WorldWideScience

Sample records for current regulatory regime

  1. European gas market liberalisation: are regulatory regimes moving towards convergence?

    NARCIS (Netherlands)

    Haase, N.

    2008-01-01

    This study has assessed the evolution of regulatory regimes in European gas markets on the basis of panel data from the old member states (EU15) for the period between 2000 and 2005. The methodology used enabled us to assess whether regulatory regimes are converging. In this context, an index has

  2. Fisheries regulatory regimes and resilience to climate change.

    Science.gov (United States)

    Ojea, Elena; Pearlman, Isaac; Gaines, Steven D; Lester, Sarah E

    2017-05-01

    Climate change is already producing ecological, social, and economic impacts on fisheries, and these effects are expected to increase in frequency and magnitude in the future. Fisheries governance and regulations can alter socio-ecological resilience to climate change impacts via harvest control rules and incentives driving fisher behavior, yet there are no syntheses or conceptual frameworks for examining how institutions and their regulatory approaches can alter fisheries resilience to climate change. We identify nine key climate resilience criteria for fisheries socio-ecological systems (SES), defining resilience as the ability of the coupled system of interacting social and ecological components (i.e., the SES) to absorb change while avoiding transformation into a different undesirable state. We then evaluate the capacity of four fisheries regulatory systems that vary in their degree of property rights, including open access, limited entry, and two types of rights-based management, to increase or inhibit resilience. Our exploratory assessment of evidence in the literature suggests that these regulatory regimes vary widely in their ability to promote resilient fisheries, with rights-based approaches appearing to offer more resilience benefits in many cases, but detailed characteristics of the regulatory instruments are fundamental.

  3. Current Regulations and Regulatory Actions

    Science.gov (United States)

    This site will provide basic information on clean air permitting under the title V operating permits program, provide access to state and regional permitting programs, and maintain access to proposed and final regulatory requirements.

  4. Twin-Peak Financial Regulatory Regime in China: A Desirability Analysis

    DEFF Research Database (Denmark)

    Hu, Chenchen

    2015-01-01

    speed of the expansion of shadow banking activities. The banking activity expansion and the emergence of financial conglomerates have been challenging the effectiveness of the current institutional regulatory structure: the fragmented "One Bank and Three Commissions" system and the "Joint Meeting...... as a "deep context". By drawing on the Australia experience of the twin-peak reform and discussing the new ecology of the Chinese financial markets, the article attempts to answer the question of the desirability of a twin-peak regulatory regime in China....

  5. Technical efficiency under alternative environmental regulatory regimes : The case of Dutch horticulture

    NARCIS (Netherlands)

    van der Vlist, Arno J.; Withagen, Cees; Folmer, Henk

    2007-01-01

    We consider the performance of small and medium sized enterprises in Dutch horticulture under different environmental policy regimes across time. We address the question whether technical performance differs under these alternative regulatory regimes to test Porter's hypothesis that stricter environ

  6. Technical efficiency under alternative environmental regulatory regimes: The case of Dutch horticulture

    NARCIS (Netherlands)

    Vlist, van der A.J.; Withagen, C.; Folmer, H.

    2007-01-01

    We consider the performance of small and medium sized enterprises in Dutch horticulture under different environmental policy regimes across time. We address the question whether technical performance differs under these alternative regulatory regimes to test Porter's hypothesis that stricter environ

  7. Sales Growth of New Pharmaceuticals Across the Globe: The Role of Regulatory Regimes

    NARCIS (Netherlands)

    S. Stremersch (Stefan); A. Lemmens (Aurélie)

    2008-01-01

    textabstractPrior marketing literature has overlooked the role of regulatory regimes in explaining international sales growth of new products. This paper addresses this gap in the context of new pharmaceuticals (15 new molecules in 34 countries) and sheds light on the effect regulatory regimes have

  8. Sales Growth of New Pharmaceuticals Across the Globe: The Role of Regulatory Regimes

    NARCIS (Netherlands)

    S. Stremersch (Stefan); A. Lemmens (Aurélie)

    2008-01-01

    textabstractPrior marketing literature has overlooked the role of regulatory regimes in explaining international sales growth of new products. This paper addresses this gap in the context of new pharmaceuticals (15 new molecules in 34 countries) and sheds light on the effect regulatory regimes have

  9. High current regimes in RFX-mod

    Science.gov (United States)

    Valisa, M.; Bolzonella, T.; Buratti, P.; Carraro, L.; Cavazzana, R.; Dal Bello, S.; Martin, P.; Pasqualotto, R.; Sarff, J. S.; Spolaore, M.; Zanca, P.; Zanotto, L.; Agostini, M.; Alfier, A.; Antoni, V.; Apolloni, L.; Auriemma, F.; Barana, O.; Baruzzo, M.; Bettini, P.; Bonfiglio, D.; Bonomo, F.; Brombin, M.; Buffa, A.; Canton, A.; Cappello, S.; Cavinato, M.; Chitarin, G.; DeLorenzi, A.; DeMasi, G.; Escande, D. F.; Fassina, A.; Franz, P.; Gaio, E.; Gazza, E.; Giudicotti, L.; Gnesotto, F.; Gobbin, M.; Grando, L.; Guazzotto, L.; Guo, S. C.; Igochine, V.; Innocente, P.; Lorenzini, R.; Luchetta, A.; Manduchi, G.; Marchiori, G.; Marcuzzi, D.; Marrelli, L.; Martini, S.; Martines, E.; McCollam, K.; Milani, F.; Moresco, M.; Novello, L.; Ortolani, S.; Paccagnella, R.; Peruzzo, S.; Piovan, R.; Piron, L.; Pizzimenti, A.; Piovesan, P.; Pomaro, N.; Predebon, I.; Puiatti, M. E.; Rostagni, G.; Sattin, F.; Scarin, P.; Serianni, G.; Sonato, P.; Spada, E.; Soppelsa, A.; Spagnolo, S.; Spizzo, G.; Taliercio, C.; Terranova, D.; Toigo, V.; Vianello, N.; Yadikin, D.; Zaccaria, P.; Zaniol, B.; Zilli, E.; Zuin, M.

    2008-12-01

    Optimization of machine operation, including plasma position control, density control and especially feedback control on multiple magnetohydrodynamic modes, has led RFX-mod to operate reliably at 1.5 MA, the highest current ever achieved on a reversed field pinch (RFP). At high current and low density the magnetic topology spontaneously self-organizes in an Ohmical helical symmetry, with the new magnetic axis helically twisting around the geometrical axis of the torus. The separatrix of the island disappears leaving a wide and symmetric thermal structure with large gradients in the electron temperature profile. The new topology still displays an intermittent nature but its overall presence has reached 85% of the current flat-top period. The large gradients in the electron temperature profile appear to be marginal for the destabilization of ion temperature gradient modes on the assumption that ions and electrons have the same gradients. There are indications that higher currents could provide the conditions under which to prove the existence of a true helical equilibrium as the standard RFP configuration.

  10. Overplanting in offshore wind power plants in different regulatory regimes

    DEFF Research Database (Denmark)

    Wolter, Christoph; Klinge Jacobsen, Henrik; Rogdakis, Georgios

    2016-01-01

    framework results more favourable to overplanting. The results indicate that current conceivable offshore wind power plants in the UK can increase their economic value by around 30 mio AC when optimising their capacity setup. In Denmark, current regulations are not suitable for overplanting causing loss...

  11. Biosafety, biosecurity and internationally mandated regulatory regimes: compliance mechanisms for education and global health security

    Science.gov (United States)

    Sture, Judi; Whitby, Simon; Perkins, Dana

    2015-01-01

    This paper highlights the biosafety and biosecurity training obligations that three international regulatory regimes place upon states parties. The duty to report upon the existence of such provisions as evidence of compliance is discussed in relation to each regime. We argue that such mechanisms can be regarded as building blocks for the development and delivery of complementary biosafety and biosecurity teaching and training materials. We show that such building blocks represent foundations upon which life and associated scientists – through greater awareness of biosecurity concerns – can better fulfil their responsibilities to guard their work from misuse in the future. PMID:24494580

  12. Impacts of different regulatory regimes in the unitization of production; Impactos dos diferentes regimes regulatorios na individualizacao da producao

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, Vinicius Farias; Moreira, Robson Prates [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

    2012-07-01

    The unitization process is required in most regulatory models around the world when it identifies that a reservoir straddles to out of the contracted area. This procedure aims to ensure a greater exploitation of petroleum. In Brazil is no different; however there are still many ambiguities in this process. The introduction of new tax regimes in the country broadened the doubts, as we may have a reservoir straddling between concession, production sharing, assignment of rights areas and areas not yet contracted. The objective of the present paper is to explore the uncertainties that must be addressed by the oil and gas sector in order to ensure low legal, regulatory and fiscal risks in the oil industry. The main topics discussed are the rules for production allocation, reserves and expenditures, the ANP and PPSA roles' conflicts, restriction of parties' rights, adjustment of contractual rules and also mitigate or eliminate economic, financial and fiscal uncertainties. This article does not propose solutions to all lacks raised. (author)

  13. Politics versus Science in the Making of a New Regulatory Regime for Food in Europe

    OpenAIRE

    Richard Keefer

    2001-01-01

    The European Union's new food regulatory regime can be understood as a political, rather than science-based solution to the problem of recurrent food crises that have threatened the foundations of the single market. The failure of first, mutual trust and subsequently, its remedy, comitology, led to calls for an agency solution. The question of whether to invest an agency with the three powers of risk assessment, communication, and management can be understood as a struggle to define the role ...

  14. Current status of developmental neurotoxicity: regulatory view

    DEFF Research Database (Denmark)

    Hass, Ulla

    2003-01-01

    . Until recently, however, developmental neurotoxicity testing of industrial chemicals has not been a clear regulatory requirement in EU, probably due to the lack of an accepted OECD TG. The revised EU Technical Guidance Document for Risk Assessment (EU-TGD) has now included the OECD draft TG 426...... in the testing strategy for new and existing substances, and biocides. Hopefully, this will lead to an improved database for risk assessment of potential developmental neurotoxicants. However, the regulatory authorities and toxicologists will also be faced with the challenge that decisions have to be made......The need for developmental neurotoxicity testing has been recognized for decades and guidelines are available, as the USEPA guideline and the OECD draft TG 426. Regulatory testing of industrial chemicals for developmental neurotoxicity is required to some extent, especially for pesticides in the US...

  15. Current approaches to gene regulatory network modelling

    Directory of Open Access Journals (Sweden)

    Brazma Alvis

    2007-09-01

    Full Text Available Abstract Many different approaches have been developed to model and simulate gene regulatory networks. We proposed the following categories for gene regulatory network models: network parts lists, network topology models, network control logic models, and dynamic models. Here we will describe some examples for each of these categories. We will study the topology of gene regulatory networks in yeast in more detail, comparing a direct network derived from transcription factor binding data and an indirect network derived from genome-wide expression data in mutants. Regarding the network dynamics we briefly describe discrete and continuous approaches to network modelling, then describe a hybrid model called Finite State Linear Model and demonstrate that some simple network dynamics can be simulated in this model.

  16. Politics versus Science in the Making of a New Regulatory Regime for Food in Europe

    Directory of Open Access Journals (Sweden)

    Laurie Buonanno

    2001-10-01

    Full Text Available The European Union's new food regulatory regime can be understood as a political, rather than science-based solution to the problem of recurrent food crises that have threatened the foundations of the single market. The failure of first, mutual trust and subsequently, its remedy, comitology, led to calls for an agency solution. The question of whether to invest an agency with the three powers of risk assessment, communication, and management can be understood as a struggle to define the role of the scientist in the management of regulatory policy. Scientists base their recommendations on probabilities; politicians are accountable to a public that expects government to guarantee zero risk. The outcome, a European Food Authority (EFA, preserves the management function and the Rapid Alert System within the Commission. EFA's success will rest on the harmonization of food law in Member States and the creation of a network between the EFA and Member State food agencies. Satisfaction of these goals, in turn, depends upon transparency, open communication, and willingness to cooperate. An unintended consequence of the new regulatory regime for food may be to strengthen corporate food producers and accelerate food homogeneity within Europe. These processes carry their own set of problems regarding interest group behavior, unconventional political behavior, and voter mobilization. We close the paper with recommendations for future research.

  17. Current european regulatory perspectives on insulin analogues

    Directory of Open Access Journals (Sweden)

    Enzmann Harald G

    2011-07-01

    Full Text Available Abstract Insulin analogues are increasingly considered as an alternative to human insulin in the therapy of diabetes mellitus. Insulin analogues (IAs are chemically different from human insulin and may have different pharmacokinetic or pharmacodynamic properties. The significance of the modifications of the insulin molecule for the safety profile of IAs must be considered. This review describes the regulatory procedure and the expectations for the scientific content of European marketing authorization applications for innovative IAs submitted to the European Medicines Agency. Particular consideration is given to a potential cancer hazard. Specific regulatory guidance on how to address a possible carcinogenic or tumor promoting effect of innovative IAs in non-clinical studies is available. After marketing authorization, the factual access of patients to the new product will be determined to great extent by health technology assessment bodies, reimbursement decisions and the price. Whereas the marketing authorization is a European decision, pricing and reimbursement are national or regional responsibilities. The assessment of benefit and risk by the European Medicines Agency is expected to influence future decisions on price and reimbursement on a national or regional level. Collaborations between regulatory agencies and health technology assessment bodies have been initiated on European and national level to facilitate the use of the European Medicines Agency's benefit risk assessment as basis on which to build the subsequent health technology assessment. The option for combined or joint scientific advice procedures with regulators and health technology assessment bodies on European level or on a national level in several European Member States may help applicants to optimize their development program and dossier preparation in regard of both European marketing authorization application and reimbursement decisions.

  18. ON THE CURRENT RMB EXCHANGE RATE REGIME AFFECTING THE EFFECTIVENESS OF MONETARY POLICY

    Institute of Scientific and Technical Information of China (English)

    黄燕君

    2001-01-01

    The current exchange rate regime of China is just like the US dollar-pegged exchange rate regime, which weakens the effectiveness of monetary policy but increases the effectiveness of fiscal policy. Since the scope of implementing the fiscal policy is quite narrow, it is necessary to promote the effectiveness of monetary policy by enlarging the elasticity of the RMB exchange rate regime so as to stimulate the rapid development of the Chinese economy effectively.

  19. Langmuir probe study in the nonresonant current drive regime of helicon discharge

    Indian Academy of Sciences (India)

    Manash Kumar Paul; Dhiraj Bora

    2008-07-01

    Characterization of the current drive regime is done for helicon wave-generated plasma in a torus, at a very high operating frequency. A radiofrequency-compensated Langmuir probe is designed and used for the measurement of plasma parameters along with the electron energy distributions in radial scans of the plasma. The electron energy distribution patterns obtained in the operational regime suggest that Landau damping cannot be responsible for the efficient helicon discharge in the present study. A typical peaked radial density profile, high plasma temperature and absence of an appreciable amount of energetic electrons for resonant wave–particle interactions, suggest that the chosen operational regime is suitable for the study of nonresonant current drive by helicon wave. Successful and significant current drive achieved in our device clearly demonstrates the capability of nonresonant current drive by helicon waves in the present operational regime.

  20. Numerical Solution of Lock-Release Gravity Current with Viscous Self-Similar Regime

    Institute of Scientific and Technical Information of China (English)

    张立柱; 李行伟; 陈国谦

    2004-01-01

    Lock-release gravity currents with a viscous self-similar regime are simulated by use of the renormalization group (RNG) k - ε model for Reynolds-stress closure. Besides the turbulent regime with initially a slumping phase of a constant current front speed and later an inviscid self-similar phase of front speed decreasing as t-1/3(where t is the time measured from release), the viscous self-similar regime is satisfactorily reproduced with front speed decreasing as t-4/5,consistent with well known experimental observations.

  1. Regime complexity and expertise in transnational governance: Strategizing in the face of regulatory uncertainty

    Directory of Open Access Journals (Sweden)

    Sigrid Quack

    2013-01-01

    Full Text Available The rise and spread of transnational governance arrangements has added to the legal indeterminacy of existing regime complexes. The combined regulatory uncertainty resulting from international regime complexes and transnational polycentric governance heightens the role of expertise in managing this institutional complexity. The rising importance of knowledgeable actors with claims to policy-relevant expertise, according to many scholars, is expected further to advantage well-resourced and powerful actors. However, attention to recent developments in accounting and copyright, as two transnational governance fields that have been dominated by a small group of powerful actors for more than three decades, sheds doubt on the generalizability of such arguments. Although representing least likely cases for change, the empirical evidence presented in this paper shows how apparently weak or marginalized actors – whether they are part of public bureaucracies or civil society – developed expertise-based strategies to claim greater involvement and influence in rule and standard-setting. Their strategizing on regime complexity opened up previously shielded policy spaces to broader audiences, thereby transforming actor constellations, preferences and problem definitions in the two policy fields. These findings suggest that under conditions of complexity, indeterminacy and uncertainty, claims to expertise-based rule are becoming increasingly contested – even in transnational governance fields that have a long-established trajectory of rule-setting and rule-implementation monopolized by small groups of professionals, industrialists or technical diplomats. El surgimiento y la difusión de las disposiciones de gobierno transnacional ha contribuido a la indeterminación jurídica de los complejos regímenes existentes. La incertidumbre regulatoria resultante de los complejos regímenes internacionales y del gobierno policéntrico transnacional realza el

  2. Implications of Convergence on the Regulatory Regime, e-Commerce, the Industry, and the Society at large in South Africa

    OpenAIRE

    Mlitwa, Nhlanhla Boyfriend

    2004-01-01

    Convergence in information communication technology is about real issues of technological innovations and change. It encompasses a combination of benefits and challenges, not only for the market, the industry, or technology sectors, but also for the regulatory regime and the society at large. Technology convergence offers massive opportunities for the development of new services and the expansion of consumer choice. It certainly expands the overall information market, and is the catalyst f...

  3. The Effectiveness of the Regulatory Regime for Black Carbon Mitigation in the Arctic

    Directory of Open Access Journals (Sweden)

    Daria Shapovalova

    2016-11-01

    Full Text Available In addition to being a hazardous air pollutant, Black Carbon is the second-largest contributor to Arctic warming. Its mitigation is being addressed at the international regulatory level by the Arctic Council and the Convention on Long-Range Transboundary Air Pollution (CLRTAP. Whilst the Convention and its protocols are binding documents, the Black Carbon regulation under their framework appears to have ‘soft law’ characteristics. At the same time, the voluntary Black Carbon and Methane Framework, adopted by the Arctic Council, demonstrates positive compliance and follow-up dynamics compared to earlier norm-creating attempts. This paper argues that the nature of the norm (binding or non-binding is not the decisive factor regarding effective implementation in the Arctic region. Current efforts to mitigate Black Carbon by means of a non-binding Arctic Council Black Carbon and Methane Framework represent an improvement in the Council's normative function and may have more effect on the behaviour of Arctic States than relevant provisions under the Gothenburg Protocol to the CLRTAP. To support this argument, the first section presents an overview of the Arctic Council as an actor in Arctic policy-making. It then provides an assessment of current efforts to combat Black Carbon carried out by the Arctic Council and the CLRTAP.

  4. A New Regime for Studying the High Bootstrap Current Fraction Plasma

    Institute of Scientific and Technical Information of China (English)

    A. Isayama; Y. Kamada; K. Ushigusa; T. Fujita; T. Suzuki; X. Gao

    2001-01-01

    A new experimental regime has recently been studied for achieving the high fraction of the bootstrap current in the JT-60U hydrogen discharges. The high poloidal beta(βp ~ 3.61) plasma was obtained by high-power neutral beam injection heating at a very high edge safety factor (Ip = 0.3 MA, Bt = 3.65 T, qeff = 25 - 35) region, and the bootstrap current fraction (fBS) was correspondingly about 40% using the ACCOME code calculation. It was observed that there were no magnetohydrodynamic instabilities to retard the increase of the βp and fBS parameters in the new regime.

  5. Liquid Biopsies in Oncology and the Current Regulatory Landscape.

    Science.gov (United States)

    Strotman, Lindsay N; Millner, Lori M; Valdes, Roland; Linder, Mark W

    2016-10-01

    There is a profound need in oncology to detect cancer earlier, guide individualized therapies, and better monitor progress during treatment. Currently, some of this information can be achieved through solid tissue biopsy and imaging. However, these techniques are limited because of the invasiveness of the procedure and the size of the tumor. A liquid biopsy can overcome these barriers as its non-invasive nature allows samples to be collected over time. Liquid biopsies may also allow earlier detection than traditional imaging. Liquid biopsies include the analysis of circulating tumor cells (CTCs), cell-free nucleic acid (cfNA), or extracellular vesicles obtained from a variety of biofluids, such as peripheral blood. In this review, we discuss different liquid biopsy types and how they fit into the current regulatory landscape.

  6. Analytical drain current model for amorphous IGZO thin-film transistors in abovethreshold regime

    Institute of Scientific and Technical Information of China (English)

    He Hongyu; Zheng Xueren

    2011-01-01

    An analytical drain current model is presented for amorphous In-Ga-Zn-oxide thin-film transistors in the above-threshold regime,assuming an exponential trap states density within the bandgap.Using a charge sheet approximation,the trapped and free charge expressions are calculated,then the surface potential based drain current expression is developed.Moreover,threshold voltage based drain current expressions are presented using the Taylor expansion to the surface potential based drain current expression.The calculated results of the surface potential based and threshold voltage based drain current expressions are compared with experimental data and good agreements are achieved.

  7. Study of multipass regimes in lower hybrid current drive experiments on Tore Supra

    Energy Technology Data Exchange (ETDEWEB)

    Arslanbekov, R.; Litaudon, X.; Peysson, Y.; Hoang, G.T.; Kazarian, F.; Moreau, D. [Association Euratom-CEA, Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee; Shoucri, M.; Shkarofsky, I.P. [Centre Canadien de Fusion Magnetique, Varennes, PQ (Canada); Baranov, Y. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Kupfer, K. [General Atomics, San Diego, CA (United States)

    1995-12-31

    This document presents a study of multipass regimes in Lower Hybrid Current Drive on Tore Supra. A statistical model of the plasma wave propagation based on the Fokker-Planck theory is proposed, together with experimental results performed on Tore Supra. (TEC). 9 refs., 4 figs.

  8. Modelling of eddy-current interaction with cracks in the thin-skin regime. Two approaches

    Energy Technology Data Exchange (ETDEWEB)

    Mastorchio, S. [Electricite de France, 78 - Chatou (France). Research and Development Div.; Harfield, N. [Surrey Univ. (United Kingdom). Dept. of Physics

    1998-02-01

    EDF uses TRIFOU code for eddy current testing modelling. This general electromagnetic code is to be further adapted to Non Destructive Testing applications, not only for nuclear NDT but also in other fields such as aeronautical. This paper compares experimental data for aluminium and steel specimens with two methods of solving the forward problem in the thin-skin regime. The first approach is a 3D Finite Element / Boundary Integral Element method (TRIFOU) developed by EDF/RD Division (France). The second approach is specialized for the treatment of surface cracks in the thin-skin regime developed by the University of Surrey (England). In the thin-skin regime, the electromagnetic skin-depth is small compared with the depth of the crack. Such conditions are common in tests on steels and sometimes on aluminium. (K.A.) 4 refs.

  9. Regime shifts in demersal assemblages of the Benguela Current Large Marine Ecosystem: a comparative assessment

    DEFF Research Database (Denmark)

    Kirkman, Stephen P.; Yemane, Dawit; Atkinson, Lara J.

    2015-01-01

    Using long‐term survey data, changes in demersal faunal communities in the Benguela Current Large Marine Ecosystem were analysed at community and population levels to provide a comparative overview of the occurrence and timing of regime shifts. For South Africa, the timing of a community‐level sh......Using long‐term survey data, changes in demersal faunal communities in the Benguela Current Large Marine Ecosystem were analysed at community and population levels to provide a comparative overview of the occurrence and timing of regime shifts. For South Africa, the timing of a community......‐level shift observed in the early 1990s, and of a lesser shift observed in the mid‐2000s, corresponded well with the results of other studies that showed environmental, community‐level or population‐level changes at similar times, suggesting that environmental forcing had played a role. Several population......‐level shifts were detected for Namibia; these and a regime shift in the overall community identified for this country corresponded well to the timing of severe environmental perturbations and an extensive regime shift in the pelagic ecosystem of this area. However, the interpretation of these shifts...

  10. The Global Diffusion of Regulatory Instruments: The Making of a New International Environmental Regime

    Directory of Open Access Journals (Sweden)

    Busch

    2004-12-01

    Full Text Available During the 1990s a new regulatory pattern in domestic environmental policymaking has been emerging which is characterized by an increasing use of cooperative, informational and marked-based instruments. This pattern is to an important extent a result of international policy diffusion – the cross-national spread of policy innovations driven by information flows rather than hierarchical or collective decision-making within international institutions. Based on four case studies, the paper demonstrates empirically how horizontal diffusion processes accompanied by information and recommendations from international organizations have led to the adoption of new regulatory instruments in an increasing number of countries and how these individual national adoptions add up to an emerging regulatory structure at the international level. At the macro-level, the case studies explore how diffusion interacts with the other two major international mechanisms of domestic policy change: legal harmonization and coercive imposition. Especially within the European Union a typical pattern of horizontal diffusion between individual member states, followed by vertical diffusion from the national to the EU-level and finally leading to an EU-wide legal harmonization through EC-directives can be identified. At the micro-level, the paper investigates which factors promote or obstruct the diffusion of new environmental policy instruments. While the endorsement of regulatory instruments by international organizations or transnational advocacy networks often facilitates their diffusion, the instruments' characteristics determine the extent and speed by which regulatory instruments spread across countries. As regards policymakers' motivation for voluntarily adopting regulatory instruments, the paper argues that it cannot be exclusively explained by rational attempts to improve policy effectiveness. In addition, policy adoption is often motivated by concerns of legitimacy and

  11. The Global Diffusion of Regulatory Instruments: The Making of a New International Environmental Regime

    Directory of Open Access Journals (Sweden)

    Kerstin Tews

    2004-12-01

    Full Text Available During the 1990s a new regulatory pattern in domestic environmental policymaking has been emerging which is characterized by an increasing use of cooperative, informational and marked-based instruments. This pattern is to an important extent a result of international policy diffusion the cross-national spread of policy innovations driven by information flows rather than hierarchical or collective decision-making within international institutions. Based on four case studies, the paper demonstrates empirically how horizontal diffusion processes accompanied by information and recommendations from international organizations have led to the adoption of new regulatory instruments in an increasing number of countries and how these individual national adoptions add up to an emerging regulatory structure at the international level. At the macro-level, the case studies explore how diffusion interacts with the other two major international mechanisms of domestic policy change: legal harmonization and coercive imposition. Especially within the European Union a typical pattern of horizontal diffusion between individual member states, followed by vertical diffusion from the national to the EU-level and finally leading to an EU-wide legal harmonization through EC-directives can be identified. At the micro-level, the paper investigates which factors promote or obstruct the diffusion of new environmental policy instruments. While the endorsement of regulatory instruments by international organizations or transnational advocacy networks often facilitates their diffusion, the instruments' characteristics determine the extent and speed by which regulatory instruments spread across countries. As regards policymakers' motivation for voluntarily adopting regulatory instruments, the paper argues that it cannot be exclusively explained by rational attempts to improve policy effectiveness. In addition, policy adoption is often motivated by concerns of legitimacy and

  12. Regulatory risk control through mandatory occupational safety and health (OSH) certification and testing regimes (CTRs)

    NARCIS (Netherlands)

    Zwetsloot, G.I.J.M.; Hale, A.; Zwanikken, S.

    2011-01-01

    Governments make increasing use of private certification and testing infrastructures as an alternative for traditional regulatory arrangements in several areas including occupational safety and health (OSH).This research, commissioned by the Dutch Inspectorate for Work and Income (IWI), concerns an

  13. Regulatory risk control through mandatory occupational safety and health (OSH) certification and testing regimes (CTRs)

    NARCIS (Netherlands)

    Zwetsloot, G.I.J.M.; Hale, A.; Zwanikken, S.

    2011-01-01

    Governments make increasing use of private certification and testing infrastructures as an alternative for traditional regulatory arrangements in several areas including occupational safety and health (OSH).This research, commissioned by the Dutch Inspectorate for Work and Income (IWI), concerns an

  14. Regime shifts of Cruces River wetland ecosystem: current conditions, future uncertainties

    Directory of Open Access Journals (Sweden)

    Víctor H Marín

    2014-03-01

    Full Text Available During April-May 2004 the Cruces River wetland ecosystem, located in Valdivia (40°S, southern Chile, was described as shifting from a clear water regime, dominated by the exotic macrophyte Egeria densa, to turbid waters and absence of submerged macrophytes. We analyzed the trophic status and ecological regime of the wetland from November 2011 through January 2013. The trophic status was determined comparing values of selected variables (nutrients, chlorophyll-a and transparency with OECD criteria. The ecological regime was determined comparing the same variables with the criteria proposed by Ibelings et al. (2007. We further compared the concentration of nutrients and suspended solids with previous measurements. Current trophic status of the wetland is between eutrophic and hypereutrophic, as shown by results, and its ecological regime intermediate, between clear and turbid waters, with a considerable risk of returning to turbid waters. In this article we discuss the potential relationship between the watershed land use (agriculture, cattle feeding and forestry, the change in wetland's trophic level and future conditions.

  15. Dynamics of the Plasmoid-unstable Regime in Different Multiple-current Plasmas

    Science.gov (United States)

    Nemati, M. J.; Wang, Zheng-Xiong; Wei, Lai

    2017-02-01

    The dynamics of plasmoid instability in multiple-current plasmas with different system sizes is investigated by means of resistive magnetohydrodynamic simulations. As the system size is increased, the secondary current sheets become very long, producing more plasmoids. It is found that the dependence on resistivity η of the number of plasmoids changes from no clear scaling for small system size, to scaling in ∼ {η }-1 for large system size. Moreover, increasing the current length of the system weakens the negative dependence of the early growth rate of the monster plasmoid on η. This is qualitatively different from the reconnection rate for a single-current sheet, where it usually has a positive dependence on η or is independent of η. In addition, increasing the current length significantly increases the maximum width of the monster plasmoid in the low-η regime, manifesting a scaling ∼ {η }-0.4.

  16. Modeling and analysis of sub-surface leakage current in nano-MOSFET under cutoff regime

    Science.gov (United States)

    Swami, Yashu; Rai, Sanjeev

    2017-02-01

    The high leakage current in nano-meter regimes is becoming a significant portion of power dissipation in nano-MOSFET circuits as threshold voltage, channel length, and gate oxide thickness are scaled down to nano-meter range. Precise leakage current valuation and meticulous modeling of the same at nano-meter technology scale is an increasingly a critical work in designing the low power nano-MOSFET circuits. We present a specific compact model for sub-threshold regime leakage current in bulk driven nano-MOSFETs. The proposed logical model is instigated and executed into the latest updated PTM bulk nano-MOSFET model and is found to be in decent accord with technology-CAD simulation data. This paper also reviews various transistor intrinsic leakage mechanisms for nano-MOSFET exclusively in weak inversion, like drain-induced barricade lowering (DIBL), gate-induced drain leakage (GIDL), gate oxide tunneling (GOT) leakage etc. The root cause of the sub-surface leakage current is mainly due to the nano-scale short channel length causing source-drain coupling even in sub-threshold domain. Consequences leading to carriers triumphing the barricade between the source and drain. The enhanced model effectively considers the following parameter dependence in the account for better-quality value-added results like drain-to-source bias (VDS), gate-to-source bias (VGS), channel length (LG), source/drain junction depth (Xj), bulk doping concentration (NBULK), and operating temperature (Top).

  17. Electricity distribution as an unsustainable natural monopoly. A potential outcome of New Zealand's regulatory regime

    Energy Technology Data Exchange (ETDEWEB)

    Gunn, C. [Energy and Mining Sector Unit, East Asia and Pacific Region, The World Bank, Washington, DC (United States); Sharp, B. [Department of Economics, Tamaki Campus, University of Auckland, Auckland (New Zealand)

    1999-08-01

    The ongoing reform of New Zealand's electricity supply industry has attempted to separate its potentially competitive elements from those with naturally monopolistic characteristics. Yet, some competition for distribution services is occurring, raising the question as to whether electricity distributors are natural monopolies as is typically assumed. This paper presents a simple model of a representative New Zealand distribution business, and shows that, in a true economic sense, distributors are most probably sustainable natural monopolies as expected. However, the model demonstrates that a mechanism for competition may arise because the financial principles enshrined in the Ministry of Commerce's regulatory regime can produce unsustainable cost structures and unintentionally introduce elements of contestability into the market for distribution services. 15 refs.

  18. The impact of current visa regime policy on tourism recovery and development in Zimbabwe

    Directory of Open Access Journals (Sweden)

    Nelson Zengeni

    2012-12-01

    Full Text Available This paper reports the results on the impact of the current visa regime policy on tourism recovery and development in Zimbabwe. The focus was on finding out how the visa regime could impact on efforts to bring into the country more visitors following the decline in visitor inflows from 2000 to 2008. Data was collected from selected visitors from different member states which require visas to enter into the county in the period between January 2010 and July 2010.The findings shows that visa restrictions play a small part in discouraging visitors to visit Zimbabwe. The visa regime policy was designed in such a way that it was easy for passport holders from traditional markets to have relatively easy passage into Zimbabwe. It was also discovered that visa restrictions were part of international travel conditions but how to get the visa became the competitive advantage or disadvantage a destination can have compared with its competitors. Zimbabwe’s traditional markets believed that the visa was not difficult to get nor was it too expensive as to scare away visitors. However, the emerging markets such as China who are in Group C had problems getting the visa as they were required to apply for the visa before traveling to Zimbabwe.

  19. Protection of the African Lion: A Critical Analysis of the Current International Legal Regime

    Directory of Open Access Journals (Sweden)

    Samantha Watts

    2016-04-01

    Full Text Available This article looks at the current international regime that pertains to the African lion, a species that needs adequate protection across its range (a range that does not adhere to state boundaries. This analysis comes at a time when threats such as habitat and prey loss, retaliatory killing, trophy hunting and trade, are all impacting the remaining populations of African lions. The species is in danger of rapid population decline and possible extinction in the near future. Two decades ago there was an abundance of African lions, roughly 100 000, on the continent. But at present there are less than 32 000, while some believe there to be as little as 15 000 left. This decline is mainly due to the threats noted above. African lions are currently listed as "vulnerable" on the International Union for Conservation of Nature Red List of Threatened Species. This listing is being contested by commentators who believe that the species now requires an "endangered" status. African lion populations, and the threats to the species, extend across state boundaries. Therefore, international law is of particular importance in providing conservation and protection measures to the species. Creating conservation obligations at a global level allows for more uniform action, implementation and enforcement of legislation at regional and local levels. Therefore this article looks at each threat to African lion populations in detail and then assesses the international legal regime pertaining to each of these threats, and whether that regime is adequate. The Convention on Biological Diversity, Convention on the Conservation of Migratory Species, Convention on International Trade in Endangered Species of Wild Fauna and Flora and the Convention on Wetlands of International Importance are but some of the international instruments that are analysed. This article outlines the arguments that the international legal framework is not acceptable for the protection of the species

  20. Evolving PBPK applications in regulatory risk assessment: current situation and future goals

    Science.gov (United States)

    The presentation includes current applications of PBPK modeling in regulatory risk assessment and discussions on conflicts between assuring consistency with experimental data in current situation and the desire for animal-free model development.

  1. Role of head of turbulent 3-D density currents in mixing during slumping regime

    Science.gov (United States)

    Bhaganagar, Kiran

    2017-02-01

    A fundamental study was conducted to shed light on entrainment and mixing in buoyancy-driven Boussinesq density currents. Large-eddy simulation was performed on lock-exchange (LE) release density currents—an idealized test bed to generate density currents. As dense fluid was released over a sloping surface into an ambient lighter fluid, the dense fluid slumps to the bottom and forms a characteristic head of the current. The dynamics of the head dictated the mixing processes in LE currents. The key contribution of this study is to resolve an ongoing debate on mixing: We demonstrate that substantial mixing occurs in the early stages of evolution in an LE experiment and that entrainment is highly inhomogeneous and unsteady during the slumping regime. Guided by the flow physics, entrainment is calculated using two different but related perspectives. In the first approach, the entrainment parameter (E) is defined as the fraction of ambient fluid displaced by the head that entrains into the current. It is an indicator of the efficiency in which ambient fluid is displaced into the current and it serves as an important metric to compare the entrainment of dense currents over different types of surfaces, e.g., roughness configuration. In the second approach, E measures the net entrainment in the current at an instantaneous time t over the length of the current. Net entrainment coefficient is a metric to compare the effects of flow dynamical conditions, i.e., lock-aspect ratio that dictates the fraction of buoyancy entering the head, and also the effect of the sloping angle. Together, the entrainment coefficient and the net entrainment coefficient provide an insight into the entrainment process. The "active" head of the current acts as an engine that mixes the ambient fluid with the existing dense fluid, the 3-D lobes and clefts on the frontal end of the current causes recirculation of the ambient fluid into the current, and Kelvin-Helmholtz rolls are the mixers that

  2. Current and future applications of PRA in regulatory activities

    Energy Technology Data Exchange (ETDEWEB)

    Speis, T.P.; Murphy, J.A.; Cunningham, M.A. [Nuclear Regulatory Commission, Washington, DC (United States)] [and others

    1995-04-01

    Probabilistic Risk Assessments (PRAs) have proven valuable in providing the regulators, the nuclear plant operators, and the reactor designers insights into plant safety, reliability, design and operation. Both the NRC Commissioners and the staff have grown to appreciate the valuable contributions PRAs can have in the regulatory arena, though I will admit the existence of some tendencies for strict adherence to the deterministic approach within the agency and the public at large. Any call for change, particularly one involving a major adjustment in approach to the regulation of nuclear power, will meet with a certain degree of resistance and retrenchment. Change can appear threatening and can cause some to question whether the safety mission is being fulfilled. This skepticism is completely appropriate and is, in fact, essential to a proper transition towards risk and performance-based approaches. Our task in the Office of Nuclear Regulatory Research is to increase the PRA knowledge base within the agency and develop appropriate guidance and methods needed to support the transitioning process.

  3. Heating, current drive and confinement regimes with the JET ICRH and LHCD systems

    DEFF Research Database (Denmark)

    Jacquinot, J.; Adams, J.M.; Altmann, H.;

    1991-01-01

    During its 1990 operation, 2 large RF systems were available on JET. The Ion Cyclotron Resonance Heating (ICRH) system was equipped with new beryllium screens and with feedback matching systems. Specific impurities generated by ICRH were reduced to negligible levels even in the most stringent H......-mode conditions. A maximum power of 22 MW was coupled to L-mode plasmas. High quality H-modes (tau-E greater-than-or-equal-to 2.5 tau-EG) were achieved using dipole phasing. A new high confinement mode was discovered. It combines the properties of the H-mode regime to the low central diffusivities obtained....... Paradoxically, LHCD induces central heating particularly in combination with ICRH. Finally we present the first observations of the synergistic acceleration of fast electrons by Transit Time Magnetic Pumping (TTMP) (from ICRH) and Electron Landau Damping (ELD) (from LHCD). The synergism generates TTMP current...

  4. Coincident polio and Ebola crises expose similar fault lines in the current global health regime.

    Science.gov (United States)

    Calain, Philippe; Abu Sa'Da, Caroline

    2015-01-01

    In 2014, the World Health Organization (WHO) declared two "public health emergencies of international concern", in response to the worldwide polio situation and the Ebola epidemic in West Africa respectively. Both emergencies can be seen as testing moments, challenging the current model of epidemic governance, where two worldviews co-exist: global health security and humanitarian biomedicine. The resurgence of polio and the spread of Ebola in 2014 have not only exposed the weaknesses of national health systems, but also the shortcomings of the current global health regime in dealing with transnational epidemic threats. These shortcomings are of three sorts. Firstly, the global health regime is fragmented and dominated by the domestic security priorities of industrialised nations. Secondly, the WHO has been constrained by constitutional country allegiances, crippling reforms and the limited impact of the (2005) International Health Regulations (IHR) framework. Thirdly, the securitization of infectious diseases and the militarization of humanitarian aid undermine the establishment of credible public health surveillance networks and the capacity to control epidemic threats. The securitization of communicable diseases has so far led foreign aid policies to sideline health systems. It has also been the source of ongoing misperceptions over the aims of global health initiatives. With its strict allegiance to Member States, the WHO mandate is problematic, particularly when it comes to controlling epidemic diseases. In this context, humanitarian medical organizations are expected to palliate the absence of public health services in the most destitute areas, particularly in conflict zones. The militarization of humanitarian aid itself threatens this fragile and imperfect equilibrium. None of the reforms announced by the WHO in the wake of the 68(th) World Health Assembly address these fundamental issues.

  5. Benchmark continuum and kinetic simulations of argon microplasmas in the direct current and microwave regimes

    Science.gov (United States)

    Verma, Abhishek Kumar; Alamatsaz, Arghavan; Venkattraman, Ayyaswamy

    2017-10-01

    This study presents benchmark comparisons between continuum and kinetic simulations of argon microplasmas operating in the direct current and microwave regimes. Kinetic simulations using the particle-in-cell with Monte Carlo collisions (PIC-MCC) method and continuum simulations using the full-momentum equation for both ions and electrons are performed at various operating conditions in order to study the influence of product of pressure and gap size, pd (for a given gap size), influence of gap size (for a given value of pd) and operating frequency. It is shown that using the electron energy distribution function (EEDF) predicted by zero-dimensional Boltzmann solvers (such as BOLSIG+) in continuum simulations of direct current microplasmas leads to a significant under-prediction of plasma number densities with continuum simulations based on the Maxwellian EEDF performing better particularly for higher values of pd. The discrepancy between kinetic and continuum simulations is attributed to the presence of hot electrons created as a result of secondary emission and subsequent acceleration in the sheath. On the other hand, simulations performed for argon microwave microplasmas operating at 0.5 GHz, 0.8 GHz, 2 GHz and 4 GHz demonstrated that continuum simulations performed using the rate constants from BOLSIG+  showed excellent agreement with kinetic simulations for the plasma density profiles in spite of over-predicting the voltage/power required to achieve a given plasma density.

  6. Current Status of Regulatory Science Education in Faculties of Pharmaceutical Science in Japan.

    Science.gov (United States)

    Tohkin, Masahiro

    2017-01-01

     I introduce the current pharmaceutical education system in Japan, focusing on regulatory science. University schools or faculties of pharmaceutical science in Japan offer two courses: a six-year course for pharmacists and a four-year course for scientists and technicians. Students in the six-year pharmaceutical course receive training in hospitals and pharmacies during their fifth year, and those in the four-year life science course start research activities during their third year. The current model core curriculum for pharmaceutical education requires them to "explain the necessity and significance of regulatory science" as a specific behavior object. This means that pharmacists should understand the significance of "regulatory science", which will lead to the proper use of pharmaceuticals in clinical practice. Most regulatory science laboratories are in the university schools or faculties of pharmaceutical sciences; however, there are too few to conduct regulatory science education. There are many problems in regulatory science education, and I hope that those problems will be resolved not only by university-based regulatory science researchers but also by those from the pharmaceutical industry and regulatory authorities.

  7. Current climate change effects on the ground thermal regime in Central Yakutia

    Institute of Scientific and Technical Information of China (English)

    Stepan Varlamov; Yuri Skachkov; Pavel Skryabin

    2014-01-01

    The-evolution-of-ground-thermal-state-has-been-studied-to-assess-impacts-of-current-climatic-warming-on-permafrost-in-Central-Yakutia.-The-analysis-of-long-term-data-of-regional-weather-stations-has-revealed-one-of-the-highest-increasing-trends-in-mean-annual-air-temperature-in-northern-Russia.-A-forecast-of-surface-air-temperature-fluctuations-has-been-made-by-applying-a-frequency-analysis-method.-Monitoring-of-ground-thermal-conditions-allows-us-to-identify-inter-annual-and-long-term-variability-among-a-wide-range-of-natural-conditions.-Experimental-research-has-indicated-a-long-term-dynamics-of-ground-thermal-state-evolution:-ground-temperatures-at-the-depth-of-zero-annual-amplitude-and-seasonally-thawed-layer-depth.-Long-term-variability-of-thaw-depth-shows-near-zero-to-weak-positive-trends-in-small-valleys-in-contrast-to-weak-negative-trends-on-slopes.-With-significant-climatic-warming,-the-thermal-state-of-near-surface-layers-of-permafrost-demonstrates-steadiness.-Anthropogenic-impacts-on-ground-thermal-regime-in-various-terrain-types-have-been-qualitatively-evaluated.-Clear-cutting,-ground-cover-stripping,-and-post-fire-deforestation-in-inter-alas-type-terrains-result-in-a-significant-increase-of-temperature-and-seasonal-ground-thaw-depth,-as-well-as-adverse-cryogenic-processes.-The-dynamics-of-mean-annual-ground-temperature-in-slash-and-burn-sites-have-been-evaluated-in-reference-to-stages-of-successive-vegetation-recovery.

  8. Progress toward steady-state tokamak operation exploiting the high bootstrap current fraction regime

    Science.gov (United States)

    Ren, Q. L.; Garofalo, A. M.; Gong, X. Z.; Holcomb, C. T.; Lao, L. L.; McKee, G. R.; Meneghini, O.; Staebler, G. M.; Grierson, B. A.; Qian, J. P.; Solomon, W. M.; Turnbull, A. D.; Holland, C.; Guo, W. F.; Ding, S. Y.; Pan, C. K.; Xu, G. S.; Wan, B. N.

    2016-06-01

    Recent DIII-D experiments have increased the normalized fusion performance of the high bootstrap current fraction tokamak regime toward reactor-relevant steady state operation. The experiments, conducted by a joint team of researchers from the DIII-D and EAST tokamaks, developed a fully noninductive scenario that could be extended on EAST to a demonstration of long pulse steady-state tokamak operation. Improved understanding of scenario stability has led to the achievement of very high values of βp and βN , despite strong internal transport barriers. Good confinement has been achieved with reduced toroidal rotation. These high βp plasmas challenge the energy transport understanding, especially in the electron energy channel. A new turbulent transport model, named TGLF-SAT1, has been developed which improves the transport prediction. Experiments extending results to long pulse on EAST, based on the physics basis developed at DIII-D, have been conducted. More investigations will be carried out on EAST with more additional auxiliary power to come online in the near term.

  9. Towards time-dependent current-density-functional theory in the non-linear regime.

    Science.gov (United States)

    Escartín, J M; Vincendon, M; Romaniello, P; Dinh, P M; Reinhard, P-G; Suraud, E

    2015-02-28

    Time-Dependent Density-Functional Theory (TDDFT) is a well-established theoretical approach to describe and understand irradiation processes in clusters and molecules. However, within the so-called adiabatic local density approximation (ALDA) to the exchange-correlation (xc) potential, TDDFT can show insufficiencies, particularly in violently dynamical processes. This is because within ALDA the xc potential is instantaneous and is a local functional of the density, which means that this approximation neglects memory effects and long-range effects. A way to go beyond ALDA is to use Time-Dependent Current-Density-Functional Theory (TDCDFT), in which the basic quantity is the current density rather than the density as in TDDFT. This has been shown to offer an adequate account of dissipation in the linear domain when the Vignale-Kohn (VK) functional is used. Here, we go beyond the linear regime and we explore this formulation in the time domain. In this case, the equations become very involved making the computation out of reach; we hence propose an approximation to the VK functional which allows us to calculate the dynamics in real time and at the same time to keep most of the physics described by the VK functional. We apply this formulation to the calculation of the time-dependent dipole moment of Ca, Mg and Na2. Our results show trends similar to what was previously observed in model systems or within linear response. In the non-linear domain, our results show that relaxation times do not decrease with increasing deposited excitation energy, which sets some limitations to the practical use of TDCDFT in such a domain of excitations.

  10. Current Characteristics and Trends of the Tracked Satellite Population in the Human Space Flight Regime

    Science.gov (United States)

    Johnson, Nicholas L.

    2006-01-01

    Since the end of the Apollo program in 1972, human space flight has been restricted to altitudes below 600 km above the Earth s surface with most missions restricted to a ceiling below 400 km. An investigation of the tracked satellite population transiting and influencing the human space flight regime during the past 11 years (equivalent to a full solar cycle) has recently been completed. The overall effects of satellite breakups and solar activity are typically less pronounced in the human space flight regime than other regions of low Earth orbit. As of January 2006 nearly 1500 tracked objects resided in or traversed the human space flight regime, although two-thirds of these objects were in orbits of moderate to high eccentricity, significantly reducing their effect on human space flight safety. During the period investigated, the spatial density of tracked objects in the 350-400 km altitude regime of the International Space Station demonstrated a steady decline, actually decreasing by 50% by the end of the period. On the other hand, the region immediately above 600 km experienced a significant increase in its population density. This regime is important for future risk assessments, since this region represents the reservoir of debris which will influence human space flight safety in the future. The paper seeks to put into sharper perspective the risks posed to human space flight by the tracked satellite population, as well as the influences of solar activity and the effects of compliance with orbital debris mitigation guidelines on human space flight missions. Finally, the methods and successes of characterizing the population of smaller debris at human space flight regimes are addressed.

  11. Flow regime, void fraction and interfacial area transport and characteristics of co-current downward two-phase flow

    Energy Technology Data Exchange (ETDEWEB)

    Lokanathan, Manojkumar [School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907-2088 (United States); Hibiki, Takashi [School of Nuclear Engineering, Purdue University, 400 Central Drive, West Lafayette, IN 47907-2017 (United States)

    2016-10-15

    Highlights: • Downward flow regime maps and models were studied for 25.4 to 101.6 mm pipe diameters. • Effect of flow inlet on flow transition, void & interfacial area profile were studied. • Bubble void profiles were associated with the interfacial forces for downward flow. • Flow regime pressure drop and interfacial friction factor were studied. • The most applicable and accurate downward drift-flux correlation was determined. - Abstract: Downward two-phase flow is observed in light water reactor accident scenarios such as loss of coolant accident (LOCA) and loss of heat sink accident (LOHS) due to loss of feed water or a secondary pipe break. Hence, a comprehensive literature review has been performed for the co-current downward two-phase flow with information on the flow regime transitions and flow characteristics for each regime in the downward flow. The review compares the experimental data of the flow regime map and the current available transition models. Objectivity of the data varies on the method utilized as a certain degree of subjectivity is still present in the most objective method. Nevertheless, experimental data through subjective methods such as direct visualization or analysis of a wire mesh sensor (WMS) data were still studied in this review. Despite the wide range of flow regime data for numerous pipe sizes, a consensus was not reached for the effect of pipe sizes on flow regime transition. However, it is known that a larger pipe results in greater degree of coalescence at lower gas flow rates (Hibiki et al., 2004). The introduction of a flow straightener at the inlet led to less coring and fluid rotation and inevitably, reduced bubble coalescence. This also resulted in the disappearance of the kinematic shock wave phenomenon, contrary to an inlet without a flow straightener. The effect of flow inlet, flow location, pipe diameter and bubble interfacial forces on the radial distribution as well as bubble coalescence and breakup rate

  12. Data Integrity-A Study of Current Regulatory Thinking and Action.

    Science.gov (United States)

    Shafiei, Nader; De Montardy, Regis; Rivera-Martinez, Edwin

    2015-01-01

    In reaction to breaches of data integrity in the pharmaceutical industry, regulatory authorities have introduced inspection approaches or initiatives with the aim of reducing occurrences of data integrity problems. This review article-based on study of 65 cases of regulatory action from 2002 to 2014-provides an overview of current regulatory thinking and action on breaches of data integrity affecting GxP (health-related regulations) processes supporting non-clinical studies, clinical studies, laboratory controls, and production controls. These case studies largely represent position of the U.S. Food and Drug Administration and the regulatory agencies affiliated with the European Medicines Agency. Also discussed is the role of human factors as a potential source of data integrity problems. The article concludes by recommending some remedial controls that could be established to avoid or reduce occurrences of data integrity problems.Lay Abstract: In fulfilling their mission to protect public health, regulatory agencies (e.g., U.S. Food and Drug Administration, European Medicines Agency) must establish confidence that medical products they approve are fit for their intended use. In so doing they rely on scientific and operational data generated during research, development, manufacturing, sales, marketing, distribution, and post-marketing surveillance activities. The level of confidence they build is directly proportional to the scientific validity and integrity of data presented to them by the sponsors of medical products. In this article we present analysis of 65 case studies that document regulatory action taken by various regulatory agencies on breach of data integrity between 2002 and 2014. The ensuing discussion on current trends largely represents position of the U.S. Food and Drug Administration and European Medicines Agency. The article concludes by proposing some remedial controls that could be established by pharmaceutical companies to avoid or reduce

  13. High-accuracy current generation in the nanoampere regime from a silicon single-trap electron pump

    Science.gov (United States)

    Yamahata, Gento; Giblin, Stephen P.; Kataoka, Masaya; Karasawa, Takeshi; Fujiwara, Akira

    2017-01-01

    A gigahertz single-electron (SE) pump with a semiconductor charge island is promising for a future quantum current standard. However, high-accuracy current in the nanoampere regime is still difficult to achieve because the performance of SE pumps tends to degrade significantly at frequencies exceeding 1 GHz. Here, we demonstrate robust SE pumping via a single-trap level in silicon up to 7.4 GHz, at which the pumping current exceeds 1 nA. An accuracy test with an uncertainty of about one part per million (ppm) reveals that the pumping current deviates from the ideal value by only about 20 ppm at the flattest part of the current plateau. This value is two orders of magnitude better than the best one reported in the nanoampere regime. In addition, the pumping accuracy is almost unchanged up to 7.4 GHz, probably due to strong electron confinement in the trap. These results indicate that trap-mediated SE pumping is promising for achieving the practical operation of the quantum current standard. PMID:28322339

  14. Prediction of femtosecond oscillations in the transient current of a quantum dot in the Kondo regime

    KAUST Repository

    Goker, A.

    2010-10-11

    We invoke the time-dependent noncrossing approximation in order to study the effects of the density of states of gold contacts on the instantaneous conductance of a single electron transistor which is abruptly moved into the Kondo regime by means of a gate voltage. For an asymmetrically coupled system, we observe that the instantaneous conductance in the Kondo time scale exhibits beating with distinct frequencies, which are proportional to the separation between the Fermi level and the sharp features in the density of states of gold. Increasing the ambient temperature or bias quenches the amplitude of the oscillations. We attribute the oscillations to interference between the emerging Kondo resonance and van-Hove singularities in the density of state. In addition, we propose an experimental realization of this model.

  15. Strategies of bringing drug product marketing applications to meet current regulatory standards.

    Science.gov (United States)

    Wu, Yan; Freed, Anita; Lavrich, David; Raghavachari, Ramesh; Huynh-Ba, Kim; Shah, Ketan; Alasandro, Mark

    2015-08-01

    In the past decade, many guidance documents have been issued through collaboration of global organizations and regulatory authorities. Most of these are applicable to new products, but there is a risk that currently marketed products will not meet the new compliance standards during audits and inspections while companies continue to make changes through the product life cycle for continuous improvement or market demands. This discussion presents different strategies to bringing drug product marketing applications to meet current and emerging standards. It also discusses stability and method designs to meet process validation and global development efforts.

