WorldWideScience

Sample records for current study included

  1. Micromagnetic model for studies on Magnetic Tunnel Junction switching dynamics, including local current density

    Energy Technology Data Exchange (ETDEWEB)

    Frankowski, Marek, E-mail: mfrankow@agh.edu.pl; Czapkiewicz, Maciej; Skowronski, Witold; Stobiecki, Tomasz

    2014-02-15

    We present a model introducing the Landau–Lifshitz–Gilbert equation with a Slonczewski's Spin-Transfer-Torque (STT) component in order to take into account spin polarized current influence on the magnetization dynamics, which was developed as an Object Oriented MicroMagnetic Framework extension. We implement the following computations: magnetoresistance of vertical channels is calculated from the local spin arrangement, local current density is used to calculate the in-plane and perpendicular STT components as well as the Oersted field, which is caused by the vertical current flow. The model allows for an analysis of all listed components separately, therefore, the contribution of each physical phenomenon in dynamic behavior of Magnetic Tunnel Junction (MTJ) magnetization is discussed. The simulated switching voltage is compared with the experimental data measured in MTJ nanopillars.

  2. An induction machine model including interbar currents for studying performances during transients and steady state

    Energy Technology Data Exchange (ETDEWEB)

    Razik, H. [Universite Henri Poincare, GREEN, CNRS-UMR 7037, BP 239, F-54506 Vandoeuvre-les-Nancy Cedex (France); Henao, H. [University of Picardie, CREA, 33 rue Saint Leu, F-80039 Amiens Cedex 1 (France); Carlson, R. [GRUCAD/CTC/UFSC, Campus Universitario, C.P. 436, Florianopolis - SC, 88040-900 (Brazil)

    2009-01-15

    This paper presents a mathematical model of a three-phase induction motor taking into consideration the interbar contacts. Several models have been available in the references. However, they consider the rotor of the induction motor as being constituted either a three-phase or a squirrel cage even if it operates under stator and/or rotor faults condition. Nonetheless, the contact between a bar and the iron core for the machine has to be considered, especially when a rotor fault occurs. It is obvious that rotor currents are under the influence of rotor constitution materials. So, the paper aim's concerns a transient model of the induction motors which can consider the rotor broken bars defect. Despite its increasing complexity, it could be able to provide with useful indications for diagnostic purposes. This model is advocated for the simulation of motors behavior under rotor defect which takes into account the interbar currents. The proposed technique is based on the mesh model analysis of the squirrel cage. As low power induction motors are prevalent in industrial plants, we pay a special attention on them. Notwithstanding, additional currents are due to the contact between the non-insulated bar constituting the squirrel cage to the rotor iron core. The monitoring of induction motors is predominantly made through the stator current analysis of the motor when it operates at nominal condition. Moreover, this one is observed in steady state operating system, knowing that the motor is generally fed by a sinusoidal supply. Consequently, simulation results showed in this paper prove the effectiveness of the proposed approach, and the impact of interbar resistance both on the model and the line current spectrum for the diagnostic. An experimental test proves the effectiveness of this model. (author)

  3. Study Modules for Calculus-Based General Physics. [Includes Modules 27-30: Direct-Current Circuits; Magnetic Forces; Ampere's Law; and Faraday's Law].

    Science.gov (United States)

    Fuller, Robert G., Ed.; And Others

    This is part of a series of 42 Calculus Based Physics (CBP) modules totaling about 1,000 pages. The modules indlude study guides, practice tests, and mastery tests for a full-year individualized course in calculus-based physics based on the Personalized System of Instruction (PSI). The units are not intended to be used without outside materials;…

  4. Current Automotive Holometry Studies

    Science.gov (United States)

    Marchi, Mitchell M.; Snyder, D. S.

    1990-04-01

    Holometry studies of automotive body and powertrain components have become a very useful high resolution test methodology to knowledgeable Ford engineering personnel. Current examples of studies that represent the static or dynamic operational conditions of the automotive test component are presented. Continuous wave laser holometry, computer aided holometry (CAH) and pulsed laser holometry were the holometric techniques used to study the following subjects: (1) body in prime (BIP) vibration modes, (2) transmission flexplate stud-torque converter deformation due to engine torque pulses, (3) engine cylinder head and camshaft support structure deformation due to cylinder pressure and (4) engine connecting rod/cap lift-off. Static and dynamic component loading and laboratory techniques required to produce usable and valid test results are discussed along with possible conclusions for the engineering concerns.

  5. The quality of lactation studies including antipsychotics

    NARCIS (Netherlands)

    Hummels, Hazel; Bertholee, Daphne; van der Meer, Douwe; Smit, Jan Pieter; Wilffert, Bob; ter Horst, Peter

    2016-01-01

    The aim of this study is to determine the quality of lactation studies that investigated antipsychotics in breast milk according to the Food and Drug Administration (FDA) and International Lactation Consultant Association (ILCA) draft guidelines. We used the draft FDA and ILCA guidelines to review t

  6. CURRENT STUDIES IN THERMOREGULATION

    Directory of Open Access Journals (Sweden)

    Alfredo Jesús López Dávila

    2014-12-01

    Full Text Available The aim of this review is to present recent advances in the understanding of the physiological mechanisms of thermoregulation in mammals, which can be divided into two types including reflex (or autonomic and behavioral thermoregulation. In reflex thermoregulation, which is totally beyond the voluntary control of the individual, thermoreceptors detect thermal stimuli. Afferent pathways transport information sensed by receptors to the hypothalamus, with relays in the spinal cord and the midbrain. The hypothalamic integration center coordinates its response to the thermal stimuli and sends neural signals through efferent pathways with relays in the medulla and the spinal cord. These signals finally reach effectors that are capable of conserving or dissipating thermal energy in order for body temperature to remain constant. Today, a growing body of evidence suggests considerable physiologic integration between reflex thermoregulation, energy balance and metabolism, which makes considering manipulation of reflex thermoregulation a potential strategy in order to treat metabolic conditions or influence body composition. In behavioral thermoregulation, which relies on voluntary decisions, thermal stimuli are detected by the same receptors. Afferent pathways transport thermal information to the spinal cord, thalamus and cerebral cortex, which influences the perception of thermal comfort and the decisions of the individual in order to gain or lose heat. The recent findings have also brought new questions that are discussed at the end of this review.

  7. Numerical Analysis of Induced Current in Human Head Exposed to Nonuniform Magnetic Field Including Harmonics

    Science.gov (United States)

    Tarao, Hiroo; Hayashi, Noriyuki; Isaka, Katsuo

    In this paper, induced currents in an anatomical head model exposed to a non-uniform ELF magnetic field (B-field) including harmonics are numerically calculated, and are discussed based on the basic restriction established by International Commission on Non-Ionizing Radiation Protection (ICNIRP). A casual hair dryer of 100V and 1.2kW is chosen as a typical source of the non-uniform B-field including both the fundamental and second harmonic components. The B-field distribution around the hair dryer is estimated by using the 3-orthogonal magnetic dipole moments, which are derived from a couple of measured values around it. The high-resolution human head model used is constructed based on the MRI images of a real human, and consists of six kinds of tissues (bone, brain, eyeballs, muscle, skin and blood). So-called impedance method is used for the numerical calculation of the induced current. The numerical results show that the maximum values of the induced current of 17µA/m2, for the 60Hz component, which is about 1/120 of the ICNIRP basic restriction appear in the muscle near the eyeball when the hair dryer is used from the side of the head model, and the averaged current in the eyeballs that have the highest conductivity is the highest among the six tissues. It is also demonstrated that the induced current due to the 120Hz B-field becomes comparable to the 60Hz current although the magnitude of the 120Hz B-field is much smaller than that of the 60Hz B-field.

  8. Numerical analysis of global ionospheric current system including the effect of equatorial enhancement

    Directory of Open Access Journals (Sweden)

    S. Tsunomura

    Full Text Available A modeling method is proposed to derive a two-dimensional ionospheric layer conductivity, which is appropriate to obtain a realistic solution of the polar-originating ionospheric current system including equatorial enhancement. The model can be obtained by modifying the conventional, thin shell conductivity model. It is shown that the modification for one of the non-diagonal terms (Σθφ in the conductivity tensor near the equatorial region is very important; the term influences the profile of the ionospheric electric field around the equator drastically. The proposed model can reproduce well the results representing the observed electric and magnetic field signatures of geomagnetic sudden commencement. The new model is applied to two factors concerning polar-originating ionospheric current systems. First, the latitudinal profile of the DP2 amplitude in the daytime is examined, changing the canceling rate for the dawn-to-dusk electric field by the region 2 field-aligned current. It is shown that the equatorial enhancement would not appear when the ratio of the total amount of the region 2 field-aligned current to that of region 1 exceeds 0.5. Second, the north-south asymmetry of the magnetic fields in the summer solstice condition of the ionospheric conductivity is examined by calculating the global ionospheric current system covering both hemispheres simultaneously. It is shown that the positive relationship between the magnitudes of high latitude magnetic fields and the conductivity is clearly seen if a voltage generator is given as the source, while the relationship is vague or even reversed for a current generator. The new model, based on the International Reference Ionosphere (IRI model, can be applied to further investigations in the quantitative analysis of the magnetosphere-ionosphere coupling problems.

    Key words. Ionosphere (electric fields and currents; equatorial ionosphere; ionosphere

  9. Ancillary Studies, Including Immunohistochemistry and Molecular Studies, in Pancreatic Cytology.

    Science.gov (United States)

    Reid, Michelle D; Centeno, Barbara A

    2014-03-01

    Fine-needle aspiration biopsy of the pancreas is indicated for sampling of solid and cystic masses. Preoperative cytologic diagnosis of pancreatic ductal adenocarcinoma and cystic lesions on cytology can be problematic, and ancillary studies may help confirm diagnosis. Ancillary studies in pancreatic cytology include special stains, immunohistochemistry, mutational analyses of specific genes, cyst fluid analysis of tumor markers and enzymes, and, in some instances, flow cytometry. Proteomics, microRNA sequencing, and whole-exome gene sequencing have been used to illustrate the progression of pancreatic neoplasms and identify key diagnostic markers. This article summarizes recent literature on ancillary studies in pancreatic fine-needle aspiration samples. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Current studies on megapode phylogeny

    NARCIS (Netherlands)

    Brom, T.G.; Dekker, R.W.R.J.

    1992-01-01

    Hypotheses regarding the phylogenetic relationships between megapodes and other birds are reviewed, and it is concluded that the available evidence supports a sistergroup relationship between megapodes and all other galliforms. Current studies in this direction are discussed. The resolvement of intr

  11. Including Alternative Resources in State Renewable Portfolio Standards: Current Design and Implementation Experience

    Energy Technology Data Exchange (ETDEWEB)

    Heeter, J.; Bird, L.

    2012-11-01

    Currently, 29 states, the District of Columbia, and Puerto Rico have instituted a renewable portfolio standard (RPS). An RPS sets a minimum threshold for how much renewable energy must be generated in a given year. Each state policy is unique, varying in percentage targets, timetables, and eligible resources. This paper examines state experience with implementing renewable portfolio standards that include energy efficiency, thermal resources, and non-renewable energy and explores compliance experience, costs, and how states evaluate, measure, and verify energy efficiency and convert thermal energy. It aims to gain insights from the experience of states for possible federal clean energy policy as well as to share experience and lessons for state RPS implementation.

  12. [Current status of autism studies].

    Science.gov (United States)

    Kurita, H

    2001-01-01

    The current status of autism studies was reviewed based on English articles published during the 1990s. Although the concepts of autism and pervasive developmental disorders (PDD) are established, diagnostic criteria of PDDNOS or atypical autism, which is frequently difficult to differentiate from autism, need to be established. The prevalence of autism has been estimated as about 0.05% in the U.S and many European countries, while it was reported to be 0.1% or higher in Japan and some European countries, though the reasons for this difference are unclear. High-functioning (IQ > or = 70) autism may not be as rare a condition as previously thought and both its difference from and similarity to Asperger's syndrome, the highest functioning PDD subtype, need clarification. About 20 to 40% of children with autism lose meaningful words by the age of 2 years and display autistic symptoms thereafter. Such autism, called the setback type in Japan, has been demonstrated to have a poorer adolescent/adult outcome compared to autism without setback and its relationship with childhood disintegrative disorder, which displays a clearer regression after normal development for at least the first 2 years of life, needs to be addressed. The etiology of autism is now considered mostly genetic for reasons, such as the significantly higher concordance rate of autism in identical twin pairs (60-80%) than in fraternal twin pairs (0-10%) and an 3-5% incidence of autism among sibs of an autism proband, 30 to 100 times higher than that in the general population. The involvement of several genes is implicated to create susceptibility for autism, yet the responsible genes have not been identified. Although there is no medication to cure autism, some psychotropic drugs, such as antipsychotics and SSRIs, seem effective for behavior problems in autism patients. Psychosocial treatments are the main therapeutic approach to autism, though they are yet to be well systematized. It is important to

  13. Electrolytic/fuel cell bundles and systems including a current collector in communication with an electrode thereof

    Science.gov (United States)

    Hawkes, Grant L.; Herring, James S.; Stoots, Carl M.; O& #x27; Brien, James E.

    2013-03-05

    Electrolytic/fuel cell bundles and systems including such bundles include an electrically conductive current collector in communication with an anode or a cathode of each of a plurality of cells. A cross-sectional area of the current collector may vary in a direction generally parallel to a general direction of current flow through the current collector. The current collector may include a porous monolithic structure. At least one cell of the plurality of cells may include a current collector that surrounds an outer electrode of the cell and has at least six substantially planar exterior surfaces. The planar surfaces may extend along a length of the cell, and may abut against a substantially planar surface of a current collector of an adjacent cell. Methods for generating electricity and for performing electrolysis include flowing current through a conductive current collector having a varying cross-sectional area.

  14. Equivalent Circuit for Cavity Discharges Including Controlled Current Source and Controlled Switch

    Institute of Scientific and Technical Information of China (English)

    CHEN Weigen; CHEN Xi; XIE Bo; LIU Jun

    2013-01-01

    Numerous equivalent circuits for cavity discharges have been developed,yet most of these models cannot provide simulated signals that precisely reveal the variability of the discharge's characteristic parameters,such as repetition rate,magnitude and phase of discharges,which makes them not suitable for intensive studies of discharge process.Therefore,using Simulink code,we theoretically analyzed and studied the classical equivalent circuits of cavity discharges,as well as the influence of circuit components on simulation results,and then proposed a novel equivalent circuit,the key parameters of which were determined according to the physical behavior of cavity discharges.In the novel equivalent circuit,the repetition rate can be changed by discharge resistance,inception and residual voltages;meanwhile the phase of discharge can be controlled by adjusting the parameters of shunt resistance.Furthermore,a controlled current source as a function of space charge is introduced in the equivalent circuit.Compared with the former ones,the simulated signals obtained by this novel model are better approximation of real signals.This work could be referred by latter studies of the characteristics and the mechanisms of cavity discharge in oil-paper insulation.

  15. [Current studies in myotonic dystrophy].

    Science.gov (United States)

    Zhao, Yimeng; Ishiura, Shoichi

    2014-03-01

    Myotonic dystrophy (DM) is a genetic, progressive, multisystemic disease with muscular disorder as its primary symptom. There are two types of DM (DM1 and DM2) caused by mutations in different genes, and in Japan, DM occurs with an incidence of approximately 1 in 20,000. The pathogenic mechanism underlying the disease is RNA toxicity caused by transcripts of aberrantly elongated CTG or CCTG repeats located in the 3' untranslated region or in the intron. The current treatments for DM is limited to symptomatic care. In this review, we will discuss several new therapeutic strategies based on recent studies of RNA toxicity.

  16. 75 FR 22630 - Nautilus, Inc., Currently Known as Med-Fit Systems Incorporated, Commercial Division, Including...

    Science.gov (United States)

    2010-04-29

    ..., Virginia. The notice was published in the Federal Register on February 16th, 2010 (75 FR 7032). At the... Employment and Training Administration Nautilus, Inc., Currently Known as Med-Fit Systems Incorporated.... was sold in September 2009 and is currently known as Med-Fit Systems, Incorporated. Some...

  17. Current developments in avian influenza vaccines, including safety of vaccinated birds as food.

    Science.gov (United States)

    Swayne, D E; Suarez, D L

    2007-01-01

    Until recently, most vaccines against avian influenza were based on oil-emulsified inactivated low- or high-pathogenicity viruses. Now, recombinant fowl pox and avian paramyxovirus type 1 vaccines with avian influenza H5 gene inserts (+ or - N1 gene insert) are available and licensed. New technologies might overcome existing limitations to make available vaccines that can be grown in tissue culture systems for more rapid production; provide optimized protection, as a result of closer genetic relations to field viruses; allow mass administration by aerosol, in drinking-water or in ovo; and allow easier strategies for identifying infected birds within vaccinated populations (DIVA). The technologies include avian influenza viruses with partial gene deletions, avian influenza-Newcastle disease virus chimeras, vectored vaccines such as adenoviruses and Marek's disease virus, and subunit vaccines. These new methods should be licensed only after their purity, safety, efficacy and potency against avian influenza viruses have been demonstrated, and, for live vectored vaccines, restriction of viral transmission to unvaccinated birds. Use of vaccines in countries affected by highly pathogenic avian influenza will not only protect poultry but will provide additional safety for consumers. Experimental studies have shown that birds vaccinated against avian influenza have no virus in meat and minimal amounts in eggs after HPAI virus challenge, and that replication and shedding from their respiratory and alimentary tracts is greatly reduced.

  18. Cellulite treatment: evidence and ethics, brief history, and emphasis on current practices including liposuction

    Science.gov (United States)

    de Riese, Cornelia

    2005-04-01

    According to Taber's Cyclopedic Medical Dictionary "cellulite" is defined as: "a non-technical term for subcutaneous deposits of fat, especially in the buttocks, legs, and thighs." These deposits result in puckered, dimply skin and they are a cause for major aesthetic concerns in affected patients. The etiology of this condition is still unclear. Female predilection is witnessed in clinical practice as it is reported in the literature. It remains a subject for further studies whether it is a structural problem of connective tissue or as suggested probably related to hormonal causes. Magnetic resonance imaging may provide some answers to these questions. Not knowing what is causing this nuisance makes it almost impossible to treat. No wonder that there is little scientific validation to support any of the many treatments that are advertised on the Internet or in women's magazines. This review focuses on mechanical and microinvasive interventions that claim to alleviate "cellulite": lipoplasty, liposcultpure, liposuction, subcision, and laser. Among the parameters analyzed are the proposed modes of action of these techniques as well as adverse events and complications that may occur. Of special interest will be the evidence that backs these procedures. Extracting reliable data is hampered by methodical problems with the design of most of the published trials. In essence, at this time there is no "cure" for cellulite. Safe treatment recommendations are related to healthy life style choices that include toning exercises, dietary changes, and weight loss.

  19. 75 FR 70688 - Actel Corporation, Currently Known as Microsemi Corporation, Including On-Site Leased Workers...

    Science.gov (United States)

    2010-11-18

    ... On-Site Leased Workers From ATR International, Accountants, Inc. and Accountant Temps Mountain View... International, Accountants, Inc., and Accountant Temps, Mountain View, California. The notice was published in... Microsemi Corporation, including on-site leased workers from ATE International, Accountants, Inc.,...

  20. Current Changes in Pubertal Timing: Revised Vision in Relation with Environmental Factors Including Endocrine Disruptors.

    Science.gov (United States)

    Parent, Anne-Simone; Franssen, Delphine; Fudvoye, Julie; Pinson, Anneline; Bourguignon, Jean-Pierre

    2016-01-01

    The aim of this chapter is to revise some common views on changes in pubertal timing. This revision is based on recent epidemiological findings on the clinical indicators of pubertal timing and data on environmental factor effects and underlying mechanisms. A current advancement in timing of female puberty is usually emphasized. It appears, however, that timing is also changing in males. Moreover, the changes are towards earliness for initial pubertal stages and towards lateness for final stages in both sexes. Such observations indicate the complexity of environmental influences on pubertal timing. The mechanisms of changes in pubertal timing may involve both the central neuroendocrine control and peripheral effects at tissues targeted by gonadal steroids. While sufficient energy availability is a clue to the mechanism of pubertal development, changes in the control of both energy balance and reproduction may vary under the influence of common determinants such as endocrine-disrupting chemicals (EDCs). These effects can take place right before puberty as well as much earlier, during fetal and neonatal life. Finally, environmental factors can interact with genetic factors in determining changes in pubertal timing. Therefore, the variance in pubertal timing is no longer to be considered under absolutely separate control by environmental and genetic determinants. Some recommendations are provided for evaluation of EDC impact in the management of pubertal disorders and for possible reduction of EDC exposure along the precautionary principle.

  1. Including History in the Study of Psychological and Political Power

    Science.gov (United States)

    Reich, Stephanie M.; Pinkard, Tracy; Davidson, Heather

    2008-01-01

    Isaac Prilleltensky's (2003) concept of psychopolitical validity stresses the need to consider both the political and the psychological nature of power in the study of wellness, oppression, and liberation. The authors advocate that psychopolitical validity would be strengthened if it included an explicit appreciation of historical context. The…

  2. Including History in the Study of Psychological and Political Power

    Science.gov (United States)

    Reich, Stephanie M.; Pinkard, Tracy; Davidson, Heather

    2008-01-01

    Isaac Prilleltensky's (2003) concept of psychopolitical validity stresses the need to consider both the political and the psychological nature of power in the study of wellness, oppression, and liberation. The authors advocate that psychopolitical validity would be strengthened if it included an explicit appreciation of historical context. The…

  3. Studying Irony Detection Beyond Ironic Criticism: Let's Include Ironic Praise.

    Science.gov (United States)

    Bruntsch, Richard; Ruch, Willibald

    2017-01-01

    unique variance in irony detection, ironic praise can be postulated as worthwhile to include in future studies-especially when studying the role of mental ability, personality, and humor in irony detection.

  4. Non-linear Simulations of MHD Instabilities in Tokamaks Including Eddy Current Effects and Perspectives for the Extension to Halo Currents

    Science.gov (United States)

    Hoelzl, M.; Huijsmans, G. T. A.; Merkel, P.; Atanasiu, C.; Lackner, K.; Nardon, E.; Aleynikova, K.; Liu, F.; Strumberger, E.; McAdams, R.; Chapman, I.; Fil, A.

    2014-11-01

    The dynamics of large scale plasma instabilities can be strongly influenced by the mutual interaction with currents flowing in conducting vessel structures. Especially eddy currents caused by time-varying magnetic perturbations and halo currents flowing directly from the plasma into the walls are important. The relevance of a resistive wall model is directly evident for Resistive Wall Modes (RWMs) or Vertical Displacement Events (VDEs). However, also the linear and non-linear properties of most other large-scale instabilities may be influenced significantly by the interaction with currents in conducting structures near the plasma. The understanding of halo currents arising during disruptions and VDEs, which are a serious concern for ITER as they may lead to strong asymmetric forces on vessel structures, could also benefit strongly from these non-linear modeling capabilities. Modeling the plasma dynamics and its interaction with wall currents requires solving the magneto-hydrodynamic (MHD) equations in realistic toroidal X-point geometry consistently coupled with a model for the vacuum region and the resistive conducting structures. With this in mind, the non-linear finite element MHD code JOREK [1, 2] has been coupled [3] with the resistive wall code STARWALL [4], which allows us to include the effects of eddy currents in 3D conducting structures in non-linear MHD simulations. This article summarizes the capabilities of the coupled JOREK-STARWALL system and presents benchmark results as well as first applications to non-linear simulations of RWMs, VDEs, disruptions triggered by massive gas injection, and Quiescent H-Mode. As an outlook, the perspectives for extending the model to halo currents are described.

  5. A study of model bivalve siphonal currents

    Science.gov (United States)

    Monismith, Stephen G.; Koseff, Jeffrey R.; Thompson, Janet K.; O'Riordan, Catherine A.; Nepf, Heidi M.

    1990-01-01

    We carried out experiments studying the hydrodynamics of bivalve siphonal currents in a laboratory flume. Rather than use living animals, we devised a simple, model siphon pair connected to a pump. Fluorescence-based flow visualization was used to characterize siphon-jet flows for several geometric configurations and flow speeds. These measurements show that the boundary-layer velocity profile, siphon height, siphon pair orientation, and size of siphon structure all affect the vertical distribution of the excurrent flow downstream of the siphon pair and the fraction of excurrent that is refiltered. The observed flows may effect both the clearance rate of an entire population of siphonate bivalves as well as the efficiency of feeding of any individual. Our results imply that field conditions are properly represented in laboratory flume studies of phytoplankton biomass losses to benthic bivalves when the shear velocity and bottom roughness are matched to values found in the field. Numerical models of feeding by a bivalve population should include an effective sink distribution which is created by the combined incurrent-excurrent flow field. Near-bed flows need to be accounted for to properly represent these benthic-pelagic exchanges. We also present velocity measurements made with a laser-Doppler anemometer (LDA) for a single configuration (siphons flush with bed, inlet downstream) that show that the siphonal currents have a significant local effect on the properties of a turbulent boundary layer.

  6. Study on `Tannix` an absorbent for heavy metals including uranium

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Yasuo [Mitsubishi Nuclear Fuel Co. Ltd., Tokyo (Japan)

    1997-09-01

    To treat radioactive wastes including uranium and transuranic elements such as plutonium, americium etc., development of an absorbent which can be used to absorb and isolate these elements without producing secondary wastes after treatment was attempted. And an absorbent has been successfully developed by polymerizing tannin, a natural product. It is known that tannin binds heavy metals including uranium resulting to produce their precipitates. There are some reports suggesting its absorption ability for uranium. However, tannin has not been used to isolate a heavy metal from a solution because it is soluble in water. Here, insolubilization of tannin was attempted and a manufacturing method for a gelatinized insoluble tannin named as ``Tannix`` was established. Wattle tannin extracted from Mimosa pudica produced in Africa was dissolved in an alkaline solution and gelatinized by heating after the addition of formalin. Thus obtained insoluble tannin was used after crushing and sieving. This product, ``Tannix`` was able to absorb more than 99% of uranium in the waste. And the absorbed Tannin could be degraded by incineration even at a low temperature, leaving only uranium, but not producing any secondary product. (M.N.)

  7. Peace psychology should include the study of peaceful individuals.

    Science.gov (United States)

    Nelson, Linden L

    2014-09-01

    The selection of topics for the special issue on peace psychology (October 2013) probably gave readers the impression that peace psychology should be defined as the study of conflict and peace at intergroup, societal, and global levels.

  8. Guide to speed study techniques including speed reading and memorization

    CERN Document Server

    Team, The Hyperink

    2012-01-01

    ABOUT THE BOOK Most students are familiar with that sense of rising panic when, close to a deadline for a paper or the date of an exam, they realize that they know almost nothing about the subject at hand. Some students can take this situation in their stride, and some fall to pieces, getting lost amid the maze of books and tangling themselves into mental knots. When we first embark on a course of study, we are often thrown in at the deep end and left to sink or swim. Studying is a skill, not something we are born with a natural aptitude for. If you find yourself struggling in your course

  9. A Physics-Based Charge-Control Model for InP DHBT Including Current-Blocking Effect

    Institute of Scientific and Technical Information of China (English)

    GE Ji; JIN Zhi; SU Yong-Bo; CHENG Wei; WANG Xian-Wai; CHEN Gao-Peng; LIU Xin-Yu

    2009-01-01

    We develop a physics-based charge-control InP double heterojunction bipolar transistor model including three important effects: current blocking, mobile-charge modulation of the base-collector capacitance and velocity-field modulation in the transit time. The bias-dependent base-collector depletion charge is obtained analytically, which takes into account the mobile-charge modulation. Then, a measurement based voltage-dependent transit time formulation is implemented. As a result, over a wide range of biases, the developed model shows good agreement between the modeled and measured S-parameters and cutoff frequency. Also, the model considering current blocking effect demonstrates more accurate prediction of the output characteristics than conventional vertical bipolar inter company results.

  10. Theoretical studies of non inductive current drive in compact toroids

    NARCIS (Netherlands)

    Farengo, R; Lifschitz, AF; Caputi, KI; Arista, NR; Clemente, RA

    2002-01-01

    Three non inductive current drive methods that can be applied to compact toroids axe studied. The use of neutral beams to drive current in field reversed configurations and spheromaks is studied using a Monte Carlo code that includes a complete ionization package and follows the exact particle orbit

  11. Study of longshore current equations for currents in Visakhapatnam beach

    Digital Repository Service at National Institute of Oceanography (India)

    Chandramohan, P.; Rao, T.V.N.

    Longshore currents were measured along the Visakhapatnam Beach, Andhra Pradesh, India at weekly intervals from March 1978 to March 1979. Visual observations on breaker characteristics were also made during this period. Using modified Longuet...

  12. The Current Canon in British Romantics Studies.

    Science.gov (United States)

    Linkin, Harriet Kramer

    1991-01-01

    Describes and reports on a survey of 164 U.S. universities to ascertain what is taught as the current canon of British Romantic literature. Asserts that the canon may now include Mary Shelley with the former standard six major male Romantic poets, indicating a significant emergence of a feminist perspective on British Romanticism in the classroom.…

  13. Studies of Current Dependent Effects at ANKA

    CERN Document Server

    Müller, A S; Huttel, E; Pérez, F; Pont, M; Zimmermann, Frank

    2004-01-01

    The ANKA electron storage ring is operated at energies between 0.5 and 2.5 GeV. A major requirement for a synchrotron light source, such as ANKA, is to achieve a high beam current. A multitude of mostly impedance related effects depend on either bunch or total beam current. This paper gives an overview over the various beam studies performed at ANKA in this context, specifically the observation of current dependent detuning, the determination of the bunch length change with current from a measurement of the ratio between coherent and incoherent synchrotron tune and an assessment of the effective longitudinal loss factor from the current dependent horizontal closed orbit distortion.

  14. A unified analytical drain current model for Double-Gate Junctionless Field-Effect Transistors including short channel effects

    Science.gov (United States)

    Raksharam; Dutta, Aloke K.

    2017-04-01

    In this paper, a unified analytical model for the drain current of a symmetric Double-Gate Junctionless Field-Effect Transistor (DG-JLFET) is presented. The operation of the device has been classified into four modes: subthreshold, semi-depleted, accumulation, and hybrid; with the main focus of this work being on the accumulation mode, which has not been dealt with in detail so far in the literature. A physics-based model, using a simplified one-dimensional approach, has been developed for this mode, and it has been successfully integrated with the model for the hybrid mode. It also includes the effect of carrier mobility degradation due to the transverse electric field, which was hitherto missing in the earlier models reported in the literature. The piece-wise models have been unified using suitable interpolation functions. In addition, the model includes two most important short-channel effects pertaining to DG-JLFETs, namely the Drain Induced Barrier Lowering (DIBL) and the Subthreshold Swing (SS) degradation. The model is completely analytical, and is thus computationally highly efficient. The results of our model have shown an excellent match with those obtained from TCAD simulations for both long- and short-channel devices, as well as with the experimental data reported in the literature.

  15. 75 FR 69470 - Tele Atlas North America, Inc., Currently Doing Business as Tom Tom Including Off-Site Workers...

    Science.gov (United States)

    2010-11-12

    ... Employment and Training Administration Tele Atlas North America, Inc., Currently Doing Business as Tom Tom... Doing Business as Tom Tom, Concord, MA; Tele Atlas North America, Inc. Currently Doing Business as Tom Tom, Detroit, MI; Tele Atlas North America, Inc. Currently Doing Business as Tom Tom, Redwood, CA...

  16. Multiscale Study of Currents Affected by Topography

    Science.gov (United States)

    2015-09-30

    boundary layers to influence the ambient larger-scale flow. We have studied these issues through ocean model simulations, adjoint sensitivity...circulation be monitored from pressure gauges, temperature sensors, current meters, or other measurements near the feature? • The influence of the

  17. A mechanism for the dynamo terms to sustain closed-flux current, including helicity balance, by driving current which crosses the magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Jarboe, T. R.; Nelson, B. A.; Sutherland, D. A. [University of Washington, Seattle, Washington 98195 (United States)

    2015-07-15

    An analysis of imposed dynamo current drive (IDCD) [T.R. Jarboe et al., Nucl. Fusion 52 083017 (2012)] reveals: (a) current drive on closed flux surfaces seems possible without relaxation, reconnection, or other flux-surface-breaking large events; (b) the scale size of the key physics may be smaller than is often computationally resolved; (c) helicity can be sustained across closed flux; and (d) IDCD current drive is parallel to the current which crosses the magnetic field to produce the current driving force. In addition to agreeing with spheromak data, IDCD agrees with selected tokamak data.

  18. The ENIQ pilot study: current status

    Energy Technology Data Exchange (ETDEWEB)

    Lemaitre, P.; Eriksen, B.; Crutzen, S. [European Commission, DG Joint Research Centre, Petten (Netherlands); Hansch, M. [Preussische Elektrizitaets-AG (Preussenelektra), Hannover (Germany); Whittle, J. [AEA Technology, Warrington (United Kingdom)

    1998-11-01

    A pilot study is currently being carried out by ENIQ (European Network for Inspection Qualification) in order to explore the issues involved in inspection qualification applied along the general principles of the European methodology. The components selected for the pilot study are austenitic pipe to pipe and pipe to elbows welds typical of those in BWR recirculation loops. A range of defect parameters has been defined. A suitable inspection procedure designed to find the designated defects will be applied to geometrically representative test pieces. The procedure/equipment will be qualified through open trials and technical justification. The personnel qualification will be done in a blind way. Once all features of the inspection system will have been qualified an in-service inspection will be simulated in order to test the feasibility of the qualification approach followed. In this paper the current status of this pilot study is discussed. (orig.)

  19. Non-linear Simulations of MHD Instabilities in Tokamaks Including Eddy Current Effects and Perspectives for the Extension to Halo Currents

    CERN Document Server

    Hoelzl, M; Merkel, P; Atanasiu, C; Lackner, K; Nardon, E; Aleynikova, K; Liu, F; Strumberger, E; McAdams, R; Chapman, I; Fil, A

    2014-01-01

    The dynamics of large scale plasma instabilities can strongly be influenced by the mutual interaction with currents flowing in conducting vessel structures. Especially eddy currents caused by time-varying magnetic perturbations and halo currents flowing directly from the plasma into the walls are important. The relevance of a resistive wall model is directly evident for Resistive Wall Modes (RWMs) or Vertical Displacement Events (VDEs). However, also the linear and non-linear properties of most other large-scale instabilities may be influenced significantly by the interaction with currents in conducting structures near the plasma. The understanding of halo currents arising during disruptions and VDEs, which are a serious concern for ITER as they may lead to strong asymmetric forces on vessel structures, could also benefit strongly from these non-linear modeling capabilities. Modeling the plasma dynamics and its interaction with wall currents requires solving the magneto-hydrodynamic (MHD) equations in realist...

  20. Assessing the Applicability of Currently Available Methods for Attributing Foodborne Disease to Sources, Including Food and Food Commodities

    DEFF Research Database (Denmark)

    Pires, Sara Monteiro

    2013-01-01

    Abstract A variety of approaches to attribute foodborne diseases to specific sources are available, including hazard occurrence analysis, epidemiological methods, intervention studies, and expert elicitations. The usefulness of each method to attribute disease caused by a foodborne hazard depends...... on the public health question being addressed, on the data requirements, on advantages and limitations of the method, and on the data availability of the country or region in question. Previous articles have described available methods for source attribution, but have focused only on foodborne microbiological...

  1. 78 FR 75560 - Green Current Solutions, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2013-12-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Green Current Solutions, LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding, of Green Current Solutions, LLC's application for market-based...

  2. [Current registry studies of acute ischemic stroke].

    Science.gov (United States)

    Veltkamp, R; Jüttler, E; Pfefferkorn, T; Purrucker, J; Ringleb, P

    2012-10-01

    Study registries offer the opportunity to evaluate the effects of new therapies or to observe the consequences of new treatments in clinical practice. The SITS-MOST registry confirmed the validity of findings from randomized trials on intravenous thrombolysis concerning safety and efficacy in the clinical routine. Current study registries concerning new interventional thrombectomy techniques suggest a high recanalization rate; however, the clinical benefit can only be evaluated in randomized, controlled trials. Similarly, the experiences of the BASICS registry on basilar artery occlusion have led to the initiation of a controlled trial. The benefit of hemicraniectomy in malignant middle cerebral artery infarction has been demonstrated by the pooled analysis of three randomized trials. Numerous relevant aspects are currently documented in the DESTINY-R registry. Finally, the recently started RASUNOA registry examines diagnostic and therapeutic aspects of ischemic and hemorrhagic stroke occurring during therapy with new oral anticoagulants.

  3. The value of including observational studies in systematic reviews was unclear: a descriptive study.

    Science.gov (United States)

    Seida, Jennifer; Dryden, Donna M; Hartling, Lisa

    2014-12-01

    To evaluate (1) how often observational studies are included in comparative effectiveness reviews (CERs); (2) the rationale for including observational studies; (3) how data from observational studies are appraised, analyzed, and graded; and (4) the impact of observational studies on strength of evidence (SOE) and conclusions. Descriptive study of 23 CERs published through the Effective Health Care Program of the U.S. Agency for Healthcare Research and Quality. Authors searched for observational studies in 20 CERs, of which 18 included a median of 11 (interquartile range, 2-31) studies. Sixteen CERs incorporated the observational studies in their SOE assessments. Seventy-eight comparisons from 12 CERs included evidence from both trials and observational studies; observational studies had an impact on SOE and conclusions for 19 (24%) comparisons. There was diversity across the CERs regarding decisions to include observational studies; study designs considered; and approaches used to appraise, synthesize, and grade SOE. Reporting and methods guidance are needed to ensure clarity and consistency in how observational studies are incorporated in CERs. It was not always clear that observational studies added value in light of the additional resources needed to search for, select, appraise, and analyze such studies. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. Assessing the applicability of currently available methods for attributing foodborne disease to sources, including food and food commodities.

    Science.gov (United States)

    Pires, Sara M

    2013-03-01

    A variety of approaches to attribute foodborne diseases to specific sources are available, including hazard occurrence analysis, epidemiological methods, intervention studies, and expert elicitations. The usefulness of each method to attribute disease caused by a foodborne hazard depends on the public health question being addressed, on the data requirements, on advantages and limitations of the method, and on the data availability of the country or region in question. Previous articles have described available methods for source attribution, but have focused only on foodborne microbiological hazards. These articles have described strengths and weaknesses of each method, but no guidance on how to choose the most appropriate tool to address different public health questions has thus far been provided. We reviewed available source attribution methods; assessed their applicability to attribute illness caused by enteric, parasitic, and chemical foodborne hazards to the responsible sources; and renamed some of the approaches. The main objective was to make recommendations on the most appropriate method(s) to attribute human disease caused by different foodborne hazards. We concluded that the proportion of disease that can be attributed to specific foods items or transmission routes may be estimated for the majority of the evaluated hazards by applying one or more of the source attribution methods assessed. It was also recognized that the use of source attribution methods may be limited to specific countries, reflecting the data availability.

  5. A study on the enhancement of nuclear cooperation with African countries including utilization of radioisotope

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Maeng Ho; Oh, K. B; Lee, H. M. and others

    2005-05-15

    In this study, potential countries for nuclear cooperation in African region and possible cooperation areas were investigated between Korea and African countries including radioisotopes and more fields were also analysed in depth in order to suggest the recommendations for future cooperation to be considered as follows; First, current status and perspectives of demand and supply of energy and electricity in the African countries, use and development of nuclear energy and international nuclear cooperation were analyzed. Second, current status of nuclear cooperation between Korea and African countries were investigated as well as analysis of future cooperation potential and countries having potential for nuclear cooperation and possible cooperative activities were suggested considering potential of nuclear market in mid- and long term base and step by step. Third, desirable strategies and directions for the establishment and promotion of nuclear cooperation relations between Korea and African developing countries were suggested in order to develope cooperative relations in efficient and effective manners with African developing countries.

  6. A western boundary current eddy characterisation study

    Science.gov (United States)

    Ribbe, Joachim; Brieva, Daniel

    2016-12-01

    The analysis of an eddy census for the East Australian Current (EAC) region yielded a total of 497 individual short-lived (7-28 days) cyclonic and anticyclonic eddies for the period 1993 to 2015. This was an average of about 23 eddies per year. 41% of the tracked individual cyclonic and anticyclonic eddies were detected off southeast Queensland between about 25 °S and 29 °S. This is the region where the flow of the EAC intensifies forming a swift western boundary current that impinges near Fraser Island on the continental shelf. This zone was also identified as having a maximum in detected short-lived cyclonic eddies. A total of 94 (43%) individual cyclonic eddies or about 4-5 per year were tracked in this region. The census found that these potentially displaced entrained water by about 115 km with an average displacement speed of about 4 km per day. Cyclonic eddies were likely to contribute to establishing an on-shelf longshore northerly flow forming the western branch of the Fraser Island Gyre and possibly presented an important cross-shelf transport process in the life cycle of temperate fish species of the EAC domain. In-situ observations near western boundary currents previously documented the entrainment, off-shelf transport and export of near shore water, nutrients, sediments, fish larvae and the renewal of inner shelf water due to short-lived eddies. This study found that these cyclonic eddies potentially play an important off-shelf transport process off the central east Australian coast.

  7. Comparison on Heat of Hydration between Current Concrete for NPP and High Fluidity Concrete including Pozzolan Powders

    Energy Technology Data Exchange (ETDEWEB)

    Noh, Jea Myoung; Cho, Myung Sug [KEPCO Research Institute, Daejeon (Korea, Republic of)

    2010-10-15

    Nuclear power plant (NPP) concrete structures are exposed to many construction factors that lower the quality of concrete due to densely packed reinforcements and heat of hydration since they are mostly constructed with mass concrete. The concrete currently being used in Korean NPPs is mixed with Type I cement and fly ash. However, there is a demand to improve the performance of concrete with reduced heat of hydration and superior constructability. Many advantages such as improving workability and durability of concrete and decreasing heat of hydration are introduced by replacing cement with pozzolan binders. Therefore, the manufacturing possibility of high fluidity concrete should be investigated through applying multi-component powders blended with pozzolan binders to the concrete structure of NPPs, while the researches on properties, characteristic of hydration, durability and long-term behavior of high fluidity concrete using multi-component cement should be carried out. High fluidity concrete which is made using portland cement and pozzlonan powders such as fly ash and blast furnace slag has better properties on heat of hydration than the concrete currently in use for NPPs

  8. Recent Advances in Studies of Current Noise

    Science.gov (United States)

    Blanter, Yaroslav M.

    This is a brief review of recent activities in the field of current noise intended for newcomers. We first briefly discuss main properties of shot noise in nanostructures, and then turn to recent developments, concentrating on issues related to experimental progress: non-symmetrized cumulants and quantum noise; counting statistics; super-Poissonian noise; current noise and interferometry

  9. Should the current DSM-IV-TR definition for PTSD be expanded to include serial and multiple microtraumas as aetiologies?

    Science.gov (United States)

    Seides, R

    2010-10-01

    Post-traumatic stress disorder (PTSD) is an anxiety disorder that develops from events that are interpreted as traumatic. It may be secondary to witnessing trauma to someone close, an event that threatens one's life or childhood sexual trauma. Resultant feelings can be fear, helplessness or horror. Thresholds at which traumatic events cause PTSD, the individual's coping ability and support systems help determine occurrence and severity of symptoms. According to DSM-IV-TR (DSM) definition, PTSD can occur after childhood sexual abuse or a single trauma threatening life or safety. However, it is becoming clearer that symptoms of PTSD can arise from multiple less severe traumas ('microtraumas'), which can be a consequence of a history of longstanding emotional neglect, humiliation or inaccurate attribution of blame. The DSM should consider modifying the criteria to include multiple microtraumas that can lead to PTSD symptoms and may even be more destructive to psychological health.

  10. Quantifying the Earthquake Clustering that Independent Sources with Stationary Rates (as Included in Current Risk Models) Can Produce.

    Science.gov (United States)

    Fitzenz, D. D.; Nyst, M.; Apel, E. V.; Muir-Wood, R.

    2014-12-01

    The recent Canterbury earthquake sequence (CES) renewed public and academic awareness concerning the clustered nature of seismicity. Multiple event occurrence in short time and space intervals is reminiscent of aftershock sequences, but aftershock is a statistical definition, not a label one can give an earthquake in real-time. Aftershocks are defined collectively as what creates the Omori event rate decay after a large event or are defined as what is taken away as "dependent events" using a declustering method. It is noteworthy that depending on the declustering method used on the Canterbury earthquake sequence, the number of independent events varies a lot. This lack of unambiguous definition of aftershocks leads to the need to investigate the amount of clustering inherent in "declustered" risk models. This is the task we concentrate on in this contribution. We start from a background source model for the Canterbury region, in which 1) centroids of events of given magnitude are distributed using a latin-hypercube lattice, 2) following the range of preferential orientations determined from stress maps and focal mechanism, 3) with length determined using the local scaling relationship and 4) rates from a and b values derived from the declustered pre-2010 catalog. We then proceed to create tens of thousands of realizations of 6 to 20 year periods, and we define criteria to identify which successions of events in the region would be perceived as a sequence. Note that the spatial clustering expected is a lower end compared to a fully uniform distribution of events. Then we perform the same exercise with rates and b-values determined from the catalog including the CES. If the pre-2010 catalog was long (or rich) enough, then the computed "stationary" rates calculated from it would include the CES declustered events (by construction, regardless of the physical meaning of or relationship between those events). In regions of low seismicity rate (e.g., Canterbury before

  11. Current studies on myofascial pain syndrome.

    Science.gov (United States)

    Kuan, Ta-Shen

    2009-10-01

    Recent studies have clarified the nature of myofascial trigger points (MTrPs). In an MTrP region, multiple hyperirritable loci can be found. The sensory components of the MTrP locus are sensitized nociceptors that are responsible for pain, referred pain, and local twitch responses. The motor components are dysfunctional endplates that are responsible for taut band formation as a result of excessive acetylcholine (ACh) leakage. The concentrations of pain- and inflammation-related substances are increased in the MTrP region. It has been hypothesized that excessive ACh release, sarcomere shortening, and release of sensitizing substances are three essential features that relate to one another in a positive feedback cycle. This MTrP circuit is the connection among spinal sensory (dorsal horn) neurons responsible for the MTrP phenomena. Recent studies suggest that measurement of biochemicals associated with pain and inflammation in the MTrP region, the sonographic study of MTrPs, and the magnetic resonance elastography for taut band image are potential tools for the diagnosis of MTrPs. Many methods have been used to treat myofascial pain, including laser therapy, shockwave therapy, and botulinum toxin type A injection.

  12. Current management of bronchiectasis: review and 3 case studies.

    Science.gov (United States)

    Silverman, Enid; Ebright, Linda; Kwiatkowski, Marianne; Cullina, Joanne

    2003-01-01

    Bronchiectasis is the abnormal, irreversible dilatation of diseased bronchi. Permanently dilated airways, usually in the medium-sized bronchi, are inflamed and often obstructed with thick, purulent secretions. Known causative factors include postinfection bronchial damage, postinhalation injury, hypersensitivity reactions, and congenital airway obstructive disorders. Typical symptoms include sputum overproduction, fever, pleurisy, dyspnea, and chronic cough. Diagnosis involves radiographic studies and pulmonary function testing. Treatment includes oral, aerosolized, or intravenous antibiotic therapy according to the severity of the exacerbation, and mucus clearance by means of bronchial hygiene assistive devices, chest physiotherapy, postural drainage, and high-frequency chest compression. We present a review of bronchiectasis and offer 3 case studies illustrating current management of different presentations, including use of aerosolized antibiotics for patients infected with Pseudomonas aeruginosa. Although an adjunctive program of pulmonary rehabilitation may be useful for patients with bronchiectasis, no confirming studies have been performed to date, and additional research in this area is warranted.

  13. Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children.

    Science.gov (United States)

    Cates, Christopher J; Karner, Charlotta

    2013-04-30

    Traditionally inhaled treatment for asthma has used separate preventer and reliever therapies. The combination of formoterol and budesonide in one inhaler has made possible a single inhaler for both prevention and relief of symptoms (single inhaler therapy or SiT). To assess the efficacy and safety of budesonide and formoterol in a single inhaler for maintenance and reliever therapy in asthma compared with maintenance with inhaled corticosteroids (ICS) (alone or as part of current best practice) and any reliever therapy. We searched the Cochrane Airways Group trials register in February 2013. Parallel, randomised controlled trials of 12 weeks or longer in adults and children with chronic asthma. Studies had to assess the combination of formoterol and budesonide as SiT, against a control group that received inhaled steroids and a separate reliever inhaler. We used standard methodological procedures expected by The Cochrane Collaboration. We included 13 trials involving 13,152 adults and one of the trials also involved 224 children (which have been separately reported). All studies were sponsored by the manufacturer of the SiT inhaler. We considered the nine studies assessing SiT against best practice to be at a low risk of selection bias, but a high risk of detection bias as they were unblinded.In adults whose asthma was not well-controlled on ICS, the reduction in hospital admission with SiT did not reach statistical significance (Peto odds ratio (OR) 0.81; 95% confidence interval (CI) 0.45 to 1.44, eight trials, N = 8841, low quality evidence due to risk of detection bias in open studies and imprecision). The rates of hospital admission were low; for every 1000 people treated with current best practice six would experience a hospital admission over six months compared with between three and eight treated with SiT. The odds of experiencing exacerbations needing treatment with oral steroids were lower with SiT compared with control (OR 0.83; 95% CI 0.70 to 0

  14. Current methods for studying dynamic processes in the ionosphere

    Science.gov (United States)

    Filipp, Nikolai D.; Blaunshtein, Natan Sh.; Erukhimov, Lev M.; Ivanov, Vladimir A.; Uriadov, Valerii P.

    Current experimental and theoretical data relevant to the study of dynamic processes in the ionospheric plasma using state-of-the-art methods are summarized. The methods used include linear FM sounding, partial radio wave reflection, oblique-incidence radio wave scattering, radio wave heating of the ionosphere, plasma injection, and computer simulation of physical processes. For each specific method, experimental data are compared against theoretical predictions and numerical calculations.

  15. AN EMPIRICAL STUDY OF CURRENT RATIO

    Directory of Open Access Journals (Sweden)

    Atanas Delev

    2014-10-01

    Full Text Available This work aims to address problems of liquidity and in particular the values and factors that influenced the values of the coefficient of total liquidity sixty Bulgarian public companies for the period 2013 - 2007 year. In the analysis it was found that some businesses fail to achieve favorable values of the ratio between current assets and current liabilities. It was found that plants have a low level of total liquidity, which can create problems in repayment of short-term liabilities. It can be seen that there are companies with very high liquidity, which is not so good phenomenon, ie the retention of a high level of resources required. Businesses should conduct a thorough analysis and implement appropriate measures to correct adverse changes. The financial management of the companies surveyed had worked towards improving the state of the enterprise, thereby seeking to reduce liquidity risk.

  16. Current peripheral bypass surgery: various clinical studies

    NARCIS (Netherlands)

    Slaa, Alexander te

    2011-01-01

    Substantial post-operative edema occurs in the majority of patients who undergo peripheral bypass surgery due to severe peripheral arterial disease (PAD). The pathophysiological mechanisms that underlay edema formation following peripheral bypass surgery include hyperemia, an increased capillary per

  17. Current peripheral bypass surgery: various clinical studies

    NARCIS (Netherlands)

    Slaa, Alexander te

    2011-01-01

    Substantial post-operative edema occurs in the majority of patients who undergo peripheral bypass surgery due to severe peripheral arterial disease (PAD). The pathophysiological mechanisms that underlay edema formation following peripheral bypass surgery include hyperemia, an increased capillary per

  18. Current Research on Chinese Students Studying Abroad

    Science.gov (United States)

    Henze, Jurgen; Zhu, Jiani

    2012-01-01

    As a result of China's growing participation and importance in the process of internationalization and globalization a continuously rising number of Chinese students has gone abroad for further study. By the end of the last decade the number of Chinese students abroad made up the largest group of international students in the USA (surpassing those…

  19. Current Research on Chinese Students Studying Abroad

    Science.gov (United States)

    Henze, Jurgen; Zhu, Jiani

    2012-01-01

    As a result of China's growing participation and importance in the process of internationalization and globalization a continuously rising number of Chinese students has gone abroad for further study. By the end of the last decade the number of Chinese students abroad made up the largest group of international students in the USA (surpassing those…

  20. Tobin Tax: Arguments and Current Derivative Studies

    Directory of Open Access Journals (Sweden)

    Ozekicioglu Seda

    2015-04-01

    Full Text Available Tobin Tax and its derivative applications have started to be discussed again in many platforms as the issue regarding taxation of short-term capital movements has become an agenda among international communities such as European Union (EU and G20 since the beginning of 2000s. In this study, Tobin Tax, which is the first significant step towards taxation of foreign currency transactions, has been discussed theoretically and considering its possible effects on application. Also, in this context, the initiatives of countries such as USA, Belgium, France and Austria regarding international implementation of Tobin Tax and its derivatives are being evaluated. The intended use of the taxes, determination of transactions exempt from tax and international cooperation in the implementation of taxation are possible problems that can be faced regarding Tobin Tax. In this study the conclusion, which the effects of Tobin Tax in developing and developed countries will be different but imposing such tax regarding cyclic balance of the world economy will be a positive improvement, has been reached.

  1. Ocular biomechanics study: current state and perspectives

    Directory of Open Access Journals (Sweden)

    S. Yu. Petrov

    2015-03-01

    Full Text Available Despite the fact that the eye represents a challenge for biomechanical research due to its size, over the last two decades, much data on ocular biomechanics were accumulated. Scleral and lamina cribrosa biomechanics contribute to our understanding of myopia and open-angle glaucoma; iris and trabecular meshwork biomechanics to that of angle-closure glaucoma; vitreous biomechanics to that of retinal detachment and ocular drug delivery; corneal biomechanics to that of keratoconus; and lens capsule biomechanics to that of cataract. This paper offers a general overview of recent advances in corneal, scleral, crystalline lens, and lamina cribrosa biomechanics and summarizes the results of experimental and clinical studies. Ocular biomechanics abnormalities affect etiology of many eye diseases. Ocular biomechanics plays an important role in the development of novel diagnostic methods, therapeutic and surgical procedures. Corneal biomechanics impacts etiology and pathogenesis of keratoconus as well as tonometry accuracy and explains corneal refractive surgery effect. Scleral biomechanics is associated with IOP and progressive myopia. Accommodative apparatus (ciliary body and crystalline lens is an important anatomic physiological structure. Recent studies uncovered the causes of agerelated loss of accommodation as a result of lens involution. Optic nerve head abnormalities due to IOP fluctuations are the key factor of glaucomatous neuropathy. They are directly associated with ocular biomechanics as well.

  2. Ocular biomechanics study: current state and perspectives

    Directory of Open Access Journals (Sweden)

    S. Yu. Petrov

    2015-01-01

    Full Text Available Despite the fact that the eye represents a challenge for biomechanical research due to its size, over the last two decades, much data on ocular biomechanics were accumulated. Scleral and lamina cribrosa biomechanics contribute to our understanding of myopia and open-angle glaucoma; iris and trabecular meshwork biomechanics to that of angle-closure glaucoma; vitreous biomechanics to that of retinal detachment and ocular drug delivery; corneal biomechanics to that of keratoconus; and lens capsule biomechanics to that of cataract. This paper offers a general overview of recent advances in corneal, scleral, crystalline lens, and lamina cribrosa biomechanics and summarizes the results of experimental and clinical studies. Ocular biomechanics abnormalities affect etiology of many eye diseases. Ocular biomechanics plays an important role in the development of novel diagnostic methods, therapeutic and surgical procedures. Corneal biomechanics impacts etiology and pathogenesis of keratoconus as well as tonometry accuracy and explains corneal refractive surgery effect. Scleral biomechanics is associated with IOP and progressive myopia. Accommodative apparatus (ciliary body and crystalline lens is an important anatomic physiological structure. Recent studies uncovered the causes of agerelated loss of accommodation as a result of lens involution. Optic nerve head abnormalities due to IOP fluctuations are the key factor of glaucomatous neuropathy. They are directly associated with ocular biomechanics as well.

  3. Study of high current commutation by explosive switch

    Science.gov (United States)

    Usuba, S.; Kakudate, Y.; Yoshida, M.; Fujiwara, S.; Miyamoto, M.; Morita, T.; Kubota, A.; den, M.

    1993-01-01

    The study presents the basic experimental data obtained with a large current opening switch for current commutation using explosives. It is shown that currents up to a maximum of 40 kA can be completely interrupted within 30 microsec. The mechanism of current interruption using a thin conductor plate and methods of measuring interrupting current with a pickup coil and taking photographs with a high-speed camera (one frame per microsec) are discussed.

  4. High-performance control of a three-phase voltage-source converter including feedforward compensation of the estimated load current

    Energy Technology Data Exchange (ETDEWEB)

    Leon, Andres E.; Solsona, Jorge A.; Busada, Claudio; Chiacchiarini, Hector [Instituto de Investigaciones en Ingenieria Electrica (IIIE) UNS-CONICET, Universidad Nacional del Sur, Av. Alem 1253, Bahia Blanca 8000 (Argentina); Valla, Maria Ines [Laboratorio de Electronica Industrial, Control e Instrumentacion (LEICI) and CONICET, Facultad de Ingenieria, Universidad Nacional de La Plata, La Plata 1900 (Argentina)

    2009-08-15

    In this paper a new control strategy for voltage-source converters (VSC) is introduced. The proposed strategy consists of a nonlinear feedback controller based on feedback linearization plus a feedforward compensation of the estimated load current. In our proposal an energy function and the direct-axis current are considered as outputs, in order to avoid the internal dynamics. In this way, a full linearization is obtained via nonlinear transformation and feedback. An estimate of the load current is feedforwarded to improve the performance of the whole system and to diminish the capacitor size. This estimation allows to obtain a more rugged and cheaper implementation. The estimate is calculated by using a nonlinear reduced-order observer. The proposal is validated through different tests. These tests include performance in presence of switching frequency, measurement filters delays, parameters uncertainties and disturbances in the input voltage. (author)

  5. Detailed magnetic model simulations of the H- injection chicane magnets for the CERN PS Booster Upgrade, including eddy currents and influence on beam dynamics

    CERN Document Server

    Benedetto, E; Borburgh, J; Carli, C; Martini, M; Forte, V

    2014-01-01

    The CERN PS Booster will be upgraded with an H- injection system. The chicanemagnets for the injection bump ramp-down in 5 ms and generate eddy currents in the inconel vacuum chamber which perturb the homogeneity of the magnetic field. The multipolar field components are extracted from 3D OPERA simulations and are included in the lattice model. The -beating correction is computed all along the ramp and complete tracking simulations including space-charge are performed to evaluate the impact of these perturbations and correction on beam dynamics.

  6. Current Mathematical Methods Used in QSAR/QSPR Studies

    Directory of Open Access Journals (Sweden)

    Peixun Liu

    2009-04-01

    Full Text Available This paper gives an overview of the mathematical methods currently used in quantitative structure-activity/property relationship (QASR/QSPR studies. Recently, the mathematical methods applied to the regression of QASR/QSPR models are developing very fast, and new methods, such as Gene Expression Programming (GEP, Project Pursuit Regression (PPR and Local Lazy Regression (LLR have appeared on the QASR/QSPR stage. At the same time, the earlier methods, including Multiple Linear Regression (MLR, Partial Least Squares (PLS, Neural Networks (NN, Support Vector Machine (SVM and so on, are being upgraded to improve their performance in QASR/QSPR studies. These new and upgraded methods and algorithms are described in detail, and their advantages and disadvantages are evaluated and discussed, to show their application potential in QASR/QSPR studies in the future.

  7. [Characteristics and cardiovascular events in a general population included in the RICARTO (RIesgo CARdiovascular TOledo) study: Data from the first 1,500 individuals included in the study].

    Science.gov (United States)

    Rodríguez-Roca, G C; Segura-Fragoso, A; Villarín-Castro, A; Alonso-Moreno, F J; Rodríguez-Padial, L; Rodríguez-García, M L; Fernández-Conde, J A; Rojas-Martelo, G A; Menchén-Herreros, A; Escobar-Cervantes, C; Fernández-Martín, J; Artigao-Rodenas, L M; Carbayo-Herencia, J A; Hernández-Moreno, J

    2017-08-28

    The aim of this study was to assess cardiovascular risk (CVR) by investigating the prevalence of CVR factors (CVRF), target organ damage (TOD), and cardiovascular disease (CVD) in general population of the health area of Toledo, Spain. Epidemiological and observational study that analysed a sample from the general population aged 18years or older, randomly selected from a database of health cards stratified by age and gender. Clinical history, physical examination, and complementary tests were performed. Total blood and serum samples were frozen at -85°C to evaluate genetic studies in the future. Standard statistical analysis was performed. CVR was assessed by the SCORE scale calibrated for the Spanish population, and the Framingham Heart Study scale. A total of 1,500 individuals (mean age 49.1±15.8years, 55.6% women) were included. Prevalences: dyslipidaemia 56.9% (95% confidence interval [95% CI]: 54.3-59.4), hypertension 33.0% (95%CI: 30.6-35.4), diabetes mellitus 8.6% (95%CI: 7.17-10.1), smoking 24.2% (95%CI; 122.0-26.4), obesity 25.3% (95%CI; 23.1-27.5), and sedentary life-style 39.4% (95%CI; 36.9-41.8). No CVRF was reported in 21.1% of cases, and 18.6% had 3-5 CVRF. TOD: electrocardiographic left ventricular hypertrophy, 4.3%, peripheral artery disease, 10.1% (Doppler ultrasound), and 15.3% (oscillometric device), microalbuminuria, 4.3%, sub-clinical renal disease, 3.2%, and nephropathy in 3.8% (CKD-EPI). At least one CVD was reported in 9.2% of cases. A low CVR (SCORE) was present in 44.6% of individuals. Dyslipidaemia was found in 60% of individuals, 40% had a sedentary life-style, 30% with hypertension, 20% smoked, 20% obesity, and almost 10% with diabetes. More than a half of individuals have a moderate-high-very high risk. The prevalence of TOD and CVD are significant. Copyright © 2017 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  8. Dynamic modeling of slow-light in a semiconductor optical amplifier including the effects of forced coherent population oscillations by bias current modulation

    Science.gov (United States)

    Connelly, M. J.

    2014-05-01

    The slow light effect in SOAs has many applications in microwave photonics such as phase shifting and filtering. Models are needed to predict slow light in SOAs and its dependence on the bias current, optical power and modulation index. In this paper we predict the slow light characteristics of a tensile-strained SOA by using a detailed time-domain model. The model includes full band-structure based calculations of the material gain, bimolecular recombination and spontaneous emission, a carrier density rate equation and travelling wave equations for the input signal and amplified spontaneous emission. The slow light effect is caused by coherent population oscillations, whereby beating between the spectral components of an amplitude modulated lightwave causes carrier density oscillations at the beat frequency, leading to changes in the group velocity. The resulting beat signal at the SOA output after photodetection, is phase shifted relative to the SOA input beat signal. The phase shift can be adjusted by controlling the optical power and bias current. However the beat signal gain is low at low frequencies, leading to a poor beat signal output signal-to-noise ratio. If the optical input and SOA drive current are simultaneously modulated, this leads to forced population oscillations that greatly enhance the low frequency beat signal gain. The model is used to determine the improvement in gain and phase response and its dependency on the optical power, bias current and modulation index. Model predictions show good agreement with experimental trends reported in the literature.

  9. Including non-public data and studies in systematic reviews and systematic maps.

    Science.gov (United States)

    Haddaway, Neal R; Collins, Alexandra M; Coughlin, Deborah; Kohl, Christian

    2017-02-01

    Systematic reviews and maps should be based on the best available evidence, and reviewers should make all reasonable efforts to source and include potentially relevant studies. However, reviewers may not be able to consider all existing evidence, since some data and studies may not be publicly available. Including non-public studies in reviews provides a valuable opportunity to increase systematic review/map comprehensiveness, potentially mitigating negative impacts of publication bias. Studies may be non-public for many reasons: some may still be in the process of being published (publication can take a long time); some may not be published due to author/publisher restrictions; publication bias may make it difficult to publish non-significant or negative results. Here, we consider what forms these non-public studies may take and the implications of including them in systematic reviews and maps. Reviewers should carefully consider the advantages and disadvantages of including non-public studies, weighing risks of bias against benefits of increased comprehensiveness. As with all systematic reviews and maps, reviewers must be transparent about methods used to obtain data and avoid risks of bias in their synthesis. We make tentative suggestions for reviewers in situations where non-public data may be present in an evidence base.

  10. Meta-analyses including non-randomized studies of therapeutic interventions: a methodological review

    Directory of Open Access Journals (Sweden)

    Timor Faber

    2016-03-01

    Full Text Available Abstract Background There is an increasing number of meta-analyses including data from non-randomized studies for therapeutic evaluation. We aimed to systematically assess the methods used in meta-analyses including non-randomized studies evaluating therapeutic interventions. Methods For this methodological review, we searched MEDLINE via PubMed, from January 1, 2013 to December 31, 2013 for meta-analyses including at least one non-randomized study evaluating therapeutic interventions. Etiological assessments and meta-analyses with no comparison group were excluded. Two reviewers independently assessed the general characteristics and key methodological components of the systematic review process and meta-analysis methods. Results One hundred eighty eight meta-analyses were selected: 119 included both randomized controlled trials (RCTs and non-randomized studies of interventions (NRSI and 69 only NRSI. Half of the meta-analyses (n = 92, 49 % evaluated non-pharmacological interventions. “Grey literature” was searched for 72 meta-analyses (38 %. An assessment of methodological quality or risk of bias was reported in 135 meta-analyses (72 % but this assessment considered the risk of confounding bias in only 33 meta-analyses (18 %. In 130 meta-analyses (69 %, the design of each NRSI was not clearly specified. In 131 (70 %, whether crude or adjusted estimates of treatment effect for NRSI were combined was unclear or not reported. Heterogeneity across studies was assessed in 182 meta-analyses (97 % and further explored in 157 (84 %. Reporting bias was assessed in 127 (68 %. Conclusions Some key methodological components of the systematic review process—search for grey literature, description of the type of NRSI included, assessment of risk of confounding bias and reporting of whether crude or adjusted estimates were combined—are not adequately carried out or reported in meta-analyses including NRSI.

  11. THE EVALUATION OF FOLK CULTURE ELEMENTS INCLUDING IN PRIMARY SCHOOL SOCIAL STUDIES TEXTBOOKS

    Directory of Open Access Journals (Sweden)

    2013-06-01

    Full Text Available Folk culture is a total of common values, behaviors and ways of living patterns produced, kept alive, transferred to the next generations orally or written, informal education and concentrating on traditional areas. There is no doubt that transferring folk culture to the next generations will contribute to the protection of national identities against globalization, an inevitable process. The way of its realization is based on education. One of the most important lessons in which folk culture can be transferred to the young generations in primary education is social studies. The aim of this research is to reveal to what extend folk culture elements were included in 4th,5th, 6th, 7th grade social studies textbooks and workbooks. At the end of the research, which was carried out with scanning model and content analysis, it was found that seasonal festivals, children's games, marriage, processing, women's clothing and dress-ornament, dining-food-beverage, Karagoz, proverbs, folk music/instrument, Turkish folk dances, wrestling, and javelin folk culture elements were mostly included in the textbooks. Since social studies is an interdisciplinary field, it was presented with samples that all the elements of folk culture can be included in social studies textbooks.

  12. How should clinical data be included in experimental studies of cancer immunology?

    Science.gov (United States)

    Gjertsen, Bjørn Tore; Bruserud, Øystein

    2004-08-01

    Patients diagnosed with the same malignant disease are often heterogeneous with regard to age, complications, malignant cell morphology and tumor histology, disease stage, prognostic parameters, and previous therapy. Many of these factors can affect immunocompetent cells or influence the malignant cell susceptibility to immunotherapy. Summaries of relevant clinical information should therefore be included in cancer immunology studies to increase the present as well as the future scientific impact. Guidelines for selection of relevant information are suggested in the article.

  13. Relativistic study of the energy-dependent Coulomb potential including Coulomb-like tensor interaction

    CERN Document Server

    Hamzavi, Majid

    2012-01-01

    The exact Dirac equation for the energy-dependent Coulomb (EDC) potential including a Coulomb-like tensor (CLT) potential has been studied in the presence of spin and pseudospin (p-spin) symmetries with arbitrary spin-orbit quantum number The energy eigenvalues and corresponding eigenfunctions are obtained in the framework of asymptotic iteration method (AIM). Some numerical results are obtained in the presence and absence of EDC and CLT potentials.

  14. Simulation studies of direct-current microdischarges for electric propulsion

    Science.gov (United States)

    Deconinck, Thomas Dominique

    The structure of direct-current microdischarges is investigated using a detailed two-dimensional multi-species continuum model. Microdischarges are direct-current discharges that operate at a relatively high pressure of about 100 Torr and geometric dimensions in the 10-100 micrometer range. Our motivation for the study of microdischarges comes from a potential application of these devices in microthrusters for small satellite propulsion. The Micro Plasma Thruster (MPT) concept consists of a direct-current microdischarge in a geometry comprising a constant area flow section followed by a diverging exit nozzle. A detailed description of the plasma dynamics inside the MPT including power deposition, ionization, coupling of the plasma phenomena with high-speed flow, and propulsion system performance is reported in this study. A two-dimensional model is developed as part of this study. The model consists of a plasma module coupled to a flow module and is solved on a hybrid unstructured mesh framework. The plasma module provides a self-consistent, multi-species, multi-temperature description of the microdischarge phenomena while the flow module provides a description of the low Reynolds number compressible flow through the system. The plasma module solves conservation equations for plasma species continuity and electron energy, and Poisson's equation for the self-consistent electric field. The flow module solves mass, bulk gas momentum and energy equations. The coupling of energy from the electrostatic field to the plasma species is modeled by the Joule heating term which appears in the electron and heavy species energy equations. Discretization of the Joule heating term on unstructured meshes requires special attention. We propose a new robust method for the numerical discretization of the Joule heating term on such meshes using a cell-centered, finite volume approach. A prototypical microhollow cathode discharge (MHCD) is studied to guide and validate the modeling

  15. Acupuncture for neurological disorders in the Cochrane reviews:Characteristics of included reviews and studies

    Institute of Scientific and Technical Information of China (English)

    Deren Wang; Weimin Yang; Ming Liu

    2011-01-01

    OBJECTIVE: To summarize Cochrane reviews of acupuncture for neurological disorders, and characteristics of included reviews and studies.DATA SOURCES: A computer-based online search of the Cochrane Library (Issue 7 of 12, July 2010) was performed with the key word "acupuncture" and systematic evaluations for acupuncture for neurological disorders were screened.STUDY SELECTION: Systematic reviews on acupuncture in the treatment of neurological disorders were included, and the characteristics of these reviews were analyzed based on methods recommended by the Cochrane collaboration.MAIN OUTCOME MEASURES: Basic characteristics, methodological quality, main reasons for excluding trials, results and conclusions of Cochrane reviews were assessed.RESULTS: A total of 18 Cochrane systematic reviews were included, including 13 completed reviews and five research protocols. The 13 completed reviews involved 111 randomized controlled trials, including 43 trials (38.7%) conducted in China, 47 trials (42.3%) using sham-acupuncture or placebo as control, 15 trials (13.5%) with relatively high quality, 91 trials (81.9%) reporting data on follow-up. Primary outcomes used in the Cochrane reviews were reported by 65 trials (58.6%), and adverse events were reported in 11 trials (9.9%). Two hundred and eighty three trials were excluded. Two reviews on headache suggested that acupuncture is a valuable non-drug treatment for patients with chronic or recurrent headache, and has better curative effects on migraine compared with preventative drug treatment. CONCLUSION: Of the Cochrane reviews on acupuncture in the treatment of neurological disorders, two reviews evaluating the efficacy of acupuncture in treating headaches drew positive conculsions, while other reviews did not obtain positive conclusions due to a small sample size or low methodological quality. The methodological quality of acupuncture trials needs further improvement.

  16. Study of a fibre optics current sensor for the measurement of plasma current in ITER

    Science.gov (United States)

    Wuilpart, Marc; Vanus, Benoit; Andrasan, Alina; Gusarov, Andrei; Moreau, Philippe; Mégret, Patrice

    2016-05-01

    In this article, we study the feasibility of using a fibre-optics current sensor (FOCS) for the measurement of plasma current in the future fusion reactor ITER. The sensor is based on a classical FOCS interrogator involving the measurement of the state of polarization rotation undergone by the light in presence of a magnetic field (Faraday effect) in an optical fibre surrounding the current and terminated by a Faraday mirror. We considered a uniformly spun optical fibre as the sensing element and we used the Stokes formalism to simulate the sensor. The objective of the simulations is to quantify the ratio LB/SP (beat length over the spun period of the spun fibre) enabling a measurement error in agreement with the ITER specifications. The simulator takes into account the temperature variations undergone by the measurement system under ITER operation. The simulation work showed that a LB/SP ratio of 19.2 is adequate.

