symptoms and syndromal MDD. Erythrocyte EPA and DHA composition is highly correlated with habitual fish or fish oil intake, and case-control studies have consistently observed lower erythrocyte EPA and/or DHA levels in patients with MDD. Low erythrocyte EPA+DHA composition may also be associated with increased risk for suicide and cardiovascular disease, two primary causes of excess premature mortality in MDD. While controversial, dietary EPA+DHA supplementation may have antidepressant properties and may augment the therapeutic efficacy of antidepressant medications. Neuroimaging and rodent neurodevelopmental studies further suggest that low LCn-3 fatty acid intake or biostatus can recapitulate central pathophysiological features associated with MDD. Prospective findings suggest that low LCn-3 fatty acid biostatus increases risk for depressive symptoms in part by augmenting pro-inflammatory responsivity. When taken collectively, these translational findings provide a strong empirical foundation in support of dietary LCn-3 fatty acid deficiency as a modifiable risk factor for MDD. This review provides an overview of this translational evidence and then discusses future directions including strategies to translate this evidence into routine clinical screening and treatment algorithms. PMID:27766299

  19. Current status of radiation processing

    International Nuclear Information System (INIS)

    Silverman, J.

    1979-01-01

    A summary is presented of recent developments and problems in the field of radiation processing. Examples are given of a wide range of industrial products and processes. Irradiation plants are discussed. Cross-linking and sterilization are still the principal areas of success. Some setbacks are mentioned, including the appearance of regulatory codes forbidding the use of high energy electrons in the irradiation of food packing materials. Promising applications, such as food sterilization, treatment of sewage and other wastes, chemical synthesis and the curing of paints. The need for more fundamental work on radiation chemistry is stressed. (U.K.)

  20. Current Treatments of Bruxism.

    Science.gov (United States)

    Guaita, Marc; Högl, Birgit

    2016-02-01

    Despite numerous case reports, the evidence for treatment of bruxism is still low. Different treatment modalities (behavioral techniques, intraoral devices, medications, and contingent electrical stimulation) have been applied. A clinical evaluation is needed to differentiate between awake bruxism and sleep bruxism and rule out any medical disorder or medication that could be behind its appearance (secondary bruxism). A polysomnography is required only in a few cases of sleep bruxism, mostly when sleep comorbidities are present. Counselling with regard to sleep hygiene, sleep habit modification, and relaxation techniques has been suggested as the first step in the therapeutic intervention, and is generally considered not harmful, despite low evidence of any efficacy. Occlusal splints are successful in the prevention of dental damage and grinding sounds associated with sleep bruxism, but their effects on reducing bruxism electromyographic (EMG) events are transient. In patients with psychiatric and sleep comorbidities, the acute use of clonazepam at night has been reported to improve sleep bruxism, but in the absence of double-blind randomized trials, its use in general clinical practice cannot be recommended. Severe secondary bruxism interfering with speaking, chewing, or swallowing has been reported in patients with neurological disorders such as in cranial dystonia; in these patients, injections of botulinum toxin in the masticatory muscles may decrease bruxism for up to 1-5 months and improve pain and mandibular functions. Long-term studies in larger and better specified samples of patients with bruxism, comparing the effects of different therapeutic modalities on bruxism EMG activity, progression of dental wear, and orofacial pain are current gaps of knowledge and preclude the development of severity-based treatment guidelines.

  1. The current status of radiosurgery

    International Nuclear Information System (INIS)

    Mehta, Minesh P.

    1996-01-01

    Objectives: Review the role of radiosurgery in recurrent malignant gliomas for palliative purposes. Review the role of radiosurgery in newly diagnosed malignant glioma as boost therapy and emphasize the randomized clinical trials underway. Review the role of radiosurgery in the management of patients with brain metastases and emphasize the major prognostic factors. Review the recently initiated clinical trials for brain metastases using radiosurgery. Review the role of radiosurgery in the management of benign tumors with specific emphasis on meningioma and acoustic neuroma. Emphasize the rationale for fractionation and present the preliminary results of fractionated stereotactic radiation. Stereotactic localization techniques, originally designed for neurosurgery, have been used to delivery high single doses of radiation to small intracranial targets for more than 25 years, a technique referred to as stereotactic radiosurgery. Radiosurgery has proven to be an attractive alternative to surgery in the management of several benign tumors, such as vestibular schwannomas with better preservation of hearing and facial nerve function than microsurgical resection. For other benign tumors such as meningioma and pituitary adenoma, preliminary results are promising, but longer range studies to confirm high tumor control rates are necessary. For patients with malignant glioma, radiosurgery has been used to escalate the radiation dose to enhance tumor control following surgery and radiation therapy. The rationale for this is grounded in the recent confirmatory randomized prospective trial verifying the value of brachytherapy in this disease. The results of radiosurgery from single institutional experiences for primary and recurrent malignant glioma indicate a palliative benefit as well as a potential survival benefit in a select sub-group of patients based on the appropriate mix of prognostic criteria such as patient age, performance status, tumor size and extent of resection

  2. Engineered barriers: current status 1989

    International Nuclear Information System (INIS)

    Atkinson, A.; Marsh, G.B.

    1989-06-01

    This report summarises the current state of research relevant to assessing the performance of engineered barriers made of steel and concrete in radioactive waste repositories. The objective of these barriers is to contain substantially the radionuclides within them by providing both physical and chemical impediment to their release. The physical barriers are of most value for highly soluble isotopes with relatively short half-lives (eg 137 Cs), since they can provide a measure of containment until a large fraction of the activity has decayed. In addition they can facilitate retrievability for some period after disposal. The chemical barriers operate by beneficial conditioning of the near field groundwater and providing sites for sorption of radionuclides. Both of these reduce the aqueous concentration of radionuclides in the near field. (author)

  3. Coronary MR angiography: current status

    International Nuclear Information System (INIS)

    Danias, P.G.; Manning, W.J.

    2000-01-01

    Since first described in the early 1990s, coronary magnetic resonance angiography (MRA) has evolved as a promising noninvasive modality for imaging of the coronary arteries and evaluation of coronary artery disease. Despite technical limitations, coronary MRA has established value for imaging of anomalous coronary arteries and assessment of bypass graft patency. Current research focuses on the development of optimal respiratory compensation strategies, improved spatial and temporal resolution and faster acquisition of image data. The accurate detection of stenoses and assessment of the severity of coronary atherosclerosis is presently being evaluated with large multi-center studies. With further technique enhancements and more clinical experience, coronary MRA is likely to become the dominant noninvasive modality in clinical cardiology. (orig.) [de

  4. Interventional Radiology of Male Varicocele: Current Status

    International Nuclear Information System (INIS)

    Iaccarino, Vittorio; Venetucci, Pietro

    2012-01-01

    Varicocele is a fairly common condition in male individuals. Although a minor disease, it may cause infertility and testicular pain. Consequently, it has high health and social impact. Here we review the current status of interventional radiology of male varicocele. We describe the radiological anatomy of gonadal veins and the clinical aspects of male varicocele, particularly the physical examination, which includes a new clinical and ultrasound Doppler maneuver. The surgical and radiological treatment options are also described with the focus on retrograde and antegrade sclerotherapy, together with our long experience with these procedures. Last, we compare the outcomes, recurrence and persistence rates, complications, procedure time and cost-effectiveness of each method. It clearly emerges from this analysis that there is a need for randomized multicentre trials designed to compare the various surgical and percutaneous techniques, all of which are aimed at occlusion of the anterior pampiniform plexus.

  5. Interventional Radiology of Male Varicocele: Current Status

    Energy Technology Data Exchange (ETDEWEB)

    Iaccarino, Vittorio, E-mail: vittorio.iaccarino@unina.it; Venetucci, Pietro [University of Naples ' Federico II' , Diagnostic Imaging Department-Cardiovascular and Interventional Radiology, School of Medicine (Italy)

    2012-12-15

    Varicocele is a fairly common condition in male individuals. Although a minor disease, it may cause infertility and testicular pain. Consequently, it has high health and social impact. Here we review the current status of interventional radiology of male varicocele. We describe the radiological anatomy of gonadal veins and the clinical aspects of male varicocele, particularly the physical examination, which includes a new clinical and ultrasound Doppler maneuver. The surgical and radiological treatment options are also described with the focus on retrograde and antegrade sclerotherapy, together with our long experience with these procedures. Last, we compare the outcomes, recurrence and persistence rates, complications, procedure time and cost-effectiveness of each method. It clearly emerges from this analysis that there is a need for randomized multicentre trials designed to compare the various surgical and percutaneous techniques, all of which are aimed at occlusion of the anterior pampiniform plexus.

  6. REACH and nanomaterials: current status

    International Nuclear Information System (INIS)

    Alessandrelli, Maria; Di Prospero Fanghella, Paola; Polci, Maria Letizia; Castelli, Stefano; Pettirossi, Flavio

    2015-01-01

    New challenges for regulators are emerging about a specific assessment and appropriate management of the potential risks of nanomaterials. In the framework of European legislation on chemicals, Regulation (EC) No. 1907/2006 REACH aims to ensure the safety of human health and the environment through the collection of information on the physico-chemical characteristics of the substances and on their profile (eco) toxicological and the identification of appropriate risk management linked to 'exposure to these substances without impeding scientific progress and the competitiveness of industry. In order to cover the current shortage of information on the safety of nanomaterials and tackle the acknowledged legal vacuum, are being a rich activities, carried out both by regulators both by stake holders, and discussions on the proposals for adapting the European regulatory framework for chemicals . The European Commission is geared to strengthen the REACH Regulation by means of updates of its annexes. The importance of responding to the regulatory requirements has highlighted the need for cooperation between European organizations, scientists and industries to promote and ensure the safe use of nanomaterials. [it

  7. The status of neutral currents

    International Nuclear Information System (INIS)

    Zwirner, F.

    1987-11-01

    The situation of particle physics today is quite puzzling. On the one hand, the Standard Model (SM) of strong and electroweak interactions is consistent with all confirmed experimental data but theoretically rather unsatisfactory. On the other hand, none of the many theoretical speculations which try to go beyond the SM has (yet) received the slightest experimental support. The solution to this dilemma can only come from new data: either from the detection of a new particle threshold at high energy colliders, or from the appearance of some small discrepancy in high-precision experiments. A crucial sector for testing the SM and its extensions is that of neutral currents (NC), where an impressive amount of data has been collected in recent years. While waiting for the next generation of experiments, it is certainly useful to take stock of our knowledge, determining the NC parameters as precisely as we can and putting limits on possible deviations from the SM. The present talk contains the results of a recent analysis along these lines: the first part illustrates how a set of 'model-independent' parameters can be extracted from the available NC data, the second part particularizes the analysis to the SM and to some superstring-inspired models with an additional Z' in their low-energy spectrum. 27 refs., 3 figs., 1 tab

  8. Current status and prospects for Chernobyl Ukritiye

    International Nuclear Information System (INIS)

    Jampsin, B.

    1996-01-01

    Current status and prospects for Chernobyl Ukritiye (sarcophagus) are described, including the following issues: the accident; the sarcophagus; the radioactive inventory; the design basis criteria; the analysis of the present state; a way forward

  9. Health Status of Current National Guard Members

    National Research Council Canada - National Science Library

    Proctor, Susan P

    2005-01-01

    .... The objectives are to: 1) describe the current health status of this ARNG cohort, 2) examine to what extent the job strain of ARNG service affects the relationship between Civilian job strain and health and job performance outcomes and, 3...

  10. Current status of rotational atherectomy.

    Science.gov (United States)

    Tomey, Matthew I; Kini, Annapoorna S; Sharma, Samin K

    2014-04-01

    Rotational atherectomy facilitates percutaneous coronary intervention for complex de novo lesions with severe calcification. A strategy of routine rotational atherectomy has not, however, conferred reduction in restenosis or major adverse cardiac events. As it is technically demanding, rotational atherectomy is also uncommon. At this 25-year anniversary since the introduction of rotational atherectomy, we sought to review the current state-of-the-art in rotational atherectomy technique, safety, and efficacy data in the modern era of drug-eluting stents, strategies to prevent and manage complications, including slow-flow/no-reflow and burr entrapment, and appropriate use in the context of the broader evolution in the management of stable ischemic heart disease. Fundamental elements of optimal technique include use of a single burr with burr-to-artery ratio of 0.5 to 0.6-rotational speed of 140,000 to 150,000 rpm, gradual burr advancement using a pecking motion, short ablation runs of 15 to 20 s, and avoidance of decelerations >5,000 rpm. Combined with meticulous technique, optimal antiplatelet therapy, vasodilators, flush solution, and provisional use of atropine, temporary pacing, vasopressors, and mechanical support may prevent slow-flow/no-reflow, which in contemporary series is reported in 0.0% to 2.6% of cases. On the basis of the results of recent large clinical trials, a subset of patients with complex coronary artery disease previously assigned to rotational atherectomy may be directed instead to medical therapy alone or bypass surgery. For patients with de novo severely calcified lesions for which rotational atherectomy remains appropriate, referral centers of excellence are required. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  11. rasdaman Array Database: current status

    Science.gov (United States)

    Merticariu, George; Toader, Alexandru

    2015-04-01

    rasdaman (Raster Data Manager) is a Free Open Source Array Database Management System which provides functionality for storing and processing massive amounts of raster data in the form of multidimensional arrays. The user can access, process and delete the data using SQL. The key features of rasdaman are: flexibility (datasets of any dimensionality can be processed with the help of SQL queries), scalability (rasdaman's distributed architecture enables it to seamlessly run on cloud infrastructures while offering an increase in performance with the increase of computation resources), performance (real-time access, processing, mixing and filtering of arrays of any dimensionality) and reliability (legacy communication protocol replaced with a new one based on cutting edge technology - Google Protocol Buffers and ZeroMQ). Among the data with which the system works, we can count 1D time series, 2D remote sensing imagery, 3D image time series, 3D geophysical data, and 4D atmospheric and climate data. Most of these representations cannot be stored only in the form of raw arrays, as the location information of the contents is also important for having a correct geoposition on Earth. This is defined by ISO 19123 as coverage data. rasdaman provides coverage data support through the Petascope service. Extensions were added on top of rasdaman in order to provide support for the Geoscience community. The following OGC standards are currently supported: Web Map Service (WMS), Web Coverage Service (WCS), and Web Coverage Processing Service (WCPS). The Web Map Service is an extension which provides zoom and pan navigation over images provided by a map server. Starting with version 9.1, rasdaman supports WMS version 1.3. The Web Coverage Service provides capabilities for downloading multi-dimensional coverage data. Support is also provided for several extensions of this service: Subsetting Extension, Scaling Extension, and, starting with version 9.1, Transaction Extension, which

  12. Treatment of Established Status Epilepticus.

    Science.gov (United States)

    Falco-Walter, Jessica J; Bleck, Thomas

    2016-04-25

    Status epilepticus is the most severe form of epilepsy, with a high mortality rate and high health care costs. Status epilepticus is divided into four stages: early, established, refractory, and super-refractory. While initial treatment with benzodiazepines has become standard of care for early status epilepticus, treatment after benzodiazepine failure (established status epilepticus (ESE)) is incompletely studied. Effective treatment of ESE is critical as morbidity and mortality increases dramatically the longer convulsive status epilepticus persists. Phenytoin/fosphenytoin, valproic acid, levetiracetam, phenobarbital, and lacosamide are the most frequently prescribed antiseizure medications for treatment of ESE. To date there are no class 1 data to support pharmacologic recommendations of one agent over another. We review each of these medications, their pharmacology, the scientific evidence in support and against each in the available literature, adverse effects and safety profiles, dosing recommendations, and limitations of the available evidence. We also discuss future directions including the established status epilepticus treatment trial (ESETT). Substantial further research is urgently needed to identify these patients (particularly those with non-convulsive status epilepticus), elucidate the most efficacious antiseizure treatment with head-to-head randomized prospective trials, and determine whether this differs for convulsive vs. non-convulsive ESE.

  13. Treatment of Established Status Epilepticus

    Science.gov (United States)

    Falco-Walter, Jessica J.; Bleck, Thomas

    2016-01-01

    Status epilepticus is the most severe form of epilepsy, with a high mortality rate and high health care costs. Status epilepticus is divided into four stages: early, established, refractory, and super-refractory. While initial treatment with benzodiazepines has become standard of care for early status epilepticus, treatment after benzodiazepine failure (established status epilepticus (ESE)) is incompletely studied. Effective treatment of ESE is critical as morbidity and mortality increases dramatically the longer convulsive status epilepticus persists. Phenytoin/fosphenytoin, valproic acid, levetiracetam, phenobarbital, and lacosamide are the most frequently prescribed antiseizure medications for treatment of ESE. To date there are no class 1 data to support pharmacologic recommendations of one agent over another. We review each of these medications, their pharmacology, the scientific evidence in support and against each in the available literature, adverse effects and safety profiles, dosing recommendations, and limitations of the available evidence. We also discuss future directions including the established status epilepticus treatment trial (ESETT). Substantial further research is urgently needed to identify these patients (particularly those with non-convulsive status epilepticus), elucidate the most efficacious antiseizure treatment with head-to-head randomized prospective trials, and determine whether this differs for convulsive vs. non-convulsive ESE. PMID:27120626

  14. Treatment of Convulsive Status Epilepticus.

    Science.gov (United States)

    Grover, Eric H; Nazzal, Yara; Hirsch, Lawrence J

    2016-03-01

    Convulsive status epilepticus (CSE) is a medical emergency with an associated high mortality and morbidity. It is defined as a convulsive seizure lasting more than 5 min or consecutive seizures without recovery of consciousness. Successful management of CSE depends on rapid administration of adequate doses of anti-epileptic drugs (AEDs). The exact choice of AED is less important than rapid treatment and early consideration of reversible etiologies. Current guidelines recommend the use of benzodiazepines (BNZ) as first-line treatment in CSE. Midazolam is effective and safe in the pre-hospital or home setting when administered intramuscularly (best evidence), buccally, or nasally (the latter two possibly faster acting than intramuscular (IM) but with lower levels of evidence). Regular use of home rescue medications such as nasal/buccal midazolam by patients and caregivers for prolonged seizures and seizure clusters may prevent SE, prevent emergency room visits, improve quality of life, and lower health care costs. Traditionally, phenytoin is the preferred second-line agent in treating CSE, but it is limited by hypotension, potential arrhythmias, allergies, drug interactions, and problems from extravasation. Intravenous valproate is an effective and safe alternative to phenytoin. Valproate is loaded intravenously rapidly and more safely than phenytoin, has broad-spectrum efficacy, and fewer acute side effects. Levetiracetam and lacosamide are well tolerated intravenous (IV) AEDs with fewer interactions, allergies, and contraindications, making them potentially attractive as second- or third-line agents in treating CSE. However, data are limited on their efficacy in CSE. Ketamine is probably effective in treating refractory CSE (RCSE), and may warrant earlier use; this requires further study. CSE should be treated aggressively and quickly, with confirmation of treatment success with epileptiform electroencephalographic (EEG), as a transition to non-convulsive status

  15. Current obesity drug treatment

    Directory of Open Access Journals (Sweden)

    Marcio C. Mancini

    2006-03-01

    Full Text Available Pharmacological treatment of obesity is an area of sudden changes,development of new drugs and treatment propositions. This articlepresents information on physiological agents that are currentlybeing used as well as drugs that were widely used but are nomore available.

  16. Current Treatments of Bruxism

    OpenAIRE

    Guaita, Marc; H?gl, Birgit

    2016-01-01

    Opinion statement Despite numerous case reports, the evidence for treatment of bruxism is still low. Different treatment modalities (behavioral techniques, intraoral devices, medications, and contingent electrical stimulation) have been applied. A clinical evaluation is needed to differentiate between awake bruxism and sleep bruxism and rule out any medical disorder or medication that could be behind its appearance (secondary bruxism). A polysomnography is required only in a few cases of slee...

  17. Current treatment of retinoblastoma

    International Nuclear Information System (INIS)

    Shields, J.A.

    1985-01-01

    Retinoblastoma is a highly malignant intraocular tumor of childhood which requires prompt treatment once the diagnosis has been established. The traditionally accepted methods include enucleation, external irradiation, scleral plaque irradiation, photocoagulation, cryotherapy, chemotherapy. This article will provide an update on the modern methods of treatment which are available for retinoblastoma. It is based largely on personal experience with approximately 200 new patients with retinoblastoma who were evaluated and treated between 1974 and 1984 in the Oncology Service of Wills Eye Hospital with an overall survival of 97%. This article will be an overall review which will not go into statistical detail. (Auth.)

  18. Current status of ion source development

    International Nuclear Information System (INIS)

    Ishikawa, Junzo

    2001-01-01

    In this report, the current status of ion source development will be discussed. In September 2001, the 9th International Conference on Ion Sources (ICIS01) was held in Oakland, U.S.A. Referring the talks presented at ICIS01, recent topics in the ion source research fields will be described. (author)

  19. Radiation processing. Current status and future possibilities

    International Nuclear Information System (INIS)

    Woods, R.J.

    2000-01-01

    Radiation processing developed following the Second World War and employees gamma- or electron-irradiation to process polymers, cure alkene-based inks and coatings, sterilize medical supplies, irradiate food, and manage wastes. The current status of these applications is described with the probable direction of future developments. (author)

  20. Current status of the AUSTRON project

    International Nuclear Information System (INIS)

    Rauch, H.; Regler, M.; Lechner, R.E.; Weber, H.

    2001-01-01

    The current status of the AUSTRON spallation source project is described with reference to the need for neutrons in Europe and - due to a certain West-East imbalance of large research facilities - especially in Central Europe. A short overview about technical aspects of proton accelerator, rapid cycling synchrotron, storage ring, target and instrumentation is presented. (author)

  1. ATM in Europe: analysis of current status

    DEFF Research Database (Denmark)

    1999-01-01

    This deliverable provides an overview of the current status of the European market for ATM services. The offer of ATM services by principal operators in Belgium, Denmark, Finland, France, Germany, Greece, Italy, Norway, Portugal, Spain, Sweden and United Kingdom is described. In addition, a number...... of international providers of ATM in Europe are presented....

  2. REMPAN at international level: current status

    International Nuclear Information System (INIS)

    Souchkevitch, Guennadi

    1997-01-01

    This document describes the current status of the Radiation Emergency medical Preparedness and Assistance Network - REMPAN, for the promotion of radiation emergency medical and public health preparedness and for practical assistance and advising countries, in a case of overexposure from any sources of radiation, by initiative of the World Health Organization - WHO

  3. Current status of methods for shielding analysis

    International Nuclear Information System (INIS)

    Engle, W.W.

    1980-01-01

    Current methods used in shielding analysis and recent improvements in those methods are discussed. The status of methods development is discussed based on needs cited at the 1977 International Conference on Reactor Shielding. Additional areas where methods development is needed are discussed

  4. [Current status on prevalence, treatment and management of hypertension among Chinese adults in the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases].

    Science.gov (United States)

    Jin, R R; Zhang, J; Li, J L; Li, J J; Ma, S; Bian, F; Deng, G J; Su, X W; Shen, Z Z; Wang, Y P; Jiang, Y

    2018-04-10

    Objective: To investigate the current status of prevalence, treatment, and management on hypertension among Chinese adults from the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases. Methods: We selected a total of 4 000 residents aged ≥18 years for this questionnaire-based survey by multi-stage clustering sampling in 10 National Demonstration Areas between November and December, 2016. Results: There were 3 891 effective questionnaires. The self-reported prevalence of hypertension among aged ≥35 years was 31.47% (1 011/3 213). For the past two weeks, the self-reported treatment of hypertension was 86.75%(877/1 011), with the rates of guidance as 56.87% (575/1 011) on physical activity, 40.95% (414/1 011) on diet, 38.33% (385/1 011) on weight management, and 22.75% (228/1 011) on smoking cessation. For the past 12 months, 74.68% (755/1 011) of the residents aged ≥35 years were under the proper management and 62.12% (628/1 011) of them were under the standardized management programs. The follow-up program lasted for 4 ( P(25) - P(75) : 4-12) times per year, with 15 ( P(25) - P(75) : 10-20) minutes per each visit. Hypertensive patients would mainly visit the outpatient clinics (53.51%), followed by home visits (22.91%) and telephone calls (13.64%). Rate of satisfaction on management services was 94.83% (716/755) from the hypertensive patients. Multivariate analysis showed that the rate of self-reported treatment ( OR =1.986, 95% CI : 1.222-3.228) and self-reported standardized management ( OR =2.204, 95% CI : 1.519-3.199) on hypertension were higher in the Demonstration Areas with higher implementation scores of self-reported non-communicable diseases management. Conclusions: Prevention and management on hypertension in the Demonstration Areas had met the requirement set for the Demonstration Areas during the "12th Five-Year Plan" . Projects on setting up the National Non-communicable Diseases Demonstration Areas

  5. Current status of quantum electrical metrology

    International Nuclear Information System (INIS)

    Urano, Chiharu; Kaneko, Nobuhisa; Kiryu, Shogo

    2005-01-01

    Physical background, current status of proof systems and researches of the next generation standards of Josephson voltage and Quantized Hall Resistance (QHR) standard system are described. Josephson effect, the principle and theory of quantized hall effect, usual voltage standard system, standard feed of direct current resistance, and researches of voltage standard and direct current resistance standard are explained. The current-voltage of Josephson element in the usual voltage standard proof system and bias method, outline of typical Josephson voltage standard proof system and GaAs/AlGaAs heterostructure used as resistance standard are stated. Cryogenic Current Comparator (CCC) and Direct Current Comparator (DCC) proofread usual resistor. New Quantum Hall Array Resistance Standard (QHARS) is studied by BNM-LNE group in French, and the other new AC Quantized Hall Resistance (AC-QHR) by the European ACQHE Project. (S.Y.)

  6. Current status of neutron scattering in Thailand

    International Nuclear Information System (INIS)

    Kornduangkaeo, Areeratt; Pongkasem, Somchai; Putchar, Suriya; Ampornrat, Pantip; Kajornrith, Varavuth; Chamchang, Jipawat

    2006-01-01

    The current neutron powder diffractometer at the Thai Research Reactor-1/Modification 1 (TRR-1/M1) has been modified from the obsolete neutron diffractometer which had been used during 1968-1975. The upgraded diffractometer has medium resolution and is appropriate for studying samples with small unit cell dimensions and training university students in the field of neutron scattering. This paper describes the current activities of neutron scattering research in Thailand, the current status of a new research reactor project at Ongkarak for enlarging the perspectives of its utilization in the future as well as the organizational reformation of the Office of Atomic Energy for Peace (OAEP). (author)

  7. Current status of theranostics in prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Virgolini, Irene; Decristoforo, Clemens; Uprimny, Christian [Medical University of Innsbruck, Department of Nuclear Medicine, Innsbruck (Austria); Haug, Alexander [Medical University of Vienna, Department of Radiology and Nuclear Medicine, Vienna (Austria); Fanti, Stefano [University of Bologna, S. Orsola Hospital Bologna, Nuclear Medicine Unit, Bologna (Italy)

    2018-03-15

    The aim of this review is to report on the current status of prostate-specific membrane antigen (PSMA)-directed theranostics in prostate cancer (PC) patients. The value of {sup 68}Ga-PSMA-directed PET imaging as a diagnostic procedure for primary and recurrent PC as well as the role of evolving PSMA radioligand therapy (PRLT) in castration-resistant (CR)PC is assessed. The most eminent data from mostly retrospective studies currently available on theranostics of prostate cancer are discussed. The current knowledge on {sup 68}Ga-PSMA PET/CT implicates that primary staging with PET/CT is meaningful in patients with high-risk PC and that the combination with pelvic multi parametric (mp)MR (or PET/mpMR) reaches the highest impact on patient management. There may be a place for {sup 68}Ga-PSMA PET/CT in intermediate-risk PC patients as well, however, only a few data are available at the moment. In secondary staging for local recurrence, {sup 68}Ga-PSMA PET/mpMR is superior to PET/CT, whereas for distant recurrence, PET/CT has equivalent results and is faster and cheaper compared to PET/mpMR. {sup 68}Ga-PSMA PET/CT is superior to {sup 18}F / {sup 11}Choline PET/CT in primary staging as well as in secondary staging. In patients with biochemical relapse, PET/CT positivity is directly associated with prostate-specific antigen (PSA) increase and amounts to roughly 50% when PSA is raised to ≤0.5 ng/ml and to ≥90% above 1 ng/ml. Significant clinical results have so far been achieved with the subsequent use of radiolabeled PSMA ligands in the treatment of CRPC. Accumulated activities of 30 to 50 GBq of {sup 177}Lu-PSMA ligands seem to be clinically safe with biochemical response and PERCIST/RECIST response in around 75% of patients along with xerostomia in 5-10% of patients as the only notable side effect. On the basis of the current literature, we conclude that PSMA-directed theranostics do have a major clinical impact in diagnosis and therapy of PC patients. We recommend

  8. Current status of low energy EB machine

    International Nuclear Information System (INIS)

    Toshiro Nishikimi; Shuichi Taniguchi; Kenichi Mizusawa

    1999-01-01

    Electron beam processing systems have been in use in a variety of applications such as curing of paints and printing inks, crosslinking of PE products, treating of rubber tire and so on. Low energy electron processing systems have become popular as self-shielded machines, which are compact and easy to use and do not require special facility as an irradiation room. This manuscript introduces the status of low energy EB (electron beam) machine through Nissin's products current

  9. Hepatitis B Virus Infection in Tanzania: Current Status and Challenges

    Science.gov (United States)

    Bakshi, Fatma A.; Jaka, Hyasinta

    2018-01-01

    Hepatitis B is one of the most common infectious diseases in the world with high prevalence in most of sub-Saharan Africa countries. The complexity in its diagnosis and treatment poses a significant management challenge in the resource-limited settings including Tanzania, where most of the tests and drugs are either unavailable or unaffordable. This mini review aims at demonstrating the current status of the disease in the country and discussing the concomitant challenges in diagnosis, treatment, and prevention. PMID:29666656

  10. Current status and installation of dental PACS

    International Nuclear Information System (INIS)

    Park, Chang Seo; Kim, Kee Deog; Park, Hyok; Jeong, Ho Gul

    2004-01-01

    Picture Archiving and Communication System (PACS) is difficult to implement in the best of situations, but evidence is growing that the benefits are significant. The aims of this study are to analyze the current status of full PACS and establish successful installation standard of dental PACS. Materials and Methods were based on the investigation of current working status and installation standard of PACS, and observation of variable issues to installation of dental PACS. By September 30, 2004, full PACS implementations in their facilities were 88.1% in specialized general hospitals (37 installations out of total 42 hospitals), 59.8% in general hospitals (144 installations out of total 241 hospitals), 12.3% in medical hospitals (116 installations out of total 941 hospitals) and 3.6% in dental hospitals (4 installations out of total 110 hospitals). Only 4 university dental hospitals currently have installed and are operating full PACS. Major obstacle to wide spread of dental PACS is initial high investments. Clinical environments of dental PACS differed from medical situation. Because of characteristic dental practice, the initial investments for dental PACS are generally much greater than those of medical PACS. Also new economic crisis makes users scruple. The best way to overcome these limitations is to establish an economic installation standard for dental PACS. Also the clear technical communication between the customer and the supplier before both sides are committed to the obstacles are critical to its success.

  11. Current status of neutron scattering in Thailand

    International Nuclear Information System (INIS)

    Ampornrat, Pantip

    2000-01-01

    The neutron scattering experiments in Thailand have been done continuously since the start up of the reactor. In 1977, Thai research reactor was modified into TRIGA MARK III core. After that, the neutron spectrometer was installed again under a development program. Installation of upgrading spectrometer was delayed because of some problems involving the neutron intensity and instruments. However, these problems were solved and the setup is almost completed. The paper reports the current status of neutron spectrometer, the problems and plans for the experiments. (author)

  12. Distal protection in cardiovascular medicine: current status.

    Science.gov (United States)

    Ali, Onn Akbar; Bhindi, Ravinay; McMahon, Aisling C; Brieger, David; Kritharides, Leonard; Lowe, Harry C

    2006-08-01

    Iatrogenic and spontaneous downstream microembolization of atheromatous material is increasingly recognized as a source of cardiovascular morbidity and mortality. Devising ways of reducing this distal embolization using a variety of mechanical means--distal protection--is currently under intense and diverse investigation. This review therefore summarizes the present status of distal protection. It examines the problem of distal embolization, describes the available distal protection devices, reviews those areas of cardiovascular medicine where distal protection devices are being investigated, and discusses potential future developments.

  13. Neutrino astronomy current status, future prospects

    CERN Document Server

    Karle, Albrecht

    2017-01-01

    This review volume is motivated by the recent discovery of high-energy astrophysical neutrinos by IceCube. The aim of the book is to bring together chapters on the status of current and future neutrino observatories with chapters on the implications and possible interpretations of the present observations and their upper limits. Each chapter is a mini-review of one aspect of the subject by leading experts. Taken together, the chapters constitute an up-to-date review of high-energy astrophysical neutrinos and their potential sources.

  14. [Current treatment of hepatic trauma].

    Science.gov (United States)

    Silvio-Estaba, Leonardo; Madrazo-González, Zoilo; Ramos-Rubio, Emilio

    2008-05-01

    The therapeutic and diagnostic approach of liver trauma injuries (by extension, of abdominal trauma) has evolved remarkably in the last decades. The current non-surgical treatment in the vast majority of liver injuries is supported by the accumulated experience and optimal results in the current series. It is considered that the non-surgical treatment of liver injuries has a current rate of success of 83-100%, with an associated morbidity of 5-42%. The haemodynamic stability of the patient will determine the applicability of the non-surgical treatment. Arteriography with angioembolisation constitutes a key technical tool in the context of liver trauma. Patients with haemodynamic instability will need an urgent operation and can benefit from abdominal packing techniques, damage control and post-operative arteriography. The present review attempts to contribute to the current, global and practical management in the care of liver trauma.

  15. The ENIQ pilot study: current status

    Energy Technology Data Exchange (ETDEWEB)

    Lemaitre, P; Eriksen, B; Crutzen, S [European Commission, DG Joint Research Centre, Petten (Netherlands); Hansch, M [Preussische Elektrizitaets-AG (Preussenelektra), Hannover (Germany); Whittle, J [AEA Technology, Warrington (United Kingdom)

    1998-11-01

    A pilot study is currently being carried out by ENIQ (European Network for Inspection Qualification) in order to explore the issues involved in inspection qualification applied along the general principles of the European methodology. The components selected for the pilot study are austenitic pipe to pipe and pipe to elbows welds typical of those in BWR recirculation loops. A range of defect parameters has been defined. A suitable inspection procedure designed to find the designated defects will be applied to geometrically representative test pieces. The procedure/equipment will be qualified through open trials and technical justification. The personnel qualification will be done in a blind way. Once all features of the inspection system will have been qualified an in-service inspection will be simulated in order to test the feasibility of the qualification approach followed. In this paper the current status of this pilot study is discussed. (orig.)

  16. Targeted alpha therapy: Applications and current status

    International Nuclear Information System (INIS)

    Bruchertseifer, Frank

    2017-01-01

    Full text: The field of targeted alpha therapy has been developed rapidly in the last decade. Besides 223 Ra, 211 At and 212 Pb/ 212 Bi the alpha emitters 225 Ac and 213 Bi are promising therapeutic radionuclides for application in targeted alpha therapy of cancer and infectious diseases. The presentation will give a short overview about the current clinical treatments with alpha emitting radionuclides and will place an emphasis on the most promising clinical testing of peptides and antibodies labelled with 225 Ac and 213 Bi for treatment of metastatic castration-resistant prostate cancer patients with glioma and glioblastoma multiform, PSMA-positive tumor phenotype and bladder carcinoma in situ. (author)

  17. IVS: Current Status and Future Plans

    Science.gov (United States)

    Behrend, D.; Nothnagel, A.; Petrachenko, W. T.; Tuccari, G.

    2016-12-01

    The International VLBI Service for Geodesy and Astrometry (IVS) is a globally operating service that coordinates and performs Very Long Baseline Interferometry (VLBI) activities through its constituent components. The VLBI activities are associated with the creation, provision, dissemination, and archiving of relevant VLBI data and products. The products mostly pertain to the determination of the celestial and terrestrial reference frames, the Earth orientation parameters (EOP), atmospheric parameters as well as other ancillary parameters. The IVS observational network currently consists of about 40 radio telescopes worldwide. Subsets of these telescopes (8-12 stations) participate in 24-hour observing sessions that are run several times per week and in 1-hour intensive sessions for UT1 determination every day. The current VLBI network was developed mainly in the 1970s and 1980s. A number of factors, including aging infrastructure and demanding new scientific requirements, started to challenge its future sustainability and relevance. In response, the IVS and other groups developed and started implementing the next generation VLBI system, called VGOS (VLBI Global Observing System), at existing and new sites. The VGOS network is expected to reach maturity in the early 2020s. We describe the current status, progress, and anticipated prospects of geodetic/astrometric VLBI and the IVS.

  18. Current status in Japan related to LMNPP

    International Nuclear Information System (INIS)

    Otsuka, Takehiro

    1998-01-01

    Current status of nuclear power plants in Japan is presented with the basic concepts against ageing of LWR plants which are considered to continue growing into the 21st century. Life management for aged NPPs is recognized to be important for the safe and reliable operation. In April 1996 MITI published the first report regarding the measures to cope with the aged NPPs. Two BWRs and one PWR were evaluated as aged NPPs in Phase-I Technical evaluation, which concluded that safe operation is possible with correct and adequate maintenance despite operation exceeded 30 years. The technology development items towards attaining further highly reliable management were indicated including the inspection/monitoring technology, the preventive maintenance/repair technology and ageing evaluation technology

  19. Current status of Pohang Neutron Facility

    Energy Technology Data Exchange (ETDEWEB)

    Kim, G.N.; Lee, Y.S.; Cho, M.H. [Pohang Accelerator Laboratory, POSTECH, Pohang (KR)] [and others

    2000-03-01

    We present the current status of Pohang Neutron Facility, which is the pulsed neutron facility, based on the 70-MeV electron linear accelerator completed on Dec.1997. We have prepared the 15-m time-of-flight path, a Ta-target system, and the Data Acquisition System. Meanwhile we have measured the total cross-sections of Dy and Hf samples at the Research Reactor Institute, Kyoto University and the neutron capture cross-sections of {sup 164}Dy isotope at Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology both in Japan. We also were participated the experiment at the 122-m flight path of the IBR-30 pulsed neutron source of Joint Institute of Nuclear Research in Dubna, Russia. (author)

  20. Current Status of Concentrator Photovoltaic (CPV) Technology

    Energy Technology Data Exchange (ETDEWEB)

    Philipps, Simon P. [Fraunhofer Inst. for Solar Energy Systems ISE, Freiburg (Germany); Bett, Andreas W. [Fraunhofer Inst. for Solar Energy Systems ISE, Freiburg (Germany); Horowitz, Kelsey [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kurtz, Sarah [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-12-01

    This report summarizes the status of the concentrator photovoltaic (CPV) market and industry as well as current trends in research and technology. This report is intended to guide research agendas for Fraunhofer ISE, the National Renewable Energy Laboratory (NREL), and other R&D organizations. Version 1.1 of this report includes recent progress in CPV. The recent record module efficiency of 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve.

  1. Hepatitis B Virus Infection in Tanzania: Current Status and Challenges

    OpenAIRE

    Kilonzo, Semvua B.; Gunda, Daniel W.; Mpondo, Bonaventura C. T.; Bakshi, Fatma A.; Jaka, Hyasinta

    2018-01-01

    Hepatitis B is one of the most common infectious diseases in the world with high prevalence in most of sub-Saharan Africa countries. The complexity in its diagnosis and treatment poses a significant management challenge in the resource-limited settings including Tanzania, where most of the tests and drugs are either unavailable or unaffordable. This mini review aims at demonstrating the current status of the disease in the country and discussing the concomitant challenges in diagnosis, treatm...

  2. Edible vaccines: Current status and future

    Directory of Open Access Journals (Sweden)

    Lal P

    2007-01-01

    Full Text Available Edible vaccines hold great promise as a cost-effective, easy-to-administer, easy-to-store, fail-safe and socioculturally readily acceptable vaccine delivery system, especially for the poor developing countries. It involves introduction of selected desired genes into plants and then inducing these altered plants to manufacture the encoded proteins. Introduced as a concept about a decade ago, it has become a reality today. A variety of delivery systems have been developed. Initially thought to be useful only for preventing infectious diseases, it has also found application in prevention of autoimmune diseases, birth control, cancer therapy, etc. Edible vaccines are currently being developed for a number of human and animal diseases. There is growing acceptance of transgenic crops in both industrial and developing countries. Resistance to genetically modified foods may affect the future of edible vaccines. They have passed the major hurdles in the path of an emerging vaccine technology. Various technical obstacles, regulatory and non-scientific challenges, though all seem surmountable, need to be overcome. This review attempts to discuss the current status and future of this new preventive modality.

  3. MDSplus integration at TCABR tokamak: Current status

    International Nuclear Information System (INIS)

    Sá, W.P. de; Ronchi, G.

    2016-01-01

    Highlights: • The implementation of MDSplus in TCABR tokamak, current status. • Interfaces between the system already installed and the MDSplus. • Web MDSplus interface. - Abstract: Experimental data for the TCABR tokamak is currently stored in MDSplus (Model Driven System Plus) database. The access to the data recorded during the experiments is performed using tools and libraries available by MDSplus system. The MDSplus system is widely used in different physics experiments, especially in plasmas physics and nuclear fusion. This standardized environment enables easy interaction among scientists of different experiments in different countries without the need to understand the particular characteristics of control, data acquisition and analysis, and remote access (CODAS) customized in each laboratory. In the first phase of implementation, intermediate interfaces had been developed between the legacy proprietary system and the MDSplus. In a second phase, the new diagnostic systems had been directly included in the created MDSplus system in the laboratory. After three years of use, the system installed on TCABR proved extremely efficient and significantly increased productivity in data analysis by involved scientists, regardless of whether they are locally at the TCABR, or accessing the system remotely from their home laboratories. The third phase, and subject of this article, are the development and implementation of the following systems: (i) web tools for the visualization of data, integrated with the experiment logbook, (ii) integration of MDSplus with applications (LabVIEW + MDSplus) and newer data acquisition hardware.

  4. MDSplus integration at TCABR tokamak: Current status

    Energy Technology Data Exchange (ETDEWEB)

    Sá, W.P. de, E-mail: pires@if.usp.br; Ronchi, G., E-mail: gronchi@if.usp.br

    2016-11-15

    Highlights: • The implementation of MDSplus in TCABR tokamak, current status. • Interfaces between the system already installed and the MDSplus. • Web MDSplus interface. - Abstract: Experimental data for the TCABR tokamak is currently stored in MDSplus (Model Driven System Plus) database. The access to the data recorded during the experiments is performed using tools and libraries available by MDSplus system. The MDSplus system is widely used in different physics experiments, especially in plasmas physics and nuclear fusion. This standardized environment enables easy interaction among scientists of different experiments in different countries without the need to understand the particular characteristics of control, data acquisition and analysis, and remote access (CODAS) customized in each laboratory. In the first phase of implementation, intermediate interfaces had been developed between the legacy proprietary system and the MDSplus. In a second phase, the new diagnostic systems had been directly included in the created MDSplus system in the laboratory. After three years of use, the system installed on TCABR proved extremely efficient and significantly increased productivity in data analysis by involved scientists, regardless of whether they are locally at the TCABR, or accessing the system remotely from their home laboratories. The third phase, and subject of this article, are the development and implementation of the following systems: (i) web tools for the visualization of data, integrated with the experiment logbook, (ii) integration of MDSplus with applications (LabVIEW + MDSplus) and newer data acquisition hardware.

  5. Current Status of Yongbyon Nuclear Complex

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Yong Soo [Korea Institute of Nuclear Non-proliferation and Control, Daejeon (Korea, Republic of)

    2016-05-15

    The DPRK has developed Yongbyon Nuclear Complex in Figure 1 since 1960's. Currently it is composed of the reactor facility, fuel fabrication facility including the enrichment center, and the radiochemistry center. Even though many facilities are not modern and economic in the western standards, Yongbyon Nuclear Complex is fully equipped with the entire life cycle of the nuclear installation. The key facilities have been added step by step. For example, the DPRK's nuclear reactor fleet started with the 2 MW IRT-2000 reactor in the middle of 80's. It started with a small scale radioactive isotope separation center nearby. But nowadays the DPRK is constructing a much more larger isotope separation center in the vicinity of its enrichment center along with a potential new UF6 conversion center. The general description over Yongbyon Nuclear Complex is given in this paper. More detailed context of the current status of the center will be discussed in the main symposium purely based on the open source information study.

  6. Radiotherapy in the curative treatment of breast cancer: current status and future trends. An opinion sample of radiation oncologists active in breast cancer research

    International Nuclear Information System (INIS)

    Kurtz, J.M.

    1994-01-01

    A questionnaire regarding the current practice of breast cancer radiotherapy and possible future trends in this field was filled out by 13 radiation oncologists active in breast cancer research. In the opinion of this small group, radiotherapy is presently included in the initial treatment of the large majority of early breast cancers, particularly in the framework of breast-conserving therapy, which is currently used in >50% of these patients. Indications for post-mastectomy irradiation vary greatly among respondents, as do attitudes toward the potentially negative aspects of adjuvant radiotherapy. Most respondents feel that their future practices will be significantly influenced by an increase in screen-detected cancers, the aging of the population, the increasing influence of medical oncologists, participation in clinical trials, and increased patient participation in treatment decisions. An increase is foreseen in the use of breast-conserving approaches, radiotherapy, and systemic therapies, and a decrease in the use of both total mastectomy and axillary dissection. Most respondents feel that there will be a modest decrease in the percentage of conservatively operated patients receiving radiotherapy. A future role is seen for neo-adjuvant chemotherapy, at least in well-defined subgroups, increasing the number of patients offered breast-conserving approaches. Most respondents expect that irradiation of lymph nodal areas will gain new credibility and be used more often. No majority opinion could be elicited regarding ways of improving the therapeutic ratio in breast cancer radiotherapy. (author)

  7. Current status of neutron capture therapy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-05-01

    There are about 6000 new glioblastoma multiform brain tumours diagnosed each year in the United States of America alone. This cancer is usually fatal within six months of diagnosis even with current standard treatments. Research on boron neutron capture therapy (BNCT) has been considered as a method of potentially curing such cancers. There is a great interest at under-utilised research reactors institutions to identify new medical utilization, attractive to the general public. Neutron capture therapy is a true multidisciplinary topic with a large variety of individuals involved. This publication attempts to provide current information for all those thinking about being involved with NCT, based on the knowledge and experience of those who have pioneered the treatment. It covers the whole range of NCT from designing reactor conversions or new facilities, through to clinical trials and their effectiveness. However, since most work has been done with boron capture therapy for brain tumours using modified thermal research reactors, this tends to be the focus of the report. One of the factors which need to be addressed at the beginning is the timing of the further development of NCT facilities. It should be emphasised that all current work is still at the research stage. Many of those now involved believe that there is little need for many more research facilities until such time as the treatment shows more promising results. For this and other reasons discussed in the report, very serious consideration should be given by research reactor owners and operators before spending large sums of money converting their facilities for NCT.

  8. Current status of neutron capture therapy

    International Nuclear Information System (INIS)

    2001-05-01

    There are about 6000 new glioblastoma multiform brain tumours diagnosed each year in the United States of America alone. This cancer is usually fatal within six months of diagnosis even with current standard treatments. Research on boron neutron capture therapy (BNCT) has been considered as a method of potentially curing such cancers. There is a great interest at under-utilised research reactors institutions to identify new medical utilization, attractive to the general public. Neutron capture therapy is a true multidisciplinary topic with a large variety of individuals involved. This publication attempts to provide current information for all those thinking about being involved with NCT, based on the knowledge and experience of those who have pioneered the treatment. It covers the whole range of NCT from designing reactor conversions or new facilities, through to clinical trials and their effectiveness. However, since most work has been done with boron capture therapy for brain tumours using modified thermal research reactors, this tends to be the focus of the report. One of the factors which need to be addressed at the beginning is the timing of the further development of NCT facilities. It should be emphasised that all current work is still at the research stage. Many of those now involved believe that there is little need for many more research facilities until such time as the treatment shows more promising results. For this and other reasons discussed in the report, very serious consideration should be given by research reactor owners and operators before spending large sums of money converting their facilities for NCT

  9. Targeted alpha therapy: Applications and current status

    Energy Technology Data Exchange (ETDEWEB)

    Bruchertseifer, Frank, E-mail: frank.bruchertseifer@ec.europa.eu [European Commission, Joint Research Centre, Karlsruhe (Germany)

    2017-07-01

    Full text: The field of targeted alpha therapy has been developed rapidly in the last decade. Besides {sup 223}Ra, {sup 211}At and {sup 212}Pb/{sup 212}Bi the alpha emitters {sup 225}Ac and {sup 213}Bi are promising therapeutic radionuclides for application in targeted alpha therapy of cancer and infectious diseases. The presentation will give a short overview about the current clinical treatments with alpha emitting radionuclides and will place an emphasis on the most promising clinical testing of peptides and antibodies labelled with {sup 225}Ac and {sup 213}Bi for treatment of metastatic castration-resistant prostate cancer patients with glioma and glioblastoma multiform, PSMA-positive tumor phenotype and bladder carcinoma in situ. (author)

  10. Endoscopic full-thickness resection: Current status.

    Science.gov (United States)

    Schmidt, Arthur; Meier, Benjamin; Caca, Karel

    2015-08-21

    Conventional endoscopic resection techniques such as endoscopic mucosal resection or endoscopic submucosal dissection are powerful tools for treatment of gastrointestinal neoplasms. However, those techniques are restricted to superficial layers of the gastrointestinal wall. Endoscopic full-thickness resection (EFTR) is an evolving technique, which is just about to enter clinical routine. It is not only a powerful tool for diagnostic tissue acquisition but also has the potential to spare surgical therapy in selected patients. This review will give an overview about current EFTR techniques and devices.

  11. [Current Treatment of Stable Angina].

    Science.gov (United States)

    Toggweiler, Stefan; Jamshidi, Peiman; Cuculi, Florim

    2015-06-17

    Current therapy for stable angina includes surgical and percutaneous revascularization, which has been improved tremendously over the last decades. Smoking cessation and regular exercise are the cornerstone for prevention of further cerebrovascular events. Medical treatment includes treatment of cardiovascular risk factors and antithrombotic management, which can be a challenge in some patients. Owing to the fact the coronary revascularization is readily accessible these days in many industrialized countries, the importance of antianginal therapy has decreased over the past years. This article presents a contemporary overview of the management of patients with stable angina in the year 2015.

  12. Hepatitis B Virus Infection in Tanzania: Current Status and Challenges

    Directory of Open Access Journals (Sweden)

    Semvua B. Kilonzo

    2018-01-01

    Full Text Available Hepatitis B is one of the most common infectious diseases in the world with high prevalence in most of sub-Saharan Africa countries. The complexity in its diagnosis and treatment poses a significant management challenge in the resource-limited settings including Tanzania, where most of the tests and drugs are either unavailable or unaffordable. This mini review aims at demonstrating the current status of the disease in the country and discussing the concomitant challenges in diagnosis, treatment, and prevention.

  13. Current status of relativistic core collapse simulations

    Energy Technology Data Exchange (ETDEWEB)

    Font, Jose A [Departamento de Astronomia y Astrofisica, Universidad de Valencia, Dr. Moliner 50, 46100 Burjassot (Valencia) (Spain)

    2007-05-15

    With the first generation of ground-based gravitational wave laser interferometers already taking data, the availability of reliable waveform templates from astrophysical sources, which may help extract the signal from the anticipated noisy data, is urgently required. Gravitational stellar core collapse supernova has traditionally been considered among the most important astrophysical sources of potentially detectable gravitational radiation. Only very recently the first multidimensional simulations of relativistic rotational core collapse have been possible (albeit for models with simplified input physics), thanks to the use of conservative formulations of the hydrodynamics equations and advanced numerical methodology, as well as stable formulations of Einstein's equations. In this paper, the current status of relativistic core collapse simulations is discussed, with the emphasis given to the modelling of the collapse dynamics and to the computation of the gravitational radiation in the existing numerical approaches. Work employing the conformally-flat approximation (CFC) of the 3+1 Einstein's equations is reported, as well as extensions of this approximation (CFC+) and investigations within the framework of the so-called BSSN formulation of the 3+1 gravitational field equations (with no approximation for the spacetime dynamics). On the other hand, the incorporation of magnetic fields and the MHD equations in numerical codes to improve the realism of core collapse simulations in general relativity, is currently an emerging field where significant progress is bound to be soon achieved. The paper also contains a brief discussion of magneto-rotational simulations of core collapse, aiming at addressing the effects of magnetic fields on the collapse dynamics and on the gravitational waveforms.