  16. Detecting Current Noise with a Josephson Junction in the Macroscopic Quantum Tunneling Regime

    OpenAIRE

    Peltonen, J. T.; Timofeev, A. V.; Meschke, M.; Pekola, J.P.

    2006-01-01

    We discuss the use of a hysteretic Josephson junction to detect current fluctuations with frequencies below the plasma frequency of the junction. These adiabatic fluctuations are probed by switching measurements observing the noise-affected average rate of macroscopic quantum tunneling of the detector junction out of its zero-voltage state. In a proposed experimental scheme, frequencies of the noise are limited by an on-chip filtering circuit. The third cumulant of current fluctuations at the...

  17. Electrodynamic acceleration of dielectric bodies in a rail gun in the constant current regime

    Science.gov (United States)

    Drobyshevskii, E. M.; Zhukov, B. G.; Nazarov, E. V.; Rozov, S. I.; Sokolov, V. M.; Kurakin, R. O.; Savel'Ev, M. A.; Iuferov, S. V.

    1991-04-01

    Rail gun experiments are reported in which dielectric bodies were accelerated magnetohydrodynamically by a plasma piston to velocities at which the kinetic energy per each atom became comparable with or greater than the chemical bond energy. In the constant current approximation, a simple expression is obtained which unambiguously relates the acceleration path length to the amount of electricity passing through the system, irrespective of the acceleration rate and final velocity of the body. Practically constant accelerations of about 3 x 10 exp 6 g were achieved for polycarbonate projectiles with a linear current density close to the limit of explosive electrode evaporation (about 60 kA/mm)

  18. A new regime of the Agulhas Current Retroflection: Turbulent Choking of Indian-Atlantic leakag

    NARCIS (Netherlands)

    le Bars, D.L.B.|info:eu-repo/dai/nl/326165150; de Ruijter, W.P.M.|info:eu-repo/dai/nl/068476760; Dijkstra, H.A.|info:eu-repo/dai/nl/073504467

    2012-01-01

    An analysis of the Indian Ocean circulation and the Agulhas Current retroflection is carried out using a primitive equation model with simplified coastline and flat bottom. Four configurations with 0.258 and 0.18 horizontal resolution and in barotropic and baroclinic cases are considered. The wind

  19. Current and future fire regimes and their influence on natural vegetation in Ethiopia

    DEFF Research Database (Denmark)

    van Breugel, Paulo; Friis, Ib; Demissew, Sebsebe

    2016-01-01

    employed statistical modeling techniques to estimate the distribution of fire and the PNVs under current climatic conditions, and used the calibrated models to project distributions for different climate change scenarios. Results show a clear congruence between distribution patterns of fire and major...

  20. A new regime of the Agulhas Current Retroflection: Turbulent Choking of Indian-Atlantic leakag

    NARCIS (Netherlands)

    le Bars, D.L.B.; de Ruijter, W.P.M.; Dijkstra, H.A.

    2012-01-01

    An analysis of the Indian Ocean circulation and the Agulhas Current retroflection is carried out using a primitive equation model with simplified coastline and flat bottom. Four configurations with 0.258 and 0.18 horizontal resolution and in barotropic and baroclinic cases are considered. The wind s

  1. A Study on Current Status of Detection Technology and Establishment of National Detection Regime against Nuclear/Radiological Terrorism

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, Sung Woo; Jang, Sung Soon; Lee, Joung Hoon; Yoo, Ho Sik [Korea Institute of Nuclear Non-proliferation and Control, Daejeon (Korea, Republic of)

    2009-09-15

    Since 1990s, some events - detection of a dirty bomb in a Russian nation park in 1995, 9/11 terrorist attack to WTC in 2001, discovery of Al-Qaeda's experimentation to build a dirty bomb in 2003 etc - have showed that nuclear or radiological terrorism relating to radioactive materials (hereinafter 'radioactive materials' is referred to as 'nuclear material, nuclear spent fuel and radioactive source') is not incredible but serious and credible threat. Thus, to respond to the new threat, the international community has not only strengthened security and physical protection of radioactive materials but also established prevention of and response to illicit trafficking of radioactive materials. In this regard, our government has enacted or revised the national regulatory framework with a view to improving security of radioactive materials and joined the international convention or agreement to meet this international trend. For the purpose of prevention of nuclear/radiological terrorism, this paper reviews physical characteristics of nuclear material and existing detection instruments used for prevention of illicit trafficking. Finally, national detection regime against nuclear/radiological terrorism based on paths of the smuggled radioactive materials to terrorist's target building/area, national topography and road networks, and defence-in-depth concept is suggested in this paper. This study should contribute to protect people's health, safety and environment from nuclear/radiological terrorism.

  2. Sub-cycle optical control of current in a semiconductor: from multiphoton to tunneling regime

    CERN Document Server

    Paasch-Colberg, Tim; Sağlam, Özge; Kapser, Stefan; Cabrini, Stefano; Mühlbrandt, Sascha; Reichert, Joachim; Barth, Johannes V; Ernstorfer, Ralph; Kienberger, Reinhard; Yakovlev, Vladislav S; Karpowicz, Nicholas; Schiffrin, Agustin

    2016-01-01

    Nonlinear interactions between ultrashort optical waveforms and solids can be used to induce and steer electric current on a femtosecond (fs) timescale, holding promise for electronic signal processing at PHz frequencies [Nature 493, 70 (2013)]. So far, this approach has been limited to insulators, requiring extremely strong peak electric fields and intensities. Here, we show all-optical generation and control of directly measurable electric current in a semiconductor relevant for high-speed and high-power (opto)electronics, gallium nitride (GaN), within an optical cycle and on a timescale shorter than 2 fs, at intensities at least an order of magnitude lower than those required for dielectrics. Our approach opens the door to PHz electronics and metrology, applicable to low-power (non-amplified) laser pulses, and may lead to future applications in semiconductor and photonic integrated circuit technologies.

  3. Data assimilation in the low noise, accurate observation regime with application to the Kuroshio current

    CERN Document Server

    Vanden-Eijnden, Eric

    2012-01-01

    On-line data assimilation techniques such as ensemble Kalman filters and particle filters tend to loose accuracy dramatically when presented with an unlikely observation. Such an observation may be caused by an unusually large measurement error or reflect a rare fluctuation in the dynamics of the system. Over a long enough span of time it becomes likely that one or several of these events will occur. In some cases they are signatures of the most interesting features of the underlying system and their prediction becomes the primary focus of the data assimilation procedure. The Kuroshio current that runs along the eastern coast of Japan is an example of just such a system. It undergoes infrequent but dramatic changes of state between a small meander during which the current remains close to the coast of Japan, and a large meander during which the current bulges away from the coast. Because of the important role that the Kuroshio plays in distributing heat and salinity in the surrounding region, prediction of th...

  4. Prebiotics and the health benefits of fiber: current regulatory status, future research, and goals.

    Science.gov (United States)

    Brownawell, Amy M; Caers, Wim; Gibson, Glenn R; Kendall, Cyril W C; Lewis, Kara D; Ringel, Yehuda; Slavin, Joanne L

    2012-05-01

    First defined in the mid-1990s, prebiotics, which alter the composition and activity of gastrointestinal (GI) microbiota to improve health and well-being, have generated scientific and consumer interest and regulatory debate. The Life Sciences Research Organization, Inc. (LSRO) held a workshop, Prebiotics and the Health Benefits of Fiber: Future Research and Goals, in February 2011 to assess the current state of the science and the international regulatory environment for prebiotics, identify research gaps, and create a strategy for future research. A developing body of evidence supports a role for prebiotics in reducing the risk and severity of GI infection and inflammation, including diarrhea, inflammatory bowel disease, and ulcerative colitis as well as bowel function disorders, including irritable bowel syndrome. Prebiotics also increase the bioavailability and uptake of minerals and data suggest that they reduce the risk of obesity by promoting satiety and weight loss. Additional research is needed to define the relationship between the consumption of different prebiotics and improvement of human health. New information derived from the characterization of the composition and function of different prebiotics as well as the interactions among and between gut microbiota and the human host would improve our understanding of the effects of prebiotics on health and disease and could assist in surmounting regulatory issues related to prebiotic use.

  5. Zero harmful discharge, regulatory regime, follow-up and results. A proposal for a harmonized system.[Norway

    Energy Technology Data Exchange (ETDEWEB)

    Beck, Hans Jacob; Teigen, Staale; Weltzien, Rune; Moss, Rigmor

    2006-03-15

    The operating companies on the Norwegian Continental Shelf (NCS) have worked according to principles in the zero harmful discharge concepts for more than 5 years. Ecotoxicological information on offshore chemicals is registered in the Chems-R database in the KPD-centre operated by Novatech AS on behalf of the operators on the NCS. The chemicals are classified according to intrinsic properties (acute toxicity, bioaccumulation, biodegradation and combination of these). The color codes/categories are green (PLONOR chemicals), yellow (acceptable), red (environmental harmful) and black (not allowed to use). The system is described in the Regulations, the Activities . The Norwegian Pollution Control Agency (SFT) submits discharge permits with quotas on chemicals of red/black category. These quotas are to be followed-up by the operating companies according to internal control principles. Environmental discharge accounting systems are used to register and report discharges according to the Regulations, the Information Duty. Together with exo toxicological data from Chems-R, a follow-up system is used to detect non-conformances from the allowed quotas. Key Performance Indicators are used as incentives to achieve internal targets. By combining the regulatory systems, the discharge accounting systems, Chems-R information and the follow-up systems it is fairly easy to put a driving force towards zero harmful discharge of chemicals. The discharges of chemicals of red and black category have been reduced by approx. 75 % and 95 % respectively from 1998 to 2003 on the NCS. (Author)

  6. Limits for the graphene on ferroelectric domain wall p-n-junction rectifier for different regimes of current

    Science.gov (United States)

    Strikha, Maksym V.; Morozovska, Anna N.

    2016-12-01

    Here, we present the theory of the conductivity of a pn junction (pnJ) in a graphene channel, placed on a ferroelectric substrate, caused by the ferroelectric domain wall for the case of the arbitrary current regime: from ballistic to diffusive one. We calculated the ratio of the pnJ conductions for opposite polarities of voltages, applied to source and drain electrodes of the channel, G+to t a l /G-to t a l , as a function of graphene channel length L, electron mean free path λ, and ferroelectric substrate permittivity ɛ33f . We have demonstrated that the small values of G+to t a l /G-to t a l (0.1 and smaller), which correspond to the efficient graphene pnJ based rectifier, can be obtained for the ferroelectrics with high ɛ33f≫100 and for the ratios of L/λ ˜ 1 or smaller. However, for ferroelectrics with extremely high ɛ33f (relaxor or PbZrxTi1-xO3 with the composition x near the morphotropic phase boundary x = 0.52), the ratio G+to t a l /G-to t a l can be essentially smaller than unity for the case of a pronounced diffusive regime of current as well. This makes the ferroelectric substrates with high permittivity excellent candidates for the fabrication of new generation of rectifiers based on the graphene pnJ. The temperature effect on the G+to t a l /G-to t a l ratio was studied within the Landau-Ginzburg-Devonshire approach. We have demonstrated that the rectifying properties of the graphene pnJ become better in the vicinity of Curie temperature. However, for the temperatures higher than the Curie temperature, the rectifying effect vanishes due to the ferroelectric polarization disappearance.

  7. On the physical processes ruling an atmospheric pressure air glow discharge operating in an intermediate current regime

    Energy Technology Data Exchange (ETDEWEB)

    Prevosto, L., E-mail: prevosto@waycom.com.ar; Mancinelli, B.; Chamorro, J. C.; Cejas, E. [Grupo de Descargas Eléctricas, Departamento Ing. Electromecánica, Facultad Regional Venado Tuerto (UTN), Laprida 651, Venado Tuerto (2600), Santa Fe (Argentina); Kelly, H. [Grupo de Descargas Eléctricas, Departamento Ing. Electromecánica, Facultad Regional Venado Tuerto (UTN), Laprida 651, Venado Tuerto (2600), Santa Fe (Argentina); Instituto de Física del Plasma (CONICET), Facultad de Ciencias Exactas y Naturales (UBA) Ciudad Universitaria Pab. I, 1428, Buenos Aires (Argentina)

    2015-02-15

    Low-frequency (100 Hz), intermediate-current (50 to 200 mA) glow discharges were experimentally investigated in atmospheric pressure air between blunt copper electrodes. Voltage–current characteristics and images of the discharge for different inter-electrode distances are reported. A cathode-fall voltage close to 360 V and a current density at the cathode surface of about 11 A/cm{sup 2}, both independent of the discharge current, were found. The visible emissive structure of the discharge resembles to that of a typical low-pressure glow, thus suggesting a glow-like electric field distribution in the discharge. A kinetic model for the discharge ionization processes is also presented with the aim of identifying the main physical processes ruling the discharge behavior. The numerical results indicate the presence of a non-equilibrium plasma with rather high gas temperature (above 4000 K) leading to the production of components such as NO, O, and N which are usually absent in low-current glows. Hence, the ionization by electron-impact is replaced by associative ionization, which is independent of the reduced electric field. This leads to a negative current-voltage characteristic curve, in spite of the glow-like features of the discharge. On the other hand, several estimations show that the discharge seems to be stabilized by heat conduction; being thermally stable due to its reduced size. All the quoted results indicate that although this discharge regime might be considered to be close to an arc, it is still a glow discharge as demonstrated by its overall properties, supported also by the presence of thermal non-equilibrium.

  8. How pattern formation in ring networks of excitatory and inhibitoryspiking neurons depends on the input current regime

    Directory of Open Access Journals (Sweden)

    Birgit eKriener

    2014-01-01

    Full Text Available Pattern formation, i.e., the generation of an inhomogeneous spatial activity distribution in a dynamical system with translation invariant structure, is a well-studied phenomenon in neuronal network dynamics,specifically in neural field models. These are population models to describe the spatio-temporal dynamics of large groups of neurons in terms of macroscopic variables such as population firing rates. Though neural field models are often deduced from and equipped with biophysically meaningfulproperties, a direct mapping to simulations of individual spiking neuron populations is rarely considered. Neurons have a distinct identity defined by their action on their postsynaptic targets. In its simplest form they act either excitatorily or inhibitorily.When the distribution of neuron identities is assumed to be periodic, pattern formation can be observed, given the coupling strength is supercritical, i.e., larger than a critical weight. We find that this critical weight is strongly dependent on the characteristics of the neuronal input, i.e., depends on whether neurons are mean- orfluctuation driven, and different limits in linearizing the full non-linear system apply in order to assess stability.In particular, if neurons are mean-driven, the linearization has a very simple form and becomesindependent of both the fixed point firing rate and the variance of the input current, while in the very strongly fluctuation-driven regime the fixed point rate, as well as the input mean and variance areimportant parameters in the determination of the critical weight.We demonstrate that interestingly even in ``intermediate'' regimes, when the system is technically fluctuation-driven, the simple linearization neglecting the variance of the input can yield the better prediction of the critical couplingstrength. We moreover analyze the effects of structural randomness by rewiring individualsynapses or redistributing weights, as well as coarse-graining on pattern

  9. Characterization of plasma electrolytic oxidation coatings on Zircaloy-4 formed in different electrolytes with AC current regime

    Energy Technology Data Exchange (ETDEWEB)

    Cheng Yingliang, E-mail: chengyingliang@hnu.edu.cn [College of Materials Science and Engineering, Hunan University, Changsha 410082 (China); Matykina, Enzhe [Dpt. Ciencia de los Materiales e Ingenieria Metalurgica, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, Madrid 28040 (Spain); Skeldon, Peter; Thompson, George [Corrosion and Protection Centre, School of Materials, University of Manchester, Sackville Street, Manchester M13 9PL (United Kingdom)

    2011-10-01

    Highlights: > ZrO{sub 2} coatings are grown on Zircaloy-4 by AC plasma electrolytic oxidation. > Tetragonal and monoclinic ZrO{sub 2} are formed using silicate electrolyte. > Pyrophosphate electrolyte results in flawed coatings of monoclinic ZrO{sub 2}. > Silicate favours formation of tetragonal ZrO{sub 2}, with coating hardness {approx}8 GPa. > Microstructures are related to temperature gradients and solidification rates. - Abstract: Plasma electrolytic oxidation was undertaken on Zircaloy-4 in alkaline silicate and pyrophosphate electrolytes, with a square waveform AC current regime. The resultant coatings were examined using scanning electron spectroscopy, X-ray diffraction and nanoindentation. The coatings formed in silicate electrolyte comprised mainly a porous inner layer and a more compact outer layer, with characteristic solidification structures being evident following prolonged treatment. The coatings contained monoclinic and tetragonal ZrO{sub 2}, the latter being mainly present in the outer layer, which was of hardness up to {approx}8 GPa. In contrast, extensively cracked coatings resulted from use of pyrophosphate electrolyte; the coating integrity was improved by the addition of silicate to the pyrophosphate electrolyte. The different morphologies of the coatings appeared to be related to the differing nature of the microdischarges and to the incorporation of silicon species that enhanced the formation of t-ZrO{sub 2}.

  10. Current status and regulatory perspective of chimeric antigen receptor-modified T cell therapeutics.

    Science.gov (United States)

    Kim, Mi-Gyeong; Kim, Dongyoon; Suh, Soo-Kyung; Park, Zewon; Choi, Min Joung; Oh, Yu-Kyoung

    2016-04-01

    Chimeric antigen receptor-modified T cells (CAR-T) have emerged as a new modality for cancer immunotherapy due to their potent efficacy against terminal cancers. CAR-Ts are reported to exert higher efficacy than monoclonal antibodies and antibody-drug conjugates, and act via mechanisms distinct from T cell receptor-engineered T cells. These cells are constructed by transducing genes encoding fusion proteins of cancer antigen-recognizing single-chain Fv linked to intracellular signaling domains of T cell receptors. CAR-Ts are classified as first-, second- and third-generation, depending on the intracellular signaling domain number of T cell receptors. This review covers the current status of CAR-T research, including basic proof-of-concept investigations at the cell and animal levels. Currently ongoing clinical trials of CAR-T worldwide are additionally discussed. Owing to the lack of existing approved products, several unresolved concerns remain with regard to safety, efficacy and manufacturing of CAR-T, as well as quality control issues. In particular, the cytokine release syndrome is the major side-effect impeding the successful development of CAR-T in clinical trials. Here, we have addressed the challenges and regulatory perspectives of CAR-T therapy.

  11. Can current moisture responses predict soil CO2 efflux under altered precipitation regimes? A synthesis of manipulation experiments

    Directory of Open Access Journals (Sweden)

    S. Vicca

    2014-01-01

    functions across a broader range of precipitation regimes and soil moisture conditions. Such experiments should make accurate measurements of water availability, they require high-frequency SCE measurements and they should consider both instantaneous responses and the potential legacy effects of climate extremes. This is important, because we demonstrated that at least for some ecosystems, current moisture responses cannot be extrapolated to predict SCE under altered rainfall.

  12. Current Status and Regulatory Aspects of Pesticides Considered to be Persistent Organic Pollutants (POPs) in Taiwan

    Science.gov (United States)

    Tsai, Wen-Tien

    2010-01-01

    Organochlorine pesticides (OCPs) are capable of persisting in the environment, transporting between phase media and accumulating to high levels, implying that they could pose a risk of causing adverse effects to human health and the environment. Consequently, most OCPs are designated as persistent organic pollutants (POPs) and even as endocrine disrupting chemicals (EDCs). The objective of this paper was to review the current status of pesticide POPs in Taiwan, including aldrin, chlordane, chlordecone, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene, α/β-hexachlorocyclohexanes, lindane, mirex, pentachloro-benzene, and toxaphene. The information about their environmental properties, banned use, carcinogenic toxicity and environmental levels, can be connected with the regulatory infrastructure, which has been established by the joint-venture of the central competent authorities (i.e., Environmental Protection Administration, Department of Health, Council of Agriculture, and Council of Labor Affairs). The significant progress to be reported is that the residual levels of these pesticide-POPs, ranging from trace amounts to a few ppb, have declined notably in recent years. PMID:21139852

  13. Drug interaction studies on new drug applications: current situations and regulatory views in Japan.

    Science.gov (United States)

    Nagai, Naomi

    2010-01-01

    Drug interaction studies on new drug applications (NDAs) for new molecular entities (NMEs) approved in Japan between 1997 and 2008 are examined in the Pharmaceuticals and Medical Devices Agency (PMDA). The situations of drug interaction studies in NDAs have changed over the past 12 years, especially in metabolizing enzyme and transporter-based drug interactions. Materials and approaches to study drug-metabolizing enzyme-based drug interactions have improved, and become more rational based on mechanistic theory and new technologies. On the basis of incremental evidence of transporter roles in human pharmacokinetics, transporter-based drug interactions have been increasingly studied during drug development and submitted in recent NDAs. Some recently approved NMEs include transporter-based drug interaction information in their package inserts (PIs). The regulatory document "Methods of Drug Interaction Studies," in addition to recent advances in science and technology, has also contributed to plan and evaluation of drug interaction studies in recent new drug development. This review summarizes current situations and further discussion points on drug interaction studies in NDAs in Japan.

  14. Current Status and Regulatory Aspects of Pesticides Considered to be Persistent Organic Pollutants (POPs in Taiwan

    Directory of Open Access Journals (Sweden)

    Wen-Tien Tsai

    2010-10-01

    Full Text Available Organochlorine pesticides (OCPs are capable of persisting in the environment, transporting between phase media and accumulating to high levels, implying that they could pose a risk of causing adverse effects to human health and the environment. Consequently, most OCPs are designated as persistent organic pollutants (POPs and even as endocrine disrupting chemicals (EDCs. The objective of this paper was to review the current status of pesticide POPs in Taiwan, including aldrin, chlordane, chlordecone, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene, α/β-hexachlorocyclohexanes, lindane, mirex, pentachloro-benzene, and toxaphene. The information about their environmental properties, banned use, carcinogenic toxicity and environmental levels, can be connected with the regulatory infrastructure, which has been established by the joint-venture of the central competent authorities (i.e., Environmental Protection Administration, Department of Health, Council of Agriculture, and Council of Labor Affairs. The significant progress to be reported is that the residual levels of these pesticide-POPs, ranging from trace amounts to a few ppb, have declined notably in recent years.

  15. Sustainable urban regime adjustments

    DEFF Research Database (Denmark)

    Quitzau, Maj-Britt; Jensen, Jens Stissing; Elle, Morten

    2013-01-01

    The endogenous agency that urban governments increasingly portray by making conscious and planned efforts to adjust the regimes they operate within is currently not well captured in transition studies. There is a need to acknowledge the ambiguity of regime enactment at the urban scale. This directs...... attention to the transformative implications of conscious strategic maneuvering by incumbent regime actors, when confronting regime structurations. This article provides insight to processes of regime enactment performed by local governments by applying a flow-oriented perspective on regime dynamics...

  16. Risk assessment of GM trees in the EU: current regulatory framework and guidance

    Directory of Open Access Journals (Sweden)

    Aguilera J

    2013-04-01

    Full Text Available The use of genetically modified organisms - their release into the environment, import, and utilisation as food/feed or food/feed ingredients - is regulated in the European Union (EU. For placing onto the market, current legislations require a comprehensive and science-based risk assessment. This risk assessment (RA is performed by applicants and then evaluated by national authorities in close cooperation with the European Food Safety Authority (EFSA. The EFSA Panel on Genetically Modified Organisms (GMO has published a comprehensive set of guidance documents for applicants and risk assessors for the RA of GM plants (GMP, their products for food and/or feed use, and their cultivation. In those documents, the strategy and the criteria to conduct the assessment are explained, as well as the scientific data to be provided by the applicant. The assessment starts with the molecular characterisation of the GMP. If the GMP or products derived from it are to be consumed, the evaluation of its composition, potential toxicity and/or allergenicity, and nutritional value constitute further cornerstones of the process. The environmental risk assessment (ERA considers biotic and abiotic interactions and the impacts of the management of the GM plant when it is intended for cultivation. In the case of GM trees special emphasis would be placed on assessing their characteristic features such as their longevity, ability to disperse and their ecological significance in a range of environments. The outcome of the assessment is reflected in a published opinion from the EFSA GMO panel that indicates whether the GMP and its products raise any safety issues. This scientific opinion constitutes one of the elements taken into account by the different European regulatory authorities prior to a decision regarding authorisation to commercialise the product.

  17. [Regulatory Program for Medical Devices in Cuba: experiences and current challenges].

    Science.gov (United States)

    Pereira, Dulce María Martínez; Rodríguez, Yadira Álvarez; Valdés, Yamila Cedeño; Ribas, Silvia Delgado

    2016-05-01

    Regulatory control of medical devices in Cuba is conducted through a system based on the Regulatory Program for Medical Devices as a way to ensure the safety, efficacy, and effectiveness of these technologies, which are in use by the National Health System. This program was launched in 1992, when the Regulations for State Evaluation and Registration of Medical Devices were approved. Its successive stages and the merging of regulatory activities for drugs and medical equipment have meant progress toward stronger, more transparent strategies and greater control of industry and the National Health System. Throughout its course the Cuban program has met with challenges and difficulties that it has addressed by drawing on its own experiences. During the new period, the greatest challenges revolve around ensuring that regulatory systems incorporate scientific evaluation, risk levels, maximum rigor through the use of technical standards, and the implementation of international recommendations, together with the application of the ISO 13485 certification scheme, enhanced market monitoring, and classification of medical devices in accordance with their relevance to the country's national health policies. From the regional standpoint, the greatest challenge lies in working toward regulatory convergence. The Collaborating Centre for the Regulation of Health Technologies will support the proposed regulatory strategy and established regional priorities, in particular in connection with the implementation of actions involving medical devices.

  18. E-learning tools for education: regulatory aspects, current applications in radiology and future prospects.

    Science.gov (United States)

    Pinto, A; Selvaggi, S; Sicignano, G; Vollono, E; Iervolino, L; Amato, F; Molinari, A; Grassi, R

    2008-02-01

    E-learning, an abbreviation of electronic learning, indicates the provision of education and training on the Internet or the World Wide Web. The impact of networks and the Internet on radiology is undoubtedly important, as it is for medicine as a whole. The Internet offers numerous advantages compared with other mass media: it provides access to a large amount of information previously known only to individual specialists; it is flexible, permitting the use of images or video; and it allows linking to Web sites on a specific subject, thus contributing to further expand knowledge. Our purpose is to illustrate the regulatory aspects (including Internet copyright laws), current radiological applications and future prospects of e-learning. Our experience with the installation of an e-learning platform is also presented. We performed a PubMed search on the published literature (without time limits) dealing with e-learning tools and applications in the health sector with specific reference to radiology. The search included all study types in the English language with the following key words: e-learning, education, teaching, online exam, radiology and radiologists. The Fiaso study was referred to for the regulatory aspects of e-learning. The application of e-learning to radiology requires the development of a model that involves selecting and creating e-learning platforms, creating and technologically adapting multimedia teaching modules, creating and managing a unified catalogue of teaching modules, planning training actions, defining training pathways and Continuing Education in Medicine (CME) credits, identifying levels of teaching and technological complexity of support tools, sharing an organisational and methodological model, training the trainers, operators' participation and relational devices, providing training, monitoring progress of the activities, and measuring the effectiveness of training. Since 2004, a platform--LiveLearning--has been used at our

  19. Field-driven domain wall motion under a bias current in the creep and flow regimes in Pt/[CoSiB/Pt]N nanowires.

    Science.gov (United States)

    Choi, Y H; Yoshimura, Y; Kim, K-J; Lee, K; Kim, T W; Ono, T; You, C-Y; Jung, M H

    2016-03-31

    The dynamics of magnetic domain wall (DW) in perpendicular magnetic anisotropy Pt/[CoSiB/Pt]N nanowires was studied by measuring the DW velocity under a magnetic field (H) and an electric current (J) in two extreme regimes of DW creep and flow. Two important findings are addressed. One is that the field-driven DW velocity increases with increasing N in the flow regime, whereas the trend is inverted in the creep regime. The other is that the sign of spin current-induced effective field is gradually reversed with increasing N in both DW creep and flow regimes. To reveal the underlying mechanism of new findings, we performed further experiment and micromagnetic simulation, from which we found that the observed phenomena can be explained by the combined effect of the DW anisotropy, Dzyaloshinskii-Moriya interaction, spin-Hall effect, and spin-transfer torques. Our results shed light on the mechanism of DW dynamics in novel amorphous PMA nanowires, so that this work may open a path to utilize the amorphous PMA in emerging DW-based spintronic devices.

  20. Regulatory Impact Assessment: Its Current Status and Development Prospects in Russia

    Directory of Open Access Journals (Sweden)

    A V Minaev

    2011-12-01

    Full Text Available The article examines the procedure of Regulatory Impact Assessment (RIA, which is widely used in developed countries for elaborating and making state-level decisions and is new to Russia. The paper analyzes the origins and essential features of the RIA model applied abroad, reviews major methodological approaches to the preparation of statements on regulatory impact assessment. The study focuses on the Russian RIA model, describing its differences from the foreign analogues; the paper also analyzes the shortcomings of this model. A forecast for the development of RIA in Russia is made by the author.

  1. Non-human primate regulatory T cells: Current biology and implications for transplantation

    NARCIS (Netherlands)

    E.M. Dons (Eefje); G. Raimondi (Giorgio); D.K.C. Cooper (David); A.W. Thomson (Angus)

    2010-01-01

    textabstractRegulatory T cells (Treg) offer potential for improving long-term outcomes in cell and organ transplantation. The non-human primate model is a valuable resource for addressing issues concerning the transfer of Treg therapy to the clinic. Herein, we discuss the properties of non-human pri

  2. A Framework for Organizing Current and Future Electric Utility Regulatory and Business Models

    Energy Technology Data Exchange (ETDEWEB)

    Satchwell, Andrew [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Cappers, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Schwartz, Lisa [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Fadrhonc, Emily Martin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-06-01

    In this report, we will present a descriptive and organizational framework for incremental and fundamental changes to regulatory and utility business models in the context of clean energy public policy goals. We will also discuss the regulated utility's role in providing value-added services that relate to distributed energy resources, identify the "openness" of customer information and utility networks necessary to facilitate change, and discuss the relative risks, and the shifting of risks, for utilities and customers.

  3. Comparison of Current Regulatory Status for Gene-Based Vaccines in the U.S., Europe and Japan

    Directory of Open Access Journals (Sweden)

    Yoshikazu Nakayama

    2015-03-01

    Full Text Available Gene-based vaccines as typified by plasmid DNA vaccines and recombinant viral-vectored vaccines are expected as promising solutions against infectious diseases for which no effective prophylactic vaccines exist such as HIV, dengue virus, Ebola virus and malaria, and for which more improved vaccines are needed such as tuberculosis and influenza virus. Although many preclinical and clinical trials have been conducted to date, no DNA vaccines or recombinant viral-vectored vaccines expressing heterologous antigens for human use have yet been licensed in the U.S., Europe or Japan. In this research, we describe the current regulatory context for gene-based prophylactic vaccines against infectious disease in the U.S., Europe, and Japan. We identify the important considerations, in particular, on the preclinical assessments that would allow these vaccines to proceed to clinical trials, and the differences on the regulatory pathway for the marketing authorization in each region.

  4. Clinical Potential of Regulatory T Cell Therapy in Liver Diseases: An Overview and Current Perspectives

    Science.gov (United States)

    Jeffery, Hannah C.; Braitch, Manjit Kaur; Brown, Solomon; Oo, Ye Htun

    2016-01-01

    The increasing demand for liver transplantation and the decline in donor organs has highlighted the need for alternative novel therapies to prevent chronic active hepatitis, which eventually leads to liver cirrhosis and liver cancer. Liver histology of chronic hepatitis is composed of both effector and regulatory lymphocytes. The human liver contains different subsets of effector lymphocytes that are kept in check by a subpopulation of T cells known as Regulatory T cells (Treg). The balance of effector and regulatory lymphocytes generally determines the outcome of hepatic inflammation: resolution, fulminant hepatitis, or chronic active hepatitis. Thus, maintaining and adjusting this balance is crucial in immunological manipulation of liver diseases. One of the options to restore this balance is to enrich Treg in the liver disease patients. Advances in the knowledge of Treg biology and development of clinical grade isolation reagents, cell sorting equipment, and good manufacturing practice facilities have paved the way to apply Treg cells as a potential therapy to restore peripheral self-tolerance in autoimmune liver diseases (AILD), chronic rejection, and posttransplantation. Past and on-going studies have applied Treg in type-1 diabetes mellitus, systemic lupus erythematosus, graft versus host diseases, and solid organ transplantations. There have not been any new therapies for the AILD for more than three decades; thus, the clinical potential for the application of autologous Treg cell therapy to treat autoimmune liver disease is an attractive and novel option. However, it is fundamental to understand the deep immunology, genetic profiles, biology, homing behavior, and microenvironment of Treg before applying the cells to the patients. PMID:27656181

  5. Clinical potential of regulatory T cell therapy in liver diseases: An overview and current perspectives

    Directory of Open Access Journals (Sweden)

    Hannah Claire Jeffery

    2016-09-01

    Full Text Available The increasing demand for liver transplantation and the decline in donor organs has highlighted the need for alternative novel therapies to prevent chronic active hepatitis, which eventually leads to liver cirrhosis and liver cancer. Liver histology of chronic hepatitis is composed of both effector and regulatory lymphocytes. The human liver contains different subsets of effector lymphocytes, that are kept in check by a subpopulation of T cells known as Regulatory T cells (Treg. The balance of effector and regulatory lymphocytes generally determines the outcome of hepatic inflammation: resolution, fulminant hepatitis or chronic active hepatitis. Thus, maintaining and adjusting this balance is crucial in immunological manipulation of liver diseases. One of the options to restore this balance is to enrich Treg in the liver disease patients.Advances in the knowledge of Treg biology and development of clinical grade isolation reagents, cell sorting equipment and Good Manufacturing Practice (GMP facilities have paved the way to apply Treg cells as a potential therapy to restore peripheral self-tolerance in autoimmune liver diseases, chronic rejection and post-transplantation. Past and on-going studies have applied Treg in type-1 diabetes mellitus, systemic lupus erythematosus, graft versus host diseases (GVHD and solid organ transplantations. There have not been any new therapies for the autoimmune liver diseases for more than three decades; thus the clinical potential for the application of autologous Treg cell therapy to treat autoimmune liver disease is an attractive and novel option. However, it is fundamental to understand the deep immunology, genetic profiles, biology, homing behavior and microenvironment of Treg before applying the cells to the patients.

  6. A Framework for Organizing Current and Future Electric Utility Regulatory and Business Models

    Energy Technology Data Exchange (ETDEWEB)

    Satchwell, Andrew [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Cappers, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Schwartz, Lisa C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Fadrhonc, Emily Martin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-06-01

    Many regulators, utilities, customer groups, and other stakeholders are reevaluating existing regulatory models and the roles and financial implications for electric utilities in the context of today’s environment of increasing distributed energy resource (DER) penetrations, forecasts of significant T&D investment, and relatively flat or negative utility sales growth. When this is coupled with predictions about fewer grid-connected customers (i.e., customer defection), there is growing concern about the potential for serious negative impacts on the regulated utility business model. Among states engaged in these issues, the range of topics under consideration is broad. Most of these states are considering whether approaches that have been applied historically to mitigate the impacts of previous “disruptions” to the regulated utility business model (e.g., energy efficiency) as well as to align utility financial interests with increased adoption of such “disruptive technologies” (e.g., shareholder incentive mechanisms, lost revenue mechanisms) are appropriate and effective in the present context. A handful of states are presently considering more fundamental changes to regulatory models and the role of regulated utilities in the ownership, management, and operation of electric delivery systems (e.g., New York “Reforming the Energy Vision” proceeding).

  7. The late 1980s regime shift in the ecosystem of Tsushima warm current in the Japan/East Sea: Evidence from historical data and possible mechanisms

    Science.gov (United States)

    Tian, Yongjun; Kidokoro, Hideaki; Watanabe, Tatsuro; Iguchi, Naoki

    2008-05-01

    A climatic regime shift, an abrupt change from cooling to warming in the Japan/East Sea (JES), particularly in the Tsushima warm current (TWC) region, occurred in the late 1980s. The ecosystem of the JES responded strongly to the changing thermal regime. Many, but not all biological components of the ecosystem, spanning from plankton to predatory fishes, and including both warm-water pelagic and cold-water demersal species responded to this late 1980s climatic regime shift in the JES. Diatom abundance (cell number) in spring from a monitoring line located in the central part of JES showed decadal variations with a step change from positive to negative anomalies in 1991. Zooplankton biomass in spring and autumn was high in the 1970s, declined during the 1980s, and returned to higher, but quite variable levels during the 1990s. Japanese sardine catch increased after 1974 to its peak level in 1989 and then declined dramatically to 1974 levels by 1997 with step changes in 1979 and 1994. Conversely, catches of other small pelagic species such as Japanese anchovy and common squid, and several higher-trophic fishes, such as yellowtail and tunas increased markedly in the 1990s compared to the early-mid 1980s. Step changes were detected in these pelagic species during 1989-1992. Catch of demersal species (crab, pink shrimp, Pacific cod and walleye pollock) were high during most of the 1970-1980s, but declined at various times in the late 1980s to generally low catches in the 1990s. Detailed analysis of the demersal fish assemblage composition, abundance and distribution indicated a shift in the late 1980s with several years lag in the time of change. Cold-water species (e.g., walleye pollock, Pacific cod) decreased in abundance and the regions in which their abundances remained high became greatly reduced in extent. Conversely, warm-water species (e.g., pointhead flounder, shotted halibut) increased in abundance and/or extended their spatial range (as indicated by trawl

  8. 信用违约互换监管模式与信用风险缓释工具制度完善——对手方风险的防范%On the Regulatory Regimes of CDS and Regulatory Reform of CRM in China --from the Mitigation of Counterparty Risks

    Institute of Scientific and Technical Information of China (English)

    汪镕

    2012-01-01

    U.S., EU and others have been working on the reform of CDS regulatory regimes: the central clearing regime with central counterparty, margin requirement, information repositories, and insurance/quasi-insurance regime. The specifics of CRM regulatory regimes in China are studied so as to analyze their distinctiveness and weakness, especially in the mitigation of counterparty risks. The conclusion is that there is still weakness in the central clearing regime, and the missing compulsory margin requirement would enable the insurance companies to make regulatory arbitrage and would potentially increase the systemic risks. But China has already adopted a leading regime for public information disclosure. The possible measures for Chinese regulatory authorities are as follows: clarify the role of Shanghai Clearing House in CRM transactions other than registration and settlement; encourage central clearing though favorable capital charge; implement compulsory margin requirement and establish the standard of margin requirement and qualified collateral.%比较美国、欧盟等对信用违约互换(CDS)监管的最新动向:集中清算与中央对手方制度、保证金与信息透明要求、保险/准保险监管模式,结合我国信用风险缓释工具(CRM)试点的现有制度,分析在对手方风险防范制度上的差异与不足。具体指出我国集中清算制度上尚有不足;强制保证金制度的缺失不仅使保险机构存在政策套利的空间,还存在引发系统性风险的潜在危险;但在对市场的在信息披露方面,已经走在世界的前列。提出我国需要尽快明确上海清算所在CRM交易中最为主要的在登记、结算外的风险防控功能,通过资本计量的优惠规定等手段鼓励集中清算,制定强制的保证金要求,并严格限定保证金水平、担保品标准。

  9. Can current moisture responses predict soil CO2 efflux under altered precipitation regimes? A synthesis of manipulation experiments

    DEFF Research Database (Denmark)

    Vicca, S.; Bahn, M.; Estiarte, M.

    2014-01-01

    As a key component of the carbon cycle, soil CO2 efflux (SCE) is being increasingly studied to improve our mechanistic understanding of this important carbon flux. Predicting ecosystem responses to climate change often depends on extrapolation of current relationships between ecosystem processes ...

  10. Can current moisture responses predict soil CO2 efflux under altered precipitation regimes? A synthesis of manipulation experiments

    DEFF Research Database (Denmark)

    Vicca, S.; Bahn, M.; Estiarte, M.;

    2014-01-01

    As a key component of the carbon cycle, soil CO2 efflux (SCE) is being increasingly studied to improve our mechanistic understanding of this important carbon flux. Predicting ecosystem responses to climate change often depends on extrapolation of current relationships between ecosystem processes ...

  11. Can current moisture responses predict soil CO2 efflux under altered precipitation regimes? A synthesis of manipulation experiments

    NARCIS (Netherlands)

    Vicca, S.; Bahn, M.; Estiarte, M.; van Loon, E.E.; Vargas, R.; Alberti, G.; Ambus, P.; Arlain, M.A.; Beier, C.; Bentley, L.P.; Borken, W.; Buchmann, N.; Collins, S.L.; De Dato, G.; Dukes, J.S.; Escolar, C.; Fay, P.; Guidolotti, G.; Hanson, P.J.; Kahmen, A.; Kröel-Dulay, G.; Ladreiter-Knauss, T.; Larsen, K.S.; Lellei-Kovacs, E.; Lebrija-Trejos, E.; Maestre, F.T.; Marhan, S.; Marshall, M.; Meir, P.; Miao, Y.; Muhr, J.; Niklaus, P.A.; Ogaya, R.; Peñuelas, J.; Poll, C.; Rustad, L.E.; Savage, K.; Schindlbacher, A.; Schmidt, I.K.; Smith, A.R.; Scotta, E.D.; Suseela, V.; Tietema, A.; Van Gestel, N.; Van Straaten, O.; Wan, S.; Weber, U.; Janssens, I.A.

    2014-01-01

    As a key component of the carbon cycle, soil CO2 efflux (SCE) is being increasingly studied to improve our mechanistic understanding of this important carbon flux. Predicting ecosystem responses to climate change often depends on extrapolation of current relationships between ecosystem processes and

  12. Managing Carbon Regulatory Risk in Utility Resource Planning:Current Practices in the Western United States

    Energy Technology Data Exchange (ETDEWEB)

    Barbose, Galen; Wiser, Ryan; Phadke, Amol; Goldman, Charles

    2008-05-16

    Concerns about global climate change have substantially increased the likelihood that future policy will seek to minimize carbon dioxide emissions. Assuch, even today, electric utilities are making resource planning and investment decisions that consider the possible implications of these future carbon regulations. In this article, we examine the manner in which utilities assess the financial risks associated with future carbon regulations within their long-term resource plans. We base our analysis on a review of the most recent resource plans filed by fifteen electric utilities in the Western United States. Virtually all of these utilities made some effort to quantitatively evaluate the potential cost of future carbon regulations when analyzing alternate supply- and demand-side resource options for meeting customer load. Even without Federal climate regulation in the U.S., the prospect of that regulation is already having an impact on utility decision-making and resource choices. That said, the methods and assumptions used by utilities to analyze carbon regulatory risk, and the impact of that analysis on their choice of a particular resource strategy, vary considerably, revealing a number of opportunities for analytic improvement. Though our review focuses on a subset of U.S. electric utilities, this work holds implications for all electric utilities and energy policymakers who are seeking to minimize the compliance costs associated with future carbon regulations

  13. Managing Carbon Regulatory Risk in Utility Resource Planning: Current Practices in the Western United States

    Energy Technology Data Exchange (ETDEWEB)

    Barbose, Galen; Wiser, Ryan; Phadke, Amol; Goldman, Charles

    2008-07-11

    Concerns about global climate change have substantially increased the likelihood that future policy will seek to minimize carbon dioxide emissions. As such, even today, electric utilities are making resource planning and investment decisions that consider the possible implications of these future carbon regulations. In this article, we examine the manner in which utilities assess the financial risks associated with future carbon regulations within their long-term resource plans. We base our analysis on a review of the most recent resource plans filed by fifteen electric utilities in the Western United States. Virtually all of these utilities made some effort to quantitatively evaluate the potential cost of future carbon regulations when analyzing alternate supply- and demand-side resource options for meeting customer load. Even without Federal climate regulation in the U.S., the prospect of that regulation is already having an impact on utility decision-making and resource choices. That said, the methods and assumptions used by utilities to analyze carbon regulatory risk, and the impact of that analysis on their choice of a particular resource strategy, vary considerably, revealing a number of opportunities for analytic improvement. Though our review focuses on a subset of U.S. electric utilities, this work holds implications for all electric utilities and energy policymakers who are seeking to minimize the compliance costs associated with future carbon regulations.

  14. Studies of challenge in lower hybrid current drive capability at high density regime in experimental advanced superconducting tokamak

    Science.gov (United States)

    Ding, B. J.; Li, M. H.; Li, Y. C.; Wang, M.; Liu, F. K.; Shan, J. F.; Li, J. G.; Wan, B. N.; Wan

    2017-02-01

    Aiming at a fusion reactor, two issues must be solved for the lower hybrid current drive (LHCD), namely good lower hybrid wave (LHW)-plasma coupling and effective current drive at high density. For this goal, efforts have been made to improve LHW-plasma coupling and current drive capability at high density in experimental advanced superconducting tokamak (EAST). LHW-plasma coupling is improved by means of local gas puffing and gas puffing from the electron side is taken as a routine way for EAST to operate with LHCD. Studies of high density experiments suggest that low recycling and high lower hybrid (LH) frequency are preferred for LHCD experiments at high density, consistent with previous results in other machines. With the combination of 2.45 GHz and 4.6 GHz LH waves, a repeatable high confinement mode plasma with maximum density up to 19~\\text{m}-3$ was obtained by LHCD in EAST. In addition, in the first stage of LHCD cyclic operation, an alternative candidate for more economical fusion reactors has been demonstrated in EAST and further work will be continued.

  15. Development of neuroleptic agents: pharmacogenetics and current safety issues of regulatory concern.

    Science.gov (United States)

    Shah, Rashmi

    2002-12-01

    The development of safe and effective new drug treatments for schizophrenia poses a challenging task. This class of drugs is known to be associated with a wide range of serious and troublesome safety problems that include neurological, cardiac, endocrine, and metabolic side effects. Many of these drugs have a narrow therapeutic index and generate metabolites that often have their own unique pharmacological profile different from the parent compound. These features make it imperative that the optimal dose schedules for neuroleptic drugs are carefully characterized. Many of these drugs are metabolized by cytochrome P450 enzymes, which show genetic polymorphism and a bi modal distribution within the population, A significant subset of the population cannot eliminate these drugs as effectively as the majority. This brings an added dimension of complexity in characterizing the dose and individualizing therapy. Many neuroleptic agents are proarrhythmic with an adverse effect on cardiac repolarization. They are prone to prolonging the QT interval and inducing torsade de pointes. Given the potentially fatal outcome of this ventricular tachyarrhythmia, drug development programs need to ensure that the proarrhythmic potential of any new neuroleptic agent is thoroughly explored and its proarrhythmic risk characterized. The clinical use of many of these drugs is further troubled by their high potential for drug-drug interactions. These too need to be adequately investigated during development The approval and the labeling of a new neuroleptic agent require a careful regulatory assessment of its risk/benefit ratio in comparison with the available alternatives. Their safe and effective use in routine clinical practice depends on careful attention to prescribing information, especially the contraindications, precautions, and patient-monitoring requirements.

  16. Relevance of animal studies in regulatory toxicology : current approaches and future opportunities

    NARCIS (Netherlands)

    Sandt, J.J.M. van de; Feron, V.J.

    1996-01-01

    With rapidly increasing knowledge of toxicological processes, the scientific value and relevance of toxicity studies for risk assessment must be re-evaluated. In this paper, it is proposed that the rigid risk evaluation currently required should be replaced by a more flexible, case-by-case approach,

  17. Examining historical and current mixed-severity fire regimes in ponderosa pine and mixed-conifer forests of western North America.

    Science.gov (United States)

    Odion, Dennis C; Hanson, Chad T; Arsenault, André; Baker, William L; Dellasala, Dominick A; Hutto, Richard L; Klenner, Walt; Moritz, Max A; Sherriff, Rosemary L; Veblen, Thomas T; Williams, Mark A

    2014-01-01

    There is widespread concern that fire exclusion has led to an unprecedented threat of uncharacteristically severe fires in ponderosa pine (Pinus ponderosa Dougl. ex. Laws) and mixed-conifer forests of western North America. These extensive montane forests are considered to be adapted to a low/moderate-severity fire regime that maintained stands of relatively old trees. However, there is increasing recognition from landscape-scale assessments that, prior to any significant effects of fire exclusion, fires and forest structure were more variable in these forests. Biota in these forests are also dependent on the resources made available by higher-severity fire. A better understanding of historical fire regimes in the ponderosa pine and mixed-conifer forests of western North America is therefore needed to define reference conditions and help maintain characteristic ecological diversity of these systems. We compiled landscape-scale evidence of historical fire severity patterns in the ponderosa pine and mixed-conifer forests from published literature sources and stand ages available from the Forest Inventory and Analysis program in the USA. The consensus from this evidence is that the traditional reference conditions of low-severity fire regimes are inaccurate for most forests of western North America. Instead, most forests appear to have been characterized by mixed-severity fire that included ecologically significant amounts of weather-driven, high-severity fire. Diverse forests in different stages of succession, with a high proportion in relatively young stages, occurred prior to fire exclusion. Over the past century, successional diversity created by fire decreased. Our findings suggest that ecological management goals that incorporate successional diversity created by fire may support characteristic biodiversity, whereas current attempts to "restore" forests to open, low-severity fire conditions may not align with historical reference conditions in most ponderosa

  18. Examining historical and current mixed-severity fire regimes in ponderosa pine and mixed-conifer forests of western North America.

    Directory of Open Access Journals (Sweden)

    Dennis C Odion

    Full Text Available There is widespread concern that fire exclusion has led to an unprecedented threat of uncharacteristically severe fires in ponderosa pine (Pinus ponderosa Dougl. ex. Laws and mixed-conifer forests of western North America. These extensive montane forests are considered to be adapted to a low/moderate-severity fire regime that maintained stands of relatively old trees. However, there is increasing recognition from landscape-scale assessments that, prior to any significant effects of fire exclusion, fires and forest structure were more variable in these forests. Biota in these forests are also dependent on the resources made available by higher-severity fire. A better understanding of historical fire regimes in the ponderosa pine and mixed-conifer forests of western North America is therefore needed to define reference conditions and help maintain characteristic ecological diversity of these systems. We compiled landscape-scale evidence of historical fire severity patterns in the ponderosa pine and mixed-conifer forests from published literature sources and stand ages available from the Forest Inventory and Analysis program in the USA. The consensus from this evidence is that the traditional reference conditions of low-severity fire regimes are inaccurate for most forests of western North America. Instead, most forests appear to have been characterized by mixed-severity fire that included ecologically significant amounts of weather-driven, high-severity fire. Diverse forests in different stages of succession, with a high proportion in relatively young stages, occurred prior to fire exclusion. Over the past century, successional diversity created by fire decreased. Our findings suggest that ecological management goals that incorporate successional diversity created by fire may support characteristic biodiversity, whereas current attempts to "restore" forests to open, low-severity fire conditions may not align with historical reference conditions in

  19. Macroeconomic regimes

    NARCIS (Netherlands)

    Baele, L.T.M.; Bekaert, G.R.J.; Cho, S.; Inghelbrecht, K.; Moreno, A.

    2015-01-01

    A New-Keynesian macro-model is estimated accommodating regime-switching behavior in monetary policy and macro-shocks. A key to our estimation strategy is the use of survey-based expectations for inflation and output. Output and inflation shocks shift to the low volatility regime around 1985 and 1990

  20. The historical disturbance regime of mountain Norway spruce forests in the Western Carpathians and its influence on current forest structure and composition.

    Science.gov (United States)

    Janda, Pavel; Trotsiuk, Volodymyr; Mikoláš, Martin; Bače, Radek; Nagel, Thomas A; Seidl, Rupert; Seedre, Meelis; Morrissey, Robert C; Kucbel, Stanislav; Jaloviar, Peter; Jasík, Marián; Vysoký, Juraj; Šamonil, Pavel; Čada, Vojtěch; Mrhalová, Hana; Lábusová, Jana; Nováková, Markéta H; Rydval, Miloš; Matějů, Lenka; Svoboda, Miroslav

    2017-03-15

    In order to gauge ongoing and future changes to disturbance regimes, it is necessary to establish a solid baseline of historic disturbance patterns against which to evaluate these changes. Further, understanding how forest structure and composition respond to variation in past disturbances may provide insight into future resilience to climate-driven alterations of disturbance regimes. We established 184 plots (mostly 1000 m(2)) in 14 primary mountain Norway spruce forests in the Western Carpathians. On each plot we surveyed live and dead trees and regeneration, and cored around 25 canopy trees. Disturbance history was reconstructed by examining individual tree growth trends. The study plots were further aggregated into five groups based on disturbance history (severity and timing) to evaluate and explain its influence on forest structure. These ecosystems are characterized by a mixed severity disturbance regime with high spatiotemporal variability in severity and frequency. However, periods of synchrony in disturbance activity were also found. Specifically, a peak of canopy disturbance was found for the mid-19th century across the region (about 60% of trees established), with the most important periods of disturbance in the 1820s and from the 1840s to the 1870s. Current stand size and age structure were strongly influenced by past disturbance activity. In contrast, past disturbances did not have a significant effect on current tree density, the amount of coarse woody debris, and regeneration. High mean densities of regeneration with height >50 cm (about 1400 individuals per ha) were observed. Extensive high severity disturbances have recently affected Central European forests, spurring a discussion about the causes and consequences. We found some evidence that forests in the Western Carpathians were predisposed to recent severe disturbance events as a result of synchronized past disturbance activity, which partly homogenized size and age structure and made recent

  1. Training in clinical forensic medicine in the UK--perceptions of current regulatory standards.

    Science.gov (United States)

    Stark, Margaret M; Norfolk, Guy A

    2011-08-01

    As clinical forensic medicine (CFM) is not currently recognised as a speciality in the UK there are no nationally agreed mandatory standards for training forensic physicians in either general forensic (GFM) or sexual offence medicine (SOM). The General Medical Council (GMC), the medical regulator in the UK, has issued clear standards for training in all specialities recommending that "trainees must be supported to acquire the necessary skills and experience through induction, effective educational supervision, an appropriate workload and time to learn". In order to evaluate the current situation in the field of clinical forensic medicine, doctors who have recently (within the last two years) started working in the field "trainees" (n = 38), and trainers (n = 61) with responsibility for clinical and educational supervision of new trainees, were surveyed by questionnaire to gather their perceptions of how the relevant GMC standards are being met in initial on-the-job training. Telephone interviews were performed with eleven doctors working as clinical or medical directors to determine their views. It is clear that currently the quality of training in CFM is sub-standard and inconsistent and that the published standards, as to the minimum requirement for training that must be met by post-graduate medical and training providers at all levels, are not being met. The Faculty of Forensic and Legal Medicine (FFLM) needs to set explicit minimum standards which will comply with the regulator and work to pilot credentialing for forensic physicians. A number of recommendations are made for urgent FFLM development.