  17. Study of Power Flow Algorithm of AC/DC Distribution System including VSC-MTDC

    Directory of Open Access Journals (Sweden)

    Haifeng Liang

    2015-08-01

    Full Text Available In recent years, distributed generation and a large number of sensitive AC and DC loads have been connected to distribution networks, which introduce a series of challenges to distribution network operators (DNOs. In addition, the advantages of DC distribution networks, such as the energy conservation and emission reduction, mean that the voltage source converter based multi-terminal direct current (VSC-MTDC for AC/DC distribution systems demonstrates a great potential, hence drawing growing research interest. In this paper, considering losses of the reactor, the filter and the converter, a mathematical model of VSC-HVDC for the load flow analysis is derived. An AC/DC distribution network architecture has been built, based on which the differences in modified equations of the VSC-MTDC-based network under different control modes are analyzed. In addition, corresponding interface functions under five control modes are provided, and a back/forward iterative algorithm which is applied to power flow calculation of the AC/DC distribution system including VSC-MTDC is proposed. Finally, by calculating the power flow of the modified IEEE14 AC/DC distribution network, the efficiency and validity of the model and algorithm are evaluated. With various distributed generations connected to the network at appropriate locations, power flow results show that network losses and utilization of transmission networks are effectively reduced.

  18. Experimental study of the dynamics of a thin current sheet

    Science.gov (United States)

    Gekelman, W.; DeHaas, T.; Van Compernolle, B.; Daughton, W.; Pribyl, P.; Vincena, S.; Hong, D.

    2016-05-01

    Many plasmas in natural settings or in laboratory experiments carry currents. In magnetized plasmas the currents can be narrow field-aligned filaments as small as the electron inertial length ≤ft(\\tfrac{c}{{ω }pe}\\right) in the transverse dimension or fill the entire plasma column. Currents can take the form of sheets, again with the transverse dimension the narrow one. Are laminar sheets of electric current in a magnetized plasma stable? This became an important issue in the 1960s when current-carrying plasmas became key in the quest for thermonuclear fusion. The subject is still under study today. The conditions necessary for the onset for tearing are known, the key issue is that of the final state. Is there a final state? One possibility is a collection of stable tubes of current. On the other hand, is the interaction between the current filaments which are the byproduct endless, or does it go on to become chaotic? The subject of three-dimensional current systems is intriguing, rich in a variety of phenomena on multiple scale sizes and frequencies, and relevant to fusion studies, solar physics, space plasmas and astrophysical phenomena. In this study a long (δz = 11 m) and narrow (δx = 1 cm, δy = 20 cm) current sheet is generated in a background magnetoplasma capable of supporting Alfvén waves. The current is observed to rapidly tear into a series of magnetic islands when viewed in a cross-sectional plane, but they are in essence three-dimensional flux ropes. At the onset of the current, magnetic field line reconnection is observed between the flux ropes. The sheet on the whole is kink-unstable, and after kinking exhibits large-scale, low-frequency (f ≪ f ci ) rotation about the background field with an amplitude that grows with distance from the source of the current. Three-dimensional data of the magnetic and electric fields is acquired throughout the duration of the experiment and the parallel resistivity is derived from it. The parallel

  19. Modelling of transitions between L- and H-mode in JET high plasma current plasmas and application to ITER scenarios including tungsten behaviour

    Science.gov (United States)

    Koechl, F.; Loarte, A.; Parail, V.; Belo, P.; Brix, M.; Corrigan, G.; Harting, D.; Koskela, T.; Kukushkin, A. S.; Polevoi, A. R.; Romanelli, M.; Saibene, G.; Sartori, R.; Eich, T.; Contributors, JET

    2017-08-01

    The dynamics for the transition from L-mode to a stationary high Q DT H-mode regime in ITER is expected to be qualitatively different to present experiments. Differences may be caused by a low fuelling efficiency of recycling neutrals, that influence the post transition plasma density evolution on the one hand. On the other hand, the effect of the plasma density evolution itself both on the alpha heating power and the edge power flow required to sustain the H-mode confinement itself needs to be considered. This paper presents results of modelling studies of the transition to stationary high Q DT H-mode regime in ITER with the JINTRAC suite of codes, which include optimisation of the plasma density evolution to ensure a robust achievement of high Q DT regimes in ITER on the one hand and the avoidance of tungsten accumulation in this transient phase on the other hand. As a first step, the JINTRAC integrated models have been validated in fully predictive simulations (excluding core momentum transport which is prescribed) against core, pedestal and divertor plasma measurements in JET C-wall experiments for the transition from L-mode to stationary H-mode in partially ITER relevant conditions (highest achievable current and power, H 98,y ~ 1.0, low collisionality, comparable evolution in P net/P L-H, but different ρ *, T i/T e, Mach number and plasma composition compared to ITER expectations). The selection of transport models (core: NCLASS  +  Bohm/gyroBohm in L-mode/GLF23 in H-mode) was determined by a trade-off between model complexity and efficiency. Good agreement between code predictions and measured plasma parameters is obtained if anomalous heat and particle transport in the edge transport barrier are assumed to be reduced at different rates with increasing edge power flow normalised to the H-mode threshold; in particular the increase in edge plasma density is dominated by this edge transport reduction as the calculated neutral influx across the

  20. A Study of Factors Promoting Success in Computer Science Including Gender Differences

    Science.gov (United States)

    Cantwell Wilson, Brenda

    2002-03-01

    This study was conducted to determine factors that promote success in an introductory college computer science course and to determine what, if any, differences appear between genders on those factors. The model included math background, attribution for success/failure, self-efficacy, encouragement, comfort level in the course, work style preference, previous programming experience, previous non-programming computer experience, and gender as possible predictive factors for success in the computer science course. Subjects included 105 students enrolled in an introductory computer science course. The study revealed three predictive factors in the following order of importance: comfort level (with a positive influence), math background (with a positive influence), and attribution to luck (with a negative influence). No significant gender differences were found in these three factors. The study also revealed that both a formal class in programming (which had a positive correlation) and game playing (which had a negative correlation) were predictive of success. The study revealed a significant gender difference in game playing with males reporting more experience with playing games on the computer than females reported.

  1. Workplace aggression, including bullying in nursing and midwifery: a descriptive survey (the SWAB study).

    Science.gov (United States)

    Farrell, Gerald A; Shafiei, Touran

    2012-11-01

    Workplace aggression remains an important source of distress among nurses and midwives and has negative effects on staff health, patient care and organisations' reputation and fiscal health. To report on the nature and extent of workplace aggression, including bullying experienced by nurses and midwives in Victoria, Australia. A descriptive study design was chosen. The Nurses Board of Victoria posted 5000 surveys to the randomly selected registered nurses and midwives in Victoria, Australia, in 2010. The participants were asked about their experiences of violence (from clients) and bullying (from colleagues) within their most recent four working weeks. In addition, the study investigated staff actions following incidents, staff training and safety at work, and what staff believe contribute to incidents. Data analysis involved descriptive statistics, including frequencies and percentages. Chi square tests and P value were used to assess differences in categorical data. 1495 returned questionnaires were included in the study (30% response rate). Over half of the participants (52%) experienced some form of workplace aggression. Thirty-six percent experienced violence mostly from patients or their visitors/relatives and 32% experienced bullying mostly from colleagues or from their managers/supervisors. Significant differences were found between those who experienced aggression from patients and those who were bullied in respect to handling of incidents; factors thought to contribute to incidents; and organisations' handling of incidents. The study suggests that staff are less worried by patient initiated aggression compared to bullying from colleagues. For all types of aggression, respondents clearly wanted better/more realistic training, as well as enforcement of policies and support when incidents arise. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. Consumption of peptide-included and free tryptophan induced by peroxyl radicals: A kinetic study.

    Science.gov (United States)

    Fuentes, E; López-Alarcón, C

    2014-10-01

    It is well-known that tryptophan residues are efficiently oxidized by peroxyl radicals, generating kynurenine, and N-formyl kynurenine as well as hydroperoxide derivatives as products. In the present work we studied the kinetic of such reaction employing free and peptide-included tryptophan. Two azocompounds were used to produce peroxyl radicals: AAPH (2,2'-Azobis(2-methylpropionamidine) dihydrochloride) and ABCVA (4,4'-Azobis(4-cyanovaleric acid)), which generate cationic and anionic peroxyl radicals, respectively. Tryptophan consumption was assessed by fluorescence spectroscopy and the reactions were carried out in phosphate buffer (75mM, pH 7.4) at 45°C. Only a slight effect of the peroxyl radical charge was evidenced on the consumption of free tryptophan and the dipeptide Gly-Trp. Employing AAPH as peroxyl radical source, at low free tryptophan concentrations (1-10µM) near 0.3 mol of tryptophan were consumed per each mol of peroxyl radicals introduced into the system. However, at high free tryptophan concentrations (100µM-1mM) such stoichiometry increased in a tryptophan concentration-way. At 1mM three moles of tryptophan were consumed per mol of AAPH-derived peroxyl radicals, evidencing the presence of chain reactions. A similar behavior was observed when di and tri-peptides (Gly-Trp, Trp-Gly, Gly-Trp-Gly, Trp-Ala, Ala-Trp-Ala) were studied. Nonetheless, at low initial concentration (5µM), the initial consumption rate of tryptophan included in the peptides was two times higher than free tryptophan. In contrast, at high concentration (1mM) free and peptide-included tryptophan showed similar initial consumption rates. These results could be explained considering a disproportionation process of tryptophanyl radicals at low free tryptophan concentrations, a process that would be inhibited when tryptophan is included in peptides.

  3. Measuring Outcomes in Adult Weight Loss Studies That Include Diet and Physical Activity: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Rachel A. Millstein

    2014-01-01

    Full Text Available Background. Measuring success of obesity interventions is critical. Several methods measure weight loss outcomes but there is no consensus on best practices. This systematic review evaluates relevant outcomes (weight loss, BMI, % body fat, and fat mass to determine which might be the best indicator(s of success. Methods. Eligible articles described adult weight loss interventions that included diet and physical activity and a measure of weight or BMI change and body composition change. Results. 28 full-text articles met inclusion criteria. Subjects, settings, intervention lengths, and intensities varied. All studies measured body weight (−2.9 to −17.3 kg, 9 studies measured BMI (−1.1 to −5.1 kg/m2, 20 studies measured % body fat (−0.7 to −10.2%, and 22 studies measured fat mass (−0.9 to −14.9 kg. All studies found agreement between weight or BMI and body fat mass or body fat % decreases, though there were discrepancies in degree of significance between measures. Conclusions. Nearly all weight or BMI and body composition measures agreed. Since body fat is the most metabolically harmful tissue type, it may be a more meaningful measure of health change. Future studies should consider primarily measuring % body fat, rather than or in addition to weight or BMI.

  4. Comprehensive study in the inhibitory effect of berberine on gene transcription, including TATA box.

    Directory of Open Access Journals (Sweden)

    Yugang Wang

    Full Text Available Berberine (BBR is an established natural DNA intercalator with numerous pharmacological functions. However, currently there are neither detailed reports concerning the distribution of this alkaloid in living cells nor reports concerning the relationship between BBR's association with DNA and the function of DNA. Here we report that the distribution of BBR within the nucleus can be observed 30 minutes after drug administration, and that the content of berberine in the nucleus peaks at around 4 µmol, which is twelve hours after drug administration. The spatial conformation of DNA and chromatin was altered immediately after their association with BBR. Moreover, this association can effectively suppress the transcription of DNA in living cell systems and cell-free systems. Electrophoretic mobility shift assays (EMSA demonstrated further that BBR can inhibit the association between the TATA binding protein (TBP and the TATA box in the promoter, and this finding was also attained in living cells by chromatin immunoprecipitation (ChIP. Based on results from this study, we hypothesize that berberine can suppress the transcription of DNA in living cell systems, especially suppressing the association between TBP and the TATA box by binding with DNA and, thus, inhibiting TATA box-dependent gene expression in a non-specific way. This novel study has significantly expanded the sphere of knowledge concerning berberine's pharmacological effects, beginning at its paramount initial interaction with the TATA box.

  5. Current Advances in the Metabolomics Study on Lotus Seeds.

    Science.gov (United States)

    Zhu, Mingzhi; Liu, Ting; Guo, Mingquan

    2016-01-01

    Lotus (Nelumbo nucifera), which is distributed widely throughout Asia, Australia and North America, is an aquatic perennial that has been cultivated for over 2,000 years. It is very stimulating that almost all parts of lotus have been consumed as vegetable as well as food, especially the seeds. Except for the nutritive values of lotus, there has been increasing interest in its potential as functional food due to its rich secondary metabolites, such as flavonoids and alkaloids. Not only have these metabolites greatly contributed to the biological process of lotus seeds, but also have been reported to possess multiple health-promoting effects, including antioxidant, anti-amnesic, anti-inflammatory, and anti-tumor activities. Thus, comprehensive metabolomic profiling of these metabolites is of key importance to help understand their biological activities, and other chemical biology features. In this context, this review will provide an update on the current technological platforms, and workflow associated with metabolomic studies on lotus seeds, as well as insights into the application of metabolomics for the improvement of food safety and quality, assisting breeding, and promotion of the study of metabolism and pharmacokinetics of lotus seeds; meanwhile it will also help explore new perspectives and outline future challenges in this fast-growing research subject.

  6. Solar cycle in current reanalyses: (nonlinear attribution study

    Directory of Open Access Journals (Sweden)

    A. Kuchar

    2014-12-01

    Full Text Available This study focusses on the variability of temperature, ozone and circulation characteristics in the stratosphere and lower mesosphere with regard to the influence of the 11 year solar cycle. It is based on attribution analysis using multiple nonlinear techniques (Support Vector Regression, Neural Networks besides the traditional linear approach. The analysis was applied to several current reanalysis datasets for the 1979–2013 period, including MERRA, ERA-Interim and JRA-55, with the aim to compare how this type of data resolves especially the double-peaked solar response in temperature and ozone variables and the consequent changes induced by these anomalies. Equatorial temperature signals in the lower and upper stratosphere were found to be sufficiently robust and in qualitative agreement with previous observational studies. The analysis also pointed to the solar signal in the ozone datasets (i.e. MERRA and ERA-Interim not being consistent with the observed double-peaked ozone anomaly extracted from satellite measurements. Consequently the results obtained by linear regression were confirmed by the nonlinear approach through all datasets, suggesting that linear regression is a relevant tool to sufficiently resolve the solar signal in the middle atmosphere. Furthermore, the seasonal dependence of the solar response was also discussed, mainly as a source of dynamical causalities in the wave propagation characteristics in the zonal wind and the induced meridional circulation in the winter hemispheres. The hypothetical mechanism of a weaker Brewer Dobson circulation was reviewed together with discussion of polar vortex stability.

  7. Solar cycle in current reanalyses: (non)linear attribution study

    Science.gov (United States)

    Kuchar, A.; Sacha, P.; Miksovsky, J.; Pisoft, P.

    2014-12-01

    This study focusses on the variability of temperature, ozone and circulation characteristics in the stratosphere and lower mesosphere with regard to the influence of the 11 year solar cycle. It is based on attribution analysis using multiple nonlinear techniques (Support Vector Regression, Neural Networks) besides the traditional linear approach. The analysis was applied to several current reanalysis datasets for the 1979-2013 period, including MERRA, ERA-Interim and JRA-55, with the aim to compare how this type of data resolves especially the double-peaked solar response in temperature and ozone variables and the consequent changes induced by these anomalies. Equatorial temperature signals in the lower and upper stratosphere were found to be sufficiently robust and in qualitative agreement with previous observational studies. The analysis also pointed to the solar signal in the ozone datasets (i.e. MERRA and ERA-Interim) not being consistent with the observed double-peaked ozone anomaly extracted from satellite measurements. Consequently the results obtained by linear regression were confirmed by the nonlinear approach through all datasets, suggesting that linear regression is a relevant tool to sufficiently resolve the solar signal in the middle atmosphere. Furthermore, the seasonal dependence of the solar response was also discussed, mainly as a source of dynamical causalities in the wave propagation characteristics in the zonal wind and the induced meridional circulation in the winter hemispheres. The hypothetical mechanism of a weaker Brewer Dobson circulation was reviewed together with discussion of polar vortex stability.

  8. The value of including spirometry in health checks - a randomized controlled study in primary health care

    DEFF Research Database (Denmark)

    Ørts, Lene Maria; Ottesen, Anders Løkke; Bjerregaard, Anne-Louise

    studies in the Ph.D. project will evaluate whether early spirometry measurements can be used to predict future lung disease and describe the follow up of patients with abnormal spirometry measurements at the general practitioner. Disclosure of interest: None to declare. Key words: early spirometry......Background Lung diseases are among the most frequent and most serious ailments in Denmark. Preventive health checks including spirometry can be used to detect lung diseases earlier. Over time the attendance at preventive health checks has decreased and at present the response rate is approximately...... 50%. Little is known about initiatives that can influence the attendance rate. Objectives To examine whether focused information on spirometry in the invitation material will influence the attendance in preventive health checks. Materiel/Methods Design: A randomized controlled study on information...

  9. Evolution of the Coronal Magnetic Configurations Including a Current-Carrying Flux Rope in Response to the Change in the Background Field

    CERN Document Server

    Wang, Hong-Juan; Gong, Jian-Cun; Lin, Jun

    2014-01-01

    We investigate equilibrium height of the flux rope, and its internal equilibrium in a realistic plasma environment by carrying out numerical simulations of the evolution of systems including a current-carrying flux rope. We find that the equilibrium height of the flux rope is approximately a power-law function of the relative strength of the background field. Our simulations indicate that the flux rope can escape more easily from a weaker background field. This further confirms the catastrophe in the magnetic configuration of interest can be triggered by decrease of strength of the background field. Our results show that it takes some time to reach internal equilibrium depending on the initial state of the flux rope. The plasma flow inside the flux rope due to the adjustment for the internal equilibrium of the flux rope remains small and does not last very long when the initial state of the flux rope commences from the stable branch of the theoretical equilibrium curve. This work also confirms the influence o...

  10. Study on Fault Current of DFIG during Slight Fault Condition

    OpenAIRE

    Xiangping Kong; Zhe Zhang; Xianggen Yin; Zhenxing Li

    2013-01-01

    In order to ensure the safety of DFIG when severe fault happens, crowbar protection is adopted. But during slight fault condition, the crowbar protection will not trip, and the DFIG is still excited by AC-DC-AC converter. In this condition, operation characteristics of the converter have large influence on the fault current characteristics of DFIG. By theoretical analysis and digital simulation, the fault current characteristics of DFIG during slight voltage dips are studied. And the influenc...

  11. Plasma-water systems studied with optical diagnostics including sum-frequency generation spectroscopy

    Science.gov (United States)

    Ito, Tsuyohito

    2016-09-01

    Recently, various applications of plasma-water systems have been reported, such as materials synthesis, agricultural applications, and medical treatments. As one of basic studies of such systems, we are investigating water surface structure influenced by a plasma via vibrational sum-frequency generation spectroscopy. Vibrational sum-frequency generation spectroscopy is known to be an interfacially active diagnostic technique, as such process occurs in noncentrosymmetric medium. Visible and wavenumber-tunable infrared beams are simultaneously irradiated to the interface. The interfacial water has ice-like ( 3200 cm-1), liquid-like ( 3400 cm-1), and free OH (3700 cm-1) structures (assignment of the ice-like structure still remains contentious), and the intensity of the signal becomes stronger when the tunable infrared beam resonates with a vibration of the structures. The results indicate that with generating air dielectric barrier discharges for supplying reactive species to the water surface, all investigated signals originating from the above-mentioned three structures decrease. Furthermore, the signal strengths are recovered after terminating the plasma generation. We currently believe that the surface density of the reactive species should be high when they are found at the water surface. Details on the experimental results of the sum-frequency generation spectroscopy, as well as other spectroscopic results of plasma-water systems, will be presented at the conference.

  12. Behavioral factors to include in guidelines for lifelong oral healthiness: an observational study in Japanese adults

    Directory of Open Access Journals (Sweden)

    Shimozato Miho

    2006-12-01

    Full Text Available Abstract Background The aim of this study was to determine which behavioral factors to include in guidelines for the Japanese public to achieve an acceptable level of oral healthiness. The objective was to determine the relationship between oral health related behaviors and symptoms related to oral disease and tooth loss in a Japanese adult community. Methods Oral health status and lifestyle were investigated in 777 people aged 20 years and older (390 men and 387 women. Subjects were asked to complete a postal questionnaire concerning past diet and lifestyle. The completed questionnaires were collected when they had health examinations. The 15 questions included their preference for sweets, how many between-meal snacks they usually had per day, smoking and drinking habits, presence of oral symptoms, and attitudes towards dental visits. Participants were asked about their behaviors at different stages of their life. The oral health examinations included examination of the oral cavity and teeth performed by dentists using WHO criteria. Odds ratios were calculated for all subjects, all 10 year age groups, and for subjects 30 years or older, 40 years or older, 50 years or older, and 60 years or older. Results Frequency of tooth brushing (OR = 3.98, having your own toothbrush (OR = 2.11, smoking (OR = 2.71 and bleeding gums (OR = 2.03 were significantly associated with number of retained teeth in males. Frequency of between-meal snacks was strongly associated with number of retained teeth in females (OR = 4.67. Having some hobbies (OR = 2.97, having a family dentist (OR = 2.34 and consulting a dentist as soon as symptoms occurred (OR = 1.74 were significantly associated with number of retained teeth in females. Factors that were significantly associated with tooth loss in both males and females included alcohol consumption (OR = 11.96, males, OR = 3.83, females, swollen gums (OR = 1.93, males, OR = 3.04, females and toothache (OR = 3.39, males, OR

  13. Precision study of ZZγ production including Z-boson leptonic decays at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yu; Duan, Peng-Fei [Kunming University of Science and Technology, City College, Kunming, Yunnan (China); Ma, Wen-Gan; Zhang, Ren-You; Chen, Chong [University of Science and Technology of China (USTC), Department of Modern Physics, Hefei, Anhui (China)

    2016-02-15

    We report on the precision predictions for the e{sup +}e{sup -} → ZZγ process including Z-boson leptonic decays at the ILC in the standard model (SM). The calculation includes the full next-to-leading (NLO) electroweak (EW) corrections and high order initial state radiation (h.o. ISR) contributions. We find that the NLO EW corrections heavily suppress the LO cross section, and the h.o. ISR effects are notable near the threshold while become small in high energy region. We present the LO and the NLO EW+h.o. ISR corrected distributions of the transverse momenta of final Z-boson and photon as well as the Z-pair invariant mass, and we investigate the corresponding NLO EW and h.o. ISR relative corrections. We also study the leptonic decays of the final Z-boson pair by adopting the MadSpin method where the spin correlation effect is involved. We conclude that both the h.o. ISR effects and the NLO EW corrections are important in exploring the ZZγ production at the ILC. (orig.)

  14. Precision study on $ZZ\\gamma$ production including $Z$-boson leptonic decays at the ILC

    CERN Document Server

    Yu, Zhang; Wen-Gan, Ma; Ren-You, Zhang; Chong, Chen

    2015-01-01

    We report on the precision predictions for the \\eezzr process including $Z$-boson leptonic decays at the ILC in the standard model (SM). The calculation includes the full next-to-leading (NLO) electroweak (EW) corrections and high order initial state radiation (h.o.ISR) contributions. We find that the NLO EW corrections heavily suppress the LO cross section, and the h.o.ISR effects are notable near the threshold while become small in high energy region. We present the LO and the NLO EW+h.o.ISR corrected distributions of the transverse momenta of final $Z$-boson and photon as well as the $Z$-pair invariant mass, and investigate the corresponding NLO EW and h.o.ISR relative corrections. We also study the leptonic decays of the final $Z$-boson pair by adopting the {\\sc MadSpin} method where the spin correlation effect is involved. We conclude that both the h.o.ISR effects and the NLO EW corrections are important in exploring the $ZZ\\gamma$ production at the ILC.

  15. Electron diffraction study of {alpha}-AlMnSi crystals including non-crystallographic axes

    Energy Technology Data Exchange (ETDEWEB)

    Song, G.L.; Bursill, L.A.

    1997-06-01

    The structure of crystalline {alpha}-AlMnSi is examined by electron diffraction. Six distinct zone axes are examined, including both normal crystallographic and non-crystallographic zones axes, allowing the space group symmetry to be studied. Electron diffraction patterns characteristic of Pm3-bar were obtained for thicker specimens. However, for very thin specimens, as used for HRTEM imaging, the electron diffraction patterns were characteristic of Im3-bar space group symmetry. The structural basis of the Pm3-bar to Im3-bar transformation may be understood in terms of an analysis of the icosahedral structural elements located at the corners and body-centers of the cubic unit cell. A method for indexing the non-crystallographic zone axis diffraction patterns is described. An electron diffraction pattern of the 5-fold axis of the quasicrystalline phase i-AlMnSi is also included; this is compared with the experimental results and calculations for the [0{tau}1] axis of Pm3-bar and Im3-bar crystalline phases. 26 refs., 4 tabs., 7 figs.

  16. Adult exposures from MDCT including multiphase studies: first Italian nationwide survey

    Energy Technology Data Exchange (ETDEWEB)

    Palorini, Federica; Origgi, Daniela [Fisica Sanitaria Istituto Europeo di Oncologia, Milan (Italy); Granata, Claudio [UOC di Radiologia Istituto Giannina Gaslini, Genoa (Italy); Matranga, Domenica [Universita degli Studi di Palermo, Dipartimento di Scienze per la Promozione della Salute e Materno-infantile ' ' G. D' Alessandro' ' , Palermo (Italy); Salerno, Sergio [Policlinico Universita di Palermo, Dipartimento di Scienze Radiologiche, Palermo (Italy)

    2014-02-15

    To evaluate the radiation dose in routine multidetector computed tomography (MDCT) examinations in Italian population. This was a retrospective multicentre study included 5,668 patients from 65 radiology departments who had undergone common CT protocols: head, chest, abdomen, chest-abdomen-pelvis (CAP), spine and cardiac. Data included patient characteristics, CT parameters, volumetric CT dose index (CTDI{sub vol}) and dose length product (DLP) for each CT acquisition phase. Descriptive statistics were calculated, and a multi-regression analysis was used to outline the main factors affecting exposure. The 75th percentiles of CTDI{sub vol} (mGy) and DLP (mGy cm) for whole head were 69 mGy and 1,312 mGy cm, respectively; for chest, 15 mGy and 569 mGy cm; spine, 42 mGy and 888 mGy cm; cardiac, 7 mGy and 131 mGy cm for calcium score, and 61 mGy and 1,208 mGy cm for angiographic CT studies. High variability was present in the DLP of abdomen and CAP protocols, where multiphase examinations dominated (71 % and 73 % respectively): for abdomen, 18 mGy, with 555 and 920 mGy cm in abdomen and abdomen-pelvis acquisitions respectively; for CAP, 17 mGy, with 508, 850 and 1,200 mGy cm in abdomen, abdomen-pelvis and CAP acquisitions respectively. The results of this survey could help in the definition of updated diagnostic reference levels (DRL). (orig.)

  17. A Study on the Operation Strategy for Combined Accident including TLOFW accident

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bo Gyung; Kang, Gook Young [KAIST, Daejeon (Korea, Republic of); Yoon, Ho Joon [Khalifa University, Abu Dhabi (United Arab Emirates)

    2014-10-15

    It is difficult for operators to recognize the necessity of a feed-and-bleed (F-B) operation when the loss of coolant accident and failure of secondary side occur. An F-B operation directly cools down the reactor coolant system (RCS) using the primary cooling system when residual heat removal by the secondary cooling system is not available. The plant is not always necessary the F-B operation when the secondary side is failed. It is not necessary to initiate an F-B operation in the case of a medium or large break because these cases correspond to low RCS pressure sequences when the secondary side is failed. If the break size is too small to sufficiently decrease the RCS pressure, the F-B operation is necessary. Therefore, in the case of a combined accident including a secondary cooling system failure, the provision of clear information will play a critical role in the operators' decision to initiate an F-B operation. This study focuses on the how we establish the operation strategy for combined accident including the failure of secondary side in consideration of plant and operating conditions. Previous studies have usually focused on accidents involving a TLOFW accident. The plant conditions to make the operators confused seriously are usually the combined accident because the ORP only focuses on a single accident and FRP is less familiar with operators. The relationship between CET and PCT under various plant conditions is important to decide the limitation of initiating the F-B operation to prevent core damage.

  18. Study of the weak charged hadronic current in b decays

    Science.gov (United States)

    Acciarri, M.; Adriani, O.; Aguilar-Benitez, M.; Ahlen, S.; Alpat, B.; Alcaraz, J.; Alemanni, G.; Allaby, J.; Aloisio, A.; Alverson, G.; Alviggi, M. G.; Ambrosi, G.; Anderhub, H.; Andreev, V. P.; Angelescu, T.; Anselmo, F.; Antreasyan, D.; Arefiev, A.; Azemoon, T.; Aziz, T.; Bagnaia, P.; Baksay, L.; Ball, R. C.; Banerjee, S.; Banicz, K.; Barillère, R.; Barone, L.; Bartalini, P.; Baschirotto, A.; Basile, M.; Battiston, R.; Bay, A.; Becattini, F.; Becker, U.; Behner, F.; Berdugo, J.; Berges, P.; Bertucci, B.; Betev, B. L.; Bhattacharya, S.; Biasini, M.; Biland, A.; Bilei, G. M.; Blaising, J. J.; Blyth, S. C.; Bobbink, G. J.; Bock, R.; Böhm, A.; Borgia, B.; Boucham, A.; Bourilkov, D.; Bourquin, M.; Boutigny, D.; Branson, J. G.; Brigljevic, V.; Brock, I. C.; Buffini, A.; Buijs, A.; Burger, J. D.; Burger, W. J.; Busenitz, J.; Buytenhuijs, A.; Cai, X. D.; Campanelli, M.; Capell, M.; Romeo, G. Cara; Caria, M.; Carlino, G.; Cartacci, A. M.; Casaus, J.; Castellini, G.; Cavallari, F.; Cavallo, N.; Cecchi, C.; Cerrada, M.; Cesaroni, F.; Chamizo, M.; Chan, A.; Chang, Y. H.; Chaturvedi, U. K.; Chemarin, M.; Chen, A.; Chen, G.; Chen, G. M.; Chen, H. F.; Chen, H. S.; Chen, M.; Chiefari, G.; Chien, C. Y.; Choi, M. T.; Cifarelli, L.; Cindolo, F.; Civinini, C.; Clare, I.; Clare, R.; Cohn, H. O.; Coignet, G.; Colijn, A. P.; Colino, N.; Commichau, V.; Costantini, S.; Cotorobai, F.; de La Cruz, B.; Csilling, A.; Dai, T. S.; D'Alessandro, R.; de Asmundis, R.; de Boeck, H.; Degré, A.; Deiters, K.; Denes, P.; Denotaristefani, F.; Dibitonto, D.; Diemoz, M.; van Dierendonck, D.; di Lodovico, F.; Dionisi, C.; Dittmar, M.; Dominguez, A.; Doria, A.; Dorne, I.; Dova, M. T.; Drago, E.; Duchesneau, D.; Duinker, P.; Duran, I.; Dutta, S.; Easo, S.; Efremenko, Yu.; El Mamouni, H.; Engler, A.; Eppling, F. J.; Erné, F. C.; Ernenwein, J. P.; Extermann, P.; Fabre, M.; Faccini, R.; Falciano, S.; Favara, A.; Fay, J.; Fedin, O.; Felcini, M.; Fenyi, B.; Ferguson, T.; Fernandez, D.; Ferroni, F.; Fesefeldt, H.; Fiandrini, E.; Field, J. H.; Filthaut, F.; Fisher, P. H.; Forconi, G.; Fredj, L.; Freudenreich, K.; Furetta, C.; Galaktionov, Yu.; Ganguli, S. N.; Garcia-Abia, P.; Gau, S. S.; Gentile, S.; Gerald, J.; Gheordanescu, N.; Giagu, S.; Goldfarb, S.; Goldstein, J.; Gong, Z. F.; Gougas, A.; Gratta, G.; Gruenewald, M. W.; Gupta, V. K.; Gurtu, A.; Gutay, L. J.; Hartmann, B.; Hasan, A.; Hatzifotiadou, D.; Hebbeker, T.; Hervé, A.; van Hoek, W. C.; Hofer, H.; Hoorani, H.; Hou, S. R.; Hu, G.; Innocente, V.; Janssen, H.; Jenkes, K.; Jin, B. N.; Jones, L. W.; de Jong, P.; Josa-Mutuberria, I.; Kasser, A.; Khan, R. A.; Kamrad, D.; Kamyshkov, Yu.; Kapustinsky, J. S.; Karyotakis, Y.; Kaur, M.; Kienzle-Focacci, M. N.; Kim, D.; Kim, J. K.; Kim, S. C.; Kim, Y. G.; Kinnison, W. W.; Kirkby, A.; Kirkby, D.; Kirkby, J.; Kiss, D.; Kittel, W.; Klimentov, A.; König, A. C.; Korolko, I.; Koutsenko, V.; Kraemer, R. W.; Krenz, W.; Kuijten, H.; Kunin, A.; de Guevara, P. Ladron; Landi, G.; Lapoint, C.; Lassila-Perini, K.; Laurikainen, P.; Lebeau, M.; Lebedev, A.; Lebrun, P.; Lecomte, P.; Lecoq, P.; Le Coultre, P.; Lee, J. S.; Lee, K. Y.; Leggett, C.; Le Goff, J. M.; Leiste, R.; Leonardi, E.; Levtchenko, P.; Li, C.; Lieb, E.; Lin, W. T.; Linde, F. L.; Lista, L.; Liu, Z. A.; Lohmann, W.; Longo, E.; Lu, W.; Lu, Y. S.; Lübelsmeyer, K.; Luci, C.; Luckey, D.; Luminari, L.; Lustermann, W.; Ma, W. G.; Maity, M.; Majumder, G.; Malgeri, L.; Malinin, A.; Maña, C.; Mangla, S.; Marchesini, P.; Marin, A.; Martin, J. P.; Marzano, F.; Massaro, G. G. G.; McNally, D.; Mele, S.; Merola, L.; Meschini, M.; Metzger, W. J.; von der Mey, M.; Mi, Y.; Mihul, A.; van Mil, A. J. W.; Mirabelli, G.; Mnich, J.; Molnar, P.; Monteleoni, B.; Moore, R.; Morganti, S.; Moulik, T.; Mount, R.; Müller, S.; Muheim, F.; Nagy, E.; Nahn, S.; Napolitano, M.; Nessi-Tedaldi, F.; Newman, H.; Niessen, T.; Nippe, A.; Nisati, A.; Nowak, H.; Opitz, H.; Organtini, G.; Ostonen, R.; Pandoulas, D.; Paoletti, S.; Paolucci, P.; Park, H. K.; Pascale, G.; Passaleva, G.; Patricelli, S.; Paul, T.; Pauluzzi, M.; Paus, C.; Pauss, F.; Peach, D.; Pei, Y. J.; Pensotti, S.; Perret-Gallix, D.; Petrak, S.; Pevsner, A.; Piccolo, D.; Pieri, M.; Pinto, J. C.; Piroué, P. A.; Pistolesi, E.; Plyaskin, V.; Pohl, M.; Pojidaev, V.; Postema, H.; Produit, N.; Prokofiev, D.; Rahal-Callot, G.; Rancoita, P. G.; Rattaggi, M.; Raven, G.; Razis, P.; Read, K.; Ren, D.; Rescigno, M.; Reucroft, S.; van Rhee, T.; Riemann, S.; Riemers, B. C.; Riles, K.; Rind, O.; Ro, S.; Robohm, A.; Rodin, J.; Rodriguez, F. J.; Roe, B. P.; Romero, L.; Rosier-Lees, S.; Rosselet, Ph.; van Rossum, W.; Roth, S.; Rubio, J. A.; Rykaczewski, H.; Salicio, J.; Sanchez, E.; Santocchia, A.; Sarakinos, M. E.; Sarkar, S.; Sassowsky, M.; Sauvage, G.; Schäfer, C.; Schegelsky, V.; Schmidt-Kaerst, S.; Schmitz, D.; Schmitz, P.; Schneegans, M.; Scholz, N.; Schopper, H.; Schotanus, D. J.; Schwenke, J.; Schwering, G.; Sciacca, C.; Sciarrino, D.; Sens, J. C.; Servoli, L.; Shevchenko, S.; Shivarov, N.; Shoutko, V.; Shukla, J.; Shumilov, E.; Shvorob, A.; Siedenburg, T.; Son, D.; Sopczak, A.; Soulimov, V.; Smith, B.; Spillantini, P.; Steuer, M.; Stickland, D. P.; Stone, H.; Stoyanov, B.; Straessner, A.; Strauch, K.; Sudhakar, K.; Sultanov, G.; Sun, L. Z.; Susinno, G. F.; Suter, H.; Swain, J. D.; Tang, X. W.; Tauscher, L.; Taylor, L.; Ting, Samuel C. C.; Ting, S. M.; Tonutti, M.; Tonwar, S. C.; Tóth, J.; Tully, C.; Tuchscherer, H.; Tung, K. L.; Uchida, Y.; Ulbricht, J.; Uwer, U.; Valente, E.; van de Walle, R. T.; Vesztergombi, G.; Vetlitsky, I.; Viertel, G.; Vivargent, M.; Völkert, R.; Vogel, H.; Vogt, H.; Vorobiev, I.; Vorobyov, A. A.; Vorvolakos, A.; Wadhwa, M.; Wallraff, W.; Wang, J. C.; Wang, X. L.; Wang, Z. M.; Weber, A.; Wittgenstein, F.; Wu, S. X.; Wynhoff, S.; Xu, J.; Xu, Z. Z.; Yang, B. Z.; Yang, C. G.; Yao, X. Y.; Ye, J. B.; Yeh, S. C.; You, J. M.; Zalite, An.; Zalite, Yu.; Zemp, P.; Zeng, Y.; Zhang, Z.; Zhang, Z. P.; Zhou, B.; Zhou, Y.; Zhu, G. Y.; Zhu, R. Y.; Zichichi, A.; Ziegler, F.

    1997-02-01

    Charged and neutral particle multiplicities of jets associated with identified semileptonic and hadronic b decays are studied. The observed differences between these jets are used to determine the inclusive properties of the weak charged hadronic current. The average charged particle multiplicity of the weak charged hadronic current in b decays is measured for the first time to be 2.69+/-0.07 (stat.)+/-0.14(syst.). This result is in good agreement with the JETSET hadronization model of the weak charged hadronic current if 40+/-17% of the produced mesons are light-flavored tensor (L=1) mesons. This level of tensor meson production is consistent with the measurement of the π0 multiplicity in the weak charged hadronic current in b decays.

  19. Study of the Weak Charged Hadronic Current in b Decays

    CERN Document Server

    Acciarri, M; Aguilar-Benítez, M; Ahlen, S P; Alpat, B; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alverson, G; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Anselmo, F; Antreasyan, D; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Ball, R C; Banerjee, S; Banicz, K; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Bhattacharya, S; Biasini, M; Biland, A; Bilei, G M; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böck, R K; Böhm, A; Borgia, B; Boucham, A; Bourilkov, D; Bourquin, Maurice; Boutigny, D; Branson, J G; Brigljevic, V; Brock, I C; Buffini, A; Buijs, A; Burger, J D; Burger, W J; Busenitz, J K; Buytenhuijs, A O; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Caria, M; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chan, A; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chen, M; Chiefari, G; Chien, C Y; Choi, M T; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Commichau, V; Costantini, S; Cotorobai, F; de la Cruz, B; Csilling, Akos; Dai, T S; D'Alessandro, R; De Asmundis, R; De Boeck, H; Degré, A; Deiters, K; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dorne, I; Dova, M T; Drago, E; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Fenyi, B; Ferguson, T; Fernández, D; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gau, S S; Gentile, S; Gerald, J; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; Gougas, Andreas; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gutay, L J; Hartmann, B; Hasan, A; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Van Hoek, W C; Hofer, H; Hoorani, H; Hou, S R; Hu, G; Innocente, Vincenzo; Janssen, H; Jenkes, K; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamrad, D; Kamyshkov, Yu A; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kim, S C; Kim, Y G; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Korolko, I; Koutsenko, V F; Krämer, R W; Krenz, W; Kuijten, H; Kunin, A; Ladrón de Guevara, P; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee Jae Sik; Lee, K Y; Leggett, C; Le Goff, J M; Leiste, R; Leonardi, E; Levchenko, P M; Li Chuan; Lieb, E H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Luminari, L; Lustermann, W; Ma Wen Gan; Maity, M; Majumder, G; Malgeri, L; Malinin, A; Maña, C; Mangla, S; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; McNally, D; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mi, Y; Mihul, A; Van Mil, A J W; Mirabelli, G; Mnich, J; Molnár, P; Monteleoni, B; Moore, R; Morganti, S; Moulik, T; Mount, R; Müller, S; Muheim, F; Nagy, E; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nippe, A; Nisati, A; Nowak, H; Opitz, H; Organtini, G; Ostonen, R; Pandoulas, D; Paoletti, S; Paolucci, P; Park, H K; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Peach, D; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Pinto, J C; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Prokofev, D; Prokofiev, D O; Rahal-Callot, G; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riemers, B C; Riles, K; Rind, O; Ro, S; Robohm, A; Rodin, J; Rodríguez-Calonge, F J; Roe, B P; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Rykaczewski, H; Salicio, J; Sánchez, E; Santocchia, A; Sarakinos, M E; Sarkar, S; Sassowsky, M; Sauvage, G; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schmitz, P; Schneegans, M; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schwenke, J; Schwering, G; Sciacca, C; Sciarrino, D; Sens, Johannes C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Sopczak, André; Soulimov, V; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Stone, H; Stoyanov, B; Strässner, A; Strauch, K; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, Samuel C C; Ting, S M; Tonutti, M; Tonwar, S C; Tóth, J; Tully, C; Tuchscherer, H; Tung, K L; Uchida, Y; Ulbricht, J; Uwer, U; Valente, E; Van de Walle, R T; Vesztergombi, G; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Z M; Weber, A; Wittgenstein, F; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zalite, A; Zalite, Yu; Zemp, P; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhou, Y; Zhu, G Y; Zhu, R Y; Zichichi, Antonino; Ziegler, F

    1997-01-01

    Charged and neutral particle multiplicities of jets associated with identified semileptonic and hadronic b decays are studied. The observed differences between these jets are used to determine the inclusive properties of the weak charged hadronic current. The average charged particle multiplicity of the weak charged hadronic current in b decays is measured for the first time to be 2.69$\\pm$0.07(stat.)$\\pm$0.14(syst.). This result is in good agreement with the JETSET hadronization model of the weak charged hadronic current if 40$\\pm$17\\% of the produced mesons are light--flavored tensor (L=1) mesons. This level of tensor meson production is consistent with the measurement of the $\\pi^0$ multiplicity in the weak charged hadronic current in b decays. \\end{abstract}

  20. Critical current studies of a HTS rectangular coil

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Z. [Department of Engineering, University of Cambridge (United Kingdom); Chudy, M., E-mail: Michal.chudy@stuba.sk [Graduate School of Technology Management, University of Pretoria (South Africa); Institute of Power and Applied Electrical Engineering, Slovak University of Technology in Bratislava (Slovakia); Ruiz, H.S. [Department of Engineering, University of Leicester, Leicester LE1 7RH (United Kingdom); Zhang, X.; Coombs, T. [Department of Engineering, University of Cambridge (United Kingdom)

    2017-05-15

    Highlights: • Unique square pancake coil was manufactured. • Measurements in relatively high magnetic field were performed. • Different sections of the coil were characterized. • Parts of the coil which are limiting critical current were identified. - Abstract: Nowadays, superconducting high field magnets are used in numerous applications due to their superior properties. High temperature superconductors (HTS) are usually used for production of circular pancake or racetrack coils. However different geometries of HTS coils might be required for some specific applications. In this study, the HTS coil wound on a rectangular frame was fully characterized in homogeneous DC background field. The study contains measurements of critical current angular dependencies. The critical current of the entire coil and two selected strands under different magnitudes and orientations of external magnetic fields are measured. The critical regions of the coil in different angular regimes are determined. This study brings better understanding of the in- field performance of HTS coils wound on frames with right-angles.

  1. Drug eruptions: An 8-year study including 106 inpatients at a dermatology clinic in Turkey

    Directory of Open Access Journals (Sweden)

    Fatma Akpinar

    2012-01-01

    Full Text Available Background: Few clinical studies are found in the literature about patients hospitalized with a diagnosis of cutaneous drug eruption. Aims: To determine the clinical types of drug eruptions and their causative agents in a hospital-based population. Materials and Methods: This retrospective study was performed in the Dermatology Department of Haseki General Hospital. Through 1751 patients hospitalized in this department between 2002 and 2009, inpatients diagnosed as drug eruption were evaluated according to WHO causality definitions. 106 patients composed of probable and possible cases of cutaneous drug eruptions were included in this study. Results: Seventy one females and 35 males were evolved. Mean age was 44.03±15.14. Duration between drug intake and onset of reaction varied from 5 minutes to 3 months. The most common clinical type was urticaria and/or angioedema in 48.1% of the patients, followed by maculopapular rash in 13.2%, and drug rash with eosinophilia and systemic symptoms in 8.5%. Drugs most frequently associated with cutaneous drug eruptions were antimicrobial agents in 40.5% of the patients, followed by antipyretic/anti-inflammatory analgesics in 31.1%, and antiepileptics in 11.3%. Conclusion: Urticaria and/or angioedema and maculopapular rash comprised majority of the drug eruptions. Rare reactions such as acute generalized exanthematous pustulosis, sweet syndrome, oral ulceration were also found. Antimicrobial agents and antipyretic/anti-inflammatory analgesics were the most commonly implicated drugs. Infrequently reported adverse reactions to myorelaxant agents, newer cephalosporins and fluoroquinolones were also detected. We suppose that studies on drug eruptions should continue, because the pattern of consumption of drugs is changing in every country at different periods and many new drugs are introduced on the market continuously.

  2. Deterministic and Stochastic Study of Wind Farm Harmonic Currents

    DEFF Research Database (Denmark)

    Sainz, Luis; Mesas, Juan Jose; Teodorescu, Remus;

    2010-01-01

    Wind farm harmonic emissions are a well-known power quality problem, but little data based on actual wind farm measurements are available in literature. In this paper, harmonic emissions of an 18 MW wind farm are investigated using extensive measurements, and the deterministic and stochastic...... characterization of wind farm harmonic currents is analyzed. Specific issues addressed in the paper include the harmonic variation with the wind farm operating point and the random characteristics of their magnitude and phase angle....

  3. Nightmares as predictors of suicide: an extension study including war veterans.

    Science.gov (United States)

    Sandman, Nils; Valli, Katja; Kronholm, Erkki; Vartiainen, Erkki; Laatikainen, Tiina; Paunio, Tiina

    2017-03-15

    Nightmares are intensive dreams with negative emotional tone. Frequent nightmares can pose a serious clinical problem and in 2001, Tanskanen et al. found that nightmares increase the risk of suicide. However, the dataset used by these authors included war veterans in whom nightmare frequency - and possibly also suicide risk - is elevated. Therefore, re-examination of the association between nightmares and suicide in these data is warranted. We investigated the relationship between nightmares and suicide both in the general population and war veterans in Finnish National FINRISK Study from the years 1972 to 2012, a dataset overlapping with the one used in the study by Tanskanen et al. Our data comprise 71,068 participants of whom 3139 are war veterans. Participants were followed from their survey participation until the end of 2014 or death. Suicides (N = 398) were identified from the National Causes of Death Register. Frequent nightmares increase the risk of suicide: The result of Tanskanen et al. holds even when war experiences are controlled for. Actually nightmares are not significantly associated with suicides among war veterans. These results support the role of nightmares as an independent risk factor for suicide instead of just being proxy for history of traumatic experiences.

  4. [Baseline clinical characteristics and management of patients included in IBERICAN study].

    Science.gov (United States)

    Barrios, V; Escobar, C; Llisterri, J L; Rodríguez Roca, G; Badimón, J J; Vergara, J; Prieto, M Á; Serrano, A; Cinza, S; Murillo, C

    2015-01-01

    To determine the prevalence and incidence of cardiovascular risk factors and cardiovascular events in Spain, as well as the quality of the follow-up in clinical practice. In this study the baseline data of the first interim analysis of IBERICAN are shown (n=830). IBERICAN is a multicenter, longitudinal and observational population-based study of patients daily attended in primary care setting according to clinical practice in Spain. Subjects between 18 and 85 years daily attended in primary care setting are being included consecutively. Treatment of patients will be performed according only to clinical criteria of investigators. Blood pressure control was defined according to 2013 European guidelines of hypertension; LDL-cholesterol control was defined according to 2012 European guidelines of cardiovascular prevention; diabetes control was defined as HbA1ccardiovascular risk factors with a poor control. Copyright © 2014 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  5. Nightmares as predictors of suicide: an extension study including war veterans

    Science.gov (United States)

    Sandman, Nils; Valli, Katja; Kronholm, Erkki; Vartiainen, Erkki; Laatikainen, Tiina; Paunio, Tiina

    2017-01-01

    Nightmares are intensive dreams with negative emotional tone. Frequent nightmares can pose a serious clinical problem and in 2001, Tanskanen et al. found that nightmares increase the risk of suicide. However, the dataset used by these authors included war veterans in whom nightmare frequency - and possibly also suicide risk - is elevated. Therefore, re-examination of the association between nightmares and suicide in these data is warranted. We investigated the relationship between nightmares and suicide both in the general population and war veterans in Finnish National FINRISK Study from the years 1972 to 2012, a dataset overlapping with the one used in the study by Tanskanen et al. Our data comprise 71,068 participants of whom 3139 are war veterans. Participants were followed from their survey participation until the end of 2014 or death. Suicides (N = 398) were identified from the National Causes of Death Register. Frequent nightmares increase the risk of suicide: The result of Tanskanen et al. holds even when war experiences are controlled for. Actually nightmares are not significantly associated with suicides among war veterans. These results support the role of nightmares as an independent risk factor for suicide instead of just being proxy for history of traumatic experiences. PMID:28294195

  6. Study of Anti-Fatigue Effect in Rats of Ferrous Chelates Including Hairtail Protein Hydrolysates

    Directory of Open Access Journals (Sweden)

    Saibo Huang

    2015-12-01

    Full Text Available The ability of ferrous chelates including hairtail protein hydrolysates to prevent and reduce fatigue was studied in rats. After hydrolysis of hairtail surimi with papain, the hairtail protein hydrolysates (HPH were separated into three groups by range of relative molecular weight using ultrafiltration membrane separation. Hairtail proteins were then chelated with ferrous ions, and the antioxidant activity, the amino acid composition and chelation rate of the three kinds of ferrous chelates including hairtail protein hydrolysates (Fe-HPH were determined. Among the three groups, the Fe-HPH chelate showing the best conditions was selected for the anti-fatigue animal experiment. For it, experimental rats were randomly divided into seven groups. Group A was designated as the negative control group given distilled water. Group B, the positive control group, was given glutathione. Groups C, D and E were designated as the Fe-HPH chelate treatment groups and given low, medium, and high doses, respectively. Group F was designated as HPH hydrolysate treatment group, and Group G was designated as FeCl2 treatment group. The different diets were orally administered to rats for 20 days. After that time, rats were subjected to forced swimming training after 1 h of gavage. Rats given Fe-FPH chelate had higher haemoglobin regeneration efficiency (HRE, longer exhaustive swimming time and higher SOD activity. Additionally, Fe-FPH chelate was found to significantly decrease the malondialdehyde content, visibly enhance the GSH-Px activity in liver and reduce blood lactic acid of rats. Fe-HPH chelate revealed an anti-fatigue effect, similar to or better than the positive control substance and superior to HPH or Fe when provided alone.

  7. Study of Anti-Fatigue Effect in Rats of Ferrous Chelates Including Hairtail Protein Hydrolysates

    Science.gov (United States)

    Huang, Saibo; Lin, Huimin; Deng, Shang-gui

    2015-01-01

    The ability of ferrous chelates including hairtail protein hydrolysates to prevent and reduce fatigue was studied in rats. After hydrolysis of hairtail surimi with papain, the hairtail protein hydrolysates (HPH) were separated into three groups by range of relative molecular weight using ultrafiltration membrane separation. Hairtail proteins were then chelated with ferrous ions, and the antioxidant activity, the amino acid composition and chelation rate of the three kinds of ferrous chelates including hairtail protein hydrolysates (Fe-HPH) were determined. Among the three groups, the Fe-HPH chelate showing the best conditions was selected for the anti-fatigue animal experiment. For it, experimental rats were randomly divided into seven groups. Group A was designated as the negative control group given distilled water. Group B, the positive control group, was given glutathione. Groups C, D and E were designated as the Fe-HPH chelate treatment groups and given low, medium, and high doses, respectively. Group F was designated as HPH hydrolysate treatment group, and Group G was designated as FeCl2 treatment group. The different diets were orally administered to rats for 20 days. After that time, rats were subjected to forced swimming training after 1 h of gavage. Rats given Fe-FPH chelate had higher haemoglobin regeneration efficiency (HRE), longer exhaustive swimming time and higher SOD activity. Additionally, Fe-FPH chelate was found to significantly decrease the malondialdehyde content, visibly enhance the GSH-Px activity in liver and reduce blood lactic acid of rats. Fe-HPH chelate revealed an anti-fatigue effect, similar to or better than the positive control substance and superior to HPH or Fe when provided alone. PMID:26633476

  8. Study of Anti-Fatigue Effect in Rats of Ferrous Chelates Including Hairtail Protein Hydrolysates.

    Science.gov (United States)

    Huang, Saibo; Lin, Huimin; Deng, Shang-Gui

    2015-12-01

    The ability of ferrous chelates including hairtail protein hydrolysates to prevent and reduce fatigue was studied in rats. After hydrolysis of hairtail surimi with papain, the hairtail protein hydrolysates (HPH) were separated into three groups by range of relative molecular weight using ultrafiltration membrane separation. Hairtail proteins were then chelated with ferrous ions, and the antioxidant activity, the amino acid composition and chelation rate of the three kinds of ferrous chelates including hairtail protein hydrolysates (Fe-HPH) were determined. Among the three groups, the Fe-HPH chelate showing the best conditions was selected for the anti-fatigue animal experiment. For it, experimental rats were randomly divided into seven groups. Group A was designated as the negative control group given distilled water. Group B, the positive control group, was given glutathione. Groups C, D and E were designated as the Fe-HPH chelate treatment groups and given low, medium, and high doses, respectively. Group F was designated as HPH hydrolysate treatment group, and Group G was designated as FeCl₂ treatment group. The different diets were orally administered to rats for 20 days. After that time, rats were subjected to forced swimming training after 1 h of gavage. Rats given Fe-FPH chelate had higher haemoglobin regeneration efficiency (HRE), longer exhaustive swimming time and higher SOD activity. Additionally, Fe-FPH chelate was found to significantly decrease the malondialdehyde content, visibly enhance the GSH-Px activity in liver and reduce blood lactic acid of rats. Fe-HPH chelate revealed an anti-fatigue effect, similar to or better than the positive control substance and superior to HPH or Fe when provided alone.

  9. Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption

    Directory of Open Access Journals (Sweden)

    M. Cristina Benéitez

    2017-01-01

    Full Text Available Background. Detoxification programmes seek to implement the most secure and compassionate ways of withdrawing from opiates so that the inevitable withdrawal symptoms and other complications are minimized. Once detoxification has been achieved, the next stage is to enable the patient to overcome his or her drug addiction by ensuring consumption is permanently and completely abandoned, only after which can the subject be regarded as fully recovered. Methods. A systematic search on the common databases of relevant papers published until 2016 inclusive. Results and Conclusion. Our study of the available oral treatments for opioid dependence has revealed that no current treatment can actually claim to be fully effective. These treatments require daily oral administration and, consequently, regular visits to dispensaries, which in most cases results in a lack of patient compliance, which causes fluctuations in drug plasma levels. We then reviewed alternative treatments in the available scientific literature on polymeric sustained release formulations. Research has been done not only on release systems for detoxification but also on release systems for giving up the habit of taking opioids. These efforts have obtained the recent authorization of polymeric systems for use in patients that could help them to reduce their craving for drugs.

  10. Should abdominal sequences be included in prostate cancer MR staging studies?

    Energy Technology Data Exchange (ETDEWEB)

    McEvoy, S.H., E-mail: sineadhmcevoy@gmail.com [Department of Radiology, St. Vincent' s University Hospital, Dublin 4 (Ireland); Lavelle, L.P.; Purcell, Y.M. [Department of Radiology, St. Vincent' s University Hospital, Dublin 4 (Ireland); Quinlan, D.M. [Department of Urology, St. Vincent' s University Hospital, Dublin 4 (Ireland); Skehan, S.J.; Collins, C.D.; McMahon, C.J. [Department of Radiology, St. Vincent' s University Hospital, Dublin 4 (Ireland)

    2015-06-15

    Highlights: • ESUR guideline that abdominal MR sequences are reserved for high-risk prostate cancer is tested. • Routine abdominal sequences are of low yield in prostate cancer MR staging. • Routine abdominal staging sequences frequently result in incidental findings. • Abdominal staging sequences should be reserved for high-risk prostate cancer cases. - Abstract: Objectives: Prostate cancer staging MR examinations commonly include abdominal sequences to assess for non-regional (common iliac or para-aortic) nodal metastasis. In our experience the diagnostic yield of this is limited, but incidental findings are frequent, often necessitating further investigations. The aim of this study is to assess the diagnostic utility of abdominal sequences in routine prostate cancer MR staging studies. Methods: Findings on abdominal sequences of consecutive MRI prostate studies performed for staging newly diagnosed prostate cancer between September 2011 and September 2013 were reviewed with respect to adenopathy and additional incidental findings. Results were correlated with Gleason grade and serum prostate-specific antigen (PSA) level in each case. Results: 355 MRI prostate examinations were reviewed. 4 (1.1%) showed enlarged non-regional lymph nodes. Incidental findings were found in 82(23.1%) cases, neccessitating further investigation in 45 (12.7%) cases. Enlarged non-regional nodes were associated with higher PSA level and Gleason grade (p = 0.007, p = 0.005 respectively). With a combined threshold of PSA > 20 ng/mL and/or Gleason grade ≥8 the sensitivity, specificity, PPV and NPV were 100, 60, 3 and 100% respectively for predicting the presence of non-regional adenopathy. Conclusions: Routine abdominal sequences are of very low yield in routine prostate cancer MR staging, frequently resulting in incidental findings requiring further work-up and should be reserved for high-risk cases. Our experience supports the use of an abdominal staging sequence in high

  11. [Bipolar disorder and quality of life: A cross-sectional study including 104 Tunisian patients].

    Science.gov (United States)

    Marrag, I; Hajji, K; Hadj Ammar, M; Zarrouk, L; Kachouri, R; Nasr, M

    2015-09-01

    Bipolar disorder affects many psychosocial and functional aspects, leading to a real social handicap and an alteration in quality of life. To evaluate bipolar patients' quality of life and to identify the risk factors responsible for a deterioration. Our cross-sectional study lasted for four months and included 104 bipolar patients treated at the psychiatry consultation of the university hospital in Mahdia. The data were collected through a questionnaire composed of 52 items exploring the general characteristics of subjects, the clinical and evolutional characteristics of bipolar disorder and providing information on the treatment. Quality of life was measured using the SF-36 (Short form) generic scale. A global average score was calculated and it was considered that quality of life was altered if the score was less than 66.7, according to the threshold value of Léan. Moreover, an average score was calculated for each dimension, thus permitting us to identify those most affected. We standardized initial average scores. The assessment of quality of life revealed a global average of 52.2 and an alteration in 78.8% of patients. The study of the dimensional average scores revealed that all dimensions were affected. The standardization also revealed deterioration in all dimensions, the mental component being particularly more affected than the physical component with respectively estimated scores of 31.7 and 40.5. The analytic approach concerned the relationship between qualitative and quantitative variables and the occurrence of an alteration in quality of life. For this effect, a bivariate study displayed a statistically significant correlation between the eight dimensions of the SF-36 and 8 variables. In order to take into account the relationships that link each variable to the others, and to avoid the bias of the bivariate study, a logistic regression analysis was performed. Only 4 variables with discriminating weight emerged from this analysis. According to the

  12. Truly included? A literature study focusing on the social dimension of inclusion in education

    NARCIS (Netherlands)

    Bossaert, Goele; Colpin, Hilde; Pijl, Sip Jan; Petry, Katja

    2013-01-01

    Social participation of students with special educational needs (SEN) is a key issue in the inclusion debate. However, the meaning of concepts like social integration, social inclusion and social participation used in current literature is often unclear. Recently, these concepts were clarified based

  13. Truly included? A literature study focusing on the social dimension of inclusion in education

    NARCIS (Netherlands)

    Bossaert, Goele; Colpin, Hilde; Pijl, Sip Jan; Petry, Katja

    2013-01-01

    Social participation of students with special educational needs (SEN) is a key issue in the inclusion debate. However, the meaning of concepts like social integration, social inclusion and social participation used in current literature is often unclear. Recently, these concepts were clarified based

  14. Truly Included? A Literature Study Focusing on the Social Dimension of Inclusion in Education

    Science.gov (United States)

    Bossaert, Goele; Colpin, Hilde; Pijl, Sip Jan; Petry, Katja

    2013-01-01

    Social participation of students with special educational needs (SEN) is a key issue in the inclusion debate. However, the meaning of concepts like social integration, social inclusion and social participation used in current literature is often unclear. Recently, these concepts were clarified based on preschool and primary school literature. The…

  15. Truly Included? A Literature Study Focusing on the Social Dimension of Inclusion in Education

    Science.gov (United States)

    Bossaert, Goele; Colpin, Hilde; Pijl, Sip Jan; Petry, Katja

    2013-01-01

    Social participation of students with special educational needs (SEN) is a key issue in the inclusion debate. However, the meaning of concepts like social integration, social inclusion and social participation used in current literature is often unclear. Recently, these concepts were clarified based on preschool and primary school literature. The…

  16. How to include the variability of TMS responses in simulations: a speech mapping case study

    Science.gov (United States)

    De Geeter, N.; Lioumis, P.; Laakso, A.; Crevecoeur, G.; Dupré, L.

    2016-11-01

    When delivered over a specific cortical site, TMS can temporarily disrupt the ongoing process in that area. This allows mapping of speech-related areas for preoperative evaluation purposes. We numerically explore the observed variability of TMS responses during a speech mapping experiment performed with a neuronavigation system. We selected four cases with very small perturbations in coil position and orientation. In one case (E) a naming error occurred, while in the other cases (NEA, B, C) the subject appointed the images as smoothly as without TMS. A realistic anisotropic head model was constructed of the subject from T1-weighted and diffusion-weighted MRI. The induced electric field distributions were computed, associated to the coil parameters retrieved from the neuronavigation system. Finally, the membrane potentials along relevant white matter fibre tracts, extracted from DTI-based tractography, were computed using a compartmental cable equation. While only minor differences could be noticed between the induced electric field distributions of the four cases, computing the corresponding membrane potentials revealed different subsets of tracts were activated. A single tract was activated for all coil positions. Another tract was only triggered for case E. NEA induced action potentials in 13 tracts, while NEB stimulated 11 tracts and NEC one. The calculated results are certainly sensitive to the coil specifications, demonstrating the observed variability in this study. However, even though a tract connecting Broca’s with Wernicke’s area is only triggered for the error case, further research is needed on other study cases and on refining the neural model with synapses and network connections. Case- and subject-specific modelling that includes both electromagnetic fields and neuronal activity enables demonstration of the variability in TMS experiments and can capture the interaction with complex neural networks.

  17. Synthesis, optical and electrochemical study of bipolar heterocyclic systems, including 1,2,4-oxadiazole moiety

    Science.gov (United States)

    Selivanova, D. G.; Mayorova, O. A.; Gorbunov, A. A.; Vasyanin, A. N.; Dmitriev, M. V.; Shklyaeva, E. V.; Abashev, G. G.

    2016-12-01

    Two new 3,5-dihetarylsubstituted 1,2,4- oxadiazoles 8 a,b, including N-alkyl substituted carbazole and thiophene moieties, were synthesized as potential components of materials for organic electronics devices. Optical and electrochemical properties of all new compounds were investigated. On the basis of the experimental UV absorption data, the values of bandgap energies equal to 3.44 eV (8a) and 3.05 eV (8b) were determined. The values of their ionization potentials, HOMO levels (-5.62 eV for 8a, -5.46 eV - for 8b), as well as their electron affinity levels, LUMO levels (-2.2 eV for 8a, -2.4 eV - for 8b), were calculated from the results of electrochemical studies. The energy of the triplet excited states of 8 a,b was defined with the help of time-dependent density functional theory (TD-DFT), comprising 2.68 eV (8a) and 2.32 eV (8b), where the greatest value of this parameter was for the compound with a shorter conjugation chain.

  18. A Study of the Radiotherapy Techniques for the Breast Including Internal Mammary Lymph Nodes

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kyoung Keun; Shim, Su Jung; You, Sei Hwan; Kim, Yong Bae; Keum, Ki Chang; Kim, Jong Dae; Suh, Chang Ok [Yonsei Cancer Center, Seoul (Korea, Republic of)

    2009-03-15

    This study was designed to determine the optimum radiotherapy technique for internal mammary node (IMN) irradiation after breast-conserving surgery. We selected ten cases of early stage partial mastectomy for plan comparison. Five of the patients were treated to the right-side breast and the rest of the patients were treated to the left-side breast. For each case, four different treatment plans were made to irradiate the entire breast, IMNs and supraclavicular lymph nodes (SCLs). The four planning techniques include a standard tangential field (STF), wide tangential field (WTF), partially wide tangential field (PWT) and a photon-electron mixed field (PEM). We prescribed a dose of 50.4 Gy to the SCL field at a 3 cm depth and isocenter of the breast field. The dose distribution showed clear characteristics depending on the technique used. All of the techniques covered the breast tissue well. IMN coverage was also good, except for the STF, which was not intended to cover IMNs. For the cases of the left-side breasts, the volume of the heart that received more than 30 Gy was larger (in order) for the WTF, PWT, PEM and STF. For radiation pneumonitis normal tissue complication probability (NTCP), the PWT showed the best results followed by the STF. Despite the variety of patient body shapes, the PWT technique showed the best results for coverage of IMNs and for reducing the lung and heart dose.

  19. Current research projects on traffic conflicts technique studies.

    NARCIS (Netherlands)

    Hondel, M. van den & and Kraay, J.H.

    1979-01-01

    A review of current research concerning the development, evaluation and use of the traffic conflicts technique is presented. The 32 studies, selected from the IRRD data base, are listed alphabetically by names of countries and under countries by names of research organizations. The IRRD descriptions

  20. Subminiature eddy current transducers for studying boride coatings

    Science.gov (United States)

    Dmitriev, S. F.; Ishkov, A. V.; Malikov, V. N.; Sagalakov, A. M.

    2016-07-01

    Strengthening of parts and units of machines, increased reliability and longer service life is an important task of modern mechanical engineering. The main objects of study in the work were selected steel 65G and 50HGA, wear-resistant boride coatings ternary system Fe-B-Fe n B which were investigated by scanning electron microscopy and eddy-current nondestructive methods.

  1. A study of eddy current measurement (1986-1987)

    Energy Technology Data Exchange (ETDEWEB)

    Ramachandran, R.S.; Armstrong, K.P.

    1989-06-22

    A study was conducted in 1986 to evaluate a modified eddy current system for measuring copper thickness on Kapton. Results showed a measurement error of 0.42 {mu}in. for a thickness range of 165 to 170 {mu}in. and a measurement variability of 3.2 {mu}in.

  2. Cartography and Population Geography as Current Events: A Case Study

    Science.gov (United States)

    Comenetz, Joshua

    2003-01-01

    The Sanders housing lawsuit in Pennsylvania provides a case study of how to incorporate current events into the teaching of cartography or population geography at the high school or college level. Settlement of the Sanders case resulted in the release of information about the segregation of public housing by race in the Pittsburgh area. The issues…

  3. Differential Thermostimulated Discharge Current Method for Studying Electrets

    Science.gov (United States)

    Mekishev, G. A.; Yovcheva, T. A.; Viraneva, A. P.; Gencheva, E. A.

    2010-01-01

    The thermostimulated discharge current method (TSDC) is widely used for the study of charge storage mechanisms in electrets. A new discharged technique, called differential, which consists in discharging a charged sample through an otherwise identical but uncharged one, has been proposed by J.-P. Reboul and A. Toureille. In the present paper a new version of the differential thermostimulated discharge current method is advanced. In contrast to the differential technique described earlier, the measuring cell allows to realize typical differential technique. In this case the measuring system records the difference of the thermostimulated currents of two samples which have been preliminary charged (or thermally treated) under the same or different conditions. Samples of 0.85 mm thick polymethylmethacrylate are used to demonstrate an operation of the developed differential TSDC method.

  4. Study on Fault Current of DFIG during Slight Fault Condition

    Directory of Open Access Journals (Sweden)

    Xiangping Kong

    2013-04-01

    Full Text Available In order to ensure the safety of DFIG when severe fault happens, crowbar protection is adopted. But during slight fault condition, the crowbar protection will not trip, and the DFIG is still excited by AC-DC-AC converter. In this condition, operation characteristics of the converter have large influence on the fault current characteristics of DFIG. By theoretical analysis and digital simulation, the fault current characteristics of DFIG during slight voltage dips are studied. And the influence of controller parameters of converter on the fault current characteristics is analyzed emphatically. It builds a basis for the construction of relay protection which is suitable for the power gird with accession of DFIG.

  5. Elaboration of a guide including relevant project and logistic information: a case study

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Tchaikowisky M. [Faculdade de Tecnologia e Ciencias (FTC), Itabuna, BA (Brazil); Bresci, Claudio T.; Franca, Carlos M.M. [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    For every mobilization of a new enterprise it is necessary to quickly obtain the greatest amount of relative information in regards to location and availability of infra-structure, logistics, and work site amenities. Among this information are reports elaborated for management of the enterprise, (organizational chart, work schedule, objectives, contacts, etc.) as well as geographic anomalies, social-economic and culture of the area to be developed such as territorial extension, land aspects, local population, roads and amenities (fuel stations ,restaurants and hotels), infra-structure of the cities (health, education, entertainment, housing, transport, etc.) and logistically the distance between cities the estimated travel time, ROW access maps and notable points, among other relevant information. With the idea of making this information available for everyone involved in the enterprise, it was elaborated for GASCAC Spread 2A a rapid guide containing all the information mentioned above and made it available for all the vehicles used to transport employees and visitors to the spread. With this, everyone quickly received the majority of information necessary in one place, in a practical, quick, and precise manner, since the information is always used and controlled by the same person. This study includes the model used in the gas pipeline GASCAC Spread 2A project and the methodology used to draft and update the information. Besides the above, a file in the GIS format was prepared containing all necessary planning, execution and tracking information for enterprise activities, from social communication to the execution of the works previously mentioned. Part of the GIS file information was uploaded to Google Earth so as to disclose the information to a greater group of people, bearing in mind that this program is free of charge and easy to use. (author)

  6. Configuration interaction studies on the spectroscopic properties of PbO including spin orbit coupling

    Institute of Scientific and Technical Information of China (English)

    罗旺; 李瑞; 盖志强; 艾瑞波; 张宏民; 张晓美; 闫冰

    2016-01-01

    Lead oxide (PbO), which plays the key roles in a range of research fields, has received a great deal of attention. Owing to the large density of electronic states and heavy atom Pb including in PbO, the excited states of the molecule have not been well studied. In this work, high level multireference configuration interaction calculations on the low-lying states of PbO have been carried out by utilizing the relativistic effective core potential. The effects of the core-valence correlation correction, the Davidson modification, and the spin–orbital coupling on the electronic structure of the PbO molecule are estimated. The potential energy curves of 18Λ-S states correlated to the lowest dissociation limit (Pb (3Pg)+O(3Pg)) are reported. The calculated spectroscopic parameters of the electronic states below 30000 cm−1, for instance, X1Σ+, 13Σ+, and 13Σ−, and their spin–orbit coupling interaction, are compared with the experimental results, and good agreements are derived. The dipole moments of the 18Λ-S states are computed with the configuration interaction method, and the calculated dipole moments of X1Σ+and 13Σ+are consistent with the previous experimental results. The transition dipole moments from 11Π, 21Π, and 21Σ+to X1Σ+and other singlet excited states are estimated. The radiative lifetime of several low-lying vibrational levels of 11Π, 21Π, and 21Σ+states are evaluated.

