WorldWideScience

Sample records for current research involving

  1. Current practice of public involvement activities in biomedical research and innovation: a systematic qualitative review.

    Directory of Open Access Journals (Sweden)

    Jonas Lander

    Full Text Available BACKGROUND: A recent report from the British Nuffield Council on Bioethics associated 'emerging biotechnologies' with a threefold challenge: 1 uncertainty about outcomes, 2 diverse public views on the values and implications attached to biotechnologies and 3 the possibility of creating radical changes regarding societal relations and practices. To address these challenges, leading international institutions stress the need for public involvement activities (PIAs. The objective of this study was to assess the state of PIA reports in the field of biomedical research. METHODS: PIA reports were identified via a systematic literature search. Thematic text analysis was employed for data extraction. RESULTS: After filtering, 35 public consultation and 11 public participation studies were included in this review. Analysis and synthesis of all 46 PIA studies resulted in 6 distinguishable PIA objectives and 37 corresponding PIA methods. Reports of outcome translation and PIA evaluation were found in 9 and 10 studies respectively (20% and 22%. The paper presents qualitative details. DISCUSSION: The state of PIAs on biomedical research and innovation is characterized by a broad range of methods and awkward variation in the wording of objectives. Better comparability of PIAs might improve the translation of PIA findings into further policy development. PIA-specific reporting guidelines would help in this regard. The modest level of translation efforts is another pointer to the "deliberation to policy gap". The results of this review could inform the design of new PIAs and future efforts to improve PIA comparability and outcome translation.

  2. Current practice of public involvement activities in biomedical research and innovation: a systematic qualitative review.

    Science.gov (United States)

    Lander, Jonas; Hainz, Tobias; Hirschberg, Irene; Strech, Daniel

    2014-01-01

    A recent report from the British Nuffield Council on Bioethics associated 'emerging biotechnologies' with a threefold challenge: 1) uncertainty about outcomes, 2) diverse public views on the values and implications attached to biotechnologies and 3) the possibility of creating radical changes regarding societal relations and practices. To address these challenges, leading international institutions stress the need for public involvement activities (PIAs). The objective of this study was to assess the state of PIA reports in the field of biomedical research. PIA reports were identified via a systematic literature search. Thematic text analysis was employed for data extraction. After filtering, 35 public consultation and 11 public participation studies were included in this review. Analysis and synthesis of all 46 PIA studies resulted in 6 distinguishable PIA objectives and 37 corresponding PIA methods. Reports of outcome translation and PIA evaluation were found in 9 and 10 studies respectively (20% and 22%). The paper presents qualitative details. The state of PIAs on biomedical research and innovation is characterized by a broad range of methods and awkward variation in the wording of objectives. Better comparability of PIAs might improve the translation of PIA findings into further policy development. PIA-specific reporting guidelines would help in this regard. The modest level of translation efforts is another pointer to the "deliberation to policy gap". The results of this review could inform the design of new PIAs and future efforts to improve PIA comparability and outcome translation.

  3. Getting involved in research.

    Science.gov (United States)

    Banner, Davina; Grant, Lyle G

    2011-01-01

    The need for quality nursing research to promote evidence-based practice and optimize patient care is well recognized. This is particularly pertinent in cardiovascular nursing, where cardiovascular disease continues to be the leading cause of morbidity and mortality worldwide (World Health Organization, 2007). Across the spectrum of academic, clinical, and health care administration nursing roles, research remains fundamental to bridging theory, practice, and education (LoBiondo-Wood, Haber, Cameron, & Singh, 2009). Despite recognition of the importance of nursing research, the gap between research and practice continues to be an ongoing issue (Funk, Tornquist, & Champagne, 1995; Pettengill, Gillies, & Clark, 1994; Rizzuto, Bostrom, Suterm, & Chenitz, 1994; Rolfe, 1998). Nurses are appropriately situated to contribute to research that improves clinical outcomes and health service delivery. However, the majority of nurses in clinical practice do not have a significant research component structured into their nursing role. In this research column, the authors outline the importance of nurses being engaged in research and present some different levels of involvement that nurses may assume. A continuum of nursing research involvement includes asking researchable questions, being a savvy consumer of research evidence, finding your own level of research involvement, and aspiring to lead.

  4. Current Solid Mechanics Research

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2016-01-01

    About thirty years ago James Lighthill wrote an essay on “What is Mechanics?” With that he also included some examples of the applications of mechanics. While his emphasis was on fluid mechanics, his own research area, he also included examples from research activities in solid mechanics....

  5. Current Research Activities.

    Science.gov (United States)

    1975-02-01

    Biological oceanography, marine food chain dynamics, carbon cycling in the ocean. Martin, Seelye,Ph.D., Johns Hopkins. Geophysical fluid dynamics...currently under investigation, (Ahmed, Packard) 8. Amylase studies An assay for amylase activity has been adapted to measure zooplankton grazing. This...as a function of available food and of the biomass of copepods, was prescribed by sixteen equations: five, corresponding to copepodite stages (I to V

  6. Involving Nepali academics in health research

    DEFF Research Database (Denmark)

    Neupane, Dinesh; van Teijlingen, E; Khanal, V;

    2013-01-01

    Many academics from Nepal do not involve in research activities. There are several factors hindering the involvement such as inadequate human resources and lack of financial resources. Despite limited human and financial resources, we believe it is still possible to attract many Nepali academics...... in health research. This paper purposes some ideas to increase involvement of Nepali academics in health research....

  7. Current issues with research support

    Energy Technology Data Exchange (ETDEWEB)

    Russell, W.T.

    1996-03-01

    It would be difficult to condense current issues in nuclear reactor regulation to just a few minutes. So, let me start off by saying that I have not tried to give a comprehensive listing of issues that are currently facing the reactor program, but rather to select those that I thought were relevant as they relate to research activities. Use of probabilistic risk assessment in regulatory decisions; materials aging issues concerning steam generators and reactor vessels; high burnup fuels; accident management; and digital instrumentation and control, are just a sampling of the important issues that I want to talk about.

  8. Social networks user: current research

    Directory of Open Access Journals (Sweden)

    Agadullina E.R.

    2015-12-01

    Full Text Available The purpose of this article is to review current research studies focusing on the users of Facebook and their behaviors in social networks. This review is organized into two sections: 1 social-demographic characteristics (Age, Gender, Nationality; 2 personality characteristics (Neuroticism, Extraversion, Openness-to-Experience, Agreeableness, Conscientiousness, Narcissism, Self-esteem. The results showed that the information in the personal profile and online behavior are strongly connected with socio-demographic and personality characteristics

  9. Patient involvement in research priorities (PIRE)

    DEFF Research Database (Denmark)

    Piil, Karin; Jarden, Mary

    2016-01-01

    Introduction: Patient involvement in healthcare has expanded from the clinical practice setting to include collaboration during the research process. There has been a growing international interest in patient and public involvement in setting research priorities to reduce the risk of discrepancy ...

  10. Topics in current aerosol research

    CERN Document Server

    Hidy, G M

    1971-01-01

    Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

  11. Consumer involvement in research projects: the activities of research funders.

    Science.gov (United States)

    O'Donnell, Máire; Entwistle, Vikki

    2004-08-01

    This paper reports findings from a postal questionnaire survey and in-depth interviews with UK funders of health-related research that explored whether, why and how they promote consumer involvement in research projects. Many UK funders of health-related research are adopting a policy of promoting consumer involvement in research projects. Telephone interviews revealed they have several reasons for doing so, and that they vary in the ways they encourage and support researchers to involve consumers. For some, descriptions of consumer involvement in a research proposal are important for project funding decisions. They recognized a need for flexibility when assessing consumer involvement in different contexts. We suggest that funders should continue to work to clarify what they consider to be the parameters of acceptability in terms of consumer involvement and ensure that 'flexible' criteria are fairly applied. Researchers should be aware of particular funders' views when applying for project funding.

  12. [User involvement in mental health services research].

    Science.gov (United States)

    Krumm, Silvia; Becker, Thomas

    2006-03-01

    User involvement in mental health services research is discussed in Great Britain, and a number of user-led research initiatives can be found. In Germany, less attention is paid to the concept while virtually no initiatives can be found. The concept of user involvement is introduced by reviewing the relevant literature. After discussion of theoretical and methodological implications, practicability of the concept for mental health services research is illustrated by some examples from Great Britain. User involvement in mental health services may promote the provision of user focused services. User involvement aims at the empowerment of mental health service users and can also improve the quality of mental health services research. Frequently, user-led/collaborative studies are focused on mental health service assessment. Some problematic aspects (e. g. representativeness, knowledge/skills of users) are discussed. Although more research is needed to document the additional benefit of user involvement in mental health services research it is conceivable that the concept will gain in importance.

  13. Consumer involvement in health research: a review and research agenda.

    Science.gov (United States)

    Boote, Jonathan; Telford, Rosemary; Cooper, Cindy

    2002-08-01

    The involvement of consumers in health research is now Department of Health policy within the UK. Despite the existence of policy directives, there is a dearth of knowledge on the effects of such involvement. This paper critically reviews the state of our knowledge on this issue, and maps out a research agenda with the aim of stimulating systematic, empirical inquiry into consumer involvement in health research. The paper discusses definitions of 'the consumer'; considers why consumer involvement is believed to be important to health research; traces the development of the policy; analyses the epistemological and methodological implications of the policy; discusses the various levels of consumer involvement in research; and outlines the objections to the policy that have been put forward by clinicians and researchers. Four questions were identified during the review as being in need of theoretical and empirical attention: (1) how can consumer involvement in health research be further conceptualised? (2) how and why does consumer involvement influence health research? (3) how can the influence of consumers in health research be measured and evaluated? and (4) what factors are associated with 'successful' consumer involvement in health research?

  14. Transparency and public involvement in animal research.

    Science.gov (United States)

    Pound, Pandora; Blaug, Ricardo

    2016-05-01

    To be legitimate, research needs to be ethical, methodologically sound, of sufficient value to justify public expenditure and be transparent. Animal research has always been contested on ethical grounds, but there is now mounting evidence of poor scientific method, and growing doubts about its clinical value. So what of transparency? Here we examine the increasing focus on openness within animal research in the UK, analysing recent developments within the Home Office and within the main group representing the interests of the sector, Understanding Animal Research. We argue that, while important steps are being taken toward greater transparency, the legitimacy of animal research continues to be undermined by selective openness. We propose that openness could be increased through public involvement, and that this would bring about much needed improvements in animal research, as it has done in clinical research. 2016 FRAME.

  15. Current Research in Southeast Asia.

    Science.gov (United States)

    Beh, Yolanda

    1988-01-01

    Briefly describes 22 reports on language-related research relevant to Southeast Asia, detailing study aims, methodology, researchers, and sponsors for studies conducted in Brunei Darussalam, Indonesia, Malaysia, Philippines, Singapore, and Thailand. (CB)

  16. Cell Phones: Current Research Results

    Science.gov (United States)

    ... Potential Biological or Adverse Health Effects of Wireless Communication Devices World Health Organization: Electromagnetic Fields and Public Health: Mobile Phones International Agency for Research on Cancer Press ...

  17. Current concepts in cancer research

    Directory of Open Access Journals (Sweden)

    Ivan Kok Seng Yap

    2013-04-01

    Full Text Available Cancer research is an extremely broadtopic covering many scientific disciplines includingbiology (e.g. biochemistry and signal transduction,chemistry (e.g. drug discover and development,physics (e.g. diagnostic devices and even computerscience (e.g. bioinformatics. Some would argue thatcancer research will continue in much the same wayas it is by adding further layers of complexity to thescientific knowledge that is already complex and almostbeyond measure. But we anticipate that cancer researchwill undergo a dramatic paradigm shift due to therecent explosion of new discoveries in cancer biology.This review article focuses on the latest horizons incancer research concerning cancer epigenetics, cancerstem cells, cancer immunology and cancer metabolism.

  18. Current Research in Southeast Asia.

    Science.gov (United States)

    Beh, Yolanda

    1989-01-01

    Summaries of six language-related research projects are presented from Malaysia, Singapore, and Thailand. Topics include English as the instructional medium, teacher's use of language, Tamil language management, standardizing texts, cross-cultural business negotiations, and assessment of English language needs in computer science. (LB)

  19. Current Research Status of Allelopathy

    Directory of Open Access Journals (Sweden)

    AHMAD JUNAEDI

    2006-06-01

    Full Text Available The term of allelopathy refers to chemical interactions (inhibitory or stimulatory between plants, between plants and microorganisms, and between microorganisms. The wealth of information on the processes, procedures, and practices of allelopathy has contributed to understanding this field of science. Recently, researches of allelopathy have been conducted in laboratory, greenhouse, and field with multifaceted standpoint in some concerning area: (i allelochemicals identifications and screening test; (ii ecological and physiological aspects of allelopathy; (iii genetic studies and the possibilities of using plant breeding or genetic manipulation to enhance allelopathic varieties; (iv the use of allelopathic potential in the biological control, including as natural pesticide, of weeds and plant diseases as eco-friendly approach for sustainable agriculture scheme.

  20. Genomic Aspects of Research Involving Polyploid Plants

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xiaohan [ORNL; Ye, Chuyu [ORNL; Tschaplinski, Timothy J [ORNL; Wullschleger, Stan D [ORNL; Tuskan, Gerald A [ORNL

    2011-01-01

    Almost all extant plant species have spontaneously doubled their genomes at least once in their evolutionary histories, resulting in polyploidy which provided a rich genomic resource for evolutionary processes. Moreover, superior polyploid clones have been created during the process of crop domestication. Polyploid plants generated by evolutionary processes and/or crop domestication have been the intentional or serendipitous focus of research dealing with the dynamics and consequences of genome evolution. One of the new trends in genomics research is to create synthetic polyploid plants which provide materials for studying the initial genomic changes/responses immediately after polyploid formation. Polyploid plants are also used in functional genomics research to study gene expression in a complex genomic background. In this review, we summarize the recent progress in genomics research involving ancient, young, and synthetic polyploid plants, with a focus on genome size evolution, genomics diversity, genomic rearrangement, genetic and epigenetic changes in duplicated genes, gene discovery, and comparative genomics. Implications on plant sciences including evolution, functional genomics, and plant breeding are presented. It is anticipated that polyploids will be a regular subject of genomics research in the foreseeable future as the rapid advances in DNA sequencing technology create unprecedented opportunities for discovering and monitoring genomic and transcriptomic changes in polyploid plants. The fast accumulation of knowledge on polyploid formation, maintenance, and divergence at whole-genome and subgenome levels will not only help plant biologists understand how plants have evolved and diversified, but also assist plant breeders in designing new strategies for crop improvement.

  1. Current Research on Antiepileptic Compounds

    Directory of Open Access Journals (Sweden)

    Cheng-Xi Wei

    2015-11-01

    Full Text Available Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy.

  2. Public involvement in breast cancer research: an analysis and model for future research.

    Science.gov (United States)

    McCormick, Sabrina; Brody, Julia; Brown, Phil; Polk, Ruth

    2004-01-01

    Public involvement in health program planning has been taking place for many years, and has provided a precedent for the emergence of public involvement in research conducted since the early 1990s. Such involvement is now widely seen in breast cancer research, due to the large public concern and major social movement activity. This article reviews current practices and general models of public involvement in research and constructs a prototype. The authors interviewed researchers, program officers, and laypeople in order to understand the obstacles, processes, and benefits. They conclude that public involvement has major ramifications for the democratization of science and the construction of knowledge by teaching lay people about science and sensitizing researchers to concerns of the public. There is growing support on the part of scientists and government agents for public involvement.

  3. Principles for ethical research involving humans: ethical professional practice in impact assessment Part I

    National Research Council Canada - National Science Library

    Vanclay, Frank; Baines, James T; Taylor, C. Nicholas

    2013-01-01

    ... methods textbooks, this paper identifies current principles for ethical research involving humans and discusses their implications for impact assessment practice generally and social impact assessment specifically...

  4. Neuropsychiatric involvement in systemic lupus erythematosus: current therapeutic approach.

    Science.gov (United States)

    Sanna, Giovanni; Bertolaccini, Maria Laura; Khamashta, Munther A

    2008-01-01

    The involvement of the central nervous system (CNS) is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients and the less understood aspect of the disease. Its recognition and treatment continue to represent a major diagnostic and therapeutic challenge. Due to the lack of controlled randomized trials, current therapeutic approach is still empirical and based on clinical experience. The therapeutic choice depends on accurate diagnosis, identification of underlying pathogenic mechanism, severity of the presenting neuropsychiatric symptoms, and on prompt identification and management of contributing causes of CNS disease. Mild neuropsychiatric manifestations may need symptomatic treatment only. In more severe CNS disease it is important to distinguish between thrombotic and non-thrombotic mechanisms. Focal CNS manifestations, particularly TIA and stroke, are associated with the presence of antiphospholipid antibodies (aPL). Anticoagulation is warranted in patients with thrombotic disease, particularly in those with the antiphospholipid (Hughes) syndrome (APS). Other CNS manifestations, such as demyelinating syndrome, transverse myelitis, chorea, seizures, migraine and/or cognitive dysfunction, when associated with persistent positivity for aPL, may also benefit from anticoagulation in selected patients. Severe diffuse CNS manifestations, such as acute confusional state, generalised seizures, mood disorders and psychosis, generally require corticosteroids in the first instance. Pulse intravenous cyclophosphamide therapy may help when more severe manifestations are refractory to corticosteroids and other immunosuppressive agents, generally when response is not seen in 3-5 days. Plasmapheresis may also be added in severe cases of symptoms refractory to conventional treatment. Intravenous immunoglobulins, mycophenolate mofetil, rituximab, intratecal methotrexate and dexametasone deserve further studies to confirm their

  5. Resident Involvement in Professional Otolaryngology Organizations: Current Trends in the United States.

    Science.gov (United States)

    Wong, Kevin; Jang, Minyoung; Gilad, Amir; Levi, Jessica R

    2017-08-01

    Involvement by residents in professional medical organizations can enrich their training, but little data exist regarding the number and types of involvement opportunities available to otolaryngology residents. We sought to fill this gap in knowledge by quantifying the extent to which major otolaryngology-related organizations in the United States provide involvement opportunities to otolaryngology residents. Our analysis included 23 organizations and subspecialty societies. Results showed that many opportunities exist for residents to attend conferences and present research; however, fewer involvement and funding opportunities existed in any other leadership, health policy, or service-learning experiences. These findings were consistent across general and subspecialty societies. Given the many purported benefits of resident involvement in otolaryngology outside of the standard training environment, future efforts may be warranted to increase the number and type of involvement opportunities currently available in professional societies.

  6. Current challenges in dedifferentiated fat cells research.

    Science.gov (United States)

    Shah, Mickey; George, Richard L; Evancho-Chapman, M Michelle; Zhang, Ge

    2016-07-02

    Dedifferentiated fat cells show great promises as a novel cell source for stem cell research. It has many advantages when used for cell-based therapeutics including abundance, pluripotency, and safety. However, there are many obstacles researchers need to overcome to make the next big move in DFAT cells research. In this review, we summarize the current main challenges in DFAT cells research including cell culture purity, phenotypic properties, and dedifferentiation mechanisms. The common methods to produce DFAT cells as well as the cell purity issue during DFAT cell production have been introduced. Current approaches to improve DFAT cell purity have been discussed. The phenotypic profile of DFAT cells have been listed and compared with other stem cells. Further studies on elucidating the underlying dedifferentiation mechanisms will dramatically advance DFAT cell research.

  7. 45 CFR 46.205 - Research involving neonates.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Research involving neonates. 46.205 Section 46.205... SUBJECTS Additional Protections for Pregnant Women, Human Fetuses and Neonates Involved in Research § 46.205 Research involving neonates. (a) Neonates of uncertain viability and nonviable neonates may...

  8. Current research on aviation weather (bibliography), 1979

    Science.gov (United States)

    Turkel, B. S.; Frost, W.

    1980-01-01

    The titles, managers, supporting organizations, performing organizations, investigators and objectives of 127 current research projects in advanced meteorological instruments, forecasting, icing, lightning, visibility, low level wind shear, storm hazards/severe storms, and turbulence are tabulated and cross-referenced. A list of pertinent reference material produced through the above tabulated research activities is given. The acquired information is assembled in bibliography form to provide a readily available source of information in the area of aviation meteorology.

  9. The value of consumer involvement in research.

    Science.gov (United States)

    Halcomb, Liz

    2016-11-18

    Ensuring consumers are engaged in health research is not a new idea. As researchers we know that considering the needs and preferences of potential participants is a recruitment and/or retention strategy. Funding bodies and ethics committees often look favourably on projects that can demonstrate consumer input.

  10. Digital library research : current developments and trends

    OpenAIRE

    Shiri, Ali

    2003-01-01

    This column gives an overview of current trends in digital library research under the following headings: digital library architecture, systems, tools and technologies; digital content and collections; metadata; interoperability; standards; knowledge organisation systems; users and usability; legal, organisational, economic, and social issues in digital libraries.

  11. Patient involvement in clinical research: why, when, and how

    Directory of Open Access Journals (Sweden)

    Sacristán JA

    2016-04-01

    Full Text Available José A Sacristán,1 Alfonso Aguarón,2 Cristina Avendaño-Solá,3 Pilar Garrido,4 Juan Carrión,5 Alipio Gutiérrez,6 Robert Kroes,7 Angeles Flores11Medical Department, Lilly Spain, 2Myeloma Patients Europe, 3Research Ethics Committee, University Hospital Puerta de Hierro, 4Oncology Department, Hospital Ramón y Cajal, 5FEDER (Spanish Federation for Rare Diseases, 6National Association of Health Journalists, Madrid, Spain; 7Clinical Open Innovation, Lilly Europe, Amsterdam, the Netherlands Abstract: The development of a patient-centered approach to medicine is gradually allowing more patients to be involved in their own medical decisions. However, this change is not happening at the same rate in clinical research, where research generally continues to be carried out on patients, but not with patients. This work describes the why, when, and how of more active patient participation in the research process. Specific measures are proposed to improve patient involvement in 1 setting priorities, 2 study leadership and design, 3 improved access to clinical trials, 4 preparation and oversight of the information provided to participants, 5 post-study evaluation of the patient experience, and 6 the dissemination and application of results. In order to achieve these aims, the relative emphases on the ethical principles underlying research need to be changed. The current model based on the principle of beneficence must be left behind, and one that upholds the ethical principles of autonomy and non maleficence should be embraced. There is a need to improve the level of information that patients and society as a whole have on research objectives and processes; the goal is to promote the gradual emergence of the expert patient.Keywords: patients, research, clinical trials, bioethics, engagement

  12. Current research of hepatic cirrhosis in China

    Institute of Scientific and Technical Information of China (English)

    Xi-Xian Yao; Shu-Lin Jiang; Dong-Mei Yao

    2005-01-01

    Hepatic cirrhosis is a common disease that poses a serious threat to public health, and is characterized by chronic,progressive and diffuse hepatic lesions preceded by hepaticfibrosis regardless of the exact etiologies. In recent years,considerable achievements have been made in China in research of the etiopathogenesis, diagnosis and especially the treatment of hepatic fibrosis, resulting in much improved prognosis of hepatic fibrosis and cirrhosis. In this paper, the authors review the current status of research in hepatic fibrosis, cirrhosis and their major complications.

  13. Medical Robots: Current Systems and Research Directions

    OpenAIRE

    Beasley, Ryan A.

    2012-01-01

    First used medically in 1985, robots now make an impact in laparoscopy, neurosurgery, orthopedic surgery, emergency response, and various other medical disciplines. This paper provides a review of medical robot history and surveys the capabilities of current medical robot systems, primarily focusing on commercially available systems while covering a few prominent research projects. By examining robotic systems across time and disciplines, trends are discernible that imply future capabilities ...

  14. Integrated fundamental research on current collection

    Science.gov (United States)

    Kuhlmann-Wilsdorf, Doris; Tran, Leo

    1993-06-01

    The aim of our research was to add to the basic understanding in the area of current collection with particular emphasis on topics likely to benefit practical objectives. Under sponsorship of this contract, 23 papers were published in the international literature. Additionally, 13 invited lectures and 11 contributed lectures on various aspects of this research were delivered at universities, research laboratories, and international conferences by the principal investigator and co-workers. The development of a novel metal fiber material for sliding electrical contacts was continued with much success. This is expected to become very useful for making metal fiber brushed for homopolar motors/generators, as well as for EML armatures. Included in this report are title pages (and abstracts) for the 23 published papers.

  15. Consistent gauge interaction involving dynamical coupling and anomalous current

    CERN Document Server

    Guendelman, Eduardo I

    2015-01-01

    We show a possible way to construct a consistent formalism where the effective electric charge can change with space and time without destroying the invariance. In the previous work [1][2] we took the gauge coupling to be of the form $g(\\phi)j_\\mu (A^{\\mu} +\\partial^{\\mu}B)$ where $B$ is an auxiliary field, $ \\phi $ is a scalar field and the current $j_\\mu$ is the Dirac current. This term produces a constraint $ (\\partial_{\\mu}\\phi) j^{\\mu}=0 $ which can be related to M.I.T bag model by boundary condition. In this paper we show that when we use the term $ g(\\phi)j_{\\mu}(A^{\\mu} - \\partial^{\\mu}(\\frac{1}{\\square}\\partial_{\\rho}A^{\\rho})) $, instead of the auxiliary field $ B $, there is a possibility to produce a theory with dynamical coupling constant, which does not produce any constraint or confinement. The coupling $ j_{\\mu}^{A}(A^{\\mu} - \\partial^{\\mu}(\\frac{1}{\\square}\\partial_{\\rho}A^{\\rho})) $ where $ j_{\\mu}^{A} $ is an anomalous current also discussed.

  16. Research Education: Perspectives and subjective processes involved in educational research

    Directory of Open Access Journals (Sweden)

    Harm H. Tillema

    2009-10-01

    Full Text Available Educational research acknowledges that researcher’s beliefs and training play a role in framing the outcomes of any study. Research not only consists of defining objectives and following certain methods (search but also of making decisions over the steps taking during the inquiry process (research.Establishing a conceptual framework to guide actions on the subjective processes in research is then crucial to control them. With that purpose in mind we offer researchers and Teacher Educators a heuristic tool to be conscious on the risks that can be taken when immersed in research interpretative process. This instrument could be utilised in PhD programs, masters and research projects.

  17. Paying research participants: a study of current practices in Australia.

    Science.gov (United States)

    Fry, C L; Ritter, A; Baldwin, S; Bowen, K J; Gardiner, P; Holt, T; Jenkinson, R; Johnston, J

    2005-09-01

    To examine current research payment practices and to inform development of clearer guidelines for researchers and ethics committees. Exploratory email based questionnaire study of current research participant reimbursement practices. A diverse sample of organisations and individuals were targeted. Australia. Contacts in 84 key research organisations and select electronic listservers across Australia. A total of 100 completed questionnaires were received with representations from a variety of research areas (for example, market, alcohol and drug, medical, pharmaceutical and social research). Open-ended and fixed alternative questions about type of research agency; type of research; type of population under study; whether payment is standard; amounts and mechanisms of payment; factors taken into account when deciding on payment practices; and whether payment policies exist. Reimbursement practice is highly variable. Where it occurs (most commonly for drug dependent rather than health professional or general population samples) it is largely monetary and is for time and out-of-pocket expenses. Ethics committees were reported to be often involved in decision making around reimbursement. Research subject payment practices vary in Australia. Researchers who do provide payments to research participants generally do so without written policy and procedures. Ethics committees have an important role in developing guidelines in this area. Specific guidelines are needed considering existing local policies and procedures; payment models and their application in diverse settings; case study examples of types and levels of reimbursement; applied definitions of incentive and inducement; and the rationale for diverse payment practices in different settings.

  18. Accessible Article: Involving People with Learning Disabilities in Research

    Science.gov (United States)

    Garbutt, Ruth; Tattersall, John; Dunn, Jo; Boycott-Garnett, Rachel

    2010-01-01

    This is an article that talks about our research about sex and relationships for people with learning disabilities. It talks about how people with learning disabilities have been fully involved in the research. (Contains 2 footnotes.)

  19. Medical Robots: Current Systems and Research Directions

    Directory of Open Access Journals (Sweden)

    Ryan A. Beasley

    2012-01-01

    Full Text Available First used medically in 1985, robots now make an impact in laparoscopy, neurosurgery, orthopedic surgery, emergency response, and various other medical disciplines. This paper provides a review of medical robot history and surveys the capabilities of current medical robot systems, primarily focusing on commercially available systems while covering a few prominent research projects. By examining robotic systems across time and disciplines, trends are discernible that imply future capabilities of medical robots, for example, increased usage of intraoperative images, improved robot arm design, and haptic feedback to guide the surgeon.

  20. Topics in current aerosol research (part2)

    CERN Document Server

    Hidy, G M

    1972-01-01

    Topics in Current Aerosol Research, Part 2 contains some selected articles in the field of aerosol study. The chosen topics deal extensively with the theory of diffusiophoresis and thermophoresis. Also covered in the book is the mathematical treatment of integrodifferential equations originating from the theory of aerosol coagulation. The book is the third volume of the series entitled International Reviews in Aerosol Physics and Chemistry. The text offers significant understanding of the methods employed to develop a theory for thermophoretic and diffusiophoretic forces acting on spheres in t

  1. Enhancing public involvement in assistive technology design research.

    Science.gov (United States)

    Williamson, Tracey; Kenney, Laurence; Barker, Anthony T; Cooper, Glen; Good, Tim; Healey, Jamie; Heller, Ben; Howard, David; Matthews, Martin; Prenton, Sarah; Ryan, Julia; Smith, Christine

    2015-05-01

    To appraise the application of accepted good practice guidance on public involvement in assistive technology research and to identify its impact on the research team, the public, device and trial design. Critical reflection and within-project evaluation were undertaken in a case study of the development of a functional electrical stimulation device. Individual and group interviews were undertaken with lay members of a 10 strong study user advisory group and also research team members. Public involvement was seen positively by research team members, who reported a positive impact on device and study designs. The public identified positive impact on confidence, skills, self-esteem, enjoyment, contribution to improving the care of others and opportunities for further involvement in research. A negative impact concerned the challenge of engaging the public in dissemination after the study end. The public were able to impact significantly on the design of an assistive technology device which was made more fit for purpose. Research team attitudes to public involvement were more positive after having witnessed its potential first hand. Within-project evaluation underpins this case study which presents a much needed detailed account of public involvement in assistive technology design research to add to the existing weak evidence base. The evidence base for impact of public involvement in rehabilitation technology design is in need of development. Public involvement in co-design of rehabilitation devices can lead to technologies that are fit for purpose. Rehabilitation researchers need to consider the merits of active public involvement in research.

  2. Palliative care and involvement of anaesthesiology: current discussions.

    Science.gov (United States)

    Kettler, Dietrich; Nauck, Friedemann

    2010-04-01

    To summarize various developments related to palliative care, especially related to ethical issues. To emphasize the involvement of anaesthesiology in palliative care. Euthanasia has been legalized in Belgium, the Netherlands and Luxemburg (BENELUX countries). A group from Belgium has now proposed using euthanasia in patients in whom palliative care has been deemed 'futile'. This practice of so-called 'integral palliative care' is strongly rejected in a study from Germany. Palliative sedation is an ethically different approach with no intention to kill the patient. The European Association of Palliative Care has proposed a framework for individual guidelines for palliative sedation. The important role of anaesthesiology in palliative care teams is emphasized. Palliative care is a powerful approach to patient care during terminal illness, emphasizing quality of life even if it may shorten the length of life. Traditionally, palliative care has been contrasted with active euthanasia, but a group from Belgium has challenged this concept recently, advocating the use of euthanasia in circumstances in which palliative care has become 'futile'. This new approach led to strong reactions by a group from Germany, stressing that killing on demand in palliative care should under no circumstances be justified. In contrast, palliative sedation is a common method in special cases to reduce intractable symptoms. A new framework for palliative sedation produced by the European Association of Palliative Care may encourage institutions to set up their own palliative sedation guidelines. Worldwide, anaesthesiologists have a significant role in palliative care due to their unique complex expertise mainly in pain therapy and including transient sedation of patients.

  3. Agriculture for improved nutrition: the current research landscape.

    Science.gov (United States)

    Turner, Rachel; Hawkes, Corinna; Jeff, Waage; Ferguson, Elaine; Haseen, Farhana; Homans, Hilary; Hussein, Julia; Johnston, Deborah; Marais, Debbi; McNeill, Geraldine; Shankar, Bhavani

    2013-12-01

    Concern about food security and its effect on persistent undernutrition has increased interest in how agriculture could be used to improve nutritional outcomes in developing countries. Yet the evidence base for the impact of agricultural interventions targeted at improved nutrition is currently poor. To map the extent and nature of current and planned research on agriculture for improved nutrition in order to identify gaps where more research might be useful. The research, which was conducted from April to August 2012, involved developing a conceptual framework linking agriculture and nutrition, identifying relevant research projects and programs, devising and populating a "template" with details of the research projects in relation to the conceptual framework, classifying the projects, and conducting a gap analysis. The study identified a large number of research projects covering a broad range of themes and topics. There was a strong geographic focus on sub-Saharan Africa, and many studies were explicitly concerned with nutritional impacts on women and children. Although the study revealed a diverse and growing body of research, it also identified research gaps. Few projects consider the entire evidence chain linking agricultural input or practice to nutritional outcomes. There is comparatively little current research on indirect effects of agriculture on nutrition, or the effect of policies or governance, rather than technical interventions. Most research is focused on undernutrition and small farmer households, and few studies target consumers generally, urban populations, or nutrition-related non-communicable diseases. There is very little work on the cost-effectiveness of agricultural interventions. On the basis of these findings, we make suggestions for research investment and for broader engagement of researchers and disciplines in developing approaches to design and evaluate agricultural programs for improved nutrition.

  4. Leadership: current theories, research, and future directions.

    Science.gov (United States)

    Avolio, Bruce J; Walumbwa, Fred O; Weber, Todd J

    2009-01-01

    This review examines recent theoretical and empirical developments in the leadership literature, beginning with topics that are currently receiving attention in terms of research, theory, and practice. We begin by examining authentic leadership and its development, followed by work that takes a cognitive science approach. We then examine new-genre leadership theories, complexity leadership, and leadership that is shared, collective, or distributed. We examine the role of relationships through our review of leader member exchange and the emerging work on followership. Finally, we examine work that has been done on substitutes for leadership, servant leadership, spirituality and leadership, cross-cultural leadership, and e-leadership. This structure has the benefit of creating a future focus as well as providing an interesting way to examine the development of the field. Each section ends with an identification of issues to be addressed in the future, in addition to the overall integration of the literature we provide at the end of the article.

  5. Ethical and Social Issues in Health Research Involving Incarcerated People.

    Science.gov (United States)

    Coughlin, Steven S; Lewis, Sharon R; Smith, Selina A

    2016-01-01

    The use of inmates in research in the U.S. was restricted by the recommendations of the National Commission and by federal regulations and guidelines that followed. By the 1980s, many health care officials became concerned about the exclusion of inmates from experimental treatments for human immunodeficiency virus infection (HIV). These developments in ethics occurred in the context of racial/ethnic disparities in health. In this article, ethical considerations in clinical and public health research on HIV in prison and jail settings are considered. Ethical considerations in mental health research are summarized as well as issues pertaining to research involving female inmates. Issues related to oversight of research involving incarcerated people are considered along with the ethics of public health research. The ethics of research involving incarcerated people extends beyond traditional issues in human subjects ethics to include issues within the domains of bioethics and public health ethics.

  6. Current and Future Research at DANCE

    Directory of Open Access Journals (Sweden)

    Jandel M.

    2015-01-01

    Full Text Available An overview of the current experimental program on measurements of neutron capture and neutron induced fission at the Detector for Advanced Neutron Capture Experiments (DANCE is presented. Three major projects are currently under way: 1 high precision measurements of neutron capture cross sections on Uranium isotopes, 2 research aimed at studies of the short-lived actinide isomer production in neutron capture on 235U and 3 measurements of correlated data of fission observables. New projects include developments of auxiliary detectors to improve the capability of DANCE. We are building a compact, segmented NEUtron detector Array at DANCE (NEUANCE, which will be installed in the central cavity of the DANCE array. It will provide experimental information on prompt fission neutrons in coincidence with the prompt fission gamma-rays measured by 160 BaF2 crystals of DANCE. Unique correlated data will be obtained for neutron capture and neutron-induced fission using the DANCE-NEUANCE experimental set up in the future.

  7. Current and Future Research at DANCE

    Science.gov (United States)

    Jandel, M.; Baramsai, B.; Bredeweg, T. A.; Couture, A.; Hayes, A.; Kawano, T.; Mosby, S.; Rusev, G.; Stetcu, I.; Taddeucci, T. N.; Talou, P.; Ullmann, J. L.; Walker, C. L.; Wilhelmy, J. B.

    2015-05-01

    An overview of the current experimental program on measurements of neutron capture and neutron induced fission at the Detector for Advanced Neutron Capture Experiments (DANCE) is presented. Three major projects are currently under way: 1) high precision measurements of neutron capture cross sections on Uranium isotopes, 2) research aimed at studies of the short-lived actinide isomer production in neutron capture on 235U and 3) measurements of correlated data of fission observables. New projects include developments of auxiliary detectors to improve the capability of DANCE. We are building a compact, segmented NEUtron detector Array at DANCE (NEUANCE), which will be installed in the central cavity of the DANCE array. It will provide experimental information on prompt fission neutrons in coincidence with the prompt fission gamma-rays measured by 160 BaF2 crystals of DANCE. Unique correlated data will be obtained for neutron capture and neutron-induced fission using the DANCE-NEUANCE experimental set up in the future.

  8. Active involvement of people with intellectual disabilities in health research - A structured literature review

    NARCIS (Netherlands)

    Frankena, T.K.; Naaldenberg, J.; Cardol, M.; Linehan, C.; Schrojenstein Lantman-de Valk, H.M. van

    2015-01-01

    Actively involving people with intellectual disabilities (ID) in health research, also known as inclusive health research, is increasingly popular. Currently, insight into experiences of this type of research is scarce. To gain insight into this topic, a structured literature review was conducted

  9. Overcoming the challenges to consumer involvement in cancer research

    OpenAIRE

    Stevens, Tony; Wilde, David; Hunt, John; Ahmedzai, Sam H

    2003-01-01

    Introduction  Within the last decade, there have been many government initiatives to promote consumer involvement in research, especially in cancer. At the same time, the number and influence of consumer groups themselves have expanded. However, the organizational infrastructure necessary to facilitate consumer involvement has not been developed. Consequently, consumer involvement has tended to remain essentially localized and project driven, with no strategic or regional lead.

  10. Removing the College Involvement "Research Asterisk": Identifying and Rethinking Predictors of American Indian College Student Involvement

    Science.gov (United States)

    Garland, John L.

    2010-01-01

    The purpose of this study was to identify campus environmental predictors of American Indian college student involvement. The American Indian research asterisk, or not including American Indian data, has prevailed over student development research for decades. As a result, student affairs professionals have been limited in their ability to develop…

  11. Current research directions definition of economic security

    Directory of Open Access Journals (Sweden)

    Anna Falovych

    2013-05-01

    Full Text Available The article features the topical issue of the established level of the enterprise's economic security. The objective of this article is to research, to base and to supplement the tendency for generalization of the categorical system in order to clarify the matter meaning of the enterprise's economic security. The systematized analyses of the matter meaning of the enterprise's economic security were done by domestic and foreign scientists-economists. The results of the study were expounded and also some vital approaches to the definition of the enterprise's economic security were presented and proved particularly: strategically, resource-functional, marketable, combined, deductive, systematic and criminal.Based on the analyzed content-conceptual interpretations and detailed characteristics of each approach to the definition of this meaning, there was proposed its own meaning of the interpretation of the enterprise's economic security. A systematic approach was adopted due to the matters concerning enterprise's economic security. As in this approach the vital economic interests of thee enterprise were stipulated, also gained the topicality in the current crisis economic conditions

  12. CURRENT ANSTO RESEARCH ON WASTEFORM DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Vance, E.R.; Perera, D.S.; Stewart, M.W.A.; Begg, B.D.; Carter, M.L.; Day, R.A.; Moricca, S.; Smith, K.L.; Lumpkin, G.R.; Hanna, J.V.

    2003-02-27

    Current ANSTO scientific research on wasteform development for mainly high-level radioactive waste is directed towards practical applications. Titanate wasteform products we have developed or are developing are aimed at immobilization of: (a) tank wastes and sludges; (b) U-rich wastes from radioisotope production from reactor irradiation of UO2 targets; (c) Al-rich wastes arising from reprocessing of Al-clad fuels; (d) 99Tc; (e) high- Mo wastes arising from reprocessing of U-Mo fuels and (f) partitioned Cs-rich wastes. Other wasteforms include encapsulated zeolites or silica/alumina beads for immobilization of 129I. Wasteform production techniques cover hot isostatic and uniaxial pressing, sintering, and cold-crucible melting. In addition, building on previous work on speciation and leach resistance of Cs in cementitious products, we are studying geopolymers. Although we have a strong focus on candidate wasteforms for actual wastes, we have a considerable program directed at basic understanding of the wasteforms in regard to crystal chemistry, their dissolution behavior in aqueous media, radiation damage effects and processing techniques.

  13. Status, challenges and facilitators of consumer involvement in Australian health and medical research

    Directory of Open Access Journals (Sweden)

    Girgis Afaf

    2010-11-01

    Full Text Available Abstract Background The emergent international practice of involving consumers in health research is driven, in part, by the growing share of health research that can only be applied in and emerge from knowledge that is shaped by human values and societal contexts. This is the first investigation of its kind to identify the current prevalence, challenges, enabling factors and range of approaches to consumer involvement in health and medical research in Australia. Methods A nation-wide survey of research funding organisations and organisations that conduct research was performed during 2008-2009. Results Marked variation in consumer involvement experience and perceptions exists between research funders and researchers. Research funders were over eight times more likely than organisations conducting research to involve consumers in identifying research needs and prioritising research topics. Across both groups, practical and time constraints were reported as key challenges to involving consumers, while guidelines on consumer involvement and evidence of effect were the most important potential enablers. More than a third of research organisations indicated that when consumer involvement was a condition of research funding, it was an important facilitator of involvement. Conclusion It is no longer simply enough to keep society informed of important scientific breakthroughs. If Australian health research is to take into account important social contexts and consequences, it must involve consumers. A set of minimum consumer involvement standards and associated guidelines, that are agreed and routinely adopted, could ensure that consumers and the Australian community they represent, are given an opportunity to shed light on experiences and local circumstance, and express views and concerns relevant to health research.

  14. Students' Involvement in Faculty Research: Ethical and Methodological Issues

    Directory of Open Access Journals (Sweden)

    Linda M. Ferguson

    2004-12-01

    Full Text Available Faculty who engage students as participants in their qualitative research often encounter methodological and ethical problems. Ethical issues arise from the fiduciary relationship between faculty and their students, and violations of that relationship occur when the educator has a dual role as researcher with those students. Methodological issues arise from research designs to address these ethical issues. This conflict is particularly evident in faculty research on pedagogy in their own disciplines, for which students are necessary as participants but are captive in the relationship. In this article, the authors explore the issues of double agency when faculty involve students as participants in their research.

  15. Current Research on Effective Classroom Management.

    Science.gov (United States)

    Emmer, Edmund T.

    This presentation provides an overview of research on classroom management, emphasizing results from a program of research conducted at the Research and Development Center for Teacher Education (University of Texas) during the last 5 years. These studies, along with others, provide a basis for describing important dimensions of teacher behavior…

  16. Current trends in free software research

    OpenAIRE

    Navarro Bosch, Ramon; Vila Marta, Sebastià

    2009-01-01

    This report analyzes how scientific research is studying free software. We find which research is being done on free software by looking into scientific journals and conferences publications. The data thus obtained is analized and the most salient trends related to free software discovered. We also reviewed the main works published in each free software research area.

  17. Statistics used in current nursing research.

    Science.gov (United States)

    Zellner, Kathleen; Boerst, Connie J; Tabb, Wil

    2007-02-01

    Undergraduate nursing research courses should emphasize the statistics most commonly used in the nursing literature to strengthen students' and beginning researchers' understanding of them. To determine the most commonly used statistics, we reviewed all quantitative research articles published in 13 nursing journals in 2000. The findings supported Beitz's categorization of kinds of statistics. Ten primary statistics used in 80% of nursing research published in 2000 were identified. We recommend that the appropriate use of those top 10 statistics be emphasized in undergraduate nursing education and that the nursing profession continue to advocate for the use of methods (e.g., power analysis, odds ratio) that may contribute to the advancement of nursing research.

  18. Current status of nuclear physics research

    Energy Technology Data Exchange (ETDEWEB)

    Bertulani, Carlos A. [Department of Physics and Astronomy, Texas A and M University-Commerce (United States); Hussein, Mahir S., E-mail: hussein@if.usp.br [Instituto Tecnologico de Aeronautica (ITA), Sao Jose dos Campos, SP (Brazil). Dept. de Fisica

    2015-12-15

    In this review, we discuss the current status of research in nuclear physics which is being carried out in different centers in the world. For this purpose, we supply a short account of the development in the area which evolved over the last nine decades, since the discovery of the neutron. The evolution of the physics of the atomic nucleus went through many stages as more data became available. We briefly discuss models introduced to discern the physics behind the experimental discoveries, such as the shell model, the collective model, the statistical model, the interacting boson model, etc., some of these models may be seemingly in conflict with each other, but this was shown to be only apparent. The richness of the ideas and abundance of theoretical models attests to the important fact that the nucleus is a really singular system in the sense that it evolves from two-body bound states such as the deuteron, to few-body bound states, such as {sup 4}He, {sup 7}Li, {sup 9}Be, etc. and up the ladder to heavier bound nuclei containing up to more than 200 nucleons. Clearly, statistical mechanics, usually employed in systems with very large number of particles, would seemingly not work for such finite systems as the nuclei, neither do other theories which are applicable to condensed matter. The richness of nuclear physics stems from these restrictions. New theories and models are presently being developed. Theories of the structure and reactions of neutron-rich and proton-rich nuclei, called exotic nuclei, halo nuclei, or Borromean nuclei, deal with the wealth of experimental data that became available in the last 35 years. Furthermore, nuclear astrophysics and stellar and Big Bang nucleosynthesis have become a more mature subject. Due to limited space, this review only covers a few selected topics, mainly those with which the authors have worked on. Our aimed potential readers of this review are nuclear physicists and physicists in other areas, as well as graduate

  19. Current Status of Nuclear Physics Research

    Science.gov (United States)

    Bertulani, Carlos A.; Hussein, Mahir S.

    2015-12-01

    In this review, we discuss the current status of research in nuclear physics which is being carried out in different centers in the world. For this purpose, we supply a short account of the development in the area which evolved over the last nine decades, since the discovery of the neutron. The evolution of the physics of the atomic nucleus went through many stages as more data became available. We briefly discuss models introduced to discern the physics behind the experimental discoveries, such as the shell model, the collective model, the statistical model, the interacting boson model, etc., some of these models may be seemingly in conflict with each other, but this was shown to be only apparent. The richness of the ideas and abundance of theoretical models attests to the important fact that the nucleus is a really singular system in the sense that it evolves from two-body bound states such as the deuteron, to few-body bound states, such as 4He, 7Li, 9Be, etc. and up the ladder to heavier bound nuclei containing up to more than 200 nucleons. Clearly, statistical mechanics, usually employed in systems with very large number of particles, would seemingly not work for such finite systems as the nuclei, neither do other theories which are applicable to condensed matter. The richness of nuclear physics stems from these restrictions. New theories and models are presently being developed. Theories of the structure and reactions of neutron-rich and proton-rich nuclei, called exotic nuclei, halo nuclei, or Borromean nuclei, deal with the wealth of experimental data that became available in the last 35 years. Furthermore, nuclear astrophysics and stellar and Big Bang nucleosynthesis have become a more mature subject. Due to limited space, this review only covers a few selected topics, mainly those with which the authors have worked on. Our aimed potential readers of this review are nuclear physicists and physicists in other areas, as well as graduate students interested in

  20. Increasing User Involvement in Health Care and Health Research Simultaneously

    DEFF Research Database (Denmark)

    Kaltoft, Mette Kjer; Nielsen, Jesper Bo; Salkeld, Glenn

    2014-01-01

    , Comparators, Outcomes, Timings, and Settings (PICOTS) framework. RESULTS: Our underlying hypothesis concerns the person-as-researcher who is equipped with a prescriptive, transparent, expected value-based opinion-an opinion that combines their criterion importance weights with the Best Estimates Available Now...... and democracy. OBJECTIVE: Our Web-based project aims to increase involvement in health care and health research and is presented in the form of an umbrella protocol for a set of project-specific protocols. We conceptualize the person as a researcher engaged in a continual, living, informal "n-of-1"-type study...... the efforts of the "person-as-researcher" as contributing to the total amount of research undertaken in the community, with research not being confined to that undertaken by professional researchers and institutions. This view is fundamentally compatible with both the emancipatory and conventional approaches...

  1. Animal behavioral assessments in current research of Parkinson's disease.

    Science.gov (United States)

    Asakawa, Tetsuya; Fang, Huan; Sugiyama, Kenji; Nozaki, Takao; Hong, Zhen; Yang, Yilin; Hua, Fei; Ding, Guanghong; Chao, Dongman; Fenoy, Albert J; Villarreal, Sebastian J; Onoe, Hirotaka; Suzuki, Katsuaki; Mori, Norio; Namba, Hiroki; Xia, Ying

    2016-06-01

    Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently, clinicians and scientists recognize that many non-motor symptoms are associated with PD. There is an increasing interest in both motor and non-motor symptoms in clinical studies on PD patients and laboratory research on animal models that imitate the pathophysiologic features and symptoms of PD patients. Therefore, appropriate behavioral assessments are extremely crucial for correctly understanding the mechanisms of PD and accurately evaluating the efficacy and safety of novel therapies. This article systematically reviews the behavioral assessments, for both motor and non-motor symptoms, in various animal models involved in current PD research. We addressed the strengths and weaknesses of these behavioral tests and their appropriate applications. Moreover, we discussed potential mechanisms behind these behavioral tests and cautioned readers against potential experimental bias. Since most of the behavioral assessments currently used for non-motor symptoms are not particularly designed for animals with PD, it is of the utmost importance to greatly improve experimental design and evaluation in PD research with animal models. Indeed, it is essential to develop specific assessments for non-motor symptoms in PD animals based on their characteristics. We concluded with a prospective view for behavioral assessments with real-time assessment with mobile internet and wearable device in future PD research.

  2. Some Current Themes in Functional Analysis Research.

    Science.gov (United States)

    Vollmer, Timothy R.; Smith, Richard G.

    1996-01-01

    This article discusses clinical application of functional analysis in developmental disabilities, reviewing issues related to treatment logic and development. The article then approaches functional analysis as a research method, reviewing three areas of research: analysis of diverse response topographies, analysis of basic behavioral processes,…

  3. Neuroimaging for psychotherapy research: current trends.

    Science.gov (United States)

    Weingarten, Carol P; Strauman, Timothy J

    2015-01-01

    This article reviews neuroimaging studies that inform psychotherapy research. An introduction to neuroimaging methods is provided as background for the increasingly sophisticated breadth of methods and findings appearing in psychotherapy research. We compiled and assessed a comprehensive list of neuroimaging studies of psychotherapy outcome, along with selected examples of other types of studies that also are relevant to psychotherapy research. We emphasized magnetic resonance imaging (MRI) since it is the dominant neuroimaging modality in psychological research. We summarize findings from neuroimaging studies of psychotherapy outcome, including treatment for depression, obsessive compulsive disorder (OCD), and schizophrenia. The increasing use of neuroimaging methods in the study of psychotherapy continues to refine our understanding of both outcome and process. We suggest possible directions for future neuroimaging studies in psychotherapy research.

  4. Current developments in toxicological research on arsenic.

    Science.gov (United States)

    Bolt, Hermann M

    2013-01-01

    There is a plethora of recent publications on all aspects relevant to the toxicology of arsenic (As). Over centuries exposures to arsenic continue to be a major public health problem in many countries. In particular, the occurrence of high As concentrations in groundwater of Southeast Asia receives now much attention. Therefore, arsenic is a high-priority matter for toxicological research. Key exposure to As are (traditional) medicines, combustion of As-rich coal, presence of As in groundwater, and pollution due to mining activities. As-induced cardiovascular disorders and carcinogenesis present themselves as a major research focus. The high priority of this issue is now recognized politically in a number of countries, research funds have been made available. Also experimental research on toxicokinetics and toxicodynamics and on modes of toxic action is moving very rapidly. The matter is of high regulatory concern, and effective preventive measures are required in a number of countries.

  5. Loyalty Programmes : Current Knowledge and Research Directions

    NARCIS (Netherlands)

    Dorotic, Matilda; Bijmolt, Tammo H. A.; Verhoef, Peter C.

    2012-01-01

    Loyalty programmes (LPs) have increased in number and popularity, but their effects on customer behaviour remain equivocal, due to a lack of understanding of the drivers of LP effectiveness and insufficient generalizable conclusions across prior studies. This paper synthesizes current knowledge pert

  6. Current trends in chloroplast genome research

    African Journals Online (AJOL)

    USER

    2010-06-14

    Jun 14, 2010 ... organization and promising ability for transgenic expression. Therefore, cpDNA ... highly conserved in size, structure and gene content. (Olmstead and ... contain only 10% of the genes required for fully functional organelle whereas the ... concept (McFadden, 1999; Maliga, 2003; Howe, 2008). Currently 170 ...

  7. Loyalty Programmes : Current Knowledge and Research Directions

    NARCIS (Netherlands)

    Dorotic, Matilda; Bijmolt, Tammo H. A.; Verhoef, Peter C.

    Loyalty programmes (LPs) have increased in number and popularity, but their effects on customer behaviour remain equivocal, due to a lack of understanding of the drivers of LP effectiveness and insufficient generalizable conclusions across prior studies. This paper synthesizes current knowledge

  8. Loyalty Programmes : Current Knowledge and Research Directions

    NARCIS (Netherlands)

    Dorotic, Matilda; Bijmolt, Tammo H. A.; Verhoef, Peter C.

    2012-01-01

    Loyalty programmes (LPs) have increased in number and popularity, but their effects on customer behaviour remain equivocal, due to a lack of understanding of the drivers of LP effectiveness and insufficient generalizable conclusions across prior studies. This paper synthesizes current knowledge pert

  9. Alzheimer Europe's position on involving people with dementia in research through PPI (patient and public involvement)

    DEFF Research Database (Denmark)

    Gove, Dianne; Diaz-Ponce, Ana; Georges, Jean

    2017-01-01

    This paper reflects Alzheimer Europe's position on PPI (patient and public involvement) in the context of dementia research and highlights some of the challenges and potential risks and benefits associated with such meaningful involvement. The paper was drafted by Alzheimer Europe in collaboration...... with members of INTERDEM and the European Working Group of People with Dementia. It has been formally adopted by the Board of Alzheimer Europe and endorsed by the Board of INTERDEM and by the JPND working group 'Dementia Outcome Measures - Charting New Territory'. Alzheimer Europe is keen to promote...

  10. CURRENT STATE OF HISTORIC AND EDUCATIONAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Magsumov Timur Albertovich

    2013-05-01

    Full Text Available In this paper we analyze the results of development of national historic and educational research at the turn of the XXth century; pinpoint obvious success and indicate problems and contradictory areas; give grounding to the development model of the XXth century Russian pedagogy; make suggestions on the strategy and tactics of further development of historic and educational science and suggest areas for further research. They are ‘new social history’ of education, professional education and teacher training, personified microhistory and history of local educational environment, genesis of didactic principles, ethno-pedagogy, country school, pedagogical diagnostics, Orthodox religious education, contemporary history of foreign pedagogy, pedagogical futurology. We prove the need in reassessment of certain studies’ viability. We draw the conclusion that historic and educational knowledge determines areas and instruments to understand the problems of educational issues, their roots and realize the existence of ways to solve them.

  11. Current clinical research in orthodontics: a perspective.

    Science.gov (United States)

    Baumrind, Sheldon

    2006-10-01

    This essay explores briefly the approach of the Craniofacial Research Instrumentation Laboratory to the systematic and rigorous investigation of the usual outcome of orthodontic treatment in the practices of experienced clinicians. CRIL's goal is to produce a shareable electronic database of reliable, valid, and representative data on clinical practice as an aid in the production of an improved environment for truly evidence-based orthodontic treatment.

  12. Integrating Current Meteorological Research Through Club Fundraising

    Science.gov (United States)

    Gill, S. S.; Kauffman, C. M.

    2003-12-01

    Earth science programs whose focus is primarily an undergraduate education do not often have the funding to take students to very many conferences which could expose the student to new research as well as possible graduate programs and employment opportunities. Conferences also give the more enthusiastic and hardworking students a venue in which to present their research to the meteorological community. In addition, the California University services largely lower income counties, which make student attendance at conferences even more difficult even though the student in SW PA may be individually motivated. This issue is compounded by the fact that the Meteorology Concentration within the Earth Science department at Cal U is composed of only two full-time Professors, which limits the amount of research students can be exposed to within a classroom setting. New research ideas presented at conferences are thus an important mechanism for broadening what could be an isolated program. One way in which the meteorology program has circumvented the funding problem to a certain extent is through an active student club. With nearly 60 majors (3/4 of which are active in club activities, the meteorology club is able to execute a variety of fundraising activities. Money that is raised can then request from student services matching funds. Further money is given to clubs, which are very active not only in fundraising, but using that money for academic related activities. For the last 3 years the club budget has been in the neighborhood of \\$4500. The money has then been used to partially finance student registration and accommodation costs making conference attendance much more affordable. Normally 8-16 students attend conferences that they would otherwise not be able to attend without great expense. There are times when more than 16 students wish to attend, but travel arrangements prohibit more than 16. Moreover club money is also use to supplement student costs on a summer

  13. Sustainability in facilities management: an overview of current research

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Sarasoja, Anna-Liisa; Ramskov Galamba, Kirsten

    2016-01-01

    the emerging sub-discipline of sustainable facilities management (SFM) on research, an overview of current studies is needed. The purpose of this literature review is to provide exactly this overview. Design/methodology/approach: This article identifies and examines current research studies on SFM through...... indicated that the current research varies in focus, methodology and application of theory, and it was concluded that the current research primary addresses environmental sustainability, whereas the current research which takes an integrated strategic approach to SFM is limited. The article includes lists...... of reviewed journals and articles to support the further development of SFM in research and practice. Research limitations/implications: The literature review includes literature from 2007 to 2012, to manage the analytical process within the project period. However, with the current categorisation...