  2. Use of Biosensors as Alternatives to Current Regulatory Methods for Marine Biotoxins

    Directory of Open Access Journals (Sweden)

    Luis M. Botana

    2009-11-01

    Full Text Available Marine toxins are currently monitored by means of a bioassay that requires the use of many mice, which poses a technical and ethical problem in many countries. With the exception of domoic acid, there is a legal requirement for the presence of other toxins (yessotoxin, saxitoxin and analogs, okadaic acid and analogs, pectenotoxins and azaspiracids in seafood to be controlled by bioassay, but other toxins, such as palytoxin, cyclic imines, ciguatera and tetrodotoxin are potentially present in European food and there are no legal requirements or technical approaches available to identify their presence. The need for alternative methods to the bioassay is clearly important, and biosensors have become in recent years a feasible alternative to animal sacrifice. This review will discuss the advantages and disadvantages of using biosensors as alternatives to animal assays for marine toxins, with particular focus on surface plasmon resonance (SPR technology.

  3. Regionalism versus integration of the EU electricity market : An open debate from the comparative and prospective analysis of regulatory regimes in the central European countries

    Energy Technology Data Exchange (ETDEWEB)

    Engoian, Alda; Mouchart, Christel

    2005-12-15

    The failure of integration of 25 national energy markets into an unique one has been clearly expressed by the European Commission in its last benchmarking report. This working paper investigate the question of the more appropriate and realistic market design to limit perverse effects linked to the gaps between Western and Eastern European electricity markets. The paper consists in comparing electricity regulations per segment of the value chain in the CECs (Czech Republic, Hungary, Poland, Slovakia) characterized by industrial structures stemming from the socialism. Our regulatory approach and the example of South-East Europe support the idea of regionalism as an interim stage towards a final integrated European market. This regionalism based on the Standard Market Design concept, with flexible principles, and simultaneously combined to national reforms would seem to be a ''key of success''. (Author)

  4. Current-voltage characteristics of quantum-point contacts in the closed-channel regime: Transforming the bias voltage into an energy scale

    DEFF Research Database (Denmark)

    Gloos, K.; Utko, P.; Aagesen, M.;

    2006-01-01

    We investigate the I(V) characteristics (current versus bias voltage) of side-gated quantum-point contacts, defined in GaAs/AlxGa1-xAs heterostructures. These point contacts are operated in the closed-channel regime, that is, at fixed gate voltages below zero-bias pinch-off for conductance. Our...... analysis is based on a single scaling factor, extracted from the experimental I(V) characteristics. For both polarities, this scaling factor transforms the change of bias voltage into a change of electron energy. The latter is determined with respect to the top of the potential barrier of the contact....... Such a built-in energy-voltage calibration allows us to distinguish between the different contributions to the electron transport across the pinched-off contact due to thermal activation or quantum tunneling. The first involves the height of the barrier, and the latter also its length. In the model that we...

  5. Delegation, Presidential Regimes, and Latin American Regulatory Agencies Delegación, regimenes presidenciales y agencias reguladoras en América Latina

    Directory of Open Access Journals (Sweden)

    Jacint Jordana

    2010-04-01

    Full Text Available During the 1990s, a large number of regulatory agencies were created or reformed in different sectors in Latin American countries. Almost all included political delegation mechanisms, intended as formal rules to enhance credible commitments to time-consistent policies. In this paper, using an original data set of agencies’ head tenure in the telecommunications and finance regulatory agencies, we discuss if these mechanisms worked as planned, and find a divergence between actual mandates and the formally established fixed terms, effected by means of systematic early resignations. Our findings reveal, however, some consistent patterns of behavior. Stronger legislative presidential power reduced effective delegation to some extent, and agencies’ organizational strengths protected them from patron-age. We also confirmed the existence of some significant differences be-tween the two sectors examined. Having slightly weaker delegation rules, delegation practices were also less effective in telecommunications than in financial services, contrary to expectations about credible commitments. Durante los años 1990, muchas agencias reguladoras fueron creadas o reformadas en diferentes sectores en los países latinoamericanos. Casi todas incluyeron mecanismos de delegación política, entendidos como reglas formales para mejorar los compromisos creíbles sobre políticas que requieren coherencia en el tiempo. En este trabajo, utilizando un conjunto de datos originales sobre los responsables de las agencias reguladoras de las telecomunicaciones y de las finanzas, se discute si estos mecanismos funcionaron como estaba previsto, identificándose una divergencia entre los mandatos reales y los términos formalmente establecidos, debido a la existencia de numerosas renuncias anticipadas. Nuestros hallazgos revelan, sin embargo, algunos patrones consistentes de comportamiento: un mayor poder presidencial sobre el legislativo reduce la delegación efectiva

  6. Regimes internacionais

    OpenAIRE

    Meireles, André Bezerra

    2004-01-01

    Dissertação (mestraddo) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas. Programa de Pós-Graduação em Direito. Qual o papel dos regimes internacionais com relação ao comportamento dos agentes das relações internacionais contemporâneas, em especial, o Estado? Dentro das negociações de uma esfera internacional caracterizada por uma forte interdependência econômica, verificada a existência de múltiplos canais de conexões entre as sociedades, e uma tendência contínua p...

  7. Time-resolved magneto-optical imaging of Y{sub 1}Ba{sub 2}Cu{sub 3}O{sub 7-{delta}} thin films in high-frequency AC current regime

    Energy Technology Data Exchange (ETDEWEB)

    Lucarelli, A [Department of Applied Science, College of William and Mary, Williamsburg, VA 23187-8795 (United States); Luepke, G [Department of Applied Science, College of William and Mary, Williamsburg, VA 23187-8795 (United States); Haugan, T J [Air Force Research Laboratory, Wright-Patterson AFB, OH 45433-7919 (United States); Levin, G A [Air Force Research Laboratory, Wright-Patterson AFB, OH 45433-7919 (United States); Barnes, P N [Air Force Research Laboratory, Wright-Patterson AFB, OH 45433-7919 (United States)

    2006-06-15

    We present a time-resolved magneto-optical (MO) imaging study of high-temperature superconductor (HTS) in a high-frequency alternating current (AC) regime. The evolution of the magnetic flux density distribution in YBa{sub 2}Cu{sub 3}O{sub 7-{delta}} (YBCO) thin film samples is studied as a function of the phase of the applied AC current. A quantitative analysis of the data shows that the maxima of the AC current density is shifted from the edges further inside the sample, which may be caused by the higher self-induced field in that region. This technique can be used to study magnetic flux evolution in HTS films and coated conductors in the high-frequency current regime.

  8. World Nonproliferation Regime

    Institute of Scientific and Technical Information of China (English)

    Ouyang Liping; Wu Xingzuo

    2007-01-01

    2006 witnessed an intense struggle between nuclear proliferation and nonproliferation. Iran's nuclear issue and North Korea's nuclear test have cast a deep shadow over the current international nonproliferation regime. The international contest for civil nuclear development became especially fierce as global energy prices went up. Such a situation , to some extent, accelerated the pace of nuclear proliferation. Furthermore, the existing international nonproliferation regime, based upon the Nuclear Nonproliferation Treaty (NPT), was affected by loopholes, and the U.S. failed in its ambition to unite other forces to mend fences. The international community needs to come up with a comprehensive and long-term strategy to meet the demand for an effective future nonproliferation regime in a healthy nuclear order.

  9. Implementation workshop of WHO guidelines on evaluation of malaria vaccines: Current regulatory concepts and issues related to vaccine quality, Pretoria, South Africa 07 Nov 2014.

    Science.gov (United States)

    Ho, Mei Mei; Baca-Estrada, Maria; Conrad, Christoph; Karikari-Boateng, Eric; Kang, Hye-Na

    2015-08-26

    The current World Health Organization (WHO) guidelines on the quality, safety and efficacy of recombinant malaria vaccines targeting the pre-erythrocytic and blood stages of Plasmodium falciparum were adopted by the WHO Expert Committee on Biological Standardization in 2012 to provide guidance on the quality, nonclinical and clinical aspects of recombinant malaria vaccines. A WHO workshop was organised to facilitate implementation into African (national/regional) regulatory practices, of the regulatory evaluation principles outlined in the guidelines regarding quality aspects. The workshop was used also to share knowledge and experience on regulatory topics of chemistry, manufacturing and control with a focus on vaccines through presentations and an interactive discussion using a case study approach. The basic principles and concepts of vaccine quality including consistency of production, quality control and manufacturing process were presented and discussed in the meeting. By reviewing and practicing a case study, better understanding on the relationship between consistency of production and batch release tests of an adjuvanted pre-erythrocytic recombinant malaria vaccine was reached. The case study exercise was considered very useful to understand regulatory evaluation principles of vaccines and a suggestion was made to WHO to provide such practices also through its Global Learning Opportunities for Vaccine Quality programme.

  10. Limits of the current EU regulatory framework on GMOs: risk of not authorized GM event-traces in imports

    Directory of Open Access Journals (Sweden)

    Roïz Julie

    2014-11-01

    Full Text Available Since their first commercialization in the 1990’s, the number of genetically modified organisms (GMOs cultivated around the world has steadily increased. This development has been accompanied by the development of regulatory and policy environments which vary from one country to another. Today, the European food and feed sectors are faced with the increasing risk of finding traces of not authorized GMOs in imports. Under the EU zero tolerance for unapproved GMOs, this situation may lead to trade disruptions with important cost implications. A regulatory environment which minimizes the risk of such disruption is therefore indispensable. To address this issue, the EU has adopted the “technical solution” but this remains insufficient to provide the necessary legal certainty which is needed to operate in such context. More comprehensive approaches are considered globally through low level presence policies.

  11. Highly Reliable Organizations in the Onshore Natural Gas Sector: An Assessment of Current Practices, Regulatory Frameworks, and Select Case Studies

    Energy Technology Data Exchange (ETDEWEB)

    Logan, Jeffrey S. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Paranhos, Elizabeth [Energy Innovation Partners, Seattle, WA (United States); Kozak, Tracy G. [Energy Innovation Partners, Seattle, WA (United States); Boyd, William [Univ. of Colorado, Boulder, CO (United States)

    2017-07-31

    This study focuses on onshore natural gas operations and examines the extent to which oil and gas firms have embraced certain organizational characteristics that lead to 'high reliability' - understood here as strong safety and reliability records over extended periods of operation. The key questions that motivated this study include whether onshore oil and gas firms engaged in exploration and production (E&P) and midstream (i.e., natural gas transmission and storage) are implementing practices characteristic of high reliability organizations (HROs) and the extent to which any such practices are being driven by industry innovations and standards and/or regulatory requirements.

  12. Modeling of an eddy-current ferrite-cored probe response in time harmonic regime; Modelisation de la reponse d'un capteur a courants de Foucault comportant un noyau ferromagnetique en regime harmonique

    Energy Technology Data Exchange (ETDEWEB)

    Buvat, F

    2005-07-01

    In aeronautics, non destructive evaluation by eddy-current is commonly used to detect corrosion area or cracks in structures. Eddy-current testing by using ferrite-cored probes is effective to detect these kind of defects. So, having a model able to predict these probes responses is a major endeavor. Our work consisted in developing a model determining the ferrite-cored probes response to a defect. To model fields inside both the core and the defect, an integral formulation has been used resulting from the application of the Green theorem onto the equations of propagation. Simulation results have been compared to synthetic data obtained by a finite-element method and they have been validated by comparison with measured impedance data. However as this model may be computationally costly, the use of the so-called non-linear approximation has been tested to tackle the case of long defects. The model has been integrated inside the CIVA platform developed by the CEA. (author)

  13. Regulatory approaches to obesity prevention: A systematic overview of current laws addressing diet-related risk factors in the European Union and the United States.

    Science.gov (United States)

    Sisnowski, Jana; Handsley, Elizabeth; Street, Jackie M

    2015-06-01

    High prevalence of overweight and obesity remains a significant international public health problem. Law has been identified as a tool for obesity prevention and selected high-profile measures have been reported. However, the nature and extent of enacted legislation internationally are unclear. This research provides an overview of regulatory approaches enacted in the United States, the European Union, and EU Member States since 2004. To this end, relevant databases of primary and secondary legislation were systematically searched to identify and explore laws addressing dietary risk factors for obesity. Across jurisdictions, current regulatory approaches to obesity prevention are limited in reach and scope. Target groups are rarely the general population, but instead sub-populations in government-supported settings. Consumer information provision is preferred over taxation and marketing restrictions other than the regulation of health and nutrition claims. In the EU in particular, product reformulation with industry consent has also emerged as a popular small-scale measure. While consistent and widespread use of law is lacking, governments have employed a range of regulatory measures in the name of obesity prevention, indicating that there is, in principle, political will. Results from this study may serve as a starting point for future research and policy development. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  14. Regulatory T cells as a therapeutic tool to induce solid-organ transplant tolerance: current clinical experiences.

    Science.gov (United States)

    Nikoueinejad, Hassan; Sharif, Mohammad Reza; Amirzargar, Aliakbar; Mirshafiey, Abbas; Einollahi, Behzad

    2013-10-01

    Long-term tolerance is potentially an ideal in organ transplant. Achieving this leads us to eliminate immunosuppressive therapies and their associated side effects. Although most succession in this field belongs to mixed chimerism methods of tolerance induction, regulatory T cells and (T-reg)-based methods also have been demonstrated to prevent organ rejection and lead to transplant tolerance through different mechanisms. In contrast to chimeric protocols (which require bone marrow transplant), T-reg-mediated protocols do not aggressively manipulate blood and the immune system. Most treatment has been done for graft-versus-host disease after hematopoietic stem cell transplant. This review describes different types and mechanisms of action and clinical strategies using T-regs to induce transplant tolerance.

  15. Adipose-Derived Stem Cells in Aesthetic Surgery: A Mixed Methods Evaluation of the Current Clinical Trial, Intellectual Property, and Regulatory Landscape.

    Science.gov (United States)

    Arshad, Zeeshaan; Halioua-Haubold, Celine-Lea; Roberts, Mackenna; Urso-Baiarda, Fulvio; Branford, Oliver A; Brindley, David A; Davies, Benjamin M; Pettitt, David

    2017-06-07

    Adipose tissue, which can be readily harvested via a number of liposuction techniques, offers an easily accessible and abundant source of adipose-derived stem cells (ASCs). Consequently, ASCs have become an increasingly popular reconstructive option and a novel means of aesthetic soft tissue augmentation. This paper examines recent advances in the aesthetic surgery field, extending beyond traditional review formats to incorporate a comprehensive analysis of current clinical trials, adoption status, and the commercialization pathway. Keyword searches were carried out on clinical trial databases to search for trials using ASCs for aesthetic indications. An intellectual property landscape was created using commercial software (Thomson Reuters Thomson Innovation, New York, NY). Analysis of who is claiming what in respect of ASC use in aesthetic surgery for commercial purposes was analyzed by reviewing the patent landscape in relation to these techniques. Key international regulatory guidelines were also summarized. Completed clinical trials lacked robust controls, employed small sample sizes, and lacked long-term follow-up data. Ongoing clinical trials still do not address such issues. In recent years, claims to intellectual property ownership have increased in the "aesthetic stem cell" domain, reflecting commercial interest in the area. However, significant translational barriers remain including regulatory challenges and ethical considerations. Further rigorous randomized controlled trials are required to delineate long-term clinical efficacy and safety. Providers should consider the introduction of patient reported outcome metrics to facilitate clinical adoption. Robust regulatory and ethical policies concerning stem cells and aesthetic surgery should be devised to discourage further growth of "stem cell tourism."

  16. Integrating Environmental and International Strategies in a World of Regulatory Turbulence

    NARCIS (Netherlands)

    F.H. Wijen (Frank); R.J.M. van Tulder (Rob)

    2011-01-01

    textabstractSUMMARY Companies operating in multiple countries face different and often changing regimes of environmental regulation. This regulatory turbulence raises the question of what environmental strategies multinational enterprises with a portfolio of divergent regulatory regimes should

  17. Integrating Environmental and International Strategies in a World of Regulatory Turbulence

    NARCIS (Netherlands)

    F.H. Wijen (Frank); R.J.M. van Tulder (Rob)

    2011-01-01

    textabstractSUMMARY Companies operating in multiple countries face different and often changing regimes of environmental regulation. This regulatory turbulence raises the question of what environmental strategies multinational enterprises with a portfolio of divergent regulatory regimes should devel

  18. Regulatory Considerations for the Clinical and Research Use of Transcranial Direct Current Stimulation (tDCS): review and recommendations from an expert panel

    Science.gov (United States)

    Fregni, F; Nitsche, MA; Loo, C.K.; Brunoni, AR; Marangolo, P; Leite, J; Carvalho, S; Bolognini, N; Caumo, W; Paik, NJ; Simis, M; Ueda, K; Ekhitari, H; Luu, P; Tucker, DM; Tyler, WJ; Brunelin, J; Datta, A; Juan, CH; Venkatasubramanian, G; Boggio, PS; Bikson, M

    2014-01-01

    The field of transcranial electrical stimulation (tES) has experienced significant growth in the past 15 years. One of the tES techniques leading this increased interest is transcranial direct current stimulation (tDCS). Significant research efforts have been devoted to determining the clinical potential of tDCS in humans. Despite the promising results obtained with tDCS in basic and clinical neuroscience, further progress has been impeded by a lack of clarity on international regulatory pathways. We therefore convened a group of research and clinician experts on tDCS to review the research and clinical use of tDCS. In this report, we review the regulatory status of tDCS, and we summarize the results according to research, off-label and compassionate use of tDCS in the following countries: Australia, Brazil, France, Germany, India, Iran, Italy, Portugal, South Korea, Taiwan and United States. Research use, off label treatment and compassionate use of tDCS are employed in most of the countries reviewed in this study. It is critical that a global or local effort is organized to pursue definite evidence to either approve and regulate or restrict the use of tDCS in clinical practice on the basis of adequate randomized controlled treatment trials. PMID:25983531

  19. Time-Resolved Magneto-Optical Imaging of Y1Ba2Cu3O7-delta Thin Films in High-Frequency AC Current Regime (Postprint)

    Science.gov (United States)

    2012-02-01

    ΘF=αB laser pulseAC time φ Figure 1. Schematic diagram of the time-resolved MO imaging setup. time-resolved imaging, we use a Q- switched Nd:YLF diode...controlled power source in order to obtain time-resolved MO images of the current flow in the sample. We use a 6 µm thick epitaxial grown ferrite ...the AC current. Ultimately the time resolution achievable with this method will be limited to sub-nanoseconds by the magnetization switching time of the

  20. PROACTIVE REGULATORY INTERVENTION IN EU COMMUNICATIONS SECTOR AND ITS FORESEEABLE FUTURE

    Directory of Open Access Journals (Sweden)

    Mantas Barčys

    2013-06-01

    Full Text Available Purpose – to review and provide insights on the issues concerning ex ante regulatory approach in EU telecommunications (hereinafter – electronic communications industry, identify and emphasise benefits, main challenges and further regulatory prospective. Design/methodology/approach – based on current regulatory framework and analysis of academic literature, author discusses problematic issues related to the needs and further perspectives of proactive regulatory regime in EU electronic communications sector. Findings – the author reviews special qualities for different regulatory regimes (ex ante, ex post and examines them in the context of sharp developments of the industry and EU regulatory policy. Research limitations/implications –the analysis aims to convey the main understanding on the regulatory specifics of the communications industry, the main features, distinguishing communications industry from the others and foreseeable regulatory perspectives Practical implications – the core aspect of the paper is to evaluate current regulatory approach of the EU electronic communications sector and assess potential regulatory approaches in the context of making self-sustaining pro-competitive market structure, technological development. Originality/Value – the paper highlights some significant changes between two regulatory approaches in the light of specific features in EU electronic communications. Author provides his insights on the status and perspectives on application for both regulatory methods. Apparently, these issues have so far been subjected too little academic analysis. As shown in this paper, regulatory policy can have the essential impact on the activities taken by other players. The decision to give an even bigger role to competition rules, do not mean to eliminate sector specifics itself. With this in mind, EU legislators are not able to eliminate proactive regulatory control, thus reducing ex ante rules progressively

  1. Regulatory agencies and regulatory risk

    OpenAIRE

    Knieps, Günter; Weiß, Hans-Jörg

    2007-01-01

    The aim of this paper is to show that regulatory risk is due to the discretionary behaviour of regulatory agencies, caused by a too extensive regulatory mandate provided by the legislator. The normative point of reference and a behavioural model of regulatory agencies based on the positive theory of regulation are presented. Regulatory risk with regard to the future behaviour of regulatory agencies is modelled as the consequence of the ex ante uncertainty about the relative influence of inter...

  2. Z-pinch driven hohlraums design for the 100 nanoseconds current time scale; Conception de cavites radiatives chauffees par plasma de striction magnetique en regime 100ns

    Energy Technology Data Exchange (ETDEWEB)

    Hamann, F

    2003-12-15

    This work estimates Z-pinch driven hohlraums capabilities to obtain high temperatures (>200 eV). Simple models are proposed to calculate the performances offered by currents of 5 to 100 MA in 100 ns. The one dimensional physics of the Z-pinch at the length scale of its thickness and the hydrodynamics instabilities are studied. Then the enhancement of hohlraums performances with double nested Z-pinches or the use of an axial magnetic field is analysed. Z-pinch direct drive approach for inertial confinement fusion is finally considered. All the presented results are based on theoretical and 2D numerical approach and on the analysis of experimental results which were obtained on the american 'Z' generator. Annexes recall radiation MHD equations and check their validity for Z-pinch implosion. (author)

  3. Single-Session Transcranial Direct Current Stimulation Temporarily Improves Symptoms, Mood, and Self-Regulatory Control in Bulimia Nervosa: A Randomised Controlled Trial.

    Science.gov (United States)

    Kekic, Maria; McClelland, Jessica; Bartholdy, Savani; Boysen, Elena; Musiat, Peter; Dalton, Bethan; Tiza, Meyzi; David, Anthony S; Campbell, Iain C; Schmidt, Ulrike

    2017-01-01

    Evidence suggests that pathological eating behaviours in bulimia nervosa (BN) are underpinned by alterations in reward processing and self-regulatory control, and by functional changes in neurocircuitry encompassing the dorsolateral prefrontal cortex (DLPFC). Manipulation of this region with transcranial direct current stimulation (tDCS) may therefore alleviate symptoms of the disorder. This double-blind sham-controlled proof-of-principle trial investigated the effects of bilateral tDCS over the DLPFC in adults with BN. Thirty-nine participants (two males) received three sessions of tDCS in a randomised and counterbalanced order: anode right/cathode left (AR/CL), anode left/cathode right (AL/CR), and sham. A battery of psychological/neurocognitive measures was completed before and after each session and the frequency of bulimic behaviours during the following 24-hours was recorded. AR/CL tDCS reduced eating disorder cognitions (indexed by the Mizes Eating Disorder Cognitions Questionnaire-Revised) when compared to AL/CR and sham tDCS. Both active conditions suppressed the self-reported urge to binge-eat and increased self-regulatory control during a temporal discounting task. Compared to sham stimulation, mood (assessed with the Profile of Mood States) improved after AR/CL but not AL/CR tDCS. Lastly, the three tDCS sessions had comparable effects on the wanting/liking of food and on bulimic behaviours during the 24 hours post-stimulation. These data suggest that single-session tDCS transiently improves symptoms of BN. They also help to elucidate possible mechanisms of action and highlight the importance of selecting the optimal electrode montage. Multi-session trials are needed to determine whether tDCS has potential for development as a treatment for adult BN.

  4. Mineralogy of Holocene Sediments from the Southwestern Black Sea Shelf (Turkey) in Relation to Provenance, Sea-level and Current Regimes

    Institute of Scientific and Technical Information of China (English)

    Emel BAYHAN; Mustafa ERG(I)N; Abidin TEMEL; Seref KESK(I)N

    2005-01-01

    Grain size and mineral composition of core sediments were used to investigate influences of various terrestrial and marine conditions,which have prevailed on the southwestern Black Sea shelf during the Holocene.Siliciclastic mud with small amounts of sand and gravel from nearby coastal hinterland is the principal sediment type,whereas sediments deposited near the shelf edge and the (I)stanbul Strait and off the Duru Lake (a paleo-river mouth)constitued large quantities of sand and gravel of both biogenic and terrigenic origin.Variable amounts of aragonite,1 nm-micas,quartz,feldspars,calcite and dolomite constitute the dominant non-clay minerals in bulk sediments.The clay mineral assemblage in the < 2 μm fraction is made up of smectite,illite,kaolinite and chlorite.Aragonite and calcite are mainly derived from benthic accumulations,whereas feldspars (mainly plagioclase) and smectite reflect magmaticvolcanic provenance and the distribution of 1 nm-micas and chlorite correlate with nearby metamorphic sources onland.Nevertheless,grain size and mineral distribution generally indicate a combination of effects of wind and wave climate,longshore and offshore cyclonic currents,changing sea-level stands and nearby source rock and morphological conditions.It is also suggested that at least part of clay minerals could be derived from the northwesterly Danube River input.

  5. The perfect ash-storm: large-scale Pyroclastic Density Current experiments reveal highly mobile, self-fluidising and air-cushioned flow transport regime

    Science.gov (United States)

    Lube, G.; Cronin, S. J.; Breard, E.; Valentine, G.; Bursik, M. I.; Hort, M. K.; Freundt, A.

    2013-12-01

    We report on the first systematic series of large-scale Pyroclastic Density Current (PDC) experiments using the New Zealand PDC Generator, a novel international research facility in Physical Volcanology recently commissioned at Massey University. Repeatable highly energetic and hot PDCs are synthesized by the controlled ';eruption column-collapse' of up to 3500 kg of homogenously aerated Taupo ignimbrite material from a 15 m-elevated hopper onto an instrumented inclined flume. At discharge rates between 250-1300 kg/s and low- to moderate gas injection rates (yielding initial solids concentration of 15-70 vol%) channelized gas-particle mixture flows life-scaled to dense PDCs can be generated. The flow fronts of the currents reach velocities of up to 9.5 m/s over their first 12 m of travel and rapidly develop strong vertical density stratification. The PDCs typically form a highly mobile, surge that also laterally escapes the flume boundaries. Depending on the PDC starting conditions underflows with 1-45 vol% solids concentration are formed, while the upper surge contains <<1 vol.% solids. A characteristic feature of the underflow is the occurrence of 'ignitive' front breakouts, producing jetted lobes that accelerate outward from the flow front, initially forming a lobe-cleft structure, followed by segregation downslope into multiple flow pulses. Depending on initial solids concentration and discharge rate, stratified, dune-bedded and inversely graded bedforms are created whose thicknesses are remarkably uniform along the medial to distal runout path characterising highly mobile flow runout. Along with high-speed video footage we present time-series data of basal arrays of load- and gas-pore pressure transducers to characterise the mobile dense underflows. Data shows that the PDCs are comprised of a turbulent coarse-grained and air-ingesting front with particle-solids concentrations of 1-5 vol%. The front shows a brief phase of negative pore pressure due to the

  6. The Two Regimes of Postwar Shipping

    DEFF Research Database (Denmark)

    Iversen, Martin Jes; Tenold, Stig

    2014-01-01

    The aim of this article is to illustrate the most important changes in the regulatory framework of the shipping sector from the 1960s to 2010, and to analyse the basis for, and effects of, these changes. In order to explain how the transformation has occurred, we use two traditional maritime...... nations—Denmark and Norway—as case studies. First, we introduce the two regimes of Danish and Norwegian shipping: ‘the national regime’ from the early 1960s to the mid-1970s; and ‘the competitive regime’, which was fully established by the middle of the 1990s and still persists. Then, we briefly sketch...... the bargaining that accompanied the shift from the national regime to the competitive regime. Specifically, we show that the new regime primarily accommodated the interests of private actors such as shipping companies, rather than the interests of the authorities and the trade unions....

  7. Framing of regimes and transition strategies

    DEFF Research Database (Denmark)

    Jensen, Jens Stissing

    2012-01-01

    This article suggests that transition strategies are always formulated in the context of specific representations of the regime and the challenges it faces. It is argued that the framing of a regime affects the envisioning of transition strategies. An analysis of the current development agenda...

  8. The Water Abstraction License Regime in Italy: A Case for Reform?

    Directory of Open Access Journals (Sweden)

    Silvia Santato

    2016-03-01

    Full Text Available The current Water Abstraction License (WAL regime in Italy is no longer flexible enough to cope with the challenges posed by human-induced climate and global environmental changes. The cornerstones of the current regime were laid down in the 1930s and have remained essentially unchanged ever since. The sole noteworthy reform of the Italian WAL regime was the decentralization of the regulatory competences from the state to the regional authorities in the late 1990s. In this paper, we review the WAL regimes across the administrative regions comprising the Po River Basin District (PRBD, the largest and economically most important in Italy. PRBD’s WAL regime includes a rigid and scattered WAL normative that hinders the performance of bottom-up conflict resolution mechanisms at a basin scale; a water pricing scheme that does not reflect the cost of water conveyance and use, and does not encourage efficient water allocation; and the lack of a central WAL register, which delays and in some cases impedes an environmental impact assessment for issuing new licenses or renewing existing ones, and does not allow prioritizing applications according to their full economic value. We argue these deficiencies may compromise both the integrity of riverine and water dependent ecosystems and the economic uses of water. This paper offers insights that can inform reform of water allocations in the PRBD and elsewhere in Italy and in Europe.

  9. Current insights into the molecular systems pharmacology of lncRNA-miRNA regulatory interactions and implications in cancer translational medicine

    Directory of Open Access Journals (Sweden)

    Sujit Nair

    2016-04-01

    Full Text Available In recent times, the role(s of microRNAs (miRNAs and long noncoding RNAs (lncRNAs in the pathogenesis of various cancers has received great attention. Indeed, there is also a growing recognition of regulatory RNA cross-talk, i.e., lncRNA-miRNA interactions, that may modulate various events in carcinogenesis and progression to metastasis. This review summarizes current evidence in the literature of lncRNA-miRNA interactions in various cancers such as breast, liver, stomach, lung, prostate, bladder, colorectal, blood, brain, skin, kidney, cervical, laryngeal, gall bladder, and bone. Further, the potential prognostic and theragnostic clinical applications of lncRNA-miRNA interactions in cancer are discussed along with an overview of noncoding RNA (ncRNA-based studies that were presented at the American Society of Clinical Oncology (ASCO 2015. Interestingly, the last decade has seen tremendous innovation, as well as increase in complexity, of the cancer biological network(s from mRNA- to miRNA- and lncRNA-based networks. Thus, biological networks devoted to understanding regulatory interactions between these ncRNAs would be the next frontier in better elucidating the contributions of lncRNA-miRNA interactions in cancer. Herein, a cancer biological network of lncRNA-miRNA interactions is presented wherein “edges” connect interacting lncRNA-miRNA pairs, with each ncRNA serving as a discrete “node” of the network. In conclusion, the untapped potential of lncRNA-miRNA interactions in terms of its diagnostic, prognostic and therapeutic potential as targets for clinically actionable intervention as well as biomarker validation in discovery pipelines remains to be explored. Future research will likely harness this potential so as to take us closer to the goal of “precision” and “personalized medicine” which is tailor-made to the unique needs of each cancer patient, and is clearly the way forward going into the future.

  10. Recent changes (1973-2014 versus 1903-1972) in the flow regime of the Lower Paraná River and current fluvial pollution warnings in its Delta Biosphere Reserve.

    Science.gov (United States)

    Puig, Alba; Olguín Salinas, Héctor F; Borús, Juan A

    2016-06-01

    Alterations in flow regimes of large rivers may originate or increase risks to ecosystems and humans. The Paraná River basin (South America) undergoes human pressures (e.g., heavy damming in the upper basin, deforestation, and mixed pollution) that may affect the water quantity and quality of its terminal Delta (Argentina). In this study, after applying univariate and multivariate change-point detection and trend analyses to the daily data series of flows incoming to the Delta (Paraná-Santa Fe section), flow characteristics were compared by Indicators of Hydrologic Alteration (IHA) and Environmental Flow Components (EFC). Some flood characteristics were also compared from hydrometric levels in the middle Delta (San Pedro station). Chemical and microbiological water variables in the main rivers of the "Paraná Delta" Biosphere Reserve were examined during two extreme hydrologic years (October 2008 to July 2010) to detect potential risk factors in association with hydrologic conditions. In the Lower Paraná River, a historical period (1903-1972) and two more altered periods (1973-1999 wet period and 2000-2014 dry period) were identified. Flow duration curves evidenced different changes in both altered periods, reflecting the joint effect of climatic variability and human influence. The most evident alterations in the flow regime were the lack of record of the extreme-low-flow component, the attenuation of monthly flow seasonality, and the increase in the number of reversals (dry period) and in the variability of maximum and minimum flow dates. These alterations are consistent with the monthly and daily flow regulation by upstream dams evidenced by available data from the current dry period. In the middle Delta, the marked monthly seasonality in flood days decreased only in the wet period. The proportion between the number of flood days exceeding the evacuation level and that of those exceeding the warning level doubled in the wet period but decreased only

  11. Recent changes (1973-2014 versus 1903-1972) in the flow regime of the Lower Paraná River and current fluvial pollution warnings in its Delta Biosphere Reserve

    Science.gov (United States)

    Puig, Alba; Olguín Salinas, Héctor F.; Borús, Juan A.

    2016-06-01

    Alterations in flow regimes of large rivers may originate or increase risks to ecosystems and humans. The Paraná River basin (South America) undergoes human pressures (e.g., heavy damming in the upper basin, deforestation, and mixed pollution) that may affect the water quantity and quality of its terminal Delta (Argentina). In this study, after applying univariate and multivariate change-point detection and trend analyses to the daily data series of flows incoming to the Delta (Paraná-Santa Fe section), flow characteristics were compared by Indicators of Hydrologic Alteration (IHA) and Environmental Flow Components (EFC). Some flood characteristics were also compared from hydrometric levels in the middle Delta (San Pedro station). Chemical and microbiological water variables in the main rivers of the "Paraná Delta" Biosphere Reserve were examined during two extreme hydrologic years (October 2008 to July 2010) to detect potential risk factors in association with hydrologic conditions. In the Lower Paraná River, a historical period (1903-1972) and two more altered periods (1973-1999 wet period and 2000-2014 dry period) were identified. Flow duration curves evidenced different changes in both altered periods, reflecting the joint effect of climatic variability and human influence. The most evident alterations in the flow regime were the lack of record of the extreme-low-flow component, the attenuation of monthly flow seasonality, and the increase in the number of reversals (dry period) and in the variability of maximum and minimum flow dates. These alterations are consistent with the monthly and daily flow regulation by upstream dams evidenced by available data from the current dry period. In the middle Delta, the marked monthly seasonality in flood days decreased only in the wet period. The proportion between the number of flood days exceeding the evacuation level and that of those exceeding the warning level doubled in the wet period but decreased only slightly

  12. Measuring autocratic regime stability

    Directory of Open Access Journals (Sweden)

    Joseph Wright

    2016-01-01

    Full Text Available Researchers measure regime stability in autocratic contexts using a variety of data sources that capture distinct concepts. Often this research uses concepts developed for the study of democratic politics, such as leadership change or institutionalized authority, to construct measures of regime breakdown in non-democratic contexts. This article assesses whether the measure a researcher chooses influences the results they obtain by examining data on executive leadership, political authority, and autocratic regimes. We illustrate the conceptual differences between these variables by extending recent studies in the literature on the political consequences of non-tax revenue and unearned foreign income.

  13. Exchange rate regime choice

    Directory of Open Access Journals (Sweden)

    Beker Emilija

    2006-01-01

    Full Text Available The choice of an adequate exchange rate regime proves to be a highly sensitive field within which the economic authorities present and confirm themselves. The advantages and disadvantages of fixed and flexible exchange rate regimes, which have been quite relativized from the conventional point of view, together with simultaneous, but not synchronized effects of structural and external factors, remain permanently questioned throughout a complex process of exchange rate regime decision making. The paper reflects the attempt of critical identification of the key exchange rate performances with emphasis on continuous non-uniformity and (uncertainty of shelf life of a relevant choice.

  14. NRC regulatory initiatives

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, T.C. [Nuclear Regulatory Commission (United States)

    1989-11-01

    The US Nuclear Regulatory Commission (NRC) is addressing several low-level waste disposal issues that will be important to waste generators and to States and Compacts developing new disposal capacity. These issues include Greater-Than-Class C (GTCC) waste, mixed waste, below regulatory concern (BRC) waste, and the low-level waste data base. This paper discusses these issues and their current status.

  15. Regimes, Non-State Actors and the State System: A 'Structurational' Regime Model

    NARCIS (Netherlands)

    Arts, B.J.M.

    2000-01-01

    Regime analysis has become a popular approach in International Relations theory and in international policy studies. However, current regime models exhibit some shortcomings with regard to (1) addressing non-state actors, and in particular nongovernmental organizations (NGOs), (2) the balancing of

  16. Regimes, Non-State Actors and the State System: A 'Structurational' Regime Model

    NARCIS (Netherlands)

    Arts, B.J.M.

    2000-01-01

    Regime analysis has become a popular approach in International Relations theory and in international policy studies. However, current regime models exhibit some shortcomings with regard to (1) addressing non-state actors, and in particular nongovernmental organizations (NGOs), (2) the balancing of a

  17. The current status of the debate on socio-economic regulatory assessments: positions and policies in Canada, the USA, the EU and developing countries

    NARCIS (Netherlands)

    Falck-Zepeda, J.; Wesseler, J.H.H.; Smyth, S.

    2013-01-01

    Article 26.1 of the Cartagena Protocol on Biosafety has the option of considering socio-economic issues in biosafety regulatory approval processes related to genetically engineered organisms. National laws and regulations in some countries have already defined positions and may have enacted policies

  18. International Experiences with Different Monetary Policy Regimes

    OpenAIRE

    Mishkin, Frederic S.

    1999-01-01

    In recent years a growing consensus has emerged for price stability as the overriding, long-run goal of monetary policy. However, despite this consensus, the following question still remains: how should monetary policy be conducted to achieve the price stability goal? This paper examines the experience with different monetary policy regimes currently in use in a number of countries to shed light on this question. A central feature of all of the monetary regimes discussed here is the ise of a ...

  19. Detecting spatial regimes in ecosystems

    Science.gov (United States)

    Sundstrom, Shana M.; Eason, Tarsha; Nelson, R. John; Angeler, David G.; Barichievy, Chris; Garmestani, Ahjond S.; Graham, Nicholas A.J.; Granholm, Dean; Gunderson, Lance; Knutson, Melinda; Nash, Kirsty L.; Spanbauer, Trisha; Stow, Craig A.; Allen, Craig R.

    2017-01-01

    Research on early warning indicators has generally focused on assessing temporal transitions with limited application of these methods to detecting spatial regimes. Traditional spatial boundary detection procedures that result in ecoregion maps are typically based on ecological potential (i.e. potential vegetation), and often fail to account for ongoing changes due to stressors such as land use change and climate change and their effects on plant and animal communities. We use Fisher information, an information theory-based method, on both terrestrial and aquatic animal data (U.S. Breeding Bird Survey and marine zooplankton) to identify ecological boundaries, and compare our results to traditional early warning indicators, conventional ecoregion maps and multivariate analyses such as nMDS and cluster analysis. We successfully detected spatial regimes and transitions in both terrestrial and aquatic systems using Fisher information. Furthermore, Fisher information provided explicit spatial information about community change that is absent from other multivariate approaches. Our results suggest that defining spatial regimes based on animal communities may better reflect ecological reality than do traditional ecoregion maps, especially in our current era of rapid and unpredictable ecological change.

  20. Regimes of justification

    NARCIS (Netherlands)

    Arts, Irma; Buijs, A.E.; Verschoor, G.M.

    2017-01-01

    Legitimacy of environmental management and policies is an important topic in environmental research. Based on the notion of ‘regimes of justification’, we aim to analyse the dynamics in argumentations used to legitimize and de-legitimize Dutch nature conservation practices. Contrary to prior

  1. Current Scientific and Regulatory Approaches for Development of Orally Inhaled and Nasal Drug Products: Overview of the IPAC-RS/University of Florida Orlando Inhalation Conference.

    Science.gov (United States)

    Hochhaus, Guenther; Davis-Cutting, Craig; Oliver, Martin; Lee, Sau L; Lyapustina, Svetlana

    2015-09-01

    This article summarizes discussions at the March 2014 conference organized by the University of Florida (UF) and International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS), entitled "Orlando Inhalation Conference: Approaches in International Regulation." The special focus of the conference was on global scientific and regulatory issues associated with the testing and demonstration of equivalence for the registration of orally inhaled drug products (OIDPs) in the United States, Europe, Brazil, China, and India. The scope included all types of OIDPs throughout their lifecycle, e.g., innovator/brand-name products, generics, modifications due to lifecycle management, device changes, etc. Details were presented for the U.S. "weight of evidence approach" for registration of generic products (which includes demonstration of in vitro and in vivo equivalence, as well as quantitative and qualitative sameness, and device similarity). The European "stepwise" approach was elucidated, and the thinking of regulatory agencies in the major emerging markets was clarified. The conference also highlighted a number of areas that would benefit from further research and discussion, especially around patient/device interface and human factor studies, statistical methods and criteria for demonstrating equivalence, the relative roles of in vivo and in vitro tests, and appropriate designs and metrics for in vivo studies of inhaled drugs.

  2. Biosafety regulatory regimes in East and Central Africa

    African Journals Online (AJOL)

    IDDA

    protocol deals primarily with the agricultural definition, but many advocacy groups .... The World Trade Organization (WTO; http://www.wto.org). Agreements dealing ...... political climate in the region where governments are discussing political ...

  3. Zooming in on regulatory intermediaries: The impact of non-state regulators on sustainable construction practice

    NARCIS (Netherlands)

    van der Heijden, J.

    2014-01-01

    Levi-Faur and Starobin (2013) have recently drawn our attention to the important role of regulatory intermediates in contemporary regulatory regimes. Among others they argue that regulatory intermediaries come in a wide variety of appearances, and that these can influence the outcomes of regulatory

  4. The Influence of Cigarette Designs and Smoking Regimes on Vapour Phase Yields

    Directory of Open Access Journals (Sweden)

    Purkis W

    2014-12-01

    reflecting the significant reductions in VP yields, provided to the smoker by ventilation, are misleading and their results will not correlate with relevant biomarker data. When proposing a different smoking regime, it is essential to understand the generation and transfer of smoke within cigarettes and factors involved in the subsequent data interpretation as described in this work. For regulatory evaluation purposes, cigarette characterisation using a regime that removes ventilation, one of the main design tools, is more misleading than the current ISO regime or one with partial vent blocking.

  5. Regimes Of Helium Burning

    CERN Document Server

    Timmes, F X

    2000-01-01

    The burning regimes encountered by laminar deflagrations and ZND detonations propagating through helium-rich compositions in the presence of buoyancy-driven turbulence are analyzed. Particular attention is given to models of X-ray bursts which start with a thermonuclear runaway on the surface of a neutron star, and the thin shell helium instability of intermediate-mass stars. In the X-ray burst case, turbulent deflagrations propagating in the lateral or radial directions encounter a transition from the distributed regime to the flamlet regime at a density of 10^8 g cm^{-3}. In the radial direction, the purely laminar deflagration width is larger than the pressure scale height for densities smaller than 10^6 g cm^{-3}. Self-sustained laminar deflagrations travelling in the radial direction cannot exist below this density. Similarily, the planar ZND detonation width becomes larger than the pressure scale height at 10^7 g cm^{-3}, suggesting that a steady-state, self-sustained detonations cannot come into exista...

  6. Regulatory Anatomy

    DEFF Research Database (Denmark)

    Hoeyer, Klaus

    2015-01-01

    This article proposes the term “safety logics” to understand attempts within the European Union (EU) to harmonize member state legislation to ensure a safe and stable supply of human biological material for transplants and transfusions. With safety logics, I refer to assemblages of discourses, le...... they arise. In short, I expose the regulatory anatomy of the policy landscape....

  7. East Asian welfare regime

    DEFF Research Database (Denmark)

    Abrahamson, Peter

    2017-01-01

    . Political science studies tend to conclude that the region has left the old legacies behind and are now welfare states comparable to European states including them either in the conservative type (e.g. Japan), the liberal type (e.g. Korea) or even as a tendency in the Nordic type (e.g. China), while studies......The paper asks if East Asian welfare regimes are still productivist and Confucian? And, have they developed public care policies? The literature is split on the first question but (mostly) confirmative on the second. Care has to a large, but insufficient extent, been rolled out in the region...

  8. Adaptation or innovation? The effectiveness of global environmental regimes

    OpenAIRE

    2009-01-01

    The growing importance of the discourse on climate change raises some interesting questions regarding the creation and evaluation of international regimes. When is a regime effective? Through analyzing two competing approaches to evaluating regimes, the instrumentalists and critical theorists, this project shows the deficiencies in the current discourse. Instrumentalists focus on observable means-ends standards of efficiency, while critical theorists ask fundamental questions regarding inters...

  9. Supercurrent in the quantum Hall regime

    Science.gov (United States)

    Amet, F.; Ke, C. T.; Borzenets, I. V.; Wang, J.; Watanabe, K.; Taniguchi, T.; Deacon, R. S.; Yamamoto, M.; Bomze, Y.; Tarucha, S.; Finkelstein, G.

    2016-05-01

    A promising route for creating topological states and excitations is to combine superconductivity and the quantum Hall (QH) effect. Despite this potential, signatures of superconductivity in the QH regime remain scarce, and a superconducting current through a QH weak link has been challenging to observe. We demonstrate the existence of a distinct supercurrent mechanism in encapsulated graphene samples contacted by superconducting electrodes, in magnetic fields as high as 2 tesla. The observation of a supercurrent in the QH regime marks an important step in the quest for exotic topological excitations, such as Majorana fermions and parafermions, which may find applications in fault-tolerant quantum computing.

  10. Considerations regarding the collection of pesticide use information for regulatory purposes

    NARCIS (Netherlands)

    Marquart, J.

    2001-01-01

    Proper use information is necessary to do exposure modelling in the scope of regulatory risk assessments. The legal regime under which the regulatory risk assessment is done influences the need for use information. Different legal regimes lead to more or less possibilities for authorities to define

  11. Supply regimes in fisheries

    DEFF Research Database (Denmark)

    Nielsen, Max

    2006-01-01

    Supply in fisheries is traditionally known for its backward bending nature, owing to externalities in production. Such a supply regime, however, exist only for pure open access fisheries. Since most fisheries worldwide are neither pure open access, nor optimally managed, rather between the extremes......-economic supply model with mesh sizes is developed. It is found that in the presence of realistic management schemes, the supply curves are close to vertical in the relevant range. Also, the supply curve under open access with mesh size limitations is almost vertical in the relevant range, owing to constant...... recruitment. The implications are that the effects on supply following from e.g. trade liberalisation and reductions of subsidies are small in several and probably most fisheries worldwide. Keywords: backward-bending supply, regulated open access, regulated restricted access, mesh size regulation, Beverton...

  12. Análise comparativa do desenho normativo de instituições reguladoras do presente e do passado Comparative analysis of the normative design of former and current regulatory institutions

    Directory of Open Access Journals (Sweden)

    Antonio Gelis Filho

    2006-08-01

    Full Text Available Este artigo desenvolve um modelo matricial para avaliação do desenho normativo de instituições reguladoras do presente e do passado (autarquias econômicas da república "populista". Desenho normativo é definido como o conjunto de possibilidades de estruturação e de atuação de uma instituição que é delimitado pelas normas jurídicas que a criaram. O modelo é estruturado a partir de dois parâmetros principais: independência em relação ao poder central e transparência em relação à sociedade. Foram testadas cinco hipóteses, concluindo-se que as instituições reguladoras do presente apresentam desenhos normativos heterogêneos e que se distinguem de instituições do passado tanto por maior independência quanto por maior transparência, sendo a diferença mais acentuada em relação ao segundo parâmetro.This article develops a matrix model to assess the normative design of past and current regulatory institutions (economic autarchies of the 'populist' republic. Normative design is defined as a set of possibilities for an institution's structure and actions which is limited by the legal norms that created it. The model is structured based on two main parameters: independence in relation to the central power and transparency in relation to society. Five hypothesis were tested, and the conclusion was that current regulatory institutions have heterogeneous designs and they differ from the former ones for being both more independent and more transparent, and the largest difference is in the second parameter.

  13. Resilience of river flow regimes.

    Science.gov (United States)

    Botter, Gianluca; Basso, Stefano; Rodriguez-Iturbe, Ignacio; Rinaldo, Andrea

    2013-08-06

    Landscape and climate alterations foreshadow global-scale shifts of river flow regimes. However, a theory that identifies the range of foreseen impacts on streamflows resulting from inhomogeneous forcings and sensitivity gradients across diverse regimes is lacking. Here, we derive a measurable index embedding climate and landscape attributes (the ratio of the mean interarrival of streamflow-producing rainfall events and the mean catchment response time) that discriminates erratic regimes with enhanced intraseasonal streamflow variability from persistent regimes endowed with regular flow patterns. Theoretical and empirical data show that erratic hydrological regimes typical of rivers with low mean discharges are resilient in that they hold a reduced sensitivity to climate fluctuations. The distinction between erratic and persistent regimes provides a robust framework for characterizing the hydrology of freshwater ecosystems and improving water management strategies in times of global change.

  14. Healthcare regulatory concepts in Brazil.

    Science.gov (United States)

    Oliveira, Robson Rocha de; Elias, Paulo Eduardo Mangeon

    2012-06-01

    The healthcare regulatory concepts used in Brazilian scientific publications on healthcare management were reviewed. A typo-logical classification for regulatory concepts was developed from the most current ideas in five disciplines: life sciences, law, economics, sociology and political science. Four ideas stood out: control, balance, adaptation and direction, with greatest emphasis on the technical nature of regulation. The political nature of regulation was secondary. It was considered that dis-cussion of healthcare regulatory concepts was connected with comprehension of the role that the state plays in this sector. De-finition of the forms of state intervention is the key convergence point between the different ways of conceptualizing healthcare regulation.

  15. Unitary Housing Regimes in Transition

    DEFF Research Database (Denmark)

    Bengtsson, Bo; Jensen, Lotte

    2013-01-01

    to the Danish and Swedish housing regimes are analysed and the responses and outcomes in terms of policy change and/or institutional continuity (path dependence) are compared. Overall, the more decentralized Danish housing regime seems to have resisted pressures for change and retrenchment better so far than...

  16. Regime shifts in resource management

    NARCIS (Netherlands)

    de Zeeuw, A.J.

    2014-01-01

    Resource management has to take account of the possibility of tipping points and regime shifts in ecological systems that provide the resources. This article focuses on the typical model of regime shifts in the ecological literature and analyzes optimal management and common-property issues when tra

  17. Examination Regimes and Student Achievement

    Science.gov (United States)

    Cosentino de Cohen, Clemencia

    2010-01-01

    Examination regimes at the end of secondary school vary greatly intra- and cross-nationally, and in recent years have undergone important reforms often geared towards increasing student achievement. This research presents a comparative analysis of the relationship between examination regimes and student achievement in the OECD. Using a micro…

  18. 'Regime shopping' across (blurring) boundaries

    NARCIS (Netherlands)

    Houwerzijl, M.S.; Evju, Stein

    2014-01-01

    This book chapter identifies and explores the (blurring) boundaries between the legal regimes for labour mobility across the EU. In the context of - what is sometimes called - 'regime shopping' a close look is taken into the law on freedom of movement within the EU. Several categories of transnation

  19. 'Regime shopping' across (blurring) boundaries

    NARCIS (Netherlands)

    Houwerzijl, M.S.; Evju, Stein

    2014-01-01

    This book chapter identifies and explores the (blurring) boundaries between the legal regimes for labour mobility across the EU. In the context of - what is sometimes called - 'regime shopping' a close look is taken into the law on freedom of movement within the EU. Several categories of

  20. A combined park management framework based on regulatory and behavioral strategies: use of visitors' knowledge to assess effectiveness.

    Science.gov (United States)

    Papageorgiou, K

    2001-07-01

    In light of the increasing mandate for greater efficiency in conservation of natural reserves such as national parks, the present study suggests educational approaches as a tool to achieve conservation purposes. Currently, the management of human-wildlife interactions is dominated by regulatory strategies, but considerable potential exists for environmental education to enhance knowledge in the short run and to prompt attitude change in the long run. A framework for conservation based on both traditional regulatory- and behavior-oriented strategies was proposed whereby the level of knowledge that park visitors have acquired comprises an obvious outcome and establishes a basis upon which the effectiveness of regulatory- and behavior-based regimes could be assessed. The perceptions regarding park-related issues of two distinct visitor groups (locals and nonlocals) are summarized from a survey undertaken in Vikos-Aoos national park. The findings suggest a superficial knowledge for certain concepts but little profound understanding of the content of such concepts, indicating that knowledge-raising efforts should go a long way towards establishing a positive attitude for the resource. Visitors' poor knowledge of the park's operation regulation contest the efficiency of the presently dominant regulatory management regime. While geographical distances did not appear to significantly differentiate knowledge between the two groups, wilderness experience (as certified by visits to other parks) was proved to be an impetus for generating substantial learner interest in critical park issues among nonlocal visitors. School education and media were found to be significant knowledge providers.

  1. Capacity attributes of future urban water management regimes: projections from Australian sustainability practitioners.

    Science.gov (United States)

    van de Meene, S J; Brown, R R; Farrelly, M A

    2010-01-01

    Transitioning to more sustainable urban water management is widely accepted as an essential societal objective. While there has been significant progress in developing technical solutions to the challenges faced, numerous barriers remain at the regime level, indicating that further investigation into the regime is required. This paper reports on a social research project aimed at identifying capacity attributes of a more sustainable urban water management regime. Attributes were identified for the administrative and regulatory framework, inter- and intra-organisational and individual regime spheres. Over 125 urban water practitioners specialising in sustainability in Sydney and Melbourne were interviewed to identify the attributes of a more sustainable regime. The attributes reveal that a sustainable urban water management regime emphasises learning, diverse policy tools and institutional arrangements, together with interaction among stakeholders and professional disciplines. The interaction is characterised by respect, trust and mutual understanding. The sustainable regime attributes are compared to the traditional regime and reveal that while progress has been made towards a sustainable regime, additional improvement is required. Attributes identified across multiple regime spheres indicate potential focus areas for capacity building programs or reform efforts to more effectively enable regime change towards sustainable urban water management.

  2. The Choice of Monetary Regime

    DEFF Research Database (Denmark)

    Østrup, Finn

    , a comparisonbetween monetary regimes suggests that welfare is highest under nominalincome targeting where the nominal income target is determined to bring aboutprice stability.Keywords: Monetary regimes; fiscal policy; monetary non-neutrality.JEL classicification: E42, E61, E62.......The article examines how government spending is determined in a closedeconomy where the nominal wage is pre-set through contracts and the wage settershave perfect foresight regarding subsequent policy decisions. The monetaryregime affects government spending because: (i) with a pre-set nominal wage......, agiven change in government spending has different effects on employment andinflation under different monetary regimes, and (ii) the authorities' inclinationto expand government spending is affected by the inflation rate which dependson the monetary regime. If the costs related to inflation are high...

  3. THE ETHIOPIAN ENVIRONMENTAL REGIME VERSUS ...

    African Journals Online (AJOL)

    Haramaya Law Review ... ozone layer and climate change regimes, among others, to succeed. Id. ... international act dealing with general aspects of air pollution. ..... environmental and developmental decisions that affect their interests or the.