  7. Configuration interaction studies on the spectroscopic properties of PbO including spin-orbit coupling

    Science.gov (United States)

    Wang, Luo; Rui, Li; Zhiqiang, Gai; RuiBo, Ai; Hongmin, Zhang; Xiaomei, Zhang; Bing, Yan

    2016-07-01

    Lead oxide (PbO), which plays the key roles in a range of research fields, has received a great deal of attention. Owing to the large density of electronic states and heavy atom Pb including in PbO, the excited states of the molecule have not been well studied. In this work, high level multireference configuration interaction calculations on the low-lying states of PbO have been carried out by utilizing the relativistic effective core potential. The effects of the core-valence correlation correction, the Davidson modification, and the spin-orbital coupling on the electronic structure of the PbO molecule are estimated. The potential energy curves of 18 Λ-S states correlated to the lowest dissociation limit (Pb (3Pg) + O(3Pg)) are reported. The calculated spectroscopic parameters of the electronic states below 30000 cm-1, for instance, X1Σ+, 13Σ+, and 13Σ-, and their spin-orbit coupling interaction, are compared with the experimental results, and good agreements are derived. The dipole moments of the 18 Λ-S states are computed with the configuration interaction method, and the calculated dipole moments of X1Σ+ and 13Σ+ are consistent with the previous experimental results. The transition dipole moments from 11Π, 21Π, and 21Σ+ to X1Σ+ and other singlet excited states are estimated. The radiative lifetime of several low-lying vibrational levels of 11Π, 21Π, and 21Σ+ states are evaluated. Project supported by the National Natural Science Foundation of China (Grant Nos. 11404180 and 11574114), the Natural Science Foundation of Heilongjiang Province, China (Grant No. A2015010), the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province, China (Grant No. UNPYSCT-2015095), and the Natural Science Foundation of Jilin Province, China (Grant No. 20150101003JC).

  8. Nonrandomized studies are not always found even when selection criteria for health systems intervention reviews include them: a methodological study.

    Science.gov (United States)

    Glenton, Claire; Lewin, Simon; Mayhew, Alain; Scheel, Inger; Odgaard-Jensen, Jan

    2013-04-01

    Systematic reviews within the Cochrane Effective Practice and Organisation of Care Group (EPOC) can include both randomized and nonrandomized study designs. We explored how many EPOC reviews consider and identify nonrandomized studies, and whether the proportion of nonrandomized studies identified is linked to the review topic. We recorded the study designs considered in 65 EPOC reviews. For reviews that considered nonrandomized studies, we calculated the proportion of identified studies that were nonrandomized and explored whether there were differences in the proportion of nonrandomized studies according to the review topic. Fifty-one (78.5%) reviews considered nonrandomized studies. Forty-six of these reviews found nonrandomized studies, but the proportion varied a great deal (median, 33%; interquartile range, 25--50%). Reviews of health care delivery interventions had lower proportions of nonrandomized studies than those of financial and governance interventions. Most EPOC reviews consider nonrandomized studies, but the degree to which they find them varies. As nonrandomized studies are believed to be at higher risk of bias and their inclusion entails a considerable effort, review authors should consider whether the benefits justify the inclusion of these designs. Research should explore whether it is more useful to consider nonrandomized studies in reviews of some intervention types than others. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Experimental Study on Current Decay Characteristics of Persistent Current HTS Magnet by Alternating Magnetic Field

    Science.gov (United States)

    Park, Young Gun; Lee, Chang Young; Hwang, Young Jin; Lee, Woo Seung; Lee, Jiho; Jo, Hyun Chul; Chung, Yoon Do; Ko, Tae Kuk

    This paper deals with a current decay characteristics of a high temperature superconducting (HTS) magnet operated in persistent current mode (PCM). In superconducting synchronous machine applications such as linear synchronous motor (LSM), the superconducting coil is designed to operate in the PCM to obtain steady magnetic field with DC transport current. This superconducting magnet operates on a direct current, but it can be exposed to alternating magnetic field due to the armature winding. When the magnet is subjected to an external time-varying magnetic field, it is possible to result in a decay of the current in PCM system due to AC loss. In this research, a PCM system with armature coil which generates time-varying magnetic field was fabricated to verify current decay characteristics by external alternating magnetic field. The current decay rate was measured by using a hall sensor as functions of amplitude and frequency of armature coil.

  10. Air Quality Study Using Satellites - Current Capability and Future Plans

    Science.gov (United States)

    Bhartia, Pawan K.; Joiner, Joanna; Gleason, James; Liu, Xiong; Torres, Omar; Krotkov, Nickolay; Ziemke, Jerry; Chandra, Sushil

    2008-01-01

    Satellite instruments have had great success in monitoring the stratospheric ozone and in understanding the processes that control its daily to decadal scale variations. This field is now reaching its zenith with a number of satellite instruments from the US, Europe and Canada capping several decades of active research in this field. The primary public policy imperative of this research was to make reliable prediction of increases in biologically active surface UV radiation due to human activity. By contrast retrieval from satellite data of atmospheric constituents and photo-chemically active radiation that affect air quality is a new and growing field that is presenting us with unique challenges in measurement and data interpretation. A key distinction compared to stratospheric sensors is the greatly enhanced role of clouds, aerosols, and surfaces (CAS) in determining the quality and quantity of useful data that is available for air quality research. In our presentation we will use data from several sensors that are currently flying on the A-train satellite constellation, including OMI, MODIS, CLOUDSAT, and CALIPSO, to highlight that CAS can have both positive and negative effects on the information content of satellite measurements. This is in sharp contrast to other fields of remote sensing where CAS are usually considered an interference except in those cases when they are the primary subject of study. Our analysis has revealed that in the reflected wavelengths one often sees much further down into the atmosphere, through most cirrus, than one does in the emitted wavelengths. The lower level clouds provide a nice background against which one can track long-range transport of trace gases and aerosols. In addition, differences in trace gas columns estimated over cloudy and adjacent clear pixels can be used to measure boundary layer trace gases. However, in order to take full advantage of these features it will be necessary to greatly advance our understanding of

  11. Pancreatic exocrine studies in intact animals: historic and current methods.

    Science.gov (United States)

    Niebergall-Roth, E; Teyssen, S; Singer, M V

    1997-12-01

    This report presents a review of the historic and current methods for performing pancreatic exocrine studies in intact animals. Special emphasis is given to the various surgical procedures--pancreatic fistulas, duodenal pouches, and duodenal fistulas--and practice of collecting pancreatic secretion in dogs. Procedures in other animal species--rat, cat, pig, rabbit, cattle, sheep, and horse--also are specified. The advantages and disadvantages, as well as the indications and limitations of the distinct methods, are discussed.

  12. Study of the Charge Density Control Method Including the Space Charge Effect in the Proton Synchrotron

    Science.gov (United States)

    Kato, Shinichi; Harada, Hiroyuki; Hotchi, Hideaki; Okabe, Kota; Yamamoto, Kazami; Kinsho, Michikazu

    For high intensity proton accelerators, one of the beam loss sources is the incoherent tune spread caused by the space charge force. In the 3 GeV rapid cycling synchrotron of the Japan Proton Accelerator Research Complex, beams are injected sequentially and shifted slightly from the central orbit in order to increase the beam size intentionally and suppress the charge density and incoherent tune spread. This injection method has been adopted and suppressed the beam loss. However, simulations clarified that beams did not spread as much as expected because of the space charge effect in the high current case. As simulation results of the optimized beam shift pattern when the space charge effect is considered, it was obtained that the incoherent tune spread could be suppressed to an extent that has not been achieved previously.

  13. A study of a hamiltonian model for martensitic phase transformations including microkinetic energy

    CERN Document Server

    Theil, F

    1998-01-01

    How can a system in a macroscopically stable state explore energetically more favorable states, which are far away from the current equilibrium state? Based on continuum mechanical considerations we derive a Boussinesq-type equation which models the dynamics of martensitic phase transformations. The solutions of the system, which we refer to as microkinetically regularized wave equation exhibit strong oscillations after short times, thermalization can be confirmed. That means that macroscopic fluctuations of the solutions decay at the benefit of microscopic fluctuations. First analytical and numerical results on the propagation of phase boundaries and thermalization effects are presented. Despite the fact that model is conservative, it exhibits the hysteretic behavior. Such a behavior is usually interpreted in macroscopic models in terms of dissipative threshold which the driving force has to overcome to ensure that the phase transformation proceeds. The threshold value depends on the amount of the transforme...

  14. MIXED FINITE ELEMENT METHODS FOR THE SHALLOW WATER EQUATIONS INCLUDING CURRENT AND SILT SEDIMENTATION ( Ⅱ )-THE DISCRETE-TIME CASE ALONG CHARACTERISTICS

    Institute of Scientific and Technical Information of China (English)

    罗振东; 朱江; 曾庆存; 谢正辉

    2004-01-01

    The mixed finite element (MFE) methods for a shallow water equation system consisting of water dynamics equations, silt transport equation, and the equation of bottom topography change were derived. A fully discrete MFE scheme for the discrete-time along characteristics is presented and error estimates are established. The existence and convergence of MFE solution of the discrete current velocity, elevation of the bottom topography, thickness of fluid column, and mass rate of sediment is demonstrated.

  15. Risk of Cancer in relation to Natural Radiation, including Radon: Evidence from Epidemiological Studies

    Science.gov (United States)

    Baysson, Hélène; Tirmarche, Margot; Laurier, Dominique

    2008-08-01

    A review of recently published epidemiological studies on populations exposed to natural background ionizing radiation is proposed. The advantages and disadvantages of different types of epidemiological studies as well as the uncertainty linked to multiple exposures are discussed. As radon is the greatest source of natural radiation, particular attention is given to quantification of risk obtained through cohort studies of uranium miners and after joint analysis of case-control studies on lung cancer and residential radon.

  16. Slowly progressive fluent aphasia; Clinical features and an imaging study including MRI, SPECT and PET

    Energy Technology Data Exchange (ETDEWEB)

    Sakurai, Yasuhisa; Momose, Toshimitsu; Watanabe, Toshiaki; Ishikawa, Takashi; Iwata, Makoto (Tokyo Univ. (Japan). Faculty of Medicine); Bando, Mitsuaki

    1991-05-01

    Three patients with slowly progressive fluent aphasia are reported. One of the patients presented with memory disturbance. They were characterized clinically by having selective deficits in vocabulary, which resulted in impairment of confrontation naming, and auditory comprehension. MRI showed an atrophy not only in the left temporal lobe (including the superior, middle and inferior temporal gyri), hippocampus, parahippocampual gyrus, and fusiform gyrus, but also in the left parietal lobe. I-123 IMP SPECT and F-18 FDG PET were used to determine regional cerebral blood flow and regional cerebral metabolic rate, respectively. In addition to the decreased tracer uptake in the left temporal and/or parietal lobe, a decreased uptake was seen in the bilateral basal ganglia, the inner side of the temporal lobe (including the bilateral hippocampus), the right anterior temporal lobe, and the left thalamus. These findings may deny the previous thought that lesions are localized in slowly progressive fluent aphasia. Furthermore, noticeable difficulty in naming, i.e., patients unable to recognize the right answer, are considered attributable to widespread lesions from the whole left temporal lobe, including the hippocampus, to the right temporal lobe. (N.K.).

  17. Current Status of Integral Medical Study on Endometriosis

    Institute of Scientific and Technical Information of China (English)

    YU Chao-qin (俞超芹); YU Jin (俞瑾)

    2003-01-01

    @@ Endometriosis (EM), an estrogen dependent disease that comes from the planting of endometrial gland and stroma outside the uterine cavity, is characterized by invasiveness, wide planting and liability to relapse. It has been proved by recent studies that the pathogenesis of EM has its genetic background and is closely related with neuro-, endocrino- and immuno-factors. There has been great progress in the treatment of EM, but the clinical effect is not yet satisfactory. Traditional Chinese medicine (TCM) has definitely played its role in EM treatment. In this article, the current status of integral medical study on EM is reviewed.

  18. A general review of concepts for reducing skin friction, including recommendations for future studies

    Science.gov (United States)

    Fischer, M. C.; Ash, R. L.

    1974-01-01

    Four main concepts which have significantly reduced skin friction in experimental studies are discussed; suction, gaseous injection, particle additives, and compliant wall. It is considered possible that each of these concepts could be developed and applied in viable skin friction reduction systems for aircraft application. Problem areas with each concept are discussed, and recommendations for future studies are made.

  19. Community Biodiversity Management and Empowerment : Documentation of the Sites included in a Global Study

    NARCIS (Netherlands)

    Thijssen, M.H.; Boef, de W.S.; Borman, G.D.

    2012-01-01

    This document contains comprehensive descriptions of all the sites in which the Global CBM Study was conducted. For brevity, future publications sharing results, conclusions and experiences of the Global CBM Study will omit such detailed descriptions and instead will provide reference to this public

  20. Synthesis, optical and electrochemical study of bipolar heterocyclic systems, including 1,2,4-oxadiazole moiety

    OpenAIRE

    Selivanova D. G.; Mayorova O. A.; Gorbunov A.A.; Vasyanin A. N.; Dmitriev M. V.; Shklyaeva E. V.; Abashev G.G.

    2016-01-01

    Two new 3,5-dihetarylsubstituted 1,2,4- oxadiazoles 8 a,b, including N-alkyl substituted carbazole and thiophene moieties, were synthesized as potential components of materials for organic electronics devices. Optical and electrochemical properties of all new compounds were investigated. On the basis of the experimental UV absorption data, the values of bandgap energies equal to 3.44 eV (8a) and 3.05 eV (8b) were determined. The values of their ionization potentials, H...

  1. Kundalini yoga as mutual recovery: a feasibility study including children in care and their carers

    OpenAIRE

    Perez, Elvira; Ball, Mark; Brown, Poppy; Crepaz-Keay, David; Haslam-Jones, Emily; Crawford, Paul

    2016-01-01

    This is a mixed-methods feasibility study to test whether incorporating a 20-week Kundalini yoga program into a children’s home community improves wellbeing outcomes. Feasibility was assessed through recruitment and retention rates as well as participants’ self-report perceptions on social inclusion, mental health, wellbeing and semi-structured interviews on the benefits of the study. Mutual recovery entailed that children in care (CiC), youth practitioners, and management participated togeth...

  2. Large A.C. machines theory and investigation methods of currents and losses in stator and rotor meshes including operation with nonlinear loads

    CERN Document Server

    Boguslawsky, Iliya; Hayakawa, Masashi

    2017-01-01

    In this monograph the authors solve the modern scientific problems connected with A.C. motors and generators, based first on the detailed consideration of their physical phenomena. The authors describe the theory and investigative methods they developed and applied in practice, which are considered to be of essential interest for specialists in the field of the electrical engineering industry in European countries, the USA, Argentina, and Brazil, as well as in such countries as India, China, and Iran. This book will be of interest to engineers specialized in the field of the manufacture, operation, and repair of A.C. machines (motors and generators) as well as electric drives; to professors, lecturers, and post-graduate students of technical universities, who are specializing in the field of electric machine engineering and electric drives; and to students who are engaged in the field of high current techniques, electric drives, and electric machine engineering.

  3. Including Visually Impaired Students in Physical Education Lessons: A Case Study of Teacher and Pupil Experiences

    Science.gov (United States)

    Herold, Frank; Dandolo, Jack

    2009-01-01

    Following recent education policy and curriculum changes in England, the notion of inclusion of children with special educational needs in physical education has increasingly become a topic of research interest and concern. It was the aim of this study to explore personal experiences and perspectives of inclusion in physical education. To this end…

  4. Two phase formation of massive elliptical galaxies : study through cross-correlation including spatial effect

    CERN Document Server

    Modak, Soumita; Chattopadhyay, Asis Kumar

    2016-01-01

    Formation mechanism of present day population of elliptical galaxies have been revisited in the context of hierarchical cosmological models accompanied by accretion and minor mergers through cross correlation function including spatial effect. The present work investigates the formation and evolution of several components of nearby massive early type galaxies (ETGs) through cross-correlation in the spatial coordinates, right ascension and declination (RA, DEC) and mass-size parameter space with high redshift $(0.5\\leq z\\leq2.7)$ ETGs. It is found that innermost components of nearby ETGs are highly correlated with ETGs in the redshift range $(2\\leq z\\leq2.7)$ known as 'red nuggets'. The intermediate and outermost parts have moderate correlations with ETGs in the redshift range $(0.5\\leq z\\leq0.75)$. The quantitative measures are highly consistent with the two phase formation scenario of massive nearby early type galaxies as suggested by various authors and resolves the conflict raised in a previous work sugges...

  5. Paying research participants: a study of current practices in Australia.

    Science.gov (United States)

    Fry, C L; Ritter, A; Baldwin, S; Bowen, K J; Gardiner, P; Holt, T; Jenkinson, R; Johnston, J

    2005-09-01

    To examine current research payment practices and to inform development of clearer guidelines for researchers and ethics committees. Exploratory email based questionnaire study of current research participant reimbursement practices. A diverse sample of organisations and individuals were targeted. Australia. Contacts in 84 key research organisations and select electronic listservers across Australia. A total of 100 completed questionnaires were received with representations from a variety of research areas (for example, market, alcohol and drug, medical, pharmaceutical and social research). Open-ended and fixed alternative questions about type of research agency; type of research; type of population under study; whether payment is standard; amounts and mechanisms of payment; factors taken into account when deciding on payment practices; and whether payment policies exist. Reimbursement practice is highly variable. Where it occurs (most commonly for drug dependent rather than health professional or general population samples) it is largely monetary and is for time and out-of-pocket expenses. Ethics committees were reported to be often involved in decision making around reimbursement. Research subject payment practices vary in Australia. Researchers who do provide payments to research participants generally do so without written policy and procedures. Ethics committees have an important role in developing guidelines in this area. Specific guidelines are needed considering existing local policies and procedures; payment models and their application in diverse settings; case study examples of types and levels of reimbursement; applied definitions of incentive and inducement; and the rationale for diverse payment practices in different settings.

  6. Organ preconditioning: the past, current status, and related lung studies

    Institute of Scientific and Technical Information of China (English)

    LUH Shi-ping; YANG Pan-chyr

    2006-01-01

    Preconditioning (PC) has emerged as a powerful method for experimentally and clinically attenuating various types of organ injuries. In this paper related clinical and basic research issues on organ preconditioning issues were systemically reviewed.Since lung injuries, including ischemia-reperfusion and others, play important roles in many clinical results, including thromboembolism, trauma, thermal injury, hypovolemic and endotoxin shock, reimplantation response after organ transplantation, and many respiratory diseases in critical care. It is of interest to uncover methods, including the PCs, to protect the lung from the above injuries. However, related studies on pulmonary PC are relatively rare and still being developed, so we will review previous literature on experimental and clinical studies on pulmonary PC in the following paragraphs.

  7. Fast Food Pattern and Cardiometabolic Disorders: A Review of Current Studies

    OpenAIRE

    Zahra Bahadoran; Parvin Mirmiran; Fereidoun Azizi

    2016-01-01

    Background: There are growing concern globally regarding the alarming trend of fast food consump­tion and its related cardiometabolic outcomes including overweight and obesity. This study aimed to review the current evidences available in relation to adverse effects of fast food pattern on cardiometa­bolic risk factors. Methods: Relevant articles including epidemiological and clinical studies with appropriate design and good quality were obtained through searches of the Medline, PubMed, S...

  8. Fast Food Pattern and Cardiometabolic Disorders: A Review of Current Studies

    OpenAIRE

    Zahra Bahadoran; Parvin Mirmiran; Fereidoun Azizi

    2015-01-01

    Background: There are growing concern globally regarding the alarming trend of fast food consump­tion and its related cardiometabolic outcomes including overweight and obesity. This study aimed to review the current evidences available in relation to adverse effects of fast food pattern on cardiometa­bolic risk factors. Methods: Relevant articles including epidemiological and clinical studies with appropriate design and good quality were obtained through searches of the Medline, PubMed, S...

  9. Extensive ab initio study of the electronic states of BSe radical including spin-orbit coupling

    Science.gov (United States)

    Liu, Siyuan; Zhai, Hongsheng; Liu, Yufang

    2016-06-01

    The internally contracted multi-reference configuration interaction method (MRCI) with Davidson modification and the Douglas-Kroll scalar relativistic correction has been used to calculate the BSe molecule at the level of aug-cc-pV5Z basis set. The calculated electronic states, including 9 doublet and 6 quartet Λ-S states, are correlated to the dissociation limit of B(2Pu) + Se(3Pg) and B(2Pu) + Se(1Dg). The Spin-orbit coupling (SOC) interaction is taken into account via the state interaction approach with the full Breit-Pauli Hamiltonian operator, which causes the entire 15 Λ-S states to split into 32 Ω states. This is the first time that the spin-orbit coupling calculation has been carried out on BSe. The potential energy curves of the Λ-S and Ω electronic states are depicted with the aid of the avoided crossing rule between electronic states of the same symmetry. The spectroscopic constants of the bound Λ-S and Ω states were determined, which are in good agreement with the experimental data. The transition dipole moments (TDMs) and the Franck-Condon factors (FCs) of the transitions from the low-lying bound Ω states A2Π(I)3/2, B2Π(I)1/2 and C2Δ(I)3/2 to the ground state X2Σ+1/2 have also been presented. Based on the previous calculations, the radiative lifetimes of the A2Π(I)3/2, B2Π(I)1/2 and C2Δ(I)3/2 were evaluated.

  10. Recent Advances in Study on Thermodynamic Models for Real Systems Including Electrolytes

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A comprehensive review of recent advances in study on thermodynamic models for real electrolyte solutions is presented. The differences between primitive and non-primitive electrolyte models are demonstrated. Some new thermodynamic models for electrolyte solutions based on the mean spherical approximation and perturbation theory are introduced. An extended scaled-particle theory and modified CleggPitz er equation are presented for physical and chemical absorption processes with mixed solvents, respectively. A pseudo one-component two-Yukawa equation of state is used for the aqueous two-phase extraction process in charged colloidal systems.

  11. A Study of Neutron Star Structure in Strong Magnetic Fields that includes Anomalous Magnetic Moments

    Institute of Scientific and Technical Information of China (English)

    Guang-Jun Mao; Akira Iwamoto; Zhu-Xia Li

    2003-01-01

    We study the effect of strong magnetic fields on the structure of neutronstar. We find that if the interior field is on the same order as the surface fieldcurrently observed, then the influences of the field on the star's mass and radius arenegligible; if the field is as large as that estimated from the scalar virial theorem,then considerable effects will be induced. The maximum mass of the star will beincreased substantially while the central density is greatly reduced. The radius ofa magnetic star can be larger by about 10% ~ 20% than a nonmagnetic star of thesame mass.

  12. A Completeness Study on Certain 2×2 Lax Pairs Including Zero Terms

    Directory of Open Access Journals (Sweden)

    Mike C. Hay

    2011-09-01

    Full Text Available We expand the completeness study instigated in [J. Math. Phys. 50 (2009, 103516, 29 pages] which found all 2×2 Lax pairs with non-zero, separable terms in each entry of each Lax matrix, along with the most general nonlinear systems that can be associated with them. Here we allow some of the terms within the Lax matrices to be zero. We cover all possible Lax pairs of this type and find a new third order equation that can be reduced to special cases of the non-autonomous lattice KdV and lattice modified KdV equations among others.

  13. Alternative oxidizers for strip coal mine blasting agents. [Including study of possible substitutes; 53 references

    Energy Technology Data Exchange (ETDEWEB)

    Sudweeks, W.B.; Collins, T.K.

    1979-03-14

    Since ammonium nitrate manufacture is dependent on natural gas, a shortage in natural gas could lead to a critical shortage in coal by limiting the availability of ammonium nitrate for blasting. The purpose of this study was to assess the future availability of ammonium nitrate and to evaluate the potential of alternative oxidizers not dependent upon natural gas for use in blasting agents. Increased storage capacities and rapidly increasing levels of relativey cheap imported ammonia appear to ensure the availability of adequate levels of ammonium nitrate in the near future. In the longer time frame, rising energy costs have increased the potential for basing ammonia production on alternative sources of hydrogen as well as obtaining natural gas from relatively unlimited unconventional sources. While still somewhat uncertain, such unconventional sources appear to have sufficient potential to ensure the availability of ammonium nitrate even long term. However, there are several oxidizers that could be considered as possible replacements for ammonium nitrate if needed. After a critical evaluation two possible alternatives are recommended for further study: the use of sodium nitrate as a partial replacement and the development of a new type of blasting agent based upon water as the main oxidizer.

  14. Statistically Non-significant Papers in Environmental Health Studies included more Outcome Variables

    Institute of Scientific and Technical Information of China (English)

    Pentti Nieminen; Khaled Abass; Kirsi Vhkanga; Arja Rautio

    2015-01-01

    Objective The number of analyzed outcome variables is important in the statistical analysis and interpretation of research findings. This study investigated published papers in the field of environmental health studies. We aimed to examine whether differences in the number of reported outcome variables exist between papers with non-significant findings compared to those with significant findings. Articles on the maternal exposure to mercury and child development were used as examples. Methods Articles published between 1995 and 2013 focusing on the relationships between maternal exposure to mercury and child development were collected from Medline and Scopus. Results Of 87 extracted papers, 73 used statistical significance testing and 38 (43.7%) of these reported ‘non-significant’ (P>0.05) findings. The median number of child development outcome variables in papers reporting ‘significant’ (n=35) and ‘non-significant’ (n=38) results was 4 versus 7, respectively (Mann-Whitney test P-value=0.014). An elevated number of outcome variables was especially found in papers reporting non-significant associations between maternal mercury and outcomes when mercury was the only analyzed exposure variable. Conclusion Authors often report analyzed health outcome variables based on their P-values rather than on stated primary research questions. Such a practice probably skews the research evidence.

  15. Effect of neurosteroids on a model lipid bilayer including cholesterol: An Atomic Force Microscopy study.

    Science.gov (United States)

    Sacchi, Mattia; Balleza, Daniel; Vena, Giulia; Puia, Giulia; Facci, Paolo; Alessandrini, Andrea

    2015-05-01

    Amphiphilic molecules which have a biological effect on specific membrane proteins, could also affect lipid bilayer properties possibly resulting in a modulation of the overall membrane behavior. In light of this consideration, it is important to study the possible effects of amphiphilic molecule of pharmacological interest on model systems which recapitulate some of the main properties of the biological plasma membranes. In this work we studied the effect of a neurosteroid, Allopregnanolone (3α,5α-tetrahydroprogesterone or Allo), on a model bilayer composed by the ternary lipid mixture DOPC/bSM/chol. We chose ternary mixtures which present, at room temperature, a phase coexistence of liquid ordered (Lo) and liquid disordered (Ld) domains and which reside near to a critical point. We found that Allo, which is able to strongly partition in the lipid bilayer, induces a marked increase in the bilayer area and modifies the relative proportion of the two phases favoring the Ld phase. We also found that the neurosteroid shifts the miscibility temperature to higher values in a way similarly to what happens when the cholesterol concentration is decreased. Interestingly, an isoform of Allo, isoAllopregnanolone (3β,5α-tetrahydroprogesterone or isoAllo), known to inhibit the effects of Allo on GABAA receptors, has an opposite effect on the bilayer properties.

  16. Theoretical study of electronic absorptions in aminopyridines - TCNE CT complexes by quantum chemical methods, including solvent.

    Science.gov (United States)

    Mach, Pavel; Juhász, György; Kyseľ, Ondrej

    2013-11-01

    The geometric and electronic structure of donor-acceptor complexes of TCNE with aniline, o-, m- and p- aminopyridines and pyridine has been studied in gas phase and in solution using CC2, TDDFT and CIS methods. Concerning interaction energy between particular donor and TCNE acceptor it is fairly described by both CC2 (MP2) and DFT-D approaches. Transition energies in gas phase calculated by CC2 approach are in good agreement with available experimental data for aniline. TDDFT calculations with LC-BLYP functional (with standard value of range separation factor μ = 0.47) gives transition energies too high although not as high as CIS. The red solvent shifts, calculated by PCM model with CIS method are qualitative correct, but error in the range of 0.1-0.2 eV should be expected.

  17. Ab initio study of the optical properties of crystalline phenanthrene, including the excitonic effects

    Science.gov (United States)

    Dadsetani, Mehrdad; Nejatipour, Hajar; Ebrahimian, Ali

    2015-05-01

    Using the ab initio methods for solving the Bethe-Salpeter equation on the basis of the FPLAPW method, optical properties of crystalline phenanthrene were calculated, in a comparison to its isomer, anthracene. It was found that despite the similarity of the structural, electronic, and the overall optical properties in a 40 eV energy range, phenanthrene and anthracene show significant differences in their optical spectra in the energy range below band gaps. Phenanthrene has two spin singlet excitonic features whereas anthracene shows one. The singlet and the lowest triplet binding energies of phenanthrene were found to be larger than anthracene. In this study, in addition, a comparison has been made between the optical spectra in RPA and the existing experimental data.

  18. A reliability study on tin based lead free micro joint including intermetallic and void evolution

    Science.gov (United States)

    Feyissa, Frezer Assefa

    In microelectronics soldering to Cu pad lead to formation of two intermetallic structures in the solder -pad interface. The growth of these layers is accompanied by microscopic voids that usually cause reliability concern in the industry. Therefore it is important to understand factors that contribute for the growth of IMC using various combination of reflow time, Sn thickness and aging temperature. Systematic study was conducted on Cu-Sn system to investigate the formation and growth of intermetallic compound (IMC) as well as voiding evolution for different solder thicknesses. The growth of the Cu6Sn5 IMC layer was found to be increasing as the Sn thicknesses increase after reflow while the Cu3Sn layer were decreasing under same conditions. Also after reflow and aging more voiding were shown to occur in the thin solder than thicker one.

  19. Public Management and Administration Studies. Should we Include Marketind in Our Curricula?

    Directory of Open Access Journals (Sweden)

    José L. VÁZQUEZ

    2006-06-01

    Full Text Available As a consequence of continuous adaptation of public institutions to requirements of framing where they perform day by day, Public Management and Administration is behaving once and again as a “reinvented” discipline, aiming a new kind of rational, innovative public entities that focus their activities towards an effective achievement of their intended results and benefits. Concepts such as those of “efficiency”, “effectiveness”, “responsibility”, “organizational culture”, etc. are now not only applied to business disciplines, but also to Public Management and Administration. At this point, Marketing has proved to be an useful subject in PMA curricula, not only being in demand by students and syllabi designers, but also by experts in the public field. However, applying marketing techniques and procedures in the same way as used in private business is clearly nonsense. We must consider a proper “public marketing” or “public sector marketing” development. In this paper we debate on these issues, as well as present an overview into the situation of Spanish public universities offering PMA studies, just when they are facing the Bologna adaptation requirements. As a conclusion, some comments for reflection are suggested.

  20. Meningoencephalitis in cats in Austria: a study of infectious causes, including Encephalitozoon cuniculi.

    Science.gov (United States)

    Künzel, Frank; Rebel-Bauder, Barbara; Kassl, Christine; Leschnik, Michael; Url, Angelika

    2017-02-01

    Objectives Despite comprehensive diagnostics, the aetiology of meningoencephalitis (ME) in cats often remains undetermined. As a result of recently published surveys, Encephalitozoon cuniculi has gained growing importance in cats not only with ocular disorders, but also with central nervous system disease. Therefore, it was hypothesised that E cuniculi may be an underestimated pathogen in the development of feline non-suppurative and/or granulomatous ME. Methods As a first step, histopathological sections of the brain of cats with encephalopathy were retrospectively reviewed to identify cases of granulomatous ME. In a second step, an immunohistochemical screening for detection of E cuniculi was performed in cases with ME of unknown origin. Results In 59/89 (66.3%) cats with ME, an aetiologically relevant pathogen was detected. Forty-three of 89 (48.3%) cats had a diagnosis of feline infectious peritonitis. In 14/89 (15.7%) cats, protozoan cysts were identified and infection with Toxoplasma gondii was confirmed by immunohistochemistry (IHC) in all cases. In 2/89 (2.3%) cats with granulomatous ME, fungal organisms were identified. Thirty of 89 (33.7%) cats with ME of unknown origin that underwent IHC for the detection of E cuniculi remained negative. Conclusions and relevance The results of this study suggest that E cuniculi is unlikely to be directly associated with (non-suppurative and/or granulomatous) ME in cats in Austria.

  1. Results of a Saxitoxin Proficiency Test Including Characterization of Reference Material and Stability Studies

    Directory of Open Access Journals (Sweden)

    Kirsi Harju

    2015-11-01

    Full Text Available A saxitoxin (STX proficiency test (PT was organized as part of the Establishment of Quality Assurance for the Detection of Biological Toxins of Potential Bioterrorism Risk (EQuATox project. The aim of this PT was to provide an evaluation of existing methods and the European laboratories’ capabilities for the analysis of STX and some of its analogues in real samples. Homogenized mussel material and algal cell materials containing paralytic shellfish poisoning (PSP toxins were produced as reference sample matrices. The reference material was characterized using various analytical methods. Acidified algal extract samples at two concentration levels were prepared from a bulk culture of PSP toxins producing dinoflagellate Alexandrium ostenfeldii. The homogeneity and stability of the prepared PT samples were studied and found to be fit-for-purpose. Thereafter, eight STX PT samples were sent to ten participating laboratories from eight countries. The PT offered the participating laboratories the possibility to assess their performance regarding the qualitative and quantitative detection of PSP toxins. Various techniques such as official Association of Official Analytical Chemists (AOAC methods, immunoassays, and liquid chromatography-mass spectrometry were used for sample analyses.

  2. [Cognitive function and its evaluation methods in Parkinson's disease--a study including RCPM and ERP].

    Science.gov (United States)

    Nakazawa, M; Kitamura, S; Nagazumi, A; Terashi, A

    1993-11-01

    In order to investigate features of cognitive impairment in idiopathic Parkinson's disease (PD) and suitable methods for the cognitive evaluation of patients with PD, 23 PD patients and 15 normal control subjects were studied using neuropsychological tests and auditory event-related potential (ERP). The two groups did not differ from each other in age or education. Clinical severity of the patients based on Hoehn & Yahr's staging ranged from stage I to IV: 7 patients at stage I, 8 at stage II, 7 at stage III and 1 at stage IV. All patients achieved the Mini-Mental State test (MMS) scores of 24 or greater, and none of the patients showed middle or serious grade of dementia based on the Diagnostic and Statistical Manual of Mental Disorders-Third edition-Revised (DSM-III-R). All patients and controls underwent MMS, the Hasegawa's Dementia Screening Scale (HDS), the Wechsler Adult Intelligence Scale-Revised (WAIS-R), the Raven's coloured progressive matrices (RCPM), The Wisconsin Card Sorting Test (WCST) and the Benton Visual Retention Test (BVRT). Auditory ERPs by standard oddball paradigm (two-choice reaction time task) were elicited (band-pass 0.1-50 Hz) from Cz electrode sites on all subjects with a random series of binaural 1,000 (standard; 80%) or 2,000 (target; 20%) Hz tones presented every 2 sec at 70 dB SPL. In RCPM, N100 peak latencies of ERP (target and standard), performance-IQ of WAIS-R (especially block design and digit symbol subtests) and in error scores of BVRT there were striking differences between the two groups (p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

  3. Current Conceptual Challenges in the Study of Rhythm Processing Deficits

    Directory of Open Access Journals (Sweden)

    Pauline eTranchant

    2015-06-01

    Full Text Available Interest in the study of rhythm processing deficits (RPD is currently growing in the cognitive neuroscience community, as this type of investigation constitutes a powerful tool for the understanding of normal rhythm processing. Because this field is in its infancy, it still lacks a common conceptual vocabulary to facilitate effective communication between different researchers and research groups. In this commentary, we provide a brief review of recent reports of RPD through the lens of one important empirical issue: the method by which beat perception is measured, and the consequences of method selection for the researcher’s ability to specify which mechanisms are impaired in RPD. This critical reading advocates for the importance of matching measurement tools to the putative neurocognitive mechanisms under study, and reveals the need for effective and specific assessments of the different aspects of rhythm perception and synchronization.

  4. Including health economic analysis in pilot studies: lessons learned from a cost-utility analysis within the PROSPECTIV pilot study

    Directory of Open Access Journals (Sweden)

    Richéal M. Burns

    2017-07-01

    Full Text Available PurposeTo assess feasibility and health economic benefits and costs as part of a pilot study for a nurse-led, psychoeducational intervention (NPLI for prostate cancer in order to understand the potential for cost effectiveness as well as contribute to the design of a larger scale trial.MethodsMen with stable prostate cancer post-treatment were recruited from two cancer centres in the UK. Eighty-three men were randomised to the NLPI plus usual care or usual care alone (UCA (42 NLPI and 41 UCA; the NLPI plus usual care was delivered in the primary-care setting (the intervention and included an initial face-to-face consultation with a trained nurse, with follow-up tailored to individual needs. The study afforded the opportunity to undertake a short-term within pilot analysis. The primary outcome measure for the economic evaluation was quality of life, as measured by the EuroQol five dimensions questionnaire (EQ-5D (EQ-5D-5L instrument. Costs (£2014 assessed included health-service resource use, out-of-pocket expenses and losses from inability to undertake usual activities.ResultsTotal and incremental costs varied across the different scenarios assessed, with mean cost differences ranging from £173 to £346; incremental effect, as measured by the change in utility scores over the duration of follow-up, exhibited wide confidence intervals highlighting inconclusive effectiveness (95% CI: -0.0226; 0.0438. The cost per patient of delivery of the intervention would be reduced if rolled out to a larger patient cohort.ConclusionsThe NLPI is potentially cost saving depending on the scale of delivery; however, the results presented are not considered generalisable.

  5. MIXED FINITE ELEMENT METHODS FOR THE SHALLOW WATER EQUATIONS INCLUDING CURRENT AND SILT SEDIMENTATION (Ⅰ)-THE CONTINUOUS-TIME CASE

    Institute of Scientific and Technical Information of China (English)

    罗振东; 朱江; 曾庆存; 谢正辉

    2004-01-01

    An initial-boundary value problem for shallow equation system consisting of water dynamics equations, silt transport equation, the equation of bottom topography change, and of some boundary and initial conditions is studied, the existence of its generalized solution and semidiscrete mixed finite element (MFE) solution was discussed, and the error estimates of the semidiscrete MFE solution was derived. The error estimates are optimal.

  6. CURRENT STUDY ON THE FUNDING SOURCES COVERAGE OF CURRENT ASSETS TO COMPANIES LISTED ON THE BUCHAREST STOCK EXCHANGE

    Directory of Open Access Journals (Sweden)

    Teodor HADA

    2014-06-01

    Full Text Available This paper presents issues about the coverage with financing sources of current assets for 64 companies listed on the Bucharest Stock Exchange. The aim of the study is to see how to calculate indicators specific to current assets and the general framework offered as whole analysis of the financing sources of current assets. The introduction of the paper presents the objective, the research methodology and the novelties brought by this study. Further on, this study shows the various views of the authors about the concept of "current assets", financing sources of current assets, the calculation of net working capital, setting the limits of the normal working capital and determining the speed of rotation. After that was done, based on the theory, a case study was performed, for companies covered in this study. Conclusions focused on determining the final data about what was detailed in the previous paragraphs.

  7. Site Selection for the European ELT: working package included in the European FP6 ``ELT design study'' contract

    Science.gov (United States)

    Muñoz-Tuñón, C.; Sarazin, M.; Vernin, J.

    2007-10-01

    The site selection for the future European Large Telescope (E-ELT) is a key issue within the European proposal funded by the European Union (EU), within the ``ELT design study'' proposal. The organization, working scheme and baseline frameworks are reviewed. For the definition of the working package WP12000 ``Site Characterization'', important use has been done of previous work in the definition of techniques and tools for the study of the atmosphere above observing sites. We have also taken advantage of the number of data already available which have naturally defined a ranking among the known places which have also been taken as a base line for pre-selecting the candidate sites. The work will last 4 years, it started in 2005 and is organized in subtasks, working packages WP, whose main objectives are the following: WP12100: to characterize two top astronomical sites (ORM and North-Paranal) and to explore three other alternatives (Macon in Argentina, Izaña in Spain and Aklim in Morocco) suitable to install an ELT under the best conditions (Dome C is been currently under investigation, and no particular effort will be put in this site, but rather its atmospheric properties will be compared to the above mentioned sites). WP12200 is dedicated to design, build and operate a set of standard equipment in all the sites and to perform long term campaign. WP12300 will investigate wavefront properties over large baselines (50-100 m) corresponding to the size of the future ELT, as well as the fine characterization of the optical turbulence within the boundary layer. A similar plan is being carried out by the Thirty Meter Telescope (TMT) site selection team. For the sake of saving resources (budget and people), the TMT preselected sites (all in the American Continent) are not included in our European study.

  8. Experimental study of blockage of monochromatic waves by counter currents

    NARCIS (Netherlands)

    Suastika, I.K.

    1999-01-01

    Blockage of waves by a current can occur if waves are propagating on a spatially varying opposing current in which the velocity is increasing in the wave propagation direction. The ongoing waves become shorter and steeper while they are propagating against the current. Blocking occurs at the

  9. Optical timing studies of isolated neutron stars: Current Status

    CERN Document Server

    Mignani, R P

    2010-01-01

    Being fast rotating objects, Isolated Neutron Stars (INSs) are natural targets for high-time resolution observations across the whole electromagnetic spectrum. With the number of objects detected at optical (plus ultraviolet and infrared) wavelengths now increased to 24, high-time resolution observations of INSs at these wavelengths are becoming more and more important. While classical rotation-powered radio pulsars, like the Crab and Vela pulsars, have been the first INSs studied at high-time resolution in the optical domain, observations performed in the last two decades have unveiled potential targets in other types of INSs which are not rotation powered, although their periodic variability is still related to the neutron star rotation. In this paper I review the current status of high-time resolution observations of INSs in the optical domain for different classes of objects: rotation-powered pulsars, magnetars, thermally emitting neutron stars, and rapid radio transients, I describe their timing properti...

  10. Numerical Study on the Bifurcation of the North Equatorial Current

    Institute of Scientific and Technical Information of China (English)

    LIU Yulong; WANG Qi; SONG Jun; ZHU Xiande; GONG Xiaoqing; WU Fang

    2011-01-01

    A 1.5-layer reduced-gravity model forced by wind stress is used to study the bifurcations of the North Equatorial Current (NEC).The authors found that after removing the Ekman drift,the modelled circulations can serve well as a proxy of the SODA circulations on the σθ=25.0kgm-3 potential density surface based on available long-term reanalysis wind stress data.The modelled results show that the location of the western boundary bifurcation of the NEC depends on both zonal averaged and local zero wind stress curl latitude.The effects of the anomalous wind stress curl added in different areas are also investigated and it is found that they can change the strength of the Mindanao Eddy (ME),and then influence the interior pathway.

  11. Psychological factors, including alexithymia, in the prediction of cardiovascular risk in HIV infected patients: results of a cohort study.

    Directory of Open Access Journals (Sweden)

    Giustino Parruti

    Full Text Available BACKGROUND: Psychological factors are known predictors of cardiovascular disease in many clinical settings, but data are lacking for HIV infection. We carried out a prospective cohort study to evaluate potential psychological predictors of preclinical and clinical vascular disease in HIV patients. METHODOLOGY/PRINCIPAL FINDINGS: HIV patients were consecutively enrolled. Demographics, viral and immune parameters and traditional cardiovascular predictors were considered; Intima-Media Thickness (c-IMT, continuous measure and Carotid Plaques (CPs, focal thickening ≥1.5 mm were investigated by B-mode ultrasonography; depressive symptoms by the Beck Depression Inventory (BDI-II, Type D personality (Distressed Personality or Type D by the DS14, alexithymia by the Toronto Alexithymia Scale (TAS-20. Vascular outcomes included transient ischemic attacks or stroke, acute coronary syndrome, myocardial or other organ infarction. We enrolled 232 HIV subjects, 73.9% males, aged 44.5±9.9 y, 38.2% with AIDS diagnosis, 18.3% untreated. Mean Nadir CD4 T-cell counts were 237.5±186.2/mmc. Of them, 224 (96.5% attended IMT measurements; 201 (86.6% attended both IMT assessment and psychological profiling. Mean follow-up was 782±308 days. Fifty-nine patients (29.4% had CPs at baseline. Nineteen patients (9.5% had ≥1 vascular event; 12 (6.0% died due to such events (n = 4 or any cause. At baseline cross-sectional multivariate analysis, increasing age, total cholesterol, current smoking and Alexithymia score≥50 were significantly associated with both increased cIMT (linear regression and CPs (logistic regression. At follow-up analysis, log-rank tests and Cox's regression revealed that only older age (p = 0.001, current smoking (p = 0.019 and alexithymia score≥50 (p = 0.013 were independently associated with vascular events. CONCLUSIONS/SIGNIFICANCE: In HIV-infected subjects, the Alexithymic trait emerges as a strong predictor of increased IMT, presence of CPs

  12. An overview of the causes of current practices in Pratinidhi Dravyas (substitution of drugs) in Ayurveda including newer techniques for their evaluation.

    Science.gov (United States)

    Joshi, Pravin R; Patel, Bhupesh R; Shukla, Vinay J

    2012-10-01

    Many Pratinidhi Dravyas in Ayurvedic classics are mentioned and certainly are based on a methodical approach, which involves many aspects. These principles on which Pratinidhis were decided are quoted nowhere; so both to understand the established Pratinidhis and to find new ones a rational approach is the need of the hour. This article is an effort in the direction to study this concept meticulously in light of modern techniques for its better understanding and application. As there are very few established parameters, which help for selection and evaluation of Pratinidhi Dravyas. A rational technique like Fourier transform infrared spectroscopy may be incorporated to set a new dimension. As most of the routine analytical techniques are separation based, overall component load cannot be predicted. Thus, it is prime necessity to compare the drugs with a whole aspect, which goes in hand by hand with a holistic approach of Ayurveda "Treat the man as Whole - Take the drug as whole."

  13. Multimodal Study of Adult-Infant Interaction: A Review of Its Origins and Its Current Status

    Directory of Open Access Journals (Sweden)

    Soledad Carretero Pérez

    Full Text Available Abstract An interpretative review of research on adult-infant interactions involving the analysis of movement behaviors is presented, systematically linking previous studies to current research on the subject. Forty-two articles analyzing the dyad's interactive movement in the period 1970-2015 were found. Twelve papers were excluded, including only those that studied the phenomenon in the baby's first year of life. The results revealed that movement was a central topic in early interaction studies in the 70s. In the 1980's and 1990's, its study was marginal and it is currently resurging under the embodiment perspective. The conceptual framework and research methods used in the pioneering work are presented, and the thematic foci shared with current research are highlighted. Thus, essential keys are provided for the updated study of early interactions from a multimodal perspective.

  14. Experimental Study on Current-Driven Domain Wall Motion

    Science.gov (United States)

    Ono, T.; Yamaguchi, A.; Tanigawa, H.; Yano, K.; Kasai, S.

    2006-06-01

    Current-driven domain wall (DW) motion for a well-defined single DW in a micro-fabricated magnetic wire with submicron width was investigated by real-space observation with magnetic force microscopy. Magnetic force microscopy visualizes that a single DW introduced in a wire is displaced back and forth by positive and negative pulsed-current, respectively. Effect of the Joule heating, reduction of the threshold current density by shape control, and magnetic ratchet effect are also presented.

  15. Study of toroidal current penetration during current ramp in JIPP T-IIU with fast response Zeeman polarimeter

    Energy Technology Data Exchange (ETDEWEB)

    Kuramoto, H.; Hiraki, N. [Kyushu Inst. of Tech., Kitakyushu, Fukuoka (Japan); Toi, K. [and others

    1997-01-01

    The toroidal current penetration is studied in current ramp experiments of the JIPP T-IIU tokamak. The poloidal magnetic field profile in the peripheral region of a plasma (0.5 {<=} {rho} {<=} 1.0) has been measured directly with a newly developed fast response Zeeman polarimeter. The experimental results indicate that an obvious skin effect of toroidal current density is clearly observed during both the current ramp-up and ramp-down experiments. The experimentally obtained toroidal current density profiles are well described by the profiles calculated on the assumption of the neoclassical electrical conductivity. Quasi-linear {Delta}`-analysis of tearing modes for the measured current density profile is consistent with time behaviour of coherent MHD modes such as m=4/n=1 or m=3/n=1 (m: poloidal mode number, n: toroidal mode number) often observed during the current ramp-up phase. The effect of these MHD modes on current penetration during the current ramp-up discharges is studied. (author)

  16. Current state of the hydrothermal geochemistry studies at Cerro Prieto

    Energy Technology Data Exchange (ETDEWEB)

    Fausto L, J.J.; Jimenez S, M.E.; Esquer P, I.

    1981-01-01

    The current state of hydrothermal geochemistry studies being carried out at the field are reported. These studies are based on the results of chemical analysis of water samples collected during 1979 and 1980 at the geothermal wells of the area known as Cerro Prieto I, as well as from those located in the Cerro Prieto II and Cerro Prieto III areas, some of which have only recently started flowing. Data are presented on the chemical variations of the main chemical constituents dissolved in the waters, as well as on the Na/K and Na-K-Ca chemical relations and the temperatures calculated from them and from SiO/sub 2/. Fluid recharge into the reservoir and its direction of flow are interpreted from isotherm contour maps of the field prepared from Na/K and Na-K-Ca geothermometry and from concentration contour maps of some of the main chemical constituents. Well M-43 is discussed as an example of a well affected by well completion problems in its production casing. Its behavior is explained on the basis of the chemical characteristics of the produced water. The chemical changes that have taken place in some of the wells during production are explained by correlating the chemistry with the production mechanisms of the well (steam-water production rates).

  17. Ethical implications of including children in a large biobank for genetic-epidemiologic research: a qualitative study of public opinion.

    Science.gov (United States)

    Kaufman, David; Geller, Gail; Leroy, Lisa; Murphy, Juli; Scott, Joan; Hudson, Kathy

    2008-02-15

    The National Institutes of Health and other federal agencies are considering initiating a cohort study of 500,000 people, including 120,000 children, to measure genetic and environmental influences on common diseases. A community engagement pilot study was conducted to identify public attitudes and concerns about the proposed cohort study, including the ethics of involving children. The pilot included 15 focus groups where the inclusion of children in the proposed cohort study was discussed. Focus groups, conducted in six cities, included 141 adults of different ages, incomes, genders, ethnicities, and races. Many of the concerns expressed by participants mirrored those addressed in pediatric research guidelines. These concerns included minimizing children's fear, pain, and burdens; whether to include young children; and how to obtain children's assent. There was little agreement about which children can assent. Some voiced concern about children's privacy, but most expected that parents would have access to children's study results. Some believed children would not benefit from participating, while others identified personal and societal benefits that might accrue. A few people believed that children's participation would not advance the study's goals. To successfully include children, proposed cohort study would need to address children's changing capabilities and rights as they grow and reach the age of consent.

  18. Particle Image Velocimetry Study of Density Current Fronts

    Science.gov (United States)

    Martin, Juan Ezequiel

    2009-01-01

    Gravity currents are flows that occur when a horizontal density difference causes fluid to move under the action of gravity; density currents are a particular case, for which the scalar causing the density difference is conserved. Flows with a strong effect of the horizontal density difference, even if only partially driven by it--such as the…

  19. Study on electrical current variations in electromembrane extraction process: Relation between extraction recovery and magnitude of electrical current.

    Science.gov (United States)

    Rahmani, Turaj; Rahimi, Atyeh; Nojavan, Saeed

    2016-01-15

    This contribution presents an experimental approach to improve analytical performance of electromembrane extraction (EME) procedure, which is based on the scrutiny of current pattern under different extraction conditions such as using different organic solvents as supported liquid membrane, electrical potentials, pH values of donor and acceptor phases, variable extraction times, temperatures, stirring rates, different hollow fiber lengths and the addition of salts or organic solvents to the sample matrix. In this study, four basic drugs with different polarities were extracted under different conditions with the corresponding electrical current patterns compared against extraction recoveries. The extraction process was demonstrated in terms of EME-HPLC analyses of selected basic drugs. Comparing the obtained extraction recoveries with the electrical current patterns, most cases exhibited minimum recovery and repeatability at the highest investigated magnitude of electrical current. . It was further found that identical current patterns are associated with repeated extraction efficiencies. In other words, the pattern should be repeated for a successful extraction. The results showed completely different electrical currents under different extraction conditions, so that all variable parameters have contributions into the electrical current pattern. Finally, the current patterns of extractions from wastewater, plasma and urine samples were demonstrated. The results indicated an increase in the electrical current when extracting from complex matrices; this was seen to decrease the extraction efficiency.

  20. Thermally stimulated depolarization current studies of sulfonated polystyrene ionomers

    Science.gov (United States)

    Carvalho, Antonio José Felix; Viana, Vicente Galber Freitas; Faria, Roberto Mendonça

    2009-12-01

    A detailed study of thermally stimulated depolarization current (TSDC) was carried out to investigate dipolar relaxation and the charge storage phenomenon in films of sulfonated polystyrene (SPS) ionomers having lithium or potassium as counterions. Differential scanning calorimetry measurements were also applied as a complementary technique, mainly to follow the change of the glass transition temperature with the amount of sulfonated groups. It was observed that, since the glass transition does not change significantly with the amount of sulfonated groups, a cluster of multiplets is expected not to be formed in the range used in this work. TSDC of SPS samples polarized at temperatures higher than the glass transition temperature showed three peaks: one at lower temperature (peak β), an intermediate peak (peak α), and a third that appeared at a temperature coincident with the polarization temperature (peak ρ). Quantitative information about trapping-detrapping and dipolar relaxation and their corresponding activation energies was determined by fittings of the deconvoluted peaks with kinetic relaxation processes.

  1. Thermally stimulated depolarization current studies of sulfonated polystyrene ionomers

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Antonio Jose Felix [Universidade Federal de Sao Carlos, Laboratory of Polymers and Renewable Materials, Sorocaba, SP (Brazil); Viana, Vicente Galber Freitas [Universidade Federal do Piaui, Centro de Ciencias da Natureza, Teresina, PI (Brazil); Faria, Roberto Mendonca [USP, Instituto de Fisica de Sao Carlos, SP (Brazil)

    2009-12-15

    A detailed study of thermally stimulated depolarization current (TSDC) was carried out to investigate dipolar relaxation and the charge storage phenomenon in films of sulfonated polystyrene (SPS) ionomers having lithium or potassium as counterions. Differential scanning calorimetry measurements were also applied as a complementary technique, mainly to follow the change of the glass transition temperature with the amount of sulfonated groups. It was observed that, since the glass transition does not change significantly with the amount of sulfonated groups, a cluster of multiplets is expected not to be formed in the range used in this work. TSDC of SPS samples polarized at temperatures higher than the glass transition temperature showed three peaks: one at lower temperature (peak {beta}), an intermediate peak (peak {alpha}), and a third that appeared at a temperature coincident with the polarization temperature (peak {rho}). Quantitative information about trapping-detrapping and dipolar relaxation and their corresponding activation energies was determined by fittings of the deconvoluted peaks with kinetic relaxation processes. (orig.)

  2. Perspective of the study on the ring current - past, present and future

    Science.gov (United States)

    Ebihara, Y.

    2016-12-01

    The study of the ring current has a long history going back to the early 20th century. The ring current was predicted by Carl Stoermer to explain the equatorward movement of the auroral zone during magnetic storms. In 1917, Adolf Schmidt introduced the concept of the ring current to explain the global decrease of the geomagnetic field. Since then, number of studies have been accomplished in the context of the growth and recovery of magnetic storms. Observations have shown that protons and oxygen ions with energies 1 - 100 keV significantly increase during the storm main phase, which are most likely the major contributor to the storm-time ring current. When the loss of the ions dominates the injection of them, the storm recovery phase takes place. Immediate problems are the origin, transport and loss of the ions. All these relevant processes are essential to understand the growth and decay of the ring current. Derived problems, for example, include the entry of solar wind plasma into the magnetosphere, the outflow of ionospheric ions, generation of the convection electric field, influence of substorm-associated electric field, and pitch angle scattering of ions. Recalling that the ring current is the diamagnetic current, we shall consider the force balance and stress carefully. Generation of field-aligned currents is one of the consequences, which might redistribute the state of the inner magnetosphere including the plasmasphere, the ring current and the radiation belts. The ring current may also have a large influence on the geomagnetically induced current (GIC) on the ground at mid- and low-latitudes. The magnetic storms can be easily identified by looking at magnetograms, but the processes behind the magnetic storms cannot be easily understood because the processes depend on each other. From this sense, we shall pay much attention to the detailed function of each process as well as its role on the overall system. Dealing with the ring current as a complex system

  3. MODEL STUDY OF THE DOUBLE FED MACHINE WITH CURRENT CONTROL

    Directory of Open Access Journals (Sweden)

    A. S. Lyapin

    2016-07-01

    Full Text Available The paper deals with modeling results of the double fed induction machine with current control in the rotor circuit. We show the most promising applications of electric drives on the basis of the double fed induction machine and their advantages. We present and consider functional scheme of the electric drive on the basis of the double fed induction machine with current control. Equations are obtained for creation of such machine mathematical model. Expressions for vector projections of rotor current are given. According to the obtained results, the change of the vector projections of rotor current ensures operation of the double fed induction machine with the specified values of active and reactive stator power throughout the variation range of sliding motion. We consider static characteristics of double fed machine with current control. Energy processes proceeding in the machine are analyzed. We confirm the operationpossibility of double fed induction machine with current controlin the rotor circuit with given values of active and reactive stator power. The presented results can be used for creation of mathematical models and static characteristics of double fed machines with current control of various capacities.

  4. Transcranial direct current stimulation in the recovery of postural control after stroke : a pilot study

    OpenAIRE

    Saeys, Wim; Vereeck, Luc; Lafosse, Christophe; Truijen, Steven; Wuyts, Floris L.; de Heyning, van, P.H.

    2015-01-01

    Abstract: Purpose: This pilot study aimed to evaluate the effectiveness of multiple sessions of transcranial Direct Current Stimulation (tDCS) during 4 weeks on balance and gait parameters after stroke. Method: Thirty-one stroke patients were included in this randomised, double-blind, sham-controlled crossover study. The Tinetti test was used to assess functional balance and gait after stroke. Secondary measures, Rivermead Motor Assessment (RMA) and Trunk Impairment Scale (TIS), were register...

  5. Study of wavelet transform type high-current transformer

    Institute of Scientific and Technical Information of China (English)

    卢文科; 朱长纯; 刘君华; 张建军

    2002-01-01

    The wavelet transformation is applied to the high-current transformer.The high-current transformer elaborated in the paper is mainly applied to the measurement of AC/DC high-current.The principle of the transformer is the Hall direct-measurement principle.The transformer has the following three characteristics:firstly, the effect of the remnant field of the iron core on the measurement is decreased;secondly,because the temperature compensation is adopted,the transformer has good temperature charactreristic;thirdly,be-cause the wavelet transfomation technology is adopted,the transformer has the capacity of good antijanming.

  6. Cost-of-illness studies : a review of current methods.

    Science.gov (United States)

    Akobundu, Ebere; Ju, Jing; Blatt, Lisa; Mullins, C Daniel

    2006-01-01

    The number of cost-of-illness (COI) studies has expanded considerably over time. One outcome of this growth is that the reported COI estimates are inconsistent across studies, thereby raising concerns over the validity of the estimates and methods. Several factors have been identified in the literature as reasons for the observed variation in COI estimates. To date, the variation in the methods used to calculate costs has not been examined in great detail even though the variations in methods are a major driver of variation in COI estimates. The objective of this review was to document the variation in the methodologies employed in COI studies and to highlight the benefits and limitations of these methods. The review of COI studies was implemented following a four-step procedure: (i) a structured literature search of MEDLINE, JSTOR and EconLit; (ii) a review of abstracts using pre-defined inclusion and exclusion criteria; (iii) a full-text review using pre-defined inclusion and exclusion criteria; and (iv) classification of articles according to the methods used to calculate costs. This review identified four COI estimation methods (Sum_All Medical, Sum_Diagnosis Specific, Matched Control and Regression) that were used in categorising articles. Also, six components of direct medical costs and five components of indirect/non-medical costs were identified and used in categorising articles.365 full-length articles were reflected in the current review following the structured literature search. The top five cost components were emergency room/inpatient hospital costs, outpatient physician costs, drug costs, productivity losses and laboratory costs. The dominant method, Sum_Diagnosis Specific, was a total costing approach that restricted the summation of medical expenditures to those related to a diagnosis of the disease of interest. There was considerable variation in the methods used within disease subcategories. In several disease subcategories (e.g. asthma, dementia

  7. Study on UPF Harmonic Current Detection Method Based on DSP

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, H J [Northwestern Polytechnical University, Xi' an 710072 (China); Pang, Y F [Xi' an University of Technology, Xi' an 710048 (China); Qiu, Z M [Xi' an University of Technology, Xi' an 710048 (China); Chen, M [Northwestern Polytechnical University, Xi' an 710072 (China)

    2006-10-15

    Unity power factor (UPF) harmonic current detection method applied to active power filter (APF) is presented in this paper. The intention of this method is to make nonlinear loads and active power filter in parallel to be an equivalent resistance. So after compensation, source current is sinusoidal, and has the same shape of source voltage. Meanwhile, there is no harmonic in source current, and the power factor becomes one. The mathematic model of proposed method and the optimum project for equivalent low pass filter in measurement are presented. Finally, the proposed detection method applied to a shunt active power filter experimental prototype based on DSP TMS320F2812 is developed. Simulation and experiment results indicate the method is simple and easy to implement, and can obtain the real-time calculation of harmonic current exactly.

  8. Durability Study of SOFCs Under Cycling Current Load Conditions

    DEFF Research Database (Denmark)

    Hagen, Anke; Hendriksen, Peter Vang; Frandsen, Henrik Lund;

    2009-01-01

    In fuel cell applications, the cells must be able to withstand varying operating conditions. Anode supported solid oxide fuel cells were tested under cycling current load in order to determine the durability and possibly identify degradation mechanisms. At 750 °C and a cycling between zero and 0.......75 A cm-2, the cell voltage degradation rate was similar to tests with the corresponding high constant current density. However, by analyzing the impedance spectra it was found that anode degradation was becoming more important when going from constant to cycling conditions. Running the cycling load tests...... at 850 °C, the cells degraded similarly as under the corresponding constant current load whereas, in some cases, cells failed mechanically after a few hundred hours. These cells did not experience severe additional degradation due to the cycling of the current density until the point of failure...

  9. Study of lower hybrid current drive for the demonstration reactor

    Energy Technology Data Exchange (ETDEWEB)

    Molavi-Choobini, Ali Asghar [Dept. of Physics, Faculty of Engineering, Islamic Azad University, Shahr-e-kord Branch, Shahr-e-kord (Iran, Islamic Republic of); Naghidokht, Ahmed [Dept. of Physics, Urmia University, Urmia (Iran, Islamic Republic of); Karami, Zahra [Dept. of Engineering, Islamic Azad University, Zanjan Branch, Zanjan (Iran, Islamic Republic of)

    2016-06-15

    Steady-state operation of a fusion power plant requires external current drive to minimize the power requirements, and a high fraction of bootstrap current is required. One of the external sources for current drive is lower hybrid current drive, which has been widely applied in many tokamaks. Here, using lower hybrid simulation code, we calculate electron distribution function, electron currents and phase velocity changes for two options of demonstration reactor at the launched lower hybrid wave frequency 5 GHz. Two plasma scenarios pertaining to two different demonstration reactor options, known as pulsed (Option 1) and steady-state (Option 2) models, have been analyzed. We perceive that electron currents have major peaks near the edge of plasma for both options but with higher efficiency for Option 1, although we have access to wider, more peripheral regions for Option 2. Regarding the electron distribution function, major perturbations are at positive velocities for both options for flux surface 16 and at negative velocities for both options for flux surface 64.

  10. A EUropean study on effectiveness and sustainability of current Cardiac Rehabilitation programmes in the Elderly

    DEFF Research Database (Denmark)

    Prescott, Eva; Meindersma, Esther P; van der Velde, Astrid E

    2016-01-01

    on effectiveness and sustainability of current cardiac rehabilitation programmes in the elderly (EU-CaRE) project consists of an observational study and an open prospective, investigator-initiated multicentre randomised controlled trial (RCT) involving mobile telemonitoring guided CR (mCR). OBJECTIVE: The aim...... of EU-CaRE is to map the efficiency of current CR of the elderly in Europe, and to investigate whether mCR is an effective alternative in terms of efficacy, adherence and sustainability. METHODS AND RESULTS: The EU-CaRE study includes patients aged 65 years or older with ischaemic heart disease or who...... home-based programme while the control group will receive no advice or coaching throughout the study period. Outcomes will be assessed after the end of CR and at 12 months follow-up. The primary outcome is VO2peak and secondary outcomes include variables describing CR uptake, adherence, efficacy...

  11. Animal venom studies: Current benefits and future developments

    Institute of Scientific and Technical Information of China (English)

    Yuri; N; Utkin

    2015-01-01

    Poisonous organisms are represented in many taxa, including kingdom Animalia. During evolution, animals have developed special organs for production and injection of venoms. Animal venoms are complex mixtures, compositions of which depend on species producing venom. The most known and studied poisonous terrestrial animals are snakes, scorpions and spiders. Among marine animals, these are jellyfishes, anemones and cone snails. The toxic substances in the venom ofthese animals are mainly of protein and peptide origin. Recent studies have indicated that the single venom may contain up to several hundred different components producing diverse physiological effects. Bites or stings by certain poisonous species result in severe envenomations leading in some cases to death. This raises the problem of bite treatment. The most effective treatment so far is the application of antivenoms. To enhance the effectiveness of such treatments, the knowledge of venom composition is needed. On the other hand, venoms contain substances with unique biological properties, which can be used both in basic science and in clinical applications. The best example of toxin application in basic science is α-bungarotoxin the discovery of which made a big impact on the studies of nicotinic acetylcholine receptor. Today compositions of venom from many species have already been examined. Based on these data, one can conclude that venoms contain a large number of individual components belonging to a limited number of structural types. Often minor changes in the amino acid sequence give rise to new biological properties. Change in the living conditions of poisonous animals lead to alterations in the composition of venoms resulting in appearance of new toxins. At the same time introduction of new methods of proteomics and genomics lead to discoveries of new compounds, which may serve as research tools or as templates for the development of novel drugs. The application of these sensitive and

  12. A Descriptive Study on the Neonatal Morbidity Profile of Autism Spectrum Disorders, Including a Comparison with Other Neurodevelopmental Disorders

    Science.gov (United States)

    Atladóttir, H. Ó.; Schendel, D. E.; Parner, E. T.; Henriksen, T. B.

    2015-01-01

    The aim of this study was to describe the profile of specific neonatal morbidities in children later diagnosed with autism spectrum disorder (ASD), and to compare this profile with the profile of children with hyperkinetic disorder, cerebral palsy, epilepsy or intellectual disability. This is a Danish population based cohort study, including all…

  13. Checklists of Methodological Issues for Review Authors to Consider When Including Non-Randomized Studies in Systematic Reviews

    Science.gov (United States)

    Wells, George A.; Shea, Beverley; Higgins, Julian P. T.; Sterne, Jonathan; Tugwell, Peter; Reeves, Barnaby C.

    2013-01-01

    Background: There is increasing interest from review authors about including non-randomized studies (NRS) in their systematic reviews of health care interventions. This series from the Ottawa Non-Randomized Studies Workshop consists of six papers identifying methodological issues when doing this. Aim: To format the guidance from the preceding…

  14. Sea otter studies on Amchitka Island 27 July to 5 October 1955 including studies on captive otters in Seattle

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — During our stay on Amchitka we had three primary objectives: 1. To study otters in their natural environment with the purpose of learning more about feeding habits,...

  15. Methodology for electrical studies in industrial networks including the study of electric arc; Metodologia para los estudios electricos en redes industriales incluyendo el estudio de arco electrico

    Energy Technology Data Exchange (ETDEWEB)

    Rasgado Casique, Jose Pepe; Silva Farias, Jose Luis [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)]. E-mail: jrasgado@iie.org.mx; jlsilva@iie.org.mx

    2010-11-15

    This article presents a methodology for conducting electrical studies in industrial networks. The methodology included the study of arc flash as a very important area of current basic electrical studies, such as power flow, short circuit and coordination. The aim of this study is to determine the Personal Protective Equipment (PPE) and flash protection boundary for personnel working with or near energized equipment, based on the IEEE Std 1584-2004 and NFPA-70E- 2004. Also included are criteria and recommendations to reduce incident energy level (cal/cm{sup 2}). At work we used a distribution network for industrial type test. The studies were carried out using a commercial program for the analysis of electrical networks. [Spanish] En este articulo se presenta una metodologia para llevar a cabo los estudios electricos en redes industriales. En la metodologia se incluye al estudio de arco electrico como un area muy importante de los estudios electricos basicos actuales, como: flujos de potencia, cortocircuito y coordinacion de protecciones. El objetivo de dicho estudio es determinar el Equipo de Proteccion Personal (EPP) apropiado y los limites de proteccion para el personal que opera con o cerca de equipo energizado, con base en las normas IEEE Std. 1584-2004 y la NFPA-70E-2004. Ademas, se incluyen criterios y recomendaciones para disminuir el nivel de energia incidente (cal/cm{sup 2}). En el trabajo se utilizo una red de distribucion tipo industrial de prueba. Los estudios se llevaron a cabo utilizando un programa comercial para el analisis de redes electricas.

  16. Current methods for studying dynamic processes in the ionosphere. Sovremennye metody issledovaniia dinamicheskikh protsessov v ionosfere

    Energy Technology Data Exchange (ETDEWEB)

    Filipp, N.D.; Blaunshtein, N.SH.; Erukhimov, L.M.; Ivanov, V.A.; Uriadov, V.P.

    1991-01-01

    Current experimental and theoretical data relevant to the study of dynamic processes in the ionospheric plasma using state-of-the-art methods are summarized. The methods used include linear FM sounding, partial radio wave reflection, oblique-incidence radio wave scattering, radio wave heating of the ionosphere, plasma injection, and computer simulation of physical processes. For each specific method, experimental data are compared against theoretical predictions and numerical calculations. 251 refs.

  17. Zinc electrowinning: anode conditioning and current distribution studies

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, J.A. [Cominco Research, Cominco Ltd., Trail, British Columbia (Canada)

    2001-07-01

    In the zinc electrowinning (EW) process, Pb-Ag anodes are widely used. Prior to their use in the EW process, anodes are conditioned to form a stable oxide layer that can evolve O{sub 2} without excessive Pb contamination of the cathode and MnO{sub 2} precipitation. The most widely used conditioning techniques are: passivation in a KF-H{sub 2}SO{sub 4} electrolysis bath, chemical oxidation in a KMnO{sub 4}-H{sub 2}SO{sub 4} solution, and sandblasting. In this paper, a comparison of these treatments using flat and corrugated anodes is presented. Laboratory and industrial-scale tests carried out at Cominco's Trail and Cajamarquilla zinc plants indicated that flat anodes should be sandblasted or electrochemically passivated before their use in the Zn electrowinning process. Further, corrugated anodes should be sandblasted or chemically conditioned in a KMnO{sub 4}-H{sub 2}SO{sub 4} -electrolyte. The beneficial effects of chemical conditioning are lost if the anode is non-corrugated. Flat, chemically conditioned anodes generate up to 10 times more mud than corrugated-chemically conditioned anodes. Because anode mud growth is evenly distributed on sandblasted anodes, short-circuit frequency may decrease and anode life may increase. Sandblasting does not appear to affect anode performance. Parallel to the industrial anode conditioning tests, current distribution measurements were made. Current flow measurements were used to correct troublesome electrodes and/or bad electrical contacts. In Cajamarquilla, this technique was used in four industrial electrowinning cells and energy consumption values lower than 3000 kWh/t Zn were obtained at current efficiencies as high as 95% and at current densities up to 450 A/m{sup 2}. (author)

  18. Value of the small cohort study including a physical examination for minor structural defects in identifying new human teratogens.

    Science.gov (United States)

    Chambers, Christina D

    2011-03-01

    Most known human teratogens are associated with a unique or characteristic pattern of major and minor malformations and this pattern helps to establish the causal link between the teratogenic exposure and the outcome. Although traditional case-control and cohort study designs can help identify potential teratogens, there is an important role for small cohort studies that include a dysmorphological examination of exposed and unexposed infants for minor structural defects. In combination with other study design approaches, the small cohort study with a specialized physical examination fulfills a necessary function in screening for new potential teratogens and can help to better delineate the spectrum and magnitude of risk for known teratogens.

  19. Study Modules for Calculus-Based General Physics. [Includes Modules 24-26: Electric Potential; Ohm's Law; and Capacitors].

    Science.gov (United States)

    Fuller, Robert G., Ed.; And Others

    This is part of a series of 42 Calculus Based Physics (CBP) modules totaling about 1,000 pages. The modules include study guides, practice tests, and mastery tests for a full-year individualized course in calculus-based physics based on the Personalized System of Instruction (PSI). The units are not intended to be used without outside materials;…

  20. Experiences of Students with Specific Learning Disorder (Including ADHD) in Online College Degree Programs: A Phenomenological Study

    Science.gov (United States)

    Bunch, Seleta LeAnn

    2016-01-01

    Enrollment in online degree programs is rapidly expanding due to the convenience and affordability offered to students and improvements in technology. The purpose of this hermeneutical phenomenological study was to understand the shared experiences of students with documented specific learning disorders (including Attention-Deficit/Hyperactivity…

  1. Extent of non-publication in cohorts of studies approved by research ethics committees or included in trial registries.