  14. Children, Gillick competency and consent for involvement in research.

    Science.gov (United States)

    Hunter, D; Pierscionek, B K

    2007-11-01

    This paper looks at the issue of consent from children and whether the test of Gillick competency, applied in medical and healthcare practice, ought to extend to participation in research. It is argued that the relatively broad usage of the test of Gillick competency in the medical context should not be considered applicable for use in research. The question of who would and could determine Gillick competency in research raises further concerns relating to the training of the researcher to make such a decision as well as to the obvious issue of the researcher's personal interest in the project and possibility of benefiting from the outcome. These could affect the judgment of Gillick competency if the researcher is charged with making this decision. The above notwithstanding, there are two exceptional research situations in which Gillick competency might be legitimately applied: (1) when the research is likely to generate significant advantages for the participants while exposing them to relatively minor risks, and (2) when it is likely to generate great societal benefit, pose minimal risks for the participants and yet raise parental objection. In both cases, to ensure that autonomy is genuinely respected and to protect against personal interest, Gillick competency should be assessed by an individual who has no interest or involvement in the research.

  15. Intelligent multimedia surveillance current trends and research

    CERN Document Server

    Atrey, Pradeep K; Cavallaro, Andrea

    2013-01-01

    Intelligent multimedia surveillance concerns the analysis of multiple sensing inputs including video and audio streams, radio-frequency identification (RFID), and depth data. These data are processed for the automated detection and tracking of people, vehicles, and other objects. The goal is to locate moving targets, to understand their behavior, and to detect suspicious or abnormal activities for crime prevention. Despite its benefits, there is societal apprehension regarding the use of such technology, so an important challenge in this research area is to balance public safety and privacy.

  16. The current status of Kartini research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Tri Wulan Tjiptono; Syarip

    1998-10-01

    The Kartini reactor reached the first criticality on January 25, 1979. In the first three years, the reactor power is limited up to 50 kW thermal power and on July 1, 1982 has been increased to 100 kW. It has been used as experiments facility by researcher of Atomic Energy National Agency and students of the Universities. Three beam tubes used as experiments facilities, the first, is used as a neutron source for H{sub 2}O-Natural Uranium Subcritical Assembly, the second, is developed for neutron radiography facility and the third, is used for gamma radiography facility. The other facilities are rotary rack and two pneumatic transfer systems, one for delayed neutron counting system and the other for the new Neutron Activation Analysis (NAA) facility. The rotary rack used for isotope production for NAA purpose (for long time irradiation), the delayed neutron counting system used for analysis the Uranium contents of the ores and the new NAA is provided for short live elements analysis. In the last three years the Reactor Division has a joint use program with the Nuclear Component and Engineering Center in research reactor instrumentation and control development. (author)

  17. Increasing User Involvement in Health Care and Health Research Simultaneously

    DEFF Research Database (Denmark)

    Kaltoft, Mette Kjer; Nielsen, Jesper Bo; Salkeld, Glenn

    2014-01-01

    , Comparators, Outcomes, Timings, and Settings (PICOTS) framework. RESULTS: Our underlying hypothesis concerns the person-as-researcher who is equipped with a prescriptive, transparent, expected value-based opinion-an opinion that combines their criterion importance weights with the Best Estimates Available Now...... for how well each of the available options performs on each of those outcomes. The hypothesis is that this person-as-researcher is more likely to be able to position themselves as an active participant in a clinical encounter, if they wish, than someone who has engaged with a descriptive decision aid...... and democracy. OBJECTIVE: Our Web-based project aims to increase involvement in health care and health research and is presented in the form of an umbrella protocol for a set of project-specific protocols. We conceptualize the person as a researcher engaged in a continual, living, informal "n-of-1"-type study...

  18. Increasing User Involvement in Health Care and Health Research Simultaneously

    DEFF Research Database (Denmark)

    Kaltoft, Mette Kjer; Nielsen, Jesper Bo; Salkeld, Glenn

    2014-01-01

    for how well each of the available options performs on each of those outcomes. The hypothesis is that this person-as-researcher is more likely to be able to position themselves as an active participant in a clinical encounter, if they wish, than someone who has engaged with a descriptive decision aid...... and democracy. OBJECTIVE: Our Web-based project aims to increase involvement in health care and health research and is presented in the form of an umbrella protocol for a set of project-specific protocols. We conceptualize the person as a researcher engaged in a continual, living, informal "n-of-1"-type study...... of the effects of different actions and interventions on their health, including those implying contact with health care services. We see their research as primarily carried out in order to make better decisions for themselves, but they can offer to contribute the results to the wider population. We see...

  19. Nanofluid technology : current status and future research.

    Energy Technology Data Exchange (ETDEWEB)

    Choi, S. U.-S.

    1998-10-20

    Downscaling or miniaturization has been a recent major trend in modern science and technology. Engineers now fabricate microscale devices such as microchannel heat exchangers, and micropumps that are the size of dust specks. Further major advances would be obtained if the coolant flowing in the microchannels were to contain nanoscale particles to enhance heat transfer. Nanofluid technology will thus be an emerging and exciting technology of the 21st century. This paper gives a brief history of the Advanced Fluids Program at Argonne National Laboratory (ANL), discusses the concept of nanofluids, and provides an overview of the R and D program at ANL on the production, property characterization, and performance of nanofluids. It also describes examples of potential applications and benefits of nanofluids. Finally, future research on the fundamentals and applications of nanofluids is addressed.

  20. A SURVEY OF CURRENT RESEARCH ON CAPTCHA

    Directory of Open Access Journals (Sweden)

    Walid Khalifa Abdullah Hasan

    2016-06-01

    Full Text Available The internet has been playing an increasingly important role in our daily life, with the availability of many web services such as email and search engines. However, these are often threatened by attacks from computer programs such as bots. To address this problem, CAPTCHA (Completely Automated Public Turing Test to Tell Computers and Humans Apart was developed to distinguish between computer programs and human users. Although this mechanism offers good security and limits automatic registration to web services, some CAPTCHAs have several weaknesses which allow hackers to infiltrate the mechanism of the CAPTCHA. This paper examines recent research on various CAPTCHA methods and their categories. Moreover it discusses the weakness and strength of these types.

  1. Participatory action research: involving students in parent education.

    Science.gov (United States)

    Fowler, Cathrine; Wu, Cynthia; Lam, Winsome

    2014-01-01

    Competition for scarce clinical placements has increased requiring new and innovative models to be developed to meet the growing need. A participatory action research project was used to provide a community nursing clinical experience of involvement in parent education. Nine Hong Kong nursing students self-selected to participate in the project to implement a parenting program called Parenting Young Children in a Digital World. Three project cycles were used: needs identification, skills development and program implementation. Students were fully involved in each cycle's planning, action and reflection phase. Qualitative and quantitative data were collected to inform the project. The overall outcome of the project was the provision of a rich and viable clinical placement experience that created significant learning opportunities for the students and researchers. This paper will explore the student's participation in this PAR project as an innovative clinical practice opportunity.

  2. Strategies for involving undergraduates in mentored research (Invited)

    Science.gov (United States)

    Marin-Spiotta, E.

    2013-12-01

    Early engagement in research can transform the undergraduate experience and has a positive effect on minority student recruitment to graduate school. Multiple strategies used to involve undergraduates in research at a large R1 university are presented. During my first four years as an assistant professor, my lab has hosted 14 undergraduates, 9 of them women and 4 of them Hispanic. Institutional support has been critical for undergraduate student involvement. UW supports a research program for incoming underrepresented students. An advantage of this program is very early research participation, with the opportunity for long-term training. One disadvantage is that many first year students have not yet identified their interests. The Biology major also requires students to complete an independent project, which culminates in a research symposium. Competitive research fellowships and grants are available for students to conduct work under faculty mentorship. We have been successful at keeping students on even when their majors are very different from our research discipline, mainly by providing flexibility and a welcoming lab environment. This mentoring culture is strongly fostered by graduate student interest and involvement with all undergraduates as well as active mentor training. By offering multiple pathways for involvement, we can accommodate students' changing schedules and priorities as well as changing lab needs. Students can volunteer, receive course credit, conduct an independent project or honors thesis, contribute to an existing project, do lab work or write a literature review, work with one mentor or on multiple projects. We often provide employment over the summer and subsequent semesters for continuing students. Some will increase their commitment over time and work more closely with me. Others reduce down to a few hours a week as they gain experience elsewhere. Most students stay multiple semesters and multiple years because they 'enjoy being in the

  3. Ethical Conduct in Research Involving Human Beings In Brazil

    Science.gov (United States)

    Novaes, Maria Rita Garbi; Guilhem, Dirce; Lolas, Fernando

    2010-01-01

    Objective Diagnose ethical conduct in research involving human beings in Brazil and the last 10 years of activity by the Human Research Ethics Committee of the Health Department - Federal District - CEP/SES/DF. Methods This work was based on a documentary research, descriptive and retrospective. It examined the database containing records of cases brought before the CEP/SES/DF, corresponding the period of June 1997 to December 2007. Results were generated in Excel program, version 2007. Results CEP/SES/DF has presented increasing number of research projects submitted to appreciation (n = 1129), composing: 90.4% approved 1.7% disapproved, 7.4% removed/filed and 0.5% excluded. Of these projects, 83% belonged to Group III, 18% multi-centered projects and 10% protocols with foreign participation. Time for approval has decreased over the years (30 to 60 days). Frequent pendencies: End of Free and Informed Consent (30%), Cover Sheet (25%), Methodology (20%), Curriculum vitae (12%), Budget (9%), and Others (4%). Conclusion The assessment of the CEP/SES/DF activities, during a ten-year period has shown its commitment to the legitimacy of research ethics review and scientific production SES/DF. There were some weaknesses such as difficulty in monitoring the accompaniment of the research; interruption of works due to adverse drug reaction; gaps or errors in the protocol submitted by the researcher. These situations are the achieving targets for the elaboration of specific criteria. PMID:20981277

  4. The International Permafrost Association: current initiatives for cryospheric research

    Science.gov (United States)

    Schollaen, Karina; Lewkowicz, Antoni G.; Christiansen, Hanne H.; Romanovsky, Vladimir E.; Lantuit, Hugues; Schrott, Lothar; Sergeev, Dimitry; Wei, Ma

    2015-04-01

    The International Permafrost Association (IPA), founded in 1983, has as its objectives to foster the dissemination of knowledge concerning permafrost and to promote cooperation among persons and national or international organizations engaged in scientific investigation and engineering work on permafrost. The IPA's primary responsibilities are convening International Permafrost Conferences, undertaking special projects such as preparing databases, maps, bibliographies, and glossaries, and coordinating international field programs and networks. Membership is through adhering national or multinational organizations or as individuals in countries where no Adhering Body exists. The IPA is governed by its Executive Committee and a Council consisting of representatives from 26 Adhering Bodies having interests in some aspect of theoretical, basic and applied frozen ground research, including permafrost, seasonal frost, artificial freezing and periglacial phenomena. This presentation details the IPA core products, achievements and activities as well as current projects in cryospheric research. One of the most important core products is the circumpolar permafrost map. The IPA also fosters and supports the activities of the Global Terrestrial Network on Permafrost (GTN-P) sponsored by the Global Terrestrial Observing System, GTOS, and the Global Climate Observing System, GCOS, whose long-term goal is to obtain a comprehensive view of the spatial structure, trends, and variability of changes in the active layer thickness and permafrost temperature. A further important initiative of the IPA are the biannually competitively-funded Action Groups which work towards the production of well-defined products over a period of two years. Current IPA Action Groups are working on highly topical and interdisciplinary issues, such as the development of a regional Palaeo-map of Permafrost in Eurasia, the integration of multidisciplinary knowledge about the use of thermokarst and permafrost

  5. Current Issues in LPP Research and Their Impact on Society

    Science.gov (United States)

    Darquennes, Jeroen

    2013-01-01

    After a very broad description of what language policy and planning is about this paper presents an overview of some of the current preoccupations of researchers focusing on language policy and planning as one of the blooming fields of applied linguistics. The current issues in language policy and planning research that are dealt with include…

  6. Trends in research involving human beings in Brazil.

    Science.gov (United States)

    Silva, Ricardo Eccard da; Novaes, Maria Rita Carvalho; Pastor, Elza Martínez; Barragan, Elena; Amato, Angélica Amorim

    2015-02-01

    Developing countries have experienced a dramatic increase in the number of clinical studies in the last decades. The aim of this study was to describe 1) the number of clinical trials submitted to the Brazilian Health Surveillance Agency (Agência Nacional de Vigilância Sanitária, Anvisa) from 2007 to 2012 and the number of human-subject research projects approved by research ethics committees (RECs) and the National Research Ethics Committee (Comissão Nacional de Ética em Pesquisa, CONEP) in Brazil from 2007 to 2011 and 2) the diseases most frequently studied in Brazilian states in clinical trials approved in the country from 2009 to 2012, based on information from an Anvisa databank. Two databases were used: 1) the National Information System on Research Ethics Involving Human Beings (Sistema Nacional de Informação Sobre Ética em Pesquisa envolvendo Seres Humanos, SISNEP) and 2) Anvisa's Clinical Research Control System (Sistema de Controle de Pesquisa Clínica, SCPC). Data from the SCPC indicated an increase of 32.7% in the number of clinical trials submitted to Anvisa, and data from the SISNEP showed an increase of 69.9% in those approved by RECs and CONEP (from 18 160 in 2007 to 30 860 in 2011). Type 2 diabetes (26.0%) and breast cancer (20.5%)-related to the main causes of mortality in Brazil-were the two most frequently studied diseases. The so-called “neglected diseases,” such as dengue fever, were among the least studied diseases in approved clinical trials, despite their significant impact on social, economic, and health indicators in Brazil. Overall, the data indicated 1) a clear trend toward more research involving human beings in Brazil, 2) good correspondence between diseases most studied in clinical trials approved by Anvisa and the main causes of death in Brazil, and 3) a low level of attention to neglected diseases, an issue that should be considered in setting future research priorities, given their socioeconomic and health effects.

  7. A Research Framework for Understanding the Practical Impact of Family Involvement in the Juvenile Justice System: The Juvenile Justice Family Involvement Model.

    Science.gov (United States)

    Walker, Sarah Cusworth; Bishop, Asia S; Pullmann, Michael D; Bauer, Grace

    2015-12-01

    Family involvement is recognized as a critical element of service planning for children's mental health, welfare and education. For the juvenile justice system, however, parents' roles in this system are complex due to youths' legal rights, public safety, a process which can legally position parents as plaintiffs, and a historical legacy of blaming parents for youth indiscretions. Three recent national surveys of juvenile justice-involved parents reveal that the current paradigm elicits feelings of stress, shame and distrust among parents and is likely leading to worse outcomes for youth, families and communities. While research on the impact of family involvement in the justice system is starting to emerge, the field currently has no organizing framework to guide a research agenda, interpret outcomes or translate findings for practitioners. We propose a research framework for family involvement that is informed by a comprehensive review and content analysis of current, published arguments for family involvement in juvenile justice along with a synthesis of family involvement efforts in other child-serving systems. In this model, family involvement is presented as an ascending, ordinal concept beginning with (1) exclusion, and moving toward climates characterized by (2) information-giving, (3) information-eliciting and (4) full, decision-making partnerships. Specific examples of how courts and facilities might align with these levels are described. Further, the model makes predictions for how involvement will impact outcomes at multiple levels with applications for other child-serving systems.

  8. Embedding a Recovery Orientation into Neuroscience Research: Involving People with a Lived Experience in Research Activity.

    Science.gov (United States)

    Stratford, Anthony; Brophy, Lisa; Castle, David; Harvey, Carol; Robertson, Joanne; Corlett, Philip; Davidson, Larry; Everall, Ian

    2016-03-01

    This paper highlights the importance and value of involving people with a lived experience of mental ill health and recovery in neuroscience research activity. In this era of recovery oriented service delivery, involving people with the lived experience of mental illness in neuroscience research extends beyond their participation as "subjects". The recovery paradigm reconceptualises people with the lived experience of mental ill health as experts by experience. To support this contribution, local policies and procedures, recovery-oriented training for neuroscience researchers, and dialogue about the practical applications of neuroscience research, are required.

  9. Current status and future directions of research on facial attractiveness

    National Research Council Canada - National Science Library

    Kościński, Krzysztof

    2009-01-01

    The aim of the present paper was to evaluate the current state of knowledge on the perception of facial attractiveness and to assess the opportunity for research on poorly explored issues regarding facial preferences...

  10. Service user involvement in nursing, midwifery and health visiting research: a review of evidence and practice.

    Science.gov (United States)

    Smith, Elizabeth; Ross, Fiona; Donovan, Sheila; Manthorpe, Jill; Brearley, Sally; Sitzia, John; Beresford, Peter

    2008-02-01

    In the UK policy recommends that service users (patients, carers and the public) should be involved in all publicly funded health and social care research. However, little is known about which approaches work best in different research contexts and why. The purpose of this paper is to explain some of the theoretical limitations to current understandings of service user involvement and to provide some suggestions for theory and methods development. This paper draws upon findings from a review of the research 'evidence' and current practice on service user involvement in the design and undertaking of nursing, midwifery and health visiting research. A multi-method review was commissioned by the NHS Service Delivery and Organisation (SDO) Research and Development Programme. The timeframe was April 2004-March 2005. The full report (Ref: SDO/69/2003) and supplementary bibliography are available from: http://www.sdo.lshtm.ac.uk. REVIEW METHODS/DATA: Initial searches of the health and social care literature and consultations with researchers were used to develop a broad definition of the topic area. A service user reference group (26 members) worked with the project team to refine the scope of the review, to set inclusion criteria and develop a framework for the analysis. Systematic searches of the literature were undertaken online and through library stacks (345 relevant documents were identified). Ongoing and recently completed studies that had involved service users were identified through online databases (34 studies) and through a national consultation exercise (17 studies). Selected studies were followed up using telephone interviews (n=11). Members of the service user reference group worked with the research team to advise on key messages for dissemination to different audiences. Information was gained about contextual factors, drivers, concepts, approaches and outcomes of service user involvement in nursing, midwifery and health visiting research, as well as

  11. Current Research on the Relative Effectiveness of Selected Media Characteristics.

    Science.gov (United States)

    Gulliford, Nancy L.

    The literature of research and theory on media, the psychology of learning, and the technology of instruction is reviewed. The focus is on discovering what is currently known about the intersection of these fields. Current thoughts and discoveries about brain structure and processing are discussed. The management of learning as a system is another…

  12. The Association of Current Violence from Adult Family Members with Adolescent Bullying Involvement and Suicidal Feelings.

    Science.gov (United States)

    Fujikawa, Shinya; Ando, Shuntaro; Shimodera, Shinji; Koike, Shinsuke; Usami, Satoshi; Toriyama, Rie; Kanata, Sho; Sasaki, Tsukasa; Kasai, Kiyoto; Okazaki, Yuji; Nishida, Atsushi

    2016-01-01

    Although several studies have reported that child physical abuse increased the risk for bullying involvement, the effect of current violence from adult family members (CVA) on bullying involvement and suicidal feelings among adolescents has not been sufficiently examined. This study investigated the association of CVA with adolescent bullying involvement and the interaction effect of CVA and bullying involvement on suicidal feelings. This cross-sectional study used data from a school-based survey with a general population of adolescents (grades 7 to 12). Data were collected using a self-report questionnaire completed by 17,530 students. Logistic regression analyses were performed to explore the association of CVA with adolescent bullying involvement and suicidal feelings. The overall response rate was 90.2%. The odds of students being characterized as bullies, victims, and bully-victims were higher among adolescents with CVA than without CVA (odds ratios (OR) = 2.9, 95% confidence interval (CI), [2.3-3.7], 4.6 [3.6-5.8], and 5.8 [4.4-7.6], respectively). Both CVA (OR = 3.4 [95% CI 2.7-4.3]) and bullying (bullies, victims, and bully-victims; OR = 2.0 [95% CI 1.6-2.6], 4.0 [3.1-5.1], 4.1 [3.0-5.6], respectively), were associated with increased odds of current suicidal feelings after adjusting for confounding factors. Furthermore, positive additive effects of CVA and all three types of bullying involvement on suicidal feelings were found. For example, bully-victims with CVA had about 19-fold higher odds of suicidal feelings compared with uninvolved adolescents without CVA. This study, although correlational, suggested that CVA avoidance might prevent bullying involvement and suicidal feelings in adolescents.

  13. The Association of Current Violence from Adult Family Members with Adolescent Bullying Involvement and Suicidal Feelings

    Science.gov (United States)

    Shimodera, Shinji; Koike, Shinsuke; Usami, Satoshi; Toriyama, Rie; Kanata, Sho; Sasaki, Tsukasa; Kasai, Kiyoto; Okazaki, Yuji; Nishida, Atsushi

    2016-01-01

    Although several studies have reported that child physical abuse increased the risk for bullying involvement, the effect of current violence from adult family members (CVA) on bullying involvement and suicidal feelings among adolescents has not been sufficiently examined. This study investigated the association of CVA with adolescent bullying involvement and the interaction effect of CVA and bullying involvement on suicidal feelings. This cross-sectional study used data from a school-based survey with a general population of adolescents (grades 7 to 12). Data were collected using a self-report questionnaire completed by 17,530 students. Logistic regression analyses were performed to explore the association of CVA with adolescent bullying involvement and suicidal feelings. The overall response rate was 90.2%. The odds of students being characterized as bullies, victims, and bully-victims were higher among adolescents with CVA than without CVA (odds ratios (OR) = 2.9, 95% confidence interval (CI), [2.3–3.7], 4.6 [3.6–5.8], and 5.8 [4.4–7.6], respectively). Both CVA (OR = 3.4 [95% CI 2.7–4.3]) and bullying (bullies, victims, and bully-victims; OR = 2.0 [95% CI 1.6–2.6], 4.0 [3.1–5.1], 4.1 [3.0–5.6], respectively), were associated with increased odds of current suicidal feelings after adjusting for confounding factors. Furthermore, positive additive effects of CVA and all three types of bullying involvement on suicidal feelings were found. For example, bully-victims with CVA had about 19-fold higher odds of suicidal feelings compared with uninvolved adolescents without CVA. This study, although correlational, suggested that CVA avoidance might prevent bullying involvement and suicidal feelings in adolescents. PMID:27711150

  14. Involving Clients in Programme Evaluation and Research: A New Methodology for Occupational Therapy.

    Science.gov (United States)

    Clark, Carrie; And Others

    1993-01-01

    Reviews the relationship between occupational therapy and client involvement, examines the rationale for involving clients in program evaluation and research, and discusses how clients are involved in evaluation and research in today's mental health care setting. (Author)

  15. Current status of auditory aging and anti-aging research.

    Science.gov (United States)

    Ruan, Qingwei; Ma, Cheng; Zhang, Ruxin; Yu, Zhuowei

    2014-01-01

    The development of presbycusis, or age-related hearing loss, is determined by a combination of genetic and environmental factors. The auditory periphery exhibits a progressive bilateral, symmetrical reduction of auditory sensitivity to sound from high to low frequencies. The central auditory nervous system shows symptoms of decline in age-related cognitive abilities, including difficulties in speech discrimination and reduced central auditory processing, ultimately resulting in auditory perceptual abnormalities. The pathophysiological mechanisms of presbycusis include excitotoxicity, oxidative stress, inflammation, aging and oxidative stress-induced DNA damage that results in apoptosis in the auditory pathway. However, the originating signals that trigger these mechanisms remain unclear. For instance, it is still unknown whether insulin is involved in auditory aging. Auditory aging has preclinical lesions, which manifest as asymptomatic loss of periphery auditory nerves and changes in the plasticity of the central auditory nervous system. Currently, the diagnosis of preclinical, reversible lesions depends on the detection of auditory impairment by functional imaging, and the identification of physiological and molecular biological markers. However, despite recent improvements in the application of these markers, they remain under-utilized in clinical practice. The application of antisenescent approaches to the prevention of auditory aging has produced inconsistent results. Future research will focus on the identification of markers for the diagnosis of preclinical auditory aging and the development of effective interventions.

  16. Alcohol and NMDA Receptor: Current research and future direction

    Directory of Open Access Journals (Sweden)

    Raman eChandrasekar

    2013-05-01

    Full Text Available The brain is one of the major targets of alcohol actions. Most of the excitatory synaptic transmission in the central nervous system is mediated by NMDA receptors. However, one of the most devastating effects of alcohol leads to brain shrinkage, loss of nerve cells at specific regions through a mechanism involving excitotoxicity, oxidative stress. Earlier studies have indicated that chronic exposure to ethanol both in vivo and in vitro, increases NR1 and NR2B gene expression and their polypeptide levels. The effect of alcohol and molecular changes on the regulatory process, which modulates NMDAR functions including factors altering transcription, translation, post-translational modifications and protein expression, as well as those influencing their interactions with different regulatory proteins (downstream effectors are incessantly increasing at the cellular level. Further, I discuss the various genetically altered mice approaches that have been used to study NMDA receptor subunits and their functional implication. In a recent countable review, epigenetic dimension (i.e., histone modification-induced chromatin remodeling and DNA methylation, in the process of alcohol related neuroadapation is one of the key molecular mechanisms in alcohol mediated NMDAR alteration. Here, I provide a recount on what has already been achieved, current trends and how the future research/studies of the NMDA receptor might lead to even greater engagement with many possible new insights into the neurobiology and treatment of alcoholism.

  17. Alcohol and NMDA receptor: current research and future direction.

    Science.gov (United States)

    Chandrasekar, Raman

    2013-01-01

    The brain is one of the major targets of alcohol actions. Most of the excitatory synaptic transmission in the central nervous system is mediated by N-methyl-D-aspartate (NMDA) receptors. However, one of the most devastating effects of alcohol leads to brain shrinkage, loss of nerve cells at specific regions through a mechanism involving excitotoxicity, oxidative stress. Earlier studies have indicated that chronic exposure to ethanol both in vivo and in vitro, increases NR1 and NR2B gene expression and their polypeptide levels. The effect of alcohol and molecular changes on the regulatory process, which modulates NMDAR functions including factors altering transcription, translation, post-translational modifications, and protein expression, as well as those influencing their interactions with different regulatory proteins (downstream effectors) are incessantly increasing at the cellular level. Further, I discuss the various genetically altered mice approaches that have been used to study NMDA receptor subunits and their functional implication. In a recent countable review, epigenetic dimension (i.e., histone modification-induced chromatin remodeling and DNA methylation, in the process of alcohol related neuroadaptation) is one of the key molecular mechanisms in alcohol mediated NMDAR alteration. Here, I provide a recount on what has already been achieved, current trends and how the future research/studies of the NMDA receptor might lead to even greater engagement with many possible new insights into the neurobiology and treatment of alcoholism.

  18. Current research projects on traffic conflicts technique studies.

    NARCIS (Netherlands)

    Hondel, M. van den & and Kraay, J.H.

    1979-01-01

    A review of current research concerning the development, evaluation and use of the traffic conflicts technique is presented. The 32 studies, selected from the IRRD data base, are listed alphabetically by names of countries and under countries by names of research organizations. The IRRD descriptions

  19. Educational Research in Mainland China: Current Situation and Developmental Trends

    Science.gov (United States)

    Sun, Miantao

    2011-01-01

    The influence of Confucian culture in Chinese Mainland China is reflected in the current situation and contextual trends of educational research content of educational thought of Confucianism, educational issues grounded on theoretical views of Confucianism, and the influence of the inclusiveness of Confucianism. In terms of research method, the…

  20. Current status and future research in motion planning

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Y.K.

    1995-07-01

    There have been numerous research efforts in the field of motion planning, resulting in many theoretical and practical results. We review the current status of existing motion planning algorithms, evaluate their completeness and efficiencies on modern computers, and suggest fruitful future research directions.

  1. Educational Research in Mainland China: Current Situation and Developmental Trends

    Science.gov (United States)

    Sun, Miantao

    2011-01-01

    The influence of Confucian culture in Chinese Mainland China is reflected in the current situation and contextual trends of educational research content of educational thought of Confucianism, educational issues grounded on theoretical views of Confucianism, and the influence of the inclusiveness of Confucianism. In terms of research method, the…

  2. Image Information Retrieval: An Overview of Current Research

    Directory of Open Access Journals (Sweden)

    Abby A. Goodrum

    2000-01-01

    Full Text Available This paper provides an overview of current research in image information retrieval and provides an outline of areas for future research. The approach is broad and interdisciplinary and focuses on three aspects of image research (IR: text-based retrieval, content-based retrieval, and user interactions with image information retrieval systems. The review concludes with a call for image retrieval evaluation studies similar to TREC.

  3. Image Information Retrieval: An Overview of Current Research

    OpenAIRE

    Abby A. Goodrum

    2000-01-01

    This paper provides an overview of current research in image information retrieval and provides an outline of areas for future research. The approach is broad and interdisciplinary and focuses on three aspects of image research (IR): text-based retrieval, content-based retrieval, and user interactions with image information retrieval systems. The review concludes with a call for image retrieval evaluation studies similar to TREC.

  4. Research Reproducibility in Geosciences: Current Landscape, Practices and Perspectives

    Science.gov (United States)

    Yan, An

    2016-04-01

    Reproducibility of research can gauge the validity of its findings. Yet currently we lack understanding of how much of a problem research reproducibility is in geosciences. We developed an online survey on faculty and graduate students in geosciences, and received 136 responses from research institutions and universities in Americas, Asia, Europe and other parts of the world. This survey examined (1) the current state of research reproducibility in geosciences by asking researchers' experiences with unsuccessful replication work, and what obstacles that lead to their replication failures; (2) the current reproducibility practices in community by asking what efforts researchers made to try to reproduce other's work and make their own work reproducible, and what the underlying factors that contribute to irreproducibility are; (3) the perspectives on reproducibility by collecting researcher's thoughts and opinions on this issue. The survey result indicated that nearly 80% of respondents who had ever reproduced a published study had failed at least one time in reproducing. Only one third of the respondents received helpful feedbacks when they contacted the authors of a published study for data, code, or other information. The primary factors that lead to unsuccessful replication attempts are insufficient details of instructions in published literature, and inaccessibility of data, code and tools needed in the study. Our findings suggest a remarkable lack of research reproducibility in geoscience. Changing the incentive mechanism in academia, as well as developing policies and tools that facilitate open data and code sharing are the promising ways for geosciences community to alleviate this reproducibility problem.

  5. Current states and perspectives of Czech educational research

    Directory of Open Access Journals (Sweden)

    Tomáš Janík

    2010-06-01

    Full Text Available The aim of the review study is to evaluate the current state of Czech educationalresearch and to offer possibilities of its further development. The paper has threeparts. In the first part, the author presents the context of the topic: the current changesin the financing of research and development in the Czech Republic; the avoiding ofthe term (social science is discussed along with the issue of institutional financing ofresearch and the various presently up-to-date methodologies of quality assessment inresearch. In the second part, the author analyses the current state of Czech educationalresearch – previous analyses of J. Pr°ucha, J. Mareš and E. Walterová and those carriedout by the Educational Research Centre are briefly summarised. In the third part, possibilitiesof further development of Czech educational research are offered. Developinga knowledge base of educational sciences is used as an example. First the nature andsubject of knowledge that is produced by research is analysed, then the difference betweenpedagogical research and research in education is discussed. Towards the end,relevant approaches are discussed along with research areas and types of knowledgeacquired by research.

  6. Clinical research data sharing: what an open science world means for researchers involved in evidence synthesis.

    Science.gov (United States)

    Ross, Joseph S

    2016-09-20

    The International Committee of Medical Journal Editors (ICMJE) recently announced a bold step forward to require data generated by interventional clinical trials that are published in its member journals to be responsibly shared with external investigators. The movement toward a clinical research culture that supports data sharing has important implications for the design, conduct, and reporting of systematic reviews and meta-analyses. While data sharing is likely to enhance the science of evidence synthesis, facilitating the identification and inclusion of all relevant research, it will also pose key challenges, such as requiring broader search strategies and more thorough scrutiny of identified research. Furthermore, the adoption of data sharing initiatives by the clinical research community should challenge the community of researchers involved in evidence synthesis to follow suit, including the widespread adoption of systematic review registration, results reporting, and data sharing, to promote transparency and enhance the integrity of the research process.

  7. Current Relevance of Zetetics to Library Research and Library Instruction.

    Science.gov (United States)

    Davis, Marta A.; Davis, Harry O.

    1996-01-01

    Explains zetetics which involve theories of research and epistemology and discusses its relevance to library science. Topics include library literacy, and the use of an information matrix to help library patrons understand what information they have and what they need to find. (Author/LRW)

  8. The Development and Current State of Translation Process Research

    DEFF Research Database (Denmark)

    Lykke Jakobsen, Arnt

    2014-01-01

    The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer to a spe......The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer...... to a special descriptive, empirical, experimental approach to translation studies based on close, technology-supported observation of translational (micro)behaviour. Fundamentally, TPR is based on software which logs a translator’s keystrokes on a computer keyboard in time in combination with an eyetracker...

  9. Curating research data a handbook of current practice

    CERN Document Server

    Johnston, Lisa R

    2017-01-01

    Curating Research Data, Volume Two: A Handbook of Current Practice guides you across the data lifecycle through the practical strategies and techniques for curating research data in a digital repository setting. The data curation steps for receiving, appraising, selecting, ingesting, transforming, describing, contextualizing, disseminating, and preserving digital research data are each explored, and then supplemented with detailed case studies written by more than forty international practitioners from national, disciplinary, and institutional data repositories. The steps in this volume detail the sequential actions that you might take to curate a data set from receiving the data (Step 1) to eventual reuse (Step 8). Data curators, archivists, research data management specialists, subject librarians, institutional repository managers, and digital library staff will benefit from these current and practical approaches to data curation.

  10. [Physiotherapeutic care marketing research: current state-of-the art].

    Science.gov (United States)

    Babaskin, D V

    2011-01-01

    Successful introduction of modern technologies into the national health care systems strongly depends on the current pharmaceutical market situation. The present article is focused on the peculiarities of marketing research with special reference to physiotherapeutic services and commodities. Analysis of the structure and sequence of marketing research processes is described along with the methods applied for the purpose including their support by the use of Internet resources and technologies.

  11. Current advances in DNA repair: regulation of enzymes and pathways involved in maintaining genomic stability.

    Science.gov (United States)

    Neher, Tracy M; Turchi, John J

    2011-06-15

    Novel discoveries in the DNA repair field have lead to continuous and rapid advancement of our understanding of not only DNA repair but also DNA replication and recombination. Research in the field transcends numerous areas of biology, biochemistry, physiology, and medicine, making significant connections across these broad areas of study. From early studies conducted in bacterial systems to current analyses in eukaryotic systems and human disease, the innovative research into the mechanisms of repair machines and the consequences of ineffective DNA repair has impacted a wide scientific community. This Forum contains a select mix of primary research articles in addition to a number of timely reviews covering a subset of DNA repair pathways where recent advances and novel discoveries are improving our understanding of DNA repair, its regulation, and implications to human disease.

  12. Current research status of immunology in the genomic era

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    This review updates the current status of immunology research under the influence of genomics,both conceptually and technologically.It particularly highlights the advantages of employing the high-throughput and large-scale technology,the large genomic database,and bioinformatic power in the immunology research.The fast development in the fields of basic immunology,clinical immunology(tumor and infectious immunology) and vaccine designing is illustrated with respect to the successful usage of genomic strategy.We also speculate the future research directions of immunology in the era of genomics and post-genomics.

  13. Current research status of immunology in the genomic era

    Institute of Scientific and Technical Information of China (English)

    LI HaoWen; LI dinZhi; ZHAO GuoPing; WANG Ying

    2009-01-01

    This review updates the current status of immunology research under the influence of genomics, both conceptually and technologically. It particularly highlights the advantages of employing the high-throughput and large-scale technology, the large genomic database, and bioinformatic power in the immunology research. The fast development in the fields of basic immunology, clinical immunology (tumor and infectious immunology) and vaccine designing is illustrated with respect to the successful usage of genomic strategy. We also speculate the future research directions of immunology in the era of genomics and post-genomics.

  14. Changing Currents in Second Language Writing Research: A Colloquium.

    Science.gov (United States)

    Matsuda, Paul Kei; Canagarajah, A. Suresh; Harklau, Linda; Hyland, Ken; Warschauer, Mark

    2003-01-01

    This article is based on an invited colloqium on second language (L) writing presented at the 200 meeting of the American Association for Applied Linguistics. The colloquium featured five second language writing researchers two discussed some of the important currents that have shaped the field of second language writing. (Author/VWL)

  15. Current Status and Advancements in Research of Plantation Nutrient Cycling

    Institute of Scientific and Technical Information of China (English)

    LI Run; ZHANG Changshun; SUN Yongyu

    2006-01-01

    This paper introduces concepts and current research status of plantation nutrients cyclings, and analyzes main contents of plantation nutrients cycling as nutrients contents, accumulation and distribution of nutrients elements, understory species and forest litter. At the same time, the paper summarizes the problems in plantation nutrients cycling and its prospects.

  16. Communicative Language Testing: Current Issues and Future Research

    Science.gov (United States)

    Harding, Luke

    2014-01-01

    This article discusses a range of current issues and future research possibilities in Communicative Language Testing (CLT) using, as its departure point, the key questions which emerged during the CLT symposium at the 2010 Language Testing Forum. The article begins with a summary of the 2010 symposium discussion in which three main issues related…

  17. Lubbock Gin Lab - Current Research and Leaf Grade Issues

    Science.gov (United States)

    This presentation was given to a group of cotton gin managers and allied industry reps. Approximately 100 attendees were in the audience. A discussion of the current research conducted at the USDA ARS CPPRU Ginning Laboratory in Lubbock, TX was given along with a discussion of leaf grade issues and ...

  18. Cheerleading and Cynicism of Effective Mentoring in Current Empirical Research

    Science.gov (United States)

    Crutcher, Paul A.; Naseem, Samina

    2016-01-01

    This article presents the results of a review of current empirical research of effective practices in teacher mentoring. Compiling literature published since 2000 in peer-reviewed journals, we examine arguments for mentoring practices to improve teacher candidate and novice teacher experiences and skills. The emergent "effective"…

  19. Students' Involvement in Faculty Research: Ethical and Methodological Issues

    OpenAIRE

    Ferguson, Linda M; Olive Yonge; Florence Myrick

    2004-01-01

    Faculty who engage students as participants in their qualitative research often encounter methodological and ethical problems. Ethical issues arise from the fiduciary relationship between faculty and their students, and violations of that relationship occur when the educator has a dual role as researcher with those students. Methodological issues arise from research designs to address these ethical issues. This conflict is particularly evident in faculty research on pedagogy in their own disc...

  20. Environmental Health Research Involving Human Subjects: Ethical Issues

    Directory of Open Access Journals (Sweden)

    David B. Resnik

    2008-01-01

    Full Text Available This article reviews some of the ethical issues that arise in environmental health research with human subjects, such as minimizing risks to subjects, balancing benefits and risks in research, intentional exposure studies with human subjects, protecting third parties in research, informing subjects about environmental hazards, communicating health information to subjects, and protecting privacy and confidentiality.

  1. 'Now we call it research': participatory health research involving marginalized women who use drugs.

    Science.gov (United States)

    Salmon, Amy; Browne, Annette J; Pederson, Ann

    2010-12-01

    In this paper, we discuss and analyse the strategies employed and challenges encountered when conducting a recent feminist participatory action research study with highly marginalized women who were illicit drug users in an inner city area of Vancouver, Canada. Through an analysis of the political economy of participatory praxis within current neoliberal contexts, we focus on three main areas: (i) reconceptualizing the pragmatics of participation; (ii) the microeconomic implications of participatory research, including ethical issues in payment for research participation; and (iii) the value and limits of using research as a tool for activism and empowerment. We conclude with a brief discussion of what we see to be some of the most salient social justice implications arising from feminist and participatory approaches to health research within neoliberal political spaces.

  2. The current status of research on resources recycling in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Seung-Hee; Kuh, Sung-Eun; Kim, Dong-Su [Ewha Womans University, Seoul (Korea)

    1999-03-31

    The current domestic research status for resources recycling has been reviewed by surveying the technical and review papers reported to some academic journals. The surveyed articles were classified based upon several categories, including recycling fields according to the kinds of recyclable materials, applied recycling technologies, organizations where the research was conducted, and references according to publication year and region. The survey showed that the recycling of metallurgical waste is being studied most actively. Also, the investigation of fly ash recycling is surveyed to be actively conducted. In the aspect of recycling technologies, chemical technologies are shown to be more widely applied than physical ones. For research-conducting organizations, academic institutes have been more active in the research of recycling field compared with national/private research institutes and industries. In the reference survey, English-written articles and the articles published between 1991-1995 period are shown to be most referred. (author). 6 refs., 7 tabs., 8 figs.

  3. Consciousness and working memory: Current trends and research perspectives.

    Science.gov (United States)

    Velichkovsky, Boris B

    2017-07-27

    Working memory has long been thought to be closely related to consciousness. However, recent empirical studies show that unconscious content may be maintained within working memory and that complex cognitive computations may be performed on-line. This promotes research on the exact relationships between consciousness and working memory. Current evidence for working memory being a conscious as well as an unconscious process is reviewed. Consciousness is shown to be considered a subset of working memory by major current theories of working memory. Evidence for unconscious elements in working memory is shown to come from visual masking and attentional blink paradigms, and from the studies of implicit working memory. It is concluded that more research is needed to explicate the relationship between consciousness and working memory. Future research directions regarding the relationship between consciousness and working memory are discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Animal models of frailty: current applications in clinical research.

    Science.gov (United States)

    Kane, Alice E; Hilmer, Sarah N; Mach, John; Mitchell, Sarah J; de Cabo, Rafael; Howlett, Susan E

    2016-01-01

    The ethical, logistical, and biological complications of working with an older population of people inherently limits clinical studies of frailty. The recent development of animal models of frailty, and tools for assessing frailty in animal models provides an invaluable opportunity for frailty research. This review summarizes currently published animal models of frailty including the interleukin-10 knock-out mouse, the mouse frailty phenotype assessment tool, and the mouse clinical frailty index. It discusses both current and potential roles of these models in research into mechanisms of frailty, interventions to prevent/delay frailty, and the effect of frailty on outcomes. Finally, this review discusses some of the challenges and opportunities of translating research findings from animals to humans.

  5. 78 FR 52777 - Implementation of the Revised International Guiding Principles for Biomedical Research Involving...

    Science.gov (United States)

    2013-08-26

    ... Principles for Biomedical Research Involving Animals SUMMARY: The National Institutes of Health (NIH) is... International Guiding Principles for Biomedical Research Involving Animals (``Guiding Principles''). The NIH is... ) that commits the institution to follow the International Guiding Principles for Biomedical...

  6. Active involvement of people with intellectual disabilities in health research - A structured literature review.

    Science.gov (United States)

    Frankena, Tessa Kim; Naaldenberg, Jenneken; Cardol, Mieke; Linehan, Christine; van Schrojenstein Lantman-de Valk, Henny

    2015-01-01

    Actively involving people with intellectual disabilities (ID) in health research, also known as inclusive health research, is increasingly popular. Currently, insight into experiences of this type of research is scarce. To gain insight into this topic, a structured literature review was conducted focussing on (1) existing theories, (2) inclusive methods, (3) added value and (4) barriers and facilitators. Literature published between January 2000 and January 2014 was included covering keywords related to ID and inclusive health research. Searches were performed in Pubmed, CINAHL, PsycINFO, EMBASE and MEDLINE databases, resulting in 26 included papers. Papers were quality assessed and analysed using qualitative data analysis software. Four theories were often simultaneously addressed: participatory research, emancipatory research, inclusive research and Arnstein's ladder. Barriers and facilitators could be divided into preparing, undertaking and finalising phases of research. Authors indicated that their motivation to conduct inclusive health research was based on demands by policy and funding bodies or was based on ethical considerations (i.e., ethical notions and giving people with ID a voice). Upon completion, authors perceived increased quality and validity of their research and several benefits for stakeholders (i.e., people with ID, researchers and healthcare professionals). Overall, there was consistency in their perception of the most important aspects of inclusive health research. Based on the analysis of included papers, four recommendations of inclusive health research with people with ID were found. Inclusive health research should be: (1) tailoring to the specific study; (2) anticipating all stakeholders; (3) considering its added value; and (4) providing insight into its process.

  7. Some current challenges in research on air pollution and health.

    Science.gov (United States)

    Samet, Jonathan M

    2014-01-01

    This commentary addresses some of the diverse questions of current interest with regard to the health effects of air pollution, including exposure-response relationships, toxicity of inhaled particles and risks to health, multipollutant mixtures, traffic-related pollution, accountability research, and issues with susceptibility and vulnerability. It considers the challenges posed to researchers as they attempt to provide useful evidence for policy-makers relevant to these issues. This commentary accompanies papers giving the results from the ESCALA project, a multi-city study in Latin America that has an overall goal of providing policy-relevant results. While progress has been made in improving air quality, driven by epidemiological evidence that air pollution is adversely affecting public health, the research questions have become more subtle and challenging as levels of air pollution dropped. More research is still needed, but also novel methods and approaches to address these new questions.

  8. Results of a transparent expert consultation on patient and public involvement in palliative care research

    Science.gov (United States)

    Daveson, Barbara A; de Wolf-Linder, Susanne; Witt, Jana; Newson, Kirstie; Morris, Carolyn; Higginson, Irene J; Evans, Catherine J

    2015-01-01

    Background: Support and evidence for patient, unpaid caregiver and public involvement in research (user involvement) are growing. Consensus on how best to involve users in palliative care research is lacking. Aim: To determine an optimal user-involvement model for palliative care research. Design: We hosted a consultation workshop using expert presentations, discussion and nominal group technique to generate recommendations and consensus on agreement of importance. A total of 35 users and 32 researchers were approached to attend the workshop, which included break-out groups and a ranking exercise. Descriptive statistical analysis to establish consensus and highlight divergence was applied. Qualitative analysis of discussions was completed to aid interpretation of findings. Setting/participants: Participants involved in palliative care research were invited to a global research institute, UK. Results: A total of 12 users and 5 researchers participated. Users wanted their involvement to be more visible, including during dissemination, with a greater emphasis on the difference their involvement makes. Researchers wanted to improve productivity, relevance and quality through involvement. Users and researchers agreed that an optimal model should consist of (a) early involvement to ensure meaningful involvement and impact and (b) diverse virtual and face-to-face involvement methods to ensure flexibility. Conclusion: For involvement in palliative care research to succeed, early and flexible involvement is required. Researchers should advertise opportunities for involvement and promote impact of involvement via dissemination plans. Users should prioritise adding value to research through enhancing productivity, quality and relevance. More research is needed not only to inform implementation and ensure effectiveness but also to investigate the cost-effectiveness of involvement in palliative care research. PMID:25931336

  9. A review on Bacopa monniera: Current research and future prospects

    Directory of Open Access Journals (Sweden)

    Gohil Kashmira

    2010-01-01

    Full Text Available In recent times, the use of herbal products has increased tremendously in the western world as well as in developed countries. Lately, one of the outstandingly important medicinal plants, widely used therapeutically in the orient and becoming increasingly popular in the west is Bacopa monniera, a well-known nootropic. The present review summarizes our current knowledge of pharmacological actions, preclinical and clinical studies, major bioactives, reported mechanisms of actions, clinical efficacy, safety and the possibility of interactions of the herb with the conventional drugs. Simultaneously, research updates as well as avenues for further research are also mentioned concerning the plant.

  10. Current status, research progress and future plan of Kartini research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Sardjono, Y.; Syarip; Tjiptono, T.W. [Yogyakarta Nuclear Research Center, Batan (Indonesia)

    1999-10-01

    The current status, research progress and future plan of the Kartini Research Reactor (KRR) is presented. The measurements of axial burn-up distributions for each fuel element by gamma scanning techniques, core axial power distribution display, fuel management for safeguards purpose as well as some research progress activities i.e.; utilization of beamport for: neutron radiography, application neutron activation analysis and history record of KRR power operations is also presented. The KRR is 100 kW pool water reactor type which uses natural circulation and provided by: five beamports in which one of them already coupled with natural uranium subcritical assembly, two thermalizing columns in which one of them is prepared for developing Boron Neutron Capture Therapy (BNCT), two rabbit systems utilized for special analysis uranium ore by delayed neutron counting techniques, one center timbre and 40 irradiation rack (lazy susan) for neutron activation analysis. The KRR was constructed as a second research reactor in Indonesia with special purpose for training and education, high safety margin with involve in high negative temperature coefficient which achieved its first criticality on January 25, 1979. The maximum power level on first criticality is 50 kW and since August 1981 up to now is operating 100 kW. Base on the KRR design limit, it is planned to increase the power level up to 250 kW in the future plan. The preliminary activities such as Non Destructive Testing (NDT) for some reactor components especially water tank and thermal column should be done before decided to increase power level. (author)

  11. SYRUPS: COMPOSITION, TECHNOLOGY, CURRENT STATE OF RESEARCH (REVIEW

    Directory of Open Access Journals (Sweden)

    M. E. Kim

    2014-01-01

    Full Text Available The overview data for the syrups formulation, including syrups for children, with synthetic substances were represented: assortment, composition, technological approach. The advantages and disadvantages of this dosage form were described. Details considered flavoring agents and other auxiliaries (stabilizers, preservatives, thickeners comprising syrups were closely examined. The issues of current research state of syrups for children were described.

  12. Research involving adults lacking capacity to consent: the impact of research regulation on 'evidence biased' medicine.

    Science.gov (United States)

    Shepherd, Victoria

    2016-09-08

    Society is failing in its moral obligation to improve the standard of healthcare provided to vulnerable populations, such as people who lack decision making capacity, by a misguided paternalism that seeks to protect them by excluding them from medical research. Uncertainties surround the basis on which decisions about research participation is made under dual regulatory regimes, which adds further complexity. Vulnerable individuals' exclusion from research as a result of such regulation risks condemning such populations to poor quality care as a result of 'evidence biased' medicine. This paper explores the research regulation provisions for proxy decision making for those unable to provide informed consent for themselves, and the subsequent legal and practical difficulties for decision-makers. There are two separate regulatory regimes governing research involving adults who lack capacity to consent in England and Wales. The Mental Capacity Act 2005 governs how incapacitated adults can be involved in research, however clinical trials of medicinal products are separately regulated by the Medicines for Human Use (Clinical Trials) Regulations 2004. There are significant differences under these dual regimes in the provisions for those lacking capacity to participate in medical research. The level of risk permitted differs, with a greater requirement for justification for participation in a clinical trial than other types of research. Who acts as proxy decision maker, how much information is provided to the person lacking capacity, and whether they retain the power of veto also significantly differs. The development of two separate regulatory regimes has resulted in significant differences between the provisions for clinical trials and other forms of research, and from usual medical practice. The resulting uncertainty has reinforced the tendency of those approving and conducting research to exclude adults lacking capacity to avoid difficult decisions about seeking

  13. Research on scheme of applying ASON to current networks

    Science.gov (United States)

    Mao, Y. F.; Li, J. R.; Deng, L. J.

    2008-10-01

    Automatically Switched Optical Network (ASON) is currently a new and hot research subject in the world. It can provide high bandwidth, high assembly flexibility, high network security and reliability, but with a low management cost. It is presented to meet the requirements for high-throughput optical access with stringent Quality of Service (QoS). But as a brand new technology, ASON can not be supported by the traditional protocol software and network equipments. And the approach to build a new ASON network on the basis of completely abandoning the traditional optical network facilities is not desirable, because it costs too much and wastes a lot of network resources can also be used. So how to apply ASON to the current networks and realize the smooth transition between the existing network and ASON has been a serious problem to many network operators. In this research, the status in quo of ASON is introduced first and then the key problems should be considered when applying ASON to current networks are discussed. Based on this, the strategies should be complied with to overcome these key problems are listed. At last, the approach to apply ASON to the current optical networks is proposed and analyzed.

  14. Improving industrial designers work process by involving user research

    DEFF Research Database (Denmark)

    Dai, Zheng; Ómarsson, Ólafur

    2011-01-01

    With changing times, new technologies and more opinionated consumers, the modern industrial designer has found himself in need of fresher and more up to date approaches in his daily work. In a fast moving industry, the designer needs to keep a thinking process of dynamic and subjective attitude....... User research is part of user centered design (UCD). UCD has a reputation for subjective and reflective practice. In this paper there are two example cases. One is conducted by a classical industrial design process, and another is costing half of energy and time in user research. These examples...... will give the grounding for believing that the industrial designer needs to adopt user research methods to a level where he can still continue to work under the very nature of industrial design that has made it a successful practice for the last century. The combing of the approaches and attitude will help...

  15. Current status of oral health research in Africa: an overview.

    Science.gov (United States)

    Kanoute, Aïda; Faye, Daouda; Bourgeois, Denis

    2012-12-01

    Research in oral health contributes effectively to decisions and strategies aimed at improving the oral health of populations. Further contributions to enhance current knowledge of oral health in Africa are required. The principal objective of this study was to produce an analysis of oral health research published from different subregions of Africa and to estimate bilateral and multilateral international cooperation in oral health research during the period 2005-2010. The PubMed database was searched for published articles on topics related to oral health in Africa. A total of 935 oral health-related articles were retrieved during April and May 2011. Publications emanating from Nigeria and South Africa accounted for a striking 68% of all oral health-related material published from Africa during the study period. Researchers from 30 different countries had participated in collaboration on at least one published article. A total of 262 journals had published at least one item examining oral health in Africa, but only 29 journals had published more than seven articles. These 29 journals accounted for 66% of all published material and induced non-African reviews (26%) and African reviews (40%). This study shows strong variation among countries in the production of articles on oral health whereby rich countries produce greater quantities of published research and poorer nations more frequently develop research partnerships with other countries. © 2012 FDI World Dental Federation.

  16. Gender relations and health research: a review of current practices

    Directory of Open Access Journals (Sweden)

    Bottorff Joan L

    2011-12-01

    Full Text Available Abstract Introduction The importance of gender in understanding health practices and illness experiences is increasingly recognized, and key to this work is a better understanding of the application of gender relations. The influence of masculinities and femininities, and the interplay within and between them manifests within relations and interactions among couples, family members and peers to influence health behaviours and outcomes. Methods To explore how conceptualizations of gender relations have been integrated in health research a scoping review of the existing literature was conducted. The key terms gender relations, gender interactions, relations gender, partner communication, femininities and masculinities were used to search online databases. Results Through analysis of this literature we identified two main ways gender relations were integrated in health research: a as emergent findings; and b as a basis for research design. In the latter, gender relations are included in conceptual frameworks, guide data collection and are used to direct data analysis. Conclusions Current uses of gender relations are typically positioned within intimate heterosexual couples whereby single narratives (i.e., either men or women are used to explore the influence and/or impact of intimate partner gender relations on health and illness issues. Recommendations for advancing gender relations and health research are discussed. This research has the potential to reduce gender inequities in health.

  17. Current safety practices in nano-research laboratories in China.

    Science.gov (United States)

    Zhang, Can; Zhang, Jing; Wang, Guoyu

    2014-06-01

    China has become a key player in the global nanotechnology field, however, no surveys have specifically examined safety practices in the Chinese nano-laboratories in depth. This study reports results of a survey of 300 professionals who work in research laboratories that handle nanomaterials in China. We recruited participants at three major nano-research laboratories (which carry out research in diverse fields such as chemistry, material science, and biology) and the nano-chemistry session of the national meeting of the Chinese Chemical Society. Results show that almost all nano-research laboratories surveyed had general safety regulations, whereas less than one third of respondents reported having nanospecific safety rules. General safety measures were in place in most surveyed nano-research laboratories, while nanospecific protective measures existed or were implemented less frequently. Several factors reported from the scientific literature including nanotoxicology knowledge gaps, technical limitations on estimating nano-exposure, and the lack of nano-occupational safety legislation may contribute to the current state of affairs. With these factors in mind and embracing the precautionary principle, we suggest strengthening or providing nanosafety training (including raising risk awareness) and establishing nanosafety guidelines in China, to better protect personnel in the nano-workplace.

  18. Current frontiers and future directions of telecoupling research

    Science.gov (United States)

    Liu, J.

    2016-12-01

    The world has been increasingly interconnected over long distances though processes such as international trade, migration, telecommunication, and disease spread. However, previous studies often focused on socioeconomic or environmental issues of distant processes. While these studies have generated useful information for individual disciplines, integrating socioeconomic and environmental information is essential for holistic understanding of complex global challenges and unbiased decision making to address the challenges. To advance integrated research, the framework of telecoupling (socioeconomic and environmental interactions over distances) has been developed to explicitly address both socioeconomic and environmental issues simultaneously. Although the framework is relatively new, it has already been applied to tackle a variety of globally important issues, such as food security, water resources, energy sustainability, land use, international trade (e.g., food, forest products, energy, wildlife, industrial products), species invasion, investment, ecosystem services, conservation, information dissemination, and tourism. These applications have identified many important research gaps (e.g. spillover systems) and hidden linkages (e.g. feedbacks) among distant areas of the world with profound implications for sustainable development, ecosystem health, and human well-being. While working with telecoupling presents more challenges than focusing only on disciplinary issues, support from funding agencies has helped accelerate research on telecoupling and more efforts are being aimed at framework quantification and operationalization. The presenter will provide an overview of the current frontiers, discuss future research directions, and highlight emerging opportunities and challenges in telecoupling research and governance.

  19. Current research in child and adolescent bipolar disorder.

    Science.gov (United States)

    Demeter, Christine A; Townsend, Lisa D; Wilson, Michael; Findling, Robert L

    2008-01-01

    Although recently more research has considered children with bipolar disorder than in the past, much controversy still surrounds the validity of the diagnosis. Furthermore, questions remain as to whether or not childhood expressions of bipolarity are continuous with adult manifestations of the illness. In order to advance current knowledge of bipolar disorders in children, researchers have begun to conduct phenomenological, longitudinal, treatment, and neuroimaging studies in youths who exhibit symptoms of bipolar illness, as well as offspring of parents with bipolar disorders. Regardless of the differences between research groups regarding how bipolar disorder in children is defined, it is agreed that pediatric bipolarity is a serious and pernicious illness. With early intervention during the period of time in which youths are exhibiting subsyndromal symptoms of pediatric bipolarity, it appears that the progression of the illness to the more malignant manifestation of the disorder may be avoided. This paper will review what is currently known and what still is left to learn about clinically salient topics that pertain to bipolar disorder in children and adolescents.