  4. Regulatory Snapshots: integrative mining of regulatory modules from expression time series and regulatory networks.

    Directory of Open Access Journals (Sweden)

    Joana P Gonçalves

    Full Text Available Explaining regulatory mechanisms is crucial to understand complex cellular responses leading to system perturbations. Some strategies reverse engineer regulatory interactions from experimental data, while others identify functional regulatory units (modules under the assumption that biological systems yield a modular organization. Most modular studies focus on network structure and static properties, ignoring that gene regulation is largely driven by stimulus-response behavior. Expression time series are key to gain insight into dynamics, but have been insufficiently explored by current methods, which often (1 apply generic algorithms unsuited for expression analysis over time, due to inability to maintain the chronology of events or incorporate time dependency; (2 ignore local patterns, abundant in most interesting cases of transcriptional activity; (3 neglect physical binding or lack automatic association of regulators, focusing mainly on expression patterns; or (4 limit the discovery to a predefined number of modules. We propose Regulatory Snapshots, an integrative mining approach to identify regulatory modules over time by combining transcriptional control with response, while overcoming the above challenges. Temporal biclustering is first used to reveal transcriptional modules composed of genes showing coherent expression profiles over time. Personalized ranking is then applied to prioritize prominent regulators targeting the modules at each time point using a network of documented regulatory associations and the expression data. Custom graphics are finally depicted to expose the regulatory activity in a module at consecutive time points (snapshots. Regulatory Snapshots successfully unraveled modules underlying yeast response to heat shock and human epithelial-to-mesenchymal transition, based on regulations documented in the YEASTRACT and JASPAR databases, respectively, and available expression data. Regulatory players involved in

  5. Regulatory system reform of occupational health and safety in China.

    Science.gov (United States)

    Wu, Fenghong; Chi, Yan

    2015-01-01

    With the explosive economic growth and social development, China's regulatory system of occupational health and safety now faces more and more challenges. This article reviews the history of regulatory system of occupational health and safety in China, as well as the current reform of this regulatory system in the country. Comprehensive, a range of laws, regulations and standards that promulgated by Chinese government, duties and responsibilities of the regulatory departments are described. Problems of current regulatory system, the ongoing adjustments and changes for modifying and improving regulatory system are discussed. The aim of reform and the incentives to drive forward more health and safety conditions in workplaces are also outlined.

  6. O-regime dynamics and modeling in Tore Supra

    Science.gov (United States)

    Turco, F.; Giruzzi, G.; Imbeaux, F.; Udintsev, V. S.; Artaud, J. F.; Barana, O.; Dumont, R.; Mazon, D.; Ségui, J.-L.

    2009-06-01

    The regime of nonlinear temperature oscillations (O-regime), characteristic of noninductive discharges on Tore Supra [Équipe Tore Supra, Proceedings of the 12th International Conference on Plasma Physics and Controlled Nuclear Fusion Research, Nice, France, 1988 (International Atomic Energy Agency, Vienna, 1989), Vol. 1, p. 9], is investigated in its triggering and suppressing mechanism. This regime can be described by two nonlinearly coupled equations for the current density j(r ) and the electron temperature Te(r) where the equation coefficients are functions of j and Te themselves. Both the integrated modeling code CRONOS [V. Basiuk et al., Nucl. Fusion 43, 822 (2003)] and a two-patch predator-prey system with diffusion and noise have been used and results have been compared to the experimental observations of the O-regime. A database of discharges is analyzed which features monotonic, flat, and reversed safety factor (q) profiles in order to characterize the action of external actuators on the regime dynamics with the widest generality. Electron cyclotron current drive and neutral beam injections have been used in order to induce localized perturbations in the total current profile j(r ) as well as to change the plasma confinement conditions in the central region. Magnetic shear perturbations and modifications of the heat transport turn out to be the central parameters governing the dynamics of the O-regime.

  7. Detecting spatial regimes in ecosystems | Science Inventory ...

    Science.gov (United States)

    Research on early warning indicators has generally focused on assessing temporal transitions with limited application of these methods to detecting spatial regimes. Traditional spatial boundary detection procedures that result in ecoregion maps are typically based on ecological potential (i.e. potential vegetation), and often fail to account for ongoing changes due to stressors such as land use change and climate change and their effects on plant and animal communities. We use Fisher information, an information theory based method, on both terrestrial and aquatic animal data (US Breeding Bird Survey and marine zooplankton) to identify ecological boundaries, and compare our results to traditional early warning indicators, conventional ecoregion maps, and multivariate analysis such as nMDS (non-metric Multidimensional Scaling) and cluster analysis. We successfully detect spatial regimes and transitions in both terrestrial and aquatic systems using Fisher information. Furthermore, Fisher information provided explicit spatial information about community change that is absent from other multivariate approaches. Our results suggest that defining spatial regimes based on animal communities may better reflect ecological reality than do traditional ecoregion maps, especially in our current era of rapid and unpredictable ecological change. Use an information theory based method to identify ecological boundaries and compare our results to traditional early warning

  8. MULTILATERAL DIPLOMACY AND INTERNATIONAL REGIMES

    Directory of Open Access Journals (Sweden)

    BENEA Ciprian-Beniamin

    2014-12-01

    Full Text Available The history of diplomacy can by divided in three main periods: one is that of occasional diplomacy peculiar to Middle Ages, while other belong to permane diplomacy, peculiar to modern times. But this one can be divided in two parts, too: one with a bilateral character, previos to 1st World War, and one with a multilateral character, manifested especially after the end on 1st World War. This third type is the focus of present paper. And it cannot be separated from the newly international constructs: international regimes, and international organizations. International instritutions the area where international regimes are belonging to – are legal constructs which provide the formal (and legal framework for continous negotiations. They are the most visible part of the new diplomacy – the one which has a permanent character, and it has an more open face. Anyway, the most important connection has to do with the international institutions, international regimes, and multilateral international negotiations. In the era of the new diplomacy, they all have a permanent character. International institutions help international negotiations carring on; while in their turn, they provide the base for international regimes’ creation, and especially for their evolution. The international regimes’ evolution is an inseparable part of a permanent international framework. And if there is missing a permanent international framework (international organization connected to a specific regime, this regime is a difuse one, its members have only informal relations among them, while they survey each other, looking at their behavior, but they don’t have a formal relationship among them, which could help them solving their future common interests, and protect them from their common fears. International regimes are very important in the era when evrithing touches, and influences everything. In the same time, the complexity of our present world can be successfully

  9. Great Lakes' regional climate regimes

    Science.gov (United States)

    Kravtsov, Sergey; Sugiyama, Noriyuki; Roebber, Paul

    2016-04-01

    We simulate the seasonal cycle of the Great Lakes' water temperature and lake ice using an idealized coupled lake-atmosphere-ice model. Under identical seasonally varying boundary conditions, this model exhibits more than one seasonally varying equilibrium solutions, which we associate with distinct regional climate regimes. Colder/warmer regimes are characterized by abundant/scarce amounts of wintertime ice and cooler/warmer summer temperatures, respectively. These regimes are also evident in the observations of the Great Lakes' climate variability over recent few decades, and are found to be most pronounced for Lake Superior, the deepest of the Great Lakes, consistent with model predictions. Multiple climate regimes of the Great Lakes also play a crucial role in the accelerated warming of the lakes relative to the surrounding land regions in response to larger-scale global warming. We discuss the physical origin and characteristics of multiple climate regimes over the lakes, as well as their implications for a longer-term regional climate variability.

  10. Friction Regimes in the Lubricants Solid-State Regime

    NARCIS (Netherlands)

    Schipper, D.J.; Maathuis, O.; Dowson, D.; Taylor, C.M.; Childs, T.H.C.; Dalmaz, G.

    1995-01-01

    Friction measurements were performed in the lubricant's solid-state regime to study the transition from full-film lubrication, in which the separation is maintained by a solidified lubricant, to mixed lubrication. Special attention is paid to the influence of temperature (inlet viscosity) and roughn

  11. On the regimes of premixing

    Energy Technology Data Exchange (ETDEWEB)

    Angelini, S.; Theofanous, T.G.; Yuen, W.W. [California Univ., Santa Barbara, CA (United States). Center for Risk Studies and Safety

    1998-01-01

    The conditions of the MAGICO-2000 experiment are extended to more broadly investigate the regimes of premixing, and the corresponding internal structures of mixing zones. With the help of the data and numerical simulations using the computer code PM-ALPHA, we can distinguish extremes of behavior dominated by inertia and thermal effects - we name these the inertia and thermal regimes, respectively. This is an important distinction that should guide future experiments aimed at code verification in this area. Interesting intermediate behaviors are also delineated and discussed. (author)

  12. [Heath and political regimes: presidential or parliamentary government for Colombia?].

    Science.gov (United States)

    Idrovo, Alvaro J

    2007-01-01

    Changing the presidential regime for a parliamentarian one is currently be-ing discussed in Colombia. This preliminary study explores the potential effects on health of both presidential and parliamentary regimes by using world-wide data. An ecological study was undertaken using countries from which comparable information concerning life-expectancy at birth, political regime, economic development, inequality in income, social capital (as measured by general-ised trust or Corruption Perceptions Index), political rights, civil freedom and cultural diversity could be obtained. Life-expectancy at birth and macro-determinants were compared between both political regimes. The co-relationship between these macro-determinants was estimated and the relationship between political regimen and life-expectancy at birth was estimated using robust regression. Crude analysis revealed that parliamentary countries have greater life-expectancy at birth than countries having a presidential regime. Significant co-relationships between all macro-determinants were observed. No differential effects were observed between both political regimes regarding life-expectancy at birth in multiple robust regressions. There is no evidence that presidential or parliamentary regimes provide greater levels of health for the population. It is suggested that public health policies be focused on other macro-determinants having more known effects on health, such as income inequality.

  13. Regulatory Promotion of Emergent CCS Technology

    Energy Technology Data Exchange (ETDEWEB)

    Davies, Lincoln; Uchitel, Kirsten; Johnson, David

    2014-01-01

    Despite the growing inevitability of climate change and the attendant need for mitigation strategies, carbon capture and sequestration (CCS) has yet to gain much traction in the United States. Recent regulatory proposals by the U.S. Environmental Protection Agency (EPA), limited in scope to new-build power plants, represent the only significant policy initiative intended to mandate diffusion of CCS technology. Phase I of this Project assessed barriers to CCS deployment as prioritized by the CCS community. That research concluded that there were four primary barriers: (1) cost, (2) lack of a carbon price, (3) liability, and (4) lack of a comprehensive regulatory regime. Phase II of this Project, as presented in this Report, assesses potential regulatory models for CCS and examines where those models address the hurdles to diffusing CCS technology identified in Phase I. It concludes (1) that a CCS-specific but flexible standard, such as a technology performance standard or a very particular type of market-based regulation, likely will promote CCS diffusion, and (2) that these policies cannot work alone, but rather, should be combined with other measures, such as liability limits and a comprehensive CCS regulatory regime.

  14. General Considerations about Matrimonial Regime under the Provisions of the New Romanian Civil Code

    Directory of Open Access Journals (Sweden)

    Nadia Cerasela ANITEI

    2011-12-01

    Full Text Available The provisions of art. 312 of the Civil Code establish: a legal system, that is the community property regime and two types of conventional regimes: the regime of separation of goods and the regime of conventional community (the latter includes conventional derogation from community property regime.Legal matrimonial regime includes assets acquired by each spouse during marriage, except property required by law, which represents each spouse’s own assets.Community legal regime will apply in all situations in which prospective spouses opt for separation of property regime or the regime of conventional community.Separation of property regime is characterized by the fact that each of the spouses is the exclusive owner of their current assets and of those acquired alone after the dissolution of marriage, for the adoption of this regime the spouses being forced to draw up an inventory of movable property belonging to each one at the contracting of marriage.Conventional community regime is applicable when by matrimonial agreement, it derogates from the provisions on legal community regime, and the matrimonial convention concluded in this case can narrow or broaden the community of goods.

  15. Creation and evolution of North America's gas and electricity regime: A dynamic example of interdependence

    Science.gov (United States)

    Dukert, Joseph M.

    Growing interdependence of Canada, the United States, and Mexico in production, trade, and consumption of natural gas and electricity during the 1990s produced a new North American functional entity---partly governmental, partly non-governmental, and partly intergovernmental. Cooperation among three dissimilar, jealously sovereign countries has surmounted several shocks (California's flawed energy "deregulation" experiments, Enron's scandal, disagreements over the Kyoto Protocol and the Iraq invasion, soaring energy prices, and economic downturns). Explaining this as an international regime (a system of principles, norms, rules, and decision-making procedures around which actor expectations converge in a given issue area), this work explains the timing of its emergence...and how its self-adjusting nature portends increasing significance. Extensive interviews are augmented by newly obtained U.S. government documents about U.S.-Mexican gas negotiations in the late 1970s---when a regime seemed logical, but when necessary and sufficient conditions were lacking. The North American Free Trade Agreement had to be accompanied by regulatory reforms and some market effects, while the gas and electricity industries converged and electronic developments facilitated exchanges of current and future supplies of gas and/or electricity. Now, mutually beneficial pipeline and powerline connections spur expansion, while backsliding from regime acceptance becomes ever more costly---especially for some regions. This is a "virtual" regime---sensed by those involved with no formal charter beyond NAFTA's vague treatment of energy. It is "metanational"---grounded both within and beyond these nation-states. Operating in accord with varied modes of governance, but also through such modest institutions as the North American Energy Working Group and the North American Commission for Environmental Cooperation, the regime supports differing national energy policy goals for the three countries and

  16. Adelie penguin foraging location predicted by tidal regime switching.

    Directory of Open Access Journals (Sweden)

    Matthew J Oliver

    Full Text Available Penguin foraging and breeding success depend on broad-scale environmental and local-scale hydrographic features of their habitat. We investigated the effect of local tidal currents on a population of Adélie penguins on Humble Is., Antarctica. We used satellite-tagged penguins, an autonomous underwater vehicle, and historical tidal records to model of penguin foraging locations over ten seasons. The bearing of tidal currents did not oscillate daily, but rather between diurnal and semidiurnal tidal regimes. Adélie penguins foraging locations changed in response to tidal regime switching, and not to daily tidal patterns. The hydrography and foraging patterns of Adélie penguins during these switching tidal regimes suggest that they are responding to changing prey availability, as they are concentrated and dispersed in nearby Palmer Deep by variable tidal forcing on weekly timescales, providing a link between local currents and the ecology of this predator.

  17. Toxicogenomics in regulatory ecotoxicology

    Science.gov (United States)

    Ankley, Gerald T.; Daston, George P.; Degitz, Sigmund J.; Denslow, Nancy D.; Hoke, Robert A.; Kennedy, Sean W.; Miracle, Ann L.; Perkins, Edward J.; Snape, Jason; Tillitt, Donald E.; Tyler, Charles R.; Versteeg, Donald

    2006-01-01

    Recently, we have witnessed an explosion of different genomic approaches that, through a combination of advanced biological, instrumental, and bioinformatic techniques, can yield a previously unparalleled amount of data concerning the molecular and biochemical status of organisms. Fueled partially by large, well-publicized efforts such as the Human Genome Project, genomic research has become a rapidly growing topical area in multiple biological disciplines. Since 1999, when the term “toxicogenomics” was coined to describe the application of genomics to toxicology (1), a rapid increase in publications on the topic has occurred (Figure 1). The potential utility of toxicogenomics in toxicological research and regulatory activities has been the subject of scientific discussions and, as with any new technology, has evoked a wide range of opinion (2–6). VIEWPOINT © 2006 american chemical Society july 1, 2006 / EnvironmEntal SciEncE & tEchnology n 4055 The purpose of this feature article is to consider the roles of toxicogenomics in the field of regulatory ecotoxicology, explore current limitations in the science and practice of genomics, and propose possible avenues to approach and resolve some of the major challenges. A significant amount of input to our analysis came from a workshop sponsored by the Society of Environmental Toxicology and Chemistry (SETAC) in Pellston, Mich., in September 2005. A complete list of names and affiliations of the experts participating in that workshop is provided online in Table 1 of the Supporting Information for this paper.

  18. Monetary regimes in open economies

    NARCIS (Netherlands)

    Korpos, A.

    2006-01-01

    This thesis presents a two-country open economy framework for the analysis of strategic interactions among monetary authorities and wage bargaining institutions. From this perspective, the thesis investigates the economic consequences of replacing flexible and fixed exchange rate regimes with a mone

  19. IPTV Market Development and Regulatory Aspects

    DEFF Research Database (Denmark)

    Tadayoni, Reza; Sigurdsson, Halldór Matthias

    2006-01-01

    The aim of this paper is to analyse the development of IPTV technology / market and to discuss major regulatory parameters. A general overview of architectures and the technologies deployed for establishing IPTV services is given and the main stake holder identified, along with, the current service...... architecture, the available content in IPTV platforms, and the current business models. Furthermore the regulatory framework of the TV broadcast and IPTV in Europe is analysed....

  20. Regulatory considerations for biosimilars

    Directory of Open Access Journals (Sweden)

    Ranjani Nellore

    2010-01-01

    Full Text Available Currently there is considerable interest in the legislative debate around generic biological drugs or "biosimilars" in the EU and US due to the large, lucrative market that it offers to the industry. While some countries have issued a few regulatory guidelines as well as product specific requirements, there is no general consensus as to a single, simple mechanism similar to the bioequivalence determination that leads to approval of generic small molecules all over the world. The inherent complex nature of the molecules, along with complicated manufacturing and analytical techniques to characterize them make it difficult to rely on a single human pharmacokinetic study for assurance of safety and efficacy. In general, the concept of comparability has been used for evaluation of the currently approved "similar" biological where a step by step assessment on the quality, preclinical and clinical aspects is made. In India, the focus is primarily on the availability and affordability of life-saving drugs. In this context every product needs to be evaluated on its own merit irrespective of the innovator brand. The formation of the National Biotechnology Regulatory Authority may provide a step in the right direction for regulation of these complex molecules. However, in order to have an efficient machinery for initial approval and ongoing oversight with a country-specific focus, cooperation with international authorities for granting approvals and continuous risk-benefit review is essential. Several steps are still needed for India to be perceived as a country that leads the world in providing quality biological products.

  1. Nonlinear regimes of forced magnetic reconnection

    Energy Technology Data Exchange (ETDEWEB)

    Vekstein, G., E-mail: g.vekstein@manchester.ac.uk [JBCA, School of Physics and Astronomy, University of Manchester, Manchester M13 9PL (United Kingdom); STEL, Nagoya University, Nagoya, Aichi 464-8601 (Japan); Kusano, K. [STEL, Nagoya University, Nagoya, Aichi 464-8601 (Japan)

    2015-09-15

    This letter presents a self-consistent description of nonlinear forced magnetic reconnection in Taylor's model of this process. If external boundary perturbation is strong enough, nonlinearity in the current sheet evolution becomes important before resistive effects come into play. This terminates the current sheet shrinking that takes place at the linear stage and brings about its nonlinear equilibrium with a finite thickness. Then, in theory, this equilibrium is destroyed by a finite plasma resistivity during the skin-time, and further reconnection proceeds in the Rutherford regime. However, realization of such a scenario is unlikely because of the plasmoid instability, which is fast enough to develop before the transition to the Rutherford phase occurs. The suggested analytical theory is entirely different from all previous studies and provides proper interpretation of the presently available numerical simulations of nonlinear forced magnetic reconnection.

  2. Exchange rate regimes and monetary arrangements

    Directory of Open Access Journals (Sweden)

    Ivan Ribnikar

    2005-06-01

    Full Text Available There is a close relationship between a country’s exchange rate regime and monetary arrangement and if we are to examine monetary arrangements then exchange rate regimes must first be analysed. Within the conventional and most widely used classification of exchange rate regimes into rigid and flexible or into polar regimes (hard peg and float on one side, and intermediate regimes on the other there, is a much greater variety among intermediate regimes. A more precise and, as will be seen, more useful classification of exchange rate regimes is the first topic of the paper. The second topic is how exchange rate regimes influence or determine monetary arrangements and monetary policy or monetary policy regimes: monetary autonomy versus monetary nonautonomy and discretion in monetary policy versus commitment in monetary policy. Both topics are important for countries on their path to the EU and the euro area

  3. The Concept of Truth Regime

    Directory of Open Access Journals (Sweden)

    Lorna Weir

    2008-07-01

    Full Text Available “Truth regime” is a much used but little theorized concept, with the Foucauldian literature presupposing that truth in modernity is uniformly scientific/quasi-scientific and enhances power. I argue that the forms of truth characteristic of our present are wider than Foucault recognized, their relations to power more various, and their historicity more complex. The truth regime of advanced modernity is characterized by multiple, irreducible truth formulae that co-exist and sometimes vie for dominance. A truth formula stabilizes a network of elements: a relation between representation and presentation (words and things, truth and non-truth, and the place of the subject in discourse. Our contemporary truth regime comprises radically heterogeneous truthful knowledges – science, governance, religion/politics, and common culture – that have distinct histories and relations to power.

  4. Transient regimes of the three-phase power transformers

    Directory of Open Access Journals (Sweden)

    Olivian Chiver

    2015-12-01

    Full Text Available The transient regimes of a three-phase power transformer will be studied in this paper. The transient currents in the windings will be determined both analytically and by finite elements method (FEM. The no load and short circuit regimes will be considered. The current dependence of the instantaneous phase voltage and of the initial current value will be highlighted, by FEM. In order to determine analytically the transient currents, for inductances the analytical and FEM values will be used. The inductances are determined with FEM through the simulation of experimental tests. With FEM, the transient currents will be determined using transient analysis. Finally, the FEM and analytical results will be compared and discussed.

  5. The Dutch drug policy from a regulatory perspective

    NARCIS (Netherlands)

    Spapens, A.C.M.; Müller, T.; Van de Bunt, H.G.

    2015-01-01

    Starting in the 1970s, the Netherlands developed a regulatory regime for narcotic drugs by distinguishing between hashish and marihuana (“soft drugs”) and other drugs (“hard drugs”). The authorities decided to cease prosecuting the possession of consumer quantities of the former type and to allow

  6. The Dutch drug policy from a regulatory perspective

    NARCIS (Netherlands)

    Spapens, A.C.M.; Müller, T.; Van de Bunt, H.G.

    2015-01-01

    Starting in the 1970s, the Netherlands developed a regulatory regime for narcotic drugs by distinguishing between hashish and marihuana (“soft drugs”) and other drugs (“hard drugs”). The authorities decided to cease prosecuting the possession of consumer quantities of the former type and to allow th

  7. The Dutch drug policy from a regulatory perspective

    NARCIS (Netherlands)

    Spapens, A.C.M.; Müller, T.; Van de Bunt, H.G.

    2015-01-01

    Starting in the 1970s, the Netherlands developed a regulatory regime for narcotic drugs by distinguishing between hashish and marihuana (“soft drugs”) and other drugs (“hard drugs”). The authorities decided to cease prosecuting the possession of consumer quantities of the former type and to allow th

  8. Burning plasma regime for Fussion-Fission Research Facility

    Science.gov (United States)

    Zakharov, Leonid E.

    2010-11-01

    The basic aspects of burning plasma regimes of Fusion-Fission Research Facility (FFRF, R/a=4/1 m/m, Ipl=5 MA, Btor=4-6 T, P^DT=50-100 MW, P^fission=80-4000 MW, 1 m thick blanket), which is suggested as the next step device for Chinese fusion program, are presented. The mission of FFRF is to advance magnetic fusion to the level of a stationary neutron source and to create a technical, scientific, and technology basis for the utilization of high-energy fusion neutrons for the needs of nuclear energy and technology. FFRF will rely as much as possible on ITER design. Thus, the magnetic system, especially TFC, will take advantage of ITER experience. TFC will use the same superconductor as ITER. The plasma regimes will represent an extension of the stationary plasma regimes on HT-7 and EAST tokamaks at ASIPP. Both inductive discharges and stationary non-inductive Lower Hybrid Current Drive (LHCD) will be possible. FFRF strongly relies on new, Lithium Wall Fusion (LiWF) plasma regimes, the development of which will be done on NSTX, HT-7, EAST in parallel with the design work. This regime will eliminate a number of uncertainties, still remaining unresolved in the ITER project. Well controlled, hours long inductive current drive operation at P^DT=50-100 MW is predicted.

  9. The essence of fire regime-condition class assessment

    Science.gov (United States)

    McKinley-Ben Miller

    2008-01-01

    The interagency-Fire Regime / Condition Class - assessment process (FRCC) represents a contemporary and effective means of estimating the relative degree of difference or "departure" a subject landscape condition is currently in, as compared to the historic or reference ecological conditions. This process generally applied to fire adapted systems is science-...

  10. Sputtering of Ge(001): transition between dynamic scaling regimes

    DEFF Research Database (Denmark)

    Smilgies, D.-M.; Eng, P.J.; Landemark, E.;

    1997-01-01

    We have studied the dynamic behavior of the Ge(001) surface during sputtering in situ and in real time using synchrotron X-ray diffraction. We find two dynamic regimes as a function of surface temperature and sputter current which are separated by a sharp transition. The boundary between these two...

  11. The january effect across volatility regimes

    OpenAIRE

    Agnani, Betty; Aray, Henry

    2007-01-01

    Using a Markov regime switching model, this article presents evidence on the well-known January effect on stock returns. The specification allows a distinction to be drawn between two regimes, one with high volatility and other with low volatility. We obtain a time-varying January effect that is, in general, positive and significant in both volatility regimes. However, this effect is larger in the high volatility regime. In sharp contrast with most previous literature we find two major result...

  12. Genomics in the land of regulatory science.

    Science.gov (United States)

    Tong, Weida; Ostroff, Stephen; Blais, Burton; Silva, Primal; Dubuc, Martine; Healy, Marion; Slikker, William

    2015-06-01

    Genomics science has played a major role in the generation of new knowledge in the basic research arena, and currently question arises as to its potential to support regulatory processes. However, the integration of genomics in the regulatory decision-making process requires rigorous assessment and would benefit from consensus amongst international partners and research communities. To that end, the Global Coalition for Regulatory Science Research (GCRSR) hosted the fourth Global Summit on Regulatory Science (GSRS2014) to discuss the role of genomics in regulatory decision making, with a specific emphasis on applications in food safety and medical product development. Challenges and issues were discussed in the context of developing an international consensus for objective criteria in the analysis, interpretation and reporting of genomics data with an emphasis on transparency, traceability and "fitness for purpose" for the intended application. It was recognized that there is a need for a global path in the establishment of a regulatory bioinformatics framework for the development of transparent, reliable, reproducible and auditable processes in the management of food and medical product safety risks. It was also recognized that training is an important mechanism in achieving internationally consistent outcomes. GSRS2014 provided an effective venue for regulators andresearchers to meet, discuss common issues, and develop collaborations to address the challenges posed by the application of genomics to regulatory science, with the ultimate goal of wisely integrating novel technical innovations into regulatory decision-making.

  13. Implementation Regimes and Street-Level Bureaucrats

    DEFF Research Database (Denmark)

    Winter, Søren; T. Dinesen, Peter; J. May, Peter

    -government regimes foster greater policy commitment, attention to rules, and adherence among frontline workers than is the case for a local-government implementation regime. These lead to actions of street-level bureaucrats in central-government regimes that are more in line with national policies than those...

  14. Accommodating human values in the climate regime

    NARCIS (Netherlands)

    Cook, Rosalind; Tauschinsky, Eljalill

    2008-01-01

    The climate regime addresses one of the most important challenges facing humankind today. However, while the environmental and economic sides of the problem are well represented, it lacks the inclusion of social and human aspects. The human rights regime, in contrast, is a regime which has been esta

  15. Wilson fermions in the epsilon regime

    CERN Document Server

    Bär, Oliver; Schaefer, Stefan

    2009-01-01

    We extend the epsilon-expansion of continuum chiral perturbation theory to nonzero lattice spacing in the framework of Wilson Chiral Perturbation Theory. We distinguish various regimes by defining the relative power counting of the quark mass m and the lattice spacing a. We observe that for m ~ a Lambda^2_QCD, the explicit breaking of chiral symmetry in Wilson fermions is still driven by the quark mass and lattice corrections are highly suppressed. The lattice spacing effects become more pronounced for smaller quark masses and may lead to non-trivial corrections of the continuum results at next-to-leading order. We compute these corrections for standard current and density correlation functions. A fit to lattice data shows that these corrections are small, as expected.

  16. Is the Economic Crisis Challenging the Prevailing Gender Regime?

    DEFF Research Database (Denmark)

    Leschke, Janine; Jepsen, Maria

    2014-01-01

    This paper addresses the question of whether the current economic and financial crisis is challenging the prevailing gender-equality model in four European countries: Denmark, Germany, Slovakia, and the United Kingdom. After situating the countries in relation to the underlying gender regime...... and analysing the corresponding position of women and men in paid and unpaid work, the paper contains an in-depth discussion of the short- and medium-term policy responses to the crisis. Our analysis shows that independent of the prevailing gender regime, scant public attention has been directed to gender...

  17. Adaptation in Collaborative Governance Regimes

    Science.gov (United States)

    Emerson, Kirk; Gerlak, Andrea K.

    2014-10-01

    Adaptation and the adaptive capacity of human and environmental systems have been of central concern to natural and social science scholars, many of whom characterize and promote the need for collaborative cross-boundary systems that are seen as flexible and adaptive by definition. Researchers who study collaborative governance systems in the public administration, planning and policy literature have paid less attention to adaptive capacity specifically and institutional adaptation in general. This paper bridges the two literatures and finds four common dimensions of capacity, including structural arrangements, leadership, knowledge and learning, and resources. In this paper, we focus on institutional adaptation in the context of collaborative governance regimes and try to clarify and distinguish collaborative capacity from adaptive capacity and their contributions to adaptive action. We posit further that collaborative capacities generate associated adaptive capacities thereby enabling institutional adaptation within collaborative governance regimes. We develop these distinctions and linkages between collaborative and adaptive capacities with the help of an illustrative case study in watershed management within the National Estuary Program.

  18. Measuring the effectiveness of international environmental regimes

    Energy Technology Data Exchange (ETDEWEB)

    Helm, C.; Sprinz, D.F.

    1999-05-01

    While past research has emphasized the importance of international regimes for international governance, systematic assessments of regime effects are missing. This article derives a standardized measurement concept for the effectiveness of international environmental regimes by developing an operational rational choice calculus to evaluate actual policy simultaneously against a non-regime counterfactual and a collective optimum. Subsequently, the empirical feasibility of the measurement instrument is demonstrated by way of two international treaties regulating transboundary air pollution in Europe. The results demonstrate that the regimes indeed show positive effects - but fall substantially short of the collective optima. (orig.)

  19. British Columbia's new coalbed methane royalty regime

    Energy Technology Data Exchange (ETDEWEB)

    Molinski, D. [British Columbia Ministry of Energy and Mines, Victoria, BC (Canada). Energy and Minerals Div.

    2002-07-01

    The British Columbia Ministry of Energy and Mines is promoting the development of the coalbed methane (CBM) industry in the province in order to make CBM a viable and competitive investment option for industry. It is establishing a regulatory and fiscal regime for CBM development. Issues of concern regarding CBM development include water production, gas production rates, well numbers, and marginal economics. The features of the CBM royalty regime include a new producer cost of service allowance, the creation of a CBM royalty tax bank to collect excess PCOS allowances, and a royalty tax credit for wells drilled by the end of February, 2004. The marginal well adjustment factor threshold has been raised from 180 mcf per day to 600 mcf per day for CBM only. It was noted that royalties will probably not be payable for several years following the first commercial well because royalties are very depending on capital and operating costs, local infrastructure and price. Royalty regimes cannot save CBM from low gas prices, poor resources or economics. 2 figs.

  20. The difficulties of the Chinese and Indian exchange rate regimes

    Directory of Open Access Journals (Sweden)

    Ila Patnaik

    2009-06-01

    Full Text Available China and India have both sought control over the exchange rate in order to maintain export competitiveness, manage current account balance, and pursue independent monetary policy. In this paper, we examine structural change in the Chinese and Indian de facto exchange rate regimes, focusing on the period from 1998 to 2007. With increasing capital account openness, exchange rate inflexibility has been associated with significant monetary policy distortions. In both countries, the short-term rate expressed in real terms dropped, and achieved very low values, in the unprecedented business cycle expansion of the early 2000s. In the Indian case, difficulties of sterilisation led to a modification of the exchange rate regime, moving towards greater flexibility. In China, in contrast, the exchange rate regime did not change.

  1. Development of regulatory policy for SMART-P

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S. H.; Lee, Y. H.; Moo, Philip; Koh, B. J.; Son, M. K.; Han, G. H.; Kim, D. H. [Korea Association for Nuclear Technology, Daejeon (Korea, Republic of)

    2004-06-15

    KAERI promoted the construction of a research reactor, SMART-P, the reduced scale of SMART, with intent to demonstrate the safety and performance of SMART. According to this progress, the development of regulatory process for SMART-P became necessary. The establishment of regulatory policy, based on the current regulatory guidelines as well as technical aspect, became essential matters. Considering the on-going small and medium size reactors in near future, the selection of the appropriate measure in the existing regulatory process to SMART-P is very important. Thus the schematic study for the applicable licensing procedure and regulatory requirements suitable for SMART-P is required.

  2. Development of regulatory policy for SMART-P

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S. H.; Moon, S. H.; Lee, Y. H.; Son, M. K.; Han, K. H.; Kim, D. H. [Korea Association for Nuclear Technology, Taejon (Korea, Republic of)

    2003-06-15

    KAERI promoted the construction of a research reactor, SMART-P, the reduced scale of SMART, with intent to demonstrate the safety and performance of SMART. According to this progress, the development of regulatory process for SMART-P became necessary. The establishment of regulatory policy, based on the current regulatory guidelines as well as technical aspect, became essential matters. Considering the on-going small and medium size reactors m near future, the selection of the appropriate measure in the existing regulatory process to SMART-P is very important. Thus the schematic study for the applicable licensing procedure and regulatory requirements suitable for SMART-P is required.

  3. Regulating regulatory T cells.

    Science.gov (United States)

    Le, N T; Chao, N

    2007-01-01

    Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress activation of other immune cells and thereby maintain immune system homeostasis, self-tolerance as well as control excessive response to foreign antigens. The mere concept of Tregs was the subject of significant controversy among immunologists for many years owing to the paucity of reliable markers for defining these cells and the ambiguity of the nature and molecular basis of suppressive phenomena. However, recent advances in the molecular characterization of this cell population have firmly established their existence and their vital role in the vertebrate immune system. Of interest, accumulating evidence from both humans and experimental animal models has implicated the involvement of Tregs in the development of graft-versus-host disease (GVHD). The demonstration that Tregs could separate GVHD from graft-versus-tumor (GVT) activity suggests that their immunosuppressive potential could be manipulated to reduce GVHD without detrimental consequence on GVT effect. Although a variety of T lymphocytes with suppressive capabilities have been reported, the two best-characterized subsets are the naturally arising, intrathymic-generated Tregs (natural Tregs) and the peripherally generated, inducible Tregs (inducible Tregs). This review summarizes our current knowledge of the generation, function and regulation of these two populations of Tregs during an immune response. Their role in the development of GVHD and their therapeutic potential for the prevention and treatment of GVHD will also be described.

  4. Regime shifts in the Sahara and Sahel: interactions between ecological and climatic systems in northern Africa

    NARCIS (Netherlands)

    Foley, J.A.; Coe, M.T.; Scheffer, M.; Wang, G.L.

    2003-01-01

    The Sahara and Sahel regions of northern Africa have complex environmental histories punctuated by sudden and dramatic "regime shifts" in climate and ecological conditions. Here we review the current understanding of the causes and consequences of two environmental regime shifts in the Sahara and Sa

  5. Interacting Regional-Scale Regime Shifts for Biodiversity and Ecosystem Services

    NARCIS (Netherlands)

    Leadley, P.; Proenca, V.; Fernandez-Manjarres, J.; Pereira, H.M.; Alkemade, J.R.M.; Biggs, R.; Bruley, E.; Cheung, W.; Cooper, D.; Figueiredo, J.; Gilman, E.; Guenette, S.; Hurtt, G.; Mbow, C.; Oberdorff, T.; Revenga, C.; Scharlemann, J.P.W.; Scholes, R.; Smith, M.S.; Sumaila, U.R.; Walpole, M.

    2014-01-01

    Current trajectories of global change may lead to regime shifts at regional scales, driving coupled human-environment systems to highly degraded states in terms of biodiversity, ecosystem services, and human well-being. For business-as-usual socioeconomic development pathways, regime shifts are proj

  6. Historical disturbance regimes as a reference for forest policy. in a multiowner province: a simulation experiment

    Science.gov (United States)

    Jonathan R. Thompson; K. Norman Johnson; Marie Lennette; Thomas A. Spies; Pete Bettinger

    2006-01-01

    Using a landscape simulation model, we examined ecological and economic implications of forest policies designed to emulate the historical fire regime across the 2 x 106 ha Oregon Coast Range. Simulated policies included two variants of the current policy and three policies reflecting aspects of the historical fire regime. Policy development was...

  7. Real time estimates of GDP growth, based on two regime models

    NARCIS (Netherlands)

    Groot, de E.A. (Bert); Franses, P.H.P.H.

    2005-01-01

    This paper builds on De Groot and Franses (2005) (Econometric Institute Report 2005-01). It modifies the EICIE, the Econometric Institute Current Indicator of the Economy, by allowing for two regimes. These regimes are marked by positive or negative annual growth in the staffing services data. Real

  8. Real time estimates of GDP growth, based on two-regime models

    NARCIS (Netherlands)

    E.A. de Groot (Bert); Ph.H.B.F. Franses (Philip Hans)

    2005-01-01

    textabstractThis paper builds on De Groot and Franses (2005) (Econometric Institute Report 2005-01). It modifies the EICIE, the Econometric Institute Current Indicator of the Economy, by allowing for two regimes. These regimes are marked by positive or negative annual growth in the staffing services

  9. Interacting Regional-Scale Regime Shifts for Biodiversity and Ecosystem Services

    NARCIS (Netherlands)

    Leadley, P.; Proenca, V.; Fernandez-Manjarres, J.; Pereira, H.M.; Alkemade, J.R.M.; Biggs, R.; Bruley, E.; Cheung, W.; Cooper, D.; Figueiredo, J.; Gilman, E.; Guenette, S.; Hurtt, G.; Mbow, C.; Oberdorff, T.; Revenga, C.; Scharlemann, J.P.W.; Scholes, R.; Smith, M.S.; Sumaila, U.R.; Walpole, M.

    2014-01-01

    Current trajectories of global change may lead to regime shifts at regional scales, driving coupled human-environment systems to highly degraded states in terms of biodiversity, ecosystem services, and human well-being. For business-as-usual socioeconomic development pathways, regime shifts are proj

  10. Hall effect in hopping regime

    Energy Technology Data Exchange (ETDEWEB)

    Avdonin, A., E-mail: avdonin@ifpan.edu.pl [Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warszawa (Poland); Skupiński, P. [Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warszawa (Poland); Grasza, K. [Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warszawa (Poland); Institute of Electronic Materials Technology, ul. Wólczyńska 133, 01-919 Warszawa (Poland)

    2016-02-15

    A simple description of the Hall effect in the hopping regime of conductivity in semiconductors is presented. Expressions for the Hall coefficient and Hall mobility are derived by considering averaged equilibrium electron transport in a single triangle of localization sites in a magnetic field. Dependence of the Hall coefficient is analyzed in a wide range of temperature and magnetic field values. Our theoretical result is applied to our experimental data on temperature dependence of Hall effect and Hall mobility in ZnO. - Highlights: • Expressions for Hall coefficient and mobility for hopping conductivity are derived. • Theoretical result is compared with experimental curves measured on ZnO. • Simultaneous action of free and hopping conduction channels is considered. • Non-linearity of hopping Hall coefficient is predicted.

  11. A study on the development of nuclear policy to respond to international non-proliferation regimes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Wook; Oh, K. B.; Yang, M. H.; Lee, H. M.; Ko, H. S.; Ryu, J. S.; Jung, W. H.; Lim, C. Y

    2006-01-15

    This study analyzed the trends of the nonproliferation regimes in the following three aspects. First, this study analyzed the trends of the international nuclear non-proliferation regime, which includes the NPT, the IAEA safeguards system, the international nuclear export control regime and multilateral nuclear approach. Second, this study forecast the future trends of the nonproliferation systems with the reflection of current international situations. Third, this study also analyzed outstanding issues in nuclear control regimes and derived some factors to reflect national nuclear foreign policy.

  12. Safety management, under different regimes

    Energy Technology Data Exchange (ETDEWEB)

    Weibye, B.S. [Norske Veritas, Oslo (Norway)

    1996-12-31

    The paper relates to safety management in the North Sea. This presentation will look at the interplay between the forces and factors driving political authorities representing the interest of society on one side and the owners/operators on the other. The maturation process or evolution from a prescriptive to an objective approach will be examined both in Norway with the implementation of the Internal Control philosophy and using the Piper Alpha disaster, Lord Cullen`s public Inquiry and the subsequent enactment of the Offshore Safety Case in the UK as case examples. The impact these regulatory changes had on the Safety Management Systems of operators in the Norwegian and UK sectors of the North Sea will be outlined. Finally the transitions in the North Sea will be examined to determine if they can if they can be used as a model for exporting to other ares or countries. 4 refs.

  13. Global fishery prospects under contrasting management regimes

    Science.gov (United States)

    Costello, Christopher; Ovando, Daniel; Clavelle, Tyler; Strauss, C. Kent; Hilborn, Ray; Melnychuk, Michael C.; Branch, Trevor A.; Gaines, Steven D.; Szuwalski, Cody S.; Cabral, Reniel B.; Rader, Douglas N.; Leland, Amanda

    2016-01-01

    Data from 4,713 fisheries worldwide, representing 78% of global reported fish catch, are analyzed to estimate the status, trends, and benefits of alternative approaches to recovering depleted fisheries. For each fishery, we estimate current biological status and forecast the impacts of contrasting management regimes on catch, profit, and biomass of fish in the sea. We estimate unique recovery targets and trajectories for each fishery, calculate the year-by-year effects of alternative recovery approaches, and model how alternative institutional reforms affect recovery outcomes. Current status is highly heterogeneous—the median fishery is in poor health (overfished, with further overfishing occurring), although 32% of fisheries are in good biological, although not necessarily economic, condition. Our business-as-usual scenario projects further divergence and continued collapse for many of the world’s fisheries. Applying sound management reforms to global fisheries in our dataset could generate annual increases exceeding 16 million metric tons (MMT) in catch, $53 billion in profit, and 619 MMT in biomass relative to business as usual. We also find that, with appropriate reforms, recovery can happen quickly, with the median fishery taking under 10 y to reach recovery targets. Our results show that commonsense reforms to fishery management would dramatically improve overall fish abundance while increasing food security and profits. PMID:27035953

  14. Regulatory guidance document

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-05-01

    The Office of Civilian Radioactive Waste Management (OCRWM) Program Management System Manual requires preparation of the OCRWM Regulatory Guidance Document (RGD) that addresses licensing, environmental compliance, and safety and health compliance. The document provides: regulatory compliance policy; guidance to OCRWM organizational elements to ensure a consistent approach when complying with regulatory requirements; strategies to achieve policy objectives; organizational responsibilities for regulatory compliance; guidance with regard to Program compliance oversight; and guidance on the contents of a project-level Regulatory Compliance Plan. The scope of the RGD includes site suitability evaluation, licensing, environmental compliance, and safety and health compliance, in accordance with the direction provided by Section 4.6.3 of the PMS Manual. Site suitability evaluation and regulatory compliance during site characterization are significant activities, particularly with regard to the YW MSA. OCRWM`s evaluation of whether the Yucca Mountain site is suitable for repository development must precede its submittal of a license application to the Nuclear Regulatory Commission (NRC). Accordingly, site suitability evaluation is discussed in Chapter 4, and the general statements of policy regarding site suitability evaluation are discussed in Section 2.1. Although much of the data and analyses may initially be similar, the licensing process is discussed separately in Chapter 5. Environmental compliance is discussed in Chapter 6. Safety and Health compliance is discussed in Chapter 7.

  15. Policy and Regulatory Issues for Underground Coal Gasification in India

    Science.gov (United States)

    Singh, Sunil K.

    2017-07-01

    Underground coal gasification (UCG) is in its nascent stage of development. Most of the projects are in the nature of pilot projects. UCG technology requires acceptance in general commercial framework as it matures with the progress of time. Policy and regulatory framework, therefore, is considered here only in the expectation that UCG technology may finally be rolled out sooner than later. India is actively pursuing consultations with major countries which have recorded successes in implementing UCG technology in varying measures. In this background, the discussion on policy and regulatory framework is essentially an effort to capture the broad outline of the understanding of the UCG process in a regulatory construct as compared with other regulatory regimes of similar nature.

  16. The seismotectonic regime in Greece

    Directory of Open Access Journals (Sweden)

    GALANOPOULOS A. G.

    1967-06-01

    Full Text Available Evidence is presented which favours the theory that the
    earthquake activity in the area of Greece should bo ascribed to horizontal currents flowing off to the side of the secondary sedimentary arc, from a minor mantle current rising under the primary volcanic arc of the Southeastern section of the Dinaric Alps.

  17. Equilibrium yield curves under regime switching

    OpenAIRE

    García-Verdú, Santiago

    2010-01-01

    This paper studies how inflation as a macroeconomic indicator affects nominal bond prices. I consider an economy with a representative agent with Epstein- Zin preferences. Regime switching affects the state-space capturing inflation and consumption growth. Thus, the agent is concerned about the intertemporal distribution of risk, which is affected by the persistence of the variables and the regimes. Regime switching allows for structural changes in the volatility of unexpected shocks. To the ...

  18. How will climate change modify river flow regimes in Europe?

    Directory of Open Access Journals (Sweden)

    C. Schneider

    2013-01-01

    Full Text Available Worldwide, flow regimes are being modified by various anthropogenic impacts and climate change induces an additional risk. Rising temperatures, declining snow cover and changing precipitation patterns will interact differently at different locations. Consequently, in distinct climate zones, unequal consequences can be expected in matters of water stress, flood risk, water quality, and food security. In particular, river ecosystems and their vital ecosystem services will be compromised as their species richness and composition have evolved over long time under natural flow conditions. This study aims at evaluating the exclusive impacts of climate change on river flow regimes in Europe. Various flow characteristics are taken into consideration and diverse dynamics are identified for each distinct climate zone in Europe. In order to simulate present-day natural flow regimes and future flow regimes under climate change, the global hydrology model WaterGAP3 is applied. All calculations for current and future conditions (2050s are carried out on a 5' × 5' European grid. To address uncertainty, bias-corrected climate forcing data of three different global climate models are used to drive WaterGAP3. Finally, the hydrological alterations of different flow characteristics are quantified by the Indicators of Hydrological Alteration approach. Results of our analysis indicate that on the European scale, climate change can be expected to modify flow regimes remarkably. This is especially the case in the Mediterranean (due to drier conditions with reduced precipitation across the year and in the boreal climate zone (due to reduced snowmelt, increased precipitation, and strong temperature rises. In the temperate climate zone, impacts increase from oceanic to continental. Regarding single flow characteristics, strongest impacts on timing were found for the boreal climate zone. This applies for both high and low flows. Flow magnitudes, in turn, will be

  19. Thermal regime of Negotinska Krajina

    Directory of Open Access Journals (Sweden)

    Živković Ljiljana

    2005-01-01

    Full Text Available Negotin Krajina geographically belongs to Mezian tablet that means it is widely open to the influences from the East but main air influences come from the West and North-West causes specific thermal characteristics. Meteorological station "Negotin" is the only one respectable station in the Krajina then we analyze results from various periods since 1901. It is important to emphasize that station "Negotin" doesn't have work continuity since the beginning of the century, thus for analyzing certain climate elements we have had to use method of analogy with station "Zaječar". A part of that, observations were not done by the same methodology so there is lack of some important indicators for this first period. To determine air thermo-regime of Negotin Krajina during 20 century, standard periods (1901-1930., 1931-1960. and 1961-1990 for analyzing climate elements suggested by WMO, were compared. Also, periods from 1925. to 1940. and from 1990. to 2000. were added to this analysis (according to data we had.

  20. Safeguards inventory and process monitoring regulatory comparison

    Energy Technology Data Exchange (ETDEWEB)

    Cavaluzzi, Jack M. [Texas A & M Univ., College Station, TX (United States); Gibbs, Philip W. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2013-06-27

    Detecting the theft or diversion of the relatively small amount of fissile material needed to make a nuclear weapon given the normal operating capacity of many of today’s running nuclear production facilities is a difficult task. As throughput increases, the ability of the Material Control and Accountability (MC&A) Program to detect the material loss decreases because the statistical measurement uncertainty also increases. The challenge faced is the ability of current accounting, measurement, and material control programs to detect small yet significant losses under some regulatory approaches can decrease to the point where it is extremely low if not practically non-existent at normal operating capacities. Adding concern to this topic is that there are variations among regulatory bodies as far as what is considered a Significant Quantity (SQ). Some research suggests that thresholds should be lower than those found in any current regulation which if adopted would make meeting detection goals even more difficult. This paper reviews and compares the current regulatory requirements for the MA elements related to physical inventory, uncertainty of the Inventory Difference (ID), and Process Monitoring (PM) in the United States Department of Energy (DOE) and Nuclear Regulatory Commission (NRC), Rosatom of the Russian Federation and the Chinese Atomic Energy Agency (CAEA) of China. The comparison looks at how the regulatory requirements for the implementation of various MA elements perform across a range of operating capacities in example facilities.

  1. Regulatory T cell memory

    Science.gov (United States)

    Rosenblum, Michael D.; Way, Sing Sing; Abbas, Abul K.

    2016-01-01

    Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte populations show an increase in number and function after antigen encounter and more rapidly re-expand upon subsequent antigen exposure. Studies of immune memory have primarily focused on effector B cells and T cells with microbial specificity, using prime challenge models of infection. However, recent work has also identified persistently expanded populations of antigen-specific regulatory T cells that protect against aberrant immune responses. In this Review, we consider the parallels between memory effector T cells and memory regulatory T cells, along with the functional implications of regulatory memory in autoimmunity, antimicrobial host defence and maternal fetal tolerance. In addition, we discuss emerging evidence for regulatory T cell memory in humans and key unanswered questions in this rapidly evolving field. PMID:26688349

  2. Regimes of the electron diffusion region in magnetic reconnection.

    Science.gov (United States)

    Le, A; Egedal, J; Ohia, O; Daughton, W; Karimabadi, H; Lukin, V S

    2013-03-29

    The electron diffusion region during magnetic reconnection lies in different regimes depending on the pressure anisotropy, which is regulated by the properties of thermal electron orbits. In kinetic simulations at the weakest guide fields, pitch angle mixing in velocity space causes the outflow electron pressure to become nearly isotropic. Above a threshold guide field that depends on a range of parameters, including the normalized electron pressure and the ion-to-electron mass ratio, electron pressure anisotropy develops in the exhaust and supports extended current layers. This new regime with electron current sheets extending to the system size is also reproduced by fluid simulations with an anisotropic closure for the electron pressure. It offers an explanation for recent spacecraft observations.

  3. Recommendations on legislative and regulatory framework and regulatory body of nuclear security in China

    Institute of Scientific and Technical Information of China (English)

    PU Jilong; LI Xiaoyan

    2007-01-01

    This paper describes the definition of nuclear security that has been changing from the cold war age to the post-911 period, and clarifies the close relationship and yet a clear distinction between nuclear security, nuclear safety and nuclear safeguard. Based on analyses of the current state of nuclear security activities in China as well as the requirements and the law infrastructure, a legislative and regulatory framework of nuclear security and the mandate of a regulatory body in China are recommended.

  4. Nano-plasmonic antennas in the near infrared regime.

    Science.gov (United States)

    Berkovitch, N; Ginzburg, P; Orenstein, M

    2012-02-22

    Plasmonic nano-antennas constitute a central research topic in current science and engineering with an enormous variety of potential applications. Here we review the recent progress in the niche of plasmonic nano-antennas operating in the near infrared part of the spectrum which is important for a variety of applications. Tuning of the resonance into the near infrared regime is emphasized in the perspectives of fabrication, measurement, modeling, and analytical treatments, concentrating on the vast recent achievements in these areas.

  5. Crustal stress regime in Italy

    Directory of Open Access Journals (Sweden)

    M. Cesaro

    1997-06-01

    Full Text Available In order to obtain a reliable map of the present-day stress field in Italy, needed to better understand the active tectonic processes and to contribute to the assessment of seismic hazard, in 1992 we started to collect and analyze new data from borehole breakouts in deep oil and geothermal wells and focal mechanisms of earthquakes (2.5 < M <5 occurred in Italy between 1988 and 1995. From about 200 deep wells and 300 focal mechanisms analyzed to date, we infer that: the internal (SW sector of the Northern Apenninic arc is extending with minimum compressional stress (Shmin oriented ? ENE, while the external front is thrusting over the Adriatic foreland (Shmin ? NW-SE. The entire Southern Apennine is extending in NE direction (from the Tyrrhenian margin to the Apulian foreland and compression (in the foredeep is no longer active at the outer (NE thrust front. Between these two arcs, an abrupt change in the tectonic regime is detected with directions of horizontal stress changing by as much as 90º in the external front, around latitude 430N. Along the Ionian side of the Calabrian arc the stress directions inferred from breakouts and focal mechanisms are scattered with a hint of rotation from N-S Shmin close to the Southern Apennines, to ~ E-W directions in the Messina Strait. In Sicily, a NW-SE direction of SHmax is evident in the Hyblean foreland, parallel to the direction of plate motion between Africa and Europe. A more complex pattern of stress directions is observed in the thrust belt zone, with rotations from the regional trend (NW í directed SHmax to NE oriented SHmax. A predominant NW direction of SHmax is also detected in mainland Sicily from earthquake focal mechanisms, but no well data are available in this region. In the northern part of Sicily (Aeolian Islands a ~N-S direction of SHmax is observed.

  6. Multiscale regime shifts and planetary boundaries

    NARCIS (Netherlands)

    Hughes, T.P.; Carpenter, S.; Rockstrom, J.; Scheffer, M.; Walker, B.

    2013-01-01

    Life on Earth has repeatedly displayed abrupt and massive changes in the past, and there is no reason to expect that comparable planetary-scale regime shifts will not continue in the future. Different lines of evidence indicate that regime shifts occur when the climate or biosphere transgresses a ti

  7. LEGAL MATRIMONIAL REGIME IN B&H

    Directory of Open Access Journals (Sweden)

    Boris Krešić

    2011-12-01

    Full Text Available Matrimonial regime between spouses or between extramarital partners, and between parents and children is regulated by the Family Law Act of Bosnia and Herzegovina Federation, hereinafter FLA B&HF (SG FBiH 35/05, 41/05, Family Law Act of the Republic of Srpska, hereinafter FLA RS (SG RS”54/02, 41/08 and the Family Law Act of Brčko District, hereinafter FLA BD (SG RS, 66/07. Legal rules used for the regulation of the matrimonial regime between spouses, as well as between spouses and third parties make matrimonial regime (Ponjavić, 2005, p. 361. Matrimonial regime between spouses in family legislation in Bosnia and Herzegovina (B&H is regulated in two following ways: as legal matrimonial regime and as contract matrimonial regime. Legal regime is the one which applies on spouses if not arranged otherwise prior to contracting marriage or during marriage. In this paper the author indicates the differences between the legal matrimonial regimes of the two entities as well as those between the entities and Brčko District of Bosnia and Herzegovina.