  14. Current status of relativistic core collapse simulations

    International Nuclear Information System (INIS)

    Font, Jose A

    2007-01-01

    With the first generation of ground-based gravitational wave laser interferometers already taking data, the availability of reliable waveform templates from astrophysical sources, which may help extract the signal from the anticipated noisy data, is urgently required. Gravitational stellar core collapse supernova has traditionally been considered among the most important astrophysical sources of potentially detectable gravitational radiation. Only very recently the first multidimensional simulations of relativistic rotational core collapse have been possible (albeit for models with simplified input physics), thanks to the use of conservative formulations of the hydrodynamics equations and advanced numerical methodology, as well as stable formulations of Einstein's equations. In this paper, the current status of relativistic core collapse simulations is discussed, with the emphasis given to the modelling of the collapse dynamics and to the computation of the gravitational radiation in the existing numerical approaches. Work employing the conformally-flat approximation (CFC) of the 3+1 Einstein's equations is reported, as well as extensions of this approximation (CFC+) and investigations within the framework of the so-called BSSN formulation of the 3+1 gravitational field equations (with no approximation for the spacetime dynamics). On the other hand, the incorporation of magnetic fields and the MHD equations in numerical codes to improve the realism of core collapse simulations in general relativity, is currently an emerging field where significant progress is bound to be soon achieved. The paper also contains a brief discussion of magneto-rotational simulations of core collapse, aiming at addressing the effects of magnetic fields on the collapse dynamics and on the gravitational waveforms

  15. Radiopharmaceuticals in China. Current status and prospects

    Energy Technology Data Exchange (ETDEWEB)

    Jia, Hong-Mei; Liu, Bo-Li [Beijing Normal Univ. (China). Key Laboratory of Radiopharmaceuticals

    2014-04-01

    The review provides an overview of the current status of radiopharmaceuticals in China for in vivo clinical use and also describes some important advances in the past three decades. Development of the diagnostic and therapeutic radiopharmaceuticals as well as basic research on radiopharmaceutical chemistry are being introduced. The radiotracers developed in China include: (1) Brain perfusion imaging agents and CNS radiotracers for β-amyloid plaques, σ{sub 1} receptors, and dopamine D{sub 2} or D{sub 4} receptors; (2) {sup 99m}Tc- and {sup 18}F-labeled myocardial perfusion imaging agents; (3) tumor imaging agents including integrin-targeting radiotracer, novel sentinel lymph node imaging agents, hypoxia imaging agents, {sup 99m}Tc-labeled glucose derivatives, σ{sub 2} receptor imaging agents, folate receptor imaging agents, and potential radiotracers for imaging of human telomerase reverse transcriptase expression; (4) Potential infection imaging agents; (5) Potential asialoglycoprotein receptor imaging agents; (6) Other imaging agents. Moreover, some prospects of research and development of radiopharmaceuticals in the near future are discussed. (orig.)

  16. Current status of GALS setup in JINR

    Energy Technology Data Exchange (ETDEWEB)

    Zemlyanoy, S., E-mail: zemlya@jinr.ru; Avvakumov, K., E-mail: kavvakumov@jinr.ru [Joint Institute for Nuclear Research, Flerov Laboratory of Nuclear Reactions (Russian Federation); Fedosseev, V. [CERN (Switzerland); Bark, R. [Nat. Research Foundation, iThemba LABS (South Africa); Blazczak, Z. [A. Mickiewicz University, Faculty of Physics (Poland); Janas, Z. [University of Warsaw, Faculty of Physics (Poland)

    2017-11-15

    This is a brief report on the current status of the new GAs cell based Laser ionization Setup (GALS) at the Flerov Laboratory for Nuclear Reactions (FLNR) of the Joint Institute for Nuclear Research (JINR) in Dubna. GALS will exploit available beams from the U-400M cyclotron in low energy multi-nucleon transfer reactions to study exotic neutron-rich nuclei located in the “north-east” region of nuclear map. Products from 4.5 to 9 MeV/nucleon heavy-ion collisions, such as {sup 136}Xe on {sup 208}Pb, are thermalized and neutralized in a high pressure gas cell and subsequently selectively laser re-ionized. In order to choose the best scheme of ion extraction the results of computer simulations of two different systems are presented. The first off- and online experiment will be performed on osmium atoms that is regarded as a most convenient element for producing isotopes with neutron number in the vicinity of the magic N = 126.

  17. The Japanese artificial organs scene: current status.

    Science.gov (United States)

    Mitamura, Yoshinori; Murabayashi, Shun

    2005-08-01

    Artificial organs and regenerative medicine are the subjects of very active research and development (R&D) in Japan and various artificial organs are widely used in patients. Results of the R&D are presented at the annual conference of the Japanese Society for Artificial Organs (JSAO). Progress in the fields of artificial organs and regenerative medicine are reviewed annually in the Japanese Journal of Artificial Organs. The official English-language journal of JSAO, Journal of Artificial Organs, also publishes many original articles by Japanese researchers. Although the annual conference and the publications of JSAO provide the world with update information on artificial organs and regenerative medicine in Japan, the information is not always understood appropriately in the rest of the world, mainly due to language problems. This article therefore introduces the current status of artificial organs and regenerative medicine in Japan. Artificial hearts and metabolic support systems are reviewed here and other interesting areas such as regenerative medicine can be found elsewhere.

  18. Current status of chirality in agrochemicals.

    Science.gov (United States)

    Jeschke, Peter

    2018-04-27

    The agrochemical industry is continuously searching for new pesticides to develop products with optimal efficacy, lower application rates in the field, increased selectivity, favorable toxicological and environmental safety, enhanced user friendliness and better economic viability. One strategy to achieve these ambitious goals makes use of the unique properties of molecules containing asymmetric centers. In the past, many natural products and their congeners have been a source of inspiration for designing new active ingredients, and the molecular structure of the resulting molecules have become increasingly complex. 30% contain fragments with asymmetric centers. However, despite the enormous progress that has been made in catalytic asymmetric processes over the last decade, only few agrochemicals are produced in enantiomerically pure or enriched form on an industrial scale. Since 2007, around 43% of the 44 launched products (insecticides, acaricides, fungicides, nematicides, and herbicides) contain one or more asymmetric centers in the molecule (≈ 47 %) and most of them were launched as racemic mixtures of enantiomers or diastereomers. This review gives an overview of the current status of chiral agrochemicals launched over the past 10 years and describes the inherently connected challenges of modern agricultural chemistry by managing important aspects resulting from stereochemistry of these innovative products. This article is protected by copyright. All rights reserved.

  19. Current Status of TRR-1/M1

    International Nuclear Information System (INIS)

    Sittichai, Chaiyut

    2000-01-01

    In 1961, the first Thai Research Reactor, TRR-1, having power of 1 MW was established. It was located at Office of Atomic Energy for Peace (OAEP) in Bangkok. TRR-1 was completely commissioned in June 1962. Plate typed high-enriched uranium (HEU) and U 3 O 8 -Al were used as fuel. Light water used as moderator and coolant. During 1975-1977, TRR-1 was shut down for modification. The reactor core and control system were disassembled and replaced by TRIGA Mark III. It is a circular hexagonal core typed reactor designed by General Atomics Company (GA). Afterwards, TRR-1 was officially renamed to Thai Research Reactor 1/Modification 1 (TRR-1/M1). TRR-1/M1 is a multipurpose reactor with nominal power of 2 MW. This swimming pool typed reactor uses low-enriched uranium (LEU) as fuel and light water as coolant and moderator. To date, the reactor has been operated with core No.12 that released power 1135 MWD to serve the user. The reactor has been serving for various kinds of utilization, for example, to produce radioisotope, neutron beam experiments and reactor physics experiments. This report explains in detail regarding operational experience and current status of this reactor, for example, reactor operation and reactor utilization. (author)

  20. Current status of construction license of PEFP

    International Nuclear Information System (INIS)

    Kim, J. Y.; Cho, J. S.; Min, Y. S.; Nam, J. M.; Jeon, G. P.; Park, S. S.; Jo, J. H.; Song, I. T.

    2012-01-01

    Since 2010 August, PEFP(Proton Engineering Frontier Project)'s Proton Accelerator Research Center has been under construction so far. Generally, in advance of construction startup, many kinds of licenses should be acquired along with the types of construction works. To acquire a license in time, each item should meet the standard by the related regulation, including not only procedural but also content aspect. In the advent of internet era, electronic government system has been adopted in many governmental functions: So is the national construction license acquisition system. Owing to the system, both approval and documentation functions in licensing are integrated in online computer network which provide us simplification in process and easy accessibility to license data. However, aside from these construction licenses, other types of licenses still remain separately managed: Machinery, electric facilities, and so on. Moreover, all the licenses have the priority order and take legal term in processing. So, to avoid any time delay in license acquisition, we organized license hierarchy and found out the priority among them. Thereafter, according to their legal term in approval and acquisition, whole license acquisition schedule was arranged and we completed all the necessary licenses acquisition in time In this study, we summarize the current status of license acquisition on Proton Accelerator Research Center Construction, and manifest how they have been and will be managed systematically

  1. Current status of construction license of PEFP

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. Y.; Cho, J. S.; Min, Y. S.; Nam, J. M.; Jeon, G. P.; Park, S. S.; Jo, J. H.; Song, I. T. [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    Since 2010 August, PEFP(Proton Engineering Frontier Project)'s Proton Accelerator Research Center has been under construction so far. Generally, in advance of construction startup, many kinds of licenses should be acquired along with the types of construction works. To acquire a license in time, each item should meet the standard by the related regulation, including not only procedural but also content aspect. In the advent of internet era, electronic government system has been adopted in many governmental functions: So is the national construction license acquisition system. Owing to the system, both approval and documentation functions in licensing are integrated in online computer network which provide us simplification in process and easy accessibility to license data. However, aside from these construction licenses, other types of licenses still remain separately managed: Machinery, electric facilities, and so on. Moreover, all the licenses have the priority order and take legal term in processing. So, to avoid any time delay in license acquisition, we organized license hierarchy and found out the priority among them. Thereafter, according to their legal term in approval and acquisition, whole license acquisition schedule was arranged and we completed all the necessary licenses acquisition in time In this study, we summarize the current status of license acquisition on Proton Accelerator Research Center Construction, and manifest how they have been and will be managed systematically.

  2. Current status of JENDL-3.3

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Akira [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-03-01

    Current status of JENDL-3.3 is presented. Reevaluation work toward JENDL-3.3 has started last April for three years project to supply a consolidated new versions of JENDL by JAERI NDC (Nuclear Data center) with the cooperation of JNDC (Japanese Nuclear Data Committee). The working schedule has been fixed by the careful review of the summary report, `The problems of JENDL-3.2`, submitted to JNDC last March after one year discussions by a small advisory group: `Identifying the problems of JENDL-3.2`. To cope with the problems, two new subgroups are set up in the Subcommittee of Nuclear Data of JNDC. One is Heavy Mass Elements Evaluation Working Group for the re-evaluation of major actinides (Th-232, U-233,235,236,238, Pu-236,239,241,242). The other is Intermediate Mass Elements Evaluation Working Group for solving the inconsistencies between calculations and integral experiments relating to the fields of fusion neutronics and shielding applications as well as new evaluations such as Er elements. Supplying covariance data for important nuclides are one of the main feature of JENDL-3.3. Re-evaluated data will be released as JENDL-3.3 in the individual bases after the reviewing process by the experts. (author)

  3. Current status of ITER EC design

    International Nuclear Information System (INIS)

    Bosia, G.

    2003-01-01

    The ITER-FEAT Electron Cyclotron System employs one equatorial launcher and three upper port launchers to inject 20 + 20 MW of mm-wave power at 170 GHz through slots in the plasma-facing neutron and radiation shield. The equatorial launcher includes 3 sets of toroidally steer-able mirrors, each collecting 8 RF beams from 24 circular cross-section corrugated wave-guides. In the upper-port launcher, eight beams, reflected in pairs by four toroidally angled (∼30 angle) and poloidally steer-able (∼ 10 angle) mirrors focus of the RF power on the plasma m = 2 and m = 3/2 plasma flux rational surfaces, for neo-classical tearing mode(s) (NTM) control. Conceptual studies of remote steering that would possibly allow removing the beam- steering equipment from the vacuum vessel and locating them in more protected positions have been carried out. All EC wave transmission is based on low losses circular cross section corrugated and evacuated wave guides each connected to a 170 GHz, 1 MW CW Gyrotron tube oscillator featuring an overall efficiency of ∼ 50%, obtained by depressed-collector energy recovery. In the paper, requirements, issues and the current status of the design is reviewed. (authors)

  4. IAEA occupational radiation protection programme: current status

    International Nuclear Information System (INIS)

    Deboodt, P.; Mrabit, K.

    2006-01-01

    As stated in Art.III.A.6 of its Statute, the International Atomic Energy Agency (commonly referred to as the Agency) is authorized to establish or adopt, in consultation and, where appropriate, in collaboration with the competent organs of the United Nations and with the specialized agencies concerned, standards of safety for protection of health and minimization of danger to life and property (including such standards for labour conditions), and to provide for the application of these standards to its own operation as well as to the operations making use of materials, services, equipment, facilities, and information made available by the Agency or at its request or under its control or supervision. The Agency s Occupational Radiation Protection Programme aims at harmonizing infrastructures for the control of radiation exposure of workers and for optimizing radiation protection in situation s of exposures due to external radiation and intakes of radionuclides from both artificial and natural sources of radiation. Under its regular and technical cooperation programmes, the Agency has been assigning high priority to both the establishment of safety standards for labour conditions and for the application of these standards through, Interalia, direct assistance under its technical cooperation (TC) programme, the rendering of services, the promotion of education and training, the fostering of information exchange and the coordination of research and development. The purpose of this paper is to present the current status and future IAEA activities in support of occupational radiation protection. (authors)

  5. Current status of the IREN project

    International Nuclear Information System (INIS)

    Furman, W.I.

    1997-01-01

    A current status and a corrected time-schedule of the project of the new Intense Resonance Neutron pulsed source (IREN) realized in JINR (Dubna) for experiments dealing with fundamental and applied nuclear physics studies are discussed. This source is the upgraded variant of the existing IBR-30 pulsed booster. It consists of the 200 MeV electron linac and supplying by an electron beam the photo-neutron converter placed in the center of the very fast multiplying subcritical core. The existing buildings and beam infrastructure are planned to adopt for the new IREN source. The aim of the project is to improve essentially an energy resolution of the time-of-flight spectrometer and to increase twice (up to 10 15 n/sec) an integral neutron yield. An implementation of the IREN project has started in June 1994 with the planned end in December 1997. But due to mainly insufficient financing the approved time-schedule is shifted. Now most optimistic time of start-up of the neutron source is the end of 1999

  6. Current status of research on school refusal

    Directory of Open Access Journals (Sweden)

    Cándido J. Inglés

    2015-06-01

    Full Text Available School refusal behavior refers to the avoidance of a child attending school and/or persistent difficulty staying in the classroom throughout the school day. Based on a review of the scientific literature, the aim of this study is to describe the current state of research on school refusal, differentiating between the findings and progress made in Spain from those achieved in the international field. For this purpose, the significance of this phenomenon, in addition to associated risk factors and variables, will be reviewed in the child and youth population. In turn, the commonly used assessment methods and most recommended treatment proposals, mainly based on cognitive behavioral therapy, are discussed. The results reveal several gaps and subjects for debate in some areas of knowledge about school refusal behavior, with differences being found between Spanish and international studies. In conclusion, future studies and challenges in this field are required.

  7. Current Status of Renal Denervation in Hypertension.

    Science.gov (United States)

    Briasoulis, Alexander; Bakris, George L

    2016-11-01

    Over the past 7 years, prospective cohorts and small randomized controlled studies showed that renal denervation therapy (RDN) in patients with resistant hypertension is safe but associated with variable effects on BP which are not substantially better than medical therapy alone. The failure of the most rigorously designed randomized sham-control study, SYMPLICITY HTN-3, to meet the efficacy endpoints has raised several methodological concerns. However, recently reported studies and ongoing trials with improved procedural characteristics, identification of patients with true treatment-resistant hypertension on appropriate antihypertensive regimens further explore potential benefits of RDN. The scope of this review is to summarize evidence from currently completed studies on RDN and discuss future perspectives of RDN therapy in patients with resistant hypertension.

  8. Molecular imaging: current status and emerging strategies

    International Nuclear Information System (INIS)

    Pysz, M.A.; Gambhir, S.S.; Willmann, J.K.

    2010-01-01

    In vivo molecular imaging has a great potential to impact medicine by detecting diseases in early stages (screening), identifying extent of disease, selecting disease- and patient-specific treatment (personalized medicine), applying a directed or targeted therapy, and measuring molecular-specific effects of treatment. Current clinical molecular imaging approaches primarily use positron-emission tomography (PET) or single photon-emission computed tomography (SPECT)-based techniques. In ongoing preclinical research, novel molecular targets of different diseases are identified and, sophisticated and multifunctional contrast agents for imaging these molecular targets are developed along with new technologies and instrumentation for multi-modality molecular imaging. Contrast-enhanced molecular ultrasound (US) with molecularly-targeted contrast microbubbles is explored as a clinically translatable molecular imaging strategy for screening, diagnosing, and monitoring diseases at the molecular level. Optical imaging with fluorescent molecular probes and US imaging with molecularly-targeted microbubbles are attractive strategies as they provide real-time imaging, are relatively inexpensive, produce images with high spatial resolution, and do not involve exposure to ionizing irradiation. Raman spectroscopy/microscopy has emerged as a molecular optical imaging strategy for ultrasensitive detection of multiple biomolecules/biochemicals with both in vivo and ex vivo versatility. Photoacoustic imaging is a hybrid of optical and US techniques involving optically-excitable molecularly-targeted contrast agents and quantitative detection of resulting oscillatory contrast agent movement with US. Current preclinical findings and advances in instrumentation, such as endoscopes and microcatheters, suggest that these molecular imaging methods have numerous potential clinical applications and will be translated into clinical use in the near future.

  9. Current status of JMTR refurbishment project

    International Nuclear Information System (INIS)

    Kaminaga, Masanori; Niimi, Motoji; Hori, Naohiko; Takahashi, Kunihiro; Kanno, Masaru; Nakagawa, Tetsuya; Nagao, Yoshiharu; Ishihara, Masahiro; Kawamura, Hiroshi

    2010-02-01

    The JMTR is a light water moderated and cooled, beryllium reflected tank- type reactor using LUE silicide plate-type fuels. Its thermal power is 50 MW, maximum thermal and fast neutron flux is 4x10 18 m -2 s -1 . First criticality was achieved in March 1968, and its operation was stopped from August, 2006 for the refurbishment. The refurbishment is scheduled from the beginning of FY2007 to the end of FY2010. The renewed and upgraded JMTR will be re-started from FY2011. An investigation on aged components (aged-investigation) was carried out for concrete structures of the JMTR reactor building, exhaust stack, etc., and for tanks in the primary cooling system, heat exchangers, pipes in the secondary cooling system, cooling tower, emergency generators and so on, in order to identify their integrity. The aged-investigation was carried out at the beginning of FY2007. As a result, some components were decided to replace from viewpoints of future maintenance and improvement of reliability, and some components or structures were decided to repair. A visual inspection of inner side of the pressure vessel was carried out using an underwater camera in FY2008, and no serious damage was observed. Up to now, refurbishment works are in progress according to the planned schedule. In FY2009, motors of primary cooling pumps, secondary cooling pumps, motors of drain pumps, pump in the primary water transfer line to the water purification system, beryllium reflector frame, low-voltage motor control centers are to be replaced. A nuclear instrumentation system, process control system, safety protection system and so on are to be replaced in FY2010. In this paper, current status of JMTR refurbishment project is presented. (author)

  10. Current status of NPP generation IV

    International Nuclear Information System (INIS)

    Yohanes Dwi Anggoro; Dharu Dewi; Nurlaila; Arief Tris Yuliyanto

    2013-01-01

    Today development of nuclear technology has reached the stage of research and development of Generation IV nuclear power plants (advanced reactor systems) which is an innovative development from the previous generation of nuclear power plants. There are six types of power generation IV reactors, namely: Very High Temperature Reactor (VHTR), Sodium-cooled Fast Reactor (SFR), Gas-cooled Fast Reactor (GFR), Lead-cooled Fast Reactor (LFR), Molten Salt Reactor (MSR), and Super Critical Water-cooled Reactor (SCWR). The purpose of this study is to know the development of Generation IV nuclear power plants that have been done by the thirteen countries that are members of the Gen IV International Forum (GIF). The method used is review study and refers to various studies related to the current status of research and development of generation IV nuclear power. The result of this study showed that the systems and technology on Generation IV nuclear power plants offer significant advances in sustainability, safety and reliability, economics, and proliferation resistance and physical protection. In addition, based on the research and development experience is estimated that: SFR can be used optimally in 2015, VHTR in 2020, while NPP types GFR, LFR, MSR, and SCWR in 2025. Utilization of NPP generation IV said to be optimal if fulfill the goal of NPP generation IV, such as: capable to generate energy sustainability and promote long-term availability of nuclear fuel, minimize nuclear waste and reduce the long term stewardship burden, has an advantage in the field of safety and reliability compared to the previous generation of NPP and VHTR technology have a good prospects in Indonesia. (author)

  11. [Current status of noninvasive hemodynamics in hypertension].

    Science.gov (United States)

    Waisman, G

    Hypertension is a haemodynamic disorder resulting from a persistent mismatch between cardiac output and peripheral resistance. Hypertension undergoes haemodynamic progression during its natural history. Impedance cardiography is a method of evaluating the cardiovascular system that obtains haemodynamic information from beat to beat through the analysis of variations in the impedance of the thorax on the passage of an electric current. Impedance cardiography unmasks the haemodynamic deterioration underlying the increase in blood pressure as age and systolic blood pressure increases. This method may help to improve blood pressure control through individualized treatment with reduction of peripheral resistance, maintenance of cardiac output or its increase, improvement of arterial compliance and preservation of organ-tissue perfusion. It is useful in the management of patients with resistant hypertension, since a greater percentage of patients controlled with changes in the treatment in relation to the haemodynamic measurements are obtained. Impedance cardiography is important and has prognostic utility in relation to a haemodynamic deterioration pattern and increased cardiovascular events. Copyright © 2017 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.

  12. Sagebrush ecosystems: current status and trends.

    Science.gov (United States)

    Beever, E.A.; Connelly, J.W.; Knick, S.T.; Schroeder, M.A.; Stiver, S. J.

    2004-01-01

    The sagebrush (Artemisia spp.) biome has changed since settlement by Europeans. The current distribution, composition and dynamics, and disturbance regimes of sagebrush ecosystems have been altered by interactions among disturbance, land use, and invasion of exotic plants. In this chapter, we present the dominant factors that have influenced habitats across the sagebrush biome. Using a large-scale analysis, we identified regional changes and patterns in “natural disturbance”, invasive exotic species, and influences of land use in sagebrush systems. Number of fires and total area burned has increased since 1980 across much of the sagebrush biome. Juniper (Juniperus spp.) and pinyon (Pinus spp.) woodlands have expanded into sagebrush habitats at higher elevations. Cheatgrass (Bromus tectorum), an exotic annual grass, has invaded much of lower elevation, more xeric sagebrush landscapes across the western portion of the biome. Consequently, synergistic feedbacks between habitats and disturbance (natural and human-caused) have altered disturbance regimes, plant community dynamics and contributed to loss of sagebrush habitats and change in plant communities. Habitat conversion to agriculture has occurred in the highly productive regions of the sagebrush biome and influenced up to 56% of the Conservation Assessment area. Similarly, urban areas, and road, railroad, and powerline networks fragment habitats, facilitate predator movements, and provide corridors for spread of exotic species across the entire sagebrush biome. Livestock grazing has altered sagebrush habitats; the effects of overgrazing combined with drought on plant communities in the late 1880s and early 1900s still influences current habitats. Management of livestock grazing has influenced sagebrush ecosystems by habitat treatments to increase forage and reduce sagebrush and other plant species unpalatable to livestock. Fences, roads, and water developments to manage livestock movements have further

  13. Current treatments for radiation retinopathy

    Energy Technology Data Exchange (ETDEWEB)

    Giuliari, Gian Paolo; Simpson, E. Rand (Princess Margaret Hospital, Univ. of Toronto, Dept. of Ophthalmology and Vision Sciences, Toronto (Canada)), e-mail: gpgiuliari@gmail.com; Sadaka, Ama (Schepens Eye Research Inst., Boston, MA (United States)); Hinkle, David M. (Massachusetts Eye Research and Surgery Institution, Cambridge, MA (United States))

    2011-01-15

    Background. To review the currently available therapeutic modalities for radiation retinopathy (RR), including newer investigational interventions directed towards specific aspects of the pathophysiology of this refractory complication. Methods. A review of the literature encompassing the pathogenesis of RR and the current therapeutic modalities available was performed. Results. RR is a chronic and progressive condition that results from exposure to any source of radiation. It might be secondary to radiation treatment of intraocular tumors such as choroidal melanomas, retinoblastomas, and choroidal metastasis, or from unavoidable exposure to excessive radiation from the treatment of extraocular tumors like cephalic, nasopharyngeal, orbital, and paranasal malignancies. After the results of the Collaborative Ocular Melanoma Study, most of the choroidal melanomas are being treated with plaque brachytherapy increasing by that the incidence of this radiation complication. RR has been reported to occur in as many as 60% of eyes treated with plaque radiation, with higher rates associated with larger tumors. Initially, the condition manifests as a radiation vasculopathy clinically seen as microaneurysms and telangiectasis, with posterior development of retinal hard exudates and hemorrhages, macular edema, neovascularization and tractional retinal detachment. Regrettably, the management of these eyes remains limited. Photodynamic therapy, laser photocoagulation, oral pentoxyphylline and hyperbaric oxygen have been attempted as treatment modalities with inconclusive results. Intravitreal injections of anti-vascular endothelial growth factor such as bevacizumab, ranibizumab and pegaptanib sodium have been recently used, also with variable results. Discussion. RR is a common vision threatening complication following radiation therapy. The available therapeutic options are limited and show unsatisfactory results. Further large investigative studies are required for developing

  14. Current status of Uganda Kob (Kobus Kob Thomasi Neumann) in ...

    African Journals Online (AJOL)

    Current status of Uganda Kob (Kobus Kob Thomasi Neumann) in Toro Game Reserve, Uganda. ... As part of a biological assessment of Toro Game Reserve, the status of Uganda kob Kobus kob Thomasi ... AJOL African Journals Online.

  15. [Immunotherapy for renal cell carcinoma - current status].

    Science.gov (United States)

    Grimm, Marc-Oliver; Foller, Susan

    2018-04-01

    Systemic treatment of metastatic renal cell carcinoma (mRCC) has substantially changed during the last 2 years due to approval of the immune-checkpoint inhibitor Nivolumab (Opdivo ® ) and new multikinase inhibitors (Cabozantinib, Lenvatinib, Tivozanib). The german kidney tumor guideline strongly recommends Nivolumab and Cabozantinib as 2nd line treatments after prior VEGF targeted therapy. CheckMate 025, the prospective randomized trial which led to approval of Nivolumab demonstrated improved overall survival (26 month vs. 19.7 month; hazard ratio 0.73; p = 0.0006) and response rate (26 % vs. 5 %) as well as a favorable toxicity profile compared with Everolimus. Currently, numerous combinations with PD-1/PD-L1 inhibitors are compared to Sunitinib as first line treatment of mRCC. Out of these CheckMate 214, a randomized phase-3 trial is the first to demonstrate a significant higher objective response rate (42 % vs. 27 %, p < 0.0001) and overall survival (Sunitinib 26.0 month, median for Nivo + Ipi has been not yet reached (28.2 - NR); Hazard ratio 0.63) for the combination of Nivolumab and the CTLA-4 antibody Ipilimumab in IMDC intermediate and high risk patients. Furthermore, CheckMate 214 shows better side effect profile and quality of life in patients receiving Nivolumab and Ipilimumab compared with Sunitinib. However, a considerable increase of immune related adverse events is associated with the immune combination therapy. Another randomized trial demonstrates improved progression-free survival for the combination of the PD-L1 inhibitor Atezolizumab and the VEGF antibody Bevacizumab in patients with PD-L1 positive tumors; this was found in all IMDC risk groups. Further phase-3 trials with "new" VEGFR-TKIs (Axitinib, Cabozantinib, Lenvatinib) and PD-1/PD-L1 inhibitor combinations are ongoing.In conclusion, the PD-1 immune checkpoint inhibitor Nivolumab will remain a standard treatment for patients with metastatic renal cell carcinoma

  16. Current Challenges in Cancer Treatment.

    Science.gov (United States)

    Zugazagoitia, Jon; Guedes, Cristiano; Ponce, Santiago; Ferrer, Irene; Molina-Pinelo, Sonia; Paz-Ares, Luis

    2016-07-01

    In this review, we highlight the current concepts and discuss some of the current challenges and future prospects in cancer therapy. We frequently use the example of lung cancer. We conducted a nonsystematic PubMed search, selecting the most comprehensive and relevant research articles, clinical trials, translational papers, and review articles on precision oncology and immuno-oncology. Papers were prioritized and selected based on their originality and potential clinical applicability. Two major revolutions have changed cancer treatment paradigms in the past few years: targeting actionable alterations in oncogene-driven cancers and immuno-oncology. Important challenges are still ongoing in both fields of cancer therapy. On the one hand, druggable genomic alterations are diverse and represent only small subsets of patients in certain tumor types, which limits testing their clinical impact in biomarker-driven clinical trials. Next-generation sequencing technologies are increasingly being implemented for molecular prescreening in clinical research, but issues regarding clinical interpretation of large genomic data make their wide clinical use difficult. Further, dealing with tumor heterogeneity and acquired resistance is probably the main limitation for the success of precision oncology. On the other hand, long-term survival benefits with immune checkpoint inhibitors (anti-programmed death cell protein-1/programmed death cell ligand-1[PD-1/L1] and anti-cytotoxic T lymphocyte antigen-4 monoclonal antibodies) are restricted to a minority of patients, and no predictive markers are yet robustly validated that could help us recognize these subsets and optimize treatment delivery and selection. To achieve long-term survival benefits, drug combinations targeting several molecular alterations or cancer hallmarks might be needed. This will probably be one of the most challenging but promising precision cancer treatment strategies in the future. Targeting single molecular

  17. Current status of nuclear physics research

    International Nuclear Information System (INIS)

    Bertulani, Carlos A.; Hussein, Mahir S.

    2015-01-01

    In this review, we discuss the current status of research in nuclear physics which is being carried out in different centers in the world. For this purpose, we supply a short account of the development in the area which evolved over the last nine decades, since the discovery of the neutron. The evolution of the physics of the atomic nucleus went through many stages as more data became available. We briefly discuss models introduced to discern the physics behind the experimental discoveries, such as the shell model, the collective model, the statistical model, the interacting boson model, etc., some of these models may be seemingly in conflict with each other, but this was shown to be only apparent. The richness of the ideas and abundance of theoretical models attests to the important fact that the nucleus is a really singular system in the sense that it evolves from two-body bound states such as the deuteron, to few-body bound states, such as 4 He, 7 Li, 9 Be, etc. and up the ladder to heavier bound nuclei containing up to more than 200 nucleons. Clearly, statistical mechanics, usually employed in systems with very large number of particles, would seemingly not work for such finite systems as the nuclei, neither do other theories which are applicable to condensed matter. The richness of nuclear physics stems from these restrictions. New theories and models are presently being developed. Theories of the structure and reactions of neutron-rich and proton-rich nuclei, called exotic nuclei, halo nuclei, or Borromean nuclei, deal with the wealth of experimental data that became available in the last 35 years. Furthermore, nuclear astrophysics and stellar and Big Bang nucleosynthesis have become a more mature subject. Due to limited space, this review only covers a few selected topics, mainly those with which the authors have worked on. Our aimed potential readers of this review are nuclear physicists and physicists in other areas, as well as graduate students interested

  18. Current status of nuclear physics research

    Energy Technology Data Exchange (ETDEWEB)

    Bertulani, Carlos A. [Department of Physics and Astronomy, Texas A and M University-Commerce (United States); Hussein, Mahir S., E-mail: hussein@if.usp.br [Instituto Tecnologico de Aeronautica (ITA), Sao Jose dos Campos, SP (Brazil). Dept. de Fisica

    2015-12-15

    In this review, we discuss the current status of research in nuclear physics which is being carried out in different centers in the world. For this purpose, we supply a short account of the development in the area which evolved over the last nine decades, since the discovery of the neutron. The evolution of the physics of the atomic nucleus went through many stages as more data became available. We briefly discuss models introduced to discern the physics behind the experimental discoveries, such as the shell model, the collective model, the statistical model, the interacting boson model, etc., some of these models may be seemingly in conflict with each other, but this was shown to be only apparent. The richness of the ideas and abundance of theoretical models attests to the important fact that the nucleus is a really singular system in the sense that it evolves from two-body bound states such as the deuteron, to few-body bound states, such as {sup 4}He, {sup 7}Li, {sup 9}Be, etc. and up the ladder to heavier bound nuclei containing up to more than 200 nucleons. Clearly, statistical mechanics, usually employed in systems with very large number of particles, would seemingly not work for such finite systems as the nuclei, neither do other theories which are applicable to condensed matter. The richness of nuclear physics stems from these restrictions. New theories and models are presently being developed. Theories of the structure and reactions of neutron-rich and proton-rich nuclei, called exotic nuclei, halo nuclei, or Borromean nuclei, deal with the wealth of experimental data that became available in the last 35 years. Furthermore, nuclear astrophysics and stellar and Big Bang nucleosynthesis have become a more mature subject. Due to limited space, this review only covers a few selected topics, mainly those with which the authors have worked on. Our aimed potential readers of this review are nuclear physicists and physicists in other areas, as well as graduate

  19. Current treatment options for meningioma.

    Science.gov (United States)

    Apra, Caroline; Peyre, Matthieu; Kalamarides, Michel

    2018-03-01

    With an annual incidence of 5/100,000, meningioma is the most frequent primary tumor of the central nervous system. Risk factors are radiotherapy and hormone intake. Most meningiomas are grade I benign tumors, but up to 15% are atypical and 2% anaplastic according to the WHO 2016 histological criteria. Areas covered: This review details the current standard therapy based on international guidelines and recent literature, and describes new approaches developed to treat refractory cases. First-line treatments are observation and surgery, but adjuvant radiotherapy/radiosurgery is discussed for atypical and indicated for anaplastic meningiomas. The most problematic cases include skull base meningiomas that enclose vasculo-nervous structures and surgery- and radiation-refractory tumors that present with significant morbidity and mortality. The treatment of recurrent tumors is based on radiotherapy and repeated surgery. Systematic therapies are not effective in general but several clinical trials are ongoing. Expert commentary: Molecular characterization of the tumors, based on genetic mutations such as NF2, SMO, TERT, TRAF7, and on the methylation profile are developing, completing the histological classification and giving new insights into prognosis and treatment options.

  20. Current status of nuclear safety research

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    Efforts at nuclear safety research have expanded year by year in Japan, in term of money and technical achievement. The Atomic Energy Commission set last year the five year nuclear safety research program, a guideline by which various research institutes will be able to develop their own efforts in a concerted manner. From the results of the nuclear safety research which cover very wide areas ranging from reactor engineering safety, safety of nuclear fuel cycle facilities, prevention of radiation hazards to the adequate treatment and disposal of radioactive wastes, AIJ hereafter focuses of LWR engineering safety and prevents two articles, one introducing the current results of the NSSR program developed by JAERI and the other reporting the LWR reliability demonstration testing projects being promoted by MITI. The outline of these demonstration tests was reported in this report. The tests consist of earthquake resistance reliability test of nuclear power plants, steam generator reliability tests, valve integrity tests, fuel assembly reliability tests, reliability tests of heat affected zones and reliability tests of pumps. (Kobatake, H.)

  1. Current status of adrenalectomy for Cushing's disease

    International Nuclear Information System (INIS)

    Brunicardi, F.C.; Rosman, P.M.; Lesser, K.L.; Andersen, D.K.

    1985-01-01

    To evaluate the current use of adrenalectomy in the treatment of Cushing's disease, we reviewed seven consecutive patients who have undergone adrenalectomy for Cushing's disease at this medical center during 1983 to 1984. Seventy-one percent (5/7) had pituitary, or type I, Cushing's disease, while 29% (2/7) had adrenal, or type II, Cushing's disease from either an adenoma or an adrenocortical carcinoma. Presenting signs and symptoms, either initially or at the time of recurrence, were typical of Cushing's syndrome. Four of five patients with type I disease had recurrent disease after transphenoidal hypophysectomy, bilateral adrenalectomy, or unilateral adrenalectomy. In three of five patients, medical therapy of hypercortisolism was abandoned because of adverse side effects. Preoperative evaluation in all patients included cortisol and ACTH levels, dexamethasone suppression tests, and computerized tomography (both abdominal and head). In patients with a prior history of adrenalectomy, radiocholesterol scans were also performed and were useful. Angiographic procedures were not required in these patients. In patients with type I disease, posterior operative approaches were used. In patients with type II disease, an anterolateral approach was used. Posterolateral incisions are preferred over Hugh-Young incisions and provide better exposure with a reduced risk of poor wound healing. Morbidity and mortality included one death and three nonhealing wounds. In the six surviving patients, symptoms resolved with variable frequency. Findings suggestive of Nelson's syndrome (hyperpigmentation) have occurred in two patients; serial computerized tomographic scans fail to reveal evidence of pituitary tumors

  2. Current status of the world's research reactors

    International Nuclear Information System (INIS)

    Dodd, B.

    1999-01-01

    Data from the IAEA's Research Reactor Database (RRDB) provides information with respect to the status of the world's research reactors. Some summary data are given. Recent initiatives by the IAEA regarding communications and information flow with respect to research reactors are discussed. Future plans and perspectives are also introduced. (author)

  3. Current status of the US RERTR Program

    International Nuclear Information System (INIS)

    Travelli, A.

    1982-01-01

    This paper describes the status of the RERTR Program. The main objective is to provide the audience with some orientation and sense of perspective that may assist in viewing the other program presentations as part of an overall effort, rather than as separate and unrelated activities

  4. Current Status of Deep Geological Repository Development

    International Nuclear Information System (INIS)

    Budnitz, R J

    2005-01-01

    This talk provided an overview of the current status of deep-geological-repository development worldwide. Its principal observation is that a broad consensus exists internationally that deep-geological disposal is the only long-term solution for disposition of highly radioactive nuclear waste. Also, it is now clear that the institutional and political aspects are as important as the technical aspects in achieving overall progress. Different nations have taken different approaches to overall management of their highly radioactive wastes. Some have begun active programs to develop a deep repository for permanent disposal: the most active such programs are in the United States, Sweden, and Finland. Other countries (including France and Russia) are still deciding on whether to proceed quickly to develop such a repository, while still others (including the UK, China, Japan) have affirmatively decided to delay repository development for a long time, typically for a generation of two. In recent years, a major conclusion has been reached around the world that there is very high confidence that deep repositories can be built, operated, and closed safely and can meet whatever safety requirements are imposed by the regulatory agencies. This confidence, which has emerged in the last few years, is based on extensive work around the world in understanding how repositories behave, including both the engineering aspects and the natural-setting aspects, and how they interact together. The construction of repositories is now understood to be technically feasible, and no major barriers have been identified that would stand in the way of a successful project. Another major conclusion around the world is that the overall cost of a deep repository is not as high as some had predicted or feared. While the actual cost will not be known in detail until the costs are incurred, the general consensus is that the total life-cycle cost will not exceed a few percent of the value of the

  5. The Current Status of STEM Education Research

    Science.gov (United States)

    Brown, Josh

    2012-01-01

    This paper explores the current Science, Technology, Engineering and Mathematics (STEM) education research base through an analysis of articles from eight journals focused on the STEM disciplines. Analyzed are both practitioner and research publications to determine the current scope of STEM education research, where current STEM education…

  6. Current status and prospects of research reactors

    International Nuclear Information System (INIS)

    Gabaraev, A.B.; Cherepnin, Yu.S.; Tretyakov, I.T.; Khmelshikov, V.V.; Dollezhal, N.A.

    2009-01-01

    Full text: The first nuclear research reactors (RR) appeared in the 1940s. Their initial purpose was to provide knowledge of the main processes associated with neutron-induced nuclear reactions. Later, the rang of problems addressed expanded substantially. Besides fundamental research in the properties of matter, such reactors are successfully used for dealing with problems in the fields of materials science, nuclear engineering, medicine, isotope production, education, etc. Over the whole period of RR fleet growth, more than six hundred nuclear research facilities were built in 70 countries of the world. As of the end of 2008, the number of Russian research reactors in service was about 20% of the globally operating RR fleet. This paper discusses the current status of the world's RR fleet and describes the capabilities of the experimental reactor facilities existing in Russia. In the 21st century, research reactors will remain in demand to solve scientific and technological problems for innovative development of society. The emerging renaissance of nuclear power, the expanding RR uses for production of isotopes and other applications, the increase in the number of countries willing to use nuclear technologies in energy production, industry and science - all contribute to a rebirth of interest in research reactors. One of the ways to improve the experimental capabilities lies in radical upgrading of the reactor facilities with qualitative changes in the main neutronic characteristics of the core. The associated design approaches are illustrated with the example of the IBR-2M reactor at the JNRI in Dubna. The imperative need restricting the spread of nuclear threat leads us to give up using highly enriched uranium in most research reactors. Development of RR fuel with reduced enrichment in uranium has been one of the priority objectives of NIKIET for many years. This paper presents the latest results obtained along these lines, as applied to pool-type research

  7. Current status of neutron scattering in Thailand

    International Nuclear Information System (INIS)

    Ampornrat, Pantip

    1999-01-01

    Thailand's neutron spectrometer has been installed soon after the startup of the reactor. The neutron scattering experiments have been done continuously, although there were some problems involving the neutron intensity and instruments. Development program has been planned for better experimental result. This paper reports the past and present status of neutron scattering equipment and experiments in Thailand. In addition, installation of a HRPD (High Resolution Powder Diffraction) system is included within the scope of the Ongkharak Nuclear Research Center project. (author)

  8. Current status of VHTR development in Japan

    International Nuclear Information System (INIS)

    Aochi, A.; Kondo, T.

    1982-01-01

    The status of the program at the beginning of fiscal 1982 is reviewed. Special emphasis is placed on the altering of the output helium temperature of the experimental VHTR to 950 0 . The modification is aimed at establishing the technical basis for post-experimental VHTR output helium temperature of 1000 0 C. Notes are given on the design of the VHTR as well as various research and development efforts in Japan on multi-purpose nuclear heat applications and HTGR technology

  9. Current status of fast reactor physics

    International Nuclear Information System (INIS)

    Hummel, H.H.

    1979-01-01

    The subject of calculation of reactivity coefficients for fast reactors is developed, starting with a discussion of the status of relevant nuclear data and proceeding to the subjects of group cross section generation and of methods of obtaining reactivity coefficients from group cross sections. Reactivity coefficients measured in critical experiments are compared with calculated values. Dependence of reactivity coefficients on reactor design is discussed. Finally, results of the recent international comparison of calculated reactivity coefficients are presented

  10. Current Status of Peroral Endoscopic Myotomy

    OpenAIRE

    Cho, Young Kwan; Kim, Seong Hwan

    2018-01-01

    Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic ...

  11. [Current status of and prospects for contraception].

    Science.gov (United States)

    Calzolari, E; Parisi, C

    1989-01-01

    It is estimated that at the current rate of growth the world's population will reach 8.5 billion by the year 2025 and 10-11 billion by the end of the 21st century. 90% of this population increase would occur in developing countries, where only 38% of couples used contraceptives during 1980-81 compared to 68% in developed countries. About 300 million couples in the Third World do not use contraceptives, although they do not want more children. Some of these contraceptives include natural steroids, such as progesterone and 17 beta-estradiol that is used for treatment of menopause (1-2 mg daily po). Medroxyprogesterone acetate and norethisterone enanthate depot injections have long-acting properties with low failure rates (3.6% + 0.7 pregnancies/100 women years) if given every 3 months, amenorrhea may occur. RU-486, substance with antiprogesterone activity, inhibits hormonal metabolism during ovulation in a dose of 100 mg/day, just like norgestimate. HRP 102 consists of 50 mg norethisterone enanthate and 5 mg estradiol valerate and cycloprovera contains 25 mg medroxyprogesterone acetate with 5 mg of estradiol cypionate. Both of these agents are effective contraceptives for 2 months. Norplant is implanted subcutaneously in capsule forms. It releases levonorgestrel/LNG for 6-7 years, and in a study of 992 women 2.6 pregnancies occurred for 100 women in the course of 5 years. Vaginal suppositories can release 20 mg/day LNG, or 5-10 mg progesterone/day, and they are considered ideal for nursing mothers. The IUD has been used by 60 million women, however, pelvic inflammatory disease may be associated with its use. Sulprostone and RU-486 (mifepristone) are post ovulatory agents with effectiveness of up to 90 day. Female sterilization has problems of reversibility, male sterilization is less accepted, and other male endocrine approaches producing azoospermia are in the testing phase. The ideal contraceptive with properties of wide acceptability, reversibility, and

  12. Polycystic ovary syndrome: current status and future perspective

    Science.gov (United States)

    Barthelmess, Erin K.; Naz, Rajesh K.

    2015-01-01

    Polycystic ovary syndrome (PCOS) is a widespread reproductive disorder that encompasses many associated health conditions and has an impact on various metabolic processes. PCOS is depicted by hyperandrogenism, polycystic ovaries, and anovulation. It increases the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. The etiology of the disease remains unclear, and the subjective phenotype makes a united diagnosis difficult among physicians. It seems to be a familial genetic syndrome caused by a combination of environmental and genetic factors. It can be linked with metabolic disorders in first-degree family members. PCOS is the cause of up to 30% of infertility in couples seeking treatment. Currently, there is no cure for PCOS. Despite the growing incidence of this syndrome, limited research has been done that encompasses the entirety of PCOS spectrum. In this review, the current status and possible future perspective will be discussed. PMID:24389146

  13. Predictive Toxicology: Current Status and Future Outlook (EBI ...

    Science.gov (United States)

    Slide presentation at the EBI-EMBL Industry Programme Workshop on Predictive Toxicology and the currently status of Computational Toxicology activities at the US EPA. Slide presentation at the EBI-EMBL Industry Programme Workshop on Predictive Toxicology and the currently status of Computational Toxicology activities at the US EPA.

  14. Current status of herbal product: Regulatory overview

    Science.gov (United States)

    Sharma, Sanjay

    2015-01-01

    A review of the regulatory status of herbal drugs/products was done for few countries forming part of Asia, Africa, America, Europe, and Australia, to understand various categories under which the trade of herbal products is permitted and their premarketing requirements. A critical assessment was done, to know the hindrances in the process of harmonization of herbal products. It has been found that there is a lack of harmonization in the regulatory requirements of herbal products internationally, besides the issues of availability of herbs and their conservation. These are hindering the international trade and growth of the herbal products segment. PMID:26681886

  15. Water treatment for fossil fuel power generation - technology status report

    International Nuclear Information System (INIS)

    2006-01-01

    This technology status report focuses on the use of water treatment technology in fossil fuel power plants. The use of polymeric ion exchange resins for deionization of water, the currently preferred use of ion exchange for economically treating water containing low dissolved salts, the use of low pressure high-flux membranes, membrane microfiltration, and reverse osmosis are discussed. Details are given of the benefits of the technologies, water use at power plants, the current status of water treatment technologies, and the potential for future developments, along with power plant market trends and potentials, worldwide developments, and UK capabilities in water treatment plant design and manufacturing

  16. Current status of schistosomiasis in Sokoto, Nigeria

    Directory of Open Access Journals (Sweden)

    Kiran Singh

    2016-09-01

    Full Text Available The study was conducted in poor communities, where most of the population is dependent on river and well for their everyday activities. In this study 5 years–15 years aged children were sampled for schistosomiasis (Urinary and intestinal, using of urine and stool samples. The stool samples were analyzed using kato-katz thick faecal smear technique while the urine samples were analyzed by filtration technique. The overall prevalence of urinary schistosomiasis (Schistosoma haematobium was 60.8% (228 positive cases in 375 samples, and for intestinal schistosomiasis (Schistosoma mansoni was 2.93% (11 positive in 375 samples. The order of infection based on social status (occupation of pupil's parents was farmers > fishermen > traders > civil servents > others. The prevalence of infection based on pupil's water contact activities such as farming associated 84.87% urinary schistosomiasis, followed by swimming (78.21%. Occurrence of urinary schistosomiasis based on source of pupil's drinking water; highest infection was reported among those that drink dam water (75.24% while least infection was occurred whose drinking water was from bore-whole (17.64%. Prevalence of urinary schistosomiasis in the studied area is therefore very high and family status, means of water contact and availability of drinking water dependent. Therefore there is urgent need to adapt preventive measures, provision of safe drinking water as well as control programmes for vector snails, immediately.

  17. Spent fuel management: Current status and prospects

    International Nuclear Information System (INIS)

    1988-12-01

    The main objective of the Advisory Group on Spent Fuel Management is to review the world-wide situation in Spent Fuel Management, to define the most important directions of national efforts and international cooperation in this area, to exchange information on the present status and progress in performing the back-end of Nuclear Fuel Cycle and to elaborate the general recommendations for future Agency programmes in the field of spent fuel management. This report which is a result of the third IAEA Advisory Group Meeting (the first and second were held in 1984 and 1986) is intended to provide the reader with an overview of the status of spent fuel management programmes in a number of leading countries, with a description of the past and present IAEA activities in this field of Nuclear Fuel Cycle and with the Agency's plans for the next years, based on the proposals and recommendations of Member States. A separate abstract was prepared for each of 14 papers presented at the advisory group meeting. Refs, figs and tabs

  18. Radiation Metabolomics: Current Status and Future Directions

    Directory of Open Access Journals (Sweden)

    Smrithi eSugumaran Menon

    2016-02-01

    Full Text Available Human exposure to ionizing radiation disrupts normal metabolic processes in cells and organs by inducing complex biological responses that interfere with gene and protein expression. Conventional dosimetry, monitoring of prodromal symptoms and peripheral lymphocyte counts are of limited value as organ and tissue specific biomarkers for personnel exposed to radiation, particularly, weeks or months after exposure. Analysis of metabolites generated in known stress-responsive pathways by molecular profiling helps to predict the physiological status of an individual in response to environmental or genetic perturbations. Thus, a multi-metabolite profile obtained from a high resolution mass spectrometry-based metabolomics platform offers potential for identification of robust biomarkers to predict radiation toxicity of organs and tissues resulting from exposures to therapeutic or non-therapeutic ionizing radiation. Here, we review the status of radiation metabolomics and explore applications as a standalone technology, as well as its integration in systems biology, to facilitate a better understanding of the molecular basis of radiation response. Finally, we draw attention to the identification of specific pathways that can be targeted for the development of therapeutics to alleviate or mitigate harmful effects of radiation exposure.