  20. Survey of biomass gasification. Volume III. Current technology and research

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-04-01

    This survey of biomass gasification was written to aid the Department of Energy and the Solar Energy Research Institute Biological and Chemical Conversion Branch in determining the areas of gasification that are ready for commercialization now and those areas in which further research and development will be most productive. Chapter 8 is a survey of gasifier types. Chapter 9 consists of a directory of current manufacturers of gasifiers and gasifier development programs. Chapter 10 is a sampling of current gasification R and D programs and their unique features. Chapter 11 compares air gasification for the conversion of existing gas/oil boiler systems to biomass feedstocks with the price of installing new biomass combustion equipment. Chapter 12 treats gas conditioning as a necessary adjunct to all but close-coupled gasifiers, in which the product is promptly burned. Chapter 13 evaluates, technically and economically, synthesis-gas processes for conversion to methanol, ammonia, gasoline, or methane. Chapter 14 compiles a number of comments that have been assembled from various members of the gasifier community as to possible roles of the government in accelerating the development of gasifier technology and commercialization. Chapter 15 includes recommendations for future gasification research and development.

  1. Current status of research and related activities in NAA application

    Energy Technology Data Exchange (ETDEWEB)

    Ab. Khalik bin Haji Wood [Malaysia Institute for Nuclear Technology Research, Bangi, Selangor (Malaysia)

    1999-10-01

    Current activities of Analytical Chemistry Group of MINT (Malaysia Institute for Nuclear Technology Research) laboratory for elemental analysis of trace amounts in environmental samples such as air particulate matter (on air filter), soils/sediments, water, flora/fauna, oil sludge/waste sludge, and tailing/blasting slag and others, utilizing particularly NAA (Neutron Activation Analysis) method are reviewed. The laboratory participates in the IAEA-organized Interlaboratory Comparison Studies to ensure the analytical system. Other activities include analytical chemistry services with ICP-mass spectrometry and GC/GCMS to compliment the NAA and, moreover, air and marine pollution studies with participation in the UNDP/RCA/IAEA project. (S. Ohno)

  2. Involving disabled children and young people as partners in research: a systematic review.

    Science.gov (United States)

    Bailey, S; Boddy, K; Briscoe, S; Morris, C

    2015-07-01

    Children and young people can be valuable partners in research, giving their unique perspectives on what and how research should be done. However, disabled children are less commonly involved in research than their non-disabled peers. This review investigated how disabled children have been involved as research partners; specifically how they have been recruited, the practicalities and challenges of involvement and how these have been overcome, and impacts of involvement for research, and disabled children and young people. The INVOLVE definition of involvement and the Equality and Human Rights Commission definition of disability were used. Relevant bibliographic databases were searched. Websites were searched for grey literature. Included studies had involved disabled children and young people aged 5-25 years in any study design. Reviews, guidelines, reports and other documents from the grey literature were eligible for inclusion. Twenty-two papers were included: seven reviews, eight original research papers, three reports, three guidelines and one webpage. Nine examples of involvement were identified. Recommendations included developing effective communication techniques, using flexible methods that can be adapted to needs and preferences, and ensuring that sufficient support and funding is available for researchers undertaking involvement. Positive impacts of involvement for disabled children included increased confidence, self-esteem and independence. Positive impacts for research were identified. Involving disabled children in research can present challenges; many of these can be overcome with sufficient time, planning and resources. More needs to be done to find ways to involve those with non-verbal communication. Generally, few details were reported about disabled children and young people's involvement in studies, and the quality of evidence was low. Although a range of positive impacts were identified, the majority of these were authors' opinions rather

  3. On Unsaturated Soil Mechanics - Personal Views on Current Research

    Science.gov (United States)

    Pande, G. N.; Pietruszczak, S.

    2015-09-01

    This paper presents the authors' personal views on current research being conducted by various research groups around the world in the broad area of mechanics of unsaturated geomaterials in general and soils in particular. The topic is of interest to a wide spectrum of scientists and engineers working in diverse areas such as geology and geophysics, powder technology, agricultural, petroleum, chemical, geotechnical, civil, environmental and nuclear engineering. Even if we restrict ourselves to civil, geotechnical and environmental engineering, it is noted that a plethora of hypotheses as well as a number of empirical and semi-empirical relations have been introduced for describing the mechanics of unsaturated porous media. However, many of these proposed advances as well as methods of testing may lack sound theoretical basis.

  4. Current Research and Management of Ovarian Cancer in China

    Institute of Scientific and Technical Information of China (English)

    GUMeijiao; SHIWei

    2002-01-01

    Ovarian cancer is ne of the most lethal malignant tumors in China,represents the third most common cancer after cervical cancer and endometrial cancer,and the first leading cause of death from hynaecological cancers.Due to the lack of effective screening strategies and the absence of symptoms in early-stage of disease,over 70% of patients present at an advanced stage.Despite the advances in surgical techniques and conventional chemotheraphy,the prognosis of ovarian cancer has not been improved significantly,and indeed the long-term survival for patients with advanced disease does not exceed 20%.The aetiology of ovarian cancer temains poorly understood.In China,the major focus of research is to clarify the mechanism underlying ovarian cancer,develop more effective life-saving diagnostic and therapeutic measures,and undertake more population-based studies.This article summarizes current research,diagnosis and management of ovarian cancer in China.

  5. Bulk Glassy Alloys: Historical Development and Current Research

    Directory of Open Access Journals (Sweden)

    Akihisa Inoue

    2015-06-01

    Full Text Available This paper reviews the development of current research in bulk glassy alloys by focusing on the trigger point for the synthesis of the first bulk glassy alloys by the conventional mold casting method. This review covers the background, discovery, characteristics, and applications of bulk glassy alloys, as well as recent topics regarding them. Applications of bulk glassy alloys have been expanding, particularly for Fe-based bulk glassy alloys, due to their unique properties, high glass-forming ability, and low cost. In the near future, the engineering importance of bulk glassy alloys is expected to increase steadily, and continuous interest in these novel metallic materials for basic science research is anticipated.

  6. On Unsaturated Soil Mechanics – Personal Views on Current Research

    Directory of Open Access Journals (Sweden)

    Pande G.N.

    2015-09-01

    Full Text Available This paper presents the authors’ personal views on current research being conducted by various research groups around the world in the broad area of mechanics of unsaturated geomaterials in general and soils in particular. The topic is of interest to a wide spectrum of scientists and engineers working in diverse areas such as geology and geophysics, powder technology, agricultural, petroleum, chemical, geotechnical, civil, environmental and nuclear engineering. Even if we restrict ourselves to civil, geotechnical and environmental engineering, it is noted that a plethora of hypotheses as well as a number of empirical and semi-empirical relations have been introduced for describing the mechanics of unsaturated porous media. However, many of these proposed advances as well as methods of testing may lack sound theoretical basis.

  7. Astrobites: Engaging Undergraduate Science Majors with Current Astrophysical Research

    Science.gov (United States)

    Zevin, Michael; Astrobites

    2017-01-01

    Astrobites is a graduate-student organization that publishes an online astrophysical literature blog (astrobites.com). The purpose of the site is to make current astrophysical research accessible to and exciting for undergraduate physical science majors and astronomy enthusiasts, and the site now hosts an archive of over 1300 posts summarizing recent astrophysical research. In addition, Astrobites presents posts on career guidance, practical 'how-to' articles, conference summaries, and astronomy news. Astrobites has an average of more than 1000 pageviews per day and reaches not only its target audience of undergraduates, but also graduate students and professionals within astronomy, astronomy enthusiasts, and educators. As we enter our seventh year of successful blogging, we share here the most up-to-date summary of our organization, readership, and growth.

  8. Aespoe hard rock laboratory. Current research projects 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    In 1986 SKB decided to construct the Aespoe Hard Rock Laboratory (HRL) in order to provide an opportunity for research, development and demonstration in a realistic and undisturbed underground rock environment down to the depth planned for the future deep repository. The focus of current and future work is on development and testing of site characterization methods, verification of models describing the function of the natural and engineered barriers and development, testing, and demonstration of repository technology. The program has been organised so that all important steps in the development of a repository are covered, in other words the Aespoe HRL constitutes a `dress rehearsal` for the Swedish deep geological repository for spent fuel and other long-lived waste. Geoscientific investigations on Aespoe and nearby islands began in 1986. Aespoe was selected as the site for the laboratory in 1988. Construction of the facility, which reaches a depth of 460 m below the surface, began in 1990 and was completed in 1995. A major milestone had been reached in 1996 with the completion of the pre-investigation and construction phases of the Aespoe HRL. The comprehensive research conducted has permitted valuable development and verification of site characterization methods applied from the ground surface, boreholes, and underground excavations. The results of this research are summarised in the book `Aespoe Hard Rock Laboratory - 10 years of Research` published by SKB in 1996. The Operating Phase of the Aespoe HRL began in 1995 and is expected to continue for 15-20 years, that is until the first stage of the development of the Swedish deep geological repository for spent nuclear fuel is expected to be completed. A number of research projects were initiated at the start of the Operating Phase. Most of these projects have made substantial progress since then and important results have been obtained. The purpose of this brochure is to provide a brief presentation of the

  9. Viewpoint on the current status of researches on sepsis

    Directory of Open Access Journals (Sweden)

    Zheng-guo WANG

    2012-11-01

    Full Text Available Sepsis is a common complication after severe trauma and burn, and also one of the main causes of death. Recently, although some new progresses were seen in antibiotic therapy, the mortality of sepsis is still on the rise, and the death rate as a result of sepsis is higher than a total of that of prostate cancer, breast cancer and AIDS. Therefore, sepsis has obviously become one of the serious ailments threatening human health. The present paper introduced the international definition of sepsis, severe sepsis and septic shock, the current researches on diagnosis and therapy, and proposed that we should not only pay attention to pathogenesis and treatment, but also to sepsis prevention in sepsis researches, and we should try to find out the breakthrough in the interaction and dynamic balance between human being and pathogenic factors. Researches on the strategies to revert strong toxicity of infectious agents to non-toxic or weak pathogenic factors, and to conduct further research concerning biological characteristics of microorganisms and mechanism of drug resistance in order to render them to lose the drug resistance ability, or to increase its sensitivity to the drugs. The above suggested approaches might form the future strategies for preventing and controlling sepsis.

  10. Support for international agricultural research: current status and future challenges.

    Science.gov (United States)

    Zeigler, Robert S; Mohanty, Samarendu

    2010-11-30

    The success of the first Green Revolution in the form of abundant food supplies and low prices over the past two decades has diverted the world's attention from agriculture to other pressing issues. This has resulted in lower support for the agricultural research work primarily undertaken by the 15 research centers of the Consultative Group on International Agricultural Research (CGIAR). The total support in real dollars for most of the last three decades has been more or less flat although the number of centers increased from 4 to 15. However, since 2000, the funding situation has improved for the CGIAR centers, with almost all the increase coming from grants earmarked for specific research projects. Even for some centers such as the International Rice Research Institute (IRRI), the downward trend continued as late as 2006 with the budget in real dollars reaching the 1978 level of support. The recent food crisis has renewed the call for a second Green Revolution by revitalizing yield growth to feed the world in the face of growing population and a shrinking land base for agricultural use. The slowdown in yield growth because of decades of neglect in agricultural research and infrastructure development has been identified as the underlying reason for the recent food crisis. For the second Green Revolution to be successful, the CGIAR centers will have to play a complex role by expanding productivity in a sustainable manner with fewer resources. Thus, it is crucial to examine the current structure of support for the CGIAR centers and identify the challenges ahead in terms of source and end use of funds for the success of the second Green Revolution. The objective of this paper is to provide a historical perspective on the support to the CGIAR centers and to examine the current status of funding, in particular, the role of project-specific grants in rebuilding capacity of these centers. The paper will also discuss the nature of the support (unrestricted vs. project

  11. Harvard Observing Project (HOP): Involving Undergraduates in Research Projects

    Science.gov (United States)

    Bieryla, Allyson

    2017-01-01

    The Harvard Observing Project (HOP) is designed to get students excited about observational astronomy while collecting data valuable to the scientific community. The primary goal is to give undergraduates a chance to try out observing with “no strings attached”. Observations are led by experienced observers, mostly graduate students. This not only gives graduate students extra opportunities to interact and teach undergraduates, but also a chance for them to get more observing experience. Each semester, we choose an interesting target and monitor it each week over the course of the semester using Harvard University’s 16-inch DFM Clay Telescope. These observing projects often produce large amounts of data. This provides an excellent dataset for a young undergraduate to analyze. Some successful semester-long observing projects have included variable stars, supernova and binary systems. Short-term projects have included exoplanet candidate followup, asteroid and comet followup and collaborating with the Pro-Am White Dwarf Monitoring (PAWM) project in attempts to detect a transiting Earth-sized planet orbiting a white dwarf. Each dataset is an opportunity for an undergraduate to be introduced to scientific research and present the results to the community.

  12. Livestock in biomedical research: history, current status and future prospective.

    Science.gov (United States)

    Polejaeva, Irina A; Rutigliano, Heloisa M; Wells, Kevin D

    2016-01-01

    Livestock models have contributed significantly to biomedical and surgical advances. Their contribution is particularly prominent in the areas of physiology and assisted reproductive technologies, including understanding developmental processes and disorders, from ancient to modern times. Over the past 25 years, biomedical research that traditionally embraced a diverse species approach shifted to a small number of model species (e.g. mice and rats). The initial reasons for focusing the main efforts on the mouse were the availability of murine embryonic stem cells (ESCs) and genome sequence data. This powerful combination allowed for precise manipulation of the mouse genome (knockouts, knockins, transcriptional switches etc.) leading to ground-breaking discoveries on gene functions and regulation, and their role in health and disease. Despite the enormous contribution to biomedical research, mouse models have some major limitations. Their substantial differences compared with humans in body and organ size, lifespan and inbreeding result in pronounced metabolic, physiological and behavioural differences. Comparative studies of strategically chosen domestic species can complement mouse research and yield more rigorous findings. Because genome sequence and gene manipulation tools are now available for farm animals (cattle, pigs, sheep and goats), a larger number of livestock genetically engineered (GE) models will be accessible for biomedical research. This paper discusses the use of cattle, goats, sheep and pigs in biomedical research, provides an overview of transgenic technology in farm animals and highlights some of the beneficial characteristics of large animal models of human disease compared with the mouse. In addition, status and origin of current regulation of GE biomedical models is also reviewed.

  13. Service User and Carer Involvement in Mental Health Education, Training and Research – A Literature Review

    OpenAIRE

    Minogue, Virginia; Holt, Barrie; Karban, Kate; Gelsthorpe, Simon; Firth, Sarah; Ramsay, Trevor

    2009-01-01

    As part of an evaluation of service users’ and carers’ experience of involvement in mental health education, training and research, an extended literature review was undertaken. The purpose of this was to review policy underpinning service user and carer involvement in those areas, identify the extent and range of involvement, the processes involved, and the extent to which the effectiveness and impact of involvement had been evaluated. The review found that there was a range of different way...

  14. Informed consent in human subject research: a comparison of current international and Nigerian guidelines.

    Science.gov (United States)

    Fadare, Joseph O; Porteri, Corinna

    2010-03-01

    Informed consent is a basic requirement for the conduct of ethical research involving human subjects. Currently, the Helsinki Declaration of the World Medical Association and the International Ethical Guidelines for Biomedical Research of the Council for International Organizations of Medical Sciences (CIOMS) are widely accepted as international codes regulating human subject research and the informed consent sections of these documents are quite important. Debates on the applicability of these guidelines in different socio-cultural settings are ongoing and many workers have advocated the need for national or regional guidelines. Nigeria, a developing country, has recently adopted its national guideline regulating human subject research: the National Health Research Ethics Committee (NHREC) code. A content analysis of the three guidelines was done to see if the Nigerian guidelines confer any additional protection for research subjects. The concept of a Community Advisory Committee in the Nigerian guideline is a novel one that emphasizes research as a community burden and should promote a form of "research friendship" to foster the welfare of research participants. There is also the need for a regular update of the NHREC code so as to address some issues that were not considered in its current version.

  15. Sexuality, HIV risk and potential acceptability of involving adolescent girls in microbicide research in Kisumu, Kenya.

    Science.gov (United States)

    Montandon, Michele; Sahin-Hodoglugil, Nuriye Nalan; Bukusi, Elizabeth; Agot, Kawango; Boland, Brigid; Cohen, Craig R

    2008-12-01

    Current microbicide clinical trials primarily enroll adult participants; however, females under the age of 18, because of their high rates of HIV acquisition, represent an important population for future microbicide clinical research. We sought to understand the individual, family and community-level factors that may influence the acceptability of microbicide use and research involving adolescent girls. We conducted 30 interviews with adolescent girls aged 14-17 and nine focus group discussions with adolescent girls, parents and community leaders in Kisumu, Kenya. Participants discussed adolescent sexuality, HIV prevention methods, perceptions about microbicide use and views about microbicide research involving adolescent girls. Adolescent sexual activity is stigmatised yet acknowledged to be a natural part of the 'adolescent stage.' Desperation to stop the spread of HIV among youth and support for female-initiated HIV prevention methods led to enthusiasm about microbicides and future microbicide research. Yet concerns about microbicides were numerous and included: difficulty using it in a timely manner due to the rushed, unplanned nature of adolescent sex; a fear of trying experimental products; concerns about microbicide efficacy; and parental worry that supporting microbicide use in youth would defy societal pressures that denounce adolescent sexual activity. Microbicide acceptability for youth in sub-Saharan Africa may be bolstered by desperation for new methods to stop the spread of HIV, yet hindered by misgivings about experimental HIV prevention methods for youth. Understanding and addressing the microbicide's perceived benefits and shortcomings, as well as the broader context of adolescent sexuality and HIV prevention, may facilitate future research and promotion of microbicides in this high-risk group.

  16. Communicating Research Through Student Involvement in Phenological Investigations

    Science.gov (United States)

    Sparrow, E. B.; Kopplin, M.; Gazal, R. M.; Robin, J. H.; Boger, R. A.

    2011-12-01

    Phenology plays a key role in the environment and ecosystem. Primary and secondary students around the world have been collecting vegetation phenology data and contributing to ongoing scientific investigations. They have increased research capacity by increasing spatial coverage of ground observations that can be useful for validation of remotely sensed data. The green-up and green-down phenology measurement protocols developed at the University of Alaska Fairbanks (UAF) as part of the Global Learning and Observations to Benefit the Environment (GLOBE) program, have been used in more than 250 schools in over 20 countries. In addition to contributing their data, students have conducted their own investigations and presented them at science fairs and symposiums, and international conferences. An elementary school student in Alaska conducted a comprehensive study on the green-down rates of native and introduced trees and shrubs. Her project earned her a one-year college scholarship at UAF. Students from the Model Secondary School for the Deaf in Washington, D. C. and from the Indiana School for the Deaf collaborated on a comparative green-up study, and were chosen to present at an international conference where students from more than 20 countries participated. Similarly, students in Thailand presented at national conferences, their studies such as "The Relationship between Environmental Conditions and Green-down of Teak Trees (Tectona grandis L.)" at Roong Aroon School, Bangkok and "The Comparison of Budburst and Green-up of Leab Trees (Ficus infectoria Roxb.) at Rob Wiang and Mae Khao Tom Sub-district in Chiang Rai Province". Some challenges in engaging students in phenological studies include the mismatch in timing of the start and end of the plant growing season with that of the school year in northern latitudes and the need for scientists and teachers to work with students to ensure accurate measurements. However these are outweighed by benefits to the scientists

  17. The current status of environmental health research in Australia.

    Science.gov (United States)

    Gowland, Angela; Cook, Angus; Heyworth, Jane

    2012-01-01

    At present, the extent of environmental health research in Australia is unclear and there are no recent overarching reviews of national publications on the subject. This study investigates the current status of environmental health research in Australia using a bibliometric analysis. Three databases (Medline, Web of Science, and AUSTHealth) were used to access original, peer-reviewed journal articles with Australian data published between 1 January 2001 and 11 June 2010. A total of 337 articles from 174 different journal titles were used in the analysis and were classified according to 15 pre-determined environmental health areas. The highest number of articles related to water health and resources (66 articles), exposure to hazardous chemicals (57 articles), and air pollution including indoor air (58 articles). These areas made up 54% of the total publication output over the past 10 years. The amount of environmental health research published in Australia over the past 10 years, and the topics explored in these studies, is comparable to that of other countries of similar socio-economic status.

  18. Precision viticulture in Brazil: Current research status on wine grape

    Directory of Open Access Journals (Sweden)

    Miele Alberto

    2014-01-01

    Full Text Available Technologies associated to precision viticulture (PV are not currently used by Brazilian growers. To overcome this situation, a research is being carried out since 2011 in a vineyard of Merlot using a wide range of PV technologies. During this period, several PV research activities were performed which will be concluded in a couple of years. Therefore, final results depend on further variable evaluation which should be done by means of geostatistic, Geographic Information Systems and Principal Component Analysis. This paper briefly presents a series of methodological procedures used in different ways to attain the objective of this research project. In the sequence, it describes one final result and nine partial ones. Morphological and physicochemical analyses of soil showed that the vineyards are established on three taxonomic classes of soil – Argissolo, Cambissolo and Neossolo −, which are formed by ten mapping units. The partial results are mainly related to the utilization of GIS, modeling and must and wine composition of five mapping units; however they show results of only one year. With the complete set of analyses, data should be spatialized and maps prepared. Then, it will be possible to recommend different practices to each soil type and to aid oenologists to direct wines to a specific quality pattern.

  19. Translational research in infectious disease: current paradigms and challenges ahead.

    Science.gov (United States)

    Fontana, Judith M; Alexander, Elizabeth; Salvatore, Mirella

    2012-06-01

    In recent years, the biomedical community has witnessed a rapid scientific and technologic evolution after the development and refinement of high-throughput methodologies. Concurrently and consequentially, the scientific perspective has changed from the reductionist approach of meticulously analyzing the fine details of a single component of biology to the "holistic" approach of broadmindedly examining the globally interacting elements of biological systems. The emergence of this new way of thinking has brought about a scientific revolution in which genomics, proteomics, metabolomics, and other "omics" have become the predominant tools by which large amounts of data are amassed, analyzed, and applied to complex questions of biology that were previously unsolvable. This enormous transformation of basic science research and the ensuing plethora of promising data, especially in the realm of human health and disease, have unfortunately not been followed by a parallel increase in the clinical application of this information. On the contrary, the number of new potential drugs in development has been decreasing steadily, suggesting the existence of roadblocks that prevent the translation of promising research into medically relevant therapeutic or diagnostic application. In this article, we will review, in a noninclusive fashion, several recent scientific advancements in the field of translational research, with a specific focus on how they relate to infectious disease. We will also present a current picture of the limitations and challenges that exist for translational research, as well as ways that have been proposed by the National Institutes of Health to improve the state of this field. Copyright © 2012 Mosby, Inc. All rights reserved.

  20. The Declaration of Helsinki in relation to medical research: historical and current perspectives.

    Science.gov (United States)

    Shrestha, B M

    2012-09-01

    Medical research aims at improving diagnostic, therapeutic and prophylactic measures and understanding of the aetiology and pathogenesis of diseases in humans, and their application to improve the quality of life and survival. The subjects involved are exposed to hazards inherent to the experiments. In order to protect the human subjects and to maintain high ethical standards, the World Medical Association had adopted the "Declaration of Helsinki" in 1964. The aim of this article is to provide a comprehensive review on the historical and current perspectives on the Declaration of Helsinki in relation to medical research on human subjects.

  1. Involving Children With Cancer in Health Promotive Research: A Case Study Describing Why, What, and How

    Science.gov (United States)

    Lindberg, Susanne; Wärnestål, Pontus; Svedberg, Petra

    2017-01-01

    Background Participatory research approaches have been introduced to meet end-users’ needs in the development of health promotion interventions among children. However, whereas children are increasingly involved as passive informants in particular parts of research, they are rarely involved as partners, equal to adult researchers, throughout the research process. This is especially prominent in the context of child health where the child is commonly considered to be vulnerable or when the research concerns sensitive situations. In these cases, researchers and gatekeepers to children’s involvement base their resistance to active involvement of children on potential adverse effects on the accuracy or quality of the research or on ethical or moral principles that participation might harm the child. Thus most research aimed at developing health promotion interventions for children in health care is primarily based on the involvement of parents, caregivers, and other stakeholders. Objective The objective of this paper is to discuss reasons for involving children in health promotive research and to explore models for children’s participation in research as a basis for describing how researchers can use design methodology and participatory approaches to support the participation and contribution of children in a vulnerable context. Methods We developed and applied a model for children's participation in research to the development of a digital peer support service for children cancer survivors. This guided the selection of appropriate research and design methodologies (such as interviews, focus groups, design sessions, and usability evaluation) for involving the children cancer survivors (8-12 years) in the design of a digital peer support service. Results We present a model for what children’s participation in research means and describe how we practically implemented this model in a research project on children with cancer. This paper can inform researchers in

  2. Current status of silicon materials research for photovoltaic applications

    Energy Technology Data Exchange (ETDEWEB)

    Ciszek, T F

    1985-04-01

    The desire for high solar cell efficiencies has been a strong factor in determining the course of recent silicon crystal growth research efforts for photovoltaics. This review, therefore, focuses on single-crystal, dislocation-free ingot growth methods (Czochralski growth, float zoning, and cold crucible growth) and on sheet growth technologies, generally multicrystalline, that have achieved moderately high (>13.5%) laboratory-scale efficiencies. These include dendritic web growth, growth from capillary dies, edge-supported pulling, ribbon-against-drop growth, and a recent technique termed crucible-free horizontal growth. Silicon ribbon crystals provide a favorable geometry and require no wafering, but they contain defects that limit solar cell performance. Growth processes, their current status, and cell efficiencies are discussed. Silicon material process steps before and after crystal growth are described, and the advantages of silicon are presented.

  3. Current Debates in Corporate Social Responsibility: An Agenda for Research

    Directory of Open Access Journals (Sweden)

    David Crowther

    2007-06-01

    Full Text Available Corporate Social Responsibility (CSR has a particular prominence at this point in time, featuring heavily in the discourses of both academe and business. The understanding of what is meant by CSR continues to evolve as a consensus is reached. Nevertheless some important debates continue – or are commencing – which need to be resolved. It is the purpose of this paper to highlight these as some of the current debates within the CSR community – and hence form a significant part of an agenda for research in the area. Specifically we focus upon three key areas for the management of business, namely setting standards for reporting, identifying and implementing sustainable practice, and the management of risk.

  4. Current Research Status of KHNP for Site Risk

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Kyemin; Jeon, Ho-Jun; Bahng, Ki-In; Na, Jang-Hwan [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    In Korea, by the geographical characteristics, many Nuclear Power Plants (NPPs) have been constructed and operated at a single site. This is above average level or number of plants per site in the world. For this reason, the public concerns for the safety of nuclear facilities increased after Fukushima Daiichi accident. As a result, comprehensive risk assessment and management for the site which have multi-unit NPPs were strongly asked. Currently, to solve it, many researches and projects has carried out by various Korean companies, research centers, and regulatory authorities. In this paper, R and D plans of KHNP for multi-unit risk were summarized. Firstly, the needs of multi-unit PSA were reviewed. R and D activities and plans of KHNP were summarized in the last part. In this paper, we summarized the R and D plans of KHNP for assessing the multi-unit risk. Currently, multi-unit risk or multi-unit PSA are important and practical issues in both nuclear industry and national energy policy. After Fukushima accident, several countries stopped the construction and the operation of NPPs, other countries which is maintaining the NPPs are being strongly asked to assess the risk for multi-unit NPPs at the same site. Because of Korean geographical characteristics, the number of NPPs which are above average level or number of plants per site in the world is being constructed and operated at a single site. The population density nearby each site is considered to be higher than that of other countries.

  5. Ecosystem services – current challenges and opportunities for ecological research

    Directory of Open Access Journals (Sweden)

    Klaus eBirkhofer

    2015-01-01

    Full Text Available The concept of ecosystem services was originally developed to illustrate the benefits that natural ecosystems generate for society and to raise awareness for biodiversity and ecosystem conservation. In this article we identify major challenges and opportunities for ecologists involved in empirical or modeling ecosystem service research. The first challenge arises from the fact that the ecosystem service concept has not been generated in the context of managed systems. Ecologists need to identify the effect of anthropogenic interventions in order to propose practices to benefit service-providing organisms and associated services. The second challenge arises from the need to evaluate relationships between indicators of ecosystem services that are collected in ecological studies while accounting for uncertainties of ecological processes that underlie these services. We suggest basing the assessment of ecosystem services on the utilization of sets of indicators that cover aspects of service-providing units, ecosystem management and landscape modification. The third challenge arises from our limited understanding of the nature of relationships between services and a lack of a general statistical framework to address these links. To manage ecosystem service provisioning, ecologists need to establish whether services respond to a shared driver or if services are directly linked to each other. Finally, studies relating biodiversity to ecosystem services often focus on services at small spatial or short temporal scales, but research on the protection of services is often directed towards services providing benefits at large spatial scales. Ecological research needs to address a range of spatial and temporal scales to provide a multifaceted understanding of how nature promotes human well-being. Addressing these challenges in the future offers a unique opportunity for ecologists to act as promoters for the understanding about how to conserve benefits

  6. [Video game and internet addiction. The current state of research].

    Science.gov (United States)

    Rehbein, F; Mößle, T; Arnaud, N; Rumpf, H-J

    2013-05-01

    The use of interactive screen media is widespread and for some users leads to pathological symptoms that are phenomenologically similar to signs of addictive disorders. Addictive use of computer games and other Internet applications, such as social media can be distinguished. In the past standard criteria to classify this new disorder were lacking. In DSM-5, nine criteria are proposed for diagnosing Internet gaming disorder. The focus is currently on video games as most studies have been done in this field. Prevalence estimations are difficult to interpret due to the lack of standard diagnostic measures and result in a range of the frequency of Internet addiction between 1 % and 4.2 % in the general German population. Rates are higher in younger individuals. For computer game addiction prevalence rates between 0.9 % and 1.7  % can be found in adolescents. Despite substantial comorbidity among those affected current research points to addictive media use as a stand-alone disorder.

  7. Expert involvement in policy development: A systematic review of current practice

    NARCIS (Netherlands)

    Fischer, A.R.H.; Wentholt, M.T.A.; Rowe, E.J.; Frewer, L.J.

    2014-01-01

    In what ways are experts involved in policy development, and with what results? This paper attempts to answer these questions through a structured review of the academic literature, focusing on the identification of ‘methodologies’ of expert involvement, and on analying the subsequent policy impact

  8. Pharmacists’ views on involvement in pharmacy practice research: Strategies for facilitating participation.

    Directory of Open Access Journals (Sweden)

    Armour C

    2007-06-01

    Full Text Available In order for community pharmacy practice to continue to evolve, pharmacy practice research on potential new services is essential. This requires the active participation of community pharmacists. At present the level of involvement of community pharmacists in pharmacy practice research is minimal. Objectives: To ascertain the attitudes of a group of research-experienced community pharmacists towards participating in research; to investigate the barriers and facilitators to participation; to identify potential strategies to increase the involvement of community pharmacists in research. Methods: A focus group was conducted with a purposive sample of 11 research-experienced community pharmacists. A pharmacist academic moderated the focus group using a semi-structured interview guide. The participants were asked about their attitudes towards research, previous involvement in research, barriers to their involvement and strategies to overcome these barriers. The session was audio-taped and notes were taken by an observer. Thematic analysis of the notes and audio-tape transcripts was conducted.Results: Three themes emerged around pharmacists’ attitudes towards research: pharmacists’ perception of the purpose of research, pharmacists’ motivation for involvement in research, and pharmacists’ desired role in research. Barriers to research participation were grouped into four themes: pharmacists’ mindset, communication, infrastructure (time, money and staff, and skills/knowledge. Strategies to address each of these barriers were suggested.Conclusions: Participants recognised the importance of research towards advancing their profession and this was a motivating factor for involvement in research. They perceived their role in research primarily as data collection. A series of practical strategies to overcome the barriers to participation were offered that researchers may wish to consider when promoting research outcomes and designing research

  9. Black and minority ethnic group involvement in health and social care research: A systematic review.

    Science.gov (United States)

    Dawson, Shoba; Campbell, Stephen M; Giles, Sally J; Morris, Rebecca L; Cheraghi-Sohi, Sudeh

    2017-08-15

    Patient and public involvement (PPI) in research is growing internationally, but little is known about black and minority ethnic (BME) involvement and the factors influencing their involvement in health and social care research. To characterize and critique the empirical literature on BME-PPI involvement in health and social care research. Systematic searches of six electronic bibliographic databases were undertaken, utilizing both MeSH and free-text terms to identify international empirical literature published between 1990 and 2016. All study designs that report primary data that involved BME groups in health or social care research. Screening was conducted by two reviewers. Data extraction and quality appraisal were performed independently. Data extraction focused on the level(s) of PPI involvement and where PPI activity occurred in the research cycle. Studies were quality-assessed using the guidelines for measuring the quality and impact of user involvement in research. Data were analysed using a narrative approach. Forty-five studies were included with the majority undertaken in the USA focusing on African Americans and indigenous populations. Involvement most commonly occurred during the research design phase and least in data analysis and interpretation. This is the first systematic review investigating BME involvement in health and social care research internationally. While there is a widespread support for BME involvement, this is limited to particular phases of the research and particular ethnic subgroups. There is a need to understand factors that influence BME involvement in all parts of the research cycle. © 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.

  10. Collaborative Research in Childhood Cancer Survivorship: The Current Landscape.

    Science.gov (United States)

    Bhatia, Smita; Armenian, Saro H; Armstrong, Gregory T; van Dulmen-den Broeder, Eline; Hawkins, Michael M; Kremer, Leontien C M; Kuehni, Claudia E; Olsen, Jørgen H; Robison, Leslie L; Hudson, Melissa M

    2015-09-20

    Survivors of childhood cancer carry a substantial burden of morbidity and are at increased risk for premature death. Furthermore, clear associations exist between specific therapeutic exposures and the risk for a variety of long-term complications. The entire landscape of health issues encountered for decades after successful completion of treatment is currently being explored in various collaborative research settings. These settings include large population-based or multi-institutional cohorts and single-institution studies. The ascertainment of outcomes has depended on self-reporting, linkage to registries, or clinical assessments. Survivorship research in the cooperative group setting, such as the Children's Oncology Group, has leveraged the clinical trials infrastructure to explore the molecular underpinnings of treatment-related adverse events, and to understand specific complications in the setting of randomized risk-reduction strategies. This review highlights the salient findings from these large collaborative initiatives, emphasizing the need for life-long follow-up of survivors of childhood cancer, and describing the development of several guidelines and efforts toward harmonization. Finally, the review reinforces the need to identify populations at highest risk, facilitating the development of risk prediction models that would allow for targeted interventions across the entire trajectory of survivorship.

  11. FES in Europe and Beyond: Current Translational Research

    Science.gov (United States)

    Coste, Christine Azevedo; Mayr, Winfried; Bijak, Manfred; Musarò, Antonio; Carraro, Ugo

    2016-01-01

    Capacity of adult neural and muscle tissues to respond to external Electrical Stimulation (ES) is the biological basis for the development and implementation of mobility impairment physiotherapy protocols and of related assistive technologies, e.g, Functional Electrical Stimulation (FES). All body tissues, however, respond to electrical stimulation and, indeed, the most successful application of FES is electrical stimulation of the heart to revert or limit effects of arrhythmias (Pace-makers and Defibrillators). Here, we list and discuss results of FES current research activities, in particular those presented at 2016 Meetings: the PaduaMuscleDays, the Italian Institute of Myology Meeting, the 20th International Functional Electrical Stimulation Society (IFESS) conference held in Montpellier and the Vienna Workshop on FES. Several papers were recently e-published in the European Journal of Translational Myology as reports of meeting presentations. All the events and publications clearly show that FES research in Europe and beyond is alive and promisses translation of results into clinical management of a very large population of persons with deficiencies. PMID:28078074

  12. FES in Europe and beyond: Current Translational Research

    Directory of Open Access Journals (Sweden)

    Christine Azevedo Coste

    2016-12-01

    Full Text Available Capacity of adult neural and muscle tissues to respond to external Electrical Stimulation (ES is the biological basis for the development and implementation of mobility impairment physiotherapy protocols and of related assistive technologies, e.g, Functional Electrical Stimulation (FES. All body tissues, however, respond to electrical stimulation and, indeed, the most successful application of FES is electrical stimulation of the heart to revert or limit effects of arrhythmias (Pace-makers and Defibrillators. Here, we list and discuss results of FES current research activities, in particular those presented at 2016 Meetings: the PaduaMuscleDays, the Italian Institute of Myology Meeting, the 20th International Functional Electrical Stimulation Society (IFESS conference held in Montpellier and the Vienna Workshop on FES. Several papers were recently e-published in the European Journal of Translational Myology as reports of meeting presentations. All the events and publications clearly show that FES research in Europe and beyond is alive and promisses translation of results into clinical management of a very large population of persons with deficiencies.

  13. State of multicultural neuropsychological assessment in children: current research issues.

    Science.gov (United States)

    Byrd, Desiree; Arentoft, Alyssa; Scheiner, Diane; Westerveld, Michael; Baron, Ida Sue

    2008-09-01

    Scientific attention to cultural considerations in child neuropsychological assessment has not developed parallel to the focus these issues have received in adult and elderly neuropsychological assessment. There are limited data on the presence, magnitude, etiology, and implications of culture-related differences in cognitive test performance among children. This preliminary report reviews the available empirical literature on the current state of multicultural neuropsychological assessment in children. The review identified articles by searching PubMed and PsycINFO databases, and the tables of contents of Developmental Neuropsychology and Child Neuropsychology from 2003-2008. Of the 1,834 abstracts reviewed, ten papers met inclusion criteria for the review. Five studies were completed in America; four of these compared performance between ethnic groups while the fifth examined neighborhood level poverty indicators exclusively within African-American children. Of the five international studies, all established local normative data and/or were exploratory investigations of neuropsychological functions in specific cultural groups, including Taiwanese infants, South African youth, and bilingual British children. Taken together, the results yield important clinical and research data that begin to inform many of the complex and fascinating mechanisms by which ethnic identity and culture impact cognitive development and the neuropsychological assessment of children. A critique of the existing literature and directions for future research are provided.

  14. Human behavioral assessments in current research of Parkinson's disease.

    Science.gov (United States)

    Asakawa, Tetsuya; Fang, Huan; Sugiyama, Kenji; Nozaki, Takao; Kobayashi, Susumu; Hong, Zhen; Suzuki, Katsuaki; Mori, Norio; Yang, Yilin; Hua, Fei; Ding, Guanghong; Wen, Guoqiang; Namba, Hiroki; Xia, Ying

    2016-09-01

    Parkinson's disease (PD) is traditionally classified as a movement disorder because patients mainly complain about motor symptoms. Recently, non-motor symptoms of PD have been recognized by clinicians and scientists as early signs of PD, and they are detrimental factors in the quality of life in advanced PD patients. It is crucial to comprehensively understand the essence of behavioral assessments, from the simplest measurement of certain symptoms to complex neuropsychological tasks. We have recently reviewed behavioral assessments in PD research with animal models (Asakawa et al., 2016). As a companion volume, this article will systematically review the behavioral assessments of motor and non-motor PD symptoms of human patients in current research. The major aims of this article are: (1) promoting a comparative understanding of various behavioral assessments in terms of the principle and measuring indexes; (2) addressing the major strengths and weaknesses of these behavioral assessments for a better selection of tasks/tests in order to avoid biased conclusions due to inappropriate assessments; and (3) presenting new concepts regarding the development of wearable devices and mobile internet in future assessments. In conclusion we emphasize the importance of improving the assessments for non-motor symptoms because of their complex and unique mechanisms in human PD brains.

  15. E-Learning: A Means to Increase Learner Involvement in Research

    Science.gov (United States)

    de Beer, Marie; Mason, Roger B.

    2014-01-01

    This paper investigates a method for increasing the involvement of marketing fourth year learners in academic research, by encouraging greater participation in, and commitment to, their research project in the Applied Marketing IV subject. It is assumed that greater involvement will result in a greater pass rate. The main reasons for this lack of…

  16. 77 FR 54584 - Final Action Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH...

    Science.gov (United States)

    2012-09-05

    ... Final Action Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines... resistance into a microorganism must be reviewed by the Recombinant DNA Advisory Committee (RAC) and approved... the NIH Guidelines will be revised from NIH Guidelines for Research Involving Recombinant...

  17. Public health services and systems research: current state of finance research.

    Science.gov (United States)

    Ingram, Richard C; Bernet, Patrick M; Costich, Julia F

    2012-11-01

    There is a growing recognition that the US public health system should strive for efficiency-that it should determine the optimal ways to utilize limited resources to improve and protect public health. The field of public health finance research is a critical part of efforts to understand the most efficient ways to use resources. This article discusses the current state of public health finance research through a review of public health finance literature, chronicles important lessons learned from public health finance research to date, discusses the challenges faced by those seeking to conduct financial research on the public health system, and discusses the role of public health finance research in relation to the broader endeavor of Public Health Services and Systems Research.

  18. Improving performance in golf: current research and implications from a clinical perspective

    Directory of Open Access Journals (Sweden)

    Kerrie Evans

    2015-10-01

    Full Text Available ABSTRACTGolf, a global sport enjoyed by people of all ages and abilities, involves relatively long periods of low intensity exercise interspersed with short bursts of high intensity activity. To meet the physical demands of full swing shots and the mental and physical demands of putting and walking the course, it is frequently recommended that golfers undertake golf-specific exercise programs. Biomechanics, motor learning, and motor control research has increased the understanding of the physical requirements of the game, and using this knowledge, exercise programs aimed at improving golf performance have been developed. However, while it is generally accepted that an exercise program can improve a golfer's physical measurements and some golf performance variables, translating the findings from research into clinical practice to optimise an individual golfer's performance remains challenging. This paper discusses how biomechanical and motor control research has informed current practice and discusses how emerging sophisticated tools and research designs may better assist golfers improve their performance.

  19. Science and cycling: current knowledge and future directions for research.

    Science.gov (United States)

    Atkinson, Greg; Davison, Richard; Jeukendrup, Asker; Passfield, Louis

    2003-09-01

    of power output is both physiologically and biophysically optimal for longer ( > 4 km) time-trials held in conditions of unvarying wind and gradient. For shorter races (e.g. a 1 km time-trial), an 'all out' effort from the start is advised to 'save' time during the initial phase that contributes most to total race time and to optimize the contribution of kinetic energy to race velocity. From a biophysical standpoint, the optimum pacing strategy for road time-trials may involve increasing power in headwinds and uphill sections and decreasing power in tailwinds and when travelling downhill. More research, using models and direct power measurement, is needed to elucidate fully how much such a pacing strategy might save time in a real race and how much a variable power output can be tolerated by a rider. The cyclist's diet is a multifactorial issue in itself and many researchers have tried to examine aspects of cycling nutrition (e.g. timing, amount, composition) in isolation. Only recently have researchers attempted to analyse interrelationships between dietary factors (e.g. the link between pre-race and in-race dietary effects on performance). The thermal environment is a mediating factor in choice of diet, since there may be competing interests of replacing lost fluid and depleted glycogen during and after a race. Given the prevalence of stage racing in professional cycling, more research into the influence of nutrition on repeated bouts of exercise performance and training is required.

  20. Vitamin K metabolism: current knowledge and future research.

    Science.gov (United States)

    Card, David J; Gorska, Renata; Cutler, Jacky; Harrington, Dominic J

    2014-08-01

    Vitamin K is an essential fat-soluble micronutrient that is required for the post-translational γ-carboxylation of specific glutamic acid residues in hepatic and extra-hepatic proteins involved in blood coagulation and preventing cartilage and vasculature calcification. In humans, sources of vitamin K are derived from plants as phylloquinone and bacteria as the menaquinones. Menadione is a synthetic product used as a pharmaceutical but also represents an intermediate in the tissue-specific conversion of vitamin K to menaquinone-4, which preferentially resides in tissues such as brain. Research into vitamin K metabolism is essential for the understanding of vitamin K biology in health and disease. Progress in this area, driven by knowledge of vitamin K and the availability of markers of vitamin K status, has already proved beneficial in many areas of medicine and further opportunities present themselves. Areas of interest discussed in this review include prophylactic administration of vitamin K1 in term and preterm neonates, interactions between vitamins K and E, the industrial conversion of vitamin K to dihydro-vitamin K in foods, tissue-specific conversion of vitamin K to menaquinone-4, the biological activity of the five and seven carbon metabolites of vitamin K and circadian variations.

  1. Neonatal research in India: current status, challenges, and the way forward.

    Science.gov (United States)

    Gupta, Shuchita; Chaurasia, Suman; Sankar, M Jeeva; Deorari, Ashok K; Paul, Vinod K; Agarwal, Ramesh

    2014-11-01

    The present article systematically reviews the current status of neonatal research in India by examining the research articles published by Indian authors in the last 10 years. It also enlists the major challenges and proposes a few potential solutions to improve the status of neonatal research in the country. The systematic review of 574 eligible articles indicates that majority of the studies were observational in nature, facility-based, and primarily investigator-driven with no external funding, had small sample size, and were published in journals with low impact factor. Only a few select government and non-government academic institutions contributed to most studies. The major challenges include shortage of faculty, no provision for dedicated research time, inadequate knowledge/skills in research methods, lack of funding opportunities, limited access to literature, non-existence of research administrative cell, inappropriately low perks to research staff, and poor support for data management and statistical analysis. The recently revised guidelines on clinical trials involving drugs have further increased the researcher's dilemma. The potential solutions are to increase the faculty strength in medical colleges, allow dedicated research time to them, appoint dedicated research cadre with emoluments at par with clinical faculty, initiate formal training in research methods, create nationwide free portal for access to literature, facilitate development of good protocols through technical guidance at all stages, make the process of funding quick and transparent, and to promote collaborative trans-disciplinary research. Experts from different domains should come together and formulate evidence based research priorities. Regulatory mechanisms should be kept proportionate to plausible risks of research, and detailed ethical guidelines for research in children should be formulated. And last but not least, harnessing postgraduate thesis potential to answer simple and

  2. Current trends and future directions in flower development research.

    Science.gov (United States)

    Scutt, Charlie P; Vandenbussche, Michiel

    2014-11-01

    Flowers, the reproductive structures of the approximately 400 000 extant species of flowering plants, exist in a tremendous range of forms and sizes, mainly due to developmental differences involving the number, arrangement, size and form of the floral organs of which they consist. However, this tremendous diversity is underpinned by a surprisingly robust basic floral structure in which a central group of carpels forms on an axis of determinate growth, almost invariably surrounded by two successive zones containing stamens and perianth organs, respectively. Over the last 25 years, remarkable progress has been achieved in describing the molecular mechanisms that control almost all aspects of flower development, from the phase change that initiates flowering to the final production of fruits and seeds. However, this work has been performed almost exclusively in a small number of eudicot model species, chief among which is Arabidopsis thaliana. Studies of flower development must now be extended to a much wider phylogenetic range of flowering plants and, indeed, to their closest living relatives, the gymnosperms. Studies of further, more wide-ranging models should provide insights that, for various reasons, cannot be obtained by studying the major existing models alone. The use of further models should also help to explain how the first flowering plants evolved from an unknown, although presumably gymnosperm-like ancestor, and rapidly diversified to become the largest major plant group and to dominate the terrestrial flora. The benefits for society of a thorough understanding of flower development are self-evident, as human life depends to a large extent on flowering plants and on the fruits and seeds they produce. In this preface to the Special Issue, we introduce eleven articles on flower development, representing work in both established and further models, including gymnosperms. We also present some of our own views on current trends and future directions of the

  3. Nontyphoidal salmonella disease: Current status of vaccine research and development.

    Science.gov (United States)

    Tennant, Sharon M; MacLennan, Calman A; Simon, Raphael; Martin, Laura B; Khan, M Imran

    2016-06-01

    Among more than 2500 nontyphoidal Salmonella enterica (NTS) serovars, S. enterica serovar Typhimurium and S. enterica serovar Enteritidis account for approximately fifty percent of all human isolates of NTS reported globally. The global incidence of NTS gastroenteritis in 2010 was estimated to be 93 million cases, approximately 80 million of which were contracted via food-borne transmission. It is estimated that 155,000 deaths resulted from NTS in 2010. NTS also causes severe, extra-intestinal, invasive bacteremia, referred to as invasive nontyphoidal Salmonella (iNTS) disease. iNTS disease usually presents as a febrile illness, frequently without gastrointestinal symptoms, in both adults and children. Symptoms of iNTS are similar to malaria, often including fever (>90%) and splenomegaly (>40%). The underlying reasons for the high rates of iNTS disease in Africa are still being elucidated. Evidence from animal and human studies supports the feasibility of developing a safe and effective vaccine against iNTS. Both antibodies and complement can kill Salmonella species in vitro. Proof-of-principle studies in animal models have demonstrated efficacy for live attenuated and subunit vaccines that target the O-antigens, flagellin proteins, and other outer membrane proteins of serovars Typhimurium and Enteritidis. More recently, a novel delivery strategy for NTS vaccines has been developed: the Generalized Modules for Membrane Antigens (GMMA) technology which presents surface polysaccharides and outer membrane proteins in their native conformation. GMMA technology is self-adjuvanting, as it delivers multiple pathogen-associated molecular pattern molecules. GMMA may be particularly relevant for low- and middle-income countries as it has the potential for high immunologic potency at a low cost and involves a relatively simple production process without the need for complex conjugation. Several vaccines for the predominant NTS serovars Typhimurium and Enteritidis, are

  4. Current Research Therapeutic Strategies for Alzheimer's Disease Treatment

    Science.gov (United States)

    Folch, Jaume; Petrov, Dmitry; Ettcheto, Miren; Abad, Sonia; Sánchez-López, Elena; García, M. Luisa; Olloquequi, Jordi; Beas-Zarate, Carlos; Auladell, Carme; Camins, Antoni

    2016-01-01

    Alzheimer's disease (AD) currently presents one of the biggest healthcare issues in the developed countries. There is no effective treatment capable of slowing down disease progression. In recent years the main focus of research on novel pharmacotherapies was based on the amyloidogenic hypothesis of AD, which posits that the beta amyloid (Aβ) peptide is chiefly responsible for cognitive impairment and neuronal death. The goal of such treatments is (a) to reduce Aβ production through the inhibition of β and γ secretase enzymes and (b) to promote dissolution of existing cerebral Aβ plaques. However, this approach has proven to be only modestly effective. Recent studies suggest an alternative strategy centred on the inhibition of the downstream Aβ signalling, particularly at the synapse. Aβ oligomers may cause aberrant N-methyl-D-aspartate receptor (NMDAR) activation postsynaptically by forming complexes with the cell-surface prion protein (PrPC). PrPC is enriched at the neuronal postsynaptic density, where it interacts with Fyn tyrosine kinase. Fyn activation occurs when Aβ is bound to PrPC-Fyn complex. Fyn causes tyrosine phosphorylation of the NR2B subunit of metabotropic glutamate receptor 5 (mGluR5). Fyn kinase blockers masitinib and saracatinib have proven to be efficacious in treating AD symptoms in experimental mouse models of the disease. PMID:26881137

  5. Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment

    Directory of Open Access Journals (Sweden)

    Jaume Folch

    2016-01-01

    Full Text Available Alzheimer’s disease (AD currently presents one of the biggest healthcare issues in the developed countries. There is no effective treatment capable of slowing down disease progression. In recent years the main focus of research on novel pharmacotherapies was based on the amyloidogenic hypothesis of AD, which posits that the beta amyloid (Aβ peptide is chiefly responsible for cognitive impairment and neuronal death. The goal of such treatments is (a to reduce Aβ production through the inhibition of β and γ secretase enzymes and (b to promote dissolution of existing cerebral Aβ plaques. However, this approach has proven to be only modestly effective. Recent studies suggest an alternative strategy centred on the inhibition of the downstream Aβ signalling, particularly at the synapse. Aβ oligomers may cause aberrant N-methyl-D-aspartate receptor (NMDAR activation postsynaptically by forming complexes with the cell-surface prion protein (PrPC. PrPC is enriched at the neuronal postsynaptic density, where it interacts with Fyn tyrosine kinase. Fyn activation occurs when Aβ is bound to PrPC-Fyn complex. Fyn causes tyrosine phosphorylation of the NR2B subunit of metabotropic glutamate receptor 5 (mGluR5. Fyn kinase blockers masitinib and saracatinib have proven to be efficacious in treating AD symptoms in experimental mouse models of the disease.

  6. Current pathways for epidemiological research in amyotrophic lateral sclerosis

    Science.gov (United States)

    FACTOR-LITVAK, PAM; AL-CHALABI, AMMAR; ASCHERIO, ALBERTO; BRADLEY, WALTER; CHÍO, ADRIANO; GARRUTO, RALPH; HARDIMAN, ORLA; KAMEL, FREYA; KASARSKIS, EDWARD; MCKEE, ANN; NAKANO, IMAHARU; NELSON, LORENE M.; EISEN, ANDREW

    2017-01-01

    Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease. The current status of the epidemiology, challenges to its study, and novel study design options are discussed in this paper. We focus on recent results from large-scale population based prospective studies, case-control studies and population based registries, risk factors, and neuropathologic findings in chronic traumatic encephalomyelopathy. We identify areas of interest for future research, including time-trends in the incidence and prevalence of ALS; the meaning of lifetime risk; the phenotypic description of ALS; the definition of familial versus sporadic ALS, syndromic aspects of ALS; specific risk factors such as military service, life style factors such as smoking, the use of statins, and the presence of β-N-methylamino-L-alanine (BMAA), an excitotoxic amino acid derivative possibly produced by cyanobacteria found in almost every terrestrial and aquatic habitat; the emergence and disappearance of an endemic ALS in areas of the Pacific; and gene-environment interactions in the etiology of ALS. To move the epidemiology forward, we suggest using well-characterized cohorts of newly diagnosed ALS patients to identify risk and prognostic factors; storing biological material for future studies; building on the National ALS Registry as a resource of future studies; working in multidisciplinary consortia; and addressing the possible early life etiology of ALS. PMID:23678878

  7. Sleep disturbance due to noise: Current issues and future research

    Directory of Open Access Journals (Sweden)

    Ken Hume

    2010-01-01

    Full Text Available There is growing interest in carrying out further research to understand and reduce the impact of aircraft noise on airport neighborhood in anticipation of the projected substantial increase in global aviation. Soundscapes provide new analytical methods and a broader, more comprehensive appreciation of the aural environment, which may have a useful role in understanding noise-induced sleep disturbance and annoyance. Current noise metrics like Leq do not provide a common language to report noise environment to residents, which is a key obstacle to effective noise management and acceptance. Non-auditory effects complicate the production of consistent dose-response functions for aircraft noise affecting sleep and annoyance. There are various end-points that can be chosen to assess the degree of sleep disturbance, which has detracted from the clarity of results that has been communicated to wider audiences. The World Health Organization (WHO-Europe has produced Night Noise Guidelines for Europe, which act as a clear guide for airports and planners to work towards. Methodological inadequacies and the need for simpler techniques to record sleep will be considered with the exciting potential to greatly increase cost-effective field data acquisition, which is needed for large scale epidemiological studies

  8. Rethinking cancer: current challenges and opportunities in cancer research.

    Science.gov (United States)

    Cagan, Ross; Meyer, Pablo

    2017-04-01

    Cancer therapeutics currently have the lowest clinical trial success rate of all major diseases. Partly as a result of the paucity of successful anti-cancer drugs, cancer will soon be the leading cause of mortality in developed countries. As a disease embedded in the fundamentals of our biology, cancer presents difficult challenges that would benefit from uniting experts from a broad cross-section of related and unrelated fields. Combining extant approaches with novel ones could help in tackling this challenging health problem, enabling the development of therapeutics to stop disease progression and prolong patient lives. This goal provided the inspiration for a recent workshop titled 'Rethinking Cancer', which brought together a group of cancer scientists who work in the academic and pharmaceutical sectors of Europe, America and Asia. In this Editorial, we discuss the main themes emerging from the workshop, with the aim of providing a snapshot of key challenges faced by the cancer research community today. We also outline potential strategies for addressing some of these challenges, from understanding the basic evolution of cancer and improving its early detection to streamlining the thorny process of moving promising drug targets into clinical trials. © 2017. Published by The Company of Biologists Ltd.

  9. Rethinking cancer: current challenges and opportunities in cancer research

    Directory of Open Access Journals (Sweden)

    Ross Cagan

    2017-04-01

    Full Text Available Cancer therapeutics currently have the lowest clinical trial success rate of all major diseases. Partly as a result of the paucity of successful anti-cancer drugs, cancer will soon be the leading cause of mortality in developed countries. As a disease embedded in the fundamentals of our biology, cancer presents difficult challenges that would benefit from uniting experts from a broad cross-section of related and unrelated fields. Combining extant approaches with novel ones could help in tackling this challenging health problem, enabling the development of therapeutics to stop disease progression and prolong patient lives. This goal provided the inspiration for a recent workshop titled ‘Rethinking Cancer’, which brought together a group of cancer scientists who work in the academic and pharmaceutical sectors of Europe, America and Asia. In this Editorial, we discuss the main themes emerging from the workshop, with the aim of providing a snapshot of key challenges faced by the cancer research community today. We also outline potential strategies for addressing some of these challenges, from understanding the basic evolution of cancer and improving its early detection to streamlining the thorny process of moving promising drug targets into clinical trials.