  8. LOW DOSE MAGNESIUM SULPHATE REGIME FOR ECLAMPSIA

    Directory of Open Access Journals (Sweden)

    Bangal V

    2009-09-01

    Full Text Available Pre- eclampsia is one of the commonest medical complications seen during pregnancy. It contributes significantly to maternal and perinatal morbidity and mortality. Dr.J.A.Pritchard in 1955, introduced magnesium sulphate for control of convulsions in eclampsia and is used worldwide. Considering the low body mass index of indian women, a low dose magnesium sulphate regime has been introduced by some authors. Present study was carried out at tertiary care centre in rural area. Fifty cases of eclampsia were randomly selected to find out the efficacy of low dose magnesium sulphate regime to control eclamptic convulsions. Maternal and perinatal outcome and magnesium toxicity were analyzed. It was observed that 86% cases responded to initial intravenous dose of 4 grams of 20% magnesium sulphate . Eight percent cases, who got recurrence of convulsion, were controlled by additional 2 grams of 20% magnesium sulphate. Six percent cases required shifting to standard Pritchard regime, as they did not respond to low dose magnesium sulphate regime. The average total dose of magnesium sulphate required for control of convulsions was 20 grams ie. 54.4% less than that of standard Pritchard regime. The maternal and perinatal morbidity and mortality in the present study werecomparable to those of standard Pritchard regime. The study did not find a single case of magnesium related toxicity with low dose magnesium sulphate regime. Low dose magnesium sulphate regime was found to be safe and effective in eclampsia.

  9. Analysis of thermionic bare tether operation regimes in passive mode

    Science.gov (United States)

    Sanmartín, J. R.; Chen, Xin; Sánchez-Arriaga, G.

    2017-01-01

    A thermionic bare tether (TBT) is a long conductor coated with a low work-function material. In drag mode, a tether segment extending from anodic end A to a zero-bias point B, with the standard Orbital-motion-limited current collection, is followed by a complex cathodic segment. In general, as bias becomes more negative in moving from B to cathodic end C, one first finds space-charge-limited (SCL) emission covering up to some intermediate point B*, then full Richardson-Dushman (RD) emission reaching from B* to end C. An approximate analytical study, which combines the current and voltage profile equations with results from asymptotic studies of the Vlasov-Poisson system for emissive probes, is carried out to determine the parameter domain covering two limit regimes, which are effectively controlled by just two dimensionless parameters involving ambient plasma and TBT material properties. In one such limit regime, no point B* is reached and thus no full RD emission develops. In an opposite regime, SCL segment BB* is too short to contribute significantly to the current balance.

  10. 專利間接侵權之制度規範:我國判決實證研究與法制建議 Legal Regimes on Indirect Patent Infringement: Empirical Studies of Taiwanese Judicial Decisions and Regulatory Recommendations

    Directory of Open Access Journals (Sweden)

    王立達 Richard Li-Dar Wang

    2016-01-01

    Full Text Available 專利間接侵權,係以誘引或輔助他人侵害專利之方式,損害專利權之行為。為確保專利保護之實效性,美、日與英、德等歐洲國家專利法均設有間接侵權規定,將侵害專利風險較高之特定間接行為,於直接侵權之外另設獨立規範課以侵權責任。我國迄今尚未將間接侵權納入專利法規範,本文分析美國、歐洲兩大陣營間接侵權制度之構成要件設計,作為本土研究之參照基礎,並且據以分析智慧局曾經提出之間接侵權草案條文。在現行法下,國內學說實務均肯認專利間接侵害得以民法第185 條之造意或幫助等共同侵權行為予以課責。為究明我國目前實際規範狀態,本文針對10 年來專利共同侵權之法院判決進行實證研究。調查結果顯示,我國司法實務上主張間接侵權與認定成立之案件數量均甚為稀少。法院對於間接侵權責任採取從屬於直接侵權之立場;然而,對於間接侵權是否以故意為必要,以及所涵蓋的幫助行為範圍,各法院立場分歧,其見解亦不無有待斟酌之處。為彌補司法實務因直接侵權人無過失,從屬免除間接侵權人之侵權責任,導致間接侵權人即使蓄意引發專利侵權,仍無須為之負責的專利保護真空狀態,我國專利法應明文設置間接侵權之規範條文,並且參照國外法制經驗,妥善設計其涵蓋範圍與構成要件,避免間接侵權責任過於廣泛,以導引本制度之良善發展。 The indirect infringement of patents denotes that the actor contributes to or actively induces patent infringements finished up by others, so that contravening indirectly the exclusive rights of patentees. For the purpose of assuring effective patent protection, countries such as the United States, Japan, United Kingdom and Germany all have instituted legal regimes addressing this type of patent infringement

  11. Anticipating regime shifts in gene expression: The case of an autoactivating positive feedback loop

    Science.gov (United States)

    Sharma, Yogita; Dutta, Partha Sharathi; Gupta, A. K.

    2016-03-01

    Considerable evidence suggests that anticipating sudden shifts from one state to another in bistable dynamical systems is a challenging task; examples include ecosystems, financial markets, and complex diseases. In this paper, we investigate the effects of additive, multiplicative, and cross-correlated stochastic perturbations on determining the regime shifts in a bistable gene regulatory system, which gives rise to two distinct states of low and high concentrations of protein. We obtain the stationary probability density and mean first-passage time of the system. We show that increasing the additive (multiplicative) noise intensity induces a regime shift from a low (high) to a high (low) protein concentration state. However, an increase in the cross-correlation intensity always induces regime shifts from a high to a low protein concentration state. For both bifurcation-induced (often called the tipping point) and noise-induced (called stochastic switching) regime shifts, we further explore the robustness of recently developed critical-down-based early warning signal (EWS) indicators (e.g., rising variance and lag-1 autocorrelation) on our simulated time-series data. We identify that using EWS indicators, prediction of an impending bifurcation-induced regime shift is relatively easier than that of a noise-induced regime shift in the considered system. Moreover, the success of EWS indicators also strongly depends upon the nature of the noise.

  12. Department of Agriculture Semiannual Regulatory Agenda

    Science.gov (United States)

    2010-04-26

    ... members of the public have advocated for amending the regulations for sourcing dairy replacement animals. They have asserted that the current regulatory language on sourcing dairy replacement animals lacks... Order for dairy product promotion, research, and nutrition education as part of a comprehensive strategy...

  13. Assessment of Global Variability in UTBB MOSFETs in Subthreshold Regime

    Directory of Open Access Journals (Sweden)

    Sergej Makovejev

    2014-07-01

    Full Text Available The global variability of ultra-thin body and buried oxide (UTBB MOSFETs in subthreshold and off regimes of operation is analyzed. The variability of the off-state drain current, subthreshold slope, drain-induced barrier lowering (DIBL, gate leakage current, threshold voltage and their correlations are considered. Two threshold voltage extraction techniques were used. It is shown that the transconductance over drain current (gm/Id method is preferable for variability studies. It is demonstrated that the subthreshold drain current variability in short channel devices cannot be described by threshold voltage variability. It is suggested to include the effective body factor incorporating short channel effects in order to properly model the subthreshold drain current variability.

  14. Revised analyses of decommissioning for the reference pressurized Water Reactor Power Station. Volume 2, Effects of current regulatory and other considerations on the financial assurance requirements of the decommissioning rule and on estimates of occupational radiation exposure: Appendices, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Konzek, G.J.; Smith, R.I.; Bierschbach, M.C.; McDuffie, P.N.

    1995-11-01

    With the issuance of the final Decommissioning Rule (July 27, 1998), owners and operators of licensed nuclear power plants are required to prepare, and submit to the US Nuclear Regulatory Commission (NRC) for review, decommissioning plans and cost estimates. The NRC staff is in need of bases documentation that will assist them in assessing the adequacy of the licensee submittals, from the viewpoint of both the planned actions, including occupational radiation exposure, and the probable costs. The purpose of this reevaluation study is to provide some of the needed bases documentation. This report contains the results of a review and reevaluation of the 1978 PNL decommissioning study of the Trojan nuclear power plant (NUREG/CR-0130), including all identifiable factors and cost assumptions which contribute significantly to the total cost of decommissioning the nuclear power plant for the DECON, SAFSTOR, and ENTOMB decommissioning alternatives. These alternatives now include an initial 5--7 year period during which time the spent fuel is stored in the spent fuel pool, prior to beginning major disassembly or extended safe storage of the plant. Included for information (but not presently part of the license termination cost) is an estimate of the cost to demolish the decontaminated and clean structures on the site and to restore the site to a ``green field`` condition. This report also includes consideration of the NRC requirement that decontamination and decommissioning activities leading to termination of the nuclear license be completed within 60 years of final reactor shutdown, consideration of packaging and disposal requirements for materials whose radionuclide concentrations exceed the limits for Class C low-level waste (i.e., Greater-Than-Class C), and reflects 1993 costs for labor, materials, transport, and disposal activities.

  15. Revised analyses of decommissioning for the reference pressurized Water Reactor Power Station. Effects of current regulatory and other considerations on the financial assurance requirements of the decommissioning rule and on estimates of occupational radiation exposure, Volume 1, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Konzek, G.J.; Smith, R.I.; Bierschbach, M.C.; McDuffie, P.N. [Pacific Northwest Lab., Richland, WA (United States)

    1995-11-01

    With the issuance of the final Decommissioning Rule (July 27, 1988), owners and operators of licensed nuclear power plants are required to prepare, and submit to the US Nuclear Regulatory Commission (NRC) for review, decommissioning plans and cost estimates. The NRC staff is in need of bases documentation that will assist them in assessing the adequacy of the licensee submittals, from the viewpoint of both the planned actions, including occupational radiation exposure, and the probable costs. The purpose of this reevaluation study is to provide some of the needed bases documentation. This report contains the results of a review and reevaluation of the {prime}978 PNL decommissioning study of the Trojan nuclear power plant (NUREG/CR-0130), including all identifiable factors and cost assumptions which contribute significantly to the total cost of decommissioning the nuclear power plant for the DECON, SAFSTOR, and ENTOMB decommissioning alternatives. These alternatives now include an initial 5--7 year period during which time the spent fuel is stored in the spent fuel pool, prior to beginning major disassembly or extended safe storage of the plant. Included for information (but not presently part of the license termination cost) is an estimate of the cost to demolish the decontaminated and clean structures on the site and to restore the site to a ``green field`` condition. This report also includes consideration of the NRC requirement that decontamination and decommissioning activities leading to termination of the nuclear license be completed within 60 years of final reactor shutdown, consideration of packaging and disposal requirements for materials whose radionuclide concentrations exceed the limits for Class C low-level waste (i.e., Greater-Than-Class C), and reflects 1993 costs for labor, materials, transport, and disposal activities.

  16. The human dimension of fire regimes on Earth

    Science.gov (United States)

    Bowman, David M.J.S.; Balch, Jennifer; Artaxo, Paulo; Bond, William J.; Cochrane, Mark A.; D'Antonio, Carla M.; DeFries, Ruth; Johnston, Fay H.; Keeley, Jon E.; Krawchuk, Meg A.; Kull, Christian A.; Michelle, Mack; Moritz, Max A.; Pyne, Stephen; Roos, Christopher I.; Scott, Andrew C.; Sodhi, Navjot S.; Swetnam, Thomas W.

    2011-01-01

    Humans and their ancestors are unique in being a fire-making species, but 'natural' (i.e. independent of humans) fires have an ancient, geological history on Earth. Natural fires have influenced biological evolution and global biogeochemical cycles, making fire integral to the functioning of some biomes. Globally, debate rages about the impact on ecosystems of prehistoric human-set fires, with views ranging from catastrophic to negligible. Understanding of the diversity of human fire regimes on Earth in the past, present and future remains rudimentary. It remains uncertain how humans have caused a departure from 'natural' background levels that vary with climate change. Available evidence shows that modern humans can increase or decrease background levels of natural fire activity by clearing forests, promoting grazing, dispersing plants, altering ignition patterns and actively suppressing fires, thereby causing substantial ecosystem changes and loss of biodiversity. Some of these contemporary fire regimes cause substantial economic disruptions owing to the destruction of infrastructure, degradation of ecosystem services, loss of life, and smoke-related health effects. These episodic disasters help frame negative public attitudes towards landscape fires, despite the need for burning to sustain some ecosystems. Greenhouse gas-induced warming and changes in the hydrological cycle may increase the occurrence of large, severe fires, with potentially significant feedbacks to the Earth system. Improved understanding of human fire regimes demands: (1) better data on past and current human influences on fire regimes to enable global comparative analyses, (2) a greater understanding of different cultural traditions of landscape burning and their positive and negative social, economic and ecological effects, and (3) more realistic representations of anthropogenic fire in global vegetation and climate change models. We provide an historical framework to promote understanding

  17. How will climate change modify river flow regimes in Europe?

    Directory of Open Access Journals (Sweden)

    C. Schneider

    2012-08-01

    Full Text Available Worldwide, flow regimes are being modified by various anthropogenic impacts and climate change induces an additional risk. Rising evapotranspiration rates, declining snow cover and changing precipitation patterns will interact differently at different locations. Consequently, in distinct climate zones, unequal consequences can be expected in matters of water stress, flood risk, water quality, and food security. In particular, river ecosystems and their vital ecosystem services will be compromised as their species richness and composition have evolved over long time under natural flow conditions. This study aims at evaluating the exclusive impacts of climate change on river flow regimes in Europe. Various flow characteristics are taken into consideration and diverse dynamics are identified for each distinct climate zone in Europe. In order to simulate natural and modified flow regimes, the global hydrology model WaterGAP3 is applied. All calculations for current and future conditions (2050s are carried out on a 5' × 5' European grid. To address uncertainty, climate forcing data of three different global climate models are used to drive WaterGAP3. Finally, the hydrological alterations of different flow characteristics are quantified by the Indicators of Hydrological Alteration approach. Results of our analysis indicate that on European scale, climate change can be expected to modify flow regimes significantly. This is especially the case in the Mediterranean climate zone (due to drier conditions with reduced precipitation across the year and in the continental climate zone (due to reduced snowmelt and drier summers. Regarding single flow characteristics, strongest impacts on timing were found for the boreal climate zone. This applies for both, high and low flows. While low flow magnitudes are likely to be stronger influenced in the Mediterranean climate, high flow magnitudes will be mainly altered in snow climates with warmer summers. At the end

  18. Rationales for regulatory activity

    Energy Technology Data Exchange (ETDEWEB)

    Perhac, R.M. [Univ. of Tennessee, Knoxville, TN (United States)

    1997-02-01

    The author provides an outline which touches on the types of concerns about risk evaluation which are addressed in the process of establishing regulatory guides. Broadly he says regulatory activity serves three broad constituents: (1) Paternalism (private risk); (2) Promotion of social welfare (public risks); (3) Protection of individual rights (public risks). He then discusses some of the major issues encountered in reaching a decision on what is an acceptable level of risk within each of these areas, and how one establishes such a level.

  19. Simulating Water Markets to Help Design Water Rights Regimes

    Science.gov (United States)

    Harou, J. J.; Erfani, T.; Huskova, I.; Binions, O.

    2012-12-01

    In many catchments in England no further licenses are available from the Environmental regulator that provides them. The possibility of trading water between license holders has been recognized as a potentially effective and economically efficient strategy to mitigate increasing scarcity. Although trading licenses has been possible since several years, it very rarely happens (roughly 50 trades in 8 years). Several barriers to trade exist including lack of sufficient and prolonged scarcity, license-holder unwillingness to risk future renewal, likelihood license will be downgraded during a trade, duration of time required for approving a trade, etc. Regulators seek to make policy changes so that their inability to grant new licenses will not harm the local and national economy. What policy changes will most cost-effectively increase trading and allow it to effectively reduce the economic cost of scarcity events? A screening tool that could help evaluate problems and advantages of different regulatory solutions, and that could serve to test, assuming transaction costs can be quantified, their effect on trading under specific conditions would be useful. We propose such a water market simulator that predicts economically efficient pair-wise trade (between willing buyers and sellers) and represents the interaction of trades with natural hydrological flows, engineered infrastructure and a particular regulatory regime. The model emulates license-holders' willingness to engage in short-term trade transactions. In their initial form different 'agents' (license holders) are represented using an economic benefit function of water use which is supplemented by rules to represent behavioral or other characteristics of realistic system behavior. A case study based on the river Ouse basin (UK) is made to test the model. The model simulates the catchment weekly over several years considering reservoirs and pair-wise specific transaction costs. Several regulatory policies are tested

  20. Upstream petroleum licensing: a comparative approach on regulatory frameworks and economic impacts

    Energy Technology Data Exchange (ETDEWEB)

    Cunha, Amanda L. [Felsberg e Associados, Sao Paulo, SP (Brazil)

    2008-07-01

    The recent discoveries hit in the pre-salt area, such as Tupi, Jupiter, Bem-te-vi and Carioca may place Brazil amongst the largest oil producers in the world. As a result, the Brazilian regulatory framework, which was originally envisaged in a scenario of higher exploration risk, has been under heavy public scrutiny. The Brazilian Government has already taken the first steps towards substantial changes in the country's contracting model for upstream activities. By means of Resolution No. 6/2007, the National Council for Energy Policy ('CNPE') not only determined the removal of 41 blocks with sub-salt geology from the ANP 9 Th Bid Round, but also stressed the need for a different regime for E and P activities in the country's continental shelf. At this moment, there is a great deal of controversy on the contracting model to be adopted, mainly whether the concession model should be maintained, but subject to higher levels of government take, or a production sharing model should apply. This paper goes through the evolution of international oil agreements, from early concessions to modern agreements. A special emphasis is placed on concession/license regimes as well as on production sharing agreements (PSAs). Besides drawing a comparative line between such models, this article assesses their economic impacts and whether the regulatory framework currently in force in Brazil is suitable for a scenario of lower risk, showing that any desired level of regulation may be achieved in the context of a PSA as easily as in a exclusive concession. (author)

  1. The short bunch blow-out regime in RF photoinjectors

    Energy Technology Data Exchange (ETDEWEB)

    Serafini, L. [INFN and Universita di Milano, Via Celoria 16, 20133Milano (Italy)

    1997-06-01

    A new beam dynamics regime of RF Photoinjectors is presented here, dealing with a violent bunch elongation under the action of longitudinal space charge forces. It is shown that such a blow-out expansion of the electron bunch can lead to highly linear behaviors of both the longitudinal and the transverse space charge field, a well known prerequisite to achieve minimum emittance dilution in photoinjectors. If operated in the ultra-short pancake-like bunch regime, such an effect can be very beneficial to the emittance correction mechanism, making it effective also for ultra-short pancake like bunches. The anticipated performances are presented: kA peak current beams can be generated directly out of the photoinjector (10 to 20 MeV exit energy) with rms normalized emittances below 1mm{center_dot}mrad. {copyright} {ital 1997 American Institute of Physics.}

  2. Pulsar Timing Arrays and Gravity Tests in the Radiative Regime

    CERN Document Server

    Lee, K J

    2014-01-01

    In this paper, we focus on testing gravity theories in the radiative regime using pulsar timing array observations. After reviewing current techniques to measure the dispersion and alternative polarization of gravitational waves, we extend the framework to the most general situations, where the combinations of a massive graviton and alternative polarization modes are considered. The atlas of the Hellings-Downs functions is completed by the new calculations for these dispersive alternative polarization modes. We find that each mode and corresponding graviton mass introduce characteristic features in the Hellings-Downs function. Thus, in principal, we can not only detect each polarization mode, measure the corresponding graviton mass, but also discriminate the different scenarios. In this way, we can test gravity theories in the radiative regime in a generalized fashion, and such method is a direct experiment, where one can address the gauge symmetry of the gravity theories in their linearised limits. Although ...

  3. FLOW REGIMES BELOW AERATORS FOR DISCHARGE TUNNELS

    Institute of Scientific and Technical Information of China (English)

    MA Fei; WU Jian-hua

    2012-01-01

    The flow regimes below an aerator influence directly the air entrainment and the cavitation damage control.Based on the theoretical considerations,the experiments of the aerator for a discharge tunnel were conducted,and the relationships between the flow regime and hydraulic and geometric parameters were investigated.The results showed that,there are two kinds of threshold values for the flow regime conversions.One is Fr1-2 standing for the conversion from the fully filled cavity to the partially filled cavity,and the other is Fr2-3 which shows the change from the partially filled cavity to the net air cavity.Two empirical expressions were obtained for the conversions of the flow regimes,which can be used in the designs of the aerators.

  4. US Forest Service LANDFIRE Historical Fire Regimes

    Data.gov (United States)

    US Forest Service, Department of Agriculture — Historical fire regimes, intervals, and vegetation conditions are mapped using the Vegetation Dynamics Development Tool (VDDT). These data support fire and landscape...

  5. Figure 1: Basal-Bolus Regime

    African Journals Online (AJOL)

    Siegal_D

    Breakfast. Lunch. Dinner. Bedtime. Plasma insulin concentrations over time with a twice daily insulin mix regime .... Hypoglycaemia. Frequency, severity, awareness, precipitants, driving, ... Post GDM, family members, IGT etc. EXAMINATION.

  6. Regimes of validity for balanced models

    Science.gov (United States)

    Gent, Peter R.; McWilliams, James C.

    1983-07-01

    Scaling analyses are presented which delineate the atmospheric and oceanic regimes of validity for the family of balanced models described in Gent and McWilliams (1983a). The analyses follow and extend the classical work of Charney (1948) and others. The analyses use three non-dimensional parameters which represent the flow scale relative to the Earth's radius, the dominance of turbulent or wave-like processes, and the dominant component of the potential vorticity. For each regime, the models that are accurate both at leading order and through at least one higher order of accuracy in the appropriate small parameter are then identified. In particular, it is found that members of the balanced family are the appropriate models of higher-order accuracy over a broad range of parameter regimes. Examples are also given of particular atmospheric and oceanic phenomena which are in the regimes of validity for the different balanced models.

  7. Exchange rate regimes and external financial stability

    Directory of Open Access Journals (Sweden)

    Stoica Ovidiu

    2016-01-01

    Full Text Available Financial stability within the framework of the global financial crisis has become a common topic for researchers and practitioners. In order to analyse the impact of exchange rate regimes on financial stability we use both the de jure and de facto exchange rate classifications. We apply the model to a 1999-2010 annual data sample for 135 countries and territories, grouped by the level of economic development. Our second focus is the investigation of the effects of the exchange rate regimes in three economic integration areas (member countries of the European Union 27, the Southern Common Market, and the Association of Southeast Asian Nations on financial stability. Our results generally support the central banks’ concerns that the flexibility of exchange rate regimes should be reduced in order to sustain financial stability; however, the findings are not robust when using alternative regime classifications.

  8. Prediction of regulatory elements

    DEFF Research Database (Denmark)

    Sandelin, Albin

    2008-01-01

    Finding the regulatory mechanisms responsible for gene expression remains one of the most important challenges for biomedical research. A major focus in cellular biology is to find functional transcription factor binding sites (TFBS) responsible for the regulation of a downstream gene. As wet-lab...

  9. Portfolio Selection with Jumps under Regime Switching

    Directory of Open Access Journals (Sweden)

    Lin Zhao

    2010-01-01

    Full Text Available We investigate a continuous-time version of the mean-variance portfolio selection model with jumps under regime switching. The portfolio selection is proposed and analyzed for a market consisting of one bank account and multiple stocks. The random regime switching is assumed to be independent of the underlying Brownian motion and jump processes. A Markov chain modulated diffusion formulation is employed to model the problem.

  10. Regime dependence of photo-darkening-induced modal degradation in high power fiber amplifier (Conference Presentation)

    Science.gov (United States)

    Boullet, Johan; Vincont, Cyril; Jolly, Alain; Pierre, Christophe

    2017-03-01

    Thermally induced transverse modal instabilities (TMI) have attracted these five years an intense research efforts of the entire fiber laser development community, as it represents the current most limiting effect of further power scaling of high power fiber laser. Anyway, since 2014, a few publications point out a new limiting thermal effect: fiber modal degradation (FMD). It is characterized by a power rollover and simultaneous increase of the cladding light at an average power far from the TMI threshold together with a degraded beam which does not exhibit temporal fluctuations, which is one of the main characteristic of TMI. We report here on the first systemic experimental study of FMD in a high power photonic crystal fiber. We put a particular emphasis on the dependence of its average power threshold on the regime of operation. We experimentally demonstrate that this dependence is intrinsically linked to regime-dependent PD-saturated losses, which are nearly three times higher in CW regime than in short pulse picosecond regime. We make the hypothesis that the existence of these different PD equilibrium states between CW regime and picosecond QCW pulsed regime is due to a partial photo-bleaching of color centers in picosecond regime thanks to a higher probability of multi-photon process induced photobleaching (PB) at high peak power. This hypothesis is corroborated by the demonstration of the reversibility of the FMD induced in CW regime by simply switching the seed CW 1064 nm light by a short pulse, picosecond oscillator.

  11. REGULATORY AGENCIES, CONSUMER AND ENVIROMENT

    Directory of Open Access Journals (Sweden)

    Giseli Valezi Raymundo

    2011-03-01

    Full Text Available The aim of this paper is to present the analysis on the insertion of the consumer in the current model of State in Brazil, considering the nowaday legal system. It is wished to be shown, moreover, the already existing reality on the theme, even if modest, so to in a way to question the responsibility of the consumer, according to its consuming habits and its inertia, takes in today’s technological society. To such proposal, the most effective research method, and, for this reason had been used in this paper, is the extensive bibliography research and legislation consultation. Through it, it had been found that the State model has changed over the past decades in order to delegate the execution of various activities of State ownership to private enterprise, in view of the existence of a minimal State and governor. In this sense, there were created the Regulatory Agencies, which are indirect public administration entities, with the ultimate objective of regulating and supervising the execution of those legal activities, performed by the private sector. The consumer, inserted in this reality, is the direct recipient of the action of the mentioned entities, questioning the legislative and sanction legitimacy of the regulatory entities as well as the possibility of judicial review on the merits of administrative actions of these entities and the applicability of the Brazilian Code of Defense of the Consumer (CDC to the execution of public services, a discipline that affects the administrative law rights. Notwithstanding the above analysis in context, all these social workers, consumers and regulatory agencies are immersed in changing habits, due to the optimization of actions, aimed at preserving the environment, the prospect of achieving sustainable development. Based on this perspective, the results brought by the survey showed that the application of the Brazilian Code of Defense of the Consumer in relations between consumers does not preclude

  12. Phylogeny based discovery of regulatory elements

    Directory of Open Access Journals (Sweden)

    Cohen Barak A

    2006-05-01

    Full Text Available Abstract Background Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites; however, most methods do not take advantage of an explicit model for the constrained evolution of functional DNA sequences. Results We developed a probabilistic framework that combines an HKY85 model, which assigns probabilities to different base substitutions between species, and weight matrix models of transcription factor binding sites, which describe the probabilities of observing particular nucleotides at specific positions in the binding site. The method incorporates the phylogenies of the species under consideration and takes into account the position specific variation of transcription factor binding sites. Using our framework we assessed the suitability of alignments of genomic sequences from commonly used species as substrates for comparative genomic approaches to regulatory motif finding. We then applied this technique to Saccharomyces cerevisiae and related species by examining all possible six base pair DNA sequences (hexamers and identifying sequences that are conserved in a significant number of promoters. By combining similar conserved hexamers we reconstructed known cis-regulatory motifs and made predictions of previously unidentified motifs. We tested one prediction experimentally, finding it to be a regulatory element involved in the transcriptional response to glucose. Conclusion The experimental validation of a regulatory element prediction missed by other large-scale motif finding studies demonstrates that our approach is a useful addition to the current suite of tools for finding regulatory motifs.

  13. Analysis of electrical circuits with variable load regime parameters projective geometry method

    CERN Document Server

    Penin, A

    2015-01-01

    This book introduces electric circuits with variable loads and voltage regulators. It allows to define invariant relationships for various parameters of regime and circuit sections and to prove the concepts characterizing these circuits. Generalized equivalent circuits are introduced. Projective geometry is used for the interpretation of changes of operating regime parameters. Expressions of normalized regime parameters and their changes are presented. Convenient formulas for the calculation of currents are given. Parallel voltage sources and the cascade connection of multi-port networks are d

  14. Bitcoin: a regulatory nightmare to a libertarian dream

    Directory of Open Access Journals (Sweden)

    Primavera De Filippi

    2014-05-01

    Full Text Available This article provides an overview of national policies and current discussions on the regulation of bitcoin in Europe and beyond. After presenting the potential threat that cryptocurrencies pose to governmental and financial institutions worldwide, it discusses the regulatory challenges and the difficulty for national regulators to come up with a sound regulatory framework, which the author believes explains the current (lack of regulatory responses in this field. The article concludes that regulation is needed, but that in order not to excessively stifle innovation in this nascent ecosystem, some of these challenges might better be addressed through self-regulation.

  15. Fiscal Policy and Welfare under Different Exchange Rate Regimes

    DEFF Research Database (Denmark)

    Østrup, Finn

    regime in whichthe monetary authority optimises preferences which include an employment targetand an inflation target. As government spending affects the representativeindividual's utility, the choice of exchange rate regime has an impact on welfare.Keywords: exchange rate regimes; fiscal policy...

  16. Derivation of the Fick's Law for the Lorentz Model in a low density regime

    OpenAIRE

    Basile, Giada; Nota, Alessia; Pezzotti, Federica; Pulvirenti, Mario

    2014-01-01

    We consider the Lorentz model in a slab with two mass reservoirs at the boundaries. We show that, in a low density regime, there exists a unique stationary solution for the microscopic dynamics which converges to the stationary solution of the heat equation, namely to the linear profile of the density. In the same regime the macroscopic current in the stationary state is given by the Fick's law, with the diffusion coefficient determined by the Green-Kubo formula.

  17. Derivation of the Fick's Law for the Lorentz Model in a Low Density Regime

    Science.gov (United States)

    Basile, G.; Nota, A.; Pezzotti, F.; Pulvirenti, M.

    2015-06-01

    We consider the Lorentz model in a slab with two mass reservoirs at the boundaries. We show that, in a low density regime, there exists a unique stationary solution for the microscopic dynamics, which converges to the stationary solution of the heat equation, namely to the linear profile of the density. In the same regime, the macroscopic current in the stationary state is given by the Fick's law, with the diffusion coefficient determined by the Green-Kubo formula.

  18. Regime Shift Identification of Runoff and Sediment Loads in the Yellow River Basin, China

    OpenAIRE

    Fei Wang; Guangju Zhao; Xingmin Mu; Peng Gao; Wenyi Sun

    2014-01-01

    Runoff and sediment loads have exhibited significant changes over the past six decades in the Yellow River Basin, China. The current study evaluates the changing trends and regime shifts in runoff and sediment loads at both the annual and monthly time scales. The associated spatial and temporal variations are analyzed by a sequential t-test analysis of the regime shifts (STARS) approach and the “breaks for additive seasonal and trend” (BFAST) model using hydrological data at eight stations f...

  19. Causas estruturais e consequências dos regimes internacionais: regimes como variáveis intervenientes

    OpenAIRE

    Stephen D. Krasner

    2012-01-01

    Os regimes internacionais são definidos como princípios, normas, regras e procedimentos de tomada de decisões ao redor dos quais as expectativas dos atores convergem em uma dada área-tema. Como ponto de partida, os regimes são conceituados como variáveis intervenientes, estando entre fatores causais básicos e os resultados e comportamentos relacionados. Há três visões a respeito da importância dos regimes: as orientações estruturais convencionais desvalorizam os regimes como sendo, na melhor ...

  20. Like or dislike : Intrapersonal regulatory fit affects the intensity of interpersonal evaluation

    NARCIS (Netherlands)

    Hamstra, Melvyn R. W.; Van Yperen, Nico W.; Wisse, Barbara; Sassenberg, Kai

    2013-01-01

    Regulatory fit is an experience of motivational force that makes individuals feel 'right'. Prior work has almost exclusively focused on how regulatory fit affects individuals' experience of tasks, activities, and products and has primarily focused on the bright side of regulatory fit. The current re

  1. Like or dislike : Intrapersonal regulatory fit affects the intensity of interpersonal evaluation

    NARCIS (Netherlands)

    Hamstra, Melvyn R. W.; Van Yperen, Nico W.; Wisse, Barbara; Sassenberg, Kai

    Regulatory fit is an experience of motivational force that makes individuals feel 'right'. Prior work has almost exclusively focused on how regulatory fit affects individuals' experience of tasks, activities, and products and has primarily focused on the bright side of regulatory fit. The current

  2. Like or dislike : Intrapersonal regulatory fit affects the intensity of interpersonal evaluation

    NARCIS (Netherlands)

    Hamstra, Melvyn R. W.; Van Yperen, Nico W.; Wisse, Barbara; Sassenberg, Kai

    2013-01-01

    Regulatory fit is an experience of motivational force that makes individuals feel 'right'. Prior work has almost exclusively focused on how regulatory fit affects individuals' experience of tasks, activities, and products and has primarily focused on the bright side of regulatory fit. The current re

  3. Nuclear Regulatory Commission information digest

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1990-03-01

    The Nuclear Regulatory Commission information digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the commission. This is an annual publication for the general use of the NRC Staff and is available to the public. The digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  4. Dispersion modeling in assessing air quality of industrial projects under Indian regulatory regime

    Directory of Open Access Journals (Sweden)

    Amitava Bandyopadhyay

    2010-01-01

    Full Text Available Environmental impact assessment (EIA studies conducted over the years as a part of obtaining environmental clearance in accordance with Indian regulation have been given significant attention towards carrying out Gaussian dispersion modeling for predicting the ground level concentration (GLC of pollutants, especially for SO2. Making any adhoc decision towards recommending flue gas desulfurization (FGD system in Indian fossil fuel combustion operations is not realistic considering the usage of fuel with low sulfur content. Thus a predictive modeling is imperative prior to making any conclusive decision. In the light of this finding, dispersion modeling has been accorded in Indian environmental regulations. This article aims at providing approaches to ascertain pollution potential for proposed power plant operation either alone or in presence of other industrial operations under different conditions. In order to assess the performance of the computational work four different cases were analyzed based on worst scenario. Results obtained through predictions were compared with National Ambient Air Quality Standards (NAAQS of India. One specific case found to overshoot the ambient air quality adversely in respect of SO2 and was therefore, suggested to install a FGD system with at least 80 % SO2 removal efficiency. With this recommendation, the cumulative prediction yielded a very conservative resultant value of 24 hourly maximum GLC of SO2 as against a value that exceeded well above the stipulated value without considering the FGD system. The computational algorithm developed can therefore, be gainfully utilized for the purpose of EIA analysis in Indian condition.

  5. Refinery effluent analysis methodologies for relevant parameters from EU-regulatory regimes

    Energy Technology Data Exchange (ETDEWEB)

    Westwood, D.; Ward, T. [Beta Technology Ltd, Heavens Walk, Doncaster, South Yorkshire DN4 5HZ (United Kingdom); Prescott, N.; Rippin, I. [Environment Agency, National Laboratory Service, PO Box 544 Rotherham S60 1BY (United Kingdom); Comber, M.; Den Haan, K.

    2013-08-15

    This report provides guidance to CONCAWE members on the analytical methods that might be used to monitor oil refinery effluents for those refinery-specific parameters covered by relevant European legislation and a comparison of the methods that are used today, as reported in the last Effluent Survey. A method assessment programme is presented whereby the performance of methods of analysis (used to monitor oil refinery effluents) can be compared and prioritised in order of their analytical performance capabilities. Methods for a specific parameter, which is clearly and unambiguously defined, are compared with each other and then prioritised in terms of their overall quality. The quality of these methods is based on an assessment of a combination of characteristic features, namely, precision, bias or recovery, limit of detection (where appropriate), indicative costs, and ease of use. Ranking scores for each feature are assigned to various ranges of each feature, and then added together to give an overall ranking value. The method exhibiting the lowest overall ranking value is deemed the most appropriate method for analysing that parameter. Within this report, several recommendations are made in terms of comparing results of analyses or their associated uses. Where data are to be compared for a particular parameter, then, all CONCAWE members involved in this comparison should agree common objectives, in advance. These include defining a common definition for the: (1) Parameter being analysed and compared; (2) Limit of detection, and how this concentration value should be calculated; (3) Limit of quantification, and how this concentration value should be calculated and how it is to be applied for selective reporting purposes; and (4) Uncertainty of measurement and how it should be calculated. It is further recommended that these involved members should agree on the range of values and ranking scores chosen to reflect the performance characteristic features used in the method assessment programme, or establish and agree alternative values. In addition, CONCAWE members should agree to provide details of the methods they use and the performance data obtained on their own specific effluents, so that appropriate and realistic method assessment comparisons can be undertaken. CONCAWE desires to collate this appropriate information relevant to their specific sector from its members in a way that the assessment programme can be regularly updated with new data, enabling methods to be compared in a way that is more directly applicable to the refinery sector.

  6. The unbundling regime for electricity utilities in the EU. A case of legislative and regulatory capture?

    Energy Technology Data Exchange (ETDEWEB)

    Van Koten, S.; Ortmann, A. [CERGE-EI, P.O. Box 882, Politickych veznu 7, 111 21 Praha 1 (Czech Republic)

    2008-11-15

    Theory and empirics suggest that by curbing competition, incumbent electricity companies which used to be, and here are referred to as, Vertically Integrated Utilities (VIUs), can increase their profitability through combined ownership of generation and transmission and/or distribution networks. Because curbing competition is generally believed to be welfare-reducing, EU law requires unbundling (separation) of the VIU networks. However, the EU allows its member states the choice between incomplete (legal) and complete (ownership) unbundling. There is tantalizing anecdotal evidence that VIUs have tried to influence this choice through questionable means of persuasion. Such means of persuasion should be more readily available in countries with a more corrupted political culture. This paper shows that among the old EU member states, countries which are perceived as more corrupt are indeed more likely to apply weaker forms of unbundling. Somewhat surprisingly, we do not obtain a similar finding for the EU member states that acceded in 2004. We provide a conjecture for this observation. (author)

  7. Various regimes of instability and formation of coastal eddies along the shelf bathymetry

    Science.gov (United States)

    Cimoli, Laura; Stegner, Alexandre; Roullet, Guillaume

    2016-04-01

    The impact of shelf slope on the stability of coastal currents and the nonlinear formation of coastal meanders and eddies are investigated by linear analysis and numerical simulations using an idealized channel configuration of the ROMS model. The impact of the shelf bathymetry leads to different regimes of instability of coastal currents that can both enhance or prevent the cross-shore transport. While keeping unchanged a coastal jet, we tested its unstable evolution for various depth and topographic slopes. Unlike standard linear stability analysis devoted to the very first stage of instability we focus on the non-linear end state, i.e. the formation of coastal eddies or meanders, to classify the various dynamical regimes. Two dimensionless numbers are used to quantify the parameter space of theses various regimes: the vertical aspect ratio gamma and the topographic parameter Tp, which is defined as the ratio of the topographic Rossby waves speed over the jet speed and is proportional to the shelf slope. We found four distinct regimes of instability, namely: standard baroclinic instability, horizontal shear instability, trapped coastal instability and quasi-stable jet. Our results show that Tp is the key parameter that controls the non-linear saturation of the coastal current, while gamma controls the transition from the standard baroclinic instability to the horizontal shear instability. Moreover, our analysis exhibit a new regime of formation of submeso-scale eddies. Contrary to the standard baroclinic instability regime, these eddies are trapped over the slope and never escape off-shore.

  8. Socioecological regime shifts in the setting of complex social interactions

    Science.gov (United States)

    Sugiarto, Hendrik Santoso; Chung, Ning Ning; Lai, Choy Heng; Chew, Lock Yue

    2015-06-01

    The coupling between social and ecological system has become more ubiquitous and predominant in the current era. The strong interaction between these systems can bring about regime shifts which in the extreme can lead to the collapse of social cooperation and the extinction of ecological resources. In this paper, we study the occurrence of such regime shifts in the context of a coupled social-ecological system where social cooperation is established by means of sanction that punishes local selfish act and promotes norms that prescribe nonexcessive resource extraction. In particular, we investigate the role of social networks on social-ecological regimes shift and the corresponding hysteresis effects caused by the local ostracism mechanism under different social and ecological parameters. Our results show that a lowering of network degree reduces the hysteresis effect and also alters the tipping point, which is duly verified by our numerical results and analytical estimation. Interestingly, the hysteresis effect is found to be stronger in scale-free network in comparison with random network even when both networks have the same average degree. These results provide deeper insights into the resilience of these systems, and can have important implications on the management of coupled social-ecological systems with complex social interactions.

  9. Hastening the regulatory process

    Energy Technology Data Exchange (ETDEWEB)

    Stringham, G. [Canadian Association of Petroleum Producers, Calgary, AB (Canada)

    2001-07-01

    The state of the Canadian oil industry was discussed during this power point presentation with particular emphasis on its production, exports, drilling, industry revenues and capital investment levels. The proposed projects in each of northern Alberta's oil sands deposits, the Athabasca, Peace River and Cold Lake were were announced, along with the inventory of major Alberta projects and the projection of oil sands capital investment. Since 1998, $9 billion has been invested and a further $33 billion has been announced for new or expanded oil sands projects. The year 2000 estimates for Canadian crude oil and natural gas production are 2.3 million barrels per day and 6.3 trillion cubic feet per year respectively. This represented a record year for production of both crude oil and natural gas. In 2000, more than 15,500 wells were drilled in Canada. A graph depicting Canadian crude oil supply forecasted a steady increase in supply from year 2000 to 2010. The Canadian Association of Petroleum Producers (CAPP) completed a review of the Alberta Energy and Utilities Board regulatory and enforcement processes. Both industry and government efforts are focusing on eliminating regulatory overlap and duplication. Some of the main areas of interest for exploration, drilling, production and pipeline facilities include the examination of regulatory processes for environmentally sensitive areas, rural municipalities with planning bylaws, aboriginal lands and additional fees. 8 figs.

  10. 移动医疗APP运行现状及其法律监管问题初探%Discussion on the Current Running Status of Mobile Medical APP and Relevant Legal Regulatory Issues

    Institute of Scientific and Technical Information of China (English)

    邓勇; 刘威; 李桐萱

    2015-01-01

    In recent years, the mobile medical market is increasingly becoming a trans-boundary focus. The operation of "medical + IT" mode has constructed a complete mobile medical industry chain. However, the development of emerging health industry represented by mobile medical APP (Application) is facing a lot of trouble. What's more, its benign operation also needs legal regulation. This paper ifrstly interpreted the formation, development and function of mobile medical APP, and then analyzed the current dilemma that mobile medical APP suffered from, ifnally put forward the concrete measures to solve the problems in running of the mobile medical APP.%近年来,移动医疗市场正日益成为跨界焦点,"医疗+IT"模式的运行,构建了一条完整的移动医疗产业链.然而,以移动医疗APP为代表的新兴医疗产业正面临诸多发展困境,其良性运行亦亟待法律监管.本文首先解读了移动医疗APP的产生、发展及功能,然后剖析了当前移动医疗APP遇到的种种困境,最后针对性地提出了破解移动医疗APP运行困境的具体对策.

  11. Baryons in the chiral regime

    Energy Technology Data Exchange (ETDEWEB)

    Knippschild, Bastian

    2012-03-05

    Quantum Chromodynamics (QCD) is the theory of strong interactions, one of the four fundamental forces in our Universe. It describes the interaction of gluons and quarks which build up hadrons like protons and neutrons. Most of the visible matter in our universe is made of protons and neutrons. Hence, we are interested in their fundamental properties like their masses, their distribution of charge and their shape. The only known theoretical, non-perturbative and ab initio method to investigate hadron properties at low energies is lattice Quantum Chromodynamics (lattice QCD). However, up-to-date simulations (especially for baryonic quantities) do not achieve the accuracy of experiments. In fact, current simulations do not even reproduce the experimental values for the form factors. The question arises wether these deviations can be explained by systematic effects in lattice QCD simulations. This thesis is about the computation of nucleon form factors and other hadronic quantities from lattice QCD. So called Wilson fermions are used and the u- and d-quarks are treated fully dynamically. The simulations were performed using gauge ensembles with a range of lattice spacings, volumes and pion masses. First of all, the lattice spacing was set to be able to make contact between the lattice results and their experimental complement and to be able to perform a continuum extrapolation. The light quark mass has been computed and found to be m{sub ud}{sup MS}(2 GeV)=3.03(17)(38) MeV. This value is in good agreement with values from experiments and other lattice determinations. Electro-magnetic and axial form factors of the nucleon have been calculated. From these form factors the nucleon radii and the coupling constants were computed. The different ensembles enabled us to investigate systematically the dependence of these quantities on the volume, the lattice spacing and the pion mass. Finally we perform a continuum extrapolation and chiral extrapolations to the physical point

  12. A Safety-Case Regime for Commercial Human Spaceflight

    Science.gov (United States)

    Sgobba, T.; Trujillo, M.

    2012-01-01

    Currently the commercial human spaceflight community seems to be embracing the obsolete design principles of "fly-fix-fly", and betting on public acceptance of risks comparable to those of the early times of aviation industry. The nascent space tourism industry maintains that early safety regulations (apart public safety) would kill industry and that such regulations could be developed only later when substantial operational experience is gained. Truly, most of current commercial aviation safety regulations are based on prescriptive requirements (i.e. explicitly required design solution for an implicit goal), which have been incrementally developed over more than a half century of mass transportation by air, and cannot be in general directly applied to innovative systems. However modern complex safety-critical systems cannot risk catastrophic failures while their operational experience is being accumulated, for such reason they are developed through the so called safety-case regime. ESA is currently drafting a safety standard for its future human rated transportation systems that is based on such regime. Such standard can be easily tailored with few modifications and applied to the development of a sub-orbital commercial space vehicle. In any case, because the safety-case regime makes extensive use of generically formulated requirements, the support of skilled safety engineers fully integrated into the design team is required since the very beginning. Furthermore the safety certification team needs also to be experienced in the review of safety-case based designs. Finally a quantitative safety target needs to be included and verified as the ultimate "prove of goodness" of system design.

  13. Making Promises Good: The Anti-Money Laundering Regime as a Multi-Purpose Tool for Governance

    Directory of Open Access Journals (Sweden)

    Stavros Katsios

    2016-01-01

    Full Text Available The creation of this international anti-money laundering regulatory regime is, contrary to itsneglect by the literature, important in two ways. First, it provides us with a second example -alongside the Basle Accord – with which we can examine how political barriers to regulatorycooperation and coordination might be overcome; without overstating the success of the antimoneylaundering regime the paper argues that a lot of the political circumstances that enabledcooperation and coordination to develop in this case can be applied in facing other economiccrime forms. The FATF case may help us to identify important political conditions that can fostercollective regulatory initiatives in the international financial area and especially in South EasternEurope. Additionally the anti-money laundering regime may be useful more directly in pursuingsome other regulatory and security goals of particular interest for the Balkan region. Specifically,the kinds of international cooperation and coordination that have been introduced to combatmoney laundering may help to strengthen international regulatory initiatives aimed at curbingcorruption, tax evasion and capital flight and fighting the threat deriving from internationalorganised crime and global terrorism.

  14. Regulatory overview of digital I and C system in Taiwan Lungmen Project

    Energy Technology Data Exchange (ETDEWEB)

    Chuang, C.F. [Department of Engineering and System Science, National Tsing Hua University, Taipei, Taiwan (China); Nuclear Regulatory Division, Atomic Energy Council, Taiwan (China)], E-mail: chuang@aec.gov.tw; Chou, H.P. [Department of Engineering and System Science, National Tsing Hua University, Taipei, Taiwan (China)], E-mail: hpc@mx.nthu.edu.tw; Chen, Y.B. [Nuclear Regulatory Division, Atomic Energy Council, Taiwan (China)], E-mail: ybchen@aec.gov.tw; Shiao, H. [Nuclear Regulatory Division, Atomic Energy Council, Taiwan (China)], E-mail: shiao@aec.gov.tw

    2008-05-15

    The Lungmen Nuclear Power Plant (LMNPP) is currently under construction in Taiwan, which consists of two Advanced Boiling Water Reactor (ABWR) units. The instrumentation and control (I and C) systems of the Lungmen NPS are based on the state-of-the-art modernized fully integrated digital design. The design and architecture of digital systems are inherently different from those of analog systems. We face challenges in areas where there is limited technical guidance and regulatory precedent. This paper presents regulatory overviews, regulatory requirements, current major regulatory issues, as well as the areas of regulatory concerns and the lessons learned on the digital I and C systems in the Lungmen Project.

  15. Regulatory Impact Analysis: a new tool for better regulation at ANVISA.

    Science.gov (United States)

    Alves, Flávia Neves Rocha; Peci, Alketa

    2011-08-01

    Regulatory Impact Analysis, which is recommended to regulatory departments, aims to improve regulatory quality by providing information about the costs and benefits of regulation as well as solutions to current issues to enhance the decision-making process. This article discusses the importance of Regulatory Impact Analysis in the context of the National Agency for Sanitary Surveillance performance as well as the agency's current phase of regulation improvement and strengthening. Also, the main definitions related to the regulatory field as well as some international case experiences are presented.

  16. INTERFACIAL AREA TRANSPORT AND REGIME TRANSITION IN COMBINATORIAL CHANNELS

    Energy Technology Data Exchange (ETDEWEB)

    Seugjin Kim

    2011-01-28

    . This study investigates the geometric effects of 90-degree vertical elbows and flow configurations in two-phase flow. The study shows that the elbows make a significant effect on the transport characteristics of two-phase flow, which includes the changes in interfacial structures, bubble interaction mechanisms and flow regime transition. The effect of the elbows is characterized for global and local two-phase flow parameters. The global two-phase flow parameters include two-phase pressure, interfacial structures and flow regime transition. In order to characterize the frictional pressure drop and minor loss across the vertical elbows, pressure measurements are obtained across the test section over a wide range of flow conditions in both single-phase and two-phase flow conditions. A two-phase pressure drop correlation analogous to Lockhart-Martinelli correlation is proposed to predict the minor loss across the elbows. A high speed camera is employed to perform extensive flow visualization studies across the elbows in vertical upward, horizontal and vertical downward sections and modified flow regime maps are proposed. It is found that modified flow regime maps immediately downstream of the vertical upward elbow deviate significantly from the conventional flow regime map. A qualitative assessment of the counter-current flow limitation characteristics specific to the current experimental facility is performed. A multi-sensor conductivity probe is used to measure local two-phase flow parameters such as: void fraction, bubble velocity, interfacial area concentration and bubble frequency. The local measurements are obtained for six different flow conditions at ten measurement locations along axial direction of the test section. Both the vertical-upward and vertical-downward elbows have a significant impact on bubble distribution, resulting in, a bimodal distribution along the horizontal radius of the tube cross-section and migration of bubbles towards the inside of the

  17. Conductance of a quantum wire in the Wigner crystal regime

    OpenAIRE

    Matveev, K. A.

    2003-01-01

    We study the effect of Coulomb interactions on the conductance of a single-mode quantum wire connecting two bulk leads. When the density of electrons in the wire is very low, they arrange in a finite-length Wigner crystal. In this regime the electron spins form an antiferromagnetic Heisenberg chain with exponentially small coupling J. An electric current in the wire perturbs the spin chain and gives rise to a temperature-dependent contribution of the spin subsystem to the resistance. At low t...

  18. Regimes of turbulence without an energy cascade

    CERN Document Server

    Barenghi, C F; Baggaley, A W

    2016-01-01

    Experiments and numerical simulations of turbulent $^4$He and $^3$He-B have established that, at hydrodynamic length scales larger than the average distance between quantum vortices, the energy spectrum obeys the same 5/3 Kolmogorov law which is observed in the homogeneous isotropic turbulence of ordinary fluids. The importance of the 5/3 law is that it points to the existence of a Richardson energy cascade from large eddies to small eddies. However, there is also evidence of quantum turbulent regimes without Kolmogorov scaling. This raises the important questions of why, in such regimes, the Kolmogorov spectrum fails to form, what is the physical nature of turbulence without energy cascade, and whether hydrodynamical models can account for the unusual behaviour of turbulent superfluid helium. In this work we describe simple physical mechanisms which prevent the formation of Kolmogorov scaling in the thermal counterflow, and analyze the conditions necessary for emergence of quasiclassical regime in quantum tu...

  19. Interpreting MAD within multiple accretion regimes

    CERN Document Server

    Mocz, Philip

    2014-01-01

    General relativistic magnetohydrodynamic (GRMHD) simulations of accreting black holes in the radiatively inefficient regime show that systems with sufficient magnetic poloidal flux become magnetically arrested disc (MAD) systems, with a well-defined relationship between the magnetic flux and the mass accretion rate. Recently, Zamaninasab (2014) report that the jet magnetic flux and accretion disc luminosity are tightly correlated over 7 orders of magnitude for a sample of 76 radio-loud active galaxies, concluding that the data are explained by the MAD mode of accretion. Their analysis assumes radiatively efficient accretion, and their sample consists primarily of radiatively efficient sources, while GRMHD simulations of MAD thus far have been carried out in the radiatively inefficient regime. We propose a model to interpret MAD systems in the context of multiple accretion regimes, and apply it to the sample in Zamaninasab (2014), along with additional radiatively inefficient sources from archival data. We sho...

  20. Causas estruturais e consequências dos regimes internacionais: regimes como variáveis intervenientes

    Directory of Open Access Journals (Sweden)

    Stephen D. Krasner

    2012-06-01

    Full Text Available Os regimes internacionais são definidos como princípios, normas, regras e procedimentos de tomada de decisões ao redor dos quais as expectativas dos atores convergem em uma dada área-tema. Como ponto de partida, os regimes são conceituados como variáveis intervenientes, estando entre fatores causais básicos e os resultados e comportamentos relacionados. Há três visões a respeito da importância dos regimes: as orientações estruturais convencionais desvalorizam os regimes como sendo, na melhor das hipóteses, ineficazes; as orientações grocianas vêem os regimes como componentes íntimos do sistema internacional; as perspectivas estruturalistas modificadas vêem os regimes como significativos somente em certas condições restritas. Para os argumentos grociano e estruturalista modificado - que concordam com a visão de que os regimes podem influenciar resultados e comportamentos - , o desenvolvimento de regimes é visto como uma função de cinco variáveis causais básicas: auto-interesse egoísta; poder político; normas e princípios difusos; usos e costumes; conhecimento.

  1. Early detection of ecosystem regime shifts

    DEFF Research Database (Denmark)

    Lindegren, Martin; Dakos, Vasilis; Groeger, Joachim P.;

    2012-01-01

    methods may have limited utility in ecosystem-based management as they show no or weak potential for early-warning. We therefore propose a multiple method approach for early detection of ecosystem regime shifts in monitoring data that may be useful in informing timely management actions in the face......Critical transitions between alternative stable states have been shown to occur across an array of complex systems. While our ability to identify abrupt regime shifts in natural ecosystems has improved, detection of potential early-warning signals previous to such shifts is still very limited...