  19. Can anesthetic treatment worsen outcome in status epilepticus?

    Science.gov (United States)

    Sutter, Raoul; Kaplan, Peter W

    2015-08-01

    Status epilepticus refractory to first-line and second-line antiepileptic treatments challenges neurologists and intensivists as mortality increases with treatment refractoriness and seizure duration. International guidelines advocate anesthetic drugs, such as continuously administered high-dose midazolam, propofol, and barbiturates, for the induction of therapeutic coma in patients with treatment-refractory status epilepticus. The seizure-suppressing effect of anesthetic drugs is believed to be so strong that some experts recommend using them after benzodiazepines have failed. Although the rationale for the use of anesthetic drugs in patients with treatment-refractory status epilepticus seems clear, the recommendation of their use in treating status epilepticus is based on expert opinions rather than on strong evidence. Randomized trials in this context are lacking, and recent studies provide disturbing results, as the administration of anesthetics was associated with poor outcome independent of possible confounders. This calls for caution in the straightforward use of anesthetics in treating status epilepticus. However, there are still more questions than answers, and current evidence for the adverse effects of anesthetic drugs in patients with status epilepticus remains too limited to advocate a change of treatment algorithms. In this overview, the rationale and the conflicting clinical implications of anesthetic drugs in patients with treatment-refractory status epilepticus are discussed, and remaining questions are elaborated. This article is part of a Special Issue entitled "Status Epilepticus". Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Current Status of Peroral Endoscopic Myotomy.

    Science.gov (United States)

    Cho, Young Kwan; Kim, Seong Hwan

    2018-01-01

    Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus. Contraindications include prior radiation therapy to the esophagus and prior extensive esophageal mucosal resection/ablation involving the POEM field. Most of the complications are minor and self-limited and can be managed conservatively. As POEM emerged as the main treatment for achalasia, various adaptations to tunnel endoscopic surgery have been attempted. Tunnel endoscopic surgery includes POEM, peroral endoscopic tumor resection, gastric peroral endoscopic pyloromyotomy. POEM has been widely accepted as a treatment for all types of achalasia, even for specific cases such as achalasia with failed prior treatments, and hypertensive motor disorders.

  1. Current Status of Peroral Endoscopic Myotomy

    Science.gov (United States)

    Cho, Young Kwan; Kim, Seong Hwan

    2018-01-01

    Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus. Contraindications include prior radiation therapy to the esophagus and prior extensive esophageal mucosal resection/ablation involving the POEM field. Most of the complications are minor and self-limited and can be managed conservatively. As POEM emerged as the main treatment for achalasia, various adaptations to tunnel endoscopic surgery have been attempted. Tunnel endoscopic surgery includes POEM, peroral endoscopic tumor resection, gastric peroral endoscopic pyloromyotomy. POEM has been widely accepted as a treatment for all types of achalasia, even for specific cases such as achalasia with failed prior treatments, and hypertensive motor disorders. PMID:29397656

  2. Current Status of Peroral Endoscopic Myotomy

    Directory of Open Access Journals (Sweden)

    Young Kwan Cho

    2018-01-01

    Full Text Available Peroral endoscopic myotomy (POEM has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus. Contraindications include prior radiation therapy to the esophagus and prior extensive esophageal mucosal resection/ablation involving the POEM field. Most of the complications are minor and self-limited and can be managed conservatively. As POEM emerged as the main treatment for achalasia, various adaptations to tunnel endoscopic surgery have been attempted. Tunnel endoscopic surgery includes POEM, peroral endoscopic tumor resection, gastric peroral endoscopic pyloromyotomy. POEM has been widely accepted as a treatment for all types of achalasia, even for specific cases such as achalasia with failed prior treatments, and hypertensive motor disorders.

  3. Current Status of Fractional Laser Resurfacing.

    Science.gov (United States)

    Carniol, Paul J; Hamilton, Mark M; Carniol, Eric T

    2015-01-01

    Fractional lasers were first developed based on observations of lasers designed for hair transplantation. In 2007, ablative fractional laser resurfacing was introduced. The fractionation allowed deeper tissue penetration, leading to greater tissue contraction, collagen production and tissue remodeling. Since then, fractional erbium:YAG resurfacing lasers have also been introduced. These lasers have yielded excellent results in treating photoaging, acne scarring, and dyschromia. With the adjustment of microspot density, pulse duration, number of passes, and fluence, the surgeon can adjust the treatment effects. These lasers have allowed surgeons to treat patients with higher Fitzpatrick skin types (types IV to VI) and greater individualize treatments to various facial subunits. Immunohistochemical analysis has demonstrated remodeling effects of the tissues for several months, producing longer lasting results. Adjuvant treatments are also under investigation, including concomitant face-lift, product deposition, and platelet-rich plasma. Finally, there is a short recovery time from treatment with these lasers, allowing patients to resume regular activities more quickly. Although there is a relatively high safety profile for ablative fractionated lasers, surgeons should be aware of the limitations of specific treatments and the associated risks and complications.

  4. Current status of water chemistry in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Ishigure, K. [Saitama Inst. of Tech. (Japan)

    2002-07-01

    At present 28 BWRs including 2 ABWRs and 23 PWRs are in operation in Japan and generated 36.8{open_square} of total electric power in 1998. Totally 4 BWRs, of which two are ABWRs, are now under construction, and one BWR together with one ABWR is in the stage of planning. One gas-cooled reactor (Tokai-1) was shut down permanently in 1998 and last year entered into decommissioning stage. According to the Japanese 2001 plan of electric power supply, 13 nuclear power plants newly constructed are to start operation in the next 10 years. In this paper the recent status of water chemistry technology in Japanese nuclear power plants is briefly summarized together with a touch upon the activities in the fundamental research. (author)

  5. Current status of water chemistry in Japan

    International Nuclear Information System (INIS)

    Ishigure, K.

    2002-01-01

    At present 28 BWRs including 2 ABWRs and 23 PWRs are in operation in Japan and generated 36.8□ of total electric power in 1998. Totally 4 BWRs, of which two are ABWRs, are now under construction, and one BWR together with one ABWR is in the stage of planning. One gas-cooled reactor (Tokai-1) was shut down permanently in 1998 and last year entered into decommissioning stage. According to the Japanese 2001 plan of electric power supply, 13 nuclear power plants newly constructed are to start operation in the next 10 years. In this paper the recent status of water chemistry technology in Japanese nuclear power plants is briefly summarized together with a touch upon the activities in the fundamental research. (author)

  6. Current nutritional treatments of obesity.

    Science.gov (United States)

    Greenwald, Ashli

    2006-01-01

    Obesity in our country is a growing concern. There are several different options for weight loss; however, individuals must be self-motivated and amendable to change in order to achieve success with their weight loss goals. Several strategies used by professionals in the US today to treat overweight and obesity, include diet therapy, exercise, behavior modification, pharmacotherapy, and surgery. The focus of the American Dietetic Association (ADA) Weight Management Position Statement is no longer just on weight loss but now on weight management. Reaching one's ideal body weight is recommended but not often realistic. Frequently, the goal of treatment shifts to maintenance of ones current weight or attempts at moderate weight loss. Lifestyle modification or behavioral modification interventions rely on analyzing behavior to identify events that are associated with appropriate vs. inappropriate eating, exercise, or thinking habits. Certain primary strategies that have been found to be useful for helping people change their behaviors so that they can lose weight and maintain their weight loss, include self-monitoring, stimulus control, cognitive restructuring, stress management, social support, physical activity, and relapse prevention. Weight loss programs should strive to combine a nutritionally balanced dietary regimen with exercise and lifestyle modifications at the lowest possible cost. There are several different methods used for dietary modifications; low calorie diets, very low calorie diets, fasting, formula diets and meal replacement programs, and popular diets. Bariatric surgery is gaining popularity as it has been an effective way to treat obesity. Following gastric bypass surgery, the patients must be prepared to modify their eating behaviors and dietary selections to assist with weight loss and prevent potential complications. Patients should be educated on the dietary guidelines extensively prior to surgery and again post-operatively.

  7. Current status of neutron scattering in Thailand

    International Nuclear Information System (INIS)

    Kornduangkaeo, Areeratt; Pongkasem, Somchai; Putchar, Suriya; Ampornrat, Pantip; Kajornrith, Varavuth; Sangariyavanich, Archara

    2003-01-01

    The current neutron powder diffractometer at the Thai Research Reactor-1/M1 (TRR-1/M1) has been modified from the obsolete neutron diffractometer which had been used during 1968-1975. The upgraded diffractometer has medium resolution and is appropriate for studying samples with small unit cell dimensions and training university students in the field of neutron scattering. This paper describes the current activities of neutron scattering research in Thailand as well as a new research reactor for enlarging the perspectives of its utilization in the future. (author)

  8. Current Status of Astrophysics of Cosmic Rays

    Science.gov (United States)

    Moskalenko, Igor

    2016-03-01

    I will review the current instrumentation and recent results. I will discuss which measurements have to be done in the near future to significantly advance our knowledge about the phenomenon of cosmic rays, their sources, and their interactions with the interstellar medium. A support from NASA APRA Grant No. NNX13AC47G is greatly acknowledged.

  9. Metformin Pharmacogenomics: Current Status and Future Directions

    Science.gov (United States)

    Pawlyk, Aaron C.; Giacomini, Kathleen M.; McKeon, Catherine; Shuldiner, Alan R.

    2014-01-01

    The incidence of type 2 diabetes (T2D) and its costs to the health care system continue to rise. Despite the availability of at least 10 drug classes for the treatment of T2D, metformin remains the most widely used first-line pharmacotherapy for its treatment; however, marked interindividual variability in response and few clinical or biomarker predictors of response reduce its optimal use. As clinical care moves toward precision medicine, a variety of broad discovery-based “omics” approaches will be required. Technical innovation, decreasing sequencing cost, and routine sample storage and processing has made pharmacogenomics the most widely applied discovery-based approach to date. This opens up the opportunity to understand the genetics underlying the interindividual variation in metformin responses in order for clinicians to prescribe specific treatments to given individuals for better efficacy and safety: metformin for those predicted to respond and alternative therapies for those predicted to be nonresponders or who are at increased risk for adverse side effects. Furthermore, understanding of the genetic determinants of metformin response may lead to the identification of novel targets and development of more effective agents for diabetes treatment. The goals of this workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases were to review the state of research on metformin pharmacogenomics, discuss the scientific and clinical hurdles to furthering our knowledge of the variability in patient responses to metformin, and consider how to effectively use this increased understanding to improve patient outcomes. PMID:25060887

  10. Current status of Paragonimus and paragonimiasis in Ecuador

    Directory of Open Access Journals (Sweden)

    Manuel Calvopiña

    2014-11-01

    Full Text Available A review of national and international publications on paragonimiasis in Ecuador, epidemiological records from the Ministry of Public Health and unpublished research data was conducted to summarise the current status of the parasite/disease. The purpose of the review is to educate physicians, policy-makers and health providers on the status of the disease and to stimulate scientific investigators to conduct further research. Paragonimiasis was first diagnosed in Ecuador 94 years ago and it is endemic to both tropical and subtropical regions in 19 of 24 provinces in the Pacific Coast and Amazon regions. Paragonimus mexicanus is the only known species in the country, with the mollusc Aroapyrgus colombiensis and the crabs Moreirocarcinus emarginatus, Hypolobocera chilensis and Hypolobocera aequatorialis being the primary and secondary intermediate hosts, respectively. Recent studies found P. mexicanus metacercariae in Trichodactylus faxoni crabs of the northern Amazon. Chronic pulmonary paragonimiasis is commonly misdiagnosed and treated as tuberculosis and although studies have demonstrated the efficacy of praziquantel and triclabendazole for the treatment of human infections, neither drug is available in Ecuador. Official data recorded from 1978-2007 indicate an annual incidence of 85.5 cases throughout the 19 provinces, with an estimated 17.2% of the population at risk of infection. There are no current data on the incidence/prevalence of infection, nor is there a national control programme.

  11. Drugs in development for toxoplasmosis: advances, challenges, and current status.

    Science.gov (United States)

    Alday, P Holland; Doggett, Joseph Stone

    2017-01-01

    Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are currently used to treat toxoplasmosis commonly have toxic side effects and require prolonged courses that range from weeks to more than a year. The need for long treatment durations and the risk of relapsing disease are in part due to the lack of efficacy against T. gondii tissue cysts. The challenges for developing a more effective treatment for toxoplasmosis include decreasing toxicity, achieving therapeutic concentrations in the brain and eye, shortening duration, eliminating tissue cysts from the host, safety in pregnancy, and creating a formulation that is inexpensive and practical for use in resource-poor areas of the world. Over the last decade, significant progress has been made in identifying and developing new compounds for the treatment of toxoplasmosis. Unlike clinically used medicines that were repurposed for toxoplasmosis, these compounds have been optimized for efficacy against toxoplasmosis during preclinical development. Medicines with enhanced efficacy as well as features that address the unique aspects of toxoplasmosis have the potential to greatly improve toxoplasmosis therapy. This review discusses the facets of toxoplasmosis that are pertinent to drug design and the advances, challenges, and current status of preclinical drug research for toxoplasmosis.

  12. Energy sector in Ecuador: Current status

    International Nuclear Information System (INIS)

    Pelaez-Samaniego, M.R.; Garcia-Perez, M.; Cortez, L.A.B.; Oscullo, J.; Olmedo, G.

    2007-01-01

    This paper describes the current energy sector in Ecuador, its present structure, the oil industry, subsidies, and renewable energy, focusing on the evolution and reform of the electricity sector. Currently, 86% of the primary energy originates from nonrenewable sources. In 2005, the gross electricity generation was 15 127 GWh (45.5% hydropower, 43.11% thermal, and 11.39% imported). Ecuador is the fifth largest oil producer in South America but lacks sufficient oil refining capacity. Reserves of natural gas (NG) are small, and most of NG is produced from oil fields without energy recovery. Several projects are underway to increase the utilization of NG and renewable energies to meet Ecuador commitments to the Kyoto Protocol

  13. Supersymmetry: Current status and future prospects

    International Nuclear Information System (INIS)

    Baer, H.; Barnett, R.M.; Bhattacharya, G.

    1990-11-01

    We review the most recent data from e + e - and p bar p colliders and discuss the resulting constraints on the parameters of the Minimal Supersymmetric Standard Model, and their implications for future supersymmetry searches. We review the patterns of cascade decays of squarks and gluinos and discuss the present status of supersymmetry event generators for hadron colliders. We present the results of detailed simulations of E T and same sign dilepton events from supersymmetry at the Tevatron. Although the E T signal continues to be viable, it is concluded that the same sign dilepton signal may be too small unless squarks and gluinos are approximately degenerate. The E T and the same-sign dilepton signals from supersymmetry and the Standard Model backgrounds at the SSC are also discussed in detail. We also discuss other promising ways of searching for supersymmetry at the SSC including events containing Z degree bosons, and events containing n isolated leptons (n ≥ 3). Finally, we discuss how supersymmetry searches might be modified if the Higgs sectors is more complicated or if R-parity is not conserved due to baryon number violating interactions. 49 refs., 12 figs

  14. Cacao biotechnology: current status and future prospects.

    Science.gov (United States)

    Wickramasuriya, Anushka M; Dunwell, Jim M

    2018-01-01

    Theobroma cacao-The Food of the Gods, provides the raw material for the multibillion dollar chocolate industry and is also the main source of income for about 6 million smallholders around the world. Additionally, cocoa beans have a number of other nonfood uses in the pharmaceutical and cosmetic industries. Specifically, the potential health benefits of cocoa have received increasing attention as it is rich in polyphenols, particularly flavonoids. At present, the demand for cocoa and cocoa-based products in Asia is growing particularly rapidly and chocolate manufacturers are increasing investment in this region. However, in many Asian countries, cocoa production is hampered due to many reasons including technological, political and socio-economic issues. This review provides an overview of the present status of global cocoa production and recent advances in biotechnological applications for cacao improvement, with special emphasis on genetics/genomics, in vitro embryogenesis and genetic transformation. In addition, in order to obtain an insight into the latest innovations in the commercial sector, a survey was conducted on granted patents relating to T. cacao biotechnology. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  15. Current Status of Pyroprocessing Development at KAERI

    Directory of Open Access Journals (Sweden)

    Hansoo Lee

    2013-01-01

    Full Text Available Pyroprocessing technology has been actively developed at Korea Atomic Energy Research Institute (KAERI to meet the necessity of addressing spent fuel management issue. This technology has advantages over aqueous process such as less proliferation risk, treatment of spent fuel with relatively high heat and radioactivity, and compact equipments. This paper describes the pyroprocessing technology development at KAERI from head-end process to waste treatment. The unit process with various scales has been tested to produce the design data associated with scale-up. Pyroprocess integrated inactive demonstration facility (PRIDE was constructed at KAERI and it began test operation in 2012. The purpose of PRIDE is to test the process regarding unit process performance, remote operation of equipments, integration of unit processes, scale-up of process, process monitoring, argon environment system operation, and safeguards-related activities. The test of PRIDE will be promising for further pyroprocessing technology development.

  16. The current status of grazing incidence optics

    International Nuclear Information System (INIS)

    Aschenbach, B.

    1983-01-01

    The developments in the area of grazing incidence optics with emphasis on telescopes for use in X-ray astronomy are reviewed. The performance of existing high-resolution telescopes is outlined and compared with those expected from future missions like ROSAT and AXAF. Starting from the basic principles of X-ray reflection and scattering, an attempt is made to highlight the current understanding of X-ray mirror physics using new theoretical ideas as well as experimental laboratory results. (author)

  17. State Emergency Department Opioid Guidelines: Current Status.

    Science.gov (United States)

    Broida, Robert I; Gronowski, Tanner; Kalnow, Andrew F; Little, Andrew G; Lloyd, Christopher M

    2017-04-01

    The purpose of this study was to evaluate and categorize current state-sponsored opioid guidelines for the practice of emergency medicine (EM). We conducted a comprehensive search of EM-specific opioid prescribing guidelines and/or policies in each state to determine current state involvement in EM opioid prescribing, as well as to evaluate some of the specifics of each guideline or policy. The search was conducted using an online query and a follow-up email request to each state chapter of ACEP. We found that 17 states had emergency department-specific guidelines. We further organized the guidelines into four categories: limiting prescriptions for opioids with 67 total recommendations; preventing/diverting abuse with 56 total recommendations; addiction-related guidelines with 29 total recommendations; and a community resources section with 24 total recommendations. Our results showed that current state guidelines focus on providers limiting opioid pain prescriptions and vetting patients for possible abuse/diversion. This study highlights the 17 states that have addressed opioid prescribing guidelines and categorizes their efforts to date. It is hoped that this study will provide the basis for similar efforts in other states.

  18. Current treatment of Graves' disease

    International Nuclear Information System (INIS)

    Harada, T.; Shimaoka, K.; Mimura, T.; Ito, K.

    1987-01-01

    In this review we have described the rationale for the appropriate treatment of patients with Graves' disease. Because the etiology of this disorder remains obscure, its management remains controversial. Since antithyroid drugs and radioiodine became readily available in the early 1950s, they have been widely used for the treatment of thyrotoxicosis, and the number of cases treated surgically has markedly decreased. However, almost four decades of experience have disclosed an unexpectedly high incidence of delayed hypothyroidism after radioiodine treatment and a low remission rate after antithyroid therapy. As a result, surgery is again being advocated as the treatment of choice. The three modalities of treatment have different advantages and disadvantages, and selection of treatment is of importance. In principle, we believe that for most patients a subtotal thyroidectomy should be performed after the patient has been rendered euthyroid by antithyroid drugs. We attempt to leave a thyroid remnant of 6 to 8 gm.36 references

  19. Current status of SFR development in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Ieda, Yoshiaki; Chikazawa, Yoshitaka [Japan Atomic Energy Agency, Tokyo (Japan). Project Promotion Office; Kotake, Shoji [Japan Atomic Power Company, Tokyo (Japan)

    2012-03-15

    Fast Reactor development experiences and status in Japan are summarized. Even though international SFR circumstances were against in 1980s and 1990s, e.g. CRBRP, SNR-300 and Superphenix terminations, we kept on with our R and D activities steadily aiming at positive development targets in Japan. As results of our efforts, it has shown that our commercialized SFR concept, Japan Sodium-cooled Fast Reactor (JSFR) could meet the targets in the Feasibility Study on Commercialized Fast Reactor Cycle Systems (FS) and the Fast Reactor Cycle Technology Development (FaCT) project. Further, Monju has finally achieved restart in May 2010 after having been shut for almost 15 years. A future plan of Monju is to be determined based on a direction of the national nuclear and energy policies that will be established in 2012. The undergoing FaCT project is pursuing commercialization of fast reactor cycle system around 2050 under cooperation of MEXT (Ministry of Education, Culture, Sports, Science and Technology), METI (Ministry of Economy, Trade and Industry), utilities, venders and JAEA (Japan Atomic Energy Agency). As results of the FaCT Phase I, feasibility of the key technologies for JSFR has been evaluated and the project is waiting for launching the phase II due to the Tohoku large earthquake. It is considered that the nuclear development policy might be affected by the Tohoku large Earthquake/Tsunami in Japan. Nevertheless the significance of nuclear energy will not be changed and thus we will focus on the issues learnt from Fukushima accidents and reflect into the improvement of the safety of Monju and the safety design criteria for the next generation Fast Reactor systems. (orig.)

  20. Current status of SFR development in Japan

    International Nuclear Information System (INIS)

    Ieda, Yoshiaki; Chikazawa, Yoshitaka

    2012-01-01

    Fast Reactor development experiences and status in Japan are summarized. Even though international SFR circumstances were against in 1980s and 1990s, e.g. CRBRP, SNR-300 and Superphenix terminations, we kept on with our R and D activities steadily aiming at positive development targets in Japan. As results of our efforts, it has shown that our commercialized SFR concept, Japan Sodium-cooled Fast Reactor (JSFR) could meet the targets in the Feasibility Study on Commercialized Fast Reactor Cycle Systems (FS) and the Fast Reactor Cycle Technology Development (FaCT) project. Further, Monju has finally achieved restart in May 2010 after having been shut for almost 15 years. A future plan of Monju is to be determined based on a direction of the national nuclear and energy policies that will be established in 2012. The undergoing FaCT project is pursuing commercialization of fast reactor cycle system around 2050 under cooperation of MEXT (Ministry of Education, Culture, Sports, Science and Technology), METI (Ministry of Economy, Trade and Industry), utilities, venders and JAEA (Japan Atomic Energy Agency). As results of the FaCT Phase I, feasibility of the key technologies for JSFR has been evaluated and the project is waiting for launching the phase II due to the Tohoku large earthquake. It is considered that the nuclear development policy might be affected by the Tohoku large Earthquake/Tsunami in Japan. Nevertheless the significance of nuclear energy will not be changed and thus we will focus on the issues learnt from Fukushima accidents and reflect into the improvement of the safety of Monju and the safety design criteria for the next generation Fast Reactor systems. (orig.)

  1. Current status of family health in Mexico

    Directory of Open Access Journals (Sweden)

    Apolinar Membrillo Luna

    2013-01-01

    Full Text Available Family Health (FH has three main elements: individual health, life material conditions and family functioning. Its main actors are the individual, the family and society. A common framework is the basis of FH, as each one of these elements is extremely important. Currently, in Mexico two aspects are considered: epidemiological studies and those inherent to the family medicine specialty. That latter has a residency and an integrated specialty curriculum, as well as certification from the corresponding board. All of this allows us to apply the HF approach to each and every family and individual that is cared for.

  2. Lactate biosensors: current status and outlook.

    Science.gov (United States)

    Rassaei, Liza; Olthuis, Wouter; Tsujimura, Seiya; Sudhölter, Ernst J R; van den Berg, Albert

    2014-01-01

    Many research efforts over the last few decades have been devoted to sensing lactate as an important analytical target in clinical care, sport medicine, and food processing. Therefore, research in designing lactate sensors is no longer in its infancy and now is more directed toward viable sensors for direct applications. In this review, we provide an overview of the most immediate and relevant developments toward this end, and we discuss and assess common transduction approaches. Further, we critically describe the pros and cons of current commercial lactate sensors and envision how future sensing design may benefit from emerging new technologies.

  3. Sensing technology current status and future trends

    CERN Document Server

    Mukhopadhyay, Subhas; Jayasundera, Krishanthi; Bhattacharyya, Nabarun

    2014-01-01

    This book is written for academic and industry professionals working in the field of sensing, instrumentation and related fields, and is positioned to give a snapshot of the current state of the art in sensing technology, particularly from the applied perspective.  The book is intended to give a broad overview of the latest developments, in addition to discussing the process through which researchers go through in order to develop sensors, or related systems, which will become more widespread in the future.  

  4. CURRENT PRINCIPLES FOR CRANIOPHARYNGIOMA TREATMENT

    Directory of Open Access Journals (Sweden)

    A. N. Konovalov

    2012-01-01

    Full Text Available The paper describes the classification and treatment options of craniopharyngiomas, benign epithelial tumors arising from the cell remains of the Rathke’s pouch. It presents a few types of surgical accesses during surgical treatment for this disease and gives examples of how to place an Ommaya reservoir. 

  5. Current status of hybrid coronary revascularization.

    Science.gov (United States)

    Jaik, Nikhil P; Umakanthan, Ramanan; Leacche, Marzia; Solenkova, Natalia; Balaguer, Jorge M; Hoff, Steven J; Ball, Stephen K; Zhao, David X; Byrne, John G

    2011-10-01

    Hybrid coronary revascularization combines coronary artery bypass surgery with percutaneous coronary intervention techniques to treat coronary artery disease. The potential benefits of such a technique are to offer the patients the best available treatments for coronary artery disease while minimizing the risks of the surgery. Hybrid coronary revascularization has resulted in the establishment of new 'hybrid operating suites', which incorporate and integrate the capabilities of a cardiac surgery operating room with that of an interventional cardiology laboratory. Hybrid coronary revascularization has greatly augmented teamwork and cooperation between both fields and has demonstrated encouraging as well as good initial outcomes.

  6. Current status of bicarbonate in CKD.

    Science.gov (United States)

    Dobre, Mirela; Rahman, Mahboob; Hostetter, Thomas H

    2015-03-01

    Metabolic acidosis was one of the earliest complications to be recognized and explained pathologically in patients with CKD. Despite the accumulated evidence of deleterious effects of acidosis, treatment of acidosis has been tested very little, especially with respect to standard clinical outcomes. On the basis of fundamental research and small alkali supplementation trials, correcting metabolic acidosis has a strikingly broad array of potential benefits. This review summarizes the published evidence on the association between serum bicarbonate and clinical outcomes. We discuss the role of alkali supplementation in CKD as it relates to retarding kidney disease progression, improving metabolic and musculoskeletal complications. Copyright © 2015 by the American Society of Nephrology.

  7. [Current status of dermatomicrobiology. An overview].

    Science.gov (United States)

    Sonntag, A K; Schwanitz, H J

    2002-04-01

    The new German laws dealing with protection against infectious diseases (Infektionsschutzgesetz of 1.1.2001) have reconfirmed the importance of microbiology as a basic science and infectiology as a multi-disciplinary clinical discipline. Concerning dermatological diagnosis and therapy, the implementation of molecular biological techniques has a decisive influence. The discovery of new (e.g. Helicobacter pylori) and the better detection of known organisms (e.g. Chlamydia, Borrelia) suggested findings in questions of causality and therapeutic developments. Concerning the infections of the skin this synopsis provides the state of the art of diagnostic process and treatment in mycology, bacteriology and virology.

  8. Current status of nuclear engineering education

    International Nuclear Information System (INIS)

    Palladino, N.J.

    1975-01-01

    The 65 colleges and universities offering undergraduate degrees in nuclear engineering and the 15 schools offering strong nuclear engineering options are, in general, doing a good job to meet the current spectrum of job opportunities. But, nuclear engineering programs are not producing enough graduates to meet growing demands. They currently receive little aid and support from their customers --industry and government--in the form of scholarships, grants, faculty research support, student thesis and project support, or student summer jobs. There is not enough interaction between industry and universities. Most nuclear engineering programs are geared too closely to the technology of the present family of reactors and too little to the future breeder reactors and controlled thermonuclear reactors. In addition, nuclear engineering programs attract too few women and members of minority ethnic groups. Further study of the reasons for this fact is needed so that effective corrective action can be taken. Faculty in nuclear engineering programs should assume greater initiative to provide attractive and objective nuclear energy electives for technical and nontechnical students in other disciplines to improve their technical understanding of the safety and environmental issues involved. More aggressive and persistent efforts must be made by nuclear engineering schools to obtain industry support and involvement in their programs

  9. Esophageal tissue engineering: Current status and perspectives.

    Science.gov (United States)

    Poghosyan, T; Catry, J; Luong-Nguyen, M; Bruneval, P; Domet, T; Arakelian, L; Sfeir, R; Michaud, L; Vanneaux, V; Gottrand, F; Larghero, J; Cattan, P

    2016-02-01

    Tissue engineering, which consists of the combination and in vivo implantation of elements required for tissue remodeling toward a specific organ phenotype, could be an alternative for classical techniques of esophageal replacement. The current hybrid approach entails creation of an esophageal substitute composed of an acellular matrix and autologous epithelial and muscle cells provides the most successful results. Current research is based on the use of mesenchymal stem cells, whose potential for differentiation and proangioogenic, immune-modulator and anti-inflammatory properties are important assets. In the near future, esophageal substitutes could be constructed from acellular "intelligent matrices" that contain the molecules necessary for tissue regeneration; this should allow circumvention of the implantation step and still obtain standardized in vivo biological responses. At present, tissue engineering applications to esophageal replacement are limited to enlargement plasties with absorbable, non-cellular matrices. Nevertheless, the application of existing clinical techniques for replacement of other organs by tissue engineering in combination with a multiplication of translational research protocols for esophageal replacement in large animals should soon pave the way for health agencies to authorize clinical trials. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  10. PREHYPERTENSION: WHAT IS THE CURRENT STATUS?

    Directory of Open Access Journals (Sweden)

    CHIA YC

    2008-01-01

    Full Text Available Cardiovascular disease (CVD risk is a continuum across blood pressure. The term prehypertension was introduced because it is now recognized that blood pressure readings between what is deemed optimal and hypertension is associated with increased CVD risk. The prevalence of prehypertension is high and the progression to hypertension is also high. Prehypertension is also commonly associated with other CVD risk factors namely dyslipidaemia, dysgylcaemia and overweight/obesity. Eighty-five percent of prehypertensives have one other or more CVD risk factor compared to normotensives. A recent study has shown a reduction in the development of hypertension from prehypertension with the use of an angiotensin receptor blocker. Unfortunately to date, the impact of treatment of prehypertension on CVD outcome is still unknown except in those with high CVD risk like diabetes or established CVD. However this does not mean nothing can be done for those with prehypertension. The aim of managing prehypertension is to lower the BP, prevent progression to hypertension and to prevent BP related CVD deaths. Lifestyle changes can reduce BP and this by itself can lower CVD risk. Until more evidence about other modalities of treatment become available this is a sensible and cost-effective way to manage prehypertension.

  11. Current status of the RERTR program

    International Nuclear Information System (INIS)

    Travelli, Armando

    1983-01-01

    The main purpose of this paper is to review the progress which has been accomplished by the RERTR Program during the past year, the present status of the program, the activities which are now in progress, and the program plans for the coming years. The main program objectives have not changed during the past year. The primary goal of the RERTR Program is still to reduce the amount of HEU which is shipped and used around the world in research reactors and, with it, the nuclear proliferation potential which it creates. Also unchanged is the program objective to reduce HEU use without significant penalty to the reactors involved. This means that for every possible conversion, our technical goal is to achieve good experiment capabilities and the economic advantages that come from a long core lifetime and from relatively economical fuels. We also intend to limit as much as possible the modifications which may have to be made to the reactor in order to achieve conversion and, last but not least, we intend to avoid any significant problems that might appear in the safety and licensing areas. Other important goals are the sharing of information about reduced-enrichment technology and providing technical assistance to the U.S. Government on special problems that may affect implementation of its policies. The timetable of the RERTR Program has stretched slightly. At the time of the previous ANL Conference, a long range goal was set which was anticipated to require about five or six years. This happened in 1978 and, therefore, the long range goal was considered to be achievable by 1984. This final deadline, the time when the long term goal of technical convertibility of all research reactors can be achieved, has now been moved to 1986. In the meantime, good progress has been made towards the near-term goals. Much more detailed knowledge is available about what lies ahead from a technical point of view. In addition, the general level of confidence in the achievability of the

  12. Current status of automated breast ultrasonography

    Directory of Open Access Journals (Sweden)

    Hee Jung Shin

    2015-07-01

    Full Text Available Breast ultrasonography (US is currently considered the first-line examination in the detection Epub ahead of print and characterization of breast lesions. However, conventional handheld US (HHUS has several limitations such as operator dependence and the requirement of a considerable amount of radiologist time for whole-breast US. Automated breast US (ABUS, recently approved by the United States Food and Drug Administration for screening purposes, has several advantages over HHUS, such as higher reproducibility, less operator dependence, and less required physician time for image acquisition. In addition, ABUS provides both a coronal view and a relatively large field of view. Recent studies have reported that ABUS is promising in US screening for women with dense breasts and can potentially replace handheld second-look US in a preoperative setting.

  13. Chikungunya fever: current status in Mexico.

    Science.gov (United States)

    Nava-Frías, Margarita; Searcy-Pavía, Ricardo Efrén; Juárez-Contreras, Carina Aurora; Valencia-Bautista, Anayeli

    Chikungunya fever is a tropical vector-borne disease that has been spreading rapidly around the world during the last 10 years, and which has been usually misdiagnosed as dengue. Nowadays, this disease is increasing in Mexico, mainly in the southern and central zones of the country, being significantly more common in women, children and young adults (28% in<20 years of age). The classical presentation includes fever, arthralgia, polyarthritis, back-pain, and skin rashes. Although symptoms and treatment are similar to those for dengue, there are key clinical features to differentiate these two diseases. Copyright © 2016 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  14. Current status of nephrogenic systemic fibrosis

    International Nuclear Information System (INIS)

    Daftari Besheli, L.; Aran, S.; Shaqdan, K.; Kay, J.; Abujudeh, H.

    2014-01-01

    Nephrogenic systemic fibrosis (NSF) occurs in patients with advanced chronic kidney disease (CKD) or acute renal failure, most commonly following exposure to gadolinium-based contrast agents (GBCAs). NSF can be debilitating and associated with increased mortality. The putative association of NSF with GBCAs prompted the development of guidelines to limit the use of these contrast agents in at-risk patients. Indeed, the incidence of NSF has decreased dramatically following application of these guidelines, which appears to be the only effective means of decreasing NSF incidence. Thus, increasing clinician awareness of these updated guidelines is important. The present review introduces and compares updated guidelines for GBCA use and discusses the latest advances in the understanding of the pathogenic mechanisms and treatment of NSF

  15. ILRS: Current Status and Future Challenges

    Science.gov (United States)

    Pearlman, M. R.; Bianco, G.; Merkowitz, S.; Noll, C. E.; Pavlis, E. C.; Shargorodsky, V.; Zhongping, Z.

    2016-12-01

    The International Laser Ranging Service (ILRS) is expanding its ground tracking capability with new stations and upgrades to current stations. Our Russian colleagues have installed new stations in Brasilia and South Africa, and have several other sites in process or in planning. The NASA Space Geodesy Program is preparing equipment for U.S. sites (McDonald and Haleakala) and with the Norwegian National Mapping Agency in Ny Ålesund; further deployments are planned. Upgrades continue at sites in China, and new sites are underway or planned in Europe and India. Stations are moving to higher repetition rates and more efficient detection to enhance satellite interleaving capability; some stations have already implemented automated processes that could lead to around-the-clock operation to increase temporal coverage and to make more efficient use of personnel. The ILRS roster of supported satellites continues to grow with the addition of the LARES satellite to augment tracking for the improvement of the ITRF. New GNSS constellations and geosynchronous satellites now bring the total roster to over 80 satellites - so much so, that new tracking strategies and time and location multiplexing are under consideration. There continues to be strong interest in Lunar Ranging. New applications of one-way and two-way laser ranging include ps-accurate time transfer, laser transponders for interplanetary ranging, and tracking of space debris. New laser ranging data products are being developed, including satellite orbit products, satellite orientation, gravity field products, and products to characterize the quality of data and station performance. This talk will give a brief summary of recent progress, current challenges and a view of the path ahead.

  16. Current Status of Mechanical Circulatory Support: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Kyriakos Spiliopoulos

    2012-01-01

    Full Text Available Heart failure is a major public health problem and its management requires a significant amount of health care resources. Even with administration of the best available medical treatment, the mortality associated with the disease remains high. As therapeutical strategies for heart failure have been refined, the number of patients suffering from the disease has expanded dramatically. Although heart transplantation still represents the gold standard therapeutical approach, the implantation of mechanical circulatory support devices (MCSDs evolved to a well-established management for this disease. The limited applicability of heart transplantation caused by a shortage of donor organs and the concurrent expand of the patient population with end-stage heart failure led to a considerable utilization of MCSDs. This paper outlines the current status of mechanical circulatory support.

  17. Current status of PHOBOS at sign RHIC

    International Nuclear Information System (INIS)

    Betts, R.R.; Univ. of Illinois, Chicago, IL

    1996-01-01

    Four experiments are currently approved for the first measurements with colliding heavy ion beams from the Relativistic Heavy Ion Collider (RHIC) which is scheduled to come into operation in Spring 1999. These experiments are named STAR, Phoenix, PHOBOS and Brahms. It is expected that central collisions of 100 GeV/u Au + Au at RHIC will lead to energy densities far above any so far attained in the laboratory and it is suspected and hoped that this situation will lead to qualitatively new physics perhaps associated with the creation of a large volume containing a plasma of deconfined quarks and gluons. All four experiments attempt to search for signatures of new physics through combinations of measurements of quantities such as the multiplicity of produced particles, the average transverse momentum of these particles, fluctuations in their multiplicity distribution, their flavor composition, the size scales of the volume from which they are emitted, mass shifts and changes in the decay widths of resonances which decay inside the high energy density volume etc. The PHOBOS detector addresses these issues with a Multiplicity Array which covers the pseudo-rapidity region -5.3 ≤ η ≤ 5.3 with a coverage of 85% of 4π and also incorporates a Vertex Detector. The Multiplicity Array is complemented by two Multi-Particle Spectrometers, each of which cover the range 0.5 ≤ η ≤ 1.5 and azimuthal angle range Δφ = 11 degree. Various trigger and monitor detectors complete PHOBOS

  18. Advanced radiation chemistry research: Current status

    International Nuclear Information System (INIS)

    1995-10-01

    Radiation chemistry is a branch of chemistry that studies chemical transformations in materials exposed to high-energy radiations. It is based on the use of ionizing radiation as the initiator or catalyst in chemical reactions. The most significant advantage of radiation chemistry lies in its ability to be used in the production and study of almost any reactive atomic and molecular species playing a part in chemical reaction, synthesis, industrial processes, or in biological systems. Over the the last few years a number of meetings have taken place, under the auspices of the IAEA, in order to evaluate recent developments in radiation chemistry as well as the trends indicated by the results obtained. Radiation chemists from different countries have participated at these meetings. The present publication, a companion to the previous publication - New Trends and Development in Radiation Chemistry, IAEA-TECDOC-527 (1989) - includes some of the important contributions presented at these meetings. It is hoped that it will provide a useful overview of current activities and of emerging trends in this field, thus promoting better understanding of potential contributions of radiation chemistry to other fields of knowledge as well as to practical applications in industry, medicine and agriculture. Refs, figs and tabs

  19. Current status of endovascular catheter robotics.

    Science.gov (United States)

    Lumsden, Alan B; Bismuth, Jean

    2018-06-01

    In this review, we will detail the evolution of endovascular therapy as the basis for the development of catheter-based robotics. In parallel, we will outline the evolution of robotics in the surgical space and how the convergence of technology and the entrepreneurs who push this evolution have led to the development of endovascular robots. The current state-of-the-art and future directions and potential are summarized for the reader. Information in this review has been drawn primarily from our personal clinical and preclinical experience in use of catheter robotics, coupled with some ground-breaking work reported from a few other major centers who have embraced the technology's capabilities and opportunities. Several case studies demonstrating the unique capabilities of a precisely controlled catheter are presented. Most of the preclinical work was performed in the advanced imaging and navigation laboratory. In this unique facility, the interface of advanced imaging techniques and robotic guidance is being explored. Although this procedure employs a very high-tech approach to navigation inside the endovascular space, we have conveyed the kind of opportunities that this technology affords to integrate 3D imaging and 3D control. Further, we present the opportunity of semi-autonomous motion of these devices to a target. For the interventionist, enhanced precision can be achieved in a nearly radiation-free environment.

  20. The current status of the MASHA setup

    Energy Technology Data Exchange (ETDEWEB)

    Vedeneev, V. Yu., E-mail: vvedeneyev@gmail.com; Rodin, A. M.; Krupa, L.; Belozerov, A. V.; Chernysheva, E. V.; Dmitriev, S. N.; Gulyaev, A. V.; Gulyaeva, A. V.; Kamas, D. [Joint Institute for Nuclear Research, Flerov Laboratory of Nuclear Reactions (Russian Federation); Kliman, J. [Slovak Academy of Sciences, Institute of Physics (Slovakia); Komarov, A. B.; Motycak, S.; Novoselov, A. S.; Salamatin, V. S.; Stepantsov, S. V.; Podshibyakin, A. V.; Yukhimchuk, S. A. [Joint Institute for Nuclear Research, Flerov Laboratory of Nuclear Reactions (Russian Federation); Granja, C.; Pospisil, S. [Czech Technical University in Prague, Institute of Experimental and Applied Physics (Czech Republic)

    2017-11-15

    The MASHA setup designed as the mass-separator with the resolving power of about 1700, which allows mass identification of superheavy nuclides is described. The setup uses solid ISOL (Isotope Separation On-Line) method. In the present article the upgrade of some parts of MASHA are described: target box (rotating target + hot catcher), ion source based on electron cyclotron resonance, data acquisition, beam diagnostics and control systems. The upgrade is undertaken in order to increase the total separation efficiency, reduce the separation time, of the installation and working stability and make possible continuous measurements at high beam currents. Ion source efficiency was measured in autonomous regime with using calibrated gas leaks of Kr and Xe injected directly to ion source. Some results of the first experiments for production of radon isotopes using the multi-nucleon transfer reaction {sup 48}Ca+{sup 242}Pu are described in the present article. The using of TIMEPIX detector with MASHA setup for neutron-rich Rn isotopes identification is also described.

  1. The current status of the MASHA setup

    Science.gov (United States)

    Vedeneev, V. Yu.; Rodin, A. M.; Krupa, L.; Belozerov, A. V.; Chernysheva, E. V.; Dmitriev, S. N.; Gulyaev, A. V.; Gulyaeva, A. V.; Kamas, D.; Kliman, J.; Komarov, A. B.; Motycak, S.; Novoselov, A. S.; Salamatin, V. S.; Stepantsov, S. V.; Podshibyakin, A. V.; Yukhimchuk, S. A.; Granja, C.; Pospisil, S.

    2017-11-01

    The MASHA setup designed as the mass-separator with the resolving power of about 1700, which allows mass identification of superheavy nuclides is described. The setup uses solid ISOL (Isotope Separation On-Line) method. In the present article the upgrade of some parts of MASHA are described: target box (rotating target + hot catcher), ion source based on electron cyclotron resonance, data acquisition, beam diagnostics and control systems. The upgrade is undertaken in order to increase the total separation efficiency, reduce the separation time, of the installation and working stability and make possible continuous measurements at high beam currents. Ion source efficiency was measured in autonomous regime with using calibrated gas leaks of Kr and Xe injected directly to ion source. Some results of the first experiments for production of radon isotopes using the multi-nucleon transfer reaction 48Ca+242Pu are described in the present article. The using of TIMEPIX detector with MASHA setup for neutron-rich Rn isotopes identification is also described.

  2. The current status of the MASHA setup

    International Nuclear Information System (INIS)

    Vedeneev, V. Yu.; Rodin, A. M.; Krupa, L.; Belozerov, A. V.; Chernysheva, E. V.; Dmitriev, S. N.; Gulyaev, A. V.; Gulyaeva, A. V.; Kamas, D.; Kliman, J.; Komarov, A. B.; Motycak, S.; Novoselov, A. S.; Salamatin, V. S.; Stepantsov, S. V.; Podshibyakin, A. V.; Yukhimchuk, S. A.; Granja, C.; Pospisil, S.

    2017-01-01

    The MASHA setup designed as the mass-separator with the resolving power of about 1700, which allows mass identification of superheavy nuclides is described. The setup uses solid ISOL (Isotope Separation On-Line) method. In the present article the upgrade of some parts of MASHA are described: target box (rotating target + hot catcher), ion source based on electron cyclotron resonance, data acquisition, beam diagnostics and control systems. The upgrade is undertaken in order to increase the total separation efficiency, reduce the separation time, of the installation and working stability and make possible continuous measurements at high beam currents. Ion source efficiency was measured in autonomous regime with using calibrated gas leaks of Kr and Xe injected directly to ion source. Some results of the first experiments for production of radon isotopes using the multi-nucleon transfer reaction "4"8Ca+"2"4"2Pu are described in the present article. The using of TIMEPIX detector with MASHA setup for neutron-rich Rn isotopes identification is also described.

  3. Current status of tritium calorimetry at TLK

    Energy Technology Data Exchange (ETDEWEB)

    Buekki-Deme, A.; Alecu, C.G.; Kloppe, B.; Bornschein, B. [Institute of Technical Physics, Tritium Laboratory Karsruhe - TLK, Karlsruhe Institute of Technology - KIT, Karlsruhe (Germany)

    2015-03-15

    Inside a tritium facility, calorimetry is an important analytical method as it is the only reference method for accountancy (it is based on the measurement of the heat generated by the radioactive decay). Presently, at Tritium Laboratory Karlsruhe (TLK), 4 calorimeters are in operation, one of isothermal type and three of inertial guidance control type (IGC). The volume of the calorimeters varies between 0.5 and 20.6 liters. About two years ago we started an extensive work to improve our calorimeters with regard to reliability and precision. We were forced to upgrade 3 of our 4 calorimeters due to the outdated interfaces and software. This work involved creating new LabView programs driving the devices, re-tuning control loops and replacing obsolete hardware components. In this paper we give a review on the current performance of our calorimeters, comparing it to recently available devices from the market and in the literature. We also show some ideas for a next generation calorimeter based on experiences with our IGC calorimeters and other devices reported in the literature. (authors)

  4. Advanced radiation chemistry research: Current status

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    Radiation chemistry is a branch of chemistry that studies chemical transformations in materials exposed to high-energy radiations. It is based on the use of ionizing radiation as the initiator or catalyst in chemical reactions. The most significant advantage of radiation chemistry lies in its ability to be used in the production and study of almost any reactive atomic and molecular species playing a part in chemical reaction, synthesis, industrial processes, or in biological systems. Over the the last few years a number of meetings have taken place, under the auspices of the IAEA, in order to evaluate recent developments in radiation chemistry as well as the trends indicated by the results obtained. Radiation chemists from different countries have participated at these meetings. The present publication, a companion to the previous publication - New Trends and Development in Radiation Chemistry, IAEA-TECDOC-527 (1989) - includes some of the important contributions presented at these meetings. It is hoped that it will provide a useful overview of current activities and of emerging trends in this field, thus promoting better understanding of potential contributions of radiation chemistry to other fields of knowledge as well as to practical applications in industry, medicine and agriculture. Refs, figs and tabs.

  5. Current status of the PBMR licensing project

    International Nuclear Information System (INIS)

    Mysen, A.; Clapisson, G.A.; Metcalf, P.E.

    2000-01-01

    The CNS is currently reviewing the PBMR conceptual design from a licensibility point of view. The PBMR concept is based on a High Temperature Gas Cooled Reactor - pebble bed reactor type. It is anticipated that the PBMR design will rely on inherent safety characteristics to contain fission products within fuel over the full range of design basis events. This feature combined with the high temperature integrity of the fuel and structural graphite, allows the safe use of a high coolant temperature, which allows consideration of the future development of this reactor for non-electrical applications of nuclear heat for industrial use. The CNS licensing approach requires that the licensing and design basis of the plant should respect prevailing international norms and practices and that a quantitative risk assessment should demonstrate compliance with the CNS fundamental safety standards. The first stage of the licensing process is now ongoing; this is a pre-application phase, which will result in a statement on licensibility being issued. Identification of the specific documentation requirements and information needed is required across every step of the licensing process. Top level regulatory requirements have been established for the PBMR. They include the CNS fundamental safety standard and basic licensing criteria, which describes requirements on licensees of nuclear installations regarding risk assessment and compliance with the safety criteria and define classification of licensing basis events. (author)

  6. Biologic resurfacing of the patella: current status.

    Science.gov (United States)

    Scapinelli, Raphaele; Aglietti, Paolo; Baldovin, Marino; Giron, Francesco; Teitge, Robert

    2002-07-01

    The techniques of biologic resurfacing of the patella, like other joint surfaces, are still evolving. Currently none of them is free from criticism. In this regard it is our hope that progress in the basic science will offer in the near future new and more optimistic therapeutic possibilities (i.e., the restoration of a reparative cartilage that is structurally and functionally comparable to the native one). The greater expectancies come perhaps from the present experimental investigations about the combined use of tissue-engineered implants embedded with staminal cells and growth factors. Many problems remain to be solved, however, before reliable applicability in humans. From a general point of view, stem cells obtained from various sources (e.g., adult bone marrow, umbilical cord) offer the same finalities as the embryonic stem cells, without the ethical obstacles related to the latter. Therefore, it may be that restoration of part or all of the articular surface of a joint will be possible by way of these mesenchymal progenitors that have the ability to differentiate into the chondrogenic and osteogenic lines, which is required for the restoration of the various layers of a normal articular cartilage and subchondral bone.

  7. Current Status of Engineering Education in America

    Science.gov (United States)

    Barr, Ronald E.

    Many faculty believe that engineering education in America is at a crossroads and much change is needed. International competition in engineering and the global economy have major potential impact on the engineering workforce of the future. We must find ways to educate U.S. engineers to be competitive and creative contributors in the worldwide arena. Recent national reports are sounding the alarm that the U.S. is losing it leadership in technology and innovation, with consequences for economic prosperity and national security. The report Rising Above the Gathering Storm discusses this dilemma in detail and offers four recommendations to U.S. policymakers. The report Educating the Engineer of 2020 discusses new ways to prepare American engineers for the 21st Century. Furthermore, changes in ABET accreditation, along with new paradigms of teaching and new technology in the classroom, are changing the scholarship of engineering education. We must find ways to promote change in engineering faculty for this new opportunity in engineering educational scholarship. Future engineering students are now in K-12, which is becoming an increasingly diverse population that in the past has not been fully represented in engineering education. Current trends show disaffection for pursuing studies in science and engineering in the youth of our U.S. society. We must find new ways to portray engineering as an exciting and rewarding career, and certainly as an educational platform for professional careers beyond the baccalaureate degree.

  8. Current status of tritium calorimetry at TLK

    International Nuclear Information System (INIS)

    Buekki-Deme, A.; Alecu, C.G.; Kloppe, B.; Bornschein, B.