    Directory of Open Access Journals (Sweden)

    Christine Schmucker

    Full Text Available BACKGROUND: The synthesis of published research in systematic reviews is essential when providing evidence to inform clinical and health policy decision-making. However, the validity of systematic reviews is threatened if journal publications represent a biased selection of all studies that have been conducted (dissemination bias. To investigate the extent of dissemination bias we conducted a systematic review that determined the proportion of studies published as peer-reviewed journal articles and investigated factors associated with full publication in cohorts of studies (i approved by research ethics committees (RECs or (ii included in trial registries. METHODS AND FINDINGS: Four bibliographic databases were searched for methodological research projects (MRPs without limitations for publication year, language or study location. The searches were supplemented by handsearching the references of included MRPs. We estimated the proportion of studies published using prediction intervals (PI and a random effects meta-analysis. Pooled odds ratios (OR were used to express associations between study characteristics and journal publication. Seventeen MRPs (23 publications evaluated cohorts of studies approved by RECs; the proportion of published studies had a PI between 22% and 72% and the weighted pooled proportion when combining estimates would be 46.2% (95% CI 40.2%-52.4%, I2 = 94.4%. Twenty-two MRPs (22 publications evaluated cohorts of studies included in trial registries; the PI of the proportion published ranged from 13% to 90% and the weighted pooled proportion would be 54.2% (95% CI 42.0%-65.9%, I2 = 98.9%. REC-approved studies with statistically significant results (compared with those without statistically significant results were more likely to be published (pooled OR 2.8; 95% CI 2.2-3.5. Phase-III trials were also more likely to be published than phase II trials (pooled OR 2.0; 95% CI 1.6-2.5. The probability of publication within two

  2. A study of the current collecting sectors of a U-25B diagonal megnetohydrodynamic generator

    Energy Technology Data Exchange (ETDEWEB)

    Kirillov, V.V.; Panovka, M.Ya.; Semenov, V.D.; Sokolov, Yu.N.

    1983-01-01

    The results are cited of an experimental study and a calculated analysis of the operation of current collecting sectors of the U-25B magnetohydrodynamic (MHD) generator. The effect was studied of the parameters of the current, the coefficient of electrical loading, the disposition of the current collecting sectors (T) relative to the diagram of the magnetic field on the distribution of current along the length of the current collecting sectors. It is established that with optimal disposition of the current collecting sectors a uniform distribution of current is achieved. A simplified calculation model of the current collecting sector is developed. It is shown that the experimental and calculated relationships match well. The effect of the ballast resisters installed in the current collecting circuits on the distribution of current is examined. Their positive role in preventing current overloads on the frames and in supporting the uniform distribution of current is noted.

  3. A Study on the Current Oil and Gas Price Formula and Its Improvement

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chang Won; Lee, Young Koo [Korea Energy Economics Institute, Euiwang (Korea)

    2000-12-01

    The object of this study is to suggest some improvements on current price formulas on oil and gas which have been pivotal roles in the process of Korean economic growth. This study first examines basic frames and transition of oil and gas pricing in Korea and then finds some suggestions on them by scrutinizing their theoretical backgrounds. This study finds several problems on oil and gas pricing formulas. (a) In a model that is now studied to evaluate the current domestic oil price, the costs associated with oil security such as oil stockpile are fully penetrated into oil price without their fair evaluations. There is no evaluation principle on the costs occurred in oil supply security. (b) The Rate Of Equity(ROE), a crucial factor in town-gas pricing which is strictly controlled, is directly connected to the average interest rate on saving accounts of domestic commercial banks. Some arguments may have rise about inclusion a risk factor on ROE in order to compensate the uncertainty of town-gas business. (c) New demand for natural gas which is generated by new technologies or machinery and tools can help reduce the costs occurred from seasonal imbalance between power sector and gas sector. So it is also important to decide how to include the beneficiary of cost reduction in town-gas pricing. In order to evaluate the proper price levels, this study tests energy supply security by adopting methodologies such as Herfindahl Index and Portfolio Variance Risk. They can help develop the method to effectively improve the energy security and include the proper energy security costs into energy prices. This study also provides some suggestions for betterment of current ROE decision rule in town-gas business and for improvement of current town-gas policy that government subsidizes newly developed demand for strengthening price competitiveness in the early stage. (author). 145 refs., 16 figs., 49 tabs.

  4. The Study of the Geomagnetic Variation for Sq current System

    Science.gov (United States)

    Zhao, X.; Du, A.

    2012-04-01

    The solar quiet variation (Sq) with a period of 24 hrs is a typical one of the quiet variations. Sq is generally caused by atmospheric tide-dynamo in ionosphere and it is controlled by the electric field, electric conductivity in ionosphere and neutral wind in middle-high altitude atmosphere. In our work, the geomagnetic field data observed by 90 ground-based observatories is used to analyze the local time variation of Sq. Sq is derived from five quiet-day geomagnetic data in every month by the FFT method. According to the pattern of geomagnetic X component in Sq, there is a prenoon-postnoon (before noon and after noon) asymmetry. This asymmetry is obvious in spring, summer and winter. The X component at 12:00-13:00 LT is about 5 nT larger than it at 11:00-12:00 LT. The ratio between the X component of daily variable amplitude and Y component of daily variable amplitude in middle and low (high) latitude regions in summer is greater (smaller) than that in winter. Used the sphere harmonic analysis method, the Sq equivalent current system is obtained. From the pattern of Sq current system, the prenoon-postnoon asymmetry may be caused by the electric field in the high latitude region. This electric field has two effects: the one is that the electric field from high latitude maps to the low latitude region; the other is this electric field penetrate to the middle latitude region directly. The combined action of these two effects makes the prenoon-postnoon asymmetry of Sq. The asymmetry also has an obvious seasonal effect. It may relate to the polar Sq and DP2 in the high latitude region.

  5. The current status of orbital experiments for UHECR studies

    Science.gov (United States)

    Panasyuk, M. I.; Casolino, M.; Garipov, G. K.; Ebisuzaki, T.; Gorodetzky, P.; Khrenov, B. A.; Klimov, P. A.; Morozenko, V. S.; Sakaki, N.; Saprykin, O. A.; Sharakin, S. A.; Takizawa, Y.; Tkachev, L. G.; Yashin, I. V.; Zotov, M. Yu

    2015-08-01

    Two types of orbital detectors of extreme energy cosmic rays are being developed nowadays: (i) TUS and KLYPVE with reflecting optical systems (mirrors) and (ii) JEM-EUSO with high- transmittance Fresnel lenses. They will cover much larger areas than existing ground-based arrays and almost uniformly monitor the celestial sphere. The TUS detector is the pioneering mission developed in SINP MSU in cooperation with several Russian and foreign institutions. It has relatively small field of view (±4.5°), which corresponds to a ground area of 6.4 • 103 km2. The telescope consists of a Fresnel-type mirror-concentrator (∼ 2 m2) and a photo receiver (a matrix of 16 x 16 photomultiplier tubes). It is to be deployed on the Lomonosov satellite, and is currently at the final stage of preflight tests. Recently, SINP MSU began the KLYPVE project to be installed on board of the Russian segment of the ISS. The optical system of this detector contains a larger primary mirror (10 m2), which allows decreasing the energy threshold. The total effective field of view will be at least ±14° to exceed the annual exposure of the existing ground-based experiments. Several configurations of the detector are being currently considered. Finally, JEM-EUSO is a wide field of view (±30°) detector. The optics is composed of two curved double-sided Fresnel lenses with 2.65 m external diameter, a precision diffractive middle lens and a pupil. The ultraviolet photons are focused onto the focal surface, which consists of nearly 5000 multi-anode photomultipliers. It is developed by a large international collaboration. All three orbital detectors have multi-purpose character due to continuous monitoring of various atmospheric phenomena. The present status of development of the TUS and KLYPVE missions is reported, and a brief comparison of the projects with JEM-EUSO is given.

  6. Comparative study between an alternating current (AC) and a direct current (DC) electrification of an urban railway

    OpenAIRE

    Garriga Turu, Jordi

    2015-01-01

    This study will evaluate technically, energetic and economically the traction electrification network of the line Barcelona – Vallès operated by Ferrocarrils de la Generalitat de Catalunya (FGC) in the existing voltage system (1500 Vdc) and a new electrification under alternative current (25 kVac) will be proposed to be as well studied. The results obtained will be compared in order to obtain decision factors on which system best fits.

  7. Current sedation and monitoring practice for colonoscopy: an International Observational Study (EPAGE)

    DEFF Research Database (Denmark)

    Froehlich, F; Harris, JK; Wietlisbach, V;

    2006-01-01

    in endoscopy centers internationally. PATIENTS AND METHODS: This observational study included consecutive patients referred for colonoscopy at 21 centers in 11 countries. Endoscopists reported sedation and monitoring practice, using a standard questionnaire for each patient. RESULTS: 6004 patients were......BACKGROUND AND STUDY AIMS: Sedation and monitoring practice during colonoscopy varies between centers and over time. Knowledge of current practice is needed to ensure quality of care and help focus future research. The objective of this study was to examine sedation and monitoring practice...... included in this study, of whom 53 % received conscious/moderate sedation during colonoscopy, 30 % received deep sedation, and 17 % received no sedation. Sedation agents most commonly used were midazolam (47 %) and opioids (33 %). Pulse oximetry was done during colonoscopy in 77 % of patients, blood...

  8. Ecology of Urban Bees: A Review of Current Knowledge and Directions for Future Study

    Directory of Open Access Journals (Sweden)

    Gordon W. Frankie

    2009-01-01

    Full Text Available Urban bee ecology is an emerging field that holds promise for advancing knowledge of bee community dynamics and promoting bee conservation. Published studies of bee communities in urban and suburban habitats are fewer than those documenting bees in agricultural and wildland settings. As land lost to urbanization is predicted to increase in coming years the necessity of studying urban bee populations is growing. We reviewed 59 publications on urban bee ecology with the following goals, to assess current knowledge, to highlight areas in need of further research, and to suggest applications of study findings to bee conservation. Identified trends in urban areas included the following, negative correlation between bee species richness and urban development, increase in abundance of cavity-nesters in urban habitats, and scarcity of floral specialists. Future directions for studying urban bee ecology include incorporation of landscape-scale assessments, conducting manipulative experiments and actively designing urban bee habitats.

  9. Evaluation and study of advanced optical contamination, deposition, measurement, and removal techniques. [including computer programs and ultraviolet reflection analysis

    Science.gov (United States)

    Linford, R. M. F.; Allen, T. H.; Dillow, C. F.

    1975-01-01

    A program is described to design, fabricate and install an experimental work chamber assembly (WCA) to provide a wide range of experimental capability. The WCA incorporates several techniques for studying the kinetics of contaminant films and their effect on optical surfaces. It incorporates the capability for depositing both optical and contaminant films on temperature-controlled samples, and for in-situ measurements of the vacuum ultraviolet reflectance. Ellipsometer optics are mounted on the chamber for film thickness determinations, and other features include access ports for radiation sources and instrumentation. Several supporting studies were conducted to define specific chamber requirements, to determine the sensitivity of the measurement techniques to be incorporated in the chamber, and to establish procedures for handling samples prior to their installation in the chamber. A bibliography and literature survey of contamination-related articles is included.

  10. Music Therapy With Premature Infants and Their Caregivers in Colombia – A Mixed Methods Pilot Study Including a Randomized Trial

    OpenAIRE

    Mark Ettenberger; Helen Odell-Miller; Cátherine Rojas Cárdenas; Sergio Torres Serrano; Mike Parker; Sandra Milena Camargo Llanos

    2014-01-01

    This article reports the results of a three-arm mixed methods pilot study of music therapy with premature infants and their caregivers in a Neonatal Intensive Care Unit (NICU) in Bogotá, Colombia. The study included 19 medically stable babies born between the 30th and 37th week of gestation and their caregivers. Two intervention groups were compared with a control group. The objectives were to find out whether music therapy could help the neonates to stabilize their physiological states a...

  11. The current status of orbital experiments for UHECR studies

    CERN Document Server

    Panasyuk, M I; Garipov, G K; Ebisuzaki, T; Gorodetzky, P; Khrenov, B A; Klimov, P A; Morozenko, V S; Sakaki, N; Saprykin, O A; Sharakin, S A; Takizawa, Y; Tkachev, L G; Yashin, I V; Zotov, M Yu

    2015-01-01

    Two types of orbital detectors of extreme energy cosmic rays are being developed nowadays: (i) TUS and KLYPVE with reflecting optical systems (mirrors) and (ii) JEM-EUSO with high-transmittance Fresnel lenses. They will cover much larger areas than existing ground-based arrays and almost uniformly monitor the celestial sphere. The TUS detector is the pioneering mission developed in SINP MSU in cooperation with several Russian and foreign institutions. It has relatively small field of view (+/-4.5 deg), which corresponds to a ground area of 6.4x10^3 sq.km. The telescope consists of a Fresnel-type mirror-concentrator (~2 sq.m) and a photo receiver (a matrix of 16x16 photomultiplier tubes). It is to be deployed on the Lomonosov satellite, and is currently at the final stage of preflight tests. Recently, SINP MSU began the KLYPVE project to be installed on board of the Russian segment of the ISS. The optical system of this detector contains a larger primary mirror (10 sq.m), which allows decreasing the energy thr...

  12. Current studies on human papillomavirus in Saudi Arabia.

    Science.gov (United States)

    Alhamlan, Fatimah Saeed; Al-Qahtani, Ahmed A; Al-Ahdal, Mohammed N

    2015-07-04

    Human papillomavirus (HPV) infection is a significant etiological factor and an important prognosticator in cervical cancer. Indeed, researchers worldwide have confirmed these roles for high-risk HVPs in over 70% of cervical cancer cases. According to the World Health Organization, approximately 561,200 new cancer cases (5.2% of all new cancers) are attributed to HPV infection. Over 120 types of HPV are classified further as either low-risk HPV (LR-HPV) or high-risk HPV (HR-HPV) based on their oncological potential of transforming cells. The LR-HPV types cause benign hyperproliferative lesions (i.e. genital warts) while the HR-HPV types are strongly associated with premalignant and malignant cervical lesions. Data on the prevalence of HPV, survival of infected patients, and mortality rate are scarce in Saudi Arabia. The unsubstantiated assumption of a low prevalence of HPV in Saudi Arabia has contributed to limiting HPV research in this conservative country. Therefore, the goal of this review is to shed light on the current HPV research being conducted and the prevalence of HPV in Saudi Arabia.

  13. Retooling the Social Studies Classroom for the Current Generation

    Science.gov (United States)

    Wilson, Elizabeth K.; Wright, Vivian H.; Inman, Christopher T.; Matherson, Lisa H.

    2011-01-01

    Digital technologies have changed the way students read and communicate. Subsequently, teachers must use technology to engage their students in learning. This article illustrates the value of using Web 2.0 tools (blogs, wikis, and digital media-sharing) in the social studies classroom. Additionally, a social studies teacher shares insights into…

  14. A Review of Current Studies on Human Capital

    Institute of Scientific and Technical Information of China (English)

    黄思雅

    2012-01-01

      This paper introduces some previous studies on human capital, mainly regarding human capital’s properties and its relationship with corporate performance and capital structure. This study shows the importance of human capital and suggests that managers should pay more attention to employees.

  15. Review of current study methods for VRU safety

    DEFF Research Database (Denmark)

    Andersen, Camilla Sloth; Kamaluddin, Noor Azreena; Várhelyi, András

    written questionnaires (either online or paper-based), interviews may be performed (either face-to-face or via telephone) and people may be asked to report their accident via an app on their mobile device. The method for gaining self-reported information thus varies greatly – and so does the information...... that people are asked to give. In most studies, only the number of accidents in which the respondent was involved is relevant for the researcher. In other studies, respondents are asked about possible accident causation factors, and some studies deal with respondents’ recall of the accident details. In other...

  16. Current approaches of genome-wide association studies

    Institute of Scientific and Technical Information of China (English)

    Jianfeng Xu

    2008-01-01

    @@ With rapid advances in high-throughput genotyping technology and the great increase in information available on SNPs throughout the genuine, genuine-wide association(GWA) studies have now become feasible.

  17. Cost-of-Illness Studies: A Review of Current Methods

    OpenAIRE

    Ebere Akobundu; Jing Ju; Lisa Blatt; C Daniel Mullins

    2006-01-01

    The number of cost-of-illness (COI) studies has expanded considerably over time. One outcome of this growth is that the reported COI estimates are inconsistent across studies, thereby raising concerns over the validity of the estimates and methods. Several factors have been identified in the literature as reasons for the observed variation in COI estimates. To date, the variation in the methods used to calculate costs has not been examined in great detail even though the variations in methods...

  18. Patient experienced continuity of care in the psychiatric healthcare system-a study including immigrants, refugees and ethnic danes.

    Science.gov (United States)

    Jensen, Natasja Koitzsch; Johansen, Katrine Schepelern; Kastrup, Marianne; Krasnik, Allan; Norredam, Marie

    2014-09-17

    The purpose of this study was to investigate continuity of care in the psychiatric healthcare system from the perspective of patients, including vulnerable groups such as immigrants and refugees. The study is based on 19 narrative interviews conducted with 15 patients with diverse migration backgrounds (immigrants, descendents, refugees, and ethnic Danes). Patients were recruited from a community psychiatric centre situated in an area with a high proportion of immigrants and refugees. Data were analysed through the lens of a theoretical framework of continuity of care in psychiatry, developed in 2004 by Joyce et al., which encompasses four domains: accessibility, individualised care, relationship base and service delivery. Investigating continuity of care, we found issues of specific concern to immigrants and refugees, but also commonalities across the groups. For accessibility, areas pertinent to immigrants and refugees include lack of knowledge concerning mental illness and obligations towards children. In terms of individualised care, trauma, additional vulnerability, and taboo concerning mental illness were of specific concern. In the domain of service delivery, social services included assistance with immigration papers for immigrants and refugees. In the relationship base domain, no differences were identified. Implications for priority area: The treatment courses of patients in the psychiatric field are complex and diverse and the patient perspective of continuity of care provides important insight into the delivery of care. The study highlights the importance of person-centred care irrespective of migration background though it may be beneficial to have an awareness of areas that may be of more specific concern to immigrants and refugees. The study sheds light on concerns specific to immigrants and refugees in a framework of continuity of care, but also commonalities across the patient groups.

  19. Patient Experienced Continuity of Care in the Psychiatric Healthcare System—A Study Including Immigrants, Refugees and Ethnic Danes

    Directory of Open Access Journals (Sweden)

    Natasja Koitzsch Jensen

    2014-09-01

    Full Text Available Aim: The purpose of this study was to investigate continuity of care in the psychiatric healthcare system from the perspective of patients, including vulnerable groups such as immigrants and refugees. Method: The study is based on 19 narrative interviews conducted with 15 patients with diverse migration backgrounds (immigrants, descendents, refugees, and ethnic Danes. Patients were recruited from a community psychiatric centre situated in an area with a high proportion of immigrants and refugees. Data were analysed through the lens of a theoretical framework of continuity of care in psychiatry, developed in 2004 by Joyce et al., which encompasses four domains: accessibility, individualised care, relationship base and service delivery. Results: Investigating continuity of care, we found issues of specific concern to immigrants and refugees, but also commonalities across the groups. For accessibility, areas pertinent to immigrants and refugees include lack of knowledge concerning mental illness and obligations towards children. In terms of individualised care, trauma, additional vulnerability, and taboo concerning mental illness were of specific concern. In the domain of service delivery, social services included assistance with immigration papers for immigrants and refugees. In the relationship base domain, no differences were identified. Implications for priority area: The treatment courses of patients in the psychiatric field are complex and diverse and the patient perspective of continuity of care provides important insight into the delivery of care. The study highlights the importance of person-centred care irrespective of migration background though it may be beneficial to have an awareness of areas that may be of more specific concern to immigrants and refugees. Conclusions: The study sheds light on concerns specific to immigrants and refugees in a framework of continuity of care, but also commonalities across the patient groups.

  20. The Course of Schizophrenia: E. Kraepelin's View and Current Studies

    Directory of Open Access Journals (Sweden)

    Norbert Müller

    2014-10-01

    Full Text Available Kraepelin's concept of dementia praecox and Bleuler's concept of the group of schizophrenias differ mainly under the aspect of course of the disorder. Follow-up studies play an important role for research regarding course, outcome and prognosis of psychiatric disorders, especially in terms of validation of psychiatric diagnosis and other psychiatric concepts, such as the concept of schizophrenic negative symptoms. Long-term studies also have their place in the description and evaluation of first treatment procedures. This paper will describe some general aspects of the long-term course and outcome of schizophrenic psychoses. The problem of relapses and relapse prevention will then be discussed. Especially data from recent studies will be considered in this overview.

  1. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies.

    Science.gov (United States)

    Magnuson, B A; Burdock, G A; Doull, J; Kroes, R M; Marsh, G M; Pariza, M W; Spencer, P S; Waddell, W J; Walker, R; Williams, G M

    2007-01-01

    Aspartame is a methyl ester of a dipeptide used as a synthetic nonnutritive sweetener in over 90 countries worldwide in over 6000 products. The purpose of this investigation was to review the scientific literature on the absorption and metabolism, the current consumption levels worldwide, the toxicology, and recent epidemiological studies on aspartame. Current use levels of aspartame, even by high users in special subgroups, remains well below the U.S. Food and Drug Administration and European Food Safety Authority established acceptable daily intake levels of 50 and 40 mg/kg bw/day, respectively. Consumption of large doses of aspartame in a single bolus dose will have an effect on some biochemical parameters, including plasma amino acid levels and brain neurotransmitter levels. The rise in plasma levels of phenylalanine and aspartic acid following administration of aspartame at doses less than or equal to 50 mg/kg bw do not exceed those observed postprandially. Acute, subacute and chronic toxicity studies with aspartame, and its decomposition products, conducted in mice, rats, hamsters and dogs have consistently found no adverse effect of aspartame with doses up to at least 4000 mg/kg bw/day. Critical review of all carcinogenicity studies conducted on aspartame found no credible evidence that aspartame is carcinogenic. The data from the extensive investigations into the possibility of neurotoxic effects of aspartame, in general, do not support the hypothesis that aspartame in the human diet will affect nervous system function, learning or behavior. Epidemiological studies on aspartame include several case-control studies and one well-conducted prospective epidemiological study with a large cohort, in which the consumption of aspartame was measured. The studies provide no evidence to support an association between aspartame and cancer in any tissue. The weight of existing evidence is that aspartame is safe at current levels of consumption as a nonnutritive

  2. Current methodology and methods in psychophysiological studies of creative thinking.

    Science.gov (United States)

    Bechtereva, N P; Danko, S G; Medvedev, S V

    2007-05-01

    Important points on methodology and detailed description of methods used in polymodal psychophysiological studies of human verbal creative thinking are presented. The psychophysiological studies were conducted with healthy volunteers during implementations of specially developed and adapted psychological tests aimed to bring the subjects into states of verbal creative thinking. Four different task sets ("story composition", "associative chains", "original definitions", "proverb sense flipping") were developed and applied. Positron emission tomography of regional cerebral blood flow (rCBF) and state-related quantitative electroencephalography (power and coherence evaluated) were used. The effectiveness of the methods is illustrated with figures.

  3. Review of Current FFAG Lattice Studies in North America

    Energy Technology Data Exchange (ETDEWEB)

    Berg, J. Scott; Plamer, Robert; Ruggiero, Alessandro; Trbojevic, Dejan; Keil, Eberhard; Johnstone, Carol; Sessler, Andrew; Koscielniak, Shane Rupert; Craddock, Michael

    2004-04-01

    There has been a revival of interest in the use of fixed field alternating gradient accelerators (FFAGs) for many applications, including muon accelerators, high-intensity proton sources, and medical applications. The original FFAGs, and those recently built in Japan, have been based on a so-called scaling FFAG design, for which tunes are constant and the behavior in phase space is independent of energy with the exception of a scaling factor. Activity in the US and Canada has instead mostly focused on nonscaling designs, which, while having the large energy acceptance that characterizes an FFAG, do not obey the scaling relations of the scaling FFAG. Most of these designs have been based on magnets with a linear midplane field profile. A great deal of analysis, both theoretically and numerically, has occurred on these designs, and they are very well understood at this point. Some more recent work has occurred on designs with a nonlinear field profile. Since no non-scaling FFAG has ever been built, there is interest in building a small model which would accelerate electrons and demonstrate our understanding of non-scaling FFAG design.

  4. Dosimetric Study of Current Treatment Options for Radiotherapy in Retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Eldebawy, Eman [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Department of Radiation Oncology, Children' s Cancer Hospital, Cairo (Egypt); Parker, William, E-mail: william.parker@mcgill.ca [Department of Medical Physics, McGill University Health Centre, Montreal, Quebec (Canada); Abdel Rahman, Wamied [Department of Medical Physics, McGill University Health Centre, Montreal, Quebec (Canada); Freeman, Carolyn R. [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada)

    2012-03-01

    Purpose: To determine the best treatment technique for patients with retinoblastoma requiring radiotherapy to the whole eye. Methods and Materials: Treatment plans for 3 patients with retinoblastoma were developed using 10 radiotherapy techniques including electron beams, photon beam wedge pair (WP), photon beam three-dimensional conformal radiotherapy (3D-CRT), fixed gantry intensity-modulated radiotherapy (IMRT), photon volumetric arc therapy (VMAT), fractionated stereotactic radiotherapy, and helical tomotherapy (HT). Dose-volume analyses were carried out for each technique. Results: All techniques provided similar target coverage; conformity was highest for VMAT, nine-field (9F) IMRT, and HT (conformity index [CI] = 1.3) and lowest for the WP and two electron techniques (CI = 1.8). The electron techniques had the highest planning target volume dose gradient (131% of maximum dose received [D{sub max}]), and the CRT techniques had the lowest (103% D{sub max}) gradient. The volume receiving at least 20 Gy (V{sub 20Gy}) for the ipsilateral bony orbit was lowest for the VMAT and HT techniques (56%) and highest for the CRT techniques (90%). Generally, the electron beam techniques were superior in terms of brain sparing and delivered approximately one-third of the integral dose of the photon techniques. Conclusions: Inverse planned image-guided radiotherapy delivered using HT or VMAT gives better conformity index, improved orbital bone and brain sparing, and a lower integral dose than other techniques.

  5. Electrophysiological studies of malaria parasite-infected erythrocytes: Current status

    OpenAIRE

    Staines, Henry M.; Alkhalil, Abdulnaser; Allen, Richard J.; De Jonge, Hugo R.; Derbyshire, Elvira; Egée, Stéphane; Ginsburg, Hagai; Hill, David A.; Huber, Stephan M.; Kirk, Kiaran; Lang, Florian; Lisk, Godfrey; Oteng, Eugene; Pillai, Ajay D.; Rayavara, Kempaiah

    2007-01-01

    The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came...

  6. Electrophysiological studies of malaria parasite-infected erythrocytes: Current status

    Science.gov (United States)

    Staines, Henry M.; Alkhalil, Abdulnaser; Allen, Richard J.; De Jonge, Hugo R.; Derbyshire, Elvira; Egée, Stéphane; Ginsburg, Hagai; Hill, David A.; Huber, Stephan M.; Kirk, Kiaran; Lang, Florian; Lisk, Godfrey; Oteng, Eugene; Pillai, Ajay D.; Rayavara, Kempaiah; Rouhani, Sherin; Saliba, Kevin J.; Shen, Crystal; Solomon, Tsione; Thomas, Serge L. Y.; Verloo, Patrick; Desai, Sanjay A.

    2009-01-01

    The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding. PMID:17292372

  7. The end of universality: new collectivities in current literary studies

    Directory of Open Access Journals (Sweden)

    Ronald Greene

    2015-11-01

    Full Text Available The author investigates how the literary studies reacted to the conceptual crises of universalism, especially after WWII. In order to replace a concept that refers to the ability of a literary work to transcend time and space, literary studies should focus on different and specific collectivities that, situated in time and space, read and interpret literary works. The author makes use of the concept of the obverse, in which two poems, from different historical moments and intellectual traditions are compared based on a common social-historical problem they are trying to solve.    O autor investiga sobre como os estudos literários reagiram à crise do conceito de universalismo, sobretudo depois da II Guerra Mundial. Para substituir um conceito que se refere à capacidade de uma obra literária transcender tempo e espaço, os estudos literários deveriam indagar sobre as diferentes coletividades específicas, no tempo e no espaço, que leem e dão significado à obra literária. Para isso, o autor se utiliza do conceito de “obverso”, em que dois poemas, de épocas e tradições intelectuais diferentes, são comparados a partir de um problema sócio-histórico que tentam resolver.      This work is licensed under a Creative Commons Attribution 3.0 License.

  8. Bedrock geologic map of the Spring Valley, West Plains, and parts of the Piedmont and Poplar Bluff 30'x60' quadrangles, Missouri, including the upper Current River and Eleven Point River drainage basins

    Science.gov (United States)

    Weary, David J.; Harrison, Richard W.; Orndorff, Randall C.; Weems, Robert E.; Schindler, J. Stephen; Repetski, John E.; Pierce, Herbert A.

    2015-01-01

    This map covers the drainage basins of the upper Current River and the Eleven Point River in the Ozark Plateaus physiographic province of southeastern Missouri. The two surface drainage basins are contiguous in their headwaters regions, but are separated in their lower reaches by the lower Black River basin in the southeast corner of the map area. Numerous dye-trace studies demonstrate that in the contiguous headwaters areas, groundwater flows from the Eleven Point River basin into the Current River basin. Much of the groundwater discharge of the Eleven Point River basin emanates from Big Spring, located on the Current River. This geologic map and cross sections were produced to help fulfill a need to understand the geologic framework of the region in which this subsurface flow occurs.

  9. Current studies on physiological functions and biological production of lactosucrose.

    Science.gov (United States)

    Mu, Wanmeng; Chen, Qiuming; Wang, Xiao; Zhang, Tao; Jiang, Bo

    2013-08-01

    Lactosucrose (O-β-D-galactopyranosyl-(1,4)-O-α-D-glucopyranosyl-(1,2)-β-D-fructofuranoside) is a trisaccharide formed from lactose and sucrose by enzymatic transglycosylation. This rare trisaccharide is a kind of indigestible carbohydrate, has good prebiotic effect, and promotes intestinal mineral absorption. It has been used as a functional ingredient in a range of food products which are approved as foods for specified health uses in Japan. Using lactose and sucrose as substrates, lactosucrose can be produced through transfructosylation by β-fructofuranosidase from Arthrobacter sp. K-1 or a range of levansucrases, or through transgalactosylation by β-galactosidase from Bacillus circulans. This article presented a review of recent studies on the physiological functions of lactosucrose and the biological production from lactose and sucrose by different enzymes.

  10. Descriptive currents in philosophy of religion for Hebrew Bible studies

    Directory of Open Access Journals (Sweden)

    Jacobus W. Gericke

    2011-03-01

    Full Text Available This article argued that the utilisation of philosophy of religion in the study of the Hebrew Bible is possible if we look beyond the stereotype of erroneously equating the auxiliary field with natural theology, apologetics or atheological criticism. Fruitful possibilities for interdisciplinary research are available in the form of descriptive varieties of philosophy of religion primarily concerned with understanding and the clarification of meaning rather than with the stereotypical tasks of propositional justification or critical evaluation. Three examples are discussed in the article: analytic traditions (Wittgensteinianism and ordinarylanguage philosophy, phenomenological perspectives involving reduction (bracketing and comparative philosophy of religion that works in tandem with the history of religion and comparative religion.

  11. Music Therapy With Premature Infants and Their Caregivers in Colombia – A Mixed Methods Pilot Study Including a Randomized Trial

    Directory of Open Access Journals (Sweden)

    Mark Ettenberger

    2014-07-01

    Full Text Available This article reports the results of a three-arm mixed methods pilot study of music therapy with premature infants and their caregivers in a Neonatal Intensive Care Unit (NICU in Bogotá, Colombia. The study included 19 medically stable babies born between the 30th and 37th week of gestation and their caregivers. Two intervention groups were compared with a control group. The objectives were to find out whether music therapy could help the neonates to stabilize their physiological states and help mothers to reduce anxiety and strengthen the relationship with their baby. The data collection included the babies´ weight gain, heart rate, oxygen saturation, size, cephalic perimeter and length of hospitalization. Mothers filled out the State-Trait Anxiety Inventory (STAI-C and the Mother-to-Infant Bonding Scale (MIBS before the first and after the last intervention. Thematic analysis was used to analyze the qualitative data obtained through questionnaires. A trend towards an increased weight gain for both intervention groups and a shorter length of hospitalization for one of the intervention groups was noticed. Anxiety and bonding in mothers appears not to follow linear trends, as new challenges arise for parents at different stages during hospitalization. Mothers stated that music therapy was helpful for them, their baby and their relationship with the baby. Mothers across the groups think that music therapy should be a regular offer in the NICU and that music therapy helps to humanize the NICU environment.

  12. Current state of epidemiological studies in Belarus about Chernobyl sufferers

    Energy Technology Data Exchange (ETDEWEB)

    Matsko, V.P. [Institute of Radiobiology, Academy Sciences of Belarus, Minsk (Belarus)

    1998-03-01

    The present paper is an analysis of the results of epidemiological studies in Belarus about the after-effects of the accident at the Chernobyl atomic power station (ChAPS), based on published data at scientific institutes, organs and institutions of Ministry of Health. In the last years the affected population showed thereby more significant - as compared with republican indices - growth of incidence in the majority of diseases (first of all: digestion, urogenital, nervous, endocrine systems, diseases of ear, throat, nose both among adults and among children). Aggravation of health state continues in the participants of liquidation of the ChAPS accident consequences and the evacuees from the alienation zone which have obtained considerable radiation load to organism (rise of incidence of diseases of endocrine, cardiovascular, nervous system etc.). Considerable growth of thyroid cancer incidence is registered in Belarus children and adolescents, especially in the Gomel and Brest regions. This is conditioned by dose commitments on thyroid gland due to iodine radionuclides in first period after the accident, incorrect iodine prophylaxy, and goitre endemic. The rise of hereditary pathology is registered too. An expressed increase of oncological diseases is observed therewith mainly in the Gomel region, especially in the districts with high level of radiocontamination and, consequently, significant radiation load. First of all, this relates to the growth of incidence of cancer of lungs, mammary gland, bladder. The analysis of epidemiological studies performed in Belarus after the ChAPS catastrophe and comparison of them with data obtained in the pre-Chernobyl period testify to the aggravation of health state of Belarus population. The specialists unambiguously recognize the direct influence of radioactive pollution in the environment on rise of thyroid pathologies, hereditary and congenial diseases, and cancers of different localizations. There is no unique opinion

  13. Prolonged-release nicotinic acid for the management of dyslipidemia: an update including results from the NAUTILUS study

    Directory of Open Access Journals (Sweden)

    Anja Vogt

    2007-09-01

    Full Text Available Anja Vogt1, Ursula Kassner1, Ulrike Hostalek2, Elisabeth Steinhagen-Thiessen11Charite-Universitatsmedizin Berlin, Germany; 2Merck KGaA, Darmstadt, GermanyAbstract: Low HDL-cholesterol (<1.02 mmol/L [40 mg/dL] in men or <1.29 mmol/L [50 mg/dL] in women occurs in about one-third of European patients with dyslipidemia and is an independent cardiovascular risk factor. Simultaneous correction of low HDL-cholesterol and high totalcholesterol and LDL-cholesterol may provide reductions in cardiovascular morbidity and mortality beyond those possible with statins alone. Nicotinic acid (niacin in the US is the most effective means of increasing HDL-cholesterol available and has been shown to reduce cardiovascular event rates significantly. Niaspan® (prolonged-release nicotinic acid provides a convenient, once-daily means of administering nicotinic acid. Clinical studies with Niaspan® have demonstrated marked, long-term increases in HDL-cholesterol with additional useful benefits on triglycerides, LDLcholesterol, and lipid sub-profiles. The NAUTILUS study demonstrated the beneficial efficacy and tolerability profiles of Niaspan® in a usual-care setting. The most common side-effect of Niaspan® is flushing, which infrequently causes treatment discontinuation and which usually subsides over continued treatment. The ARBITER 2 and ARBITER 3 studies showed 1–2 years of treatment with Niaspan® plus a statin induced regression of atherosclerosis in patients with coronary artery disease. The effect of Niaspan®-statin treatment, relative to a statin alone, on clinical cardiovascular outcomes is currently under evaluation. Niaspan® represents a practical means of correcting low HDL-cholesterol, an independent risk factor for adverse cardiovascular outcomes.Keywords: prolonged-release nicotinic acid, Niaspan®, niacin, dyslipidemia, HDL-cholesterol cardiovascular risk

  14. Current trends in research and clinical issues in the study of personality and its disorders

    DEFF Research Database (Denmark)

    Simonsen, Erik; Sørensen, Per; Pedersen, Liselotte

    2014-01-01

    lecture (Simonsen), a young researchers' symposium (Hopwood, Sharp, and Kaess), and special lectures on the Danish philosopher Soeren Kierkegaard and the poet Hans Christian Andersen. In this article we will survey the presentations and highlight the important issues in order to underline the current......The International Society for the Study of Personality Disorders (ISSPD) celebrated its 25th anniversary in September 2013 in Copenhagen and commemorated the First International Congress at the same site. The overall theme of the congress was "Bridging Personality and Psychopathology: The Person...... Behind the Illness." More than 400 abstracts were submitted, and the program included 8 keynote presentations, 18 invited symposia, a debate on current controversial issues in the classification of personality disorders (Fossati, Tyrer, Livesley, and Krueger), an ISSPD award lecture (Silk), a jubilee...

  15. Accelerating Virtual High-Throughput Ligand Docking: current technology and case study on a petascale supercomputer.

    Science.gov (United States)

    Ellingson, Sally R; Dakshanamurthy, Sivanesan; Brown, Milton; Smith, Jeremy C; Baudry, Jerome

    2014-04-25

    In this paper we give the current state of high-throughput virtual screening. We describe a case study of using a task-parallel MPI (Message Passing Interface) version of Autodock4 [1], [2] to run a virtual high-throughput screen of one-million compounds on the Jaguar Cray XK6 Supercomputer at Oak Ridge National Laboratory. We include a description of scripts developed to increase the efficiency of the predocking file preparation and postdocking analysis. A detailed tutorial, scripts, and source code for this MPI version of Autodock4 are available online at http://www.bio.utk.edu/baudrylab/autodockmpi.htm.

  16. Implementing a benchmarking and feedback concept decreases postoperative pain after total knee arthroplasty: A prospective study including 256 patients

    Science.gov (United States)

    Benditz, A.; Drescher, J.; Greimel, F.; Zeman, F.; Grifka, J.; Meißner, W.; Völlner, F.

    2016-01-01

    Perioperative pain reduction, particularly during the first two days, is highly important for patients after total knee arthroplasty (TKA). Problems are not only caused by medical issues but by organization and hospital structure. The present study shows how the quality of pain management can be increased by implementing a standardized pain concept and simple, consistent benchmarking. All patients included into the study had undergone total knee arthroplasty. Outcome parameters were analyzed by means of a questionnaire on the first postoperative day. A multidisciplinary team implemented a regular procedure of data analyzes and external benchmarking by participating in a nationwide quality improvement project. At the beginning of the study, our hospital ranked 16th in terms of activity-related pain and 9th in patient satisfaction among 47 anonymized hospitals participating in the benchmarking project. At the end of the study, we had improved to 1st activity-related pain and to 2nd in patient satisfaction. Although benchmarking started and finished with the same standardized pain management concept, results were initially pure. Beside pharmacological treatment, interdisciplinary teamwork and benchmarking with direct feedback mechanisms are also very important for decreasing postoperative pain and for increasing patient satisfaction after TKA. PMID:27917911

  17. The Current Status of Usability Studies of Information Technologies in China: A Systematic Study

    OpenAIRE

    Lei, Jianbo; Xu, Lufei; Meng, Qun; Zhang, Jiajie; Gong, Yang

    2014-01-01

    Objectives. To systematically review and analyze the current status and characteristics of usability studies in China in the field of information technology in general and in the field of healthcare in particular. Methods. We performed a quantitative literature analysis in three major Chinese academic databases and one English language database using Chinese search terms equivalent to the concept of usability. Results. Six hundred forty-seven publications were selected for analysis. We found ...

  18. Reduced Dietary Sodium Intake Increases Heart Rate. A Meta-Analysis of 63 Randomized Controlled Trials Including 72 Study Populations.

    Science.gov (United States)

    Graudal, Niels A; Hubeck-Graudal, Thorbjørn; Jürgens, Gesche

    2016-01-01

    Reduced dietary sodium intake (sodium reduction) increases heart rate in some studies of animals and humans. As heart rate is independently associated with the development of heart failure and increased risk of premature death a potential increase in heart rate could be a harmful side-effect of sodium reduction. The purpose of the present meta-analysis was to investigate the effect of sodium reduction on heart rate. Relevant studies were retrieved from an updated pool of 176 randomized controlled trials (RCTs) published in the period 1973-2014. Sixty-three of the RCTs including 72 study populations reported data on heart rate. In a meta-analysis of these data sodium reduction increased heart rate with 1.65 beats per minute [95% CI: 1.19, 2.11], p sodium reduction increases heart rate by as much (2.4%) as it decreases blood pressure (2.5%). This side-effect, which may cause harmful health effects, contributes to the need for a revision of the present dietary guidelines.

  19. Modeling studies of the coastal/littoral current system off Southern Australia

    OpenAIRE

    Miller, Henry A.

    2006-01-01

    Both theoretical and numerical modeling studies of the current system off western and southern Australia are conducted to characterize the features of the current system, their temporal variability, and their impact on the sound speed structure. The theoretical study examines why boundary current separation occurs off Cape Leeuwin creating an area of enhanced eddy generation. It is shown that the beta effect, vortex stretching, and streamline curvature all act to decelerate the current a...

  20. Pyrometry temperature studies of shocked tin including investigations exploring surface defects, anvil diameter and the integration with emissivity diagnostics

    Science.gov (United States)

    Shenton-Taylor, Caroline; de'Ath, James; Ota, Thomas

    2009-06-01

    Accurate temperature measurement of shock-loaded systems continues to present experimental challenges. With short measurable time durations diagnostic methods are almost exclusively restricted to optical techniques. By preventing full sample pressure unloading, through the use of an anvil, partial release temperature measurements can be deduced from multiple wavelength optical pyrometry. This paper presents our recent studies of tin shocked to 28GPa including investigations exploring surface defects, anvil dimensions and the integration with emissivity diagnostics. The results indicate that a ring groove, 5mm across and with a nominal machined depth of 50 microns, acts to enhance the measured temperature by approximately 150K. Additionally on reducing the LiF anvil diameter from 20mm to 15mm, comparable partial release temperatures were observed. With the anticipated development of multiple anvil target designs, the smaller anvil diameter is desirable. British Crown Copyright 2009/MOD.

  1. ANFIS-based approach to studying subthreshold behavior including the traps effect for nanoscale thin-film DG MOSFETs

    Institute of Scientific and Technical Information of China (English)

    T.Bentrcia; F.Djeffal; E.Chebaaki

    2013-01-01

    A fuzzy framework based on an adaptive network fuzzy inference system (ANFIS) is proposed to evaluate the relative degradation of the basic subthreshold parameters due to hot-carrier effects for nanoscale thin-film double-gate (DG) MOSFETs.The effect of the channel length and thickness on the resulting degradation is addressed,and 2-D numerical simulations are used for the elaboration of the training database.Several membership function shapes are developed,and the best one in terms of accuracy is selected.The predicted results agree well with the 2-D numerical simulations and can be efficiently used to investigate the impact of the interface fixed charges and quantum confinement on nanoscale DG MOSFET subthreshold behavior.Therefore,the proposed ANFIS-based approach offers a simple and accurate technique to study nanoscale devices,including the hot-carrier and quantum effects.

  2. Carbon Dioxide Sequestration by Direct Mineral Carbonation: Results from Recent Studies and Current Status

    Energy Technology Data Exchange (ETDEWEB)

    O' Connor, William K.; Dahlin, David C.; Nilsen, David N.; Rush, G.E.; Walters, Richard P.; Turner, Paul C.

    2001-01-01

    Direct mineral carbonation has been investigated as a process to convert gaseous CO2 into a geologically stable, solid final form. The process utilizes a solution of sodium bicarbonate (NaHCO3), sodium chloride (NaCl), and water, mixed with a mineral reactant, such as olivine (Mg2SiO4) or serpentine [Mg3Si2O5(OH)4]. Carbon dioxide is dissolved into this slurry, by diffusion through the surface and gas dispersion within the aqueous phase. The process includes dissolution of the mineral and precipitation of magnesium carbonate (MgCO3) in a single unit operation. Optimum results have been achieved using heat pretreated serpentine feed material, with a surface area of roughly 19 m2 per gram, and high partial pressure of CO2 (PCO2). Specific conditions include: 155?C; PCO2=185 atm; 15% solids. Under these conditions, 78% stoichiometric conversion of the silicate to the carbonate was achieved in 30 minutes. Studies suggest that the mineral dissolution rate is primarily surface controlled, while the carbonate precipitation rate is primarily dependent on the bicarbonate concentration of the slurry. Current studies include further examination of the reaction pathways, and an evaluation of the resource potential for the magnesium silicate reactant, particularly olivine. Additional studies include the examination of various pretreatment options, the development of a continuous flow reactor, and an evaluation of the economic feasibility of the process.

  3. Dosage considerations for transcranial direct current stimulation in children: a computational modeling study.

    Directory of Open Access Journals (Sweden)

    Sudha Kilaru Kessler

    Full Text Available Transcranial direct current stimulation (tDCS is being widely investigated in adults as a therapeutic modality for brain disorders involving abnormal cortical excitability or disordered network activity. Interest is also growing in studying tDCS in children. Limited empirical studies in children suggest that tDCS is well tolerated and may have a similar safety profile as in adults. However, in electrotherapy as in pharmacotherapy, dose selection in children requires special attention, and simple extrapolation from adult studies may be inadequate. Critical aspects of dose adjustment include 1 differences in neurophysiology and disease, and 2 variation in brain electric fields for a specified dose due to gross anatomical differences between children and adults. In this study, we used high-resolution MRI derived finite element modeling simulations of two healthy children, ages 8 years and 12 years, and three healthy adults with varying head size to compare differences in electric field intensity and distribution. Multiple conventional and high-definition tDCS montages were tested. Our results suggest that on average, children will be exposed to higher peak electrical fields for a given applied current intensity than adults, but there is likely to be overlap between adults with smaller head size and children. In addition, exposure is montage specific. Variations in peak electrical fields were seen between the two pediatric models, despite comparable head size, suggesting that the relationship between neuroanatomic factors and bioavailable current dose is not trivial. In conclusion, caution is advised in using higher tDCS doses in children until 1 further modeling studies in a larger group shed light on the range of exposure possible by applied dose and age and 2 further studies correlate bioavailable dose estimates from modeling studies with empirically tested physiologic effects, such as modulation of motor evoked potentials after stimulation.

  4. Identification of lifestyle patterns, including sleep deprivation, associated with insulin resistance in children: the Healthy Growth Study.

    Science.gov (United States)

    Androutsos, O; Moschonis, G; Mavrogianni, C; Roma-Giannikou, E; Chrousos, G P; Kanaka-Gantenbein, C; Manios, Y

    2014-03-01

    Although diet, physical activity (PA), sedentary behavior and sleep deprivation are factors that have been individually associated with insulin resistance (IR) in childhood, the combined effect of these lifestyle behaviors has not been examined yet. The current study aimed to examine the association of lifestyle patterns with IR, combining all these indices, in children. Socio-economic, demographic, anthropometric (body weight, height and waist circumference), biochemical (plasma glucose and serum insulin), clinical (pubertal stage) and lifestyle (dietary intake, PA level and sleeping habits) data were collected from a representative sample of 2026 children (50.1% girls) aged 9-13 years in Greece. Homeostasis model assessment (HOMA-IR) was calculated, and principal component analysis was used to identify lifestyle patterns, combining all these lifestyle indices. In multivariable regression analyses, the lifestyle pattern characterized by more screen time, shorter sleep duration and higher consumption of sugared beverages was positively associated with HOMA-IR (β=0.043; P=0.040), whereas the pattern characterized by more time spent on moderate-to-vigorous PA (MVPA) and more frequent eating occasions was inversely associated with HOMA-IR (β=-0.061; P=0.003). In logistic regression analyses, children with 72.2 min/day of MVPA and 5.05 eating occasions/day and children with 141.8 min/day of MVPA and 5.22 eating occasions/day were less likely of being insulin resistant based on HOMA-IR, compared with children with 20.0 min/day of MVPA and 4.09 eating occasions/day. A lifestyle pattern of >72 min of MVPA and 5 eating occasions/day was associated with reduced likelihood of IR in children.

  5. Numerical Study Of The Heat Transfer Phenomenon Of A Rectangular Plate Including Void, Notch Using Finite Difference Technique

    Science.gov (United States)

    Deb Nath, S. K.; Peyada, N. K.

    2015-12-01

    In the present study, we have developed a code using Matlab software for solving a rectangular aluminum plate having void, notch, at different boundary conditions discretizing a two dimensional (2D) heat conduction equation by the finite difference technique. We have solved a 2D mixed boundary heat conduction problem analytically using Fourier integrals (Deb Nath et al., 2006; 2007; 2007; Deb Nath and Ahmed, 2008; Deb Nath, 2008; Deb Nath and Afsar, 2009; Deb Nath and Ahmed, 2009; 2009; Deb Nath et al., 2010; Deb Nath, 2013) and the same problem is also solved using the present code developed by the finite difference technique (Ahmed et al., 2005; Deb Nath, 2002; Deb Nath et al., 2008; Ahmed and Deb Nath, 2009; Deb Nath et al., 2011; Mohiuddin et al., 2012). To verify the soundness of the present heat conduction code results using the finite difference method, the distribution of temperature at some sections of a 2D heated plate obtained by the analytical method is compared with those of the plate obtained by the present finite difference method. Interpolation technique is used as an example when the boundary of the plate does not pass through the discretized grid points of the plate. Sometimes hot and cold fluids are passed through rectangular channels in industries and many types of technical equipment. The distribution of temperature of plates including notches, slots with different temperature boundary conditions are studied. Transient heat transfer in several pure metallic plates is also studied to find out the required time to reach equilibrium temperature. So, this study will help find design parameters of such structures.

  6. Numerical Study Of The Heat Transfer Phenomenon Of A Rectangular Plate Including Void, Notch Using Finite Difference Technique

    Directory of Open Access Journals (Sweden)

    Deb Nath S.K.

    2015-12-01

    Full Text Available In the present study, we have developed a code using Matlab software for solving a rectangular aluminum plate having void, notch, at different boundary conditions discretizing a two dimensional (2D heat conduction equation by the finite difference technique. We have solved a 2D mixed boundary heat conduction problem analytically using Fourier integrals (Deb Nath et al., 2006; 2007; 2007; Deb Nath and Ahmed, 2008; Deb Nath, 2008; Deb Nath and Afsar, 2009; Deb Nath and Ahmed, 2009; 2009; Deb Nath et al., 2010; Deb Nath, 2013 and the same problem is also solved using the present code developed by the finite difference technique (Ahmed et al., 2005; Deb Nath, 2002; Deb Nath et al., 2008; Ahmed and Deb Nath, 2009; Deb Nath et al., 2011; Mohiuddin et al., 2012. To verify the soundness of the present heat conduction code results using the finite difference method, the distribution of temperature at some sections of a 2D heated plate obtained by the analytical method is compared with those of the plate obtained by the present finite difference method. Interpolation technique is used as an example when the boundary of the plate does not pass through the discretized grid points of the plate. Sometimes hot and cold fluids are passed through rectangular channels in industries and many types of technical equipment. The distribution of temperature of plates including notches, slots with different temperature boundary conditions are studied. Transient heat transfer in several pure metallic plates is also studied to find out the required time to reach equilibrium temperature. So, this study will help find design parameters of such structures.

  7. Surface photochemistry: Diffuse reflectance studies of thioketones included into p-tert-butylcalix[6 and 8]arenes

    Science.gov (United States)

    Vieira Ferreira, L. F.; Ferreira Machado, I.; Oliveira, A. S.; Da Silva, J. P.; Krawczyk, A.; Sikorski, M.

    2007-02-01

    This paper presents time resolved laser induced luminescence (LIL) and diffuse reflectance laser flash-photolysis (DRLFP) studies of solid powdered samples of xanthione (XT) and 4H-1-benzopyran-4-thione (BPT). These thioketones form inclusion complexes with p-tert-butylcalix[6]arene (CLX[6]) and p-tert-butylcalix[8]arene (CLX[8]). Room temperature air equilibrated LIL studies for XT/CLX[8] inclusion complex have shown the existence of both fluorescence and delayed fluorescence emission (S 2 → S 0 emissions in the nanosecond and microsecond time ranges, respectively) peaking at ca. 460 nm while phosphorescence peaks at about 670 nm with a half life of about 4 μs. For the BPT/CLX[8] inclusion complex, the emissions now peak at ca. 450 and 630 nm, respectively. When these two thioketones are included into the CLX[6] nanocavities similar luminescence spectra were detected. The phosphorescence spectra in all cases present a clear vibrational structure characteristic of non-polar environments, in accordance with the non-polar character of the calixarene's cavities. Diffuse reflectance transient absorption spectra revealed in all cases the presence of the triplet state of the thioketones and also of longer lived species. The use of chromatographic methods (GC-MS) allowed us to identify the formation of xanthone, chromone and hydroxy-thioketones following laser irradiation at 355 or 337 nm.

  8. Laboratory Studies of the Reactive Chemistry and Changing CCN Properties of Secondary Organic Aerosol, Including Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Scot Martin

    2013-01-31

    The chemical evolution of secondary-organic-aerosol (SOA) particles and how this evolution alters their cloud-nucleating properties were studied. Simplified forms of full Koehler theory were targeted, specifically forms that contain only those aspects essential to describing the laboratory observations, because of the requirement to minimize computational burden for use in integrated climate and chemistry models. The associated data analysis and interpretation have therefore focused on model development in the framework of modified kappa-Koehler theory. Kappa is a single parameter describing effective hygroscopicity, grouping together several separate physicochemical parameters (e.g., molar volume, surface tension, and van't Hoff factor) that otherwise must be tracked and evaluated in an iterative full-Koehler equation in a large-scale model. A major finding of the project was that secondary organic materials produced by the oxidation of a range of biogenic volatile organic compounds for diverse conditions have kappa values bracketed in the range of 0.10 +/- 0.05. In these same experiments, somewhat incongruently there was significant chemical variation in the secondary organic material, especially oxidation state, as was indicated by changes in the particle mass spectra. Taken together, these findings then support the use of kappa as a simplified yet accurate general parameter to represent the CCN activation of secondary organic material in large-scale atmospheric and climate models, thereby greatly reducing the computational burden while simultaneously including the most recent mechanistic findings of laboratory studies.

  9. Pregnancy Outcomes in Association with STDs including genital HSV-2 shedding in a South African Cohort Study.

    Science.gov (United States)

    Moodley, Dhayendre; Sartorius, Benn; Madurai, Savithree; Chetty, Vani; Maman, Suzanne

    2017-04-10

    Genital herpes simplex virus-2 (HSV-2) shedding in pregnant women in association with neonatal herpes infection has been widely studied but there is limited evidence of its association with pregnancy outcomes. In this retrospective observational study, we included a subgroup of pregnant women who were enrolled in a randomized control behavioural intervention study that was conducted in South Africa in 2008-2010. In pregnancy, women had a HIV rapid test done and a genital swab taken to test for curable STIs and HSV-2 DNA. Subsequent visits were scheduled for 6, 10, 14 weeks and 9 months post-delivery. Pregnancy outcomes were documented at the 6-week or 10-week postpartum visit. Women were treated syndromically for curable STIs. Among 615 women included in this data analysis, 36.6% (n=225) tested HIV positive and 8.3% (n=51) tested positive for genital HSV-2 shedding during pregnancy. Women <24 years and HIV-1 seropositive women were 1.5 and 2.5 times more likely to test positive for HSV-2 genital shedding respectively. STI treatment records were available for 158/205 (77.1%) women; all 87 women with symptomatic STIs were treated the same day, and 50/71 (70.4%) asymptomatic women received treatment at the subsequent visit. Remaining 21 (29.6%) asymptomatic women did not receive treatment because they failed to return for antenatal follow-up. In a multivariable regression analysis, genital HSV-2 shedding, HIV-1, Neisseria gonorrhoea, Chlamydia trachomatis and Trichomanas vaginalis were not associated with preterm deliveries, still births and low birth weight. However with stratification by treatment for a STI, asymptomatic women who were not treated were 3.3 times more likely to deliver prematurely (33.3%; n=6/18) when compared to women who were treated during pregnancy (13.2%; n=15/114) (p=0.042). Genital HSV-2 shedding in pregnancy does not appear to alter pregnancy outcomes. Untreated curable STIs (T.vaginalis, C.trachomatis, N.gonorrhoea) were more likely

  10. Major congenital malformations and residential proximity to a regional industrial park including a national toxic waste site: An ecological study

    Directory of Open Access Journals (Sweden)

    Polyakov Marina

    2006-03-01

    Full Text Available Abstract Background Public concern about exposure to emissions from the regional industrial park (IP, including 17 chemical plants and the national industrial toxic waste site, initiated this study of the possible association between major congenital malformations (MCM and residence near the IP in Israel's Southern District. Methods The study was conducted during the period 1995–2000 and included 63,850 deliveries. Data on deliveries and MCM detected at births were obtained from the regional medical center, and stratified by ethnicity and type of locality. As exposure indicator we used distance categories (proximal and distant and predominant wind direction from the IP. Distance stratification was based on the geographical distribution of the localities and complaints about the odor related to IP emissions. Based on these complaints, localities up to 20 km from the IP were considered proximal to the IP. Results Average rates of MCM were 5.0% and 4.1% for Bedouin and Jewish newborns, respectively. The rate of MCM for Bedouin from proximal localities was significantly greater compared with distant localities (5.6% vs. 4.8%; RR = 1.17 with 95% CI: 1.04–1.29. In the proximal Bedouin permanent localities, the MCM rate reached 8.2 %, which was significantly higher than in distant areas (RR = 1.63, 95% CI: 1.39–1.80. Significant risk increase of central nervous system MCM was found in these localities, compared to distant ones (RR = 2.27, 95% CI: 1.44–3.60. Among newborns from the traditional tribal settlements, proximity to the IP was associated with increased rates of the following MCM: 1 all combined, 2 those associated with chromosomal abnormalities, and 3 those defined as "others unclassified MCM." Comparison of autosomal recessive disease rates by proximity to the IP in Bedouin newborns indicates that the observed increased risk of MCM is not explained by consanguineous marriages. The rates of MCM in the Jewish population were similar

  11. [How do authors of systematic reviews restrict their literature searches when only studies from Germany should be included?

    Science.gov (United States)

    Pieper, Dawid; Mathes, Tim; Palm, Rebecca; Hoffmann, Falk

    2016-11-01

    The use of search filters (e. g. for study types) facilitates the process of literature searching. Regional limits might be helpful depending on the research question. Regional search filters are already available for some regions, but not for Germany. Our aim is to give an overview of applied search strategies in systematic reviews (SRs) focusing on Germany. We searched Medline (via Pubmed) applying a focused search strategy to identify SRs focusing on Germany in January 2016. Study selection and data extraction were performed by two reviewers independently. The search strategies with a focus on Germany were analyzed in terms of reasonableness and completeness relying on the Peer Review of Electronic Search Strategies (PRESS) criteria. A narrative evidence synthesis was performed. In total, 36 SRs (13 written in English) were included. 78% were published in 2012 or later. The majority (89%) of SRs utilized at least two different sources for their search with databases and checking references being the most common. 17 SRs did not use any truncations, ten SRs did not restrict their search to Germany, six SRs reported to have searched for German OR Germany. Only ten articles searched for the term Germany (occasionally jointly with the term Deutschland) without any use of an adjective such as German. There is a high interest in regionally focused SRs. The identified search strategies revealed a need for improvement. It would be helpful to develop a regional search filter for Germany that is able to identify studies performed in Germany. Copyright © 2016. Published by Elsevier GmbH.

  12. Current status and prospects for the study of Nicotiana genomics, genetics, and nicotine biosynthesis genes.

    Science.gov (United States)

    Wang, Xuewen; Bennetzen, Jeffrey L

    2015-02-01

    Nicotiana, a member of the Solanaceae family, is one of the most important research model plants, and of high agricultural and economic value worldwide. To better understand the substantial and rapid research progress with Nicotiana in recent years, its genomics, genetics, and nicotine gene studies are summarized, with useful web links. Several important genetic maps, including a high-density map of N. tabacum consisting of ~2,000 markers published in 2012, provide tools for genetics research. Four whole genome sequences are from allotetraploid species, including N. benthamiana in 2012, and three N. tabacum cultivars (TN90, K326, and BX) in 2014. Three whole genome sequences are from diploids, including progenitors N. sylvestris and N. tomentosiformis in 2013 and N. otophora in 2014. These and additional studies provide numerous insights into genome evolution after polyploidization, including changes in gene composition and transcriptome expression in N. tabacum. The major genes involved in the nicotine biosynthetic pathway have been identified and the genetic basis of the differences in nicotine levels among Nicotiana species has been revealed. In addition, other progress on chloroplast, mitochondrial, and NCBI-registered projects on Nicotiana are discussed. The challenges and prospects for genomic, genetic and application research are addressed. Hence, this review provides important resources and guidance for current and future research and application in Nicotiana.

  13. Equity perceptions and marital satisfaction in former and current marriage : A study among the remarried

    NARCIS (Netherlands)

    Buunk, BP; Mutsaers, W

    1999-01-01

    A study among 290 remarried individuals examined equity perceptions in the former and the current marriage. The results showed that equity in the former and the current marriage were not related to each other. In general, respondents perceived much more inequity in the former than in the current mar

  14. Dietary adherence and acceptability of five different diets, including vegan and vegetarian diets, for weight loss: The New DIETs study.

    Science.gov (United States)

    Moore, Wendy J; McGrievy, Michael E; Turner-McGrievy, Gabrielle M

    2015-12-01

    The goal of the present study was to examine dietary adherence and acceptability among participants from the New DIETs study who were randomized to one of four plant-based diets (vegan, vegetarian, pesco-vegetarian, semi-vegetarian) or an omnivore diet. Primary outcomes at two- and six months included dietary adherence (24-hour dietary recalls), weight loss and changes in animal product intake (mg cholesterol) by adherence status, Three-Factor Eating Questionnaire (TFEQ), Power of Food Scale (PFS), dietary acceptability (Food Acceptability Questionnaire), and impact of diet preference on adherence. No differences were found in dietary adherence or changes in FAQ, TFEQ, or PFS among the groups. At six months, non-adherent vegan and vegetarian participants (n=16) had a significantly greater decrease in cholesterol intake (-190.2 ± 199.2 mg) than non-adherent pesco-vegetarian/semi-vegetarian (n=15, -2.3 ± 200.3 mg, P=0.02) or omnivore participants (n=7, 17.0 ± 36.0, P=0.04). Non-adherent vegan/vegetarian participants lost significantly more weight at six months (-6.0 ± 6.7%) than non-adherent omnivore participants (-0.4 ± 0.6%, P=0.04). Dietary preference had no impact on adherence at six months. Due to equal rates of adherence and acceptability among the diet groups, instructing participants to follow vegan or vegetarian diets may have a greater impact on weight loss and animal product intake than providing instruction in more moderate approaches even among non-adherent participants.

  15. Microdeletions Including FMR1 in Three Female Patients with Intellectual Disability – Further Delineation of the Phenotype and Expression Studies

    Science.gov (United States)

    Zink, A.M.; Wohlleber, E.; Engels, H.; Rødningen, O.K.; Ravn, K.; Heilmann, S.; Rehnitz, J.; Katzorke, N.; Kraus, C.; Blichfeldt, S.; Hoffmann, P.; Reutter, H.; Brockschmidt, F.F.; Kreiß-Nachtsheim, M.; Vogt, P.H.; Prescott, T.E.; Tümer, Z.; Lee, J.A.

    2014-01-01

    Fragile X syndrome (FXS) is one of the most common causes of intellectual disability/developmental delay (ID/DD), especially in males. It is caused most often by CGG trinucleotide repeat expansions, and less frequently by point mutations and partial or full deletions of the FMR1 gene. The wide clinical spectrum of affected females partly depends on their X-inactivation status. Only few female ID/DD patients with microdeletions including FMR1 have been reported. We describe 3 female patients with 3.5-, 4.2- and 9.2-Mb de novo microdeletions in Xq27.3-q28 containing FMR1. X-inactivation was random in all patients, yet they presented with ID/DD as well as speech delay, macrocephaly and other features attributable to FXS. No signs of autism were present. Here, we further delineate the clinical spectrum of female patients with microdeletions. FMR1 expression studies gave no evidence for an absolute threshold below which signs of FXS present. Since FMR1 expression is known to be highly variable between unrelated females, and since FMR1 mRNA levels have been suggested to be more similar among family members, we further explored the possibility of an intrafamilial effect. Interestingly, FMR1 mRNA levels in all 3 patients were significantly lower than in their respective mothers, which was shown to be specific for patients with microdeletions containing FMR1. PMID:24715853

  16. Microdeletions including FMR1 in three female patients with intellectual disability - further delineation of the phenotype and expression studies

    DEFF Research Database (Denmark)

    Zink, A M; Wohlleber, E; Engels, H;

    2014-01-01

    Fragile X syndrome (FXS) is one of the most common causes of intellectual disability/developmental delay (ID/DD), especially in males. It is caused most often by CGG trinucleotide repeat expansions, and less frequently by point mutations and partial or full deletions of the FMR1 gene. The wide...... clinical spectrum of affected females partly depends on their X-inactivation status. Only few female ID/DD patients with microdeletions including FMR1 have been reported. We describe 3 female patients with 3.5-, 4.2- and 9.2-Mb de novo microdeletions in Xq27.3-q28 containing FMR1. X-inactivation was random...... in all patients, yet they presented with ID/DD as well as speech delay, macrocephaly and other features attributable to FXS. No signs of autism were present. Here, we further delineate the clinical spectrum of female patients with microdeletions. FMR1 expression studies gave no evidence for an absolute...

  17. NOAA/EcoFOCI Chukchi Sea ADCP Mooring time-series data, stations C1, C2, and C3, 2010-08-29 to 2012-08-22, including zonal (U) and meridional (V) current measurements. (NCEI Accession 0149848)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These Acoustic Doppler Current Profiler (ADCP) time-series data sets, consist of zonal current (U) and meridional current (V) measurements from moored instruments at...

  18. Numerical study on tidal currents and seawater exchange in the Benoa Bay, Bali, Indonesia

    Institute of Scientific and Technical Information of China (English)

    HENDRAWAN I. Gede; ASAI Koji

    2014-01-01

    A three-dimensional (3-D) finite volume coastal ocean model (FVCOM) was used for the study of water cir-culation and seawater exchange in the Benoa Bay, Bali Island. The M2 tidal component was forced in open boundary and discharge from six rivers was included in the numerical calculation. The M2 tidal elevation produced by the FVCOM has a good agreement with the observation data. The M2 tidal current is also suc-cessfully calculated under the ebb tide and flood tide conditions. The non-linear M2 tidal residual current was produced by the coastline geometry, especially surrounding the narrow strait between the Serangan Is-land and the Benoa Peninsula. The tidal residual current also generated two small eddies within the bay and one small eddy in the bay mouth. The salinity distribution influenced by river discharge could be success-fully calculated, where the numerical calculation and the observation results have a good correlation (r2) of 0.75. Finally in order to examine the seawater exchange in the Benoa Bay, the Lagrangian particle tracking method and calculation of residence time are applied. The mechanism of particle transport to the flushing of seawater is depicted clearly by both methods.

  19. Relationship between Urinary N-Desmethyl-Acetamiprid and Typical Symptoms including Neurological Findings: A Prevalence Case-Control Study.

    Science.gov (United States)

    Marfo, Jemima Tiwaa; Fujioka, Kazutoshi; Ikenaka, Yoshinori; Nakayama, Shouta M M; Mizukawa, Hazuki; Aoyama, Yoshiko; Ishizuka, Mayumi; Taira, Kumiko

    2015-01-01

    Neonicotinoid insecticides are nicotinic acetylcholine receptor agonists used worldwide. Their environmental health effects including neurotoxicity are of concern. We previously determined a metabolite of acetamiprid, N-desmethyl-acetamiprid in the urine of a patient, who exhibited some typical symptoms including neurological findings. We sought to investigate the association between urinary N-desmethyl-acetamiprid and the symptoms by a prevalence case-control study. Spot urine samples were collected from 35 symptomatic patients of unknown origin and 50 non-symptomatic volunteers (non-symptomatic group, NSG, 4-87 year-old). Patients with recent memory loss, finger tremor, and more than five of six symptoms (headache, general fatigue, palpitation/chest pain, abdominal pain, muscle pain/weakness/spasm, and cough) were in the typical symptomatic group (TSG, n = 19, 5-69 year-old); the rest were in the atypical symptomatic group (ASG, n = 16, 5-78 year-old). N-desmethyl-acetamiprid and six neonicotinoids in the urine were quantified by liquid chromatography-tandem mass spectrometry. The detection of N-desmethyl-acetamiprid was the most frequent and highest in TSG (47.4%, 6.0 ppb (frequency, maximum)), followed by in ASG (12.5%, 4.4 ppb) and in NSG (6.0%, 2.2 ppb), however acetamiprid was not detected. Thiamethoxam was detected in TSG (31.6%, 1.4 ppb), in ASG (6.3%, 1.9 ppb), but not in NSG. Nitenpyram was detected in TSG (10.5%, 1.2 ppb), in ASG (6.3%, not quantified) and in NSG (2.0%, not quantified). Clothianidin was only detected in ASG (6.3%, not quantified), and in NSG (2.0%, 1.6 ppb). Thiacloprid was detected in ASG (6.3%, 0.1 ppb). The cases in TSG with detection of N-desmethyl-acetamiprid and thiamethoxam were aged 5 to 62 years and 13 to 62 years, respectively. Detection of N-desmethyl-acetamiprid was associated with increased prevalence of the symptoms (odds ratio: 14, 95% confidence interval: 3.5-57). Urinary N-desmethyl-acetamiprid can be used as a

  20. Relationship between Urinary N-Desmethyl-Acetamiprid and Typical Symptoms including Neurological Findings: A Prevalence Case-Control Study.

    Directory of Open Access Journals (Sweden)

    Jemima Tiwaa Marfo

    Full Text Available Neonicotinoid insecticides are nicotinic acetylcholine receptor agonists used worldwide. Their environmental health effects including neurotoxicity are of concern. We previously determined a metabolite of acetamiprid, N-desmethyl-acetamiprid in the urine of a patient, who exhibited some typical symptoms including neurological findings. We sought to investigate the association between urinary N-desmethyl-acetamiprid and the symptoms by a prevalence case-control study. Spot urine samples were collected from 35 symptomatic patients of unknown origin and 50 non-symptomatic volunteers (non-symptomatic group, NSG, 4-87 year-old. Patients with recent memory loss, finger tremor, and more than five of six symptoms (headache, general fatigue, palpitation/chest pain, abdominal pain, muscle pain/weakness/spasm, and cough were in the typical symptomatic group (TSG, n = 19, 5-69 year-old; the rest were in the atypical symptomatic group (ASG, n = 16, 5-78 year-old. N-desmethyl-acetamiprid and six neonicotinoids in the urine were quantified by liquid chromatography-tandem mass spectrometry. The detection of N-desmethyl-acetamiprid was the most frequent and highest in TSG (47.4%, 6.0 ppb (frequency, maximum, followed by in ASG (12.5%, 4.4 ppb and in NSG (6.0%, 2.2 ppb, however acetamiprid was not detected. Thiamethoxam was detected in TSG (31.6%, 1.4 ppb, in ASG (6.3%, 1.9 ppb, but not in NSG. Nitenpyram was detected in TSG (10.5%, 1.2 ppb, in ASG (6.3%, not quantified and in NSG (2.0%, not quantified. Clothianidin was only detected in ASG (6.3%, not quantified, and in NSG (2.0%, 1.6 ppb. Thiacloprid was detected in ASG (6.3%, 0.1 ppb. The cases in TSG with detection of N-desmethyl-acetamiprid and thiamethoxam were aged 5 to 62 years and 13 to 62 years, respectively. Detection of N-desmethyl-acetamiprid was associated with increased prevalence of the symptoms (odds ratio: 14, 95% confidence interval: 3.5-57. Urinary N-desmethyl-acetamiprid can be used as a

  1. Advanced theoretical and experimental studies in automatic control and information systems. [including mathematical programming and game theory

    Science.gov (United States)

    Desoer, C. A.; Polak, E.; Zadeh, L. A.

    1974-01-01

    A series of research projects is briefly summarized which includes investigations in the following areas: (1) mathematical programming problems for large system and infinite-dimensional spaces, (2) bounded-input bounded-output stability, (3) non-parametric approximations, and (4) differential games. A list of reports and papers which were published over the ten year period of research is included.

  2. Variations of the accessory nerve: anatomical study including previously undocumented findings-expanding our misunderstanding of this nerve.