  2. Bank Liquidity and Exchange Rate Regimes

    OpenAIRE

    Bunda, Irina; Desquilbet, Jean-Baptiste

    2003-01-01

    International audience; Combining panel data on bank liquidity at the individual level and data on their macroeconomic environment, for a sample of commercial banks in emerging countries between 1995 and 2000, we show that their exists a “bank liquidity smile across exchange rate regimes”. In extreme regimes at both ends of the line, i.e. for pure floating exchange rate regimes at one end and currency boards and dollarized economies at the other end, bank assets are more liquid than in interm...

  3. Markovian quantum master equation beyond adiabatic regime

    Science.gov (United States)

    Yamaguchi, Makoto; Yuge, Tatsuro; Ogawa, Tetsuo

    2017-01-01

    By introducing a temporal change time scale τA(t ) for the time-dependent system Hamiltonian, a general formulation of the Markovian quantum master equation is given to go well beyond the adiabatic regime. In appropriate situations, the framework is well justified even if τA(t ) is faster than the decay time scale of the bath correlation function. An application to the dissipative Landau-Zener model demonstrates this general result. The findings are applicable to a wide range of fields, providing a basis for quantum control beyond the adiabatic regime.

  4. WELFARE REGIMES IN LATIN AMERICA AND CARIBBEAN

    Directory of Open Access Journals (Sweden)

    Melisa Campana-Alabarce

    2015-06-01

    Full Text Available This article provides a characterization of Latin American and Caribbean Welfare regimes in historiographical perspective. Firstly, it makes a review of the emergence conditions of Welfare States in Western Europe and its core features, with particular emphasis on its role as a method to regulate inequalities in industrial capitalism. Dialoguing with it, then stops in the specific configurations that welfare regimes have taken in Latin America during the course of the twentieth century. Finally, it provides a map of its contemporary features and the major challenges that the States of the region face in his capacity as right guarantors for the future.

  5. Light focusing in the Anderson Regime

    CERN Document Server

    Leonetti, Marco; Mafi, Arash; Conti, Claudio

    2014-01-01

    Anderson localization is a regime in which diffusion is inhibited and waves (also electromagnetic waves) get localized. Here we exploit adaptive optics to achieve focusing in disordered optical fibers in the Anderson regime. By wavefront shaping and optimization, we observe the generation of a propagation invariant beam, where light is trapped transversally by disorder, and show that Anderson localizations can be also excited by extended speckled beams. We demonstrate that disordered fibers allow a more efficient focusing action with respect to standard fibers in a way independent of their length, because of the propagation invariant features and cooperative action of transverse localizations.

  6. Convective Regimes in Crystallizing Basaltic Magma Chambers

    Science.gov (United States)

    Gilbert, A. J.; Neufeld, J. A.; Holness, M. B.

    2015-12-01

    Cooling through the chamber walls drives crystallisation in crustal magma chambers, resulting in a cumulate pile on the floor and mushy regions at the walls and roof. The liquid in many magma chambers, either the bulk magma or the interstitial liquid in the mushy regions, may convect, driven either thermally, due to cooling, or compositionally, due to fractional crystallization. We have constructed a regime diagram of the possible convective modes in a system containing a basal mushy layer. These modes depend on the large-scale buoyancy forcing characterised by a global Rayleigh number and the proportion of the chamber height constituting the basal mushy region. We have tested this regime diagram using an analogue experimental system composed of a fluid layer overlying a pile of almost neutrally buoyant inert particles. Convection in this system is driven thermally, simulating magma convection above and within a porous cumulate pile. We observe a range of possible convective regimes, enabling us to produce a regime diagram. In addition to modes characterised by convection of the bulk and interstitial fluid, we also observe a series of regimes where the crystal pile is mobilised by fluid motions. These regimes feature saltation and scouring of the crystal pile by convection in the bulk fluid at moderate Rayleigh numbers, and large crystal-rich fountains at high Rayleigh numbers. For even larger Rayleigh numbers the entire crystal pile is mobilised in what we call the snowglobe regime. The observed mobilisation regimes may be applicable to basaltic magma chambers. Plagioclase in basal cumulates crystallised from a dense magma may be a result of crystal mobilisation from a plagioclase-rich roof mush. Compositional convection within such a mush could result in disaggregation, enabling the buoyant plagioclase to be entrained in relatively dense descending liquid plumes and brought to the floor. The phenocryst load in porphyritic lavas is often interpreted as a

  7. The oil tax regime of Azerbaijan

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Gerard

    1998-07-01

    Azerbaijan has a long history in the oil business and a chance of a spectacular future. To understand why the oil tax regime evolved into its present form and how it is likely to develop, it is necessary to know something of the country's history and the commercial environment. Consequently the presentation begins by discussing these items. It then outlines the Production Sharing Agreement regime in Azerbaijan and then deals with the Kazakh and Georgian Tax Codes, as these are likely to be the basis of a new general tax law in Azerbaijan from 1999. The presentation includes comments on the New Draft Tax Code of 1998.

  8. A Policy Framework for Investment: An International Tool for Improving the Global Investment Regime

    Directory of Open Access Journals (Sweden)

    Andrey Sakharov

    2016-12-01

    Full Text Available International investment is one of the key drivers of economic growth in today’s world economy. Thus, creating favourable investment conditions is imperative for any state willing to maintain its competitiveness in attracting international investment capital required for sustainable economic growth. In this regard, the harmonization of investment and regulatory environments is one of the pressing issues facing many countries around the world. Addressing this issue is a collective task to be undertaken by leading economies, international organizations and informal global governance institutions, such as the Group of 20 (G20 or BRICS group of Brazil, Russia, India, China and South Africa. The contribution of the Organisation for Economic Co-operation and Development (OECD to harmonizing international investment regimes is significant and includes such documents as the OECD Declaration on International Investment and Multinational Enterprises, the Code of Liberalisation of Capital Movements, the Code of Liberalisation of Current Invisible Operations, G20/OECD High-Level Principles of Long-Term Investment Financing, and the Policy Framework for Investment (PFI. The PFI has become the most comprehensive and exhaustive compendium of investment policy best practices. This article analyzes the evolution of the PFI and the negotiation processes behind it to compare its content with analogous international documents dealing with investment policy and regulation across all 12 issue areas covered by the PFI, as well as to assess the international business community’s corresponding positions and contributions. It also addresses the OECD-G20 cooperation in formulating the future agenda for investment policy among the leading economies. The selected approach allows for a determination of the PFI’s role in shaping the potential set of universal investment policy principles and concrete rules.

  9. Codes and standards and other guidance cited in regulatory documents

    Energy Technology Data Exchange (ETDEWEB)

    Nickolaus, J.R.; Bohlander, K.L.

    1996-08-01

    As part of the U.S. Nuclear Regulatory Commission (NRC) Standard Review Plan Update and Development Program (SRP-UDP), Pacific Northwest National Laboratory developed a listing of industry consensus codes and standards and other government and industry guidance referred to in regulatory documents. The SRP-UDP has been completed and the SRP-Maintenance Program (SRP-MP) is now maintaining this listing. Besides updating previous information, Revision 3 adds approximately 80 citations. This listing identifies the version of the code or standard cited in the regulatory document, the regulatory document, and the current version of the code or standard. It also provides a summary characterization of the nature of the citation. This listing was developed from electronic searches of the Code of Federal Regulations and the NRC`s Bulletins, Information Notices, Circulars, Enforcement Manual, Generic Letters, Inspection Manual, Policy Statements, Regulatory Guides, Standard Technical Specifications and the Standard Review Plan (NUREG-0800).

  10. A feasibility study on regulatory analysis in the nuclear regulatory decision making process in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Lee, K. J.; Lee, B. W.; Lee, D. K.; Lim, C. Y.; Choi, Y. S.; Kim, K. K. [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1996-12-15

    Nuclear safety regulation has different implications from economic regulation. In recent survey, it was found that Korea people want more regulatory effort than current one. This indicates that scientific method is necessary to improve the efficiency of regulation with limited resources of regulators. The main reason to conduct the regulatory analysis like cost-benefit analysis is obtaining the rationality of regulation to be implemented and persuading the licensees to comply under the quantified condition. That is, the ultimate goal is to verify the necessity and justice of regulation and to achieve the safety goal with minimum impacts. Guidelines and procedures developed in this study should help regulators to reach that goal.

  11. Adélie penguin foraging location predicted by tidal regime switching.

    Science.gov (United States)

    Oliver, Matthew J; Irwin, Andrew; Moline, Mark A; Fraser, William; Patterson, Donna; Schofield, Oscar; Kohut, Josh

    2013-01-01

    Penguin foraging and breeding success depend on broad-scale environmental and local-scale hydrographic features of their habitat. We investigated the effect of local tidal currents on a population of Adélie penguins on Humble Is., Antarctica. We used satellite-tagged penguins, an autonomous underwater vehicle, and historical tidal records to model of penguin foraging locations over ten seasons. The bearing of tidal currents did not oscillate daily, but rather between diurnal and semidiurnal tidal regimes. Adélie penguins foraging locations changed in response to tidal regime switching, and not to daily tidal patterns. The hydrography and foraging patterns of Adélie penguins during these switching tidal regimes suggest that they are responding to changing prey availability, as they are concentrated and dispersed in nearby Palmer Deep by variable tidal forcing on weekly timescales, providing a link between local currents and the ecology of this predator.

  12. Methodology Development of a Gas-Liquid Dynamic Flow Regime Transition Model

    Science.gov (United States)

    Doup, Benjamin Casey

    Current reactor safety analysis codes, such as RELAP5, TRACE, and CATHARE, use flow regime maps or flow regime transition criteria that were developed for static fully-developed two-phase flows to choose interfacial transfer models that are necessary to solve the two-fluid model. The flow regime is therefore difficult to identify near the flow regime transitions, in developing two-phase flows, and in transient two-phase flows. Interfacial area transport equations were developed to more accurately predict the dynamic nature of two-phase flows. However, other model coefficients are still flow regime dependent. Therefore, an accurate prediction of the flow regime is still important. In the current work, the methodology for the development of a dynamic flow regime transition model that uses the void fraction and interfacial area concentration obtained by solving three-field the two-fluid model and two-group interfacial area transport equation is investigated. To develop this model, detailed local experimental data are obtained, the two-group interfacial area transport equations are revised, and a dynamic flow regime transition model is evaluated using a computational fluid dynamics model. Local experimental data is acquired for 63 different flow conditions in bubbly, cap-bubbly, slug, and churn-turbulent flow regimes. The measured parameters are the group-1 and group-2 bubble number frequency, void fraction, interfacial area concentration, and interfacial bubble velocities. The measurements are benchmarked by comparing the prediction of the superficial gas velocities, determined using the local measurements with those determined from volumetric flow rate measurements and the agreement is generally within +/-20%. The repeatability four-sensor probe construction process is within +/-10%. The repeatability of the measurement process is within +/-7%. The symmetry of the test section is examined and the average agreement is within +/-5.3% at z/D = 10 and +/-3.4% at z/D = 32

  13. In Search of the Chiral Regime

    CERN Document Server

    Beane, S R

    2004-01-01

    A critical appraisal is given of a recent analysis of the quark-mass and finite-size dependence of unquenched lattice QCD data for the nucleon mass. We use this forum to estimate the boundary of the chiral regime for nucleon properties.

  14. Developmental Regimes in Africa synthesis report

    NARCIS (Netherlands)

    Booth, D.; Dietz, A.J.; Golooba-Mutebi, F.; Fuady, A.H.; Henley, D.; Kelsall, T.; Leliveld, A.H.M.; Donge, van J.K.

    2015-01-01

    Many African countries have experienced sustained economic growth, but few have achieved the type of structural change, driven by rising productivity, that has transformed mass living standards in parts of Asia. In the Developmental Regimes in Africa Synthesis Report, editor David Booth examines how

  15. Regimes of flow past a vortex generator

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Okulov, V.L.; Naumov, I.V.

    2012-01-01

    A complete parametric investigation of the development of multi-vortex regimes in a wake past simple vortex generator has been carried out. It is established that the vortex structure in the wake is much more complicated than a simple monopole tip vortex. The vortices were studied by stereoscopic...

  16. Developmental Regimes in Africa synthesis report

    NARCIS (Netherlands)

    Booth, D.; Dietz, A.J.; Golooba-Mutebi, F.; Fuady, A.H.; Henley, D.; Kelsall, T.; Leliveld, A.H.M.; Donge, van J.K.

    2015-01-01

    Many African countries have experienced sustained economic growth, but few have achieved the type of structural change, driven by rising productivity, that has transformed mass living standards in parts of Asia. In the Developmental Regimes in Africa Synthesis Report, editor David Booth examines how

  17. Regime Change and the Role of Airpower

    Science.gov (United States)

    2006-08-01

    that connects the target sets with anticipated actions that lead to defeat of the regime. The theory’s mechanism relies on collective action theory as...collective action theory and Ted Gurr’s deprived actor theory to offer a theory of collective dissent. 7. Bueno de Mesquita et al., “Policy Failure

  18. A Global Classification of Contemporary Fire Regimes

    Science.gov (United States)

    Norman, S. P.; Kumar, J.; Hargrove, W. W.; Hoffman, F. M.

    2014-12-01

    Fire regimes provide a sensitive indicator of changes in climate and human use as the concept includes fire extent, season, frequency, and intensity. Fires that occur outside the distribution of one or more aspects of a fire regime may affect ecosystem resilience. However, global scale data related to these varied aspects of fire regimes are highly inconsistent due to incomplete or inconsistent reporting. In this study, we derive a globally applicable approach to characterizing similar fire regimes using long geophysical time series, namely MODIS hotspots since 2000. K-means non-hierarchical clustering was used to generate empirically based groups that minimized within-cluster variability. Satellite-based fire detections are known to have shortcomings, including under-detection from obscuring smoke, clouds or dense canopy cover and rapid spread rates, as often occurs with flashy fuels or during extreme weather. Such regions are free from preconceptions, and the empirical, data-mining approach used on this relatively uniform data source allows the region structures to emerge from the data themselves. Comparing such an empirical classification to expectations from climate, phenology, land use or development-based models can help us interpret the similarities and differences among places and how they provide different indicators of changes of concern. Classifications can help identify where large infrequent mega-fires are likely to occur ahead of time such as in the boreal forest and portions of the Interior US West, and where fire reports are incomplete such as in less industrial countries.

  19. Can Old Regimes Handle New Wars?

    DEFF Research Database (Denmark)

    Henningsen, Troels

    2017-01-01

    Research on New Wars argues that since the 1980s states and regimes have become more vulnerable to violence from non-state actors. Two developments in the Sahel region support the New Wars thesis: an increase in Islamist radicalization and new access to the global black market, both of which stre...

  20. The Forex Regime and EMU Expansion

    NARCIS (Netherlands)

    P.W. van Foreest; C.G. de Vries (Casper)

    2002-01-01

    textabstractThis paper provides empirical evidence that, irrespective of the foreign exchange rate regime, countries with high monetary volatility have lower relative output growth rates. It is argued that due to the forward looking nature of the foreign exchange market, exchange rate stability

  1. An emissions trading regime for Canada

    Energy Technology Data Exchange (ETDEWEB)

    Smith, S.L. [National Round Table on the Environment and the Economy, Ottawa, ON (Canada)

    2001-07-01

    In 1998, over twelve papers were published on emissions trading regimes in Canada by the National Round Table on the Environment and the Economy (NRTEE), a federal government agency whose members represent stakeholders as varied as business, environmental groups, academics, aboriginal groups and others. One of the recommendations that emerged was for the computer modelling of the possibilities that had been identified for a domestic trading regime in Canada for greenhouse gases. It is unclear whether the modelling was ever performed as the file was taken over by the Finance Department under the umbrella of a special emission trading table that examined Canada's commitment under the Kyoto Protocol. The author examined questions pertaining to whether a domestic trading regime is essential, and what its characteristics should be in case it was deemed essential or advisable to have one. The upstream versus downstream application was looked at, as well as grand-fathering versus auction. Provincial issues were then addressed, followed by meshing with a credit system. International systems were reviewed. Early action was discussed, whereby an emitter seeks credit for action taken toward reductions since the original reference year of 1990. The case of emitters having bought or sold permits since the original reference years will also want those trades recognized under a trading regime. The author indicated that it seems probable that an emission trading system will eventually be implemented and that a debate on the issue should be initiated early.

  2. The Forex Regime and EMU Expansion

    NARCIS (Netherlands)

    P.W. van Foreest; C.G. de Vries (Casper)

    2002-01-01

    textabstractThis paper provides empirical evidence that, irrespective of the foreign exchange rate regime, countries with high monetary volatility have lower relative output growth rates. It is argued that due to the forward looking nature of the foreign exchange market, exchange rate stability hing

  3. Optimal dividend distribution under Markov regime switching

    NARCIS (Netherlands)

    Jiang, Z.; Pistorius, M.

    2012-01-01

    We investigate the problem of optimal dividend distribution for a company in the presence of regime shifts. We consider a company whose cumulative net revenues evolve as a Brownian motion with positive drift that is modulated by a finite state Markov chain, and model the discount rate as a determini

  4. Proliferation Control Regimes: Background and Status

    Science.gov (United States)

    2012-10-25

    1984 OPCW U.N. Conference on Disarmament EAA, 1979 AECA, 1976 Biological Weapons Anti- Terrorism Act Chem- Bio Weapons Control Warfare...Deauville, France. They reaffirmed the goals set out at the 2010 Summit for future Global Partnership activities: nuclear and radiological security, bio ... herbicides and riot control agents. Proliferation Control Regimes: Background and Status Congressional Research Service 44 Author Contact

  5. Scaling Fire Regimes in Space and Time.

    Science.gov (United States)

    Falk, D. A.

    2004-12-01

    Spatial and temporal variability are important properties of the forest fire regimes of coniferous forests of southwestern North America. We use a variety of analytical techniques to examine scaling in a surface fire regime in the Jemez Mountains of northern New Mexico, USA, based on an original data set collected from Monument Canyon Research Natural Area (MCN). Spatio-temporal scale dependence in the fire regime can be analyzed quantitatively using statistical descriptors of the fire regime, such as fire frequency and mean fire interval. We describe a theory of the event-area (EA) relationship, an extension of the species-area relationship for events distributed in space and time; the interval-area (IA) relationship, is a related form for fire intervals. We use the EA and IA to demonstrate scale dependence in the MCN fire regime. The slope and intercept of these functions are influenced by fire size, frequency, and spatial distribution, and thus are potentially useful metrics of spatio-temporal synchrony of events in the paleofire record. Second, we outline a theory of fire interval probability, working from first principles in fire ecology and statistics. Fires are conditional events resulting from the interaction of multiple contingent factors that must be satisfied for an event to occur. Outcomes of this kind represent a multiplicative process for which a lognormal model is the limiting distribution. We examine the application of this framework to two probability models, the Weibull and lognormal distributions, which can be used to characterize the distribution of fire intervals over time. Lastly, we present a general model for the collector's curve, with application to the theory and effects of sample size in fire history. Sources of uncertainty in fire history can be partitioned into an error typology; analytical methods used in fire history (particularly the formation of composite fire records) are designed to minimize certain types of error in inference

  6. Politically Induced Regulatory Risk and Independent Regulatory Agencies

    OpenAIRE

    Strausz, Roland

    2015-01-01

    Uncertainty in election outcomes generates politically induced regulatory risk. Political parties' risk attitudes towards such risk depend on a fluctuation effect that hurts both parties and an output--expansion effect that benefits at least one party. Notwithstanding the parties' risk attitudes, political parties have incentives to negotiate away all regulatory risk by pre-electoral bargaining. Efficient pre-electoral bargaining outcomes fully eliminate politically induced regulatory risk. P...

  7. Regulatory Review Committee update

    Energy Technology Data Exchange (ETDEWEB)

    Steele, T. [Polishuk, Camman and Steele, London ON (Canada)

    2001-07-01

    The Committee's objectives, current membership and current issues are reviewed. Each current issue, notably the consultation process with the Ministry of Natural Resources, appeal of Ministry actions, orphan wells/security deposits, oilfield fluid disposal and labour code practices review are discussed in some detail. Dissatisfaction with the current appeals process to the Ministry is highlighted, along with a search for an all encompassing solution. The orphan well problem also received considerable attention, with similar demands for a comprehensive solution.

  8. Regulatory Challenges for Cartilage Repair Technologies.

    Science.gov (United States)

    McGowan, Kevin B; Stiegman, Glenn

    2013-01-01

    In the United States, few Food and Drug Administration (FDA)-approved options exist for the treatment of focal cartilage and osteochondral lesions. Developers of products for cartilage repair face many challenges to obtain marketing approval from the FDA. The objective of this review is to discuss the necessary steps for FDA application and approval for a new cartilage repair product. FDA Guidance Documents, FDA Panel Meetings, scientific organization recommendations, and clinicaltrials.gov were reviewed to demonstrate the current thinking of FDA and the scientific community on the regulatory process for cartilage repair therapies. Cartilage repair therapies can receive market approval from FDA as medical devices, drugs, or biologics, and the specific classification of product can affect the nonclinical, clinical, and regulatory strategy to bring the product to market. Recent FDA guidance gives an outline of the required elements to bring a cartilage repair product to market, although these standards are often very general. As a result, companies have to carefully craft their study patient population, comparator group, and clinical endpoint to best showcase their product's attributes. In addition, regulatory strategy and manufacturing process validation need to be considered early in the clinical study process to allow for timely product approval following the completion of clinical study. Although the path to regulatory approval for a cartilage repair therapy is challenging and time-consuming, proper clinical trial planning and attention to the details can eventually save companies time and money by bringing a product to the market in the most expeditious process possible.

  9. DYNAMIC MODELING STRATEGY FOR FLOW REGIME TRANSITION IN GAS-LIQUID TWO-PHASE FLOWS

    Energy Technology Data Exchange (ETDEWEB)

    X. Wang; X. Sun; H. Zhao

    2011-09-01

    In modeling gas-liquid two-phase flows, the concept of flow regime has been used to characterize the global interfacial structure of the flows. Nearly all constitutive relations that provide closures to the interfacial transfers in two-phase flow models, such as the two-fluid model, are often flow regime dependent. Currently, the determination of the flow regimes is primarily based on flow regime maps or transition criteria, which are developed for steady-state, fully-developed flows and widely applied in nuclear reactor system safety analysis codes, such as RELAP5. As two-phase flows are observed to be dynamic in nature (fully-developed two-phase flows generally do not exist in real applications), it is of importance to model the flow regime transition dynamically for more accurate predictions of two-phase flows. The present work aims to develop a dynamic modeling strategy for determining flow regimes in gas-liquid two-phase flows through the introduction of interfacial area transport equations (IATEs) within the framework of a two-fluid model. The IATE is a transport equation that models the interfacial area concentration by considering the creation and destruction of the interfacial area, such as the fluid particle (bubble or liquid droplet) disintegration, boiling and evaporation; and fluid particle coalescence and condensation, respectively. For the flow regimes beyond bubbly flows, a two-group IATE has been proposed, in which bubbles are divided into two groups based on their size and shape (which are correlated), namely small bubbles and large bubbles. A preliminary approach to dynamically identifying the flow regimes is provided, in which discriminators are based on the predicted information, such as the void fraction and interfacial area concentration of small bubble and large bubble groups. This method is expected to be applied to computer codes to improve their predictive capabilities of gas-liquid two-phase flows, in particular for the applications in

  10. Hydrological regime modifications induced by climate change in Mediterranean area

    Science.gov (United States)

    Pumo, Dario; Caracciolo, Domenico; Viola, Francesco; Valerio Noto, Leonardo

    2015-04-01

    The knowledge of river flow regimes has a capital importance for a variety of practical applications, in water resource management, including optimal and sustainable use. Hydrological regime is highly dependent on climatic factors, among which the most important is surely the precipitation, in terms of frequency, seasonal distribution and intensity of rainfall events. The streamflow frequency regime of river basins are often summarized by flow duration curves (FDCs), that offer a simple and comprehensive graphical view of the overall historical variability associated with streamflow, and characterize the ability of the basin to provide flows of various magnitudes. Climate change is likely to lead shifts in the hydrological regime, and, consequently, in the FDCs. Staring from this premise, the primary objective of the present study is to explore the effects of potential climate changes on the hydrological regime of some small Mediterranean basins. To this aim it is here used a recent hydrological model, the ModABa model (MODel for Annual flow duration curves assessment in ephemeral small BAsins), for the probabilistic characterization of the daily streamflows in small catchments. The model has been calibrated and successively validated in a unique small catchment, where it has shown a satisfactory accuracy in reproducing the empirical FDC starting from easily derivable parameters arising from basic ecohydrological knowledge of the basin and commonly available climatic data such as daily precipitation and temperatures. Thus, this work also represents a first attempt to apply the ModABa to basins different from that used for its preliminary design in order to testing its generality. Different case studies are selected within the Sicily region; the model is first calibrated at the sites and then forced by future climatic scenarios, highlighting the principal differences emerging from the current scenario and future FDCs. The future climate scenarios are generated using

  11. Clinical research: regulatory issues.

    Science.gov (United States)

    Wermeling, D P

    1999-02-01

    The regulatory issues faced by institutions performing clinical research are described. Many institutions do not have on staff an expert who understands the regulatory issues involved in managing investigational new drug research and who knows the institution's obligations under the federal rules. Because pharmacists understand the FDA regulations that apply to the management of drugs in clinical research, institutions are asking pharmacists to expand their role and manage clinical research offices. Many authorities govern various aspects of investigational drug research. FDA has published regulations for good clinical practice (GCP), and the International Conference on Harmonisation is developing an international standard for the proper management of clinical trials. The guidelines published by the Joint Commission on Accreditation of Healthcare Organizations aim to protect patients who are in the institution to receive health care and also participate in clinical trials. The Social Security Administration Acts specifically state that only items and services that are reasonable and necessary for the diagnosis and treatment of injury or disease can be billed to the government; research-related billings are excluded from coverage. Proper management of drug research is crucial to the success of a research program that is integrated with patient care.

  12. The Determinants of Exchange Rate Regimes in Emerging Market Economies

    OpenAIRE

    Mehmet Guclu

    2008-01-01

    The choice of exchange rate regime has become one of the most important issues one more time in many economies after the financial crises in recent years. In the wake of the financial crises, many countries, especially emerging market economies, opted for floating exchange rate regimes by forsaking the pegged regimes. Consequently, an old debate on the choice and determinants of exchange rate regimes has been triggered. Economists have started to debate what appropriate exchange rate regime f...

  13. Thermoelectric efficiency of nanoscale devices in the linear regime

    Science.gov (United States)

    Bevilacqua, G.; Grosso, G.; Menichetti, G.; Pastori Parravicini, G.

    2016-12-01

    We study quantum transport through two-terminal nanoscale devices in contact with two particle reservoirs at different temperatures and chemical potentials. We discuss the general expressions controlling the electric charge current, heat currents, and the efficiency of energy transmutation in steady conditions in the linear regime. With focus in the parameter domain where the electron system acts as a power generator, we elaborate workable expressions for optimal efficiency and thermoelectric parameters of nanoscale devices. The general concepts are set at work in the paradigmatic cases of Lorentzian resonances and antiresonances, and the encompassing Fano transmission function: the treatments are fully analytic, in terms of the trigamma functions and Bernoulli numbers. From the general curves here reported describing transport through the above model transmission functions, useful guidelines for optimal efficiency and thermopower can be inferred for engineering nanoscale devices in energy regions where they show similar transmission functions.

  14. Challenges in orphan drug development and regulatory policy in China

    OpenAIRE

    Cheng, Alice; Xie, Zhi

    2017-01-01

    While regulatory policy is well defined for orphan drug development in the United States and Europe, rare disease policy in China is still evolving. Many Chinese patients currently pay out of pocket for international treatments that are not yet approved in China. The lack of a clear definition and therefore regulatory approval process for rare diseases has, until now, de-incentivized pharmaceutical companies to pursue rare disease drug development in China. In turn, many grassroots movements ...

  15. Beyond the Crisis: Financial Regulatory Reform in Emerging Asia

    OpenAIRE

    Lee, Chee Sung; Park, Cyn-Young

    2009-01-01

    The main objective of this paper is to suggest reform measures to address the gaps and weaknesses in emerging Asia's financial regulatory and supervisory systems, on the basis of lessons drawn from the global crisis. For emerging Asia, the direct impact of the global financial crisis has been limited, thus generating substantially less pressure for financial restructuring and regulatory reform than is the case in developed economies. However, the underlying causes of the current turmoil—such ...

  16. (Q)SAR modeling and safety assessment in regulatory review.

    Science.gov (United States)

    Kruhlak, N L; Benz, R D; Zhou, H; Colatsky, T J

    2012-03-01

    The ability to predict clinical safety based on chemical structures is becoming an increasingly important part of regulatory decision making. (Quantitative) structure-activity relationship ((Q)SAR) models are currently used to evaluate late-arising safety concerns and possible nonclinical effects of a drug and its related compounds when adequate safety data are absent or equivocal. Regulatory use will likely increase with the standardization of analytical approaches, more complete and reliable data collection methods, and a better understanding of toxicity mechanisms.

  17. Balancing Europe's wind power output through spatial deployment informed by weather regimes.

    Science.gov (United States)

    Grams, Christian M; Beerli, Remo; Pfenninger, Stefan; Staffell, Iain; Wernli, Heini

    2017-08-01

    As wind and solar power provide a growing share of Europe's electricity1, understanding and accommodating their variability on multiple timescales remains a critical problem. On weekly timescales, variability is related to long-lasting weather conditions, called weather regimes2-5, which can cause lulls with a loss of wind power across neighbouring countries6. Here we show that weather regimes provide a meteorological explanation for multi-day fluctuations in Europe's wind power and can help guide new deployment pathways which minimise this variability. Mean generation during different regimes currently ranges from 22 GW to 44 GW and is expected to triple by 2030 with current planning strategies. However, balancing future wind capacity across regions with contrasting inter-regime behaviour - specifically deploying in the Balkans instead of the North Sea - would almost eliminate these output variations, maintain mean generation, and increase fleet-wide minimum output. Solar photovoltaics could balance low-wind regimes locally, but only by expanding current capacity tenfold. New deployment strategies based on an understanding of continent-scale wind patterns and pan-European collaboration could enable a high share of wind energy whilst minimising the negative impacts of output variability.

  18. Food crises, food regimes and food movements: rumblings of reform or tides of transformation?

    Science.gov (United States)

    Holt Giménez, Eric; Shattuck, Annie

    2011-01-01

    This article addresses the potential for food movements to bring about substantive changes to the current global food system. After describing the current corporate food regime, we apply Karl Polanyi's 'double-movement' thesis on capitalism to explain the regime's trends of neoliberalism and reform. Using the global food crisis as a point of departure, we introduce a comparative analytical framework for different political and social trends within the corporate food regime and global food movements, characterizing them as 'Neoliberal', 'Reformist', 'Progressive', and 'Radical', respectively, and describe each trend based on its discourse, model, and key actors, approach to the food crisis, and key documents. After a discussion of class, political permeability, and tensions within the food movements, we suggest that the current food crisis offers opportunities for strategic alliances between Progressive and Radical trends within the food movement. We conclude that while the food crisis has brought a retrenchment of neoliberalization and weak calls for reform, the worldwide growth of food movements directly and indirectly challenge the legitimacy and hegemony of the corporate food regime. Regime change will require sustained pressure from a strong global food movement, built on durable alliances between Progressive and Radical trends.

  19. Choice of exchange rate regimes for African countries: Fixed or Flexible Exchange rate regimes?

    OpenAIRE

    Simwaka, Kisu

    2010-01-01

    The choice of an appropriate exchange rate regime has been a subject of ongoing debate in international economics. The majority of African countries are small open economies and thus where the choice of the exchange rate regime is an important policy issue. Aside from factors such as interest rates and inflation, the exchange rate is one of the most important determinants of a country’s relative level of economic health. For this reason, exchange rates are among the most watched analyzed and ...

  20. Steam Generator tube integrity -- US Nuclear Regulatory Commission perspective

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, E.L.; Sullivan, E.J.

    1997-02-01

    In the US, the current regulatory framework was developed in the 1970s when general wall thinning was the dominant degradation mechanism; and, as a result of changes in the forms of degradation being observed and improvements in inspection and tube repair technology, the regulatory framework needs to be updated. Operating experience indicates that the current U.S. requirements should be more stringent in some areas, while in other areas they are overly conservative. To date, this situation has been dealt with on a plant-specific basis in the US. However, the NRC staff is now developing a proposed steam generator rule as a generic framework for ensuring that the steam generator tubes are capable of performing their intended safety functions. This paper discusses the current U.S. regulatory framework for assuring steam generator (SG) tube integrity, the need to update this regulatory framework, the objectives of the new proposed rule, the US Nuclear Regulatory Commission (NRC) regulatory guide (RG) that will accompany the rule, how risk considerations affect the development of the new rule, and some outstanding issues relating to the rule that the NRC is still dealing with.

  1. Regulatory mark; Marco regulatorio

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-10-15

    This chapter is based on a work performed in distinct phases. The first phase consisted in of the analysis regulatory legislation existent in Brazil for the sugar-alcohol sector since the beginning of the X X century. This analysis allowed the identification of non existent points and legal devices related to the studied aspects, and that were considered as problematic for the sector expansion. In the second phase, related treaties and international agreements was studied and possible obstacles for the brazilian bio ethanol exportation for the international market. Initiatives were examined at European Union, United States of America, Caribbean and countries of the sub-Saharan Africa. In this phase, policies were identified related to the incentives and adoption of use of bio fuels added to the gasoline in countries or group of countries considered as key for the consolidation of bio ethanol as a world commodity.

  2. 75 FR 54210 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of...

    Science.gov (United States)

    2010-09-03

    ...-2010-032] Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of... Transactions August 30, 2010. On June 17, 2010, the Financial Industry Regulatory Authority, Inc....

  3. Regime variance testing - a quantile approach

    CERN Document Server

    gajda, Janusz; Wyłomańska, Agnieszka

    2012-01-01

    This paper is devoted to testing time series that exhibit behavior related to two or more regimes with different statistical properties. Motivation of our study are two real data sets from plasma physics with observable two-regimes structure. In this paper we develop estimation procedure for critical point of division the structure change of a time series. Moreover we propose three tests for recognition such specific behavior. The presented methodology is based on the empirical second moment and its main advantage is lack of the distribution assumption. Moreover, the examined statistical properties we express in the language of empirical quantiles of the squared data therefore the methodology is an extension of the approach known from the literature. The theoretical results we confirm by simulations and analysis of real data of turbulent laboratory plasma.

  4. Regimes de espaço

    Directory of Open Access Journals (Sweden)

    Eric Landowski

    2015-06-01

    Full Text Available Space Regimes - Based on a general model of interaction, the present analysis attempts to account for the diversity of the ways space may be apprehended in lived experience. It leads to the definition of four configurations that correspond to as many regimes of relation with the environing world. The conventional space of the circulation of values takes the archetypical shape of the net (incarnated today by Internet. The operational space is that of our dealing with objects within a material environment seen as a tissue of stable and intelligible relations. The experienced space of bodies’ movement, to which one may give as an emblem the spiral, expresses the dynamics of sensitive relationships between the self and the other. The existential space is that of our presence in a universe without boundaries, which no one can properly represent oneself but that nonetheless haunts art and thought: its figure is the abyss.

  5. Online recognition of the multiphase flow regime

    Institute of Scientific and Technical Information of China (English)

    BAI BoFeng; ZHANG ShaoJun; ZHAO Liang; ZHANG XiMin; GUO LieJin

    2008-01-01

    The key reasons that the present method cannot be used to solve the industrial multi-phase flow pattern recognition are clarified firstly. The prerequisite to realize the online recognition is proposed and recognition rules for partial flow pattern are obtained based on the massive experimental data. The standard templates for every flow regime feature are calculated with self-organization cluster algorithm. The multi-sensor data fusion method is proposed to realize the online recognition of multiphase flow regime with the pressure and differential pressure signals, which overcomes the severe influence of fluid flow velocity and the oil fraction on the recognition. The online recognition method is tested in the practice, which has less than 10 percent measurement error. The method takes advantages of high confidence, good fault tolerance and less requirement of single sensor performance.

  6. Online recognition of the multiphase flow regime

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The key reasons that the present method cannot be used to solve the industrial multi- phase flow pattern recognition are clarified firstly. The prerequisite to realize the online recognition is proposed and recognition rules for partial flow pattern are obtained based on the massive experimental data. The standard templates for every flow regime feature are calculated with self-organization cluster algorithm. The multi-sensor data fusion method is proposed to realize the online recognition of multiphase flow regime with the pressure and differential pressure signals, which overcomes the severe influence of fluid flow velocity and the oil fraction on the recognition. The online recognition method is tested in the practice, which has less than 10 percent measurement error. The method takes advantages of high confidence, good fault tolerance and less requirement of single sensor performance.

  7. Cluster analysis of multiple planetary flow regimes

    Science.gov (United States)

    Mo, Kingtse; Ghil, Michael

    1988-01-01

    A modified cluster analysis method developed for the classification of quasi-stationary events into a few planetary flow regimes and for the examination of transitions between these regimes is described. The method was applied first to a simple deterministic model and then to a 500-mbar data set for Northern Hemisphere (NH), for which cluster analysis was carried out in the subspace of the first seven empirical orthogonal functions (EOFs). Stationary clusters were found in the low-frequency band of more than 10 days, while transient clusters were found in the band-pass frequency window between 2.5 and 6 days. In the low-frequency band, three pairs of clusters determined EOFs 1, 2, and 3, respectively; they exhibited well-known regional features, such as blocking, the Pacific/North American pattern, and wave trains. Both model and low-pass data exhibited strong bimodality.

  8. Flamelet Regime Diagram for Turbulent Combustion Simulations

    Science.gov (United States)

    Chan, Wai Lee; Ihme, Matthias; Kolla, Hemanth; Chen, Jacqueline

    2016-11-01

    The flamelet model has been widely used in numerical combustion investigations, particularly for the closure of large-eddy simulations (LES) of turbulent reacting flows. In most cases, the simulation results demonstrated good agreements with their experimental counterparts. However, a systematic analysis of the flamelet model's applicability, as well as its potential limitations, is seldom conducted, and the model performance is usually based only on a-posteriori comparisons. The objective of this work is to derive a metric that can formally quantify the suitability of the flamelet model in different flame configurations. For this purpose, a flamelet regime diagram has been developed and studied in the context of direct numerical simulations (DNS) of a turbulent lifted jet flame. The implementation of the regime diagram in LES has been investigated through explicit filtering of the DNS results.

  9. Stochastic Functional Differential Equation under Regime Switching

    Directory of Open Access Journals (Sweden)

    Ling Bai

    2012-01-01

    Full Text Available We discuss stochastic functional differential equation under regime switching dx(t=f(xt,r(t,tdt+q(r(tx(tdW1(t+σ(r(t|x(t|βx(tdW2(t. We obtain unique global solution of this system without the linear growth condition; furthermore, we prove its asymptotic ultimate boundedness. Using the ergodic property of the Markov chain, we give the sufficient condition of almost surely exponentially stable of this system.

  10. Effect of water regime on poplar cultivation

    Directory of Open Access Journals (Sweden)

    Letić Ljubomir

    2006-01-01

    Full Text Available The effect of water regime on the growth and development of plantations of hydrologically conditioned species, poplars was researched in the alluvial plain of the river Tamiš. The investigations were carried out during the period 2000-2003 on the area of FA "Opovo", KO Sakule, and the study results elucidate the very complex relationships between the hydrological conditions of the site and the growth and increment of the study poplar plantations, cl. I-214. .

  11. Fiscal Policy Regimes and Household Consumption

    OpenAIRE

    Jönsson, Kristian

    2004-01-01

    In this paper, we study the effects of fiscal policy during different fiscal policy regimes. More specifically, we investigate how different factors, such as size, duration and composition of fiscal changes, can alter the effects of fiscal policy on private consumption. Using an unbalanced panel of 19 OECD countries during the period 1960-2000, we find that transfer changes are believed to be permanent during fiscal contractions. Hence, it is more likely that an expansionary fiscal contractio...

  12. Deuteron structure in the deep inelastic regime

    CERN Document Server

    Canal, C A Garcìa; Vento, V

    2016-01-01

    We study nuclear effects on the deuteron in the deep inelastic regime using the newest available data analyzing their $Q^2$ dependence. We conclude that precise EMC ratios for large $Q^2$ (> 30, GeV$^2$) cannot be obtained without considering these nuclear effects. For this purpose we use a scheme which parametrizes these effects in a simple manner and compare our results with other recent proposals.

  13. Economic Performance and North Korean Regime Legitimacy

    Science.gov (United States)

    2014-06-01

    As Cha and Anderson note, free markets have become the reliable means of survival in North Korea and these “markets create entrepreneurship , and... entrepreneurship creates an individualist way of thinking alien to the government.”9 If this case is true, the regime’s demise could very well be at...arguments on how the regime works, what has driven its survival, and the social and economic situations that have developed as a result. D. THESIS

  14. Dynamic Regime of Ignition of Solid Propellant

    Directory of Open Access Journals (Sweden)

    Zolotorev Nikolay

    2016-01-01

    Full Text Available This article presents a dynamic regime of exposure of the radiant flux on the sample of gun-cotton. Obtained time the ignition of gun-cotton in the heating conditions of increasing heat flux in the range from 0.2 W/cm2 to 22 W/cm2. A comparison of the delay times of the ignition when heated variable and constant heat flux.

  15. Ion Acceleration in the Laser Transparency Regime

    OpenAIRE

    Steinke, Sven

    2011-01-01

    Im Rahmen dieser Arbeit wurden neue, verbesserte Ansätze zur Ionenbeschleunigung mit kurzen, intensiven Laser Pulsen untersucht und charakterisiert. Die verwendeten Laser Pulse mit relativistischer Intensität und sehr hohem Intensitätskontrast ermöglichten die Verwendung von Folien-Targets mit Dicken unterhalb der Eindringtiefe des Laserspulses (~nm) und somit erstmals Experimente im sog transparenten Regime. Im Gegensatz zu undurchsichtigen, dicken Folientargets, erlauben transparente Target...

  16. Charging regime of pur spinel studied by secondary electron emission

    Energy Technology Data Exchange (ETDEWEB)

    Boughariou, A., E-mail: aicha_boughariou@yahoo.fr [LaMaCoP, Université de Sfax pour le sud, Faculté des Sciences, 3038 Sfax (Tunisia); Kallel, A. [LaMaCoP, Université de Sfax pour le sud, Faculté des Sciences, 3038 Sfax (Tunisia); Blaise, G. [LPS, Université Paris-Sud XI, Batiment 510, Orsay 91405 (France)

    2013-04-01

    Insulators are currently used in high technological devices. They are chosen because of their electrical properties of insulation and their thermal properties. It is well known that the presence of space charge in an insulator is correlated with an electric breakdown. Charging phenomena of insulator were studied thanks to a scanning electron microscope (SEM) which allows the injection of few electrons doses in a large domain of energies. SEM permits also the measurements of the secondary electron emission and the induced current created in the sample holder by the charges generated in the sample. The results showed that the secondary electron emission yield (SEE) σ is a very sensitive parameter to characterize the charging state of an insulator. In this work we investigate the charging effect of insulator surfaces like pur spinel (MgAl{sub 2}O{sub 4}) during 1.1, 5 and 15 keV. The results showed that the fundamental parameter controlling the charging kinetic is the current density J{sub 0}. At low energies 1.1 and 5 keV, two different kinds of self-regulated regime (σ=1) were observed as a function of current density. At 15 keV energy, the electron emission appears to be stimulated by the current density, due to the Poole–Frenkel effect.

  17. Lubrication regimes in lumbar total disc arthroplasty.

    Science.gov (United States)

    Shaheen, A; Shepherd, D E T

    2007-08-01

    A number of total disc arthroplasty devices have been developed. Some concern has been expressed that wear may be a potential failure mode for these devices, as has been seen with hip arthroplasty. The aim of this paper was to investigate the lubrication regimes that occur in lumbar total disc arthroplasty devices. The disc arthroplasty was modelled as a ball-and-socket joint. Elastohydrodynamic lubrication theory was used to calculate the minimum film thickness of the fluid between the bearing surfaces. The lubrication regime was then determined for different material combinations, size of implant, and trunk velocity. Disc arthroplasties with a metal-polymer or metal-metal material combination operate with a boundary lubrication regime. A ceramic-ceramic material combination has the potential to operate with fluid-film lubrication. Disc arthroplasties with a metal-polymer or metal-metal material combination are likely to generate wear debris. In future, it is worth considering a ceramic-ceramic material combination as this is likely to reduce wear.

  18. Utilizing Surface Sensors to Identify Wake Regimes

    Science.gov (United States)

    Wang, Mengying; Hemati, Maziar S.

    2016-11-01

    Marine swimmers often exploit external flow structures to reduce locomotive effort. To achieve this advantage, these swimmers utilize mechanosensory organs on the surface of their bodies to detect hydrodynamic signals from the surrounding fluid, which can then be used to inform the control task. Recently, there has been a growing interest in developing similar flow sensing systems to achieve enhanced propulsive efficiency and maneuverability in human-engineered underwater vehicles. In particular, much attention has been given to the problem of wake sensing; however, these investigations have concentrated on a restricted class of wakes-i.e., Kármán-type vortex streets-whereas more complicated wake structures can arise in practice. In this talk, we will explore the possibility of identifying wake regimes through the use of surface sensors. Potential flow theory is adopted to simulate the interactions of various wakes with a fish-like body. Wakes in different dynamical regimes impart distinct hydrodynamic signatures on the body, which permits these regimes to be distinguished from one another in an automated fashion. Our results can provide guidance for improving flow sensing capabilities in human-engineered systems and hint at how marine swimmers may sense their hydrodynamic surroundings.

  19. QCD in the {delta}-regime

    Energy Technology Data Exchange (ETDEWEB)

    Bietenholz, W. [Universidad Nacional Autonoma de Mexico, Mexico City (Mexico). Inst. de Ciencias Nucleares; Cundy, N. [Seoul National Univ. (Korea, Republic of). Lattice Gauge Theory Research Center; Goeckeler, M. [Regensburg Univ. (Germany). Inst. fuer Theoretische Physik; Horsley, R.; Zanotti, J.M. [Edinburgh Univ. (United Kingdom). School of Physics; Nakamura, Y. [Tsukuba Univ., Ibaraki (Japan). Center for Computational Sciences; Pleiter, D. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Rakow, P.E.L. [Liverpool Univ. (United Kingdom). Theoretical Physics Div.; Schierholz, G. [Regensburg Univ. (Germany). Inst. fuer Theoretische Physik; Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2011-03-15

    The {delta}-regime of QCD is characterised by light quarks in a small spatial box, but a large extent in (Euclidean) time. In this setting a specific variant of chiral perturbation theory - the {delta}-expansion - applies, based on a quantum mechanical treatment of the quasi onedimensional system. In particular, for vanishing quark masses one obtains a residual pion mass M{sup R}{sub {pi}}, which has been computed to the third order in the {delta}-expansion. A comparison with numerical measurements of this residual mass allows for a new determination of some Low Energy Constants, which appear in the chiral Lagrangian. We first review the attempts to simulate 2-flavour QCD directly in the {delta}-regime. This is very tedious, but results compatible with the predictions for M{sup R}{sub {pi}} have been obtained. Then we show that an extrapolation of pion masses measured in a larger volume towards the {delta}-regime leads to good agreement with the theoretical predictions. From those results, we also extract a value for the (controversial) sub-leading Low Energy Constant anti l{sub 3}. (orig.)

  20. Dynamics of skyrmions and edge states in the resistive regime of mesoscopic p-wave superconductors

    Science.gov (United States)

    Fernández Becerra, V.; Milošević, M. V.

    2017-02-01

    In a mesoscopic sample of a chiral p-wave superconductor, novel states comprising skyrmions and edge states have been stabilized in out-of-plane applied magnetic field. Using the time-dependent Ginzburg-Landau equations we shed light on the dynamic response of such states to an external applied current. Three different regimes are obtained, namely, the superconducting (stationary), resistive (non-stationary) and normal regime, similarly to conventional s-wave superconductors. However, in the resistive regime and depending on the external current, we found that moving skyrmions and the edge state behave distinctly different from the conventional kinematic vortex, thereby providing new fingerprints for identification of p-wave superconductivity.

  1. Emerging regulatory paradigms in glutathione metabolism

    Science.gov (United States)

    Liu, Yilin; Hyde, Annastasia S.; Simpson, Melanie A.; Barycki, Joseph J.

    2015-01-01

    One of the hallmarks of cancer is the ability to generate and withstand unusual levels of oxidative stress. In part, this property of tumor cells is conferred by elevation of the cellular redox buffer glutathione. Though enzymes of the glutathione synthesis and salvage pathways have been characterized for several decades, we still lack a comprehensive understanding of their independent and coordinate regulatory mechanisms. Recent studies have further revealed that overall central metabolic pathways are frequently altered in various tumor types, resulting in significant increases in biosynthetic capacity, and feeding into glutathione synthesis. In this review, we will discuss the enzymes and pathways affecting glutathione flux in cancer, and summarize current models for regulating cellular glutathione through both de novo synthesis and efficient salvage. In addition, we examine the integration of glutathione metabolism with other altered fates of intermediary metabolites, and highlight remaining questions about molecular details of the accepted regulatory modes. PMID:24974179

  2. Regulatory mechanisms link phenotypic plasticity to evolvability.

    Science.gov (United States)

    van Gestel, Jordi; Weissing, Franz J

    2016-04-18

    Organisms have a remarkable capacity to respond to environmental change. They can either respond directly, by means of phenotypic plasticity, or they can slowly adapt through evolution. Yet, how phenotypic plasticity links to evolutionary adaptability is largely unknown. Current studies of plasticity tend to adopt a phenomenological reaction norm (RN) approach, which neglects the mechanisms underlying plasticity. Focusing on a concrete question - the optimal timing of bacterial sporulation - we here also consider a mechanistic approach, the evolution of a gene regulatory network (GRN) underlying plasticity. Using individual-based simulations, we compare the RN and GRN approach and find a number of striking differences. Most importantly, the GRN model results in a much higher diversity of responsive strategies than the RN model. We show that each of the evolved strategies is pre-adapted to a unique set of unseen environmental conditions. The regulatory mechanisms that control plasticity therefore critically link phenotypic plasticity to the adaptive potential of biological populations.

  3. Metabolic constraint-based refinement of transcriptional regulatory networks.

    Science.gov (United States)

    Chandrasekaran, Sriram; Price, Nathan D

    2013-01-01

    There is a strong need for computational frameworks that integrate different biological processes and data-types to unravel cellular regulation. Current efforts to reconstruct transcriptional regulatory networks (TRNs) focus primarily on proximal data such as gene co-expression and transcription factor (TF) binding. While such approaches enable rapid reconstruction of TRNs, the overwhelming combinatorics of possible networks limits identification of mechanistic regulatory interactions. Utilizing growth phenotypes and systems-level constraints to inform regulatory network reconstruction is an unmet challenge. We present our approach Gene Expression and Metabolism Integrated for Network Inference (GEMINI) that links a compendium of candidate regulatory interactions with the metabolic network to predict their systems-level effect on growth phenotypes. We then compare predictions with experimental phenotype data to select phenotype-consistent regulatory interactions. GEMINI makes use of the observation that only a small fraction of regulatory network states are compatible with a viable metabolic network, and outputs a regulatory network that is simultaneously consistent with the input genome-scale metabolic network model, gene expression data, and TF knockout phenotypes. GEMINI preferentially recalls gold-standard interactions (p-value = 10(-172)), significantly better than using gene expression alone. We applied GEMINI to create an integrated metabolic-regulatory network model for Saccharomyces cerevisiae involving 25,000 regulatory interactions controlling 1597 metabolic reactions. The model quantitatively predicts TF knockout phenotypes in new conditions (p-value = 10(-14)) and revealed potential condition-specific regulatory mechanisms. Our results suggest that a metabolic constraint-based approach can be successfully used to help reconstruct TRNs from high-throughput data, and highlights the potential of using a biochemically-detailed mechanistic framework to

  4. Hydrodynamic Regimes Affect Coral Reef Resilience to Ocean Acidification

    Science.gov (United States)

    Teneva, L. T.; Dunbar, R. B.; Koseff, J. R.; Fleischfresser, J. D.; Koweek, D.

    2013-05-01

    Caribbean reefs hold tremendous value as sources of food, income, coastal protection, in addition to their cultural significance. Recently, studies showed that Caribbean reef growth has been surpassed in places by excessive rates of erosion due to climate change. The rates of coral reef response to ocean pH changes and warming and the implications for ecosystem resilience remain largely unknown. One way to investigate the potential structural resilience of reefs to climate change is to measure the physical oceanographic conditions in the area. Determining the hydrodynamic regimes and residence time of water in a particular reef environment is crucial to understanding the rates of future warming and acidification a reef site would experience. Our work on Pacific Islands' hydrodynamics - Central Equatorial Pacific, Great Barrier Reef, and Western Pacific -- would be of interest to Caribbean physical oceanographers and coral reef scientists. We use a combination of Acoustic Doppler Current Profilers, Acoustic Doppler Velocimeters, temperature and salinity sensors, and pressure sensors to characterize reef hydrodynamic regimes. Our work indicates that shallower, more protected reef habitats are characterized by longer residence times, their biological signals are strongly tidally modulated, essentially subjecting such habitats to higher rates of warming and acidification in the future. Reef crest environments and fore reef habitats, on the other hand, are well-mixed with open-ocean water. The hydrodynamic regimes there condition such reef sites to more attenuated temperature and pH ranges, conditions more typical of the open ocean. Our work suggests that investigating the geomorphology and resulting localized hydrodynamics in a reef area can provide insights into the relative rates at which a reef could resist or succumb to impacts of ocean acidification. Such information for different reef islands, in the Pacific or Caribbean basins, could provide helpful insights

  5. Two regimes of the Arctic's circulation from ocean models with ice and contaminants.

    Science.gov (United States)

    Proshutinsky, A Y; Johnson, M

    2001-01-01

    A two-dimensional barotropic, coupled, ocean-ice model with a space resolution of 55.5 km and driven by atmospheric forces, river run-off, and sea-level slope between the Pacific and the Arctic Oceans, has been used to simulate the vertically averaged currents and ice drift in the Arctic Ocean. Results from 43 years of numerical simulations of water and ice motions demonstrate that two wind-driven circulation regimes are possible in the Arctic, a cyclonic and an anti-cyclonic circulation. These two regimes appear to alternate at 5-7 year intervals with the 10-15 year period. It is important to pollution studies to understand which circulation regime prevails at any time. It is anticipated that 1995 is a year with a cyclonic regime, and during this cyclonic phase and possibly during past cyclonic regimes as well, pollutants may reach the Alaskan shelf. The regime shifts demonstrated in this paper are fundamentally important to understanding the Arctic's general circulation and particularly important for estimating pollution transport.

  6. The importance of within-system spatial variation in drivers of marine ecosystem regime shifts

    Science.gov (United States)

    Fisher, J. A. D.; Casini, M.; Frank, K. T.; Möllmann, C.; Leggett, W. C.; Daskalov, G.