    2015-01-01

    Inside a tritium facility, calorimetry is an important analytical method as it is the only reference method for accountancy (it is based on the measurement of the heat generated by the radioactive decay). Presently, at Tritium Laboratory Karlsruhe (TLK), 4 calorimeters are in operation, one of isothermal type and three of inertial guidance control type (IGC). The volume of the calorimeters varies between 0.5 and 20.6 liters. About two years ago we started an extensive work to improve our calorimeters with regard to reliability and precision. We were forced to upgrade 3 of our 4 calorimeters due to the outdated interfaces and software. This work involved creating new LabView programs driving the devices, re-tuning control loops and replacing obsolete hardware components. In this paper we give a review on the current performance of our calorimeters, comparing it to recently available devices from the market and in the literature. We also show some ideas for a next generation calorimeter based on experiences with our IGC calorimeters and other devices reported in the literature. (authors)

  9. Molecular Cancer Prevention: Current Status & Future Directions

    Science.gov (United States)

    Maresso, Karen Colbert; Tsai, Kenneth Y.; Brown, Powel H.; Szabo, Eva; Lippman, Scott; Hawk, Ernest

    2016-01-01

    The heterogeneity and complexity of advanced cancers strongly supports the rationale for an enhanced focus on molecular prevention as a priority strategy to reduce the burden of cancer. Molecular prevention encompasses traditional chemopreventive agents as well as vaccinations and therapeutic approaches to cancer-predisposing conditions. Despite challenges to the field, we now have refined insights into cancer etiology and early pathogenesis; successful risk assessment and new risk models; agents with broad preventive efficacy (e.g., aspirin) in common chronic diseases, including cancer; and a successful track record of more than 10 agents approved by the FDA for the treatment of precancerous lesions or cancer risk reduction. The development of molecular preventive agents does not differ significantly from the development of therapies for advanced cancers, yet has unique challenges and special considerations given that it most often involves healthy or asymptomatic individuals. Agents, biomarkers, cohorts, overall design, and endpoints are key determinants of molecular preventive trials, as with therapeutic trials, although distinctions exist for each within the preventive setting. Progress in the development and evolution of molecular preventive agents has been steadier in some organ systems, such as breast and skin, than in others. In order for molecular prevention to be fully realized as an effective strategy, a number of challenges to the field must be addressed. Here we provide a brief overview of the context for and special considerations of molecular prevention along with a discussion of the results of major randomized controlled trials. PMID:26284997

  10. Current status of studies on nodular corrosion

    International Nuclear Information System (INIS)

    Yasuda, Takayoshi; Kawasaki, Satoru; Echigoya, Hironori; Kinoshita, Yutaka; Kubota, Hiroyuki; Konishi, Takao; Yamanaka, Tuneyasu.

    1993-01-01

    The studies on nodular corrosion formed on the outer surface of BWR fuel cladding tubes were reviewed. Main factors affecting the corrosion behavior were material and environmental conditions and combined effect. The effects of such material conditions as fabrication process, alloy elements, texture and surface treatment and environmental factors as neutron irradiation, thermo-hydrodynamic, water chemistry, purity of the coolant and contact with foreign metals on the corrosion phenomena were surveyed. Out-of-reactor corrosion test methods and models for the corrosion mechanism were also reviewed. Suppression of the accumulated annealing temperature during tube reduction process improved the nodular corrosion resistance of Zircaloys. Improved resistance for the nodular corrosion was reported for the unirradiated Zircaloys with some additives. Detailed irradiation test under the BWR conditions is needed to confirm the trend. Concerning the environmental factors, boiling on the cladding surface due to heat flux reduces the nodular corrosion susceptibility, while oxidizing radical generated from dissolved oxygen accelerates the corrosion. Concerning corrosion mechanisms, importance of such phenomena as the depleted zone of alloying elements in zirconium matrix, reduction of H + to H 2 in oxide layer, electrochemical property of precipitates, crystallographic anisotropy of oxidation rates were revealed. (author) 59 refs

  11. Current status of food irradiation in Korea

    International Nuclear Information System (INIS)

    Kwon, Joong-Ho

    2007-01-01

    With respect to the safety of irradiated food, the Korean government has accepted in principle the recommendations of international organization (FAO, WHO, IAEA, CAC, etc) as well as the national-based evaluations. Gamma radiation from Co-60 is now authorized to be used for food irradiation of 26 food items (or classes). Two multipurpose gamma-irradiation facilities (Greenpia Tech. Inc. since 1987; SOYA Co. Ltd. since 2002) are now operating for the treatments of selected food items as well as medical supplies. At present, labeled-irradiated products are not yet being marketed at the consumer level. As an alternative process of chemical fumigants, however, irradiation is being partially utilized for the microbial decontamination and pest control of dried spices, vegetable ingredients, etc. for their use in processed foods as minor ingredients. Commercial applications of food irradiation, though small in number, have been steady ever since. This article introduces the commercial progress in food irradiation technology in Korea in terms of research activities, legislation, commercialization, and the control of irradiated foods. (author)

  12. Current status of pediatric minimal access surgery at Sultan Qaboos ...

    African Journals Online (AJOL)

    Keywords: current status, laparoscopy, minimal access surgery, thoracoscopy. Departments of ... Materials and methods ... procedures, the open technique was used for the creation ... operated for bilateral inguinal herniotomy had recurrence.

  13. Current Status of On-Site Wastewater Management

    Science.gov (United States)

    Senn, Charles L.

    1978-01-01

    Wastewater management is becoming an important environmental issue nationally. This article reports the history and current status of wastewater management. Regulatory programs are discussed with specific state examples. Needs assessment is also included. (MA)

  14. International Shock-Wave Database: Current Status

    Science.gov (United States)

    Levashov, Pavel

    2013-06-01

    Shock-wave and related dynamic material response data serve for calibrating, validating, and improving material models over very broad regions of the pressure-temperature-density phase space. Since the middle of the 20th century vast amount of shock-wave experimental information has been obtained. To systemize it a number of compendiums of shock-wave data has been issued by LLNL, LANL (USA), CEA (France), IPCP and VNIIEF (Russia). In mid-90th the drawbacks of the paper handbooks became obvious, so the first version of the online shock-wave database appeared in 1997 (http://www.ficp.ac.ru/rusbank). It includes approximately 20000 experimental points on shock compression, adiabatic expansion, measurements of sound velocity behind the shock front and free-surface-velocity for more than 650 substances. This is still a useful tool for the shock-wave community, but it has a number of serious disadvantages which can't be easily eliminated: (i) very simple data format for points and references; (ii) minimalistic user interface for data addition; (iii) absence of history of changes; (iv) bad feedback from users. The new International Shock-Wave database (ISWdb) is intended to solve these and some other problems. The ISWdb project objectives are: (i) to develop a database on thermodynamic and mechanical properties of materials under conditions of shock-wave and other dynamic loadings, selected related quantities of interest, and the meta-data that describes the provenance of the measurements and material models; and (ii) to make this database available internationally through the Internet, in an interactive form. The development and operation of the ISWdb is guided by an advisory committee. The database will be installed on two mirrored web-servers, one in Russia and the other in USA (currently only one server is available). The database provides access to original experimental data on shock compression, non-shock dynamic loadings, isentropic expansion, measurements of sound

  15. Teledermatology. Current status and future directions.

    Science.gov (United States)

    Whited, J D

    2001-01-01

    Teledermatology is becoming an increasingly common means of delivering dermatologic healthcare worldwide and will almost certainly play a greater role in the future. The type of technology used distinguishes the 2 modes of teledermatology consultation. The store and forward technique uses still digital images generated by a digital camera. Consultations of this type are considered asynchronous since the images are obtained, sent, and reviewed at different times. In contrast, real-time interactive consultations are synchronous. Patients and clinicians interact in real-time through an audio-video communication link. Each modality has its advantages and disadvantages, and studies appear in the literature that assess both technologies. Although diagnostic reliability (precision) assessments for teledermatology are subject to limitations, existing information indicates that both store and forward and real-time interactive technology result in reliable diagnostic outcomes when compared with clinic-based evaluations. Less information regarding diagnostic accuracy is available; however, one evaluation that used store and forward technology found comparable diagnostic accuracy between teledermatology consultations and clinic-based examinations. Currently, little information is available regarding cost effectiveness and patient outcomes. Existing evidence, while inconclusive, suggests that teledermatology may be more costly than traditional clinic-based care, especially when using real-time interactive technology. Teledermatology has been shown to have utility as a triage mechanism for determining the urgency or need for a clinic-based consultation. Overall, patients appear to accept teledermatology and are satisfied with it as a means of obtaining healthcare. Clinicians have also generally reported positive experiences with teledermatology. Future studies that focus on cost effectiveness, patient outcomes, and patient and clinician satisfaction will help further define the

  16. Current Status on Biochip and Detection Technology

    International Nuclear Information System (INIS)

    Park, Sang Hyun; Gwon, Hui Jeong

    2007-06-01

    The recent biotechnology technique has been miniaturized and it features a fusion of electricity, electronics and mechanics in the existing biology. As an example, biochip is a collection of miniaturized test sites (microarrays) arranged on a solid substrate that permits many tests to be performed at the same time in order to achieve higher throughput and speed. Like a computer chip that can perform millions of mathematical operations in a second, the biochip can perform thousands of biological reactions, such as decoding genes, in a few seconds. The biochip is being used in toxicological, protein, and biochemical research and it can also be used to rapidly detect chemical agents used in biological warfare so that defensive measures can be taken. These biochip technologies incorporate elements of microfluidics, micromachining, synthetic chemistry, separation technologies, and detection technologies of biological molecules. Basically, biochips can be divided into two types: microarray and lab-on-a-chip system. Microarrays use planted probes to catch and identify target biological molecules while lab-on-a-chips actively process loaded samples. The biochips are becoming more diverse and customers are appearing all over the world. The products from the biochip market are being used to help accelerating the research processes and capabilities of bio-pharmaceutical drug discovery and basic academic bioresearch. To fully take advantages of the attributes of biochip technologies such as miniaturization, parallelism, automation and integration, there are some problems to overcome. The major problem is to reduce the cost. Currently the prices of biochip products are too expensive to replace traditional products and processes. As a method to solve the problem, a radioisotope can be used as a detecting sensor by appling on the biochip, as it were, radio-biochip that will further bring the cost down. The originality using the radioisotope on the biochip technology will be able

  17. Current Status on Biochip and Detection Technology

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Hyun; Gwon, Hui Jeong

    2007-06-15

    The recent biotechnology technique has been miniaturized and it features a fusion of electricity, electronics and mechanics in the existing biology. As an example, biochip is a collection of miniaturized test sites (microarrays) arranged on a solid substrate that permits many tests to be performed at the same time in order to achieve higher throughput and speed. Like a computer chip that can perform millions of mathematical operations in a second, the biochip can perform thousands of biological reactions, such as decoding genes, in a few seconds. The biochip is being used in toxicological, protein, and biochemical research and it can also be used to rapidly detect chemical agents used in biological warfare so that defensive measures can be taken. These biochip technologies incorporate elements of microfluidics, micromachining, synthetic chemistry, separation technologies, and detection technologies of biological molecules. Basically, biochips can be divided into two types: microarray and lab-on-a-chip system. Microarrays use planted probes to catch and identify target biological molecules while lab-on-a-chips actively process loaded samples. The biochips are becoming more diverse and customers are appearing all over the world. The products from the biochip market are being used to help accelerating the research processes and capabilities of bio-pharmaceutical drug discovery and basic academic bioresearch. To fully take advantages of the attributes of biochip technologies such as miniaturization, parallelism, automation and integration, there are some problems to overcome. The major problem is to reduce the cost. Currently the prices of biochip products are too expensive to replace traditional products and processes. As a method to solve the problem, a radioisotope can be used as a detecting sensor by appling on the biochip, as it were, radio-biochip that will further bring the cost down. The originality using the radioisotope on the biochip technology will be able

  18. Current status and future perspective of PET

    International Nuclear Information System (INIS)

    Lee, Myung Chul

    2002-01-01

    Positron Emission Tomography (PET) is a nuclear medicine imaging modality that consists of systemic administration to a subject of a radiopharmaceutical labeled with a positron-emitting radionuclide. Following administration, its distribution in the organ or structure under study can be assessed as a function of time and space by (1) detecting the annihilation radiation resulting from the interaction of the positrons with matter, and (2) reconstructing the distribution of the radioactivity from a series of that used in computed tomography (CT). The nuclides most generally exhibit chemical properties that render them particularly desirable in physiological studies. The radionuclides most widely used in PET are F-18, C-11, O-15 and N-13. Regarding to the number of the current PET Centers worldwide (based on ICP data), more than 300 PET Centers were in operation in 2000. The use of PET technology grew rapidly compared to that in 1992 and 1996, particularly in the USA, which demonstrates a three-fold rise in PET installations. In 2001, 194 PET Centers were operating in the USA. In 1994, two clinical and research-oriented PET Centers at Seoul National University Hospital and Samsung Medical Center, was established as the first dedicated PET and Cyclotron machines in Korea, followed by two more PET facilities at the Korea Cancer Center Hospital, Ajou Medical Center, Yonsei University Medical Center, National Cancer Center and established their PET Center. Catholic Medical School and Pusan National University Hospital have finalized a plan to install PET machine in 2002, which results in total of nine PET Centers in Korea. Considering annual trends of PET application in four major PET centers in Korea in Asan Medical Center recent six years (from 1995 to 2000), a total of 11,564 patients have been studied every year and the number of PET studies has shown steep growth year upon year. We had, 1,020 PET patients in 1995. This number increased to 1,196, 1,756, 2,379, 3

  19. Current status of treatment for diverticulitis

    NARCIS (Netherlands)

    van de Wall, Bryan Joost Marinus

    2013-01-01

    Diverticula are outpouchings that occur at week points in the colonic wall where small blood vessels enter the circular muscle layer. Diverticula are most frequently found in the distal part of the colon, with 90% of patients having the sigmoid colon involved. Most patients who have diverticulosis

  20. The current status of HANARO utilization

    International Nuclear Information System (INIS)

    Kim, Hark Rho; Lee, Choong Sung; Sohn, Jae Min; Park, Kyung Bae

    2003-01-01

    The HANARO (High-flux Advanced Neutron Application Research Reactor) is now operating at 24 MW to meet the user's demands in a variety of utilization fields. The most active field is the neutron scattering and diffraction using the currently available HRPD (High Resolution Powder Diffraction), FCD (Four Circle Diffraction), RSI (Residual Stress Instrument), and SANS (Small Angle Neutron Scattering). Using these instruments, we have been investigating such characteristics as materials' crystal structure and phase transition, residual stress, texture, and hard and soft matters. Through examination and inspection of the test specimens, NRF (Neutron Radiography Facility) is contributing to such fields as the nuclear industry, ordnance industry, aerospace industry, and archaeology. The second utilization field is the fuel and material irradiation test. KAERI (Korea Atomic Energy Research Institute) has developed atomized fuel powder and provided it to USA, France and Argentina. Under the RERTR program, KAERI has been contributing to the development of research reactor fuels of better quality. To test the reactor materials and fuels, instrumented and non-instrumented capsules are widely being used. To produce and supply RIs and pharmaceuticals for medical and industrial purposes, HANARO and its RIPF (Radioisotope Production Facility) has been fully complying with demands so that the national welfare might be enhanced by our efforts. NAA (Neutron Activation Analysis) is assisting the nuclear industry, environmental research and the promotion of the health area. To support all active utilizations, HANARO operators have been making every effort to not only improve the systems, if needed, but also to avoid the inadvertent reactor trip. Based upon this stable neutron supply, we have been developing and expanding the utilization fields and facilities. The PNS(Polarized Neutron Spectrometer) is under construction and the reflectometer is in preparation. The BNCT(Boron Neutron

  1. Ceramic materials for SOFCs: Current status

    Directory of Open Access Journals (Sweden)

    Kozhukharov, V.

    2002-10-01

    Full Text Available It is well known that the main parts of Solid Oxide Fuel Cells (SOFCs are build from ceramic materials. Namely the ceramic materials and composites, used for SOFCs manufacturing, are objects of the overview in the present work. The analysis carried out covers the last current publications in the field discussed. Special attention and examination in details have been done on patents state-of-the-art. After a background and short classification of the ceramic SOFCs materials the attention is focused on cathode, electrolyte, anode, interconnection and sealing materials. Their requirements, structure, thermal stability, composition control and behavior, processing and performance are the object of overview. A correlation has been made between the phase diagrams oxygen incorporation and transport, and SOFC advantages, generally for materials of lanthanum- base perovskite family. In order to analyze the innovative investigations regarding the patent branch of the SOFCs development and application, an object of review was patents from Japan, USA, Germany and European Union. Some examples of the inventions with accent on the ceramic materials are shown. In addition the tendency regarding R & D activities of SOFCs development materials from the leading companies in the world is analyzed. On the base of the most important technological and economical parameters of cell cathode/electrolyte/anode materials an attempt for evaluation and correlation has been made and innovative conceptions are shown.

    Es bien sabido que los componentes principales de las celdas de combustible de óxido sólido (SOFCs estan constituidos por materiales cerámicos. Dichos materiales cerámicos y materiales compuestos que se utilizan en la fabricación de SOFCs son objeto de estudio en el presente trabajo. El análisis llevado a cabo incluye la revisión de las últimas publicaciones en la materia, con una especial atención y examen minucioso sobre las patentes m

  2. Current status of cerebral glioma surgery in China.

    Science.gov (United States)

    Wu, Jin-song; Zhang, Jie; Zhuang, Dong-xiao; Yao, Cheng-jun; Qiu, Tian-ming; Lu, Jun-feng; Zhu, Feng-ping; Mao, Ying; Zhou, Liang-fu

    2011-09-01

    The treatment of gliomas is highly individualized. Surgery for gliomas is essentially for histological diagnosis, to alleviate mass effect, and most importantly, to favor longer survival expectancy. During the past two decades, many surgical techniques and adjuvants have been applied to glioma surgery in China, which lead to a rapid development in the field of cerebral glioma surgery. This article broadly and critically reviewed the existing studies on cerebral glioma surgery and to portrait the current status of glioma surgery in China. A literature search was conducted covering major innovative surgical techniques and adjuvants for glioma surgery in China. The following databases were searched: the Pubmed (January 1995 to date); China Knowledge Resource Integrated Database (January 1995 to date) and VIP Database for Chinese Technical Periodicals (January 1995 to date). A selection criterion was established to exclude duplicates and irrelevant studies. The outcome measures were extracted from included studies. A total of 3307 articles were initially searched. After excluded by abstracts and full texts, 69 studies conducted in the mainland of China were included and went through further analysis. The philosophy of surgical strategies for cerebral gliomas in China is undergoing tremendous change. Nowadays Chinese neurosurgeons pay more attention to the postoperative neurofunctional status of the patients. The aim of the glioma surgery is not only the more extensive tumor resection but also the maximal safety of intervention. The well balance of longer overall survival and higher quality of life should be judged with respect to each individual patient.

  3. Current treatment of vesicular lithiasis

    International Nuclear Information System (INIS)

    Garcia Rodriguez, Oscar

    2010-01-01

    Surgical treatment of vesicular lithiasis has changed in past years. The addition of the new techniques in daily medical practice not always is immediate. Reasons relative to when to operate a patient presenting with gall bladder calculi are argued and documenting how this procedure is mainly reserved for symptomatic patients where pain is considered as a symptom par excellence. Also, it is exposed how this change has been faced. (author)

  4. Helicopter Rotor Noise Prediction: Background, Current Status, and Future Direction

    Science.gov (United States)

    Brentner, Kenneth S.

    1997-01-01

    Helicopter noise prediction is increasingly important. The purpose of this viewgraph presentation is to: 1) Put into perspective the recent progress; 2) Outline current prediction capabilities; 3) Forecast direction of future prediction research; 4) Identify rotorcraft noise prediction needs. The presentation includes an historical perspective, a description of governing equations, and the current status of source noise prediction.

  5. Lung cancer: Current status and prospects for the future

    International Nuclear Information System (INIS)

    Mountain, C.F.; Carr, D.T.

    1986-01-01

    This book contains 32 papers. Some of the titles are: Activation of cellular ras genes in human neoplasms; The valve of definitive radiation therapy of unresectable squamous cell carcinoma, large cell carcinoma, and adenocarcinoma of the lung; Current concepts of chemotherapy and radiotherapy for small cell lung cancer, and Current status of immunotherapy for lung cancer

  6. Current status of surrogacy in Japan and uterine transplantation research.

    Science.gov (United States)

    Kisu, Iori; Banno, Kouji; Mihara, Makoto; Iida, Takuya; Yoshimura, Yasunori

    2011-10-01

    Recent advances in assisted reproductive technology (ART) have made it possible to circumvent many causes of male and female infertility. The right to have a child by ART has been respected for infertile couples. However, there are currently no legal regulations concerning ART in Japan, and this has resulted in social and ethical problems. Surrogacy involves particularly complex medical, ethical, social, and legal issues, and is frequently focused on as a major social concern. Uterine transplantation (UTx) is a potential alternative for young women with uterine factor infertility due to hysterectomy for treatment of a malignant uterine tumor or massive blood loss after delivery, or because of a congenital disease such as Mayer-Rokitansky-Küster syndrome. UTx has been examined in experimental animals as a basis for establishment of fecundity for young women with uterine factor infertility. In this review, we focus on surrogacy in Japan and UTx research, and discuss the current status and concerns in this field. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  7. Current Status and Research into Overcoming Limitations of Capsule Endoscopy

    Directory of Open Access Journals (Sweden)

    Won Gun Kwack

    2016-01-01

    Full Text Available Endoscopic investigation has a critical role in the diagnosis and treatment of gastrointestinal (GI diseases. Since 2001, capsule endoscopy (CE has been available for small-bowel exploration and is under continuous development. During the past decade, CE has achieved impressive improvements in areas such as miniaturization, resolution, and battery life. As a result, CE is currently a first-line tool for the investigation of the small bowel in obscure gastrointestinal bleeding and is a useful alternative to wired enteroscopy. Nevertheless, CE still has several limitations, such as incomplete examination and limited diagnostic and therapeutic capabilities. To resolve these problems, many groups have suggested several models (e.g., controlled CO2 insufflation system, magnetic navigation system, mobile robotic platform, tagging and biopsy equipment, and targeted drug-delivery system, which are in development. In the near future, new technological advances will improve the capabilities of CE and broaden its spectrum of applications not only for the small bowel but also for the colon, stomach, and esophagus. The purpose of this review is to introduce the current status of CE and to review the ongoing development of solutions to address its limitations.

  8. Current status and progress of pancreatic cancer in China.

    Science.gov (United States)

    Lin, Quan-Jun; Yang, Feng; Jin, Chen; Fu, De-Liang

    2015-07-14

    Cancer is currently one of the most important public health problems in the world. Pancreatic cancer is a fatal disease with poor prognosis. As in most other countries, the health burden of pancreatic cancer in China is increasing, with annual mortality rates almost equal to incidence rates. The increasing trend of pancreatic cancer incidence is more significant in the rural areas than in the urban areas. Annual diagnoses and deaths of pancreatic cancer in China are now beyond the number of cases in the United States. GLOBOCAN 2012 estimates that cases in China account for 19.45% (65727/337872) of all newly diagnosed pancreatic cancer and 19.27% (63662/330391) of all deaths from pancreatic cancer worldwide. The population's growing socioeconomic status contributes to the rapid increase of China's proportional contribution to global rates. Here, we present an overview of control programs for pancreatic cancer in China focusing on prevention, early diagnosis and treatment. In addition, we describe key epidemiological, demographic, and socioeconomic differences between China and developed countries. Facts including no nationwide screening program for pancreatic cancer, delay in early detection resulting in a late stage at presentation, lack of awareness of pancreatic cancer in the Chinese population, and low investment compared with other cancer types by government have led to backwardness in China's pancreatic cancer diagnosis and treatment. Finally, we suggest measures to improve health outcomes of pancreatic cancer patients in China.

  9. Current status of accelerator-based boron neutron capture therapy

    International Nuclear Information System (INIS)

    Kreiner, A. J.; Bergueiro, J.; Di Paolo, H.; Castell, W.; Vento, V. Thatar; Cartelli, D.; Kesque, J.M.; Valda, A.A.; Ilardo, J.C.; Baldo, M.; Erhardt, J.; Debray, M.E.; Somacal, H.R.; Estrada, L.; Sandin, J.C. Suarez; Igarzabal, M.; Huck, H.; Padulo, J.; Minsky, D.M.

    2011-01-01

    The direct use of proton and heavy ion beams for radiotherapy is a well established cancer treatment modality, which is becoming increasingly widespread due to its clear advantages over conventional photon-based treatments. This strategy is suitable when the tumor is spatially well localized. Also the use of neutrons has a long tradition. Here Boron Neutron Capture Therapy (BNCT) stands out, though on a much smaller scale, being a second-generation promising alternative for tumors which are diffuse and infiltrating. On this sector, so far only nuclear reactors have been used as neutron sources. In this paper we describe the current situation worldwide as far as the use of accelerator-based neutron sources for BNCT is concerned (so-called Accelerator-Based (AB)-BNCT). In particular we discuss the present status of an ongoing project to develop a folded Tandem-ElectroStatic-Quadrupole (TESQ) accelerator at the Atomic Energy Commission of Argentina. The project goal is a machine capable of delivering 30 mA of 2.4 MeV protons to be used in conjunction with a neutron production target based on the 7 Li(p,n) 7 Be reaction. These are the specifications needed to produce sufficiently intense and clean epithermal neutron beams to perform BNCT for deep-seated tumors in less than an hour. (author)

  10. Acute stroke magnetic resonance imaging: current status and future perspective

    International Nuclear Information System (INIS)

    Kloska, Stephan P.; Wintermark, Max; Engelhorn, Tobias; Fiebach, Jochen B.

    2010-01-01

    Cerebral stroke is one of the most frequent causes of permanent disability or death in the western world and a major burden in healthcare system. The major portion is caused by acute ischemia due to cerebral artery occlusion by a clot. The minority of strokes is related to intracerebral hemorrhage or other sources. To limit the permanent disability in ischemic stroke patients resulting from irreversible infarction of ischemic brain tissue, major efforts were made in the last decade. To extend the time window for thrombolysis, which is the only approved therapy, several imaging parameters in computed tomography and magnetic resonance imaging (MRI) have been investigated. However, the current guidelines neglect the fact that the portion of potentially salvageable ischemic tissue (penumbra) is not dependent on the time window but the individual collateral blood flow. Within the last years, the differentiation of infarct core and penumbra with MRI using diffusion-weighted images (DWI) and perfusion imaging (PI) with parameter maps was established. Current trials transform these technical advances to a redefined patient selection based on physiological parameters determined by MRI. This review article presents the current status of MRI for acute stroke imaging. A special focus is the ischemic stroke. In dependence on the pathophysiology of cerebral ischemia, the basic principle and diagnostic value of different MRI sequences are illustrated. MRI techniques for imaging of the main differential diagnoses of ischemic stroke are mentioned. Moreover, perspectives of MRI for imaging-based acute stroke treatment as well as monitoring of restorative stroke therapy from recent trials are discussed. (orig.)

  11. Current status and future trends of medical physics in Mexico

    Science.gov (United States)

    Azorin Nieto, J.

    2015-01-01

    Medical Physics is an area that applies the principles of physics to medicine, particularly in the prevention, diagnosis and treatment of diseases using ionizing and nonionizing radiation. The main attractive of medical physics is that it has a direct impact on the quality and safety of medical care in humans; this social component with direct implications for the population is of high value for Mexico. This paper describes the concepts of medical physics, trends and the current status of this discipline as a profession, which is directly related to the efforts of clinical research. It is also described what is, in my opinion, the future of medical physics in Mexico, emphasizing the fact that this field requires a substantial boost from universities and hospitals to recruit highly qualified young medical physicists and the support from government agencies such as Secretaria de Salud, Instituto Mexicano del Seguro Social and Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado through clinical research projects that allow the necessary evolution of medical physics into the hospital setting.

  12. Current status and future trends of medical physics in Mexico

    International Nuclear Information System (INIS)

    Nieto, J Azorin

    2015-01-01

    Medical Physics is an area that applies the principles of physics to medicine, particularly in the prevention, diagnosis and treatment of diseases using ionizing and nonionizing radiation. The main attractive of medical physics is that it has a direct impact on the quality and safety of medical care in humans; this social component with direct implications for the population is of high value for Mexico. This paper describes the concepts of medical physics, trends and the current status of this discipline as a profession, which is directly related to the efforts of clinical research. It is also described what is, in my opinion, the future of medical physics in Mexico, emphasizing the fact that this field requires a substantial boost from universities and hospitals to recruit highly qualified young medical physicists and the support from government agencies such as Secretaria de Salud, Instituto Mexicano del Seguro Social and Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado through clinical research projects that allow the necessary evolution of medical physics into the hospital setting

  13. Current global status of carotid artery stent placement.

    Science.gov (United States)

    Wholey, M H; Wholey, M; Bergeron, P; Diethrich, E B; Henry, M; Laborde, J C; Mathias, K; Myla, S; Roubin, G S; Shawl, F; Theron, J G; Yadav, J S; Dorros, G; Guimaraens, J; Higashida, R; Kumar, V; Leon, M; Lim, M; Londero, H; Mesa, J; Ramee, S; Rodriguez, A; Rosenfield, K; Teitelbaum, G; Vozzi, C

    1998-05-01

    Our purpose was to review the current status of carotid artery stent placement throughout the world. Surveys were sent to major interventional centers in Europe, North and South America, and Asia. Information from peer-reviewed journals was also included and supplemented the survey. The survey asked various questions regarding the patients enrolled, procedure techniques, and results of carotid stenting, including complications and restenosis. Of the centers which were sent surveys, 24 responded. The total number of endovascular carotid stent procedures that have been performed worldwide to date included 2,048 cases, with a technical success of 98.6%. Complications that occurred during carotid stent placement or within a 30-day period following placement were recorded. Overall, there were 63 minor strokes, with a rate of occurrence of 3.08%. The total number of major strokes was 27, for a rate of 1.32%. There were 28 deaths within a 30-day postprocedure period, resulting in a mortality rate of 1.37%. Restenosis rates of carotid stenting have been 4.80% at 6 mo. Endovascular stent treatment of carotid artery atherosclerotic disease is growing as an alternative to vascular surgery, especially for patients that are at high risk for standard carotid endarterectomy. The periprocedural risks for major and minor strokes and death are generally acceptable at this early stage of development.

  14. Current Status of Manufacturing Hazardous Waste in Shanghai

    Institute of Scientific and Technical Information of China (English)

    Liu Changqing; Zhang Jiangshan; Zhao Youcai

    2007-01-01

    It is difficult to manage the manufacturing hazardous waste(MHW)whichis generated from a huge amount of complicated sources and causes very serious pollution.Therefore more and more attention has been paid to MHW pollution.shanghai,as an industrial and economic center and an intemational metropolis in China,has a vast industrial system spanning a multitude of sectors,which generates MHW not only in a huge magnitude but also in a large variety of types from complicated sourrces,resulting in severe pollution.In 2003,the production of MHW in Shanghai is about 3.96 x 10ton,involving 33 indices.Most of MHW in Shanghai is treated and disposed of,but a significant portion is not handled properly and effectively.This paper carries out in-field investigation on the current status of MHW production and treat ment in Shanghai,and puts forward scientific proposals that Shanghai should facilitate cleaner production and minimize haz ardous waste;strictly enforce hazardous waste registration system, strengthen monitoring the certified enterprises;strengthen intent disposal center construction and realize hazardous waste reclamation;accelerate establishing tlle technical criteria and the management policy,promote the research and development on the treatment and disposal technology,and strengthen information management,thus realizing integrated management on MHW pollution.

  15. Current status of animal welfare and animal rights in China.

    Science.gov (United States)

    Lu, Jiaqi; Bayne, Kathryn; Wang, Jianfei

    2013-11-01

    In the past few years, new social passions have sparked on the Chinese mainland. At the centre of these burgeoning passions is a focus on animal welfare, animal treatment, and even animal rights, by the public and academic sectors. With China's rapid economic changes and greater access to information from around the world, societal awareness of animal issues is rising very fast. Hastening this paradigm shift were several highly public incidents involving animal cruelty, including exposés on bear bile harvesting for traditional Chinese medicine, the thousands of dogs rescued from China's meat trade, and the call to boycott shark fin soup and bird nest soup. This article outlines the current status of campaigning by animal advocates in China (specifically the animal rights movement) from three interlinked perspectives: wildlife conservation, companion animal protection, and laboratory animal protection. By reviewing this campaigning, we attempt to present not only the political and social impact of the concept of animal rights, but also the perceptions of, and challenges to, animal rights activities in China. 2013 FRAME.

  16. Management of reprocessed uranium. Current status and future prospects

    International Nuclear Information System (INIS)

    2007-02-01

    There is worldwide interest in developing advanced and innovative technologies for nuclear fuel cycles, minimizing waste and environmental impacts. As of the beginning of 2003, about 171000 tonnes heavy metal spent nuclear fuel is in storage, while smaller amounts have been reprocessed. In several countries, including France, India, Japan and the Russian Federation, spent fuel has been viewed as a national energy resource. Some countries hold reprocessed uranium as the result of their commercial reprocessing service contracts for reprocessing the spent fuel of others. Reprocessed uranium has a potential value for recycling either directly or after appropriate treatment. This report analyses the existing options, approaches and developments in the management of reprocessed uranium. It includes the technical issues involved in managing reprocessed uranium which are RepU arisings, storage, chemical conversion, re-enrichment, fuel fabrication, transport, reactor irradiation, subsequent reprocessing and disposal options, as well as assessment of holistic environmental impacts. The objective of this document is to overview the information on the current status and future trends in the management of RepU and to identify major issues to be considered for future projects

  17. Medical telerobotic systems: current status and future trends.

    Science.gov (United States)

    Avgousti, Sotiris; Christoforou, Eftychios G; Panayides, Andreas S; Voskarides, Sotos; Novales, Cyril; Nouaille, Laurence; Pattichis, Constantinos S; Vieyres, Pierre

    2016-08-12

    Teleoperated medical robotic systems allow procedures such as surgeries, treatments, and diagnoses to be conducted across short or long distances while utilizing wired and/or wireless communication networks. This study presents a systematic review of the relevant literature between the years 2004 and 2015, focusing on medical teleoperated robotic systems which have witnessed tremendous growth over the examined period. A thorough insight of telerobotics systems discussing design concepts, enabling technologies (namely robotic manipulation, telecommunications, and vision systems), and potential applications in clinical practice is provided, while existing limitations and future trends are also highlighted. A representative paradigm of the short-distance case is the da Vinci Surgical System which is described in order to highlight relevant issues. The long-distance telerobotics concept is exemplified through a case study on diagnostic ultrasound scanning. Moreover, the present review provides a classification into short- and long-distance telerobotic systems, depending on the distance from which they are operated. Telerobotic systems are further categorized with respect to their application field. For the reviewed systems are also examined their engineering characteristics and the employed robotics technology. The current status of the field, its significance, the potential, as well as the challenges that lie ahead are thoroughly discussed.

  18. Current status of accreditation for drug testing in hair.

    Science.gov (United States)

    Cooper, Gail; Moeller, Manfred; Kronstrand, Robert

    2008-03-21

    At the annual meeting of the Society of Hair Testing in Vadstena, Sweden in 2006, a committee was appointed to address the issue of guidelines for hair testing and to assess the current status of accreditation amongst laboratories offering drug testing in hair. A short questionnaire was circulated amongst the membership and interested parties. Fifty-two responses were received from hair testing laboratories providing details on the amount and type of hair tests they offered and the status of accreditation within their facilities. Although the vast majority of laboratories follow current guidelines (83%), only nine laboratories were accredited to ISO/IEC 17025 for hair testing. A significant number of laboratories reporting that they were in the process of developing quality systems with a view to accrediting their methods within 2-3 years. This study provides an insight into the status of accreditation in hair testing laboratories and supports the need for guidelines to encourage best practice.

  19. Current status and future direction of the MONK software package

    International Nuclear Information System (INIS)

    Smith, Nigel; Armishaw, Malcolm; Cooper, Andrew

    2003-01-01

    The current status of the MONK criticality software package is summarized in terms of recent and current developments and envisaged directions for the future. The areas of the discussion are physics modeling, geometry modeling, source modeling, nuclear data, validation, supporting tools and customer services. In future development plan, MONK continues to be focused on meeting the short and long-term needs of the code user community. (J.P.N.)

  20. Counseling in Malaysia: History, Current Status, and Future Trends

    Science.gov (United States)

    See, Ching Mey; Ng, Kok-Mun

    2010-01-01

    This article presents an overview of the history of counseling in Malaysia, provides an update of its current status, and discusses some anticipated future trends for the profession in light of recent developments in the country. Counseling in Malaysia began with school guidance in the 1960s and has now achieved recognition as a profession in…

  1. The nonparametric bootstrap for the current status model

    NARCIS (Netherlands)

    Groeneboom, P.; Hendrickx, K.

    2017-01-01

    It has been proved that direct bootstrapping of the nonparametric maximum likelihood estimator (MLE) of the distribution function in the current status model leads to inconsistent confidence intervals. We show that bootstrapping of functionals of the MLE can however be used to produce valid

  2. Current status of quantitative rotational spectroscopy for atmospheric research

    Science.gov (United States)

    Drouin, Brian J.; Wlodarczak, Georges; Colmont, Jean-Marcel; Rohart, Francois

    2004-01-01

    Remote sensing of rotational transitions in the Earth's atmosphere has become an important method for the retrieval of geophysical temperatures, pressures and chemical composition profiles that requires accurate spectral information. This paper highlights the current status of rotational data that are useful for atmospheric measurements, with a discussion of the types the rotational lineshape measurements that are not generally available in either online repository.

  3. Current Status of Single-incision Laparoscopic Surgery

    DEFF Research Database (Denmark)

    Ahmed, Irfan; Ciancio, Fabio; Ferrara, Vincenzo

    2012-01-01

    Recent advances in minimally invasive surgery have centered on reducing the number of incisions required, which has led to the development of the single-incision laparoscopic technique. A panel of European single-incision laparoscopy experts met to discuss the current status of, and the future...

  4. [Current status and prospects of gene doping detection].

    Science.gov (United States)

    Wang, Wenjun; Zhang, Sichun; Xu, Jingjuan; Xia, Xinghua; Tian, Yaping; Zhang, Xinrong; Chen, Hong-Yuan

    2008-07-01

    The fast development of biotechnology promotes the development of doping. From recombinant protein to gene doping, there is a great challenge to their detection. The improvement of gene therapy and potential to enhance athletic performance open the door for gene doping. After a brief introduction of the concept of gene doping, the current status and prospects of gene doping detection are reviewed.

  5. Chemical Reaction Engineering: Current Status and Future Directions.

    Science.gov (United States)

    Dudukovic, M. P.

    1987-01-01

    Describes Chemical Reaction Engineering (CRE) as the discipline that quantifies the interplay of transport phenomena and kinetics in relating reactor performance to operating conditions and input variables. Addresses the current status of CRE in both academic and industrial settings and outlines future trends. (TW)

  6. Special Education History, Current Status and Future: India

    Science.gov (United States)

    Antony, Pavan John

    2013-01-01

    Education of all children in public schools, including those with disabilities, continues to be an unresolved issue in many countries around the globe. While education of all children is mandated by law and considered a basic human right in many countries, the current status of implementation varies. India, for example, is an ancient country that…

  7. Hardwood lumber supply chain: current status and market opportunities

    Science.gov (United States)

    Urs Buehlmann; Matthew Bumgardner; Al Schuler; Mark Barford

    2007-01-01

    The membership of the Appalachian Hardwood Manufacturers Association was surveyed in 2005 to determine the current status of large Appalachian sawmills. The primary focus was to assess the impacts of globalization on primary manufacturing, but attention was also paid to general issues affecting the hardwood lumber supply chain-from concerns over forest health and log...

  8. Current status of agricultural extension services for market oriented ...

    African Journals Online (AJOL)

    Current status of agricultural extension services for market oriented agricultural development in Ethiopia: Results from a household baseline ... Log in or Register to get access to full text downloads. ... http://dx.doi.org/10.4314/afrrev.v10i3.1.

  9. Ethiopia's emerging domestic biogas sector : Current status, bottlenecks and drivers

    NARCIS (Netherlands)

    Kamp, L.M.; Bermúdez Forn, Esteban

    2016-01-01

    Ethiopia experiences an energy and environmental crisis due to the sustained reliance on woody biomass to satisfy its energy needs. This situation could be improved by using biogas. This paper analyses the current status of the domestic biogas sector in Ethiopia and identifies barriers and

  10. Corporate Blended Learning in Portugal: Current Status and Future Directions

    Science.gov (United States)

    Marcal, Julia; Caetano, Antonio

    2010-01-01

    The aim of this study is to characterize the current status of blended learning in Portugal, given that b-learning has grown exponentially in the Portuguese market over recent years. 38 organizations (representing 68% of all institutions certified to provide distance training by the Government Labour Office--DGERT-) participated in this study. The…

  11. Current status of studies on temperature fluctuation phenomena in LMFRs

    International Nuclear Information System (INIS)

    Ohshima, H.; Muramatsu, T.; Kobayashi, J.; Yamaguchi, A.

    1994-01-01

    This paper describes the current status of studies being performed in PNC on temperature fluctuation phenomena occurring in fast reactors. The studies concentrate on four problems: thermal stratification, thermal striping, core-plenum interaction and free surface sloshing. Both experimental and analytical approaches to reveal these phenomena and to establish design and safety evaluation methods are presented together with future works. (author)

  12. Structural Learning Theory: Current Status and New Perspectives.

    Science.gov (United States)

    Scandura, Joseph M.

    2001-01-01

    Presents the current status and new perspectives on the Structured Learning Theory (SLT), with special consideration given to how SLT has been influenced by recent research in software engineering. Topics include theoretical constructs; content domains; structural analysis; cognition; assessing behavior potential; and teaching and learning issues,…

  13. The Current Status of Teachers and the Teaching Profession in ...

    African Journals Online (AJOL)

    This paper examines the current status of teachers and the teaching sector in Tanzania. It draws on experiences of teachers, parents, and students in Dar es Salaam, Iringa and Mbeya regions. Informed by the qualitative inquiry, the paper is largely empirical in character. Data was sought through interviews and document ...

  14. CMS Data Analysis: Current Status and Future Strategy

    CERN Document Server

    Innocente, V

    2003-01-01

    We present the current status of CMS data analysis architecture and describe work on future Grid-based distributed analysis prototypes. CMS has two main software frameworks related to data analysis: COBRA, the main framework, and IGUANA, the interactive visualisation framework. Software using these frameworks is used today in the world-wide production and analysis of CMS data. We describe their overall design and present examples of their current use with emphasis on interactive analysis. CMS is currently developing remote analysis prototypes, including one based on Clarens, a Grid-enabled client-server tool. Use of the prototypes by CMS physicists will guide us in forming a Grid-enriched analysis strategy. The status of this work is presented, as is an outline of how we plan to leverage the power of our existing frameworks in the migration of CMS software to the Grid.

  15. Current status of fusion-relevant covariance data

    International Nuclear Information System (INIS)

    Muir, D.W.

    1994-01-01

    The following review of the current status of formatted data covariance files and their multigroup processing is a contribution to the IAEA Advisory Group Meeting on ''Improved Evaluations and Integral Data Testing for FENDL,'' to be held at the Max-Planck-Institut fuer Plasmaphysik, Garching, Germany, 12--16 September 1994. The draft agenda of this meeting lists as Item 6 the ''assessment of present status and role of uncertainty files, their processing and sensitivity studies related to FENDL.'' We conclude that this is an important and timely topic and recommend needed actions in this field

  16. CT colonography: current status in Europe and future perspectives

    International Nuclear Information System (INIS)

    Lefere, P.; Gryspeerdt, S.; Yoshida, H.

    2007-01-01

    In this article, we review the current status of CT colonography (CTC) in Europe and future perspectives of CTC including fecal tagging and CAD. There are several large multi-centre studies that have been initiated. Fecal tagging has gradually become a prerequisite to perform state-of-the-art CTC. However, CAD for fecal-tagging CTC remains a subject for future research. (orig.)

  17. Nuclear liability legislation in Russia - current status and expected developments

    International Nuclear Information System (INIS)

    Karpov, A. E.; Borisov, D. G.

    2000-01-01

    Present report is provided by the experts of the Russian insurance business, a company member of the Russian Nuclear Pool, and not the experts of the Ministry of Atomic Energy of Russian Federation (RF Minatom). Considering the above, the following document will outline the current status of nuclear liability legislation and insurance in Russia from a viewpoint of the insurance companies and not RF Minatom. (author)

  18. Review of the current status of radiation risk estimates

    International Nuclear Information System (INIS)

    Charles, M.W.; Little, M.P.

    1988-10-01

    This report reviews the current status of radiation risk estimation for low linear energy transfer radiation. Recent statements by various national and international organisations regarding risk estimates are critically discussed. The recently published revised population risk estimates from the study of Japanese bomb survivors are also reviewed and used with some unpublished data from Japan to calculate risk figures for a general work force. (author)

  19. Marine renewable energy in China: Current status and perspectives

    OpenAIRE

    Yong-liang Zhang; Zheng Lin; Qiu-lin Liu

    2014-01-01

    Based on a general review of marine renewable energy in China, an assessment of the development status and amount of various marine renewable energy resources, including tidal energy, tidal current energy, wave energy, ocean thermal energy, and salinity gradient energy in China's coastal seas, such as the Bohai Sea, the Yellow Sea, the East China Sea, and the South China Sea, is presented. We have found that these kinds of marine renewable energy resources will play an important role in meeti...

  20. Magnetic resonance imaging in psoriatic arthritis -- update on current status and future perspectives

    DEFF Research Database (Denmark)

    Østergaard, Mikkel; Poggenborg, René Panduro

    2012-01-01

    and future development of MRI and other modern imaging modalities in PsA. This review, presented at the GRAPPA 2010 annual meeting, describes the current status of MRI in PsA, with a focus on its use in diagnosis, monitoring, and prediction of the disease course and treatment response. Important areas...... for future research are also outlined....

  1. Current status of RCA projects and strategies for future implementation

    International Nuclear Information System (INIS)

    Kim, Kyoung Pyo; Lee, Jeong Kong

    1998-12-01

    This report is intended to provide basic overall information about ways to promote technical cooperation within the framework of RCA to accelerate and coordinate cooperative activities in nuclear science and technology in Asia and the Pacific region through a thorough review on the current status and through suggesting future implementation strategies. The contents of this report include an overall introduction of RCA, guidelines and operating rules for RCA programmes, current status and future plans for RCA projects as well as the RCA vision for the next 25 years. By reviewing the current status and future implementation strategies for RCA projects, it will help to set up a national nuclear policy aimed at seeking maximum benefits from participation in RCA projects and to implement programmes for nuclear cooperation with Asian-Pacific countries. It is expected that as a lead country for the energy sector, which is one of five thematic areas for the year 1999 - 2000 cycle programmes, Korea will continue to make significant contributions towards the implementation of RCA programmes in the future. With this report, we plan to keep up with future developments as well as implement an effective cooperation with the countries in the region so that the opinion of Korea, one of the nuclear advanced countries in the region, can be fully reflected in the establishment of future plans for RCA programmes. (author). 3 refs., 5 tabs., 1 fig

  2. Current status and perspectives of cysticercosis and taeniasis in Japan.

    Science.gov (United States)

    Yamasaki, Hiroshi

    2013-02-01

    This mini-review describes recent epidemiological trends in cysticercosis and taeniasis in Japan. Some of the topics discussed herein were presented at the first symposium on "Current perspectives of Taenia asiatica researches", that was held in Osong in Chungbuk Province, South Korea, in October 2011 and organized by Prof. K. S. Eom, Chungbuk National University School of Medicine. To better understand the trends in the occurrence of cysticercosis and taeniasis in Japan, clinical cases reported in 2005 have been updated. In addition, the current status of Taenia asiatica infections successively occurring in Japan since 2010 is also discussed.

  3. The current status of imaging diagnosis of breast cancer

    International Nuclear Information System (INIS)

    Liu Fang; Tang Guangcai

    2013-01-01

    In recent years, the incidence and the mortality rate of female breast cancer in our country is increasing, Early diagnosis of breast cancer is particularly important. Precious preoperative staging in the breast cancer is advantageous for the treatment planning. Evaluating the efficacy of chemotherapy is beneficial for adjusting the follow-up plan. Imaging examination has become an important role in breast cancer management. At present, commonly used equipment include mammography, ultrasound, CT, and MRI, etc. This article reviews the present study status of these tools in diagnosis of breast cancer. A reasonable and effective choice of those tools can facilitate clinic diagnosis and treatment. (authors)

  4. Brain activation to cocaine cues and motivation/treatment status.

    Science.gov (United States)

    Prisciandaro, James J; McRae-Clark, Aimee L; Myrick, Hugh; Henderson, Scott; Brady, Kathleen T

    2014-03-01

    Motivation to change is believed to be a key factor in therapeutic success in substance use disorders; however, the neurobiological mechanisms through which motivation to change impacts decreased substance use remain unclear. Existing research is conflicting, with some investigations supporting decreased and others reporting increased frontal activation to drug cues in individuals seeking treatment for substance use disorders. The present study investigated the relationship between motivation to change cocaine use and cue-elicited brain activity in cocaine-dependent individuals using two conceptualizations of 'motivation to change': (1) current treatment status (i.e. currently receiving versus not receiving outpatient treatment for cocaine dependence) and (2) self-reported motivation to change substance use, using the Stages of Change Readiness and Treatment Eagerness Scale. Thirty-eight cocaine-dependent individuals (14 currently in treatment) completed a diagnostic assessment and an fMRI cocaine cue-reactivity task. Whole-brain analyses demonstrated that both treatment-seeking and motivated participants had lower activation to cocaine cues in a wide variety of brain regions in the frontal, occipital, temporal and cingulate cortices relative to non-treatment-seeking and less motivated participants. Future research is needed to explain the mechanism by which treatment and/or motivation impacts neural cue reactivity, as such work could potentially aid in the development of more effective therapeutic techniques for substance-dependent patients. © 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction.

  5. Challenges of implementing fibromyalgia treatment guidelines in current clinical practice.

    Science.gov (United States)

    Arnold, Lesley M; Clauw, Daniel J

    2017-09-01

    The current diagnostic and treatment pathway for patients with fibromyalgia (FM) is lengthy, complex, and characterized by multiple physician visits with an average 2-year wait until diagnosis. It is clear that effective identification and appropriate treatment of FM remain a challenge in current clinical practice. Ideally, FM management involves a multidisciplinary approach with the preferable patient pathway originating in primary care but supported by a range of health care providers, including referral to specialist care when necessary. After the publication of individual clinical studies, high-quality reviews, and meta-analyses, recently published FM treatment guidelines have transitioned from an expert consensus to an evidence-based approach. Evidence-based guidelines provide a framework for ensuring early diagnosis and timely adoption of appropriate treatment. However, for successful outcomes, FM treatments must adopt a more holistic approach, which addresses more than just pain. Impact on the associated symptoms of fatigue and cognitive problems, sleep and mood disturbances, and lowered functional status are also important in judging the success of FM therapy. Recently published guidelines recommend the adoption of a symptom-based approach to guide pharmacologic treatment. Emerging treatment options for FM may be best differentiated on the basis of their effect on comorbid symptoms that are often associated with pain (e.g. sleep disturbance, mood, fatigue). The current review discusses the most recently published Canadian guidelines and the implications of the recent European League Against Rheumatism (EULAR) recommendations, with a focus on the challenges of implementing these guidelines in current clinical practice.

  6. The current situation of treatment systems for alcoholism in Korea.

    Science.gov (United States)

    Kim, Jee Wook; Lee, Boung Chul; Kang, Tae-Cheon; Choi, Ihn-Geun

    2013-02-01

    Alcoholism is becoming one of the most serious issues in Korea. The purpose of this review article was to understand the present status of the treatment system for alcoholism in Korea compared to the United States and to suggest its developmental direction in Korea. Current modalities of alcoholism treatment in Korea including withdrawal treatment, pharmacotherapy, and psychosocial treatment are available according to Korean evidence-based treatment guidelines. Benzodiazepines and supportive care including vitamin and nutritional support are mainly used to treat alcohol withdrawal in Korea. Naltrexone and acamprosate are the drugs of first choice to treat chronic alcoholism. Psychosocial treatment methods such as individual psychotherapy, group psychotherapy, family therapy, cognitive behavior therapy, cue exposure therapy, 12-step facilitation therapy, self-help group therapy, and community-based treatment have been carried out to treat chronic alcoholism in Korea. However, current alcohol treatment system in Korea is not integrative compared to that in the United States. To establish the treatment system, it is important to set up an independent governmental administration on alcohol abuse, to secure experts on alcoholism, and to conduct outpatient alcoholism treatment programs and facilities in an open system including some form of continuing care.

  7. The current status of treatment-related severe hypoglycemia in Japanese patients with diabetes mellitus: A report from the committee on a survey of severe hypoglycemia in the Japan Diabetes Society.