  10. Maltreatment, Academic Difficulty, and Systems-Involved Youth: Current Evidence and Opportunities

    Science.gov (United States)

    Stone, Susan; Zibulsky, Jamie

    2015-01-01

    Youth involved in child-serving systems of care (e.g., child welfare and juvenile justice) often exhibit specific academic performance problems. The magnitude of academic risk among these students is a serious concern given that school attachment, performance, and attainment closely relate to indicators of well-being across the lifespan. It is…

  11. Reference, or Advisory, Groups Involving Disabled People: Reflections from Three Contrasting Research Projects

    Science.gov (United States)

    Lewis, Ann; Parsons, Sarah; Robertson, Christopher; Feiler, Anthony; Tarleton, Beth; Watson, Debby; Byers, Richard; Davies, Jill; Fergusson, Ann; Marvin, Claire

    2008-01-01

    Increasingly in recent years, the involvement of disabled people as co-researchers has been regarded as "good practice." This has been informed by growing participatory and emancipatory research paradigms as well as user-focused policy imperatives. The benefits of these shifts apply to the research itself (improved definition, direction,…

  12. Can the impact of public involvement on research be evaluated? A mixed methods study

    Science.gov (United States)

    Barber, Rosemary; Boote, Jonathan D; Parry, Glenys D; Cooper, Cindy L; Yeeles, Philippa; Cook, Sarah

    2011-01-01

    Abstract Background  Public involvement is central to health and social research policies, yet few systematic evaluations of its impact have been carried out, raising questions about the feasibility of evaluating the impact of public involvement. Objective  To investigate whether it is feasible to evaluate the impact of public involvement on health and social research. Methods  Mixed methods including a two‐round Delphi study with pre‐specified 80% consensus criterion, with follow‐up interviews. UK and international panellists came from different settings, including universities, health and social care institutions and charitable organizations. They comprised researchers, members of the public, research managers, commissioners and policy makers, self‐selected as having knowledge and/or experience of public involvement in health and/or social research; 124 completed both rounds of the Delphi process. A purposive sample of 14 panellists was interviewed. Results  Consensus was reached that it is feasible to evaluate the impact of public involvement on 5 of 16 impact issues: identifying and prioritizing research topics, disseminating research findings and on key stakeholders. Qualitative analysis revealed the complexities of evaluating a process that is subjective and socially constructed. While many panellists believed that it is morally right to involve the public in research, they also considered that it is appropriate to evaluate the impact of public involvement. Conclusions  This study found consensus among panellists that it is feasible to evaluate the impact of public involvement on some research processes, outcomes and on key stakeholders. The value of public involvement and the importance of evaluating its impact were endorsed. PMID:21324054

  13. Central nervous system involvement in pediatric rheumatic diseases: current concepts in treatment.

    Science.gov (United States)

    Duzova, Ali; Bakkaloglu, Aysin

    2008-01-01

    Central nervous system (CNS) manifestations are not rare in pediatric rheumatic diseases. They may be a relatively common feature of the disease, as in systemic lupus erythematosus (SLE) and Behçet's disease. Direct CNS involvement of a systemic rheumatic disease, primary CNS vasculitis, indirect involvement secondary to hypertension, hypoxia and metabolic changes, and drug associated adverse events may all result in CNS involvement. We have reviewed the CNS manifestations of SLE, Behçet's disease, Henoch-Schönlein purpura, polyarteritis nodosa, juvenile idiopathic arthritis, juvenile ankylosing spondylitis, familial Mediterranean fever, scleroderma, sarcoidosis, Wegener's granulomatosis, Takayasu's arteritis, CINCA syndrome, Kawasaki disease, and primary CNS vasculitis; and adverse CNS effects of anti-rheumatic drugs in pediatric patients. The manifestations are diverse; ranging from headache, seizures, chorea, changes in personality, depression, memory and concentration problems, cognitive impairment, cerebrovascular accidents to coma, and death. The value of cerebrospinal fluid (CSF) examination (pleocytosis, high level of protein), auto-antibodies in serum and CSF, electroencephalography, neuroimaging with computerized tomography, magnetic resonance imaging, SPECT, PET, and angiography depends on the disease. Brain biopsy is gold standard for the diagnosis of CNS vasculitis, however it may be inconclusive in 25% of cases. A thorough knowledge of the rheumatic diseases and therapy-related adverse events is mandatory for the management of a patient with rheumatic disease and CNS involvement. Severe CNS involvement is associated with poor prognosis, and high mortality rate. High dose steroid and cyclophosphamide (oral or intravenous) are first choice drugs in the treatment; plasmapheresis, IVIG, thalidomide, and intratechal treatment may be valuable in treatment-resistant, and serious cases.

  14. 45 CFR 46.206 - Research involving, after delivery, the placenta, the dead fetus or fetal material.

    Science.gov (United States)

    2010-10-01

    ..., Human Fetuses and Neonates Involved in Research § 46.206 Research involving, after delivery, the placenta, the dead fetus or fetal material. (a) Research involving, after delivery, the placenta; the dead... 45 Public Welfare 1 2010-10-01 2010-10-01 false Research involving, after delivery, the...

  15. Aspirations and Assumptions: A Researcher's Account of Pupil Involvement in School-Based Research

    Science.gov (United States)

    Mearns, Tessa L.; Coyle, Do; de Graaff, Rick

    2014-01-01

    This paper describes a research project conducted in collaboration with 10 "pupil co-researchers" (PCRs) and their classes in a secondary school in the Netherlands. The main research tools employed were online and face-to-face group discussions, in which PCRs contributed as consultants, co-designers and assistants. The research proved a…

  16. Overview of recent and current research on the TCV tokamak

    Science.gov (United States)

    S. Codathe TCV Team

    2013-10-01

    Through a diverse research programme, the Tokamak à Configuration Variable (TCV) addresses physics issues and develops tools for ITER and for the longer term goals of nuclear fusion, relying especially on its extreme plasma shaping and electron cyclotron resonance heating (ECRH) launching flexibility and preparing for an ECRH and NBI power upgrade. Localized edge heating was unexpectedly found to decrease the period and relative energy loss of edge localized modes (ELMs). Successful ELM pacing has been demonstrated by following individual ELM detection with an ECRH power cut before turning the power back up to trigger the next ELM, the duration of the cut determining the ELM period. Negative triangularity was also seen to reduce the ELM energy release. H-mode studies have focused on the L-H threshold dependence on the main ion species and on the divertor leg length. Both L- and H-modes have been explored in the snowflake configuration with emphasis on edge measurements, revealing that the heat flux to the strike points on the secondary separatrix increases as the X-points approach each other, well before they coalesce. In L-mode, a systematic scan of the auxiliary power deposition profile, with no effect on confinement, has ruled it out as the cause of confinement degradation. An ECRH power absorption observer based on transmitted stray radiation was validated for eventual polarization control. A new profile control methodology was introduced, relying on real-time modelling to supplement diagnostic information; the RAPTOR current transport code in particular has been employed for joint control of the internal inductance and central temperature. An internal inductance controller using the ohmic transformer has also been demonstrated. Fundamental investigations of neoclassical tearing mode (NTM) seed island formation by sawtooth crashes and of NTM destabilization in the absence of a sawtooth trigger were carried out. Both stabilizing and destabilizing agents

  17. Consumer involvement in setting the health services research agenda: persistent questions of value.

    Science.gov (United States)

    Entwistle, Vikki; Calnan, Michael; Dieppe, Paul

    2008-10-01

    Interest in consumer involvement in health services research started to gain momentum at around the same time that the MRC Health Services Research Collaboration (HSRC) was established. Consumer involvement was not the focus of a formal research programme within the HSRC, but HSRC members took opportunities to conduct three projects relating to consumer involvement in research agenda-setting activities. These were: (1) a comparison of the focus of published research relating to the management of osteoarthritis of the knee with clinicians' and patients' ideas about research priorities; (2) a survey that examined the consumer involvement policies of public- and voluntary-sector organizations that fund health services research in the UK; and (3) a citizens' jury that was convened to develop priorities for research relating to primary health and social care in the Bristol area. This paper reviews the findings of these projects and highlights the continued need for attention to underlying values in the development and evaluation of future efforts to involve consumers in research agenda setting.

  18. “I Don't Think that Any Peer Review Committee . . . Would Ever ‘Get’ What I Currently Do”: How Institutional Metrics for Success and Merit Risk Perpetuating the (Reproduction of Colonial Relationships in Community-Based Participatory Research Involving Indigenous Peoples in Canada

    Directory of Open Access Journals (Sweden)

    Heather Castleden

    2015-09-01

    Full Text Available This article reports on findings from a study that explored how a group of leading health researchers who do Indigenous community-engaged research (n = 20 in Canada envision enacting ethically sound research with Indigenous communities, as well as the concomitant tensions associated with doing so. In particular, we explore how institutional metrics for assessing merit and granting tenure are seen to privilege conventional discourses of productivity and validity in research and, as a result, are largely incongruent with the relational values associated with decolonizing research through community-based participatory health research. Our findings reveal that colonial incursion from the academy risk filtering into such research agendas and create a conflict between relational accountability to community partners and academic accountability to one’s discipline and peers.

  19. CURRENT APPROACHES FOR RESEARCH OF MULTIPLE SCLEROSIS BIOMARKERS

    Directory of Open Access Journals (Sweden)

    Kolyada T.I

    2016-12-01

    Full Text Available Current data concerning features of multiple sclerosis (MS etiology, pathogenesis, clinical course and treatment of disease indicate the necessity of personalized approach to the management of MS patients. These features are the variety of possible etiological factors and mechanisms that trigger the development of MS, different courses of disease, and significant differences in treatment efficiency. Phenotypic and pathogenetic heterogeneity of MS requires, on the one hand, the stratification of patients into groups with different treatment depending on a number of criteria including genetic characteristics, disease course, stage of the pathological process, and forms of the disease. On the other hand, it requires the use of modern methods for assessment of individual risk of developing MS, its early diagnosis, evaluation and prognosis of the disease course and the treatment efficiency. This approach is based on the identification and determination of biomarkers of MS including the use of systems biology technology platforms such as genomics, proteomics, metabolomics and bioinformatics. Research and practical use of biomarkers of MS in clinical and laboratory practice requires the use of a wide range of modern medical and biological, mathematical and physicochemical methods. The group of "classical" methods used to study MS biomarkers includes physicochemical and immunological methods aimed at the selection and identification of single molecular biomarkers, as well as methods of molecular genetic analysis. This group of methods includes ELISA, western blotting, isoelectric focusing, immunohistochemical methods, flow cytometry, spectrophotometric and nephelometric methods. These techniques make it possible to carry out both qualitative and quantitative assay of molecular biomarkers. The group of "classical methods" can also include methods based on polymerase chain reaction (including multiplex and allele-specific PCR and genome sequencing

  20. Current status of NADPH oxidase research in cardiovascular pharmacology

    Directory of Open Access Journals (Sweden)

    Rodiño-Janeiro BK

    2013-07-01

    Full Text Available Bruno K Rodiño-Janeiro,1,2 Beatriz Paradela-Dobarro,1 María Isabel Castiñeiras-Landeira,1 Sergio Raposeiras-Roubín,1,3 José R González-Juanatey,1,3,4 Ezequiel Álvarez1,4 1Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain; 2European Molecular Biology Laboratory, Grenoble, France; 3Cardiology Department, University Clinic Hospital of Santiago de Compostela, Santiago de Compostela, Spain; 4Medicine Department, University of Santiago de Compostela, Santiago de Compostela, Spain Abstract: The implications of reactive oxygen species in cardiovascular disease have been known for some decades. Rationally, therapeutic antioxidant strategies combating oxidative stress have been developed, but the results of clinical trials have not been as good as expected. Therefore, to move forward in the design of new therapeutic strategies for cardiovascular disease based on prevention of production of reactive oxygen species, steps must be taken on two fronts, ie, comprehension of reduction-oxidation signaling pathways and the pathophysiologic roles of reactive oxygen species, and development of new, less toxic, and more selective nicotinamide adenine dinucleotide phosphate (NADPH oxidase inhibitors, to clarify both the role of each NADPH oxidase isoform and their utility in clinical practice. In this review, we analyze the value of NADPH oxidase as a therapeutic target for cardiovascular disease and the old and new pharmacologic agents or strategies to prevent NADPH oxidase activity. Some inhibitors and different direct or indirect approaches are available. Regarding direct NADPH oxidase inhibition, the specificity of NADPH oxidase is the focus of current investigations, whereas the chemical structure-activity relationship studies of known inhibitors have provided pharmacophore models with which to search for new molecules. From a general point of view, small-molecule inhibitors are preferred because of their hydrosolubility

  1. Summary of current research on Central Asian vortex

    Directory of Open Access Journals (Sweden)

    Lian-Mei YANG

    2017-03-01

    Full Text Available The Central Asian vortex (CAV is an important synoptic-scale system that causes rainstorms, short-term heavy precipitation, hail, and sustained low temperatures in Xinjiang. This paper summarizes the current research conducted on the CAV since the 1960s. The objective definition of the CAV has been revised and a deep and shallow CAV classification proposed. Two high-frequency areas of deep CAV activity are the Kazakhstan hills (Sayan mountains and the eastern area of the Aral Sea (Tashkent; events mostly occur in summer and 40% cause strong rainfall. In addition, two high-frequency activity areas of the shallow CAV are located in the west and south of the Pamirs Plateau and mostly occur in spring; 23.2% of occurrences cause strong rainfall. The western and eastern water vapor transport relates to westerlies and a strong low-level easterly jet stream (LLEJ extending from Gansu to Xinjiang, respectively, and water vapor over the Tibetan Plateau transports even more northwards and enters Xinjiang. The deep CAV has an obvious cold core structure down to 300 hPa. The conversion terms from eddy available potential energy (AE to eddy kinetic energy (KE and eddy kinetic energy inflow (BKE from the open atmospheric region boundaries are the main sources of KE which cause rapid development of the CAV. The anomalous anti-cyclone center over the northeast Atlantic is the fountain of Rossby wave energy dispersion; Rossby waves propagate from the northeast Atlantic to eastern Europe (Urals (EEU, and then continuously propagate to Central Asia causing development of the CAV. The CAV requires further study to characterize the meso-scale system structure and evolution characteristics. In addition, physical modeling of the severe convective weather occurring under the CAV is required to determine the critical impacts of this severe convective weather and enable forecasting and early-warning indexes.

  2. Do Public Involvement Activities in Biomedical Research and Innovation Recruit Representatively? A Systematic Qualitative Review.

    Science.gov (United States)

    Lander, Jonas; Hainz, Tobias; Hirschberg, Irene; Bossert, Sabine; Strech, Daniel

    2016-01-01

    Public involvement activities (PIAs) may contribute to the governance of ethically challenging biomedical research and innovation by informing, consulting with and engaging the public in developments and decision-making processes. For PIAs to capture a population's preferences (e.g. on issues in whole genome sequencing, biobanks or genome editing), a central methodological requirement is to involve a sufficiently representative subgroup of the general public. While the existing literature focusses on theoretical and normative aspects of 'representation', this study assesses empirically how such considerations are implemented in practice. It evaluates how PIA reports describe representation objectives, the recruitment process and levels of representation achieved. PIA reports were included from a systematic literature search if they directly reported a PIA conducted in a relevant discipline such as genomics, biobanks, biotechnology or others. PIA reports were analyzed with thematic text analysis. The text analysis was guided by an assessment matrix based on PIA-specific guidelines and frameworks. We included 46 relevant reports, most focusing on issues in genomics. 27 reports (59%) explicitly described representation objectives, though mostly without adjusting eligibility criteria and recruiting methods to the specific objective. 11 reports (24%) explicitly reported to have achieved the intended representation; the rest either reported failure or were silent on this issue. Representation of study samples in PIAs in biomedical research and innovation is currently not reported systematically. Improved reporting on representation would not only improve the validity and value of PIAs, but could also contribute to PIA results being used more often in relevant policy and decision-making processes. © 2016 S. Karger AG, Basel.

  3. Involving lay and professional stakeholders in the development of a research intervention for the DEPICTED study.

    Science.gov (United States)

    Lowes, Lesley; Robling, Michael R; Bennert, Kristina; Crawley, Charlotte; Hambly, Helen; Hawthorne, Kamila; Gregory, John W

    2011-09-01

    AIM This paper focuses on stakeholders' active involvement at key stages of the research as members of a Stakeholder Action Group (SAG), particularly in the context of lay stakeholder involvement. Some challenges that can arise and wider issues (e.g. empowerment, the impact of user involvement) are identified and explored within the literature on service user involvement in health care research, reflecting on the implications for researchers. BACKGROUND In the DEPICTED study, lay and professional stakeholders were actively involved in developing a complex research intervention. Lay stakeholders comprised teenage and adult patients with diabetes, parents and patient organization representatives. Professional stakeholders were from a range of disciplines. METHODS Three 1-day research meetings were attended by 13-17 lay stakeholders and 10-11 professional stakeholders (plus researchers). The SAG was responsible for reviewing evidence, advising on developing ideas for the research intervention and guiding plans for evaluation of the intervention in a subsequent trial. Formal evaluations were completed by stakeholders following each SAG meeting. RESULTS  Throughout the first (developmental) stage of this two-stage study, lay and professional stakeholders participated or were actively involved in activities that provided data to inform the research intervention. Lay stakeholders identified the need for and contributed to the design of a patient-held tool, strongly influenced the detailed design and content of the research intervention and outcome questionnaire, thus making a major contribution to the trial design. CONCLUSION Stakeholders, including teenagers, can be actively involved in designing a research intervention and impact significantly on study outcomes.

  4. A clash of paradigms? Western and indigenous views on health research involving Aboriginal peoples.

    Science.gov (United States)

    Campbell, Theresa Diane

    2014-07-01

    To explore the issues of data management and data ownership with regard to health research conducted in aboriginal or indigenous populations in Canada. Research with aboriginal communities in Canada has often been conducted by researchers who had little or no understanding of the community in which the research was taking place. This led to 'helicopter' research, which benefitted the researcher but not the community. National aboriginal leadership developed the ownership, control, access, and possession (OCAP) principles, which outline how to manage research data regarding aboriginal people and to counteract disrespectful methodologies. However, these principles present their own set of challenges to those who would conduct research with aboriginal populations. Documents from the Assembly of First Nations, the Government of Canada, Aboriginal writers and researchers, and Nursing theorists and researchers. This is a methodology paper that reviews the issues of data ownership when conducting research with Aboriginal populations. The authors explore indigenous and Western views of knowledge development, outline and discuss the OCAP principles, and present the Canadian Institute of Health Research's guidelines for health research involving aboriginal people as a guide for those who want to carry out ethical and culturally competent research, do no harm and produce research that can benefit aboriginal peoples. There are special considerations associated with conducting research with Aboriginal populations. The Assembly of First Nations wants researchers to use the Ownership, Control, Access and Possession (OCAP) principles with First Nations data. These principles are restrictive and need to be discussed with stakeholders before research is undertaken. In Canada, it is imperative that researchers use the Canadian Institute of Health Research Guidelines for Health Research Involving Aboriginal People to ensure culturally sensitive and ethical conduct during the course of

  5. International Inventory of Current Mexico-Related Research. Volume 4.

    Science.gov (United States)

    Montoya, Ricardo Anzaldua, Ed.; And Others

    The fourth annual research inventory describes 728 Mexican-related research projects being conducted in 1984 or to begin in 1985 in 14 countries. Data come from questionnaires sent during 1984 to more than 1,800 individual researchers and 650 institutions around the world. Each project description provides names and addresses of principal and…

  6. Current developments in environmental psychology : topics and researchers

    NARCIS (Netherlands)

    van der Werff, Ellen; Perlaviciute, Goda; Muinos, Gabriel

    2016-01-01

    The aim of this special issue is to bring the work of early-career researchers in environmental psychology to the spotlight. These young researchers come from different countries and cultures, have their own theoretical approaches and employ different research methods to increase knowledge on the re

  7. Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities

    Science.gov (United States)

    Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities, a 2013 workshop sponsored by the Epidemiology and Genomics Research Program.

  8. Bibliometric Analysis of Current Web Survey Research in China

    Institute of Scientific and Technical Information of China (English)

    ZHANG Qian; SHAO Peiji; FANG Jiaming

    2008-01-01

    In recent years, with the advancement of information technology and its application in survey activities, web surveys have not only greatly developed, but have also encountered many problems in China. An analysis of domestic research is important for better understanding of web surveys, to guide further research and application. This paper gives a bibliometric analysis of 120 domestic articles on web surveys from 1998 to 2006, on publication growth, author and organization distribution, journal distribution, and research subjects. Research on web surveys in China should make progress comparable with research abroad in comparative studies, specific studies, and technical application studies.

  9. Research and design of a novel current mode charge pump

    Science.gov (United States)

    Xianrui, Li; Xinquan, Lai; Yushan, Li; Qiang, Ye

    2009-10-01

    To meet the demands for a number of LEDs, a novel charge pump circuit with current mode control is proposed. Regulation is achieved by operating the current mirrors and the output current of the operational transconductance amplifier. In the steady state, the input current from power voltage retains constant, so reducing the noise induced on the input voltage source and improving the output voltage ripple. The charge pump small-signal model is used to describe the device's dynamic behavior and stability. Analytical predictions were verified by Hspice simulation and testing. Load driving is up to 800 mA with a power voltage of 3.6 V, and the output voltage ripple is less than 45 mV. The output response time is less than 8 μs, and the load current jumps from 400 to 800 mA.

  10. Research and design of a novel current mode charge pump

    Energy Technology Data Exchange (ETDEWEB)

    Li Xianrui; Lai Xinquan; Li Yushan; Ye Qiang, E-mail: lixianrui4213@126.co [Research Institute of Design Circuit, Xidian University, Xi' an 710071 (China)

    2009-10-15

    To meet the demands for a number of LEDs, a novel charge pump circuit with current mode control is proposed. Regulation is achieved by operating the current mirrors and the output current of the operational transconductance amplifier. In the steady state, the input current from power voltage retains constant, so reducing the noise induced on the input voltage source and improving the output voltage ripple. The charge pump small-signal model is used to describe the device's dynamic behavior and stability. Analytical predictions were verified by Hspice simulation and testing. Load driving is up to 800 mA with a power voltage of 3.6 V, and the output voltage ripple is less than 45 mV. The output response time is less than 8 {mu}s, and the load current jumps from 400 to 800 mA.

  11. Research and design of a novel current mode charge pump

    Institute of Scientific and Technical Information of China (English)

    Li Xianrui; Lai Xinquan; Li Yushan; Ye Qiang

    2009-01-01

    To meet the demands for a number of LEDs, a novel charge pump circuit with current mode control is proposed. Regulation is achieved by operating the current mirrors and the output current of the operational transcon ductance amplifier. In the steady state, the input current from power voltage retains constant, so reducing the noise induced on the input voltage source and improving the output voltage ripple. The charge pump small-signal model is used to describe the device's dynamic behavior and stability. Analytical predictions were verified by Hspice sim ulation and testing. Load driving is up to 800 mA with a power voltage of 3.6 V, and the output voltage ripple is less than 45 mV. The output response time is less than 8 μs, and the load current jumps from 400 to 800 mA.

  12. Current status of research on biophysical effects of ultrasound.

    Science.gov (United States)

    Barnett, S B; ter Haar, G R; Ziskin, M C; Nyborg, W L; Maeda, K; Bang, J

    1994-01-01

    This overview of bioeffects of ultrasound presents some key aspects of selected papers dealing with biophysical end-points. Its purpose is to establish a basis for exposure and dosimetric standards for medical ultrasonic equipment. It is intended to provide essential background resource material for the medical/scientific community, and more specifically for scientific working groups. This document was prepared by members of the Safety Committee of the World Federation for Ultrasound in Medicine and Biology. It was produced as a resource document in response to a request for information by Working Group 12 (Ultrasound exposure parameters) of the International Electrotechnical Commission Technical Committee 87, Ultrasonics. IEC TC 87, WG12 is the working group responsible for generating international standards for the classification of equipment by its acoustic fields based on safety thresholds. Our paper is intended to update and supplement information on the thermal mechanism provided in the publication, "WFUMB Symposium on Safety and Standardisation in Medical Ultrasound: Issues and Recommendations Regarding Thermal Mechanisms for Biological Effects of Ultrasound" (WFUMB 1992). It also provides an overview of trends in research into nonthermal mechanisms as a preliminary to the next WFUMB Symposium on Safety of Medical Ultrasound when this subject will be examined in detail by a select group of international experts. The WFUMB-sponsored workshop will take place in Utsunomiya, Japan during 11-15th July, 1994. The purpose of the meeting is to evaluate the scientific literature and to formulate internationally accepted recommendations on the safe use of diagnostic ultrasound that may be endorsed as official policy of the WFUMB. It should be noted that the current publication is not intended for review or endorsement as an official WFUMB document. It is produced as a scientific paper by individuals who are members of the WFUMB Safety Committee, and it therefore

  13. Leashes and Lies: Navigating the Colonial Tensions of Institutional Ethics of Research Involving Indigenous Peoples in Canada

    Directory of Open Access Journals (Sweden)

    Martha L. Stiegman

    2015-06-01

    Full Text Available Ethical standards of conduct in research undertaken at Canadian universities involving humans has been guided by the three federal research funding agencies through the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans (or TCPS for short since 1998. The statement was revised for the first time in 2010 and is now commonly referred to as the TCPS2, which includes an entire chapter (Chapter 9 devoted to the subject of research involving First Nations, Inuit, and Métis peoples of Canada. While the establishment of TCPS2 is an important initial step on the long road towards decolonizing Indigenous research within the academy, our frustrations—which echo those of many colleagues struggling to do research “in a good way” (see, for example, Ball & Janyst 2008; Bull, 2008; Guta et al., 2010 within this framework—highlight the urgent work that remains to be done if university-based researchers are to be enabled by establishment channels to do “ethical” research with Aboriginal peoples. In our (and others’ experience to date, we seem to have been able to do research in a good way, despite, not because of the TCPS2 (see Castleden et al., 2012. The disconnect between the stated goals of TCPS2, and the challenges researchers face when attempting to navigate how individual, rotating members of REBs interpret the TPCS2 and operate within this framework, begs the question: Wherein lies the disconnect? A number of scholars are currently researching this divide (see for example see Guta et al. 2010; Flicker & Worthington, 2011; and Guta et al., 2013. In this editorial, we offer an anecdote to illustrate our experience regarding some of these tensions and then offer reflections about what might need to change for the next iteration of the TCPS.

  14. The construct of food involvement in behavioral research: scale development and validation.

    Science.gov (United States)

    Bell, Rick; Marshall, David W

    2003-06-01

    The construct of involvement has been found to influence brand loyalty, product information search processing, responses to advertising communications, diffusion of innovations, and ultimately, product choice decisions. Traditionally, involvement has been defined as being a characteristic of either a product or of an individual. In the present research, we make an assumption that an individual's 'food involvement' is a somewhat stable characteristic and we hypothesized that involvement with foods would vary between individuals, that individuals who are more highly involved with food would be better able to discriminate between a set of food samples than would less food involved individuals, and that this discrimination would operate both in affective and perceptive relative judgments. Using standard scale construction techniques, we developed a measure of the characteristic of food involvement, based on activities relating to food acquisition, preparation, cooking, eating and disposal. After several iterations, a final 12-item measure was found to have good test-retest reliability and internal consistency within two subscales. A behavioral validation study demonstrated that measures of food involvement were associated with discrimination and hedonic ratings for a range of foods in a laboratory setting. These findings suggest that food involvement, as measured by the Food Involvement Scale, may be an important mediator to consider when undertaking research with food and food habits.

  15. Involving the public in mental health and learning disability research: Can we, should we, do we?

    Science.gov (United States)

    Paul, C; Holt, J

    2017-10-01

    WHAT IS KNOWN ON THE SUBJECT?: UK health policy is clear that researchers should involve the public throughout the research process. The public, including patients, carers and/or local citizens can bring a different and valuable perspective to the research process and improve the quality of research undertaken. Conducting health research is demanding with tight deadlines and scarce resources. This can make involving the public in research very challenging. WHAT THIS PAPER ADDS TO EXISTING KNOWLEDGE?: This is the first time the attitudes of researchers working in mental health and learning disability services towards PPI have been investigated. The principles of service user involvement in mental health and learning disability services may support PPI in research as a tool of collaboration and empowerment. This article extends our understanding of the cultural and attitudinal barriers to implementing PPI guidelines in mental health and learning disability services. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Researchers in mental health and learning disability services need to champion, share and publish effective involvement work. Structural barriers to PPI work should be addressed locally and successful strategies shared nationally and internationally. Where PPI guidelines are being developed, attention needs to be paid to cultural factors in the research community to win "hearts and minds" and support the effective integration of PPI across the whole research process. Introduction Patient and public involvement (PPI) is integral to UK health research guidance; however, implementation is inconsistent. There is little research into the attitudes of NHS health researchers towards PPI. Aim This study explored the attitude of researchers working in mental health and learning disability services in the UK towards PPI in health research. Method Using a qualitative methodology, semi-structured interviews were conducted with a purposive sample of eight researchers. A

  16. From Inflammation to Current and Alternative Therapies Involved in Wound Healing

    Science.gov (United States)

    Serra, Mariana Barreto; da Silva, Neemias Neves; Abreu, Iracelle Carvalho

    2017-01-01

    Wound healing is a complex event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. These phases are distinct in function and histological characteristics. However, they depend on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events. In this article, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency. Finally, we will discuss the current therapeutic interventions in the wounds treatment, and the alternative therapies used as promising results in the development of new products with healing potential. PMID:28811953

  17. From Inflammation to Current and Alternative Therapies Involved in Wound Healing

    Directory of Open Access Journals (Sweden)

    Mariana Barreto Serra

    2017-01-01

    Full Text Available Wound healing is a complex event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. These phases are distinct in function and histological characteristics. However, they depend on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events. In this article, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency. Finally, we will discuss the current therapeutic interventions in the wounds treatment, and the alternative therapies used as promising results in the development of new products with healing potential.

  18. The current status of nuclear research reactor in Thailand

    Energy Technology Data Exchange (ETDEWEB)

    Sittichai, C.; Kanyukt, R.; Pongpat, P. [Office of Atomic Energy for Peace, Bangkok (Thailand)

    1998-10-01

    Since 1962, the Thai Research Reactor has been serving for various kinds of activities i.e. the production of radioisotopes for medical uses and research and development on nuclear science and technology, for more than three decades. The existing reactor site should be abandoned and relocated to the new suitable site, according to Thai cabinet`s resolution on the 27 December 1989. The decommissioning project for the present reactor as well as the establishment of new nuclear research center were planned. This paper discussed the OAEP concept for the decommissioning programme and the general description of the new research reactor and some related information were also reported. (author)

  19. Undergraduate Research Involving Deaf and Hard-of-Hearing Students in Interdisciplinary Science Projects

    Directory of Open Access Journals (Sweden)

    Todd Pagano

    2015-05-01

    Full Text Available Scientific undergraduate research in higher education often yields positive outcomes for student and faculty member participants alike, with underrepresented students often showing even more substantial gains (academic, professional, and personal as a result of the experience. Significant success can be realized when involving deaf and hard-of-hearing (d/hh undergraduate students, who are also vastly underrepresented in the sciences, in interdisciplinary research projects. Even d/hh Associate degree level students and those in the first two years of their postsecondary careers can contribute to, and benefit from, the research process when faculty mentors properly plan/design projects. We discuss strategies, including the dissemination/communication of research results, for involving these students in research groups with different communication dynamics and share both findings of our research program and examples of successful chemical and biological research projects that have involved d/hh undergraduate students. We hope to stimulate a renewed interest in encouraging diversity and involving students with disabilities into higher education research experiences globally and across multiple scientific disciplines, thus strengthening the education and career pipeline of these students.

  20. Faculty Involvement in Inservice Education--Research and Service in a Teaching University.

    Science.gov (United States)

    Baden, Donald J.

    Faculty members in schools, colleges, and departments of education can and should be actively involved in research, teaching, and service. Research and service functions are as integral to the mission of the school of education as teaching, and should be scheduled with as much care and planning. In one school of education, a 5-year plan to…

  1. 78 FR 10538 - Protections for Subjects in Human Research Involving Pesticides

    Science.gov (United States)

    2013-02-14

    ... AGENCY 40 CFR Part 26 RIN 2070-AJ76 Protections for Subjects in Human Research Involving Pesticides... human subjects and to persons who submit the results of human research with pesticides to EPA. The amendments broaden the applicability of the rules to cover human testing with pesticides submitted to EPA...

  2. Psychometric Framework for Modeling Parental Involvement and Reading Literacy. IEA Research for Education

    Science.gov (United States)

    Punter, R. Annemiek; Glas, Cees A. W.; Meelissen, Martina R. M.

    2016-01-01

    Parental involvement is seen as one of the most malleable factors of the student's home situation, which makes it a relevant subject for schools, educational policies, and research. Though many studies have researched its role in student achievement, effects are not univocal. It is difficult to tell whether these inconsistent results are caused by…

  3. The power of symbolic capital in patient and public involvement in health research.

    Science.gov (United States)

    Locock, Louise; Boylan, Anne-Marie; Snow, Rosamund; Staniszewska, Sophie

    2017-10-01

    Policy-makers and health research funders increasingly require researchers to demonstrate that they have involved patients in the design and conduct of research. However, the extent to which patients and public have the power to get involved on an equal footing is dependent on their economic, cultural, social and symbolic capital. To explore power relations in patient and public involvement (PPI) in research, particularly how patients may wield symbolic capital to develop a more equal relationship. Narrative interviews with a maximum variation sample of 38 people involved as patients, carers or public in health research, analysed thematically. Symbolic capital may be demonstrated in a range of ways (sometimes alongside or in the absence of other forms of capital): illness experience, technical illness knowledge and the challenging outsider. Symbolic capital is unstable and dependent on others for recognition and legitimacy. Nonetheless, participants identify a gradual shift in power relations over time. Research into PPI has been conceptually and theoretically poor, limiting our understanding of its mechanisms and wider contextual elements. Our findings demonstrate the importance of reflecting on the forms of power and capital wielded by the health research community, and of acknowledging the way in which PPI is challenging the status quo. As one of the first papers to conceptualize how different forms of symbolic capital operate and their critical role in challenging the balance of power, our findings may help researchers better plan their PPI activities and reflect on their own power. © 2016 The Authors. Health Expectations Published by John Wiley & Sons Ltd.

  4. Critical Issues in Parental Involvement: A Collection of Research Summaries by Title VII Graduate Students.

    Science.gov (United States)

    Bermudez, Andrea B., Ed.; Rakow, Steven J., Ed.; Ensle, Anne Labay, Ed.

    This volume contains 18 summaries of research on parental involvement, carried out by inservice teachers completing a Master's degree in multicultural studies. All but one of the participants were certified Texas teachers working in bilingual and English-as-a-Second-Language (ESL) education. Their research critically examined many facets of the…

  5. Medical Big Data for Research Use: Current Status and Related Issues.

    Science.gov (United States)

    Ishikawa, Koichi Benjamin

    2016-09-01

    Advances in the computerization of information and development of technology have mitigated restrictions on handling of a large amount of information. This has resulted in growth of expectations for the use of large-scale databases, or so-called "big data." This is also the case in the field of healthcare. Projects that involve building of the national receipt database (NDB) of medical fee bill (receipt) information and special health check-up information based on the Act on Assurance of Medical Care for Elderly People and the development of medical information databases have been pursued by the national government, and considerable attention has also been focused on researches conducted through the secondary uses of publicly collected data. Aside from these trends, there are numerous projects which collect diagnosis procedure combination (DPC) data to build large-scale databases for research purposes. Following to the ethics guidelines for epidemiologic studies, they collect and analyze anonymized DPC data from cooperating institutions. This communication concentrates on the use of DPC data, and outlines the scale of data currently available for research use. Examples on the use of DPC data will be shown for analysis on the current status of clinical practice from the microscopic perspective and macroscopic analysis of community medical care provision. Additionally, potential for extending studies to long-term outcomes research, limitations and issues related to the use of medical big data will also be discussed.

  6. Collaboratives for Wildlife-Wind Turbine Interaction Research: Fostering Multistakeholder Involvement (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, K.

    2013-04-01

    This poster highlights the various wildlife-wind collaboratives (specific to wildlife-wind turbine interaction research) that currently exist. Examples of collaboratives are included along with contact information, objectives, benefits, and ways to advance the knowledge base.

  7. Aspirations and assumptions: a researcher's account of pupil involvement in school-based research

    NARCIS (Netherlands)

    Mearns, Tessa; Coyle, Do; de Graaff, Rick

    2014-01-01

    This paper describes a research project conducted in collaboration with 10 ‘pupil co-researchers’ (PCRs) and their classes in a secondary school in the Netherlands. The main research tools employed were online and face-to-face group discussions, in which PCRs contributed as consultants, co-designers

  8. Urban tourism research : Recent progress and current paradoxes

    NARCIS (Netherlands)

    Ashworth, Gregory; Page, Stephen J.

    Urban tourism has remained a consistent theme in the expansion of tourism research since the 1980s and several seminal papers (e.g. Ashworth, 1989, 2003) have reviewed the state of research and its progress towards a greater recognition. This Progress in Tourism Management review article moves our

  9. The Research on School Marketing: Current Issues and Future Directions

    Science.gov (United States)

    Oplatka, Izhar; Hemsley-Brown, Jane

    2004-01-01

    This review provides a synthesis of the scholarship that has sought to expand the understanding of educational marketing practice in schools. The following research questions guided this review. What are the common themes and characteristics that emerge from research about marketing in schools? What remains underdeveloped in the characterization…

  10. Postgraduate Research Supervision: A Critical Review of Current Practice

    Science.gov (United States)

    McCallin, Antoinette; Nayar, Shoba

    2012-01-01

    Changes in the funding and delivery of research programmes at the university level have, in recent years, resulted in significant changes to research supervision. This paper critically reviews key influences effecting postgraduate supervision. Analysis draws on literature spanning 2000-2010 to determine the appropriateness of traditional models of…

  11. Urban tourism research : Recent progress and current paradoxes

    NARCIS (Netherlands)

    Ashworth, Gregory; Page, Stephen J.

    2011-01-01

    Urban tourism has remained a consistent theme in the expansion of tourism research since the 1980s and several seminal papers (e.g. Ashworth, 1989, 2003) have reviewed the state of research and its progress towards a greater recognition. This Progress in Tourism Management review article moves our u

  12. The Article Idea Chart: A participatory action research tool to aid involvement in dissemination

    Directory of Open Access Journals (Sweden)

    Cheryl Forchuk

    2014-06-01

    Full Text Available Participatory-action research encourages the involvement of all key stakeholders in the research process and is especially well suited to mental health research. Previous literature outlines the importance of engaging stakeholders in the development of research questions and methodologies, but little has been written about ensuring the involvement of all stakeholders (especially non-academic members in dissemination opportunities such as publication development. The Article Idea Chart was developed as a specific methodology for engaging all stakeholders in data analysis and publication development. It has been successfully utilised in a number of studies and is an effective tool for ensuring the dissemination process of participatory-action research results is both inclusive and transparent to all team members, regardless of stakeholder group. Keywords: participatory-action research, mental health, dissemination, community capacity building, publications, authorship

  13. Human memory research: Current hypotheses and new perspectives

    Directory of Open Access Journals (Sweden)

    Antônio Jaeger

    Full Text Available Abstract Research on human memory has increased significantly in the last few decades. Inconsistencies and controversies inherent to such research, however, are rarely articulated on published reports. The goal of the present article is to present and discuss a series of open questions related to major topics on human memory research that can be addressed by future research. The topics covered here are visual working memory, recognition memory, emotion and memory interaction, and methodological issues of false memories studies. Overall, the present work reveals a series of open questions and alternative analysis which could be useful for the process of hypothesis generation, and consequently for the design and implementation of future research on human memory.

  14. Community perspectives on research consent involving vulnerable children in Western Kenya.

    Science.gov (United States)

    Vreeman, Rachel; Kamaara, Eunice; Kamanda, Allan; Ayuku, David; Nyandiko, Winstone; Atwoli, Lukoye; Ayaya, Samuel; Gisore, Peter; Scanlon, Michael; Braitstein, Paula

    2012-10-01

    Involving vulnerable pediatric populations in international research requires culturally appropriate ethical protections. We sought to use mabaraza, traditional East African community assemblies, to understand how a community in western Kenya viewed participation of children in health research and informed consent and assent processes. Results from 108 participants revealed generally positive attitudes towards involving vulnerable children in research, largely because they assumed children would directly benefit. Consent from parents or guardians was understood as necessary for participation while gaining child assent was not. They felt other caregivers, community leaders, and even community assemblies could participate in the consent process. Community members believed research involving orphans and street children could benefit these vulnerable populations, but would require special processes for consent.

  15. Incorporating current research into formal higher education settings using Astrobites

    Science.gov (United States)

    Sanders, Nathan E.; Kohler, Susanna; Faesi, Chris; Villar, Ashley; Zevin, Michael

    2017-10-01

    A primary goal of many undergraduate- and graduate-level courses in the physical sciences is to prepare students to engage in scientific research or to prepare students for careers that leverage skillsets similar to those used by research scientists. Even for students who may not intend to pursue a career with these characteristics, exposure to the context of applications in modern research can be a valuable tool for teaching and learning. However, a persistent barrier to student participation in research is familiarity with the technical language, format, and context that academic researchers use to communicate research methods and findings with each other: the literature of the field. Astrobites, an online web resource authored by graduate students, has published brief and accessible summaries of more than 1300 articles from the astrophysical literature since its founding in 2010. This article presents three methods for introducing students at all levels within the formal higher education setting to approaches and results from modern research. For each method, we provide a sample lesson plan that integrates content and principles from Astrobites, including step-by-step instructions for instructors, suggestions for adapting the lesson to different class levels across the undergraduate and graduate spectrum, sample student handouts, and a grading rubric.

  16. Review of current research on hydrocarbon production by plants

    Energy Technology Data Exchange (ETDEWEB)

    Benedict, H. M.; Inman, B.

    1979-01-01

    This review assesses the status of research and development in the area of plants that produce hydrocarbons as a possible replacement for traditional fossil fuels. The information is meant to be used as a basis for determining the scope of a possible R and D program by DOE/FFB. Except in the case of guayule (Parthenium argentatum Gray), research on hydrocarbon species generally has not advanced beyond preliminary screening, extraction, and growth studies. Virtually no field studies have been initiated; hydrocarbon component extraction, separation, identification, and characterization have been only timidly approached; the biochemistry of hydrocarbon formation remains virtually untouched; and potential market analysis has been based on insufficient data. Research interest is increasing in this area, however. Industrial interest understandably centers about guayule prospects and is supplemented by NSF and DOE research funds. Additional support for other research topics has been supplied by DOE and USDA and by certain university systems. Due to the infant state of technology in this area of energy research, it is not possible to predict or satisfactorily assess at this time the potential contribution that plant hydrocarbons might make toward decreasing the nation's dependence upon petroleum. However, the general impression received from experts interviewed during this review was that the major thrust of research should be directed toward the manufacture of petrochemical substitutes rather than fuel production.

  17. Review of current research on hydrocarbon production by plants

    Energy Technology Data Exchange (ETDEWEB)

    Benedict, H. M.; Inman, B.

    1979-01-01

    This review assesses the status of research and development in the area of plants that produce hydrocarbons as a possible replacement for traditional fossil fuels. The information is meant to be used as a basis for determining the scope of a possible R and D program by DOE/FFB. Except in the case of guayule (Parthenium argentatum Gray), research on hydrocarbon species generally has not advanced beyond preliminary screening, extraction, and growth studies. Virtually no field studies have been initiated; hydrocarbon component extraction, separation, identification, and characterization have been only timidly approached; the biochemistry of hydrocarbon formation remains virtually untouched; and potential market analysis has been based on insufficient data. Research interest is increasing in this area, however. Industrial interest understandably centers about guayule prospects and is supplemented by NSF and DOE research funds. Additional support for other research topics has been supplied by DOE and USDA and by certain university systems. Due to the infant state of technology in this area of energy research, it is not possible to predict or satisfactorily assess at this time the potential contribution that plant hydrocarbons might make toward decreasing the nation's dependence upon petroleum. However, the general impression received from experts interviewed during this review was that the major thrust of research should be directed toward the manufacture of petrochemical substitutes rather than fuel production.

  18. [Current situation and development trend of Chinese medicine information research].

    Science.gov (United States)

    Dong, Yan; Cui, Meng

    2013-04-01

    Literature resource service was the main service that Chinese medicine (CM) information offered. But in recent years users have started to request the health information knowledge service. The CM information researches and application service mainly included: (1) the need of strength studies on theory, application of technology, information retrieval, and information standard development; (2) Information studies need to support clinical decision making, new drug research; (3) Quick response based on the network monitoring and support to emergency countermeasures. CM information researches have the following treads: (1) developing the theory system structure of CM information; (2) studying the methodology system of CM information; (3) knowledge discovery and knowledge innovation.

  19. Current research trends in mountain biodiversity in NW Europe

    Directory of Open Access Journals (Sweden)

    Väisänen, Risto A.

    1998-12-01

    Full Text Available Focusing on four themes in relation to biodiversity (vegetation science, keystone grazers, long-term studies and protected areas, a synthesis of current research in the mountain areas of Fennoscandia, Iceland and Scotland is presented. Recent relevant advances in vegetation science include classifications of mountain habitats which together with species distribution maps offer new possibilities for analysis. Generalisations emerging from comparisons of the ecology and ecophysiology of plants between different mountain areas are greatly needed. Further studies on the ecological impacts of keystone grazers are urgently required because of the alarming rate of degradation of mountain habitats. The topics highlighted from northern Fennoscandia include (i the effect of overgrazing by reindeer on the cover of foliose lichens and on the regeneration of mountain birch, (ii the ecological interactions between the autumnal moth and mountain birch, and (Hi the effect of rodents on vegetation. Long-term studies of slow processes to capture rare but important events are needed to better understand the functioning of mountain ecosystems. Examples of such studies are presented for (i the moss Racomitrium lanuginosum as an indicator of airborne nitrogen pollution, (ii research based on cyclic oscillations of vole numbers, and (Hi the application of breeding birds in environmental assessment. The conservation of appropriate areas is important for mountain biodiversity. Mountain habitats have been protected extensively in northern Europe. The evaluation of how representative the existing areas are and how to use them for research need international co-ordination.

    [fr] On présente une synthèse de la recherche actuelle dans les régions de montagne de la Scandinavie, l'Islande et l'Ecosse, centrée sur quatre sujets autour de la biodiversité (science de la végétation, herbivores principaux, études à long terme et zones protégées. Les r

  20. Relationship Education Research: Current Status and Future Directions

    Science.gov (United States)

    Markman, Howard J.; Rhoades, Galena K.

    2011-01-01

    The overarching aim of this paper is to review research on relationship education programs and approaches that have been published or accepted for publication since the last review article in 2002. This paper provides a critical overview of the relationship education field and sets an agenda for research and practice for the next decade. A theme weaved throughout the paper are the ways in which relationship education is similar and different from couples therapy and we conclude that there can be a synergistic, healthy marriage between the two. We then provide recommendations for future directions for research in the relationship education field. Finally, the co-authors comment on our experiences in both the relationship education field and couples therapy field as both researchers and interventionists. PMID:22283386

  1. Research on cancer diagnosis in Malaysia: current status.

    Science.gov (United States)

    Looi, L M; Zubaidah, Z; Cheah, P L; Cheong, S K; Gudum, H R; Iekhsan, O; Ikram, S I; Jamal, R; Mak, J W; Othman, N H; Puteri, J N; Rosline, H; Sabariah, A R; Seow, H F; Sharifah, N A

    2004-06-01

    Cancer is a major morbidity and mortality concern in Malaysia. Based on National Cancer Registry data, the Malaysian population is estimated to bear a cancer burden of about 40,000 new cases per year, and a cumulative lifetime risk of about 1:4. Cancer research in Malaysia has to consider needs relevant to our population, and resources constraints. Hence, funding bodies prioritise cancers of high prevalence, unique to our community and posing specific clinical problems. Cancer diagnosis is crucial to cancer management. While cancer diagnosis research largely aims at improvements in diagnostic information towards more appropriate therapy, it also impacts upon policy development and other areas of cancer management. The scope of cancer diagnosis upon which this paper is based, and their possible impact on other R&D areas, has been broadly categorized into: (1) identification of aetiological agents and their linkages to the development of precancer and cancer (impact on policy development, cancer prevention and treatment), (2) cancer biology and pathogenesis (impact on cancer prevention, treatment strategies and product development), (3) improvements in accuracy, sensitivity and specificity in cancer detection, monitoring and classification (impact on technology development) and (4) prognostic and predictive parameters (impact on treatment strategies). This paper is based on data collected by the Working Group on Cancer Diagnosis Research for the First National Conference on Cancer Research Coordination in April 2004. Data was collated from the databases of Institutions/Universities where the authors are employed, the Ministry of Science, Technology and Innovation (MOSTI) and targeted survey feedback from key cancer researchers. Under the 7th Malaysia Plan, 76 cancer projects were funded through the Intensified Research in Priority Areas (IRPA) scheme of MOSTI, amounting to almost RM15 million of grant money. 47(61.8%) of these projects were substantially in cancer

  2. MicroRNA Detection: Current Technology and Research Strategies

    Science.gov (United States)

    Hunt, Eric A.; Broyles, David; Head, Trajen; Deo, Sapna K.

    2015-07-01

    The relatively new field of microRNA (miR) has experienced rapid growth in methodology associated with its detection and bioanalysis as well as with its role in -omics research, clinical diagnostics, and new therapeutic strategies. The breadth of this area of research and the seemingly exponential increase in number of publications on the subject can present scientists new to the field with a daunting amount of information to evaluate. This review aims to provide a collective overview of miR detection methods by relating conventional, established techniques [such as quantitative reverse transcription polymerase chain reaction (RT-qPCR), microarray, and Northern blotting (NB)] and relatively recent advancements [such as next-generation sequencing (NGS), highly sensitive biosensors, and computational prediction of microRNA/targets] to common miR research strategies. This should guide interested readers toward a more focused study of miR research and the surrounding technology.

  3. Neuroeconomics: cross-currents in research on decision-making

    NARCIS (Netherlands)

    Sanfey, A.G.; Loewenstein, G.; McClure, S.M.; Cohen, J.D.

    2006-01-01

    Despite substantial advances, the question of how we make decisions and judgments continues to pose important challenges for scientific research. Historically, different disciplines have approached this problem using different techniques and assumptions, with few unifying efforts made. However, the

  4. Symposium: Organizational Health Intervention Research: Current Empirical Developments

    DEFF Research Database (Denmark)

    Ipsen, Christine; Jenny, Gregor

    2014-01-01

    This symposium is one of three symposia submitted by the "International organizational health intervention research partnership". The aim of this symposium is to present new empirical developments based on participatory intervention models. All five studies have developed and applied intervention...

  5. Current research situation of titanium alloys in China

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Titanium and its alloys possess excellent comprehensive properties, and they are widely used in many fields. China pays great attentions to the research on new titanium alloys. This paper mainly reviews the research on new Ti alloys in China, for example, high strength and high toughness Ti alloys, burn resistant Tialloys, high temperature Ti alloys, low cost Ti alloys and so on.New basic theories on Ti alloys developed in China in recent years are also reviewed.

  6. Current research in transcultural psychiatry in the Nordic countries

    DEFF Research Database (Denmark)

    Ekblad, Solvig; Kastrup, Marianne Carisius

    2013-01-01

    This article discusses major themes in recent transcultural psychiatric research in the Nordic countries from 2008 to 2011: (a) epidemiological studies of migration, (b) indigenous populations, and (c) quality of psychiatric care for migrants. Over the past several decades, the populations......, and after migration, with potential effects on their physical, mental, social, and spiritual health. Growing interest in transcultural issues is reflected in the level of scientific research and clinical activity in the field by Nordic physicians, psychologists, social scientists, demographers, medical...

  7. Current status of quantitative rotational spectroscopy for atmospheric research

    Science.gov (United States)

    Drouin, Brian J.; Wlodarczak, Georges; Colmont, Jean-Marcel; Rohart, Francois

    2004-01-01

    Remote sensing of rotational transitions in the Earth's atmosphere has become an important method for the retrieval of geophysical temperatures, pressures and chemical composition profiles that requires accurate spectral information. This paper highlights the current status of rotational data that are useful for atmospheric measurements, with a discussion of the types the rotational lineshape measurements that are not generally available in either online repository.

  8. 2002–2012: 10 Years of Research Progress in Horizontal-Axis Marine Current Turbines

    Directory of Open Access Journals (Sweden)

    Kai-Wern Ng

    2013-03-01

    Full Text Available Research in marine current energy, including tidal and ocean currents, has undergone significant growth in the past decade. The horizontal-axis marine current turbine is one of the machines used to harness marine current energy, which appears to be the most technologically and economically viable one at this stage. A number of large-scale marine current turbines rated at more than 1 MW have been deployed around the World. Parallel to the development of industry, academic research on horizontal-axis marine current turbines has also shown positive growth. This paper reviews previous research on horizontal-axis marine current turbines and provides a concise overview for future researchers who might be interested in horizontal-axis marine current turbines. The review covers several main aspects, such as: energy assessment, turbine design, wakes, generators, novel modifications and environmental impact. Future trends for research on horizontal-axis marine current turbines are also discussed.

  9. Research Diagnostic criteria for Temporomandibular Disorders: current status & future relevance.

    Science.gov (United States)

    Dworkin, S F

    2010-10-01

    The Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), published in 1992, was based on international expert recommendations and available empirical data. The major rationale was to offer a putative diagnostic and classification system whose reliability, validity and clinical usefulness for TMD diagnosis and classification could be scientifically evaluated and then revised using an evidence-based model for successive iterations. The present journal issue attests to the accomplishment of that major objective: the RDC/TMD has been translated into 18 languages and used very extensively in international research. One important component of that research has been to yield reliable and valid data resulting in an evidence-based revision of the RDC/TMD now available for continuing research and clinical application. The present article offers recommendations and speculations regarding how the RDC/TMD may continue to serve the function of guiding future research and, most importantly, serve as an evidence-based diagnostic and classification system to aid in the rational choice of clinical care for TMD sufferers around the world.

  10. Do Research Intermediaries Reduce Perceived Coercion to Enter Research Trials Among Criminally Involved Substance Abusers?

    Science.gov (United States)

    Festinger, David S; Dugosh, Karen L; Croft, Jason R; Arabia, Patricia L; Marlowe, Douglas B

    2011-01-01

    We examined the efficacy of including a research intermediary (RI) during the consent process in reducing participants' perceptions of coercion to enroll in a research study. Eighty-four drug court clients being recruited into an ongoing study were randomized to receive a standard informed consent process alone (standard condition) or with an RI (intermediary condition). Before obtaining consent, RIs met with clients individually to discuss remaining concerns. Findings provided preliminary evidence that RIs reduced client perceptions that their participation might influence how clinical and judicial staff view them. This suggests that using RIs may improve participant autonomy in clinical studies.

  11. Material research for environmental sustainability in Thailand: current trends

    Science.gov (United States)

    Niranatlumpong, Panadda; Ramangul, Nudjarin; Dulyaprapan, Pongsak; Nivitchanyong, Siriluck; Udomkitdecha, Werasak

    2015-06-01

    This article covers recent developments of material research in Thailand with a focus on environmental sustainability. Data on Thailand’s consumption and economic growth are briefly discussed to present a relevant snapshot of its economy. A selection of research work is classified into three topics, namely, (a) resource utilization, (b) material engineering and manufacturing, and (c) life cycle efficiency. Material technologies have been developed and implemented to reduce the consumption of materials, energy, and other valuable resources, thus reducing the burden we place on our ecological system. At the same time, product life cycle study allows us to understand the extent of the environmental impact we impart to our planet.

  12. Current research on parenting styles, dimensions, and beliefs.

    Science.gov (United States)

    Smetana, Judith G

    2017-06-01

    For decades, parenting has been characterized in terms of broad global styles, with authoritative parenting seen as most beneficial for children's development. Concerns with greater sensitivity to cultural and contextual variations have led to greater specificity in defining parenting in terms of different parenting dimensions and greater consideration of the role of parenting beliefs in moderating links between parenting and adjustment. New research includes 'domain-specific' models that describe parents as flexibly deploying different practices depending on their goals, children's needs, and the types of behaviors towards which parenting is directed. These trends are described, and directions for future research are discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Material research for environmental sustainability in Thailand: current trends.

    Science.gov (United States)

    Niranatlumpong, Panadda; Ramangul, Nudjarin; Dulyaprapan, Pongsak; Nivitchanyong, Siriluck; Udomkitdecha, Werasak

    2015-06-01

    This article covers recent developments of material research in Thailand with a focus on environmental sustainability. Data on Thailand's consumption and economic growth are briefly discussed to present a relevant snapshot of its economy. A selection of research work is classified into three topics, namely, (a) resource utilization, (b) material engineering and manufacturing, and (c) life cycle efficiency. Material technologies have been developed and implemented to reduce the consumption of materials, energy, and other valuable resources, thus reducing the burden we place on our ecological system. At the same time, product life cycle study allows us to understand the extent of the environmental impact we impart to our planet.

  14. Current research activity in the measurement of thorium and the identification of future research needs.

    Science.gov (United States)

    White, M A; Howe, A M; Rosen, P; Holmes, L

    2001-01-01

    A pre-requisite in the setting and enforcement of regulatory limits for exposure to thorium in the workplace is that thorium and its progeny can be accurately measured. Literature surveys have shown that the majority of thorium measurements were performed using either a radiochemical technique, such as alpha or gamma spectroscopy, or ICP-MS. For many methods. there was a separation step to isolate and pre-concentrate thorium from the sample matrix. Thorium was most commonly measured in geological matrices and industrial materials. A survey of current research activity was performed through distribution of a questionnaire to laboratories and national centres. From the rcsponses, four areas of current activity were identified: (i) development of methods for low level thorium determination, (ii) biological monitoring and metabolism of thorium, (iii) environmental monitoring for thorium, and (iv) health risks from X ray contract media. Two key areas for priority research were identified by the thorium Thematic Network: namely sample preparation methods and for traceable standards and reference materials for thorium analysis.

  15. Research on Predicting Drive Current of Shipborne Satcom Antenna

    Directory of Open Access Journals (Sweden)

    Kong Jinping

    2015-01-01

    Full Text Available Predicting the effect of antenna wind load on servo system precisely is meaningful to ensure the safety of satcom antenna on operation, which can avoid overload operation. In this paper, the computational fluid dynamics is used to proceed numerical computation on the pressure distribution of the reflector and torque of drive shaft under different wind speed, windward angle and angle of pitch of the antenna. The simulation model is built under MATLAB/Simulink simulation environment, and the drive current of the antenna servo system is analyzed under wind load effect and ship swing. Then, a method of predicting drive current of antenna servo system according to the wind speed, wind direction and attitude of the antenna is concluded. And this method is verified by simulation at last.

  16. Research on current e-commerce of tourism in China

    OpenAIRE

    Lei, Jun

    2016-01-01

    The rapid development of e-commerce in China has been accompanied by a similar development in tourism-based e-commerce. Taking the network as the medium, e-commerce has already become the new model for tourism transactions in the information age: By building one convenient bridge between tourism-based enterprises and tourists, can directly influence the profitability of enterprises. The paper will introduce the current development of tourism-based e-commerce websites, by firstly examining...

  17. Current trends in safety testing and toxicological research

    Science.gov (United States)

    Zbinden, G.

    1982-06-01

    The paper reviews current concepts of toxicological evaluation of new drugs and other chemicals. Instead of completing a predetermined check-list toxicologists now consider the potential adverse effects of the substances under actual conditions of use. They then design experimental models which have a high probability to predict the toxic effects. Moreover, the enhanced susceptibilities of special risk populations is more and more taken into consideration.