    Science.gov (United States)

    Tubbs, R Shane; Ajayi, Olaide O; Fries, Fabian N; Spinner, Robert J; Oskouian, Rod J

    2017-02-01

    The anatomy of the accessory nerve has been well described but continued new clinical and anatomical findings exemplify our lack of a full understanding of the course of this nerve. Therefore, this study aimed to expand on our knowledge of the course of the 11th cranial nerve via anatomical dissections. Fifty-six cadavers (112 sides) underwent dissection of the accessory nerve from its cranial and spinal origins to its emergence into the posterior cervical triangle. Immunohistochemistry was performed when appropriate. Our findings included two cases (1.8%) where the nerve was duplicated, one intracranially and one extracranially. One accessory nerve (0.9%) was found to enter its own dural compartment within the jugular foramen. The majority of sides (80%) were found to have a cranial root of the accessory nerve. Thirty-one sides (28%) had connections to cervical dorsal roots medially and three sides (2.7%) laterally. Medial connections were most common with the C1 nerve. Medial components of these dorsal root connections were all sensory in nature. However, lateral components were motor on two sides (1.8%). Nerves traveled anterior to the internal jugular vein on 88% of sides. One (0.9%) left side nerve joined an interneural anastomosis between the dorsal rootlets. Macroganglia were found on the spinal part of the intracranial nerve on 13% of sides. The lesser occipital nerve arose directly from the accessory nerve on two sides (1.8%) and communicated with the accessory nerve on 5.4% of sides. One side (0.9%) was found to communicate with the facial nerve with both nerves innervating the sternocleidomastoid muscle. Additional anatomical knowledge of the variants of the accessory nerve may benefit patient care when this nerve is pathologically involved.

  3. Vegetation response to invasive Tamarix control in southwestern U.S. rivers: A collaborative study including 416 sites

    Science.gov (United States)

    González, Eduardo; Sher, Anna A; Anderson, Robert M.; Bay, Robin F.; Bean, Daniel W.; Bissonnete, Gabriel J.; Bourgeois, Bérenger; Cooper, David J.; Dohrenwend, Kara; Eichhorst, Kim D.; El Waer, Hisham; Kennard, Deborah K.; Harms-Weissinger, Rebecca; Henry, Annie L.; Makarick, Lori J.; Ostoja, Steven M.; Reynolds, Lindsay V.; Robinson, W. Wright; Shafroth, Patrick B.

    2017-01-01

    Most studies assessing vegetation response following control of invasive Tamarix trees along southwestern U.S. rivers have been small in scale (e.g., river reach), or at a regional scale but with poor spatial-temporal replication, and most have not included testing the effects of a now widely used biological control. We monitored plant composition following Tamarix control along hydrologic, soil, and climatic gradients in 244 treated and 172 reference sites across six U.S. states. This represents the largest comprehensive assessment to date on the vegetation response to the four most common Tamarix control treatments. Biocontrol by a defoliating beetle (treatment 1) reduced the abundance of Tamarix less than active removal by mechanically using hand and chain-saws (2), heavy machinery (3) or burning (4). Tamarix abundance also decreased with lower temperatures, higher precipitation, and follow-up treatments for Tamarix resprouting. Native cover generally increased over time in active Tamarix removal sites, however, the increases observed were small and was not consistently increased by active revegetation. Overall, native cover was correlated to permanent stream flow, lower grazing pressure, lower soil salinity and temperatures, and higher precipitation. Species diversity also increased where Tamarix was removed. However, Tamarix treatments, especially those generating the highest disturbance (burning and heavy machinery), also often promoted secondary invasions of exotic forbs. The abundance of hydrophytic species was much lower in treated than in reference sites, suggesting that management of southwestern U.S. rivers has focused too much on weed control, overlooking restoration of fluvial processes that provide habitat for hydrophytic and floodplain vegetation. These results can help inform future management of Tamarix-infested rivers to restore hydrogeomorphic processes, increase native biodiversity and reduce abundance of noxious species.

  4. Genome-wide association study of alcohol dependence: significant findings in African- and European-Americans including novel risk loci

    Science.gov (United States)

    Gelernter, J; Kranzler, HR; Sherva, R; Almasy, L; Koesterer, R; Smith, AH; Anton, R; Preuss, UW; Ridinger, M; Rujescu, D; Wodarz, N; Zill, P; Zhao, H; Farrer, LA

    2014-01-01

    We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-American (AA) populations, with replication in independent samples of EAs, AAs and Germans. Our sample for discovery and replication was 16 087 subjects, the largest sample for AD GWAS to date. Numerous genome-wide significant (GWS) associations were identified, many novel. Most associations were population specific, but in several cases were GWS in EAs and AAs for different SNPs at the same locus, showing biological convergence across populations. We confirmed well-known risk loci mapped to alcohol-metabolizing enzyme genes, notably ADH1B (EAs: Arg48His, P = 1.17 × 10−31; AAs: Arg369Cys, P = 6.33 × 10−17) and ADH1C in AAs (Thr151Thr, P = 4.94 × 10−10), and identified novel risk loci mapping to the ADH gene cluster on chromosome 4 and extending centromerically beyond it to include GWS associations at LOC100507053 in AAs (P = 2.63 × 10−11), PDLIM5 in EAs (P = 2.01 × 10−8), and METAP in AAs (P = 3.35 × 10−8). We also identified a novel GWS association (1.17 × 10−10) mapped to chromosome 2 at rs1437396, between MTIF2 and CCDC88A, across all of the EA and AA cohorts, with supportive gene expression evidence, and population-specific GWS for markers on chromosomes 5, 9 and 19. Several of the novel associations implicate direct involvement of, or interaction with, genes previously identified as schizophrenia risk loci. Confirmation of known AD risk loci supports the overall validity of the study; the novel loci are worthy of genetic and biological follow-up. The findings support a convergence of risk genes (but not necessarily risk alleles) between populations, and, to a lesser extent, between psychiatric traits. PMID:24166409

  5. [Baseline characteristics and changes in treatment after a period of optimization of the patients included in the study EFICAR].

    Science.gov (United States)

    Gómez-Marcos, Manuel A; Agudo-Conde, Cristina; Torcal, Jesús; Echevarria, Pilar; Domingo, Mar; Arietaleanizbeascoa, María; Sanz-Guinea, Aitor; de la Torre, Maria M; Ramírez, Jose I; García-Ortiz, Luis

    2016-03-01

    To describe the baseline date and drugs therapy changes during treatment optimization in patients with heart failure with depressed systolic function included in the EFICAR study. Multicenter randomized clinical trial. Seven Health Centers. 150 patients (ICFSD) age 68±10 years, 77% male. Sociodemographic variables, comorbidities (Charlson index), functional capacity and quality of life. Drug therapy optimization was performed. The main etiology was ischemic heart disease (45%), with 89% in functional class II. The Charlson index was 2.03±1.05. The ejection fraction mean was 37%±8, 19% with ejection fraction <30%. With the stress test 6.3±1.6 mean was reached, with the 6 minutes test 446±78 meters and the chair test 13.7±4.4 seconds. The overall quality of life with ejection fraction was 22.8±18.7 and with the Short Form-36 Health Survey, physical health 43.3±8.4 and mental health 50.1±10.6. After optimizing the treatment, the percentage of patients on drugs therapy and the dose of angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists and beta-blockers were not changed. The majority of the subjects are in functional class II, with functional capacity and quality of life decreased and comorbidity index high. A protocolized drug therapy adjustment did not increase the dose or number of patients with effective drugs for heart failure with depressed systolic function. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  6. Wave propagation against current : a study of the effects of vertical shears of the mean current on the geometrical focusing of water waves

    Science.gov (United States)

    Charland, Jenna; Touboul, Julien; Rey, Vincent

    2013-04-01

    Wave propagation against current : a study of the effects of vertical shears of the mean current on the geometrical focusing of water waves J. Charland * **, J. Touboul **, V. Rey ** jenna.charland@univ-tln.fr * Direction Générale de l'Armement, CNRS Délégation Normandie ** Université de Toulon, 83957 La Garde, France Mediterranean Institute of Oceanography (MIO) Aix Marseille Université, 13288 Marseille, France CNRS/INSU, IRD, MIO, UM 110 In the nearshore area, both wave propagation and currents are influenced by the bathymetry. For a better understanding of wave - current interactions in the presence of a 3D bathymetry, a large scale experiment was carried out in the Ocean Basin FIRST, Toulon, France. The 3D bathymetry consisted of two symmetric underwater mounds on both sides in the mean wave direction. The water depth at the top the mounds was hm=1,5m, the slopes of the mounds were of about 1:3, the water depth was h=3 m elsewhere. For opposite current conditions (U of order 0.30m/s), a huge focusing of the wave up to twice its incident amplitude was observed in the central part of the basin for T=1.4s. Since deep water conditions are verified, the wave amplification is ascribed to the current field. The mean velocity fields at a water depth hC=0.25m was measured by the use of an electromagnetic current meter. The results have been published in Rey et al [4]. The elliptic form of the "mild slope" equation including a uniform current on the water column (Chen et al [1]) was then used for the calculations. The calculated wave amplification of factor 1.2 is significantly smaller than observed experimentally (factor 2). So, the purpose of this study is to understand the physical processes which explain this gap. As demonstrated by Kharif & Pelinovsky [2], geometrical focusing of waves is able to modify significantly the local wave amplitude. We consider this process here. Since vertical velocity profiles measured at some locations have shown significant

  7. Reliability of Current Biokinetic and Dosimetric Models for Radionuclides: A Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    Leggett, Richard Wayne [ORNL; Eckerman, Keith F [ORNL; Meck, Robert A. [U.S. Nuclear Regulatory Commission

    2008-10-01

    This report describes the results of a pilot study of the reliability of the biokinetic and dosimetric models currently used by the U.S. Nuclear Regulatory Commission (NRC) as predictors of dose per unit internal or external exposure to radionuclides. The study examines the feasibility of critically evaluating the accuracy of these models for a comprehensive set of radionuclides of concern to the NRC. Each critical evaluation would include: identification of discrepancies between the models and current databases; characterization of uncertainties in model predictions of dose per unit intake or unit external exposure; characterization of variability in dose per unit intake or unit external exposure; and evaluation of prospects for development of more accurate models. Uncertainty refers here to the level of knowledge of a central value for a population, and variability refers to quantitative differences between different members of a population. This pilot study provides a critical assessment of models for selected radionuclides representing different levels of knowledge of dose per unit exposure. The main conclusions of this study are as follows: (1) To optimize the use of available NRC resources, the full study should focus on radionuclides most frequently encountered in the workplace or environment. A list of 50 radionuclides is proposed. (2) The reliability of a dose coefficient for inhalation or ingestion of a radionuclide (i.e., an estimate of dose per unit intake) may depend strongly on the specific application. Multiple characterizations of the uncertainty in a dose coefficient for inhalation or ingestion of a radionuclide may be needed for different forms of the radionuclide and different levels of information of that form available to the dose analyst. (3) A meaningful characterization of variability in dose per unit intake of a radionuclide requires detailed information on the biokinetics of the radionuclide and hence is not feasible for many infrequently

  8. Fast Food Pattern and Cardiometabolic Disorders: A Review of Current Studies.

    Science.gov (United States)

    Bahadoran, Zahra; Mirmiran, Parvin; Azizi, Fereidoun

    2015-01-01

    There are growing concern globally regarding the alarming trend of fast food consumption and its related cardiometabolic outcomes including overweight and obesity. This study aimed to review the current evidences available in relation to adverse effects of fast food pattern on cardiometa-bolic risk factors. Relevant articles including epidemiological and clinical studies with appropriate design and good quality were obtained through searches of the Medline, PubMed, Scopus databases and Google scholar with related key words including "fast foods", "processed foods", "obesity", "overweight", "insulin resistance", "diabetes", "cardiovascular disease", "metabolic syndrome", "dyslipidemia" and "hypertension". Fast food consumption and out-of-home eating behavior is a main risk factor for lower diet quality, higher calorie and fat intake and lower micronutrients density of diet. Frequent consumption of fast foods was accompanied with overweight and abdominal fat gain, impaired insulin and glucose homeostasis, lipid and lipoprotein disorders, induction of systemic inflammation and oxidative stress. Higher fast food consumption also increases the risk of developmental diabetes, metabolic syndrome and cardiovascular disease. This review provides further evidence warning us against the irreparable effects of fast food consumption on public health especially the increasing global burden of obesity and cardiovascu-lar diseases.

  9. Fast Food Pattern and Cardiometabolic Disorders: A Review of Current Studies

    Directory of Open Access Journals (Sweden)

    Zahra Bahadoran

    2015-12-01

    Full Text Available Background: There are growing concern globally regarding the alarming trend of fast food consump­tion and its related cardiometabolic outcomes including overweight and obesity. This study aimed to review the current evidences available in relation to adverse effects of fast food pattern on cardiometa­bolic risk factors. Methods: Relevant articles including epidemiological and clinical studies with appropriate design and good quality were obtained through searches of the Medline, PubMed, Scopus databases and Google scholar with related key words including "fast foods", "processed foods", "obesity", "overweight", "insulin resistance", "diabetes", "cardiovascular disease", "metabolic syndrome", "dyslipidemia" and "hypertension". Results: Fast food consumption and out-of-home eating behavior is a main risk factor for lower diet quality, higher calorie and fat intake and lower micronutrients density of diet. Frequent consumption of fast foods was accompanied with overweight and abdominal fat gain, impaired insulin and glucose homeostasis, lipid and lipoprotein disorders, induction of systemic inflammation and oxidative stress. Higher fast food consumption also increases the risk of developmental diabetes, metabolic syndrome and cardiovascular disease. Conclusion: This review provides further evidence warning us against the irreparable effects of fast food consumption on public health especially the increasing global burden of obesity and cardiovascu­lar diseases.

  10. Effect of yoga regimen on lung functions including diffusion capacity in coronary artery disease patients: A randomized controlled study.

    Science.gov (United States)

    Yadav, Asha; Singh, Savita; Singh, Kp; Pai, Preeti

    2015-01-01

    Lung functions are found to be impaired in coronary artery disease (CAD), congestive heart failure, left ventricular dysfunction, and after cardiac surgery. Diffusion capacity progressively worsens as the severity of CAD increases due to reduction in lung tissue participating in gas exchange. Pranayama breathing exercises and yogic postures may play an impressive role in improving cardio-respiratory efficiency and facilitating gas diffusion at the alveolo-capillary membrane. This study was done to see the effect of yoga regimen on lung functions particularly diffusion capacity in CAD patients. A total of 80 stable CAD patients below 65 years of age of both sexes were selected and randomized into two groups of 40 each. Group I CAD patients were given yoga regimen for 3 months which consisted of yogic postures, pranayama breathing exercises, dietary modification, and holistic teaching along with their conventional medicine while Group II CAD patients were put only on conventional medicine. Lung functions including diffusion capacity were recorded thrice in both the groups: 0 day as baseline, 22(nd) day and on 90(th) day by using computerized MS medisoft Cardio-respiratory Instrument, HYP'AIR Compact model of cardio-respiratory testing machine was manufactured by P K Morgan, India. The recorded parameters were statistically analyzed by repeated measures ANOVA followed by Tukey's test in both the groups. Cardiovascular parameters were also compared before and after intervention in both the groups. Statistically significant improvements were seen in slow vital capacity, forced vital capacity, peak expiratory flow rate, maximum voluntary ventilation, and diffusion factor/ transfer factor of lung for carbon monoxide after 3 months of yoga regimen in Group I. Forced expiratory volume in 1(st) sec (FEV1), and FEV1 % also showed a trend toward improvement although not statistically significant. HR, SBP and DBP also showed significant improvement in Group-I patients who

  11. Drug interaction studies on new drug applications: current situations and regulatory views in Japan.

    Science.gov (United States)

    Nagai, Naomi

    2010-01-01

    Drug interaction studies on new drug applications (NDAs) for new molecular entities (NMEs) approved in Japan between 1997 and 2008 are examined in the Pharmaceuticals and Medical Devices Agency (PMDA). The situations of drug interaction studies in NDAs have changed over the past 12 years, especially in metabolizing enzyme and transporter-based drug interactions. Materials and approaches to study drug-metabolizing enzyme-based drug interactions have improved, and become more rational based on mechanistic theory and new technologies. On the basis of incremental evidence of transporter roles in human pharmacokinetics, transporter-based drug interactions have been increasingly studied during drug development and submitted in recent NDAs. Some recently approved NMEs include transporter-based drug interaction information in their package inserts (PIs). The regulatory document "Methods of Drug Interaction Studies," in addition to recent advances in science and technology, has also contributed to plan and evaluation of drug interaction studies in recent new drug development. This review summarizes current situations and further discussion points on drug interaction studies in NDAs in Japan.

  12. Study on traffic states and jamming transitions for two-lane highway including a bus by using a model with calibrated optimal velocity function

    Science.gov (United States)

    Li, Zhipeng; Yi, Yi

    2014-07-01

    In this paper, traffic states and jamming transitions on two-lane highway including a bus are studied by using a car following model with a calibrated optimal velocity function. We derive a new flow-density diagram with four distinctly separated traffic states, which is different from that of the earlier study obtained by applying the OVM with theoretical optimal velocity function. The spatio-temporal diagrams are presented to illustrate phase characteristics of each traffic state. It is found that the phase characteristic features of two of four states are different from any state of the earlier result, and traffic flow of state 2 and state 3 can reproduce some characteristics observed from empirical investigations such as centralized lane-changing, hanging tail of cluster, and synchronized flow. In addition, we have clarified the lane-changing behaviors and their effects on two-lane traffic flow including a bus. It is shown that the velocity oscillations behind the bus can help the lane-changing in state 2 and the behaviors of lane-changing are the important reason of forming of the synchronized flow in state 3. It is also concluded that lane-changing can only improve the current in the region of middle density.

  13. His Story/Her Story: A Dialogue About Including Men and Masculinities in the Women's Studies Curriculum

    Science.gov (United States)

    Berila, Beth; Keller, Jean; Krone, Camilla; Laker, Jason; Mayers, Ozzie

    2005-01-01

    In section I of this article, Beth Berila, director of Women's Studies at Saint Cloud State University (SCSU), St. Cloud, Minnesota, provides a theoretical argument for incorporating Gender Studies into Women's Studies programs, drawing on recent analyses in feminist studies, queer theory, critical race theory, and transnational feminism. In…

  14. Effect of Direct Electricity Current on Viability of Leishmania (L tropica Promastigotes: an in vitro Study

    Directory of Open Access Journals (Sweden)

    M Malek

    2016-01-01

    Full Text Available Introduction: Leishmaniasis is among top ten infectious diseases in the world, including the three diseases is important that the development of vaccines, medicines and insecticides is difficult to control it. The aim of in this study was Effect of direct electricity current on viability of Leishmania (L tropica promastigotes: an In vitro study. Methods: Leishmania (L tropica [MHOM / IR / NADIM3] to an appropriate level in NNN medium and RPMI1640 culture and promastigotes was prepared both stationary and logarithmic phases. The effects of the direct current from the electrodes 2 or 4 cm Leishmania parasite when staining the size of 1 × 1/5 cm in a arose gel and the parasites create both stationary and logarithmic phases were separate. Electrodes are 2 or 4 cm, and when the voltage in the order of 2/5, 3/5 and 4/5 was applied to the electrodes at 5, 10, 15, 20, 25, 30, 35 and 70 minutes.   Results: Mean number of live promastigotes stationary and logarithmic stages when the distance between the electrodes was 2 cm to voltage 2/5, 3/5 and 4/5 compared with promastigotes in the control group showed significant differences (P=0.003. Also mean number of live promastigotes static stage when the distance between the electrodes was 4 cm to voltage 2/5 and 3/5 V was not significant (P=0.148. And 3/5 and 4/5 volts for voltage are not significant (P>0.05, the mean number of live promastigotes logarithmic stage when the distance between the electrodes was 4 cm, the voltage difference between the number of parasites for 2/5 and 3/5 V  Not significant (P=0.725. Conclusion: The electrodes are more sensitive and dynamic stage promastigotes lower and higher voltage electric current effect on growth control well.

  15. Current debates on end-of-life sedation: an international expert elicitation study.

    Science.gov (United States)

    Papavasiliou, Evangelia Evie; Payne, Sheila; Brearley, Sarah

    2014-08-01

    End-of-life sedation, though increasingly prevalent and widespread internationally, remains one of the most highly debated medical practices in the context of palliative medicine. This qualitative study aims to elicit and record the perspectives of leading international palliative care experts on current debates. Twenty-one professionals from diverse backgrounds, sharing field-specific knowledge/expertise defined by significant scholarly contribution on end-of-life sedation, were recruited. Open-ended, semi-structured interviews, following a topic-oriented structure reflecting on current debates, were conducted. Results were analysed using thematic content analysis. Three main aspects of sedation were identified and discussed as potentially problematic: (a) continuous deep sedation as an extreme facet of end-of-life sedation, (b) psycho-existential suffering as an ambivalent indication for sedation and (c) withdrawal or withholding of artificial nutrition and hydration as potentially life-shortening. On these grounds, concerns were reported over end-of-life sedation being morally equivalent to euthanasia. Considerable emphasis was placed on intentions as the distinguishing factor between end-of-life acts, and protective safeguards were introduced to distance sedation from euthanasia. This study shows that, despite the safeguards introduced, certain aspects of sedation, including the intentions associated with the practice, are still under question, parallels being drawn between end-of-life sedation and euthanasia. This reaffirms the existence of a grey area surrounding the two practices, already evidenced in countries where euthanasia is legalized. More clarity over the issues that generate this grey area, with their causes being uncovered and eliminated, is imperative to resolve current debates and effectively inform research, policy and practice of end-of-life sedation.

  16. Stuttering in Lima, Peru: a qualitative case study of current concepts, theories, and treatment facilities.

    Science.gov (United States)

    Gorin, L C

    1980-07-01

    The purpose of this study was to investigate within an ethnographic framework, certain cultural variables which may be factors in the etiology and presentation of stuttering as well as in the care provided for those who stutter. An assessment was made of the cultural influences upon the following variables of the transcultural investigation of stuttering: 1) epidemiological characteristics of stuttering; 2) attitudes of the stutterer and the stutterer's family, friends, therapists towards the defect; 3) cultural expectations which may be part of the etiology/perpetuation of the problem of stuttering, including an examination of these cultural expectations within the context of the stutterer's past and present home, work, and recreational lifestyles: 4) current theories and therapies.

  17. A new approach to study the effect of generation rate on drain-source current of bilayer graphene transistors

    Science.gov (United States)

    Ahmad, H.; Ghadiry, M.; AbdManaf, A.

    2016-10-01

    This paper presents a new approach to study the effect of impact ionization on the current of bilayer graphene field effect transistors. Analytical models for surface potential and current together with a Monte Carlo approach which include the edge effect scattering are used to calculate the current and generation rate in bilayer graphene transistors due to ionization. FlexPDE simulation is also employed for verification of surface potential modeling. Using the approach, the profile of generation rate, surface potential and current are plotted with respect to several structural parameters. We have shown that ignoring this effect in the modeling will result in an error of up to 10 % for a typical 30 nm bilayer graphene field effect transistor. As a result, we conclude that any analytical study ignoring the ionization is incomplete for bilayer graphene field effect transistors. The model presented here can be applied in optimization of photo detectors based on graphene.

  18. Maintaining turbidity and current flow in laboratory aquarium studies, a case study using Sabellaria spinulosa

    DEFF Research Database (Denmark)

    Davies, Andrew J.; S. Last, Kim; Attard, Karl

    2009-01-01

    Many aquatic organisms rely on the suspension of particulate matter for food or for building materials, yet these conditions are difficult to replicate in laboratory mesocosms. Consequently, husbandry and experimental conditions may often be sub-optimal. The Vortex Resuspension Tank (Vo......RT) is a simple and reliable system for the resuspension of food or sediments using an enclosed airlift. The particle rain from the lift is mixed in the tank by two water inputs that provide directional current flow across the study organism(s). The vortex mixing creates a turbulent lateral water flow that allows...... whereas under intermediate and high sediment rates there was consistent cumulative growth throughout a 15 d experiment. This highlights the importance of suspended sediment for S. spinulosa and also the suitability of the VoRT system for maintaining organisms with suspended matter requirements....

  19. Studies and analyses of the management of scientific research and development, including implementation and application at NASA centers

    Science.gov (United States)

    Rubenstein, A. H.

    1975-01-01

    Summary results obtained through the Program of Research on the Management of Research and Development (POMRAD) were presented. The nature of the overall program and the specific projects undertaken were described. Statistical data is also given concerning the papers, publications, people, and major program areas associated with the program. The actual list of papers, names of doctoral and masters theses, and other details of the program are included as appendices.

  20. Statistical methods for meta-analyses including information from studies without any events-add nothing to nothing and succeed nevertheless.

    Science.gov (United States)

    Kuss, O

    2015-03-30

    Meta-analyses with rare events, especially those that include studies with no event in one ('single-zero') or even both ('double-zero') treatment arms, are still a statistical challenge. In the case of double-zero studies, researchers in general delete these studies or use continuity corrections to avoid them. A number of arguments against both options has been given, and statistical methods that use the information from double-zero studies without using continuity corrections have been proposed. In this paper, we collect them and compare them by simulation. This simulation study tries to mirror real-life situations as completely as possible by deriving true underlying parameters from empirical data on actually performed meta-analyses. It is shown that for each of the commonly encountered effect estimators valid statistical methods are available that use the information from double-zero studies without using continuity corrections. Interestingly, all of them are truly random effects models, and so also the current standard method for very sparse data as recommended from the Cochrane collaboration, the Yusuf-Peto odds ratio, can be improved on. For actual analysis, we recommend to use beta-binomial regression methods to arrive at summary estimates for the odds ratio, the relative risk, or the risk difference. Methods that ignore information from double-zero studies or use continuity corrections should no longer be used. We illustrate the situation with an example where the original analysis ignores 35 double-zero studies, and a superior analysis discovers a clinically relevant advantage of off-pump surgery in coronary artery bypass grafting. Copyright © 2014 John Wiley & Sons, Ltd.

  1. Development and Field-Testing of a Study Protocol, including a Web-Based Occupant Survey Tool, for Use in Intervention Studies of Indoor Environmental Quality

    Energy Technology Data Exchange (ETDEWEB)

    Mendell, Mark; Eliseeva, Ekaterina; Spears, Michael; Fisk, William J.

    2009-06-01

    We developed and pilot-tested an overall protocol for intervention studies to evaluate the effects of indoor environmental changes in office buildings on the health symptoms and comfort of occupants. The protocol includes a web-based survey to assess the occupant's responses, as well as specific features of study design and analysis. The pilot study, carried out on two similar floors in a single building, compared two types of ventilation system filter media. With support from the building's Facilities staff, the implementation of the filter change intervention went well. While the web-based survey tool worked well also, low overall response rates (21-34percent among the three work groups included) limited our ability to evaluate the filter intervention., The total number of questionnaires returned was low even though we extended the study from eight to ten weeks. Because another simultaneous study we conducted elsewhere using the same survey had a high response rate (>70percent), we conclude that the low response here resulted from issues specific to this pilot, including unexpected restrictions by some employing agencies on communication with occupants.

  2. Development and Field-Testing of a Study Protocol, including a Web-Based Occupant Survey Tool, for Use in Intervention Studies of Indoor Environmental Quality

    Energy Technology Data Exchange (ETDEWEB)

    Mendell, Mark; Eliseeva, Ekaterina; Spears, Michael; Fisk, William J.

    2009-06-01

    We developed and pilot-tested an overall protocol for intervention studies to evaluate the effects of indoor environmental changes in office buildings on the health symptoms and comfort of occupants. The protocol includes a web-based survey to assess the occupant's responses, as well as specific features of study design and analysis. The pilot study, carried out on two similar floors in a single building, compared two types of ventilation system filter media. With support from the building's Facilities staff, the implementation of the filter change intervention went well. While the web-based survey tool worked well also, low overall response rates (21-34percent among the three work groups included) limited our ability to evaluate the filter intervention., The total number of questionnaires returned was low even though we extended the study from eight to ten weeks. Because another simultaneous study we conducted elsewhere using the same survey had a high response rate (>70percent), we conclude that the low response here resulted from issues specific to this pilot, including unexpected restrictions by some employing agencies on communication with occupants.

  3. The Current Studies of Education for a Traditional and Complementary Medicine in Malaysia.

    Science.gov (United States)

    Kim, Yun Jin

    2017-01-01

    The aim of this study is to understand the current tradition and complementary medicine (T&CM) education in Malaysia. We referred to literature regarding to traditional medicine education in Malaysia, and collected the information via website or interview with faculty of T&CM in universities/colleges and Division of T&CM, Ministry of Health, Malaysia. T&CM education in Malaysia has been following China's T&CM systems for 50 years. Currently, Division of T&CM, Ministry of Health; and Ministry of Higher Education has approved 11 institutions to offer T&CM education. Students may major in Chinese herbal medicine, acupuncture, or other T&CM subjects. Generally, clinical training programs in China, Taiwan, or Australia include substantial proportion of clinical training. We report on the general information of T&CM education in Malaysia. This result would be the first-stage information for the establishment of a strategy regarding the enhancement of T&CM education in Malaysia.

  4. A comparative study: the impact of different lipid extraction methods on current microalgal lipid research.

    Science.gov (United States)

    Li, Yan; Ghasemi Naghdi, Forough; Garg, Sourabh; Adarme-Vega, Tania Catalina; Thurecht, Kristofer J; Ghafor, Wael Abdul; Tannock, Simon; Schenk, Peer M

    2014-01-24

    Microalgae cells have the potential to rapidly accumulate lipids, such as triacylglycerides that contain fatty acids important for high value fatty acids (e.g., EPA and DHA) and/or biodiesel production. However, lipid extraction methods for microalgae cells are not well established, and there is currently no standard extraction method for the determination of the fatty acid content of microalgae. This has caused a few problems in microlagal biofuel research due to the bias derived from different extraction methods. Therefore, this study used several extraction methods for fatty acid analysis on marine microalga Tetraselmis sp. M8, aiming to assess the potential impact of different extractions on current microalgal lipid research. These methods included classical Bligh & Dyer lipid extraction, two other chemical extractions using different solvents and sonication, direct saponification and supercritical CO₂ extraction. Soxhlet-based extraction was used to weigh out the importance of solvent polarity in the algal oil extraction. Coupled with GC/MS, a Thermogravimetric Analyser was used to improve the quantification of microalgal lipid extractions. Among these extractions, significant differences were observed in both, extract yield and fatty acid composition. The supercritical extraction technique stood out most for effective extraction of microalgal lipids, especially for long chain unsaturated fatty acids. The results highlight the necessity for comparative analyses of microalgae fatty acids and careful choice and validation of analytical methodology in microalgal lipid research.

  5. Exploring Current Sensory Enhancement Practices Within Videofluoroscopic Swallow Study (VFSS) Clinics.

    Science.gov (United States)

    Turkington, Leisa; Nund, Rebecca L; Ward, Elizabeth C; Farrell, Anna

    2017-04-01

    Whilst some research evidence supports the potential benefits of sensory enhancement strategies (SES) in dysphagia management, there is limited understanding of how SES are used in clinical services and the influencing drivers involved in selection during instrumental assessment. SES include modification of temperature, flavour, texture, chemesthetic qualities and bolus size of food/fluid. This study aimed to explore the use of SES within Australian Videofluoroscopic Swallow Study (VFSS) clinics providing adult services, via a qualitative methodology. Maximum variation sampling was used to select a cross section of speech-language pathologists (SLPs) with a range of experience working within 16 VFSS clinics across metropolitan and regional settings to participate in semi-structured, focus group or individual teleconference interviews. Content analysis of interview transcripts was conducted, with four themes emerging as influencing drivers of SES use, including: Patient factors influence SES use; Clinician factors influence SES use; Trials of SES require planning and organisation, and; Organisational barriers impact on SES use. These four themes were all connected through a single integrative theme: Extensive variations of SES procedures exist across clinical settings. Findings indicate that achieving alignment of clinical purpose and implementation of practices amongst VFSS clinicians will be complex given current diversity in SES use. Organisational issues and clinician training need to be addressed, and more research is needed to provide a stronger evidence base to inform clinical practice in this emerging area of dysphagia management.

  6. Detailed diesel exhaust characteristics including particle surface area and lung deposited dose for better understanding of health effects in human chamber exposure studies

    Science.gov (United States)

    Wierzbicka, Aneta; Nilsson, Patrik T.; Rissler, Jenny; Sallsten, Gerd; Xu, Yiyi; Pagels, Joakim H.; Albin, Maria; Österberg, Kai; Strandberg, Bo; Eriksson, Axel; Bohgard, Mats; Bergemalm-Rynell, Kerstin; Gudmundsson, Anders

    2014-04-01

    Several diesel exhaust (DE) characteristics, comprising both particle and gas phase, recognized as important when linking with health effects, are not reported in human chamber exposure studies. In order to understand effects of DE on humans there is a need for better characterization of DE when performing exposure studies. The aim of this study was to determine and quantify detailed DE characteristics during human chamber exposure. Additionally to compare to reported DE properties in conducted human exposures. A wide battery of particle and gas phase measurement techniques have been used to provide detailed DE characteristics including the DE particles (DEP) surface area, fraction and dose deposited in the lungs, chemical composition of both particle and gas phase such as NO, NO2, CO, CO2, volatile organic compounds (including aldehydes, benzene, toluene) and polycyclic aromatic hydrocarbons (PAHs). Eyes, nose and throat irritation effects were determined. Exposure conditions with PM1 (<1 μm) mass concentration 280 μg m-3, number concentration 4 × 105 cm-3 and elemental to total carbon fraction of 82% were generated from a diesel vehicle at idling. When estimating the lung deposited dose it was found that using the size dependent effective density (in contrast to assuming unity density) reduced the estimated respiratory dose by 132% by mass. Accounting for agglomerated structure of DEP prevented underestimation of lung deposited dose by surface area by 37% in comparison to assuming spherical particles. Comparison of DE characteristics reported in conducted chamber exposures showed that DE properties vary to a great extent under the same DEP mass concentration and engine load. This highlights the need for detailed and standardized approach for measuring and reporting of DE properties. Eyes irritation effects, most probably caused by aldehydes in the gas phase, as well as nose irritation were observed at exposure levels below current occupational exposure limit

  7. Study protocol: rehabilitation including social and physical activity and education in children and teenagers with cancer (RESPECT)

    OpenAIRE

    Thorsteinsson, Troels; Helms, Anne Sofie; Adamsen, Lis; Andersen, Lars Bo; Andersen, Karen Vitting; Christensen, Karl Bang; Halse, Henrik; Heilmann, Carsten; Hejgaard, Nete; Johansen, Christoffer; Madsen, Marianne; Madsen, Svend Aage; Simovska, Venka; Strange, Birgit; Thing, Lone Friis

    2013-01-01

    Background During cancer treatment children have reduced contact with their social network of friends, and have limited participation in education, sports, and leisure activities. During and following cancer treatment, children describe school related problems, reduced physical fitness, and problems related to interaction with peers. Methods/design The RESPECT study is a nationwide population-based prospective, controlled, mixed-methods intervention study looking at children aged 6-18 years n...

  8. The current status of usability studies of information technologies in China: a systematic study.

    Science.gov (United States)

    Lei, Jianbo; Xu, Lufei; Meng, Qun; Zhang, Jiajie; Gong, Yang

    2014-01-01

    To systematically review and analyze the current status and characteristics of usability studies in China in the field of information technology in general and in the field of healthcare in particular. We performed a quantitative literature analysis in three major Chinese academic databases and one English language database using Chinese search terms equivalent to the concept of usability. Six hundred forty-seven publications were selected for analysis. We found that in China the literature on usability in the field of information technology began in 1994 and increased thereafter. The usability definitions from ISO 9241-11:1998 and Nielsen (1993) have been widely recognized and cited. Authors who have published several publications are rare. Fourteen journals have a publishing rate over 1%. Only nine publications about HIT were identified. China's usability research started relatively late. There is a lack of organized research teams and dedicated usability journals. High-impact theoretical studies are scarce. On the application side, no original and systematic research frameworks have been developed. The understanding and definition of usability is not well synchronized with international norms. Besides, usability research in HIT is rare. More human and material resources need to be invested in China's usability research, particularly in HIT.

  9. The Current Status of Usability Studies of Information Technologies in China: A Systematic Study

    Directory of Open Access Journals (Sweden)

    Jianbo Lei

    2014-01-01

    Full Text Available Objectives. To systematically review and analyze the current status and characteristics of usability studies in China in the field of information technology in general and in the field of healthcare in particular. Methods. We performed a quantitative literature analysis in three major Chinese academic databases and one English language database using Chinese search terms equivalent to the concept of usability. Results. Six hundred forty-seven publications were selected for analysis. We found that in China the literature on usability in the field of information technology began in 1994 and increased thereafter. The usability definitions from ISO 9241-11:1998 and Nielsen (1993 have been widely recognized and cited. Authors who have published several publications are rare. Fourteen journals have a publishing rate over 1%. Only nine publications about HIT were identified. Discussions. China’s usability research started relatively late. There is a lack of organized research teams and dedicated usability journals. High-impact theoretical studies are scarce. On the application side, no original and systematic research frameworks have been developed. The understanding and definition of usability is not well synchronized with international norms. Besides, usability research in HIT is rare. Conclusions. More human and material resources need to be invested in China’s usability research, particularly in HIT.

  10. Study of eddy current power loss in an RCS vacuum chamber

    Institute of Scientific and Technical Information of China (English)

    XU Shou-Yan; WANG Sheng

    2012-01-01

    In a Rapid Cycling Synchrotron (RCS),power loss due to an eddy current on the metal vacuum chamber would cause heating of the vacuum chamber.It is important to study the effect for estimating eddy current induced power loss and temperature growth.Analytical formulas for eddy current power loss for various types of vacuum chambers are derived for dipole and quadrupole repectively.By using the prototype of dipole of CSNS/RCS,an experiment was done to test the analytical formula.The derived formulas were applied to calculating the eddy current power loss on some special structures of an RCS vacuum chamber.

  11. Effective time-independent studies on resonance Raman spectroscopy of trans-stilbene including the Duschinsky effect

    Science.gov (United States)

    Lin, Na; Barone, Vincenzo; Cappelli, Chiara; Zhao, Xian; Ruud, Kenneth; Santoro, Fabrizio

    2013-07-01

    We simulate the resonance Raman spectra of trans-stilbene using a recently developed time-independent method that allows computations of the full two-dimensional spectrum as a function of the incident and scattered frequencies, including both the Franck-Condon and the Herzberg-Teller contributions. The potential energy surfaces (PESs) of the ground and resonant states are described in the harmonic approximation using density functional theory PBE0/6-31+G(d,p) calculations in gas phase and in cyclohexane. The simulated spectra are in good agreement with the experimental data [J. Chem. Phys. 83, 5000 (1985)] measured at four different excitation wavelengths, and allow us to unambiguously assign the main experimental bands. We perform an extensive comparison of the performance of four different vertical or adiabatic models for the PES of the resonant state, dissecting the effects of nuclear displacements and Duschinsky mixings on the spectra.

  12. Parents' views of including young boys in the Swedish national school-based HPV vaccination programme: a qualitative study

    Science.gov (United States)

    Gottvall, Maria; Stenhammar, Christina; Grandahl, Maria

    2017-01-01

    Objective To explore parents' views of extending the human papillomavirus (HPV) vaccination programme to also include boys. Design Explorative qualitative design using individual, face-to-face, interviews and inductive thematic analysis. Setting 11 strategically chosen municipalities in central Sweden. Participants Parents (n=42) who were offered HPV vaccination for their 11–12 years old daughter in the national school-based vaccination programme. Results The key themes were: equality from a public health perspective and perception of risk for disease. Parents expressed low knowledge and awareness about the health benefits of male HPV vaccination, and they perceived low risk for boys to get HPV. Some parents could not see any reason for vaccinating boys. However, many parents preferred gender-neutral vaccination, and some of the parents who had not accepted HPV vaccination for their daughter expressed that they would be willing to accept vaccination for their son, if it was offered. It was evident that there was both trust and distrust in authorities' decision to only vaccinate girls. Parents expressed a preference for increased sexual and reproductive health promotion such as more information about condom use. Some parents shared that it was more important to vaccinate girls than boys since they believed girls face a higher risk of deadly diseases associated with HPV, but some also believed girls might be more vulnerable to side effects of the vaccine. Conclusions A vaccine offered only to girls may cause parents to be hesitant to vaccinate, while also including boys in the national vaccination programme might improve parents' trust in the vaccine. More information about the health benefits of HPV vaccination for males is necessary to increase HPV vaccination among boys. This may eventually lead to increased HPV vaccine coverage among both girls and boys. PMID:28246143

  13. Transcranial direct current stimulation in the recovery of postural control after stroke: a pilot study.

    Science.gov (United States)

    Saeys, Wim; Vereeck, Luc; Lafosse, Christophe; Truijen, Steven; Wuyts, Floris L; Van De Heyning, Paul

    2015-01-01

    This pilot study aimed to evaluate the effectiveness of multiple sessions of transcranial Direct Current Stimulation (tDCS) during 4 weeks on balance and gait parameters after stroke. Thirty-one stroke patients were included in this randomised, double-blind, sham-controlled crossover study. The Tinetti test was used to assess functional balance and gait after stroke. Secondary measures, Rivermead Motor Assessment (RMA) and Trunk Impairment Scale (TIS), were registered to asses both motricity and trunk performance. All tests were administered at baseline, after 4 and 8 weeks. Patients were randomly divided into two groups. Both groups received both sixteen 20-min sessions of tDCS and sixteen 20-min sessions of Sham stimulation. Application method between groups was changed after 4 weeks. A general linear repeated measures model was used to analyse the results of our study. Results revealed an effect on the total score of the Tinetti test (p = 0.049). No significant results were obtained for the RMA (p = 0.166) and the TIS (p = 0.479). This pilot study indicates that 16 tDCS-sessions could have a beneficial effect on balance and gait in stroke patients measured with the Tinetti test. However, further research is needed to elucidate these findings. Implications for Rehabilitation Sixteen sessions of tDCS is beneficial in the recovery of postural control in stroke patients. tDCS has to be applied as soon as possible to enhance beneficial effects.

  14. Including Remote Participants and Artifacts: Visual, Audio, and Tactile Modalities in an Ethnographic Study of Globally Distributed Engineers

    DEFF Research Database (Denmark)

    Bjørn, Pernille; Pederson, Thomas

    2011-01-01

    In this paper we study how globally distributed Danish and Indian engineers co-construct and reconfigure a shared socio-technical collaborative place for global collaborative interaction: War Room meetings. We investigate the empirical case of War Room meetings based on three modalities in which ...

  15. Theoretical study on the low-lying excited states of the phosphorus monoiodide (PI) including the spin-orbit coupling

    Science.gov (United States)

    Zhang, Xiaomei; Liu, Xiaoting; Liang, Guiying; Li, Rui; Xu, Haifeng; Yan, Bing

    2016-01-01

    The potential energy curves (PECs) of the 22 Λ-S states of the phosphorus monoiodide (PI) molecule have been calculated at the level of MRCI+Q method with correlation-consistent quadruple-ζ quality basis set. The spectroscopic constants of the bound states are determined, which well reproduce the available measurements. The metastable a1Δ state has been reported for the first time, which lies between the X3Σ- and b1Σ+ states and have much deeper well than the ground state. The R-dependent spin-orbit (SO) matrix elements are calculated with the full-electron Breit-Pauli operator. Based on the SO matrix elements, the perturbations that the 23Π state may suffer from are analyzed in detail. The SOC effect makes the original Λ-S states split into 51 Ω states. In the zero-field splitting of the ground state X3Σ-, the spin-spin coupling contribution (2.23 cm-1) is found to be much smaller compared to the spin-orbit coupling contribution (50 cm-1). The avoided crossings between the Ω states lead to much shallower potential wells and the change of dissociation relationships of the states. The Ω-state wavefunctions are analyzed depending on their Λ-S compositions, showing the strong interactions among several quasidegenerate Λ-S states of the same total SO symmetry. The transition properties including electric dipole (E1), magnetic dipole (M1), and electric quadrupole (E2) transition moments (TMs), the Franck-Condon factors, the transition probabilities and the radiative lifetimes are computed for the transitions between Ω components of a1Δ and b1Σ+ states and ground state. The transition probabilities induced by the E1, E2, and M1 transitions are evaluated. The E2 makes little effect on transition probabilities. In contrast, the E1 transition makes the main contribution to the transition probability and the M1 transition also brings the influence that cannot be neglected. Finally, the radiative lifetimes are determined with the transition moments including E

  16. Detailed NMR, Including 1,1-ADEQUATE, and Anticancer Studies of Compounds from the Echinoderm Colobometra perspinosa

    Directory of Open Access Journals (Sweden)

    Catherine H. Liptrot

    2009-11-01

    Full Text Available From the dichloromethane/methanol extract of the crinoid Colobometra perspinosa, collected south east of Richards Island (Bedara, Family Islands, Central Great Barrier Reef, Australia, 3-(1'-hydroxypropyl-1,6,8-trihydroxy-9,10-anthraquinone [one of the two stereoisomers of rhodoptilometrin, (1], 3-propyl-1,6,8-trihydroxy-9,10-anthraquinone (3, 2-[(phenylacetylamino]ethanesulfonic acid (4, and 4-hydroxybutanoic acid (5 were isolated. Comparison of 1H- and 13C-NMR data for rhodoptilometrin (1 with those reported in the literature showed significant differences for some resonances associated with rings A and C. In an attempt to provide accurately assigned 1H- and 13C-NMR data, as well as to confirm the structure of 1, a thorough NMR investigation of this compound was undertaken. Measurements included: concentration dependent 13C, 1D selective NOE, HSQC, HMBC and 1,1-ADEQUATE. The NMR data for 4 and 5 are reported here for the first time, as is their occurrence from the marine environment. The in vitro anticancer activity of the original extract was found to be associated with 1, 3 and 5.

  17. Satisfaction rates with the current Special Type Consultation (STC) reimbursement scheme among General Practitioners – A Mixed Methods Study.

    LENUS (Irish Health Repository)

    Kiely, A

    2017-03-01

    The Special Type Consultation (STC) scheme is a fee-for-service reimbursement scheme for General Practitioners (GPs) in Ireland. Introduced in 1989, the scheme includes specified patient services involving the application of a learned skill, e.g. suturing. This study aims to establish the extent to which GPs believe this scheme is appropriate for current General Practice. This is an embedded mixed-methods study combining quantitative data on GPs working experience of and qualitative data on GPs attitudes towards the scheme. Data were collected by means of an anonymous postal questionnaire. The response rate was 60.4% (n=159.) Twenty-nine percent (n=46) disagreed and 65% (n=104) strongly disagreed that the current list of special items is satisfactory. Two overriding themes were identified: economics and advancement of the STC process. This study demonstrates an overwhelming consensus among GPs that the current STC scheme is outdated and in urgent need of revision to reflect modern General Practice.

  18. Probabilistic seismic safety assessment of a CANDU 6 nuclear power plant including ambient vibration tests: Case study

    Energy Technology Data Exchange (ETDEWEB)

    Nour, Ali [Hydro Québec, Montréal, Québec H2L4P5 (Canada); École Polytechnique de Montréal, Montréal, Québec H3C3A7 (Canada); Cherfaoui, Abdelhalim; Gocevski, Vladimir [Hydro Québec, Montréal, Québec H2L4P5 (Canada); Léger, Pierre [École Polytechnique de Montréal, Montréal, Québec H3C3A7 (Canada)

    2016-08-01

    Highlights: • In this case study, the seismic PSA methodology adopted for a CANDU 6 is presented. • Ambient vibrations testing to calibrate a 3D FEM and to reduce uncertainties is performed. • Procedure for the development of FRS for the RB considering wave incoherency effect is proposed. • Seismic fragility analysis for the RB is presented. - Abstract: Following the 2011 Fukushima Daiichi nuclear accident in Japan there is a worldwide interest in reducing uncertainties in seismic safety assessment of existing nuclear power plant (NPP). Within the scope of a Canadian refurbishment project of a CANDU 6 (NPP) put in service in 1983, structures and equipment must sustain a new seismic demand characterised by the uniform hazard spectrum (UHS) obtained from a site specific study defined for a return period of 1/10,000 years. This UHS exhibits larger spectral ordinates in the high-frequency range than those used in design. To reduce modeling uncertainties as part of a seismic probabilistic safety assessment (PSA), Hydro-Québec developed a procedure using ambient vibrations testing to calibrate a detailed 3D finite element model (FEM) of the containment and reactor building (RB). This calibrated FE model is then used for generating floor response spectra (FRS) based on ground motion time histories compatible with the UHS. Seismic fragility analyses of the reactor building (RB) and structural components are also performed in the context of a case study. Because the RB is founded on a large circular raft, it is possible to consider the effect of the seismic wave incoherency to filter out the high-frequency content, mainly above 10 Hz, using the incoherency transfer function (ITF) method. This allows reducing significantly the non-necessary conservatism in resulting FRS, an important issue for an existing NPP. The proposed case study, and related methodology using ambient vibration testing, is particularly useful to engineers involved in seismic re-evaluation of

  19. The relationship between psychosocial problems including depression and behavioural trends among middle-aged menopausal women in a cohort study.

    Science.gov (United States)

    Oi, N; Ohi, K

    2013-12-01

    We investigated the association of psychosocial problems, menopausal symptoms such as hot flushes, and trends of smoking and use of cosmetics in our previous study. In this follow-up study, we researched psychiatric disorders and psychosocial problems in menopausal women. We designed a cohort study with 577 Japanese women aged 30-64 years. Subjects were selected randomly from among women who visited the department of gender-specific medicine at Tokyo Women's Medical University East Medical Center between June 2010 and September 2011. We analysed trends such as smoking, using cosmetics, and menopausal symptoms and their association with the first lifetime episode of severe depression and anxiety using structured clinical interviews for the DSM-IV (structured clinical interview for DSM-IV, outpatient version [SCID]), the Center for Epidemiological Studies Depression Scale (CES-D) and the State-Trait Anxiety Inventory (STAI). Significant associations were observed between hot flushes, smoking and the frequency of using cosmetics. Furthermore, the trends in cosmetic use and smoking affected not only psychosocial problems, but also physical problems. Younger women suffered from psychosocial problems more than twice the rate of post-menopausal women. Those who reported their first severe depression episode were also affected by severe anxiety disorders and physical problems. By self-checking the frequency of using cosmetics is up to date knowledge of psychosocial mood problems and improving women's quality of life. © 2013 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

  20. Mineralogical and Geochemical Studies of Bone Detritus of Pleistocene Mammals, Including the Earliest in Northern Eurasia Humans

    Directory of Open Access Journals (Sweden)

    V. I. Silaev

    2015-12-01

    Full Text Available Article presents the preliminary results of mineralogical and geochemical studies of the primary and epigenetic properties of the bio-mineral and protein components in the fossil bone detritus as an example of first step of continued interdisciplinary research program. During the further implementation of this program, it is expected not only to solve a set of interrelated mineralogical, paleontological, paleoecological, paleoclimatic, and archaeological problems, but also to obtain new knowledge about the coevolution of organic, organo-mineral and inorganic substances in the geological history. The main objects of study are the fossil remains of the large Pleistocene mammals (mammoths, woolly rhinoceroses, deer, elk, horses, bison, cave and brown bear found on the territory of the Pechora Urals (62-67 ° N , South Pri-Irtyshie in Western Siberia (57-58 ° N, and Northern Taymyr (75-77 ° N. The oldest bone of Homo sapiens (Ust-Ishim human found in Northern Eurasia and remains of medieval Tobol and Irtysh Turk will be investigated as well. The results of previous studies of skin and hair of biological material from today's wild fisheries (analogues Pleistocene mammals, wild and domestic animals are considered as the reliable prerequisites for planned isotopic and geochemical studies. Use of cutting-edge research techniques will allow determining the chemical composition of bones; the elemental composition of bone collagen and bone proteins; the degree of crystallinity of bone bioapatite, and phase composition of xenomineral impurities; the isotopic composition of carbon, oxygen, and nitrogen in bioapatite and collagen; the actual molecular and crystal structure of the protein biomineral, and bone substance; the concentration of trace elements; the conditions and duration of burial and reburial of bone detritus; bone collagen bacterial degradation at an early stage of fossilization. It is expected that the implementation of the proposed project

  1. Elective breast radiotherapy including level I and II lymph nodes: A planning study with the humeral head as planning risk volume.

    Science.gov (United States)

    Surmann, Kathrin; van der Leer, Jorien; Branje, Tammy; van der Sangen, Maurice; van Lieshout, Maarten; Hurkmans, Coen W

    2017-01-18

    The aim of this study was to assess the dose to the humeral head planning risk volume with the currently used high tangential fields (HTF) and compare different planning techniques for breast radiotherapy including axillary level I and II lymph nodes (PTVn) while sparing the humeral head. Ten patients with left-sided breast cancer were enrolled in a planning study with 16 fractions of 2.66 Gy. Four planning techniques were compared: HTF, HTF with sparing of the humeral head, 6-field IMRT with sparing of the humeral head and VMAT with sparing of the humeral head. The humeral head + 10 mm was spared by restricting V40Gy HTF (V40Gy on average 20.7 cc). When sparing the humeral head in HTF, PTVn V90% decreased significantly from 97.9% to 89.4%. 6-field IMRT and VMAT had a PTVn V90% of 98.2% and 99.5% respectively. However, dose to the lungs, heart and especially the contralateral breast increased with VMAT. The humeral head is rarely spared when using HTF. When sparing the humeral head, the 6-field IMRT technique leads to adequate PTV coverage while not increasing the dose to the OARs.

  2. Angiogenesis, Proliferative Activity and DNA Ploidy in Oral Verrucous Carcinoma: A Comparative Study Including Verrucous Hyperplasia and Squamous Cell Carcinoma.

    Science.gov (United States)

    Mallick, Saumyaranjan; Breta, Monika; Gupta, Siddhartha Datta; Dinda, Amit Kumar; Mohanty, Biddhu K; Singh, Manoj K

    2015-09-01

    Verrucous carcinoma (VC) is a rare and distinct clinicopathologic variant of well-differentiated squamous cell carcinoma (SCC). This study aims to evaluate the histomorphology, proliferative activity, level of angiogenesis, and DNA ploidy of these pathological entities. This was a retrospective-prospective study of 18 cases of verrucous hyperplasia (VH), 41 cases of VC, and 44 cases of SCC. Immunohistochemical analysis for Ki-67 (MIB-1) and CD34 were performed. The tumor proliferative index, endothelial proliferative index and microvascular density were calculated. DNA ploidy was determined using image cytometry. The age range and gender ratio were similar in all three groups. The differences in MIB-1 labeling index (p = 0.0001), microvascular density (p = 0.01), and endothelial proliferative index (p = 0.001) between VC and SCC were found to be statistically significant. A non-significant increasing trend was observed in all of these parameters between VH and VC. On ploidy analysis, 100 % of SCC cases were aneuploid, compared to 39 % of VH and 86 % of VC cases. Our study demonstrates a significant difference in tumor proliferation, microvessel density, and ploidy between VC and SCC while increasing trend between VH and VC. These parameters, along with morphological findings, may be useful in differentiating these entities in small mucosal biopsies.

  3. Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study.

    Science.gov (United States)

    Andrianopoulos, Vasileios; Celli, Bartolome R; Franssen, Frits M E; Pinto-Plata, Victor M; Calverley, Peter M A; Vanfleteren, Lowie E G W; Vogiatzis, Ioannis; Vestbo, Jørgen; Agusti, Alvar; Bakke, Per S; Rennard, Stephen I; MacNee, William; Tal-Singer, Ruth; Yates, Julie C; Wouters, Emiel F M; Spruit, Martijn A

    2016-10-01

    Exercise-induced oxygen desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several clinical characteristics. 435 patients (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower exercise capacity and worse health-status (BODE, ADO indexes) compared to non-EID. Determinant of EID were obesity (BMI≥30 kg/m(2)), impaired FEV1 (≤44%pred.), moderate or worse emphysema, and low SpO2 at rest (≤93%). Linear regression indicated that each 1-point increase on the ADO-score independently elevates odds ratio (≤1.5fold) for EID. About one in five COPD patients in the ECLIPSE cohort present EID. Advanced emphysema is associated with EID. In addition, obesity, severe airflow limitation, and low resting oxygen saturation increase the risk for EID. Patients with EID in GOLD stage II have higher odds to have moderate or worse emphysema compared those with EID in GOLD stage III-IV. Emphysematous patients with high ADO-score should be monitored for EID.

  4. Neutron Scattering Studies of Liquid on or Confined in Nano- and Mesoporous Carbons, Including Carbide-Derived Carbons

    Energy Technology Data Exchange (ETDEWEB)

    Wesolowski, David J [ORNL

    2014-07-01

    This project involved the synthesis of microporous graphitic-carbon powders with subnanometer average pore size, and very narrow pore size distributions, and the use of these materials in experimental studies of pore-fluid structure and dynamics. Samples of carbide-derived carbon powder, synthesized by extraction of the metal cations from TiC by a high temperature chlorination process, followed by high temperature vacuum annealing, were prepared by Ranjan Dash and his associates at CRADA partner Y-Carbon, Inc. The resulting material had average pore sizes ranging from 5 to 8 . These powders were used in two experiments conducted by researchers involved in the Energy Frontier Research Center Directed by David J. Wesolowski at ORNL, the Fluid Interface Reactions, Structures and Transport (FIRST) Center. FIRST-funded researchers at Drexel University collaborated with scientists at the Paul Scherrer Institute, Switzerland, to measure the expansion and contraction of the microporous carbon particles during charging and discharging of supercapactor electrodes composed of these particles (Hantell et al., 2011, Electrochemistry Communications, v. 13, pp. 1221-1224.) in an electrolyte composed of tetraethylammonium tetrafluoroborate dissolved in acetonitrile. In the second experiment, researchers at Oak Ridge National Laboratory and Drexel University conducted quasielastic neutron scattering studies of the diffusional dynamics of water imbibed into the micropores of the same material (Chathoth et al., 2011, EuroPhysics Journal, v. 95, pp. 56001/1-6). These studies helped to establish the role of pores approaching the size of the solvent and dissolved ions in altering diffusional dynamics, ion transport and physical response of conducting substrates to ion desolvation and entry into subnamometer pores.

  5. Options for laser compression of matter to study dense-plasma phases at low entropy, including metallization of hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Meyer-ter-Vehn, J.; Oparin, A. [Max-Planck-Institut fuer Quantenoptik, D-85748 Garching (Germany); Aoki, T. [Tokyo Institute of Technology, 4259 Nagatsuta, Midori-Ku, Yokohama 227 (Japan)

    1996-05-01

    The potential of high-power lasers for detailed studies of strongly coupled plasmas at low entropy is discussed, emphasizing multiple-shock techniques. Some outstanding features like metallization in solids and related ionization phase transitions in the fluid phase{emdash}predicted theoretically, but not yet observed experimentally{emdash}are reviewed. Planar multiple shock compression of solid hydrogen is described, using reverberating shocks between massive liners and, alternatively, a stepped pressure pulse acting from one side. In the latter case, shock splitting and a rarefaction shock show up at the metallic phase transition. {copyright} {ital 1996 American Institute of Physics.}

  6. Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error

    OpenAIRE

    Cheng, Ching-Yu; Schache, Maria; Ikram, M. Kamran; Young, Terri L.; Guggenheim, Jeremy A.; Vitart, Veronique; MacGregor, Stuart; Verhoeven, Virginie J.M.; Barathi, Veluchamy A.; Liao, Jiemin; Hysi, Pirro G.; Bailey-Wilson, Joan E.; St. Pourcain, Beate; Kemp, John P.; McMahon, George

    2013-01-01

    Refractive errors are common eye disorders of public health importance worldwide. Ocular axial length (AL) is the major determinant of refraction and thus of myopia and hyperopia. We conducted a meta-analysis of genome-wide association studies for AL, combining 12,531 Europeans and 8,216 Asians. We identified eight genome-wide significant loci for AL (RSPO1, C3orf26, LAMA2, GJD2, ZNRF3, CD55, MIP, and ALPPL2) and confirmed one previously reported AL locus (ZC3H11B). Of the nine loci, five (LA...

  7. Reduced Dietary Sodium Intake Increases Heart Rate. A Meta-Analysis of 63 Randomized Controlled Trials Including 72 Study Populations

    DEFF Research Database (Denmark)

    Graudal, Niels A; Hubeck-Graudal, Thorbjørn; Jürgens, Gesche

    2016-01-01

    Reduced dietary sodium intake (sodium reduction) increases heart rate in some studies of animals and humans. As heart rate is independently associated with the development of heart failure and increased risk of premature death a potential increase in heart rate could be a harmful side...... increases heart rate by as much (2.4%) as it decreases blood pressure (2.5%). This side-effect, which may cause harmful health effects, contributes to the need for a revision of the present dietary guidelines....

  8. Demagnetization treatment of remanent composite microspheres studied by alternating current susceptibility measurements

    NARCIS (Netherlands)

    van Berkum, S.; Erné, B.H.

    2013-01-01

    The magnetic remanence of silica microspheres with a low concentration of embedded cobalt ferrite nanoparticles is studied after demagnetization and remagnetization treatments. When the microspheres are dispersed in a liquid, alternating current (AC) magnetic susceptibility spectra reveal a constant

  9. Adjoint sensitivity studies of loop current and eddy shedding in the Gulf of Mexico

    KAUST Repository

    Gopalakrishnan, Ganesh

    2013-07-01

    Adjoint model sensitivity analyses were applied for the loop current (LC) and its eddy shedding in the Gulf of Mexico (GoM) using the MIT general circulation model (MITgcm). The circulation in the GoM is mainly driven by the energetic LC and subsequent LC eddy separation. In order to understand which ocean regions and features control the evolution of the LC, including anticyclonic warm-core eddy shedding in the GoM, forward and adjoint sensitivities with respect to previous model state and atmospheric forcing were computed using the MITgcm and its adjoint. Since the validity of the adjoint model sensitivities depends on the capability of the forward model to simulate the real LC system and the eddy shedding processes, a 5 year (2004–2008) forward model simulation was performed for the GoM using realistic atmospheric forcing, initial, and boundary conditions. This forward model simulation was compared to satellite measurements of sea-surface height (SSH) and sea-surface temperature (SST), and observed transport variability. Despite realistic mean state, standard deviations, and LC eddy shedding period, the simulated LC extension shows less variability and more regularity than the observations. However, the model is suitable for studying the LC system and can be utilized for examining the ocean influences leading to a simple, and hopefully generic LC eddy separation in the GoM. The adjoint sensitivities of the LC show influences from the Yucatan Channel (YC) flow and Loop Current Frontal Eddy (LCFE) on both LC extension and eddy separation, as suggested by earlier work. Some of the processes that control LC extension after eddy separation differ from those controlling eddy shedding, but include YC through-flow. The sensitivity remains stable for more than 30 days and moves generally upstream, entering the Caribbean Sea. The sensitivities of the LC for SST generally remain closer to the surface and move at speeds consistent with advection by the high-speed core of

  10. Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error

    Science.gov (United States)

    Cheng, Ching-Yu; Schache, Maria; Ikram, M. Kamran; Young, Terri L.; Guggenheim, Jeremy A.; Vitart, Veronique; MacGregor, Stuart; Verhoeven, Virginie J.M.; Barathi, Veluchamy A.; Liao, Jiemin; Hysi, Pirro G.; Bailey-Wilson, Joan E.; St. Pourcain, Beate; Kemp, John P.; McMahon, George; Timpson, Nicholas J.; Evans, David M.; Montgomery, Grant W.; Mishra, Aniket; Wang, Ya Xing; Wang, Jie Jin; Rochtchina, Elena; Polasek, Ozren; Wright, Alan F.; Amin, Najaf; van Leeuwen, Elisabeth M.; Wilson, James F.; Pennell, Craig E.; van Duijn, Cornelia M.; de Jong, Paulus T.V.M.; Vingerling, Johannes R.; Zhou, Xin; Chen, Peng; Li, Ruoying; Tay, Wan-Ting; Zheng, Yingfeng; Chew, Merwyn; Rahi, Jugnoo S.; Hysi, Pirro G.; Yoshimura, Nagahisa; Yamashiro, Kenji; Miyake, Masahiro; Delcourt, Cécile; Maubaret, Cecilia; Williams, Cathy; Guggenheim, Jeremy A.; Northstone, Kate; Ring, Susan M.; Davey-Smith, George; Craig, Jamie E.; Burdon, Kathryn P.; Fogarty, Rhys D.; Iyengar, Sudha K.; Igo, Robert P.; Chew, Emily; Janmahasathian, Sarayut; Iyengar, Sudha K.; Igo, Robert P.; Chew, Emily; Janmahasathian, Sarayut; Stambolian, Dwight; Wilson, Joan E. Bailey; MacGregor, Stuart; Lu, Yi; Jonas, Jost B.; Xu, Liang; Saw, Seang-Mei; Baird, Paul N.; Rochtchina, Elena; Mitchell, Paul; Wang, Jie Jin; Jonas, Jost B.; Nangia, Vinay; Hayward, Caroline; Wright, Alan F.; Vitart, Veronique; Polasek, Ozren; Campbell, Harry; Vitart, Veronique; Rudan, Igor; Vatavuk, Zoran; Vitart, Veronique; Paterson, Andrew D.; Hosseini, S. Mohsen; Iyengar, Sudha K.; Igo, Robert P.; Fondran, Jeremy R.; Young, Terri L.; Feng, Sheng; Verhoeven, Virginie J.M.; Klaver, Caroline C.; van Duijn, Cornelia M.; Metspalu, Andres; Haller, Toomas; Mihailov, Evelin; Pärssinen, Olavi; Wedenoja, Juho; Wilson, Joan E. Bailey; Wojciechowski, Robert; Baird, Paul N.; Schache, Maria; Pfeiffer, Norbert; Höhn, René; Pang, Chi Pui; Chen, Peng; Meitinger, Thomas; Oexle, Konrad; Wegner, Aharon; Yoshimura, Nagahisa; Yamashiro, Kenji; Miyake, Masahiro; Pärssinen, Olavi; Yip, Shea Ping; Ho, Daniel W.H.; Pirastu, Mario; Murgia, Federico; Portas, Laura; Biino, Genevra; Wilson, James F.; Fleck, Brian; Vitart, Veronique; Stambolian, Dwight; Wilson, Joan E. Bailey; Hewitt, Alex W.; Ang, Wei; Verhoeven, Virginie J.M.; Klaver, Caroline C.; van Duijn, Cornelia M.; Saw, Seang-Mei; Wong, Tien-Yin; Teo, Yik-Ying; Fan, Qiao; Cheng, Ching-Yu; Zhou, Xin; Ikram, M. Kamran; Saw, Seang-Mei; Teo, Yik-Ying; Fan, Qiao; Cheng, Ching-Yu; Zhou, Xin; Ikram, M. Kamran; Saw, Seang-Mei; Wong, Tien-Yin; Teo, Yik-Ying; Fan, Qiao; Cheng, Ching-Yu; Zhou, Xin; Ikram, M. Kamran; Saw, Seang-Mei; Wong, Tien-Yin; Teo, Yik-Ying; Fan, Qiao; Cheng, Ching-Yu; Zhou, Xin; Ikram, M. Kamran; Saw, Seang-Mei; Tai, E-Shyong; Teo, Yik-Ying; Fan, Qiao; Cheng, Ching-Yu; Zhou, Xin; Ikram, M. Kamran; Saw, Seang-Mei; Teo, Yik-Ying; Fan, Qiao; Cheng, Ching-Yu; Zhou, Xin; Ikram, M. Kamran; Mackey, David A.; MacGregor, Stuart; Hammond, Christopher J.; Hysi, Pirro G.; Deangelis, Margaret M.; Morrison, Margaux; Zhou, Xiangtian; Chen, Wei; Paterson, Andrew D.; Hosseini, S. Mohsen; Mizuki, Nobuhisa; Meguro, Akira; Lehtimäki, Terho; Mäkelä, Kari-Matti; Raitakari, Olli; Kähönen, Mika; Burdon, Kathryn P.; Craig, Jamie E.; Iyengar, Sudha K.; Igo, Robert P.; Lass, Jonathan H.; Reinhart, William; Belin, Michael W.; Schultze, Robert L.; Morason, Todd; Sugar, Alan; Mian, Shahzad; Soong, Hunson Kaz; Colby, Kathryn; Jurkunas, Ula; Yee, Richard; Vital, Mark; Alfonso, Eduardo; Karp, Carol; Lee, Yunhee; Yoo, Sonia; Hammersmith, Kristin; Cohen, Elisabeth; Laibson, Peter; Rapuano, Christopher; Ayres, Brandon; Croasdale, Christopher; Caudill, James; Patel, Sanjay; Baratz, Keith; Bourne, William; Maguire, Leo; Sugar, Joel; Tu, Elmer; Djalilian, Ali; Mootha, Vinod; McCulley, James; Bowman, Wayne; Cavanaugh, H. Dwight; Verity, Steven; Verdier, David; Renucci, Ann; Oliva, Matt; Rotkis, Walter; Hardten, David R.; Fahmy, Ahmad; Brown, Marlene; Reeves, Sherman; Davis, Elizabeth A.; Lindstrom, Richard; Hauswirth, Scott; Hamilton, Stephen; Lee, W. Barry; Price, Francis; Price, Marianne; Kelly, Kathleen; Peters, Faye; Shaughnessy, Michael; Steinemann, Thomas; Dupps, B.J.; Meisler, David M.; Mifflin, Mark; Olson, Randal; Aldave, Anthony; Holland, Gary; Mondino, Bartly J.; Rosenwasser, George; Gorovoy, Mark; Dunn, Steven P.; Heidemann, David G.; Terry, Mark; Shamie, Neda; Rosenfeld, Steven I.; Suedekum, Brandon; Hwang, David; Stone, Donald; Chodosh, James; Galentine, Paul G.; Bardenstein, David; Goddard, Katrina; Chin, Hemin; Mannis, Mark; Varma, Rohit; Borecki, Ingrid; Chew, Emily Y.; Haller, Toomas; Mihailov, Evelin; Metspalu, Andres; Wedenoja, Juho; Simpson, Claire L.; Wojciechowski, Robert; Höhn, René; Mirshahi, Alireza; Zeller, Tanja; Pfeiffer, Norbert; Lackner, Karl J.; Donnelly, Peter; Barroso, Ines; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Deloukas, Panos; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S.; Mathew, Christopher G.; Palmer, Colin N.A.; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J.; Trembath, Richard C.; Viswanathan, Ananth C.; Wood, Nicholas W.; Spencer, Chris C.A.; Band, Gavin; Bellenguez, Céline; Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; Pearson, Richard; Strange, Amy; Su, Zhan; Vukcevic, Damjan; Donnelly, Peter; Langford, Cordelia; Hunt, Sarah E.; Edkins, Sarah; Gwilliam, Rhian; Blackburn, Hannah; Bumpstead, Suzannah J.; Dronov, Serge; Gillman, Matthew; Gray, Emma; Hammond, Naomi; Jayakumar, Alagurevathi; McCann, Owen T.; Liddle, Jennifer; Potter, Simon C.; Ravindrarajah, Radhi; Ricketts, Michelle; Waller, Matthew; Weston, Paul; Widaa, Sara; Whittaker, Pamela; Barroso, Ines; Deloukas, Panos; Mathew, Christopher G.; Blackwell, Jenefer M.; Brown, Matthew A.; Corvin, Aiden; Spencer, Chris C.A.; Bettecken, Thomas; Meitinger, Thomas; Oexle, Konrad; Pirastu, Mario; Portas, Laura; Nag, Abhishek; Williams, Katie M.; Yonova-Doing, Ekaterina; Klein, Ronald; Klein, Barbara E.; Hosseini, S. Mohsen; Paterson, Andrew D.; Genuth, S.; Nathan, D.M.; Zinman, B.; Crofford, O.; Crandall, J.; Reid, M.; Brown-Friday, J.; Engel, S.; Sheindlin, J.; Martinez, H.; Shamoon, H.; Engel, H.; Phillips, M.; Gubitosi-Klug, R.; Mayer, L.; Pendegast, S.; Zegarra, H.; Miller, D.; Singerman, L.; Smith-Brewer, S.; Novak, M.; Quin, J.; Dahms, W.; Genuth, Saul; Palmert, M.; Brillon, D.; Lackaye, M.E.; Kiss, S.; Chan, R.; Reppucci, V.; Lee, T.; Heinemann, M.; Whitehouse, F.; Kruger, D.; Jones, J.K.; McLellan, M.; Carey, J.D.; Angus, E.; Thomas, A.; Galprin, A.; Bergenstal, R.; Johnson, M.; Spencer, M.; Morgan, K.; Etzwiler, D.; Kendall, D.; Aiello, Lloyd Paul; Golden, E.; Jacobson, A.; Beaser, R.; Ganda, O.; Hamdy, O.; Wolpert, H.; Sharuk, G.; Arrigg, P.; Schlossman, D.; Rosenzwieg, J.; Rand, L.; Nathan, D.M.; Larkin, M.; Ong, M.; Godine, J.; Cagliero, E.; Lou, P.; Folino, K.; Fritz, S.; Crowell, S.; Hansen, K.; Gauthier-Kelly, C.; Service, J.; Ziegler, G.; Luttrell, L.; Caulder, S.; Lopes-Virella, M.; Colwell, J.; Soule, J.; Fernandes, J.; Hermayer, K.; Kwon, S.; Brabham, M.; Blevins, A.; Parker, J.; Lee, D.; Patel, N.; Pittman, C.; Lindsey, P.; Bracey, M.; Lee, K.; Nutaitis, M.; Farr, A.; Elsing, S.; Thompson, T.; Selby, J.; Lyons, T.; Yacoub-Wasef, S.; Szpiech, M.; Wood, D.; Mayfield, R.; Molitch, M.; Schaefer, B.; Jampol, L.; Lyon, A.; Gill, M.; Strugula, Z.; Kaminski, L.; Mirza, R.; Simjanoski, E.; Ryan, D.; Kolterman, O.; Lorenzi, G.; Goldbaum, M.; Sivitz, W.; Bayless, M.; Counts, D.; Johnsonbaugh, S.; Hebdon, M.; Salemi, P.; Liss, R.; Donner, T.; Gordon, J.; Hemady, R.; Kowarski, A.; Ostrowski, D.; Steidl, S.; Jones, B.; Herman, W.H.; Martin, C.L.; Pop-Busui, R.; Sarma, A.; Albers, J.; Feldman, E.; Kim, K.; Elner, S.; Comer, G.; Gardner, T.; Hackel, R.; Prusak, R.; Goings, L.; Smith, A.; Gothrup, J.; Titus, P.; Lee, J.; Brandle, M.; Prosser, L.; Greene, D.A.; Stevens, M.J.; Vine, A.K.; Bantle, J.; Wimmergren, N.; Cochrane, A.; Olsen, T.; Steuer, E.; Rath, P.; Rogness, B.; Hainsworth, D.; Goldstein, D.; Hitt, S.; Giangiacomo, J.; Schade, D.S.; Canady, J.L.; Chapin, J.E.; Ketai, L.H.; Braunstein, C.S.; Bourne, P.A.; Schwartz, S.; Brucker, A.; Maschak-Carey, B.J.; Baker, L.; Orchard, T.; Silvers, N.; Ryan, C.; Songer, T.; Doft, B.; Olson, S.; Bergren, R.L.; Lobes, L.; Rath, P. Paczan; Becker, D.; Rubinstein, D.; Conrad, P.W.; Yalamanchi, S.; Drash, A.; Morrison, A.; Bernal, M.L.; Vaccaro-Kish, J.; Malone, J.; Pavan, P.R.; Grove, N.; Iyer, M.N.; Burrows, A.F.; Tanaka, E.A.; Gstalder, R.; Dagogo-Jack, S.; Wigley, C.; Ricks, H.; Kitabchi, A.; Murphy, M.B.; Moser, S.; Meyer, D.; Iannacone, A.; Chaum, E.; Yoser, S.; Bryer-Ash, M.; Schussler, S.; Lambeth, H.; Raskin, P.; Strowig, S.; Zinman, B.; Barnie, A.; Devenyi, R.; Mandelcorn, M.; Brent, M.; Rogers, S.; Gordon, A.; Palmer, J.; Catton, S.; Brunzell, J.; Wessells, H.; de Boer, I.H.; Hokanson, J.; Purnell, J.; Ginsberg, J.; Kinyoun, J.; Deeb, S.; Weiss, M.; Meekins, G.; Distad, J.; Van Ottingham, L.; Dupre, J.; Harth, J.; Nicolle, D.; Driscoll, M.; Mahon, J.; Canny, C.; May, M.; Lipps, J.; Agarwal, A.; Adkins, T.; Survant, L.; Pate, R.L.; Munn, G.E.; Lorenz, R.; Feman, S.; White, N.; Levandoski, L.; Boniuk, I.; Grand, G.; Thomas, M.; Joseph, D.D.; Blinder, K.; Shah, G.; Boniuk; Burgess; Santiago, J.; Tamborlane, W.; Gatcomb, P.; Stoessel, K.; Taylor, K.; Goldstein, J.; Novella, S.; Mojibian, H.; Cornfeld, D.; Lima, J.; Bluemke, D.; Turkbey, E.; van der Geest, R.J.; Liu, C.; Malayeri, A.; Jain, A.; Miao, C.; Chahal, H.; Jarboe, R.; Maynard, J.; Gubitosi-Klug, R.; Quin, J.; Gaston, P.; Palmert, M.; Trail, R.; Dahms, W.; Lachin, J.; Cleary, P.; Backlund, J.; Sun, W.; Braffett, B.; Klumpp, K.; Chan, K.; Diminick, L.; Rosenberg, D.; Petty, B.; Determan, A.; Kenny, D.; Rutledge, B.; Younes, Naji; Dews, L.; Hawkins, M.; Cowie, C.; Fradkin, J.; Siebert, C.; Eastman, R.; Danis, R.; Gangaputra, S.; Neill, S.; Davis, M.; Hubbard, L.; Wabers, H.; Burger, M.; Dingledine, J.; Gama, V.; Sussman, R.; Steffes, M.; Bucksa, J.; Nowicki, M.; Chavers, B.; O’Leary, D.; Polak, J.; Harrington, A.; Funk, L.; Crow, R.; Gloeb, B.; Thomas, S.; O’Donnell, C.; Soliman, E.; Zhang, Z.M.; Prineas, R.; Campbell, C.; Ryan, C.; Sandstrom, D.; Williams, T.; Geckle, M.; Cupelli, E.; Thoma, F.; Burzuk, B.; Woodfill, T.; Low, P.; Sommer, C.; Nickander, K.; Budoff, M.; Detrano, R.; Wong, N.; Fox, M.; Kim, L.; Oudiz, R.; Weir, G.; Espeland, M.; Manolio, T.; Rand, L.; Singer, D.; Stern, M.; Boulton, A.E.; Clark, C.; D’Agostino, R.; Lopes-Virella, M.; Garvey, W.T.; Lyons, T.J.; Jenkins, A.; Virella, G.; Jaffa, A.; Carter, Rickey; Lackland, D.; Brabham, M.; McGee, D.; Zheng, D.; Mayfield, R.K.; Boright, A.; Bull, S.; Sun, L.; Scherer, S.; Zinman, B.; Natarajan, R.; Miao, F.; Zhang, L.; Chen;, Z.; Nathan, D.M.; Makela, Kari-Matti; Lehtimaki, Terho; Kahonen, Mika; Raitakari, Olli; Yoshimura, Nagahisa; Matsuda, Fumihiko; Chen, Li Jia; Pang, Chi Pui; Yip, Shea Ping; Yap, Maurice K.H.; Meguro, Akira; Mizuki, Nobuhisa; Inoko, Hidetoshi; Foster, Paul J.; Zhao, Jing Hua; Vithana, Eranga; Tai, E-Shyong; Fan, Qiao; Xu, Liang; Campbell, Harry; Fleck, Brian; Rudan, Igor; Aung, Tin; Hofman, Albert; Uitterlinden, André G.; Bencic, Goran; Khor, Chiea-Chuen; Forward, Hannah; Pärssinen, Olavi; Mitchell, Paul; Rivadeneira, Fernando; Hewitt, Alex W.; Williams, Cathy; Oostra, Ben A.; Teo, Yik-Ying; Hammond, Christopher J.; Stambolian, Dwight; Mackey, David A.; Klaver, Caroline C.W.; Wong, Tien-Yin; Saw, Seang-Mei; Baird, Paul N.