    Science.gov (United States)

    Namba, Mitsuyoshi; Iwakura, Toshio; Nishimura, Rimei; Akazawa, Kohei; Matsuhisa, Munehide; Atsumi, Yoshihito; Satoh, Jo; Yamauchi, Toshimasa

    2018-03-02

    ,962 annually, of which those with severe hypoglycemia accounted for 0.34% (17). The respondent facilities accommodated a total of 2,237 patients with severe hypoglycemia annually, with the number of patients thus accommodated being 6.5 patients per site. A total of 1,171 patients were admitted for severe hypoglycemia, with the number of patients thus admitted being 4.0 per site, who accounted for 52.3% of all patients visiting annually for severe hypoglycemia. A review of the 798 case reports collected during the survey revealed that 240, 480 and 78 patients had type 1 diabetes, type 2 diabetes, and other types of diabetes, respectively; those with type 2 diabetes were shown to be significantly older (median [interquartile range], 77.0 [68.0-83.0]) than those with type 1 diabetes (54.0 [41.0-67.0]) (P higher for those with type 2 diabetes (22.0 [19.5-24.8] kg/m 2 ) than for those with type 1 diabetes (21.3 [18.9-24.0] kg/m 2 ) (P = 0.003). It was also found that the median estimated glomerular filtration rate (eGFR) was significantly lower among those with type 2 diabetes (50.6 mL [31.8-71.1]/min/1.73 m 2 ) than among those with type 1 diabetes (73.3 [53.5-91.1] mL/min/1.73 m 2 ) (P value at onset of severe hypoglycemia was shown to be 7.0 (6.3-8.1)% among all patients examined, 7.5 (6.9-8.6)% among those with type 1 diabetes, and 6.8 (6.1-7.6)% among those with type 2 diabetes, with the HbA1c value at onset of hypoglycemia being significantly lower among those with type 2 diabetes (P services for severe hypoglycemia before. Thus, the survey revealed, for the first time, the current status of treatment-related severe hypoglycemia in Japan and clearly highlights the acute need for implementing preventive measures against hypoglycemia not only through education on hypoglycemia but through optimization of antidiabetic therapy for those at high risk of severe hypoglycemia or those with a history of severe hypoglycemia. © 2018 Japan Diabetes Society (JDS). Journal of

  8. MELiSSA Food Characterization general approach and current status

    Science.gov (United States)

    Weihreter, Martin; Chaerle, Laury; Secco, Benjamin; Molders, Katrien; van der Straeten, Dominique; Duliere, Eric; Pieters, Serge; Maclean, Heather; Dochain, Denis; Quinet, Muriel; Lutts, Stanley; Graham, Thomas; Stasiak, Michael; Rondeau Vuk, Theresa; Zheng, Youbin; Dixon, Mike; Laniau, Martine; Larreture, Alain; Timsit, Michel; Aronne, Giovanna; Barbieri, Giancarlo; Buonomo, Roberta; Veronica; Paradiso, Roberta; de Pascale, Stafania; Galbiati, Massimo; Troia, A. R.; Nobili, Matteo; Bucchieri, Lorenzo; Page, Valérie; Feller, Urs; Lasseur, Christophe

    . Available MELiSSA closed environment crop growth data were used to develop a first photosynthetic model representing the basic carbon fixation mechanisms. This model will be further elaborated in the course of this study to predict yield, oxygen production and transpi-ration. As an ultimate goal the model is intended to simulate the composition of the different plant organs (root, shoot, fruit/seed or tuber) for each crop under various conditions. For the validation of this model an extensive amount of data sets are needed. Current plant growth bench test setups will provide part of the required data. To gain more precise and detailed datasets, a highly closed plant growth chamber (Plant Characterization Unit, PCU) is under development. The PCU will provide accurate mass balances for carbon, water, oxygen and other elements with statistical reliability. This reliability is achieved through a high degree of closure and environment homogeneity. The PCU will also provide data for the above described plant characterization studies. The general work approach, the current status and future steps will be illustrated.

  9. Investigation on Current Status of World Nuclear Education and Training

    International Nuclear Information System (INIS)

    Shin, J. Y.; Min, M. J.; Noh, B. C.

    2010-04-01

    All over the world, the interest of nuclear energy is increasing and the expectations of it are getting more as one of the most practical alternative energy resources. However, since 1990s, as a lot of nuclear specialists are being retired, now the problem of manpower shortage is taken into consideration for all of us and will be continued until 2011. In this point of view, the good quality of the professional nuclear training and education systems and the nuclear education centers are requested in order to breed and supply the next generation nuclear scientists and engineers. Thus, the objective of this study is to explore the current status of world nuclear education for both of nuclear power countries and potential nuclear power utilization countries in the near future. This report introduces the importance of nuclear energy, the current status of world nuclear power plants operation and the contribution of nuclear energy. Besides, it also includes the nuclear energy development plan of potential nuclear developing countries in the near future. In addition, this study also explores the nuclear training and education systems of the nuclear development countries and the current status of nuclear education in various fields such as government, industries, nuclear power plants ect. Especially, as considering the status of nuclear education classified such as Asia, the Americas, East and West Europe, the Middle East and Africa, it shows the different characteristics of nuclear education systems in each regions aimed to identify the good practices on the nuclear education systems. Finally, through observation of international cooperation and networks of the various nuclear organizations, this will be contributed to the development of nuclear education for member states and be suggested the various of the direction of development for nuclear education in Korea. The report presents in the basis of the recent status data of the world nuclear education systems collected

  10. Variación del estado nutricional durante el tratamiento antituberculoso en beneficiarios del programa PANTBC Change in nutritional status over the course of antituberculosis treatment in current and past beneficiaries of the program PANTBC

    Directory of Open Access Journals (Sweden)

    Juan Pablo Aparco

    2012-09-01

    Full Text Available Objetivos. Analizar la variación nutricional de los beneficiarios actuales y pasados del Programa de Alimentación y Nutrición al Paciente Ambulatorio con Tuberculosis y Familia (PANTBC. Materiales y métodos. Se realizó un análi-sis secundario a partir de la valoración antropométrica por medio del índice de masa corporal (IMC en beneficiarios actuales y pasados del programa PANTBC. Las mediciones se realizaron al inicio, segundo y quinto o sexto mes y se comparó la distribución del estado nutricional al inicio respecto al final (prueba de McNemar-Bowker. Resultados. Se incluyó información de 409 beneficiarios actuales y 110 beneficiarios pasados. Tanto en beneficiarios actuales como pasados se observó disminución progresiva de la condición de bajo peso (IMCObjectives. Analyze the nutritional changes among current and old beneficiaries of the Food and Nutrition Program for Outpatients with Tuberculosis and their Family (PANTBC, Spanish acronym. Materials and methods. A secondary analysis was conducted based on the anthropometric measurements with the body mass index (BMI in current and old beneficiaries of the PANTBC program. The measurements were taken at the baseline, second and fifth or sixth month, and the distribution of the nutritional status was analyzed at baseline as compared to the endpoint (McNemar-Bowker test. Results. Information about 409 current beneficiaries and 110 old beneficiaries were included. A progressive decline in low weight as well as an increase in overweight were observed in both current and old beneficiaries (IMC<18.5. The results of the third measurement showed that 57.7% of current beneficiaries who started with low weight ended up with normal weight, while 20.7% of those who started with normal weight ended up with overweight. The analysis of the nutritional status at baseline compared to the endpoint showed changes in distribution (p<0.05. Conclusions. Across the PANTBC program, there is a variation

  11. Current status of the New Antiepileptic drugs in chronic pain.

    Directory of Open Access Journals (Sweden)

    Harpreet Singh Sidhu

    2016-08-01

    Full Text Available Antiepileptic drugs (AEDs are extensively used worldwide to treat a wide range of disorders other than epilepsy, such as neuropathic pain, migraine and bipolar disorder. Due to this situation more than 20 new third-generation AEDs have been introduced in the market recently. The future design of new AEDs must also have potential to help in the non-epileptic disorders. The wide acceptance of second generation AEDs for the management of various Non-epileptic disorders has caused the emergence of generics in the market. The wide use of approved AEDs outside epilepsy is based on both economic and scientific reasons. Bipolar disorders, migraine prophylaxis, fibromyalgia and neuropathic pain represent the most attractive indication expansion opportunities for anticonvulsant developers, providing blockbuster revenues. Strong growth in non-epilepsy conditions will see Pfizer’s Lyrica become the market leading brand by 2018. In this review we mainly focus on the current status of new AEDs in the treatment of chronic pain and migraine prophylaxis. AEDs have a strong analgesic potential and this is demonstrated by the wide use of carbamazepine in trigeminal neuralgia and sodium valproate in migraine prophylaxis. At present, data on the new AEDs for non-epileptic conditions are inconclusive. Not all AEDs are effective in the management of neuropathic pain and migraine. Only those AEDs whose mechanisms of action are match with pathophysiology of the disease, have potential to show efficacy in non-epileptic disorder. For this better understanding of the pathophysiology of the disease and mechanisms of action of new AEDs are essential requirement before initiating pre-clinical and clinical trials. Many new AEDs show good results in the animal model and open-label studies but fail to provide strong evidence at randomized, placebo-controlled trials. The final decision regarding the clinical efficacy of the particular AEDs in a specific non-epileptic disorder

  12. Current status of high-T{sub c} wire

    Energy Technology Data Exchange (ETDEWEB)

    Vase, Per [Nordic Superconductor Technologies A/S, Priorparken 685, DK 2605 Broendby (Denmark); Fluekiger, Rene [Departement de Physique de la Matiere Condensee, Universite de Geneve (Switzerland); Leghissa, Martino [Siemens AG, Corporate Technology, Erlangen (Germany); Glowacki, Bartek [Department of Material Science and Metallurgy, University of Cambridge, Cambridge CB2 3QZ (United Kingdom)

    2000-07-01

    This paper is the result of the work of a SCENET (The European Network for Superconductivity) material working group's efforts on giving values for present and future expected performance of high-temperature superconducting (HTS) wires and tapes. The purpose of the work is to give input to the design of HTS applications like power cables, motors, current leads, magnets, transformers and generators. The current status performance values are supposed to be used in the design of today's prototypes and the future values for the design of fully commercial HTS applications of the future. We focus on what is expected to be the relevant parameters for HTS application design. The most successful technique by far for making HTS tapes has been on the (Bi, Pb){sub 2}Sr{sub 2}Ca{sub 2}Cu{sub 3}O{sub x} (Bi-2223) material by the powder-in-tube (PIT) technique and this paper therefore focuses on giving the current status and expected future performance for Bi-2223 tapes. (author)

  13. Indirect dark matter searches: current status and perspectives

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    Many theoretical ideas for the particle nature of dark matter exist. The  most popular models often predict that dark matter particles self-annihilate or decay, giving rise to potentially detectable signatures in astronomical observations.  I will summarize the current status of searches for such signatures and critically reassess recent claims for dark matter signals.  I will further provide an outlook on anticipated developments in the next 10 years, and discuss new methods to facilitate strategy development.

  14. Current status of large-scale cryogenic gravitational wave telescope

    International Nuclear Information System (INIS)

    Kuroda, K; Ohashi, M; Miyoki, S; Uchiyama, T; Ishitsuka, H; Yamamoto, K; Kasahara, K; Fujimoto, M-K; Kawamura, S; Takahashi, R; Yamazaki, T; Arai, K; Tatsumi, D; Ueda, A; Fukushima, M; Sato, S; Nagano, S; Tsunesada, Y; Zhu, Zong-Hong; Shintomi, T; Yamamoto, A; Suzuki, T; Saito, Y; Haruyama, T; Sato, N; Higashi, Y; Tomaru, T; Tsubono, K; Ando, M; Takamori, A; Numata, K; Aso, Y; Ueda, K-I; Yoneda, H; Nakagawa, K; Musha, M; Mio, N; Moriwaki, S; Somiya, K; Araya, A; Kanda, N; Telada, S; Tagoshi, H; Nakamura, T; Sasaki, M; Tanaka, T; Oohara, K; Takahashi, H; Miyakawa, O; Tobar, M E

    2003-01-01

    The large-scale cryogenic gravitational wave telescope (LCGT) project is the proposed advancement of TAMA, which will be able to detect the coalescences of binary neutron stars occurring in our galaxy. LCGT intends to detect the coalescence events within about 240 Mpc, the rate of which is expected to be from 0.1 to several events in a year. LCGT has Fabry-Perot cavities of 3 km baseline and the mirrors are cooled down to a cryogenic temperature of 20 K. It is planned to be built in the underground of Kamioka mine. This paper overviews the revision of the design and the current status of the R and D

  15. [Molecular imaging; current status and future prospects in USA].

    Science.gov (United States)

    Kobayashi, Hisataka

    2007-02-01

    The goal of this review is to introduce the definition, current status, and future prospects of the molecular imaging, which has recently been a hot topic in medicine and the biological science in USA. In vivo imaging methods to visualize the molecular events and functions in organs or animals/humans are overviewed and discussed especially in combinations of imaging modalities (machines) and contrast agents(chemicals) used in the molecular imaging. Next, the close relationship between the molecular imaging and the nanotechnology, an important part of nanomedicine, is stressed from the aspect of united multidisciplinary sciences such as physics, chemistry, biology, and medicine.

  16. History and current status of nuclear fuel reprocessing technology

    International Nuclear Information System (INIS)

    Funasaka, Hideyuki; Nagai, Toshihisa; Washiya, Tadahiro

    2008-01-01

    History and present state of fast breeder reactor was reviewed in series. As a history and current status of nuclear fuel reprocessing technology, this ninth lecture presented the progress of the FBR fuel reprocessing technology and advanced reprocessing processes. FBR fuel reprocessing technology had been developed to construct the reprocessing equipment test facilities (RETF) based on PUREX process technologies. With economics, reduction of environmental burdens and proliferation resistance taken into consideration, advanced aqueous method for nuclear fuel cycle activities has been promoted as the government's basic policy. Innovative technologies on mechanical disassembly, continuous rotary dissolver, crystallizer, solvent extraction and actinides recovery have been mainly studied. (T. Tanaka)

  17. Current Status of Operation and Management of Dental School Clinics.

    Science.gov (United States)

    Reinhardt, John W

    2017-08-01

    This article summarizes the current status of the operation and management of dental school clinics as schools strive to provide excellent patient-centered care in an environment that is educationally sound, efficient, and financially strong. Clinical education is a large component of dental education and an area in which many dental schools have an opportunity to enhance revenue. Clinical efficiencies and alternative models of clinical education are evolving in U.S. dental schools, and this article describes some of those evolutionary changes. This article was written as part of the project "Advancing Dental Education in the 21 st Century."

  18. CT myocardial perfusion imaging: current status and future perspectives.

    Science.gov (United States)

    Yang, Dong Hyun; Kim, Young-Hak

    2017-07-01

    Computed tomography myocardial perfusion (CTP) combined with coronary computed tomography angiography (CCTA) may constitute a "1-stop shop" for the noninvasive diagnosis of hemodynamically significant coronary stenosis during a single CT examination. CTP shows high diagnostic performance and provides incremental value over CCTA for the detection of hemodynamically significant coronary stenosis in patients with a high Agatston calcium score or coronary artery stents. Future studies should determine the optimal protocol and clinical value of CTP for guiding revascularization strategy and prognostication. In this article, we review the current status and future perspectives of CTP, focusing on technical considerations, clinical applications, and future research topics.

  19. Thermoelectric microgenerators. Current status and prospects of application

    Directory of Open Access Journals (Sweden)

    Strutynska L. T.

    2008-08-01

    Full Text Available Analysis of current status and prospects of using thermoelectric microgenerators, including organic-fueled ones, is performed. Developments of thermoelectric microgenerators presented in this review demonstrate that their increasingly wide use forms a separate, very important line of thermoelectricity – micropower generation with growing potential of practical applications for charging batteries, mobile phones, digital cameras and photocameras, power supply to small radio stations, other portable devices, including medical. The ways of increasing the efficiency of such devices and relevant lines of their wide use in practice are determined.

  20. Current status and some aspects of the future energy strategy

    International Nuclear Information System (INIS)

    Antic, D. P.; Sokcic-Kostic, M. S. . E-mail address of corresponding author: dragon@vin.bg.ac.yu; Antic, D.)

    2005-01-01

    Current status of the energy production and of the energy sources in the world, European Union, Serbia and Montenegro and the Balkan states is analyzed. Some trends in the energy consumption and productions in some European states are analyzed. Some problems of the Serbia and Montenegro energy production system are compared with situation in neighbor states, Germany, and European Union. At present, anywhere in the world, the nuclear power in on the defensive. In some countries it has been even outlawed. Some parameters show that nuclear power, on the global scale and during this century at least, is absolutely essential and reasons for revival of nuclear energy are realistic. (author)

  1. ZnO growth technologies: current status and perspectives

    International Nuclear Information System (INIS)

    Lupan, Oleg

    2011-01-01

    Development of new technologies for ZnO nano materials and thin films is of critical importance for further fundamental investigations and practical applications. We discuss on the main technical control of the synthesis of zinc oxide and its properties, which are of significance in understanding the growth mechanism and further developing ZnO-based devices. Next, we present a brief summary of recent research activities, current status and progress in developing improved control of technological processes for zinc oxide as advanced material.

  2. Current status of the nuclear medicine in Japan

    International Nuclear Information System (INIS)

    Torizuka, K.

    1974-01-01

    A brief survey of the current status of Japan nuclear medicine is given. The following data are described (from the material of the 11th Japan Conference of Radioisotopes): 1. the increase of the number of nuclear instruments between 1971 and 1973; 2. the total amount of the cobalt radiation apparatur (inclusive of the cesium apparatus) in the hospitals in 1971- and 1972; 3. the radioactive medicines and nuclids used in Japan; 4. the radioactive isotopes used generally in the therapeutics in 1971 and 1972; 5. the question of labour. (K.A.)

  3. Community-based dental education: history, current status, and future.

    Science.gov (United States)

    Formicola, Allan J; Bailit, Howard L

    2012-01-01

    This article examines the history, current status, and future direction of community-based dental education (CBDE). The key issues addressed include the reasons that dentistry developed a different clinical education model than the other health professions; how government programs, private medical foundations, and early adopter schools influenced the development of CBDE; the societal and financial factors that are leading more schools to increase the time that senior dental students spend in community programs; the impact of CBDE on school finances and faculty and student perceptions; and the reasons that CBDE is likely to become a core part of the clinical education of all dental graduates.

  4. Current status of endoscopic simulation in gastroenterology fellowship training programs.

    Science.gov (United States)

    Jirapinyo, Pichamol; Thompson, Christopher C

    2015-07-01

    Recent guidelines have encouraged gastroenterology and surgical training programs to integrate simulation into their core endoscopic curricula. However, the role that simulation currently has within training programs is unknown. This study aims to assess the current status of simulation among gastroenterology fellowship programs. This questionnaire study consisted of 38 fields divided into two sections. The first section queried program directors' experience on simulation and assessed the current status of simulation at their institution. The second portion surveyed their opinion on the potential role of simulation on the training curriculum. The study was conducted at the 2013 American Gastroenterological Association Training Directors' Workshop in Phoenix, Arizona. The participants were program directors from Accreditation Council for Graduate Medical Education accredited gastroenterology training programs, who attended the workshop. The questionnaire was returned by 69 of 97 program directors (response rate of 71%). 42% of programs had an endoscopic simulator. Computerized simulators (61.5%) were the most common, followed by mechanical (30.8%) and animal tissue (7.7%) simulators, respectively. Eleven programs (15%) required fellows to use simulation prior to clinical cases. Only one program has a minimum number of hours fellows have to participate in simulation training. Current simulators are deemed as easy to use (76%) and good educational tools (65%). Problems are cost (72%) and accessibility (69%). The majority of program directors believe that there is a need for endoscopic simulator training, with only 8% disagreeing. Additionally, a majority believe there is a role for simulation prior to initiation of clinical cases with 15% disagreeing. Gastroenterology fellowship program directors widely recognize the importance of simulation. Nevertheless, simulation is used by only 42% of programs and only 15% of programs require that trainees use simulation prior to

  5. Current Status of Dengue Therapeutics Research and Development.

    Science.gov (United States)

    Low, Jenny G H; Ooi, Eng Eong; Vasudevan, Subhash G

    2017-03-01

    Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  6. Current treatment of low grade astrocytoma

    DEFF Research Database (Denmark)

    Pedersen, Christina Louise; Romner, Bertil

    2013-01-01

    Through a comprehensive review of the current literature, the present article investigates several aspects of low grade astrocytomas (LGA), including prognostic factors, treatment strategies and follow-up regimes. LGA are in general relatively slow-growing primary brain tumours, but they have a v...... effective in discriminating between tumour progression and radiation necrosis. The research into biomarkers is currently limited with regards to their applications in LGA diagnostics, and therefore further studies including larger patient populations are needed.......Through a comprehensive review of the current literature, the present article investigates several aspects of low grade astrocytomas (LGA), including prognostic factors, treatment strategies and follow-up regimes. LGA are in general relatively slow-growing primary brain tumours, but they have...... as the course of disease. The current literature seems to support the idea that treatment with radical tumour resection, where possible, yields better long term outcome for patients with LGA. However, adjuvant therapy is often necessary. Administering early postoperative radiotherapy to patients with partially...

  7. Current Treatment of Chronic Lymphocytic Leukemia.

    Science.gov (United States)

    Jamroziak, Krzysztof; Puła, Bartosz; Walewski, Jan

    2017-01-01

    A number of new treatment options have recently emerged for chronic lymphocytic leukemia (CLL) patients, including the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, phosphatidylinositol-3-kinase (PI3K) delta isoform inhibitor idelalisib combined with rituximab, the Bcl-2 antagonist venetoclax, and the new anti-CD20 antibodies obinutuzumab and ofatumumab. Most of these agents are already included into treatment algorithms defined by international practice guidelines, but more clinical investigations are needed to answer still remaining questions. Ibrutinib was proven as a primary choice for patients with the TP53 gene deletion/mutation, who otherwise have no active treatment available. Idelalisib with rituximab is also an active therapy, but due to increased risk of serious infections, its use in first-line treatment is limited to patients for whom ibrutinib is not an option. A new indication for ibrutinib was recently approved for older patients with comorbidities, as an alternative to the already existing indication for chlorambucil with obinutuzumab. The use of kinase inhibitors is already well established in recurrent/refractory disease. Immunochemotherapy with fludarabine, cyclophosphamide, rituximab (FCR) remains a major first-line option for many CLL patients without the TP53 gene deletion/mutation, and who have no significant comorbidities or history of infections, and is particularly effective in patients with favorable features including mutated IGHV status. There are a number of issues regarding novel therapies for CLL that need further investigation such as optimum duration of treatment with kinase inhibitors, appropriate sequencing of novel agents, mechanisms of resistance to inhibitors and response to class switching after treatment failure, along with the potential role of combinations of targeted agents.

  8. Current approaches in atrial fibrillation treatment

    Directory of Open Access Journals (Sweden)

    Cenk Sarı

    2014-09-01

    Full Text Available Atrial fibrillation (AF is the most common sustained arrhythmia encountered in clinical practice. Its incidence increases with age. AF is classified into subtypes according to the duration and/or able to provide sinus rhytym. İnitially, patients should be evaluated for rhythm or rate control for appropriate treatment. Second stage of strategy aimed to investigate the feasibility of anticoagulation therapy. Recently, due to the progress made in treatment with rhythm control and anticoagulation therapy, either American or European guidelines have been renovated. These developments have taken place in the newly published guide. In this article, the current change in the management of AF is discussed.

  9. MONK and MCBEND: Current status and recent developments

    International Nuclear Information System (INIS)

    Richards, Simon D.; Baker, Chris M.J.; Bird, Adam J.; Cowan, Pat; Davies, Nigel; Dobson, Geoff P.; Fry, Tim C.; Kyrieleis, Albrecht; Smith, Paul N.

    2015-01-01

    Highlights: • We describe recent developments to the Monte Carlo codes MONK and MCBEND. • MONK is a Monte Carlo code for nuclear criticality and reactor physics analyses. • MCBEND is a Monte Carlo code for radiation shielding and dosimetry analyses. • Improvements include input; physics; scoring; variance reduction; and visualisation. • Parallelisation of MONK and multi-physics coupling are described. - Abstract: MONK® and MCBEND are Monte Carlo software packages for: nuclear criticality and reactor physics; and radiation shielding and dosimetry applications, respectively. The codes are actively developed, maintained and supported by AMEC’s ANSWERS® Software Service in line with the ANSWERS vision of providing easy-to-use software that meets the current and emerging needs of the user community. This paper summarises the current status of MONK and MCBEND and the recent developments which have been carried out to the codes, and their supporting nuclear data libraries and visualisation package

  10. Review of the current status of linear hybrid reactor concepts

    International Nuclear Information System (INIS)

    Schultz, K.R.

    1977-07-01

    A review was made of the current status of linear fusion-fission hybrid reactor design studies in the USA. The linear hybrid reactor concepts reviewed include the linear theta-pinch hybrid reactor being studied at Los Alamos Scientific Laboratory, the electron beam-heated solenoid hybrid reactor under development at Physics International Co., the laser-heated solenoid hybrid reactor being investigated at Mathematical Sciences Northwest, Inc., and the linear fusion waste burning reactor being studied at General Atomic Company. The discussion addresses confinement and heating mechanisms for each concept, as well as the hybrid blanket designs. The current state of the four reactor designs is summarized and the performance of the various concepts compared

  11. Study of Grants, new Mexico, uranium miners: current status

    International Nuclear Information System (INIS)

    Samet, J.M.; Morgan, M.V.; Buechley, R.W.; Key, C.R.; Valdivia, A.A.

    1981-01-01

    The Uranium Epidemiology Study at the University of New Mexico was initiated in 1977 with the objective of assessing health effects of uranium mining in the Grants, New Mexico, area. The planned approach was a cohort study of mortality that would capitalize on the availability of health records at the Grants Clinic. The first year's work confirmed the study's feasibility (Buechley, 1979). Subsequent efforts have focused on the health and exposure data base and comprehensive follow-up. A retrospective cohort study of early miners is in progress; a prospective cohort study of miners who began working under the current federal standard is planned. This report will summarize the current status of the Uranium Epidemiology Study

  12. Elementary particle physics and cosmology: current status and prospects

    International Nuclear Information System (INIS)

    Rubakov, Valerii A

    1999-01-01

    The current status of elementary particle physics can be briefly summarized as follows: the Standard Model of elementary particles is perfectly (at the level of radiation effects!) adequate in describing all the available experimental data except for the recent indications of neutrino oscillations. At the same time, much (and possibly most) of today's cosmology is not encompassed by the Standard Model - a fact which, together with intrinsic theoretical difficulties and the neutrino oscillation challenge, strongly indicates that the Standard Model is incomplete. It is expected that in the current decade a 'new physics', i.e. particles and interactions beyond the Standard Model, will emerge. Major advances in cosmology, both in terms of qualitatively improved observations and theoretical analysis of the structure and evolution of the Universe, are expected as well. (special issue)

  13. Current Status and Future Directions of Targeted Peptide Radionuclide Therapy

    International Nuclear Information System (INIS)

    Valkema, R.

    2009-01-01

    Current status: Peptide receptor radionuclide therapy (PRRT) is currently almost exclusively targeted at the somatostatin receptor (sst). Of the 5 receptor subtypes, sst2 is frequently very highly expressed at the cell surface of neuroendocrine tumors (NET). Octreotide is a small and stable derivative of native somatostatin, which can be very well labeled with therapeutic radionuclides such as the beta-emitters ''9''0Y, ''1''7''7Lu or the Auger emitter ''1''1''1In, chelated in DTPA or DOTA, linked to the peptide. All current therapeutic octreotide derivatives are agonists that are internalized in the cell. The affinity for the sst2 receptor is better for [DOTA,Tyr''3]octreotate than for [DOTA,Tyr''3]octreotide or [DTPA]octreotide. ''9''0Y is a pure beta-emitter, with a half-life of 2.7 days, a high energy of 2.270 MeV, and a maximum penetration in tissue of 12mm. ''1''7''7Lu with a half-life of 6.7 days emits a low abundance of gamma photons as well as beta particles of 497 keV, with a maximum tissue penetration of 2 mm. ''1''7''7Lu-[DOTA,Tyr''3]octreotate (Lu-DOTATE), ''9''0Y-[DOTA,Tyr''3]octreotate (Y-DOTATATE) and ''9''0Y-[DOTA,Tyr''3]octreotide (Y-DOTATOC) are today the most frequently used therapeutic radiopeptides. Main inclusion criteria: inoperable and/or metastatic NET, receptor-positivity in all known lesions demonstrated by sufficient uptake on ''1''1''1In-octreotide scintigraphy (intensity > liver parenchyma), life expectancy at least 3-6 months, sufficient bone marrow reserve (hemoglobin (HGB) ≥ 5 mmol/L, white blood cells (WBC) ≥ 2*10 9 /L, platelets (PLT) ≥ 75*10 12 /L), sufficient renal function (serum creatinine 40 mL/min), sufficient hepatic and cardiac reserve. Karnofski score ≥50. Efficacy: several groups have reported objective response rates (RECIST or WHO/SWOG; CT or MRI based). Complete remission (CR) is rarely seen, partial remission (PR; >50% shrinkage SWOG) in 7% - 37%, minor remission (MR, 25% - 50% shrinkage) in 13% - 17

  14. Research Experience in Psychiatry Residency Programs Across Canada: Current Status

    Science.gov (United States)

    Shanmugalingam, Arany; Ferreria, Sharon G; Norman, Ross M G; Vasudev, Kamini

    2014-01-01

    Objective: To determine the current status of research experience in psychiatry residency programs across Canada. Method: Coordinators of Psychiatric Education (COPE) resident representatives from all 17 psychiatry residency programs in Canada were asked to complete a survey regarding research training requirements in their programs. Results: Among the 17 COPE representatives, 15 completed the survey, representing 88% of the Canadian medical schools that have a psychiatry residency program. Among the 15 programs, 11 (73%) require residents to conduct a scholarly activity to complete residency. Some of these programs incorporated such a requirement in the past 5 years. Ten respondents (67%) reported availability of official policy and (or) guidelines on resident research requirements. Among the 11 programs that have a research requirement, 10 (91%) require residents to complete 1 scholarly activity; 1 requires completion of 2 scholarly activities. Eight (53%) residency programs reported having a separate research track. All of the programs have a research coordinator and 14 (93%) programs provide protected time to residents for conducting research. The 3 most common types of scholarly activities that qualify for the mandatory research requirement are a full independent project (10 programs), a quality improvement project (8 programs), and assisting in a faculty project (8 programs). Six programs expect their residents to present their final work in a departmental forum. None of the residency programs require publication of residents’ final work. Conclusions: The current status of the research experience during psychiatry residency in Canada is encouraging but there is heterogeneity across the programs. PMID:25565474

  15. Parametric overdispersed frailty models for current status data.

    Science.gov (United States)

    Abrams, Steven; Aerts, Marc; Molenberghs, Geert; Hens, Niel

    2017-12-01

    Frailty models have a prominent place in survival analysis to model univariate and multivariate time-to-event data, often complicated by the presence of different types of censoring. In recent years, frailty modeling gained popularity in infectious disease epidemiology to quantify unobserved heterogeneity using Type I interval-censored serological data or current status data. In a multivariate setting, frailty models prove useful to assess the association between infection times related to multiple distinct infections acquired by the same individual. In addition to dependence among individual infection times, overdispersion can arise when the observed variability in the data exceeds the one implied by the model. In this article, we discuss parametric overdispersed frailty models for time-to-event data under Type I interval-censoring, building upon the work by Molenberghs et al. (2010) and Hens et al. (2009). The proposed methodology is illustrated using bivariate serological data on hepatitis A and B from Flanders, Belgium anno 1993-1994. Furthermore, the relationship between individual heterogeneity and overdispersion at a stratum-specific level is studied through simulations. Although it is important to account for overdispersion, one should be cautious when modeling both individual heterogeneity and overdispersion based on current status data as model selection is hampered by the loss of information due to censoring. © 2017, The International Biometric Society.

  16. Esophageal achalasia: current diagnosis and treatment.

    Science.gov (United States)

    Schlottmann, Francisco; Patti, Marco G

    2018-05-27

    Esophageal achalasia is a primary esophageal motility disorder of unknown origin, characterized by lack of peristalsis and by incomplete or absent relaxation of the lower esophageal sphincter in response to swallowing. The goal of treatment is to eliminate the functional obstruction at the level of the gastroesophageal junction Areas covered: This comprehensive review will evaluate the current literature, illustrating the diagnostic evaluation and providing an evidence-based treatment algorithm for this disease Expert commentary: Today we have three very effective therapeutic modalities to treat patients with achalasia - pneumatic dilatation, per-oral endoscopic myotomy and laparoscopic Heller myotomy with fundoplication. Treatment should be tailored to the individual patient, in centers where a multidisciplinary approach is available. Esophageal resection should be considered as a last resort for patients who have failed prior therapeutic attempts.

  17. Current treatments for patients with Alzheimer disease.

    Science.gov (United States)

    Osborn, Gerald G; Saunders, Amanda Vaughn

    2010-09-01

    There is neither proven effective prevention for Alzheimer disease nor a cure for patients with this disorder. Nevertheless, a spectrum of biopsychosocial therapeutic measures is available for slowing progression of the illness and enhancing quality of life for patients. These measures include a range of educational, psychological, social, and behavioral interventions that remain fundamental to effective care. Also available are a number of pharmacologic treatments, including prescription medications approved by the US Food and Drug Administration for Alzheimer disease, "off-label" uses of medications to manage target symptoms, and controversial complementary therapies. Physicians must make the earliest possible diagnosis to use these treatments most effectively. Physicians' goals should be to educate patients and their caregivers, to plan long-term care options, to maximally manage concurrent illnesses, to slow and ameliorate the most disabling symptoms, and to preserve effective functioning for as long as possible. The authors review the various current treatments for patients with Alzheimer disease.

  18. Robotic technology in surgery: current status in 2008.

    Science.gov (United States)

    Murphy, Declan G; Hall, Rohan; Tong, Raymond; Goel, Rajiv; Costello, Anthony J

    2008-12-01

    There is increasing patient and surgeon interest in robotic-assisted surgery, particularly with the proliferation of da Vinci surgical systems (Intuitive Surgical, Sunnyvale, CA, USA) throughout the world. There is much debate over the usefulness and cost-effectiveness of these systems. The currently available robotic surgical technology is described. Published data relating to the da Vinci system are reviewed and the current status of surgical robotics within Australia and New Zealand is assessed. The first da Vinci system in Australia and New Zealand was installed in 2003. Four systems had been installed by 2006 and seven systems are currently in use. Most of these are based in private hospitals. Technical advantages of this system include 3-D vision, enhanced dexterity and improved ergonomics when compared with standard laparoscopic surgery. Most procedures currently carried out are urological, with cardiac, gynaecological and general surgeons also using this system. The number of patients undergoing robotic-assisted surgery in Australia and New Zealand has increased fivefold in the past 4 years. The most common procedure carried out is robotic-assisted laparoscopic radical prostatectomy. Published data suggest that robotic-assisted surgery is feasible and safe although the installation and recurring costs remain high. There is increasing acceptance of robotic-assisted surgery, especially for urological procedures. The da Vinci surgical system is becoming more widely available in Australia and New Zealand. Other surgical specialties will probably use this technology. Significant costs are associated with robotic technology and it is not yet widely available to public patients.

  19. Periodontal status and treatment needs of primary school teachers ...

    African Journals Online (AJOL)

    Periodontal status and treatment needs of primary school teachers in the absence of ... on probing, periodontal pocketing and treatment needs with CPITN and tooth ... Is In the form of oral prophylaxis and non-surgical periodontal treatment.

  20. Current status of superficial pharyngeal squamous cell carcinoma in Japan.

    Science.gov (United States)

    Rikitake, Ryoko; Ando, Mizuo; Saito, Yuki; Yoshimoto, Seiichi; Yamasoba, Tatsuya; Higashi, Takahiro

    2017-10-01

    To investigate the status and treatment of superficial pharyngeal squamous cell carcinoma in Japan. We analyzed all cases diagnosed between 2011 and 2013, as recorded in the national database of hospital-based cancer registries. We extracted data on patient sex, age, tumor locations, histology, presentation routes, initial treatments, and TNM stages. Additionally, we compared the characteristics of pharyngeal carcinoma to those of esophageal cancer. A total of 16,521 oropharyngeal and hypopharyngeal cancers from 409 institutions were included. Diagnosis of Tis tumors was infrequent, and both cancers were likely to be diagnosed at an advanced stage (n = 866, 5.3%). Tis diseases were the most commonly detected during follow-up examinations for other diseases (n = 608, 70%). While more oropharyngeal Tis patients were men compared to T1-4 patients (88 vs 82%, respectively), hypopharyngeal cancer patients comprised an equally high proportion of men (94 vs 92%, respectively). The most common location of oropharyngeal Tis tumors was the posterior wall (32%), whereas T1-4 tumors were most commonly found on the lateral wall (36%). In hypopharyngeal cancer, both Tis and T1-4 were most commonly located in the pyriform sinus (62%). The proportion of Tis tumors diagnosed at individual institutions showed a positive correlation with the number of endoscopic treatments (r = 0.32, P squamous cell carcinoma patients in Japan. Further improvements in early diagnosis and standardized treatments are warranted.

  1. Australian shellfish ecosystems: Past distribution, current status and future direction.

    Directory of Open Access Journals (Sweden)

    Chris L Gillies

    Full Text Available We review the status of marine shellfish ecosystems formed primarily by bivalves in Australia, including: identifying ecosystem-forming species, assessing their historical and current extent, causes for decline and past and present management. Fourteen species of bivalves were identified as developing complex, three-dimensional reef or bed ecosystems in intertidal and subtidal areas across tropical, subtropical and temperate Australia. A dramatic decline in the extent and condition of Australia's two most common shellfish ecosystems, developed by Saccostrea glomerata and Ostrea angasi oysters, occurred during the mid-1800s to early 1900s in concurrence with extensive harvesting for food and lime production, ecosystem modification, disease outbreaks and a decline in water quality. Out of 118 historical locations containing O. angasi-developed ecosystems, only one location still contains the ecosystem whilst only six locations are known to still contain S. glomerata-developed ecosystems out of 60 historical locations. Ecosystems developed by the introduced oyster Crasostrea gigas are likely to be increasing in extent, whilst data on the remaining 11 ecosystem-forming species are limited, preventing a detailed assessment of their current ecosystem-forming status. Our analysis identifies that current knowledge on extent, physical characteristics, biodiversity and ecosystem services of Australian shellfish ecosystems is extremely limited. Despite the limited information on shellfish ecosystems, a number of restoration projects have recently been initiated across Australia and we propose a number of existing government policies and conservation mechanisms, if enacted, would readily serve to support the future conservation and recovery of Australia's shellfish ecosystems.

  2. Smart wearable systems: current status and future challenges.

    Science.gov (United States)

    Chan, Marie; Estève, Daniel; Fourniols, Jean-Yves; Escriba, Christophe; Campo, Eric

    2012-11-01

    Extensive efforts have been made in both academia and industry in the research and development of smart wearable systems (SWS) for health monitoring (HM). Primarily influenced by skyrocketing healthcare costs and supported by recent technological advances in micro- and nanotechnologies, miniaturisation of sensors, and smart fabrics, the continuous advances in SWS will progressively change the landscape of healthcare by allowing individual management and continuous monitoring of a patient's health status. Consisting of various components and devices, ranging from sensors and actuators to multimedia devices, these systems support complex healthcare applications and enable low-cost wearable, non-invasive alternatives for continuous 24-h monitoring of health, activity, mobility, and mental status, both indoors and outdoors. Our objective has been to examine the current research in wearable to serve as references for researchers and provide perspectives for future research. Herein, we review the current research and development of and the challenges facing SWS for HM, focusing on multi-parameter physiological sensor systems and activity and mobility measurement system designs that reliably measure mobility or vital signs and integrate real-time decision support processing for disease prevention, symptom detection, and diagnosis. For this literature review, we have chosen specific selection criteria to include papers in which wearable systems or devices are covered. We describe the state of the art in SWS and provide a survey of recent implementations of wearable health-care systems. We describe current issues, challenges, and prospects of SWS. We conclude by identifying the future challenges facing SWS for HM. Copyright © 2012 Elsevier B.V. All rights reserved.

  3. Australian shellfish ecosystems: Past distribution, current status and future direction

    Science.gov (United States)

    Gillies, Chris L.; McLeod, Ian M.; Alleway, Heidi K.; Cook, Peter; Crawford, Christine; Creighton, Colin; Diggles, Ben; Ford, John; Hamer, Paul; Heller-Wagner, Gideon; Lebrault, Emma; Le Port, Agnès; Russell, Kylie; Sheaves, Marcus; Warnock, Bryn

    2018-01-01

    We review the status of marine shellfish ecosystems formed primarily by bivalves in Australia, including: identifying ecosystem-forming species, assessing their historical and current extent, causes for decline and past and present management. Fourteen species of bivalves were identified as developing complex, three-dimensional reef or bed ecosystems in intertidal and subtidal areas across tropical, subtropical and temperate Australia. A dramatic decline in the extent and condition of Australia’s two most common shellfish ecosystems, developed by Saccostrea glomerata and Ostrea angasi oysters, occurred during the mid-1800s to early 1900s in concurrence with extensive harvesting for food and lime production, ecosystem modification, disease outbreaks and a decline in water quality. Out of 118 historical locations containing O. angasi-developed ecosystems, only one location still contains the ecosystem whilst only six locations are known to still contain S. glomerata-developed ecosystems out of 60 historical locations. Ecosystems developed by the introduced oyster Crasostrea gigas are likely to be increasing in extent, whilst data on the remaining 11 ecosystem-forming species are limited, preventing a detailed assessment of their current ecosystem-forming status. Our analysis identifies that current knowledge on extent, physical characteristics, biodiversity and ecosystem services of Australian shellfish ecosystems is extremely limited. Despite the limited information on shellfish ecosystems, a number of restoration projects have recently been initiated across Australia and we propose a number of existing government policies and conservation mechanisms, if enacted, would readily serve to support the future conservation and recovery of Australia’s shellfish ecosystems. PMID:29444143

  4. Membrane bioreactors in waste water treatment - status and trends

    Energy Technology Data Exchange (ETDEWEB)

    Kraume, M. [Technische Universitaet Berlin, Chair of Chemical and Process Engineering, Berlin (Germany); Drews, A. [HTW Berlin, FB II, Life Science Engineering, Berlin (Germany)

    2010-08-15

    Due to their unique advantages like controlled biomass retention, improved effluent quality, and decreased footprint, membrane bioreactors (MBRs) are being increasingly used in waste water treatment up to a capacity of several 100,000 p.e. This article reviews the current status of MBRs and reports trends in MBR design and operation. Typical operational and design parameters are given as well as guidelines for waste water treatment plant revamping. To further improve the biological performance, specific or hybrid process configurations are shown to lead to, e.g., enhanced nutrient removal. With regards to reducing membrane fouling, optimized modules, advanced control, and strategies like the addition of flux enhancers are currently emerging. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  5. Narcolepsy: current treatment options and future approaches

    Science.gov (United States)

    Billiard, Michel

    2008-01-01

    The management of narcolepsy is presently at a turning point. Three main avenues are considered in this review: 1) Two tendencies characterize the conventional treatment of narcolepsy. Modafinil has replaced methylphenidate and amphetamine as the first-line treatment of excessive daytime sleepiness (EDS) and sleep attacks, based on randomized, double blind, placebo-controlled clinical trials of modafinil, but on no direct comparison of modafinil versus traditional stimulants. For cataplexy, sleep paralysis, and hypnagogic hallucinations, new antidepressants tend to replace tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) in spite of a lack of randomized, double blind, placebo-controlled clinical trials of these compounds; 2) The conventional treatment of narcolepsy is now challenged by sodium oxybate, the sodium salt of gammahydroxybutyrate, based on a series of randomized, double-blind, placebo-controlled clinical trials and a long-term open label study. This treatment has a fairly good efficacy and is active on all symptoms of narcolepsy. Careful titration up to an adequate level is essential both to obtain positive results and avoid adverse effects; 3) A series of new treatments are currently being tested, either in animal models or in humans, They include novel stimulant and anticataplectic drugs, endocrine therapy, and, more attractively, totally new approaches based on the present state of knowledge of the pathophysiology of narcolepsy with cataplexy, hypocretine-based therapies, and immunotherapy. PMID:18830438

  6. [Development of antituberculous drugs: current status and future prospects].

    Science.gov (United States)

    Tomioka, Haruaki; Namba, Kenji

    2006-12-01

    authors reviewed (1) the history and present status of chemical genomics that is defined as the systemic search for a selective small molecular modulator for each function of all gene products, (2) recent studies of the authors on profiles of the interactions between various kinds of human proteins and small molecule modulators using the new technology devised by Reverse Proteomics Research Institute, and (3) future prospects of the development of new antituberculous drugs based on chemical genomics. 3. It appears also promising to develop new types of drug administration systems using drug vehicles, which enable efficacious drug delivery to their target in vivo. Dr. Izumikawa, Dr. Ohno and Dr. Kohno reviewed the usefulness of liposome- and polymer-based technologies, which enable efficacious delivery of encapsulated drugs at required doses for prolonged periods of time with only a single shot without toxicity, and also enable highly targeted delivery of drugs to their target in vivo. They indicated that the applications of drug delivery system using conventional anti-mycobacterial agents are challenging to improve the compliance of treatment and better clinical outcome. 4. Immunoadjunctive therapy appears to be promising in improving outcome of clinical control of refractory mycobacterial infections, including MDR-TB and M. avium complex infection. Dr. Shimizu, Dr. Sato and Dr. Tomioka reviewed the present status of immunotherapy of mycobacterial infections in combination with antimycobacterial drugs. They indicated that the development of new classes of immunomodulators other than cytokines (IL-2, IFN-gamma, GM-CSF, IL-12, etc.) particularly those with no severe side-effects, are urgently needed. Their review dealed with some promising immunoadjunctive agents, especially ATP and its analogues, which potentiate macrophage antimycobacterial activity via purinergic P2 receptors. The aim of this symposium is to address the future prospects of the development of new drugs

  7. Chemoradiotherapy for esophageal cancer. Current status and perspectives

    International Nuclear Information System (INIS)

    Ohtsu, Atsushi

    2004-01-01

    The optimal role of chemoradiotherapy in the multimodality treatment of esophageal cancer is still controversial. According to a series of clinical trials, definitive chemoradiotherapy is considered the standard of care for patients with medically inoperable or surgically unresectable esophageal cancer. This modality provides survivals comparable to those in Western series of surgery alone and is one of the standards of care even for resectable-stage disease. Recent reports of primary chemoradiotherapy from Japan suggest survival comparable to that of surgery in Japanese patients with stage I disease, but radical surgery is still the standard treatment for T2-3NanyM0 disease in Japan. However, it is clear that this approach has limitations in treatment outcomes. Trimodality therapy, i.e., preoperative chemoradiotherapy followed by surgery, is more favored than surgery alone in clinical practice, particularly in patients with adenocarcinoma, although current data from randomized trials are insufficient to support this approach. To improve the local control rate of chemoradiotherapy, intensification of the radiation dose has been attempted, but this has failed to demonstrate any superiority in terms of local control or survival. The addition of new agents, including molecular targeting agents, to the current standard chemoradiotherapy has shown more promising results and warrants further investigations in future studies. Salvage treatment for patients who do not achieve a complete response (CR) is necessary to improve the overall treatment results. Salvage surgery, as well as endoscopic resection, in selected patients, may provide an improvement in survival. Until high rates of local control can be consistently achieved with chemoradiotherapy alone, these salvage treatments will be an integral component of multimodality treatment for esophageal cancer, and should be active areas for clinical investigations. (author)

  8. Narcolepsy: current treatment options and future approaches

    Directory of Open Access Journals (Sweden)

    Michel Billiard

    2008-06-01

    Full Text Available Michel BilliardDepartment of Neurology, Gui de Chauliac Hospital, Montpellier, FranceAbstract: The management of narcolepsy is presently at a turning point. Three main avenues are considered in this review: 1 Two tendencies characterize the conventional treatment of narcolepsy. Modafinil has replaced methylphenidate and amphetamine as the first-line treatment of excessive daytime sleepiness (EDS and sleep attacks, based on randomized, double blind, placebo-controlled clinical trials of modafinil, but on no direct comparison of modafinil versus traditional stimulants. For cataplexy, sleep paralysis, and hypnagogic hallucinations, new antidepressants tend to replace tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs in spite of a lack of randomized, double blind, placebo-controlled clinical trials of these compounds; 2 The conventional treatment of narcolepsy is now challenged by sodium oxybate, the sodium salt of gammahydroxybutyrate, based on a series of randomized, double-blind, placebo-controlled clinical trials and a long-term open label study. This treatment has a fairly good efficacy and is active on all symptoms of narcolepsy. Careful titration up to an adequate level is essential both to obtain positive results and avoid adverse effects; 3 A series of new treatments are currently being tested, either in animal models or in humans, They include novel stimulant and anticataplectic drugs, endocrine therapy, and, more attractively, totally new approaches based on the present state of knowledge of the pathophysiology of narcolepsy with cataplexy, hypocretine-based therapies, and immunotherapy.Keywords: narcolepsy, treatment, conventional drugs, modafinil, sodium oxybate, future treatments

  9. Nuclear power for sustainable development. Current status and future prospects

    International Nuclear Information System (INIS)

    Adamantiades, A.; Kessides, I.

    2009-01-01

    Interest in nuclear power has been revived as a result of volatile fossil fuel prices, concerns about the security of energy supplies, and global climate change. This paper describes the current status and future plans for expansion of nuclear power, the advances in nuclear reactor technology, and their impacts on the associated risks and performance of nuclear power. Advanced nuclear reactors have been designed to be simpler and safer, and to have lower costs than currently operating reactors. By addressing many of the public health and safety risks that plagued the industry since the accidents at Three Mile Island and Chernobyl, these reactors may help break the current deadlock over nuclear power. In that case, nuclear power could make a significant contribution towards reducing greenhouse gas emissions. However, significant issues persist, fueling reservations among the public and many decision makers. Nuclear safety, disposal of radioactive wastes, and proliferation of nuclear explosives need to be addressed in an effective and credible way if the necessary public support is to be obtained. (author)

  10. [Current status and sustainable development countermeasures of Anoectochilus roxburghii].

    Science.gov (United States)

    Hong, Lin; Shao, Qing-Song; Zhou, Ai-Cun; Wang, Hong-Zhen; Zhang, Ai-Lian; Xu, Jian-Wei; Huang, Yu-Qiu

    2016-02-01

    The current status of the domestic manufacturing and sales markets of Anoectochilus roxburghii were investigated and analyzed in the study. Some problems in the A. roxburghii industry were revealed and a variety of sustainable development countermeasures were also proposed. The main problems of A. roxburghii industry are the lack of protection for wild resources, the lag in the speed of variety breeding, the insufficient research on the quality systems, the low level of industry and product innovation capability, as well as the relatively low market cognition and brand competence. Therefore, strengthening the protection for breeding resources, establishing a dynamic monitoring system, promoting the variety breeding, constructing a propagation system for improved varieties, enhancing the quality of medicinal herbs, accelerating the adjustment of product structure, upgrading the industry technology, strengthening brand competence and expanding the market, will be the effective methods to realize the sustainable development of A. roxburghii industry. Copyright© by the Chinese Pharmaceutical Association.

  11. Current Status of HbA1c Biosensors

    Science.gov (United States)

    Lin, Hua; Yi, Jun

    2017-01-01

    Glycated hemoglobin (HbA1c) is formed via non-enzymatic glycosylation reactions at the α–amino group of βVal1 residues in the tetrameric Hb, and it can reflect the ambient glycemic level over the past two to three months. A variety of HbA1c detection methods, including chromatography, immunoassay, enzymatic measurement, electrochemical sensor and capillary electrophoresis have been developed and used in research laboratories and in clinics as well. In this review, we summarize the current status of HbA1c biosensors based on the recognition of the sugar moiety on the protein and also their applications in the whole blood sample measurements. PMID:28777351

  12. Cobalt 60 gamma irradiation current status, trends and insights

    International Nuclear Information System (INIS)

    Corley, John T.