  18. Transcranial Direct Current Stimulation: Considerations for Research in Adolescent Depression

    Directory of Open Access Journals (Sweden)

    Jonathan C. Lee

    2017-06-01

    Full Text Available Adolescent depression is a prevalent disorder with substantial morbidity and mortality. Current treatment interventions do not target relevant pathophysiology and are frequently ineffective, thereby leading to a substantial burden for individuals, families, and society. During adolescence, the prefrontal cortex undergoes extensive structural and functional changes. Recent work suggests that frontolimbic development in depressed adolescents is delayed or aberrant. The judicious application of non-invasive brain stimulation techniques to the prefrontal cortex may present a promising opportunity for durable interventions in adolescent depression. Transcranial direct current stimulation (tDCS applies a low-intensity, continuous current that alters cortical excitability. While this modality does not elicit action potentials, it is thought to manipulate neuronal activity and neuroplasticity. Specifically, tDCS may modulate N-methyl-d-aspartate receptors and L-type voltage-gated calcium channels and effect changes through long-term potentiation or long-term depression-like mechanisms. This mini-review considers the neurobiological rationale for developing tDCS protocols in adolescent depression, reviews existing work in adult mood disorders, surveys the existing tDCS literature in adolescent populations, reviews safety studies, and discusses distinct ethical considerations in work with adolescents.

  19. Research on Low Power Marine Current Power Generation System

    Directory of Open Access Journals (Sweden)

    Dongkai Peng

    2013-09-01

    Full Text Available This study proposes a simple topological structure and power control method for a small scale stand alone marine current system, in which a diode rectifier, DC/DC boost converter for the maximum power control, battery as a storage element and a single phase inverter to link with load. The study establishes the steady-state mathematical model of marine current power generation system and derives the formula between the maximum power point and dc battery voltage. Then use the measurements of DC voltage and DC current to obtain Maximum Power Point Tracking (MPPT by controlling the duty cycle of the boost converter switch in order to simplify the system structure and the control strategies. In this case, the hill climbing searching algorithm is employed to get maximum power point and the double closed loops control strategy is used to improve the dynamic and static performance of single phase inverter. The simulation model is developed in MATLAB/Simulink. And the control method is executed in dSPACE1104 real-time platform. The simulation and experimental results demonstrate the feasibility and validity of the proposed control strategies.

  20. Artificial Neural Networks in Policy Research: A Current Assessment.

    Science.gov (United States)

    Woelfel, Joseph

    1993-01-01

    Suggests that artificial neural networks (ANNs) exhibit properties that promise usefulness for policy researchers. Notes that ANNs have found extensive use in areas once reserved for multivariate statistical programs such as regression and multiple classification analysis and are developing an extensive community of advocates for processing text…

  1. Talent management : Current theories and future research directions

    NARCIS (Netherlands)

    Al Ariss, A.; Cascio, W.F.; Paauwe, J.

    2014-01-01

    Research on Talent Management (TM) has been lagging behind businesses in offering vision and leadership in this field. After sketching a comprehensive outline of knowledge about TM, theoretical as well as practical, we introduce the papers in this special issue and their important contributions.

  2. Applying Current Theory and Research in Career Exploration to Practice.

    Science.gov (United States)

    Blustein, David L.

    1992-01-01

    Provides selected review of two lines of recent research on career exploration (identifying antecedents of exploratory activity and application of information processes biases to career exploration), with specific focus on applications for counseling practice. Describes relevant counseling interventions and concludes with summary of six goals to…

  3. Current research in transcultural psychiatry in the Nordic countries.

    Science.gov (United States)

    Ekblad, Solvig; Kastrup, Marianne Carisius

    2013-12-01

    This article discusses major themes in recent transcultural psychiatric research in the Nordic countries from 2008 to 2011: (a) epidemiological studies of migration, (b) indigenous populations, and (c) quality of psychiatric care for migrants. Over the past several decades, the populations of the Nordic countries, Denmark, Finland, Norway, and Sweden, which were relatively homogeneous, have become increasingly culturally diverse. Many migrants to Nordic countries have been exposed to extreme stress, such as threats of death and/or torture and other severe social adversities before, during, and after migration, with potential effects on their physical, mental, social, and spiritual health. Growing interest in transcultural issues is reflected in the level of scientific research and clinical activity in the field by Nordic physicians, psychologists, social scientists, demographers, medical anthropologists, as well as other clinicians and policy planners. Research includes work with migrants and indigenous minorities in the Nordic countries, as well as comparisons with mental health in postconflict countries. We conclude by suggesting future directions for transcultural psychiatry research and providing guidelines for the education and training of future clinicians in the Nordic countries.

  4. Gifted Male Readers: Current Understandings and Suggestions for Future Research

    Science.gov (United States)

    Pagnani, Alexander R.

    2013-01-01

    Research literature concerning gifted male readers relies primarily on more extensive bodies of work regarding gifted males and male readers. Studied as a whole, the two halves portray a worrisome state of affairs for gifted male readers, who lag behind their female counterparts in the same patterns found across the ability spectrum. This literacy…

  5. Current Research and Opportunities to Address Environmental Asbestos Exposures

    Science.gov (United States)

    Asbestos-related diseases continue to result in approximately 120,000 deaths every year in the United States and worldwide.Although extensive research has been conducted on health effects of occupational exposures to asbestos, many issues related to environmental asbestos exposur...

  6. Behavioral Marital Therapy: Current Trends in Research, Assessment and Practice.

    Science.gov (United States)

    Jacobson, Neil S.

    1980-01-01

    Behavioral Marital Therapy (BMT) is clinically useful because it includes elaborating procedures, modifying the spouse's self-defeating cognitions, and moving toward early intervention and prevention. Each article in this issue of American Journal of Family Therapy focuses on innovations in BMT, either in research or practice. (Author/NRB)

  7. Dyslexia and the Brain: What Does Current Research Tell Us?

    Science.gov (United States)

    Hudson, Roxanne F.; High, Leslie; Al Otaiba, Stephanie

    2007-01-01

    Dyslexia is a disorder of the language-processing systems in the brain. It is a specific learning disability in reading that often affects spelling as well. This article describes: (1) Common characteristics experienced by people with dyslexia or reading disabilities; (2) Common misconceptions about dyslexia; (3) What brain research tell us about…

  8. Materials for hydrogen storage: current research trends and perspectives.

    Science.gov (United States)

    van den Berg, Annemieke W C; Areán, Carlos Otero

    2008-02-14

    Storage and transport of hydrogen constitutes a key enabling technology for the advent of a hydrogen-based energy transition. Main research trends on hydrogen storage materials, including metal hydrides, porous adsorbents and hydrogen clathrates, are reviewed with a focus on recent developments and an appraisal of the challenges ahead. .

  9. Artificial Neural Networks in Policy Research: A Current Assessment.

    Science.gov (United States)

    Woelfel, Joseph

    1993-01-01

    Suggests that artificial neural networks (ANNs) exhibit properties that promise usefulness for policy researchers. Notes that ANNs have found extensive use in areas once reserved for multivariate statistical programs such as regression and multiple classification analysis and are developing an extensive community of advocates for processing text…

  10. Business model innovation: Past research, current debates, and future directions

    DEFF Research Database (Denmark)

    Hossain, Mokter

    2017-01-01

    Purpose – The purpose of this paper is to provide state-of-the-art knowledge about business model innovation (BMI) and suggest avenues for future research. Design/methodology/approach – A systematic literature review approach was adopted with thematic analysis being conducted on 92 articles...

  11. Current research in Spain on walnut for wood production

    Science.gov (United States)

    Neus Alet& #224; Neus NO-VALUE

    2004-01-01

    The Department of Mediterranean Trees at the Institut de Recerca i Tecnologia Agroalimentaries (IRTA) in Spain initiated a research program in 1993 to examine the variability among walnut species for wood production and to establish orchards with improved selections. The main objective of the programme is to obtain superior Persian walnut (Juglans regia...

  12. Current Research and Opportunities to Address Environmental Asbestos Exposures

    Science.gov (United States)

    Asbestos-related diseases continue to result in approximately 120,000 deaths every year in the United States and worldwide.Although extensive research has been conducted on health effects of occupational exposures to asbestos, many issues related to environmental asbestos exposur...

  13. Data collection using open access technology in multicentre operational research involving patient interviews.

    Science.gov (United States)

    Shewade, H D; Chadha, S S; Gupta, V; Tripathy, J P; Satyanarayana, S; Sagili, K; Mohanty, S; Bera, O P; Pandey, P; Rajeswaran, P; Jayaraman, G; Santhappan, A; Bajpai, U N; Mamatha, A M; Maiser, R; Naqvi, A J; Pandurangan, S; Nath, S; Ghule, V H; Das, A; Prasad, B M; Biswas, M; Singh, G; Mallick, G; Jeyakumar Jaisingh, A J; Rao, R; Kumar, A M V

    2017-03-21

    Conducting multicentre operational research is challenging due to issues related to the logistics of travel, training, supervision, monitoring and troubleshooting support. This is even more burdensome in resource-constrained settings and if the research includes patient interviews. In this article, we describe an innovative model that uses open access tools such as Dropbox, TeamViewer and CamScanner for efficient, quality-assured data collection in an ongoing multicentre operational research study involving record review and patient interviews. The tools used for data collection have been shared for adaptation and use by other researchers.

  14. Researches on regenerative medicine——current state and prospect

    Institute of Scientific and Technical Information of China (English)

    WANG Zheng-guo; XIAO Kai

    2012-01-01

    Since 1980s,the rapid development of tissue engineering and stem cell research has pushed regenerative medicine to a new fastigium,and regenerative medicine has become a noticeable research field in the international biology and medicine.In China,about 100 million patients need repair and regeneration treatment every year,while the number is much larger in the world.Regenerative medicine could provide effective salvation for these patients.Both Chinese Academy of Sciences and Chinese Academy of Engineering have made roadmaps of 2010-2050 and 2011-2030 for regenerative medicine.The final goal of the two roadmaps is to make China go up to leading position in most research aspects of regenerative medicine.In accord with this strategy,the government and some enterprises have invested 3-5 billion RMB (0.5-0.8 billion USD)for the research on regenerative medicine.In order to push the translation of regenerative medicine forward - from bench to bedside,a strategic alliance has been established.and it includes 27 top-level research institutes,medical institutes,colleges,universities and enterprises in the field of stem cell and regeneration medicine.Recently the journal,Science,has published a special issue-Regenerative Medicine in China,consisting of 35 papers dealing with stem cell and regeneration,tissue engineering and regeneration,trauma and regeneration and bases for tissue repair and regenerative medicine.It is predicated that a greater breakthrough in theory and practice of regenerative medicine will be achieved in the near future (20 to 30 years).

  15. A devolved model for public involvement in the field of mental health research: case study learning.

    Science.gov (United States)

    Moule, Pam; Davies, Rosie

    2016-12-01

    Patient and public involvement in all aspects of research is espoused and there is a continued interest in understanding its wider impact. Existing investigations have identified both beneficial outcomes and remaining issues. This paper presents the impact of public involvement in one case study led by a mental health charity conducted as part of a larger research project. The case study used a devolved model of working, contracting with service user-led organizations to maximize the benefits of local knowledge on the implementation of personalized budgets, support recruitment and local user-led organizations. To understand the processes and impact of public involvement in a devolved model of working with user-led organizations. Multiple data collection methods were employed throughout 2012. These included interviews with the researchers (n = 10) and research partners (n = 5), observation of two case study meetings and the review of key case study documentation. Analysis was conducted in NVivo10 using a coding framework developed following a literature review. Five key themes emerged from the data; Devolved model, Nature of involvement, Enabling factors, Implementation challenges and Impact. While there were some challenges of implementing the devolved model it is clear that our findings add to the growing understanding of the positive benefits research partners can bring to complex research. A devolved model can support the involvement of user-led organizations in research if there is a clear understanding of the underpinning philosophy and support mechanisms are in place. © 2015 The Authors. Health Expectations Published by John Wiley & Sons Ltd.

  16. Icing Branch Current Research Activities in Icing Physics

    Science.gov (United States)

    Vargas, Mario

    2009-01-01

    Current development: A grid block transformation scheme which allows the input of grids in arbitrary reference frames, the use of mirror planes, and grids with relative velocities has been developed. A simple ice crystal and sand particle bouncing scheme has been included. Added an SLD splashing model based on that developed by William Wright for the LEWICE 3.2.2 software. A new area based collection efficiency algorithm will be incorporated which calculates trajectories from inflow block boundaries to outflow block boundaries. This method will be used for calculating and passing collection efficiency data between blade rows for turbo-machinery calculations.

  17. Nanomaterials in Lubricants: An Industrial Perspective on Current Research

    Directory of Open Access Journals (Sweden)

    Boris Zhmud

    2013-11-01

    Full Text Available This paper presents an overview on the use of various classes of nanomaterials in lubricant formulations. The following classes of nanomaterials are considered: fullerenes, nanodiamonds, ultradispersed boric acid and polytetrafluoroethylene (PTFE. Current advances in using nanomaterials in engine oils, industrial lubricants and greases are discussed. Results of numerous studies combined with formulation experience of the authors strongly suggest that nanomaterials do indeed have potential for enhancing certain lubricant properties, yet there is a long way to go before balanced formulations are developed.

  18. Current Research and Development of Chemotherapeutic Agents for Melanoma

    Directory of Open Access Journals (Sweden)

    Kyaw Minn Hsan

    2010-04-01

    Full Text Available Cutaneous malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on conventional chemotherapeutic drugs for melanoma treatment, by a single or combinational agent approach, but also summarizes some potential novel phytoagents discovered from dietary vegetables or traditional herbal medicines as alternative options or future medicine for melanoma prevention. We explore the mode of actions of these natural phytoagents against metastatic melanoma.

  19. Conceptual knowledge representation: A cross-section of current research.

    Science.gov (United States)

    Rogers, Timothy T; Wolmetz, Michael

    2016-01-01

    How is conceptual knowledge encoded in the brain? This special issue of Cognitive Neuropsychology takes stock of current efforts to answer this question through a variety of methods and perspectives. Across this work, three questions recur, each fundamental to knowledge representation in the mind and brain. First, what are the elements of conceptual representation? Second, to what extent are conceptual representations embodied in sensory and motor systems? Third, how are conceptual representations shaped by context, especially linguistic context? In this introductory article we provide relevant background on these themes and introduce how they are addressed by our contributing authors.

  20. [Musculoskeletal shock wave therapy--current database of clinical research].

    Science.gov (United States)

    Rompe, J D; Buch, M; Gerdesmeyer, L; Haake, M; Loew, M; Maier, M; Heine, J

    2002-01-01

    During the past decade application of extracorporal shock waves became an established procedure for the treatment of various musculoskeletal diseases in Germany. Up to now the positive results of prospective randomised controlled trials have been published for the treatment of plantar fasciitis, lateral elbow epicondylitis (tennis elbow), and of calcifying tendinitis of the rotator cuff. Most recently, contradicting results of prospective randomised placebo-controlled trials with adequate sample size calculation have been reported. The goal of this review is to present information about the current clinical database on extracorporeal shock wave treatment (ESWT).

  1. Current research on drugs and vaccines for fighting bird flu.

    Science.gov (United States)

    Wiwanitkit, Viroj

    2007-12-01

    Bird flu, or avian flu, caused by the H5N1 virus, is of concern worldwide. The antiviral drugs oseltamivir and zanamivir have been used to treat human cases, and resistance has been reported. Studies on the molecular mechanisms of antiviral resistance are needed to understand the problem and to aid future drug development. Control of a major outbreak would require a vaccine, but current manufacturing technology is not adequate to support influenza vaccine production in the event of an avian influenza outbreak.

  2. Incredible Years parenting interventions: current effectiveness research and future directions.

    Science.gov (United States)

    Gardner, Frances; Leijten, Patty

    2017-06-01

    The Incredible Years parenting intervention is a social learning theory-based programme for reducing children's conduct problems. Dozens of randomized trials, many by independent investigators, find consistent effects of Incredible Years on children's conduct problems across multiple countries and settings. However, in common with other interventions, these average effects hide much variability in the responses of individual children and families. Innovative moderator research is needed to enhance scientific understanding of why individual children and parents respond differently to intervention. Additionally, research is needed to test whether there are ways to make Incredible Years more effective and accessible for families and service providers, especially in low resource settings, by developing innovative delivery systems using new media, and by systematically testing for essential components of parenting interventions. Copyright © 2017. Published by Elsevier Ltd.

  3. Current electroconvulsive therapy practice and research in the geriatric population

    Science.gov (United States)

    Kerner, Nancy; Prudic, Joan

    2014-01-01

    SUMMARY Electroconvulsive therapy (ECT) is utilized worldwide for various severe and treatment-resistant psychiatric disorders. Research studies have shown that ECT is the most effective and rapid treatment available for elderly patients with depression, bipolar disorder and psychosis. For patients who suffer from intractable catatonia and neuroleptic malignant syndrome, ECT can be life saving. For elderly patients who cannot tolerate or respond poorly to medications and who are at a high risk for drug-induced toxicity or toxic drug interactions, ECT is the safest treatment option. Organic causes are frequently associated with late-life onset of neuropsychiatric conditions, such as parkinsonism, dementia and stroke. ECT has proven to be efficacious even when these conditions are present. During the next decade, research studies should focus on the use of ECT as a synergistic therapy, to enhance other biological and psychological treatments, and prevent symptom relapse and recurrence. PMID:24778709

  4. Opening the "black box" of current creativity research

    DEFF Research Database (Denmark)

    Hoffmann Birk, Rasmus; Ernø, Steffen

    value" or none at all. Creativity was mostly measured with different types of divergent thinking tests. There appears to be a lack of deeper theoretical and methodological discussions of creativity in the literature, which creates a disconnection between definitions, methodologies and the interpretation......This presentation aims to problematise the ways in which creativity is defined and measured in recent studies on the topic. For this purpose, we analyzed 58 articles on creativity, selected from within the sub-fields of neuropsychology, psychometrics and developmental psychology published from 2009......-2012. The sub-fields were chosen because of their prominence in psychological research and research on creativity. The articles were procured from the PsycINFO database, with selection criteria being that they must be peer-reviewed and empirical studies. Typical definitions of creativity were "novelty plus...

  5. CYBERQUEER – MAJOR TOPICS AND ISSUES IN CURRENT RESEARCH

    Directory of Open Access Journals (Sweden)

    SIMONA RODAT

    2014-12-01

    Full Text Available The emergence of the opportunities opened by the internet raises also questions of interest for research regarding the extent to which these have an impact on the formations of non heterosexual life and on the experience of marginalised sexual identities. There have been different approaches in this regard and answers vary from optimistic and utopian appraisals concerning cyberspace in the early 90s to the more moderate and sceptic visions in the 2000s. Starting from this framework of debates, the present paper aims to explore the meaning of the term “cyberqueer”, including the theoretical context of its occurrence, to briefly highlight some critical considerations relating to cyberqueer research and to look over the main recurrent themes linked up with this concept, such as queer and cyberqueer identity, body and (disembodied practices and the forthcoming process of blurring the dividing boundaries between real/virtual, online/offline and public/private

  6. AAS Nova and Astrobites: Making current astronomy research accessible

    Science.gov (United States)

    Kohler, Susanna; Astrobites Team

    2016-10-01

    AAS Nova and Astrobites are two resources available for astronomers, astronomy students, and astronomy enthusiasts to keep up with some of the most recent research published across the field of astronomy. Both supported by the AAS, these two daily astrophysical literature blogs provide accessible summaries of recent publications on the arXiv and in AAS journals. We present the goals, content, and readership of AAS Nova and Astrobites, and discuss how they might be used as tools in the undergraduate classroom.

  7. Current Status and Trend of Forest Hydrological Services Market Research

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Of the many services that forests provide, hydrological services are among the most valuable, and it becomes more scarce with the growing demands by human beings. As a kind of incentive measure for protecting forest, forest hydrological services markets have been developed in many countries around the world and some valuable experiences have been achieved. The paper reviews the experiments carried out in the world and their research findings on forest hydrological services market, and presents the issues to...

  8. Ubiquitous Wireless Computing: Current Research Progress, Challenging, and Future Directions

    OpenAIRE

    Elyas, Palantei

    2014-01-01

    - The aggressive research activities and generous studies focusing on the ubiquitous mobile computing carried-out during the last two decades have gained very tremendous outcomes to apply in broad areas of modern society lives. In the near future, the computing technology application is highly possible to emerge as the dominant method to connect any objects to the global ICT infrastructure, the internet. This talk mainly discusses several R&D achievements performed during the last five yea...

  9. Music therapy in cardiac health care: current issues in research.

    Science.gov (United States)

    Hanser, Suzanne B

    2014-01-01

    Music therapy is a service that has become more prevalent as an adjunct to medical practice-as its evidence base expands and music therapists begin to join the cardiology team in every phase of care, from the most serious cases to those maintaining good heart health. Although applications of music medicine, primarily listening to short segments of music, are capable of stabilizing vital signs and managing symptoms in the short-term, music therapy interventions by a qualified practitioner are showing promise in establishing deeper and more lasting impact. On the basis of mind-body approaches, stress/coping models, the neuromatrix theory of pain, and entrainment, music therapy capitalizes on the ability of music to affect the autonomic nervous system. Although only a limited number of randomized controlled trials pinpoint the efficacy of specific music therapy interventions, qualitative research reveals some profound outcomes in certain individuals. A depth of understanding related to the experience of living with a cardiovascular disease can be gained through music therapy approaches such as nonverbal music psychotherapy and guided imagery and music. The multifaceted nature of musical responsiveness contributes to strong individual variability and must be taken into account in the development of research protocols for future music therapy and music medicine interventions. The extant research provides a foundation for exploring the many potential psychosocial, physiological, and spiritual outcomes of a music therapy service for cardiology patients.

  10. The Communication Research in Spain. Historical evolution and current challenges

    Directory of Open Access Journals (Sweden)

    Dr. Manuel Martínez Nicolás - manuel.martinez.nicolas@urjc.es

    2009-01-01

    Full Text Available We propose in this paper an approach to the history of Communication Research in Spain, taking into account the scientific production and the structure and historical context in which the scientific community interested in this field have performed their work. For this task we have established a temporary frame beginning from the moment communication became an autonomous field of research and education in Spain, during the mid-sixties, until present time. This period has been divided into three stages, typically defined as emergence, consolidation and development (or maturing of communication studies in Spain. In each of these stages, the scientific community interested in communication research have worked in different social, academic and epistemic or scientific contexts. These particular conditions contribute to understanding the different orientations which have inspired historical communication research in Spain (research objects, theoretical and methodological approaches, contributions and limitations.Traducción supervisada por la Dda. María Teresa Durán Sánchez (ULPGC.En este trabajo se propone una aproximación a la historia de la investigación sobre comunicación en España poniendo en relación la producción científica con las características, estructura y condiciones históricas en las que ha desempeñado su trabajo la comunidad científica interesada en este ámbito. Para ello, se establece un marco temporal que arranca en el momento de la constitución de la comunicación como campo de investigación (y de docencia autónomo, a mediados de la década de los sesenta, y llega hasta la actualidad. Consideramos que en el curso de este periodo pueden distinguirse no menos de tres etapas, que convencionalmente se han denominado de emergencia, consolidación y desarrollo (o maduración de los estudios sobre comunicación en España. En cada una de estas etapas, la comunidad científica interesada en la investigación comunicativa

  11. Alaskan Peninsula Cenozoic stratigraphy: stratigraphic sequences and current research

    Energy Technology Data Exchange (ETDEWEB)

    Allison, R.C.; Armentrout, J.M.

    1985-04-01

    Geology of the Alaska Peninsula-Island Arc and Continental Margin, by C.A. Burk, is the principal reference for stratigraphic studies on the Alaska Peninsula. Burk mapped the Phanerozoic stratigraphy and provided a geologic history and structural interpretation of the area between Wide Bay and Unimak Island. Cenozoic rocks were mapped as three unconformity-bounded sequences. Recognition of specific formations was difficult due to similarity of lithofacies, isolated outcrops, rapid facies changes, and alteration and burial by young volcanics. Consequently, megafossil assemblages were relied upon to facilitate correlations between study areas. The three unconformity-bounded Cenozoic sequences are: (1) the Paleogene Beaver Bay Group consisting of three formations: the dominantly nonmarine Tolstoi Formation, the dominantly marine Stepovak Formation, and the volcanic Meshik Formation. Current work suggests these units are at least in part coeval facies of late Paleocene through Oligocene age. (2) The Neogene Bear Lake Formation consisting of the lower Unga Conglomerate Member and an unnamed upper member. Rapid facies changes and incorrect reports of fossil occurrence have resulted in confusion of stratigraphic relationships within this sequence of middle to late Miocene age. (3) A late Neogene informally defined upper sequence consisting of interbedded marginal marine, coastal-plain, and volcanic facies. Current work suggests this sequence is Pliocene through Pleistocene in age.

  12. Current Status and Research into Overcoming Limitations of Capsule Endoscopy.

    Science.gov (United States)

    Kwack, Won Gun; Lim, Yun Jeong

    2016-01-01

    Endoscopic investigation has a critical role in the diagnosis and treatment of gastrointestinal (GI) diseases. Since 2001, capsule endoscopy (CE) has been available for small-bowel exploration and is under continuous development. During the past decade, CE has achieved impressive improvements in areas such as miniaturization, resolution, and battery life. As a result, CE is currently a first-line tool for the investigation of the small bowel in obscure gastrointestinal bleeding and is a useful alternative to wired enteroscopy. Nevertheless, CE still has several limitations, such as incomplete examination and limited diagnostic and therapeutic capabilities. To resolve these problems, many groups have suggested several models (e.g., controlled CO2 insufflation system, magnetic navigation system, mobile robotic platform, tagging and biopsy equipment, and targeted drug-delivery system), which are in development. In the near future, new technological advances will improve the capabilities of CE and broaden its spectrum of applications not only for the small bowel but also for the colon, stomach, and esophagus. The purpose of this review is to introduce the current status of CE and to review the ongoing development of solutions to address its limitations.

  13. Supporting public involvement in research design and grant development: a case study of a public involvement award scheme managed by a National Institute for Health Research (NIHR) Research Design Service (RDS).

    Science.gov (United States)

    Boote, Jonathan D; Twiddy, Maureen; Baird, Wendy; Birks, Yvonne; Clarke, Clare; Beever, Daniel

    2015-10-01

    It is good practice for the public to be involved in developing health research. Resources should be available for researchers to fund the involvement of the public in the development of their grants. To describe a funding award scheme to support public involvement in grant development, managed by an NIHR Research Design Service (RDS). Case examples of how the award contributed to successful grant applications and findings from a recent evaluation of the scheme are presented. A case study of resource provision to support public involvement activities in one region of England. University and NHS-based researchers, and members of the public. Between 2009 and 2012, the RDS approved 45 public involvement funding awards (totalling nearly £19,000). These awards contributed to 27 submitted applications at the time of writing, of which 11 were successful (totalling over £7.5 million). The evaluation revealed difficulties encountered by some researchers when involving the public in grant development, which led to suggestions about how the scheme could be improved. This award scheme represents an efficient method of providing researchers with resources to involve the public in grant development and would appear to represent good value for money. © 2013 John Wiley & Sons Ltd.

  14. How Music Can Influence the Body: Perspectives From Current Research

    Directory of Open Access Journals (Sweden)

    Imogen Nicola Clark

    2016-07-01

    Full Text Available Music is widely used by people of all ages as a stimulant and relaxant to manage everyday situations. Whether to motivate us for exercise or to help us unwind after a busy day, we seem to have an intuitive understanding about the influences music has on our bodies. The body’s responses to music are both conscious and unconscious, involving entrainment with rhythm, hormonal and neurological reactions, and changes in mood, emotion, and pain perception. This article explains these physiological responses to music and provides guidelines for consideration when selecting music to evoke desired bodily responses. Applications using music in rehabilitation are also provided to illustrate health-promoting qualities of music.

  15. Current Developments in Research on the Teaching of Grammar

    Institute of Scientific and Technical Information of China (English)

    Hossein Nassaji; Sandra Fotos

    2006-01-01

    @@ Continued from Issue 61 Textual Enhancement There are a number of studies that have investigated the effects of textual enhancement on drawing the learner's attention to grammar, and the method has been described as the least explicit and the least intrusive method of focus on form (Doughty & Varela, 1998). It involves highlighting certain features of input that might go unnoticed under normal circumstances by typographically manipulating them through boldfacing, italicizing, underlining, or capitalizing. The assumption is that such manipulations enhance the perceptual saliency of the target structures, and this, hence, increases their chance of being noticed. A related technique is the provision of numerous instances of target linguistic forms in the input, called an input flood (Trahey & While, 1993). Again,the assumption is that frequent exposure to target items enhances their saliency and hence results in noticing the forms (Schmidt, 1990; Sharwood Smith, 1993). Whereas studies by Doughty (1991) and Fotos (1994) reported positive results in terms of awareness of target structures and proficiency gains resulting from textually enhanced structures, a study by White (1998) did not show that learners who received textually enhanced input differed significantly in their ability to use the target structure compared with those who did not.White concluded that the method of enhancement may not have been sufficiently explicit to draw the learners' attention to the type of linguistic features that involved L1-L2 contrasts. Similarly, Leow (2001) investigated the effects of textual enhancement on learning Spanish formal imperatives and found no advantage for enhanced text over unenhanced text.Finally, Izumi (2001) compared two types of focus on form strategies, output and visual input enhancement, on the learning of English relativization by adult ESL learners, finding that those who produced output developed more than those merely received input. However, the visual

  16. Current knowledge on the genetics of autism and propositions for future research.

    Science.gov (United States)

    Bourgeron, Thomas

    2016-01-01

    Autism spectrum disorders (ASD) are a heterogeneous group of neuropsychiatric disorders characterized by problems in social communication, as well as by the presence of restricted interests, stereotyped and repetitive behaviours. In the last 40years, genetic studies have provided crucial information on the causes of ASD and its diversity. In this article, I will first review the current knowledge on the genetics of ASD and then suggest three propositions to foster research in this field. Twin and familial studies estimated the heritability of ASD to be 50%. While most of the inherited part of ASD is captured by common variants, our current knowledge on the genetics of ASD comes almost exclusively from the identification of highly penetrant de novo mutations through candidate gene or whole exome/genome sequencing studies. Approximately 10% of patients with ASD, especially those with intellectual disability, are carriers of de novo copy-number (CNV) or single nucleotide variants (SNV) affecting clinically relevant genes for ASD. Given the function of these genes, it was hypothesized that abnormal synaptic plasticity and failure of neuronal/synaptic homeostasis could increase the risk of ASD. In addition to these discoveries, three propositions coming from institutions, researchers and/or communities of patients and families can be made to foster research on ASD: (i) to use more dimensional and quantitative data than diagnostic categories; (ii) to increase data sharing and research on genetic and brain diversity in human populations; (iii) to involve patients and relatives as participants for research. Hopefully, this knowledge will lead to a better diagnosis, care and integration of individuals with ASD.

  17. Munchausen by Internet: Current Research and Future Directions

    Science.gov (United States)

    Taylor, Jacqui

    2012-01-01

    Background The Internet has revolutionized the health world, enabling self-diagnosis and online support to take place irrespective of time or location. Alongside the positive aspects for an individual’s health from making use of the Internet, debate has intensified on how the increasing use of Web technology might have a negative impact on patients, caregivers, and practitioners. One such negative health-related behavior is Munchausen by Internet. Objective Munchausen by Internet occurs when medically well individuals fake recognized illnesses in virtual environments, such as online support groups. This paper focuses on the aspect of Munchausen by Internet in which individuals actively seek to disrupt groups for their own satisfaction, which has not yet been associated with the wider phenomena of Internet trolls (users who post with the intention of annoying someone or disrupting an online environment). Methods A wide-ranging review was conducted to investigate the causes and impacts of online identity deception and Munchausen by Internet drawing on academic research and case studies reported online and in the media. Results The limited research relating to motivation, opportunity, detection, effects, and consequences of Munchausen by Internet is highlighted and it is formally linked to aspects of trolling. Case studies are used to illustrate the phenomenon. What is particularly worrying is the ease with which the deception can be carried out online, the difficulty in detection, and the damaging impact and potential danger to isolated victims. Conclusions We suggest ways to deal with Munchausen by Internet and provide advice for health group facilitators. We also propose that Munchausen by Internet and Munchausen by Internet trolling should be formally acknowledged in a revised version of the Diagnostic and Statistical Manual DSM-5. This will assist in effectively identifying and minimizing the growth of this behavior as more people seek reassurance and support

  18. Current status of neutron activation analysis in HANARO Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yong Sam; Moon, Jong Hwa; Sohn, Jae Min [Korea Atomic Energy Research Institute, Daejeon (Korea)

    2003-03-01

    The facilities for neutron activation analysis in the HANARO (Hi-flux Advanced Neutron Application Research Reactor) are described and the main applications of NAA (Neutron Activation Analysis) are reviewed. The sample irradiation tube, automatic and manual pneumatic transfer system were installed at three irradiation holes of HANARO at the end of 1995. The performance of the NAA facility was examined to identify the characteristics of the tube transfer system, irradiation sites and custom-made polyethylene irradiation capsule. The available thermal neutron fluxes at irradiation sites are in the range of 3 x 10{sup 13} - 1 x 10{sup 14} n/cm{sup 2}{center_dot}s and cadmium ratios are in 15 - 250. For an automatic sample changer for gamma-ray counting, a domestic product was designed and manufactured. An integrated computer program (Labview) to analyse the content was developed. In 2001, PGNAA (Prompt Gamma Neutron Activation Analysis) facility has been installed using a diffracted neutron beam of ST1. NAA has been applied in the trace component analysis of nuclear, geological, biological, environmental and high purity materials, and various polymers for research and development. The improvement of analytical procedures and establishment of an analytical quality control and assurance system were studied. Applied research and development for the environment, industry and human health by NAA and its standardization were carried out. For the application of the KOLAS (Korea Laboratory Accreditation Scheme), evaluation of measurement uncertainty and proficiency testing of reference materials were performed. Also to verify the reliability and to validate analytical results, intercomparison studies between laboratories were carried out. (author)

  19. Current Research in Aircraft Tire Design and Performance

    Science.gov (United States)

    Tanner, J. A.; Mccarthy, J. L.; Clark, S. K.

    1981-01-01

    A review of the tire research programs which address the various needs identified by landing gear designers and airplane users is presented. The experimental programs are designed to increase tire tread lifetimes, relate static and dynamic tire properties, establish the tire hydroplaning spin up speed, study gear response to tire failures, and define tire temperature profiles during taxi, braking, and cornering operations. The analytical programs are aimed at providing insights into the mechanisms of heat generation in rolling tires and developing the tools necessary to streamline the tire design process and to aid in the analysis of landing gear problems.

  20. Current Status of Dengue Therapeutics Research and Development.

    Science.gov (United States)

    Low, Jenny G H; Ooi, Eng Eong; Vasudevan, Subhash G

    2017-03-01

    Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  1. 76 FR 38399 - Assessing the Current Research, Policy, and Practice Environment in Public Health Genomics

    Science.gov (United States)

    2011-06-30

    ... HUMAN SERVICES Centers for Disease Control and Prevention Assessing the Current Research, Policy, and..., and other information helpful to assess the current research, policy, and practice environment in... Control and Prevention (CDC) has worked to integrate genomics into public health research, policy,...

  2. Strength and conditioning in tennis: current research and practice.

    Science.gov (United States)

    Reid, Machar; Schneiker, Knut

    2008-06-01

    Virtually all professional tennis players are in continuous pursuit of enhanced performance. With the modern game becoming increasingly dynamic and tournament schedules no less demanding, the importance of physical fitness is well accepted. Indeed, most professional tennis players resource strength and conditioning specialists on a full- or part-time basis. As tennis play is characterised by intricate bio-energetics, planning specific strength and conditioning interventions represents a significant challenge for the specialist. Further, where game physiology and mechanics have been described extensively, critiques of the efficacy of different training initiatives are far less common. This review therefore considers the current scientific, tennis-specific fitness training evidence base in light of contemporary conditioning, and more particularly resistance training, practices.

  3. Caffeine and cardiovascular diseases: critical review of current research.

    Science.gov (United States)

    Zulli, Anthony; Smith, Renee M; Kubatka, Peter; Novak, Jan; Uehara, Yoshio; Loftus, Hayley; Qaradakhi, Tawar; Pohanka, Miroslav; Kobyliak, Nazarii; Zagatina, Angela; Klimas, Jan; Hayes, Alan; La Rocca, Giampiero; Soucek, Miroslav; Kruzliak, Peter

    2016-06-01

    Caffeine is a most widely consumed physiological stimulant worldwide, which is consumed via natural sources, such as coffee and tea, and now marketed sources such as energy drinks and other dietary supplements. This wide use has led to concerns regarding the safety of caffeine and its proposed beneficial role in alertness, performance and energy expenditure and side effects in the cardiovascular system. The question remains "Which dose is safe?", as the population does not appear to adhere to the strict guidelines listed on caffeine consumption. Studies in humans and animal models yield controversial results, which can be explained by population, type and dose of caffeine and low statistical power. This review will focus on comprehensive and critical review of the current literature and provide an avenue for further study.

  4. [Organ cryopreservation: current status of research carried out in Grenoble].

    Science.gov (United States)

    Descotes, J L; Payen, E; Rambeaud, J J; Peuridieu, J F; Baudot, A; Odin, J; Mazuer, J; Boutron, P; Delon-Martin, C; Dupeyre, R

    1995-12-01

    After discussing the problem of organ cryopreservation and reviewing the current data available on this subject, the Grenoble project is presented. Physical and biological studies have been combined with experimentation of autologous renal transplantation in rabbits to assess the functional value of the retransplanted organ after treatment and cooling. Renal resistances are measured during perfusion of the kidney with the cryoprotective solution. In order to verify the homogeneity of the cryoprotector concentration in the organ, on NMR spectral imaging test has been developed. A new rapid imaging method now allows real time monitoring of concentration variations during perfusion. In addition to concentration and homogeneity, analysis of local spectra also provides information about the local temperature de the kidney.

  5. Ethical Standards of Scientific Research Involving Human Subjects in Brazil: Perspectives Concerning Psychology

    Directory of Open Access Journals (Sweden)

    Selma Leitão

    2015-01-01

    Full Text Available AbstractBrazilian associations for research in human, social and applied social sciences have long sought ethical aspects regulation compatible with the epistemological, theoretical and methodological specificities of these sciences. Consequently, the Brazilian regulatory system (Research Ethics Committees/CEPs of the National Research Ethics Commission/CONEP is currently undergoing an important review process. This article presents the positions taken by the National Association of Research and Postgraduate Studies in Psychology - ANPEPP. The article: (1 highlights the origins of the current ethics review model, based on biomedical research; (2 summarizes criticisms recurrent to this model; (3 identifies the directions required for the improvement of the system; and (4 lists the challenges to be overcome in the current process of creating specific regulations for the human and social sciences. The considerations presented highlight two crucial points that challenge the construction of a specific resolution for research ethics in the human and social sciences: (1 the clear characterization of what is meant by 'research in the human and social sciences' - and that would, therefore, have its ethical review regulated from the perspective of the specific resolution for the human and social sciences; and (2 the definition of parameters from which different risk levels in studies can be identified.

  6. Sediment pollution of the Elbe River side structures - current research

    Science.gov (United States)

    Chalupova, Dagmar; Janský, Bohumír

    2016-04-01

    The contribution brings the summarized results of a long-term research on sediment pollution of side structures of the Elbe River over the last 14 years. The investigation has been focused on old anthropogenic pollution of sediment cores taken from fluvial lakes and floodplain, as the sampling of deeper sediments outside the riverbed is not a part of systematic monitoring of sediment pollution of the Elbe. The Elbe River floodplain has been influenced by human activities since the Middle Ages, but the main anthropogenic pollution have been produced in the 20th century. The studied localities were chosen with the respect to the distance from the source of industrial pollution, the intensity of hydrological communication with the river and the surrounding landuse to determine the extend and the level of anthropogenic contamination in the Elbe River floodplain ecosystem. Apart from bathymetric measurements, observation of the hydrological regime in several fluvial lakes or water quality sampling at some localities, the research was focused above all on determination of metal concentrations (Ag, Cd, Cr, Cu, Fe, Hg, Mn, Pb, Zn) in all taken sediment cores, specific organic compounds (PCBs, DDT, HCH, HCB, PAHs etc.), total organic carbon at some localities and grain structure analyses. The data were also compared with the results of systematic sediment monitoring from the nearest riverbed sampling stations on the Elbe River. The highest concentrations of metals and specific organic compounds were determined in the sediments taken from fluvial lakes and floodplain (Zimní přístav PARAMO, Rosice fuvial Lake, Libiš pool etc.) situated in the vicinity of the main Elbe River polluters - Synthesia chemical plant and PARAMO refinery in Pardubice or Spolana chemical plant near Neratovice. However, there was also determined a significant role of the hydrological communication with the river proved with lower sediment pollution in separated localities. The realization of the

  7. Guidelines from the Consumer: Improving Consumer Involvement in Research and Training for Persons with Mental Retardation.

    Science.gov (United States)

    Heller, Tamar; And Others

    1996-01-01

    Interviews with 22 adults with mental retardation suggest that, although they and other individuals with mental retardation have participated in various roles in research and training, there are many barriers to meaningful consumer involvement (such as professional jargon) and there is a need to bring out individuals' strengths and capabilities.…

  8. Alaska Native people's perceptions, understandings, and expectations for research involving biological specimens

    Directory of Open Access Journals (Sweden)

    Vanessa Y. Hiratsuka

    2012-05-01

    Full Text Available Objectives. Members of racially and ethnically diverse groups have been persistently underrepresented in biomedical research in general, possibly due to mistrust with the medical and research community. This article describes the perceptions, understandings, and expectations of Alaska Native people about research involving the collection and storage of biological specimens. Study design. Stratified focus groups. Methods. Twenty-nine focus groups with Alaska Native people (n = 178 were held in 14 locations using a semi-structured moderator guide. ATLAS.ti was used for thematic analysis through iterative readings and coding. Alaska Native peoples’ perceptions, understandings, and expectations of researcher beneficence, informed consent processes, and provision of research findings were elicited. Results and conclusions. Alaska Native people desired extensive disclosure of information beyond that typically provided in consent and results dissemination processes. Information germane to the motivation and intent of researchers and specifics of specimen storage and destruction were specifically requested. A clear and extensive process of informed consent and continued improvements in sharing results may enhance the transparency of research intent, conduct, and use of obtained results among Alaska Native people. Meeting expectations may improve relationships between researchers and the Alaska Native population which could result in increased research participation. Our findings offer a guide for researchers and communities when planning and implementing research with biological specimens.

  9. The Development and Current State of Translation Process Research

    DEFF Research Database (Denmark)

    Lykke Jakobsen, Arnt

    2014-01-01

    which simultaneously tracks the translator’s eye movements across a screen displaying both a source text and the translator’s emerging translation. This research method was developed as a means of qualifying and strengthening translation process hypotheses based on verbal reports by providing additional...... remains inaccessible to outside observation. What mental processes underlie measurable (micro)behaviour can only be inferred. A multi-methodological approach is clearly called for in order to capture the full complexity of translation, and translation studies must be open to extend its curiosity beyond...... itself, into regions like cognitive psychology, psycho- and neurolinguistics, and neuroscience, where the interest in what goes on in our heads is also very strong....

  10. Microarrays—Current and Future Applications in Biomedical Research

    Directory of Open Access Journals (Sweden)

    Ulrich Certa

    2011-11-01

    Full Text Available Microarrays covers research where microarrays are applied to address complex biological questions. This new open access journal publishes articles where novel applications or state-of-the art technology developments in the field are reported. In addition, novel methods or data analysis algorithms are under the scope of Microarrays. This journal will serve as a platform for fast and efficient sharing of data within this large user community. As one of the first microarray users in Europe back in 1996, I am proud to serve as Editor-in-Chief and I believe we have assembled a highly proficient Editorial Board, responsible for a fair and fast peer-review of articles.

  11. Current Status of Japanese Global Precipitation Measurement (GPM) Research Project

    Science.gov (United States)

    Kachi, Misako; Oki, Riko; Kubota, Takuji; Masaki, Takeshi; Kida, Satoshi; Iguchi, Toshio; Nakamura, Kenji; Takayabu, Yukari N.

    2013-04-01

    The Global Precipitation Measurement (GPM) mission is a mission led by the Japan Aerospace Exploration Agency (JAXA) and the National Aeronautics and Space Administration (NASA) under collaboration with many international partners, who will provide constellation of satellites carrying microwave radiometer instruments. The GPM Core Observatory, which carries the Dual-frequency Precipitation Radar (DPR) developed by JAXA and the National Institute of Information and Communications Technology (NICT), and the GPM Microwave Imager (GMI) developed by NASA. The GPM Core Observatory is scheduled to be launched in early 2014. JAXA also provides the Global Change Observation Mission (GCOM) 1st - Water (GCOM-W1) named "SHIZUKU," as one of constellation satellites. The SHIZUKU satellite was launched in 18 May, 2012 from JAXA's Tanegashima Space Center, and public data release of the Advanced Microwave Scanning Radiometer 2 (AMSR2) on board the SHIZUKU satellite was planned that Level 1 products in January 2013, and Level 2 products including precipitation in May 2013. The Japanese GPM research project conducts scientific activities on algorithm development, ground validation, application research including production of research products. In addition, we promote collaboration studies in Japan and Asian countries, and public relations activities to extend potential users of satellite precipitation products. In pre-launch phase, most of our activities are focused on the algorithm development and the ground validation related to the algorithm development. As the GPM standard products, JAXA develops the DPR Level 1 algorithm, and the NASA-JAXA Joint Algorithm Team develops the DPR Level 2 and the DPR-GMI combined Level2 algorithms. JAXA also develops the Global Rainfall Map product as national product to distribute hourly and 0.1-degree horizontal resolution rainfall map. All standard algorithms including Japan-US joint algorithm will be reviewed by the Japan-US Joint

  12. Plasma medicine—current state of research and medical application

    Science.gov (United States)

    Weltmann, K.-D.; von Woedtke, Th

    2017-01-01

    Plasma medicine means the direct application of cold atmospheric plasma (CAP) on or in the human body for therapeutic purposes. Further, the field interacts strongly with results gained for biological decontamination. Experimental research as well as first practical application is realized using two basic principles of CAP sources: dielectric barrier discharges (DBD) and atmospheric pressure plasma jets (APPJ). Originating from the fundamental insights that the biological effects of CAP are most probably caused by changes of the liquid environment of cells, and are dominated by reactive oxygen and nitrogen species (ROS, RNS), basic mechanisms of biological plasma activity are identified. It was demonstrated that there is no increased risk of cold plasma application and, above all, there are no indications for genotoxic effects. The most important biological effects of cold atmospheric pressure plasma were identified: (1) inactivation of a broad spectrum of microorganisms including multidrug resistant ones; (2) stimulation of cell proliferation and tissue regeneration with lower plasma treatment intensity (treatment time); (3) inactivation of cells by initialization of programmed cell death (apoptosis) with higher plasma treatment intensity (treatment time). In recent years, the main focus of clinical applications was in the field of wound healing and treatment of infective skin diseases. First CAP sources are CE-certified as medical devices now which is the main precondition to start the introduction of plasma medicine into clinical reality. Plasma application in dentistry and, above all, CAP use for cancer treatment are becoming more and more important research fields in plasma medicine. A further in-depth knowledge of control and adaptation of plasma parameters and plasma geometries is needed to obtain suitable and reliable plasma sources for the different therapeutic indications and to open up new fields of medical application.

  13. Research on Field Emission and Dark Current in ILC Cavities

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Kexin; Li, Yongming; Palczewski, Ari; Geng, Rongli

    2013-09-01

    Field emission and dark current are issues of concern for SRF cavity performance and SRF linac operation. Complete understanding and reliable control of the issue are still needed, especially in full-scale multi-cell cavities. Our work aims at developing a generic procedure for finding an active field emitter in a multi-cell cavity and benchmarking the procedure through cavity vertical test. Our ultimate goal is to provide feedback to cavity preparation and cavity string assembly in order to reduce or eliminate filed emission in SRF cavities. Systematic analysis of behaviors of field emitted electrons is obtained by ACE3P developed by SLAC. Experimental benchmark of the procedure was carried out in a 9-cell cavity vertical test at JLab. The energy spectrum of Bremsstrahlung X-rays is measured using a NaI(Tl) detector. The end-point energy in the X-ray energy spectrum is taken as the highest kinetic electron energy to predict longitudinal position of the active field emitter. Angular location of the field emitter is determined by an array of silicon diodes around irises of the cavity. High-resolution optical inspection was conducted at the predicted field emitter location.

  14. [Depression and sleep--the status of current research].

    Science.gov (United States)

    Riemann, D; Schnitzler, M; Hohagen, F; Berger, M

    1994-12-01

    Abnormalities of REM sleep, i.e. shortening of REM latency, lengthening of the duration of the first REM period and heightening of REM density, which are frequently observed in patients with a Major Depressive Disorder (MDD), have attracted considerable interest. Initial hopes that these aberrant patterns of sleep constitute specific markers for the primary/endogenous subtype of depression have not been fulfilled. The specificity of REM sleep disinhibition for depression in comparison to other psychopathological groups is also challenged. Demographic variables like age and sex exert strong influences on sleep physiology and must be controlled when searching for specific markers of depressed sleep. It is still an open question whether abnormalities of sleep are state-markers or trait-markers of depression. Beyond baseline studies, the cholinergic REM induction test (CRIT) indicated a heightened responsitivity of the REM sleep system to cholinergic challenge in depression compared with healthy controls and other psychopathological groups, with the exception of schizophrenia. A special role for REM sleep in depression is supported by the well known REM sleep suppressing effect of most antidepressants. The antidepressant effect of selective REM deprivation by awakenings stresses the importance of mechanisms involved in REM sleep regulation for the understanding of the pathophysiology of depressive disorders. The positive effect of total sleep deprivation on depressive mood which can be reversed by daytime naps, furthermore emphasizes relationships between sleep and depression. Experimental evidence as described above instigated several theories like the REM deprivation hypothesis, the 2-process model and the reciprocal interaction model of nonREM-REM sleep regulation to explain the deviant sleep pattern of depression. The different models will be discussed with reference to empirical data gathered in the field.

  15. Wave-current interactions at the FloWave Ocean Energy Research Facility

    Science.gov (United States)

    Noble, Donald; Davey, Thomas; Steynor, Jeffrey; Bruce, Tom; Smith, Helen; Kaklis, Panagiotis

    2015-04-01

    Physical scale model testing is an important part of the marine renewable energy development process, allowing the study of forces and device behaviour in a controlled environment prior to deployment at sea. FloWave is a new state-of-the-art ocean energy research facility, designed to provide large scale physical modelling services to the tidal and wave sector. It has the unique ability to provide complex multi-directional waves that can be combined with currents from any direction in the 25m diameter circular tank. The facility is optimised for waves around 2s period and 0.4m height, and is capable of generating currents upwards of 1.6m/s. This offers the ability to model metocean conditions suitable for most renewable energy devices at a typical scale of between 1:10 and 1:40. The test section is 2m deep, which can be classed as intermediate-depth for most waves of interest, thus the full dispersion equation must be solved as the asymptotic simplifications do not apply. The interaction between waves and currents has been studied in the tank. This has involved producing in the tank sets of regular waves, focussed wave groups, and random sea spectra including multi-directional sea states. These waves have been both inline-with and opposing the current, as well as investigating waves at arbitrary angles to the current. Changes in wave height and wavelength have been measured, and compared with theoretical results. Using theoretical wave-current interaction models, methods have been explored to "correct" the wave height in the central test area of the tank when combined with a steady current. This allows the wave height with current to be set equal to that without a current. Thus permitting, for example, direct comparison of device motion response between tests with and without current. Alternatively, this would also permit a specific wave height and current combination to be produced in the tank, reproducing recorded conditions at a particular site of interest. The

  16. Involving High School Students in Computational Physics University Research: Theory Calculations of Toluene Adsorbed on Graphene

    OpenAIRE

    2016-01-01

    To increase public awareness of theoretical materials physics, a small group of high school students is invited to participate actively in a current research projects at Chalmers University of Technology. The Chalmers research group explores methods for filtrating hazardous and otherwise unwanted molecules from drinking water, for example by adsorption in active carbon filters. In this project, the students use graphene as an idealized model for active carbon, and estimate the energy of adsor...

  17. [Magnetoreception systems in birds: a review of current research].

    Science.gov (United States)

    Kishkinev, D A; Chernetsov, N S

    2014-01-01

    Currently at least two independent systems of magnetoreception are believed to exist in birds, based on different biophysical principles, located in different parts of their bodies, and having different innervation. One magnetoreceptory system is located in the retina and may be based on photo-induced biradical chemical reactions on the basis of cryptochrome. Information from these receptors is processed in a specialized part of visual Wulst, the so-called Cluster N. There are good reasons to believe that this visual magnetoreceptor processes compass magnetic information which is necessary for migratory orientation. The second magnetoreceptory system is probably iron-based (biogenic magnetite), is located somewhere in the upper beak (its exact location and ultrastructure of receptors remain unknown), and is innervated by the ophthalmic branch of trigeminal nerve. It cannot be ruled out that this system participates in spatial representation and helps forming either a kind of map or more primitive signposts, based on regular spatial variation of the geomagnetic field. The magnetic map probably governs navigation of migrating birds across hundreds and thousands of kilometers. Apart from these two systems whose existence may be considered to be convincingly shown (even if their details are not yet fully clear), there are data on the existence of magnetoreceptors based on the vestibular system. It cannot be ruled out that iron-based magnetoreception takes place in lagena (a structure homologous to cochlea of marsupials and eutherians), and the information perceived is processes in vestibular nuclei. The very existence of this magnetoreception system needs verification, and its function remains completely open.

  18. Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research

    Science.gov (United States)

    Minori, Karen

    2017-01-01

    Strongyloidiasis is a parasitic neglected disease caused by the nematode Strongyloides stercoralis affecting 30 to 100 million people worldwide. Complications, strongly associated with alcoholism, organ transplants, and HTLV-1 virus, often arise due to late diagnosis, frequently leading to patient death. Lack of preemptive diagnosis is not the only difficulty when dealing with this parasite, since there are no gold standard diagnostic techniques, and the ones used have problems associated with sensitivity, resulting in false negatives. Treatment is also an issue as ivermectin and benzimidazoles administration leads to inconsistent cure rates and several side effects. Researching new anti-Strongyloides drugs is a difficult task since S. stercoralis does not develop until the adult stages in Mus musculus (with the exception of SCID mice), the main experimental host model. Fortunately, alternative parasite models can be used, namely, Strongyloides ratti and S. venezuelensis. However, even with these models, there are other complications in finding new drugs, which are associated with specific in vitro assay protocol steps, such as larvae decontamination. In this review, we highlight the challenges associated with new drug search, the compounds tested, and a list of published in vitro assay methodologies. We also point out advances being made in strongyloidiasis diagnosis so far. PMID:28210503

  19. Microorganisms in metalworking fluids: Current issues in research and management

    Directory of Open Access Journals (Sweden)

    Elżbieta A. Trafny

    2013-02-01

    Full Text Available The microbial contamination of water miscible metalworking fl uids (MWFs is a serious problem in metal industry. A good maintenance of MWF re-circulation systems can extend the lifetime of coolants and ensure the quality of the tools produced. In MWFs, as in the other water-based environments, microorganisms usually live in the form of biofi lms, the communities of bacteria and fungi attached to the surface of sumps, metal parts and also to each other. Biofi lms exhibit very high resistance to biocides. The effect of biocides that are used as additives to MWFs to control the growth of the bacterial and fungal microbiomes (microorganisms characteristic to the individual coolant system have become the subject of research only in recent years. There are also only sparse reports on the impact of biocides on microorganisms growing in biofi lms in MWF installations. Fast growing mycobacteria are important members of these biofi lm communities. Their presence has recently been linked with the occurrence of cases of hypersensitivity pneumonitis, a serious respiratory disorder in the metal industry employees. The new, relatively fast and inexpensive techniques to assess the species diversity within MWF microbiomes and their population size should be developed in order to control the microorganisms’ proliferation in MWFs and to diminish the occupational exposure to harmful bioaerosols in metal industry.

  20. Current practices and research updates on diabetes mellitus in canine

    Directory of Open Access Journals (Sweden)

    Pankaj Kumar

    2014-11-01

    Full Text Available Diabetes has evidence in ancient literatures, though recently is being considered as one amongst the most emerging disease condition in both human and companion animals. Diabetes mellitus is one of the common endocrinopathy of dog characterized by hyperglycemia, glycosuria and weight loss. Reports suggests high fraction of canine population suffer with diabetes world over. Studies in different veterinary hospitals of United States suggest increase in cases of canine diabetes and decrease in case fatality rate over time. Increase in cases of canine diabetes worldwide is attributed to awareness amongst pet owners, better veterinary health facilities, breed preferences by dog owners, increase dependence on commercial feeds, obesity, etc. Diabetes in most dogs is immune mediated and insulin dependent. Breed predisposition in canine is attributed to dog leukocyte antigen gene pool encoding form major histocompatibility complex-II molecules, however research is still underway. Diagnosis of diabetes still relies on blood sugar evaluation for screening of canine population, though many other diagnostic methods have shown promising benefits including measurement of fructosamine and glycated haemoglobin. Management of diabetes in dog is based on insulin therapy, diet modification and exercise. Use of oral anti-diabetics drugs in canine is limited though experimental studies have shown promising results. Alternative therapies have been explored, but only a few approaches have shown promise for clinical application.

  1. Current development of acupuncture research in Parkinson's disease.

    Science.gov (United States)

    Zeng, Bai-Yun; Salvage, Sarah; Jenner, Peter

    2013-01-01

    Parkinson's disease is an age-related progressive neurodegenerative disease. The etiology and pathogenetic mechanisms that cause PD are still not fully understood. The available treatments to PD are only symptomatic relief. Acupuncture is used to treat many medical conditions for 1000 years in China and has gained wider and increasing acceptance within both public and medical profession because it has been a very safe and well-tolerated treatment. In this chapter, we reviewed relevant laboratory findings regarding acupuncture mechanism on Parkinson's. We showed that acupuncture stimulation in Parkinson's models had generated valuable mechanistic insight of Parkinson's and showed that acupuncture treatment is in fact a neuroprotective therapy that increase the release of various neuroprotective agents such as brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and cyclophilin A. In addition, acupuncture therapy slows cell death process and attenuates oxidative stress to dopaminergic neurons in the substantia nigra. Further, acupuncture therapy modulates neuronal activity of the basal ganglia output structures. These results suggest that early application of acupuncture therapy to Parkinson's patients may be helpful for the best efficacy of acupuncture treatment. It is hopeful that translation of achievement in acupuncture research in Parkinson's models will maximize the potentials of acupuncture treatment.