    2013-01-01

    Refractive errors are common eye disorders of public health importance worldwide. Ocular axial length (AL) is the major determinant of refraction and thus of myopia and hyperopia. We conducted a meta-analysis of genome-wide association studies for AL, combining 12,531 Europeans and 8,216 Asians. We identified eight genome-wide significant loci for AL (RSPO1, C3orf26, LAMA2, GJD2, ZNRF3, CD55, MIP, and ALPPL2) and confirmed one previously reported AL locus (ZC3H11B). Of the nine loci, five (LAMA2, GJD2, CD55, ALPPL2, and ZC3H11B) were associated with refraction in 18 independent cohorts (n = 23,591). Differential gene expression was observed for these loci in minus-lens-induced myopia mouse experiments and human ocular tissues. Two of the AL genes, RSPO1 and ZNRF3, are involved in Wnt signaling, a pathway playing a major role in the regulation of eyeball size. This study provides evidence of shared genes between AL and refraction, but importantly also suggests that these traits may have unique pathways. PMID:24144296

  11. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.

    Science.gov (United States)

    Cheng, Ching-Yu; Schache, Maria; Ikram, M Kamran; Young, Terri L; Guggenheim, Jeremy A; Vitart, Veronique; MacGregor, Stuart; Verhoeven, Virginie J M; Barathi, Veluchamy A; Liao, Jiemin; Hysi, Pirro G; Bailey-Wilson, Joan E; St Pourcain, Beate; Kemp, John P; McMahon, George; Timpson, Nicholas J; Evans, David M; Montgomery, Grant W; Mishra, Aniket; Wang, Ya Xing; Wang, Jie Jin; Rochtchina, Elena; Polasek, Ozren; Wright, Alan F; Amin, Najaf; van Leeuwen, Elisabeth M; Wilson, James F; Pennell, Craig E; van Duijn, Cornelia M; de Jong, Paulus T V M; Vingerling, Johannes R; Zhou, Xin; Chen, Peng; Li, Ruoying; Tay, Wan-Ting; Zheng, Yingfeng; Chew, Merwyn; Burdon, Kathryn P; Craig, Jamie E; Iyengar, Sudha K; Igo, Robert P; Lass, Jonathan H; Chew, Emily Y; Haller, Toomas; Mihailov, Evelin; Metspalu, Andres; Wedenoja, Juho; Simpson, Claire L; Wojciechowski, Robert; Höhn, René; Mirshahi, Alireza; Zeller, Tanja; Pfeiffer, Norbert; Lackner, Karl J; Bettecken, Thomas; Meitinger, Thomas; Oexle, Konrad; Pirastu, Mario; Portas, Laura; Nag, Abhishek; Williams, Katie M; Yonova-Doing, Ekaterina; Klein, Ronald; Klein, Barbara E; Hosseini, S Mohsen; Paterson, Andrew D; Makela, Kari-Matti; Lehtimaki, Terho; Kahonen, Mika; Raitakari, Olli; Yoshimura, Nagahisa; Matsuda, Fumihiko; Chen, Li Jia; Pang, Chi Pui; Yip, Shea Ping; Yap, Maurice K H; Meguro, Akira; Mizuki, Nobuhisa; Inoko, Hidetoshi; Foster, Paul J; Zhao, Jing Hua; Vithana, Eranga; Tai, E-Shyong; Fan, Qiao; Xu, Liang; Campbell, Harry; Fleck, Brian; Rudan, Igor; Aung, Tin; Hofman, Albert; Uitterlinden, André G; Bencic, Goran; Khor, Chiea-Chuen; Forward, Hannah; Pärssinen, Olavi; Mitchell, Paul; Rivadeneira, Fernando; Hewitt, Alex W; Williams, Cathy; Oostra, Ben A; Teo, Yik-Ying; Hammond, Christopher J; Stambolian, Dwight; Mackey, David A; Klaver, Caroline C W; Wong, Tien-Yin; Saw, Seang-Mei; Baird, Paul N

    2013-08-08

    Refractive errors are common eye disorders of public health importance worldwide. Ocular axial length (AL) is the major determinant of refraction and thus of myopia and hyperopia. We conducted a meta-analysis of genome-wide association studies for AL, combining 12,531 Europeans and 8,216 Asians. We identified eight genome-wide significant loci for AL (RSPO1, C3orf26, LAMA2, GJD2, ZNRF3, CD55, MIP, and ALPPL2) and confirmed one previously reported AL locus (ZC3H11B). Of the nine loci, five (LAMA2, GJD2, CD55, ALPPL2, and ZC3H11B) were associated with refraction in 18 independent cohorts (n = 23,591). Differential gene expression was observed for these loci in minus-lens-induced myopia mouse experiments and human ocular tissues. Two of the AL genes, RSPO1 and ZNRF3, are involved in Wnt signaling, a pathway playing a major role in the regulation of eyeball size. This study provides evidence of shared genes between AL and refraction, but importantly also suggests that these traits may have unique pathways. Copyright © 2013 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  12. Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia

    Science.gov (United States)

    Eghtedar, Alireza; Verstovsek, Srdan; Estrov, Zeev; Burger, Jan; Cortes, Jorge; Bivins, Carol; Faderl, Stefan; Ferrajoli, Alessandra; Borthakur, Gautam; George, Solly; Scherle, Peggy A.; Newton, Robert C.; Kantarjian, Hagop M.

    2012-01-01

    We conducted a phase 2 study of ruxolitinib in patients with relapsed/refractory leukemias. Patients with acceptable performance status (0-2), adequate organ function, and no active infection, received ruxolitinib 25 mg orally twice a day for 4 weeks (1 cycle). Response was assessed after every 2 cycles of treatment, and patients who completed 2 cycles were allowed to continue treatment until disease progression. Dose escalation to 50 mg twice daily was permitted in patients demonstrating a benefit. Thirty-eight patients, with a median age of 69 years (range, 45-88), were treated. The median number of prior therapies was 2 (range, 1-6). Twelve patients had JAK2V617F mutation. Patients received a median of 2 cycles of therapy (range, 1-22). Three of 18 patients with postmyeloproliferative neoplasm (MPN) acute myeloid leukemia (AML) showed a significant response; 2 achieved complete remission (CR) and one achieved a CR with insufficient recovery of blood counts (CRi). The responding patients with palpable spleens also had significant reductions in spleen size. Overall, ruxolitinib was very well tolerated with only 4 patients having grade 3 or higher toxicity. Ruxolitinib has modest antileukemic activity as a single agent, particularly in patients with post-MPN AML. The study was registered at www.clinicaltrials.gov as NCT00674479. PMID:22422826

  13. Social exclusion predicts impaired self-regulation: a 2-year longitudinal panel study including the transition from preschool to school.

    Science.gov (United States)

    Stenseng, Frode; Belsky, Jay; Skalicka, Vera; Wichstrøm, Lars

    2015-04-01

    The need-to-belong theory stipulates that social exclusion (i.e., being rejected by peers) impairs the ability to self-regulate, and experimental studies with adults support this contention, at least on a short-term basis. Few studies have investigated whether social exclusion affects the development of self-regulation of children in a more enduring manner. By using data from a community sample of 762 children, we investigated reciprocal relations between social exclusion and self-regulation from age 4 to age 6. Social exclusion was reported by teachers, whereas self-regulation was reported by parents. Autoregressive latent cross-lagged analyses showed that social exclusion predicted impaired development of dispositional self-regulation and, reciprocally, that poor self-regulation predicted enhanced social exclusion. In other words, social exclusion undermines children's development of self-regulation, whereas poor self-regulation increases the likelihood of exclusion. Results illuminate the applied relevance of the need-to-belong theory.

  14. Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia.

    Science.gov (United States)

    Eghtedar, Alireza; Verstovsek, Srdan; Estrov, Zeev; Burger, Jan; Cortes, Jorge; Bivins, Carol; Faderl, Stefan; Ferrajoli, Alessandra; Borthakur, Gautam; George, Solly; Scherle, Peggy A; Newton, Robert C; Kantarjian, Hagop M; Ravandi, Farhad

    2012-05-17

    We conducted a phase 2 study of ruxolitinib in patients with relapsed/refractory leukemias. Patients with acceptable performance status (0-2), adequate organ function, and no active infection, received ruxolitinib 25 mg orally twice a day for 4 weeks (1 cycle). Response was assessed after every 2 cycles of treatment, and patients who completed 2 cycles were allowed to continue treatment until disease progression. Dose escalation to 50 mg twice daily was permitted in patients demonstrating a benefit. Thirty-eight patients, with a median age of 69 years (range, 45-88), were treated. The median number of prior therapies was 2 (range, 1-6). Twelve patients had JAK2V617F mutation. Patients received a median of 2 cycles of therapy (range, 1-22). Three of 18 patients with postmyeloproliferative neoplasm (MPN) acute myeloid leukemia (AML) showed a significant response; 2 achieved complete remission (CR) and one achieved a CR with insufficient recovery of blood counts (CRi). The responding patients with palpable spleens also had significant reductions in spleen size. Overall, ruxolitinib was very well tolerated with only 4 patients having grade 3 or higher toxicity. Ruxolitinib has modest antileukemic activity as a single agent, particularly in patients with post-MPN AML. The study was registered at www.clinicaltrials.gov as NCT00674479.

  15. Technical Note: Monte Carlo study of (106) Ru/(106) Rh ophthalmic plaques including the (106) Rh gamma spectrum.

    Science.gov (United States)

    Hermida-López, Marcelino; Brualla, Lorenzo

    2017-06-01

    To assess the influence of the (106) Rh gamma spectrum on the Monte Carlo simulation of (106) Ru/(106) Rh ophthalmic plaques, which has been neglected without a quantitative estimation in all previous publications. Simulations were run with the penelope 2014 Monte Carlo code for radiation transport. Depth-dose distributions in water were simulated for the plaque models CCA, CCC, CCX and CIA. In addition to the (106) Rh beta spectrum, all gamma components from the (106) Rh gamma spectrum were included in the simulations. Depth-dose curves were compared with those obtained without considering the (106) Rh gamma spectrum. Moreover, half-value (HVL) and tenth-value layers (TVL) were estimated for the (106) Rh gamma spectrum in water, PMMA, stainless steel and lead. Some practical radiation protection applications were discussed. Parallel computing was implemented to reduce computing time. The contribution of the (106) Rh gamma spectrum on the depth-dose curves is negligible at depths of clinical interest. The HVL and TVL of the (106) Rh gamma spectrum were found to be similar to those of (137) Cs. The air-kerma rate at 1 m for a CCA plaque in typical clinical conditions was about 0.4μGym2h-1, resulting in equivalent doses at that point elow 0.05 mSv during a treatment. The air-kerma rate would be underestimated by a factor of 5 if the (106) Rh gamma spectrum were not considered. Also, a freely available software tool was developed to ease parallelization of penelope 2014 simulations that use penmain as steering main program. The influence of the (106) Rh gamma spectrum is not relevant for clinical purposes, thus validating the common assumption from the literature. However, for simulations at large distances from the plaques, such as for radiation shielding assessment and estimation of dose to personnel, the gamma spectrum from (106) Rh must be taken into account to obtain accurate results. © 2017 American Association of Physicists in Medicine.

  16. A review of the currently recognised zoogonid cercariae, including the identification and emergence ecology of Cercaria capricornia XI (Digenea: Zoogonidae) from Nassarius olivaceus (Gastropoda: Nassariidae) in Central Queensland, Australia.

    Science.gov (United States)

    Barnett, Leonie J; Miller, Terrence L; Cribb, Thomas H

    2014-08-01

    In the present study, we review the known zoogonid cercariae, summarise their life-cycles and first intermediate host distributions, and present a new cercaria, Cercaria capricornia XI (Digenea: Zoogonidae), which was found in one of three nassariid gastropods, Nassarius olivaceus (Bruguière), surveyed in the intertidal zone in the Capricornia region of Central Queensland, Australia. Morphological data and molecular analysis of the ITS2 rDNA region support placement of this cercaria in the family Zoogonidae but do not allow any further resolution of its identity. There are now fifteen cercariae described as belonging to the Zoogonidae; thirteen of these, including the present species, infect neogastropods as first intermediate hosts and two use vetigastropods. This study reinforces the pattern that the Nassariidae is by far the most commonly reported family for the Zoogonidae. Given its richness we predict that the Nassariidae will prove to harbour many more zoogonid species.

  17. NUMERICAL STUDY ON THE FORMATION OF THE SOUTH CHINA SEA WARM CURRENT I. BAROTROPIC CASE

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In this work, Princeton Ocean Model (POM) was used to study the formation of the South China Sea Warm Current (SCSWC) in the barotropic case. Monthly averaged wind stress and the inflow/outflow transports in January were used in the numerical simulation which reproduced the SCSWC. The effects of wind stress and inflow/outflow were studied separately. Numerical experiments showed that the Kuroshio intrusion through the Luzon Strait and the slope shelf in the northern SCS are necessary conditions for the formation of the SCSWC. In a flat bottom topography experiment, the wind stress driven northeast current in the northern SCS is a compensatory current.

  18. A status analysis of current digital marketing: a case study of Kauneusstudio FAB

    OpenAIRE

    Tran, Trong

    2015-01-01

    The subject of this thesis is a small company's current digital marketing status. This study was con-ducted in order for the owners of the beauty and hair salon Kauneusstudio FAB to improve their understanding of their customers’ behavior online and the significance of each digital channel they are using in the present marketing strategy. The goal of this study is to provide information for the company to recognize the strengths and the development points of the current digital marketing stra...

  19. Numerical study on short-circuit current of single layer organic solar cells with Schottkey contacts

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The influence of the cathode work function,carriers mobilities and temperature on the short-circuit current of single layer organic solar cells with Schottkey contacts was numerically studied,and the quantitative dependences of the short-circuit current on these quantities were obtained.The results provide the theoretical foundation for experimental study of single layer organic solar cells with Schottkey contacts.

  20. Synchronous Study of Ferroresonance and Inrush Current Phenomena and their Related Reasons in Ground Power Networks

    Science.gov (United States)

    Akrami, Amin; Ghaderi, Mohammad; Ghadi, Saeed

    2010-01-01

    Energizing the power transformers usually results in flowing very high inrush currents. This harmful current can be minimized using controlled switching and considering the value of residual flux. But nowadays, developing the ground power networks results in high increment of ferroresonance phenomenon occurrence due to the line' capacitance reactance and nonlinear inductive reactance of power transformer's core. In this study, these transient phenomena and their cause have studied synchronously.

  1. Characteristics of the Aragonitic Layer in Adult Oyster Shells, Crassostrea gigas: Structural Study of Myostracum including the Adductor Muscle Scar

    Directory of Open Access Journals (Sweden)

    Seung-Woo Lee

    2011-01-01

    Full Text Available Myostracum, which is connected from the umbo to the edge of a scar, is not a single layer composed of prismatic layers, but a hierarchically complex multilayered shape composed of minerals and an organic matrix. Through the analysis of the secondary structure, the results revealed that a β-antiparallel structure was predominant in the mineral phase interface between the myostracum (aragonite and bottom folia (calcite. After the complete decalcification and deproteinization, the membrane obtained from the interface between the myostracum buried in upper folia, and the bottom folia was identified as chitin. The transitional zone in the interface between the adductor muscle scar and folia are verified. The myostracum disappeared at the edge of the scar of the posterior side. From this study, the entire structure of the myostracum from the adult oyster shell of Crassostrea gigas could be proposed.

  2. Polyphasic taxonomic study of the genera Gordona and Tsukamurella including the description of Tsukamurella wratislaviensis sp. nov.

    Science.gov (United States)

    Goodfellow, M; Zakrzewska-Czerwinska, J; Thomas, E G; Mordarski, M; Ward, A C; James, A L

    1991-06-01

    Representatives of the genera Gordona and Tsukamurella together with related actinomycetes were the subject of chemotaxonomic, numerical taxonomic and DNA homology studies. In the numerical analysis the organisms were examined for 116 unit characters and the data sorted using the simple matching, Jaccard and pattern coefficients; clustering was achieved using the unweighted pair group method with arithmetic averages algorithm. The numerical groupings were not affected by the statistics used or by test error, estimated at 1.9%. The numerical taxonomic data supported the integrity of the four validly described species of Gordona but indicated that the genus Tsukamurella might encompass a species in addition to Tsukamurella paurometabola. The putative new strains had chemical, enzymic, nutritional and tolerance properties consistent with their assignment to the genus Tsukamurella and formed a DNA homology group corresponding to the one formed by the Tsukamurella paurometabola strains. It is proposed that the new taxon be assigned to the genus Tsukamurella as Tsukamurella wratislaviensis.

  3. Global Studies of the Sulfur Cycle Including the Influence of DMS and Fossil Fuel Sulfur on Climate and Climate Change

    Science.gov (United States)

    Penner, Joyce E.

    1998-01-01

    The indirect effect of anthropogenic aerosols, wherein aerosol particles are thought to increase cloud droplet concentrations and cloud lifetime, is the most uncertain component of climate forcing over the past 100 years. Here, for the first time, we use a mechanistic treatment of droplet nucleation and a prognostic treatment of the number of cloud droplets to study the indirect aerosol effect from changes in carbonaceous and sulfate aerosols. Cloud droplet nucleation is parameterized as a function of total aerosol number concentration, updraft velocity and a shape parameter, which takes into account the mechanism, of sulfate aerosol formation, while cloud droplet number depends on the nucleation as well as on droplet sinks. Whereas previous treatments have predicted annual average indirect effects between -1 and -2 W/sq m, we obtain an indirect aerosol effect between -0.14 W/sq m and -0.42 W/sq m in the global mean.

  4. Theoretical studies on NLO properties of push-pull multi-cycle electro-optical polymer intermediates including thiophene ring

    Institute of Scientific and Technical Information of China (English)

    付伟; 封继康; 于坤千; 任爱民; 王江洪; 沈玉全

    2000-01-01

    The second-order nonlinear optical susceptiblities βuk, βμ and third-order non-linear optical susceptibilities γijkl, (γ〉 of a series of the novel push-pull multi-ring eletro- photo polymer intermediates have been calculated. The influences of molecular structure, donor, acceptor and the frequency of external field onβandγ, and the relationship betweenγand the number of thiophene rings ( i. e. conjugated chain length) have been studied using INDO/SCI methods combined with sum-over-state(SOS) formula. The calculated results show that γ is proportional to 2.69 power of the chain length of the conjugated molecular bonds when the length is not quite long.

  5. A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides.

    Science.gov (United States)

    Stohs, Sidney J; Miller, Mark J S

    2014-01-01

    A case study is reported whereby an individual with known sulfite and sulfonamide allergies develops hypersensitivity to taurine above a threshold level as well as to the non-nutritive sweetener acesulfame potassium, compounds that are not normally associated with allergic reactions. Sulfites, sulfonamides, taurine and acesulfame potassium all contain a SO3 moiety. Challenge tests provide evidence for the hypersensitivities to taurine and acesulfame potassium. The subject is also allergic to thiuram mix and thimerosal, sulfur containing compounds, as well as to various food products. This may be the first case where hypersensitivities to taurine and acesulfame potassium have been documented and reported. Several mechanistic explanations are provided for the untoward reactions to taurine and acesulfame potassium. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

  6. Including the urban heat island in spatial heat health risk assessment strategies: a case study for Birmingham, UK

    Directory of Open Access Journals (Sweden)

    Thornes John E

    2011-06-01

    Full Text Available Abstract Background Heatwaves present a significant health risk and the hazard is likely to escalate with the increased future temperatures presently predicted by climate change models. The impact of heatwaves is often felt strongest in towns and cities where populations are concentrated and where the climate is often unintentionally modified to produce an urban heat island effect; where urban areas can be significantly warmer than surrounding rural areas. The purpose of this interdisciplinary study is to integrate remotely sensed urban heat island data alongside commercial social segmentation data via a spatial risk assessment methodology in order to highlight potential heat health risk areas and build the foundations for a climate change risk assessment. This paper uses the city of Birmingham, UK as a case study area. Results When looking at vulnerable sections of the population, the analysis identifies a concentration of "very high" risk areas within the city centre, and a number of pockets of "high risk" areas scattered throughout the conurbation. Further analysis looks at household level data which yields a complicated picture with a considerable range of vulnerabilities at a neighbourhood scale. Conclusions The results illustrate that a concentration of "very high" risk people live within the urban heat island, and this should be taken into account by urban planners and city centre environmental managers when considering climate change adaptation strategies or heatwave alert schemes. The methodology has been designed to be transparent and to make use of powerful and readily available datasets so that it can be easily replicated in other urban areas.

  7. Study of Leakage Current Behaviour on Artificially Polluted Surface of Ceramic Insulator

    Institute of Scientific and Technical Information of China (English)

    B. Subba Reddy; G. R. Nagabhushana

    2003-01-01

    This paper presents the results of the study concerning to the leakage current be-haviour on artificially polluted ceramic insulator surface. From the present study it was observedthat there is a reasonably well-defined inception of current i.e. scintillations at a finite voltage.The corresponding voltages for extinction of the current are in the range of 0.8 kV to 2.1 kV.Obviously, the dry band formed in the immediate vicinity of the pin prevents smooth current flowas the voltage rises from zero. Only when the voltage is adequate it causes a flashover of the dryband and current starts flowing. As is common in similar current extinction phenomena, herealso, the extinction voltages are significantly lower than the inception voltages.Further, the voltage-current curves invariably show hysteresis - the leakage currents are lowerin the reducing portion of the voltage. This is obviously due to drying of the wet pollutantlayer thereby increasing its resistance. It is believed that this is the first time that such a directquantitative evidence of drying in individual half cycles is experimentally visualized.

  8. Assessment of BSBA Students' Conversancy in Current Business Issues: A Case Study

    Science.gov (United States)

    Hogan, Eileen A.; Maskulka, Therese A.; Kaminski, Kathleen A.

    2014-01-01

    In 2008, the faculty of the College of Business at Kutztown University developed a set of five learning goals for its BSBA program. In fall, 2011, the college's Assurance of Learning Committee began to pursue the assessment of the last of these goals: "BSBA graduates will be conversant in current business issues, including ethics, social…

  9. Rural-urban migration including formal and informal workers in the urban sector: an agent-based numerical simulation study

    Science.gov (United States)

    Branco, Nilton; Oliveira, Tharnier; Silveira, Jaylson

    2012-02-01

    The goal of this work is to study rural-urban migration in the early stages of industrialization. We use an agent-based model and take into account the existence of informal and formal workers on the urban sector and possible migration movements, dependent on the agents' social and private utilities. Our agents are place on vertices of a square lattice, such that each vertex has only one agent. Rural, urban informal and urban formal workers are represented by different states of a three-state Ising model. At every step, a fraction a of the agents may change sectors or migrate. The total utility of a given agent is then calculated and compared to a random utility, in order to check if this agent turns into an actual migrant or changes sector. The dynamics is carried out until an equilibrium state is reached and equilibrium variables are then calculated and compared to available data. We find that a generalized Harris-Todaro condition is satisfied [1] on these equilibrium regimes, i.e, the ratio between expected wages between any pair of sectors reach a constant value. [4pt] [1] J. J. Silveira, A. L. Esp'indola and T. J. Penna, Physica A, 364, 445 (2006).

  10. CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.

    Science.gov (United States)

    Zalewski, B; Famulski, W; Sulkowska, M; Sobaniec-Lotowska, M; Piotrowski, Z; Kisielewski, W; Sulkowski, S

    2001-01-01

    CD44 is a cell adhesion molecule involved in tumour growth and progression. This study was undertaken to evaluate the expression of CD44 standard protein in a series of 54 colorectal adenocarcinomas in correlation with cathepsin D immunoreactivity and some other clinicopathological variables. Formalin-fixed and paraffin-embedded tissues were investigated with anti-CD44 standard protein and anti-cathepsin D antibody. Immunolocalisation of CD44 protein and cathepsin D was performed using LSAB method. 13 (41.9%) out of 31 carcinomas without lymph-node metastases had positive CD44 expression, whereas only 6 (26.1%) out of 23 carcinomas with lymph-node metastases were found positive for CD44 expression. CD44 expression in carcinomas was positively correlated with tumour cells cathepsin D (p<0.01) immunostaining. statistically significant correlation was found between the expression of CD44 standard protein and the tumour site, age and sex of the patients. These results suggest that the standard-type CD44 protein lymph-node metastases, probably with cooperation of cathepsin D.

  11. Spectroscopic Studies of Extremly Metal-Poor Stars with Subaru/HDS:II.The r-process Elements, Including Thorium

    CERN Document Server

    Honda, S; Kajino, T; Ando, H; Beers, T C; Izumiura, H; Sadakane, K; Takada-Hidai, M

    2004-01-01

    We present the abundance analyses for the neutron-capture elements, and discuss the observed abundance distributions in very metal-poor stars with excesses of r-process elements. As has been found by previous abundance studies, the star-to-star scatter in the abundances of neutron-capture elements are very large. The abundance patterns of the heavy neutron-capture elements (56 $\\leq$ Z $\\leq$ 70) in seven objects with moderate to large excesses of the neutron-capture elements are similar to that of the solar system r-process component. These results strongly suggest that the heavy neutron-capture elements in these objects are primarily synthesized by the r-process. On the other hand, the abundance ratios of the light neutron-capture elements (38 $\\leq$ Z $\\leq$ 46) exhibit a rather large dispersion. Our inspection of the correlation between Sr and Ba abundances in very metal-poor stars reveals that the dispersion of the Sr abundances clearly decreases with increasing Ba abundance. This results support previou...

  12. Cold antibody autoimmune hemolytic anemia and lymphoproliferative disorders: a retrospective study of 20 patients including clinical, hematological, and molecular findings.

    Science.gov (United States)

    Arthold, Cathrin; Skrabs, Cathrin; Mitterbauer-Hohendanner, Gerlinde; Thalhammer, Renate; Simonitsch-Klupp, Ingrid; Panzer, Simon; Valent, Peter; Lechner, Klaus; Jäger, Ulrich; Sillaber, Christian

    2014-06-01

    A total of 20 patients with cold antibody hemolytic anemia were evaluated in a retrospective study of them, 15 had a monoclonal gammopathy of unknown significance (MGUS): 14 with MGUS of immunoglobulin M (IgM) subtype and 1 with immunoglobulin G subtype. One patient had smoldering Waldenström's macroglobulinemia, but four patients had no monoclonal protein and no evidence of lymphoma. However, in three of these patients, we were able to demonstrate a (mono-)clonal rearrangement of their immunoglobulin heavy and/or light chains. Of the 20 patients, 5 had IgHV34 nucleotide sequence indicating that the antibody was directed against the "I" antigen. Two patients exhibited a progressive increase of IgM over time, however without increasing hemolytic activity. Moreover, in two patients with long-term follow-up, we were able to correlate recurrent hemolytic activity with low environmental temperatures. Among four patients treated with rituximab, all four responded to treatment. However, treatment effect was only transient in all of them.

  13. How useful is the DSM-5 severity indicator in bulimia nervosa? A clinical study including a measure of impairment.

    Science.gov (United States)

    Jenkins, Paul E; Luck, Amy; Cardy, Jessica; Staniford, Jessica

    2016-12-30

    The severity criterion used in DSM-5 for bulimia nervosa (BN) was investigated in 214 individuals referred for treatment at a regional eating disorders service in the UK. In addition to comparing eating disorder symptoms, impairment secondary to these symptoms was also assessed. According to guidance in DSM-5, 94 individuals were classified as mild (43.9%), 70 as moderate (32.7%), 32 as severe (15.0%), and 8 as extreme (3.7%) levels of BN severity. Due to small numbers in the latter two groups, it was necessary to combine these to form one 'severe/extreme' group. Analyses on these three groups suggested no group effect on demographic variables but differences were seen on measures of eating pathology, psychological distress, and psychosocial impairment between the mild group and other groups. Individuals in the moderate and severe/extreme groups scored comparably on most measures of pathology and impairment. The results are broadly consistent with past studies on community samples although together question the demarcation between moderate and more severe groups of individuals with BN. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  14. Tennessee Valley region study: potential year 2000 radiological dose to population resulting from nuclear facility operations. [Includes glossary

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-06-01

    A companion report, DOE/ET-0064/1, presents a geographic, cultural, and demographic profile of the Tennessee Valley Region study area. This report describes the calculations of radionuclide release and transport and of the resultant dose to the regional population, assuming a projected installed capacity of 220,000 MW in the year 2000, of which 144,000 MW would be nuclear. All elements of the fuel cycle were assumed to be in operation. The radiological dose was calculated as a one-year dose based on ingestion of 35 different food types as well as for nine non-food pathways, and was reported as dose to the total body and for six specific organs for each of four age groups (infant, child, teen, and adult). Results indicate that the average individual would receive an incremental dose of 7 x 10/sup -4/ millirems in the year 2000 from the operation of nuclear facilities within and adjacent to the region, five orders of magnitude smaller than the dose from naturally occurring radiation in the area. The major contributor to dose was found to be tritium, and the most significant pathways were immersion in air, inhalation of air, transpiration of tritium (absorption through the skin), and exposure radionuclide-containing soil. 60 references.

  15. Bipole-dipole interpretation with three-dimensional models (including a field study of Las Alturas, New Mexico)

    Energy Technology Data Exchange (ETDEWEB)

    Hohmann, G.W.; Jiracek, G.R.

    1979-09-01

    The bipole-dipole responses of three-dimensional (3D) prisms were studied using an integral equation numerical solution. Although response patterns are quite complex, the bipole-dipole method appears to be a useful, efficient means of mapping the areal distribution of resistivity. However, 3D modeling is required for quantitative interpretation. Computer time for our solution varies from negligible for small bodies to 6 minutes on a UNIVAC 1108 for the largest possible body (85 cubes). Bipole-dipole response varies significantly with bipole orientation and position, but simply changing the distance between the bipole and the body does not greatly affect the response. However, the response is complex and interpretation ambiguous if both transmitter electrodes are located directly over a body. Boundaries of shallow bodies are much better resolved than those of deep bodies. Conductive bodies produce false polarization highs that can confuse interpretation. It is difficult to distinguish the effects of depth and resistivity contrast, and, as with all electrical methods, depth extent is difficult to resolve. Interactive interpretation of bipole-dipole field results from a geothermal prospect in New Mexico illustrates the value of the 3D modeling technique.

  16. Radioreceptor assay to study the affinity of benzodiazepines and their receptor binding activity in human plasma including their active metabolites

    Energy Technology Data Exchange (ETDEWEB)

    Dorow, R.G.; Seidler, J.; Schneider, H.H. (Schering A.G., Berlin (Germany, F.R.))

    1982-04-01

    A radioreceptor assay has been established to measure the receptor affinities of numerous benzodiazepines in clinical use. The time course of receptor binding activity was studied by this method in the plasma of eight healthy subjects randomly treated with 1mg lormetazepam (Noctamid(R)), 2mg flunitrazepam (Rohypnol(R)), and 10mg diazepam (Valium(R)), and placebo on a cross-over basis. Blood samples were collected up to 154h after treatment. Receptor affinities of numerous benzodiazepines in vitro show good correlation with therapeutic human doses (r=0.96) and may be predictive of drug potency in man. Mean peak plasma levels of lormetazepam binding equivalents were 4.8+-1 ng/ml at 2h after lormetazepam, 7.2+-1.8 ng/ml at 8h after flunitrazepam, and 17.9+-2.7 ng/ml at 15h after diazepam. Plasma elimination halflives of benzodiazepine binding equivalents were 9.3, 23 and 63h, respectively. Slow elimination of benzodiazepine binding equivalents following flunitrazepam and diazepam may be due to persistent active metabolites.

  17. PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors.

    Science.gov (United States)

    Maleszewski, Joseph J; Larsen, Brandon T; Kip, Nefize Sertac; Castonguay, Mathieu C; Edwards, William D; Carney, J Aidan; Kipp, Benjamin R

    2014-08-01

    Cardiac myxoma usually occurs as a solitary mass, but occasionally develops as part of a familial syndrome, the Carney complex (CNC). Two thirds of CNC-associated cardiac myxomas exhibit mutations in PRKAR1A. PRKAR1A mutations occur in both familial and sporadic forms of CNC but have not been described in isolated (nonsyndromic) cardiac myxomas. A total of 127 consecutive cardiac myxomas surgically resected at Mayo Clinic (1993 to 2011) from 110 individuals were studied. Clinical, radiologic, and pathologic findings were reviewed. Of these, 103 patients had isolated cardiac myxomas, and 7 patients had the tumor as a component of CNC. Age and sex distributions were different for CNC (mean 26 y, range 14 to 44 y, 71% female) and non-CNC (mean 62 y, range 18 to 92 y, 63% female) patients. PRKAR1A immunohistochemical analysis (IHC) was performed, and myxoma cell reactivity was graded semiquantitatively. Bidirectional Sanger sequencing was performed in 3 CNC patients and 29 non-CNC patients, to test for the presence of mutations in all coding regions and intron/exon boundaries of the PRKAR1A gene. IHC staining showed that all 7 CNC cases lacked PRKAR1A antigenicity and that 33 (32%) isolated cardiac myxomas were similarly nonreactive. Of tumors subjected to sequencing analysis, 2 (67%) CNC myxomas and 9 (31%) non-CNC myxomas had pathogenic PRKAR1A mutations. No germline mutations were found in 4 non-CNC cases tested. PRKAR1A appears to play a role in the development of both syndromic and nonsyndromic cardiac myxomas. Routine IHC evaluation of cardiac myxomas for PRKAR1A expression may be useful in excluding a diagnosis of CNC.

  18. Experimental study on directional solidification of Al-Si alloys under the influence of electric currents

    Science.gov (United States)

    Räbiger, D.; Zhang, Y.; Galindo, V.; Franke, S.; Willers, B.; Eckert, S.

    2016-07-01

    The application of electric currents during solidification can cause grain refinement in metallic alloys. However, the knowledge about the mechanisms underlying the decrease in grain size remains fragmentary. This study considers the solidification of Al-Si alloys under the influence of electric currents for the configuration of two parallel electrodes at the free surface. Solidification experiments were performed under the influence of both direct currents (DC) and rectangular electric current pulses (ECP). The interaction between the applied current and its own induced magnetic field causes a Lorentz force which produces an electro-vortex flow. Numerical simulations were conducted to calculate the Lorentz force, the Joule heating and the induced melt flow. The numerical predictions were confirmed by isothermal flow measurements in eutectic GaInSn. The results demonstrate that the grain refining effect observed in our experiments can be ascribed solely to the forced melt flow driven by the Lorentz force.

  19. Alternating current cloud point extraction on a microchip: a comprehensive study.

    Science.gov (United States)

    Sasaki, Naoki; Takemura, Azusa; Sato, Kae

    2012-11-01

    We present a comprehensive study of alternating current cloud point extraction (ACPE) on a microchip. ACPE is an extraction technique for preconcentration of membrane-associated biomolecules. To characterize and optimize ACPE, we carried out ACPE experiments under various experimental conditions including amplitude and frequency of applied voltages, flow velocity, and concentration of surfactant, analyte, and salt. We found that ACPE has an amplitude threshold (15 V(p-p)), above which the extraction was more efficient. The dependence of the extraction on frequency (>5 MHz) was insignificant. Efficient extraction was achieved when the velocity of the test solution was 0.10∼0.67 mm s⁻¹ and the concentration of surfactant was 0.10∼1.0%. In contrast, the extraction was independent of the concentration of analytes (0.20∼20 μmol dm⁻³). The technique was applicable to solutions with a salt concentration of 0.050∼0.15 mol dm⁻³ under temperature control of the devices. Solution temperature in ACPE was also studied. These results provide guidelines for use of the ACPE technique in microfluidic chemical and biochemical analyses.

  20. Predictive study of the poloidal field coil insert behaviour under pulsed current tests

    Science.gov (United States)

    Lacroix, B.; Ciazynski, D.; Duchateau, J. L.; Nicollet, S.; Pauty, N.

    2008-02-01

    Within the ITER Poloidal Field conductor design validation, the Poloidal Field Conductor Insert (PFCI) has been manufactured and will be tested in the Central Solenoid Model Coil (CSMC) facility at JAEA Naka (Japan). In this test facility, the PFCI can be tested under ITER-relevant operating conditions, the field produced by the CSMC being varied to simulate the real situation of the PF coils in ITER. Predictive analyses have been performed in order to study the electromagnetic and thermal-hydraulic behaviour of the PFCI, under two scenarios proposed for pulsed current tests. During these scenarios, simulations have been performed with the THEA code, in which classical formulas for the AC losses in a cable have been introduced. The study focuses on the lower part of the winding, which is a 44 m long conductor including a joint. It covers the sample thermal-hydraulic behaviour with particular emphasis on the losses. Due to the overcompaction in the joint area, the total energy dissipated during a scenario can be equivalent in the joint and in the conductor, in spite of the reduced length of the joint (0.45 m). This particular point is discussed and has led to the analysis of the temperature margin in the joint.

  1. Multiday Transcranial Direct Current Stimulation Causes Clinically Insignificant Changes in Childhood Dystonia: A Pilot Study.

    Science.gov (United States)

    Bhanpuri, Nasir H; Bertucco, Matteo; Young, Scott J; Lee, Annie A; Sanger, Terence D

    2015-10-01

    Abnormal motor cortex activity is common in dystonia. Cathodal transcranial direct current stimulation may alter cortical activity by decreasing excitability while anodal stimulation may increase motor learning. Previous results showed that a single session of cathodal transcranial direct current stimulation can improve symptoms in childhood dystonia. Here we performed a 5-day, sham-controlled, double-blind, crossover study, where we measured tracking and muscle overflow in a myocontrol-based task. We applied cathodal and anodal transcranial direct current stimulation (2 mA, 9 minutes per day). For cathodal transcranial direct current stimulation (7 participants), 3 subjects showed improvements whereas 2 showed worsening in overflow or tracking error. The effect size was small (about 1% of maximum voluntary contraction) and not clinically meaningful. For anodal transcranial direct current stimulation (6 participants), none showed improvement, whereas 5 showed worsening. Thus, multiday cathodal transcranial direct current stimulation reduced symptoms in some children but not to a clinically meaningful extent, whereas anodal transcranial direct current stimulation worsened symptoms. Our results do not support transcranial direct current stimulation as clinically viable for treating childhood dystonia.

  2. Electric field characteristics of electroconvulsive therapy with individualized current amplitude: a preclinical study.

    Science.gov (United States)

    Lee, Won Hee; Lisanby, Sarah H; Laine, Andrew F; Peterchev, Angel V

    2013-01-01

    This study examines the characteristics of the electric field induced in the brain by electroconvulsive therapy (ECT) with individualized current amplitude. The electric field induced by bilateral (BL), bifrontal (BF), right unilateral (RUL), and frontomedial (FM) ECT electrode configurations was computed in anatomically realistic finite element models of four nonhuman primates (NHPs). We generated maps of the electric field strength relative to an empirical neural activation threshold, and determined the stimulation strength and focality at fixed current amplitude and at individualized current amplitudes corresponding to seizure threshold (ST) measured in the anesthetized NHPs. The results show less variation in brain volume stimulated above threshold with individualized current amplitudes (16-36%) compared to fixed current amplitude (30-62%). Further, the stimulated brain volume at amplitude-titrated ST is substantially lower than that for ECT with conventional fixed current amplitudes. Thus individualizing the ECT stimulus current could compensate for individual anatomical variability and result in more focal and uniform electric field exposure across different subjects compared to the standard clinical practice of using high, fixed current for all patients.

  3. Coupled Numerical Study of Turbidity Currents, Internal Hydraulic Jump and Morphological Signatures

    Science.gov (United States)

    Hu, P.; Cao, Z.; He, Z.; Gareth, P.

    2013-12-01

    Abstract: The last two decades have seen intensive experimental and numerical studies of the occurrence condition of internal hydraulic jump in turbidity currents and the induced morphological signatures (Garcia and Parker 1989; Kostic and Parker 2006). Yet there are two critical issues that remain insufficiently or inappropriately addressed. First, depositional turbidity currents are imposed on steep slopes in both flume experiments and numerical cases, exclusively based on a configuration consisting of an upstream sloping portion and a downstream horizontal portion linked by a slope break. This appears physically counterintuitive as steep slope should favour self-accelerating erosional turbidity currents (Parker et al. 1986). The second issue concerns the numerical studies. There exist significant interactions among the current, sediment transport and bed topography. Due to the slope break in bed, the current may experience an internal hydraulic jump, leaving morphological signatures on the bed, which in turn affects the current evolution. Nevertheless, simplified decoupled models are exclusively employed in previous numerical investigations, in which the interactions are either partly or completely ignored without sufficient justification. The present paper aims to address the above-mentioned two issues relevant to the occurrence condition of the internal hydraulic jump and the induced morphological signatures. A recently developed well-balanced coupled numerical model for turbidity currents (Hu et al. 2012) is applied. In contrast to previous studies, erosional turbidity currents will be imposed at the upstream boundary, which is much more typical of the field. The effects of sediment size, bed slope decrease, and upstream and downstream boundary conditions are revealed in detail. In addition, the evolution of turbidity currents over a bed characterized by gradual decrease in slope is also discussed. References Garcia, M. H., and Parker, G. (1989). Experiments

  4. Langmuir probe study in the nonresonant current drive regime of helicon discharge

    Indian Academy of Sciences (India)

    Manash Kumar Paul; Dhiraj Bora

    2008-07-01

    Characterization of the current drive regime is done for helicon wave-generated plasma in a torus, at a very high operating frequency. A radiofrequency-compensated Langmuir probe is designed and used for the measurement of plasma parameters along with the electron energy distributions in radial scans of the plasma. The electron energy distribution patterns obtained in the operational regime suggest that Landau damping cannot be responsible for the efficient helicon discharge in the present study. A typical peaked radial density profile, high plasma temperature and absence of an appreciable amount of energetic electrons for resonant wave–particle interactions, suggest that the chosen operational regime is suitable for the study of nonresonant current drive by helicon wave. Successful and significant current drive achieved in our device clearly demonstrates the capability of nonresonant current drive by helicon waves in the present operational regime.

  5. Study on Catastrophic Air Current Early-warning and Control System of Coalmines

    Directory of Open Access Journals (Sweden)

    L.F. Fang

    2016-02-01

    Full Text Available Catastrophic air current significantly influences the stability of ventilation system, and existing studies have not considered the flow characteristics of catastrophic air current when designing the control systems. To analyze the effects of different kinds of coalmine accidents on safety production, grey relation entropy theory was used to analyze the hazard assessment of coalmine accidents. Fluent software was employed to study the flow characteristics of catastrophic air current, and the catastrophic air current early-warning and control system of coalmine was researched according to the theoretical analysis and numerical simulation. The threat of fire accidents and roof accidents were larger than other accidents. The influence of temperature and CO volume fraction distribution of fire accidents to the tailwind side was larger than that of the weather side, and gradient decreased on the weather side. This system can effectively control the spread of fire and poisonous gas,

  6. Factors influencing the current practice of self-medication consultations in Eastern Indonesian community pharmacies: a qualitative study.

    Science.gov (United States)

    Brata, Cecilia; Fisher, Colleen; Marjadi, Brahmaputra; Schneider, Carl R; Clifford, Rhonda M

    2016-05-13

    Research has shown that the current practice of pharmacy staff when providing self-medication consultations in Indonesia is suboptimal. To improve the performance of pharmacy staff when providing self-medication consultations in community pharmacies, the factors that influence current practice need to be understood. The aim of this study is to identify the factors that influence current practice of pharmacy staff when handling self-medication consultations in Eastern Indonesian community pharmacies. Fifteen in-depth interviews were conducted with pharmacists, pharmacy technicians, pharmacy owners, and counter attendants. Thematic analysis was used to generate findings. The current practice of pharmacy staff when handling self-medication consultations is directly influenced by the professionalism of pharmacy staff and patient responses to the consultations. These factors are in turn affected by the organisational context of the pharmacy and the external pharmacy environment. The organisational context of the pharmacy includes staffing, staff affordability, and the availability of time and facilities in which to provide consultations. The external pharmacy environment includes the number of trained pharmacy staff in the research setting, the relevance of pharmacy education to the needs of pharmacy practice, the support offered by the Indonesian Pharmacists Association, a competitive business environment, and the policy environment. Complex and inter-related factors influence the current practice of pharmacy staff when providing self-medication consultations in community pharmacies in this research setting. Multiple strategies will be required to improve consultation practices.

  7. Experimental study on bed-load sediment transport under irregular wave and current combined flow

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Using an irregularly oscillating tray and flume, a series of experiments are completed to evaluate bed-load sediment transport rate under irregular wave- current coexistent fild. Testing conditions include three interaction angles 0°, 45°, 90° and two kinds of median sizes (0.38 and 1.10 mm).The results of transport rate show that the net sediment transport rate can be expressed approximately as the function of the maximum bottom shear stress of waves, mean shear stress of current and the grain size.

  8. Theoretical study of the source-drain current and gate leakage current to understand the graphene field-effect transistors.

    Science.gov (United States)

    Yu, Cui; Liu, Hongmei; Ni, Wenbin; Gao, Nengyue; Zhao, Jianwei; Zhang, Haoli

    2011-02-28

    We designed acene molecules attached to two semi-infinite metallic electrodes to explore the source-drain current of graphene and the gate leakage current of the gate dielectric material in the field-effect transistors (FETs) device using the first-principles density functional theory combined with the non-equilibrium Green's function formalism. In the acene-based molecular junctions, we modify the connection position of the thiol group at one side, forming different electron transport routes. The electron transport routes besides the shortest one are defined as the cross channels. The simulation results indicate that electron transport through the cross channels is as efficient as that through the shortest one, since the conductance is weakly dependent on the distance. Thus, it is possible to connect the graphene with multiple leads, leading the graphene as a channel utilized in the graphene-based FETs in the mesoscopic system. When the conjugation of the cross channel is blocked, the junction conductance decreases dramatically. The differential conductance of the BA-1 is nearly 7 (54.57 μS) times as large as that of the BA-4 (7.35 μS) at zero bias. Therefore, the blocked graphene can be employed as the gate dielectric material in the top-gated graphene FET device, since the leakage current is small. The graphene-based field-effect transistors fabricated with a single layer of graphene as the channel and the blocked graphene as the gate dielectric material represent one way to overcome the problem of miniaturization which faces the new generation of transistors.

  9. Theory including future not excluded

    DEFF Research Database (Denmark)

    Nagao, K.; Nielsen, H.B.

    2013-01-01

    We study a complex action theory (CAT) whose path runs over not only past but also future. We show that, if we regard a matrix element defined in terms of the future state at time T and the past state at time TA as an expectation value in the CAT, then we are allowed to have the Heisenberg equation......, Ehrenfest's theorem, and the conserved probability current density. In addition,we showthat the expectation value at the present time t of a future-included theory for large T - t and large t - T corresponds to that of a future-not-included theory with a proper inner product for large t - T. Hence, the CAT...

  10. Comparison of a 'freeze-all' strategy including GnRH agonist trigger versus a 'fresh transfer' strategy including hCG trigger in assisted reproductive technology (ART): a study protocol for a randomised controlled trial.

    Science.gov (United States)

    Stormlund, Sacha; Løssl, Kristine; Zedeler, Anne; Bogstad, Jeanette; Prætorius, Lisbeth; Nielsen, Henriette Svarre; Bungum, Mona; Skouby, Sven O; Mikkelsen, Anne Lis; Andersen, Anders Nyboe; Bergh, Christina; Humaidan, Peter; Pinborg, Anja

    2017-07-31

    Pregnancy rates after frozen embryo transfer (FET) have improved in recent years and are now approaching or even exceeding those obtained after fresh embryo transfer. This is partly due to improved laboratory techniques, but may also be caused by a more physiological hormonal and endometrial environment in FET cycles. Furthermore, the risk of ovarian hyperstimulation syndrome is practically eliminated in segmentation cycles followed by FET and the use of natural cycles in FETs may be beneficial for the postimplantational conditions of fetal development. However, a freeze-all strategy is not yet implemented as standard care due to limitations of large randomised trials showing a benefit of such a strategy. Thus, there is a need to test the concept against standard care in a randomised controlled design. This study aims to compare ongoing pregnancy and live birth rates between a freeze-all strategy with gonadotropin-releasing hormone (GnRH) agonist triggering versus human chorionic gonadotropin (hCG) trigger and fresh embryo transfer in a multicentre randomised controlled trial. Multicentre randomised, controlled, double-blinded trial of women undergoing assisted reproductive technology treatment including 424 normo-ovulatory women aged 18-39 years from Denmark and Sweden. Participants will be randomised (1:1) to either (1) GnRH agonist trigger and single vitrified-warmed blastocyst transfer in a subsequent hCG triggered natural menstrual cycle or (2) hCG trigger and single blastocyst transfer in the fresh (stimulated) cycle. The primary endpoint is to compare ongoing pregnancy rates per randomised patient in the two treatment groups after the first single blastocyst transfer. The study will be performed in accordance with the ethical principles in the Helsinki Declaration. The study is approved by the Scientific Ethical Committees in Denmark and Sweden. The results of the study will be publically disseminated. NCT02746562; Pre-results. © Article author(s) (or their

  11. Safety and feasibility of transcranial direct current stimulation in pediatric hemiparesis: randomized controlled preliminary study.

    Science.gov (United States)

    Gillick, Bernadette T; Feyma, Tim; Menk, Jeremiah; Usset, Michelle; Vaith, Amy; Wood, Teddi Jean; Worthington, Rebecca; Krach, Linda E

    2015-03-01

    Transcranial direct current stimulation (tDCS) is a form of noninvasive brain stimulation that has shown improved adult stroke outcomes. Applying tDCS in children with congenital hemiparesis has not yet been explored. The primary objective of this study was to explore the safety and feasibility of single-session tDCS through an adverse events profile and symptom assessment within a double-blind, randomized placebo-controlled preliminary study in children with congenital hemiparesis. A secondary objective was to assess the stability of hand and cognitive function. A double-blind, randomized placebo-controlled pretest/posttest/follow-up study was conducted. The study was conducted in a university pediatric research laboratory. Thirteen children, ages 7 to 18 years, with congenital hemiparesis participated. Adverse events/safety assessment and hand function were measured. Participants were randomly assigned to either an intervention group or a control group, with safety and functional assessments at pretest, at posttest on the same day, and at a 1-week follow-up session. An intervention of 10 minutes of 0.7 mA tDCS was applied to bilateral primary motor cortices. The tDCS intervention was considered safe if there was no individual decline of 25% or group decline of 2 standard deviations for motor evoked potentials (MEPs) and behavioral data and no report of adverse events. No major adverse events were found, including no seizures. Two participants did not complete the study due to lack of MEP and discomfort. For the 11 participants who completed the study, group differences in MEPs and behavioral data did not exceed 2 standard deviations in those who received the tDCS (n=5) and those in the control group (n=6). The study was completed without the need for stopping per medical monitor and biostatisticial analysis. A limitation of the study was the small sample size, with data available for 11 participants. Based on the results of this study, tDCS appears to be safe

  12. Experimental and Numerical Study of Wave-Induced Long-Shore Currents on A Mild Slope Beach

    Institute of Scientific and Technical Information of China (English)

    SUN Tao; TAO Jian-hua

    2005-01-01

    The long-shore current distribution on a mild slope beach is studied by combining the numerical model and the physical experiment. The experiments of long-shore currents under the action of regular and irregular waves are conducted on mild beaches with different slopes in a wave basin. A numerical model is established, which includes a wave propagation model, a wave breaking model and a long-shore current model. The validity of the numerical model is proved by the comparison of its results with the results of the experimental model. It is concluded that the wave-induced long-shore current is influenced significantly by the incident wave height, the wave angle and the beach slope. Its application to the Bohai Bay indicates that the wave-induced currents have the same order of magnitude as the tide currents in the near-shore zone of mill slope beach. In the design of wastewater outfall locations on a mild-slope beach with shallow water of the Bohai Bay, the position of the outfall should be 10 km away from the shoreline, which is outside of the surf-zone.

  13. [The current structure of rheumatology in German universities. The Rhesus and RISA-II studies].

    Science.gov (United States)

    Keyszer, G; Burmester, G-R

    2008-11-01

    The teaching of rheumatology requires competent rheumatological structures in German university hospitals. In 2002, the nationwide 'RISA' survey on the extent and quality of rheumatological training in Germany brought a variety of deficits to light. In the same year, a new law regulating the licensing process to practise medicine came into force. Since this law aimed at a more practise-based training of medical students, hopes were high that the conditions for the rheumatological education of students would improve over time. Therefore, our survey was repeated four years later, supplemented by a questionnaire covering scientific activities in rheumatology at university hospitals. In addition, another survey, known as the Rhesus study, was started in 2007 to analyse the size and capacity of rheumatological departments and units at German medical faculties. The results show that rheumatology represents one of the smallest subjects of internal medicine in Germany. Several German university hospitals do not include a rheumatological department at all. Since 2002, no significant progress has been made with regard to the extent of training for medical students in rheumatology, and the new licensing law has not yet shown beneficial effects in this respect. The current data represent only a snap-shot. The development of rheumatology requires cautious observation to prevent this important area of medicine from being sacrificed to economic interests or structural changes.

  14. Current Trends in the Studies of Allelochemicals for Their Application in Practice

    Directory of Open Access Journals (Sweden)

    Arsen V.Viter

    2015-06-01

    Full Text Available The allelochemicals have been largely used in agriculture, forestry, landscape design and ornamental plant growing for many decades. However, there is a lack of the comprehensive studies, where existing publications are analyzed and synthesized with regards to the theoretic aspects for such usage. The objective of this paper was to systemize the advances in the research on allelochemicals’ application in practice. Numerous novel methodological propositions have risen recently. We classified them into the physical, chemical, biological, biotechnological and cropgrowing approaches. The allelochemicals consist of the wide diversity of the substances according to their chemical nature. Among these substances we outlined, firstly, the unidentified plant exudates and the products of green manuring, secondly, the chemically characterized or purified substances, which include alcohols, organic acids, aliphatic compounds, aromatic, alicyclic and nitrogen-contain organic compounds. Several groups of the biotic sources of allelochemicals were described: dicotyledonous and monocotyledonous plants, particularly under their colonization by non-pathogenic strains of Fusarium oxysporum, marine flora and fungi, which exhibit the herbicidal activity. Different targets of the allelochemical application were listed in the paper and they were categorized into several groups: higher flora, animals, unicellular and multi-cellular fungi. We concluded that there is lack of the modern multifaceted knowledge bases for the information about the allelochemical application. Those knowledge bases must be useful in order to choose the appropriate biological method for solving each particular problem of plant cultivation. To that end we systemized the results of current investigation about the usage of allelochemicals in practice.

  15. Comparison of Galvanic Currents Generated Between Different Combinations of Orthodontic Brackets and Archwires Using Potentiostat: An In Vitro Study.

    Science.gov (United States)

    Nayak, Rabindra S; Shafiuddin, Bareera; Pasha, Azam; Vinay, K; Narayan, Anjali; Shetty, Smitha V

    2015-07-01

    Technological advances in wire selection and bracket design have led to improved treatment efficiency and allowed longer time intervals between appliance adjustments. The wires remain in the mouth for a longer duration and are subjected to electrochemical reactions, mechanical forces of mastication and generalized wear. These cause different types of corrosion. This study was done to compare the galvanic currents generated between different combinations of brackets and archwires commonly used in orthodontic practices. The materials used for the study included different commercially available orthodontic archwires and brackets. The galvanic current generated by individual materials and different combinations of these materials was tested and compared. The orthodontic archwires used were 0.019″ × 0.025″ heat-activated nickel-titanium (3M Unitek), 0.019″ × 0.025″ beta-titanium (3M Unitek) and 0.019″ × 0.025″ stainless steel (3M Unitek). The orthodontic brackets used were 0.022″ MBT laser-cut (Victory Series, 3M Unitek) and metal-injection molded (Leone Company) maxillary central incisor brackets respectively. The ligature wire used for ligation was 0.009″ stainless steel ligature (HP Company). The galvanic current for individual archwires, brackets, and the different bracket-archwire-ligature combinations was measured by using a Potentiostat machine. The data were generated using the Linear Sweep Voltammetry and OriginPro 8.5 Graphing and Data Analysis Softwares. The study was conducted in two phases. Phase I comprised of five groups for open circuit potential (OCP) and galvanic current (I), whereas Phase II comprised of six groups for galvanic current alone. Mean, standard deviation and range were computed for the OCP and galvanic current (I) values obtained. Results were subjected to statistical analysis through ANOVA. In Phase I, higher mean OCP was recorded in stainless steel archwire, followed by beta-titanium archwire, heat-activated nickel

  16. Prenatal recruitment of participants for a birth cohort study including cord blood collection: results of a feasibility study in Bremen, Germany

    Directory of Open Access Journals (Sweden)

    Ernst, Sinja Alexandra

    2015-04-01

    their primary care gynecologist or later on in hospital by the attending obstetricians or project staff.Results: Of the 22 invited primary care gynecologists requested to enroll pregnant women for the study, 8 gynecologists actually collaborated. A total of 200 eligible women were invited to participate in the study, 48 (24% of whom agreed. 34 women were enrolled by primary care gynecologists, with one gynecologist enrolling 26 women. Twelve of recruited via hospitals were enrolled by study staff. A total of 41 women consented to the collection of umbilical cord blood and maternal blood samples, and samples could be stored for 54% of them. Reason for non-participation were the uncertainty whether or not the full study would be conducted and the fact that the participants were not willing to decide for their children whether or not genetic information (cord blood can be stored for research purposes.Conclusion: Enrolling parents in a birth cohort study that includes biosampling is a challenge, but participation can be improved through close collaboration with primary care gynecologists and maternity hospitals. Cord blood collection may impede participation, especially when maternity hospitals offer an alternative option for cord blood donation.

  17. Current State of Clinical Studies on Diagnosis and Treatment of Sudden Deafness in China

    Institute of Scientific and Technical Information of China (English)

    YU Yaping; YANG Shiming; GUO Wei; YANG Weiyan; GU Rui

    2006-01-01

    Objective To evaluate the current status of clinical studies on diagnosis and treatment of sudden deafness (SD) in China by retrospective reviewing articles on SD published in Chinese journals in the past 5 years.Special attention is given to whether the diagnosis and treatment standards established in 1996 by the otolaryngology branch of Chinese Medical Association (the"1996 standard") were followed. Methods The terms of "Sudden deafness" and "treatment" were used as the keywords in searching articles published between 2000 and 2004 in the Chinese biomedicine literature database and Chinese journal network. Principles of evidence-based medicine were applied in reviewing the articles. Results Two hundreds and thirty- four articles were identified, including 176 between 2000 and 2002 and 58 between 2003 and 2004. Among the 176 articles published between 2000 and 2002,effects of medications were studies in 126 articles, of which only 26 (20.6%) followed the"1996 standards".Eighty-nine (70.6%) were reported based on controlled clinical trials (CCT) and 36 (28.5%) met the criteria of randomized controlled trails (RCT). Of the 58 articles published between 2003 and 2004, drug effects were evaluated in 25 articles, which were all based on the "1996 standards". However, there lacked placebo control, follow-up data or statistical analysis in these papers. Only 6 articles reported side-effects from pharmacological treatment. Conclusions While a significant number of articles on SD were published in the past 5 years, the "1996 standards" were followed only in a small number of them. The standards may not be appropriate in guiding research and need to be modified for improved guidance to SD management. Multi-center, RCTs should be a crucial part in studies on SD.

  18. Ocean Science for Decision-Making: Current Activities of the National Research Council's Ocean Studies Board

    Science.gov (United States)

    Roberts, S.; Glickson, D.; Mengelt, C.; Forrest, S.; Waddell, K.

    2012-12-01

    The National Research Council is a private, nonprofit organization chartered by Congress in 1916 as an expansion of the U.S. National Academy of Sciences. Its mission is to improve the use of science in government decision making and public policy, increase public understanding, and promote the acquisition and dissemination of knowledge in matters involving science, engineering, technology, and health. Within the National Research Council, the Ocean Studies Board (OSB) mission is to explore the science, policies, and infrastructure needed to understand, manage, and conserve coastal and marine environments and resources. OSB undertakes studies and workshops on emerging scientific and policy issues at the request of federal agencies, Congress, and others; provides program reviews and guidance; and facilitates communication on oceanographic issues among different sectors. OSB also serves as the U.S. National Committee to the international, nongovernmental Scientific Committee on Oceanic Research (SCOR). OSB has produced reports on a wide range of topics of interest to researchers and educators, the federal government, the non-profit sector, and industry. Recent reports have focused on ecosystem services in the Gulf of Mexico after the Deepwater Horizon oil spill, sea level rise on the U.S. west coast, scientific ocean drilling needs and accomplishments, requirements for sustained ocean color measurements, critical infrastructure for ocean research, tsunami warning and preparedness, ocean acidification, and marine and hydrokinetic power resource assessments. Studies that are currently underway include responding to oil spills in the Arctic, evaluating the effectiveness of fishery stock rebuilding plans, and reviewing the National Ocean Acidification Research Plan. OSB plays an important role in helping create policy decisions and disseminating important information regarding various aspects of ocean science.

  19. Bowker, L. et al., eds. Unity in diversity? current trends in translation studies. Bowker, L. et al., eds. Unity in diversity? current trends in translation studies.

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Vasconcellos

    2008-04-01

    Full Text Available Unity in Diversity? Current Trends in Translation Studies—a result of the diverse range of phenomena addressed in the Dublin City University Translation Studies (TS Conference (1996—proves to be a timely publication of St. Jerome Publishing at the end of the 20th century. This collection of papers exploring the central and uptodate issue of disciplinary identity in the young academic field of TS is in tune with the present concern in the area, as can be seen in the topic suggested for the international Translation Conference I IATIS Conference:“Disciplinary Identity—Redefining Translation in the 21st Century” (cf. www.iatis.org/content/korea/programme.php, to be held in 2005. Unity in Diversity? Current Trends in Translation Studies—a result of the diverse range of phenomena addressed in the Dublin City University Translation Studies (TS Conference (1996—proves to be a timely publication of St. Jerome Publishing at the end of the 20th century. This collection of papers exploring the central and uptodate issue of disciplinary identity in the young academic field of TS is in tune with the present concern in the area, as can be seen in the topic suggested for the international Translation Conference I IATIS Conference:“Disciplinary Identity—Redefining Translation in the 21st Century” (cf. www.iatis.org/content/korea/programme.php, to be held in 2005.

  20. Cranial electrotherapy stimulation and transcranial pulsed current stimulation: a computer based high-resolution modeling study.

    Science.gov (United States)

    Datta, Abhishek; Dmochowski, Jacek P; Guleyupoglu, Berkan; Bikson, Marom; Fregni, Felipe

    2013-01-15

    The field of non-invasive brain stimulation has developed significantly over the last two decades. Though two techniques of noninvasive brain stimulation--transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)--are becoming established tools for research in neuroscience and for some clinical applications, related techniques that also show some promising clinical results have not been developed at the same pace. One of these related techniques is cranial electrotherapy stimulation (CES), a class of transcranial pulsed current stimulation (tPCS). In order to understand further the mechanisms of CES, we aimed to model CES using a magnetic resonance imaging (MRI)-derived finite element head model including cortical and also subcortical structures. Cortical electric field (current density) peak intensities and distributions were analyzed. We evaluated different electrode configurations of CES including in-ear and over-ear montages. Our results confirm that significant amounts of current pass the skull and reach cortical and subcortical structures. In addition, depending on the montage, induced currents at subcortical areas, such as midbrain, pons, thalamus and hypothalamus are of similar magnitude than that of cortical areas. Incremental variations of electrode position on the head surface also influence which cortical regions are modulated. The high-resolution modeling predictions suggest that details of electrode montage influence current flow through superficial and deep structures. Finally we present laptop based methods for tPCS dose design using dominant frequency and spherical models. These modeling predictions and tools are the first step to advance rational and optimized use of tPCS and CES.

  1. Numerical study of magnetic reconnection process near in- terplanetary current sheet

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The third order accurate upwind compact difference scheme has been applied to the numerical study of the magnetic reconnection process possibly occurring near the interplanetary current sheet, under the framework of the two-dimensional compressible magnetohydrodynamics (MHD). Our results here show that the driven reconnection near the current sheet can occur within 10-30 min for the interplanetary high magnetic Reynolds number, RM =2 000-10 000, the stable magnetic reconnection structure can be formed in hour-order of magnitude, and there are some ba- sic properties such as the multiple X-line reconnections, vortical velocity structures, filament current systems, split-ting and collapse of the high-density plasma bulk. These results are helpful in understanding and identifying the magnetic reconnection phenomena near the interplanetary current sheets.

  2. Transcranial direct-current stimulation induced in stroke patients with aphasia: a prospective experimental cohort study

    Directory of Open Access Journals (Sweden)

    Michele Devido Santos

    Full Text Available CONTEXT AND OBJECTIVE: Previous animal and human studies have shown that transcranial direct current stimulation can induce significant and lasting neuroplasticity and may improve language recovery in patients with aphasia. The objective of the study was to describe a cohort of patients with aphasia after stroke who were treated with transcranial direct current stimulation. DESIGN AND SETTING: Prospective cohort study developed in a public university hospital. METHODS: Nineteen patients with chronic aphasia received 10 transcranial direct current stimulation sessions lasting 20 minutes each on consecutive days, using a current of 2 mA. The anode was positioned over the supraorbital area and the cathode over the contralateral motor cortex. The following variables were analyzed before and after the 10 neuromodulation sessions: oral language comprehension, copying, dictation, reading, writing, naming and verbal fluency. RESULTS: There were no adverse effects in the study. We found statistically significant differences from before to after stimulation in relation to simple sentence comprehension (P = 0.034, naming (P = 0.041 and verbal fluency for names of animals (P = 0.038. Improved scores for performing these three tasks were seen after stimulation. CONCLUSIONS: We observed that excitability of the primary motor cortex through transcranial direct current stimulation was associated with effects on different aspects of language. This can contribute towards future testing in randomized controlled trials.

  3. Semi-automatic determination of the Azores Current axis using satellite altimetry: Application to the study of the current variability during 1995-2006

    Science.gov (United States)

    Lázaro, C.; Juliano, M. F.; Fernandes, M. J.