    2015-01-01

    Comparative analyses of the dynamics of exploited marine ecosystems have led to differing hypotheses regarding the primary causes of observed regime shifts, while many ecosystems have apparently not undergone regime shifts. These varied responses may be partly explained by the decade-old recognition that within-system spatial heterogeneity in key climate and anthropogenic drivers may be important, as recent theoretical examinations have concluded that spatial heterogeneity in environmental characteristics may diminish the tendency for regime shifts. Here, we synthesize recent, empirical within-system spatio-temporal analyses of some temperate and subarctic large marine ecosystems in which regime shifts have (and have not) occurred. Examples from the Baltic Sea, Black Sea, Bengula Current, North Sea, Barents Sea and Eastern Scotian Shelf reveal the largely neglected importance of considering spatial variability in key biotic and abiotic influences and species movements in the context of evaluating and predicting regime shifts. We highlight both the importance of understanding the scale-dependent spatial dynamics of climate influences and key predator–prey interactions to unravel the dynamics of regime shifts, and the utility of spatial downscaling of proposed mechanisms (as evident in the North Sea and Barents Sea) as a means of evaluating hypotheses originally derived from among-system comparisons.

  7. THE CONCEPT OF THE LEGAL REGIME OF HIGH RISK REAL ESTATE

    Directory of Open Access Journals (Sweden)

    Abramov V. V.

    2015-03-01

    Full Text Available The identity of the property of high risk to the objects of civil rights has been proved in the article. No doubt that there is a necessity of separation of static and dynamic units in the civil-law mode of real things of increased risk. However, currently these components are not sufficient for full civil and legal characteristics. Suggestions for improving the structure of the real objects of civil rights are proposed by the author. The article considers the civil-law regime of real estate of high risk as a legal phenomenon of a systemic nature. Risk is a system element of the legal regime of particularly dangerous real estate. Different types of risks in the content of the legal regime of these things are interconnected in a close relationship. The value of the category of "risk" in the legal regime is associated with compensation for damage caused by its operation. Another part of the problem is associated with civil-legal regulation of property to such objects of civil law. The author's understanding of the structural elements of a civil-law regime of such things and their interrelations is proposed. This representation of the structure of civil-legal regime of immovable properties increased risk allows to take into account particular things as objects of civil rights in all sections of civil reality

  8. THE CONCEPT OF THE LEGAL REGIME OF REAL ESTATE HIGH RISK

    Directory of Open Access Journals (Sweden)

    Abramov V. V.

    2015-02-01

    Full Text Available The identity of the property increased risk to the objects of civil rights is proved in the article. No doubt the necessity of separation of static and dynamic units in the civil-law mode of real things of increased risk. However, currently these components are not sufficient for full civil and legal characteristics. Suggestions for improving the structure of the real objects of civil rights are proposed by the author. The article considers the civil-law regime of real estate high risk as a legal phenomenon of a systemic nature. Risk is a system element of the regime particularly dangerous real estate. Different types of risks in the content of the legal regime of these things are interconnected in a close relationship. Value category of "risk" in the legal regime associated with compensation for damage caused by its operation. Another part of the problem associated with civil-legal regulation of property rights to such objects of civil law. The author's understanding of the structural elements of a civil-law regime of such things and their interrelations is proposed. This representation of the structure of civil-legal regime of immovable properties increased risk allows to take into account particular things as objects of civil rights in all sections of civil reality

  9. Regulatory focus in groupt contexts

    NARCIS (Netherlands)

    Faddegon, Krispijn Johannes

    2009-01-01

    The thesis examines the influence of group processes on the regulatory focus of individual group members. It is demonstrated that the group situation can affect group members' regulatory focus both in a top-down fashion (via the identitiy of the group) and in a bottom-up fashion (emerging from the g

  10. Reconsidering Styles of Regulatory Enforcement

    DEFF Research Database (Denmark)

    May, Peter J.; Winter, Søren

    2000-01-01

    This study addresses enforcement styles of regulatory inspectors, based on an examination of the municipal enforcement of agro-environmental policies in Denmark. Our findings make three contributions to the regulatory literature. One contribution is to add empirical support for theorizing about i...

  11. Reconsidering Styles of Regulatory Enforcement

    DEFF Research Database (Denmark)

    J. May, Peter; Winter, Søren

    2007-01-01

    This study addresses enforcement styles of regulatory inspectors based on an examination of the municipal enforcement of agro-environmental policies in Denmark. Our findings make three contributions to the regulatory literature. One contribution is to add empirical support for theorizing about in...

  12. Regulatory Foci and Organizational Commitment

    Science.gov (United States)

    Markovits, Yannis; Ullrich, Johannes; van Dick, Rolf; Davis, Ann J.

    2008-01-01

    We use regulatory focus theory to derive specific predictions regarding the differential relationships between regulatory focus and commitment. We estimated a structural equation model using a sample of 520 private and public sector employees and found in line with our hypotheses that (a) promotion focus related more strongly to affective…

  13. Disclosure as a regulatory tool

    DEFF Research Database (Denmark)

    2006-01-01

    The chapter analyses how disclure can be used as a regulatory tool and analyses how it has been applied so far in the area of financial market law and consumer law.......The chapter analyses how disclure can be used as a regulatory tool and analyses how it has been applied so far in the area of financial market law and consumer law....

  14. Anti-regulatory T cells

    DEFF Research Database (Denmark)

    Andersen, Mads Hald

    2017-01-01

    Our initial understanding of immune-regulatory cells was based on the discovery of suppressor cells that assure peripheral T-cell tolerance and promote immune homeostasis. Research has particularly focused on the importance of regulatory T cells (Tregs) for immune modulation, e.g. directing host...... responses to tumours or inhibiting autoimmunity development. However, recent studies report the discovery of self-reactive pro-inflammatory T cells—termed anti-regulatory T cells (anti-Tregs)—that target immune-suppressive cells. Thus, regulatory cells can now be defined as both cells that suppress immune...... reactions as well as effector cells that counteract the effects of suppressor cells and support immune reactions. Self-reactive anti-Tregs have been described that specifically recognize human leukocyte antigen-restricted epitopes derived from proteins that are normally expressed by regulatory immune cells...

  15. A new fast reconnection model in a collisionless regime

    CERN Document Server

    Tsiklauri, David

    2008-01-01

    Based on the first principles (by balancing the advection with the electron pressure tensor in the generalised Ohm's law, and using the conservation of mass) a simple model of magnetic reconnection in a collisionless regime is formulated. In addition to its importance from the fundamental point of view, the collisionless reconnection model offers a much faster reconnection rate ($M_{c'less}={(d_i/2)}^{1/2}$) than Sweet-Parker's classical one ($M_{sp}=S^{-1/2}$). The width of the diffusion region (current sheet) in the collisionless regime is found to be $\\delta_{c'less}={(d_i/2)}^{1/2}L$, which is much larger than the Sweet-Parker width ($\\delta_{sp}=S^{-1/2}L$) for the space plasma conditions. Amongst other issues, this alleviates e.g. the problem of interpretation of solar flares by means of reconnection, as for the typical solar coronal parameters the obtained collisionless reconnection time can be $< 10$ minutes, as opposed to Sweet-Parker's equivalent value of $<$ year. The new theoretical reconnec...

  16. Evolution and resilience of the nuclear nonproliferation regime

    Energy Technology Data Exchange (ETDEWEB)

    Pregenzer, Arian L. [Senior Scientist, Retired, Sandia National Laboratories, 13013 Arroyo de Vista NE, Albuquerque, NM 87111 (United States)

    2014-05-09

    This paper introduces the concept of systems resilience as a new framework for thinking about the future of the nonproliferation regime. Resilience refers to the ability of a system to maintain its vital functions in the face of continuous and unpredictable change. First, I make the case that the nonproliferation regime can be viewed as a complex system. Next, I discuss key themes from the literature on systems resilience and apply them to the nonproliferation system: the difference between resilience and stability; the need for evolution to maintain function; the importance of functional diversity; and the concept of the adaptive cycle. I show that most existing nonproliferation strategies are aimed at stability rather than resilience and that the current nonproliferation system may be over-constrained by the cumulative evolution of strategies. According to the literature on systems resilience, this increases its vulnerability to collapse. I argue that the resilience of the nonproliferation system can be enhanced by increasing international participation in setting the nonproliferation agenda, developing general international response capabilities, focusing on non-coercive approaches to decreasing demand, and applying systems thinking more rigorously to nonproliferation.

  17. Transformational Change and Regime Shifts in the Circumpolar Arctic

    Directory of Open Access Journals (Sweden)

    Annika E. Nilsson

    2016-11-01

    Full Text Available The Arctic is changing rapidly, and there are many indications that the region is in the midst of transformational change. While some of the focus relates to impacts of climate change, rapid economic development and the potential for shifts in political and social structures in the region have also been in the limelight. This article looks at the circumpolar Arctic as a potential case of a regime shift in a large-scale social–ecological system that includes reinforcing feedbacks. A special focus is placed on governance structures, as these play an important role in social negotiations on the relationship between societies and the environment. While climate change is often portrayed as a driver of social change in the Arctic, it does not appear that the ongoing changes in the biophysical features of the Arctic region have rocked current circumpolar governance structures out of kilter. On the contrary, the ongoing climate-related changes, in particular sea ice decline, appear to have reinforced political commitment to existing legal structures. Major past social regime shifts have mainly been related to access to resources and national identity ideology, with political dynamics reinforced at times by military security considerations.

  18. Consequences of more extreme precipitation regimes for terrestrial ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    Knapp, Alan [Colorado State University, Fort Collins; Beier, Claus [Riso National Laboratory, Roskilde, Denmark; Briske, David [Texas A& M University; Classen, Aimee T [ORNL; Luo, Yiqi [University of Oklahoma; Reichstein, Markus [Max Planck Institute for Biogeochemistry; Smith, Melinda D [Yale University; Smith, Stanley D [University of Nevada, Las Vegas; Bell, Jesse E [University of Oklahoma; Fay, Philip [ORNL; Heisler, Jana A [Colorado State University, Fort Collins; Leavitt, Steven W [unknown; Sherry, Rebecca [University of Oklahoma; Smith, Ben [unknown; Weng, Ensheng [University of Oklahoma, Norman; Norby, Richard J [ORNL

    2008-09-01

    Amplification of the hydrological cycle, as a consequence of global warming, is forecast to be manifest not only by alterations in total annual precipitation, but also through more extreme precipitation regimes characterized by larger rainfall events and more severe intervening drought periods. Based on past studies and theory, we present a conceptual framework for predicting the consequences of this projected change in intra-annual rainfall patterns for terrestrial ecosystems arrayed along a broad gradient in water availability. More extreme rainfall regimes are predicted to increase the occurrence of periodic soil water stress in mesic ecosystems due to prolonged dry periods between rainfall events. In contrast, xeric ecosystems may exhibit the opposite response because a shift to a greater proportion of rainfall delivered in large precipitation events will result in reduced proportional evaporative losses per storm event and greater soil water storage, alleviating soil water stress for longer periods of time. Hydric ecosystems may experience reduced periods of anoxia if intervals between rainfall events increase. This contingent effect of the overall soil water balance on ecosystem responses will likely cascade through all hierarchical levels of ecological processes and interact in ways currently unknown with related global change drivers such as elevated atmospheric temperatures and CO2 concentrations. Thus, multi-factor comparative experiments and systems modeling approaches are needed to more fully understand and forecast the potential ecological consequences of this underappreciated aspect of climate change.

  19. Regulatory Streamlining and Improvement

    Energy Technology Data Exchange (ETDEWEB)

    Mark A. Carl

    2006-07-11

    The Interstate Oil and Gas Compact Commission (IOGCC) engaged in numerous projects outlined under the scope of work discussed in the United States Department of Energy (DOE) grant number DE-FC26-04NT15456 awarded to the IOGCC. Numerous projects were completed that were extremely valuable to state oil and gas agencies as a result of work performed utilizing resources provided by the grant. There are numerous areas in which state agencies still need assistance. This additional assistance will need to be addressed under future scopes of work submitted annually to DOE's Project Officer for this grant. This report discusses the progress of the projects outlined under the grant scope of work for the 2005-2006 areas of interest, which are as follows: Area of Interest No. 1--Regulatory Streamlining and Improvement: This area of interest continues to support IOGCC's regulatory streamlining efforts that include the identification and elimination of unnecessary duplications of efforts between and among state and federal programs dealing with exploration and production on public lands. Area of Interest No. 2--Technology: This area of interest seeks to improve efficiency in states through the identification of technologies that can reduce costs. Area of Interest No. 3--Training and Education: This area of interest is vital to upgrading the skills of regulators and industry alike. Within the National Energy Policy, there are many appropriate training and education opportunities. Education was strongly endorsed by the President's National Energy Policy Development group. Acting through the governors offices, states are very effective conduits for the dissemination of energy education information. While the IOGCC favors the development of a comprehensive, long-term energy education plan, states are also supportive of immediate action on important concerns, such as energy prices, availability and conservation. Area of Interest No. 4--Resource Assessment and

  20. Exploring new scaling regimes for streaming potential and electroviscous effects in a nanocapillary with overlapping electric double layers.

    Science.gov (United States)

    Das, Siddhartha; Guha, Arnab; Mitra, Sushanta K

    2013-12-04

    In this paper, we unravel new scaling regimes for streaming potential and electroviscous effects in a nanocapillary with thick overlapping Electric Double Layers (EDLs). We observe that the streaming potential, for a given value of the capillary zeta (ζ) potential, varies with the EDL thickness and a dimensionless parameter R, quantifying the conduction current. Depending on the value of R, variation of the streaming potential with the EDL thickness demonstrates distinct scaling regimes: one can witness a Quadratic Regime where the streaming potential varies as the square of the EDL thickness, a Weak Regime where the streaming potential shows a weaker variation with the EDL thickness, and a Saturation Regime where the streaming potential ceases to vary with the EDL thickness. Effective viscosity, characterizing the electroviscous effect, obeys the variation of the streaming potential for smaller EDL thickness values; however, for larger EDL thickness the electroosmotic flow profile dictates the electroviscous effect, with insignificant contribution of the streaming potential.

  1. Impact of regulatory science on global public health.

    Science.gov (United States)

    Patel, Meghal; Miller, Margaret Ann

    2012-07-01

    Regulatory science plays a vital role in protecting and promoting global public health by providing the scientific basis for ensuring that food and medical products are safe, properly labeled, and effective. Regulatory science research was first developed for the determination of product safety in the early part of the 20th Century, and continues to support innovation of the processes needed for regulatory policy decisions. Historically, public health laws and regulations were enacted following public health tragedies, and often the research tools and techniques required to execute these laws lagged behind the public health needs. Throughout history, similar public health problems relating to food and pharmaceutical products have occurred in countries around the world, and have usually led to the development of equivalent solutions. For example, most countries require a demonstration of pharmaceutical safety and efficacy prior to marketing these products using approaches that are similar to those initiated in the United States. The globalization of food and medical products has created a shift in regulatory compliance such that gaps in food and medical product safety can generate international problems. Improvements in regulatory research can advance the regulatory paradigm toward a more preventative, proactive framework. These improvements will advance at a greater pace with international collaboration by providing additional resources and new perspectives for approaching and anticipating public health problems. The following is a review of how past public health disasters have shaped the current regulatory landscape, and where innovation can facilitate the shift from reactive policies to proactive policies.

  2. 75 FR 30453 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2010-06-01

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving..., Financial Industry Regulatory Authority, Inc. (``FINRA'') (f/k/a National Association of Securities Dealers... National Association of Securities Dealers, Inc., the Financial Industry Regulatory Authority, Inc., or...

  3. 75 FR 40000 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2010-07-13

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving Proposed Rule Change Relating to the Restated Certificate of Incorporation of Financial Industry Regulatory Authority, Inc. July 2, 2010. On May 21, 2010, Financial Industry Regulatory Authority, Inc....

  4. Towards a green urban economy? Unravelling urban sustainability transitions from a regime perspective

    NARCIS (Netherlands)

    Mans, U.; Meerow, S.

    2012-01-01

    The current debate about sustainability transitions has embraced the multi-level perspective as a useful methodological tool for assessing the dynamics that are at play between landscape, regime and niche. As a consequence, the thinking about socio-technical transitions has gradually shifted in

  5. Towards a green urban economy? Unravelling urban sustainability transitions from a regime perspective

    NARCIS (Netherlands)

    U. Mans; S. Meerow

    2012-01-01

    The current debate about sustainability transitions has embraced the multi-level perspective as a useful methodological tool for assessing the dynamics that are at play between landscape, regime and niche. As a consequence, the thinking about socio-technical transitions has gradually shifted in favo

  6. Quantifying the fire regime distributions for severity in Yosemite National Park, California, USA

    Science.gov (United States)

    Thode, Andrea E.; van Wagtendonk, Jan W.; Miller, Jay D.; Quinn, James F.

    2011-01-01

    This paper quantifies current fire severity distributions for 19 different fire-regime types in Yosemite National Park, California, USA. Landsat Thematic Mapper remote sensing data are used to map burn severity for 99 fires (cumulatively over 97 000 ha) that burned in Yosemite over a 20-year period. These maps are used to quantify the frequency distributions of fire severity by fire-regime type. A classification is created for the resultant distributions and they are discussed within the context of four vegetation zones: the foothill shrub and woodland zone; the lower montane forest zone; the upper montane forest zone and the subalpine forest zone. The severity distributions can form a building block from which to discuss current fire regimes across the Sierra Nevada in California. This work establishes a framework for comparing the effects of current fires on our landscapes with our notions of how fires historically burned, and how current fire severity distributions differ from our desired future conditions. As this process is refined, a new set of information will be available to researchers and land managers to help understand how fire regimes have changed from the past and how we might attempt to manage them in the future.

  7. Fish Springs National Wildlife Refuge water regime map

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Water regime map for Fish Springs National Wildlife Refuge. This map of water regimes on the refuge was created along with the National Vegetation Classification...

  8. Internationalization of regulatory requirements.

    Science.gov (United States)

    Juillet, Y

    2003-02-01

    The aim of harmonisation of medicines regulatory requirements is to allow the patient quicker access to new drugs and to avoid animal and human duplications. Harmonisation in the European Union (EU) is now completed, and has led to the submission of one dossier in one language study leading to European marketing authorizations, thanks in particular to efficacy guidelines published at the European level. With the benefit of the European experience since 1989, more than 40 guidelines have been harmonised amongst the EU, Japan and the USA through the International Conference on Harmonisation (ICH). ICH is a unique process gathering regulators and industry experts from the three regions. Its activity is built on expertise and trust. The Common Technical Document (CTD), an agreed common format for application in the three regions, is a logical follow-up to the ICH first phase harmonising the content of the dossier. The CTD final implementation in July 2003 will have considerable influence on the review process and on the exchange of information in the three regions.

  9. NGNP Project Regulatory Gap Analysis for Modular HTGRs

    Energy Technology Data Exchange (ETDEWEB)

    Wayne Moe

    2011-09-01

    The Next Generation Nuclear Plant (NGNP) Project Regulatory Gap Analysis (RGA) for High Temperature Gas-Cooled Reactors (HTGR) was conducted to evaluate existing regulatory requirements and guidance against the design characteristics specific to a generic modular HTGR. This final report presents results and identifies regulatory gaps concerning current Nuclear Regulatory Commission (NRC) licensing requirements that apply to the modular HTGR design concept. This report contains appendices that highlight important HTGR licensing issues that were found during the RGA study. The information contained in this report will be used to further efforts in reconciling HTGR-related gaps in the NRC licensing structure, which has to date largely focused on light water reactor technology.

  10. Experience in implementing regulatory requirements to protect against industrial sabotage

    Energy Technology Data Exchange (ETDEWEB)

    Knuth, D.F.

    1978-01-01

    Some of the problems and concerns in implementing the current regulatory requirements in physical protection of nuclear power plants are discussed. Until 1973, the Nuclear Regulatory Commission (NRC) was of the opinion that a determined group of professional saboteurs was beyond the scope of protection required. Since then regulatory changes have altered that concept; each successive regulatory change envisions a higher level of threat, and, hence, requires more provisions to protect the facilities. The author contends that, in some areas, NRC's decisions were hastily conceived with unrealistic implementation schedules. These decisions and regulations, if fully implemented, could be counterproductive to maintaining good security in a nuclear power plant, and are counterproductive to safety and operability of the plants.

  11. The discrete regime of flame propagation

    Science.gov (United States)

    Tang, Francois-David; Goroshin, Samuel; Higgins, Andrew

    The propagation of laminar dust flames in iron dust clouds was studied in a low-gravity envi-ronment on-board a parabolic flight aircraft. The elimination of buoyancy-induced convection and particle settling permitted measurements of fundamental combustion parameters such as the burning velocity and the flame quenching distance over a wide range of particle sizes and in different gaseous mixtures. The discrete regime of flame propagation was observed by substitut-ing nitrogen present in air with xenon, an inert gas with a significantly lower heat conductivity. Flame propagation in the discrete regime is controlled by the heat transfer between neighbor-ing particles, rather than by the particle burning rate used by traditional continuum models of heterogeneous flames. The propagation mechanism of discrete flames depends on the spa-tial distribution of particles, and thus such flames are strongly influenced by local fluctuations in the fuel concentration. Constant pressure laminar dust flames were observed inside 70 cm long, 5 cm diameter Pyrex tubes. Equally-spaced plate assemblies forming rectangular chan-nels were placed inside each tube to determine the quenching distance defined as the minimum channel width through which a flame can successfully propagate. High-speed video cameras were used to measure the flame speed and a fiber optic spectrometer was used to measure the flame temperature. Experimental results were compared with predictions obtained from a numerical model of a three-dimensional flame developed to capture both the discrete nature and the random distribution of particles in the flame. Though good qualitative agreement was obtained between model predictions and experimental observations, residual g-jitters and the short reduced-gravity periods prevented further investigations of propagation limits in the dis-crete regime. The full exploration of the discrete flame phenomenon would require high-quality, long duration reduced gravity environment

  12. REVIEW OF REGIME THEORY OF ALLUVIAL CHANNELS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    One of the most important problems in river engineering is to determine a stable cross section geomenry and slope for an alluvial channel. This has been the subject of considerable research for about a century and continues to be of great practical interest. Lgnoring plan geometry, an alluvi-al channel can adjust its slope, depth and width, to develop a dynamic stable condition in which it can transport a certain a-mount of water and sediment. The brief history of regime the-ory and its new development are reviewed in this paper.

  13. Electron acceleration in the bubble regime

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, Oliver

    2014-02-03

    The bubble regime of laser-wakefield acceleration has been studied over the recent years as an important alternative to classical accelerators. Several models and theories have been published, in particular a theory which provides scaling laws for acceleration parameters such as energy gain and acceleration length. This thesis deals with numerical simulations within the bubble regime, their comparison to these scaling laws and data obtained from experiments, as well as some specific phenomenona. With a comparison of the scaling laws with numerical results a parameter scan was able to show a large parameter space in which simulation and theory agree. An investigation of the limits of this parameter space revealed boundaries to other regimes, especially at very high (a{sub 0} > 100) and very low laser amplitudes (a{sub 0} < 4). Comparing simulation data with data from experiments concerning laser pulse development and electron energies, it was found that experimental results can be adequately reproduced using the Virtual-Laser-Plasma-Laboratory code. In collaboration with the Institut fuer Optik und Quantenelektronik at the Friedrich-Schiller University Jena synchrotron radiation emitted from the inside of the bubble was investigated. A simulation of the movement of the electrons inside the bubble together with time dependent histograms of the emitted radiation helped to prove that the majority of radiation created during a bubble acceleration originates from the inside of the bubble. This radiation can be used to diagnose the amplitude of oscillation of the trapped electrons. During a further study it was proven that the polarisation of synchrotron radiation from a bubble contains information about the exact oscillation direction. This oscillation was successfully controlled by using either a laser pulse with a tilted pulse front or an asymmetric laser pulse. First results of ongoing studies concerning injecting electrons into an existing bubble and a scheme called

  14. Efficiency of Rectification: Reversible vs. Irreversible Regimes

    Science.gov (United States)

    Sokolov, I. M.

    2002-11-01

    Both man-made locomotive devices and molecular motors use gears to transform a reciprocating motion into a directed one. One of the most common gears is a rectifier, a mechanically irreversible appliance. The maximal energetic efficiency of an isothermic gear is bounded by unity, as a consequence of the Second Law. However, approaching this ideal efficiency does not imply approaching reversibility. We discuss what properties of a rectifier mostly influence the transduction efficiency and show that an appliance which locks under backward force is just the one which can approach the ideal efficiency either in the reversible or in the irreversible regime.

  15. Muscle's Motion in an Overdamped Regime

    Institute of Scientific and Technical Information of China (English)

    AI Bao-Quan; WANG Xian-Ju; LIU Liang-Gang; M. Nakano; H. Matsuura

    2002-01-01

    Based on the stochastic inclined rods model proposed by H. Matsuura et al., we study the motion of actin myosin system in an overdamped regime. Our model is composed ofan inclined spring (rod), a myosin head and a myosin filament. The results of calculation show that the modelcan convert the random motion to one-directional motion, and the myosin head works as a resonator of random noise, which absorbs the energy through a stochastic resonance. The results show that the inclined rod and the intermolecular potential are very important for the system to move.

  16. Ultracold Molecules: Physics in the Quantum Regime

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, John [Harvard Univ., Cambridge, MA (United States). Dept. of Physics

    2014-11-17

    Our research encompasses approaches to the trapping of diatomic molecules at low temperature plus the cooling and detection of polyatomic molecules in the kelvin temperature regime. We have cooled and trapped CaF and/or CaH molecules, loaded directly from a molecular beam. As part of this work, we are continuing to develop an important trapping technique, optical loading from a buffer-gas beam. This method was invented in our lab. We are also studying cold polyatomic molecules and their interactions with cold atoms.

  17. Langmuir wave filamentation in the kinetic regime

    CERN Document Server

    Silantyev, Denis A; Rose, Harvey A

    2016-01-01

    Nonlinear Langmuir wave in the kinetic regime $k\\lambda_D\\gtrsim0.2$ has a transverse instability, where $k$ is the wavenumber and $\\lambda_D$ is the Debye length. The nonlinear stage of that instability development leads to the filamentation of Langmuir waves. Here we study the linear stage of transverse instability of both Bernstein-Greene-Kruskal (BGK) modes and dynamically prepared BGK-like initial conditions to find the same instability growth rate suggesting the universal mechanism for the kinetic saturation of stimulated Raman scatter in laser-plasma interaction experiments. Multidimensional Vlasov simulations results are compared to the theoretical predictions.

  18. Reconfigurable photoinduced metamaterials in the microwave regime

    CERN Document Server

    Rizza, Carlo; De Paulis, Francesco; Palange, Elia; Orlandi, Antonio; Columbo, Lorenzo; Prati, Franco

    2014-01-01

    We investigate optically reconfigurable dielectric metamaterials at gigahertz frequencies. More precisely, we study the microwave response of a subwavelength grating optically imprinted into a semiconductor slab. In the homogenized regime, we analytically evaluate the ordinary and extraordinary component of the effective permittivity tensor by taking into account the photo-carrier dynamics described by the ambipolar diffusion equation. We analyze the impact of semiconductor parameters on the gigahertz metamaterial response which turns out to be highly reconfigurable by varying the photogenerated grating and which can show a marked anisotropic behavior.

  19. Quality Regimes in Agro-Food Industries

    DEFF Research Database (Denmark)

    Staricco, Juan Ignacio; Ponte, Stefano

    2015-01-01

    In this article, we examine the transformative potential of changing quality regimes in agro-food industries through the analysis of whether Fair Trade wine in Argentina provides a meaningful economic alternative that goes beyond the impact it has on direct beneficiaries. The wine sector has a lo...... producing table wine for the domestic market, Fair Trade is actually further marginalizing them......., challenge and re-interpretation of different quality content. Through the lenses of a sector-adjusted version of regulation theory, we show that the Fair Trade wine sector does not substantially deviate from the conventional wine economy in Argentina. Instead of empowering the most vulnerable groups, those...

  20. Regulatory Accessibility and Social Influences on State Self-Control

    OpenAIRE

    vanDellen, Michelle R.; Hoyle, Rick H.

    2009-01-01

    The current work examined how social factors influence self-control. Current conceptions of state self-control treat it largely as a function of regulatory capacity. The authors propose that state self-control might also be influenced by social factors because of regulatory accessibility. Studies 1 through 4 provide evidence that individuals’ state self-control is influenced by the trait and state self-control of salient others such that thinking of others with good trait or state self-contro...

  1. Hard and Soft Excitation Regimes of Kerr Frequency Combs

    CERN Document Server

    Matsko, Andrey B; Ilchenko, Vladimir S; Seidel, David; Maleki, Lute

    2011-01-01

    We theoretically study the stability conditions and excitation regimes of hyper-parametric oscillation and Kerr frequency comb generation in continuously pumped nonlinear optical resonators possessing anomalous group velocity dispersion. We show that both hard and soft excitation regimes are possible in the resonators. Selection between the regimes is achieved via change in the parameters of the pumping light.

  2. Level-ARCH Short Rate Models with Regime Switching

    DEFF Research Database (Denmark)

    Christiansen, Charlotte

    This paper introduces regime switching volatility into level- ARCH models for the short rates of the US, the UK, and Germany. Once regime switching and level effects are included there are no gains from including ARCH effects. It is of secondary importance exactly how the regime switching...

  3. The relationship between void waves and flow regime transition

    Energy Technology Data Exchange (ETDEWEB)

    Lahey, R.T. Jr.; Drew, D.A.; Kalkach-Navarro, S.; Park, J.W.

    1992-12-31

    The results of an extensive experimental and analytical study on the relationship between void waves and flow regime transition are presented, in particular, the bubbly/slug flow regime transition. It is shown that void wave instability signals a flow regime transition.

  4. Low-frequency regime transitions and predictability of regimes in a barotropic model

    CERN Document Server

    Nadiga, B T

    2016-01-01

    Predictability of flow is examined in a barotropic vorticity model that admits low frequency regime transitions between zonal and dipolar states. Such transitions in the model were first studied by Bouchet and Simonnet (2009) and are reminiscent of regime change phenomena in the weather and climate systems wherein extreme and abrupt qualitative changes occur, seemingly randomly, after long periods of apparent stability. Mechanisms underlying regime transitions in the model are not well understood yet. From the point of view of atmospheric and oceanic dynamics, a novel aspect of the model is the lack of any source of background gradient of potential-vorticity such as topography or planetary gradient of rotation rate (e.g., as in Charney & DeVore '79). We consider perturbations that are embedded onto the system's chaotic attractor under the full nonlinear dynamics as bred vectors---nonlinear generalizations of the leading (backward) Lyapunov vector. We find that ensemble predictions that use bred vector per...

  5. The Legal Regime of the Right to Administrate Public Property

    Directory of Open Access Journals (Sweden)

    Vasilica Negruţ

    2014-05-01

    Full Text Available The traditional institutions for administrative law, public property and the public domain have been the subject of numerous specialized papers from the interwar period. After 1990, the two institutions were discussed in light of the new legislative rules. Within this article we propose to analyze, based on the distinction between the notions of public property and public domain, the legal regime of the right to administrate assets of public property. Is this a real right appropriate for public property or just a simple competence of administration and management of public domain assets? Analyzing and comparing the opinions, the arguments expressed by specialists and the current legislation in this area, we conclude that the administrative right is a real right suitable for public property.

  6. Small regulatory RNA and Legionella pneumophila

    Directory of Open Access Journals (Sweden)

    Sebastien P Faucher

    2011-05-01

    Full Text Available Legionella pneumophila is a gram-negative bacterial species that is ubiquitous in almost any aqueous environment. It is the agent of Legionnaires’ disease, an acute and often under-reported form of pneumonia. In mammals, L. pneumophila replicates inside macrophages within a modified vacuole. Many protein regulators have been identified that control virulence-related properties, including RpoS, LetA/LetS and PmrA/PmrB. In the past few years, the importance of regulation of virulence factors by small regulatory RNA has been increasingly appreciated. This is also the case in L. pneumophila where three sRNAs (RsmY, RsmZ and 6S RNA were recently shown to be important determinants of virulence regulation and 79 actively transcribed sRNAs were identified. In this review we describe current knowledge about sRNAs and their regulatory properties and how this relates to the known regulatory systems of L. pneumophila. We also provide a model for sRNA-mediated control of gene expression that serves as a framework for understanding the regulation of virulence-related properties of L. pneumophila.

  7. Food safety regulatory systems in Europe and China:A study of how co-regulation can improve regulatory effectiveness

    Institute of Scientific and Technical Information of China (English)

    Kevin Chen; WANG Xin-xin; SONG Hai-ying

    2015-01-01

    Food safety has received a great deal of attention in both developed and developing countries in recent years. In China, the numerous food scandals and scares that have struck over the past decade have spurred signiifcant food safety regulatory reform, which has been increasingly oriented towards the public-private partnership model adopted by the Europe Union’s (EU) food safety regulatory system. This paper analyzes the development of both the EU’s and China’s food safety regu-latory systems, identiifes the current chalenges for China and additionaly considers the role of public-private partnership. The success of co-regulation in the food regulatory system would bring signiifcant beneifts and opportunities for China. Finaly, this paper recommends additional measures like training and grants to improve the private’s sector effectiveness in co-regulating China’s food safety issues.

  8. Paving the Way for an Institutional Approach towards an Ethical Migration Regime

    Directory of Open Access Journals (Sweden)

    Johan Rochel

    2013-08-01

    Full Text Available In thinking about moral principles for an international regime on migration, international lawyers and political theorists wishing to provide practical guidance should adopt a specific methodological approach suitable for international institutions. This paper proposes a methodological tool entitled “normative reflexive dialogue” to support theorists in dealing with the current institutional realities while developing and justifying moral principles that international institutions should follow. After describing the basic features of this approach, which links legal analysis with moral reasoning, GATS Mode 4 will be used as an example of a methodological approach to generating some substantive moral principles for a migration regime.

  9. The Danish Regulatory Reform of Telecommunications

    DEFF Research Database (Denmark)

    Skouby, Knud Erik

    1998-01-01

    An overview of the liberalisation process and regulatory reform of telecommunications in Denmark......An overview of the liberalisation process and regulatory reform of telecommunications in Denmark...

  10. Variety of synchronous regimes in neuronal ensembles

    Science.gov (United States)

    Komarov, M. A.; Osipov, G. V.; Suykens, J. A. K.

    2008-09-01

    We consider a Hodgkin-Huxley-type model of oscillatory activity in neurons of the snail Helix pomatia. This model has a distinctive feature: It demonstrates multistability in oscillatory and silent modes that is typical for the thalamocortical neurons. A single neuron cell can demonstrate a variety of oscillatory activity: Regular and chaotic spiking and bursting behavior. We study collective phenomena in small and large arrays of nonidentical cells coupled by models of electrical and chemical synapses. Two single elements coupled by electrical coupling show different types of synchronous behavior, in particular in-phase and antiphase synchronous regimes. In an ensemble of three inhibitory synaptically coupled elements, the phenomenon of sequential synchronous dynamics is observed. We study the synchronization phenomena in the chain of nonidentical neurons at different oscillatory behavior coupled with electrical and chemical synapses. Various regimes of phase synchronization are observed: (i) Synchronous regular and chaotic spiking; (ii) synchronous regular and chaotic bursting; and (iii) synchronous regular and chaotic bursting with different numbers of spikes inside the bursts. We detect and study the effect of collective synchronous burst generation due to the cluster formation and the oscillatory death.

  11. Characterizing multistationarity regimes in biochemical reaction networks.

    Directory of Open Access Journals (Sweden)

    Irene Otero-Muras

    Full Text Available Switch like responses appear as common strategies in the regulation of cellular systems. Here we present a method to characterize bistable regimes in biochemical reaction networks that can be of use to both direct and reverse engineering of biological switches. In the design of a synthetic biological switch, it is important to study the capability for bistability of the underlying biochemical network structure. Chemical Reaction Network Theory (CRNT may help at this level to decide whether a given network has the capacity for multiple positive equilibria, based on their structural properties. However, in order to build a working switch, we also need to ensure that the bistability property is robust, by studying the conditions leading to the existence of two different steady states. In the reverse engineering of biological switches, knowledge collected about the bistable regimes of the underlying potential model structures can contribute at the model identification stage to a drastic reduction of the feasible region in the parameter space of search. In this work, we make use and extend previous results of the CRNT, aiming not only to discriminate whether a biochemical reaction network can exhibit multiple steady states, but also to determine the regions within the whole space of parameters capable of producing multistationarity. To that purpose we present and justify a condition on the parameters of biochemical networks for the appearance of multistationarity, and propose an efficient and reliable computational method to check its satisfaction through the parameter space.

  12. Pulse regime in formation of fractal fibers

    Science.gov (United States)

    Smirnov, B. M.

    2016-11-01

    The pulse regime of vaporization of a bulk metal located in a buffer gas is analyzed as a method of generation of metal atoms under the action of a plasma torch or a laser beam. Subsequently these atoms are transformed into solid nanoclusters, fractal aggregates and then into fractal fibers if the growth process proceeds in an external electric field. We are guided by metals in which transitions between s and d-electrons of their atoms are possible, since these metals are used as catalysts and filters in interaction with gas flows. The resistance of metal fractal structures to a gas flow is evaluated that allows one to find optimal parameters of a fractal structure for gas flow propagation through it. The thermal regime of interaction between a plasma pulse or a laser beam and a metal surface is analyzed. It is shown that the basic energy from an external source is consumed on a bulk metal heating, and the efficiency of atom evaporation from the metal surface, that is the ratio of energy fluxes for vaporization and heating, is 10-3-10-4 for transient metals under consideration. A typical energy flux ( 106 W/cm2), a typical surface temperature ( 3000 K), and a typical pulse duration ( 1 μs) provide a sufficient amount of evaporated atoms to generate fractal fibers such that each molecule of a gas flow collides with the skeleton of fractal fibers many times.

  13. Microgravity two-phase flow regime modeling

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D.; Best, F.R.; Faget, N.

    1987-01-01

    A flow pattern or flow regime is the characteristics spatial distribution of the phases of fluid in a duct. Since heat transfer and pressure drop are dependent on the characteristic distribution of the phases, it is necessary to describe flow patterns in an appropriate manner so that a hydrodynamic or heat transfer theory applicable to that pattern can be chosen. The objective of the present analysis is to create a flow regime map based on physical modeling of vapor/liquid interaction phenomena in a microgravity environment. In the present work, four basic flow patterns are defined: dispersed flow, stratified flow, slug flow, and annular flow. Fluid properties, liquid and vapor flow rates, and pipe size were chosen as the principal parameters. It is assumed that a transition from one flow pattern to another will occur when there is a change in the dominant force which controls that flow pattern. The forces considered in this modeling are surface tension force, both force, inertial force, friction, and turbulent fluctuations.

  14. XcisClique: analysis of regulatory bicliques

    Directory of Open Access Journals (Sweden)

    Grene Ruth

    2006-04-01

    Full Text Available Abstract Background Modeling of cis-elements or regulatory motifs in promoter (upstream regions of genes is a challenging computational problem. In this work, set of regulatory motifs simultaneously present in the promoters of a set of genes is modeled as a biclique in a suitably defined bipartite graph. A biologically meaningful co-occurrence of multiple cis-elements in a gene promoter is assessed by the combined analysis of genomic and gene expression data. Greater statistical significance is associated with a set of genes that shares a common set of regulatory motifs, while simultaneously exhibiting highly correlated gene expression under given experimental conditions. Methods XcisClique, the system developed in this work, is a comprehensive infrastructure that associates annotated genome and gene expression data, models known cis-elements as regular expressions, identifies maximal bicliques in a bipartite gene-motif graph; and ranks bicliques based on their computed statistical significance. Significance is a function of the probability of occurrence of those motifs in a biclique (a hypergeometric distribution, and on the new sum of absolute values statistic (SAV that uses Spearman correlations of gene expression vectors. SAV is a statistic well-suited for this purpose as described in the discussion. Results XcisClique identifies new motif and gene combinations that might indicate as yet unidentified involvement of sets of genes in biological functions and processes. It currently supports Arabidopsis thaliana and can be adapted to other organisms, assuming the existence of annotated genomic sequences, suitable gene expression data, and identified regulatory motifs. A subset of Xcis Clique functionalities, including the motif visualization component MotifSee, source code, and supplementary material are available at https://bioinformatics.cs.vt.edu/xcisclique/.

  15. Regulatory cross-cutting topics for fuel cycle facilities.

    Energy Technology Data Exchange (ETDEWEB)

    Denman, Matthew R.; Brown, Jason; Goldmann, Andrew Scott; Louie, David

    2013-10-01

    This report overviews crosscutting regulatory topics for nuclear fuel cycle facilities for use in the Fuel Cycle Research & Development Nuclear Fuel Cycle Evaluation and Screening study. In particular, the regulatory infrastructure and analysis capability is assessed for the following topical areas: Fire Regulations (i.e., how applicable are current Nuclear Regulatory Commission (NRC) and/or International Atomic Energy Agency (IAEA) fire regulations to advance fuel cycle facilities) Consequence Assessment (i.e., how applicable are current radionuclide transportation tools to support risk-informed regulations and Level 2 and/or 3 PRA) While not addressed in detail, the following regulatory topic is also discussed: Integrated Security, Safeguard and Safety Requirement (i.e., how applicable are current Nuclear Regulatory Commission (NRC) regulations to future fuel cycle facilities which will likely be required to balance the sometimes conflicting Material Accountability, Security, and Safety requirements.)

  16. Taking Stock of Regulatory Variation.

    Science.gov (United States)

    Maurano, Matthew T; Stamatoyannopoulos, John A

    2015-07-29

    Three recent studies measure individual variation in regulatory DNA accessibility. What do they tell us about the prospects of assessing variation in single cells and across populations? Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Distinct transport regimes for two elastically coupled molecular motors.

    Science.gov (United States)

    Berger, Florian; Keller, Corina; Klumpp, Stefan; Lipowsky, Reinhard

    2012-05-18

    Cooperative cargo transport by two molecular motors involves an elastic motor-motor coupling, which can reduce the motors' velocity and/or enhance their unbinding from the filament. We show theoretically that these interference effects lead, in general, to four distinct transport regimes. In addition to a weak coupling regime, kinesin and dynein motors are found to exhibit a strong coupling and an enhanced unbinding regime, whereas myosin motors are predicted to attain a reduced velocity regime. All of these regimes, which we derive by explicit calculations and general time scale arguments, can be explored experimentally by varying the elastic coupling strength.

  18. Essence and Prospect of International Export Control Regimes

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ International export control regimes are referring to the regimes and systems concerning limitation of export and transference of military-use and dual-use items and related parts as well as technologies. In the past couple of years, the control regimes have shown a strengthening posture. In addition, a new global export control regime is brewing. Hence export control has caught the attention of the international community, and particularly of the circles of armament control and commerce. The author would like to make some analyses of the posture and then try to predict the trend of international export control regimes.

  19. Regulatory facility guide for Ohio

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S.S.; Bock, R.E.; Francis, M.W.; Gove, R.M.; Johnson, P.E.; Kovac, F.M.; Mynatt, J.O. [Oak Ridge National Lab., TN (United States); Rymer, A.C. [Transportation Consulting Services, Knoxville, TN (United States)

    1994-02-28

    The Regulatory Facility Guide (RFG) has been developed for the DOE and contractor facilities located in the state of Ohio. It provides detailed compilations of international, federal, and state transportation-related regulations applicable to shipments originating at destined to Ohio facilities. This RFG was developed as an additional resource tool for use both by traffic managers who must ensure that transportation operations are in full compliance with all applicable regulatory requirements and by oversight personnel who must verify compliance activities.

  20. Electronic Commerce Removing Regulatory Impediments

    Science.gov (United States)

    1992-05-01

    AD-A252 691 ELECTRONIC COMMERCE Removing Regulatory Impediments ~DuiG A% ELECTE I JUL1 8 1992 0 C D Daniel J. Drake John A. Ciucci ... - ""N ST AT KE...Management Institute 6400 Goldsboro Road Bethesda, Maryland 20817-5886 92 LMI Executive Summary ELECTRONIC COMMERCE : REMOVING REGULATORY IMPEDIMENTS... Electronic Commerce techniques, such as electronic mail and electronic data interchange (EDI), enable Government agencies to conduct business without the

  1. Poverty Alleviation and Environmental Sustainability through Improved Regimes of Technology Transfer

    Directory of Open Access Journals (Sweden)

    Klaus Bosselmann

    2006-06-01

    Full Text Available To achieve the Millennium Development Goals, international technology transfer can play a major role for poverty alleviation and environmental sustainability. At present, there are economic, social and legal (rather than technical barriers preventing the transfer of environmentally sound technology (EST from a wider use in international regimes. Removing these barriers requires greater political and regulatory efforts both domestically and internationally. To enable EST transfer, developed States need to improve domestic market conditions such as removal of negative subsidies and barriers to foreign investment, targeted fiscal incentives and law reforms favouring sustainable production and use of energy. There is no realistic perspective for international EST transfer as long as it is disadvantaged domestically. A coherent EST transfer regime is only possible through greater governmental intervention at the national and international level, including environmental regulations, national systems of innovation, and creating an enabling environment for EST. Such intervention should include effective public-private partnerships, both within and between States. Partnerships, if guided by law, could ensure EST innovation more efficiently than purely State-driven or market-driven EST transfers. In search for a model, the EST transfer regime under the Vienna Ozone Layer Convention and the Montreal Protocol deserves recognition. For example, the clean development mechanism under the Kyoto Protocol allows for considerable scope for EST transfer. The potential of EST transfer for climate change and for meeting the Millennium Development Goals has yet to be realized.

  2. Cointegration and causal linkages in fertilizer markets across different regimes

    Science.gov (United States)

    Lahmiri, Salim

    2017-04-01

    Cointegration and causal linkages among five different fertilizer markets are investigated during low and high market regimes. The database includes prices of rock phosphate (RP), triple super phosphate (TSP), diammonium phosphate (DAP), urea, and potassium chloride (PC). It is found that fertilizer markets are closely linked to each other during low and high regimes; and, particularly during high regime (after 2007 international financial crisis). In addition, there is no evidence of bidirectional linear relationship between markets during low and high regime time periods. Furthermore, all significant linkages are only unidirectional. Moreover, some causality effects have emerged during high regime. Finally, the effect of an impulse during high regime time period persists longer and is stronger than the effect of an impulse during low regime time period (before 2007 international financial crisis).

  3. Modern fire regime resembles historical fire regime in a ponderosa pine forest on Native American land

    Science.gov (United States)

    Amanda B. Stan; Peter Z. Fule; Kathryn B. Ireland; Jamie S. Sanderlin

    2014-01-01

    Forests on tribal lands in the western United States have seen the return of low-intensity surface fires for several decades longer than forests on non-tribal lands. We examined the surface fire regime in a ponderosa pinedominated (Pinus ponderosa) forest on the Hualapai tribal lands in the south-western United States. Using fire-scarred trees, we inferred temporal (...

  4. Protection of people and environment from radiation risk through good regulatory practice

    Science.gov (United States)

    Jais, Azlina Mohammad; Hassan, Najwa

    2017-01-01

    The term "good regulatory practice" has seen growing frequency of usage worldwide, especially since the 2011 Fukushima nuclear incident. However, the term appears quite ambiguous as it may mean differently to different people. This leads us to the first important question: what does "good regulatory practice" actually mean? When used in conjunction with the Fukushima incident, do we imply that there is an absence of "good regulatory practice" in the Japanese' Nuclear and Industry Safety Agency (NISA)? This is quite troubling. It is clear that the term should be defined formally so that our understanding of "good regulatory practice" can be standardized. There is still another important question beyond agreeing on what "good regulatory practice" is: is "good regulatory practice" specific to a region, or is it global? And is it applicable only to nuclear regulators, or to all types of regulators per se? This paper aims to deliberate on the above mentioned questions. Specifically, we hope to discuss the "good regulatory practice" for atomic energy activities in order to protect the people and the environment from radiation risk of such activities. By understanding what "good regulatory practice" truly means, a newcomer country such as Malaysia can quickly learn and adopt these practices so as to assure a competent national nuclear regulatory authority who will be responsible in ensuring the safety, security and safeguards of peaceful atomic energy activities in the country including nuclear liability. In understanding this concept, a holistic approach will be taken by looking into example of advanced and newcomer countries of various nuclear regulatory authorities all around the world. Then the paper will focus on the challenges that the current nuclear regulatory authority in Malaysia which is Atomic Energy Licensing Board has, its challenges to follow the concept of "good regulatory practice" and its ways to overcome it. This study explore the initiatives could be

  5. Stepping back from the property line: a perspective from regulatory theory.

    Science.gov (United States)

    Dent, Chris

    2013-12-01

    There are multiple populations affected by issues associated with the excision and use of human tissue, each with different interests. There are also multiple subject matters for regulation; multiple regulatory goals that inform the system; and multiple strategies that may contribute to the attainment of those goals. This article outlines a range of regulatory mechanisms and suggests that a property regime is only one method of regulation in this area. Others may need to be considered to take account of the interests of all who may be affected,

  6. Filling regulatory gaps in high seas fisheries: discrete high seas fish stocks, deep-sea fisheries and vulnerable marine ecosystems

    NARCIS (Netherlands)

    Takei, Y.

    2008-01-01

    The present study examines the legal regime of high seas fisheries with a view to identifying regulatory gaps. The main research questions are as follows: 1. What general principles are applicable to high seas fisheries?; 2. What implications do these general principles have for new challenges in th

  7. Ecosystem carbon storage capacity as affected by disturbance regimes: A general theoretical model

    Energy Technology Data Exchange (ETDEWEB)

    Weng, Ensheng [University of Oklahoma, Norman; Luo, Yiqi [University of Oklahoma; Wang, Weile [NASA Ames Research Center; Wang, Han [University of Oklahoma, Norman; Hayes, Daniel J [ORNL; McGuire, A. David [University of Alaska; Hastings, Alan [University of California, Davis; Schimel, David [NEON Inc.

    2012-01-01

    Disturbances have been recognized as a key factor shaping terrestrial ecosystem states and dynamics. A general model that quantitatively describes the relationship between carbon storage and disturbance regime is critical for better understanding large scale terrestrial ecosystem carbon dynamics. We developed a model (REGIME) to quantify ecosystem carbon storage capacities (E[x]) under varying disturbance regimes with an analytical solution E[x] = U {center_dot} {tau}{sub E} {center_dot} {lambda}{lambda} + s {tau} 1, where U is ecosystem carbon influx, {tau}{sub E} is ecosystem carbon residence time, and {tau}{sub 1} is the residence time of the carbon pool affected by disturbances (biomass pool in this study). The disturbance regime is characterized by the mean disturbance interval ({lambda}) and the mean disturbance severity (s). It is a Michaelis-Menten-type equation illustrating the saturation of carbon content with mean disturbance interval. This model analytically integrates the deterministic ecosystem carbon processes with stochastic disturbance events to reveal a general pattern of terrestrial carbon dynamics at large scales. The model allows us to get a sense of the sensitivity of ecosystems to future environmental changes just by a few calculations. According to the REGIME model, for example, approximately 1.8 Pg C will be lost in the high-latitude regions of North America (>45{sup o} N) if fire disturbance intensity increases around 5.7 time the current intensity to the end of the twenty-first century, which will require around 12% increases in net primary productivity (NPP) to maintain stable carbon stocks. If the residence time decreased 10% at the same time additional 12.5% increases in NPP are required to keep current C stocks. The REGIME model also lays the foundation for analytically modeling the interactions between deterministic biogeochemical processes and stochastic disturbance events.

  8. Institutional design and regime effectiveness in transboundary river management – the Elbe water quality regime

    Directory of Open Access Journals (Sweden)

    I. Dombrowsky

    2007-06-01

    Full Text Available The literature on transboundary river management suggests that institutions play an important role in bringing cooperation about. However, the knowledge on how they should be designed in order to do so remains limited. One way to learn more about adequate institutional design is to assess the effectiveness of existing regimes, and to trace the causal relationships leading to the respective outcomes. In order to gain further insights into the relationship of institutional design and regime effectiveness, this paper presents a study on the water quality regime of the International Commission for the Protection of the Elbe (ICPE. The analysis is based on a review of pertinent documents and ten qualitative interviews with Czech and German Commission members and NGO representatives. Particular emphasis has been put on determining the ICPE's specific contribution and the no-regime counterfactual as well as on the perceived expedience of the institutional arrangements. The study shows that overall due to external as well as internal institutional factors the ICPE proved relatively successful, and as such it also provides insights into how institutions matter: The commission served as platform for joint problem solving by identifying priorities for action. These international obligations increased the power of national administrations and their access to funds. At the same time, the Commission's reporting to the public served as an enforcement mechanism. However, the ICPE's contribution towards achieving the various goals varied significantly between the different areas of activity. It was high where the main responsibility for action was with the public authorities, such as in the area of wastewater treatment and the establishment of an international alarm plan and model. It was practically non existent in the reduction of non-point pollution from agriculture, where the success depended on the behavior of individual private actors (farmers. From a

  9. Regulatory research / Pesquisa regulatória

    Directory of Open Access Journals (Sweden)

    Altair Souza de Assis

    2013-05-01

    Full Text Available We present in this paper the concept, importance, and scope of research into the regulatory framework of regulation and legislation, with a particular focus on legislation related to legal metrology. This study also describes a comparative analysis of the various forms of regulation and the associated regulatory research, with the ultimate goal of better defi ning the concept and to validate the need to have research groups within a country’s regulatory bodies. Based on this work, we conclude that regulatory research is a key factor in the success of any regulatory body’s activities. Such research helps to avoid the creation of absurd or impractical regulatory barriers to a country’s technological development, or worse, to permit “orphans,” that is, technologies that are outside regulatory control, as is currently the case. Indeed, for a country to have a robust technological infrastructure, especially if it is still a developing country, strong and competent regulatory control is essential. However, this must be balanced by an atmosphere that fosters continuous and consistent technological innovation, and such development must also be self-sustainable from economic, social, and environmental viewpoints. ------------------------------------------------ Apresenta-se neste trabalho o conceito, a importância e a abrangência da pesquisa regulatória no âmbito da regulação e da regulamentação, com foco particular na regulamentação relacionada à metrologia legal. Faz-se também uma análise comparativa entre as várias formas de regular e regulamentar, e as suas pesquisas regulatórias afi ns, tendo como meta principal situar melhor o conceito e validar a necessidade de se fazer pesquisa nos órgãos e agências regulatórias do país. Com base neste trabalho, concluímos que a pesquisa regulatória é um fator chave para o sucesso de qualquer plano de ação de regulação para os agentes regulatórios do país. Ela ajuda a

  10. Mobile Networks: Visualizing the Global Refugee Regime

    Directory of Open Access Journals (Sweden)

    Bennett Gabriel Sherry

    2015-08-01

    Full Text Available This article identifies conceptual issues surrounding the visualization of refugee movement in relation to state borders. It argues that social-network-analysis software provides a tool for the creation of visualizations of human movement that are removed from geolocation. Such a method disassociates forced migration from preconceived notions about the importance of geographical proximity and the fixity of state borders. This article provides some brief examples of ways that these methods might be utilized to graph and visualize aspects of the global refugee regime. The global-scale, transnational conceptualization and new visualizations show networks of movement centered on new inter-state communities and highlights the role of non-state actors.