  2. Current Challenges and Prospective Research for Upscaling Hybrid Perovskite Photovoltaics.

    Science.gov (United States)

    Williams, Spencer T; Rajagopal, Adharsh; Chueh, Chu-Chen; Jen, Alex K-Y

    2016-03-01

    Organic-inorganic hybrid perovskite photovoltaics (PSCs) are poised to push toward technology translation, but significant challenges complicating commercialization remain. Though J-V hysteresis and ecotoxicity are uniquely imposing issues at scale, CH3NH3PbI3 degradation is by far the sharpest limitation to the technology's potential market contribution. Herein, we offer a perspective on the practical market potential of PSCs, the nature of fundamental PSC challenges at scale, and an outline of prospective solutions for achieving module scale PSC production tailored to intrinsic advantages of CH3NH3PbI3. Although integrating PSCs into the energy grid is complicated by CH3NH3PbI3 degradation, the ability of PSCs to contribute to consumer electronics and other niche markets like those organic photovoltaics have sought footing in rests primarily upon the technology's price point. Thus, slot die, roll-to-roll processing has the greatest potential to enable PSC scale-up, and herein, we present a perspective on the research necessary to realize fully printable PSCs at scale.

  3. Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research.

    Science.gov (United States)

    Mendes, Tiago; Minori, Karen; Ueta, Marlene; Miguel, Danilo Ciccone; Allegretti, Silmara Marques

    2017-01-01

    Strongyloidiasis is a parasitic neglected disease caused by the nematode Strongyloides stercoralis affecting 30 to 100 million people worldwide. Complications, strongly associated with alcoholism, organ transplants, and HTLV-1 virus, often arise due to late diagnosis, frequently leading to patient death. Lack of preemptive diagnosis is not the only difficulty when dealing with this parasite, since there are no gold standard diagnostic techniques, and the ones used have problems associated with sensitivity, resulting in false negatives. Treatment is also an issue as ivermectin and benzimidazoles administration leads to inconsistent cure rates and several side effects. Researching new anti-Strongyloides drugs is a difficult task since S. stercoralis does not develop until the adult stages in Mus musculus (with the exception of SCID mice), the main experimental host model. Fortunately, alternative parasite models can be used, namely, Strongyloides ratti and S. venezuelensis. However, even with these models, there are other complications in finding new drugs, which are associated with specific in vitro assay protocol steps, such as larvae decontamination. In this review, we highlight the challenges associated with new drug search, the compounds tested, and a list of published in vitro assay methodologies. We also point out advances being made in strongyloidiasis diagnosis so far.

  4. Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research

    Directory of Open Access Journals (Sweden)

    Tiago Mendes

    2017-01-01

    Full Text Available Strongyloidiasis is a parasitic neglected disease caused by the nematode Strongyloides stercoralis affecting 30 to 100 million people worldwide. Complications, strongly associated with alcoholism, organ transplants, and HTLV-1 virus, often arise due to late diagnosis, frequently leading to patient death. Lack of preemptive diagnosis is not the only difficulty when dealing with this parasite, since there are no gold standard diagnostic techniques, and the ones used have problems associated with sensitivity, resulting in false negatives. Treatment is also an issue as ivermectin and benzimidazoles administration leads to inconsistent cure rates and several side effects. Researching new anti-Strongyloides drugs is a difficult task since S. stercoralis does not develop until the adult stages in Mus musculus (with the exception of SCID mice, the main experimental host model. Fortunately, alternative parasite models can be used, namely, Strongyloides ratti and S. venezuelensis. However, even with these models, there are other complications in finding new drugs, which are associated with specific in vitro assay protocol steps, such as larvae decontamination. In this review, we highlight the challenges associated with new drug search, the compounds tested, and a list of published in vitro assay methodologies. We also point out advances being made in strongyloidiasis diagnosis so far.

  5. Ovarian aging and menopause: current theories, hypotheses, and research models.

    Science.gov (United States)

    Wu, Julie M; Zelinski, Mary B; Ingram, Donald K; Ottinger, Mary Ann

    2005-12-01

    Aging of the reproductive system has been studied in numerous vertebrate species. Although there are wide variations in reproductive strategies and hormone cycle components, many of the fundamental changes that occur during aging are similar. Evolutionary hypotheses attempt to explain why menopause occurs, whereas cellular hypotheses attempt to explain how it occurs. It is commonly believed that a disruption in the hypothalamic-pituitary-gonadal axis is responsible for the onset of menopause. Data exist to demonstrate that the first signs of menopause occur at the level of the brain or the ovary. Thus, finding an appropriate and representative animal model is especially important for the advancement of menopause research. In primates, there is a gradual decline in the function of the hypothalamic-pituitary-gonadal (HPG) axis ultimately resulting in irregularities in menstrual cycles and increasingly sporadic incidence of ovulation. Rodents also exhibit a progressive deterioration in HPG axis function; however, they also experience a period of constant estrus accompanied by intermittent ovulations, reduced progesterone levels, and elevated circulating estradiol levels. It is remarkable to observe that females of other classes also demonstrate deterioration in HPG axis function and ovarian failure. Comparisons of aging in various taxa provide insight into fundamental biological mechanisms of aging that could underlie reproductive decline.

  6. Asthma in the Elderly: Current Understanding and Future Research Needs

    Science.gov (United States)

    Hanania, Nicola A.; King, Monroe J.; Braman, Sidney S.; Saltoun, Carol; Wise, Robert A.; Enright, Paul; Falsey, Ann A; Mathur, Sameer K.; Ramsdell, Joe W.; Rogers, Linda; Stempel, David A.; Lima, John J.; Fish, James E.; Wilson, Sandra R.; Boyd, Cynthia; Patel, Kushang V.; Irvin, Charles G.; Yawn, Barbara P.; Halm, Ethan A; Wasserman, Stephen I.; Sands, Mark F.; Ershler, William B.; Ledford, Dennis K.

    2011-01-01

    Asthma in the elderly (AIE) is under diagnosed and under treated and there is a paucity of knowledge. The National Institute on Aging convened this workshop to identify what is known, what gaps in knowledge remain and suggest research directions needed to improve the understanding and care of AIE. Asthma presenting at an advanced age often has similar clinical and physiologic consequences as seen with younger individuals but co-morbid illnesses and the psychosocial effects of aging may affect the diagnosis, clinical presentation and care of asthma in this population. At least two phenotypes exist among elderly asthma; those with long-standing asthma have more severe airflow limitation and less complete reversibility than those with late-onset asthma. Many challenges exist in the recognition and treatment of asthma in the elderly. Furthermore, the pathophysiological mechanisms of AIE are likely to be different from those seen in young asthmatics and these differences may influence the clinical course and outcomes of asthma in this population. PMID:21872730

  7. Current progress in epigenetic research for hepato-carcinomagenesis

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Hepatocellular carcinoma is the main type of primary liver cancer,and also one of the most malignant tumors.At present,the pathogenesis mechanisms of liver cancer are not entirely clear.It has been shown that inactivation of tumor suppressor genes and activation of oncogenes play a significant role in carcinogenesis,caused by the genetic and epigenetic aberrance.In the past,people generally thought that genetic mutation is a key event of tumor pathogenesis,and somatic mutation of tumor suppressor genes is in particular closely associated with oncogenesis.With deeper understanding of tumors in recent years,increasing evidence has shown that epigenetic silencing of those genes,as a result of aberrant hypermethylation of CpG islands in promoters and histone modification,is essential to carcinogenesis and metastasis.The term epigenetics refers to heritable changes in gene expression caused by regulation mechanisms,other than changes in the underlying DNA sequence.Specific epigenetic processes include DNA methylation,genome imprinting,chromotin remodeling,histone modification and microRNA regulations.This paper reviews recent epigenetics research progress in the hepatocellular carcinoma study,and tries to depict the relationships between hepatocellular carcinomagenesis and DNA methylation as well as microRNA regulation.

  8. Current progress in epigenetic research for hepato-carcinomagenesis

    Institute of Scientific and Technical Information of China (English)

    HUANG Jian

    2009-01-01

    Hepatocellular carcinoma is the main type of primary liver cancer, and also one of the most malignant tumors. At present, the pathogenesis mechanisms of liver cancer are not entirely clear. It has been shown that inactivation of tumor suppressor genes and activation of oncogenes play a significant role in carcinogenesis, caused by the genetic and epigenetic aberrance. In the past, people generally thought that genetic mutation is a key event of tumor pathogenesis, and somatic mutation of tumor suppressor genes is in particular closely associated with oncogenesis. With deeper understanding of tumors in recent years, increasing evidence has shown that epigenetic silencing of those genes, as a result of aberrant hypermethylation of CpG islands in promoters and histone modification, is essential to carcinogenesis and metastasis. The term epigenetics refers to heritable changes in gene expression caused by regulation mechanisms, other than changes in the underlying DNA sequence. Specific epi-genetic processes include DNA methylation, genome imprinting, chromotin remodeling, histone modi-fication and microRNA regulations. This paper reviews recent epigenetics research progress in the hepatocellular carcinoma study, and tries to depict the relationships between hepatocellular carci-nomagenesis and DNA methylation as well as microRNA regulation.

  9. Ocean Science for Decision-Making: Current Activities of the National Research Council's Ocean Studies Board

    Science.gov (United States)

    Roberts, S.; Glickson, D.; Mengelt, C.; Forrest, S.; Waddell, K.

    2012-12-01

    The National Research Council is a private, nonprofit organization chartered by Congress in 1916 as an expansion of the U.S. National Academy of Sciences. Its mission is to improve the use of science in government decision making and public policy, increase public understanding, and promote the acquisition and dissemination of knowledge in matters involving science, engineering, technology, and health. Within the National Research Council, the Ocean Studies Board (OSB) mission is to explore the science, policies, and infrastructure needed to understand, manage, and conserve coastal and marine environments and resources. OSB undertakes studies and workshops on emerging scientific and policy issues at the request of federal agencies, Congress, and others; provides program reviews and guidance; and facilitates communication on oceanographic issues among different sectors. OSB also serves as the U.S. National Committee to the international, nongovernmental Scientific Committee on Oceanic Research (SCOR). OSB has produced reports on a wide range of topics of interest to researchers and educators, the federal government, the non-profit sector, and industry. Recent reports have focused on ecosystem services in the Gulf of Mexico after the Deepwater Horizon oil spill, sea level rise on the U.S. west coast, scientific ocean drilling needs and accomplishments, requirements for sustained ocean color measurements, critical infrastructure for ocean research, tsunami warning and preparedness, ocean acidification, and marine and hydrokinetic power resource assessments. Studies that are currently underway include responding to oil spills in the Arctic, evaluating the effectiveness of fishery stock rebuilding plans, and reviewing the National Ocean Acidification Research Plan. OSB plays an important role in helping create policy decisions and disseminating important information regarding various aspects of ocean science.

  10. Soil Contamination and Remediation Strategies. Current research and future challenge

    Science.gov (United States)

    Petruzzelli, G.

    2012-04-01

    eliminating the source of pollution, but also on blocking the pathways from contaminants to receptors or reducing the exposure to contaminants,. Future challenge integration of sustainability into remediation decision-making. Soil is not a waste! There is a growing interest in the clean up approaches that maintain soil quality after remediation treatments. This issue is of great importance in the U.S.A. where the EPA from 2009 is promoting innovative clean-up strategies (Green Remediation). Green remediation is defined as the practice of considering all environmental effects of remedy and incorporating options to maximize environmental benefit of cleanup actions . These remediation strategies restore contaminated sites to productive use with a great attention to the global environmental quality, including the preservation of soil functionality according to the following principles: use minimally invasive technologies; use passive energy technologies such as bioremediation and phytoremediation as primary remedies or finishing steps where possible and effective; minimize soil and habitat disturbance; minimize bioavailability of contaminants trough adequate contaminant source and plume control If we move from the current definition of remedial targets based on total concentrations, technologies with low impact on the environment can be utilized reducing the wrong choice to disposal soil in landfill destroying quickly a not renewable essential resource.

  11. Musings on privacy issues in health research involving disaggregate geographic data about individuals

    Directory of Open Access Journals (Sweden)

    AbdelMalik Philip

    2009-07-01

    Full Text Available Abstract This paper offers a state-of-the-art overview of the intertwined privacy, confidentiality, and security issues that are commonly encountered in health research involving disaggregate geographic data about individuals. Key definitions are provided, along with some examples of actual and potential security and confidentiality breaches and related incidents that captured mainstream media and public interest in recent months and years. The paper then goes on to present a brief survey of the research literature on location privacy/confidentiality concerns and on privacy-preserving solutions in conventional health research and beyond, touching on the emerging privacy issues associated with online consumer geoinformatics and location-based services. The 'missing ring' (in many treatments of the topic of data security is also discussed. Personal information and privacy legislations in two countries, Canada and the UK, are covered, as well as some examples of recent research projects and events about the subject. Select highlights from a June 2009 URISA (Urban and Regional Information Systems Association workshop entitled 'Protecting Privacy and Confidentiality of Geographic Data in Health Research' are then presented. The paper concludes by briefly charting the complexity of the domain and the many challenges associated with it, and proposing a novel, 'one stop shop' case-based reasoning framework to streamline the provision of clear and individualised guidance for the design and approval of new research projects (involving geographical identifiers about individuals, including crisp recommendations on which specific privacy-preserving solutions and approaches would be suitable in each case.

  12. The Current State of Research on Networks in China’s Business System

    NARCIS (Netherlands)

    J. Meuer (Johannes); B. Krug (Barbara)

    2009-01-01

    textabstractThe purpose of the paper is to assess the current state of network research in China’s business system. Research on networks has developed significantly during the last decades in regards to analytic techniques, number of research projects, and accumulated findings. While research on net

  13. The Current State of Research on Networks in China’s Business System

    NARCIS (Netherlands)

    J. Meuer (Johannes); B. Krug (Barbara)

    2009-01-01

    textabstractThe purpose of the paper is to assess the current state of network research in China’s business system. Research on networks has developed significantly during the last decades in regards to analytic techniques, number of research projects, and accumulated findings. While research on net

  14. SERVICE USER INVOLVEMENT IN SOCIAL WORK PRACTICE, EDUCATION AND RESEARCH IN BOSNIA-HERZEGOVINA

    Directory of Open Access Journals (Sweden)

    Sanela Čekić Bašić

    2009-01-01

    Full Text Available Despite the fact that the social work profession is considered to be a profession “promoting ... empowerment and liberation of individuals in order to attain greater level of well-being“, the inclusion of the user perspective is a relatively new and still much debated phenomenon. Having in mind that the involvement of service users as experience experts in social work practice, education and research is a very demanding and complex process, the paper analyses a number of challenges faced by social workers, teachers and researchers in their everyday work due to the requirement of inclusion of the service user perspective. The idea of service user involvement in planning, execution and evaluation of curricular contents is a quite recent one in Bosnia and Herzegovina since the social work education reflects the idea on professionals (social workers, teachers or researchers as ultimate knowledge holders. The author defines two categories of factors obstructing the service user involvement in the education and research process: one is related to education institutions and the other to service users, i.e. their organizations, and discusses necessary prerequisites for stronger connections between institutions (departments of social work, practice and service users.

  15. Reporting of ethical protection in recent oral and maxillofacial surgery research involving human subjects.

    Science.gov (United States)

    Pitak-Arnnop, P; Sader, R; Hervé, C; Dhanuthai, K; Bertrand, J-Ch; Hemprich, A

    2009-07-01

    This retrospective observational study investigated the frequency of reporting ethical approval and informed consent in recently published oral and maxillofacial surgery (OMS) research involving human subjects. All research involving human subjects published in the International Journal of Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, British Journal of Oral and Maxillofacial Surgery, and Journal of Cranio-Maxillofacial Surgery during January to June 2005-2007 were analysed for disclosure of ethical approval by a local ethical committee and obtaining informed consent from the subjects. 534 articles were identified; ethical approval was documented in 118 (22%) and individual patient consent in 135 (25%). 355 reports (67%) did not include a statement on ethical approval or informed consent and only 74 reports (14%) disclosed statements of both. Ethical documentation in retrospective and observational studies was scant; 12% of randomised controlled trials and 38% of non-random trials did not report both of ethical protections. Most recent OMS publications involving humans failed to mention ethical review or subjects' consent. Authors must adhere to the international research ethics guidelines and journal instructions, while editors should play a gatekeeper role to protect research participants, uphold scientific integrity and maintain public trust in the experimental process and OMS profession.

  16. Faculty beliefs, perceptions, and level of community involvement in their research: a survey at one urban academic institution.

    Science.gov (United States)

    Goldberg-Freeman, Clara; Kass, Nancy; Gielen, Andrea; Tracey, Patricia; Bates-Hopkins, Barbara; Farfel, Mark

    2010-12-01

    Health researchers are increasingly interested in how best to engage communities in their health-related research studies. To help determine how researchers have interacted with community members in their research, we conducted a survey of full-time faculty from the Johns Hopkins Medical Institutions regarding researchers' beliefs and experiences with community-based research. Approximately 41% of respondents who conducted human subject studies had enrolled local residents in their research. Researchers whose studies were based in the surrounding community were significantly more likely to involve community members in all stages of their research (e.g., selection of the problem, project planning, data collection, interpretation and dissemination of results, or developing an intervention) than were faculty whose studies enrolled community members as research participants but whose studies were not set in the community. Over 90% of all faculty respondents agree that community involvement improves the relevance of their research, although almost 60% had not done so. Most faculty value community involvement, but they want more institutional support for such activities and they seek better skills to involve community. Few studies have surveyed researchers who enroll community members as research participants to document practices regarding community involvement in the research process. Given that the majority (73.6%) of faculty responded that they intend to include local residents in their upcoming studies, future research to evaluate interventions designed to facilitate community involvement, especially in the inner city, would help stakeholders identify best practices for involving and engaging communities in health research.

  17. Current research and future directions in pattern identification: Results of an international symposium.

    Science.gov (United States)

    Lee, Myeong Soo; Lee, Ju Ah; Alraek, Terje; Bian, Zhao-Xiang; Birch, Stephen; Goto, Hirozo; Jung, Jeeyoun; Kao, Shung-Te; Moon, Sang-Kwan; Park, Bongki; Park, Kyung-Mo; You, Sooseong; Yun, Kyung-Jin; Zaslawski, Chris

    2016-12-01

    A symposium on pattern identification (PI) was held at the Korea Institute of Oriental Medicine (KIOM) on October 2, 2013, in Daejeon, South Korea. This symposium was convened to provide information on the current research in PI as well as suggest future research directions. The participants discussed the nature of PI, possible research questions, strategies and future international collaborations in pattern research. With eight presentations and an extensive panel discussion, the symposium allowed participants to discuss research methods in traditional medicine for PI. One speaker presented the topic, 'Clinical pattern differentiation and contemporary research in PI.' Two speakers presented current trends in research on blood stasis while the remaining five other delegates discussed the research methods and future directions of PI research. The participants engaged in in-depth discussions regarding the nature of PI, potential research questions, strategies and future international collaborations in pattern research.

  18. Reflections of a team approach to involving people with dementia in research.

    Science.gov (United States)

    King, Amanda; Hopkinson, Jane; Milton, Rebecca

    2016-01-01

    The article reflects on the ways in which a person-centred approach was used to ensure that people with dementia were given an opportunity to participate in research. The authors discuss three key issues-the importance of including people with dementia in research, informed consent and the possibility of accidental disclosure of diagnosis. The study was an in-depth examination of the ways in which the cancer team manages patients with memory problems and patients with dementia, and the experiences of these patients and their families in accessing outpatient cancer treatment and care in Wales. The study findings will be reported elsewhere. This article aims to add to the small body of existing knowledge within the literature that describes the experiences of researchers in actively involving people with dementia in research.

  19. Action research methodology in clinical pharmacy: how to involve and change.

    Science.gov (United States)

    Nørgaard, Lotte Stig; Sørensen, Ellen Westh

    2016-06-01

    Introduction The focus in clinical pharmacy practice is and has for the last 30-35 years been on changing the role of pharmacy staff into service orientation and patient counselling. One way of doing this is by involving staff in change process and as a researcher to take part in the change process by establishing partnerships with staff. On the background of the authors' widespread action research (AR)-based experiences, recommendations and comments for how to conduct an AR-study is described, and one of their AR-based studies illustrate the methodology and the research methods used. Methodology AR is defined as an approach to research which is based on a problem-solving relationship between researchers and clients, which aims at both solving a problem and at collaboratively generating new knowledge. Research questions relevant in AR-studies are: what was the working process in this change oriented study? What learning and/or changes took place? What challenges/pitfalls had to be overcome? What were the influence/consequences for the involved parts? When to use If you want to implement new services and want to involve staff and others in the process, an AR methodology is very suitable. The basic advantages of doing AR-based studies are grounded in their participatory and democratic basis and their starting point in problems experienced in practice. Limitations Some of the limitations in AR-studies are that neither of the participants in a project steering group are the only ones to decide. Furthermore, the collective process makes the decision-making procedures relatively complex.

  20. Involving mental health service users in suicide-related research: a qualitative inquiry model.

    Science.gov (United States)

    Lees, David; Procter, Nicholas; Fassett, Denise; Handley, Christine

    2016-03-01

    To describe the research model developed and successfully deployed as part of a multi-method qualitative study investigating suicidal service-users' experiences of mental health nursing care. Quality mental health care is essential to limiting the occurrence and burden of suicide, however there is a lack of relevant research informing practice in this context. Research utilising first-person accounts of suicidality is of particular importance to expanding the existing evidence base. However, conducting ethical research to support this imperative is challenging. The model discussed here illustrates specific and more generally applicable principles for qualitative research regarding sensitive topics and involving potentially vulnerable service-users. Researching into mental health service users with first-person experience of suicidality requires stakeholder and institutional support, researcher competency, and participant recruitment, consent, confidentiality, support and protection. Research with service users into their experiences of sensitive issues such as suicidality can result in rich and valuable data, and may also provide positive experiences of collaboration and inclusivity. If challenges are not met, objectification and marginalisation of service-users may be reinforced, and limitations in the evidence base and service provision may be perpetuated.

  1. Payment of research participants: current practice and policies of Irish research ethics committees.

    LENUS (Irish Health Repository)

    Roche, Eric

    2013-09-01

    Payment of research participants helps to increase recruitment for research studies, but can pose ethical dilemmas. Research ethics committees (RECs) have a centrally important role in guiding this practice, but standardisation of the ethical approval process in Ireland is lacking.

  2. Current and Future Research in Active Control of Lightweight, Flexible Structures Using the X-56 Aircraft

    Science.gov (United States)

    Ryan, John J.; Bosworth, John T.; Burken, John J.; Suh, Peter M.

    2014-01-01

    The X-56 Multi-Utility Technology Testbed aircraft system is a versatile experimental research flight platform. The system was primarily designed to investigate active control of lightweight flexible structures, but is reconfigurable and capable of hosting a wide breadth of research. Current research includes flight experimentation of a Lockheed Martin designed active control flutter suppression system. Future research plans continue experimentation with alternative control systems, explore the use of novel sensor systems, and experiments with the use of novel control effectors. This paper describes the aircraft system, current research efforts designed around the system, and future planned research efforts that will be hosted on the aircraft system.

  3. Parental Involvement and Home Environment in Music: Current and Former Students from Selected Community Music Programs in Brazil and the United States

    Science.gov (United States)

    Barnes, Gail V.; DeFreitas, Aureo; Grego, John

    2016-01-01

    The purpose of this study was to determine whether individuals' perceptions of parental involvement and home environment in music vary with nationality (Brazil/United States) and time frame (past/current). Past and current students from selected community music programs in the United States and Brazil completed the PI-HEM (Parental Involvement and…

  4. Book Review: Current Issues in International Human Resource Management and Strategy Research

    DEFF Research Database (Denmark)

    Gretzinger, Susanne

    2009-01-01

    The article reviews the book "Current Issues in International Human Resource Management and Strategy Research," edited by Marion Festing and Susanne Royer.......The article reviews the book "Current Issues in International Human Resource Management and Strategy Research," edited by Marion Festing and Susanne Royer....

  5. Book Review: Current Issues in International Human Resource Management and Strategy Research

    DEFF Research Database (Denmark)

    Gretzinger, Susanne

    2009-01-01

    The article reviews the book "Current Issues in International Human Resource Management and Strategy Research," edited by Marion Festing and Susanne Royer.......The article reviews the book "Current Issues in International Human Resource Management and Strategy Research," edited by Marion Festing and Susanne Royer....

  6. A Sustainable Model for Integrating Current Topics in Machine Learning Research into the Undergraduate Curriculum

    Science.gov (United States)

    Georgiopoulos, M.; DeMara, R. F.; Gonzalez, A. J.; Wu, A. S.; Mollaghasemi, M.; Gelenbe, E.; Kysilka, M.; Secretan, J.; Sharma, C. A.; Alnsour, A. J.

    2009-01-01

    This paper presents an integrated research and teaching model that has resulted from an NSF-funded effort to introduce results of current Machine Learning research into the engineering and computer science curriculum at the University of Central Florida (UCF). While in-depth exposure to current topics in Machine Learning has traditionally occurred…

  7. A Sustainable Model for Integrating Current Topics in Machine Learning Research into the Undergraduate Curriculum

    Science.gov (United States)

    Georgiopoulos, M.; DeMara, R. F.; Gonzalez, A. J.; Wu, A. S.; Mollaghasemi, M.; Gelenbe, E.; Kysilka, M.; Secretan, J.; Sharma, C. A.; Alnsour, A. J.

    2009-01-01

    This paper presents an integrated research and teaching model that has resulted from an NSF-funded effort to introduce results of current Machine Learning research into the engineering and computer science curriculum at the University of Central Florida (UCF). While in-depth exposure to current topics in Machine Learning has traditionally occurred…

  8. Current, Short Term, Future and Star Wars Research Projects for Ornamental Crops

    Science.gov (United States)

    The USDA-ARS Greenhouse Production Research Group is involved in fundamental and developmental plant research aimed at developing tools for early stress detection and efficient agrochemical utilization for protected horticulture crops. The group conducts basic plant biology research with the goal o...

  9. Public involvement in health priority setting: future challenges for policy, research and society.

    Science.gov (United States)

    Hunter, David James; Kieslich, Katharina; Littlejohns, Peter; Staniszewska, Sophie; Tumilty, Emma; Weale, Albert; Williams, Iestyn

    2016-08-15

    Purpose - The purpose of this paper is to reflect on the findings of this special issue and discusses the future challenges for policy, research and society. The findings suggest that challenges emerge as a result of legitimacy deficits of both consensus and contestatory modes of public involvement in health priority setting. Design/methodology/approach - The paper draws on the discussions and findings presented in this special issue. It seeks to bring the country experiences and case studies together to draw conclusions for policy, research and society. Findings - At least two recurring themes emerge. An underlying theme is the importance, but also the challenge, of establishing legitimacy in health priority setting. The country experiences suggest that we understand very little about the conditions under which representative, or authentic, participation generates legitimacy and under which it will be regarded as insufficient. A second observation is that public participation takes a variety of forms that depend on the opportunity structures in a given national context. Given this variety the conceptualization of public participation needs to be expanded to account for the many forms of public participation. Originality/value - The paper concludes that the challenges of public involvement are closely linked to the question of how legitimate processes and decisions can be generated in priority setting. This suggests that future research must focus more narrowly on conditions under which legitimacy are generated in order to expand the understanding of public involvement in health prioritization.

  10. Current Research.

    Science.gov (United States)

    Hunt, Mary Alice

    1981-01-01

    Describes a doctoral dissertation entitled "World-Future Images in Childrens Literature" which analyzed books on science fiction or utopian fiction by 43 authors of children's literature to determine whether presentations were optimistic or pessimistic. Results indicating generally optimistic stories are discussed, as well as strengths and…

  11. Teaching Earth Sciences as an interdisciplinary subject: Novel module design involving research literature

    Science.gov (United States)

    Tong, Vincent C. H.

    2010-05-01

    The study of Earth Sciences requires an interdisciplinary approach as it involves understanding scientific knowledge originating from a wide spectrum of research areas. Not only does it include subjects ranging from, for instance, hydrogeology to deep crustal seismology and from climate science to oceanography, but it also has many direct applications in closely related disciplines such as environmental engineering and natural resources management. While research crossing traditional disciplinary boundaries in geosciences is becoming increasingly common, there is only limited integration of interdisciplinary research in the teaching of the subject. Given that the transition from undergraduate education based on subject modules to postgraduate interdisciplinary research is never easy, such integration is a highly desirable pedagogical approach at both undergraduate and postgraduate levels. My presentation is based on a recent teaching project involving novel design of an undergraduate course. The course is implemented in order to address the synergy between research and teaching (Tong, 2009). This project has been shown to be effective and successful in teaching geosciences undergraduates at the University of London. The module consists of studying core geophysical principles and linking them directly to a selection of recently published research papers in a wide range of interdisciplinary applications. Research reviewing and reporting techniques are systematically developed, practised and fully integrated into teaching of the core scientific theories. A fully-aligned assignment with a feedback website invites the students to reflect on the scientific knowledge and the study skills related to research literature they have acquired in the course. This teaching project has been recognized by a teaching award (http://www.clpd.bbk.ac.uk/staff/BETA). In this presentation, I will discuss how undergraduate teaching with a focus on research literature in Earth Sciences can

  12. Technical support to the Solvent Refined Coal (SRC) demonstration projects: assessment of current research and development

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, M.S.; Rodgers, B.R.; Brown, C.H.; Carlson, P.K.; Gambill, W.R.; Gilliam, T.M.; Holmes, J.M.; Krishnan, R.P.; Parsly, L.F.

    1980-12-01

    A program to demonstrate Solvent Refined Coal (SRC) technology has been initiated by the US Department of Energy (DOE) in partnership with two industrial groups. Project management responsibility has been assigned to the Oak Ridge Operations Office (ORO) of DOE. ORO requested that the Oak Ridge National Laboratory assess current research and development (R and D) activities and develop recommendations for those activities that might contribute to successful completion of the SRC demonstration plant projects. The objectives of this final report are to discuss in detail the problem areas in SRC; to discuss the current and planned R and D investigations relevant to the problems identified; and to suggest appropriate R and D activities in support of designs for the SRC demonstration plants. Four types of R and D activities are suggested: continuation of present and planned activities; coordination of activities and results, present and proposed; extension/redirection of activities not involving major equipment purchase or modifications; and new activities. Important examples of the first type of activity include continuation of fired heater, slurry rheology, and slurry mixing studies at Ft. Lewis. Among the second type of activity, coordination of data acquisition and interpretation is recommended in the areas of heat transfer, vapor/liquid equilibria, and physical properties. Principal examples of recommendations for extension/redirection include screening studies at laboratory scale on the use of carbonaceous precoat (e.g., anthracite) infiltration, and 15- to 30-day continuous tests of the Texaco gasifier at the Texaco Montebello facility (using SRC residues).

  13. Reviewing current knowledge in snatch performance and technique: the need for future directions in applied research.

    Science.gov (United States)

    Ho, Lester K W; Lorenzen, Christian; Wilson, Cameron J; Saunders, John E; Williams, Morgan D

    2014-02-01

    This is a review of current research trends in weightlifting literature relating to the understanding of technique and its role in successful snatch performance. Reference to the world records in the snatch from the 1960s onwards indicates little progress across all weight categories. With such mediocre advances in performance at the International level, there is a need to better understand how snatch technique can improve performance even if only by a small margin. Methods of data acquisition for technical analysis of the snatch have involved mostly 2-dimensional barbell and joint kinematics. Although key variables which play a role in the successful outcome of a snatch lift have been heavily investigated, few studies have combined variables relating both the barbell and the weightlifter in their analyses. This suggests the need for a more detailed approach integrating both barbell-related and weightlifter-related data to enhance understanding of the mechanics of a successful lift. Currently, with the aid of technical advances in motion analysis, data acquisition, and methods of analysis, a more accurate representation of the movement can be provided. Better ways of understanding the key characteristics of technique in the snatch could provide the opportunity for more effective individualized feedback from the coach to the athlete, which should in turn lead to improved performance in competition.

  14. 40 CFR 26.1110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Science.gov (United States)

    2010-07-01

    ... kinds of research involving no more than minimal risk, and for minor changes in approved research. 26... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving Intentional Exposure of Non-pregnant, Non-nursing Adults § 26.1110 Expedited review procedures for...

  15. Computational intelligence in gait research: a perspective on current applications and future challenges.

    Science.gov (United States)

    Lai, Daniel T H; Begg, Rezaul K; Palaniswami, Marimuthu

    2009-09-01

    Our mobility is an important daily requirement so much so that any disruption to it severely degrades our perceived quality of life. Studies in gait and human movement sciences, therefore, play a significant role in maintaining the well-being of our mobility. Current gait analysis involves numerous interdependent gait parameters that are difficult to adequately interpret due to the large volume of recorded data and lengthy assessment times in gait laboratories. A proposed solution to these problems is computational intelligence (CI), which is an emerging paradigm in biomedical engineering most notably in pathology detection and prosthesis design. The integration of CI technology in gait systems facilitates studies in disorders caused by lower limb defects, cerebral disorders, and aging effects by learning data relationships through a combination of signal processing and machine learning techniques. Learning paradigms, such as supervised learning, unsupervised learning, and fuzzy and evolutionary algorithms, provide advanced modeling capabilities for biomechanical systems that in the past have relied heavily on statistical analysis. CI offers the ability to investigate nonlinear data relationships, enhance data interpretation, design more efficient diagnostic methods, and extrapolate model functionality. These are envisioned to result in more cost-effective, efficient, and easy-to-use systems, which would address global shortages in medical personnel and rising medical costs. This paper surveys current signal processing and CI methodologies followed by gait applications ranging from normal gait studies and disorder detection to artificial gait simulation. We review recent systems focusing on the existing challenges and issues involved in making them successful. We also examine new research in sensor technologies for gait that could be combined with these intelligent systems to develop more effective healthcare solutions.

  16. Finding a voice: participatory research with street-involved youth in the youth injection prevention project.

    Science.gov (United States)

    Coser, Larissa Rodrigues; Tozer, Kira; Van Borek, Natasha; Tzemis, Despina; Taylor, Darlene; Saewyc, Elizabeth; Buxton, Jane A

    2014-09-01

    This article uses a Positive Youth Development framework to explore the experiences of six experiential youth coresearchers (YCs) in the Youth Injection Prevention (YIP) participatory research project, and the parallel track process of empowerment and capacity building that developed. The YIP project was conducted in Metro Vancouver at the BC Centre for Disease Control and community organizations serving street-involved youth. A process evaluation was conducted to explore themes in the YCs experience in the project, as well as process strengths and challenges. Semistructured interviews with the YCs, researcher field notes, and team meeting and debrief session minutes were analyzed. The YIP project appears to have exerted a positive influence on the YCs. Positive self-identities, sense of purpose, reconceptualization of intellectual ability, new knowledge and skills, supportive relationships, finding a voice, and social and self-awareness were among the positive impacts. Process strengths included team-building activities, team check-in and checkout sessions, and professional networking opportunities. Process challenges included the time required to help YCs overcome personal barriers to participation. The YIP project demonstrates that participatory research with street-involved youth is a viable research option that contributes to positive youth development and empowerment.

  17. Structural dynamics of microsystems—current state of research and future directions

    Science.gov (United States)

    Lin, R. M.; Wang, W. J.

    2006-07-01

    Microsystems or micro-electro-mechanical systems (MEMS), as a newly emerged revolutionary enabling technology, has brought both opportunities and challenges to the field of structural dynamics in a different scale, owing primarily to its interdisciplinary nature of research and extremely small feature size. This paper seeks to present a comprehensive yet critical review on some of the major issues that need to be tackled in the successful realisation of microsystems, with an ultimate objective of further developing and improving the current design capabilities of these systems. The electro-mechanical coupling of typical MEMS devices is first defined and introduced, followed by an in-depth review of the various existing modeling and simulation techniques. Special requirements are discussed when typical MEMS devices need to be tested and existing vibration testing techniques are reviewed. Of particular interest to MEMS devices, structural damping has become a major issue affecting dynamic performance due to the various energy dissipation mechanisms involved. These damping mechanisms have been examined, together with methods developed to model them. Finally, conclusions are made on what have been achieved to date and future prospects of structural dynamics of Microsystems are identified with an intention to stimulate further concerted research in this important emerging area.

  18. [Monogenic obesity - current status of molecular genetic research and clinical importance].

    Science.gov (United States)

    Aldhoon-Hainerová, Irena; Včelák, Josef; Zamrazilová, Hana

    2014-01-01

    Obesity and its comorbidities represent one of the major health problems worldwide. A positive energy balance due to inappropriate life-style changes plays a key role in the current obesity epidemic. The influence of genetic factors is also significant - several studies concluded that genes contribute to the development of obesity by 40-70%. Genetic variability predisposes an individual to tendency or resistance to increase body weight in obesogenic environment. Polygenic type of inheritance is responsible in most of obese individuals. However, an intensive research of the past 20 years has led to an identification of several genes causing monogenic forms of obesity. To date, several monogenic genes (leptin, leptin receptor, prohormon convertase 1, proopiomelanocortin, melanocortin 4 receptor, single-minded homolog 1, brain-derived neurotrophic factor, neurotrophic tyrosine kinase receptor type 2) that are either involved in the neuronal differentiation of the paraventricular nucleus or in the leptin-melanocortin pathway are known to cause obesity. Mutation carriers apart from severe early onset obesity manifest with additional phenotypic characteristics as adrenal insufficiency, impaired immunity and impaired fertility. This review provides an overview of molecular-genetic and clinical research in the field of monogenic obesities including therapeutical approaches.

  19. Crash data quality for road safety research: Current state and future directions.

    Science.gov (United States)

    Imprialou, Marianna; Quddus, Mohammed

    2017-03-02

    Crash databases are one of the primary data sources for road safety research. Therefore, their quality is fundamental for the accuracy of crash analyses and, consequently the design of effective countermeasures. Although crash data often suffer from correctness and completeness issues, these are rarely discussed or addressed in crash analyses. Crash reports aim to answer the five "W" questions (i.e. When?, Where?, What?, Who? and Why?) of each crash by including a range of attributes. This paper reviews current literature on the state of crash data quality for each of these questions separately. The most serious data quality issues appear to be: inaccuracies in crash location and time, difficulties in data linkage (e.g. with traffic data) due to inconsistencies in databases, severity misclassification, inaccuracies and incompleteness of involved users' demographics and inaccurate identification of crash contributory factors. It is shown that the extent and the severity of data quality issues are not equal between attributes and the level of impact in road safety analyses is not yet entirely known. This paper highlights areas that require further research and provides some suggestions for the development of intelligent crash reporting systems.

  20. CITIZENS INVOLVEMENT IN PUBLIC DECISIONS: BETWEEN NORMATIVE FRAMEWORK AND ACTUAL FINDINGS (II - RESEARCH RESULTS

    Directory of Open Access Journals (Sweden)

    Kolozsi Lucia

    2015-07-01

    Full Text Available Local communities’ needs must be addressed by an effective, loyal and transparent action of local institutions in the direction of ensuring participation of the citizens in undertaking decisions concerning that particular community. It is therefore necessary a good communication with the citizens of the local public institutions, and a proper and adequate information of citizens. After presenting in our previous research the main theoretical contributions in the theory of participatory democracy in local governance institutions, but also some practical considerations, including results and restrictions concerning how they are actually implemented in the Romanian public institutions, this paper focuses on presenting and analysing the results of our own researches. We present the results of the research carried out during 2014 on investigationg relevant concerning the public governance in local administration, and particularly in this paper how local administration facilitates the involvement of citizens in decision-making process and their participation in debating the main community issues.

  1. What Researchers Should Know and be Able to do When Contemplating Involvement in Education and Outreach

    Science.gov (United States)

    Ridky, R. W.

    2004-12-01

    At some point in their careers, many researchers are motivated to share what they have learned with a wider audience. As their studies mature, and national awareness for more effective integration of research and education intensifies, researchers are increasingly directing efforts toward informal and pre-college educational sectors. Each initiative comes with good intentions, but many fall short of intended benefit. Quality education and outreach programs develop from the same precepts that shape research programs of high professional standing. A researcher is most likely to make useful contributions when they are willing and able to implement familiar research principles to broader educational endeavors. As with research endeavors, principles of significance, literacy, design, feasibility, analysis and dissemination need to be regarded as essential indicators of education program quality. It is helpful to provide researchers who are contemplating more active educational involvement with more than casual understanding of the purposes underlying their pending contributions. Such understanding is premised on the tenet that education and research are always in the public service and therefore inextricably bound at all levels. Both research and education have, as their ultimate goal, enhanced scientific literacy of the citizenry. By example, it can be shown that the best-supported programs, within government and academia, recognize that the way they translate knowledge and make it available to scientific organizations and the public is critical to their intrinsic societal value and level of support. As education conjures up a host of operational meanings arising from one's own values and experiences, the knowledge researchers bring to pre-college and informal educational settings is often based on personal experience rather than on education research, practice and policy. Researchers may believe that because they spent 13 years in school, an additional 4 years at a

  2. Current Practice in Measuring the Quality of Conceptual Models:Challenges and Research%Current Practice in Measuring the Quality of Conceptual Models:Challenges and Research

    Institute of Scientific and Technical Information of China (English)

    LIU Lei; WU Yu-feng; LI Xiao-jun

    2012-01-01

    How to measure the quality of conceptual models is an important issue in the IS field and related research. This paper conducts a review of research in measuring conceptual model quality and identifies the major theoretical and practical issues that need to be addressed in future studies. We review current classification frameworks for conceptual model quality and practice of measuring conceptual model quality. Based on the review, challenges for studies of measuring the quality of conceptual models are proposed and these challenges are also research points which should be strengthened in future studies.

  3. Involvement of consumers in studies run by the Medical Research Council Clinical Trials Unit: Results of a survey

    Directory of Open Access Journals (Sweden)

    Vale Claire L

    2012-01-01

    Full Text Available Abstract Background We aimed to establish levels of consumer involvement in randomised controlled trials (RCTs, meta-analyses and other studies carried out by the UK Medical Research Council (MRC Clinical Trials Unit across the range of research programs, predominantly in cancer and HIV. Methods Staff responsible for studies that were included in a Unit Progress Report (MRC CTU, April 2009 were asked to complete a semi-structured questionnaire survey regarding consumer involvement. This was defined as active involvement of consumers as partners in the research process and not as subjects of that research. The electronic questionnaires combined open and closed questions, intended to capture quantitative and qualitative information on whether studies had involved consumers; types of activities undertaken; recruitment and support; advantages and disadvantages of involvement and its perceived impact on aspects of the research. Results Between October 2009 and April 2010, 138 completed questionnaires (86% were returned. Studies had been conducted over a 20 year period from 1989, and around half were in cancer; 30% in HIV and 20% were in other disease areas including arthritis, tuberculosis and blood transfusion medicine. Forty-three studies (31% had some consumer involvement, most commonly as members of trial management groups (TMG [88%]. A number of positive impacts on both the research and the researcher were identified. Researchers generally felt involvement was worthwhile and some felt that consumer involvement had improved the credibility of the research. Benefits in design and quality, trial recruitment, dissemination and decision making were also perceived. Researchers felt they learned from consumer involvement, albeit that there were some barriers. Conclusions Whilst most researchers identified benefits of involving consumers, most of studies included in the survey had no involvement. Information from this survey will inform the development

  4. Navigation Hydraulics Research Program: Evaluation of Nanjing Hydraulic Research Institute Physical Model Current Meter.

    Science.gov (United States)

    1990-07-01

    readout circuit CURRENT VELOCITY / DIRECTION SENSOR A mini-servomotor and a piece of fibre optic rod are installed at the base. The rod is turned by...34Description. of The Fibre - Optic Type Miniature Propetler Velocity Meter" for detal Is) THE OPERATION OF THE COMBINED CURRENT VELOCITY ’ DIRECTION METER 1. Plug...of The Fibre - Optic Type Miniature propeller Velocity Meter" for details. Front Panel: Ma /jj (tPj ) Current Direction Readout (Degree) Sensitivity

  5. Service user involvement in giving mental health students feedback on placement: A participatory action research study.

    Science.gov (United States)

    Speers, Janey; Lathlean, Judith

    2015-09-01

    Although the drive to engage service users in service delivery, research and education has mainstream acceptance, it is not easy to achieve meaningful involvement. The contribution that could potentially be made by users whilst accessing services is often overlooked. This study involved stakeholders (mentors, service users and a lecturer) working together to design, evaluate and refine a system enabling students to seek feedback from service users. The feedback concerned mental health students' interpersonal skills and occurred whilst on practice placement. This research aimed to explore the experiences of those concerned when nine students attempted to learn from rather than about service users. A 2-year study, encompassing five cycles of participatory action research (PAR). A small island community in the British Isles, adopting UK standards for pre-registration nurse education. Data came from interviews with service users and mentors and a series of reflective group discussions with students who volunteered to try out the feedback mechanism. The deliberations of the PAR stakeholder group informed the research cycles and added to the data, which were subject to thematic analysis. Findings indicated that service users volunteering to give feedback had unanimously positive experiences. Students' experience lay on a continuum: those with a stronger sense of self were more willing and able to ask for feedback than less confident students. Cultural adjustment to the role change needed was challenging, requiring self-awareness and courage. Over time, all students achieved deep learning and, for some, learning appeared transformative. Although contextual, the study concluded that the feedback initiative encouraged the development of more equitable relationships, in which mental health nurses respected the expertise of service users. This potentially benefits student development, recovery-orientated practice, service users and HEIs searching for meaningful ways to

  6. Principles and indicators of successful consumer involvement in NHS research: results of a Delphi study and subgroup analysis.

    Science.gov (United States)

    Boote, Jonathan; Barber, Rosemary; Cooper, Cindy

    2006-02-01

    Consumer involvement in NHS research is Department of Health policy within the UK. Despite the existence of policy directives and guidance, until recently there has been no consensus among consumers and researchers about what it means to involve consumers successfully in NHS research. This paper discusses the value of consensus research in this policy area, and presents the detailed findings of a Delphi study carried out to reach consensus on principles and indicators of successful consumer involvement in NHS research. Study participants, comprising consumers, researchers and consumer-researchers, were identified using a purposive sampling strategy. Consensus was reached on eight clear and valid principles of successful consumer involvement in NHS research, with each principle having at least one clear and valid indicator. Subgroup analysis revealed few significant differences in how consumers, researchers and consumer-researchers rated the principles and indicators. The implications and limitations of the study are discussed. Further research is needed to assess: (1) the usefulness of the principles and indicators for differing models of consumer involvement, health research methodologies, and subject areas within health research; and (2) the impact of 'successful' consumer involvement on health research processes and outcomes.

  7. Novel participatory methods of involving patients in research: naming and branding a longitudinal cohort study, BRIGHTLIGHT.

    Science.gov (United States)

    Taylor, Rachel M; Mohain, Jasjeet; Gibson, Faith; Solanki, Anita; Whelan, Jeremy; Fern, Lorna A

    2015-03-14

    Patient and public involvement (PPI) is central to research and service planning. Identifying effective, meaningful ways of involvement is challenging. The cohort study 'Do specialist services for teenagers and young adults with cancer add value?' follows young people for three years, examining outcomes associated with specialist care. Participant retention in longitudinal research can be problematic potentially jeopardising study completion. Maximising study awareness through high impact branding and publicity may improve study retention. Study names are typically generated by researchers rather than designed with patients. We aimed to involve young people in developing a brand identity and name to 'Do specialist services for teenagers and young adults with cancer add value?'. Nine young people aged 17-26 years diagnosed with cancer when aged 14-25 years participated in a one day workshop with further data collection at a patient conference. Methodology was similar to conventional branding and naming exercises and was divided into six stages. The workshop comprised five stages. Stage 1: 'What's in a brand' allowed young people to enquire why brands/logos are important, Stage 2: 'Brand Transformation' identified what young people needed to know and believe about the study when approached about participation, Stage 3: 'Brand Essence' determined how we wanted the study to be perceived by young people, Stage 4: 'What's in a name' identified potential names for the study. Stage 5: 'Logo creation' assembled the mood and feel of logos. Stage 6 was logo design and an electronic survey of 249 young people attending a patient conference. BRIGHTLIGHT was the final study name and the brand essence (or study personality) was friendly, supportive and inspiring. Four logos were designed and the final logo received 47% (n = 115) of votes. Acceptance and retention to BRIGHTLIGHT is higher than anticipated (80% versus 60%), this may be related to our integral PPI strategy. We

  8. Involving high school students in computational physics university research: Theory calculations of toluene adsorbed on graphene

    CERN Document Server

    Ericsson, Jonas; Mathiesen, Christoffer; Sepahvand, Benjamin; Borck, Øyvind; Gunnarsson, Linda; Lydmark, Pär; Schröder, Elsebeth

    2016-01-01

    To increase public awareness of theoretical materials physics, a small group of high school students is invited to participate actively in a current research projects at Chalmers University of Technology. The Chalmers research group explores methods for filtrating hazardous and otherwise unwanted molecules from drinking water, for example by adsorption in active carbon filters. In this project, the students use graphene as an idealized model for active carbon, and estimate the energy of adsorption of the methylbenzene toluene on graphene with the help of the atomic-scale calculational method density functional theory. In this process the students develop an insight into applied quantum physics, a topic usually not taught at this educational level, and gain some experience with a couple of state-of-the-art calculational tools in materials research.

  9. Involving High School Students in Computational Physics University Research: Theory Calculations of Toluene Adsorbed on Graphene.

    Science.gov (United States)

    Ericsson, Jonas; Husmark, Teodor; Mathiesen, Christoffer; Sepahvand, Benjamin; Borck, Øyvind; Gunnarsson, Linda; Lydmark, Pär; Schröder, Elsebeth

    2016-01-01

    To increase public awareness of theoretical materials physics, a small group of high school students is invited to participate actively in a current research projects at Chalmers University of Technology. The Chalmers research group explores methods for filtrating hazardous and otherwise unwanted molecules from drinking water, for example by adsorption in active carbon filters. In this project, the students use graphene as an idealized model for active carbon, and estimate the energy of adsorption of the methylbenzene toluene on graphene with the help of the atomic-scale calculational method density functional theory. In this process the students develop an insight into applied quantum physics, a topic usually not taught at this educational level, and gain some experience with a couple of state-of-the-art calculational tools in materials research.

  10. Involving High School Students in Computational Physics University Research: Theory Calculations of Toluene Adsorbed on Graphene

    Science.gov (United States)

    Borck, Øyvind; Gunnarsson, Linda; Lydmark, Pär

    2016-01-01

    To increase public awareness of theoretical materials physics, a small group of high school students is invited to participate actively in a current research projects at Chalmers University of Technology. The Chalmers research group explores methods for filtrating hazardous and otherwise unwanted molecules from drinking water, for example by adsorption in active carbon filters. In this project, the students use graphene as an idealized model for active carbon, and estimate the energy of adsorption of the methylbenzene toluene on graphene with the help of the atomic-scale calculational method density functional theory. In this process the students develop an insight into applied quantum physics, a topic usually not taught at this educational level, and gain some experience with a couple of state-of-the-art calculational tools in materials research. PMID:27505418

  11. Managing Ethical Problems in Qualitative Research Involving Vulnerable Populations, Using a Pilot Study

    Directory of Open Access Journals (Sweden)

    Evalina van Wijk RN, PhD

    2013-02-01

    Full Text Available The purpose of the researcher's study was to examine the meaning that intimate partners of female rape victims attached to their lived experiences after the rape. The conduct of qualitative research concerning non-offending partners of female rape victims, however, often involves multifaceted ethical and practical challenges, which can be managed through the use of pilot studies. The pilot study described in this report had three objectives. The first was to pretest and refine the proposed method for locating, accessing, and recruiting intimate partners of female rape victims, within the first two weeks after the rape, for participation in a six-month longitudinal study. The second objective was to identify and prevent all possible risk factors in the proposed recruitment and data collection methods that could harm the participants' safety during the main study. The third objective was to determine the feasibility of the main study, in terms of the limited financial and human resources available. The pilot phase was valuable in identifying ethical and methodological problems during the recruitment of participants and collection of data. It allowed for methodological adjustments prior to the main study and confirmed the feasibility of the overall research design. A pilot, pretesting phase is therefore seen as an essential component of a qualitative study involving a vulnerable population.

  12. Librarian involvement in a nutrition undergraduate research course: preparing nutrition students for evidence-based practice.

    Science.gov (United States)

    Smith, Susan C; Penumetcha, Meera

    2010-01-01

    Given the foundational importance of literature searching skills to later stages of research and, ultimately, evidence-based practice, the authors wanted to assess a unique strategy for teaching such skills. This pilot study describes the results of an undergraduate nutrition research course in which a librarian lead several class sessions. The goal of this study was to assess students' perceptions, attitudes and use of research literature and resources before and after a course partially taught by a librarian. Twenty-seven students enrolled in an undergraduate Introduction to Research course at Georgia State University were given pre- and post-test questionnaires at the beginning and end of a course that included three librarian-led class sessions. Most of the results indicate that the repeated involvement of a librarian enriched this particular undergraduate research course. By the end of the course, students were more comfortable in libraries and with using library resources; they used the campus library more frequently; they were more confident in their ability to find high-quality information on nutrition-related topics and identify strengths and weaknesses of different information sources; and they felt they gained skills that will help them achieve their educational and career goals.

  13. From (Un)Willingness to InvolveMENt: Development of a Successful Study Brand for Recruitment of Diverse MSM to a Longitudinal HIV Research.

    Science.gov (United States)

    Frew, Paula M; Williams, Victoria A; Shapiro, Eve T; Sanchez, Travis; Rosenberg, Eli S; Fenimore, Vincent L; Sullivan, Patrick S

    2013-11-21

    HIV continues to be a major concern among MSM, yet Black MSM have not been enrolled in HIV research studies in proportionate numbers to White MSM. We developed an HIV prevention research brand strategy for MSM. Questionnaires and focus groups were conducted with 54 participants. Descriptive statistics and chi-square analyses were performed and qualitative data were transcribed and content analyzed to identify common themes. Formative research results indicated that younger Black MSM (18-29 years) were less likely to think about joining prevention studies compared to older (≥30 years) Black MSM (x(2) = 5.92, P = 0.015). Qualitative and quantitative results indicate four prominent themes related to brand development: (1) communication sources (message deliverer), (2) message (impact of public health messaging on perceptions of HIV research), (3) intended audience (underlying issues that influence personal relevance of HIV research), and (4) communication channels (reaching intended audiences). The findings highlight the importance of behavioral communication translational research to effectively engage hard-to-reach populations. Despite reservations, MSM in our formative study expressed a need for active involvement and greater education to facilitate their engagement in HIV prevention research. Thus, the brand concept of "InvolveMENt" emerged.

  14. Biomedical research involving patients with disorders of consciousness: ethical and legal dimensions

    Directory of Open Access Journals (Sweden)

    Michele Farisco

    2014-09-01

    Full Text Available The directive 2001/20/UE and the research involving patients with docs. Research involving patients with disorders of consciousness (DOCs deserves special ethical and legal attention because of its Janus-faced nature. On the one hand, it raises concerns about the risk to expose the involved subjects to disproportionate risks not respecting their individual dignity, particularly their right to be cared for; on the other hand, research is an essential tool in order to improve the clinical condition of patients with DOCs. The present paper concerns the ethical and legal dimensions of biomedical research involving patients with disorders of consciousness. In particular, it focuses on informed consent to experimental treatments, which is a challenging issue both from an ethical and legal point of view. The first part reads the Directive 2001/20/EU in the light of the experimentation of patients with DOCs, and suggests a revision in order to better assess the issue of informed consent. The particular case of informed consent for observational studies of non-communicative patients. The second part presents an informed consent form for studies through video-recording of patients unable to communicate their own consent. This form has been elaborated by the bioethics unit of the project "Review of the nosography of vegetative states: application of methods of behavioral analysis to individuals in coma or vegetative state" developed at the Italian National Institute of Health. Relevance of the suggested form. The paper describes the conceptual framework of the form for informed consent to studies through video-recoding, which is a relevant example of what issues should be included in an informed consent for any type of studies through video-recording of patients unable to express their own consent. The article has been sent on November the 7th 2013, before the adoption of the Regulation (EU no. 536/2014 (and consequent abrogation of the Directive 2001

  15. Biomedical research involving patients with disorders of consciousness: ethical and legal dimensions.

    Science.gov (United States)

    Farisco, Michele; Evers, Kathinka; Petrini, Carlo

    2014-01-01

    THE DIRECTIVE 2001/20/UE AND THE RESEARCH INVOLVING PATIENTS WITH DOCS: Research involving patients with disorders of consciousness (DOCs) deserves special ethical and legal attention because of its Janus-faced nature. On the one hand, it raises concerns about the risk to expose the involved subjects to disproportionate risks not respecting their individual dignity, particularly their right to be cared for; on the other hand, research is an essential tool in order to improve the clinical condition of patients with DOCs. The present paper concerns the ethical and legal dimensions of biomedical research involving patients with disorders of consciousness. In particular, it focuses on informed consent to experimental treatments, which is a challenging issue both from an ethical and legal point of view. The first part reads the Directive 2001/20/EU in the light of the experimentation of patients with DOCs, and suggests a revision in order to better assess the issue of informed consent. THE PARTICULAR CASE OF INFORMED CONSENT FOR OBSERVATIONAL STUDIES OF NON-COMMUNICATIVE PATIENTS: The second part presents an informed consent form for studies through video-recording of patients unable to communicate their own consent. This form has been elaborated by the bioethics unit of the project "Review of the nosography of vegetative states: application of methods of behavioral analysis to individuals in coma or vegetative state" developed at the Italian National Institute of Health. RELEVANCE OF THE SUGGESTED FORM: The paper describes the conceptual framework of the form for informed consent to studies through video-recoding, which is a relevant example of what issues should be included in an informed consent for any type of studies through video-recording of patients unable to express their own consent. The article has been sent on November the 7th 2013, before the adoption of the Regulation (EU) no. 536/2014 (and consequent abrogation of the Directive 2001/20/EU) and the release

  16. Space Weather Monitoring for the IHY: Involving Students Worldwide in the Research Process

    Science.gov (United States)

    Scherrer, D.; Burress, B.; Ross, K.