    2013-06-01

    Satellite altimetry has been widely used to study the variability of the ocean currents such as the Azores Current (AzC) in the North Atlantic. Most analyses are performed over the region that encloses the current, thus being somehow affected by other oceanographic signals, e.g., eddies. In this study, a new approach for extracting the axis of a zonal current solely based on satellite altimetry is presented. This is a semi-automatic procedure that searches for the maximum values of the gradient of absolute dynamic topography (ADT), using the geostrophic velocity as auxiliary information. The advantage of this approach is to allow the analyses to be performed over a buffer centered on the current axis instead of using a wider region. It is here applied to the AzC for the period June 1995-October 2006.

  4. The Return-Stroke of Lightning Current, Source of Electromagnetic Fields (Study, Analysis and Modelling

    Directory of Open Access Journals (Sweden)

    Dib Djalel

    2007-01-01

    Full Text Available In this study we present and analysis of the return-stroke lightning current and described their models which existing in the literature by several authors for the evaluation of radiated electromagnetic fields and modelling the coupling with electrical systems based on the calculation of induced voltages. the objective of this work was to take part in the improvement of the coordination of electric insulations and to put device also for calculation of the over-voltages induced in the electrical networks by the indirect lightning strokes which represent the most dangerous constraint and most frequent. A comparative study between the existing models and the analysis of the parameters which affect the space and temporal behaviour of the current lightning strokes as well as the importance of the lightning current at the channel base form the essential consequence of this study.

  5. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

    DEFF Research Database (Denmark)

    Heid, Iris M; Huth, Cornelia; Loos, Ruth J F

    2009-01-01

    The INSIG2 rs7566605 polymorphism was identified for obesity (BMI> or =30 kg/m(2)) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34 studies (n = 74,345), including general population (GP) studies, population-based studies wit...

  6. Blood pressure and lipid management fall far short in persons with type 2 diabetes: results from the DIAB-CORE Consortium including six German population-based studies

    Directory of Open Access Journals (Sweden)

    Rückert Ina-Maria

    2012-05-01

    Full Text Available Abstract Background Although most deaths among patients with type 2 diabetes (T2D are attributable to cardiovascular disease, modifiable cardiovascular risk factors appear to be inadequately treated in medical practice. The aim of this study was to describe hypertension, dyslipidemia and medical treatment of these conditions in a large population-based sample. Methods The present analysis was based on the DIAB-CORE project, in which data from five regional population-based studies and one nationwide German study were pooled. All studies were conducted between 1997 and 2006. We assessed the frequencies of risk factors and co-morbidities, especially hypertension and dyslipidemia, in participants with and without T2D. The odds of no or insufficient treatment and the odds of pharmacotherapy were computed using multivariable logistic regression models. Types of medication regimens were described. Results The pooled data set comprised individual data of 15, 071 participants aged 45–74 years, including 1287 (8.5% participants with T2D. Subjects with T2D were significantly more likely to have untreated or insufficiently treated hypertension, i.e. blood pressure of > = 140/90 mmHg (OR = 1.43, 95% CI 1.26-1.61 and dyslipidemia i.e. a total cholesterol/HDL-cholesterol ratio > = 5 (OR = 1.80, 95% CI 1.59-2.04 than participants without T2D. Untreated or insufficiently treated blood pressure was observed in 48.9% of participants without T2D and in 63.6% of participants with T2D. In this latter group, 28.0% did not receive anti-hypertensive medication and 72.0% were insufficiently treated. In non-T2D participants, 28.8% had untreated or insufficiently treated dyslipidemia. Of all participants with T2D 42.5% had currently elevated lipids, 80.3% of these were untreated and 19.7% were insufficiently treated. Conclusions Blood pressure and lipid management fall short especially in persons with T2D across Germany. The importance of sufficient

  7. Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes.

    Science.gov (United States)

    Hood, Kerenza; Nuttall, Jacqui; Gillespie, David; Shepherd, Victoria; Wood, Fiona; Duncan, Donna; Stanton, Helen; Espinasse, Aude; Wootton, Mandy; Acharjya, Aruna; Allen, Stephen; Bayer, Antony; Carter, Ben; Cohen, David; Francis, Nick; Howe, Robin; Mantzourani, Efi; Thomas-Jones, Emma; Toghill, Alun; Butler, Christopher C

    2014-01-01

    carriage confirmed on stool culture. RESULTS Stool samples were obtained at study entry from 81% of participating residents. Over half of the samples contained antibiotic-resistant isolates, with Enterobacteriaceae resistant to ciprofloxacin in 47%. Residents were prescribed an average of 2.16 antibiotic prescriptions per year [95% confidence interval (CI) 1.90 to 2.46]. Antibiotics were less likely to be prescribed to residents from dual-registered homes. The incidence of AAD was 0.57 (95% CI 0.41 to 0.81) episodes per year among those residents who were prescribed antibiotics. AAD was more likely in residents who were prescribed co-amoxiclav than other antibiotics and in those residents who routinely used incontinence pads. AAD was less common in residents from residential homes. CONCLUSIONS Care home residents, particularly in nursing homes, are frequently prescribed antibiotics and often experience AAD. Antibiotic resistance, including ciprofloxacin resistance, is common in Enterobacteriaceae isolated from the stool of care home residents. Co-amoxiclav is associated with greater risk of AAD than other commonly prescribed antibiotics. TRIAL REGISTRATION Current Controlled Trials ISRCTN 7954844. FUNDING This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 18, No. 63. See the NIHR Journals Library website for further project information. PMID:25331573

  8. Study of magnetic fields and current in the Z pinch at stagnation

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, V. V.; Anderson, A. A.; Astanovitskiy, A. L.; Nalajala, V.; Dmitriev, O. [Department of Physics, University of Nevada, Reno, Nevada 89557 (United States); Papp, D. [Department of Physics, University of Nevada, Reno, Nevada 89557 (United States); ELI-ALPS, ELI-Hu Nkft., H-6720 Szeged (Hungary)

    2015-09-15

    The structure of magnetic fields in wire-array Z pinches at stagnation was studied using a Faraday rotation diagnostic at the wavelength of 266 nm. The electron plasma density and the Faraday rotation angle in plasma were calculated from images of the three-channel polarimeter. The magnetic field was reconstructed with Abel transform, and the current was estimated using a simple model. Several shots with wire-array Z pinches at 0.5–1.5 MA were analyzed. The strength of the magnetic field measured in plasma of the stagnated pinch was in the range of 1–2 MG. The magnetic field and current profile in plasma near the neck on the pinch were reconstructed, and the size of the current-carrying plasma was estimated. It was found that current flowed in the large-size trailing plasma near the dense neck. Measurements of the magnetic field near the bulge on the pinch also showed current in trailing plasma. A distribution of current in the large-size trailing plasma can prevent the formation of multi-MG fields in the Z pinch.

  9. Experimental study of the velocity of density currents in convergent and divergent channels

    Institute of Scientific and Technical Information of China (English)

    Hasan Torabi POUDEH; Samad EMAMGHOLIZADEH; Manoocher Fathi-MOGHADAM

    2014-01-01

    The head velocity of the density current in the convergent and divergent channel is a key parameter for evaluating the extent to which suspended material travels, and for determining the type and distribution of sediment in the water body. This study experimentally evaluated the effects of the reach degree of convergence and divergence on the head velocity of the density current. Experiments were conducted in the flume with 6.0 m long, 0.72 m width and 0.6 m height. The head velocity was measured at three convergent degrees (-8o;-12o;-26o), at three divergent degrees (8o; 12o; 26o) and two slopes (0.009, 0.016) for various discharges. The measured head velocity of the density current is compared with the head velocity of the density current in the constant cross section channel. Based on non-dimensional and statistical analysis, relations as linear multiple regression are offered for predicting head velocity of the density current in the convergent, divergent and constant cross section channel. Also the results of this research show that for the same slope and discharge, the head velocity of the density current in the convergent and divergent channel are greater and less than the head velocity of the constant cross section, respectively.

  10. An observational study of a shallow gravity current triggered by katabatic flow

    Directory of Open Access Journals (Sweden)

    A. Adachi

    2004-11-01

    Full Text Available Observations from a wind profiler and a meteorological tower are utilized to study the evolution of a gravity current that passed over the Meteorological Research Institute's (MRI field site in Tsukuba, Japan. The gravity current was created by katabatic flow originating on the mountainous slopes west of the field site. The passage of the shallow current was marked by a pronounced pressure disturbance and was accompanied by vertical circulations seen in the tower and profiler data. Direct vertical-beam measurements are difficult, especially at low heights during high-gradient events like density currents. In this study vertical velocities from the profiler are derived from the four oblique beams by use of the Minimizing the Variance of the Differences (MVD method. The vertical velocities derived from the MVD method agree well with in situ vertical velocities measured by a sonic anemometer on the tower.

    The gravity current is analyzed with surface observations, the wind profiler/RASS and tower-mounted instruments. Observations from the profiler/RASS and the tower-mounted instruments illustrate the structure of the gravity current in both wind and temperature fields. The profiler data reveal that there were three regions of waves in the vertical velocity field: lee-type waves, a solitary wave and Kelvin-Helmholtz waves. The lee-type waves in the head region of the gravity current seem to have been generated by the gravity current acting as an obstacle to prefrontal flow. The solitary wave was formed from the elevated head of the gravity current that separated from the feeder flow. Profiler vertical-motion observations resolve this wave and enable us to classify it as a Benjamin-Davis-Ono (BDO type solitary wave. The ducting mechanism that enabled the solitary wave to propagate is also revealed from the wind profiler/RASS measurements. The combination of high-resolution instruments at the MRI site allow us to

  11. Experimental study of a high-current FEM with a broadband microwave system

    Energy Technology Data Exchange (ETDEWEB)

    Denisov, G.G.; Bratman, V.L.; Ginzburg, N.S. [Institute of Applied Physics, Nizhny Novgorod (Russian Federation)] [and others

    1995-12-31

    One of the main features of FELs and FEMs is the possibility of fast and wideband tuning of the resonant frequency of active media, which can be provided by changing the particle energy. For a frequency adjustable FEM-oscillator, a broadband microwave system, which is simply combined with an electron-optical FEM system and consists of an oversized waveguide and reflectors based on the microwave beams multiplication effect has been proposed and studied successfully in {open_quotes}cold{close_quotes} measurements. Here, the operating ability of a cavity, that includes some key elements of the broadband microwave system, was tested in the presence of an electron beam. To provide large particle oscillation velocities in a moderate undulator field and the presence of a guide magnetic field, the FEM operating regime of double resonance was chosen. In this regime the cyclotron as well as undulator resonance conditions were satisfied. The FEM-oscillator was investigated experimentally on a high-current accelerator {open_quotes}Sinus-6{close_quotes} that forms an electron beam with particle energy 500keV and pulse duration 25ns. The aperture with a diameter 2.5mm at the center of the anode allows to pass through only the central fraction of the electron beam with a current about 100A and a small spread of longitudinal velocities of the particles. Operating transverse velocity was pumped into the electron beam in the pulse plane undulator of a 2.4cm period. The cavity with a frequency near 45GHz consists of a square waveguide and two reflectors. The broadband up-stream reflector based on the multiplication effect had the power reflectivity coefficient more than 90% in the frequency band 10% for the H{sup 10} wave of the square waveguide with the maximum about 100% at a frequency 45GHz. The down-stream narrow-band Bragg reflector had the power reflection coefficient approximately 80% in the frequency band of 4% near 45GHz for the operating mode.

  12. The Humboldt Current System: Ecosystem components and processes, fisheries, and sediment studies

    Science.gov (United States)

    Montecino, Vivian; Lange, Carina B.

    2009-12-01

    In the Humboldt Current System (HCS), biological and non-biological components, ecosystem processes, and fisheries are known to be affected by multi-decadal, inter-annual, annual, and intra-seasonal scales. The interplay between atmospheric variability, the poleward undercurrent, the shallow oxygen minimum zone (OMZ), and the fertilizing effect of coastal upwelling and overall high primary production rates drive bio-physical interactions, the carbon biomass, and fluxes of gases and particulate and dissolved matter through the water column. Coastal upwelling (permanent and seasonally modulated off Peru and northern Chile, and markedly seasonal between 30°S and 40°S) is the key process responsible for the high biological productivity in the HCS. At present, the western coast of South America produces more fish per unit area than any other region in the world ocean (i.e. ∼7.5 × 10 6 t of anchoveta were landed in 2007). Climate changes on different temporal scales lead to alterations in the distribution ranges of anchoveta and sardine populations and shifts in their dominance throughout the HCS. The factors affecting the coastal marine ecosystem that reverberate in the fisheries are crucial from a social perspective, since the economic consequences of mismanagement can be severe. Fish remains are often well-preserved in sediment settings under the hypoxic conditions of the OMZ off Peru and Chile, and reveal multi-decadal variability and centennial-scale changes in fish populations. Sediment studies from the Chilean continental margin encompassing the last 20,000 years of deposition reveal changes in sub-surface conditions in the HCS during deglaciation, interpreted to include: a major reorganization of the OMZ; a deglacial increase in denitrification decoupled from local marine productivity; and higher deglacial and Holocene paleoproductivities compared to the Last Glacial Maximum in central-south Chile (35-37°S) while this scheme is reversed for north

  13. A study on current situations of college students' foreign language anxiety

    Institute of Scientific and Technical Information of China (English)

    Bi Ran

    2015-01-01

    An empirical study on current situations of college students' foreign language anxiety is concerned with in this paper. The author adopted Horwitz's Foreign Language Classroom Anxiety Scale (FLCAS) to measure the level of foreign language anxiety of 325 participants and then the conclusions are drawn.

  14. A historical study to understand students’ current difficulties about RMS values

    Science.gov (United States)

    Khantine-Langlois, Françoise; Munier, Valérie

    2016-07-01

    Several studies show that students experience more and more difficulties managing the measurements of electrical values in alternating current and that they have trouble making links between theory and practice. They find it difficult to give meaning to root mean square (RMS; or effective) values, which are not understood as average values and are confused with instantaneous values. This shows that students do not clearly differentiate variable and direct currents. In this paper we try, with a historical study and a study of teaching the concept of RMS values, to understand students’ difficulties with this concept. In the first part we present an epistemological analysis of the concept of RMS values, showing that it is multifaceted and can be approached from different points of view. In the second part we analyse the evolution of French secondary school curricula and textbooks from the explicit introduction of variable currents to today, questioning the links between the evolution of the curricula and the evolution of the place of science and technology in our societies. We point out that the evolution of the curricula is linked to the social context and to the connections between science, technology and society, and also to the relationship with mathematics curricula. We show that alternating current is introduced earlier in the curriculum but has gradually lost all phenomenological description. This study allows us to better understand students’ difficulties and to discuss some implications for teaching.

  15. Understandings of Current Environmental Issues: Turkish Case Study in Six Teacher Education Colleges

    Science.gov (United States)

    Cakir, Mustafa; Irez, Serhat; Dogan, Ozgur Kivilcan

    2010-01-01

    The purpose of this study is to profile future science teachers' understandings of current environmental issues in the context of an education reform in Turkey. Knowledge base and understandings of elementary and secondary prospective science teachers about biodiversity, carbon cycle, global warming and ozone layer depletion were targeted in the…

  16. Study of multipass regimes in lower hybrid current drive experiments on Tore Supra

    Energy Technology Data Exchange (ETDEWEB)

    Arslanbekov, R.; Litaudon, X.; Peysson, Y.; Hoang, G.T.; Kazarian, F.; Moreau, D. [Association Euratom-CEA, Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee; Shoucri, M.; Shkarofsky, I.P. [Centre Canadien de Fusion Magnetique, Varennes, PQ (Canada); Baranov, Y. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Kupfer, K. [General Atomics, San Diego, CA (United States)

    1995-12-31

    This document presents a study of multipass regimes in Lower Hybrid Current Drive on Tore Supra. A statistical model of the plasma wave propagation based on the Fokker-Planck theory is proposed, together with experimental results performed on Tore Supra. (TEC). 9 refs., 4 figs.

  17. Transcranial direct current stimulation in refractory continuous spikes and waves during slow sleep: a controlled study

    DEFF Research Database (Denmark)

    Varga, Edina T; Terney, Daniella; Atkins, Mary D

    2011-01-01

    Cathodal transcranial direct current stimulation (tDCS) decreases cortical excitability. The purpose of the study was to investigate whether cathodal tDCS could interrupt the continuous epileptiform activity. Five patients with focal, refractory continuous spikes and waves during slow sleep were ...

  18. Relevance of animal studies in regulatory toxicology : current approaches and future opportunities

    NARCIS (Netherlands)

    Sandt, J.J.M. van de; Feron, V.J.

    1996-01-01

    With rapidly increasing knowledge of toxicological processes, the scientific value and relevance of toxicity studies for risk assessment must be re-evaluated. In this paper, it is proposed that the rigid risk evaluation currently required should be replaced by a more flexible, case-by-case approach,

  19. Study of transient current induced by heavy-ion microbeams in Si and GaAs

    Energy Technology Data Exchange (ETDEWEB)

    Hirao, Toshio; Nashiyama, Isamu; Kamiya, Tomihiro; Suda, Tamotu [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1997-03-01

    Heavy-ion microbeams were applied to the study of mechanism of single event upset (SEU). Transient current induced in p{sup +}n junction diodes by strike of heavy ion microbeam were measured by using a high-speed digitizing sampling system. (author)

  20. A Focus Group Study of Child Nutrition Professionals' Attitudes about Food Allergies and Current Training Practices

    Science.gov (United States)

    Lee, Yee Ming; Kwon, Junehee; Sauer, Kevin

    2014-01-01

    Purpose/Objectives: The purpose of this study was to explore child nutrition professionals' (CNPs) attitudes about food allergies, current practices of food allergy training, and operational issues related to food allergy training in school foodservice operations. Methods: Three focus groups were conducted with 21 CNPs with managerial…

  1. Field Study on the Effects of Waves and Currents on a Distributed Explosive Array

    Science.gov (United States)

    1993-12-01

    taken during each deployment. Table 1 Summary of Video Camera Resources Used During Study Camra ID [LoGato Formal Availabilty BWTEL Top of tower Black... usage . First, the offshore-flowing current would help extend the array seaward from the rocket anchors while reducing the longshore deformation

  2. Some Gaps in the Current Studies of Reading in Second/Foreign Language Learning

    Science.gov (United States)

    Fazeli, Seyed Hossein

    2010-01-01

    The ability to read written material is very important in the civilized world. In a society characterized by globalization and technological change, where knowledge is becoming increasingly important, reading ability is a key skill for active participation. The intent of the current study is to set out the nature of reading alongside express…

  3. Meta-analysis approach to study the prevalence of chronic obstructive pulmonary disease among current, former and non-smokers

    Directory of Open Access Journals (Sweden)

    Ritul Kamal

    2015-01-01

    Full Text Available Comparative risk assessment for Chronic Obstructive Pulmonary Disease (COPD among current, former and non-smokers categories remains controversial and not studied in detail. We conducted a meta-analysis to summarize all the relevant published studies on this topic and to update the association between smoking and prevalence of COPD in current, former and non-smokers. Identification, screening, eligibility and inclusion of articles for the study were conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA guidelines. Quality assessment of included studies was undertaken using a scoring sheet. Meta-analysis after the final synthesis of the selected studies was performed using the STATA and Comprehensive Meta-Analysis (CMA software. Estimates from forty two independent studies reporting 547,391 individuals were identified. Twenty two studies were conducted in Europe, nine in America and ten in Asia and one from New Zealand. The meta-analysis showed that the prevalence of COPD was significantly higher in current smokers compared with former and non-smokers. However, owing to large heterogeneity among the estimates obtained from the studies, stratification was done with respect to continent, diagnostic criteria of COPD and study design which also showed similar results. The stratified analysis also revealed similar trend of results with prevalence of COPD being higher in current smokers as compared to former and non-smokers. The present meta-analysis highlights the positive association between smoking and COPD prevalence. There is an urgent need to implement more effective policies towards the restriction of tobacco use, to reduce the burden of COPD.

  4. Current Situation and Evaluation of Clinical Studies on Acupuncture and Moxibustion Treatment of Peripheral Facial Paralysis at Selected Stages

    Institute of Scientific and Technical Information of China (English)

    LI Ying; WU Xi; HU Ka-ming; CHEN Xiao-qin

    2010-01-01

    @@ Peripheral facial paralysis is a frequently encountered disease with a high incidence, and it is one of the most common diseases in acupuncture and moxibustion treatment. Because there are rich literatures in clinical studies on acupuncture and moxibustion treatment for this disease, and clinically, it is divided into different stages, in the present paper the current situation of clinical studies about acupuncture and moxibustion treatment for peripheral facial paralysis according to different stages in resent years are analyzed and evaluated including the stage division,the optimal time for treatment, location of injured nerves and assessment of the therapeutic effect, etc.

  5. A New Regime for Studying the High Bootstrap Current Fraction Plasma

    Institute of Scientific and Technical Information of China (English)

    A. Isayama; Y. Kamada; K. Ushigusa; T. Fujita; T. Suzuki; X. Gao

    2001-01-01

    A new experimental regime has recently been studied for achieving the high fraction of the bootstrap current in the JT-60U hydrogen discharges. The high poloidal beta(βp ~ 3.61) plasma was obtained by high-power neutral beam injection heating at a very high edge safety factor (Ip = 0.3 MA, Bt = 3.65 T, qeff = 25 - 35) region, and the bootstrap current fraction (fBS) was correspondingly about 40% using the ACCOME code calculation. It was observed that there were no magnetohydrodynamic instabilities to retard the increase of the βp and fBS parameters in the new regime.

  6. A Study of Strange Particles Produced in Neutrino Neutral Current Interactions in the NOMAD Experiment

    CERN Document Server

    Naumov, D V; Naumova, E; Popov, B; Astier, Pierre; Autiero, D; Baldisseri, Alberto; Baldo-Ceolin, Massimilla; Banner, M; Bassompierre, G; Benslama, K; Besson, N; Bird, I; Blumenfeld, B; Bobisut, F; Bouchez, J; Boyd, S; Bueno, A G; Bunyatov, S; Camilleri, L L; Cardini, A; Cattaneo, P W; Cavasinni, V; Cervera-Villanueva, A; Challis, R C; Collazuol, G; Conforto, G; Conta, C; Contalbrigo, M; Cousins, R; Daniels, D; Das, R; Degaudenzi, H M; Del Prete, T; De Santo, A; Dignan, T; Di Lella, L; do Couto e Silva, E; Dumarchez, J; Ellis, M; Feldman, G J; Ferrari, R; Ferrère, D; Flaminio, V; Fraternali, M; Gaillard, J M; Gangler, E; Geiser, A; Geppert, D; Gibin, D; Gninenko, S; Godley, A; Gómez-Cadenas, J J; Gosset, J; Gössling, C; Gouanère, M; Grant, A; Graziani, G; Guglielmi, A M; Hagner, C; Hernando, J; Hong, T M; Hubbard, D B; Hurst, P; Hyett, N; Iacopini, E; Joseph, C L; Juget, F R; Kent, N; Kirsanov, M; Klimov, O; Kokkonen, J; Kovzelev, A; Krasnoperov, A V; Lacaprara, S; Lachaud, C; Lakic, B; Lanza, A; La Rotonda, L; Laveder, M; Letessier-Selvon, A A; Lévy, J M; Linssen, Lucie; Ljubicic, A; Long, J; Lupi, A; Lyubushkin, V V; Marchionni, A; Martelli, F; Méchain, X; Mendiburu, J P; Meyer, J P; Mezzetto, Mauro; Mishra, S R; Moorhead, G F; Nédélec, P; Nefedov, Yu A; Nguyen-Mau, C; Orestano, D; Pastore, F; Peak, L S; Pennacchio, E; Pessard, H; Petti, R; Placci, A; Polesello, G; Pollmann, D; Polyarush, A Yu; Poulsen, C; Rebuffi, L; Rico, J; Roda, C; Rubbia, André; Salvatore, F; Schahmaneche, K; Schmidt, B; Schmidt, T; Sconza, A; Sevior, M E; Shih, D; Sillou, D; Soler, F J P; Sozzi, G; Steele, D; Stiegler, U; Stipcevic, M; Stolarczyk, T; Tareb-Reyes, M; Taylor, G N; Tereshchenko, V V; Toropin, A N; Touchard, A M; Tovey, Stuart N; Tran, M T; Tsesmelis, E; Ulrichs, J; Vacavant, L; Valdata-Nappi, M; Valuev, V Yu; Vannucci, François; Varvell, K E; Veltri, M; Vercesi, V; Vidal-Sitjes, G; Vieira, J M; Vinogradova, T G; Weber, F V; Weisse, T; Wilson, F F; Winton, L J; Yabsley, B D; Zaccone, Henri; Zuber, K; Zuccon, P

    2004-01-01

    Results of a detailed study of strange particle production in neutrino neutral current interactions are presented using the data from the NOMAD experiment. Integral yields of neutral strange particles (K0s, Lambda, Lambda-bar) have been measured. Decays of resonances and heavy hyperons with an identified K0s or Lambda in the final state have been analyzed. Clear signals corresponding to K* and Sigma(1385) have been observed. First results on the measurements of the Lambda polarization in neutral current interactions have been obtained.

  7. A study of strange particles produced in neutrino neutral current interactions in the NOMAD experiment

    Science.gov (United States)

    Naumov, D.; Chukanov, A.; Naumova, E.; Popov, B.; Astier, P.; Autiero, D.; Baldisseri, A.; Baldo-Ceolin, M.; Banner, M.; Bassompierre, G.; Benslama, K.; Besson, N.; Bird, I.; Blumenfeld, B.; Bobisut, F.; Bouchez, J.; Boyd, S.; Bueno, A.; Bunyatov, S.; Camilleri, L.; Cardini, A.; Cattaneo, P. W.; Cavasinni, V.; Cervera-Villanueva, A.; Challis, R.; Collazuol, G.; Conforto, G.; Conta, C.; Contalbrigo, M.; Cousins, R.; Daniels, D.; Das, R.; Degaudenzi, H.; Del Prete, T.; de Santo, A.; Dignan, T.; di Lella, L.; Do Couto E Silva, E.; Dumarchez, J.; Ellis, M.; Feldman, G. J.; Ferrari, R.; Ferrère, D.; Flaminio, V.; Fraternali, M.; Gaillard, J.-M.; Gangler, E.; Geiser, A.; Geppert, D.; Gibin, D.; Gninenko, S.; Godley, A.; Gomez-Cadenas, J.-J.; Gosset, J.; Gößling, C.; Gouanère, M.; Grant, A.; Graziani, G.; Guglielmi, A.; Hagner, C.; Hernando, J.; Hong, T. M.; Hubbard, D.; Hurst, P.; Hyett, N.; Iacopini, E.; Joseph, C.; Juget, F.; Kent, N.; Kirsanov, M.; Klimov, O.; Kokkonen, J.; Kovzelev, A.; Krasnoperov, A.; Lacaprara, S.; Lachaud, C.; Lakić, B.; Lanza, A.; La Rotonda, L.; Laveder, M.; Letessier-Selvon, A.; Levy, J.-M.; Linssen, L.; Ljubičić, A.; Long, J.; Lupi, A.; Lyubushkin, V.; Marchionni, A.; Martelli, F.; Méchain, X.; Mendiburu, J.-P.; Meyer, J.-P.; Mezzetto, M.; Mishra, S. R.; Moorhead, G. F.; Nédélec, P.; Nefedov, Yu.; Nguyen-Mau, C.; Orestano, D.; Pastore, F.; Peak, L. S.; Pennacchio, E.; Pessard, H.; Petti, R.; Placci, A.; Polesello, G.; Pollmann, D.; Polyarush, A.; Poulsen, C.; Rebuffi, L.; Rico, J.; Riemann, P.; Roda, C.; Rubbia, A.; Salvatore, F.; Schahmaneche, K.; Schmidt, B.; Schmidt, T.; Sconza, A.; Sevior, M.; Shih, D.; Sillou, D.; Soler, F. J. P.; Sozzi, G.; Steele, D.; Stiegler, U.; Stipčević, M.; Stolarczyk, Th.; Tareb-Reyes, M.; Taylor, G. N.; Tereshchenko, V.; Toropin, A.; Touchard, A.-M.; Tovey, S. N.; Tran, M.-T.; Tsesmelis, E.; Ulrichs, J.; Vacavant, L.; Valdata-Nappi, M.; Valuev, V.; Vannucci, F.; Varvell, K. E.; Veltri, M.; Vercesi, V.; Vidal-Sitjes, G.; Vieira, J.-M.; Vinogradova, T.; Weber, F. V.; Weisse, T.; Wilson, F. F.; Winton, L. J.; Yabsley, B. D.; Zaccone, H.; Zuber, K.; Zuccon, P.; NOMAD Collaboration

    2004-11-01

    Results of a detailed study of strange particle production in neutrino neutral current interactions are presented using the data from the NOMAD experiment. Integral yields of neutral strange particles ( Ks0, Λ, Λ¯) have been measured. Decays of resonances and heavy hyperons with an identified Ks0 or Λ in the final state have been analyzed. Clear signals corresponding to K and Σ(1385 have been observed. First results on the measurements of the Λ polarization in neutral current interactions have been obtained.

  8. Longitudinal study of spatially heterogeneous emphysema progression in current smokers with chronic obstructive pulmonary disease.

    Directory of Open Access Journals (Sweden)

    Naoya Tanabe

    Full Text Available BACKGROUND: Cigarette smoke is the main risk factor for emphysema, which is a key pathology in chronic obstructive pulmonary disease (COPD. Low attenuation areas (LAA in computed tomography (CT images reflect emphysema, and the cumulative size distribution of LAA clusters follows a power law characterized by the exponent D. This property of LAA clusters can be explained by model simulation, where mechanical force breaks alveolar walls causing local heterogeneous lung tissue destruction. However, a longitudinal CT study has not investigated whether continuous smoking causes the spatially heterogeneous progression of emphysema. METHODS: We measured annual changes in ratios of LAA (LAA%, D and numbers of LAA clusters (LAN in CT images acquired at intervals of ≥ 3 years from 22 current and 31 former smokers with COPD to assess emphysema progression. We constructed model simulations using CT images to morphologically interpret changes in current smokers. RESULTS: D was decreased in current and former smokers, whereas LAA% and LAN were increased only in current smokers. The annual changes in LAA%, D, and LAN were greater in current, than in former smokers (1.03 vs. 0.37%, p=0.008; -0.045 vs. -0.01, p=0.004; 13.9 vs. 1.1, p=0.007, respectively. When LAA% increased in model simulations, the coalescence of neighboring LAA clusters decreased D, but the combination of changes in D and LAN in current smokers could not be explained by the homogeneous emphysema progression model despite cluster coalescence. Conversely, a model in which LAAs heterogeneously increased and LAA clusters merged somewhat in relatively advanced emphysematous regions could reflect actual changes. CONCLUSIONS: Susceptibility to parenchymal destruction induced by continuous smoking is not uniform over the lung, but might be higher in local regions of relatively advanced emphysema. These could result in the spatially heterogeneous progression of emphysema in current smokers.

  9. Are current atomistic force fields accurate enough to study proteins in crowded environments?

    Directory of Open Access Journals (Sweden)

    Drazen Petrov

    2014-05-01

    Full Text Available The high concentration of macromolecules in the crowded cellular interior influences different thermodynamic and kinetic properties of proteins, including their structural stabilities, intermolecular binding affinities and enzymatic rates. Moreover, various structural biology methods, such as NMR or different spectroscopies, typically involve samples with relatively high protein concentration. Due to large sampling requirements, however, the accuracy of classical molecular dynamics (MD simulations in capturing protein behavior at high concentration still remains largely untested. Here, we use explicit-solvent MD simulations and a total of 6.4 µs of simulated time to study wild-type (folded and oxidatively damaged (unfolded forms of villin headpiece at 6 mM and 9.2 mM protein concentration. We first perform an exhaustive set of simulations with multiple protein molecules in the simulation box using GROMOS 45a3 and 54a7 force fields together with different types of electrostatics treatment and solution ionic strengths. Surprisingly, the two villin headpiece variants exhibit similar aggregation behavior, despite the fact that their estimated aggregation propensities markedly differ. Importantly, regardless of the simulation protocol applied, wild-type villin headpiece consistently aggregates even under conditions at which it is experimentally known to be soluble. We demonstrate that aggregation is accompanied by a large decrease in the total potential energy, with not only hydrophobic, but also polar residues and backbone contributing substantially. The same effect is directly observed for two other major atomistic force fields (AMBER99SB-ILDN and CHARMM22-CMAP as well as indirectly shown for additional two (AMBER94, OPLS-AAL, and is possibly due to a general overestimation of the potential energy of protein-protein interactions at the expense of water-water and water-protein interactions. Overall, our results suggest that current MD force fields

  10. Computational and experimental studies of laser cutting of the current collectors for lithium-ion batteries

    Science.gov (United States)

    Lee, Dongkyoung; Patwa, Rahul; Herfurth, Hans; Mazumder, Jyotirmoy

    2012-07-01

    Sizing electrodes is an important step during Lithium-ion battery manufacturing processes since poor cut edge affects battery performance significantly and sometime leads to fire hazard. Mechanical cutting could result in a poor cut quality with defects. The cutting quality can be improved by using a laser, due to its high energy concentration, fast processing time, small heat-affected zone, and high precision. The cutting quality is highly influenced by operating parameters such as laser power and scanning speed. Thus, we studied a numerical simulation to provide a guideline for achieving clear edge quality. In order to simulate electrodes laser cutting for Lithium-Ion batteries, understanding the behavior of current collectors is crucial. This study focuses on current collectors, such as pure copper and aluminium. Numerical studies utilized a 3D self-consistent mathematical model for laser-material interaction. Observations of penetration time, depth, and threshold during laser cutting processes of current collectors are described. The model is validated experimentally by cutting current collectors and single side-coated electrodes with a single mode fiber laser. The copper laser cutting is laser intensity and interaction time dependent process. The aluminium laser cutting depends more on laser intensity than the interaction time. Numerical and experimental results show good agreement.

  11. Quantitative study of electrophoretic and electroosmotic enhancement during alternating current iontophoresis across synthetic membranes.

    Science.gov (United States)

    Yan, Guang; Li, S Kevin; Peck, Kendall D; Zhu, Honggang; Higuchi, William I

    2004-12-01

    One of the primary safety and tolerability limitations of direct current iontophoresis is the potential for electrochemical burns associated with the necessary current densities and/or application times required for effective treatment. Alternating current (AC) transdermal iontophoresis has the potential to eliminate electrochemical burns that are frequently observed during direct current transdermal iontophoresis. Although it has been demonstrated that the intrinsic permeability of skin can be increased by applying low-to-moderate AC voltages, transdermal transport phenomena and enhancement under AC conditions have not been systematically studied and are not well understood. The aim of the present work was to study the fundamental transport mechanisms of square-wave AC iontophoresis using a synthetic membrane system. The model synthetic membrane used was a composite Nuclepore membrane. AC frequencies ranging from 20 to 1000 Hz and AC fields ranging from 0.25 to 0.5 V/membrane were investigated. A charged permeant, tetraethyl ammonium, and a neutral permeant, arabinose, were used. The transport studies showed that flux was enhanced by increasing the AC voltage and decreasing AC frequency. Two theoretical transport models were developed: one is a homogeneous membrane model; the other is a heterogeneous membrane model. Experimental transport data were compared with computer simulations based on these models. Excellent agreement between model predictions and experimental data was observed when the data were compared with the simulations from the heterogeneous membrane model.

  12. Turbulent Gravity Current of Lock Release Type:A Numerical Study

    Institute of Scientific and Technical Information of China (English)

    G.Q.CHEN; J.H.W.LEE

    1999-01-01

    The time evolution of a turbulent gravity current of lock release type,formed by a finite volume of homogenous fluid released instantaneously into another fluid of slightly lower density,is studied numerically via the renormalization group(RNG)κ-ε model for Reynolds-stress closure to characterize the flow with transitional and highly localized turbulence,Consistent with previous experimental observations,the numerical results show that the gravity current passes through two distinct phases,an initial slumping phase in which the current head advances steadily,and a second self-similar phase in which the front velocity decreases like the negative third power of the time after release.An overall entrainment ratio proportional to the distance from the release point is found and comares well with available experimental data for the slumping phase.

  13. Current Applications of Chromatographic Methods in the Study of Human Body Fluids for Diagnosing Disorders.

    Science.gov (United States)

    Jóźwik, Jagoda; Kałużna-Czaplińska, Joanna

    2016-01-01

    Currently, analysis of various human body fluids is one of the most essential and promising approaches to enable the discovery of biomarkers or pathophysiological mechanisms for disorders and diseases. Analysis of these fluids is challenging due to their complex composition and unique characteristics. Development of new analytical methods in this field has made it possible to analyze body fluids with higher selectivity, sensitivity, and precision. The composition and concentration of analytes in body fluids are most often determined by chromatography-based techniques. There is no doubt that proper use of knowledge that comes from a better understanding of the role of body fluids requires the cooperation of scientists of diverse specializations, including analytical chemists, biologists, and physicians. This article summarizes current knowledge about the application of different chromatographic methods in analyses of a wide range of compounds in human body fluids in order to diagnose certain diseases and disorders.

  14. Study of Security Attributes of Smart Grid Systems- Current Cyber Security Issues

    Energy Technology Data Exchange (ETDEWEB)

    Wayne F. Boyer; Scott A. McBride

    2009-04-01

    This document provides information for a report to congress on Smart Grid security as required by Section 1309 of Title XIII of the Energy Independence and Security Act of 2007. The security of any future Smart Grid is dependent on successfully addressing the cyber security issues associated with the nation’s current power grid. Smart Grid will utilize numerous legacy systems and technologies that are currently installed. Therefore, known vulnerabilities in these legacy systems must be remediated and associated risks mitigated in order to increase the security and success of the Smart Grid. The implementation of Smart Grid will include the deployment of many new technologies and multiple communication infrastructures. This report describes the main technologies that support Smart Grid and summarizes the status of implementation into the existing U.S. electrical infrastructure.

  15. A case control study of premorbid and currently reported physical activity levels in chronic fatigue syndrome

    Directory of Open Access Journals (Sweden)

    Buchwald Dedra

    2006-11-01

    Full Text Available Abstract Background Patients with chronic fatigue syndrome typically report high levels of physical activity before becoming ill. Few studies have examined premorbid and current activity levels in chronically fatigued patients. Methods In a case-control study, 33 patients with chronic, unexplained, disabling fatigue attending a university-based clinic specializing in fatigue were compared to 33 healthy, age- and sex-matched controls. Patients rated their activity levels before their illness and currently, using scales designed for this purpose. Controls reported their level of activity of 2 years previously and currently. Chi-square analyses, Student's t tests, and Wilcoxon signed rank tests were used in pair matched analyses. Results Compared to healthy controls, patients with chronic, unexplained fatigue rated themselves as more active before their illness (p ≤ 0.001 and less active currently (p ≤ 0.001. The patients also reported they currently stood or walked less than the controls (median [inter-quartile range] = 4 2345 versus 9 [7.5–12] hours, p ≤ 0.001, and spent more time reclining (median [inter-quartile range] = 12 10111213141516 versus 8 [8–9.5] hours, p ≤ 0.001. These differences remained significant for the subset of patients who met strict criteria for chronic fatigue syndrome or fibromyalgia. Conclusion Patients with chronic, unexplained, disabling fatigue reported being more active before becoming ill than healthy controls. This finding could be explained by greater premorbid activity levels that could predispose to illness, or by an overestimation of previous activity. Either possibility could influence patients' perceptions of their current activity levels and their judgments of recovery. Perceived activity should be addressed as part of management of the illness.

  16. Prevalence of primary aldosteronism in patient's cohorts and in population-based studies--a review of the current literature.

    Science.gov (United States)

    Hannemann, A; Wallaschofski, H

    2012-03-01

    There is an ongoing controversy on the prevalence of primary aldosteronism (PA). We aimed to update a meta-analysis published in 2008, that compiled studies reporting the prevalence of positive ARR screening tests and PA. We therefore reviewed original studies published in 2008 or later to examine whether current reports provide similar, higher or lower prevalences of elevated ARRs or PA than reports included in the original meta-analysis. A systematic review of English articles using PubMed was conducted. Search and extraction of articles were performed by one review author; the second review author checked all extracted data. We identified 11 eligible studies. The updated, weighted mean prevalences of elevated ARRs and PA in primary care (prevalence of high ARRs 16.5%; prevalence of PA 4.3%) and referred patients (prevalence of high ARRs 19.6%; prevalence of PA 9.5%) were only marginally different from the mean values obtained in the original meta-analysis. Among the current studies the maximum values for the prevalence of elevated ARRs and PA were substantially lower than among the older studies. Our results confirm the main conclusions from the original meta-analysis. The prevalence of PA increases with the severity of hypertension and the inclusion of current study results did not alter the mean prevalences of elevated ARRs and PA in primary care and referred patients. Additionally, we found that current studies focus increasingly on patients in referral centers or special subgroups, while the prevalence of PA in the general hypertensive population is yet unknown.

  17. A Comparative Study of Current and Potential Users of Mobile Payment Services

    Directory of Open Access Journals (Sweden)

    Chanchai Phonthanukitithaworn

    2016-11-01

    Full Text Available Previous studies of mobile payment (m-payment services have primarily focused on a single group of adopters. This study identifies the factors that influence an individual’s intention to use m-payment services and compares groups of current users (adopters with potential users (non-adopters. A research model that reflects the behavioral intention to use m-payment services is developed and empirically tested using structural equation modeling on a data set consisting of 529 potential users and 256 current users of m-payment services in Thailand. The results show that the factors that influence current users’ intentions to use m-payment services are compatibility, subjective norms, perceived trust, and perceived cost. Subjective norms, compatibility, ease of use, and perceived risk influenced potential users’ intentions to use m-payment. Subjective norms and perceived risk had a stronger influence on potential users, while perceived cost had a stronger influence on current users, in terms of their intentions to use m-payment services. Discussions, limitations, and recommendations for future research are addressed.

  18. Study of the flavour changing neutral current beta-s gamma at BaBar

    CERN Document Server

    Smith, D

    2002-01-01

    The main theme of this thesis, is a monte-carlo analysis of the rare Flavour Changing Neutral Current (FCNC) decay b -> s gamma. The analysis develops techniques that could be applied to real data, to discriminate between signal and background events in order to make a measurement of the branching ratio of this rare decay using the BaBar detector. Also included in this thesis is a description of the BaBar detector and the work I have undertaken in the development of the electronic data acquisition system for the Electromagnetic Calorimeter (EMC), a subsystem of the BaBar detector.

  19. Application of the reciprocity theorem to EEG inversion and optimization of EEG-driven transcranial current stimulation (tCS, including tDCS, tACS, tRNS)

    CERN Document Server

    Ruffini, Giulio

    2015-01-01

    Multichannel transcranial current stimulation (tCS) systems offer the possibility of EEG-guided optimized, non-invasive brain stimulation. In this brief technical note I explain how it is possible to use tCS electric field realistic brain model to create a forward "lead-field" matrix and, from that, an EEG inverter for cortical mapping. Starting from EEG I show how to generate 2D cortical surface dipole fields that could produce the observed EEG electrode voltages. The main tool is the reciprocity theorem derived by Helmholtz. The application of reciprocity for the generation of a forward mapping matrix (lead field matrix as is sometimes known) is well known [Rush and Driscoll, 1969], but here we will use it in combination with the realistic head models of [Miranda et al 2013] to provide cortical mapping solutions compatible with realistic head model tCS optimization. I also provide a generalization of the reciprocity theorem [Helmholtz 1853] to the case of multiple electrode contact points and dipole sources...

  20. Review of the Studies about Environmental Education: Current Status in Turkey

    Directory of Open Access Journals (Sweden)

    Esra Kızılay

    2014-12-01

    Full Text Available Purpose of this research is to reveal current status of studies in environmental education, which were published in Turkey between 2007-2011. Within the content of this study, 112 studies were reviewed using content analysis based on the following grouping criteria; i.e., publication year, language, participant, research design, research topic, data gathering instruments and data analysis program. The results indicated that 78% of them were published in Turkish and most of them were at university level (36.2%.A majority of the reviewed studies were about affective domain (31.9%. Quantitative studies (57.1% were very commonly used by the researchers . Questionnaires (45% were the most commonly used data gathering instruments, and SPSS was the most frequently used quantitative data analysis program (88.6%. Presenting an overview of relevant literature, this study may guide the researchers who will conduct further studies on environmental education.

  1. Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies

    Science.gov (United States)

    Katagiri, Ryoko; Yuan, Xiaoyi; Kobayashi, Satomi; Sasaki, Satoshi

    2017-01-01

    Background Although several reports concerning the association of iodine excess and thyroid disease have appeared, no systematic review of the association between iodine excess intake and thyroid diseases, especially hyperthyroidism and hypothyroidism, has yet been reported. Method We conducted a systematic search of Ovid MEDLINE, PubMed, Cochrane Central Register of Controlled Trials databases, Ichushi-Web and CiNii database for intervention trials and observational studies. Search terms were constructed from related words for excess AND iodine intake or excretion AND thyroid hormones or diseases AND study designs. After considering the qualitative heterogeneity among studies, a meta-analysis was conducted and odds ratios and 95% confidence intervals (CI) were estimated in random-effects models. A protocol was registered with PROSPERO (No. CRD42015028081). Results 50 articles were included, including three intervention trials, six case-control studies, six follow-up studies and 35 cross-sectional studies. Three cross-sectional studies in adults included in meta-analysis. Odds ratio of overt and subclinical hypothyroidism between excess and adequate populations were 2.78 (CI:1.47 to 5.27) and 2.03 (CI:1.58 to 2.62) in adults, respectively. Source of excess iodine status was mainly iodized salt or water in included studies. Conclusion Although universal salt iodization has improved goiter rates, chronic exposure to excess iodine from water or poorly monitored salt are risk factors for hypothyroidism in free-living populations. Monitoring of both iodine concentration in salt as well as the iodine concentration in local drinking water are essential to preventing thyroid diseases. Hypothyroidism should be also carefully monitored in areas with excess iodine. Because of the low quality and limited number of included studies, further evidence and review are required. PMID:28282437

  2. Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies.

    Science.gov (United States)

    Katagiri, Ryoko; Yuan, Xiaoyi; Kobayashi, Satomi; Sasaki, Satoshi

    2017-01-01

    Although several reports concerning the association of iodine excess and thyroid disease have appeared, no systematic review of the association between iodine excess intake and thyroid diseases, especially hyperthyroidism and hypothyroidism, has yet been reported. We conducted a systematic search of Ovid MEDLINE, PubMed, Cochrane Central Register of Controlled Trials databases, Ichushi-Web and CiNii database for intervention trials and observational studies. Search terms were constructed from related words for excess AND iodine intake or excretion AND thyroid hormones or diseases AND study designs. After considering the qualitative heterogeneity among studies, a meta-analysis was conducted and odds ratios and 95% confidence intervals (CI) were estimated in random-effects models. A protocol was registered with PROSPERO (No. CRD42015028081). 50 articles were included, including three intervention trials, six case-control studies, six follow-up studies and 35 cross-sectional studies. Three cross-sectional studies in adults included in meta-analysis. Odds ratio of overt and subclinical hypothyroidism between excess and adequate populations were 2.78 (CI:1.47 to 5.27) and 2.03 (CI:1.58 to 2.62) in adults, respectively. Source of excess iodine status was mainly iodized salt or water in included studies. Although universal salt iodization has improved goiter rates, chronic exposure to excess iodine from water or poorly monitored salt are risk factors for hypothyroidism in free-living populations. Monitoring of both iodine concentration in salt as well as the iodine concentration in local drinking water are essential to preventing thyroid diseases. Hypothyroidism should be also carefully monitored in areas with excess iodine. Because of the low quality and limited number of included studies, further evidence and review are required.

  3. Experimental study on hydrodynamic characteristics of vertical-axis floating tidal current energy power generation device

    Science.gov (United States)

    Ma, Yong; Li, Teng-fei; Zhang, Liang; Sheng, Qi-hu; Zhang, Xue-wei; Jiang, Jin

    2016-10-01

    To study the characteristics of attenuation, hydrostatic towage and wave response of the vertical-axis floating tidal current energy power generation device (VAFTCEPGD), a prototype is designed and experiment is carried out in the towing tank. Free decay is conducted to obtain attenuation characteristics of the VAFTCEPGD, and characteristics of mooring forces and motion response, floating condition, especially the lateral displacement of the VAFTCEPGD are obtained from the towing in still water. Tension response of the #1 mooring line and vibration characteristics of the VAFTCEPGD in regular waves as well as in level 4 irregular wave sea state with the current velocity of 0.6 m/s. The results can be reference for theoretical study and engineering applications related to VAFTCEPGD.

  4. EXPERIMENTAL STUDY ON BED-LOAD SEDIMENT TRANSPORT IN IRREGULAR WAVE-CURRENT COEXISTENT FIELD

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    In order to evaluate bed-load sediment transport in an irregular wave-current coexistent field, a series of experiments were completed in laboratory with an irregularly oscillating tray, which was specially designed to simulate the irregular wave-current coexistent field. Experimental results are presented on the initial motion of sediment and the rates of transport over flat horizontal bed. Testing conditions included three interaction angles, 0°, 45°, 90° and six kinds of grain sizes. Four kinds (0.2mm, 0.46mm, 0.85mm and 1.3mm) were used for the tests of initial motion, while the other two kinds (0.38mm and 1.1mm) for the tests of transport rate. Comparisons between experimental results of initial motion and modified Shields curve indicate that the Shields curve is still valid for the case of irregular wave-current coexistent field. Analysis of flow regime shows that initial conditions fall within smooth-turbulent transitional region. The results of transport rate show us that net sediment transport rate can be expressed approximately as the function of the maximum bottom shear stress and mean shear stress. A dimensionless formula is proposed on the basis of mechanism "Waves erode sediments, tides transport sediments".

  5. Study on rejection characteristic of current loop to the base disturbance of optical communication system

    Science.gov (United States)

    Mao, Yao; Deng, Chao; Liu, Qiong; Cao, Zheng

    2016-10-01

    As laser has narrow transmitting beam and small divergence angle, the LOS (Line of Sight) stabilization of optical communication system is a primary precondition of laser communication links. Compound axis control is usually adopted in LOS stabilization of optical communication system, in which coarse tracking and fine tracking are included. Rejection against high frequency disturbance mainly depends on fine tracking LOS stabilization platform. Limited by different factors such as mechanical characteristic of the stabilization platform and bandwidth/noise of the sensor, the control bandwidth of LOS stabilization platform is restricted so that effective rejection of high frequency disturbance cannot be achieved as it mainly depends on the isolation characteristic of the platform itself. It is proposed by this paper that current loop may reject the effect of back-EMF. By adopting the method of electric control, high frequency isolation characteristic of the platform can be improved. The improvement effect is similar to increasing passive vibration reduction devices. Adopting the double closed loop control structure of velocity and current with the combining of the rejection effect of back-EMF caused by current loop is equivalent to reducing back-EMF coefficient, which can enhance the isolation ability of the LOS stabilization platform to high frequency disturbance.

  6. A MATLAB-Based Boundary Data Simulator for Studying the Resistivity Reconstruction Using Neighbouring Current Pattern

    OpenAIRE

    Tushar Kanti Bera; Nagaraju, J.

    2013-01-01

    Phantoms are essentially required to generate boundary data for studying the inverse solver performance in electrical impedance tomography (EIT). A MATLAB-based boundary data simulator (BDS) is developed to generate accurate boundary data using neighbouring current pattern for assessing the EIT inverse solvers. Domain diameter, inhomogeneity number, inhomogeneity geometry (shape, size, and position), background conductivity, and inhomogeneity conductivity are all set as BDS input variables. D...

  7. Transcranial direct current stimulation in refractory continuous spikes and waves during slow sleep: a controlled study

    DEFF Research Database (Denmark)

    Varga, Edina T; Terney, Daniella; Atkins, Mary D;

    2011-01-01

    Cathodal transcranial direct current stimulation (tDCS) decreases cortical excitability. The purpose of the study was to investigate whether cathodal tDCS could interrupt the continuous epileptiform activity. Five patients with focal, refractory continuous spikes and waves during slow sleep were...... recruited. Cathodal tDCS and sham stimulation were applied to the epileptic focus, before sleep (1 mA; 20 min). Cathodal tDCS did not reduce the spike-index in any of the patients....

  8. Counseling psychology and psychotherapy skills’ studies: current status in Western and Russian Psychology

    Directory of Open Access Journals (Sweden)

    Kryuchkov K.S.

    2015-10-01

    Full Text Available The article presents a brief review of studies concerning the current status of the psychotherapeutic and counseling skills in the West (mainly in the USA and in Russia. Papers written by the fellows of the leading US labs in this field and by other scientists are reviewed in this article alongside with investigations of several Russian psychological institutions. We also introduce some theoretical and methodological papers of Russian scholars

  9. Investigation of scaling properties of a thin current sheet by means of particle trajectories study

    CERN Document Server

    Sasunov, Yu L; Alexeev, I I; Belenkaya, E S; Semenov, V S; Kubyshkin, I V; Mingalev, O V

    2015-01-01

    A thin current sheet (TCS), with the width of an order of thermal proton gyroradius, appears a fundamental physical object which plays an important role in structuring of major magnetospheric current systems (magnetotail, magnetodisk, etc.). The TCSs are nowadays under extensive study by means of space missions and theoretical models. We consider a simple model of the TCS separating two half-spaces occupied by a homogenous magnetic field of opposite sign tangential to the TCS; a small normal component of the magnetic field is prescribed. An analytical solution for the electric current and plasma density in the close vicinity of the TCS has been obtained and compared with numerical simulation. The number density and the electric current profiles have two maxima each. The characteristic spatial scale $z_S$ of the maxima location was investigated as a function of initial pitch-angle of an incoming charge particle. The effect of the thermal dispersion of the incoming proton beam have been taken into consideration...

  10. Gaps exist in the current guidance on the use of randomized controlled trial study protocols in systematic reviews.

    Science.gov (United States)

    Boden, Catherine; Bidonde, Julia; Busch, Angela

    2017-05-01

    The use of trial registry records and randomized controlled trial (RCT) study protocols can assist systematic reviewers in evaluating and, possibly, minimizing publication and selective reporting biases. This study examined current guidance on the use of registry records and RCT study protocols from key systematic review organizations, institutes, and collaborations. Handbooks, guidelines, and standard documents from key systematic review organizations and the EQUATOR network database were identified. Textual excerpts providing guidance on the use of trial registry records, RCT protocols, and ongoing/unpublished studies were extracted independently by two reviewers and coded into a systematic review framework. Eleven documents published in English between 2009 and 2016 were included. Guidance for using RCT protocols and trial registry records was provided for 7 of 16 framework categories, and guidance for using unpublished and ongoing studies was available for 8 of 16 categories. This study identified gaps and ambiguities in language in guidance on the use of RCT protocols and trial registry records. To encourage and assist reviewers to use trial registry records and RCT study protocols in systematic reviews, current guidance should be expanded and clarified. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Study on Eddy-current of Disc Permanent-magnet Eddy-current Couplings%盘式永磁涡流耦合器涡流研究

    Institute of Scientific and Technical Information of China (English)

    上官璇峰; 杨帅

    2015-01-01

    本文旨在研究盘式涡流耦合器涡流分布特点。采用解析法得到了涡流密度的函数表达式;利用三维有限元法分别计算正常工作状态和起动状态下涡流径向分量和周向分量沿径向和周向分布的三维图形并总结涡流沿周向、径向、轴向的分布特点。根据涡流密度的函数表达式着重分析了导体盘材料、气隙长度和转差率三个重要因素对涡流的影响。通过对盘式永磁涡流耦合器涡流特点的把握,合理的解释了轴向磁力随转差率变化的规律。%The purpose of this paper is to study the changing discipline of eddy-current of disc permanent-magnet eddy-current coupling.Analytical method was adopted to get expression of the eddy-current density. 3D FEMwas adopted to obtain the 3D distribution graph along with radial and circumferential direction of eddy-current on radial and circumferential components.And the characteristics of distribution of eddy-current along with radial,circumferential and axial directions were summarized.Three important factors of the influence of eddy-current,conductor plate material,air-gap length and slip were analyzed according to the expression of eddy-current density.Through the grasp of the characteristics of eddy-current,the law of the axial magnetic force changing with slip was explained reasonably.

  12. A Snapshot Study of Current Practices among Sellers of Translation Services between Japanese and English

    Directory of Open Access Journals (Sweden)

    Dr. Stephen Crabbe

    2015-11-01

    Full Text Available A two-part study was launched in light of the Japan Translation Federation’s 2012 statement in its guide, 翻訳で失敗しないために翻訳発注の手引き [lit. For not getting it wrong with translation: a guide to ordering translation], that “外国語の文書を母国語に翻訳するのがプロの原則です” [lit. It is a fundamental principle that professional translators work into their native languages] (Japan Translation Federation, 2012, p. 15. The key goal is to gauge the extent to which this 2012 statement is reflected in current practices among the sellers and buyers of translation services between Japanese and English. In this paper, which describes the first part of the study, the focus is on the practices of sellers of translation services between Japanese and English: specifically, professional freelance translators. Twenty-four professional freelance translators completed an online questionnaire. The results of this questionnaire, first, suggest that current practices among sellers of translation services between Japanese and English are consistent with the Japan Translation Federation’s 2012 statement and, second, broadly support secondary literature on L1 translation (translation into the first language and L2 translation (translation into the second language. Whilst this is only a snapshot of current practices among sellers of translation services between Japanese and English, the overall results are informative. In the second, follow-up part of the study the focus will be on the current practices of buyers of translation services between Japanese and English.

  13. The relationship between attitudes towards menarche and current attitudes towards menstruation of women: A comparative study

    Directory of Open Access Journals (Sweden)

    Nülüfer Erbil

    2015-11-01

    Full Text Available Purpose: The study was conducted to determine affecting factors and to investigate relationship  between  attitudes towards menarche and current attitudes towards menstruation of women and to compare characteristics of menarche and menstruation of women who were born and raised in the northeastern and western of Turkey.  Method and Materials: This descriptive and comparative study was participated totally 400 volunteer women. The data were collected using a questionnaire containing defined closed and open-ended questions. Results: The study results showed that women living in Ordu province than women living in Aydın province expressed positive attitudes toward menarche, and the difference was found significant. Nevertheless, attitudes towards current menstruation were similar in both provinces. When the data of 400 women were evaluated together; women’s attitudes towards menarche were compared with the current attitudes towards menstruation, and the difference was found statistically significant. Although attitudes of the women towards menarche varied according to where they lived, their current attitudes towards menstruation were similar. In addition, depending upon the province, there were statistically significant differences in women’s age at menarche, recollection of menarche, and feelings of shame or happiness at menarche, source and adequacy of information about menstruation, and regularity of their menstrual cycle.   Conclusions: Early menstrual experiences may be related to menstrual experiences later in life and women’s attitudes towards menstruation were not affected by geographical locations. In order to develop positive attitudes towards menarche and a woman’s future years of menstrual cycles, it is very important that accurate and adequate information for young girls be provided before menarche.

  14. Empirical studies of magnetosheath and tail field and current structure, and model comparisons. Ph.D. Thesis

    Energy Technology Data Exchange (ETDEWEB)

    Kaymaz, Z.

    1993-12-31

    In this dissertation, the authors present the observational results obtained with IMP-8 in the magnetosheath and magnetotail, and compare them with the results from the gas dynamic (GD) and global magnetohydrodynamic (MHD) models. Although the magnetotail has been investigated by many others, the magnetosheath is one of the least studied regions of space despite its importance in solar wind-magnetosphere coupling. In this study, by utilizing a large magnetometer data set obtained simultaneously from IMP-8 and ISEE-3, the authors construct average magnetic field vector maps of the magnetosheath and tail in the cross-sectional plane. They determine how this average structure is influenced by the IMF, the Earth`s dipole tilt angle, and geomagnetic activity. For equatorial IMF`s, the magnetosheath field drapes asymmetrically around the magnetosphere causing a rotation of the field draping pattern, the tail current sheet twists, and plasma sheet field lines cease to show north-south symmetry. The magnetic field structure for north/south IMF`s is also shown to exhibit different properties including irregularities in the sheath (for southward) and placement of the dipolar and flaring regions in the tail. An IMF related perturbation field is observed in the tail which is strongest on the plasma sheet dawn and dusk sides for equatorial IMF, and on the flanks for north-south IMF. The Earth`s dipole tilt with respect to the geomagnetic equator affects the magnetotail current structure by causing its displacement from the geomagnetic equator. The authors examine the structure of the current sheet shape and location extensively using 16-years of IMP-8 magnetic field data. They show how geomagnetic activity affects this displacement. Many other field and current properties of the tail structure are also investigated such as the spatial distribution of the current density vectors and the (J x B) forces.

  15. Respiratory health effects of opencast coalmining: a cross sectional study of current workers.

    Science.gov (United States)

    Love, R G; Miller, B G; Groat, S K; Hagen, S; Cowie, H A; Johnston, P P; Hutchison, P A; Soutar, C A

    1997-06-01

    To identify whether there is evidence of pneumoconiosis and other respiratory health effects associated with exposure to respirable mixed dust and quartz in United Kingdom opencast coalmines. A cross sectional study of current workers (1224 men, 25 women) was carried out at nine large and medium sized opencast sites in England, Scotland, and Wales. To characterise a range of occupational groups within the industry, full shift measurements of personal exposures to respirable dust and quartz were taken. Up to three surveys were carried out at each site, covering all four seasons. For the purposes of comparisons with health indices these groups were further condensed into five broad combined occupational groups. Full sized chest radiographs, respiratory symptoms, occupational history questionnaires, and simple spirometry were used to characterise the respiratory health of the workforce. Logistic or multiple regression techniques were used to examine relations between indices of exposure and respiratory health. None of the group geometric mean dust concentrations, based on 626 valid dust samples, exceeded 1 mg.m-3, and 99% of all quartz concentrations were below 0.4 mg.m-3, the current maximum exposure limit. The highest quartz concentrations were experienced by the rock drilling team and drivers of bulldozers (used to move earth and stone from layers of coal). There were clear differences in mean respirable dust and quartz concentrations between occupational groups. These were consistent across the different sites, but depended in part on the day of measurement. The variations between sites were not much greater than between days, suggesting that differences between sites were at least partly explained by differences in conditions at the time of the measurements. The prevalence of radiographic small opacities profusion category > or = 1/0, based on the median of three readings, was 4.4%. Five men had category 2 pneumoconiosis and two men (including one of these five

  16. A study of current maintenance challenges in a large offshore wind farm

    DEFF Research Database (Denmark)

    Petersen, Kristian Rasmus; Madsen, Erik Skov; Bilberg, Arne

    The aim of the present research project is to obtain a better understanding of the operations and maintenance (O&M) processes that are performed in the offshore wind energy sector. So far, the focus on O&M of offshore wind parks has been very limited and is currently in its early phase. A compara...... used in this study is the case study method. We have followed a team of service-technicians for a longer period of time to investigate their work tasks. This has given an insight in how maintenance jobs are planned, carried out and....

  17. CRITICAL CURRENT AND JUNCTION BETWEEN PANCAKE STUDIES FOR HTS COIL DESIGN

    CERN Document Server

    Lécrevisse, Y; Louchart, O; Rey, J-M; Tixador, P

    2011-01-01

    YBCO Coated Conductor (CC) are very attractive for very high magnetic field coil with lower cryogenics need. We study two major aspects of HTS coil building. First the results of critical current measurements on YBCO tape provided by SuperPower are presented for a large temperature range and in parallel magnetic field configuration. A model is also proposed to extrapolate those measurements at other temperatures and fields. Then we focus on the critical aspect of junctions between pancakes. Junctions in cylindrical configuration are studied using three different soldering materials. The results are promising for further coil building.

  18. CFD Study of NACA 0018 for Diffuser Design of Tidal Current Turbines

    Directory of Open Access Journals (Sweden)

    Nasir Mehmood

    2012-11-01

    Full Text Available This study is focused on diffuser augmented tidal current turbines that capture the kinetic energy in a tidal stream. The energy that can be extracted from tides is proportional to the cube of the current velocity. The role of the diffuser in diffuser augmented tidal turbines is to help accelerate the incoming current velocity. Consequently, the efficiency of the turbine can be significantly increased by using a diffuser. The research community is investing considerable time and financial resources in this growing domain. The diffuser augmented tidal turbines research data is rather scarce due to their emerging nature, large and costly research and development setup, startup cost and proprietary issues. The purpose of this study is to investigate the effect of length and angle on NACA 0018 airfoil for diffuser design. CFD simulation is carried out to investigate velocity and mass flow rate at the throat. The drag force due to diffuser installation is also calculated. Velocity inside the diffuser increases with diffuser length and angle of attack. Velocity increases up to stall angle and then drops due to flow separation. The drag force is also dominant compared to lift coefficient near stall angle region.

  19. Affective bias and current, past and future adolescent depression: A familial high risk study

    Science.gov (United States)

    Kilford, Emma J.; Foulkes, Lucy; Potter, Robert; Collishaw, Stephan; Thapar, Anita; Rice, Frances

    2015-01-01

    Background Affective bias is a common feature of depressive disorder. However, a lack of longitudinal studies means that the temporal relationship between affective bias and depression is not well understood. One group where studies of affective bias may be particularly warranted is the adolescent offspring of depressed parents, given observations of high rates of depression and a severe and impairing course of disorder in this group. Methods A two wave panel design was used in which adolescent offspring of parents with recurrent depression completed a behavioural task assessing affective bias (The Affective Go/No Go Task) and a psychiatric interview. The affective processing of adolescents with current, prior and future depressive disorder was compared to that of adolescents free from disorder. Results Adolescents with current depression and those who developed depression at follow-up made more commission errors for sad than happy targets compared to adolescents free from disorder. There was no effect of prior depression on later affective processing. Limitations Small cell sizes meant we were unable to separately compare those with new onset and recurrent depressive disorder. Conclusions Valence-specific errors in behavioural inhibition index future vulnerability to depression in adolescents already at increased risk and may represent a measure of affective control. Currently depressed adolescents show a similar pattern of affective bias or deficits in affective control. PMID:25527997

  20. Current practice in continuous renal replacement therapy: An epidemiological multicenter study.

    Science.gov (United States)

    Tomasa Irriguible, T M; Sabater Riera, J; Poch López de Briñas, E; Fort Ros, J; Lloret Cora, M J; Roca Antònio, J; Navas Pérez, A; Ortiz Ballujera, P; Servià Goixart, L; González de Molina Ortiz, F J; Rovira Anglès, C; Rodríguez López, M; Roglan Piqueras, A

    2017-05-01

    The aim of the study is to ascertain the most relevant aspects of the current management of renal replacement therapy (RRT) in critically ill patients, and to analyze renal function recovery and mortality in patients undergoing RRT. A non-interventional three-month observational study was made in 2012, with a follow-up period of 90 days, in 21 centers in Catalonia (Spain). Demographic information, severity scores and clinical data were obtained, as well as RRT parameters. patients aged ≥ 16 years admitted to Intensive Care Units (ICUs) and subjected to RRT. A total of 261 critically ill patients were recruited, of which 35% had renal dysfunction prior to admission. The main reason for starting RRT was oliguria; the most widely used RRT modality was hemodiafiltration; and the median prescribed dose at baseline was 35mL/kg/h. The median time of RRT onset from ICU admission was one day. The mortality rate at 30 and 90 days was 46% and 54%, respectively, and was associated to greater severity scores and a later onset of RRT. At discharge, 85% of the survivors had recovered renal function. Current practice in RRT in Catalonia abides with the current clinical practice guidelines. Mortality related to RRT is associated to later onset of such therapy. The renal function recovery rate at hospital discharge was 85% among the patients subjected to RRT. Copyright © 2016 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

  1. Rayleigh wave modeling: A study of dispersion curve sensitivity and methodology for calculating an initial model to be included in an inversion algorithm

    Science.gov (United States)

    de Lucena, Rodrigo F.; Taioli, Fabio

    2014-09-01

    This paper presents a study on Rayleigh wave modeling. After model implementation using Matlab software, unpublished studies were conducted of dispersion curve sensitivity to percentage changes in parameter values, including S- and P-wave velocities, substrate density, and layer thickness. The study of the sensitivity of dispersion curves demonstrated that parameters such as S-wave velocity and layer thickness cannot be ignored as inversion parameters, while P-wave velocity and density can be considered as known parameters since their influence is minimal. However, the results showed limitations that should be considered and overcome when choosing the known and unknown parameters through determining a good initial model or/and by gathering a priori information. A methodology considering the sensitivity study of dispersion curves was developed and evaluated to generate initial values (initial model) to be included in the local search inversion algorithm, clearly establishing initial favorable conditions for data inversion.

  2. Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial.

    Science.gov (United States)

    Arenaza, Lide; Medrano, María; Amasene, María; Rodríguez-Vigil, Beatriz; Díez, Ignacio; Graña, Manuel; Tobalina, Ignacio; Maiz, Edurne; Arteche, Edurne; Larrarte, Eider; Huybrechts, Inge; Davis, Catherine L; Ruiz, Jonatan R; Ortega, Francisco B; Margareto, Javier; Labayen, Idoia

    2017-08-10

    The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes (T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention program, including supervised exercise, on insulin resistance syndrome (IRS) risk in children with a high risk of developing T2D and (2) to identify the profile of microRNA in circulating exosomes and in peripheral blood mononuclear cells in children with a high risk of developing T2D and its response to a multidisciplinary intervention program including exercise. A total of 84 children, aged 8-12 years, with a high risk of T2D will be included and randomly assigned to control (N = 42) or intervention (N = 42) groups. The control group will receive a family based lifestyle education and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week, 90 min per session including warm-up, moderate to vigorous aerobic activities, and strength exercises). The following measurements will be evaluated at baseline prior to randomization and after the intervention: fasting insulin, glucose and hemoglobin A1c; body composition (dual-energy X-ray absorptiometry); ectopic fat (magnetic resonance imaging); microRNA expression in circulating exosomes and in peripheral blood mononuclear cells (MiSeq; Illumina); cardiorespiratory fitness (cardiopulmonary exercise testing); dietary habits and physical activity (accelerometry). Prevention and identification of children with a high risk of developing T2D could help to improve their cardiovascular health and to reduce the comorbidities associated with obesity. ClinicalTrials.gov, ID: NCT03027726 . Registered on 16 January 2017.

  3. The current status of structural studies on proteins of the myelin sheath (Review).

    Science.gov (United States)

    Kursula, P

    2001-11-01

    Myelin, the multilayered membrane structure surrounding axons, provides a unique environment to its proteins, which are either transmembrane proteins or interacting intimately with the membrane surface. Although myelin-specific proteins have been studied for decades, remarkably little is known of their three-dimensional structures. In addition, the exact functions of myelin proteins are to a large extent unknown. In this report, our current knowledge of peripheral nervous system myelin protein structures is reviewed, and the current status of attempts to solve the structures of full-length myelin proteins is evaluated. Furthermore, molecular models for the extracellular domain of the myelin-associated glycoprotein and the putative kinase-like domain of 2',3'-cyclic nucleotide 3'-phosphodiesterase are presented and discussed.

  4. Parametric study of rectangular coil for Eddy Current Testing of lamination

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Peng Fei; Zeng, Zhi Wei [School of Aerospace Engineering, Xiamen University, Xiamen (China)

    2016-04-15

    Eddy current testing (ECT) is an important nondestructive testing technology for the inspection of flaws in conductive materials. However, this widely used technology is not suitable for inspecting lamination when a conventional pancake coil is used because the eddy current (EC) generated by the pancake coil is parallel to the lamination and will not be perturbed. A new method using a rectangular coil placed vertical to the work piece is proposed for lamination detection. The vertical sections of the rectangular coil induce ECs that are vertical to the lamination and can be perturbed by the lamination. A parametric study of a rectangular coil by finite element analysis was performed in order to examine the capability of generating vertical EC sent data 1221-1237.

  5. A Study of Current Land Use in the Urban Area of Ma’anshan City

    Institute of Scientific and Technical Information of China (English)

    Ning ZHANG; Zhongxiang YU

    2016-01-01

    With the acceleration of urbanization,urban development poses a growing demand for land.China’s national conditions of a large population with relatively little arable land require us to intensively use land,and more and more departments have been aware of the importance of intensive urban land use.The study on the current land use in the urban area of Ma’anshan City,is not only conducive to adjustment of land use layout and structure as well as urban ecological construction,but also of guiding significance to the economical and intensive land use in Ma’anshan City.This paper first describes the natural,social and economic situation of Ma’anshan’s urban area,then analyzes the land use structure,layout and problems,and finally puts forth the recommendations for improving current land use situation in the urban area of Ma’anshan City.

  6. A study on the interference effects for tidal current power rotors

    Institute of Scientific and Technical Information of China (English)

    Chul-Hee; JO; Kang-Hee; LEE; Jin-Young; YIM

    2010-01-01

    Due to global warming, the need to secure an alternative resource has become more important nationally. With the high tidal range of up to 9.7 m on the west coast of Korea, numerous tidal current projects are being planned and constructed. To extract a significant quantity of power, a tidal current farm with a multi-arrangement is necessary in the ocean. The rotor, which initially converts the energy, is a very important component because it affects the efficiency of the entire system, and its performance is determined by various design variables. The power generation is strongly dependent on the size of the rotor and the incoming flow velocity. However, the interactions between devices also contribute significantly to the total power capacity. Therefore, rotor performance considering the interaction problems needs to be investigated for generating maximum power in a specific field. This paper documents a performance study of devices considering the interference between rotating rotors with axial, transverse and diagonal arrangements.