    1998-01-01

    This paper discusses the current status, trends and insights into the continued, safe use of cobalt 60 gamma irradiation. Also presented are some of the many initiatives undertaken at MDS Nordion. Topics covered include our investment for the future supply of raw materials and the latest news from source production. Briefly presented are the tasks associated with the safe transport of cobalt 60 around the world. Discussed is cobalt 60 usage at the customer site; more specifically maintaining source integrity, source utilization and irradiator design trends. Highlighted are industry trends for North America, Europe and the rest of the world. Finally presented are the challenges and opportunities for the industry. Stressed in the paper is the need to work together

  13. Current status of thermoluminescence studies on minerals and rocks

    International Nuclear Information System (INIS)

    Sankaran, A.V.; Nambi, K.S.V.; Sunta, C.M.

    1982-01-01

    The usefulness of thermoluminescence (TL) in geological studies is being increasingly recognized, as may be judged from the considerable volume of literature accumulated over the past couple of decades; besides, a number of seminars, conferences and specialists' meetings have also been held on the subject of applied TL. However, these publications lie scattered over several periodicals and conference proceedings and an interested worker finds it difficult to obtain the gist of the contributions in one place. The present authors felt a need for this and have, therefore, attempted to bring together in this Report the current status of TL research about different minerals; applications in the fields of geochronology, ore-prospecting, stratigraphic correlation, geothermometry and other useful areas are also included. (author)

  14. The current status of the Korean student health examination

    Directory of Open Access Journals (Sweden)

    Hye-Jung Shin

    2013-08-01

    Full Text Available Recent trends place an emphasis on school health care, the ultimate goal of which is to protect,maintain, and promote students’ health. School health care is a program that integrates health careservices, health education, health counseling, and local social health services. The student healthexamination (SHE system is a part of school health care and schools and communities must beavailable to provide professional health services. Pediatricians also have important roles as experts inboth school health care and the SHE system. In this article, the history of school health care, its legalbasis, and the current status of the SHE system in Korea are reviewed. Furthermore, sample surveysfrom the past few years are reviewed. Through this holistic approach, future directions are proposed forthe improvement of SHE and school health care.

  15. Current Status and Application of Hazard Definition Technology

    Science.gov (United States)

    Greene, George C.

    1997-01-01

    A research is performed: to define wake non-encounter & hazard, to provide requirements for sensors, and to obtain input from the user community. This research includes: validating wake encounter simulation models, establishing a metric to quantify the upset potential of a wake encounter, applying hazard metric and simulation models to the commercial fleet for development of candidate acceptable encounter limits, and applying technology to near term problems to evaluate current status of technology. The following lessons are learned from this project: technology is not adequate to determine absolute spacing requirements; time, not distance, determines the duration of the wake hazard; Optimum standards depend on the traffic; Wing span is an important parameter for characterizing both generator and follower; and Short span "biz jets" are easily rolled.

  16. Current Status of QA For Nuclear Power Plants in Japan

    International Nuclear Information System (INIS)

    Nagoshi, Hitohiko

    1986-01-01

    It is the current status of QA and our QA experiences with nuclear power plants against the background of the Japanese social and business environment. Accordingly, in 1972, 'The Guidance for Quality Assurance in Construction of Nuclear Power Plants' based on U. S. 10CEF50 Appendix B, was published by the Japan Electric Association. 'Jug-4101 The Guide for Quality Assurance of Nuclear Power Plants' has been prepared by referring to the IAEA QA code. The Guide has been accepted by the Japanese nuclear industry and applied to the QA programs of every organization concerned therewith. The Japanese approach to higher quality will naturally be different from that of other countries because of Japan's cultural, social, and economic conditions. Even higher quality is being aimed at through the LWR Improvement and Standardization Program and coordinated quality assurance efforts

  17. Advanced Gas Tungsten Arc Weld Surfacing Current Status and Application

    Directory of Open Access Journals (Sweden)

    Stephan Egerland

    2015-09-01

    Full Text Available Abstract Gas Shielded Tungsten Arc Welding (GTAW – a process well-known providing highest quality weld results joined though by lower performance. Gas Metal Arc Welding (GMAW is frequently chosen to increase productivity along with broadly accepted quality. Those industry segments, especially required to produce high quality corrosion resistant weld surfacing e.g. applying nickel base filler materials, are regularly in consistent demand to comply with "zero defect" criteria. In this conjunction weld performance limitations are overcome employing advanced 'hot-wire' GTAW systems. This paper, from a Welding Automation perspective, describes the technology of such devices and deals with the current status is this field – namely the application of dual-cathode hot-wire electrode GTAW cladding; considerably broadening achievable limits.

  18. The Dortmund low background facility. Current status and recent developments

    Energy Technology Data Exchange (ETDEWEB)

    Goessling, Claus; Kroeninger, Kevin; Nitsch, Christian [Experimentelle Physik IV, TU Dortmund, 44221 Dortmund (Germany)

    2016-07-01

    The Dortmund Low Background Facility (DLB) is a low-background gamma ray spectrometry system with an artificial overburden. The overburden of ten meters of water equivalent, in combination with a multi-layer lead castle and an active muon veto are shielding a high-purity germanium detector of 60 % relative efficiency. The background level is remarkably low compared to a conventional spectrometer system without special shielding and enables sensitivities well below 1 Bq/kg. Thus, material screening measurements as well as environmental monitoring measurements are possible on an easy-accessible location above ground at the campus of the Technische Universitaet Dortmund. The integral background count rate between 40 keV and 2700 keV is 2.528±0.004 counts/kg/min, which is comparable to systems that are situated below ground. In the talk, an overview of the current status of the DLB is given and recent developments are presented.

  19. Microbiological risk factors in dentistry. Current status of knowledge.

    Science.gov (United States)

    Szymańska, Jolanta

    2005-01-01

    Dentists belong to a professional group potentially exposed to harmful biological factors which most often are infectious microorganisms, less frequently - allergenic or toxic microorganisms. The fundamental routes of spreading harmful microorganisms in a dental surgery are: blood-borne, saliva-droplet, direct contact with a patient and with infected equipment, and water-droplet infections. In this paper, the current status of knowledge on microbiological hazards in a dentist's work is presented. Groups of microorganisms, such as prions, viruses, bacteria, fungi and protozoa, to which a dentist is, or may be exposed, are discussed. Epidemiological assessment of microbiological hazards in a dentist's work was performed and the basic principles of prevention formulated. Special attention was given to microflora in dental unit waterlines, and the biofilm persisting in them, as a source of occupational hazards specific for a dentist's workplace.

  20. Marine renewable energy in China: Current status and perspectives

    Directory of Open Access Journals (Sweden)

    Yong-liang Zhang

    2014-07-01

    Full Text Available Based on a general review of marine renewable energy in China, an assessment of the development status and amount of various marine renewable energy resources, including tidal energy, tidal current energy, wave energy, ocean thermal energy, and salinity gradient energy in China's coastal seas, such as the Bohai Sea, the Yellow Sea, the East China Sea, and the South China Sea, is presented. We have found that these kinds of marine renewable energy resources will play an important role in meeting China's future energy needs. Additionally, considering the uneven distribution of China's marine renewable energy and the influences of its exploitation on the environment, we have suggested several sites with great potential for each kind of marine energy. Furthermore, perspectives on and challenges related with marine renewable energy in China are addressed.

  1. Materials technology for fusion - Current status and future requirements

    International Nuclear Information System (INIS)

    Gold, R.E.; Bloom, E.E.; Clinard, F.W. Jr.; Smith, D.L.; Stevenson, R.D.; Wolfer, W.G.

    1981-01-01

    The general status of the materials research and development activities currently under way in support of controlled thermonuclear fusion reactors in the United States is reviewed. In the area of magnetic confinement configurations, attention is given to development programs for first wall materials, which are at various stages for possible austenitic stainless steels, high-strength Fe-Ni-Cr alloys, reactive and refractory metal alloys, specially designed long-range ordered and rapidly solidified alloys, and ferritic/martensitic steels, and for tritium breeding materials, electrical insulators, ceramics, and coolants. The development of materials for inertial confinement reactors is also surveyed in relation to the protection scheme employed for the first wall and the effects of pulsed neutron irradiation. Finally, the materials requirements and selection procedures for the ETF/INTOR and Starfire tokamak reactor designs are examined. Needs for the expansion of research on nonfirst-wall materials and inertial confinement fusion reactor material requirements are pointed out

  2. Current status of high energy nucleon-meson transport code

    Energy Technology Data Exchange (ETDEWEB)

    Takada, Hiroshi; Sasa, Toshinobu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-03-01

    Current status of design code of accelerator (NMTC/JAERI code), outline of physical model and evaluation of accuracy of code were reported. To evaluate the nuclear performance of accelerator and strong spallation neutron origin, the nuclear reaction between high energy proton and target nuclide and behaviors of various produced particles are necessary. The nuclear design of spallation neutron system used a calculation code system connected the high energy nucleon{center_dot}meson transport code and the neutron{center_dot}photon transport code. NMTC/JAERI is described by the particle evaporation process under consideration of competition reaction of intranuclear cascade and fission process. Particle transport calculation was carried out for proton, neutron, {pi}- and {mu}-meson. To verify and improve accuracy of high energy nucleon-meson transport code, data of spallation and spallation neutron fragment by the integral experiment were collected. (S.Y.)

  3. Current status of the Fastbus Micro-Vax

    International Nuclear Information System (INIS)

    Siskind, E.J.

    1985-01-01

    The present hardware, firmware, and software design and status of the Fastbus Micro-VAX, a two board Fastbus module packaging of the DEC Micro-VAX II computing system, is described. The hardware currently features an Intel 80186, equipped with 64 kB of ROM, 32 kB of RAM, and an 82586/82501 Ethernet port, as a front end I/O processor, plus a high bandwidth Fastbus interface implemented in semi-custom ECL 100K VLSI with the Motorola MCA2500ECL macrocell array. Standard 80186 firmware implements multiple Fastbus segment drivers and interrupt receivers software compatible with the UPI, a limited Fastbus interprocessor network, and emulations of the DEC DEQNA Ethernet interface and an MSCP disk interface. Software includes device drivers for the non-DEC devices, plus appropriate standard access subroutines for the Fastbus and network devices

  4. Current Status and Perspectives of Hyperthermia in Cancer Therapy

    Science.gov (United States)

    Hiraoka, Masahiro; Nagata, Yasushi; Mitsumori, Michihide; Sakamoto, Masashi; Masunaga, Shin-ichiro

    2004-08-01

    Clinical trials of hyperthermia in combination with radiation therapy or chemotherapy undertaken over the past decades in Japan have been reviewed. Originally developed heating devices were mostly used for these trials, which include RF (radiofrequency) capacitive heating devices, a microwave heating device with a lens applicator, an RF intracavitary heating device, an RF current interstitial heating device, and ferromagnetic implant heating device. Non-randomized trials for various cancers, demonstrated higher response rate in thermoradiotherapy than in radiotherapy alone. Randomized trials undertaken for esophageal cancers also demonstrated improved local response with the combined use of hyperthermia. Furthermore, the complications associated with treatment were not generally serious. These clinical results indicate the benefit of combined treatment of hyperthermia and radiotherapy for various malignancies. On the other hand, the presently available heating devices are not satisfactory from the clinical viewpoints. With the advancement of heating and thermometry technologies, hyperthermia will be more widely and safely used in the treatment of cancers.

  5. Recent advancements in bioremediation of dye: Current status and challenges.

    Science.gov (United States)

    Vikrant, Kumar; Giri, Balendu Shekhar; Raza, Nadeem; Roy, Kangkan; Kim, Ki-Hyun; Rai, Birendra Nath; Singh, Ram Sharan

    2018-04-01

    The rampant industrialization and unchecked growth of modern textile production facilities coupled with the lack of proper treatment facilities have proliferated the discharge of effluents enriched with toxic, baleful, and carcinogenic pollutants including dyes, heavy metals, volatile organic compounds, odorants, and other hazardous materials. Therefore, the development of cost-effective and efficient control measures against such pollution is imperative to safeguard ecosystems and natural resources. In this regard, recent advances in biotechnology and microbiology have propelled bioremediation as a prospective alternative to traditional treatment methods. This review was organized to address bioremediation as a practical option for the treatment of dyes by evaluating its performance and typical attributes. It further highlights the current hurdles and future prospects for the abatement of dyes via biotechnology-based remediation techniques. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Current Status of Nephron-Sparing Surgery (NSS) in the Management of Renal Tumours.

    Science.gov (United States)

    Venkatramani, Vivek; Swain, Sanjaya; Satyanarayana, Ramgopal; Parekh, Dipen J

    2017-06-01

    Nephron-sparing surgery has emerged as the surgical treatment of choice for small renal masses over the past two decades, replacing the traditional teaching of radical nephrectomy for renal cell carcinoma. With time, there has been an evolution in the techniques and indications for partial nephrectomy. This review summarizes the current status of nephron-sparing surgery for renal carcinoma and also deals with the future of this procedure.

  7. The current status of orphan drug development in Europe and the US

    OpenAIRE

    Hall, Anthony K; Carlson, Marilyn R

    2014-01-01

    Orphan drug legislation has been introduced in a number of countries in order to stimulate the development of treatments for rare diseases by introducing commercial incentives for companies wishing to undertake that development. In order to navigate the maze of regulatory regulations and procedures so that companies can make proper use of the orphan drug incentives, specialist knowledge is required. This article will review the current status of orphan drug development in the EU and the US, e...

  8. Exercise after breast cancer treatment: current perspectives

    Directory of Open Access Journals (Sweden)

    Dieli-Conwright CM

    2015-10-01

    Full Text Available Christina M Dieli-Conwright, Breanna Z Orozco Division of Biokinesiology and Physical Therapy, Women's Health and Exercise Laboratory, University of Southern California, Los Angeles, CA, USA Abstract: Over the past 2 decades, great strides have been made in the field of exercise-oncology research, particularly with breast cancer. This area of research is particularly important since there are >2.8 million breast cancer survivors who are in need of an intervention that can offset treatment-related side effects. Noticeable reductions in physical fitness (ie, cardiopulmonary fitness and muscular strength, negative changes in body composition (ie, increase in body mass, decrease in lean body mass, and increase in fat mass, increased fatigue, depression, or anxiety are some of the common side effects of cancer treatments that negatively impact overall quality of life and increase the risk for the development of comorbidities. Exercise plays a vital role in improving cardiopulmonary function, psychological events, muscular strength, and endurance in breast cancer survivors, and thus should be considered as a key factor of lifestyle intervention to reverse negative treatment-related side effects. The purpose of this review is to address current perspectives on the benefits of aerobic and resistance exercise after breast cancer treatments. This review is focused on the well-established benefits of exercise on physical and emotional well-being, bone health, lymphedema management, and the postulated benefits of exercise on risk reduction for recurrence of breast cancer. Keywords: breast cancer, exercise, physical well-being

  9. Marine current energy devices: Current status and possible future applications in Ireland

    International Nuclear Information System (INIS)

    Rourke, Fergal O.; Boyle, Fergal; Reynolds, Anthony

    2010-01-01

    There is a growing demand for the use of renewable energy technologies to generate electricity due to concerns over climate change. The oceans provide a huge potential resource of energy. Energy extraction using marine current energy devices (MCEDs) offers a sustainable alternative to conventional sources and a predictable alternative to other renewable energy technologies. A MCED utilises the kinetic energy of the tides as opposed to the potential energy which is utilised by a tidal barrage. Over the past decade MCEDs have become an increasingly popular method of energy extraction. However, marine current energy technology is still not economically viable on a large scale due to its current stage of development. Ireland has an excellent marine current energy resource as it is an island nation and experiences excellent marine current flows. This paper reviews marine current energy devices, including a detailed up-to-date description of the current status of development. Issues such as network integration, economics, and environmental implications are addressed as well as the application and costs of MCEDs in Ireland. (author)

  10. Current and future treatment options in osteoporosis.

    LENUS (Irish Health Repository)

    Brewer, Linda

    2012-02-01

    PURPOSE: The incidence of osteoporosis-related fractures will increase substantially over the coming decades as the population ages globally. This has important economic and public health implications, contributing substantially to morbidity and excess mortality in this population. METHODS: When prescribing for older patients the effectiveness profile of drugs needs to be balanced against their tolerability in individual patients. RESULTS: Currently we have good anti-fracture data to support the use of many available anti-resorptive and anabolic drugs including bisphosphonates, strontium ranelate and recombinant human parathyroid hormone. We also have evidence to demonstrate the importance of calcium and vitamin D repletion in these patients. However, in recent years our understanding of normal bone physiology and the mechanisms underlying the development of osteoporosis has significantly advanced and this has led to the development of new therapies. Novel agents, particularly denosumab, but also inhibitors of cathepsin K and anabolic agents that act on Wnt signalling, will increase the therapeutic options for clinicians in the coming years. CONCLUSION: This review discusses the evidence supporting the use of currently available treatment options for osteoporosis and potential future advances in drug therapy. Particular consideration should be given when prescribing for certain older patients who have issues with compliance or tolerance and also in those with co-morbidities or levels of frailty that may restrict the choice of therapy. Understanding the evidence for the benefit and possible harm of osteoporosis treatments is critical to appropriate management of this patient population.

  11. Current status of RTO development and its implications for Canada

    Energy Technology Data Exchange (ETDEWEB)

    MacDougall, M. [Powerex Corp., Vancouver, BC (Canada)

    2002-07-01

    This presentation includes a corporate review of Powerex, a review of Order 2000, and the current status of the Federal Energy Regulatory Commission's (FERC) efforts regarding Regional Transmission Operators (RTOs). Other topics of discussion include FERC's standard market design, an update of RTO West and implications for Canada. Powerex was incorporated in 1988 as a wholly-owned subsidiary of BC Hydro. British Columbia-based Powerex's heaviest trading is along the western-most states and Alberta, but it is slowly expanding into central and eastern markets. It evolved by selling and buying power at the United States Border. It received US FERC power marketing authorization in 1997 and has since seen sales jump from C$165 million to C$5.4 billion. Currently, the majority of power supply is from utilities other than BC Hydro. The presentation addresses issues such as the Federal Power Act, PUHCA and PURPA, and the 1992 Energy Policy Act which deals with expanded access to the power grid. Power Pool restructuring and FERC orders 888/889 are also discussed. 2 figs.

  12. Plutonium metal exchange program : current status and statistical analysis

    Energy Technology Data Exchange (ETDEWEB)

    Tandon, L. (Lav); Eglin, J. L. (Judith Lynn); Michalak, S. E. (Sarah E.); Picard, R. R.; Temer, D. J. (Donald J.)

    2004-01-01

    The Rocky Flats Plutonium (Pu) Metal Sample Exchange program was conducted to insure the quality and intercomparability of measurements such as Pu assay, Pu isotopics, and impurity analyses. The Rocky Flats program was discontinued in 1989 after more than 30 years. In 2001, Los Alamos National Laboratory (LANL) reestablished the Pu Metal Exchange program. In addition to the Atomic Weapons Establishment (AWE) at Aldermaston, six Department of Energy (DOE) facilities Argonne East, Argonne West, Livermore, Los Alamos, New Brunswick Laboratory, and Savannah River are currently participating in the program. Plutonium metal samples are prepared and distributed to the sites for destructive measurements to determine elemental concentration, isotopic abundance, and both metallic and nonmetallic impurity levels. The program provides independent verification of analytical measurement capabilies for each participating facility and allows problems in analytical methods to be identified. The current status of the program will be discussed with emphasis on the unique statistical analysis and modeling of the data developed for the program. The discussion includes the definition of the consensus values for each analyte (in the presence and absence of anomalous values and/or censored values), and interesting features of the data and the results.

  13. Current status of RTO development and its implications for Canada

    International Nuclear Information System (INIS)

    MacDougall, M.

    2002-01-01

    This presentation includes a corporate review of Powerex, a review of Order 2000, and the current status of the Federal Energy Regulatory Commission's (FERC) efforts regarding Regional Transmission Operators (RTOs). Other topics of discussion include FERC's standard market design, an update of RTO West and implications for Canada. Powerex was incorporated in 1988 as a wholly-owned subsidiary of BC Hydro. British Columbia-based Powerex's heaviest trading is along the western-most states and Alberta, but it is slowly expanding into central and eastern markets. It evolved by selling and buying power at the United States Border. It received US FERC power marketing authorization in 1997 and has since seen sales jump from C$165 million to C$5.4 billion. Currently, the majority of power supply is from utilities other than BC Hydro. The presentation addresses issues such as the Federal Power Act, PUHCA and PURPA, and the 1992 Energy Policy Act which deals with expanded access to the power grid. Power Pool restructuring and FERC orders 888/889 are also discussed. 2 figs

  14. Current Status of Postdoctoral and Graduate Programs in Dentistry.

    Science.gov (United States)

    Assael, Leon

    2017-08-01

    Advanced dental education has evolved in the context of societal needs and economic trends to its current status. Graduate programs have positioned their role in the context of health systems and health science education trends in hospitals, interprofessional clinical care teams, and dental schools and oral health care systems. Graduate dental education has been a critical factor in developing teams in trauma care, craniofacial disorders, pediatric and adult medicine, and oncology. The misalignment of the mission of graduate dental programs and the demands of private practice has posed a challenge in the evolution of programs as educational programs have been directed towards tertiary and indigent care while the practice community focuses on largely healthy affluent patients for complex clinical interventions. Those seeking graduate dental education today are smaller in number and include more international dental graduates than in the past. Graduate dental education in general dentistry and in the nine recognized dental specialties now includes Commission on Dental Accreditation (CODA) recognition of training standards as part of its accreditation process and a CODA accreditation process for areas of clinical education not recognized as specialties by the American Dental Association. Current types of programs include fellowship training for students in recognized specialties. This article was written as part of the project "Advancing Dental Education in the 21 st Century."

  15. Radio Astronomy in Malaysia: Current Status and Outreach Activities

    Science.gov (United States)

    Hashim, N.; Abidin, Z. Z.; Ibrahim, U. F. S. U.; Umar, R.; Hassan, M. S. R.; Rosli, Z.; Hamidi, Z. S.; Ibrahim, Z. A.

    2011-12-01

    In this paper, we will present the current status of radio astronomical research and outreach in Malaysia. We will also present a short history of our research group, which is currently the only radio astronomical facility in Malaysia. Our group is called the Radio Cosmology Research Lab and was established in 2005 by Dr Zamri Zainal Abidin and Prof Dr Zainol Abidin Ibrahim. We will discuss the future plans for this group including our keen interest in being part of a more global network of radio astronomers. We are already an active member of the South-East Asia Astronomy Network (SEAAN) and aims to have a radio astronomical facility in order to join the Global Very Long Baseline Interferometer (VLBI) as well becoming a research hub for the future Square Kilometer Array (SKA) project. We will also present some of the scientific goals of our group including providing a platform for radio astronomers to be able to do observations of weak and high red-shifted radio objects such as galaxy clusters and supernovae.

  16. Current treatment paradigms in rheumatoid arthritis.

    Science.gov (United States)

    Fries, J F

    2000-06-01

    Rheumatoid arthritis (RA) has traditionally been treated using the pyramid approach, in which non-steroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment and disease-modifying anti-rheumatic drugs (DMARDs) are introduced relatively late in the disease. This approach is no longer valid. Previously regarded as a benign disease, RA is now recognized as causing substantial morbidity and mortality, as do the NSAIDs used in treatment. DMARDs are more effective in controlling the pain and disability of RA than NSAIDs, and are often no more toxic. The current treatment paradigm emphasizes early, consistent use of DMARDs. A 'sawtooth' strategy of DMARD use has been proposed, in which a rising but low level of disability triggers a change in therapy. Determining the most clinically useful DMARD combinations and the optimal sequence of DMARD use requires effectiveness studies, Bayesian approaches and analyses of long-term outcomes. Such approaches will allow optimization of multiple drug therapies in RA, and should substantially improve the long-term outcome for many patients.

  17. Cost Estimating in DoD: Current Status, Trends, and What the Future Holds

    National Research Council Canada - National Science Library

    Nussbaum, Daniel A

    2005-01-01

    (1) Current Status: Baseline analysis of current cost estimating community, including which organizations are responsible for developing and reviewing cost estimates, how many personnel there are, what...

  18. Pediatric neurology training in Canada: current status and future directions.

    Science.gov (United States)

    Doja, Asif

    2012-05-01

    Child neurology training in Canada has changed considerably over time, with increasing requirements for standardized teaching of the fundamentals of child neurology and the CanMEDS competencies. We sought to determine the current status of child neurology training in Canada as well future directions for training. A web-based survey was sent to program directors (PD's) of active pediatric neurology training programs. General questions about the programs were asked, as well as about success at the Royal College of Physicians and Surgeons of Canada (RCPSC) exam, breakdown of rotations, views on CanMEDS roles and questions on the future of pediatric neurology. 9/9 PD's completed the survey. 96.5% of all trainees successfully passed their RCPSC exam from 2001-2006. Breakdowns of the number and type of rotations for each year of training were provided. All CanMEDS roles were deemed to be important by PD's and programs have developed unique strategies to teach and assess these roles.92.6% of trainees chose to go into academic practice, with the most popular subspecialty being epilepsy. All PD's favour joint training sessions particularly for neurogenetics and neuromuscular disease. Overall, PD's suggest recruitment for future child neurologists at the medical student level but are divided as to whether we are currently training too few or too many child neurologists. This survey provides a view of the current state of pediatric neurology training in Canada and suggestions for further development of post-graduate training. In particular, attention should be given to joint educational programs as well as urgently assessing the manpower needs of child neurologists.

  19. Personal dosimetric monitoring in Ukraine: current status and further development

    International Nuclear Information System (INIS)

    Chumak, V. V.; Musijachenkom, A. V.; Boguslavskaya, A. I.

    2003-01-01

    Presently Ukraine has mixed system for dosimetric monitoring. Nuclear power plants and some major nuclear facilities have their own dosimetry services, which are responsible for regular dosimetric monitoring of workers. Rest of occupationally exposed persons is monitored by dosimetry laboratories affiliated to the territorial authorities for sanitary and epidemiology supervision. In 2002-2003 Ukrainian Ministry of Health performed survey of the status of dosimetric monitoring and inventory of critical groups requiring such monitoring. Dosimetry services in Ukraine cover about 38,000 occupationally exposed workers, including 9,100 medical professionals, 16,400 employees of 5 nuclear power plants and ca.12,400 workers dealing with other sources of occupational exposure (industry, research). Territorial dosimetry services operate in 13 of 24 regions of Ukraine, using DTU-01 manual TLD readers produced with one exception in 1988-1990. The coverage of critical groups by dosimetric monitoring is variable and ranges from 38% to 100% depending on the region. Personnel of nuclear power plants (about 16,400 workers) is monitored by their own dosimetry services achieving absolute coverage of the main staff and temporary workers. Current inadequate status of dosimetric monitoring infrastructure in Ukraine demands an urgent elaboration of the united state system for monitoring and recording of individual doses. The proposed plan would allows to bring dosimetry infrastructure in Ukraine to the modern state which would be compatible with existing and future European and international radiation protection networks. Unitary structure of Ukraine, strong administrative command and good communications between regions of the country are positive factors in favour of efficient implementation of the proposed plan. Deficiencies are associated with limited funding of this effort. (authors)

  20. [Current status of neurostimulation and neuromodulation for vesicourethral dysfunction].

    Science.gov (United States)

    González-Chamorro, F; Verdú Tartajo, F; Hernández Fernández, C

    1997-01-01

    To describe the current indications, techniques and results of sacral root stimulation in patients with spinal cord lesions as a treatment for patients with high pressure bladders and/or urinary incontinence despite conservative management, as well as sacral root neuromodulation with permanent stimulators for complex bladder dysfunction: vesical instability, sensory urgency, chronic pelvic pain and chronic voiding dysfunction. The literature is reviewed, both techniques are described and the results of the most significant series are discussed, with special reference to the first groups that utilized these techniques. There is ample experience in the application of sacral root electrical stimulation. The reported results are comparable with those achieved by other treatments, such as augmentation cystoplasty. Neurostimulation and neuromodulation techniques are simple, the complications are minimal and they do not prelude the use of other therapies.

  1. [Current status and future perspectives of hepatocyte transplantation].

    Science.gov (United States)

    Pareja, Eugenia; Cortés, Miriam; Gómez-Lechón, M José; Maupoey, Javier; San Juan, Fernando; López, Rafael; Mir, Jose

    2014-02-01

    The imbalance between the number of potential beneficiaries and available organs, originates the search for new therapeutic alternatives, such as Hepatocyte transplantation (HT).Even though this is a treatment option for these patients, the lack of unanimity of criteria regarding indications and technique, different cryopreservation protocols, as well as the different methodology to assess the response to this therapy, highlights the need of a Consensus Conference to standardize criteria and consider future strategies to improve the technique and optimize the results.Our aim is to review and update the current state of hepatocyte transplantation, emphasizing the future research attempting to solve the problems and improve the results of this treatment. Copyright © 2013 AEC. Published by Elsevier Espana. All rights reserved.

  2. Current status of stem cells in cardiac repair.

    Science.gov (United States)

    Henning, Robert J

    2018-03-01

    One out of every two men and one out of every three women greater than the age of 40 will experience an acute myocardial infarction (AMI) at some time during their lifetime. As more patients survive their AMIs, the incidence of congestive heart failure (CHF) is increasing. 6 million people in the USA have ischemic cardiomyopathies and CHF. The search for new and innovative treatments for patients with AMI and CHF has led to investigations and use of human embryonic stem cells, cardiac stem/progenitor cells, bone marrow-derived mononuclear cells and mesenchymal stem cells for treatment of these heart conditions. This paper reviews current investigations with human embryonic, cardiac, bone marrow and mesenchymal stem cells, and also stem cell paracrine factors and exosomes.

  3. [Current status and clinical application prospect of Akabane's test].

    Science.gov (United States)

    Wang, Wenjie; Du, Yanjun

    2016-06-12

    The Akabane's test is one of the meridian diagnostic methods. Compared with the current meridian diagnostic methods, it has the advantages of convenience and efficiency, but it also has several disadvantages such as the accuracy is difficult to control, the outcome interpretation is limited, etc. In this paper, the influence factors of Akabane's test were analyzed one by one, especially proposed personal opinion on outcome interpretation, which could ascertain the location and nature of disease, leading to disease syndrome. With accurate syndrome, the treatment plan could be established. The application prospect of Akabane's test was initially explored, and it was proposed that wearable automation equipment could be one of the development directions.

  4. Current status and future prospects on nuclear industry in Korea

    International Nuclear Information System (INIS)

    Lee, Joongjae

    2006-01-01

    It is ny great pleasure to have this chance of speaking at twenty-first KAIF/KNS Annual Conference, with the subject of the current status and future prospects of nuclear industry in Korea. As you all know, since the start of operation in Obninsk, the former Soviet Union, on June 26th, 1954, nuclear generation in the world has expanded continuously for the past 50 years. In 1973, when the first oil crisis hit the world, there were 147 nuclear power plants in operation, supplying only 0.8% of the world energy demand. About 30 years later, by the end of last year, 443 plants were in operation in 32 countries, supplying about 16% of the world power demand. Nuclear power generation is greatly contributing to the energy security of many countries and preservation of global environments. Recently, countries all over the world are becoming aware of the values and importance of nuclear energy which can help respond to energy crises caused by a sharp rise in oil prices and protect the earth from global warming. Due to its high energy density and ability to secure fuel supply at a lower cost, in addition to its cleanliness resulting from almost no emission of greenhouse gases, nuclear power generation is the practical alternative for energy security and the prevention of global warming. However, in the rapidly changing 21st century, the nuclear industries of the world, as well as Korea, are facing more challenges than ever before. The political and social disputes on nuclear generation are continuing while we all are facing urgent challenges, including the concerns about the safety of nuclear generation, procuring site to build nuclear power plants, and the improvement of competitiveness. Please allow me to remind you that it is very important for the world's nuclear societies to cooperate together in order to overcome diverse difficulties along our path and to contribute to the development of mankind and preservation of natural environments with nuclear power as a

  5. [Current status and potential perspectives in classical radiotherapy technology].

    Science.gov (United States)

    Dabić-Stanković, Kata M; Stanković, Jovan B; Radosević-Jelić, Ljiljana M

    2004-01-01

    After purchase of radiotherapy equipment in 2003, classic radiation therapy in Serbia will reach the highest world level. In order to define the highest standards in radiation technology, we analyzed the current status and potential perspectives of radiation therapy. An analysis of present situation in the USA, assumed as the most developed in the world, was done. Available data, collected in the last 3 years (equipment assortment, therapy modalities, workload and manpower) for 284 radiotherapy centers, out of potential 2050, were analyzed. Results were presented as crude percentage and matched to point current status. The analysis showed that CLINAC accelerators are the most popular (82.7%), as well as, ADAC (43.7%) and Focus (CMS) (27.4%) systems for therapy planning. Movement towards virtual simulation is evident (59.3%), although classic "simulation" is not fully eliminated from the radiotherapy chain. The most popular brachytherapy afterloader is Microselectron HDR (71%). About 64.4% centers use IMPAC communication/verification/record system that seems more open than Varis. All centers practice modern radiotherapy modalities and techniques (CPRT, IMRT, SRS/SRT, TBI, IORT, IVBHRT, HDR BHRT, etc.). CT and MRI availability is out of question, but PET is available in 3% of centers, however this percentage is rapidly growing. Up to 350 new patients per year are treated by one accelerator (about 35 pts. a day). Centers are relatively small and utilize 2-3 accelerators on average. Average FTE staffing norm is 4 radiation oncologists, 2-3 medical radiotherapy physicists, about 3 certified medical dosimetrists and about 6 radiotherapy technologists. In the past 5 years relative stagnation in classic radiotherapy has been observed. In spite of substantial investments in technology and consequent improvements, as well as wide introduction of computers in radiotherapy, radiotherapy results have not changed significantly. Vendor developement strategies do not point that

  6. Current status, new frontiers and challenges in radiation biodosimetry using cytogenetic, transcriptomic and proteomic technologies

    Energy Technology Data Exchange (ETDEWEB)

    Fenech, Michael, E-mail: michael.fenech@csiro.au [Commonwealth Scientific and Industrial Research Organisation, Gate 13 Kintore Avenue, Adelaide, SA 5000 (Australia)

    2011-09-15

    Biodosimetric methods for determining exposure dose in individuals following a radiation accident are important for the health management of the exposed cohort and prioritisation of high dose exposure cases to receive emergency medical treatment. This brief review provides a succinct outline of (i) the current status of standard cytogenetic methods used in radiation biodosimetry; (ii) development of high-throughput systems for current standard cytogenetic methods; (iii) emerging minimally invasive methods; (iv) the impact of nutrition and genotype on observed dose-response relationships and (v) new frontiers in biodosimetry using molecular biology techniques such as transcriptomics and proteomics.

  7. Cognitive function in older adults according to current socioeconomic status.

    Science.gov (United States)

    Zhang, Michael; Gale, Shawn D; Erickson, Lance D; Brown, Bruce L; Woody, Parker; Hedges, Dawson W

    2015-01-01

    Cognitive function may be influenced by education, socioeconomic status, sex, and health status. Furthermore, aging interacts with these factors to influence cognition and dementia risk in late life. Factors that may increase or decrease successful cognitive aging are of critical importance, particularly if they are modifiable. The purpose of this study was to determine if economic status in late life is associated with cognition independent of socioeconomic status in early life. Cross-sectional demographic, socioeconomic, and cognitive function data were obtained in 2592 older adults (average age 71.6 years) from the Center for Disease Control's National Health and Nutrition Examination Survey (NHANES) and analyzed with linear regression modeling. Cognitive function, as measured with a test of processing speed, was significantly associated with poverty index scores after adjusting for educational attainment as an estimate of childhood socioeconomic status, ethnic background, age, health status, and sex (P status is independently associated with cognitive function in adults over age 60 years.

  8. Parastomal hernia - current knowledge and treatment.

    Science.gov (United States)

    Styliński, Roman; Alzubedi, Adam; Rudzki, Sławomir

    2018-03-01

    Intestinal stoma creation is one of the most common surgical procedures. The most common long-term complication following stoma creation is parastomal hernia, which according to some authors is practically unavoidable. Statistical differences of its occurrence are mainly due to patient observation time and evaluation criteria. Consequently, primary prevention methods such as placement of prosthetic mesh and newly developed minimally invasive methods of stoma creation are used. It seems that in the light of evidence-based medicine, the best way to treat parastomal hernia is the one that the surgeon undertaking therapy is the most experienced in and is suited to the individuality of each patient, his condition and comorbidities. As a general rule, reinforcing the abdominal wall with a prosthetic mesh is the treatment of choice, with a low rate of complications and relapses over a long period of time. The current trend is to use lightweight, large pore meshes.

  9. Ventilator-associated pneumonia: current status and future recommendations.

    Science.gov (United States)

    Efrati, Shai; Deutsch, Israel; Antonelli, Massimo; Hockey, Peter M; Rozenblum, Ronen; Gurman, Gabriel M

    2010-04-01

    Ventilator-associated pneumonia (VAP) is a common hazardous complication in ICU patients. The aim of the current review is to give an update on the current status and future recommendations for VAP prevention. This article gives an updated review of the current literature on VAP. The first part briefly reviews pathogenesis and epidemiology while the second includes an in-depth review of evidence-based practice guidelines (EBPG) and new technologies developed for prevention of VAP. VAP remains a frequent and costly complication of critical illness with a pooled relative risk of 9-27% and mortality of 25-50%. Strikingly, VAP adds an estimated cost of more than $40,000 to a typical hospital admission. An important aetiological mechanism of VAP is gross or micro-aspiration of oropharyngeal organisms around the cuff of the endotracheal tube (ETT) into the distal bronchi. Prevention of VAP is preferable. Preventative measures can be divided into two main groups: the implemen- tation of EBPGs and use of device-based technologies. EBPGs have been authored jointly by the American Thoracic Society and the Infectious Diseases Society of America. The Canadian Critical Care Trials group also published VAP Guidelines in 2008. Their recommendations are detailed in this review. The current device-based technologies include drainage of subglottic secretions, silver coated ETTs aiming to influence the internal bio-layer of the ETT, better sealing of the lower airways with ultrathin cuffs and loops for optimal cuff pressure control. EBPG consensus includes: elevation of the head of the bed, use of daily "sedation vacations" and decontamination of the oropharynx. Technological solutions should aim to use the most comprehensive combination of subglottic suction of secretions, optimization of ETT cuff pressure and ultrathin cuffs. VAP is a type of hospital-acquired pneumonia that develops more than 48 h after endotracheal intubation. Its incidence is estimated to be 9-27%, with a

  10. Chemoradiotherapy for lung cancer. Current status and perspectives

    International Nuclear Information System (INIS)

    Ohe, Yuichiro

    2004-01-01

    For many years, thoracic radiotherapy had been regarded as the standard treatment for patients with unresectable locally advanced non-small cell lung cancer. However, meta-analyses show that cisplatin-containing chemoradiotherapy is significantly superior to radiotherapy alone in terms of survival. Moreover, concurrent chemoradiotherapy yields a significantly increased response rate and enhanced survival duration when compared with the sequential approach. Cisplatin-based chemotherapy with concurrent thoracic radiotherapy yields a 5-year survival rate of approximately 15% for patients with unresectable locally advanced non-small cell lung cancer. The state-of-the-art treatment for limited-stage small cell lung cancer is considered to be four cycles of combination chemotherapy with cisplatin plus etoposide combined with early concurrent twice-daily thoracic irradiation (45 Gy). If patients achieve complete remission, prophylactic cranial irradiation should be administered. A 5-year survival rate of approximately 25% is expected with the state-of-the-art treatment for limited-stage small cell lung cancer. Chemoradiotherapy is considered to be a standard treatment for both unresectable locally advanced non-small cell lung cancer and limited-stage small cell lung cancer. Several new strategies are currently being investigated to improve the survival of these patients. The incorporation of target-based drugs such as gefitinib is considered to be the most promising strategy for unresectable locally advanced non-small cell lung cancer. The incorporation of irinotecan is also a promising strategy to improve the survival of patients with limited-stage small cell lung cancer. The Japan Clinical Oncology Group is conducting clinical trials to develop new treatment strategies for both unresectable locally advanced non-small cell lung cancer and limited-stage small cell lung cancer. (author)

  11. Cyclotron facilities in Brazil: Current status and licensing aspects

    International Nuclear Information System (INIS)

    Facure, A.; Carvalho, S.M.; Di Prinzio, R.; Silveira, C.S.; Gasparian, P.B.R.; Franca, W.F.

    2017-01-01

    Positron Emission Tomography (PET) is a highly sensitive and accurate nuclear medicine imaging technology but the major problem of this technique is the use of radioisotopes with short half-life, less than two hours. The production and selling of short half-life radioisotopes used to be monopoly of the Brazilian Government. In 2006, a Constitutional Amendment revoked the state monopoly due to the need for the use of short half-life radioisotopes in nuclear medicine centers very far from the government production facilities. The aim of this study is to describe the current status of short half-life radioisotopes production in Brazil and discuss some licensing process. In Brazil, as has been occurring worldwide, the number of nuclear medicine centers is increasing. Currently there are 123 services performing PET scans in Brazil. There are 14 cyclotrons operating in Brazil. The type of licensing process conducted in Brazil does not take into account the population density of each state, with a free competition model being adopted. Because of this there is a lot of equipment concentrated in the Southeast and no cyclotrons operating in the Northern part of the country. One of the biggest obstacles during the licensing process is the designation of qualified personnel as operation workers and radiation safety officers. The number of cyclotron accelerators and PET/CT equipment increased in recent years. However, a number of external factors such as the distance from the nuclear medicine centers, and qualified personnel have proved crucial for the economic viability of this type of facility. (author)

  12. Cyclotron facilities in Brazil: Current status and licensing aspects

    Energy Technology Data Exchange (ETDEWEB)

    Facure, A.; Carvalho, S.M.; Di Prinzio, R.; Silveira, C.S.; Gasparian, P.B.R.; Franca, W.F., E-mail: facure@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2017-09-01

    Positron Emission Tomography (PET) is a highly sensitive and accurate nuclear medicine imaging technology but the major problem of this technique is the use of radioisotopes with short half-life, less than two hours. The production and selling of short half-life radioisotopes used to be monopoly of the Brazilian Government. In 2006, a Constitutional Amendment revoked the state monopoly due to the need for the use of short half-life radioisotopes in nuclear medicine centers very far from the government production facilities. The aim of this study is to describe the current status of short half-life radioisotopes production in Brazil and discuss some licensing process. In Brazil, as has been occurring worldwide, the number of nuclear medicine centers is increasing. Currently there are 123 services performing PET scans in Brazil. There are 14 cyclotrons operating in Brazil. The type of licensing process conducted in Brazil does not take into account the population density of each state, with a free competition model being adopted. Because of this there is a lot of equipment concentrated in the Southeast and no cyclotrons operating in the Northern part of the country. One of the biggest obstacles during the licensing process is the designation of qualified personnel as operation workers and radiation safety officers. The number of cyclotron accelerators and PET/CT equipment increased in recent years. However, a number of external factors such as the distance from the nuclear medicine centers, and qualified personnel have proved crucial for the economic viability of this type of facility. (author)

  13. Current status of the UCSF second-generation PACS

    Science.gov (United States)

    Huang, H. K.; Arenson, Ronald L.; Wong, Albert W. K.; Bazzill, Todd M.; Lou, Shyhliang A.; Andriole, Katherine P.; Wang, Jun; Zhang, Jianguo; Wong, Stephen T. C.

    1996-05-01

    This paper describes the current status of the second generation PACS at UCSF commenced in October 1992. The UCSF PACS is designed in-house as a hospital-integrated PACS based on an open architecture concept using industrial standards including UNIX operating system, C programming language, X-Window user interface, TCP/IP communication protocol, DICOM 3.0 image standard and HL7 health data format. Other manufacturer's PACS components which conform with these standards can be easily integrated into the system. Relevant data from HIS and RIS is automatically incorporated into the PACS using HL7 data format and TCP/IP communication protocol. The UCSF system also takes advantage of state-of-the-art communication, storage, and software technologies in ATM, multiple storage media, automatic programming, multilevel processes for a better cost-performance system. The primary PACS network is the 155 Mbits/sec OC3 ATM with the Ethernet as the back-up. The UCSF PACS also connects Mt. Zion Hospital and San Francisco VA Medical Center in the San Francisco Bay area via an ATM wide area network with a T1 line as the back-up. Currently, five MR and five CT scanners from multiple sites, two computed radiography systems, two film digitizers, one US PACS module, the hospital HIS and the department RIS have been connected to the PACS network. The image data is managed by a mirrored database (Sybase). The PACS controller, with its 1.3 terabyte optical disk library, acquires 2.5 gigabytes digital data daily. Four 2K, five, 1,600-line multiple monitor display workstations are on line in neuroradiology, pediatric radiology and intensive care units for clinical use. In addition, the PACS supports over 100 Macintosh users in the department and selected hospital sites for both images and textual retrieval through a client/server mechanism. We are also developing a computation and visualization node in the PACS network for advancing radiology research.

  14. SaudiVeg ecoinformatics: Aims, current status and perspectives

    Directory of Open Access Journals (Sweden)

    Mohamed A. El-Sheikh

    2017-02-01

    Full Text Available During the last decade many electronic databases of vegetation plots were established in many countries around the world. These databases contain valuable phytosociological information assisting both governmental and NGO (Non-governmental organizations agencies to formulate strategies and on-ground plans to manage and protect nature resources. This paper provides an account on aims, current status and perspectives of building of a vegetation database for the Central Region (Najd of Saudi Arabia – the founding element of the Saudi Vegetation Database (SVD. The data stored by the database are sample plots (vegetation relevés collected according to the field techniques of the Braun-Blanquet approach (lists of taxa accompanied by semi-quantitative cover assessment, and are accompanied by general vegetation characteristics such as vegetation layering and cover, information on life-form of the recorded species, geographical coordinates, altitude, soil typology, topography and many more. More than 2900 vegetation-plot records (relevés have so far been collected in the Najd region; of these more than 2000 have already been stored using the Turboveg database platform. These field records cover many habitats such as depressions, wadis (dry river beds, agricultural lands, sand dunes, sabkhas, and ruderal habitats. The ecological information collected in the database is currently the largest set of vegetation data collated into a database in the Middle East. These data are of great importance for biodiversity studies in Saudi Arabia, since the region is recording a loss of biodiversity at a fast rate due to environmental problems such as global warming and land-use changes. We envisage that this database would catalyze further data collection on vegetation of the entire Arabian Peninsula, and shall serve as one of the most important datasets for classification and mapping of the vegetation of the Kingdom of Saudi Arabia.

  15. Oil development in China: Current status and future trends

    International Nuclear Information System (INIS)

    Ma Linwei; Fu Feng; Li Zheng; Liu Pei

    2012-01-01

    The future of oil has become an important topic of the discussion of energy policy in China. This paper attempts to present a full picture of the current status and future trends of China’s oil development through system analysis. First, we map a Sankey diagram of China’s oil flow to reveal the physical pattern of China’s oil supply and consumption. Then, we present the historical and ongoing trends of China’s oil flow from key aspects such as oil demand, oil resource availability, technology improvement, and policy adjustment. Based on these understandings, we design three scenarios of China’s oil demand in 2030, and analyze policy implications for oil saving, automotive energy development, and energy security. From the analysis, we draw some conclusions for policy decisions, such as to control the total oil consumption to avoid energy security risks, to enhance oil saving in all sectors with road transportation as the emphasis, and to increase the investment on oil production and refining to secure oil supply and reduce emissions. - Highlights: ► A Sankey Diagram to reveal the physical pattern of China’s oil supply and consumption. ► Present the ongoing trends of China’s oil development. ► Discuss important policy issues such as oil saving, energy security, and emissions reduction.

  16. The current status and prospect of nuclear power in China

    Energy Technology Data Exchange (ETDEWEB)

    Wei, S. [State Nuclear Power Technology Corp., Beijing (China)

    2014-07-01

    'Full text:' China's nuclear power development has attracted world attention. This paper presented the current status of the nuclear power plant in China. By June 30, 2014, China has 20 operational units of 18.05GWe installed capacity, taking up 1.44% of the country's total. All the units have been operating well without any events above INES Level 1 in 2013. China also has 28 units of 30.5GWe installed capacity under construction, which accounts for around 40% of that in the world. The paper presented the progress of AP1000 in China. China made a national plan for 2011 to 2020 with the target to reach 58GWe operational nuclear power and 30GWe under construction by 2020. The Chinese President Xi Jinping urged recently to speed up the approval for new builds. This paper also presented the work of 'Go Global' by Chinese nuclear companies, i.e., their development of international market. (author)

  17. The current status of radiological protection infraestructures in Tanzania

    International Nuclear Information System (INIS)

    Ngalie, J.E.; Mompome, W.K.; Meza, L.H.

    2008-01-01

    Without adequate and sustainable radiation protection infrastructure, the benefits associated with safe use of nuclear technology and atomic energy might be jeopardized. In the United Republic of Tanzania, the Atomic Energy Act No. 7 of 2003 established the Tanzania Atomic Energy Commission as sole regulatory body responsible for regulating and controlling the safe and peaceful utilization of nuclear technology in the country. The Atomic Energy (Protection from ionizing radiation) Regulations, 2004 further specifies practices designed to ensure that unnecessary exposure of persons to ionizing radiation is avoided, that all exposures are kept as low as reasonably achievable and that all the dose limits specified in the radiation protection standards are not exceeded. This is achieved through the systems of notification, authorizations through registration and licensing, safety and security of radiation sources as well as regulatory inspections and enforcements. These activities are performed by the Commission with operational funds allocated by the Government of Tanzania. The Commission further provides other services namely individual monitoring; calibration services; education and training to radiation workers, public as well as law enforcers; and safe management of radioactive waste. Despite such achievement, still there are a lot to be done in order to strengthen the radiation protection infrastructure in Tanzania. These include issues such as gaps in our legislations, regulations and guidance, security of sources, enforcement of laws, etc. This paper describes and discusses the current status of the regulatory control activities and radiation protection services provided by the Commission and suggestions for further improvement of radiological protection infrastructure in Tanzania. (author)

  18. Current Status of Mycotoxin Contamination of Food Commodities in Zimbabwe

    Directory of Open Access Journals (Sweden)

    Nancy Nleya

    2018-05-01

    Full Text Available Agricultural products, especially cereal grains, serve as staple foods in sub-Saharan Africa. However, climatic conditions in this region can lead to contamination of these commodities by moulds, with subsequent production of mycotoxins posing health risks to both humans and animals. There is limited documentation on the occurrence of mycotoxins in sub-Saharan African countries, leading to the exposure of their populations to a wide variety of mycotoxins through consumption of contaminated foods. This review aims at highlighting the current status of mycotoxin contamination of food products in Zimbabwe and recommended strategies of reducing this problem. Zimbabwe is one of the African countries with very little information with regards to mycotoxin contamination of its food commodities, both on the market and at household levels. Even though evidence of multitoxin occurrence in some food commodities such as maize and other staple foods exist, available published research focuses only on Aspergillus and Fusarium mycotoxins, namely aflatoxins, deoxynivalenol (DON, trichothecenes, fumonisins, and zearalenone (ZEA. Occurrence of mycotoxins in the food chain has been mainly associated with poor agricultural practices. Analysis of mycotoxins has been done mainly using chromatographic and immunological methods. Zimbabwe has adopted European standards, but the legislation is quite flexible, with testing for mycotoxin contamination in food commodities being done voluntarily or upon request. Therefore, the country needs to tighten its legislation as well as adopt stricter standards that will improve the food safety and security of the masses.