    2008-06-01

    Our project explores how new methods of space weather data collection and networks of instruments can lead to innovative and exciting ways of involving audiences in the research process. We describe our space weather monitors, being distributed to high school students and universities worldwide for the International Heliophysical Year. The project includes a centralized data collection site, accessible to anyone with or without a monitor. Classroom materials, developed in conjunction with the Chabot Space & Science Center in California, are designed to introduce teachers and students to the Sun, space weather, the Earth's ionosphere, and how to use monitor data to encourage students to undertake "hands-on" research and gain experience with real scientific data. For more information, see \\url{http://sid-stanford.edu}.

  17. Current Methods in Health Behavior Research Among U.S. Community College Students: A Review of the Literature.

    Science.gov (United States)

    Pokhrel, Pallav; Little, Melissa A; Herzog, Thaddeus A

    2014-06-01

    The majority of health behavior research involving college students in the United States has focused on 4-year college students. Two-year or community college students have been less studied, although a significant proportion of U.S. undergraduates, primarily those from disadvantaged socioeconomic and/or racial/ethnic background, are enrolled in community colleges. Thus, there is a need to enhance health behavior and health promotion research among community college students. This study systematically reviewed 42 published, peer-reviewed health behavior studies conducted among U.S. community college students in order to determine the current state of research in the area with regard to behaviors studied, research designs used, recruitment and data collection strategies practiced, rates of student participation, and characteristics of the participants represented. Findings identified the methodological limitations of current research and suggested optimal recruitment and data collection methods suitable for various research needs. Findings are discussed in the context of enhancing health behavior research among U.S. community college students.

  18. Illuminating the Dark Side of the Internet with Actor-Network Theory: An Integrative Review of Current Cybercrime Research

    Directory of Open Access Journals (Sweden)

    Rocci Luppicini

    2014-06-01

    Full Text Available Cybercrime is a relatively new area of research within criminology and media studies. The purpose of this paper is to pull together current research scholarship at the intersection of Actor-Network Theory (ANT and cybercrime by addressing the following question: How does ANT apply to cybercrime research? A selective integrative review of cybercrime research utilizing ANT was conducted to examine recent developments and identify trends. The review draws on core research papers that span 2002 to 2013. Findings provided a strong indication of ANT’s role in key areas of current cybercrime, namely, cyber bullying, cyber theft, and cyber terrorism and cyber espionage. More specifically, ANT was applied within cyber criminology research to address complex problems involving human-technological interactions, advance alternative models and theoretical perspectives, compare ANT with existing models and theoretical perspectives, and leverage understanding of network influences on actors. Recommendations are provided to help optimize the application of ANT to cybercrime research and practice. This paper helps advance knowledge at the intersection of ANT and the study of cyber criminology.

  19. 45 CFR 46.406 - Research involving greater than minimal risk and no prospect of direct benefit to individual...

    Science.gov (United States)

    2010-10-01

    ... no prospect of direct benefit to individual subjects, but likely to yield generalizable knowledge... Involved as Subjects in Research § 46.406 Research involving greater than minimal risk and no prospect of... to children is presented by an intervention or procedure that does not hold out the prospect...

  20. ETHICS IN CLINICAL RESEARCH: IS ETHICS INVOLVED INTO THE PHARMACY STUDIES IN EUROPE?

    Directory of Open Access Journals (Sweden)

    Viera Žufková

    2013-06-01

    Full Text Available One of the key questions in medicine nowadays is the ethics and its maximum involvement into medical profession. The absence of ethics is very notable in public and professional relations. In spite of the fact that the pharmacy profession was separated from the medical profession in the 13th century by the emperor Frederic II, the ethics is involved into pharmacy study in minimum amount.  In the article there is presented the ethics inclusion into pharmacy study in 31 Universities of the European Union (EU. The method of our research was the analysis of 31 WebPages of Faculties of Pharmacy in the EU. The ethics is taught in the 45% study programmes. It is mostly a part of syllabus of master programme (Czech Republic, Estonia and Portugal or bachelor programme (Slovakia. We have not managed to find a full study plan in 13% of study plans. As the ethics remains the crucial part of the pharmacy profession, there is a great importance of its involvement into the pharmacy study. The Code of Conduct for Pharmacy students with its seven principles shall be a part of ethical preparation of future pharmacists in Europe. 

  1. S'COOL Provides Research Opportunities and Current Data for Today's Technological Classroom

    Science.gov (United States)

    Green, Carolyn J.; Chambers, Lin H.; Racel, Anne M.

    1999-01-01

    NASA's Students' Cloud Observations On-Line (S'COOL) project, a hands-on educational project, was an innovative idea conceived by the scientists in the Radiation Sciences Branch at NASA Langley Research Center, Hampton, Virginia, in 1996. It came about after a local teacher expressed the idea that she wanted her students to be involved in real-life science. S'COOL supports NASA's Clouds and the Earth's Radiant Energy System (CERES) instrument, which was launched on the Tropical Rainforest Measuring Mission (TRMM) in November, 1997, as part of NASA's Earth Science Enterprise. With the S'COOL project students observe clouds and related weather conditions, compute data and note vital information while obtaining ground truth observations for the CERES instrument. The observations can then be used to help validate the CERES measurements, particularly detection of clear sky from space. In addition to meeting math, science and geography standards, students are engaged in using the computer to obtain, report and analyze current data, thus bringing modern technology into the realm of classroom, a paradigm that demands our attention.

  2. On the concept of e-maintenance: Review and current research

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Alexandre [Nancy Research Centre for Automatic Control (CRAN), UMR 7039 CNRS-UHP, INPL, 2, rue Jean Lamour, 54519 Vandoeuvre-les-Nancy Cedex (France); Crespo Marquez, Adolfo [Department of Industrial Management, School of Engineering, University of Seville, Camino de los Descubrimientos, s/n. 41092 Sevilla (Spain)], E-mail: adolfo.crespo@esi.us.es; Iung, Benoit [Nancy Research Centre for Automatic Control (CRAN), UMR 7039 CNRS-UHP, INPL, 2, rue Jean Lamour, 54519 Vandoeuvre-les-Nancy Cedex (France)

    2008-08-15

    The importance of the maintenance function has increased because of its role in keeping and improving system availability and safety, as well as product quality. To support this role, the development of the communication and information technologies has allowed the emergence of the concept of e-maintenance. Within the era of e-manufacturing and e-business, e-maintenance provides the opportunity for a new maintenance generation. As we will discuss later in this paper, e-maintenance integrates existing telemaintenance principles, with Web services and modern e-collaboration principles. Collaboration allows to share and exchange not only information but also knowledge and (e)-intelligence. By means of a collaborative environment, pertinent knowledge and intelligence become available and usable at the right place and time, in order to facilitate reaching the best maintenance decisions. This paper outlines the basic ideas within the e-maintenance concept and then provides an overview of the current research and challenges in this emerging field. An underlying objective is to identify the industrial/academic actors involved in the technological, organizational or management issues related to the development of e-maintenance. Today, this heterogeneous community has to be federated in order to bring up e-maintenance as a new scientific discipline.

  3. A Review of Research on Metacognition in Science Education: Current and Future Directions

    Science.gov (United States)

    Zohar, Anat; Barzilai, Sarit

    2013-01-01

    The goal of this study is to map the current state of research in the field of metacognition in science education, to identify key trends, and to discern areas and questions for future research. We conducted a systematic analysis of 178 studies published in peer-reviewed journals in the years 2000-2012 and indexed in the ERIC database. The…

  4. Research of resisting of the biological active point for constant and alternative current

    Directory of Open Access Journals (Sweden)

    S. N. Peregudov

    2008-05-01

    Full Text Available Is conducted research of resistance of biologically active point (BAT on a direct and variable current. Research results are presented. The estimation of intercommunication between resistance of skin and by an electromagnetic radiation in BAT is done. Is shown possibility of the use of experimental information for diagnostics of the state of human to the organism.

  5. Mindfulness for Children in Public Schools: Current Research and Developmental Issues to Consider

    Science.gov (United States)

    Chadwick, Jeanne; Gelbar, Nicholas W.

    2016-01-01

    Mindfulness-based interventions have increased in popularity over the past decade and interest continues to increase in the potential to use mindfulness-based interventions in schools. The current research concerning school-based mindfulness-based interventions is reviewed in this article. This research base is fragmented, as most of the studies…

  6. A Review of Research on Metacognition in Science Education: Current and Future Directions

    Science.gov (United States)

    Zohar, Anat; Barzilai, Sarit

    2013-01-01

    The goal of this study is to map the current state of research in the field of metacognition in science education, to identify key trends, and to discern areas and questions for future research. We conducted a systematic analysis of 178 studies published in peer-reviewed journals in the years 2000-2012 and indexed in the ERIC database. The…

  7. Current research trends and perspectives on materials-based hydrogen storage solutions: A critical review

    CSIR Research Space (South Africa)

    Ren, Jianwei

    2016-01-01

    Full Text Available Effective hydrogen storage solutions have been pursued for decades, and materials-based hydrogen storage is a research frontier of much current interest. Yet, no researched materials to date have come close to the DOE 2020 targets for hydrogen...

  8. The Focus of Current HCI Research in Usability Evaluation and Feedback

    DEFF Research Database (Denmark)

    Høegh, Rune Thaarup

    2007-01-01

    This paper presents the findings from a systematic literature study of the research on usability evaluation and feedback. The literature study covers the papers published from five key human-computer interaction journals for a period of four years, and depicts the most current research within...

  9. From (UnWillingness to InvolveMENt: Development of a Successful Study Brand for Recruitment of Diverse MSM to a Longitudinal HIV Research

    Directory of Open Access Journals (Sweden)

    Paula M. Frew

    2013-01-01

    Full Text Available Background. HIV continues to be a major concern among MSM, yet Black MSM have not been enrolled in HIV research studies in proportionate numbers to White MSM. We developed an HIV prevention research brand strategy for MSM. Methods. Questionnaires and focus groups were conducted with 54 participants. Descriptive statistics and chi-square analyses were performed and qualitative data were transcribed and content analyzed to identify common themes. Results. Formative research results indicated that younger Black MSM (18–29 years were less likely to think about joining prevention studies compared to older (≥30 years Black MSM (x2=5.92, P=0.015. Qualitative and quantitative results indicate four prominent themes related to brand development: (1 communication sources (message deliverer, (2 message (impact of public health messaging on perceptions of HIV research, (3 intended audience (underlying issues that influence personal relevance of HIV research, and (4 communication channels (reaching intended audiences. Conclusion. The findings highlight the importance of behavioral communication translational research to effectively engage hard-to-reach populations. Despite reservations, MSM in our formative study expressed a need for active involvement and greater education to facilitate their engagement in HIV prevention research. Thus, the brand concept of “InvolveMENt” emerged.

  10. Involving Scientists in Outreach: Incentives, Barriers, and Recommendations from Research Findings

    Science.gov (United States)

    Melton, G.; Laursen, S.; Andrews, E.; Weaver, A.; Hanley, D.; Shamatha, J. H.

    2004-12-01

    Public agencies that fund scientific research are increasingly requiring that researchers invest some of their funding in education or outreach activities that have a "broader impact." Yet barriers exist that inhibit scientists' motivation to participate in K-12 outreach. We will share findings from a quantitative and qualitative study that examined the motivations, rewards, and obstacles for scientists who participate in outreach. We found that most researchers became interested in doing outreach out of a desire to contribute and an expectation of having fun and enjoying the experience. They typically gave outreach presentations away from work, acted as a resource for school teachers, or helped with teacher professional development. However, scientists viewed outreach as a form of volunteer work that was auxiliary to their other responsibilities. Thus, time constraints, a lack of information about outreach opportunities, and the lower value placed on outreach by departments constituted significant barriers to their participation. Scientists involved in outreach typically found their efforts to be rewarding, but occasionally factors left a negative impression, such as poor audience response, classroom management difficulties, organizational problems, or demonstrations not going as planned. Based upon our findings, we offer recommendations on how scientists' participation and experiences in K-12 outreach can be improved, including how to successfully recruit scientists, create a positive outreach experience, and increase institutional support for outreach work.

  11. Current Research Activities in Drive System Technology in Support of the NASA Rotorcraft Program

    Science.gov (United States)

    Handschuh, Robert F.; Zakrajsek, James J.

    2006-01-01

    Drive system technology is a key area for improving rotorcraft performance, noise/vibration reduction, and reducing operational and manufacturing costs. An overview of current research areas that support the NASA Rotorcraft Program will be provided. Work in drive system technology is mainly focused within three research areas: advanced components, thermal behavior/emergency lubrication system operation, and diagnostics/prognostics (also known as Health and Usage Monitoring Systems (HUMS)). Current research activities in each of these activities will be presented. Also, an overview of the conceptual drive system requirements and possible arrangements for the Heavy Lift Rotorcraft program will be reviewed.

  12. [Resource activation in clinical psychology and psychotherapy: review of theoretical issues and current research].

    Science.gov (United States)

    Groß, L J; Stemmler, M; de Zwaan, M

    2012-08-01

    This review summarises theoretical issues and current research on working with clients' resources and strengths in clinical psychology and psychotherapy. Resource activation is considered as an important common factor in psychotherapy. In general, resource activation means an explicit focus on resources, strengths and potentials of the clients. After defining the term resources, considerations with regard to therapeutic attitude, principles of resource activation, approaches to resource diagnostics and different research strategies are presented. Current research focuses especially on the relation between resource activation and process variables in out-patient treatment.

  13. INSTITUTIONALISM AND INFORMATION SYSTEMS: CURRENT STATE OF THE ART AND POSITION OF FRENCH RESEARCH

    Directory of Open Access Journals (Sweden)

    Rolande Marciniak

    2009-10-01

    Full Text Available The various currents of institutionalism are used in management science, particularly in the area of information systems. Richard Scott's global model is a fertile framework for the analysis of institutional research. First, we will study the contributions of French research to institutionalism. Then, returning to the fundamentals of information systems (IS, we will show that the interaction between institutions and IS can be analysed via the notion of formal and informal rules. Research carried out at the University of Paris

  14. Reducing Health Disparities and Enhancing the Responsible Conduct of Research Involving LGBT Youth.

    Science.gov (United States)

    Fisher, Celia B; Mustanski, Brian

    2014-09-01

    Although there is clearly a need for evidenced-based behavioral or biomedical prevention or treatment programs for suicide, substance abuse, and sexual health targeted to members of the LGBT population under the age of eighteen, few such programs exist, due in substantial part to limited research knowledge. Ambiguities in regulations that govern human subjects protections and the related inconsistencies in institutional review board (IRB) interpretations of regulatory language are the key reason for the lack of rigorous clinical trial evidence to support treatment choices and prevention approaches to reducing health disparities for this population. Given the socially sensitive nature of suicide, substance abuse, and HIV and STI research in general and LGBT research specifically, in the absence of empirical data to guide their decisions, IRBs must often rely on subjective judgments of minimal risk, which can lead to overestimation of the magnitude and probability of psychological, social, and informational harms that might arise from LGBT youth participation in clinical trials. In addition, more than other youth, LGBT adolescents whose families are unaware of their sexual orientation or gender identity or whose families have victimized them on account of it may be reluctant to participate in studies that require guardian permission. This, in turn, intensifies problems of recruitment and unbiased sampling. However, many IRBs are reluctant to apply federal regulations permitting waiver of guardian permission under conditions in which such permission is clearly not "feasible" or "reasonable" to require. Consequently, many investigators have excluded LGBT individuals under eighteen years of age in health intervention research proposals because of anticipated or actual difficulties obtaining IRB approval. This situation is in conflict with current ethical discourse focusing on the right of youths to participate in trials that will protect them from receiving

  15. Reprioritizing current research trends in medical education: a reflection on research activities in Saudi Arabia.

    Science.gov (United States)

    Obeidat, Akef S; Alhaqwi, Ali Ibrahim; Abdulghani, Hamza Mohammad

    2015-04-01

    There are numerous national efforts to determine and develop research priorities of medical education in Saudi Arabia. These priorities were first proposed in 2010 by "Dr Al-Khuli's Chair for Developing Medical Education in Saudi Arabia". The proposed priority domains were: curriculum, students, faculty, and quality assurance and accreditation. To investigate publications in medical education at the national and international levels in areas relating to these proposed priorities. Electronic search within PubMed database for papers relating to each domain of priority was conducted at national and international levels in the last three years, using the same keywords as the priority domains, but only confined to undergraduate medical education. Out of 3145 articles retrieved when searching with keyword as broad as "undergraduate medical curriculum" only 81 articles worldwide and 3 articles from Saudi Arabia were dealing with curriculum related issues as a whole. Further search on the sub-domains "effective strategies to manage undergraduate curriculum" and "undergraduate medical education models", resulted in the retrieval of few articles worldwide and none from Saudi Arabia. At the national level, there were 63 publications from Saudi Arabia that were either course (topic)-specific or could not be classified under the four domains specified by Dr Al-Khuli's Chair. Research activities in medical education in Saudi Arabia in the last 3 years showed diversity and lack of focus in the research priorities. Efforts of academic and research centers should continue to monitor and encourage these activities toward achieving the recommended priorities.

  16. Current and Planned Cochlear Implant Research at New York University Laboratory for Translational Auditory Research

    Science.gov (United States)

    Svirsky, Mario A.; Fitzgerald, Matthew B.; Neuman, Arlene; Sagi, Elad; Tan, Chin-Tuan; Ketten, Darlene; Martin, Brett

    2013-01-01

    The Laboratory of Translational Auditory Research (LTAR/NYUSM) is part of the Department of Otolaryngology at the New York University School of Medicine and has close ties to the New York University Cochlear Implant Center. LTAR investigators have expertise in multiple related disciplines including speech and hearing science, audiology, engineering, and physiology. The lines of research in the laboratory deal mostly with speech perception by hearing impaired listeners, and particularly those who use cochlear implants (CIs) or hearing aids (HAs). Although the laboratory's research interests are diverse, there are common threads that permeate and tie all of its work. In particular, a strong interest in translational research underlies even the most basic studies carried out in the laboratory. Another important element is the development of engineering and computational tools, which range from mathematical models of speech perception to software and hardware that bypass clinical speech processors and stimulate cochlear implants directly, to novel ways of analyzing clinical outcomes data. If the appropriate tool to conduct an important experiment does not exist, we may work to develop it, either in house or in collaboration with academic or industrial partners. Another notable characteristic of the laboratory is its interdisciplinary nature where, for example, an audiologistandan engineer might work closely to develop an approach that would not have been feasible if each had worked singly on the project. Similarly, investigators with expertise in hearing aids and cochlear implants might join forces to study how human listeners integrate information provided by a CI and a HA. The following pages provide a flavor of the diversity and the commonalities of our research interests. PMID:22668763

  17. Midwifery and dialogue in organizations. Emergent, mutual involvement in action research

    DEFF Research Database (Denmark)

    Kristiansen, Marianne; Bloch-Poulsen, Jørgen

    the process. That goes for the understanding of dialogue as sharing, daring and caring; for dialogic competencies as, e.g., confirmation and meta-communication; and for generatively facilitated conversations as midwifery. The methodology is accordingly characterized as emergent, mutual involvement. The book...... is a dialogue between theory and praxis, too. It integrates research, action, and training as well as theories of interpersonal and organizational communication, Roger's humanistic psychology, Gadamer's philosophical hermeneutics, and Buber's philosophy of dialogue. The empirical material consists...... of approximately 50 colleague supervision or midwifery conversations and group-feedback sessions; and of 24 staff appraisal interviews or development conversations, which we followed on a monitor in an adjoining room. After each of these conversations, a feedback session was held. In the book you will find...

  18. Patient involvement in a scientific advisory process: setting the research agenda for medical products.

    Science.gov (United States)

    Elberse, Janneke Elisabeth; Pittens, Carina Anna Cornelia Maria; de Cock Buning, Tjard; Broerse, Jacqueline Elisabeth Willy

    2012-10-01

    Patient involvement in scientific advisory processes could lead to more societally relevant advice. This article describes a case study wherein the Health Council of the Netherlands involved patient groups in an advisory process with a predefined focus: setting a research agenda for medical products development. A four-phase approach was developed to stimulate needs-articulation concerning future medical products for a broad range of patient groups covering 15 disease domains. 119 (expert) patients and 92 non-patient representatives were consulted using interviews and focus groups. In a facilitated way, patients appeared capable and willing to provide input useful for an advisory process. A broad range of medical products was defined serving different purposes. This study showed two dilemmas: first, finding a balance between a predefined focus and being sufficiently broad to enable patients and patient representatives to contribute, and second, finding a balance between relevance for many patients groups and saturation of data for a lower number of patient groups. By taking the context of patients' daily life as starting point patient groups provided new insights. The predefined focus was sometimes perceived as constraining. The GR considered the articulated needs constructive and incorporated patients' input in their advice to the Minister of Health.

  19. 'Take small steps to go a long way' consumer involvement in research into complementary and alternative therapies.

    Science.gov (United States)

    Paterson, Charlotte

    2004-08-01

    This investigation set out to learn about consumer involvement in complementary medicine research from those who have experience of practice in this area. A literature search was combined with written and oral responses from key people and organisations in the UK. Letter or e-mail contact was made with 59 key people and organisations and 43 people responded. Eighteen respondents were interviewed. The overall level of consumer involvement was low but participants provided examples of experiences of consumer involvement in commissioning, designing, carrying out, and disseminating research. Clear roles and tasks and a consumer-friendly research environment, enabled consumers to contribute, gain confidence, and gradually widen their areas of involvement. There appears to be no single 'right way' for researchers and consumers to work together, but with experience and mutual respect researchers became increasingly enthusiastic about the value of the consumer perspective. As one consumer said: 'You have to take small steps to go a long way'.

  20. Research on Digital Output Verification Technology of Electronic DC Current Transformer

    Science.gov (United States)

    Chen, Yuanjie; Wang, Bin; Hu, Haoliang; Xiong, Qianzhu; Yang, Chunyan

    2017-05-01

    Aiming at the error of calibration system when conducting field calibration by electronic DC current transformer’s digital calibration system, an electronic DC current transformer’s digital calibration system based on protocol conversion is proposed and researched. Data frames outputted from merging unit are collected and converted by the system, the digital synchronization is realized by using the synchronous clock device to trigger the second pulse, and it is verified by the virtual instrument design software. The field calibration is conducted to some converter station digital dc current transformer under the rated current of 500A by using the calibration system. By calibrating and analyzing errors, the error is less than 0.075% when tested current is more than 40% of the rated current. According the standard in literature[1], performance of the calibration system is perfect, measured results perfectly meet the requirements of design, and the calibration system has great practical application value.

  1. Fracture detection and mapping for geothermal reservoir definition: an assessment of current technology, research, and research needs

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, N.E.

    1984-11-01

    The detection and mapping of fractures and other zones of high permeability, whether natural or manmade, has been a subject of considerable economic and scientific interest to the pertroleum industry and to the geothermal community. Research related to fractured geothermal reservoirs has been conducted under several past DOE geothermal energy development programs. In this paper we review the present state of technology in fracture detection and mapping. We outline the major problems and limitations of the ''conventional'' techniques, and current research in new technologies. We also present research needs.

  2. An Official American Thoracic Society Research Statement : Current Challenges Facing Research and Therapeutic Advances in Airway Remodeling

    NARCIS (Netherlands)

    Prakash, Y S; Halayko, Andrew J; Gosens, Reinoud; Panettieri Jr., Reynold A; Camoretti-Mercado, Blanca; Penn, Raymond B; Burgess, Janette K

    2017-01-01

    BACKGROUND: Airway remodeling (AR) is a prominent feature of asthma and other obstructive lung diseases that is minimally affected by current treatments. The goals of this Official American Thoracic Society (ATS) Research Statement are to discuss the scientific, technological, economic, and

  3. An Official American Thoracic Society Research Statement : Current Challenges Facing Research and Therapeutic Advances in Airway Remodeling

    NARCIS (Netherlands)

    Prakash, Y S; Halayko, Andrew J; Gosens, Reinoud; Panettieri Jr., Reynold A; Camoretti-Mercado, Blanca; Penn, Raymond B; Burgess, Janette K

    2017-01-01

    BACKGROUND: Airway remodeling (AR) is a prominent feature of asthma and other obstructive lung diseases that is minimally affected by current treatments. The goals of this Official American Thoracic Society (ATS) Research Statement are to discuss the scientific, technological, economic, and regulato

  4. Applying Earlier Literacy Research in Iran to Current Literacy Theory and Policy

    Directory of Open Access Journals (Sweden)

    Brian Street

    2013-05-01

    Full Text Available In this paper, I attempt to bring together approaches toliteracy in theory and in practice, drawing upon variousactivities I have been involved in over the years–research inIranian villages during the 1970s; linking research andtheory to literacy policy, with particular reference to acontribution to the Unesco Global Monitoring Report in2004 and involvement in an ongoing adult literacy trainingprogramme appropriately entitled Learning Empowermentthrough Training in Ethnographic Research (LETTER.IJSCL is interested in publishing original research andreview articles on the relationship between society, culture,and language and in particular ‘linking sound theoreticalapproaches on these fields with visible practical applicationsthat can be used by specialists in anthropology, sociology,linguistics, education, intercultural studies, and policymaking’. I hope that this piece on literacy, with duereference to work in Iran, will fit with that brief.

  5. Data standards for clinical research data collection forms: current status and challenges.

    Science.gov (United States)

    Richesson, Rachel L; Nadkarni, Prakash

    2011-05-01

    Case report forms (CRFs) are used for structured-data collection in clinical research studies. Existing CRF-related standards encompass structural features of forms and data items, content standards, and specifications for using terminologies. This paper reviews existing standards and discusses their current limitations. Because clinical research is highly protocol-specific, forms-development processes are more easily standardized than is CRF content. Tools that support retrieval and reuse of existing items will enable standards adoption in clinical research applications. Such tools will depend upon formal relationships between items and terminological standards. Future standards adoption will depend upon standardized approaches for bridging generic structural standards and domain-specific content standards. Clinical research informatics can help define tools requirements in terms of workflow support for research activities, reconcile the perspectives of varied clinical research stakeholders, and coordinate standards efforts toward interoperability across healthcare and research data collection.

  6. Improving the use of research evidence in guideline development: 10. Integrating values and consumer involvement

    Directory of Open Access Journals (Sweden)

    Oxman Andrew D

    2006-12-01

    should also be explicit. If differences in values are likely to affect a decision, such that people in different setting would likely make different choices about interventions or actions based on differences in their values, global recommendations should be explicit in terms of which values were applied and allow for adaptation after incorporating local values. How should WHO ensure that appropriate values are integrated in recommendations? • All WHO guideline groups should uniformly apply explicit, transparent and clearly described methods for integrating values. • WHO should consider involving relevant stakeholders if this is feasible and efficient. • WHO should develop a checklist for guidelines panels to help them to ensure that ethical considerations relevant to recommendations are addressed explicitly and transparently. How should users and consumers be involved in generating recommendations? • Including consumers in groups that are making global recommendations presents major challenges with respect to the impossibility of including a representative spectrum of consumers from a variety of cultures and settings. Nonetheless, consideration should be given to including consumers in groups who are able to challenge assumptions that are made about the values used for making recommendations, rather than represent the values of consumers around the world. • WHO should establish a network to facilitate involvement of users. • Draft recommendations should be reviewed by consumers, who should be asked explicitly to consider the values that were used. How should values be presented in recommendations? • Recommendations should include a description of how decisions were made about the relative importance of the consequences (benefits, harms and costs of a decision. • Values that influence recommendations should be reported along with the research evidence underlying recommendations. • When differences in values would lead to different decisions or there is

  7. Ethics education in research involving human beings in undergraduate medicine curriculum in Brazil.

    Science.gov (United States)

    Novaes, Maria Rita Garbi; Guilhem, Dirce; Barragan, Elena; Mennin, Stewart

    2013-12-01

    The Brazilian national curriculum guidelines for undergraduate medicine courses inspired and influenced the groundwork for knowledge acquisition, skills development and the perception of ethical values in the context of professional conduct. The evaluation of ethics education in research involving human beings in undergraduate medicine curriculum in Brazil, both in courses with active learning processes and in those with traditional lecture learning methodologies. Curricula and teaching projects of 175 Brazilian medical schools were analyzed using a retrospective historical and descriptive exploratory cohort study. Thirty one medical schools were excluded from the study because of incomplete information or a refusal to participate. Active research for information from institutional sites and documents was guided by terms based on 69 DeCS/MeSH descriptors. Curriculum information was correlated with educational models of learning such as active learning methodologies, tutorial discussions with integrated curriculum into core modules, and traditional lecture learning methodologies for large classes organized by disciplines and reviewed by occurrence frequency of ethical themes and average hourly load per semester. Ninety-five medical schools used traditional learning methodologies. The ten most frequent ethical themes were: 1--ethics in research (26); 2--ethical procedures and advanced technology (46); 3--ethic-professional conduct (413). Over 80% of schools using active learning methodologies had between 50 and 100 hours of scheduled curriculum time devoted to ethical themes whereas more than 60% of traditional learning methodology schools devoted less than 50 hours in curriculum time to ethical themes. The data indicates that medical schools that employ more active learning methodologies provide more attention and time to ethical themes than schools with traditional discipline-based methodologies. Given the importance of ethical issues in contemporary medical

  8. Research on Measurement of Bed Shear Stress Under WaveCurrent Interaction

    Institute of Scientific and Technical Information of China (English)

    徐华; 夏云峰; 张世钊马炳和; 郝思禹; 杜德军

    2015-01-01

    The movement of sediment in estuary and on coast is directly restricted by the bed shear stress. Therefore, the research on the basic problem of sediment movement by the bed shear stress is an important way to research the theory of sediment movement. However, there is not a measuring and computing method to measure the bed shear stress under a complicated dynamic effect like wave and current. This paper describes the measurement and test research on the bed shear stress in a long launder of direct current by the new instrument named thermal shearometer based on micro-nanotechnology. As shown by the research results, the thermal shearometer has a high response frequency and strong stability. The measured results can reflect the basic change of the bed shear stress under wave and wave-current effect, and confirm that the method of measuring bed shear stress under wave-current effect with thermal shearometer is feasible. Meanwhile, a preliminary method to compute the shear stress compounded by wave-current is put forward according to the tested and measured results, and then a reference for further study on the basic theory of sediment movement under a complicated dynamic effect is provided.

  9. Mindfulness-Based Stress Reduction and Transcendental Meditation: Current State of Research

    Directory of Open Access Journals (Sweden)

    Adam Holt

    2015-04-01

    Full Text Available This article summarizes the current state of meditation research, specifically focusing on mindfulness-based stress reduction and transcendental meditation. Despite significant methodological problems with the studies reported to date on the subject, there is consistent evidence that meditation can produce changes in the nervous system and physiology of the meditator, and can help with various psychological markers of well-being. Regarding improvement in specific clinical diseases, research is generally mixed and preliminary. Strong recommendations cannot be made based on current evidence, and further studies are needed. In general, there is a stronger body of evidence supporting mindfulness-based stress reduction than for transcendental meditation.

  10. Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy.

    Science.gov (United States)

    Shao, Hui; Yang, Yang; Mi, Ze; Zhu, Guang-Xi; Qi, Ai-Ping; Ji, Wei-Gang; Zhu, Zhi-Ru

    2016-11-19

    Rhynchophylline (RIN) is a significant active component isolated from the Chinese herbal medicine Uncaria rhynchophylla. Several studies have demonstrated that RIN has a significant anticonvulsant effect in many types of epilepsy models in vivo. However, the mechanisms of the anticonvulsant effect remain elusive. Using combined methods of behavioral testing, immunofluorescence and electrophysiological recordings, we characterized the anticonvulsant effect of RIN in a pilocarpine-induced status epilepticus (SE) rat model of temporal lobe epilepsy (TLE) and investigated the underlying cellular mechanisms. In one set of experiments, rats received RIN treatment prior to pilocarpine injection. In a second set of experiments, rats received RIN treatment following the onset of stage 3 seizures. Pretreatment and posttreatment with RIN effectively reduced the seizure severity in the acute phase of TLE. Furthermore, RIN protected medial entorhinal cortex (mEC) layer III neurons from neuronal death and terminated spontaneous epileptiform discharge of mEC layer II neurons in SE-experienced rats. Whole-cell voltage-clamp recordings indicated that RIN inhibited neuronal hyperexcitability via inhibition of the persistent sodium current (INaP) and NMDA receptor current. Immunofluorescence experiments also demonstrated that RIN rectified the pilocarpine-induced upregulation of Nav1.6 and NR2B protein expression. In conclusion, our results identified RIN as an anticonvulsant agent that inhibited ictal discharge via INap and NMDA receptor current inhibition.

  11. Research on the induction motor current signature for centrifugal pump at cavitation condition

    Directory of Open Access Journals (Sweden)

    Yin Luo

    2015-11-01

    Full Text Available Cavitation is a major undesirable phenomenon for centrifugal pump because it can cause hydraulic performance deterioration, pump damage by pitting and material erosion, and structural vibration and noise. Cavitation can appear within the entire range of the operating conditions; therefore, it must be prevented by all means. Sensorless monitoring technology based on motor current signature analysis is non-intrusive and economic for monitoring motor-driven equipment. Thus, this technology is suitable for centrifugal pump systems. The motor current signature for centrifugal pump load at the cavitation condition is the basis of this technology. However, systematic research is lacking on sensorless monitoring technology based on motor current signature. As a result, the tentative exploration for motor current signature at cavitation load was conducted in this study. The results show that the stator current is still a sinusoidal alternating current strictly to the law of sine. Moreover, the root mean square of the current fluctuates because of different flow regimes in the cavitation progress and decreases because vapor density is smaller than water density when cavitation is fully formed. For the stator current spectrum, the noise level, noise distribution, rotation speed, and vane pass frequency components show features in the cavitation process. These indicator indexes change according to the stage of cavitation development. Thus, the motor current signature analysis is found to be a feasible and cost-effective method for the stages of cavitation condition.

  12. Retrospectives, current valences and prospective dimensions of research at the Academy of Public Administration

    Directory of Open Access Journals (Sweden)

    Aurel SÎMBOTEANU

    2016-12-01

    Full Text Available The present study is an attempt to identify the social determinants, which initiated and facilitated the content and evolution of the scientific research of the administrative phenomenon in the Republic of Moldova after the declaration of independence. It also elucidates the current valences and perspectives of this activity in the context of the provisions of the recently adopted Research Strategy of the Academy of Public Administration for the period 2016-2020.

  13. Clinical outcome and efficacy of current anti-leukemic therapy for leptomeningeal involvement in acute myeloid leukemia.

    Science.gov (United States)

    Kwon, Ji Hyun; Koh, Young-Il; Yoon, Sung-Soo; Park, Seonyang; Kim, Inho

    2016-11-01

    We investigated risk factors and outcome in acute myeloid leukemia (AML) patients with leptomeningeal involvement. Medical records of patients with non-promyelocytic AML at Seoul National University Hospital from January of 2000 to November of 2013 were reviewed. Leptomeningeal involvement was defined as the presence of atypical or malignant hematopoietic cells in the cerebrospinal fluid. Among 775 patients with AML, 141 patients (18.2 %) underwent cerebrospinal fluid examination. Leptomeningeal involvement of AML, confirmed in 38 patients (4.9 %), was associated with high white blood cell count and high level of lactic. There were seven patients in the favorable risk group (19.4 %), 21 in the intermediate risk group (58.3 %), and eight in the adverse risk group (22.2 %). Twenty-eight patients (85.7 %) developed leptomeningeal involvement during relapse status or refractory status. Thirty-one patients (81.6 %) received intrathecal chemotherapy, and whole-brain and/or craniospinal radiotherapy was conducted in 10 patients (27.0 %). The rate of complete remission after induction chemotherapy was 63.2 %. Median overall survival was 9.9 months. Radiotherapy and complete remission after the first induction chemotherapy were associated with longer overall survival. Leptomeningeal involvement in acute myeloid leukemia is rare, but relatively common in relapsed status or refractory status. Craniospinal radiotherapy and complete remission after induction chemotherapy were found to favorable prognostic factors.

  14. Temperature estimation in a ferromagnetic Fe-Ni nanowire involving a current-driven domain wall motion.

    Science.gov (United States)

    Yamaguchi, A; Hirohata, A; Ono, T; Miyajima, H

    2012-01-18

    We observed a magnetic domain wall (DW) motion induced by the spin-polarized pulsed current in a nanoscale Fe(19)Ni(81) wire using a magnetic force microscope. High current density, which is of the order of 10(11) A m(-2), was required for the DW motion. A simple method to estimate the temperature of the wire was developed by comparing the wire resistance measured during the DW motion with the temperature dependence of the wire resistance. Using this method, we found the temperature of the wire was proportional to the square of the current density and became just beneath at the threshold Curie temperature. Our experimental data qualitatively support this analytical model that the temperature is proportional to the resistivity, thickness, width of the wire and the square of the current density, and also inversely proportional to the thermal conductivity.

  15. Evolutionary multi-objective optimization: some current research trends and topics that remain to be explored

    Institute of Scientific and Technical Information of China (English)

    Carlos A. COELLO COELLO

    2009-01-01

    This paper provides a short review of some of the main topics in which the current research in evolutionary multi-objective optimization is being focused. The topics discussed include new algorithms, efficiency, relaxed forms of dominance, scalability, and alternative metaheuristics. This discussion motivates some further topics which,from the author's perspective, constitute good potential areas for future research, namely, constraint-handling techniques,incorporation of user's preferences and parameter control,This information is expected to be useful for those interested in pursuing research in this area.

  16. A few perspectives of solar physics research in China - current status and future

    Science.gov (United States)

    Wang, Jingxiu; Ding, Mingde; Ji, Haisheng; Deng, Yuanyong; Liu, Yu; Liu, Zhong; Qu, Zhongquan; Wang, Huaning; Xia, Lidong; Yan, Yihua

    2016-07-01

    Solar physics research as an important discipline in astrophysics in China aims at improving the understanding of origin and variation of solar magnetic field and magnetic activity, and founding the basis for forecast of disastrous space weather. The current review is focused on the solar physics research in China in recent three years. Highlights in scientific research in solar magnetism, magnetic activity, coronal plasma, and space weather forecast are briefly summarized. Key advances in instrument development are reported in some necessary details. Future tendency and working direction are considered and discussed.

  17. Review of Current Status and Research Approaches to Nitrogen Pollution in Farmlands

    Institute of Scientific and Technical Information of China (English)

    NIE Sheng-wei; GAO Wang-sheng; CHEN Yuan-quan; SUI Peng; A Egrinya Eneji

    2009-01-01

    In this paper, the history, current status, and research approaches to nitrogen pollution were reviewed using systems analysis and deductions. The seriousness of N pollution world-wide was highlighted and recommendations were made to address the situation. A new hypothesis based on phytoremediation, which means the use of plants to directly or indirectly degrade or remove contaminats from soil and water, was proposed.

  18. Gravitational radiation theory. M.A. Thesis - Rice Univ.; [survey of current research

    Science.gov (United States)

    Wilson, T. L.

    1973-01-01

    A survey is presented of current research in the theory of gravitational radiation. The mathematical structure of gravitational radiation is stressed. Furthermore, the radiation problem is treated independently from other problems in gravitation. The development proceeds candidly through three points of view - scalar, rector, and tensor radiation theory - and the corresponding results are stated.

  19. Current status of neutron activation analysis using the Dalat Nuclear Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen Van Suc; Nguyen Mong Sinh [Nuclear Research Institute, Dalat (Viet Nam)

    1999-10-01

    Neutron activation analysis is one of the most sensitive, rapid, accurated methods for determination of trace elements in different materials. A review is made of the current status of the activities and the results in studying and developing NAA (Neutron Activation Analysis) at the Dalat Nuclear Research Institute and applying this method to different sectors of science and technology in Vietnam. (author)

  20. Current status and progress of research on the management of bean ...

    African Journals Online (AJOL)

    ©2000 National Agricultural Research Organisation. Current status ... Them a in ohj ective of this study was to identify control measures that can reduce the disease on ... practices in controlling root rot was carried out in 1997 for two seasons ...

  1. First Language Transfer in Second Language Writing: An Examination of Current Research

    Science.gov (United States)

    Karim, Khaled; Nassaji, Hossein

    2013-01-01

    First language (L1) transfer has been a key issue in the field of applied linguistics, second language acquisition (SLA), and language pedagogy for almost a century. Its importance, however, has been re-evaluated several times within the last few decades. The aim of this paper is to examine current research that has investigated the role of L1…

  2. Fusarium mycotoxins: Current research at the USDA ARS Mycotoxin Prevention unit

    Science.gov (United States)

    Due to the health and economic costs of mycotoxins produced by Fusarium species, there is a compelling need for improved understanding of these fungi, from across diverse perspectives and disciplinary approaches. Current research at the USDA ARS Mycotoxin Prevention unit addresses Fusarium mycotoxin...

  3. Radioprotective drugs: a synopsis of current research and a proposed research plan for the Federal Emergency Management Agency. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hickman, R.; Anspaugh, L.

    1985-04-01

    FEMA has broad roles in the management of disasters potentially involving substantial amounts of radioactive contamination. These could be either peacetime or wartime disasters. A meeting was held in March 1985 to see if there are any research contributions that FEMA might reasonably make in the area of radioprotective drugs that would substantially enhance its ability to perform its mission. The other federal agencies presently sponsoring research in the field were represented at the meeting. A few selected researchers also participated to provide complementary viewpoints. Activities of a modest scale that FEMA might undertake were identified, as were larger scale activities that might be undertaken in the event of long-term, major funding-level increases for FEMA. 2 refs.

  4. The emergence and current performance of a health research system: lessons from Guinea Bissau

    Directory of Open Access Journals (Sweden)

    Kok Maarten O

    2012-02-01

    Full Text Available Abstract Background Little is known about how health research systems (HRS in low-income countries emerge and evolve over time, and how this process relates to their performance. Understanding how HRSs emerge is important for the development of well functioning National Health Research Systems (NHRS. The aim of this study was to assess how the HRS in Guinea Bissau has emerged and evolved over time and how the present system functions. Methods We used a qualitative case-study methodology to explore the emergence and current performance of the HRS, using the NHRS framework. We reviewed documents and carried out 39 in-depth interviews, ranging from health research to policy and practice stakeholders. Using an iterative approach, we undertook a thematic analysis of the data. Results The research practices in Guinea Bissau led to the emergence of a HRS with both local and international links and strong dependencies on international partners and donors. The post-colonial, volatile and resource-dependent context, changes in donor policies, training of local researchers and nature of the research findings influenced how the HRS evolved. Research priorities have mostly been set by 'expatriate' researchers and focused on understanding and reducing child mortality. Research funding is almost exclusively provided by foreign donors and international agencies. The training of Guinean researchers started in the mid-nineties and has since reinforced the links with the health system, broadened the research agenda and enhanced local use of research. While some studies have made an important contribution to global health, the use of research within Guinea Bissau has been constrained by the weak and donor dependent health system, volatile government, top-down policies of international agencies, and the controversial nature of some of the research findings. Conclusions In Guinea Bissau a de facto 'system' of research has emerged through research practices and co

  5. Statistical research on the motion properties of the magnetotail current sheet:Cluster observations

    Institute of Scientific and Technical Information of China (English)

    H.REME; E.LUCEK

    2010-01-01

    The origin of the flapping motion of the earth’s magnetotail current sheet is one of the most important problems in the magnetotail dynamics.Using Cluster data,we make a statistical research on the motion properties of the magnetotail current sheet of 2001 and 2003.We calculate the velocities of the magnetotail current sheet using new methods and obtain the distribution of the magnetotail current sheet velocities in the X-Y plane in GSE coordinate system.Our results show that although most of the current sheets were propagating toward the tail flanks and those of the exceptions lay in dusk side,which is consistent with previous studies,the proportions of the current sheet which were propagating toward midnight (where |YGSE|=0) were higher than those in previous studies.Motions of the current sheet in the middle area (|YGSE|<8 Re) of the magnetotail are investigated.Relatively high value of the Z component of the velocity further confirms that the middle area of the magnetotail might be a source region for the motion of the current sheets which were propagating towards the tail flanks.According to our case studies,the way the current sheets propagated toward midnight area differs significantly from that toward dusk and dawn side,from which we infer that there might be two different kinds of current sheet motions originated from different sources.The statistical results of this paper may give some clues for further studies on the origin of the flapping motion of the magnetotail current sheet.

  6. Current Researches on the Methods of Diagnosing Sasang Constitution: An Overview

    Directory of Open Access Journals (Sweden)

    Si-Woo Lee

    2009-01-01

    Full Text Available Sasang constitution diagnosis has traditionally been conducted by a Sasang constitutional medicine (SCM doctor who examines the external appearance, temperament and various symptoms of an individual and then collectively analyzes this information to determine their own constitutions. However, because this process is subjective and not quantitative, many researchers have been attempting to develop objective and reasonable methods of determining constitutions. In Korea, even though a wide range of research regarding SCM has been conducted, most of the work has not been revealed internationally. So in this review, the authors have searched the Journal of Sasang Constitutional Medicine, as well as other Korean domestic journal databases and Pubmed for research regarding modernized constitution diagnosis methods so to provide the understanding of current research state and outlook for future research.

  7. African swine fever virus: current state and future perspectives in vaccine and antiviral research.

    Science.gov (United States)

    Zakaryan, Hovakim; Revilla, Yolanda

    2016-03-15

    African swine fever (ASF) is among the most significant of swine diseases for which no effective vaccines and antivirals are available. The disease, which is endemic in Africa, was introduced to Trans-Caucasian countries and the Russian Federation in 2007, where it remains prevalent today among domestic pigs and wild boars. Although some measures were implemented, ASF continues to pose a global risk for all countries, and thereby highlighting the importance of vaccine and antiviral research. In this review, an overview of research efforts toward the development of effective vaccines during the past decades is presented. As an alternative to vaccine development, the current state in antiviral research against ASFV is also presented. Finally, future perspectives in vaccine and antiviral research giving emphasis on some strategies that may allow researchers to develop effective countermeasures against ASF are discussed.

  8. The Evolution of Current Research Impact Metrics: From Bibliometrics to Altmetrics?

    Science.gov (United States)

    Butler, Joseph S; Kaye, I David; Sebastian, Arjun S; Wagner, Scott C; Morrissey, Patrick B; Schroeder, Gregory D; Kepler, Christopher K; Vaccaro, Alexander R

    2017-03-23

    The prestige of publication has been based on traditional citation metrics, most commonly journal impact factor. However, the Internet has radically changed the speed, flow, and sharing of medical information. Furthermore, the explosion of social media, along with development of popular professional and scientific websites and blogs, has led to the need for alternative metrics, known as altmetrics, to quantify the wider impact of research. We explore the evolution of current research impact metrics and examine the evolving role of altmetrics in measuring the wider impact of research. We suggest that altmetrics used in research evaluation should be part of an informed peer-review process such as traditional metrics. Moreover, results based on altmetrics must not lead to direct decision making about research, but instead, should be used to assist experts in making decisions. Finally, traditional and alternative metrics should complement, not replace, each other in the peer-review process.

  9. [Pathological gambling and computergame-addiction. Current state of research regarding two subtypes of behavioural addiction].

    Science.gov (United States)

    Wölfling, K; Müller, K W

    2010-04-01

    Behavioral addictions, like pathological gambling and computer game addiction (or internet addiction), have become a growing concern in research and public interest. Currently similarities between behavioral addictions and substance dependency are controversially discussed in the scientific community. Unfortunately a mismatch exists between the large number of people seeking treatment and the small number of scientific studies on pathological gambling and computer game addiction. Prevalence of pathological gambling among the German population is estimated to be 0.2-0.5%. These estimations are comparable to prevalence rates reported for drug dependency. Latest research states that about 3% of German adolescents and young adults are believed to suffer from computer game addiction. Therefore, it is important to enhance investigations regarding the clinical and neuroscientific basis of computer game addiction. This review offers a summary of current results of research regarding pathological gambling and internet addiction. The phenomenological description of these two disorders is meant to allow a deeper understanding of behavioral addictions.

  10. 40 CFR 26.303 - Duties of IRBs in connection with observational research involving pregnant women and fetuses.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Duties of IRBs in connection with observational research involving pregnant women and fetuses. 26.303 Section 26.303 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Observational Research: Additional Protections for Pregnant Women and...

  11. Affective States and Performance Outcomes – The Findings of Preliminary Research Involving Pentathletes

    Directory of Open Access Journals (Sweden)

    Samełko Aleksandra

    2016-03-01

    Full Text Available Introduction. The aim of this article is to discuss the relationship between affective states experienced by athletes and the outcome of their performance. The article presents the findings of a pilot study which made it possible to determine the relationship between the emotional states, mood, and level of stress of a group of pentathletes and the outcomes they achieved in a sports competition. Material and methods. The study involved 12 senior modern pentathletes, including 7 male and 5 female athletes. The following standard psychology questionnaires were used in the study: the 10-item Perceived Stress Scale (PSS-10, the Positive and Negative Affect Schedule (PANAS, and the Profile of Mood State (POMS. Performance was assessed based on the number of points achieved by the pentathletes in particular events in the pentathlon, which are held according to the rules set by the International Modern Pentathlon Union (UIPM. Results. The findings of the study confirmed that there was a correlation between the athletes’ mood and emotions and the outcome of their performance. The level of stress strongly negatively correlated with both the outcome they expected to achieve and the one they actually achieved for the combined event (running and shooting. For this event a relationship was also found between the athletes’ affective states and their outcomes: in running and shooting there was a positive and statistically significant correlation between the level of positive emotions and anger and the results achieved. However, friendliness, one of the other affective state variables that were measured, correlated negatively with the outcomes of the athletes’ performance. Conclusions. In the group of pentathletes who participated in the study, a high level of anger was associated with better outcomes, and a high level of friendliness had an adverse effect on the results achieved. The findings of the current study confirm that there is a relationship

  12. Service user involvement enhanced the research quality in a study using interpretative phenomenological analysis - the power of multiple perspectives.

    Science.gov (United States)

    Mjøsund, Nina Helen; Eriksson, Monica; Espnes, Geir Arild; Haaland-Øverby, Mette; Jensen, Sven Liang; Norheim, Irene; Kjus, Solveig Helene Høymork; Portaasen, Inger-Lill; Vinje, Hege Forbech

    2017-01-01

    The aim of this study was to examine how service user involvement can contribute to the development of interpretative phenomenological analysis methodology and enhance research quality. Interpretative phenomenological analysis is a qualitative methodology used in nursing research internationally to understand human experiences that are essential to the participants. Service user involvement is requested in nursing research. We share experiences from 4 years of collaboration (2012-2015) on a mental health promotion project, which involved an advisory team. Five research advisors either with a diagnosis or related to a person with severe mental illness constituted the team. They collaborated with the research fellow throughout the entire research process and have co-authored this article. We examined the joint process of analysing the empirical data from interviews. Our analytical discussions were audiotaped, transcribed and subsequently interpreted following the guidelines for good qualitative analysis in interpretative phenomenological analysis studies. The advisory team became 'the researcher's helping hand'. Multiple perspectives influenced the qualitative analysis, which gave more insightful interpretations of nuances, complexity, richness or ambiguity in the interviewed participants' accounts. The outcome of the service user involvement was increased breadth and depth in findings. Service user involvement improved the research quality in a nursing research project on mental health promotion. The interpretative element of interpretative phenomenological analysis was enhanced by the emergence of multiple perspectives in the qualitative analysis of the empirical data. We argue that service user involvement and interpretative phenomenological analysis methodology can mutually reinforce each other and strengthen qualitative methodology. © 2016 The Authors. Journal of Advanced Nursing Published by John Wiley & Sons Ltd.

  13. Experimental Research of Harmonic Spectrum of Currents at Traction Drive with PMSM

    Directory of Open Access Journals (Sweden)

    J. Novak

    2011-06-01

    Full Text Available The paper deals with the significant results of the experimental research of current harmonic spectrum of traction drive with permanent magnet synchronous motor. The experiments were done on a special workplace with a real traction drive for wheel vehicles. Current harmonic spectrum was analyzed by a specialized device on the base of central measuring station. The knowledge of current marked subharmonic components of stator winding is the most significant finding of experiments. The frequencies of these components are given by multiples of frequency of mechanical speeds. The subharmonic components also pass to input DC current of drive. This fact is important in particular from the point of view of legislative requirements to electromagnetic compatibility of drive with railway interlocking devices.

  14. The value of value of information: best informing research design and prioritization using current methods.

    Science.gov (United States)

    Eckermann, Simon; Karnon, Jon; Willan, Andrew R

    2010-01-01

    Value of information (VOI) methods have been proposed as a systematic approach to inform optimal research design and prioritization. Four related questions arise that VOI methods could address. (i) Is further research for a health technology assessment (HTA) potentially worthwhile? (ii) Is the cost of a given research design less than its expected value? (iii) What is the optimal research design for an HTA? (iv) How can research funding be best prioritized across alternative HTAs? Following Occam's razor, we consider the usefulness of VOI methods in informing questions 1-4 relative to their simplicity of use. Expected value of perfect information (EVPI) with current information, while simple to calculate, is shown to provide neither a necessary nor a sufficient condition to address question 1, given that what EVPI needs to exceed varies with the cost of research design, which can vary from very large down to negligible. Hence, for any given HTA, EVPI does not discriminate, as it can be large and further research not worthwhile or small and further research worthwhile. In contrast, each of questions 1-4 are shown to be fully addressed (necessary and sufficient) where VOI methods are applied to maximize expected value of sample information (EVSI) minus expected costs across designs. In comparing complexity in use of VOI methods, applying the central limit theorem (CLT) simplifies analysis to enable easy estimation of EVSI and optimal overall research design, and has been shown to outperform bootstrapping, particularly with small samples. Consequently, VOI methods applying the CLT to inform optimal overall research design satisfy Occam's razor in both improving decision making and reducing complexity. Furthermore, they enable consideration of relevant decision contexts, including option value and opportunity cost of delay, time, imperfect implementation and optimal design across jurisdictions. More complex VOI methods such as bootstrapping of the expected value of

  15. Research on resistance characteristics of YBCO tape under short-time DC large current impact

    Science.gov (United States)

    Zhang, Zhifeng; Yang, Jiabin; Qiu, Qingquan; Zhang, Guomin; Lin, Liangzhen

    2017-06-01

    Research of the resistance characteristics of YBCO tape under short-time DC large current impact is the foundation of the developing DC superconducting fault current limiter (SFCL) for voltage source converter-based high voltage direct current system (VSC-HVDC), which is one of the valid approaches to solve the problems of renewable energy integration. SFCL can limit DC short-circuit and enhance the interrupting capabilities of DC circuit breakers. In this paper, under short-time DC large current impacts, the resistance features of naked tape of YBCO tape are studied to find the resistance - temperature change rule and the maximum impact current. The influence of insulation for the resistance - temperature characteristics of YBCO tape is studied by comparison tests with naked tape and insulating tape in 77 K. The influence of operating temperature on the tape is also studied under subcooled liquid nitrogen condition. For the current impact security of YBCO tape, the critical current degradation and top temperature are analyzed and worked as judgment standards. The testing results is helpful for in developing SFCL in VSC-HVDC.

  16. Assessing the influence of researcher-partner involvement on the process and outcomes of participatory research in autism spectrum disorder and neurodevelopmental disorders: a scoping review.

    Science.gov (United States)

    Jivraj, Jamil; Sacrey, Lori-Ann; Newton, Amanda; Nicholas, David; Zwaigenbaum, Lonnie

    2014-10-01

    Participatory research aims to increase the relevance and broaden the implementation of health research by involving those affected by the outcomes of health studies. Few studies within the field of neurodevelopmental disorders, particularly autism spectrum disorders, have involved autistic individuals as partners. This study sought to identify and characterize published participatory research partnerships between researchers and individuals with autism spectrum disorder or other neurodevelopmental disorders and examine the influence of participatory research partnerships on the research process and reported study outcomes. A search of databases and review of gray literature identified seven studies that described participatory research partnerships between academic researchers and individuals with autism spectrum disorder or other neurodevelopmental disorders. A comparative analysis of the studies revealed two key themes: (1) variations in the participatory research design and (2) limitations during the reporting of the depth of the partner's involvement. Both themes potentially limit the application and generalizability of the findings. The results of the review are discussed in relation to the use of evaluative frameworks for such participatory research studies to determine the potential benefits of participatory research partnerships within the neurodevelopmental and autism spectrum disorder populations.

  17. ACOG committee opinion: ethical considerations in research involving women. Number 290, November 2003: Committee on Ethics.

    Science.gov (United States)

    2004-07-01

    In this Committee Opinion, the American College of Obstetricians and Gynecologists Committee on Ethics affirms both the need for women to serve as research participants and the obligation for researchers, institutional review boards, and others reviewing clinical research to evaluate the potential effect of proposed research on women of childbearing potential, pregnant women, and the developing fetus.

  18. Fuel-coolant interaction (FCI) phenomena in reactor safety. Current understanding and future research needs

    Energy Technology Data Exchange (ETDEWEB)

    Speis, T.P. [Maryland Univ., College Park, MD (United States); Basu, S.

    1998-01-01

    This paper gives an account of the current understanding of fuel-coolant interaction (FCI) phenomena in the context of reactor safety. With increased emphasis on accident management and with emerging in-vessel core melt retention strategies for advanced light water reactor (ALWR) designs, recent interest in FCI has broadened to include an evaluation of potential threats to the integrity of reactor vessel lower head and ex-vessel structural support, as well as the role of FCI in debris quenching and coolability. The current understanding of FCI with regard to these issues is discussed, and future research needs to address the issues from a risk perspective are identified. (author)

  19. Current thinking in qualitative research: evidence-based practice, moral philosophies, and political struggle.

    Science.gov (United States)

    Papadimitriou, Christina; Magasi, Susan; Frank, Gelya

    2012-01-01

    In this introduction to the special issue on current thinking in qualitative research and occupational therapy and science, the authors focus on the importance of rigorous qualitative research to inform occupational therapy practice. The authors chosen for this special issue reflect a "second generation of qualitative researchers" who are critical, theoretically sophisticated, methodologically productive, and politically relevant to show that working with disabled clients is political work. Three themes emerged across the articles included in this special issue: (1) recognizing and addressing social justice issues; (2) learning from clients' experiences; and (3) critically reframing occupational therapy's role. These themes can inform occupational therapy practice, research, and education to reflect a more client-centered and politically engaging approach. Copyright 2012, SLACK Incorporated.