  7. Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease

    NARCIS (Netherlands)

    Collaborative Group on Hormona, l Factors; van den Brandt, P.A.; Goldbohm, R.A.

    2001-01-01

    Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Collaborative Group on Hormonal Factors in Breast Cancer. BACKGROUND: Women with a family history of breast cancer are

  8. Study Modules for Calculus-Based General Physics. [Includes Modules 35-37: Reflection and Refraction; Electric Fields and Potentials from Continuous Charge Distributions; and Maxwell's Predictions].

    Science.gov (United States)

    Fuller, Robert G., Ed.; And Others

    This is part of a series of 42 Calculus Based Physics (CBP) modules totaling about 1,000 pages. The modules include study guides, practice tests, and mastery tests for a full-year individualized course in calculus-based physics based on the Personalized System of Instruction (PSI). The units are not intended to be used without outside materials;…

  9. Study Modules for Calculus-Based General Physics. [Includes Modules 31-34: Inductance; Wave Properties of Light; Interference; and Introduction to Quantum Physics].

    Science.gov (United States)

    Fuller, Robert G., Ed.; And Others

    This is Part of a series of 41 Calculus Based Physics (CBP) modules totaling about 1,000 Pages. The modules include study guides, practice tests, and mastery tests for a full-year individualized courses in calculus-based physics based on the Personalized System of Instruction (PSI). The units are not intended to be used without outside materials;…

  10. Pulmonary response to surface‐coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: A toxicogenomic study

    DEFF Research Database (Denmark)

    Halappanavar, Sabina; Jackson, Petra; Williams, Andrew

    2011-01-01

    Titanium dioxide nanoparticles (nanoTiO2) are used in various applications including in paints. NanoTiO2 inhalation may induce pulmonary toxicity and systemic effects. However, the underlying molecular mechanisms are poorly understood. In this study, the effects of inhaled surface‐coated nanoTiO2...

  11. Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease

    NARCIS (Netherlands)

    Collaborative Group on Hormona, l Factors; van den Brandt, P.A.; Goldbohm, R.A.

    2001-01-01

    Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Collaborative Group on Hormonal Factors in Breast Cancer. BACKGROUND: Women with a family history of breast cancer are

  12. Study Modules for Calculus-Based General Physics. [Includes Modules 21-23: Second Law and Entropy; Coulomb's Law and the Electric Field; and Flux and Gauss' Law].

    Science.gov (United States)

    Fuller, Robert G., Ed.; And Others

    This is part of a series of 42 Calculus Based Physics (CBP) modules totaling about 1,000 pages. The modules include study guides, practice tests, and mastery tests for a full-year individualized course in calculus-based physics based on the Personalized System of Instruction (PSI). The units are not intended to be used without outside materials;…

  13. Study Modules for Calculus-Based General Physics. [Includes Modules 18-20: Sound; Temperature, Heat, and Thermodynamics: First Law; and Kinetic Theory of Gases].

    Science.gov (United States)

    Fuller, Robert G., Ed.; And Others

    This is part of a series of 42 Calculus Based Physics (CBP) modules totaling about 1,000 pages. The modules include study guides, practice tests, and mastery tests for a full-year individualized course in calculus-based physics based on the Personalized System of Instruction (PSI). The units are not intended to be used without outside materials;…

  14. Study Modules for Calculus-Based General Physics. [Includes Modules 11-14: Collisions; Equilibrium of Rigid Bodies; Rotational Dynamics; and Fluid Mechanics].

    Science.gov (United States)

    Fuller, Robert G., Ed.; And Others

    This is part of a series of 42 Calculus Based Physics (CBP) modules totaling about 1,000 pages. The modules include study guides, practice tests, and mastery tests for a full-year individualized course in calculus-based physics based on the Personalized System of Instruction (PSI). The units are not intended to be used without outside materials;…

  15. Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines

    Directory of Open Access Journals (Sweden)

    Holder Roger L

    2009-07-01

    Full Text Available Abstract Background Multiple imputation (MI provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed datasets are each analysed using standard prognostic modelling techniques to obtain the estimates of interest. The estimates from each imputed dataset are then combined into one overall estimate and variance, incorporating both the within and between imputation variability. Rubin's rules for combining these multiply imputed estimates are based on asymptotic theory. The resulting combined estimates may be more accurate if the posterior distribution of the population parameter of interest is better approximated by the normal distribution. However, the normality assumption may not be appropriate for all the parameters of interest when analysing prognostic modelling studies, such as predicted survival probabilities and model performance measures. Methods Guidelines for combining the estimates of interest when analysing prognostic modelling studies are provided. A literature review is performed to identify current practice for combining such estimates in prognostic modelling studies. Results Methods for combining all reported estimates after MI were not well reported in the current literature. Rubin's rules without applying any transformations were the standard approach used, when any method was stated. Conclusion The proposed simple guidelines for combining estimates after MI may lead to a wider and more appropriate use of MI in future prognostic modelling studies.

  16. Occupational toxicology in Mexico: current status and the potential use of molecular studies to evaluate chemical exposure.

    Science.gov (United States)

    Muñoz, Balam; Albores, Arnulfo

    2011-11-01

    Occupational toxicology is of considerable concern for several world organizations including the International Labour Organization, the World Health Organization and the International Commission for Occupational Health and, in Latin America, the Pan American Health Organization. The countries of this Region, including Mexico, own manufacturing, chemical, and petrochemical industries that employ thousands workers who are continually exposed to hazardous chemicals such as solvents, particles and exhaust fumes, many of which are very complex mixtures. Traditionally, physicians have used biochemical analyses to assess the damage caused by chronic chemical exposure. Presently, recent advances in molecular biology may offer tools to perform more thorough and precise evaluations on worker health damage, risk and current health status. In this review, we present a perspective of occupational toxicology in Mexico, as an example for Latin America and developing countries. Moreover, we summarize current reports about occupational disease associated with chemical exposure, and we present an array of molecular studies proposed for the analysis and diagnosis of workers related with industry and the relevance of including molecular biology testing to complement traditional occupational medical assays in order to improve occupational health. We conclude that developing countries, e.g., Mexico, should improve work environment standards by using new technical approaches that will result in more reliable and precise data to design better health policy strategies.

  17. The association between current low-dose oral contraceptive pills and periodontal health: a matched-case-control study.

    Science.gov (United States)

    Haerian-Ardakani, Ahmad; Moeintaghavi, Amir; Talebi-Ardakani, Mahammadreza Reza; Sohrabi, Keyvan; Bahmani, Shahin; Dargahi, Maede

    2010-05-01

    This study assessed the influence of current oral contraceptive pills on periodontal health in young females. Seventy women ranging in age from 17 to 35 years (mean 24 years) had a comprehensive periodontal examination. Their current and previous oral contraceptive pill use was assessed by a questionnaire. A periodontal assessment was performed that included recording the following: plaque index, gingival index, probing depth, and attachment level at six sites per tooth. The periodontal health of women taking birth control pills for at least two years was compared to that of women not taking an oral contraceptive. The control and test groups were matched for socioeconomic status, age, oral habits, occupation, and educational levels. Although there was no difference in plaque index levels between the two groups, current oral contraceptive pill users had higher levels of gingival inflammation and bleeding on probing. However, no significant differences were found regarding mean probing depths and attachment loss between the two groups. As birth control policies are advocated by most countries, and because oral contraceptives are the most widely used method for birth control, a need exists to assess the effects of oral contraceptives on the periodontal health of young women. Although additional studies are needed to better understand the mechanism of OC-induced gingivitis, female patients should be informed of the oral and periodontal side effects of OCs and the need for meticulous home care and compliance with periodontal maintenance.

  18. Applications and limitations of thermobarometry in migmatites and granulites using as an example rocks of the Araçuaí Orogen in southern Bahia, including a discussion on the tectonic meaning of the current results

    Directory of Open Access Journals (Sweden)

    Renato Moraes

    Full Text Available In southern Bahia, there are outcrops of migmatites and granulites in the Jequitinhonha Complex, which is part of the northern portion of the Araçuaí Orogen. Migmatites (garnet-cordierite diatexite dominate the metamorphic rocks and host lenses and layers of felsic garnet granulite. The conditions of temperature and pressure of metamorphism were calculated using conventional thermobarometry and the software THERMOCALC. Values around 850 °C and 7 kbar were obtained with THERMOCALC. The calculations for the garnet-cordierite diatexite were made considering aH2O equal to 1, but the best results of calculations for the granulites are obtained with aH2O values of 0.3. Pressure values obtained with GAPES resulted in consistent values with THERMOCALC, but the pair garnet-orthopyroxene always produces low values for temperature and high ones for pressure. The results are consistent with the presence of the pair garnet and cordierite in diatexite and orthopyroxene in felsic granulite. From the tectonic point of view, the setting in which metamorphism of these rocks occurred requires high heat flow with a thermal anomaly in mid continental crust, as indicated by values of 7 kbar. Recent studies have favored the closure of a back-arc basin for this tectonic setting, but it does not solve the problem that the time span between metamorphic peak and the end of granite intrusions, involving large bodies of charnockite, is more than 80 million years. The model of tectonic switching is suggested here as it can explain the maintenance of high temperatures for a more extended interval of time.

  19. Issues Relating to Study Design and Risk of Bias When Including Non-Randomized Studies in Systematic Reviews on the Effects of Interventions

    Science.gov (United States)

    Higgins, Julian P. T.; Ramsay, Craig; Reeves, Barnaby C.; Deeks, Jonathan J.; Shea, Beverley; Valentine, Jeffrey C.; Tugwell, Peter; Wells, George

    2013-01-01

    Non-randomized studies may provide valuable evidence on the effects of interventions. They are the main source of evidence on the intended effects of some types of interventions and often provide the only evidence about the effects of interventions on long-term outcomes, rare events or adverse effects. Therefore, systematic reviews on the effects…

  20. Clinical and experimental studies on polyherbal formulations for diabetes:current status and future prospective

    Institute of Scientific and Technical Information of China (English)

    Ahmad Ghorbani

    2014-01-01

    Diabetes is a leading cause of morbidity and mortality in the world. There is currently an active search for antidiabetic drugs with greater effectiveness with fewer and less adverse side effects. Although numerous individual herbs have been experimentally or clinically reported to possess antidiabetic effects, considerably less research has been conducted on polyherbal compounds. It is believed that herbal compounds containing multiple plant products have synergistic antidiabetic effects and could enhance the desired actions. Several polyherbal formulations have been studied as therapeutic agents in diabetes management. To describe the current state of research on polyherbal compounds in the treatment of diabetes, an extensive review of literature was undertaken on several major databases. This paper presents what is known about the efifcacy of these polyherbal formulations and compare their antidiabetic effects with those of current oral hypoglycemic drugs as reference. The percent decrease in blood glucose, lipids and other biochemical parameters achieved by each product in diabetic animals and patients is reported. Also, the possible mechanisms responsible for hypoglycemic action of polyherbal formulations are discussed.

  1. A Practical Study of the 66kV Fault Current Limiter (FCL) System with Rectifier

    Science.gov (United States)

    Tokuda, Noriaki; Matsubara, Yoshio; Yuguchi, Kyosuke; Ohkuma, Takeshi; Hobara, Natsuro; Takahashi, Yoshihisa

    A fault current limiter (FCL) is extensively expected to suppress fault current, particularly required for trunk power systems heavily connected high-voltage transmission lines, such as 500kV class power system which constitutes the nucleus of the electric power system. By installing such FCL in the power system, the system interconnection is possible without the need to raise the capacity of the circuit breakers, and facilities can be configured for efficiency, among other benefits. For these reasons, fault current limiters based on various principles of operation have been developed both in Japan and abroad. In this paper, we have proposed a new type of FCL system, consisting of solid-state diodes, DC coil and bypass AC coil, and described the specification of distribution power system and 66kV model at the island power system and the superconducting cable power system. Also we have made a practical study of 66kV class, which is the testing items and the future subjects of the rectifier type FCL system.

  2. Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls

    DEFF Research Database (Denmark)

    Cancer, Collaborative Group on Epidemiological Studies of Ovarian; Beral, V.; Doll, R.

    2008-01-01

    BACKGROUND: Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We...... aimed to assess these effects. METHODS: Individual data for 23,257 women with ovarian cancer (cases) and 87,303 without ovarian cancer (controls) from 45 epidemiological studies in 21 countries were checked and analysed centrally. The relative risk of ovarian cancer in relation to oral contraceptive use...... was estimated, stratifying by study, age, parity, and hysterectomy. FINDINGS: Overall 7308 (31%) cases and 32,717 (37%) controls had ever used oral contraceptives, for average durations among users of 4.4 and 5.0 years, respectively. The median year of cancer diagnosis was 1993, when cases were aged an average...

  3. 微小 RNA 在朊病毒病等神经退行性疾病中的研究进展%Current research progress on microRNAs in neurodegenerative diseases including prion diseases

    Institute of Scientific and Technical Information of China (English)

    魏静; 高晨

    2016-01-01

    朊病毒病是一类具有传染性、不可逆且致命的神经退行性疾病,其致病机制为体内正常编码的细胞型朊蛋白(cellular prion protein ,PrPC )构象发生变化,形成了具有感染性的异常痒病型朊病毒(scrapie prion protein ,PrPSc ),但具体机制不清楚,目前为止尚无有效治疗方法。微小 RNA(microRNA ,miRNA)可在转录水平调控细胞蛋白表达,对神经系统发育及功能起重要作用。近年来,对一些特定miRNA在朊病毒病中相应调控机制、自发免疫、炎症信号转导及靶基因预测方面的研究可为治疗朊病毒病提供新的角度。本文就miRNA在朊病毒病发生中的相关研究进展进行综述,并详细探讨其中研究较为深入的miRNA。%Transmissible spongiform encephalopathies (TSEs) ,or prion diseases ,are irreversible and fatal neurodegenerative disorders associated with the conformational conversion of cellular prion protein (PrPC ) , a normal cellular protein ,into scrapie prion protein (PrPSc ) ,a structural isoform that is infectious and with no effective treatment yet .MicroRNA can regulate cellular protein expression at transcriptional level and may play an critical role in the development process of central nervous system .Recent studies indicate that some specific microRNAs involved in the regulation of innate immune response and inflammation signaling pathways may also be implicated in prion diseases and provide some new insights into the treatment of prion diseases .This review highlights the progress on microRNAs in the occurrence of prion diseases and discusses the leading microRNAs in detail .

  4. MSE measurements for sawtooth and non-inductive current drive studies in KSTAR

    Science.gov (United States)

    Ko, J.; Park, H.; Bea, Y. S.; Chung, J.; Jeon, Y. M.

    2016-10-01

    Two major topics where the measurement of the magnetic-field-line rotational transform profiles in toroidal plasma systems include the long-standing issue of complete versus incomplete reconnection model of the sawtooth instability and the issue with future reactor-relevant tokamak devices in which non-inductive steady state current sustainment is essential. The motional Stark effect (MSE) diagnostic based on the photoelastic-modulator (PEM) approach is one of the most reliable means to measure the internal magnetic pitch, and thus the rotational transform, or its reciprocal (q), profiles. The MSE system has been commissioned for the Korea Superconducting Tokamak Advanced Research (KSTAR) along with the development of various techniques to minimize systematic offset errors such as Faraday rotation and mis-alignment of the bandpass filters. The diagnostic has revealed the central q is well correlated with the sawtooth oscillation, maintaining its value above unity during the MHD quiescent period and that the response of the q profile to external current drive such as electron cyclotron wave injection not only involves the local change of the pitch angle gradient but also a significant shift of the magnetic topology due to the wave energy transport. Work supported by the Ministry of Science, ICT and Future Planning, Korea.

  5. NUMERICAL STUDY ON THE FORMATION OF THE SOUTH CHINA SEA WARM CURRENT Ⅱ. BAROCLINIC CASE

    Institute of Scientific and Technical Information of China (English)

    王凯; 方国洪; 施心慧

    2001-01-01

    In this part, Levitus' climatological temperature and salinity are incorporated in the numerical model developed in Part I. Diagnostic and prognostic experiment on the thermohaline circulation were conducted. The smooth Levitus' data do not include any information on the South China Sea Warm Current (SCSWC), so it is not in the model-produced diagnostic thermohaline circulation. Although the SCSWC does not appear in the wind-driven circulation in the barotropic case, it appears in the prognostic wind-driven circulation in the baroclinic case. This implies that the differing circulation pat-terns between barotropic case and bareclinic case are due to the stratification. The prognostic thermohaline circulation with wind stress and inflow/outflow transports at open boundaries are also discussed. Coupling of density and dynamic forces makes the circulation pattern more complicated, Even though the stratification is not always a direct cause of the formation of the SCSWC, it is at least an indirect cause.

  6. NUMERICAL STUDY ON THE FORMATION OF THE SOUTH CHINA SEA WARM CURRENT II. BAROCLINIC CASE

    Institute of Scientific and Technical Information of China (English)

    王凯; 方国洪; 施心慧

    2001-01-01

    In this part, Levitus' climatological temperature and salinity are incorporated in the numerical model developed in Part I. Diagnostic and prognostic experiment on the thermohaline circulation were conducted. The smooth Levitus' data do not include any information on the South China Sea Warm Current (SCSWC), so it is not in the model-produced diagnostic thermohaline circulation. Although the SCSWC does not appear in the wind-driven circulation in the barotropic case, it appears in the prognostic wind-driven circulation in the baroclinic case. This implies that the differing circulation patterns between barotropic case and baroclinic case are due to the stratification. The prognostic thermohaline circulation with wind stress and inflow/outflow transports at open boundaries are also discussed. Coupling of density and dynamic forces makes the circulation pattern more complicated. Even though the stratification is not always a direct cause of the formation of the SCSWC, it is at least an indirect cause.``

  7. Motivated Attention to Cocaine and Emotional Cues in Abstinent and Current Cocaine Users: An ERP Study

    Science.gov (United States)

    Dunning, Jonathan P.; Parvaz, Muhammad A.; Hajcak, Greg; Maloney, Thomas; Alia-Klein, Nelly; Woicik, Patricia A.; Telang, Frank; Wang, Gene-Jack; Volkow, Nora D.; Goldstein, Rita Z.

    2011-01-01

    Event-related potentials (ERPs) are a direct measure of neural activity and are ideally suited to study the time-course of attentional engagement with emotional and drug-related stimuli in addiction. In particular, the late positive potential (LPP) appears enhanced following cocaine-related compared to neutral stimuli in individuals with cocaine use disorders (CUD). However, previous studies have not directly compared cocaine-related to emotional stimuli while examining potential differences between abstinent and current cocaine users. The present study examined ERPs in 55 CUD (27 abstinent and 28 current users) and 29 matched healthy controls while they passively viewed pleasant, unpleasant, neutral, and cocaine-related pictures. To examine the time-course of attention to these stimuli, we analyzed both an early and later window in the LPP as well as the early posterior negativity (EPN), established in assessing motivated attention. Cocaine pictures elicited increased electrocortical measures of motivated attention in ways similar to affectively pleasant and unpleasant pictures in all CUD, an effect that was no longer discernible during the late LPP window for the current users. This group also exhibited deficient processing of the other emotional stimuli (early LPP window: pleasant pictures; late LPP window: pleasant and unpleasant pictures). Results were unique to the LPP and not EPN. Taken together, results support a relatively early attention bias to cocaine stimuli in cocaine addicted individuals further suggesting that recent cocaine use decreases such attention bias during later stages of processing but at the expense of deficient processing of other emotional stimuli. PMID:21450043

  8. Admittance Modeling of Voltage and Current Controlled Inverter for Harmonic Instability Studies

    DEFF Research Database (Denmark)

    Hoseinzadeh, Bakhtyar; Bak, Claus Leth

    2016-01-01

    This paper proposes an impedance/admittance based model for voltage and current controlled inverters with passive elements suitable for harmonic instability study of grid connected inverters in frequency domain. This linearized model of inverters, significantly simplifies investigation of resonance...... instability and control loop interaction of wind turbines with each other and/or with the grid, while they are installed in wind farms. The derived impedance ratio at point of common connection demonstrates how the inverters participate in harmonic stability of the grid....

  9. [Current quality management situation and administration countermeasure study of enterprises marketing corneal contact lens].

    Science.gov (United States)

    Liu, Yungui; Yao, Ying; Shangguan, Shihao; Gu, Qun; Gao, Wuming; Chen, Yaoshui

    2014-05-01

    Study the current quality management situation of enterprises marketing corneal contact lens via systemic investigations and explore effective administration countermeasures in the future. The quality management indicators of sixty-two corneal contact lens marketing enterprises in Xuhui district of Shanghai were systematically investigated and enterprises of different operation models was compared and analyzed. Wholesale enterprises and retail chain enterprises are apparently better than independent enterprises almost in all facets. Facilitate market accession of corneal contact lens marketing enterprises, encourage the business model of retail chain, enhance supervision of corneal contact lens marketing enterprises, especially independent franchisors.

  10. Electromagnetic and beam dynamics studies of a high current drift tube linac for LEHIPA

    Science.gov (United States)

    Roy, S.; Rao, S. V. L. S.; Pande, R.; Krishnagopal, S.; Singh, P.

    2014-06-01

    We have performed detailed electromagnetic and beam dynamics studies of a 352.21 MHz drift-tube linac (DTL) that will accelerate a 30 mA CW proton beam from 3 to 20 MeV. At such high currents space charge effects are important, and therefore the effect of linear as well as non-linear space charge has been studied (corresponding to uniform and Gaussian initial beam distributions), in order to avoid space charge instabilities. To validate the electromagnetic simulations, a 1.2 m long prototype of the DTL was fabricated. RF measurements performed on the prototype were in good agreement with the simulations. A detailed simulation study of beam halos was also performed, which showed that beyond a current of 10 mA, significant longitudinal beam halos are excited even for a perfectly matched beam, whereas for a mis-matched beam transverse beam halos are also excited. However, these do not lead to any beam loss within the DTL.

  11. Study of a new direct current atmospheric pressure glow discharge in helium

    Energy Technology Data Exchange (ETDEWEB)

    Gielniak, B. [University of Hamburg, Institute for Inorganic and Applied Chemistry, Martin-Luther-King-Platz 6, 20146 Hamburg (Germany); Fiedler, T. [Johannes Gutenberg-University Mainz, Institute for Inorganic and Analytical Chemistry, Duesbergweg 10-14, 55128 Mainz (Germany); Broekaert, J.A.C., E-mail: jose.broekaert@chemie.uni-hamburg.de [University of Hamburg, Institute for Inorganic and Applied Chemistry, Martin-Luther-King-Platz 6, 20146 Hamburg (Germany)

    2011-01-15

    In this study a new DC-APGD operated in He was developed and characterized. The discharge is operated at 0.9 kV and about 25-35 mA and at a gas flow of 100 ml/min. The source was spectroscopically studied and parameters such as the rotational temperature (T{sub rot}), the excitation temperature (T{sub exc}), the ionization temperature (T{sub ion}) and the electron number density (n{sub e}) were determined. The current-voltage characteristic of the source was studied as well. At optimized conditions the discharge operates in the normal region of the current-voltage characteristic. Rotational and excitation temperatures determined with the use of OH band and Fe I lines as thermometric species were of the order of about 900-1200 and 4500-5500 K, respectively. This indicates that despite of the atmospheric pressure, the discharge is not in LTE. Spatially resolved temperature measurements were performed with axial as well as radial resolution and showed relatively flat profiles. Axially resolved emission intensity profiles for several species such as H, N{sub 2}, N{sub 2}{sup +}, OH, He and Hg were determined. It also was found that H{sub 2} introduced into the He by electrolysis of acid solutions such as in ECHG considerably increases the spectroscopically measured gas temperatures but decreases the analyte line intensities, as shown for Hg.

  12. Selected Theoretical Studies Group contributions to the 14th International Cosmic Ray conference. [including studies on galactic molecular hydrogen, interstellar reddening, and on the origin of cosmic rays

    Science.gov (United States)

    1975-01-01

    The galactic distribution of H2 was studied through gamma radiation and through X-ray, optical, and infrared absorption measurements from SAS-2 and other sources. A comparison of the latitude distribution of gamma-ray intensity with reddening data shows reddening data to give the best estimate of interstellar gas in the solar vicinity. The distribution of galactic cosmic ray nucleons was determined and appears to be identical to the supernova remnant distribution. Interactions between ultrahigh energy cosmic-ray nuclei and intergalactic photon radiation fields were calculated, using the Monte Carlo method.

  13. Educational Management and Administration in Moray House College of Education. Teaching and Study: Current Developments

    Science.gov (United States)

    McIntosh, Douglas M.

    1972-01-01

    A Department of Educational Management and Administration was set up in May, 1968, which has been arranging inservice study groups on various aspects of school administration. One of its particular concerns is timetabling, including the most efficient use of teaching time and space. An Advisory Service is maintained for those individual…

  14. A Study of Current and Desired State of Physics Education in Iranian Female Secondary Schools

    Science.gov (United States)

    Liaghatdar, Mohammad J.; Soltani, Asghar; Shojaei, Rashin; Siadat, Ali

    2012-01-01

    This study has examined the characteristics of physics teachers, their professional competences, supplies of equipments and technologies, appropriate textbooks and motivational factors in students' learning of physics from female physics teacher's points of view. The population included all female physics teachers in Isfahan city and a total of 88…

  15. Optical modulator including grapene

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  16. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

    OpenAIRE

    Randall, J. C.; Winkler, T.W.; Kutalik, Z.; Berndt, S.I.; Jackson, A.U.; Monda, K.L.; Kilpelainen, T.O.; Esko, T; Magi, R.; Li, S.; Workalemahu, T; Feitosa,M. F.; Croteau-Chonka, D.C.; Day, F. R.; Fall, T.

    2013-01-01

    Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previousl...

  17. Determiners of enterprise risk management applications in Turkey: An empirical study with logistic regression model on the companies included in ISE (Istanbul Stock Exchange)

    OpenAIRE

    Şerife Önder; Hüseyin Ergin

    2012-01-01

    Enterprise risk management (ERM), which came along with the change in the understanding of risk management in companies, refers to evaluation of all the risks as a whole and managing them in line with the targets of the company. This study aims at determining the ERM application levels of the companies included in the Istanbul Stock Exchange and the factors that affect these applications. Existence of ERM in the companies was related with having senior manager in charge of risk management. In...

  18. Ion Current Density Study of the NASA-300M and NASA-457Mv2 Hall Thrusters

    Science.gov (United States)

    Huang, Wensheng; Shastry, Rohit; Herman, Daniel A.; Soulas, George C.; Kamhawi, Hani

    2012-01-01

    NASA Glenn Research Center is developing a Hall thruster in the 15-50 kW range to support future NASA missions. As a part of the process, the performance and plume characteristics of the NASA-300M, a 20-kW Hall thruster, and the NASA-457Mv2, a 50-kW Hall thruster, were evaluated. The collected data will be used to improve the fidelity of the JPL modeling tool, Hall2De, which will then be used to aid the design of the 15-50 kW Hall thruster. This paper gives a detailed overview of the Faraday probe portion of the plume characterization study. The Faraday probe in this study is a near-field probe swept radially at many axial locations downstream of the thruster exit plane. Threshold-based integration limits with threshold values of 1/e, 1/e(sup 2), and 1/e(sup 3) times the local peak current density are tried for the purpose of ion current integration and divergence angle calculation. The NASA-300M is operated at 7 conditions and the NASA-457Mv2 at 14 conditions. These conditions span discharge voltages of 200 to 500 V and discharge power of 10 to 50 kW. The ion current density profiles of the near-field plume originating from the discharge channel are discovered to strongly resemble Gaussian distributions. A novel analysis approach involving a form of ray tracing is used to determine an effective point of origin for the near-field plume. In the process of performing this analysis, definitive evidence is discovered that showed the near-field plume is bending towards the thruster centerline.

  19. Surface Currents. Southwest North Pacific Ocean Including the Philippine Islands.

    Science.gov (United States)

    1977-07-01

    020’ a * 0*" *20 2*’ 20 .042 220’ 2*’ 200’ 2*2 2202 *2 2002 *02 2002 22022200 S 202’ 220’ 0*2 2022 0*’ 022’ ~52 0*2 02 000 2 p~2 2002 a’ o2o ~ .0 02 02

  20. Visual Impairment, Including Blindness

    Science.gov (United States)

    ... Who Knows What? Survey Item Bank Search for: Visual Impairment, Including Blindness Links updated, April 2017 En ... doesn’t wear his glasses. Back to top Visual Impairments in Children Vision is one of our ...

  1. Data Integrity-A Study of Current Regulatory Thinking and Action.

    Science.gov (United States)

    Shafiei, Nader; De Montardy, Regis; Rivera-Martinez, Edwin

    2015-01-01

    In reaction to breaches of data integrity in the pharmaceutical industry, regulatory authorities have introduced inspection approaches or initiatives with the aim of reducing occurrences of data integrity problems. This review article-based on study of 65 cases of regulatory action from 2002 to 2014-provides an overview of current regulatory thinking and action on breaches of data integrity affecting GxP (health-related regulations) processes supporting non-clinical studies, clinical studies, laboratory controls, and production controls. These case studies largely represent position of the U.S. Food and Drug Administration and the regulatory agencies affiliated with the European Medicines Agency. Also discussed is the role of human factors as a potential source of data integrity problems. The article concludes by recommending some remedial controls that could be established to avoid or reduce occurrences of data integrity problems.Lay Abstract: In fulfilling their mission to protect public health, regulatory agencies (e.g., U.S. Food and Drug Administration, European Medicines Agency) must establish confidence that medical products they approve are fit for their intended use. In so doing they rely on scientific and operational data generated during research, development, manufacturing, sales, marketing, distribution, and post-marketing surveillance activities. The level of confidence they build is directly proportional to the scientific validity and integrity of data presented to them by the sponsors of medical products. In this article we present analysis of 65 case studies that document regulatory action taken by various regulatory agencies on breach of data integrity between 2002 and 2014. The ensuing discussion on current trends largely represents position of the U.S. Food and Drug Administration and European Medicines Agency. The article concludes by proposing some remedial controls that could be established by pharmaceutical companies to avoid or reduce

  2. The study of Zn–Co alloy coatings electrochemically deposited by pulse current

    Directory of Open Access Journals (Sweden)

    Tomić Milorad V.

    2012-01-01

    Full Text Available The electrochemical deposition by pulse current of Zn-Co alloy coatings on steel was examined, with the aim to find out whether pulse plating could produce alloys that could offer a better corrosion protection. The influence of on-time and the average current density on the cathodic current efficiency, coating morphology, surface roughness and corrosion stability in 3% NaCl was examined. At the same Ton/Toff ratio the current efficiency was insignificantly smaller for deposition at higher average current density. It was shown that, depending on the on-time, pulse plating could produce more homogenous alloy coatings with finer morphology, as compared to deposits obtained by direct current. The surface roughness was the greatest for Zn-Co alloy coatings deposited with direct current, as compared with alloy coatings deposited with pulse current, for both examined average current densities. It was also shown that Zn-Co alloy coatings deposited by pulse current could increase the corrosion stability of Zn-Co alloy coatings on steel. Namely, alloy coatings deposited with pulse current showed higher corrosion stability, as compared with alloy coatings deposited with direct current, for almost all examined cathodic times, Ton. Alloy coatings deposited at higher average current density showed greater corrosion stability as compared with coatings deposited by pulse current at smaller average current density. It was shown that deposits obtained with pulse current and cathodic time of 10 ms had the poorest corrosion stability, for both investigated average deposition current density. Among all investigated alloy coatings the highest corrosion stability was obtained for Zn-Co alloy coatings deposited with pulsed current at higher average current density (jav = 4 A dm-2.

  3. Numerical and experimental study of the interaction between two marine current turbines

    CERN Document Server

    Mycek, Paul; Germain, Grégory; Pinon, Grégory; Rivoalen, Elie

    2013-01-01

    The understanding of interaction effects between marine energy converters represents the next step in the research process that should eventually lead to the deployment of such devices. Although some a priori considerations have been suggested recently, very few real condition studies have been carried out concerning this issue. Trials were run on 1/30th scale models of three-bladed marine current turbine prototypes in a flume tank. The present work focuses on the case where a turbine is placed at different locations in the wake of a first one. The interaction effects in terms of performance and wake of the second turbine are examined and compared to the results obtained on the case of one single turbine. Besides, a three-dimensional software, based on a vortex method is currently being developed, and will be used in the near future to model more complex layouts. The experimental study shows that the second turbine is deeply affected by the presence of an upstream device and that a compromise between individu...

  4. Malassezia: Estado del conocimiento y perspectivas en su estudio Malassezia: Current knowledge and study perspectives

    Directory of Open Access Journals (Sweden)

    Gustavo E. Giusiano

    2006-03-01

    knowledge of the ecology and epidemiology of this genus. Noteworthy antifungal susceptibility variations have been observed in some species, although there is not a standard method for these yeasts. There are few data about their biochemical characteristics, and the enzymes they produce might be important virulence factors, favouring host tissue invasion. Malassezia has been recognised as a member of the normal human and animal skin. Its implication in pathologic processes, including skin diseases to systemic infections, is the main issue in current investigations in order to determine the real pathogenic role of these yeasts.

  5. General aspects and current view of the molecular study of Phenylketonuria (PKU in Mexico

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Alcántara-Ortigoza

    2014-07-01

    Full Text Available Phenylketonuria (PKU is an autosomic recessive inborn errors of metabolism. It is caused y the deficiency of phenylalanine hydroxylase, an enzyme encoded by the PAH gene in 12q22. This gene has a wide mutation spectrum and several different genotypes have been identified. There are many experimental strategies that allow molecular diagnosis of PAH in order to identify causal mutations in patients with phenylektonuria. The identification of the PAH genotype in these patients allows genetic counseling, genotype-phenotype correlation and for some cases treatment adjustment. There are few studies concerning the mutation spectrum of PAH in Mexican patients. Currently, a study to identify the genotypes of these patients is being done. Only preliminary results are presented, nevertheless results are expected to clarify the mutation spectrum, enable the identification of possible genotype-phenotype correlations and elucidate the ancestral origin of the mutations.

  6. Association between Cerebral Amyloid Deposition and Clinical Factors Including Cognitive Function in Geriatric Depression: Pilot Study Using Amyloid Positron Emission Tomography

    Science.gov (United States)

    Kim, Hye-Geum; Kong, Eun-Jung; Cheon, Eun-Jin; Kim, Hae-Won; Koo, Bon-Hoon

    2016-01-01

    The purpose of this study was to explore the relationship between cerebral amyloid deposition and overall clinical factors including cognitive functions in geriatric depression by using 18F-florbetaben positron emission tomography. Thirteen subjects aged over 60 years who had a history of major depressive disorder and also had subjective memory complaint were included. Of all subjects, 3 subjects judged as amyloid positive, and the others judged as amyloid negative. Their memory, visuospatial functions and attention abilities were negatively correlated with amyloid deposition in specific brain regions, but their language and recognition abilities were not correlated with any region. The amyloid deposition of the whole brain region was significantly negatively correlated with immediate memory. PMID:27776391

  7. Current management of intracerebral haemorrhage in China: a national, multi-centre, hospital register study

    Directory of Open Access Journals (Sweden)

    Heeley Emma L

    2011-01-01

    Full Text Available Abstract Background We aimed to examine current practice of the management and secondary prevention of intracerebral haemorrhage (ICH in China where the disease is more common than in Western populations. Methods Data on baseline characteristics, management in-hospital and post-stroke, and outcome of ICH patients are from the ChinaQUEST (QUality Evaluation of Stroke Care and Treatment study, a multi-centre, prospective, 62 hospital registry in China during 2006-07. Results Nearly all ICH patients (n = 1572 received an intravenous haemodiluting agent such as mannitol (96% or a neuroprotectant (72%, and there was high use of intravenous traditional Chinese medicine (TCM (42%. Neurosurgery was undertaken in 137 (9% patients; being overweight, having a low Glasgow Coma Scale (GCS score on admission, and Total Anterior Circulation Syndrome (TACS clinical pattern on admission, were the only baseline factors associated with this intervention in multivariate analyses. Neurosurgery was associated with nearly three times higher risk of death/disability at 3 months post-stroke (odd ratio [OR] 2.60, p Conclusions The management of ICH in China is characterised by high rates of use of intravenous haemodiluting agents, neuroprotectants, and TCM, and of antihypertensives for secondary prevention. The controversial efficacy of these therapies, coupled with the current lack of treatments of proven benefit, is a call for action for more outcomes based research in ICH.

  8. Numerical experiments on the detailed energy conversion and spectrum studies in a corona current sheet

    CERN Document Server

    Ni, Lei; Mei, Zhixing; Li, Yan

    2015-01-01

    In this paper, we study the energy conversion and spectra in a corona current sheet by 2.5-dimensional MHD numerical simulations. Numerical results show that many Petschek-like fine structures with slow-mode shocks mediated by plasmoid instabilities develop during the magnetic reconnection process. The termination shocks can also be formed above the primary magnetic island and at the head of secondary islands. These shocks play important roles in generating thermal energy in a corona current sheet. For a numerical simulation with initial conditions close to the solar corona environment, the ratio of the generated thermal energy to the total dissipated magnetic energy is around $1/5$ before secondary islands appear. After secondary islands appear, the generated thermal energy starts to increase sharply and this ratio can reach a value about $3/5$. In an environment with a relatively lower plasma density and plasma $\\beta$, the plasma can be heated to a much higher temperature. After secondary islands appear, t...

  9. Measuring child exposure to violence and mental health reactions in epidemiological studies: challenges and current issues.

    Science.gov (United States)

    Duarte, Cristiane Seixas; Bordin, Isabel Altenfelder Santos; Green, Genevieve Rachel; Hoven, Christina W

    2009-01-01

    This paper examines challenges and current issues involved in measuring exposure to different types of violence which are associated mental health problems in children and adolescents. Standardized measures suitable for epidemiological studies, selected based on their relevance in the current literature, are briefly described and commented. The assessment of child's exposure to violence may focus on a specific event (e.g., kidnapping), a specific context (e.g., war) or even of a certain type of exposure (e.g., intrafamilial physical violence). The assessment of child mental health after exposure to violence has traditionally focused on posttraumatic stress disorder (PTSD) - most frequently measured through non-diagnostic scales. However, other mental health reactions may be present and screening as well as diagnostic instruments which may be used to assess these reactions are also described. Two issues of emerging importance - the assessment of impairment and of traumatic grief in children - are also presented. Availability of culturally appropriate instruments is a crucial step towards proper identification of child mental health problems after exposure to violence.

  10. Eddy currents in the anisotropy of out-of-phase magnetic susceptibility measurement - A model study

    Science.gov (United States)

    Jezek, Josef; Hrouda, Frantisek

    2016-04-01

    Analytical solutions of Maxwell equations for eddy currents caused by AC field in a conductive sphere, known from 1950s, provide a general formula for magnetic susceptibility. It contains the parameters describing the sphere (its size, conductivity and permeability), surrounding medium (permeability) and the applied field (frequency). The formula is complex and without numerical evaluation it is difficult to distinguish the real (in-phase) and imaginary (out-of-phase) part of susceptibility. Representing all the parameters by only two, relative permeability (sphere vs. medium) and skin ratio (summarizing the effect of sphere size, conductivity and permeability, and frequency of the field), we derive approximate formulas for both phases and the phase angle. These are valid for a reasonable range of parameters (from rock magnetism point of view) and enable us to study their influence. The in-phase susceptibility depends very weakly on the fourth power of the skin ratio while the out-of-phase susceptibility depends more strongly on its second power. The coefficients of the dependence are expressed by means of relative permeability. The approximations of in-phase and out-of-phase susceptibilities provide a possibility to assess possible effects of eddy currents in rocks in case of low content of conductive minerals and solve problems of the type by which size one piece of a mineral in the measured sample can produce a phase shift that is observed by measurement. Examples of magnetite and pyrrhotite are given.

  11. Numerical Study of Eddy Shedding By The Loop Current With Ogcm

    Science.gov (United States)

    Tanahara, S.; Crèpon, M.

    The high resolution CLIPPER model for the Atlantic Ocean running at 1/6o was used to study the dynamic of the Gulf of Mexico. The model was daily forced with the ECMWF re-analysis air-sea fluxes during 20 years. A spin-up phase of 10 years is done in the experience. The results show the formation of the Loop Current in the interior of the Gulf of Mexico. This loop detach an anticyclonic eddy northward to Yucatan shelf Peninsula. The size of the eddy is close to 290 Km and 1000 m depth. The eddy shedding periodicity is between 7 to 9 months for the 5 first years of numer- ical forcing simulation. After that, the eddy shedding is blocked and an intensification and deepening of the loop happens. It is found that barotropic transport through Yu- catan channel and vertical structure of cross velocity's Yucatan current are important for eddy shedding process. A hypothesis for the generation and blocking of westward propagation of eddies in the Gulf of Mexico is proposed according to the numerical results.

  12. Tunable Universal Filter with Current Follower and Transconductance Amplifiers and Study of Parasitic Influences

    Science.gov (United States)

    Jeřábek, Jan; Šotner, Roman; Vrba, Kamil

    2011-11-01

    A universal filter with dual-output current follower (DO-CF), two transconductance amplifiers (OTAs) and two passive elements is presented in this paper. The filter is tunable, of the single-input multiple-output (SIMO) type, and operates in the current mode. Our solution utilizes a low-impedance input node and high-impedance outputs. All types of the active elements used can be realized using our UCC-N1B 0520 integrated circuit and therefore the paper contains not only simulation results that were obtained with the help of behavioral model of the UCC-N1B 0520 element, but also the characteristics that were gained by measurement with the mentioned circuit. The presented simulation and measurement results prove the quality of designed filter. Similar multi-loop structures are very-well known, but there are some drawbacks that are not discussed in similar papers. This paper also contains detailed study of parasitic influences on the filter performance.

  13. Dark current and radiation shielding studies for the ILC main linac

    Energy Technology Data Exchange (ETDEWEB)

    Mokhov, Nikolai V. [Fermilab; Rakhno, I. L. [Fermilab; Solyak, N. A. [Fermilab; Sukhanov, A. [Fermilab; Tropin, I. S. [Fermilab

    2016-12-05

    Electrons of dark current (DC), generated in high-gradient superconducting RF cavities (SRF) due to field emission, can be accelerated up to very high energies—19 GeV in the case of the International Linear Collider (ILC) main linac—before they are removed by focusing and steering magnets. Electromagnetic and hadron showers generated by such electrons can represent a significant radiation threat to the linac equipment and personnel. In our study, an operational scenario is analysed which is believed can be considered as the worst case scenario for the main linac regarding the DC contribution to the radiation environment in the main linac tunnel. A detailed modelling is performed for the DC electrons which are emitted from the surface of the SRF cavities and can be repeatedly accelerated in the high-gradient fields in many SRF cavities. Results of MARS15 Monte Carlo calculations, performed for the current main linac tunnel design, reveal that the prompt dose design level of 25 μSv/hr in the service tunnel can be provided by a 2.3-m thick concrete wall between the main and service ls.

  14. A study of diffuser angle effect on ducted water current turbine performance using CFD

    Directory of Open Access Journals (Sweden)

    Adun Janyalertadun

    2012-02-01

    Full Text Available The water current has used as the energy resource for long time however its velocity is very low therefore there arenot found in wide range of uses. This study purposes accelerate water velocity by installing diffuser. The problems wereanalyzed by one dimension analysis and computational fluid dynamics (CFD; the domain covers the diffuser and turbinewhich substituted by porous jump condition is install inside. The flow was identified as axisymmetric steady flow, the inletboundary is identified as uniform flow, all simulation use the same size of diffuser, only the diffuser angles are vary. The resultsshow that velocities of water current in diffuser are increase when the diffuser angle are widen. The angle of diffuser is 20°,the velocity is increase to 1.96 times, compared to free stream velocity. If the angle was about 0-20° and 50-70° the forcetoward diffuser became high instantly; where as the force toward the rotor will be still and the maximum rate of diffuseraugmentation possibly was 3.62 and rotor power coefficient was 2.14.

  15. Transport behavior of hairless mouse skin during constant current DC iontophoresis I: baseline studies.

    Science.gov (United States)

    Liddell, Mark R; Li, S Kevin; Higuchi, William I

    2011-04-01

    The fluxes of charged and nonionic molecules across hairless mouse skin (HMS) were induced by direct current iontophoresis and used to characterize the transport pathways of the epidermal membrane. Experimental data were used to determine permeability coefficients from which the effective pore radii (Rp) of the transport pathways were calculated. Permeants used in these experiments were nonionic permeants (urea, mannitol, and raffinose), monovalent cationic permeants (sodium, tetraethylammonium, and tetraphenylphosphonium ions), and monovalent anionic permeants (chloride, salicylate, and taurocholate ions). The Rp estimates obtained by the anionic permeant pairs were 49, 22, and 20 Å for the chloride/salicylate (Cl:SA), chloride/taurocholate (Cl:TC), and salicylate/taurocholate (SA:TC) pairs, respectively; with the cationic permeant pairs, the Rp values obtained were 19, 30, and 24 Å for the sodium/tetraethylammonium (Na:TEA), sodium/tetraphenylphosphonium (Na:TPP), and the tetraethylammonium/tetraphenylphosphonium (TEA:TPP) pairs, respectively. Rp estimates for HMS obtained from nonionic permeant experiments ranged from 6.7 to 13.4 Å. When plotted versus their respective diffusion coefficients, all of the permeability coefficients for the cationic permeants were greater than those of the anionic permeants. Additionally, the magnitudes of permeability coefficients determined in the current study with HMS were of the same order of magnitude as those previously determined in our laboratory using human epidermal membrane under similar iontophoresis conditions.

  16. Preliminary Study on Element Leaching and Current Soil—Forming Process of Red Soils

    Institute of Scientific and Technical Information of China (English)

    ZHANQI-GUO; XUESHI-KUI; 等

    1991-01-01

    The leaching characteristics and the element concentration in soil solution of red soils derived from sandstone,granite,Quaternary red clay and basalt have been studied in the Red Earth Ecological Experimental Station,Academia Sinica,using 12 lysimeters.Results obtained show that the element leaching process of red soils occurs mainly from January to the beginning of July annually.The elements with higher concentration in leaching solution of red soils are Si,Ca,Na,K,Mg,and N.The desilication and the leaching process of base cations occur simultaneously in the red soils.Using the first order differential equation and measured parameters of Si leaching,the leaching models of Si for red soils derived from different parent materials are constructed.The leaching process of Si is simulated with the models.Both the absolute and relative ages of red soils derived from different parent materials are discussed based on the simulation result.On the basis of element leaching,composition of soil solution and thermodynamics,the current soil-forming process is discussed.According to the phase diagram,the kaolinization is prevailing in the current formation of different red soils.

  17. A study of some political problems considering current geographical analytical parameters

    Directory of Open Access Journals (Sweden)

    Héctor Adolfo Dupuy

    2008-01-01

    Full Text Available This paper intends to study some of the main problems presented, on different scales, by current politics, considering the spatial implications as well as various parameters offered lately by the geographical science. The proposal is supported by the theoretical bases developed from Emmanuel Wallerstein and Peter Taylor's statement about a world system structured as a world economy, based on the capitalist mode of production. Conversely, it attempts to provide a theoretical explanation for the dynamics experienced by the territories upon thee basis of such world system's mechanics. According to these assumptions, an analysis is proposed of some of the main phenomena resulting from the previous analysis and its spatial implications, such as the current power relations in the system, the subsistence of traditional power factors (Nation-states, ethnically based cultural configurations and the appearance of new ones (the forming of transnational blocs and associations, new social movements, new forms of local participation, the importance of hegemonic and counter-hegemonic discourses in the construction of symbolic representations and of the mass media in such processes or the new cultural identity and hybridization chart from population mobility.

  18. An Experimental Study on the Darrieus-Savonius Turbine for the Tidal Current Power Generation

    Science.gov (United States)

    Kyozuka, Yusaku

    The Darrieus turbine is popular for tidal current power generation in Japan. It is simple in structure with straight wings rotating around a vertical axis, so that it has no directionality against the motion of tidal flow which changes its direction twice a day. However, there is one defect in the Darrieus turbine; its small starting torque. Once it stops, a Darrieus turbine is hard to re-start until a fairly fast current is exerted on it. To improve the starting torque of the Darrieus turbine used for tidal power generation, a hybrid turbine, composed of a Darrieus turbine and a Savonius rotor is proposed. Hydrodynamic characteristics of a semi-circular section used for the Savonius bucket were measured in a wind tunnel. The torque of a two bucket Savonius rotor was measured in a circulating water channel, where four different configurations of the bucket were compared. A combined Darrieus and Savonius turbine was tested in the circulating water channel, where the effect of the attaching angle between Darrieus wing and Savonius rotor was studied. Finally, power generation experiments using a 48 pole electric generator were conducted in a towing tank and the power coefficients were compared with the results of experiments obtained in the circulating water channel.

  19. Age at menarche and current substance use among Canadian adolescent girls: results of a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Al-Sahab Ban

    2012-03-01

    Full Text Available Abstract Background Substance use is among the key public health threats that find its genesis during adolescence. Timing of puberty has been lately researched as a potential predictor of subsequent substance abuse. The present study, therefore, aims to assess the effect of age at menarche on current practices of smoking, alcohol drinking and drug use among 14-15 year old Canadian girls. Methods The analysis of the study was based on all female respondents aged 14 to 15 years during Cycle 4 (2000/2001 of the National Longitudinal Survey of Children & Youth (NLSCY. The main independent variable was age at menarche assessed as the month and year of the occurrence of the first menstrual cycle. The dependent variables were current smoking, heavy alcohol drinking in the past 12 months and drug use in the past 12 months. Three logistic regression models were performed to investigate the association between age at menarche and each of the substance use outcomes, adjusting for possible confounders. Bootstrapping was performed to account for the complex sampling design. Results The total weighted sample included in the analysis represented 295,042 Canadian girls. The prevalence of current smokers, heavy drinkers (drunk in the past 12 months and drug users in the past 12 months was approximately 22%, 38% and 26%, respectively. After adjusting of all potential confounders, no association was found between age at menarche and any of the substance use outcomes. School performance and relationship with the father, however, stood out as the main variables to be associated with smoking, heavy drinking and drug use. Conclusions Qualitative studies understanding the social and psychological changes experienced by early maturing Canadian adolescents are warranted to identify other correlates or pathways to substance use in this higher risk population.

  20. A Study of Current Chopping Characteristics in Metal-Carbide Composite Contact Materials

    Science.gov (United States)

    Yamamoto, Atsushi; Kusano, Takashi; Okutomi, Tsutomu; Yokokura, Kunio; Homma, Mitsutaka

    To clarify the effect of carbides on current chopping characteristics chopping current was evaluated for various metalcarbide contact materials. As a result, it was found that the chopping current of metal-carbide contacts was related to the vapor pressure of metals and the work function of carbides. It was also found that the chopping current was reduced by the heat treatment when the melting point of contacts is lower than the temperature of heat teatment.

  1. Prevalence study and risk factor analysis of selected bacterial, protozoal and viral, including vector-borne, pathogens in cats from Cyprus.

    Science.gov (United States)

    Attipa, Charalampos; Papasouliotis, Kostas; Solano-Gallego, Laia; Baneth, Gad; Nachum-Biala, Yaarit; Sarvani, Elpida; Knowles, Toby G; Mengi, Sena; Morris, David; Helps, Chris; Tasker, Séverine

    2017-03-13

    Feline infectious agent studies are lacking in Cyprus. The aims of this study were to determine the prevalence and risk factors for various feline infectious agents, including feline vector-borne pathogens (FVBP), in cats from Cyprus. A cross-sectional, descriptive, multicentre study was performed on 174 feline samples [138 owned and 36 shelter-feral, including both healthy (43) and non-healthy (131), cats] from private veterinary clinics from all six districts of Cyprus. Real-time quantitative polymerase chain reaction (qPCR) assays were used to detect Mycoplasma haemofelis (Mhf), "Candidatus Mycoplasma haemominutum" (CMhm) and "Candidatus Mycoplasma turicensis" (CMt). The population was tested for four FVBP including Bartonella henselae and Leishmania spp. using qPCR, while conventional PCR assays were used to detect Ehrlichia/Anaplasma spp. and Hepatozoon spp. Serological assays were performed to detect Leishmania infantum antibodies, feline leukaemia virus (FeLV) antigen and feline immunodeficiency virus (FIV) antibodies. Statistical analysis was performed to test associations and possible risk factors between variables and infectious agents. Ninety-six (55.2%) of the 174 cats were PCR-positive for at least one infectious agent. Forty-six cats (26.4%) were haemoplasma positive, including 13 (7.5%) for Mhf, 36 (20.7%) for CMhm and 12 (6.9%) for CMt. Sixty-six cats (37.9%) were positive for Hepatozoon spp., while 19 (10.9%) were positive for B. henselae, four (2.3%) for Leishmania spp. and one (0.6%) for Ehrlichia/Anaplasma spp. Sequencing revealed the presence of Hepatozoon felis, L. infantum and Anaplasma platys. Of the 164 cats that underwent retroviral serology, 10 (6.1%) were FeLV-positive and 31 (18.9%) were FIV-positive, while L. infantum serology was positive in 7 (4.4%) of the 160 cats tested. Multivariable logistic regression revealed significant associations for various infectious agents including L. infantum with each of Hepatozoon spp. and CMt

  2. Ayurvedic versus conventional dietary and lifestyle counseling for mothers with burnout-syndrome: A randomized controlled pilot study including a qualitative evaluation.

    Science.gov (United States)

    Kessler, Christian S; Eisenmann, Clemens; Oberzaucher, Frank; Forster, Martin; Steckhan, Nico; Meier, Larissa; Stapelfeldt, Elmar; Michalsen, Andreas; Jeitler, Michael

    2017-10-01

    Ayurveda claims to be effective in the treatment of psychosomatic disorders by means of lifestyle and nutritional counseling. In a randomized controlled study mothers with burnout were randomized into two groups: Ayurvedic nutritional counseling (according to tradition), and conventional nutritional counseling (following the recommendations of a family doctor). Patients received five counseling sessions over twelve weeks. Outcomes included levels of burnout, quality of life, sleep, stress, depression/anxiety, and spirituality at three and six months. It also included a qualitative evaluation of the communication processes. We randomized thirty four patients; twenty three participants were included in the per protocol analysis. No significant differences were observed between the groups. However, significant and clinically relevant intra-group mean changes for the primary outcome burnout, and secondary outcomes sleep, stress, depression and mental health were only found in the Ayurveda group. The qualitative part of the study identified different conversational styles and counseling techniques between the two study groups. In conventional consultations questions tended to be category bound, while counseling-advice was predominantly admonitory. The Ayurvedic practitioner used open-ended interrogative forms, devices for displaying understanding, and positive re-evaluation more frequently, leading to an overall less asymmetrical interaction. We found positive effects for both groups, which however were more pronounced in the Ayurvedic group. The conversational and counseling techniques in the Ayurvedic group offered more opportunities for problem description by patients as well as patient-centered practice and resource-oriented recommendations by the physician. NCT01797887. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

    Directory of Open Access Journals (Sweden)

    Iris M Heid

    2009-10-01

    Full Text Available The INSIG2 rs7566605 polymorphism was identified for obesity (BMI> or =30 kg/m(2 in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34 studies (n = 74,345, including general population (GP studies, population-based studies with subjects selected for conditions related to a better health status ('healthy population', HP, and obesity studies (OB. We tested five hypotheses to explore potential sources of heterogeneity. The meta-analysis of 27 studies on Caucasian adults (n = 66,213 combining the different study designs did not support overall association of the CC-genotype with obesity, yielding an odds ratio (OR of 1.05 (p-value = 0.27. The I(2 measure of 41% (p-value = 0.015 indicated between-study heterogeneity. Restricting to GP studies resulted in a declined I(2 measure of 11% (p-value = 0.33 and an OR of 1.10 (p-value = 0.015. Regarding the five hypotheses, our data showed (a some difference between GP and HP studies (p-value = 0.012 and (b an association in extreme comparisons (BMI> or =32.5, 35.0, 37.5, 40.0 kg/m(2 versus BMI<25 kg/m(2 yielding ORs of 1.16, 1.18, 1.22, or 1.27 (p-values 0.001 to 0.003, which was also underscored by significantly increased CC-genotype frequencies across BMI categories (10.4% to 12.5%, p-value for trend = 0.0002. We did not find evidence for differential ORs (c among studies with higher than average obesity prevalence compared to lower, (d among studies with BMI assessment after the year 2000 compared to those before, or (e among studies from older populations compared to younger. Analysis of non-Caucasian adults (n = 4889 or children (n = 3243 yielded ORs of 1.01 (p-value = 0.94 or 1.15 (p-value = 0.22, respectively. There was no evidence for overall association of the rs7566605 polymorphism with obesity. Our data suggested an association with extreme degrees of obesity, and consequently heterogeneous effects from different study designs may

  4. Effectiveness of interventions on physical activity in overweight or obese children: a systematic review and meta-analysis including studies with objectively measured outcomes.

    Science.gov (United States)

    Nooijen, C F J; Galanti, M R; Engström, K; Möller, J; Forsell, Y

    2017-02-01

    There is no consensus on interventions to be recommended in order to promote physical activity among overweight or obese children. The objective of this review was to assess the effects on objectively measured physical activity, of interventions promoting physical activity among overweight or obese children or adolescents, compared to no intervention or to interventions without a physical activity component. Publications up to December 2015 were located through electronic searches for randomized controlled trials resulting in inclusion of 33 studies. Standardized mean differences from baseline to post-intervention and to long-term follow-up were determined for intervention and control groups and meta-analysed using random effects models. The meta-analysis showed that interventions had no effect on total physical activity of overweight and obese children, neither directly post-intervention (-0.02 [-0.15, 0.11]) nor at long-term follow-up (0.07 [-0.27, 0.40]). Separate analyses by typology of intervention (with or without physical fitness, behavioural or environmental components) showed similar results (no effect). In conclusion, there is no evidence that currently available interventions are able to increase physical activity among overweight or obese children. This questions the contribution of physical activity to the treatment of overweight and obesity in children in the studied interventions and calls for other treatment strategies. © 2017 World Obesity Federation.

  5. Cultured cells of the nervous system, including human neurones, in the study of the neuro-degenerative disorder, Alzheimer's disease: an overview.

    Science.gov (United States)

    De Boni, U

    1985-01-01

    Human nervous-system cells in culture are a suitable model for the study of the degenerative changes associated with Alzheimer's disease. Alzheimer-diseased brain contains a factor which induces the formation of paired helical filaments (PHF) in cultured cells, similar to that seen in Alzheimer's disease. The excitotoxic amino acids, glutamate and aspartate, induce similar PHE formation in cultured cells. The neurotoxic element aluminium is present in high concentrations in the brain in several human neurological disorders, including Alzheimer's disease. In cultured-cell systems, aluminium interacts with acidic nuclear proteins, decreases steroid binding, produces a form of neurofibrillary degeneration and alters nucleoside metabolism.

  6. Utilization study of antidiabetic agents in a teaching hospital of Sikkim and adherence to current standard treatment guidelines

    Directory of Open Access Journals (Sweden)

    Sushrut Varun Satpathy

    2016-01-01

    Full Text Available Objective: Diabetes has gradually emerged as one of the most serious public health problems in our country. This underlines the need for timely disease detection and decisive therapeutic intervention. This prospective cross-sectional observational study aims at analyzing the utilization pattern of antidiabetic agents in a remote North-East Indian tertiary care teaching hospital in the perspective of current standard treatment guidelines. Materials and Methods: Diabetic patients receiving antidiabetic medication, both as outpatients and inpatients in our hospital over a period of 12 months (May 2013–May 2014, were included in this study. The data obtained were sorted and analyzed on the basis of gender, type of therapy, and hospital setting. Results: A total of 310 patients were included in the study. Metformin was the single most frequently prescribed antidiabetic agent (66.8% followed by the sulfonylureas group (37.4%. Insulin was prescribed in 23.2% of the patients. Combination antidiabetic drug therapy (65.1% was used more frequently than monotherapy (34.8%. The use of biguanides (P < 0.0001 and sulfonylureas (P = 0.02 in combination was significant as compared to their use as monotherapy. A total of 48% of all antidiabetic combinations used, comprised metformin and sulfonylureas (n = 96. Insulin use was significantly higher as monotherapy and in inpatients (P< 0.0001. The utilization of drugs from the National List of Essential Medicines was 51.2%, while 11% of antidiabetics were prescribed by generic name. Conclusion: The pattern of utilization largely conforms to the current standard treatment guidelines. Increased use of generic drugs is an area with scope for improvement.

  7. Thymus is enlarged in children with current atopic dermatitis. A cross-sectional study

    DEFF Research Database (Denmark)

    Olesen, Anne Braae; Andersen, G.; Jeppesen, D.L.;

    2005-01-01

    Atopic dermatitis is a common skin disorder of unknown aetiology with peak incidence in early childhood. The disease is associated with peripheral T-cell accumulation in the skin. The thymus is a key organ of the cellular immune response early in life. We hypothesized that atopic dermatitis...... is associated with an unbalanced establishment of the peripheral T-lymphocyte system. This cross-sectional study was performed to compare thymus sizes in patients with atopic dermatitis and healthy controls. Thirty-seven children with current atopic dermatitis were enrolled and compared with 29 healthy controls....... An interview and medical examination were performed by one doctor, an ultrasound scan was performed within 3 days of the examination, and the thymus index, a marker of thymus size, was measured. The thymus index was on average 32% higher (95% CI 3%-67%) in children with active atopic dermatitis compared...

  8. Study of Flavour Changing Neutral Currents in Top Quark Decays with the CMS Detector

    CERN Document Server

    Karafasoulis, C; Vermisoglou, Grigorios; Benucci, Leonardo; Giammanco, Andrea; Palla, Fabrizio

    2006-01-01

    This paper contains the first realistic estimate for the CMS sensitivity to Flavour Changing Neutral Currents (FCNC) in the top quark sector. The non Standard Model decays t -> Zq and t -> gamma q (q represents c or u quarks) have been studied at sqrts = 14 TeV exploiting leptonic decays of the Z boson and the photon. A realistic detector simulation has been adopted and the most relevant systematic effects have been addressed. The 5- sigma discovery limits for the two decays are BR(t-> qZ) =11.4 x 10^ -4 and BR(t -> gamma q ) =5.7 x 10^ -4, allowing some models of new physics to be tested.

  9. Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K+ Current: A Simulation Study

    Science.gov (United States)

    Zhang, Yue; Li, Qince; Zhang, Henggui

    2016-01-01

    Cardiac conduction disorders are common diseases which cause slow heart rate and syncope. The best way to treat these diseases by now is to implant electronic pacemakers, which, yet, have many disadvantages, such as the limited battery life and infection. Biopacemaker has been expected to replace the electronic devices. Automatic ventricular myocytes (VMs) could show pacemaker activity, which was induced by depressing inward-rectifier K+ current (IK1). In this study, a 2D model of human biopacemaker was created from the ventricular endocardial myocytes. We examined the stability of the created biopacemaker and investigated its driving capability by finding the suitable size and spatial distribution of the pacemaker for robust pacing and driving the surrounding quiescent cardiomyocytes. Our results suggest that the rhythm of the pacemaker is similar to that of the single cell at final stable state. The driving force of the biopacemaker is closely related to the pattern of spatial distribution of the pacemaker. PMID:26998484

  10. Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K+ Current: A Simulation Study

    Directory of Open Access Journals (Sweden)

    Yue Zhang

    2016-01-01

    Full Text Available Cardiac conduction disorders are common diseases which cause slow heart rate and syncope. The best way to treat these diseases by now is to implant electronic pacemakers, which, yet, have many disadvantages, such as the limited battery life and infection. Biopacemaker has been expected to replace the electronic devices. Automatic ventricular myocytes (VMs could show pacemaker activity, which was induced by depressing inward-rectifier K+ current (IK1. In this study, a 2D model of human biopacemaker was created from the ventricular endocardial myocytes. We examined the stability of the created biopacemaker and investigated its driving capability by finding the suitable size and spatial distribution of the pacemaker for robust pacing and driving the surrounding quiescent cardiomyocytes. Our results suggest that the rhythm of the pacemaker is similar to that of the single cell at final stable state. The driving force of the biopacemaker is closely related to the pattern of spatial distribution of the pacemaker.

  11. The contribution of Nikola Tesla to plasma physics and current status of plasmas that he studied

    Directory of Open Access Journals (Sweden)

    Petrović Zoran Lj.

    2006-01-01

    Full Text Available One of the main Interests in science of Nikola Tesla were gas discharges plasmas, their application in lighting and in production of ozone as well as their role in conduction of electricity through the atmosphere. In particular Tesla is well known as the first person to produce rf plasmas. Such plasmas in the present day constitute the main technology required to produce integrated circuits (IC and have been essential in the revolution that resulted from IC technologies. In addition Tesla participated in studies of arcs especially arcs used as a source of light, corona discharges required to induce plasma chemical reactions and produce ozone and was involved in various aspects of gas breakdown and gaseous dielectrics. His ideas, level of his understanding and current status of these fields are discussed in this review.

  12. A Study on New Current Controller for 7-Phase BLDC Motor Drive System

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Surk; Jeon, Ywun Seok; Mok, Hyung Soo [Konkuk University (Korea); Kim, Duk Keun [Komotek Co., Ltd. (Korea)

    2001-04-01

    Recently, the demand of motor for industrial, household machinery is increasing. As Switching devices and control technology are progressing, so the use of BLDC Motor is increasing. But 3-phase BLCD Motor generally used has pulsating torque and speed variation in commutation, so the range of its application is limited to high speed operation. Especially, to solve these problems, it is necessary to increase phase of Motor, so study of Poly-Phase BLDC Motor is progressing. However, when hysteresis current controller is used, switching frequency is highly increasing. In this paper, 7-Phase BLDC Motor drive system is designed. Also MSTC (Minimum Switching Time Controller) is proposed and with simulation and experiment, their validities are verified. (author). 10 refs., 26 figs., 1 tab.

  13. Cathodal Transcranial Direct Current Stimulation Improves Focal Hand Dystonia in Musicians: A Two-Case Study

    Directory of Open Access Journals (Sweden)

    Sara Marceglia

    2017-09-01

    Full Text Available Focal hand dystonia (FHD in musicians is a movement disorder causing abnormal movements and irregularities in playing. Since weak electrical currents applied to the brain induce persistent excitability changes in humans, cathodal tDCS was proposed as a possible non-invasive approach for modulating cortical excitability in patients with FHD. However, the optimal targets and modalities have still to be determined. In this pilot study, we delivered cathodal (2 mA, anodal (2 mA and sham tDCS over the motor areas bilaterally for 20 min daily for five consecutive days in two musicians with FHD. After cathodal tDCS, both patients reported a sensation of general wellness and improved symptoms of FHD. In conclusion, our pilot results suggest that cathodal tDCS delivered bilaterally over motor-premotor (M-PM cortex for 5 consecutive days may be effective in improving symptoms in FHD.

  14. Analytic device including nanostructures

    KAUST Repository

    Di Fabrizio, Enzo M.

    2015-07-02

    A device for detecting an analyte in a sample comprising: an array including a plurality of pixels, each pixel including a nanochain comprising: a first nanostructure, a second nanostructure, and a third nanostructure, wherein size of the first nanostructure is larger than that of the second nanostructure, and size of the second nanostructure is larger than that of the third nanostructure, and wherein the first nanostructure, the second nanostructure, and the third nanostructure are positioned on a substrate such that when the nanochain is excited by an energy, an optical field between the second nanostructure and the third nanostructure is stronger than an optical field between the first nanostructure and the second nanostructure, wherein the array is configured to receive a sample; and a detector arranged to collect spectral data from a plurality of pixels of the array.

  15. Curriculum Planning: Trends in Communication Studies, Workplace Competencies, and Current Programs at 4-Year Colleges and Universities

    Science.gov (United States)

    Bertelsen, Dale A.; Goodboy, Alan K.

    2009-01-01

    Many communication scholars recognize the need to regularly explore current communication curriculum and to evaluate its contribution to meeting the needs of students and the demands of the workplace. However, within the communication discipline, current curricular decisions are based on studies conducted nearly a decade ago. This study (a)…

  16. Curriculum Planning: Trends in Communication Studies, Workplace Competencies, and Current Programs at 4-Year Colleges and Universities

    Science.gov (United States)

    Bertelsen, Dale A.; Goodboy, Alan K.

    2009-01-01

    Many communication scholars recognize the need to regularly explore current communication curriculum and to evaluate its contribution to meeting the needs of students and the demands of the workplace. However, within the communication discipline, current curricular decisions are based on studies conducted nearly a decade ago. This study (a)…

  17. Using patient reported outcome measures in health services: A qualitative study on including people with low literacy skills and learning disabilities

    Directory of Open Access Journals (Sweden)

    Jahagirdar Deepa

    2012-11-01

    Full Text Available Abstract Background Patient reported outcome measures (PROMs are self-report measures of health status increasingly promoted for use in healthcare quality improvement. However people with low literacy skills or learning disabilities may find PROMs hard to complete. Our study investigated stakeholder views on the accessibility and use of PROMs to develop suggestions for more inclusive practice. Methods Taking PROMs recommended for chronic obstructive pulmonary disease (COPD as an example, we conducted 8 interviews with people with low literacy skills and/or learning disabilities, and 4 focus groups with 20 health professionals and people with COPD. Discussions covered the format and delivery of PROMs using the EQ-5D and St George Respiratory Questionnaire as prompts. Thematic framework analysis focused on three main themes: Accessibility, Ease of Use, and Contextual factors. Results Accessibility included issues concerning the questionnaire format, and suggestions for improvement included larger font sizes and more white space. Ease of Use included discussion about PROMs’ administration. While health professionals suggested PROMs could be completed in waiting rooms, patients preferred settings with more privacy and where they could access help from people they know. Contextual Factors included other challenges and wider issues associated with completing PROMs. While health professionals highlighted difficulties created by the system in managing patients with low literacy/learning disabilities, patient participants stressed that understanding the purpose of PROMs was important to reduce intimidation. Conclusions Adjusting PROMs’ format, giving an explicit choice of where patients can complete them, and clearly conveying PROMs’ purpose and benefit to patients may help to prevent inequality when using PROMs in health services.

  18. Living conditions, including life style, in primary-care patients with nonacute, nonspecific spinal pain compared with a population-based sample: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Odd Lindell

    2010-11-01

    Full Text Available Odd Lindell, Sven-Erik Johansson, Lars-Erik Strender1Center for Family and Community Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, SwedenBackground: Nonspecific spinal pain (NSP, comprising back and/or neck pain, is one of the leading disorders behind long-term sick-listing, including disability pensions. Early interventions to prevent long-term sick-listing require the identification of patients at risk. The aim of this study was to compare living conditions associated with long-term sick-listing for NSP in patients with nonacute NSP, with a nonpatient population-based sample. Nonacute NSP is pain that leads to full-time sick-listing>3 weeks.Methods: One hundred and twenty-five patients with nonacute NSP, 2000–2004, were included in a randomized controlled trial in Stockholm County with the objective of comparing cognitive–behavioral rehabilitation with traditional primary care. For these patients, a cross-sectional study was carried out with baseline data. Living conditions were compared between the patients and 338 nonpatients by logistic regression. The conditions from univariate analyses were included in a multivariate analysis. The nonsignificant variables were excluded sequentially to yield a model comprising only the significant factors (P <0.05. The results are shown as odds ratios (OR with 95% confidence intervals.Results: In the univariate analyses, 13 of the 18 living conditions had higher odds for the patients with a dominance of physical work strains and Indication of alcohol over-consumption, odds ratio (OR 14.8 (95% confidence interval [CI] 3.2–67.6. Five conditions qualified for the multivariate model: High physical workload, OR 13.7 (CI 5.9–32.2; Hectic work tempo, OR 8.4 (CI 2.5–28.3; Blue-collar job, OR 4.5 (CI 1.8–11.4; Obesity, OR 3.5 (CI 1.2–10.2; and Low education, OR 2.7 (CI 1.1–6.8.Conclusions: As most of the living conditions have previously been

  19. Scheduled Follow-Up Referrals and Simple Prevention Kits Including Counseling to Improve Post-Discharge Outcomes Among Children in Uganda: A Proof-of-Concept Study

    Science.gov (United States)

    Wiens, Matthew O; Kumbakumba, Elias; Larson, Charles P; Moschovis, Peter P; Barigye, Celestine; Kabakyenga, Jerome; Ndamira, Andrew; English, Lacey; Kissoon, Niranjan; Zhou, Guohai; Ansermino, J Mark

    2016-01-01

    ABSTRACT Background: Recurrent illness following hospital discharge is a major contributor to childhood mortality in resource-poor countries. Yet post-discharge care is largely ignored by health care workers and policy makers due to a lack of resources to identify children with recurrent illness and a lack of cohesive systems to provide care. The purpose of this proof-of-concept study was to evaluate the effectiveness of a bundle of interventions at discharge to improve health outcomes during the