  19. Current Status of Mycotoxin Contamination of Food Commodities in Zimbabwe.

    Science.gov (United States)

    Nleya, Nancy; Adetunji, Modupeade Christianah; Mwanza, Mulunda

    2018-05-03

    Agricultural products, especially cereal grains, serve as staple foods in sub-Saharan Africa. However, climatic conditions in this region can lead to contamination of these commodities by moulds, with subsequent production of mycotoxins posing health risks to both humans and animals. There is limited documentation on the occurrence of mycotoxins in sub-Saharan African countries, leading to the exposure of their populations to a wide variety of mycotoxins through consumption of contaminated foods. This review aims at highlighting the current status of mycotoxin contamination of food products in Zimbabwe and recommended strategies of reducing this problem. Zimbabwe is one of the African countries with very little information with regards to mycotoxin contamination of its food commodities, both on the market and at household levels. Even though evidence of multitoxin occurrence in some food commodities such as maize and other staple foods exist, available published research focuses only on Aspergillus and Fusarium mycotoxins, namely aflatoxins, deoxynivalenol (DON), trichothecenes, fumonisins, and zearalenone (ZEA). Occurrence of mycotoxins in the food chain has been mainly associated with poor agricultural practices. Analysis of mycotoxins has been done mainly using chromatographic and immunological methods. Zimbabwe has adopted European standards, but the legislation is quite flexible, with testing for mycotoxin contamination in food commodities being done voluntarily or upon request. Therefore, the country needs to tighten its legislation as well as adopt stricter standards that will improve the food safety and security of the masses.

  20. Current status of the development of international exemption principles

    International Nuclear Information System (INIS)

    Kennedy, W.E. Jr.

    1988-01-01

    For the past several years, the International Atomic Energy Agency (IAEA) has been investigating the possibility of exempting certain radiation sources and practices from regulatory control. Initial efforts were conducted under the general heading of de minimis. Interest in this topic arises from international recognition that a significant fraction of the wastes from industry, research, medicine, and the nuclear fuel cycle are contaminated to such low levels that applying regulatory controls may be unwarranted. The IAEA evaluation has been conducted by Advisory Groups considering two interrelated topics: to establish principles for exemption, and to apply the principles to various areas of waste management. The IAEA Advisory Groups developed the criteria from modeled assessments of the potential radiation exposure pathways and scenarios for individuals and population groups following the unrestricted release of radioactive materials. Although the scenarios and models used by the IAEA are necessarily generic, consultants to the Advisory Groups attempted to identify the most important radiation exposure pathways based on available literature. This approach is intended to provide the basic framework for the numerical derivation of generic exempt quantities that would be conservative in most situations. This paper discusses the current status of the IAEA's efforts on the subject of exemption and presents the generic results expressed as overall exemption limits for municipal wastes and materials for recycle and reuse

  1. Plague in Iran: its history and current status

    Directory of Open Access Journals (Sweden)

    Abdolrazagh Hashemi Shahraki

    2016-07-01

    Full Text Available OBJECTIVES: Plague remains a public health concern worldwide, particularly in old foci. Multiple epidemics of this disease have been recorded throughout the history of Iran. Despite the long-standing history of human plague in Iran, it remains difficult to obtain an accurate overview of the history and current status of plague in Iran. METHODS: In this review, available data and reports on cases and outbreaks of human plague in the past and present in Iran and in neighboring countries were collected, and information was compiled regarding when, where, and how many cases occurred. RESULTS: This paper considers the history of plague in Persia (the predecessor of today’s Iran and has a brief review of plague in countries in the World Health Organization Eastern Mediterranean Region, including a range of countries in the Middle East and North Africa. CONCLUSIONS: Since Iran has experienced outbreaks of plague for several centuries, neighboring countries have reported the disease in recent years, the disease can be silent for decades, and the circulation of Yersinia pestis has been reported among rodents and dogs in western Iran, more attention should be paid to disease monitoring in areas with previously reported human cases and in high-risk regions with previous epizootic and enzootic activity.

  2. Plague in Iran: its history and current status.

    Science.gov (United States)

    Hashemi Shahraki, Abdolrazagh; Carniel, Elizabeth; Mostafavi, Ehsan

    2016-01-01

    Plague remains a public health concern worldwide, particularly in old foci. Multiple epidemics of this disease have been recorded throughout the history of Iran. Despite the long-standing history of human plague in Iran, it remains difficult to obtain an accurate overview of the history and current status of plague in Iran. In this review, available data and reports on cases and outbreaks of human plague in the past and present in Iran and in neighboring countries were collected, and information was compiled regarding when, where, and how many cases occurred. This paper considers the history of plague in Persia (the predecessor of today's Iran) and has a brief review of plague in countries in the World Health Organization Eastern Mediterranean Region, including a range of countries in the Middle East and North Africa. Since Iran has experienced outbreaks of plague for several centuries, neighboring countries have reported the disease in recent years, the disease can be silent for decades, and the circulation of Yersinia pestis has been reported among rodents and dogs in western Iran, more attention should be paid to disease monitoring in areas with previously reported human cases and in high-risk regions with previous epizootic and enzootic activity.

  3. Current Status of Carl Sagan Observatory in Mexico

    Science.gov (United States)

    Sanchez-Ibarra, A.

    The current status of Observatory "Carl Sagan" (OCS) of University of Sonora is presented. This project was born in 1996 focused to build a small solar-stellar observatory completely operated by remote control. The observatory will be at "Cerro Azul", a 2480 m peak in one of the best regions in the world for astronomical observation, at the Sonora-Arizona desert. The OCS, with three 16 cm solar telescopes and a 55 cm stellar telescope is one of the cheapest observatories, valuated in US200,000 Added to its scientific goals to study solar coronal holes and Supernovae Type 1A, the OCS has a strong educative and cultural program in Astronomy to all levels. At the end of 2001, we started the Program "Constelacion", to build small planetariums through all the countries with a cost of only US80,000. Also, the webcast system for transmission of the solar observations from the prototype OCS at the campus, was expanded to webcast educational programs in Astronomy since July of this year, including courses and diplomats for Latin American people. All of these advances are exposed here.

  4. Preimplantation genetic diagnosis and screening: Current status and future challenges

    Directory of Open Access Journals (Sweden)

    Hsin-Fu Chen

    2018-02-01

    Full Text Available Preimplantation genetic diagnosis (PGD is a clinically feasible technology to prevent the transmission of monogenic inherited disorders in families afflicted the diseases to the future offsprings. The major technical hurdle is it does not have a general formula for all mutations, thus different gene locus needs individualized, customized design to make the diagnosis accurate enough to be applied on PGD, in which the quantity of DNA is scarce, whereas timely result is sometimes requested if fresh embryo transfer is desired. On the other hand, preimplantation genetic screening (PGS screens embryo with aneuploidy and was also known as PGD-A (A denotes aneuploidy in order to enhance the implantation rates as well as livebirth rates. In contrasts to PGD, PGS is still under ferocious debate, especially recent reports found that euploid babies were born after transferring the aneuploid embryos diagnosed by PGS back to the womb and only very few randomized trials of PGS are available in the literature. We have been doing PGD and/or PGS for more than 10 years as one of the core PGD/PGS laboratories in Taiwan. Here we provide a concise review of PGD/PGS regarding its current status, both domestically and globally, as well as its future challenges.

  5. Current status of Joint FAA/NASA Runway Friction Program

    Science.gov (United States)

    Yager, Thomas J.; Vogler, William A.

    1989-01-01

    Tests with specially instrumented NASA B-737 and FAA B-727 aircraft together with several different ground friction measuring devices have been conducted for a variety of runway surface types and wetness conditions. This effort is part of the Joint FAA/NASA Aircraft Ground Vehicle Runway Friction Program aimed at obaining a better understanding of aircraft ground handling performance under adverse weather conditions and defining relationships between aircraft and ground vehicle tire friction measurements. Aircraft braking performance on dry, wet, snow-, and ice-covered runway conditions is discussed together with ground vehicle friction data obtained under similar runway conditions. For the wet, compacted snow- and ice-covered runway conditions, the relationship between ground vehicles and aircraft friction data is identified. The influence of major test parameters on friction measurements such as speed, test tire characteristics, and surface contaminant type are discussed. The test results indicate that use of properly maintained and calibrated ground vehicles for monitoring runway friction conditions should be encouraged particularly under adverse weather conditions. The current status of the runway friction program is summarized and future test plans are identified.

  6. The SNO+ experiment. Current status and future prospects

    Energy Technology Data Exchange (ETDEWEB)

    Lozza, Valentina [Institut fuer Kern- und Teilchenphysik, Zellescher Weg 19, 01069 Dresden (Germany)

    2016-07-01

    SNO+ is a large liquid scintillator based experiment that reuses the Sudbury Neutrino Observatory detector. The detector, located 2 km underground in a mine near Sudbury, Canada, consists of a 12 m diameter acrylic vessel which will be filled with 780 tonnes of liquid scintillator. The main physics goal of SNO+ is to search for the neutrinoless double-beta (0νββ) decay of {sup 130}Te. During the double-beta phase, the liquid scintillator will be initially loaded with 0.3-0.5% natural tellurium. In 5 years of data taking, SNO+ expects to reach a sensitivity on the effective Majorana neutrino mass of 55-133 meV, just above the inverted neutrino mass hierarchy region. Recently, the possibility to deploy up to 10 times more natural tellurium has been investigated, by which SNO+ could explore deep into the parameter space for the inverted hierarchy in the near future. Designed as a general purpose neutrino experiment, SNO+ can additionally measure the reactor antineutrino oscillations, geo-neutrinos in a geologically-interesting location, watch supernova neutrinos and measure low-energy solar neutrinos. A first commissioning phase with the detector filled with water will begin soon. The scintillator phase is expected to start after few months of water data taking. The 0νββ decay phase is foreseen for the 2017. In this talk the current status and the broad physics program of SNO+ will be presented.

  7. Radiation processing in India. Current status and future program

    International Nuclear Information System (INIS)

    Mittal, Jai Pal

    2003-01-01

    Radiation processing is an alternative to conventional methods such as thermal and chemical processing in many industrial applications. In India, this technology has found extensive applications in area of healthcare, agriculture, food preservation, industry and environment. Both gamma radiation and electron beam accelerators are being utilized for this purpose. Presently, 6 commercial gamma irradiators housing about 1.5 million curie Co-60 and an annual turnover of over US$ 2 million and 3 commercial electron beam (EB) accelerators with installed capacity of 185 kW are commercially operating in India. Five demonstration plants housing a total of 0.5 million curie Co-60 have been set up to assess the techno-commercial viability of the processes such as radiation vulcanization of natural rubber latex, decontamination of spices, hygienization of sewage sludge, shelf-life extension of onions. The new areas being explored include use of electron beam treated pulp for viscose-rayon process, radiation processed 'hydrogel' burn/wound dressings and radiation processing of natural polymers. In the present paper, the current status of this program, especially the recent developments and future direction of radiation processing technology in India is reviewed. (author)

  8. Neural synchrony in cortical networks: history, concept and current status

    Directory of Open Access Journals (Sweden)

    Peter Uhlhaas

    2009-07-01

    Full Text Available Following the discovery of context-dependent synchronization of oscillatory neuronal responses in the visual system, the role of neural synchrony in cortical networks has been expanded to provide a general mechanism for the coordination of distributed neural activity patterns. In the current paper, we present an update of the status of this hypothesis through summarizing recent results from our laboratory that suggest important new insights regarding the mechanisms, function and relevance of this phenomenon. In the first part, we present recent results derived from animal experiments and mathematical simulations that provide novel explanations and mechanisms for zero and nero-zero phase lag synchronization. In the second part, we shall discuss the role of neural synchrony for expectancy during perceptual organization and its role in conscious experience. This will be followed by evidence that indicates that in addition to supporting conscious cognition, neural synchrony is abnormal in major brain disorders, such as schizophrenia and autism spectrum disorders. We conclude this paper with suggestions for further research as well as with critical issues that need to be addressed in future studies.

  9. Collagen Cross-Linking: Current Status and Future Directions

    Directory of Open Access Journals (Sweden)

    Marine Hovakimyan

    2012-01-01

    Full Text Available Collagen cross-linking (CXL using UVA light and riboflavin (vitamin B2 was introduced as a clinical application to stabilize the cornea by inducing cross-links within and between collagen fibers. CXL has been investigated extensively and has been shown clinically to arrest the progression of keratoconic or post-LASIK ectasia. With its minimal cost, simplicity, and proven positive clinical outcome, CXL can be regarded as a useful approach to reduce the number of penetrating keratoplasties performed. Small case series have also indicated that CXL is beneficial in corneal edema by reducing stromal swelling behavior and in keratitis by inhibiting pathogen growth. Despite these encouraging results, CXL remains a relatively new method that is potentially associated with complications. Aspects such as side effects and recurrence rates have still to be elucidated. In light of the growing interest in CXL, our paper summarizes present knowledge about this promising approach. We have intentionally endeavored to include the more relevant studies from the recent literature to provide an overview of the current status of CXL.

  10. High-density matter: current status and future challenges

    Directory of Open Access Journals (Sweden)

    Stone J. R.

    2015-01-01

    Full Text Available There are many fascinating processes in the Universe which we observe in more and more in detail thanks to increasingly sophisticated technology. One of the most interesting phenomena is the life cycle of stars, their birth, evolution and death. If the stars are massive enough, they end their lives in the core-collapse supernova explosion, the one of the most violent events in the Universe. As the result, the densest objects in the Universe, neutron stars and/or black holes are created. Naturally, the physical basis of these events should be understood in line with observation. The current status of our knowledge of processes in the life of stars is far from adequate for their true understanding. We show that although many models have been constructed their detailed ability to describe observations is limited or non-existent. Furthermore the general failure of all models means that we cannot tell which are heading in the right direction. A possible way forward in modeling of high-density matter is outlined, exemplified by the quark-meson-coupling model (QMC. This model has a natural explanation for the saturation of nuclear forces and depends on very few adjustable parameters, strongly constrained by the underlying physics. Latest QMC results for compact objects and finite nuclei are presented.

  11. Current status and directions for fast reactor reprocessing

    International Nuclear Information System (INIS)

    Burch, W.D.

    1983-01-01

    The development of fast breeder reactors (FBRs) for commercial electric power production has been under way in several countries for more than 20 years. In the United States (US), as elsewhere, early work was focused on small reactors to prove the feasibility of concepts and later was followed by larger reactors to test engineering features and to develop fuel technology. Because of the perceived crisis in electrical generation expected late in this century, major efforts (including fuel cycle activities) were developed in the early 1970s to ensure the capability of developing and using this new form of nuclear power. However, because of the effects of the oil price rise and subsequent emphasis on conservation, and a slowdown of industrial growth, there has been a decline in such activities, particularly in the US, which was at one time (1970s) the world leader in reactor development. This paper provides a brief history of breeder reprocessing and describes the current status, with emphasis on US programs and glimpses into the future

  12. The current status and prospect of nuclear power in China

    International Nuclear Information System (INIS)

    Wei, S.

    2014-01-01

    'Full text:' China's nuclear power development has attracted world attention. This paper presented the current status of the nuclear power plant in China. By June 30, 2014, China has 20 operational units of 18.05GWe installed capacity, taking up 1.44% of the country's total. All the units have been operating well without any events above INES Level 1 in 2013. China also has 28 units of 30.5GWe installed capacity under construction, which accounts for around 40% of that in the world. The paper presented the progress of AP1000 in China. China made a national plan for 2011 to 2020 with the target to reach 58GWe operational nuclear power and 30GWe under construction by 2020. The Chinese President Xi Jinping urged recently to speed up the approval for new builds. This paper also presented the work of 'Go Global' by Chinese nuclear companies, i.e., their development of international market. (author)

  13. Classical swine fever in India: current status and future perspective.

    Science.gov (United States)

    Singh, Vinod Kumar; Rajak, Kaushal Kishore; Kumar, Amit; Yadav, Sharad Kumar

    2018-05-04

    Classical swine fever (CSF) is a globally significant disease of swine caused by classical swine fever virus. The virus affects the wild boars and pigs of all age groups, leading to acute, chronic, late-onset or in-apparent course of the disease. The disease causes great economic loss to the piggery industry due to mortality, stunted growth, poor reproductive performance, and by impeding the international trade of pig and pig products. In India, CSF outbreaks are reported from most of the states wherever pig rearing is practiced and more frequently from northeast states. In spite of the highly devastating nature and frequent outbreaks, CSF remained underestimated and neglected for decades in India. The country requires rapid and sensitive diagnostic tests for an early detection of infection to limit the spread of the disease. Also, effective prophylactics are required to help in control and eradication of the disease for the development of the piggery industry. This review looks into the economic impact; epidemiology of CSF highlighting the temporal and spatial occurrence of outbreaks in the last two decades, circulation, and emergence of the virus genotypes in and around the country; and the constraints in the disease control, with the aim to update the knowledge of current status of the disease in India. The article also emphasizes the importance of the disease and the need to develop rapid specific diagnostics and effective measures to eradicate the disease.

  14. Veterinary pharmacology: history, current status and future prospects.

    Science.gov (United States)

    Lees, P; Fink-Gremmels, J; Toutain, P L

    2013-04-01

    Veterinary therapeutics, based on the art of Materia Medica, has been practised for countless centuries, but the science of veterinary pharmacology is of very recent origin. This review traces the contribution of Materia Medica to veterinary therapeutics from the Egyptian period through to the Age of Enlightenment. The first tentative steps in the development of the science of veterinary pharmacology were taken in the 18th century, but it was not until the mid 20th century that the science replaced the art of Materia Medica. This review traces the 20th century developments in veterinary pharmacology, with emphasis on the explosion of knowledge in the 35 year period to 2010. The range of factors which have influenced the current status of the discipline are reviewed. Future developments are considered from the perspectives of what might be regarded as desirable and those innovations that might be anticipated. We end with words of encouragement for young colleagues intent upon pursuing a career in veterinary pharmacology. © 2013 Blackwell Publishing Ltd.

  15. Thorium-based nuclear fuel: current status and perspectives

    International Nuclear Information System (INIS)

    1987-03-01

    Until the present time considerable efforts have already been made in the area of fabrication, utilization and reprocessing of Th-based fuels for different types of reactors, namely: by FRG and USA - for HTRs; FRG and Brazil, Italy - for LWRs; India - for HWRs and FBRs. Basic research of thorium fuels and thorium fuel cycles are also being undertaken by Australia, Canada, China, France, FRG, Romania, USSR and other countries. Main emphasis has been given to the utilization of thorium fuels in once-through nuclear fuel cycles, but in some projects closed thorium-uranium or thorium-plutonium fuel cycles are also considered. The purpose of the Technical Committee on the Utilization of Thorium-Based Nuclear Fuel: Current Status and Perspective was to review the world thorium resources, incentives for further exploration, obtained experience in the utilization of Th-based fuels in different types of reactors, basic research, fabrication and reprocessing of Th-based fuels. As a result of the panel discussion the recommendations on future Agency activities and list of major worldwide activities in the area of Th-based fuel were developed. A separate abstract was prepared for each of the 9 papers in this proceedings series

  16. Current Status of Periodic Safety Review of HANARO Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Minjin; Ahn, Guk-Hoon; Lee, Choong Sung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    A PSR for a research reactor became a legal requirement as the Nuclear Safety Act was amended and came into effect in 2014. This paper describes the current status and methodology of the first Periodic Safety Review (PSR) of HANARO that is being performed. The legal requirements, work plan, and process of implementing a PSR are described. Because this is the first PSR for a research reactor, it is our understating that the operating organization and regulatory body should communicate well with each other to complete the PSR in a timely manner. The first PSR of HANARO is under way. In order to achieve a successful result, activities of the operation organization such as scheduling, maintaining consistency in input data for review, and reviewing the PSR reports that will require intensive resources should be well planned. This means the operating organization needs to incorporate appropriate measures to ensure the transfer of knowledge and expertise arising from the PSR via a contractor to the operation organization. It is desirable for the Regulatory Body to be involved in all stage of the PSR to prevent any waste of resources and minimize the potential for a reworking of the PSR and the need for an additional assessment and review as recommended by foreign experts.

  17. Veterinary public health in India: current status and future needs.

    Science.gov (United States)

    Ghatak, S; Singh, B B

    2015-12-01

    Veterinary public health (VPH) assumes huge significance in developing countries such as India. However, the implementation of VPH services throughout the country is still in its infancy. From 1970 onwards, many institutes, national and international organisations, professional societies, policies and personalities have contributed towards the development of VPH in India. Nevertheless, there is an urgent need to develop VPH still further as there are many issues, such as high population density, the re-emergence of zoonotic pathogens, environmental pollution and antimicrobial resistance, that require attention. The time has surely come to involve all stakeholders, ranging from primary producers (e.g., farmers) to policy-makers, so as to garner support for the holistic implementation of VPH services in India. To improve VPH activities and services, science-based policies enforced through stringent regulation are required to improve human, animal and environmental health. The emergence of the 'One Health' concept has ushered in new hopes for the resurrection of VPH in India. Applying tools such as the World Organisation for Animal Health (OlE) Day One Competencies and the OlE Tool for the Evaluation of Performance of Veterinary Services (PVS Tool) is essential to improve the quality of national Veterinary Services and to identify gaps and weaknesses in service provision, which can be remedied to comply with the OlE international standards. VPH initiatives started modestly but they continue to grow. The present review is focused on the current status and future needs of VPH in India.

  18. The payloads of Advanced Virgo: current status and upgrades

    Science.gov (United States)

    Naticchioni, L.; Virgo Collaboration

    2018-02-01

    The development and integration of new detector payloads has been an important part of the Advanced Virgo (AdV) project, the major upgrade of the Virgo interferometric detector of Gravitational Waves, aiming to increase the detector sensitivity by one order of magnitude. During the integration phase of the new AdV payloads with monolithic suspension of mirrors we experienced systematic suspension failures later identified as caused by dust contamination of the vacuum system. In order to not postpone the detector commissioning, making possible to join the LIGO O2 observation run, the Collaboration decided to proceed with the integration of the payloads relying on steel wire suspensions for all the mirrors. In this proceeding the status of the currently integrated payloads is reported, including their angular control characterization and the Q-factor measurements for test mass steel wire suspensions. The payload upgrade for the re-integration of monolithic suspensions after the O2 run is reported in the last section.

  19. The current status of theory evaluation in nursing.

    Science.gov (United States)

    Im, Eun-Ok

    2015-10-01

    To identify the current status of theory evaluation in nursing and provide directions for theory evaluation for future development of theoretical bases of nursing discipline. Theory evaluation is an essential component in development of nursing knowledge, which is a critical element in development of nursing discipline. Despite earlier significant efforts for theory evaluation in nursing, a recent decline in the number of theory evaluation articles was noted and there have been few updates on theory evaluation in nursing. Discussion paper. A total of 58 articles published from 2003-2014 were retrieved through searches using the PUBMED, PsyInfo and CINAHL. The articles were sorted by the area of evaluation and analysed to identify themes reflecting the theory evaluation process. Diverse ways of theory evaluation need to be continuously used in future theory evaluation efforts. Six themes reflecting the theory evaluation process were identified: (a) rarely using existing theory evaluation criteria; (b) evaluating specifics; (c) using various statistical analysis methods; (d) developing instruments; (e) adopting in practice and education; and (f) evaluating mainly middle-range theories and situation-specific theories. © 2015 John Wiley & Sons Ltd.

  20. Controlling the HIV/AIDS epidemic: current status and global challenges

    Directory of Open Access Journals (Sweden)

    Thorsten eDemberg

    2012-08-01

    Full Text Available This review provides an overview of the current status of the global HIV pandemic and strategies to bring it under control. It updates numerous preventive approaches including behavioral interventions, male circumcision, pre- and post-exposure prophylaxis, vaccines, and microbicides. The manuscript summarizes current anti-retroviral treatment options, their impact in the western world, and difficulties faced by emerging and resource-limited nations in providing and maintaining appropriate treatment regimens. Current clinical and pre-clinical approaches towards a cure for HIV are described, including new drug compounds that target viral reservoirs and gene therapy approaches aimed at altering susceptibility to HIV infection. Recent progress in vaccine development is summarized, including novel approaches and new discoveries.

  1. Current status of knowledge on public-speaking anxiety.

    Science.gov (United States)

    Pull, Charles B

    2012-01-01

    This review examines the current knowledge on public-speaking anxiety, that is, the fear of speaking in front of others. This article summarizes the findings from previous review articles and describes new research findings on basic science aspects, prevalence rates, classification, and treatment that have been published between August 2008 and August 2011. Recent findings highlight the major aspects of psychological and physiological reactivity to public speaking in individuals who are afraid to speak in front of others, confirm high prevalence rates of the disorder, contribute to identifying the disorder as a possibly distinct subtype of social anxiety disorder (SAD), and give support to the efficacy of treatment programs using virtual reality exposure and Internet-based self-help. Public-speaking anxiety is a highly prevalent disorder, leading to excessive psychological and physiological reactivity. It is present in a majority of individuals with SAD and there is substantial evidence that it may be a distinct subtype of SAD. It is amenable to treatment including, in particular, new technologies such as exposure to virtual environments and the use of cognitive-behavioral self-help programs delivered on the Internet.

  2. Emerging memories: resistive switching mechanisms and current status

    International Nuclear Information System (INIS)

    Jeong, Doo Seok; Thomas, Reji; Katiyar, R S; Scott, J F; Kohlstedt, H; Petraru, A; Hwang, Cheol Seong

    2012-01-01

    The resistance switching behaviour of several materials has recently attracted considerable attention for its application in non-volatile memory (NVM) devices, popularly described as resistive random access memories (RRAMs). RRAM is a type of NVM that uses a material(s) that changes the resistance when a voltage is applied. Resistive switching phenomena have been observed in many oxides: (i) binary transition metal oxides (TMOs), e.g. TiO 2 , Cr 2 O 3 , FeO x and NiO; (ii) perovskite-type complex TMOs that are variously functional, paraelectric, ferroelectric, multiferroic and magnetic, e.g. (Ba,Sr)TiO 3 , Pb(Zr x Ti 1−x )O 3 , BiFeO 3 and Pr x Ca 1−x MnO 3 ; (iii) large band gap high-k dielectrics, e.g. Al 2 O 3 and Gd 2 O 3 ; (iv) graphene oxides. In the non-oxide category, higher chalcogenides are front runners, e.g. In 2 Se 3 and In 2 Te 3 . Hence, the number of materials showing this technologically interesting behaviour for information storage is enormous. Resistive switching in these materials can form the basis for the next generation of NVM, i.e. RRAM, when current semiconductor memory technology reaches its limit in terms of density. RRAMs may be the high-density and low-cost NVMs of the future. A review on this topic is of importance to focus concentration on the most promising materials to accelerate application into the semiconductor industry. This review is a small effort to realize the ambitious goal of RRAMs. Its basic focus is on resistive switching in various materials with particular emphasis on binary TMOs. It also addresses the current understanding of resistive switching behaviour. Moreover, a brief comparison between RRAMs and memristors is included. The review ends with the current status of RRAMs in terms of stability, scalability and switching speed, which are three important aspects of integration onto semiconductors. (review article)

  3. Emerging memories: resistive switching mechanisms and current status

    Science.gov (United States)

    Jeong, Doo Seok; Thomas, Reji; Katiyar, R. S.; Scott, J. F.; Kohlstedt, H.; Petraru, A.; Hwang, Cheol Seong

    2012-07-01

    The resistance switching behaviour of several materials has recently attracted considerable attention for its application in non-volatile memory (NVM) devices, popularly described as resistive random access memories (RRAMs). RRAM is a type of NVM that uses a material(s) that changes the resistance when a voltage is applied. Resistive switching phenomena have been observed in many oxides: (i) binary transition metal oxides (TMOs), e.g. TiO2, Cr2O3, FeOx and NiO; (ii) perovskite-type complex TMOs that are variously functional, paraelectric, ferroelectric, multiferroic and magnetic, e.g. (Ba,Sr)TiO3, Pb(Zrx Ti1-x)O3, BiFeO3 and PrxCa1-xMnO3 (iii) large band gap high-k dielectrics, e.g. Al2O3 and Gd2O3; (iv) graphene oxides. In the non-oxide category, higher chalcogenides are front runners, e.g. In2Se3 and In2Te3. Hence, the number of materials showing this technologically interesting behaviour for information storage is enormous. Resistive switching in these materials can form the basis for the next generation of NVM, i.e. RRAM, when current semiconductor memory technology reaches its limit in terms of density. RRAMs may be the high-density and low-cost NVMs of the future. A review on this topic is of importance to focus concentration on the most promising materials to accelerate application into the semiconductor industry. This review is a small effort to realize the ambitious goal of RRAMs. Its basic focus is on resistive switching in various materials with particular emphasis on binary TMOs. It also addresses the current understanding of resistive switching behaviour. Moreover, a brief comparison between RRAMs and memristors is included. The review ends with the current status of RRAMs in terms of stability, scalability and switching speed, which are three important aspects of integration onto semiconductors.

  4. Nanomedicines for renal disease: current status and future applications

    DEFF Research Database (Denmark)

    Kamaly, Nazila; He, John C.; Ausiello, Dennis A.

    2016-01-01

    , alongside research efforts in tissue regeneration and organ-on-a-chip investigations, are likely to provide novel solutions to treat kidney diseases. Our understanding of renal anatomy and of how the biological and physico-chemical properties of nanomedicines (the combination of a nanocarrier and a drug......Treatment and management of kidney disease currently presents an enormous global burden, and the application of nanotechnology principles to renal disease therapy, although still at an early stage, has profound transformative potential. The increasing translation of nanomedicines to the clinic......) influence their interactions with renal tissues has improved dramatically. Tailoring of nanomedicines in terms of kidney retention and binding to key membranes and cell populations associated with renal diseases is now possible and greatly enhances their localization, tolerability, and efficacy. This Review...

  5. Current and Future Status of Diversity in Ophthalmologist Workforce.

    Science.gov (United States)

    Xierali, Imam M; Nivet, Marc A; Wilson, M Roy

    2016-09-01

    Increasing the level of diversity among ophthalmologists may help reduce disparities in eye care. To assess the current and future status of diversity among ophthalmologists in the workforce by sex, race, and ethnicity in the context of the available number of medical students in the United States. Data from the Association of American Medical Colleges, the American Medical Association, and US Census were used to evaluate the differences and trends in diversity among ophthalmologists, all full-time faculty except ophthalmology, ophthalmology faculty, ophthalmology residents, medical school students, and the US population between 2005 and 2015. For 2014, associations of sex, race, and ethnicity with physician practice locations were assessed. Proportions of ophthalmologists stratified by sex, race, and ethnicity between 2005 and 2015. Women and minority groups traditionally underrepresented in medicine (URM)-black, Hispanic, American Indian, Alaskan Native, Native Hawaiian, and Pacific Islander-were underrepresented as practicing ophthalmologists (22.7% and 6%, respectively), ophthalmology faculty (35.1% and 5.7%, respectively), and ophthalmology residents (44.3% and 7.7%, respectively), compared with the US population (50.8% and 30.7%, respectively). During the past decade, there had been a modest increase in the proportion of female practicing ophthalmologists who graduated from US medical schools in 1980 or later (from 23.8% to 27.1%; P workforce despite an available pool of medical students. Given the prevalent racial and ethnic disparities in eye care and an increasingly diverse society, future research and training efforts that increase the level of diversity among medical students and residents seems warranted.

  6. Neutron star matter equation of state: current status and challenges

    Science.gov (United States)

    Ohnishi, Akira

    2014-09-01

    Neutron star matter has a variety of constituents and structures depending on the density; neutron-rich nuclei surounded by electrons and drip neutrons in the crust, pasta nuclei at the bottom of inner crust, and uniform isospin-asymmetric nuclear matter in a superfluid state in the outer core. In the inner core, the neutron Fermi energy becomes so large that exotic constituents such as hyperons, mesons and quarks may emerge. Radioactive beam and hypernuclear experiments provide information on the symmetry energy and superfluidity in the crust and outer core and on the hyperon potentials in the inner core, respectively. Cold atom experiments are also helpful to understand pure neutron matter, which may be simulated by the unitary gas. An equation of state (EOS) constructed based on these laboratory experiments has to be verified by the astronomical observations such as the mass, radius, and oscillations of neutron stars. One of the key but missing ingredients is the three-baryon interactions such as the hyperon-hyperon-nucleon (YYN) interaction. YYN interaction is important in order to explain the recently discovered massive neutron stars consistently with laboratory experiments. We have recently found that the ΛΛ interaction extracted from the ΛΛ correlation at RHIC is somewhat stronger than that from double Λ hypernuclei. Since these two interactions corresponds to the vacuum and in-medium ΛΛ interactions, respectively, the difference may tell us a possible way to access the YYN interaction based on experimental data. In the presentation, after a review on the current status of neutron star matter EOS studies, we discuss the necessary tasks to pin down the EOS. We also present our recent study of ΛΛ interaction from correlation data at RHIC.

  7. Livestock in biomedical research: history, current status and future prospective.

    Science.gov (United States)

    Polejaeva, Irina A; Rutigliano, Heloisa M; Wells, Kevin D

    2016-01-01

    Livestock models have contributed significantly to biomedical and surgical advances. Their contribution is particularly prominent in the areas of physiology and assisted reproductive technologies, including understanding developmental processes and disorders, from ancient to modern times. Over the past 25 years, biomedical research that traditionally embraced a diverse species approach shifted to a small number of model species (e.g. mice and rats). The initial reasons for focusing the main efforts on the mouse were the availability of murine embryonic stem cells (ESCs) and genome sequence data. This powerful combination allowed for precise manipulation of the mouse genome (knockouts, knockins, transcriptional switches etc.) leading to ground-breaking discoveries on gene functions and regulation, and their role in health and disease. Despite the enormous contribution to biomedical research, mouse models have some major limitations. Their substantial differences compared with humans in body and organ size, lifespan and inbreeding result in pronounced metabolic, physiological and behavioural differences. Comparative studies of strategically chosen domestic species can complement mouse research and yield more rigorous findings. Because genome sequence and gene manipulation tools are now available for farm animals (cattle, pigs, sheep and goats), a larger number of livestock genetically engineered (GE) models will be accessible for biomedical research. This paper discusses the use of cattle, goats, sheep and pigs in biomedical research, provides an overview of transgenic technology in farm animals and highlights some of the beneficial characteristics of large animal models of human disease compared with the mouse. In addition, status and origin of current regulation of GE biomedical models is also reviewed.

  8. Current Status of Nursing Informatics Education in Korea

    Science.gov (United States)

    Jeon, Eunjoo; Kim, Jeongeun; Lee, Ji-Hyun; Kim, Jungha; Jin, Meiling; Ahn, Shinae; Jun, Jooyeon; Song, Healim; On, Jeongah; Jung, Hyesil; Hong, Yeong Joo; Yim, Suran

    2016-01-01

    Objectives This study presents the current status of nursing informatics education, the content covered in nursing informatics courses, the faculty efficacy, and the barriers to and additional supports for teaching nursing informatics in Korea. Methods A set of questionnaires consisting of an 18-item questionnaire for nursing informatics education, a 6-item questionnaire for faculty efficacy, and 2 open-ended questions for barriers and additional supports were sent to 204 nursing schools via email and the postal service. Nursing schools offering nursing informatics were further asked to send their syllabuses. The subjects taught were analyzed using nursing informatics competency categories and other responses were tailed using descriptive statistics. Results A total of 72 schools (35.3%) responded to the survey, of which 38 reported that they offered nursing informatics courses in their undergraduate nursing programs. Nursing informatics courses at 11 schools were taught by a professor with a degree majoring in nursing informatics. Computer technology was the most frequently taught subject (27 schools), followed by information systems used for practice (25 schools). The faculty efficacy was 3.76 ± 0.86 (out of 5). The most frequently reported barrier to teaching nursing informatics (n = 9) was lack of awareness of the importance of nursing informatics. Training and educational opportunities was the most requested additional support. Conclusions Nursing informatics education has increased during the last decade in Korea. However, the proportions of faculty with degrees in nursing informatics and number of schools offering nursing informatics courses have not increased much. Thus, a greater focus is needed on training faculty and developing the courses. PMID:27200224

  9. Current Status of Nursing Informatics Education in Korea.

    Science.gov (United States)

    Jeon, Eunjoo; Kim, Jeongeun; Park, Hyeoun-Ae; Lee, Ji-Hyun; Kim, Jungha; Jin, Meiling; Ahn, Shinae; Jun, Jooyeon; Song, Healim; On, Jeongah; Jung, Hyesil; Hong, Yeong Joo; Yim, Suran

    2016-04-01

    This study presents the current status of nursing informatics education, the content covered in nursing informatics courses, the faculty efficacy, and the barriers to and additional supports for teaching nursing informatics in Korea. A set of questionnaires consisting of an 18-item questionnaire for nursing informatics education, a 6-item questionnaire for faculty efficacy, and 2 open-ended questions for barriers and additional supports were sent to 204 nursing schools via email and the postal service. Nursing schools offering nursing informatics were further asked to send their syllabuses. The subjects taught were analyzed using nursing informatics competency categories and other responses were tailed using descriptive statistics. A total of 72 schools (35.3%) responded to the survey, of which 38 reported that they offered nursing informatics courses in their undergraduate nursing programs. Nursing informatics courses at 11 schools were taught by a professor with a degree majoring in nursing informatics. Computer technology was the most frequently taught subject (27 schools), followed by information systems used for practice (25 schools). The faculty efficacy was 3.76 ± 0.86 (out of 5). The most frequently reported barrier to teaching nursing informatics (n = 9) was lack of awareness of the importance of nursing informatics. Training and educational opportunities was the most requested additional support. Nursing informatics education has increased during the last decade in Korea. However, the proportions of faculty with degrees in nursing informatics and number of schools offering nursing informatics courses have not increased much. Thus, a greater focus is needed on training faculty and developing the courses.

  10. Phytochemicals for breast cancer therapy: current status and future implications.

    Science.gov (United States)

    Siddiqui, Jawed Akhtar; Singh, Aru; Chagtoo, Megha; Singh, Nidhi; Godbole, Madan Madhav; Chakravarti, Bandana

    2015-01-01

    Breast cancer is one of the most common malignancies among women, representing nearly 30% of newly diagnosed cancers every year. Till date, various therapeutic interventions, including surgery, chemotherapy, hormonal therapy, and radiotherapy are available and are known to cause a significant decline in the overall mortality rate. However, therapeutic resistance, recurrence and lack of treatment in metastasis are the major challenges that need to be addressed. Increasing evidence suggests the presence of cancer stem cells (CSCs) in heterogeneous population of breast tumors capable of selfrenewal and differentiation and is considered to be responsible for drug resistance and recurrence. Therefore, compound that can target both differentiated cancer cells, as well as CSCs, may provide a better treatment strategy. Due to safe nature of dietary agents and health products, investigators are introducing them into clinical trials in place of chemotherapeutic agents.This current review focuses on phytochemicals, mainly flavonoids that are in use for breast cancer therapy in preclinical phase. As phytochemicals have several advantages in breast cancer and cancer stem cells, new synthetic series for breast cancer therapy from analogues of most potent natural molecule can be developed via rational drug design approach.

  11. Neuroprotection for Stroke: Current Status and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Christoph Kleinschnitz

    2012-09-01

    Full Text Available Neuroprotection aims to prevent salvageable neurons from dying. Despite showing efficacy in experimental stroke studies, the concept of neuroprotection has failed in clinical trials. Reasons for the translational difficulties include a lack of methodological agreement between preclinical and clinical studies and the heterogeneity of stroke in humans compared to homogeneous strokes in animal models. Even when the international recommendations for preclinical stroke research, the Stroke Academic Industry Roundtable (STAIR criteria, were followed, we have still seen limited success in the clinic, examples being NXY-059 and haematopoietic growth factors which fulfilled nearly all the STAIR criteria. However, there are a number of neuroprotective treatments under investigation in clinical trials such as hypothermia and ebselen. Moreover, promising neuroprotective treatments based on a deeper understanding of the complex pathophysiology of ischemic stroke such as inhibitors of NADPH oxidases and PSD-95 are currently evaluated in preclinical studies. Further concepts to improve translation include the investigation of neuroprotectants in multicenter preclinical Phase III-type studies, improved animal models, and close alignment between clinical trial and preclinical methodologies. Future successful translation will require both new concepts for preclinical testing and innovative approaches based on mechanistic insights into the ischemic cascade.

  12. Current status in remnant gastric cancer after distal gastrectomy

    Science.gov (United States)

    Ohira, Masaichi; Toyokawa, Takahiro; Sakurai, Katsunobu; Kubo, Naoshi; Tanaka, Hiroaki; Muguruma, Kazuya; Yashiro, Masakazu; Onoda, Naoyoshi; Hirakawa, Kosei

    2016-01-01

    Remnant gastric cancer (RGC) and gastric stump cancer after distal gastrectomy (DG) are recognized as the same clinical entity. In this review, the current knowledges as well as the non-settled issues of RGC are presented. Duodenogastric reflux and denervation of the gastric mucosa are considered as the two main factors responsible for the development of RGC after benign disease. On the other hand, some precancerous circumstances which already have existed at the time of initial surgery, such as atrophic gastritis and intestinal metaplasia, are the main factors associated with RGC after gastric cancer. Although eradication of Helicobacter pylori (H. pylori) in remnant stomach is promising, it is still uncertain whether it can reduce the risk of carcinogenesis. Periodic endoscopic surveillance after DG was reported useful in detecting RGC at an early stage, which offers a chance to undergo minimally invasive endoscopic treatment or laparoscopic surgery and leads to an improved prognosis in RGC patients. Future challenges may be expected to elucidate the benefit of eradication of H. pylori in the remnant stomach if it could reduce the risk for RGC, to build an optimal endoscopic surveillance strategy after DG by stratifying the risk for development of RGC, and to develop a specific staging system for RGC for the standardization of the treatment by prospecting the prognosis. PMID:26937131

  13. Chemoradiotherapy for uterine cancer. Current status and perspectives

    International Nuclear Information System (INIS)

    Kuzuya, Kazuo

    2004-01-01

    The conventional local treatment methods (surgery and radiation) for cervical cancer have reached a plateau in terms of survival benefit and, therefore, in this review, new treatment strategies (combined chemotherapy [CT] and local therapy) to overcome the poor prognosis were examined in high-risk groups. The effectiveness of neoadjuvant chemotherapy (NAC) administered prior to radiotherapy (RT) has not been confirmed for any disease stages. But NAC followed by surgery may improve survival in patients with stage Ib2 compared with surgery alone; and in patients with stage Ib2 to IIB compared with RT alone. Five large randomized clinical trials (RCTs) demonstrated a significant survival benefit for patients treated with concurrent chemoradiotherapy (CCRT), using a cisplatin (CDDP)-based regimen, with a 28%-50% relative reduction in the risk of death. In addition, the results of a meta-analysis of 19 RCTs of CCRT (1981-2000) involving 4580 patients showed that CCRT significantly improved overall survival (OS) hazard ratio ([HR] 0.71; P<0.0001), as well as progression-free survival (PFS; HR 0.61; P<0.0001). In line with these results, CCRT is currently recommended as standard therapy for advanced cancer (stage III/IVA) in the United States. However, there remains much controversy and uncertainty regarding the optimal therapeutic approaches, especially for patients with advanced cancer. Additional RCTs should be conducted to find the optimal CT regimen and RT for Japanese patients, considering acute and late complications, as well as differences in pelvic anatomy, total radiation dose, and RT procedures between Japan and other countries. Evidence obtained from such studies should establish the optimal CCRT treatment protocol and define the patient population (disease stage) that the protocol really benefits. (author)

  14. The current status of forensic science laboratory accreditation in Europe.

    Science.gov (United States)

    Malkoc, Ekrem; Neuteboom, Wim

    2007-04-11

    Forensic science is gaining some solid ground in the area of effective crime prevention, especially in the areas where more sophisticated use of available technology is prevalent. All it takes is high-level cooperation among nations that can help them deal with criminality that adopts a cross-border nature more and more. It is apparent that cooperation will not be enough on its own and this development will require a network of qualified forensic laboratories spread over Europe. It is argued in this paper that forensic science laboratories play an important role in the fight against crime. Another, complimentary argument is that forensic science laboratories need to be better involved in the fight against crime. For this to be achieved, a good level of cooperation should be established and maintained. It is also noted that harmonization is required for such cooperation and seeking accreditation according to an internationally acceptable standard, such as ISO/IEC 17025, will eventually bring harmonization as an end result. Because, ISO/IEC 17025 as an international standard, has been a tool that helps forensic science laboratories in the current trend towards accreditation that can be observed not only in Europe, but also in the rest of the world of forensic science. In the introduction part, ISO/IEC 17025 states that "the acceptance of testing and calibration results between countries should be facilitated if laboratories comply with this international standard and if they obtain accreditation from bodies which have entered into mutual recognition agreements with equivalent bodies in other countries using this international standard." Furthermore, it is emphasized that the use of this international standard will assist in the harmonization of standards and procedures. The background of forensic science cooperation in Europe will be explained by using an existing European forensic science network, i.e. ENFSI, in order to understand the current status of forensic

  15. Current and Under Development Treatment Modalities of Psoriasis: A Review.

    Science.gov (United States)

    Albaghdadi, Abdullah

    2017-01-01

    Psoriasis is a chronic and complex autoimmune inflammatory skin disease that affects over 125 million people worldwide. It can exhibit at any age, in spite of the fact that children are less normally influenced than adults. It is characterized by distinct erythematous plaques shielded with conspicuous silvery scales that shows up in different areas of the skin. Knowledge of pathophysiology, especially the pathogenesis of psoriasis, has significantly progressed in the recent decade. Advancement in molecular knowledge leads to better understanding of the disease, thus influencing the development of efficient treatment modalities. However, even with the availability of various options of treatment most of the efficient treatment modalities are costly. Expenses of health care bring about major financial weight to the patients as well as to health care systems. Thus, it was important to review the available current treatment options and those which are under development, in terms of efficacy, safety and cost to assist in selecting the most appropriate treatment for psoriasis patients. Literatures were searched by using key words psoriasis, topical treatment, systemic treatment, biologics and phototherapies, on Embase, Medline, Jstor, Cochrane and Merck Index databases. Life-style choices such as smoking, alcohol consumption, obesity and stress are recognised as risk factors and triggers associated with psoriasis. Psoriasis poses psycho-social and economic burden on affected patients that sometimes leads to depression, reduced social interaction and suicidal tendencies in patients. Depending on the type, severity and extent of the disease, comorbidities, patient preference, efficacy and safety profile, numerous treatment modalities and therapeutic agents are available such as topical, systemic, biologic and phototherapeutic treatments. However, it was found that among all the current available treatments for psoriasis, biologic agents and phototherapeutic modalities are

  16. Policies for second generation biofuels: current status and future challenges

    Energy Technology Data Exchange (ETDEWEB)

    Egger, Haakan; Greaker, Mads; Potter, Emily

    2011-07-01

    Current state-of-the-art knowledge concludes that green house gas (GHG) emissions must be controlled and reduced within the next 30-40 years. The transport sector contributes almost a fifth of the current global emissions, and its share is likely to increase in the future. The US and a number of European countries have therefore introduced various support schemes for research and development (RandD) of low emission fuels that can potentially replace the current fossil fuels. One such alternative is biofuels. The advantage of biofuels are that it is easy to introduce into the transport sector. On the other hand, recent research papers question whether the supply of feedstock is sufficient, and to what extent biofuels lead to GHG emission reductions. This report reviews the current status of second generation biofuels. Second generation biofuels are made from cellulose, which according to our survey of the literature, is in more abundant supply than the first generation biofuels feedstocks. Furthermore, it seems to have the potential to reduce GHG emissions from the transport sector without leading to devastating land use changes, which recent critique has held against first generation biofuels. Given that governments have decided to support RandD of low emission fuels, we ask the following questions: Should second generation biofuels receive RandD support to the same extent as other low emission fuels like hydrogen? How should support schemes for second generation biofuels be designed? Second generation biofuels can be divided according to the production process into thermo-chemical and bio-chemical. With respect to the thermo-chemical process the potential for cost reductions seems to be low. On the other hand, ethanol made from cellulose using the biochemical conversion process is far from a ripe technology. Expert reports point to several potential technological breakthroughs which may reduce costs substantially. Hence, cellulosic ethanol, should receive direct

  17. Assessing the nutritional status of beef cattle: current practices and ...

    African Journals Online (AJOL)

    SERVER

    2007-12-17

    Dec 17, 2007 ... Key words: Body condition scoring, blood metabolites, nutritional status, cattle. INTRODUCTION ... reproductive performance and good walking and foraging ..... the gastrointestinal tract while mobilization is increased in.

  18. Review of mercury pollution in South Africa: current status

    CSIR Research Space (South Africa)

    Walters, Chavon R

    2011-08-01

    Full Text Available The present paper is a review on the status of mercury (Hg) as a pollutant in South African aquatic ecosystems. Spatial patterns of Hg distribution and bioaccumulation in water resources were investigated by collecting and analyzing multimedia...

  19. The current status of utilization of research reactors in China

    International Nuclear Information System (INIS)

    Luzheng, Yuan

    2004-01-01

    Seminars on utilization of research reactors were held to enhance experience exchanging among institutes and universities in China. The status of CARR (China Advanced Research Reactor) project is briefly described. The progress in BNCT program in China is introduced. (author)

  20. Assessment of the current status of basic nuclear data compilations

    International Nuclear Information System (INIS)

    1985-01-01

    Topics discussed include: the status of mass-chain evaluations, remote terminal access, other US Nuclear Data Network publications, formats and procedures subcommittee report, keyword follow-up (Phys. Rev. C), and atomic data and nuclear data tables

  1. Current Status and Prediction on Development of PE Market

    Institute of Scientific and Technical Information of China (English)

    Yu Jiao

    2003-01-01

    This article comprehensively analyzes the status of market demand/supply and import/export volumes of PE in the world and in China, and predicts the future development trends in the fields of PE production and consumption.

  2. New Molecular Targets of Anticancer Therapy - Current Status and Perspectives.

    Science.gov (United States)

    Zajac, Marianna; Muszalska, Izabela; Jelinska, Anna

    2016-01-01

    Molecularly targeted anticancer therapy involves the use of drugs or other substances affecting specific molecular targets that play a part in the development, progression and spread of a given neoplasm. By contrast, the majority of classical chemotherapeutics act on all rapidly proliferating cells, both healthy and cancerous ones. Target anticancer drugs are designed to achieve a particular aim and they usually act cytostatically, not cytotoxically like classical chemotherapeutics. At present, more than 300 biological molecular targets have been identified. The proteins involved in cellular metabolism include (among others) receptor proteins, signal transduction proteins, mRNA thread matrix synthesis proteins participating in neoplastic transformation, cell cycle control proteins, functional and structural proteins. The receptor proteins that are targeted by currently used anticancer drugs comprise the epithelial growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor(VEGFR). Target anticancer drugs may affect extracellular receptor domains (antibodies) or intracellular receptor domains (tyrosine kinase inhibitors). The blocking of the mRNA thread containing information about the structure of oncogenes (signal transduction proteins) is another molecular target of anticancer drugs. That type of treatment, referred to as antisense therapy, is in clinical trials. When the synthesis of genetic material is disturbed, in most cases the passage to the next cycle phase is blocked. The key proteins responsible for the blockage are cyclines and cycline- dependent kinases (CDK). Clinical trials are focused on natural and synthetic substances capable of blocking various CDKs. The paper discusses the molecular targets and chemical structure of target anticancer drugs that have been approved for and currently applied in antineoplastic therapy together with indications and contraindications for their

  3. Perceived oral health status and treatment needs of dental auxiliaries

    African Journals Online (AJOL)

    Abstract. Objective: To determine the perceived oral health status and treatment needs of Nigerian dental therapists in students from Federal School of Dental Therapy and Technology Enugu, Nigeria was conducted using self-administered questionnaire to obtain information on demography, self-reported oral health status, ...