  20. Person-centred health care: a critical assessment of current and emerging research approaches.

    Science.gov (United States)

    Martin, Carmel M; Félix-Bortolotti, Margot

    2014-12-01

    Person-centred health care is prominent in international health care reforms. A shift to understanding and improving personal care at the point of delivery has generated debates about the nature of the person-centred research agenda. This paper purviews research paradigms that influence current person-centred research approaches and traditions that influence knowledge foundations in the field. It presents a synthesis of the emergent approaches and methodologies and highlights gaps between static academic research and the increasing accessibility of evaluation, informatics and big data from health information systems. Paradigms in health services research range from theoretical to atheoretical, including positivist, interpretive, postmodern and pragmatic. Interpretivist (subjective) and positivist (objectivist) paradigms have been historically polarized. Yet, integrative and pragmatic approaches have emerged. Nevertheless, there is a tendency to reductionism, and to reduce personal experiences to metrics in the positivist paradigm. Integrating personalized information into clinical systems is increasingly driven by the pervasive health information technology, which raises many issues about the asymmetry and uncertainty in the flow of information to support personal health journeys. The flux and uncertainty of knowledge between and within paradigmatic or pragmatic approaches highlights the uncertainty and the 'unorder and disorder' in what is known and what it means. Transdisciplinary, complex adaptive systems theory with multi-ontology sense making provides an overarching framework for making sense of the complex dynamics in research progress. A major challenge to current research paradigms is focus on the individualizing of care and enhancing experiences of persons in health settings. There is an urgent need for person-centred research to address this complex process. A transdisciplinary and complex systems approach provides a sense-making framework. © 2014 John

  1. The State of the Empirical Research Literature on Stakeholder Involvement in Program Evaluation

    Science.gov (United States)

    Brandon, Paul R.; Fukunaga, Landry L.

    2014-01-01

    Evaluators widely agree that stakeholder involvement is a central aspect of effective program evaluation. With the exception of articles on collaborative evaluation approaches, however, a systematic review of the breadth and depth of the literature on stakeholder involvement has not been published. In this study, we examine peer-reviewed empirical…

  2. Critical Entanglement: Research on Culturally and Linguistically Diverse Parental Involvement in Special Education 2000-2010

    Science.gov (United States)

    Cobb, Cam

    2014-01-01

    If parental involvement in a child's education is generally viewed in positive terms, then it is important to understand what sorts of barriers might hinder it. This article reviews literature on culturally and linguistically diverse parental involvement in special education in the United States and Canada. In analyzing 20 articles published in…

  3. Critical Entanglement: Research on Culturally and Linguistically Diverse Parental Involvement in Special Education 2000-2010

    Science.gov (United States)

    Cobb, Cam

    2014-01-01

    If parental involvement in a child's education is generally viewed in positive terms, then it is important to understand what sorts of barriers might hinder it. This article reviews literature on culturally and linguistically diverse parental involvement in special education in the United States and Canada. In analyzing 20 articles published…

  4. [Current situation of toxicity classification of Chinese materia medica and its research thoughts].

    Science.gov (United States)

    Sun, Wenyan; Hou, Xiujuan; Wang, Bin; Zhu, Yuelan; Zhang, Shuofeng; Chang, Hongsheng; Sun, Jianning

    2012-08-01

    Toxicity of Chinese materia medica (CMM) is an important part of Chinese herbal nature theory. In clinical application, the dosage, time limitation and compatibility of CMM is mainly determined by toxicity. At present, there is no uniform toxicity classification standard for the evaluation of Chinese herbal toxicity. Therefore, it is significant to research toxicity classification of CMM. The current situation of toxicity classification of CMM is reviewed in this paper, and proposed research thoughts are as follows: the measurement of toxicity parameters, the confirmation of poisoning target organs, the investigation on toxic mechanism by serum pharmacology and toxicokinetics, the comprehensive evaluation on toxicity based on quantitative theory.

  5. The current state of the art of quantitative phosphoproteomics and its applications to diabetes research

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Chi Yuet X’avia; Gritsenko, Marina A.; Smith, Richard D.; Qian, Wei-Jun

    2016-03-17

    Protein phosphorylation is a fundamental regulatory mechanism in many cellular processes and aberrant perturbation of phosphorylation has been revealed in various human diseases. Kinases and their cognate inhibitors have been hotspot for drug development. Therefore, the emerging tools, which enable a system-wide quantitative profiling of phosphoproteome, would offer a powerful impetus in unveiling novel signaling pathways, drug targets and/or biomarkers for the disease of interest. In this review, we will highlight recent advances in phosphoproteomics, the current state-of-the-art of the technologies, and the challenges and future perspectives of this research area. Finally, we will underscore some exemplary applications of phosphoproteomics in diabetes research.

  6. The current state of the art of quantitative phosphoproteomics and its applications to diabetes research.

    Science.gov (United States)

    Chan, Chi Yuet X'avia; Gritsenko, Marina A; Smith, Richard D; Qian, Wei-Jun

    2016-01-01

    Protein phosphorylation is a fundamental regulatory mechanism in many cellular processes and aberrant perturbation of phosphorylation has been implicated in various human diseases. Kinases and their cognate inhibitors have been considered as hotspots for drug development. Therefore, the emerging tools, which enable a system-wide quantitative profiling of phosphoproteome, would offer a powerful impetus in unveiling novel signaling pathways, drug targets and/or biomarkers for diseases of interest. This review highlights recent advances in phosphoproteomics, the current state of the art of the technologies and the challenges and future perspectives of this research area. Finally, some exemplary applications of phosphoproteomics in diabetes research are underscored.

  7. Central centrifugal cicatricial alopecia: what has been achieved, current clues for future research.

    Science.gov (United States)

    Ogunleye, Temitayo A; McMichael, Amy; Olsen, Elise A

    2014-04-01

    Central centrifugal cicatricial alopecia is an inflammatory type of central scalp hair loss seen primarily in women of African descent. The prevalence is unknown, but may vary from 2.7% to 5.7% and increases with age. This review outlines the history and current beliefs and identifies clues for future research for this enigmatic condition. Despite that the cause of central centrifugal cicatricial alopecia is unknown, research is ongoing. The role of cytokeratins, androgens, genetics, and various possible sources of chronic inflammation in disease pathogenesis remain to be elucidated.

  8. Current Research and Classroom Practice: Toward More Inclusive Approaches to Literacy Development in Schools

    Directory of Open Access Journals (Sweden)

    David Booth

    2009-07-01

    Full Text Available This paper offers an exploration of current research and related practice in boys’ literacy development, interprets key findings in the literature, and further explores some of the complex dilemmas and debates related to the ‘gender gap’ – i.e., differences between the achievement of boys and girls in this area. In conclusion, the authors suggest that governments, policy-makers, administrators, teachers and parents all need to closely examine and consider available research-based strategies and classroom interventions that can effectively support both boys and girls in their literacy development. 

  9. Mandates, needs, equitable resources, and current research in English language teacher education: The case of Turkey

    Directory of Open Access Journals (Sweden)

    Saban Cepik

    2014-02-01

    Full Text Available Improving the quality of English language teacher education (ELTE programs has become a major point of consideration; however, such programmatic evaluations are markedly rare. This study utilizes both numeric and interpretive qualitative data in a blended research design. The study addresses, vis-à-vis current research in related fields: What is the current situation of the Turkish ELTE programs in terms of curriculum strength and faculty resources? How do the program directors and teacher candidates envision the situation of their programs in terms of curriculum strength and faculty resources? Data included 45 ELTE curricula, interviews with 24 program directors and pre-service teachers, documents, and test scores. Findings revealed several significant associations between school type (public/private and rank (low/high and the number of faculty with expertise in critical areas in the field. Qualitative critical evaluations suggest both perceptual matches and mismatches between program directors and teacher candidates regarding programmatic strengths and weaknesses.

  10. Regeneration of tissues of the oral complex: current clinical trends and research advances.

    Science.gov (United States)

    Nguyen, Thomas T; Mui, Brennan; Mehrabzadeh, Mahsa; Chea, Yannie; Chaudhry, Zoya; Chaudhry, Kamran; Tran, Simon D

    2013-01-01

    Regenerative therapy in oral health care is limited by both the body's natural capacity for regeneration and the materials and methods currently available. Research on various aspects of regenerative therapy, such as tissue engineering and stem cell and gene therapy, has produced promising results. Compelling advances, ranging from the discovery and characterization of stem cell populations in oral tissue to the engineering and transplantation of whole tooth structures, could result in exciting new treatment methods for clinicians in the near future. In this review, we discuss the limitations of natural healing and regeneration of various tissues of the oral complex, including teeth, periodontium and salivary glands, and summarize current treatment methods for tissue damage as well as research advances in oral tissue regeneration.

  11. Grand Research Plan for Neural Circuits of Emotion and Memory-Current status of neural circuit studies in China

    Institute of Scientific and Technical Information of China (English)

    Yuan-Gui Zhu; He-Qi Cao; Er-Dan Dong

    2013-01-01

    During recent years,major advances have been made in neuroscience,i.e.,asynchronous release,three-dimensional structural data sets,saliency maps,magnesium in brain research,and new functional roles of long non-coding RNAs.Especially,the development of optogenetic technology provides access to important information about relevant neural circuits by allowing the activation of specific neurons in awake mammals and directly observing the resulting behavior.The Grand Research Plan for Neural Circuits of Emotion and Memory was launched by the National Natural Science Foundation of China.It takes emotion and memory as its main objects,making the best use of cutting-edge technologies from medical science,life science and information science.In this paper,we outline the current status of neural circuit studies in China and the technologies and methodologies being applied,as well as studies related to the impairments of emotion and memory.In this phase,we are making efforts to repair the current deficiencies by making adjustments,mainly involving four aspects of core scientific issues to investigate these circuits at multiple levels.Five research directions have been taken to solve important scientific problems while the Grand Research Plan is implemented.Future research into this area will be multimodal,incorporating a range of methods and sciences into each project.Addressing these issues will ensure a bright future,major discoveries,and a higher level of treatment for all affected by debilitating brain illnesses.

  12. Where Is Current Research on Blockchain Technology?—A Systematic Review

    Science.gov (United States)

    Yli-Huumo, Jesse; Ko, Deokyoon; Park, Sooyong; Smolander, Kari

    2016-01-01

    Blockchain is a decentralized transaction and data management technology developed first for Bitcoin cryptocurrency. The interest in Blockchain technology has been increasing since the idea was coined in 2008. The reason for the interest in Blockchain is its central attributes that provide security, anonymity and data integrity without any third party organization in control of the transactions, and therefore it creates interesting research areas, especially from the perspective of technical challenges and limitations. In this research, we have conducted a systematic mapping study with the goal of collecting all relevant research on Blockchain technology. Our objective is to understand the current research topics, challenges and future directions regarding Blockchain technology from the technical perspective. We have extracted 41 primary papers from scientific databases. The results show that focus in over 80% of the papers is on Bitcoin system and less than 20% deals with other Blockchain applications including e.g. smart contracts and licensing. The majority of research is focusing on revealing and improving limitations of Blockchain from privacy and security perspectives, but many of the proposed solutions lack concrete evaluation on their effectiveness. Many other Blockchain scalability related challenges including throughput and latency have been left unstudied. On the basis of this study, recommendations on future research directions are provided for researchers. PMID:27695049

  13. Where Is Current Research on Blockchain Technology?-A Systematic Review.

    Science.gov (United States)

    Yli-Huumo, Jesse; Ko, Deokyoon; Choi, Sujin; Park, Sooyong; Smolander, Kari

    2016-01-01

    Blockchain is a decentralized transaction and data management technology developed first for Bitcoin cryptocurrency. The interest in Blockchain technology has been increasing since the idea was coined in 2008. The reason for the interest in Blockchain is its central attributes that provide security, anonymity and data integrity without any third party organization in control of the transactions, and therefore it creates interesting research areas, especially from the perspective of technical challenges and limitations. In this research, we have conducted a systematic mapping study with the goal of collecting all relevant research on Blockchain technology. Our objective is to understand the current research topics, challenges and future directions regarding Blockchain technology from the technical perspective. We have extracted 41 primary papers from scientific databases. The results show that focus in over 80% of the papers is on Bitcoin system and less than 20% deals with other Blockchain applications including e.g. smart contracts and licensing. The majority of research is focusing on revealing and improving limitations of Blockchain from privacy and security perspectives, but many of the proposed solutions lack concrete evaluation on their effectiveness. Many other Blockchain scalability related challenges including throughput and latency have been left unstudied. On the basis of this study, recommendations on future research directions are provided for researchers.

  14. Potential of nanotechnology as a delivery platform against tuberculosis: current research review.

    Science.gov (United States)

    Choudhary, S; Kusum Devi, V

    2015-03-28

    This review focusses on the current ongoing research in the field of tuberculosis comprising the resistant strains. It specifies a proper data analysis with results in concise form from areas gripping in: diagnostic nanotechnology, vaccine nanotechnology and the prime field of interest i.e., therapeutic nanotechnology. Primarily, therapeutic area recollects the research findings from advanced drug delivery (primary era) to the targeted drug delivery (modern era). The vaccine-based area derives the immune-specific targeting with enhanced emphasis on vaccine extraction and preparation of nanoparticles. Finally, the diagnostic area signifies the imaging techniques that may be employed in the diagnosis of TB. Not only that, there are some researches that emphasized on finding the comparable diagnostic differences between normal and resistant strains. With the advent of carbon nanotubes, metallic NPs, a newer hope has emerged out in diagnostic research, which may extend to therapeutic research applications too. Modifications of natural polymers, least or no use of organic solvents, size controlled NPs, optimized methodology, etc., are fields that need more effort to bypass toxicity. If above desired possibilities get the priority during research, it may lead to shift in the timeline towards much more oriented research. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. White Paper on Multicarrier Excitation of Multipactor Breakdown: A Survey of Current Methods and Research Opportunities

    Science.gov (United States)

    2015-06-18

    AEROSPACE REPORT NO. TOR-2015-02548 White Paper on Multicarrier Excitation of Multipactor Breakdown: A Survey of Current Methods and...voltage phenomena where the verification power level is chosen such that the maximum instantaneous operational voltage in the component is excited . In...analysis methods under investigation for multicarrier excitation threshold prediction based on a survey of the research literature. In general, this

  16. MicroRNAs as Biomarkers for Psychiatric Conditions: A Review of Current Research

    Science.gov (United States)

    Hussain, Mariyah; Sreeram, Venkatesh

    2017-01-01

    Neural-derived exosomes can be used as diagnostic markers to screen for various psychiatric conditions. These intravenously injected exosomes carry the potential to cross the blood brain barrier and deliver miRNA molecules specifically to neurons, microglia, and oligodendrocytes in the brain, resulting in specific gene knockdown. Here the authors review and discuss the current research on microRNA molecules and the therapeutic roles they may potentially play in treating depression, bipolar disorder, and schizophrenia.

  17. Improving brain computer interface research through user involvement - The transformative potential of integrating civil society organisations in research projects

    Science.gov (United States)

    Wakunuma, Kutoma; Rainey, Stephen; Hansen, Christian

    2017-01-01

    Research on Brain Computer Interfaces (BCI) often aims to provide solutions for vulnerable populations, such as individuals with diseases, conditions or disabilities that keep them from using traditional interfaces. Such research thereby contributes to the public good. This contribution to the public good corresponds to a broader drive of research and funding policy that focuses on promoting beneficial societal impact. One way of achieving this is to engage with the public. In practical terms this can be done by integrating civil society organisations (CSOs) in research. The open question at the heart of this paper is whether and how such CSO integration can transform the research and contribute to the public good. To answer this question the paper describes five detailed qualitative case studies of research projects including CSOs. The paper finds that transformative impact of CSO integration is possible but by no means assured. It provides recommendations on how transformative impact can be promoted. PMID:28207882

  18. Indian Student Involvement in Tribal Community-Based Research: Underage Drinking Prevention among Rural Native Californians.

    Science.gov (United States)

    Lee, Juliet P; Calac, Daniel; Montag, Annika C; Brodine, Stephanie; Luna, Juan A; Flores, Rosalie Y; Gilder, David A; Moore, Roland S

    2011-01-01

    The critical need for increased numbers of American Indian/Alaska Native scientists and health professionals motivated the development of the California Native American Research Center for Health (CA-NARCH) initiative. One strategy of the initiative has been to encourage opportunities for applied research experiences for American Indian/Alaska Native students. Placement of CA-NARCH students in funded research assistant positions for a research project "Preventing Underage Drinking by Southwest California Indians: Building Capacity" based at the Southern California Tribal Health Clinic, Inc., in a rural part of Southern California, provides a model in which both American Indian//Alaska Native students and research investigators have benefitted. Six students received training in research ethics, data collection methods and data management and analysis. The students' participation in project activities has resulted in positive experiences for themselves, a productive research staff for the project and positive responses from community members to this sensitive research project.

  19. Mapping the impact of patient and public involvement on health and social care research: a systematic review.

    Science.gov (United States)

    Brett, Jo; Staniszewska, Sophie; Mockford, Carole; Herron-Marx, Sandra; Hughes, John; Tysall, Colin; Suleman, Rashida

    2014-10-01

    There is an increasing international interest in patient and public involvement (PPI) in research, yet relatively little robust evidence exists about its impact on health and social care research. To identify the impact of patient and public involvement on health and social care research. A systematic search of electronic databases and health libraries was undertaken from 1995 to 2009. Data were extracted and quality assessed utilizing the guidelines of the NHS Centre for Reviews and Dissemination 2009 and the Critical Appraisal Skills Programme (CASP). Grey literature was assessed using the Dixon-Woods et al. (2005) checklist. All study types that reported the impact PPI had on the health and/or social care research study. A total of 66 studies reporting the impact of PPI on health and social care research were included. The positive impacts identified enhanced the quality and appropriateness of research. Impacts were reported for all stages of research, including the development of user-focused research objectives, development of user-relevant research questions, development of user-friendly information, questionnaires and interview schedules, more appropriate recruitment strategies for studies, consumer-focused interpretation of data and enhanced implementation and dissemination of study results. Some challenging impacts were also identified. This study provides the first international evidence of PPI impact that has emerged at all key stages of the research process. However, much of the evidence base concerning impact remains weak and needs significant enhancement in the next decade. © 2012 John Wiley & Sons Ltd.

  20. International public health research involving interpreters: a case study from Bangladesh

    Directory of Open Access Journals (Sweden)

    van Teijlingen Edwin

    2005-06-01

    Full Text Available Abstract Background Cross-cultural and international research are important components of public health research, but the challenges of language barriers and working with interpreters are often overlooked, particularly in the case of qualitative research. Methods A case-study approach was used to explore experiences of working with an interpreter in Bangladesh as part of a research project investigating women's experiences of emergency obstetric care. The case study Data from the researcher's field notes provided evidence of experiences in working with an interpreter and show how the model of interviewing was adapted over time to give a more active role to the interpreter. The advantages of a more active role were increased rapport and "flow" in interviews. The disadvantages included reduced control from the researcher's perspective. Some tensions between the researcher and interpreter remained hard to overcome, irrespective of the model used. Independent transcription and translation of the interviews also raised questions around accuracy in translation. Conclusion The issues examined in this case study have broader implications for public health research. Further work is needed in three areas: 1 developing effective relationships with interpreters; 2 the impact of the interpreter on the research process; and 3 the accuracy of the translation and level of analysis needed in any specific public health research. Finally, this paper highlights the importance to authors of reflecting on the potential impact of translation and interpretation on the research process when disseminating their research.

  1. JSC Advanced Curation: Research and Development for Current Collections and Future Sample Return Mission Demands

    Science.gov (United States)

    Fries, M. D.; Allen, C. C.; Calaway, M. J.; Evans, C. A.; Stansbery, E. K.

    2015-01-01

    Curation of NASA's astromaterials sample collections is a demanding and evolving activity that supports valuable science from NASA missions for generations, long after the samples are returned to Earth. For example, NASA continues to loan hundreds of Apollo program samples to investigators every year and those samples are often analyzed using instruments that did not exist at the time of the Apollo missions themselves. The samples are curated in a manner that minimizes overall contamination, enabling clean, new high-sensitivity measurements and new science results over 40 years after their return to Earth. As our exploration of the Solar System progresses, upcoming and future NASA sample return missions will return new samples with stringent contamination control, sample environmental control, and Planetary Protection requirements. Therefore, an essential element of a healthy astromaterials curation program is a research and development (R&D) effort that characterizes and employs new technologies to maintain current collections and enable new missions - an Advanced Curation effort. JSC's Astromaterials Acquisition & Curation Office is continually performing Advanced Curation research, identifying and defining knowledge gaps about research, development, and validation/verification topics that are critical to support current and future NASA astromaterials sample collections. The following are highlighted knowledge gaps and research opportunities.

  2. Review of current interest and research in water hyacinth-based wastewater treatment

    Science.gov (United States)

    Markarian, R. K.; Balon, J. E.; Robinson, A. C.

    1977-01-01

    The status of activity in the user community for water hyacinth-based wastewater treatment was evaluated. The principal technique used was that of interviewing people who either (1) were known to be engaged in hyacinth research or development or (2) had made inquiry to NASA about hyacinth systems. About 40 non-research organizations and a similar number of research organizations were contacted. As a result of the interviews and a review of the relevant literature, it was concluded that hyacinth systems have the potential for providing a lower cost way for small cities to meet increasingly stringent effluent requirements. A limited amount of full-scale demonstration of hyacinth systems has been carried out during the past two years, but the yield of design data has been small. Several organizations are currently planning construction of experimental full-scale hyacinth-based wastewater treatment systems during 1977-1978.

  3. Attachment among older adults: current issues and directions for future research.

    Science.gov (United States)

    Bradley, J M; Cafferty, T P

    2001-09-01

    Although John Bowlby conceptualized attachment theory as applicable across the life span, researchers have been relatively slow to examine attachment phenomena specifically among older adults. The present article reviews the extant research applying attachment theory to older populations; preliminary findings suggest that attachment issues hold particular relevance for older adults, given the increased potential for separation, loss and vulnerability associated with aging. Although many of the studies reviewed are somewhat limited methodologically, the overall pattern of results suggests that attachment patterns are associated with a variety of outcomes in later life (such as adaptation to chronic illness and caregiver burden among family members, reactions to the death of a loved one, and general well-being) in a theoretically consistent manner. The implications of and questions raised by current findings are reviewed, and directions for future research are discussed.

  4. Unmanned aircraft systems in wildlife research: Current and future applications of a transformative technology

    Science.gov (United States)

    Christie, Katherine S.; Gilbert, Sophie L.; Brown, Casey L.; Hatfield, Michael; Hanson, Leanne

    2016-01-01

    Unmanned aircraft systems (UAS) – also called unmanned aerial vehicles (UAVs) or drones – are an emerging tool that may provide a safer, more cost-effective, and quieter alternative to traditional research methods. We review examples where UAS have been used to document wildlife abundance, behavior, and habitat, and illustrate the strengths and weaknesses of this technology with two case studies. We summarize research on behavioral responses of wildlife to UAS, and discuss the need to understand how recreational and commercial applications of this technology could disturb certain species. Currently, the widespread implementation of UAS by scientists is limited by flight range, regulatory frameworks, and a lack of validation. UAS are most effective when used to examine smaller areas close to their launch sites, whereas manned aircraft are recommended for surveying greater distances. The growing demand for UAS in research and industry is driving rapid regulatory and technological progress, which in turn will make them more accessible and effective as analytical tools.

  5. Qualitative ergonomics/human factors research in health care: Current state and future directions.

    Science.gov (United States)

    Valdez, Rupa Sheth; McGuire, Kerry Margaret; Rivera, A Joy

    2017-07-01

    The objective of this systematic review was to understand the current state of Ergonomics/Human Factors (E/HF) qualitative research in health care and to draw implications for future efforts. This systematic review identified 98 qualitative research papers published between January 2005 and August 2015 in the seven journals endorsed by the International Ergonomics Association with an impact factor over 1.0. The majority of the studies were conducted in hospitals and outpatient clinics, were focused on the work of formal health care professionals, and were classified as cognitive or organizational ergonomics. Interviews, focus groups, and observations were the most prevalent forms of data collection. Triangulation and data archiving were the dominant approaches to ensuring rigor. Few studies employed a formal approach to qualitative inquiry. Significant opportunities remain to enhance the use of qualitative research to advance systems thinking within health care. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. National and International Migration:Reflections on Literature and Some Current Research1

    Institute of Scientific and Technical Information of China (English)

    Nicholas Tapp(Wang Fuwen)

    2013-01-01

    This article gives a review on literature and some current research relevant to na-tional and international migration , and examines the connections between such research in a na-tional context , and the research on international migration .The approaches to migration in migra-tion studies are very complex , and the author suggested that we need to pay attention to all three approaches contrasted by Solinger:the one based on rational calculation , the one based on stress-ing the historico-structural conditions and the one based on social networking analysis .The au-thor also stresses the importance of a network approach taken from the sociology of John Urry in the studies of both national and international migration , and the need to see movement as prima-ry, and productive of place , as much recent anthropological literature has stressed .

  7. Pharmacotherapy for the core symptoms in autistic disorder: current status of the research.

    Science.gov (United States)

    Farmer, Cristan; Thurm, Audrey; Grant, Paul

    2013-03-01

    The current review covers extant literature on pharmacotherapy for core symptoms of autism. The core symptoms of autism include impairments in social interaction and communication, as well as the presence of restricted and repetitive behaviors. There are no known efficacious treatments for the core social symptoms, although effects on repetitive behaviors are indicated with some data. While studies of fenfluramine, secretin, opiates, and mood stabilizers generally find no effect, mixed results suggest more research is needed on antidepressants and atypical antipsychotics. Newer lines of research, including cholinergic and glutamatergic agents and oxytocin, will be of considerable interest in the future. However, research on the treatment of core symptoms is plagued by limitations in study design, statistical power, and other issues inherent to the study of treatments for autism (e.g., heterogeneity of the disorder) that continue to prevent the elucidation of efficacious treatments.

  8. Current status of production and research of radioisotopes and radiopharmaceuticals in Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    Soenarjo, Sunarhadijoso; Tamat, Swasono R. [Center for Development of Radioisotopes and Radiopharmaceuticals, National Nuclear Energy Agency (BATAN), Kawasan Puspiptek, Serpong, Tangerang (Indonesia)

    2000-10-01

    The use of radioactive preparation in Indonesia has sharply increased during the past years, indicated by increase of the number of companies utilizing radioisotopes during 1985 to 1999. It has been clearly stressed in the BATAN's Strategic Plan for 1994-2014 that the production of radioisotopes and radiopharmaceuticals is one of five main industrial fields within the platform of the Indonesian nuclear industry. Research programs supporting the production of radioisotopes and radiopharmaceuticals as well as development of production technology are undertaken by the Research Center for Nuclear Techniques (RCNT) in Bandung and by the Radioisotope Production Center (RPC) in Serpong, involving cooperation with other research center within BATAN, universities and hospitals as well as overseas nuclear research institution. The presented paper describes production and research status of radioisotopes and radiopharmaceuticals in Indonesia after the establishment of P.T. Batan Teknologi in 1996, a government company assigned for activities related to the commercial application of nuclear technology. The reviewed status is divided into two short periods, i.e. before and after the Chairman Decree No. 73/KA/IV/1999 declaring new BATAN organizational structure. Subsequent to the Decree, all commercial requests for radioisotopes and radiopharmaceuticals are fulfilled by P.T. Batan Teknologi, while demands on novel radioactive preparations or new processing technology, as well as research and development activities should be fulfilled by the Center for the Development of Radioisotopes and Radiopharmaceuticals (CDRR) through non-commercial arrangement. The near-future strategic research programs to response to dynamic public demand are also discussed. The status of research cooperation with JAERI (Japan) is also reported. (author)

  9. Constructed wetlands, 1991-2011: a review of research development, current trends, and future directions.

    Science.gov (United States)

    Zhi, Wei; Ji, Guodong

    2012-12-15

    This study explores a bibliometric approach to quantitatively evaluate global scientific constructed wetlands research, and statistically assess current trends, and future directions using the Science Citation Index Expanded (SCI-EXPANDED) database from 1991 to 2011. Articles referencing constructed wetlands were analyzed by accessing the following: publication language, output characteristics, publication performance by country and institution, author keywords, title words, and KeyWords Plus. Synthetically analyzing three keyword types, we concluded that the dominant constructed wetlands research hotspots from 1991 to 2011 included water, nutrients, plants, and flow. These four hotspots remained the most dominant research areas throughout our study period, and are predicted to remain the top research emphases in the near future. "Soil" also exhibited a notable increase since 2005, and is likely to become another notable area of research interest in the future. "Phytoremediation" and "horizontal" were not identified in 1991-1995, but exhibited marked increases from 136th (0.5%) and 169th (0.7%) in 1996-2000, to 9th (3.8%) and 11th (4.3%) in 2006-2011, respectively. Therefore, given the heightened attention during the last 15 years, these topics are likely to become a primary research focus in upcoming years.

  10. Targeting breast cancer through its microenvironment: current status of preclinical and clinical research in finding relevant targets.

    Science.gov (United States)

    Nienhuis, H H; Gaykema, S B M; Timmer-Bosscha, H; Jalving, M; Brouwers, A H; Lub-de Hooge, M N; van der Vegt, B; Overmoyer, B; de Vries, E G E; Schröder, C P

    2015-03-01

    It is increasingly evident that not only breast cancer cells, but also the tissue embedding these cells: the tumor microenvironment, plays an important role in tumor progression, metastasis formation and treatment sensitivity. This review focuses on the current knowledge of processes by which the microenvironment affects breast cancer, including formation of the metastatic niche, metabolic stimulation, stimulation of tumor cell migration, immune modulation, angiogenesis and matrix remodeling. The number of drugs targeting key factors in these processes is expanding, and the available clinical data is increasing. Therefore current strategies for intervention and prediction of treatment response are outlined. At present, targeting the formation of the metastatic niche and metabolic stimulation by the breast cancer microenvironment, are already showing clinical efficacy. Intervening in the stimulation of tumor cell migration and immune modulation by the microenvironment upcoming fields of great research interest. In contrast, targeting microenvironmental angiogenesis or matrix remodeling appears to be of limited clinical relevance in breast cancer treatment so far. Further research is warranted to optimize intervention strategies and develop predictive tests for the relevance of targeting involved factors within the microenvironment in order to optimally personalize breast cancer treatment. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Consolidated academic and research exposition: a pilot study of an innovative education method to increase residents' research involvement.

    Science.gov (United States)

    Basu Ray, Indranill; Henry, Tracey L; Davis, William; Alam, Jawed; Amedee, Ronald G; Pinsky, William W

    2012-01-01

    Internal medicine residents at the Ochsner Clinic Foundation stay engaged with clinical work and have difficulty initiating and completing research and publishing their scholarly activities. Commonly cited barriers include lack of knowledge about institutional research programs, lack of confidence regarding medical writing skills, lack of time, and failure to understand the value of research. The residency directors at Ochsner initiated the Consolidated Academic and Research Exposition (CARE) program to teach basic research skills and encourage residents' interest and productivity in research. The CARE program includes 4 core components: house staff mentoring and the Resident Career Development Program, a journal club, medical writing instruction, and research engagement. Particular emphasis is given to projects that could be completed within a 1-month period and result in publication, enabling residents to use a 1-month elective rotation during their first postgraduate year. The sessions are mandatory for residents, except for those on specified rotations, including the critical care service and the night float rotation and those who are postcall. In 2010-2011, 6 residents submitted abstracts to the Louisiana Chapter of the American College of Physicians Associates meeting; 2 abstracts were accepted for presentation. In 2011-2012, there were 14 submissions, 4 of which were accepted for presentation. In 2010-2011, there were 4 submissions to the Southern Hospitalist Conference, which increased to 7 submissions in 2011-2012. The second best presentation award at the Southern Hospitalist Conference was also earned by a resident of this institution. The program saw a 110% total increase in scholarly activity from 2010-2011 to 2011-2012. The CARE program has been in existence for approximately 1 year. Preliminary results were tabulated based on research proposals, posters, abstracts, case reports, and presentations submitted and/or accepted at leading medical

  12. The required interactions among institutions involved with Research and Development in the power sector

    Energy Technology Data Exchange (ETDEWEB)

    Vieira Filho, X.; Medeiros, J.C.; Szechtman, M. [Centro de Pesquisas de Energia Eletrica (CEPEL), Rio de Janeiro, RJ (Brazil)

    1994-12-31

    This paper presents the form which CEPEL (Brazilian Federal Research Center in Electric Energy) works for the Brazilian electric system, the interaction with associates, especially with ELETROBRAS (the Federal holding company in Brazil), the modern way of CEPEL operation and interactions with clients, the partnership in Research and Development, the CEPEL philosophy of transferring technology to its clients, and the cost-benefit analysis of Research and Development activities. (author) 2 refs., 4 figs., 1 tab.

  13. A critical analysis of the implementation of service user involvement in primary care research and health service development using normalization process theory.

    Science.gov (United States)

    Tierney, Edel; McEvoy, Rachel; O'Reilly-de Brún, Mary; de Brún, Tomas; Okonkwo, Ekaterina; Rooney, Michelle; Dowrick, Chris; Rogers, Anne; MacFarlane, Anne

    2016-06-01

    There have been recent important advances in conceptualizing and operationalizing involvement in health research and health-care service development. However, problems persist in the field that impact on the scope for meaningful involvement to become a routine - normalized - way of working in primary care. In this review, we focus on current practice to critically interrogate factors known to be relevant for normalization - definition, enrolment, enactment and appraisal. Ours was a multidisciplinary, interagency team, with community representation. We searched EBSCO host for papers from 2007 to 2011 and engaged in an iterative, reflexive approach to sampling, appraising and analysing the literature following the principles of a critical interpretive synthesis approach and using Normalization Process Theory. Twenty-six papers were chosen from 289 papers, as a purposeful sample of work that is reported as service user involvement in the field. Few papers provided a clear working definition of service user involvement. The dominant identified rationale for enrolling service users in primary care projects was linked with policy imperatives for co-governance and emancipatory ideals. The majority of methodologies employed were standard health services research methods that do not qualify as research with service users. This indicates a lack of congruence between the stated aims and methods. Most studies only reported positive outcomes, raising questions about the balance or completeness of the published appraisals. To improve normalization of meaningful involvement in primary care, it is necessary to encourage explicit reporting of definitions, methodological innovation to enhance co-governance and dissemination of research processes and findings. © 2014 The Authors Health Expectations Published by John Wiley & Sons Ltd.

  14. Building, Engaging, and Supporting Family and Parental Involvement in Out-of-School Time Programs. Research-to-Results Brief. Publication #2007-16

    Science.gov (United States)

    Horowitz, Allison; Bronte-Tinkew, Jacinta

    2007-01-01

    Research has long shown that parents' positive involvement with their children's schooling is related to many positive outcomes. However, less research has been done on the involvement of parents and families in out-of-school time programs. Nevertheless, the research that does exist suggests that family involvement can be an important component of…

  15. [Current situation on fertility preservation in cancer patients in Spain: Level of knowledge, information, and professional involvement].

    Science.gov (United States)

    Garrido-Colino, Carmen; Lassaletta, Alvaro; Vazquez, María Ángeles; Echevarria, Aizpea; Gutierrez, Ignacio; Andión, Maitane; Berlanga, Pablo

    2017-07-01

    The estimated risks of infertility in childhood cancer due to radiation, chemotherapy and surgery are well known. The involvement of professionals and advances in the different methods of preservation are increasing. However, many patients do not receive information or perform any method of preservation. Questionnaires to paediatric onco-haematology institutions throughout Spain. The questionnaire consisted of 22 questions assessing their usual practices and knowledge about fertility preservation. Fifty members of the Spanish Society of Paediatric Haematology and Oncology, representing 24 of 43 centres, responded. These represented 82% of centres that treated higher numbers of patients. The effect of treatment on fertility was known by 78% of those who responded, with 76% admitting not knowing any guideline on fertility in children or adolescents. As for the ideal time and place to inform the patient and/or family, only 14% thought it should be done in the same cancer diagnosis interview. In clinical practice, 12% of those surveyed never referred patients to Human Reproduction Units, another 12% only did so if the patients showed interest, and 38% only refer patients in puberty. Just over one-third (34%) of those referrals were going to receive highly gonadotoxic treatment. There are clear differences between pre-puberty and puberty patients. The frequency with which some method of fertility preservation is performed in patients is low. All respondents believe that the existence of national guidelines on the matter would be of interest. Copyright © 2016 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. An Official American Thoracic Society Research Statement: Current Challenges Facing Research and Therapeutic Advances in Airway Remodeling.

    Science.gov (United States)

    Prakash, Y S; Halayko, Andrew J; Gosens, Reinoud; Panettieri, Reynold A; Camoretti-Mercado, Blanca; Penn, Raymond B

    2017-01-15

    Airway remodeling (AR) is a prominent feature of asthma and other obstructive lung diseases that is minimally affected by current treatments. The goals of this Official American Thoracic Society (ATS) Research Statement are to discuss the scientific, technological, economic, and regulatory issues that deter progress of AR research and development of therapeutics targeting AR and to propose approaches and solutions to these specific problems. This Statement is not intended to provide clinical practice recommendations on any disease in which AR is observed and/or plays a role. An international multidisciplinary group from within academia, industry, and the National Institutes of Health, with expertise in multimodal approaches to the study of airway structure and function, pulmonary research and clinical practice in obstructive lung disease, and drug discovery platforms was invited to participate in one internet-based and one face-to-face meeting to address the above-stated goals. Although the majority of the analysis related to AR was in asthma, AR in other diseases was also discussed and considered in the recommendations. A literature search of PubMed was performed to support conclusions. The search was not a systematic review of the evidence. Multiple conceptual, logistical, economic, and regulatory deterrents were identified that limit the performance of AR research and impede accelerated, intensive development of AR-focused therapeutics. Complementary solutions that leverage expertise of academia and industry were proposed to address them. To date, numerous factors related to the intrinsic difficulty in performing AR research, and economic forces that are disincentives for the pursuit of AR treatments, have thwarted the ability to understand AR pathology and mechanisms and to address it clinically. This ATS Research Statement identifies potential solutions for each of these factors and emphasizes the importance of educating the global research community as to the

  17. The Evaluation of Scholarly Books as Research Output. Current Developments in Europe

    DEFF Research Database (Denmark)

    Giminez-Toledo, Elea; Mañana-Rodriguez, Jorge; Engels, Tim

    2015-01-01

    and information needed for the assessment of this type of publication has urged several European countries to develop custom-built information systems for the registration of books, weighting procedures and funding allocation practices enabling a proper assessment of books and book-type publications....... For the first time, these systems make the assessment of books as a research output feasible. This paper resumes the main features of the assessment systems developed in five European countries / regions (Spain, Denmark, Flanders, Finland and Norway), focusing on the processes involved in the collection...

  18. Integrated assessment and management of ambient particulate matter: International perspective and current research in Serbia

    Directory of Open Access Journals (Sweden)

    Bartonova Alena

    2012-01-01

    Full Text Available Air pollution mitigation is a necessity in Serbia, due to its high levels of criteria pollutants in ambient environment. Successful implementation of mitigation measures requires access to sufficient information from national research, and well running and efficient local participatory processes. To support air pollution mitigation in the West Balkan region, the WeBIOPATR project started a series of bi-annual conferences in 2007. They bring together an inter-disciplinary research community and local and national administrations from Serbia and its neighborhood, to present research results from Serbia and countries all over the world, and to share knowledge and best practices of mitigation. The conferences promote research that may support integrated assessment of particulate matter, and further refinement of the “Pressures-State-Impact“ (PSI part of the “Drivers-Pressures-State-Impact-Response“ (DPSIR framework. Integrated approach needs to be underpinned by solid disciplinary research covering e.g. air quality monitoring technologies, atmospheric and further ambient composition, atmospheric modeling, biological effects and human health. WeBIOPATR conferences report on recently performed studies of particulate matter in Serbia and abroad. Through the breadth of subjects and audience, they bring together a wide inter-disciplinary and cross-sectoral expertise in support of translation of research to practice. They also allow to present examples of successful mitigation achieved with the help of strong local participatory environmental governance, demonstrating the increasing recognition of the need to involve both public and private actors. This paper gives the main features of a full chain approach and elements of integrated approach to particulate matter research, summarizes the proceedings of the 3rd WeBIOPATR conference, and in addition, reviews the results of particulate matter monitoring and source identification studies in Serbia

  19. 48 CFR 1352.235-73 - Research involving human subjects-after initial contract award.

    Science.gov (United States)

    2010-10-01

    ... women, prisoners, or children, the contractor is also required to follow the guidelines set forth at 45... documentation may include: (1) Copies of the human subjects research protocol, advertisements, recruitment... human subjects research protocol, advertisements, recruitment material, and informed consent forms...

  20. Involvement of serum HSP 70 in Guillain-Barré Syndrome: An exploratory study and a review of current literature

    Directory of Open Access Journals (Sweden)

    Aida Loshaj-Shala

    2015-01-01

    Full Text Available The evolutionary conserved family of heat shock proteins (HSP is responsible for protecting cells against different types of stress. Although the levels of HSP can be readily measured in serum, the levels of HSP 70 in patients Guillain-Barre Syndrome (GBS have not been studied before. To this aim we investigate whether patients with GBS (n=21 had altered serum HSP 70 levels compared to healthy controls (HC, n=9 and to patients affected by other immune disorders such as multifocal motor neuropathy (MMN, n=4 and chronic inflammatory demyelinating polyneuropathy (CIDP, n=6. The highest HSP 70 value (15.78 ± 1.72 ng/mL was found in one patient in the GBS group, although we have found that serum HSP70 levels were significantly higher in 2 out of the 21 GBS patients (9.5%. Hence, it is of interest to underline that the patient with the highest HSP70 level, had also the best recovery rate. Моrе extensive research is required in order to support the hypothesis that HSP 70 serum concentration may be a useful biomarker for the prediction of remission outcome for GBS patients.

  1. Setting health research priorities using the CHNRI method: III. Involving stakeholders

    Directory of Open Access Journals (Sweden)

    Sachiyo Yoshida

    2016-06-01

    Full Text Available Setting health research priorities is a complex and value–driven process. The introduction of the Child Health and Nutrition Research Initiative (CHNRI method has made the process of setting research priorities more transparent and inclusive, but much of the process remains in the hands of funders and researchers, as described in the previous two papers in this series. However, the value systems of numerous other important stakeholders, particularly those on the receiving end of health research products, are very rarely addressed in any process of priority setting. Inclusion of a larger and more diverse group of stakeholders in the process would result in a better reflection of the system of values of the broader community, resulting in recommendations that are more legitimate and acceptable.

  2. From plans to actions in patient and public involvement: qualitative study of documented plans and the accounts of researchers and patients sampled from a cohort of clinical trials.

    Science.gov (United States)

    Buck, Deborah; Gamble, Carrol; Dudley, Louise; Preston, Jennifer; Hanley, Bec; Williamson, Paula R; Young, Bridget

    2014-12-04

    : Patient and public involvement (PPI) in research is increasingly required, although evidence to inform its implementation is limited. Inform the evidence base by describing how plans for PPI were implemented within clinical trials and identifying the challenges and lessons learnt by research teams. We compared PPI plans extracted from clinical trial grant applications (funded by the National Institute for Health Research Health Technology Assessment Programme between 2006 and 2010) with researchers' and PPI contributors' interview accounts of PPI implementation. Analysis of PPI plans and transcribed qualitative interviews drew on the Framework technique. Of 28 trials, 25 documented plans for PPI in funding applications and half described implementing PPI before applying for funding. Plans varied from minimal to extensive, although almost all anticipated multiple modes of PPI. Interview accounts indicated that PPI plans had been fully implemented in 20/25 trials and even expanded in some. Nevertheless, some researchers described PPI within their trials as tokenistic. Researchers and contributors noted that late or minimal PPI engagement diminished its value. Both groups perceived uncertainty about roles in relation to PPI, and noted contributors' lack of confidence and difficulties attending meetings. PPI contributors experienced problems in interacting with researchers and understanding technical language. Researchers reported difficulties finding 'the right' PPI contributors, and advised caution when involving investigators' current patients. Engaging PPI contributors early and ensuring ongoing clarity about their activities, roles and goals, is crucial to PPI's success. Funders, reviewers and regulators should recognise the value of preapplication PPI and allocate further resources to it. They should also consider whether PPI plans in grant applications match a trial's distinct needs. Monitoring and reporting PPI before, during and after trials will help the

  3. Reflections on the United States National Institutes of Health draft guidelines for research involving human pluripotent stem cells--theological perspective.

    Science.gov (United States)

    Sotis, J J

    2000-01-01

    Since the human embryonic stem cell research involves destruction of human embryos and, therefore, hinges on the fundamental question of the status of the embryo, it is essential to examine this status carefully in order to establish fitting guidelines for research. The US National Institutes of Health has proposed its own guidelines on the matter recently (1999). The document, rooted in current pluralistic perspectives in moral philosophy (or bioethics), is criticised in this paper as morally inadequate. The argumentation of the criticism stems from the theological perspective on human personhood, which focuses on a continuity of personal identity from embryos to adult human beings. An additional concern for the author is the moral complicity in which the research dependent upon the destruction of human embryonic life is sanctioned.

  4. Informed Consent and Clinical Research Involving Children and Adolescents: Implications of the Revised APA Ethics Code and HIPAA

    Science.gov (United States)

    Fisher, Celia B.

    2004-01-01

    In 2003, 2 new sets of rules and regulations affecting the conduct of clinical research involving children and adolescents went into effect: the revised American Psychological Association's (APA) Ethical Principles of Psychologists and Code of Conduct (APA, 2002; effective June 1, 2003) and the Privacy Rule (45 CFR Part 160 and A and E of Part…

  5. The Need to Distinguish between Quantity and Quality in Research on Parental Involvement: The Example of Parental Help with Homework

    Science.gov (United States)

    Moroni, Sandra; Dumont, Hanna; Trautwein, Ulrich; Niggli, Alois; Baeriswyl, Franz

    2015-01-01

    Parental involvement research has greatly expanded over the past decade, but findings are mixed, reflecting in part the conceptual and methodological limitations of many studies. On the basis of longitudinal questionnaire data from 1,685 sixth-grade students, the authors studied parental help with homework because it is the most common and most…

  6. 40 CFR 26.1203 - Prohibition of research involving intentional exposure of any human subject who is a pregnant...

    Science.gov (United States)

    2010-07-01

    ... intentional exposure of any human subject who is a pregnant woman (and therefore her fetus), a nursing woman... Exposure of Human Subjects who are Children or Pregnant or Nursing Women § 26.1203 Prohibition of research involving intentional exposure of any human subject who is a pregnant woman (and therefore her fetus),...

  7. 45 CFR 46.203 - Duties of IRBs in connection with research involving pregnant women, fetuses, and neonates.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Duties of IRBs in connection with research involving pregnant women, fetuses, and neonates. 46.203 Section 46.203 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Additional Protections for Pregnant Women, Human Fetuses and Neonates...

  8. The Need to Distinguish between Quantity and Quality in Research on Parental Involvement: The Example of Parental Help with Homework

    Science.gov (United States)

    Moroni, Sandra; Dumont, Hanna; Trautwein, Ulrich; Niggli, Alois; Baeriswyl, Franz

    2015-01-01

    Parental involvement research has greatly expanded over the past decade, but findings are mixed, reflecting in part the conceptual and methodological limitations of many studies. On the basis of longitudinal questionnaire data from 1,685 sixth-grade students, the authors studied parental help with homework because it is the most common and most…

  9. 34 CFR 97.406 - Research involving greater than minimal risk and no prospect of direct benefit to individual...

    Science.gov (United States)

    2010-07-01

    ... prospect of direct benefit to individual subjects, but likely to yield generalizable knowledge about the... § 97.406 Research involving greater than minimal risk and no prospect of direct benefit to individual... an intervention or procedure that does not hold out the prospect of direct benefit for the...

  10. Using ASM Podcasts to Excite Undergraduate Students about Current Microbiological Research

    Directory of Open Access Journals (Sweden)

    Stacey E. Lettini

    2014-08-01

    Full Text Available Innovative technology is often used as a mechanism to engage students in and out of the classroom and can be used to increase critical thinking skills. Podcasts are an excellent way to introduce students to current topics and research in microbiology. The American Society for Microbiology (ASM produces three podcasts that are microbiologically focused: This Week in Microbiology (TWiM, This Week in Parasitology (TWiP, and This Week in Virology (TWiV. These podcasts are usually presented in a manner similar to a journal club, as the presenters regularly invite guests to discuss current research papers. Since students often find reading scientific literature difficult and get bogged down in the details rather than seeing the over-arching purpose of a paper, these podcasts have been used in a General Microbiology course to introduce recent research articles. The students were first assigned an original research article to read and review, and they were asked to generate questions pertaining to things they did not understand. Next, students listened to the corresponding podcast that discussed the article and used it to answer their questions. This was followed by a classroom discussion of the article and the podcast. The ASM podcast helped to demystify original research by providing details of the experimental design and presentation of the results in a language that is more casual and relatable. Students demonstrated greater critical thinking and comprehension of microbiology literature after listening to the podcast. This activity can be used in a variety of courses in the biology curriculum.

  11. Current research and potential applications of the Concealed Information Test: An overview

    Directory of Open Access Journals (Sweden)

    Gershon eBen-Shakhar

    2012-09-01

    Full Text Available Research interest in psychophysiological detection of deception has significantly increased since the September 11 terror attack in the USA. In particular, the Concealed Information Test (CIT, designed to detect memory traces that can connect suspects to a certain crime, has been extensively studied. In this paper I will briefly review several psychophysiological detection paradigms that have been studied, with a focus on the CIT. The theoretical background of the CIT, its strength and weaknesses, its potential applications as well as research finings related to its validity, (based on a recent mata-analytic study, will be discussed. Several novel research directions, with a focus on factors that may affect CIT detection in realistic settings (e.g., memory for crime details; the effect of emotional stress during crime execution will be described. Additionally, research focusing on mal-intentions and attempts to detect terror networks using information gathered from groups of suspects using both the standard CIT and the searching CIT will be reviewed. Finally, implications of current research to the actual application of the CIT will be discussed and several recommendations that can enhance the use of the CIT will be made.

  12. Prebiotics and the health benefits of fiber: current regulatory status, future research, and goals.

    Science.gov (United States)

    Brownawell, Amy M; Caers, Wim; Gibson, Glenn R; Kendall, Cyril W C; Lewis, Kara D; Ringel, Yehuda; Slavin, Joanne L

    2012-05-01

    First defined in the mid-1990s, prebiotics, which alter the composition and activity of gastrointestinal (GI) microbiota to improve health and well-being, have generated scientific and consumer interest and regulatory debate. The Life Sciences Research Organization, Inc. (LSRO) held a workshop, Prebiotics and the Health Benefits of Fiber: Future Research and Goals, in February 2011 to assess the current state of the science and the international regulatory environment for prebiotics, identify research gaps, and create a strategy for future research. A developing body of evidence supports a role for prebiotics in reducing the risk and severity of GI infection and inflammation, including diarrhea, inflammatory bowel disease, and ulcerative colitis as well as bowel function disorders, including irritable bowel syndrome. Prebiotics also increase the bioavailability and uptake of minerals and data suggest that they reduce the risk of obesity by promoting satiety and weight loss. Additional research is needed to define the relationship between the consumption of different prebiotics and improvement of human health. New information derived from the characterization of the composition and function of different prebiotics as well as the interactions among and between gut microbiota and the human host would improve our understanding of the effects of prebiotics on health and disease and could assist in surmounting regulatory issues related to prebiotic use.

  13. Current Realities and Future Possibilities: Language and science literacy—empowering research and informing instruction

    Science.gov (United States)

    Yore, Larry D.; Treagust, David F.

    2006-02-01

    In this final article, we briefly review and synthesize the science and language research and practice that arose from the current literature and presentations at an international conference, referred to as the first “Island Conference”. We add to the synthesis of the articles the conference deliberations and on-going discussions of the field and also offer our views as to how such contributions can take place. These central issues—the definition of science literacy; the models of learning, discourse, reading, and writing and their underlying pedagogical assumptions; the roles of discourse in doing, teaching, and learning science; and the demands on teacher education and professional development in the current reforms in language and science education—provide points of departure for discussion of four possible new considerations to research in this field of endeavour that could contribute to a broader and productive scholarship and deeper and enriched understanding of both teaching and learning. These considerations, each from well-established fields of research literature, are the need to develop support for a contemporary view of science literacy, the role of metacognition in science learning generally, the role of multiple representations in knowledge building and science literacy, and the need for more focused teacher education and professional development programmes.

  14. A comparative study: the impact of different lipid extraction methods on current microalgal lipid research.

    Science.gov (United States)

    Li, Yan; Ghasemi Naghdi, Forough; Garg, Sourabh; Adarme-Vega, Tania Catalina; Thurecht, Kristofer J; Ghafor, Wael Abdul; Tannock, Simon; Schenk, Peer M

    2014-01-24

    Microalgae cells have the potential to rapidly accumulate lipids, such as triacylglycerides that contain fatty acids important for high value fatty acids (e.g., EPA and DHA) and/or biodiesel production. However, lipid extraction methods for microalgae cells are not well established, and there is currently no standard extraction method for the determination of the fatty acid content of microalgae. This has caused a few problems in microlagal biofuel research due to the bias derived from different extraction methods. Therefore, this study used several extraction methods for fatty acid analysis on marine microalga Tetraselmis sp. M8, aiming to assess the potential impact of different extractions on current microalgal lipid research. These methods included classical Bligh & Dyer lipid extraction, two other chemical extractions using different solvents and sonication, direct saponification and supercritical CO₂ extraction. Soxhlet-based extraction was used to weigh out the importance of solvent polarity in the algal oil extraction. Coupled with GC/MS, a Thermogravimetric Analyser was used to improve the quantification of microalgal lipid extractions. Among these extractions, significant differences were observed in both, extract yield and fatty acid composition. The supercritical extraction technique stood out most for effective extraction of microalgal lipids, especially for long chain unsaturated fatty acids. The results highlight the necessity for comparative analyses of microalgae fatty acids and careful choice and validation of analytical methodology in microalgal lipid research.

  15. Radiology Research in Quality and Safety: Current Trends and Future Needs.

    Science.gov (United States)

    Zygmont, Matthew E; Itri, Jason N; Rosenkrantz, Andrew B; Duong, Phuong-Anh T; Mankowski Gettle, Lori; Mendiratta-Lala, Mishal; Scali, Elena P; Winokur, Ronald S; Probyn, Linda; Kung, Justin W; Bakow, Eric; Kadom, Nadja

    2017-03-01

    Promoting quality and safety research is now essential for radiology as reimbursement is increasingly tied to measures of quality, patient safety, efficiency, and appropriateness of imaging. This article provides an overview of key features necessary to promote successful quality improvement efforts in radiology. Emphasis is given to current trends and future opportunities for directing research. Establishing and maintaining a culture of safety is paramount to organizations wishing to improve patient care. The correct culture must be in place to support quality initiatives and create accountability for patient care. Focused educational curricula are necessary to teach quality and safety-related skills and behaviors to trainees, staff members, and physicians. The increasingly complex healthcare landscape requires that organizations build effective data infrastructures to support quality and safety research. Incident reporting systems designed specifically for medical imaging will benefit quality improvement initiatives by identifying and learning from system errors, enhancing knowledge about safety, and creating safer systems through the implementation of standardized practices and standards. Finally, validated performance measures must be developed to accurately reflect the value of the care we provide for our patients and referring providers. Common metrics used in radiology are reviewed with focus on current and future opportunities for investigation. Copyright © 2017 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  16. Using Technology to Enhance Research-Based Best Practices for Increasing Parental Involvement: A Case Study

    Science.gov (United States)

    Helgesen, Rhonda L.

    2012-01-01

    The No Child Left Behind Act of 2001 (NCLB) established guidelines pertaining to student achievement and included requirements regarding parental involvement and communication between the school and home. Various issues stand in the way of realizing the level of parental engagement desired by educators and ordered by NCLB. Parental participation…

  17. An Example of Discovery Research Involving the Transfer of Stimulus Control

    Science.gov (United States)

    Tiger, Jeffrey H.; Hanley, Gregory P.

    2005-01-01

    The initial purpose of the present study was to replicate procedures for teaching preschool children to recruit attention at appropriate times by having an experimenter signal the availability and unavailability of attention (i.e., arrange a multiple schedule involving reinforcement and extinction; Tiger & Hanley, 2004). Following the development…

  18. Consumer Involvement in Rehabilitation Research & Practice: Institute on Rehabilitation Issues (19th).

    Science.gov (United States)

    Arkansas Univ., Fayetteville. Research and Training Center in Vocational Rehabilitation.

    This document was prepared in response to the 1992 Rehabilitation Act Amendments (P.L. 102-569), which provide a legal basis for greater consumer involvement in rehabilitation services. The focus of this document is to: (1) show how persons with disabilities can better participate in their rehabilitation programs; (2) lay the foundation for…

  19. Parent Involvement in the College Recruiting Process: To What Extent? CERI Research Brief 2-2007

    Science.gov (United States)

    Gardner, Phil

    2010-01-01

    Parents' increasing involvement in their children's transition from college to work has grabbed the attention of the media. Every time the author talks with employer groups, he hears similar stories about the pervasive presence of parents in the recruiting process. At the same time, numerous employers questioned the presence of parents in the…

  20. Towards Current Profile Control in ITER: Potential Approaches and Research Needs

    Science.gov (United States)

    Schuster, E.; Barton, J. E.; Wehner, W. P.

    2014-10-01

    Many challenging plasma control problems still need to be addressed in order for the ITER Plasma Control System (PCS) to be able to successfully achieve the ITER project goals. For instance, setting up a suitable toroidal current density profile is key for one possible advanced scenario characterized by noninductive sustainment of the plasma current and steady-state operation. The nonlinearity and high dimensionality exhibited by the plasma demand a model-based current-profile control synthesis procedure that can accommodate this complexity through embedding the known physics within the design. The development of a model capturing the dynamics of the plasma relevant for control design enables not only the design of feedback controllers for regulation or tracking but also the design of optimal feedforward controllers for a systematic model-based approach to scenario planning, the design of state estimators for a reliable real-time reconstruction of the plasma internal profiles based on limited and noisy diagnostics, and the development of a fast predictive simulation code for closed-loop performance evaluation before implementation. Progress towards control-oriented modeling of the current profile evolution and associated control design has been reported following both data-driven and first-principles-driven approaches. An overview of these two approaches will be provided, as well as a discussion on research needs associated with each one of the model applications described above. Supported by the US Department of Energy under DE-SC0001334 and DE-SC0010661.