  4. The current status of laser applications in dentistry.

    Science.gov (United States)

    Walsh, L J

    2003-09-01

    A range of lasers is now available for use in dentistry. This paper summarizes key current and emerging applications for lasers in clinical practice. A major diagnostic application of low power lasers is the detection of caries, using fluorescence elicited from hydroxyapatite or from bacterial by-products. Laser fluorescence is an effective method for detecting and quantifying incipient occlusal and cervical carious lesions, and with further refinement could be used in the same manner for proximal lesions. Photoactivated dye techniques have been developed which use low power lasers to elicit a photochemical reaction. Photoactivated dye techniques can be used to disinfect root canals, periodontal pockets, cavity preparations and sites of peri-implantitis. Using similar principles, more powerful lasers can be used for photodynamic therapy in the treatment of malignancies of the oral mucosa. Laser-driven photochemical reactions can also be used for tooth whitening. In combination with fluoride, laser irradiation can improve the resistance of tooth structure to demineralization, and this application is of particular benefit for susceptible sites in high caries risk patients. Laser technology for caries removal, cavity preparation and soft tissue surgery is at a high state of refinement, having had several decades of development up to the present time. Used in conjunction with or as a replacement for traditional methods, it is expected that specific laser technologies will become an essential component of contemporary dental practice over the next decade.

  5. Juvenile fibromyalgia: current status of research and future developments

    Science.gov (United States)

    Kashikar-Zuck, Susmita; Ting, Tracy V.

    2015-01-01

    Juvenile-onset fibromyalgia (JFM) is a poorly understood chronic pain condition most commonly affecting adolescent girls. The condition is characterized by widespread musculoskeletal pain and other associated symptoms, including fatigue, nonrestorative sleep, headaches, irritable bowel symptoms, dysautonomia and mood disorders such as anxiety and/or depression. In the past few years, there has been a greater focus on understanding JFM in adolescents. Research studies have provided insight into the clinical characteristics of this condition and its effect on both short-term and long-term psychosocial and physical functioning. The importance of early and effective intervention is being recognized, as research has shown that symptoms of JFM tend to persist and do not resolve over time as was previously believed. Efforts to improve treatments for JFM are underway, and new evidence strongly points to the potential benefits of cognitive–behavioural therapy on improving mood and daily functioning. Research into pharmacotherapy and other nonpharmacological options is in progress. Advancements in the understanding of adult fibromyalgia have paved the way for future studies on diagnosis, assessment and management of JFM. This Review focuses on our current knowledge of the condition, provides an update of the latest research advances, and highlights areas for further study. PMID:24275966

  6. Cangrelor in Percutaneous Coronary Intervention: Current Status and Perspectives.

    Science.gov (United States)

    Alexopoulos, Dimitrios; Pappas, Christos; Sfantou, Danai; Lekakis, John

    2018-01-01

    Cangrelor is an intravenously administered P2Y 12 receptor antagonist with very fast, potent, and quickly reversible action. In the CHAMPION PHOENIX trial, cangrelor provided an improved anti-ischemic protection compared with clopidogrel, without increasing the risk of severe bleeding. Cangrelor is currently approved by drug regulating authorities for patients undergoing percutaneous coronary intervention (PCI) without prior treatment with a P2Y 12 receptor antagonist and not receiving a glycoprotein IIb/IIIa inhibitor, while its use is endorsed with a class IIb recommendation by the European Society of Cardiology guidelines. Several subanalyses of CHAMPION PHOENIX trial have tried to elucidate the role of cangrelor in PCI, including its usefulness during a 2-hour landmark analysis, impact on intraprocedural stent thrombosis, and reduction in myocardial infarction (MI) rate. The influence of gender, geographic region, access site, and bivalirudin use on cangrelor's effects has also been reported. In patients with ST elevation MI and in clinical scenarios of disturbed absorption of oral antiplatelet agents or in need of an intravenous agent, cangrelor may surpass oral agents' drawbacks. Transitioning to an oral agent is mandatory following cangrelor infusion discontinuation, although ticagrelor may be administered earlier without any pharmacodynamic interaction. Nevertheless, the clinical role of cangrelor in conjunction with administration of prasugrel or ticagrelor remains unclear. Accruing real-life experience is expected to improve our understanding of cangrelor's role in everyday clinical practice.

  7. Nanotechnology in neurology: Genesis, current status, and future prospects

    Directory of Open Access Journals (Sweden)

    Paurush Ambesh

    2015-01-01

    Full Text Available Nanotechnology is a promising, novel field of technological development. There is great potential in research and clinical applications for neurological diseases. Here we chronicle the inception of nanotechnology, discuss its integration with neurology, and highlight the challenges in current application. Some of the problems involving practical use of neuronanotechnology are direct biological toxicity, visualization of the nanodevice, and the short life expectancy of nanomachinery. Neuron cell therapy is an upcoming field for the treatment of challenging problems in neurology. Peptide nanofibers based on amphiphilic molecules have been developed that can autoregulate their structure depending on the conditions of the surrounding milieu. Such frameworks are promising for serving as drug delivery systems or communication bridges between damaged neurons. For common disabling diseases such as Alzheimer′s disease (AD, Parkinson′s disease (PD, amyotrophic lateral sclerosis (ALS, and multiple sclerosis (MS, recent developments have seen revolutionary nanotech-based novelties, which are discussed here in detail. Bioimaging integrated with nanoneuromedicine has opened up new doors for cancer and infection therapeutics.

  8. Acute myeloid leukemia in children: Current status and future directions.

    Science.gov (United States)

    Taga, Takashi; Tomizawa, Daisuke; Takahashi, Hiroyuki; Adachi, Souichi

    2016-02-01

    Acute myeloid leukemia (AML) accounts for 25% of pediatric leukemia and affects approximately 180 patients annually in Japan. The treatment outcome for pediatric AML has improved through advances in chemotherapy, hematopoietic stem cell transplantation (HSCT), supportive care, and optimal risk stratification. Currently, clinical pediatric AML studies are conducted separately according to the AML subtypes: de novo AML, acute promyelocytic leukemia (APL), and myeloid leukemia with Down syndrome (ML-DS). Children with de novo AML are treated mainly with anthracyclines and cytarabine, in some cases with HSCT, and the overall survival (OS) rate now approaches 70%. Children with APL are treated with an all-trans retinoic acid (ATRA)-combined regimen with an 80-90% OS. Children with ML-DS are treated with a less intensive regimen compared with non-DS patients, and the OS is approximately 80%. HSCT in first remission is restricted to children with high-risk de novo AML only. To further improve outcomes, it will be necessary to combine more accurate risk stratification strategies using molecular genetic analysis with assessment of minimum residual disease, and the introduction of new drugs in international collaborative clinical trials. © 2015 Japan Pediatric Society.

  9. Metabolic syndrome in the Mediterranean region: Current status

    Directory of Open Access Journals (Sweden)

    Panagiotis Anagnostis

    2012-01-01

    Full Text Available Metabolic syndrome (MetS is a cluster of metabolic abnormalities including abdominal obesity, impaired fasting glucose, hypertension and dyslipidemia. It seems to affect about one-fourth to one-fifth of the Mediterranean population, and its prevalence increases with age, being similar for both sexes and depending on the region and the definition used, with the National Cholesterol Education Program-Adult Treatment Panel-III (NCEP-ATPIII definition being the most effective in the identification of glucose intolerance and cardiovascular risk. Except for these, MetS is associated with fatty liver disease, some forms of cancer, hypogonadism, and vascular dementia. The Mediterranean diet seems to be an ideal diet in patients with MetS, being rich in fibre, monounsaturated and polyunsaturated fats, and low in animal protein; and decreases the prevalence of MetS and cardiovascular disease risk. Except for weight loss, multifactorial intervention including insulin resistance reduction and normoglycemia, management of dyslipidemia, optimizing blood pressure and administration of low-dose aspirin for patients at high or moderately high cardiovascular disease (CVD risk are additional targets. The present review provides current understanding about MetS in the Mediterranean region, focusing on its prevalence, clinical significance, and therapeutic strategy.

  10. Metabolic syndrome in the Mediterranean region: Current status.

    Science.gov (United States)

    Anagnostis, Panagiotis

    2012-01-01

    Metabolic syndrome (MetS) is a cluster of metabolic abnormalities including abdominal obesity, impaired fasting glucose, hypertension and dyslipidemia. It seems to affect about one-fourth to one-fifth of the Mediterranean population, and its prevalence increases with age, being similar for both sexes and depending on the region and the definition used, with the National Cholesterol Education Program-Adult Treatment Panel-III (NCEP-ATPIII) definition being the most effective in the identification of glucose intolerance and cardiovascular risk. Except for these, MetS is associated with fatty liver disease, some forms of cancer, hypogonadism, and vascular dementia. The Mediterranean diet seems to be an ideal diet in patients with MetS, being rich in fibre, monounsaturated and polyunsaturated fats, and low in animal protein; and decreases the prevalence of MetS and cardiovascular disease risk. Except for weight loss, multifactorial intervention including insulin resistance reduction and normoglycemia, management of dyslipidemia, optimizing blood pressure and administration of low-dose aspirin for patients at high or moderately high cardiovascular disease (CVD) risk are additional targets. The present review provides current understanding about MetS in the Mediterranean region, focusing on its prevalence, clinical significance, and therapeutic strategy.

  11. Viewpoint on the current status of researches on sepsis

    Directory of Open Access Journals (Sweden)

    Zheng-guo WANG

    2012-11-01

    Full Text Available Sepsis is a common complication after severe trauma and burn, and also one of the main causes of death. Recently, although some new progresses were seen in antibiotic therapy, the mortality of sepsis is still on the rise, and the death rate as a result of sepsis is higher than a total of that of prostate cancer, breast cancer and AIDS. Therefore, sepsis has obviously become one of the serious ailments threatening human health. The present paper introduced the international definition of sepsis, severe sepsis and septic shock, the current researches on diagnosis and therapy, and proposed that we should not only pay attention to pathogenesis and treatment, but also to sepsis prevention in sepsis researches, and we should try to find out the breakthrough in the interaction and dynamic balance between human being and pathogenic factors. Researches on the strategies to revert strong toxicity of infectious agents to non-toxic or weak pathogenic factors, and to conduct further research concerning biological characteristics of microorganisms and mechanism of drug resistance in order to render them to lose the drug resistance ability, or to increase its sensitivity to the drugs. The above suggested approaches might form the future strategies for preventing and controlling sepsis.

  12. The current status of orphan drug development in Europe and the US.

    Science.gov (United States)

    Hall, Anthony K; Carlson, Marilyn R

    2014-02-01

    Orphan drug legislation has been introduced in a number of countries in order to stimulate the development of treatments for rare diseases by introducing commercial incentives for companies wishing to undertake that development. In order to navigate the maze of regulatory regulations and procedures so that companies can make proper use of the orphan drug incentives, specialist knowledge is required. This article will review the current status of orphan drug development in the EU and the US, explain the incentives and procedures, and touch on the role of patient organisations in the process.

  13. Evaluation and Management of Hepatic Encephalopathy: Current Status and Future Directions

    Science.gov (United States)

    Suraweera, Duminda; Sundaram, Vinay; Saab, Sammy

    2016-01-01

    Hepatic encephalopathy is a spectrum of neurocognitive manifestations often seen in patients with liver injury or rarely in patients with portosystemic shunting without liver injury. It can be divided into minimal (covert) hepatic encephalopathy and overt hepatic encephalopathy, depending on the severity. Patients with hepatic encephalopathy have compromised clinical outcomes, decreased quality of life, and increased healthcare utilization, often resulting in a heavy financial and personal burden on caregivers. The diagnosis remains largely clinical, with the exclusion of possible other causes for the altered mental status. Current treatment strategies include nonabsorbable disaccharides and antibiotics. This review will focus on the diagnosis, management and clinical impact of hepatic encephalopathy. PMID:27377741

  14. Online-coupled meteorology and chemistry models: history, current status, and outlook

    Directory of Open Access Journals (Sweden)

    Y. Zhang

    2008-06-01

    Full Text Available The climate-chemistry-aerosol-cloud-radiation feedbacks are important processes occurring in the atmosphere. Accurately simulating those feedbacks requires fully-coupled meteorology, climate, and chemistry models and presents significant challenges in terms of both scientific understanding and computational demand. This paper reviews the history and current status of the development and application of online-coupled meteorology and chemistry models, with a focus on five representative models developed in the US including GATOR-GCMOM, WRF/Chem, CAM3, MIRAGE, and Caltech unified GCM. These models represent the current status and/or the state-of-the science treatments of online-coupled models worldwide. Their major model features, typical applications, and physical/chemical treatments are compared with a focus on model treatments of aerosol and cloud microphysics and aerosol-cloud interactions. Aerosol feedbacks to planetary boundary layer meteorology and aerosol indirect effects are illustrated with case studies for some of these models. Future research needs for model development, improvement, application, as well as major challenges for online-coupled models are discussed.

  15. Weight status and body image perceptions in adolescents: current perspectives.

    Science.gov (United States)

    Voelker, Dana K; Reel, Justine J; Greenleaf, Christy

    2015-01-01

    Adolescence represents a pivotal stage in the development of positive or negative body image. Many influences exist during the teen years including transitions (eg, puberty) that affect one's body shape, weight status, and appearance. Weight status exists along a spectrum between being obese (ie, where one's body weight is in the 95th percentile for age and gender) to being underweight. Salient influences on body image include the media, which can target adolescents, and peers who help shape beliefs about the perceived body ideal. Internalization of and pressures to conform to these socially prescribed body ideals help to explain associations between weight status and body image. The concepts of fat talk and weight-related bullying during adolescence greatly contribute to an overemphasis on body weight and appearance as well as the development of negative body perceptions and dissatisfaction surrounding specific body parts. This article provides an overview of the significance of adolescent development in shaping body image, the relationship between body image and adolescent weight status, and the consequences of having a negative body image during adolescence (ie, disordered eating, eating disorders, and dysfunctional exercise). Practical implications for promoting a healthy weight status and positive body image among adolescents will be discussed.

  16. Low-dose antibiotics: current status and outlook for the future

    DEFF Research Database (Denmark)

    Antimicrobial therapy is a key factor in our success against pathogens poised to ravage at risk or infected individuals. However, we are currently at a watershed point as we face a growing crisis of antibiotic resistance among diverse pathogens. One area of intense interest is the impact of the a......Antimicrobial therapy is a key factor in our success against pathogens poised to ravage at risk or infected individuals. However, we are currently at a watershed point as we face a growing crisis of antibiotic resistance among diverse pathogens. One area of intense interest is the impact...... of the application of antibiotics for uses other than the treatment of patients and the association with such utilization with emerging drug resistance. This Research Topic “Low- dose antibiotics: current status and outlook for the future” in Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy...

  17. Current status of managing food allergies in schools in Seoul, Korea.

    Science.gov (United States)

    Kim, Soyoung; Yoon, Jihyun; Kwon, Sooyoun; Kim, Jihyun; Han, Youngshin

    2012-12-01

    Recently the need to manage food allergies in schools has been growing. This study aimed to examine the current status of managing food allergies in schools in Seoul, Korea. A questionnaire survey was conducted in cooperation with the School Dietician Association during April 2009. Among the participating 154 schools, a total of 109 (71%) were determining students' food allergy status through parental surveys based on self-reported food allergies. A total of 72 (47%) had experienced student visits to a school health room due to food allergies within one year before the survey. Over 80 percent of the schools relied on self-care only without any school-wide measures for food allergies in place. Among the 890 menu items most frequently served in school lunch programs, a total of 664 (75%) were found to contain more than one food allergen. It is highly suggested that preventive plans and treatment measures should be established to manage food allergies in schools.

  18. Lower hybrid current drive for edge current density modification in DIII-D: Final status report

    International Nuclear Information System (INIS)

    Fenstermacher, M.E.; Porkolab, M.

    1993-01-01

    Application of Lower Hybrid (LH) Current Drive (CD) in the DIII-D tokamak has been studied at LLNL, off and on, for several years. The latest effort began in February 1992 in response to a letter from ASDEX indicating that the 2.45 GHz, 3 MW system there was available to be used on another device. An initial assessment of the possible uses for such a system on DIII-D was made and documented in September 1992. Multiple meetings with GA personnel and members of the LH community nationwide have occurred since that time. The work continued through the submission of the 1995 Field Work Proposals in March 1993 and was then put on hold due to budget limitations. The purpose of this document is to record the status of the work in such a way that it could fairly easily be restarted at a future date. This document will take the form of a collection of Appendices giving both background and the latest results from the FY 1993 work, connected by brief descriptive text. Section 2 will describe the final workshop on LHCD in DIII-D held at GA in February 1993. This was an open meeting with attendees from GA, LLNL, MIT and PPPL. Summary documents from the meeting and subsequent papers describing the results will be included in Appendices. Section 3 will describe the status of work on the use of low frequency (2.45 GHZ) LH power and Parametric Decay Instabilities (PDI) for the special case of high dielectric in the edge regions of the DIII-D plasma. This was one of the critical issues identified at the workshop. Other potential issues for LHCD in the DIII-D scenarios are: (1) damping of the waves on fast ions from neutral beam injection, (2) runaway electrons in the low density edge plasma, (3) the validity of the WKB approximation used in the ray-tracing models in the steep edge density gradients

  19. The Current Status of the Economic Security of Poltava Region

    Directory of Open Access Journals (Sweden)

    Bondarevska Olha M.

    2017-12-01

    Full Text Available The status of economic security of Poltava region in 2012–2016 was analyzed, the analysis was conducted using the developed methodology for assessing economic security of region, which is based on the joint use of indicative and functional methods. In order to assess the status of economic security of region, a system of indicators, divided by economic security components, has been formed using functional approach. The information-analytical provision of assessment has been formed using statistical information on the socio-economic development of the region. The influence of factors of destabilizing and destimulative nature on the status of economic security of the region has been researched. It has been concluded that the economic security of Poltava region is unsatisfactory, despite the existence of some positive tendencies, which at present are not sustainable.

  20. Current status of Russian Evaluated Neutron Data Libraries

    International Nuclear Information System (INIS)

    Blokhin, A.I.; Ignatyuk, A.V.; Manokhin, V.N.; Nikolaev, M.N.

    1996-01-01

    The status of Russian Evaluated Data Libraries is discussed. The last modifications of the BROND-2 files and their relations to the additional files of the FOND library and the ABBN-90 group constants are considered. The main characteristics of new libraries for the photoneutron data, dosimetry and activation reaction cross sections and transmutation cross sections for intermediate energies are described briefly. (author)

  1. Current status of CHESS - the Cornell High Energy Synchrotron Source

    International Nuclear Information System (INIS)

    Mills, D.; Cornell Univ., Ithaca, NY

    1982-01-01

    This paper reviews the status of CHESS through its three-year construction period, which ends in the fall of 1981. Included are a brief description of beam lines, monochromators, station instrumentations and support facilities. Our experiences with source size and stability over the last year are reported, along with planned fall revisions and running schedule. (orig.)

  2. Current status of the EPR method to detect irradiated food

    International Nuclear Information System (INIS)

    Desrosiers, M.F.

    1996-01-01

    This review gives a brief outline of the principles of the EPR detection method for irradiated foods by food type. For each food type, the scope, limitations and status of the method are given. The extensive reference list aims to include all which define the method, as well as some rarely cited works of historical importance. (author)

  3. ACRF Instrumentation Status: New, Current, and Future January 2007

    Energy Technology Data Exchange (ETDEWEB)

    Liljegren, JC

    2007-01-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Program Climate Research Facility instrumentation status. The report is divided into four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development.

  4. ACRF Instrumentation Status: New, Current, and Future October 2006

    Energy Technology Data Exchange (ETDEWEB)

    JC Liljegren

    2006-10-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Program Climate Research Facility instrumentation status. The report is divided into four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development.

  5. ACRF Instrumentation Status: New, Current, and Future May 2007

    Energy Technology Data Exchange (ETDEWEB)

    JC Liljegren

    2007-05-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Program Climate Research Facility instrumentation status. The report is divided into four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development.

  6. ACRF Instrumentation Status: New, Current, and Future February 2007

    Energy Technology Data Exchange (ETDEWEB)

    JC Liljegren

    2007-02-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Program Climate Research Facility instrumentation status. The report is divided into four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development

  7. ACRF Instrumentation Status: New, Current, and Future May 2007

    Energy Technology Data Exchange (ETDEWEB)

    JC Liljegren

    2007-04-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Program Climate Research Facility instrumentation status. The report is divided into four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development.

  8. ACRF Instrumentation Status: New, Current, and Future March 2007

    Energy Technology Data Exchange (ETDEWEB)

    JC Liljegren

    2007-03-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Program Climate Research Facility instrumentation status. The report is divided into four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development.

  9. ACRF Instrumentation Status: New, Current, and Future - February 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-03-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development.

  10. ACRF Instrumentation Status: New, Current, and Future - March 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-04-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development.

  11. The current treatment of erectile dysfunction

    Directory of Open Access Journals (Sweden)

    Maria Isabela Sarbu

    2016-10-01

    Full Text Available Erectile dysfunction (ED is the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. It is the most frequent sexual dysfunction in elderly men and its prevalence increases with age. Ever since ED was recognized as a real health problem, several treatment options became available and some of them proved to be very efficient. PDE5 inhibitors are the mainstay treatment of ED. However, other treatment options such as intracorporal injections, surgery, vacuum devices and prosthesis are also available for patients who are unresponsive to PDE5 inhibitors. Since none of the treatment options available so far has proven ideal, research in the field of sexual medicine continues. The aim of this paper is to review the most advances in the treatment of ED.

  12. Weight status and body image perceptions in adolescents: current perspectives

    Directory of Open Access Journals (Sweden)

    Voelker DK

    2015-08-01

    Full Text Available Dana K Voelker,1 Justine J Reel,2 Christy Greenleaf3 1West Virginia University, College of Physical Activity and Sport Sciences, Morgantown, WV, 2University of North Carolina Wilmington, College of Health and Human Services, Wilmington, NC, 3University of Wisconsin–Milwaukee, College of Health Sciences, Milwaukee, WI, USA Abstract: Adolescence represents a pivotal stage in the development of positive or negative body image. Many influences exist during the teen years including transitions (eg, puberty that affect one’s body shape, weight status, and appearance. Weight status exists along a spectrum between being obese (ie, where one’s body weight is in the 95th percentile for age and gender to being underweight. Salient influences on body image include the media, which can target adolescents, and peers who help shape beliefs about the perceived body ideal. Internalization of and pressures to conform to these socially prescribed body ideals help to explain associations between weight status and body image. The concepts of fat talk and weight-related bullying during adolescence greatly contribute to an overemphasis on body weight and appearance as well as the development of negative body perceptions and dissatisfaction surrounding specific body parts. This article provides an overview of the significance of adolescent development in shaping body image, the relationship between body image and adolescent weight status, and the consequences of having a negative body image during adolescence (ie, disordered eating, eating disorders, and dysfunctional exercise. Practical implications for promoting a healthy weight status and positive body image among adolescents will be discussed. Keywords: adolescence, eating disorders, obesity, bullying, puberty, physical activity

  13. Poisoining with Tricyclic Antidepressants and Current Treatment

    Directory of Open Access Journals (Sweden)

    Muge Gulen

    2016-12-01

    Full Text Available Poisoning with tricyclic antidepressants is one of the main causes of morbidity and mortality compared to all the antidepressants. Main toxic effects are on the cardiovascular system and central nervous system and manifests itself as anticholinergic symptoms. There is no antidote known to be used in the treatment. But sodium bicarbonate treatment is effective in preventing ventricular arrhythmias and hypotension, and resolving metabolic acidosis. There are some treatments that has been used for relief of symptoms and some of them still are in research stage. The drugs that are used can be customized according to the patients symptoms. [Archives Medical Review Journal 2016; 25(4.000: 608-621

  14. Infectious pleural effusion status and treatment progress

    Science.gov (United States)

    Yang, Wei; Zhang, Ze-Ming

    2017-01-01

    Pleural cavity infection continuously seriously threatens human health with continuous medical progress. From the perspective of pathophysiology, it can be divided into three stages: exudative stage, fibrin exudation and pus formation stage, and organization stage. Due to the pathogenic bacteria difference of pleural cavity infection and pulmonary infection, it is very important for disease treatment to analyze the bacteria and biochemical characteristics of the infectious pleural effusion. Most prognoses of patients have been relatively good, while for some patients, the complicated parapneumonic effusion or empyema could be evolved. Antibiotic treatment and sufficient drainage are the foundation for this treatment. No evidence can support the routine use of a fibrin agent. However, it has been reported that the plasminogen activator and deoxyribonuclease can be recommended to be applied in the pleural cavity. In case of failure on conservative medical treatment, operative treatment can be applied such as thoracoscopy and pleural decortication. According to the clinical characteristics of these patients, it is a key to research prognosis, as well as early evaluation and stratification, in the future. PMID:29268539

  15. Current treatment approach of bone metastases

    International Nuclear Information System (INIS)

    Gómez Cabrera, Erasmo Pablo

    2016-01-01

    The document deals with the cancer situation in Cuba; the factors that produce and causes destruction of bone metastases. It also describes osteoblastic and osteolytic lesions; and details the different treatments for bone metastases

  16. Neoadjuvant Treatment in Rectal Cancer: Actual Status

    Science.gov (United States)

    Garajová, Ingrid; Di Girolamo, Stefania; de Rosa, Francesco; Corbelli, Jody; Agostini, Valentina; Biasco, Guido; Brandi, Giovanni

    2011-01-01

    Neoadjuvant (preoperative) concomitant chemoradiotherapy (CRT) has become a standard treatment of locally advanced rectal adenocarcinomas. The clinical stages II (cT3-4, N0, M0) and III (cT1-4, N+, M0) according to International Union Against Cancer (IUCC) are concerned. It can reduce tumor volume and subsequently lead to an increase in complete resections (R0 resections), shows less toxicity, and improves local control rate. The aim of this review is to summarize actual approaches, main problems, and discrepancies in the treatment of locally advanced rectal adenocarcinomas. PMID:22295206

  17. Rice Genome Research: Current Status and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Bin Han

    2008-11-01

    Full Text Available Rice ( L. is the leading genomics system among the crop plants. The sequence of the rice genome, the first cereal plant genome, was published in 2005. This review summarizes progress made in rice genome annotations, comparative genomics, and functional genomics researches. It also maps out the status of rice genomics globally and provides a vision of future research directions and resource building.

  18. ACRF Instrumentation Status: New, Current, and Future July 2006

    Energy Technology Data Exchange (ETDEWEB)

    JC Liljegren

    2006-07-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Program Climate Research Facility instrumentation status. The report is divided into four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development. New information is highlighted in blue text.

  19. ACRF Instrumentation Status: New, Current, and Future September 2006

    Energy Technology Data Exchange (ETDEWEB)

    JC Liljegren

    2006-09-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Program Climate Research Facility instrumentation status. The report is divided into four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development. New information is highlighted in blue text.

  20. ACRF Instrumentation Status: New, Current, and Future August 2006

    Energy Technology Data Exchange (ETDEWEB)

    JC Liljegren

    2006-08-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Program Climate Research Facility instrumentation status. The report is divided into four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) Small Business Innovation Research instrument development. New information is highlighted in blue text.

  1. Safety analysis reports. Current status (third key report)

    International Nuclear Information System (INIS)

    1999-01-01

    A review of Ukrainian regulations and laws concerned with Nuclear power and radiation safety is presented with an overview of the requirements for the Safety Analysis Report Contents. Status of Safety Analysis Reports (SAR) is listed for each particular Ukrainian NPP including SAR development schedules. Organisational scheme of SAR development works includes: general technical co-ordination on Safety Analysis Report development; list of leading organisations and utilization of technical support within international projects

  2. Current Status & Development Trend of VSAT Market in China

    Institute of Scientific and Technical Information of China (English)

    Xu Nutu

    2006-01-01

    @@ 1. General Status of VSAT Market Development in China 1)Development History Development in China The history of the application of satellite communication in China is not too long and it was dated from the early seventies of the 20th century. In 1973, approved by Chinese government,Ministry of Posts and Telecommunications purchased satellite earth equipment from foreign country and constructed 3 stations in Shanghai and Beijing.

  3. Current status of the near surface repository in Romania

    International Nuclear Information System (INIS)

    Andrei, V.; Glodeanu, F.; Rotaru, I.

    2000-01-01

    The radioactive waste management at the Cernavoda NPP is based on collection, pretreatment and storage of all solid wastes. The disposal of operational and decommissioning wastes has been evaluated, based on the results of a research and development programme. A near surface disposal facility was selected and a siting process was implemented. The status of this project and its prospective are discussed in the paper. (author)

  4. ACRF Instrumentation Status: New, Current, and Future - April 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-05-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  5. ACRF Instrumentation Status: New, Current, and Future - December 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2009-01-15

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  6. ACRF Instrumentation Status: New, Current, and Future February 2009

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2009-02-15

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  7. ACRF Instrumentation Status: New, Current, and Future - September 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-10-15

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  8. ACRF Instrumentation Status: New, Current, and Future - July 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-07-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  9. ACRF Instrumentation Status: New, Current, and Future - August 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-09-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  10. ACRF Instrumentation Status: New, Current, and Future - June 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-07-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  11. ACRF Instrumentation Status: New, Current, and Future - October 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-10-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  12. ACRF Instrumentation Status: New, Current, and Future March 2009

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2009-03-15

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  13. ACRF Instrumentation Status: New, Current, and Future - May 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-05-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  14. ACRF Instrumentation Status: New, Current, and Future - January 2009

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2009-03-02

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  15. ACRF Instrumentation Status: New, Current, and Future - November 2008

    Energy Technology Data Exchange (ETDEWEB)

    JW Voyles

    2008-12-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  16. Current status of Chinese nuclear power industry and technology

    International Nuclear Information System (INIS)

    Kim, Hyun Min; Kim, Min; Jeong, Hee Jong; Hwang, Jeong Ki; Cho, Chung Hee

    1996-10-01

    China has been carrying out active international cooperation aiming to be a country where is to be an economical super power and an advanced country in nuclear power technology by the year early 2000, and China also has begun to be recognized as the largest potential market for the construction of nuclear power plants(NPPs) expecting to construct more than thirty nuclear power units by the year 2020. China has advanced technology in the basic nuclear science including liquid metal breeder reactor technology, nuclear material, medium and small size power plants, and isotope production technology, and also China has complete nuclear fuel cycle technology. However, China still has low NPP technology. Therefore, it is expected that China may have complementary cooperative relationship with China, it is expected that Korea may have an access to the advanced Chinese nuclear science technology, and may have a good opportunity to explore the Chinese market actively exporting excellent Korean NPP technology, and further may have a good position to the neighboring Asian countries' NPP markets. From this perspective, general Chinese social status, major nuclear R and D activity status, and correct NPP and technology status have been analyzed in this report, and this report is expected to be a useful resource for cooperating with China in future. 10 tabs., 6 figs., 16 refs. (Author)

  17. New horizons in predictive toxicology: current status and application

    National Research Council Canada - National Science Library

    Wilson, A. G. E

    2012-01-01

    "In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments...

  18. The current implementation status of the integration of sports and physical activity into Dutch rehabilitation care.

    Science.gov (United States)

    Hoekstra, Femke; Hettinga, Florentina J; Alingh, Rolinde A; Duijf, Marjo; Dekker, Rienk; van der Woude, Lucas H V; van der Schans, Cees P

    2017-01-01

    To describe the current status of the nationwide implementation process of a sports and physical activity stimulation programme to gain insight into how sports and physical activity were integrated into Dutch rehabilitation care. The current implementation status of a sports and physical activity stimulation programme in 12 rehabilitation centres and 5 hospitals with a rehabilitation department was described by scoring fidelity and satisfaction. Seventy-one rehabilitation professionals filled out a questionnaire on how sports and physical activity, including stimulation activities, were implemented into rehabilitation care. Total fidelity scores (in %) were calculated for each organization. Professionals' satisfaction was rated on a scale from 1 to 10. In most organizations sports and physical activity were to some extent integrated during and after rehabilitation (fidelity scores: median = 54%, IQR = 23%). Physical activity stimulation was not always embedded as standard component of a rehabilitation treatment. Professionals' satisfaction rated a median value of 8.0 (IQR = 0.0) indicating high satisfaction rates. The fidelity outcome showed that activities to stimulate sports and physical activity during and after rehabilitation were integrated into rehabilitation care, but not always delivered as standardized component. These findings have emphasized the importance to focus on integrating these activities into routines of organizations. Implications for Rehabilitation Components of an evidence-based programme to stimulate sports and physical activity during and after rehabilitation can be used to measure the current status of the integration of sports and physical activity in rehabilitation care in a structural and effective way. The method described in the current study can be used to compare the content of the rehabilitation care regarding the integration of sports and physical activity among organizations both on a national and international level

  19. Female pattern hair loss: Current treatment concepts

    Directory of Open Access Journals (Sweden)

    Quan Q Dinh

    2007-07-01

    Full Text Available Quan Q Dinh, Rodney SinclairDepartment of Dermatology, St Vincent’s Hospital, Fitzroy, Victoria, AustraliaAbstract: Fewer than 45% of women go through life with a full head of hair. Female pattern hair loss is the commonest cause of hair loss in women and prevalence increases with advancing age. Affected women may experience psychological distress and impaired social functioning. In most cases the diagnosis can be made clinically and the condition treated medically. While many women using oral antiandrogens and topical minoxidil will regrow some hair, early diagnosis and initiation of treatment is desirable as these treatments are more effective at arresting progression of hair loss than stimulating regrowth. Adjunctive nonpharmacological treatment modalities such as counseling, cosmetic camouflage and hair transplantation are important measures for some patients. The histology of female pattern hair loss is identical to that of male androgenetic alopecia. While the clinical pattern of the hair loss differs between men, the response to oral antiandrogens suggests that female pattern hair loss is an androgen dependant condition, at least in the majority of cases. Female pattern hair loss is a chronic progressive condition. All treatments need to be continued to maintain the effect. An initial therapeutic response often takes 12 or even 24 months. Given this delay, monitoring for treatment effect through clinical photography or standardized clinical severity scales is helpful.Keywords: female pattern hair loss, androgenetic alopecia

  20. Gender and offender status predicting treatment success in refugees and asylum seekers with PTSD

    Directory of Open Access Journals (Sweden)

    Håkon Stenmark

    2014-01-01

    Full Text Available Background: Current knowledge is limited regarding patient characteristics related to treatment outcome of posttraumatic stress disorders (PTSD in refugees and asylum seekers. Objective: Gender, torture status, offender status, level of anger, and level of depression were investigated for possible effects on the treatment outcome. Method: Patient characteristics were explored in 54 refugees and asylum seekers who had completed a treatment program for PTSD. Non-responders (10, those who had the same or higher levels of symptom severity after treatment, were compared with responders, those who had lower symptom severity after treatment (44. Symptom severity was measured by Clinician-Administered PTSD Scale. The non-responders and responders constituted the dichotomous, dependent variable. The independent variables were gender, torture status, offender status, level of anger, and level of depression. T-tests and Exact Unconditional Homogeneity/Independence Tests for 2X2 Tables were used to study the relationship to treatment outcome. Results: Being male and reporting to have been a violent offender were significantly more frequent characteristics among the non-responders compared to the responders. The levels of pretreatment anger, depression and torture status did not affect the treatment outcome. Conclusions: The study adds support to findings that females benefit more from treatment of PTSD than males and that violent offenders are difficult to treat within the standard treatment programs.

  1. Tele-yoga for Chronic Pain: Current Status and Future Directions.

    Science.gov (United States)

    Mathersul, Danielle C; Mahoney, Louise A; Bayley, Peter J

    2018-01-01

    Pain is a pervasive, debilitating disorder that is resistant to long-term pharmacological interventions. Although psychological therapies such as cognitive behavior therapy demonstrate moderate efficacy, many individuals continue to have ongoing difficulties following treatment. There is a current trend to establish complementary and integrative health interventions for chronic pain, for which yoga has been found to have exciting potential. Nevertheless, an important consideration within the field is accessibility to adequate care. Telehealth can be used to provide real-time interactive video conferencing leading to increased access to health care for individuals located remotely or who otherwise have difficulty accessing services, perhaps through issues of mobility or proximity of adequate services. This article assesses the current status and feasibility of implementing tele-yoga for chronic pain. Methodological limitations and recommendations for future research are discussed.

  2. Current and future treatment options for acne.

    NARCIS (Netherlands)

    Kerkhof, P.C.M. van de; Kleinpenning, M.M.; Jong, E.M.G.J. de; Gerritsen, M.J.P.; Dooren-Greebe, R.J. van; Alkemade, J.A.C.

    2006-01-01

    Acne is a frequent skin disease with abnormalities in the process of keratinization, sebaceous gland functioning and inflammation. In this review, our understanding of the pathogenesis of acne has been updated. An overview of efficacy and side effects of available anti-acne treatments is presented.

  3. Current Directions in ADHD and Its Treatment

    Science.gov (United States)

    Norvilitis, Jill M., Ed.

    2012-01-01

    The treatment of Attention Deficit Hyperactivity Disorder is a matter of ongoing research and debate, with considerable data supporting both psychopharmacological and behavioral approaches. Researchers continue to search for new interventions to be used in conjunction with or in place of the more traditional approaches. These interventions run the…

  4. Current perspectives on the treatment of ADHD

    Directory of Open Access Journals (Sweden)

    Eduardo Chaves Cruz

    2010-06-01

    Full Text Available Three short-term interventions have been corroborated for the treatment of ADHD (Attention Deficit Hyperactivity Disorder: psychotherapeutic (behavioural, psychopharmacological, and the combining of both interventions. This article reviews clinical questions, limitations and efficacy of these interventions. Behavioural interventions in the form of Parental Behavioural Training and the Management of Behavioural Contingencies in the Classroom seem to be particularly efficacious.

  5. [Current Status and Challenges of CAR-T Immunotherapy in Hematologic Malignancies -Review].

    Science.gov (United States)

    Cheng, Xin; Wang, Ya-Jie; Feng, Shuai; Wu, Ya-Yun; Yang, Tong-Hua; Lai, Xun

    2018-04-01

    The chimeric antigen receptor (CAR) T cell therapy has gradually became a new trend in the treatment of refractory and relapsed hematologic malignancies by developing for 30 years. With the exciting development of genetic engineering, CAR-T technology has subjected to 4 generations of innovation. Structure of CAR-T started from a single signal molecule to 2 or more than 2 co-stimulatory molecules, and then coding the CAR gene or promoter. CAR-T can specifically recognize tumor antigens, and does not be restricted by major histocompatibility complex (MHC), thus making a breakthrough in clinical treatment. In this review, the history, structure and mechanism of action of CAR-T, as well as the current status and challenges of CAR-T immunotherapy in acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia and multiple myeloma are summarized.

  6. The current implementation status of the integration of sports and physical activity into Dutch rehabilitation care

    NARCIS (Netherlands)

    Hoekstra, Femke; Hettinga, Florentina J; Alingh, Rolinde A; Duijf, Marjo; Dekker, Rienk; van der Woude, Lucas H V; van der Schans, Cees P

    PURPOSE: To describe the current status of the nationwide implementation process of a sports and physical activity stimulation programme to gain insight into how sports and physical activity were integrated into Dutch rehabilitation care. METHODS: The current implementation status of a sports and

  7. The proton ''spin contents'': Current status ampersand perspectives

    International Nuclear Information System (INIS)

    Cheng, Ta-Pei; Li, Ling-Fong

    1990-01-01

    The present status of the phenomenological and theoretical interpretation of the EMC result on the polarized deep elastic scattering is reviewed. We focus our discussion on the possibility of a significant gluonic contribution to the proton spin via the axial anomaly. We contrast the variant perspectives on this question: the viewpoint that stresses the interpretation in terms of the parton distributions vs the one that concentrates on the matrix elements of local operators. Some remarks concerning the validity of OZI rule for the strange quark are also included. 53 refs

  8. Current Status and Challenges in Wind Energy Assessment

    DEFF Research Database (Denmark)

    Gryning, Sven-Erik; Badger, Jake; Hahmann, Andrea N.

    2014-01-01

    Here we discuss the status and challenges in the development of atlases for the assessment of the regional and global wind resources. The text more specifically describes a methodology that is under development at DTU Wind Energy in Denmark. As the wind assessment is based on mesoscale modelling,......, some of the specific challenges in mesoscale modelling for wind energy purposes are discussed such as wind profiles and long-term statistics of the wind speed time series. Solutions to these challenges will help secure an economic and effective deployment of wind energy....

  9. Current Status and Outlook in the Application of Microalgae in Biodiesel Production and Environmental Protection

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xin [Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan (China); University of Chinese Academy of Sciences, Beijing (China); Rong, Junfeng [SINOPEC Research Institute of Petroleum Processing, Beijing (China); Chen, Hui; He, Chenliu; Wang, Qiang, E-mail: wangqiang@ihb.ac.cn [Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan (China)

    2014-08-19

    Microalgae have been currently recognized as a group of the most potential feedstocks for biodiesel production due to high productivity potential, efficient biosynthesis of lipids, and less competition with food production. Moreover, utilization of microalgae with environmental purposes (CO{sub 2} fixation, NO{sub x}, and wastewater treatment) and biorefinery has been reported. However, there are still challenges that need to be addressed to ensure stable large-scale production with positive net energy balance. This review gives an overview of the current status of the application of microalgae in biodiesel production and environmental protection. The practical problems not only facing the microalgae biodiesel production but also associated with microalgae application for environmental pollution control, in particular biological fixation of greenhouse gas (CO{sub 2} and NO{sub x}) and wastewater treatment are described in detail. Notably, the synergistic combination of various applications (e.g., food, medicine, wastewater treatment, and flue gas treatment) with biodiesel production could enhance the sustainability and economics of the algal biodiesel production system.

  10. Current status and outlook in the application of microalgae in biodiesel production and environmental protection

    Directory of Open Access Journals (Sweden)

    Xin eZhang

    2014-08-01

    Full Text Available Microalgae have been currently recognized as one group of the most potential feedstocks for biodiesel production due to high productivity potential, efficient biosynthesis of lipids and less competition with food production. Moreover, utilization of microalgae with environmental purposes (CO2 fixation, NOX and wastewater treatment and biorefinery have been reported. However, there are still challenges that need to be addressed to ensure stable large-scale production with positive net energy balance. This review gives an overview of the current status of the application of microalgae in biodiesel production and environmental protection. The practical problems not only facing the microalgae biodiesel production but also associated with microalgae application for environmental pollution control, in particular biological fixation of greenhouse gas (CO2 and NOX and wastewater treatment are described in detail. Notably, the synergistic combination of various applications (e.g. food, medicine, wastewater treatment and flue gas treatment with biodiesel production could enhance the sustainability and economics of the algal biodiesel production system.

  11. Prolactinoma treatment status in the cabergoline era

    International Nuclear Information System (INIS)

    Watanabe, Shinya; Takano, Shingo; Akutsu, Hiroyoshi; Sato, Hiroshige; Matsumura, Akira

    2011-01-01

    The aim of our study is to report the most adequate therapy for prolactinoma in the cabergoline era. From 2003 to 2009, 27 patients with prolactinoma were treated at our hospital. Patients are categorized into 2 groups. The Cabergoline Group: Cabergoline was administered for 5 years and discontinued. Using this protocol, the case with normal prolactin level in addition to having no visible tumor more than 24 months after the discontinuation of cabergoline was judged as cured. The Operation Group: Transsphenoidal surgery (TSS) was performed first. In the Cabergoline group, 12 cases were cured with 5 years cabergoline treatment (Cure) and 6 cases were not cured (Not cure). We compared the pretreatment prolactin level, the normalization of the serum level of prolactin, the degree of invasiveness on MRI, regression of the tumor during treatment on MRI, max dose of cabergoline, degree of pituitary hormone replacement, frequency of pregnancy, and follow up periods between the Cabergoline-cure group, the Cabergoline-not-cure group, and the Operation group. Normalization rate in serum level of prolactin and cure rate were 91% and 63% in the Cabergoline group. Pretreatment prolactine level and the frequency of tumor invasiveness on initial MRI were significantly higher in the Cabergoline-not-cure group compared to the Cabergoline-cure group. All of the five woman accompanied with pregnancy after the treatment belonged to the Cabergoline-cure group. In the Operation group, all 4 cases achieved normalization of serum prolactin level without visible tumor and with normal pituitary function. Cabergoline for prolactinoma is effective, but the cure rate by continuous usage of cabergoline for 5 years was 67%. The factors that cabergoline and/or TSS can cure prolactinoma are non-invasive tumor and prolactin level under 200 ng/mL at pretreatment. (author)

  12. The current status of radioactive monitoring gauges in UIC

    International Nuclear Information System (INIS)

    Ji Changsong

    1993-01-01

    The author introduces the characteristics of representative products for current environment radiation monitoring and measurement instruments of radiation nuclide content in UIC including aerosol detection equipment and multi function radiation dosemeters

  13. Medicinal Use of Cannabis: History and Current Status

    Directory of Open Access Journals (Sweden)

    Harold Kalant

    2001-01-01

    Full Text Available OBJECTIVE: To provide an overview of the history and pharmacology of cannabis in relation to current scientific knowledge concerning actual and potential therapeutic uses of cannabis preparations and pure cannabinoids.

  14. Biofuel implementation in East Europe: Current status and future prospects

    International Nuclear Information System (INIS)

    Kondili, E.M.; Kaldellis, J.K.

    2007-01-01

    There is a continuously increasing interest concerning the biofuel implementation in Europe, mainly because of environmental protection and energy supply security reasons. In this context, the European Union (EU) strongly encourages the use of biofuels through a number of Directives. To that effect, EU members follow the Directives implementing various political, fiscal and technical measures and incentives. In the light of the potential created by the recently joined Eastern European countries, an increasing interest is shown in the whole biofuel supply chain within the EU. In parallel, the status of the Eastern European countries domestic market, as far as biofuels are concerned, is an interesting issue, since most of these countries present a significant potential, however still lagging in biofuel implementation. In the above context, the objective of the present work is to give a concise and up-to-date picture of the present status of biofuel implementation in East Europe. The work also aims at identifying the prospects of these countries as far as biofuels are concerned and their role in the EU framework as potential suppliers of a wider market. (author)

  15. The current status of immunotherapy in peritoneal carcinomatosis.

    Science.gov (United States)

    Ströhlein, Michael Alfred; Heiss, Markus Maria; Jauch, Karl-Walter

    2016-10-01

    Peritoneal carcinomatosis (PC) is a cancer disease with an urgent need for effective treatment. Conventional chemotherapy failed to show acceptable results. Cytoreductive surgery and hyperthermic chemoperfusion (HIPEC) are only beneficial in few patients with resectable peritoneal metastasis. Immunotherapy could be attractive against PC, as all requirements for immunotherapy are available in the peritoneal cavity. This review analyzes the present literature for immunotherapy of PC. Advances from immune stimulators, radionucleotide-conjugated- and bispecific antibodies to future developments like adoptive engineered T-cells with chimeric receptors are discussed. The clinical development of catumaxomab, which was the first intraperitoneal immunotherapy to be approved for clinical treatment, is discussed. The requirements for future developments are illustrated. Expert commentary: Immunotherapy of peritoneal carcinomatosis is manageable, showing striking cancer cell killing. Improved profiles of adverse events by therapy-induced cytokine release, enhanced specific killing and optimal treatment schedules within multimodal treatment will be key factors.

  16. Current status of oncothermia therapy for lung cancer.

    Science.gov (United States)

    Szasz, Andras

    2014-04-01

    Lung cancer is one of the most common malignant tumors, and it has the highest death rate. Oncothermia is a feasible and successful treatment for lung cancer. Results show a remarkable survival benefit for patients, with a good quality of life. The treatment has no, or in some cases mild, side-effects and could decrease the adverse effects of the complementary treatment. Applying oncothermia together with other treatment methods could increase the effects and result in better performance. A comparison of studies demonstrates a good correspondence in the data, which strengthens the reliability of the studies, and clearly shows the feasibility of the application of oncothermia to treating all kinds of pulmonary malignancies including non-small-cell and small-cell primary tumors, and all of the metastatic diseases of the pulmonary system.

  17. Opiate addiction - current trends and treatment options

    OpenAIRE

    Achal Bhatt; Aminder Gill

    2016-01-01

    Opioids are widely used drugs for treatment of pain and related disorders. Opiate addiction is a major public health concern in the United States causing significant increase in healthcare expenditure. They produce euphoria and sense of well-being which makes them addictive to some people. Used in higher doses they can lead to cardiac or respiratory compromise. They also impair cognition leading to impaired decision making. Opioids exert their effects by acting on three different types of re...

  18. Standardized Treatment of Neonatal Status Epilepticus Improves Outcome.

    Science.gov (United States)

    Harris, Mandy L; Malloy, Katherine M; Lawson, Sheena N; Rose, Rebecca S; Buss, William F; Mietzsch, Ulrike

    2016-12-01

    We aimed to decrease practice variation in treatment of neonatal status epilepticus by implementing a standardized protocol. Our primary goal was to achieve 80% adherence to the algorithm within 12 months. Secondary outcome measures included serum phenobarbital concentrations, number of patients progressing from seizures to status epilepticus, and length of hospital stay. Data collection occurred for 6 months prior and 12 months following protocol implementation. Adherence of 80% within 12 months was partially achieved in patients diagnosed in our hospital; in pretreated patients, adherence was not achieved. Maximum phenobarbital concentrations were decreased (56.8 vs 41.0 µg/mL), fewer patients progressed from seizures to status epilepticus (46% vs 36%), and hospital length of stay decreased by 9.7 days in survivors. In conclusion, standardized, protocol-driven treatment of neonatal status epilepticus improves consistency and short-term outcome. © The Author(s) 2016.

  19. Status epilepticus in the elderly: epidemiology, clinical aspects and treatment

    Science.gov (United States)

    de Assis, Telma M.R.; Costa, Gersonita; Bacellar, Aroldo; Orsini, Marco; Nascimento, Osvaldo J.M.

    2012-01-01

    The aim of the study was to review the epidemiology, clinical profile and discuss the etiology, prognosis and treatment options in patients aged 60 years or older presenting with status epilepticus. We performed a systematic review involving studies published from 1996 to 2010, in Medline/PubMed, Scientific Electronic Library on line (Scielo), Latin-American and Caribbean Center of Health Sciences Information (Lilacs) databases and textbooks. Related articles published before 1996, when relevant for discussing epilepsy in older people, were also included. Several population studies had shown an increased incidence of status epilepticus after the age of 60 years. Status epilepticus is a medical and neurological emergency that is associated with high morbidity and mortality, and is a major concern in the elderly compared to the general population. Prompt diagnosis and effective treatment of convulsive status epilepticus are crucial to avoid brain injury and reduce the fatality rate in this age group. PMID:23355930

  20. Ketogenic diet treatment for pediatric super-refractory status epilepticus.

    Science.gov (United States)

    Appavu, Brian; Vanatta, Lisa; Condie, John; Kerrigan, John F; Jarrar, Randa

    2016-10-01

    We aimed to study whether ketogenic diet (KD) therapy leads to resolution of super-refractory status epilepticus in pediatric patients without significant harm. A retrospective review was performed at Phoenix Children's Hospital on patients with super-refractory status epilepticus undergoing ketogenic diet therapy from 2011 to 2015. Ten children with super-refractory status epilepticus, ages 2-16 years, were identified. 4/10 patients had immune mediated encephalitis, including Rasmussen encephalitis, anti-N-methyl-d-aspartate receptor encephalitis, and post-infectious mycoplasma encephalitis. Other etiologies included Lennox Gastaut Syndrome, non-ketotic hyperglycinemia, PCDH19 and GABRG2 genetic epilepsy, New Onset Refractory Status Epilepticus, and Febrile Infection-Related Epilepsy Syndrome. 4/10 patients' EEG features suggested focal with status epilepticus, and 6/10 suggested generalized with status epilepticus. Median hospital length was 61days and median ICU length was 27days. The median number of antiepileptic medications prior to diet initiation was 3.0 drugs, and the median after ketogenic diet treatment was 3.5 drugs. Median duration of status epilepticus prior to KD was 18days. 9/10 patients had resolution of super-refractory status epilepticus in a median of 7days after diet initiation. 8/9 patients were weaned off anesthesia within 15days of diet initiation, and within 1day of achieving ketonuria. 1/10 patients experienced side effects on the diet requiring supplementation. Most patients achieved resolution of status epilepticus on KD therapy, suggesting it could be an effective therapy that can be utilized early in the treatment of children with super refractory status epilepticus. Copyright © 2016. Published by Elsevier Ltd.