  11. The Great Lakes' regional climate regimes

    Science.gov (United States)

    Sugiyama, Noriyuki

    For the last couple of decades, the Great Lakes have undergone rapid surface warming. In particular, the magnitude of the summer surface-warming trends of the Great Lakes have been much greater than those of surrounding land (Austin and Colman, 2007). Among the Great Lakes, the deepest Lake Superior exhibited the strongest warming trend in its annual, as well as summer surface water temperature. We find that many aspects of this behavior can be explained in terms of the tendency of deep lakes to exhibit multiple regimes characterized, under the same seasonally varying forcing, by the warmer and colder seasonal cycles exhibiting different amounts of wintertime lake-ice cover and corresponding changes in the summertime lake-surface temperatures. In this thesis, we address the problem of the Great Lakes' warming using one-dimensional lake modeling to interpret diverse observations of the recent lake behavior. (Abstract shortened by ProQuest.).

  12. Quantum Error Correction in the Zeno Regime

    CERN Document Server

    Erez, N; Reznik, B; Vaidman, L; Erez, Noam; Aharonov, Yakir; Reznik, Benni; Vaidman, Lev

    2003-01-01

    In order to reduce errors, error correction codes (ECCs) need to be implemented fast. They can correct the errors corresponding to the first few orders in the Taylor expansion of the Hamiltonian of the interaction with the environment. If implemented fast enough, the zeroth order error predominates and the dominant effect is of error prevention by measurement (Zeno Effect) rather than correction. In this ``Zeno Regime'', codes with less redundancy are sufficient for protection. We describe such a simple scheme, which uses two ``noiseless'' qubits to protect a large number, $n$, of information qubits from noise from the environment. The ``noisless qubits'' can be realized by treating them as logical qubits to be encoded by one of the previously introduced encoding schemes.

  13. Regime shifts in models of dryland vegetation

    CERN Document Server

    Zelnik, Yuval R; Yizhaq, Hezi; Bel, Golan; Meron, Ehud

    2013-01-01

    Drylands are pattern-forming systems showing self-organized vegetation patchiness, multiplicity of stable states and fronts separating domains of alternative stable states. Pattern dynamics, induced by droughts or disturbances, can result in desertification shifts from patterned vegetation to bare soil. Pattern-formation theory suggests various scenarios for such dynamics; an abrupt global shift involving a fast collapse to bare soil, a gradual global shift involving the expansion and coalescence of bare-soil domains, and an incipient shift to a hybrid state consisting of stationary bare-soil domains in an otherwise periodic pattern. Using models of dryland vegetation we address the question which of these scenarios can be realized. We found that the models can be split into two groups: models that exhibit multiplicity of periodic-pattern and bare-soil states, and models that exhibit, in addition, multiplicity of hybrid states. Furthermore, in all models we could not identify parameter regimes in which bare-s...

  14. Dynamic Recrystallization: The Dynamic Deformation Regime

    Science.gov (United States)

    Murr, L. E.; Pizaña, C.

    2007-11-01

    Severe plastic deformation (PD), especially involving high strain rates (>103 s 1), occurs through solid-state flow, which is accommodated by dynamic recrystallization (DRX), either in a continuous or discontinuous mode. This flow can be localized in shear instability zones (or adiabatic shear bands (ASBs)) with dimensions smaller than 5 μ, or can include large volumes with flow zone dimensions exceeding centimeters. This article illustrates these microstructural features using optical and electron metallography to examine a host of dynamic deformation examples: shaped charge jet formation, high-velocity and hypervelocity impact crater formation, rod penetration into thick targets (which includes rod and target DRX flow and mixing), large projectile-induced target plug formation and failure, explosive welding, and friction-stir welding and processing. The DRX is shown to be a universal mechanism that accommodates solid-state flow in extreme (or severe) PD regimes.

  15. Spin current

    CERN Document Server

    Valenzuela, Sergio O; Saitoh, Eiji; Kimura, Takashi

    2012-01-01

    In a new branch of physics and technology called spin-electronics or spintronics, the flow of electrical charge (usual current) as well as the flow of electron spin, the so-called 'spin current', are manipulated and controlled together. This book provides an introduction and guide to the new physics and application of spin current.

  16. The Quantum-Gravity Regime under Microgravity

    Science.gov (United States)

    Laemmerzahl, Claus; Könemann, Thorben

    Gravity is the weakest of the four known interactions. Accordingly, one needs either huge masses to explore this interaction or a long time to accumulate its small influence. The latter is possible only under microgravity conditions. In this contribution we would like to focus on three issues related to basic problems in the quantum-gravity regime: (i) Search for fundamental decoherence: Decoherence describes the transition from the quantum world to the classical regime. There are many technical sources of decoherence but the question is whether there is a fundamental mechanism for such a decoherence which would be a solution for the measurement problem in quantum mechanics. Here we describe the estimates on such a fundamental decoherence from experiments with Bose-Einstein condensates in microgravity. (ii) Search for possible self-gravity effects: Self gravity has been proposed e.g. by Penrose to resolve the measurement problem. Self gravitating systems are also give Bose stars which are a model for the pyhsics around black holes or for dark matter. Here we would like to describe effects of self gravity in Bose-Einstein condensates. We calculate stationary spherically symmetric states and discuss the possibility to measure such effects related to self gravity. (iii) Test of the semiclassical Einstein equations. Since General Relativity and quantum theory appear to be incompatible, it has been discussed whether the semiclassical Einstein equations might be valid. Here we would like to discuss a proposal made by Peres and Lindner to use Bose-Einstein condensates for a true quantum test of these semiclassical Einstein equations from which one can decide whether such an ansatz is valid or not.

  17. Cavity Optomechanics in the Quantum Regime

    Science.gov (United States)

    Botter, Thierry Claude Marc

    An exciting scientific goal, common to many fields of research, is the development of ever-larger physical systems operating in the quantum regime. Relevant to this dissertation is the objective of preparing and observing a mechanical object in its motional quantum ground state. In order to sense the object's zero-point motion, the probe itself must have quantum-limited sensitivity. Cavity optomechanics, the interactions between light and a mechanical object inside an optical cavity, provides an elegant means to achieve the quantum regime. In this dissertation, I provide context to the successful cavity-based optical detection of the quantum-ground-state motion of atoms-based mechanical elements; mechanical elements, consisting of the collective center-of-mass (CM) motion of ultracold atomic ensembles and prepared inside a high-finesse Fabry-Perot cavity, were dispersively probed with an average intracavity photon number as small as 0.1. I first show that cavity optomechanics emerges from the theory of cavity quantum electrodynamics when one takes into account the CM motion of one or many atoms within the cavity, and provide a simple theoretical framework to model optomechanical interactions. I then outline details regarding the apparatus and the experimental methods employed, highlighting certain fundamental aspects of optical detection along the way. Finally, I describe background information, both theoretical and experimental, to two published results on quantum cavity optomechanics that form the backbone of this dissertation. The first publication shows the observation of zero-point collective motion of several thousand atoms and quantum-limited measurement backaction on that observed motion. The second publication demonstrates that an array of near-ground-state collective atomic oscillators can be simultaneously prepared and probed, and that the motional state of one oscillator can be selectively addressed while preserving the near-zero-point motion of

  18. Comparison of natural and forced amplification regimes in plasma-based soft-x-ray lasers seeded by high-order harmonics

    Energy Technology Data Exchange (ETDEWEB)

    Oliva, Eduardo; Zeitoun, Philippe; Lambert, Guillaume; Sebban, Stephane [Laboratoire d' Optique Appliquee, ENSTA ParisTech, Ecole Polytechnique Paris Tech, CNRS, UMR 7639, F-91761 Palaiseau Cedex (France); Fajardo, Marta [GoLP, Instituto de Plasmas e Fusao Nuclear, Laboratorio Associado, Instituto Superior Tecnico, Lisbon (Portugal); Ros, David [Laboratoire de Physique des Gaz et Plasmas, Universite Paris Sud 11, Orsay (France); Velarde, Pedro [Instituto de Fusion Nuclear, Universidad Politecnica de Madrid, Madrid (Spain)

    2011-07-15

    The amplification of high-order harmonics (HOH) in a plasma-based amplifier is a multiscale, temporal phenomenon that couples plasma hydrodynamics, atomic processes, and HOH electromagnetic fields. We use a one-dimensional, time-dependent Maxwell-Bloch code to compare the natural amplification regime and another regime where plasma polarization is constantly forced by the HOH. In this regime, a 10-MW (i.e., 100 times higher than current seeded soft x-ray laser power), 1.5-{mu}J, 140-fs pulse free from the parasitic temporal structures appearing on the natural amplification regime can be obtained.

  19. The role of the media in establishing international security regimes

    Directory of Open Access Journals (Sweden)

    Chanan Naveh

    2005-04-01

    Full Text Available This article focuses primarily on the media's impact on international security regimes. It explores the ways in which the media affect the lifecycles of international regimes, from the time they are first conceived of, through their establishment, consolidation and stabilization, up until their ultimate demise. Although this paper highlights the media's role in the evolution of security regimes, it is clear that, regardless of the regime in question, media play a role throughout the lifecycle of all international regimes, whatever their character. In order to analyze the relationships of the media with security regimes in general, and specifically their contribution to each stage in their development, the article utilizes methodologies from the field of communication studies. It examines the media's agenda, "news values" and various functions, and their ability to mobilize public support for the particular issue of the regime. To date, most studies have explored the interaction between media communication patterns and global developments at the state level, or in relation to the formulation of foreign policy, while largely ignoring the international dimension of the relationship. This article attempts to remedy this situation, and the relevant processes are analysed in a case study of the anti-Iraq international security regime. It should be noted that although the paper focuses on the specific anti-Iraqi regime, it is part of a more general Anti-Rogue actors regime which includes the war against global terrorism. The study of the development of the anti-Iraq press-security regime teaches us that during international crises the media mobilize and unanimously support the regime fighting the "bad guys." But, when the regime develops and enters disputed turfs and begins to lose its legitimacy, media support diminishes, and the media may even develop into an opposing force and may join the actors fighting against this regime. Moreover, the study of

  20. Regulatory and Permitting Issues

    Energy Technology Data Exchange (ETDEWEB)

    Larry Myer

    2005-12-01

    As part of the West Coast Regional Carbon Sequestration Partnership (WESTCARB), Terralog Technologies USA, Inc., reviewed current state and federal regulations related to carbon dioxide capture and storage within geologic formations and enhanced carbon uptake in terrestrial ecosystems. We have evaluated and summarized the current and possible future permitting requirements for the six states that comprise the West Coast Regional Partnership. Four options exist for CO{sub 2} injection into appropriate geologic formations, including storage in: (1) oil and gas reservoirs, (2) saline formations, (3) unmineable coal beds, and (4) salt caverns. Terrestrial CO{sub 2} sequestration involves improved carbon conservation management (e.g. reduction of deforestation), carbon substitution (e.g., substitution for fossil fuel-based products, energy conservation through urban forestry, biomass for energy generation), and improved carbon storage management (e.g., expanding the storage of carbon in forest ecosystems). The primary terrestrial options for the West Coast Region include: (1) reforestation of under-producing lands (including streamside forest restoration), (2) improved forest management, (3) forest protection and conservation, and (4) fuel treatments for the reduction of risk of uncharacteristically severe fires (potentially with associated biomass energy generation). The permits and/or contracts required for any land-use changes/disturbances and biomass energy generation that may occur as part of WESTCARB's activities have been summarized for each state.

  1. Modeling genomic regulatory networks with big data.

    Science.gov (United States)

    Bolouri, Hamid

    2014-05-01

    High-throughput sequencing, large-scale data generation projects, and web-based cloud computing are changing how computational biology is performed, who performs it, and what biological insights it can deliver. I review here the latest developments in available data, methods, and software, focusing on the modeling and analysis of the gene regulatory interactions in cells. Three key findings are: (i) although sophisticated computational resources are increasingly available to bench biologists, tailored ongoing education is necessary to avoid the erroneous use of these resources. (ii) Current models of the regulation of gene expression are far too simplistic and need updating. (iii) Integrative computational analysis of large-scale datasets is becoming a fundamental component of molecular biology. I discuss current and near-term opportunities and challenges related to these three points.

  2. 77 FR 46339 - Chrysanthemum White Rust Regulatory Status and Restrictions

    Science.gov (United States)

    2012-08-03

    ..., destruction, treatment, or other sanitation measures called for in our National Management Plan. The... reevaluating our current regulatory strategy in order to improve the effectiveness and economic efficiency of...-Goldner, National Program Manager, Emergency and Domestic Programs, PPQ, APHIS, 4700 River Road Unit 160...

  3. Perspectives on an alternative career path in regulatory science

    OpenAIRE

    Fields, F. Owen

    2013-01-01

    Perspectives are provided on an alternative career path in regulatory science for those currently involved in basic biology research. This path is compared and contrasted with basic research, and factors to be examined if one is considering such a path are discussed.

  4. Perspectives on an alternative career path in regulatory science.

    Science.gov (United States)

    Fields, F Owen

    2013-07-01

    Perspectives are provided on an alternative career path in regulatory science for those currently involved in basic biology research. This path is compared and contrasted with basic research, and factors to be examined if one is considering such a path are discussed.

  5. Determinants of Effective Information Transfer in International Regulatory Standards Adoption

    Science.gov (United States)

    Popescu, Denisa

    2010-01-01

    The role of international regulatory standards within the current global environment has become of the most importance. The age of the global system and free market capitalism carried us into the unprecedented age of regulations, and standard setting. Regulations are now becoming the emerging mode of global governance. This study focuses on…

  6. Implications of climate change on flow regime affecting Atlantic salmon

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The UKCIP02 climate change scenarios (2070–2100 suggest that the UK climate will become warmer (an overall increase of 2.5–3°C, with temperature increases being greater in the summer and autumn than in the spring and winter seasons. In terms of precipitation, winters are expected to become wetter and summers drier throughout the UK. The effect of changes in the future climate on flow regimes are investigated for the Atlantic salmon, Salmo salar, in a case study in an upland UK river. Using a hydraulic modelling approach, flows simulated across the catchment are assessed in terms of hydraulic characteristics (discharge per metre width, flow depths, flow velocities and Froude number. These, compared with suitable characteristics published in the literature for various life stages of Atlantic salmon, enable assessment of habitat suitability. Climate change factors have been applied to meteorological observations in the Eden catchment (north-west England and effects on the flow regime have been investigated using the SHETRAN hydrological modelling system. High flows are predicted to increase by up to 1.5%; yet, a greater impact is predicted from decreasing low flows (e.g. a Q95 at the outlet of the study catchment may decrease to a Q85 flow. Reliability, Resilience and Vulnerability (RRV analysis provides a statistical indication of the extent and effect of such changes on flows. Results show that future climate will decrease the percentage time the ideal minimum physical habitat requirements will be met. In the case of suitable flow depth for spawning activity at the outlet of the catchment, the percentage time may decrease from 100% under current conditions to 94% in the future. Such changes will have implications for the species under the Habitats Directive and for catchment ecological flow management strategies.

  7. Managing the human component of fire regimes: lessons from Africa.

    Science.gov (United States)

    Archibald, Sally

    2016-06-05

    Human impacts on fire regimes accumulated slowly with the evolution of modern humans able to ignite fires and manipulate landscapes. Today, myriad voices aim to influence fire in grassy ecosystems to different ends, and this is complicated by a colonial past focused on suppressing fire and preventing human ignitions. Here, I review available evidence on the impacts of people on various fire characteristics such as the number and size of fires, fire intensity, fire frequency and seasonality of fire in African grassy ecosystems, with the intention of focusing the debate and identifying areas of uncertainty. Humans alter seasonal patterns of fire in grassy systems but tend to decrease total fire emissions: livestock have replaced fire as the dominant consumer in many parts of Africa, and fragmented landscapes reduce area burned. Humans alter the season and time of day when fires occur, with important implications for fire intensity, tree-grass dynamics and greenhouse gas (GHG) emissions. Late season fires are more common when fire is banned or illegal: these later fires are far more intense but emit fewer GHGs. The types of fires which preserve human livelihoods and biodiversity are not always aligned with the goal of reducing GHG concentrations. Current fire management challenges therefore involve balancing the needs of a large rural population against national and global perspectives on the desirability of different types of fire, but this cannot happen unless the interests of all parties are equally represented. In the future, Africa is expected to urbanize and land use to intensify, which will imply different trajectories for the continent's fire regimes.This article is part of the themed issue 'The interaction of fire and mankind.

  8. Gene regulatory network inference using out of equilibrium statistical mechanics.

    Science.gov (United States)

    Benecke, Arndt

    2008-08-01

    Spatiotemporal control of gene expression is fundamental to multicellular life. Despite prodigious efforts, the encoding of gene expression regulation in eukaryotes is not understood. Gene expression analyses nourish the hope to reverse engineer effector-target gene networks using inference techniques. Inference from noisy and circumstantial data relies on using robust models with few parameters for the underlying mechanisms. However, a systematic path to gene regulatory network reverse engineering from functional genomics data is still impeded by fundamental problems. Recently, Johannes Berg from the Theoretical Physics Institute of Cologne University has made two remarkable contributions that significantly advance the gene regulatory network inference problem. Berg, who uses gene expression data from yeast, has demonstrated a nonequilibrium regime for mRNA concentration dynamics and was able to map the gene regulatory process upon simple stochastic systems driven out of equilibrium. The impact of his demonstration is twofold, affecting both the understanding of the operational constraints under which transcription occurs and the capacity to extract relevant information from highly time-resolved expression data. Berg has used his observation to predict target genes of selected transcription factors, and thereby, in principle, demonstrated applicability of his out of equilibrium statistical mechanics approach to the gene network inference problem.

  9. Adolescent threat-related interpretive bias and its modification: the moderating role of regulatory control

    NARCIS (Netherlands)

    Salemink, E.; Wiers, R.W.

    2012-01-01

    Dual process models describe psychopathology as the consequence of an imbalance between a fast, impulsive system and a regulatory control system and have recently been applied to anxiety disorders. The aim of the current study was to specifically examine the role of a regulatory control system in re

  10. 78 FR 62728 - Self Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-10-22

    ... responsibilities. Therefore, the Series 14 measures the knowledge and skills related to the position of a... provide direction to Participant Firms designing their supervisory systems and reinforce the importance of... regulatory, compliance and sales practice matters in the industry. Currently, there are two Regulatory...

  11. Impact of Safety-Related Regulatory Action on Clinical Practice A Systematic Review

    NARCIS (Netherlands)

    Piening, Sigrid; Haaijer-Ruskamp, Flora M.; de Vries, Jonie T. N.; van der Elst, Menno E.; de Graeff, Pieter A.; Straus, Sabine M. J. M.; Mol, Peter G. M.

    2012-01-01

    Background: After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of th

  12. Why some groups just feel better : The regulatory fit of group power

    NARCIS (Netherlands)

    Sassenberg, K.; Jonas, K.J; Shah, J.Y; Brazy, P.C

    2007-01-01

    The current research applied the regulatory fit hypothesis (E. T. Higgins, 2000) to the evaluation of groups, suggesting that individuals' group appraisal depends on how well the groups fit their regulatory needs. Specifically, it was predicted that higher power groups would fit and be more valued b

  13. 77 FR 13258 - Biotechnology Regulatory Services; Changes Regarding the Solicitation of Public Comment for...

    Science.gov (United States)

    2012-03-06

    ... Animal and Plant Health Inspection Service Biotechnology Regulatory Services; Changes Regarding the.... FOR FURTHER INFORMATION CONTACT: Dr. T. Clint Nesbitt, Chief of Staff, Biotechnology Regulatory...://www.aphis.usda.gov/biotechnology/pet_proc_imp.shtml . Current Comment Process for Petitions for...

  14. Regulatory Expectations for Safety Culture

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Su Jin; Oh, Jang Jin; Choi, Young Sung [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2014-05-15

    The oversight of licensee's safety culture becomes an important issue that attracts great public and political concerns recently in Korea. Beginning from the intended violation of rules, a series of corruptions, documents forgery and disclosure of wrong-doings made the public think that the whole mindset of nuclear workers has been inadequate. Thus, they are demanding that safety culture shall be improved and that regulatory body shall play more roles and responsibilities for the improvements and oversight for them. This paper introduces, as an effort of regulatory side, recent changes in the role of regulators in safety culture, regulatory expectations on the desired status of licensee's safety culture, the pilot inspection program for safety culture and research activity for the development of oversight system. After the Fukushima accident in Japan 2011, many critics has searched for cultural factors that caused the unacceptable negligence pervaded in Japan nuclear society and the renewed emphasis has been placed on rebuilding safety culture by operators, regulators, and relevant institutions globally. Significant progress has been made in how to approach safety culture and led to a new perspective different from the existing normative assessment method both in operators and regulatory side. Regulatory expectations and oversight of them are based on such a new holistic concept for human, organizational and cultural elements to maintain and strengthen the integrity of defense in depth and consequently nuclear safety.

  15. Flow regime analysis for fluid injection into a confined aquifer: implications for CO2 sequestration

    Science.gov (United States)

    Guo, B.; Zheng, Z.; Celia, M. A.; Stone, H.

    2015-12-01

    Carbon dioxide injection into a confined saline aquifer may be modeled as an axisymmetric two-phase flow problem. Assuming the two fluids segregate in the vertical direction due to strong buoyancy, and neglecting capillary pressure and miscibility, the lubrication approximation leads to a nonlinear advection-diffusion equation that describes the evolution of the sharp fluid-fluid interface. The flow behaviors in the system are controlled by two dimensionless groups: M, the viscosity ratio of the displaced fluid relative to injected fluid, and Γ , the gravity number, which represents the relative importance of buoyancy and fluid injection. Four different analytical solutions can be derived as the asymptotic approximations, representing specific values of the parameter pairs. The four solutions correspond to: (1) Γ 1; and (4) Γ >> 1, any M values. The first two of these solutions are new, while the third corresponds to the solution of Nordbotten and Celia (2006) for confined injections and the fourth corresponds to the solution of (Lyle et al., 2005) for gravity currents in an unconfined aquifer. Overall, the various axisymmetric flows can be summarized in a Γ-M regime diagram with five distinct dynamic behaviors including the four asymptotic regimes and an intermediate regime (Fig. 1). Data from a number of CO2 injection sites around the world can be used to compute the two dimensionless groups Γ and M associated with each injection. When plotted on the regime diagram, these values show the flow behavior for each injection and how the values vary from site to site. For all the CO2 injections, M is always larger than 1, while Γ can range from 0.01 up to 100. The pairs of (Γ, M) with lower Γ values correspond to solution (3), while the ones with higher Γ values can move up to the intermediate regime and the flow regime for solution (4). The higher values of Γ correspond to pilot-scale injections with low injection rates; most industrial-scale injection

  16. On the inward drift of runaway electrons in plateau regime

    CERN Document Server

    Hu, Di

    2016-01-01

    The well observed inward drift of current carrying runaway electrons during runaway plateau regime after disruption is studied by considering the phase space dynamic of runaways in a large aspect ratio toroidal system. We consider the case where the toroidal field is unperturbed and the toroidal symmetry of the system is preserved. The invariance of canonical angular momentum in such system requires runaways to drift horizontally in configuration space for any given change in momentum space. The dynamic of this drift can be obtained by taking the variation of canonical angular momentum. It is then found that runaway electrons will always drift inward as long as they are decelerating. This drift motion is essentially non-linear, since the current is carried by runaways themselves, and any runaway drift relative to the magnetic axis will cause further displacement of the axis itself. A simplified analytical model is constructed to describe such inward drift both in ideal wall case and no wall case, and the runa...

  17. Orbital motion theory and operational regimes for cylindrical emissive probes

    Science.gov (United States)

    Chen, Xin; Sanchez-Arriaga, G.

    2017-02-01

    A full-kinetic model based on the orbital-motion theory for cylindrical emissive probes (EPs) is presented. The conservation of the distribution function, the energy, and the angular momentum for cylindrical probes immersed in collisionless and stationary plasmas is used to write the Vlasov-Poisson system as a single integro-differential equation. It describes self-consistently the electrostatic potential profile and, consequently, the current-voltage (I-V) probe characteristics. Its numerical solutions are used to identify different EP operational regimes, including orbital-motion-limited (OML)/non-OML current collection and monotonic/non-monotonic potential, in the parametric domain of probe bias and emission level. The most important features of the potential and density profiles are presented and compared with common approximations in the literature. Conventional methods to measure plasma potential with EPs are briefly revisited. A direct application of the model is to estimate plasma parameters by fitting I-V measurements to the theoretical results.

  18. Regulatory processes in Aspergillus niger

    DEFF Research Database (Denmark)

    Poulsen, Lars

    some disadvantages as well, those are byproduct formation, secretion of proteolytic enzymes and formation of mycotoxins. The aim of this project was to reduce these disadvantages, though investigating the regulatory processes. The first objective was to study the regulatory events leading to A. niger......T. The physiological batch characterization showed that the ΔprtT strain had the lowest protease activity (fivefold reduced), but also featured excessive CO2 yield, reduced growth rate and lower biomass yields. The ΔprtB strain had a close to twofold reduced levels of secreted proteases but with additional beneficial...

  19. Decarbonization of dominant energetic regime: perspectives on economy of hydrogen in Brazil; Descarbonizacao do regime energetico dominante: perspectivas para a economia do hidrogenio no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Rohrich, Sandra Simm [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil)], E-mail: sandrasimm@ufpr.br; Pereira, Newton Mueller [Universidade Estadual de Campinas (UNICAMP), SP (Brazil)], E-mail: newpe@ige.unicamp.br

    2011-04-15

    Fossil fuels and combustion engine constitute the dominant energy regime, which is a fact that leads to discussions related to energy security, the exhaustion of fossil sources and the need for decarbonization. Hence, the transition to milder energy options for the environment is fully justified. The option analysed in this article is to use hydrogen as an energy vector and the fuel cell as a conversion system, assuming they can influence the entire social structure and lead to the establishment of a hydrogen economy. In this way, the objective of this article is to analyse the conditions under which the current Brazilian energy regime for stationary and transportation energy supply will Incorporate the hydrogen and fuel cells technologies, based on renewable sources. To understand the national context semi-structured Interviews were carried out with the coordinators of the Brazilian road map for structuring the hydrogen economy. (author)

  20. The Existing Regulatory Conditions for 'Energy Smart Water Utilities'

    DEFF Research Database (Denmark)

    Basse, Ellen Margrethe

    2014-01-01

    conditions. Based on these facts, the resource efficiency and low–carbon policy of the EU as well as the EU’s rules of relevance for the utilities are highlighted in section 4. It is concluded that the current EU legislation makes it possible for the Member States to promote energy–smart water utilities...... of the national regulatory design and the problems related to legal barriers are illustrated in section 5 with examples from Danish legislation. The Danish regulatory style is more inflexible than necessary. The benchmarking model and price-cap systems – established as mandatory legal conditions together...

  1. Sediment regime constraints on river restoration - An example from the lower missouri river

    Science.gov (United States)

    Jacobson, R.B.; Blevins, D.W.; Bitner, C.J.

    2009-01-01

    Dammed rivers are subject to changes in their flow, water-quality, and sediment regimes. Each of these changes may contribute to diminished aquatic habitat quality and quantity. Of the three factors, an altered sediment regime is a particularly unyielding challenge on many dammed rivers. The magnitude of the challenge is illustrated on the Lower Missouri River, where the largest water storage system in North America has decreased the downriver suspended-sediment load to 0.2%-17% of predamloads. In response to the altered sediment regime, the Lower Missouri River channel has incised as much as 3.5 m just downstream of Gavins Point Dam, although the bed has been stable to slightly aggrading at other locations farther downstream. Effects of channel engineering and commercial dredging are superimposed on the broad-scale adjustments to the altered sediment regime. The altered sediment regime and geomorphic adjustments constrain restoration and management opportunities. Incision and aggradation limit some objectives of flow-regime management: In incising river segments, ecologically desirable reconnection of the floodplain requires discharges that are beyond operational limits, whereas in aggrading river segments, small spring pulses may inundate or saturate low-lying farmlands. Lack of sediment in the incising river segment downstream of Gavins Point Dam also limits sustainable restoration of sand-bar habitat for bird species listed under the Endangered Species Act. Creation of new shallow-water habitat for native fi shes involves taking sediment out of floodplain storage and reintroducing most or all of it to the river, raising concerns about increased sediment, nutrient, and contaminant loads. Calculations indicate that effects of individual restoration projects are small relative to background loads, but cumulative effects may depend on sequence and locations of projects. An understanding of current and historical sediment fl uxes, and how they vary along the river

  2. Flow regimes in a trapped vortex cell

    Science.gov (United States)

    Lasagna, D.; Iuso, G.

    2016-03-01

    This paper presents results of an experimental investigation on the flow in a trapped vortex cell, embedded into a flat plate, and interacting with a zero-pressure-gradient boundary layer. The objective of the work is to describe the flow features and elucidate some of the governing physical mechanisms, in the light of recent investigations on flow separation control using vortex cells. Hot-wire velocity measurements of the shear layer bounding the cell and of the boundary layers upstream and downstream are reported, together with spectral and correlation analyses of wall-pressure fluctuation measurements. Smoke flow visualisations provide qualitative insight into some relevant features of the internal flow, namely a large-scale flow unsteadiness and possible mechanisms driving the rotation of the vortex core. Results are presented for two very different regimes: a low-Reynolds-number case where the incoming boundary layer is laminar and its momentum thickness is small compared to the cell opening, and a moderately high-Reynolds-number case, where the incoming boundary layer is turbulent and the ratio between the momentum thickness and the opening length is significantly larger than in the first case. Implications of the present findings to flow control applications of trapped vortex cells are also discussed.

  3. Crossing into the substellar regime in Praesepe

    CERN Document Server

    Chappelle, R J; Steele, I A; Dobbie, P D; Magazzù, A

    2005-01-01

    We present the results of a deep optical 2.6 square degree survey with near infrared follow-up measurements of the intermediate-aged Praesepe open cluster. The survey is complete to I=21.3, Z=20.5, corresponding to ~0.06 Solar Masses assuming a cluster age of 0.5 Gyrs. Using 3-5 pass-bands to constrain cluster membership, we identify 32 new low mass cluster members, at least 4 of which are likely to be substellar. We use the low mass census to trace the region where the sequence moves away from the NEXTGEN towards the Dusty regime at Teff = 2200K. In doing so, we identify four unresolved binaries, yielding a substellar binary fraction of ~30 percent. The binary fractions appear to decrease below 0.1 Solar Masses, in contrast to the rising fractions found in the Pleiades. We also identify a paucity of late M dwarfs, thought to be due to a steepening in the mass-luminosity relation at these spectral types, and compare the properties of this gap in the sequence to those observed in younger clusters. We note an o...

  4. On the ontological emergence from quantum regime

    Energy Technology Data Exchange (ETDEWEB)

    Luty, Damian [Adam Mickiewicz University, Poznan (Poland)

    2014-07-01

    There are several views on the relation between quantum physics and theory of relativity (especially General Relativity, GR). A popular perspective is this: GR with its macroscopic gravitational effects will turn out to be a limit of a more fundamental theory which should consider discrete physics and not deal with continuity (like theory of relativity). Thus, GR will emerge from a more basic theory, which should be quantum-like. One could call this an epistemic emergence view towards fundamental theories. The question is, given that scientific realism is valid: should emergence be a fundamental notion in our ontological view about the evolving, physical Universe? Is there an ontological emergence fully compatible with the notion of fundamentality? I argue that if we want to defend ontological emergence (from quantum to macroscopic regime) as something fundamental, we will arrive at the position of metaphysics of dispositions (and I argue, why this is undesirable), or conclude, that we cannot square fully fundamental ontology with the notion of emergence, and that we have to accept an ontological pluralism relativised to a certain scale. I defend the latter proposition, showing, that epistemic emergence doesn't entail (logically) ontological emergence.

  5. Legal regime of water management facilities

    Directory of Open Access Journals (Sweden)

    Salma Jožef

    2013-01-01

    Full Text Available The paper analyzes the legal regime of water management facilities in the light of Serbian, foreign and European law. Different divisions of water management facilities are carried out (to public and private ones, natural and artificial ones, etc., with determination of their legal relevance. Account is taken of the issue of protection from harmful effects of waters to such facilities, as well. The paper points also to rules on the water management facilities, from acts of planning, to individual administrative acts and measures for maintenance of required qualitative and quantitative condition of waters, depending on their purpose (general use or special, commercial use o waters. Albeit special rules on water management facilities exist, due to the natural interlocking between all the components of the environment (water, air and soil, a comprehensive approach is required. A reference is made to other basic principles of protection of water management facilities as well, such as the principle of prevention, principle of sustainable development and the principle "polluter pays". The last one represents the achievement of contemporary law, which deviates from the idea accepted in the second half of 20th century that supported the socialization of risk from harmful effects of waters.

  6. Multimode optomechanical system in the quantum regime

    CERN Document Server

    Nielsen, William H P; Møller, Christoffer B; Polzik, Eugene S; Schliesser, Albert

    2016-01-01

    We realise a simple and robust optomechanical system with a multitude of long-lived ($Q>10^7$) mechanical modes in a phononic-bandgap shielded membrane resonator. An optical mode of a compact Fabry-Perot resonator detects these modes' motion with a measurement rate ($96~\\mathrm{kHz}$) that exceeds the mechanical decoherence rates already at moderate cryogenic temperatures ($10\\,\\mathrm{K}$). Reaching this quantum regime entails, i.~a., quantum measurement backaction exceeding thermal forces, and thus detectable optomechanical quantum correlations. In particular, we observe ponderomotive squeezing of the output light mediated by a multitude of mechanical resonator modes, with quantum noise suppression up to -2.4 dB (-3.6 dB if corrected for detection losses) and bandwidths $\\lesssim 90\\,\\mathrm{ kHz}$. The multi-mode nature of the employed membrane and Fabry-Perot resonators lends itself to hybrid entanglement schemes involving multiple electromagnetic, mechanical, and spin degrees of freedom.

  7. Photonic Crystal Waveguides in Terahertz Regime

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Huaiwu, E-mail: hwzhang@uestc.edu.cn [State Key Laboratory of Electronic Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, 610054 (China)

    2011-02-01

    Using the finite difference time domain method, the electromagnetic field distribution of THz waves in photonic crystals (PCs) T-splitters and Y-splitters had been simulated. The simulation results show that those different T-splitters and Y-splitters can divide the power in an input wave guide equally between two output waveguides. By the improved T-splitter with a rod in the junction, we achieved the 84% amplitude- frequency characteristics consistency of pass-band from 1.12 THz to 1.22 THz, and surpass the 76% consistency of common T-splitter. The improved Y-splitter with a rod in the junction and without rod in the corners has widest -3db bandwidth 0.224 THz, and the amplitude reaches 1655.727. The improved Y-splitter has better performance than other Y-splitters. Introducing the photonic band gap structure with L-type defect composed of three defects. Three high-Q resonant frequencies appeared simultaneously in some monitor coordinates. The wavelength-add-drop properties of L-type defects may be used in multi-carrier communication and multi-frequency-monitoring for the THz regime. Also, a carefully designed PCs can be used as high Q narrowband filter in THz band. These results provide a useful guide and a theoretical basis for the developments of THz functional components.

  8. Legal Regime of Shale Gas Extraction

    Directory of Open Access Journals (Sweden)

    Ovidiu – Horia Maican

    2013-12-01

    Full Text Available Some countries with large reserves intend to promote shale gas production, in order to reduce their dependency on imported gas. Shale gas will be an important new aspect in the world energy scene, with many effects.European Union wants secure and affordable sources of energy. Natural gas is the cleanest fossil fuel and a vital component of European Union's energy strategy. One of the most important aspects is that gas produces significantly cleaner energy than other fossil fuels.From a legal point of view, extraction of oil and natural gas is one of the most highly-regulated activities.In European Union, the regulation of shale gas activities is different if we compare with United States. United States has a complete framework of federal and state regulation of shale gas extraction. More than that, these regulations have evolved in order to respond to the United States shale gas boom.Legal regime of shale gas extraction in every member state of European Union must put together national and European Union regulations in this field of activity.

  9. Exploiting the downhill folding regime via experiment

    Science.gov (United States)

    Muñoz, Victor; Sadqi, Mourad; Naganathan, Athi N.; de Sancho, David

    2008-01-01

    Traditionally, folding experiments have been directed at determining equilibrium and relaxation rate constants of proteins that fold with two-state-like kinetics. More recently, the combination of free energy surface approaches inspired by theory with the discovery of proteins that fold in the downhill regime has greatly widened the battlefield for experimentalists. Downhill folding proteins cross very small or no free energy barrier at all so that all relevant partially folded conformations become experimentally accessible. From these combined efforts we now have tools to estimate the height of thermodynamic and kinetic folding barriers. Procedures to measure with atomic resolution the structural heterogeneity of conformational ensembles at varying unfolding degrees are also available. Moreover, determining the dynamic modes driving folding and how they change as folding proceeds is finally at our fingertips. These developments allow us to address via experiment fundamental questions such as the origin of folding cooperativity, the relationship between structure and stability, or how to engineer folding barriers. Moreover, the level of detail attained in this new breed of experiments should provide powerful benchmarks for computer simulations of folding and force-field refinement. PMID:19436488

  10. Scaling regimes in spherical shell rotating convection

    CERN Document Server

    Gastine, T; Aubert, J

    2016-01-01

    Rayleigh-B\\'enard convection in rotating spherical shells can be considered as a simplified analogue of many astrophysical and geophysical fluid flows. Here, we use three-dimensional direct numerical simulations to study this physical process. We construct a dataset of more than 200 numerical models that cover a broad parameter range with Ekman numbers spanning $3\\times 10^{-7} \\leq E \\leq 10^{-1}$, Rayleigh numbers within the range $10^3 < Ra < 2\\times 10^{10}$ and a Prandtl number unity. We investigate the scaling behaviours of both local (length scales, boundary layers) and global (Nusselt and Reynolds numbers) properties across various physical regimes from onset of rotating convection to weakly-rotating convection. Close to critical, the convective flow is dominated by a triple force balance between viscosity, Coriolis force and buoyancy. For larger supercriticalities, a subset of our numerical data approaches the asymptotic diffusivity-free scaling of rotating convection $Nu\\sim Ra^{3/2}E^{2}$ in ...

  11. Institutional design and regime effectiveness in transboundary river management – the Elbe water quality regime

    Directory of Open Access Journals (Sweden)

    I. Dombrowsky

    2008-02-01

    Full Text Available The literature on transboundary river management suggests that institutions play an important role in bringing about cooperation. However, knowledge about how such institutions should be designed in order to do so remains limited. One way to learn more about adequate institutional design is to assess the effectiveness of existing regimes, and to trace the causal relationships that lead to the respective outcomes. In order to gain further insights into the relationship between institutional design and regime effectiveness, this paper presents a study on the water quality regime of the International Commission for the Protection of the Elbe (ICPE. The analysis is based on a review of pertinent documents and ten qualitative interviews with Czech and German Commission members and NGO representatives. Particular emphasis has been put on determining the ICPE's specific contribution and the no-regime counterfactual as well as on the perceived expediency of the institutional arrangements. The study shows overall that the countries were relatively successful in improving water quality in the Elbe basin. However, this outcome can only partly be attributed to the ICPE itself. Furthermore, the ICPE's contribution towards achieving the various goals varied significantly between the different areas of activity: it was relatively significant where the main responsibility for action lay with the public authorities, such as in the area of wastewater treatment and the establishment of an international alarm plan and model, but was practically non-existent in the reduction of non-point pollution from agriculture, where success depended on the behavior of individual private actors (farmers. The commission contributed towards problem solving by serving as a forum for the joint identification of priorities for action from a basin-wide perspective. The resulting international obligations increased the power of national water administrations and their access to funds

  12. High sensitivity AlGaN/GaN field effect transistor protein sensors operated in the subthreshold regime by a control gate electrode

    Science.gov (United States)

    Wen, Xuejin; Gupta, Samit; Wang, Yuji; Nicholson, Theodore R.; Lee, Stephen C.; Lu, Wu

    2011-07-01

    We demonstrate high sensitivity AlGaN/GaN field effect transistor biosensors with a control gate electrode for streptavidin detection. The device active area is functionalized with 3-Aminopropyltriethoxysilane and N-hydroxysulfosuccinimide-biotin for streptavidin binding. Without any electrochemical side effects, a gate voltage is applied through a Pt control electrode to the solution so that the device operates sensitively in the subthreshold regime. Due to the logarithmic relationship between the channel current and gate voltage in the subthreshold regime, at a concentration of 4.73 pM streptavidin, the device exhibits 9.97% current change in the subthreshold regime compared with the current in phosphate buffered saline solution. In the linear regime, the current change is 0.49% at the same streptavidin concentration.

  13. Innovative farmers and regulatory gatekeepers: Genetically modified crops regulation and adoption in developing countries.

    Science.gov (United States)

    Sinebo, Woldeyesus; Maredia, Karim

    2016-01-02

    The regulation of genetically modified (GM) crops is a topical issue in agriculture and environment over the past 2 decades. The objective of this paper is to recount regulatory and adoption practices in some developing countries that have successfully adopted GM crops so that aspiring countries may draw useful lessons and best practices for their biosafatey regulatory regimes. The first 11 mega-GM crops growing countries each with an area of more than one million hectares in 2014 were examined. Only five out of the 11 countries had smooth and orderly adoption of these crops as per the regulatory requirement of each country. In the remaining 6 countries (all developing countries), GM crops were either introduced across borders without official authorization, released prior to regulatory approval or unapproved seeds were sold along with the approved ones in violation to the existing regulations. Rapid expansion of transgenic crops over the past 2 decades in the developing world was a result of an intense desire by farmers to adopt these crops irrespective of regulatory roadblocks. Lack of workable biosafety regulatory system and political will to support GM crops encouraged unauthorized access to GM crop varieties. In certain cases, unregulated access in turn appeared to result in the adoption of substandard or spurious technology which undermined performance and productivity. An optimal interaction among the national agricultural innovation systems, biosafety regulatory bodies, biotech companies and high level policy makers is vital in making a workable regulated progress in the adoption of GM crops. Factoring forgone opportunities to farmers to benefit from GM crops arising from overregulation into biosafety risk analysis and decision making is suggested. Building functional biosafety regulatory systems that balances the needs of farmers to access and utilize the GM technology with the regulatory imperatives to ensure adequate safety to the environment and human

  14. 75 FR 70757 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...

    Science.gov (United States)

    2010-11-18

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a... 12, 2010. I. Introduction On August 6, 2010, the Financial Industry Regulatory Authority, Inc... Kimmel, Executive Director, Financial Information Forum, to Elizabeth M. Murphy, Secretary,...

  15. 77 FR 47470 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of...

    Science.gov (United States)

    2012-08-08

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Withdrawal... FINRA Rulebook August 2, 2012. On April 22, 2009, the Financial Industry Regulatory Authority,...

  16. 77 FR 55517 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...

    Science.gov (United States)

    2012-09-10

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a.... Introduction On May 24, 2012, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the... General Counsel, Securities Industry and Financial Markets Association, dated June 26, 2012...

  17. 75 FR 62439 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...

    Science.gov (United States)

    2010-10-08

    ...-2010-043] Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving..., 2010. I. Introduction On August 6, 2010, the Financial Industry Regulatory Authority, Inc. (``FINRA..., 2010 (``Wiesenberg Letter''); Letter from Manisha Kimmel, Executive Director, Financial...

  18. 77 FR 12340 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting...

    Science.gov (United States)

    2012-02-29

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting... Accounting Support Fee February 23, 2012. I. Introduction On December 20, 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and Exchange Commission...

  19. 76 FR 20757 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting...

    Science.gov (United States)

    2011-04-13

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting... February 4, 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the...

  20. 75 FR 61793 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2010-10-06

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving... Encrypted September 29, 2010. I. Introduction On June 2, 2010, the Financial Industry Regulatory Authority... Taunt, Chief Executive Officer, Regal Financial Group, to Elizabeth M. Murphy, Secretary,...

  1. Subordinate regulatory mode and leader power: Interpersonal regulatory complementarity predicts task performance

    NARCIS (Netherlands)

    Hamstra, M.R.W.; Orehek, E.; Holleman, M.

    2014-01-01

    This research examines the implications of locomotion regulatory mode (orientation toward making progress on goals) and assessment regulatory mode (orientation toward critically evaluating alternatives) for employees' performance. Regulatory mode theory suggests that, although these are both integra

  2. Multidimensional Plasma Wake Excitation in the Non-linear Blowout Regime

    CERN Document Server

    Vieira, J; Silva, L O

    2016-01-01

    Plasma accelerators can sustain very high acceleration gradients. They are promising candidates for future generations of particle accelerators for sev- eral scientific, medical and technological applications. Current plasma based acceleration experiments operate in the relativistic regime, where the plasma response is strongly non-linear. We outline some of the key properties of wake- field excitation in these regimes. We outline a multidimensional theory for the excitation of plasma wakefields in connection with current experiments. We then use these results and provide design guidelines for the choice of laser and plasma parameters ensuring a stable laser wakefield accelerator that maximizes the quality of the accelerated electrons. We also mention some of the future challenges associated with this technology.

  3. Current limiters

    Energy Technology Data Exchange (ETDEWEB)

    Loescher, D.H. [Sandia National Labs., Albuquerque, NM (United States). Systems Surety Assessment Dept.; Noren, K. [Univ. of Idaho, Moscow, ID (United States). Dept. of Electrical Engineering

    1996-09-01

    The current that flows between the electrical test equipment and the nuclear explosive must be limited to safe levels during electrical tests conducted on nuclear explosives at the DOE Pantex facility. The safest way to limit the current is to use batteries that can provide only acceptably low current into a short circuit; unfortunately this is not always possible. When it is not possible, current limiters, along with other design features, are used to limit the current. Three types of current limiters, the fuse blower, the resistor limiter, and the MOSFET-pass-transistor limiters, are used extensively in Pantex test equipment. Detailed failure mode and effects analyses were conducted on these limiters. Two other types of limiters were also analyzed. It was found that there is no best type of limiter that should be used in all applications. The fuse blower has advantages when many circuits must be monitored, a low insertion voltage drop is important, and size and weight must be kept low. However, this limiter has many failure modes that can lead to the loss of over current protection. The resistor limiter is simple and inexpensive, but is normally usable only on circuits for which the nominal current is less than a few tens of milliamperes. The MOSFET limiter can be used on high current circuits, but it has a number of single point failure modes that can lead to a loss of protective action. Because bad component placement or poor wire routing can defeat any limiter, placement and routing must be designed carefully and documented thoroughly.

  4. Power switch : energy regulatory governance in the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    Doern, G.B. [Carleton Univ., Ottawa, ON (Canada); Gattinger, M. [Ottawa Univ., ON (Canada)

    2003-07-01

    This book presents a critical look at Canada's overall energy regulatory system and explains why the regulatory governance of energy in Canada has changed in the last 20 years in a way that has been characterized by less regulations but more rules. It discusses the contradictory pressures of sectoral deregulation versus the increase in health, safety and environmental rules on the regulatory front. Canada's changing nature of energy regulatory governance in response to the recent continental energy policies by the Bush administration and North American energy markets was also examined. Energy issues gain much political attention when oil, gas or electricity prices rise at abnormal rates as they did in 2000 to 2001. The authors focus on the key institutions and complex regimes of regulation and discuss specific regulatory bodies such as the National Energy Board, the Alberta Energy and Utilities Board, and the Ontario Energy Board. The impact of the Kyoto Protocol on environmental and climate change regulations was also discussed with reference to regulatory actions that are needed to reduce greenhouse gas emissions. Issues of national and continental energy security were also addressed. refs., tabs., figs.

  5. Origin of the hysteresis in bilayer 2D systems in the quantum Hall regime

    OpenAIRE

    Ho, L. H.; Taskinen, L. J.; Micolich, A.P.; Hamilton, A. R.; Atkinson, P.; Ritchie, D. A.

    2010-01-01

    The hysteresis observed in the magnetoresistance of bilayer 2D systems in the quantum Hall regime is generally attributed to the long time constant for charge transfer between the 2D systems due to the very low conductivity of the quantum Hall bulk states. We report electrometry measurements of a bilayer 2D system that demonstrate that the hysteresis is instead due to non-equilibrium induced current. This finding is consistent with magnetometry and electrometry measurements of single 2D syste...

  6. Interconnection between static regimes in the LJJs described by the double sine-Gordon equation

    Science.gov (United States)

    Atanasova, P. Kh; Zemlyanaya, E. V.; Shukrinov, Yu M.

    2012-11-01

    The second harmonic contribution to the current-phase relation changes the properties of the static magnetic flux distributions in the long Josephson junction (LJJ) and inspires new homogenious and fluxon static states. We study stability properties and bifurcations of these static regimes within the frame of a model described by the double sine-Gordon equation. The critical curves behavior and the interconnection between different types of magnetic flux distributions are analyzed.

  7. Fick's Law for the Lorentz Model in a weak coupling regime

    OpenAIRE

    Nota, Alessia

    2014-01-01

    In this paper we deal with further recent developments, strictly connected to the recent result obtained by Basile, Nota, Pezzotti and Pulvirenti. We consider the Lorentz gas out of equilibrium in a weak coupling regime. Each obstacle of the Lorentz gas generates a smooth radially symmetric potential with compact support. We prove that the macroscopic current in the stationary state is given by the Fick's law of diffusion. The diffusion coefficient is given by the Green-Kubo formula associate...

  8. CO-MOVEMENTS OF REGIME SHIFTS IN GBP CURRENCY PAIRS AROUND BOE QUANTITATIVE EASING ANNOUNCEMENTS

    Directory of Open Access Journals (Sweden)

    Radu LUPU

    2014-10-01

    Full Text Available In the current post-crisis era, the events with the highest probability to move the financial markets are the announcements of financial authorities concerning the quantitative easing decisions. The objective of this paper is to build an analysis of the existence of connections among the GBP currency pairs in terms of regime switching that could be related to the moments when the Bank of England generated announcements about its monetary decisions.

  9. Monetary Regimes and Policy on a Global Scale: The Oeuvre of Michael D. Bordo

    OpenAIRE

    Rockoff, Hugh; Eugene N. White

    2012-01-01

    Michael D. Bordo has helped to define the modern field of monetary history, drawing from it important policy lessons for current practitioners. For his seventieth year, we survey his contributions to our understanding of the Great Depression, money and the economy in historical perspective, exchange rate regimes including the gold standard, Bretton Woods, and the European Monetary Union, globalization, financial crises, the Canadian monetary experience, and historical guidance for monetary p...

  10. Lymph node trafficking of regulatory T cells is prerequisite for immune suppression.

    Science.gov (United States)

    Huang, Miao-Tzu; Lin, Been-Ren; Liu, Wei-Liang; Lu, Chun-Wei; Chiang, Bor-Luen

    2016-04-01

    Regulatory T cells have a crucial role in health and disease because of their immune regulation function. However, the anatomic sites where regulatory T cells exert optimal immune regulation are open to debate. In our current study with the use of a shear-stress flow assay, we found that regulatory T cells exhibited significantly decreased adhesion to either activated endothelial monolayer or intercellular adhesion molecule 1 or E-selectin-coated surfaces compared with activated effector T cells. The less transmigration capacity of the regulatory T cells prompted our speculation of preferential lymph node localization for the regulatory T cells that endowed these cells with immune regulation function in the most efficient manner. To test this hypothesis, the role of lymph node localization in regulatory T cell-mediated immune suppression was evaluated with a footpad inflammation model. We found that adoptively transferred regulatory T cells inhibited the development of footpad inflammation. In addition, although blockage of CCR7 or CD62L had no effect on the immune suppressive function of the regulatory T cells per se, pretreatment of the regulatory T cells with either CCR7 or CD62L blocking antibodies prevented their recruitment into draining lymph nodes and concomitantly abrogated the immune suppressive effects of adoptively transferred regulatory T cells during footpad inflammation. Our data demonstrate the crucial role of lymph node localization in regulatory T cell-mediated immune suppression and suggest a probable hierarchy in the anatomic sites for optimal immune regulation. Elucidating the relationships between the transmigration characteristics of the regulatory T cells and their immune regulation function will provide insightful information for regulatory T cell-based cell therapy.

  11. The seismology of geothermal regimes. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Aki, K.

    1997-04-01

    The authors have been developing seismological interpretation theory and methods applicable to complex structures encountered in geothermal areas for a better understanding of the earth`s geothermal regimes. The questions the y have addressed in their research may be summarized as ``What is going on in the earth`s crust under tectonically active regions; what are the structures and processes responsible for such activities as earthquakes and volcanic eruptions; and how can one capture their essence effectively by means of seismological studies?`` First, the authors found clear evidence for localization of scattered seismic energy in the deep magmatic system of the volcano on the island of Reunion in the Indian Ocean. The seismic coda of local earthquakes show concentrated energy in the intrusive zones as late as 30 to 40 seconds after the origin time. This offers a very effective method for defining a zone of strong heterogeneity on a regional scale, complementary to the high resolution study using trapped modes as pursued in the past project. Secondly, the authors identified about 700 long-period events with various frequencies and durations from the data collected during the past 5 years which included three episodes of eruption. They are applying a finite-element method to the simplest event with the longest period and the shortest duration in order to find the location, geometry and physical properties of their source deterministically. The preliminary result described here suggests that their sources may be a horizontally lying magma-filled crack at a shallow depth under the summit area. In addition to the above work on the Reunion data, they have continued the theoretical and observational studies of attenuation and scattering of seismic waves.

  12. CSDP: Seismology of continental thermal regime

    Energy Technology Data Exchange (ETDEWEB)

    Aki, K.

    1989-04-01

    This is a progress report for the past one year of research (year 2 of 5-year project) under the project titled CSDP: Seismology of Continental Thermal Regime'', in which we proposed to develop seismological interpretation theory and methods applicable to complex structures encountered in continental geothermal areas and apply them to several candidate sites for the Continental Scientific Drilling Project. During the past year, two Ph.D. thesis works were completed under the present project. One is a USC thesis on seismic wave propagation in anisotropic media with application to defining fractures in the earth. The other is a MIT thesis on seismic Q and velocity structure for the magma-hydrothermal system of the Valles Caldera, New Mexico. The P.I. co-organized the first International Workshop on Volcanic Seismology at Capri, Italy in October 1988, and presented the keynote paper on the state-of-art of volcanic seismology''. We presented another paper at the workshop on Assorted Seismic Signals from Kilauea Volcano, Hawaii. Another international meeting, namely, the Chapman Conference on seismic anisotropy in the earth's crust at Berkeley, California in May 1988, was co-organized by the co-P.I. (P.C.L), and we presented our work on seismic waves in heterogeneous and anisotropic media. Adding the publications and presentations made in the past year to the list for the preceding year, the following table lists 21 papers published, submitted or presented in the past two years of the present project. 65 refs., 334 figs., 1 tab.

  13. Regulating Cannabis Social Clubs: A comparative analysis of legal and self-regulatory practices in Spain, Belgium and Uruguay.

    Science.gov (United States)

    Decorte, Tom; Pardal, Mafalda; Queirolo, Rosario; Boidi, Maria Fernanda; Sánchez Avilés, Constanza; Parés Franquero, Òscar

    2017-05-01

    Cannabis Social Clubs (CSCs) are a model of non-profit production and distribution of cannabis among a closed circuit of adult cannabis users. CSCs are now operating in several countries around the world, albeit under very different legal regimes and in different socio-political contexts. In this paper we describe and compare the legal framework and the self-regulatory practices of Cannabis Social Clubs in three countries (Spain, Belgium, and Uruguay). The objective of our comparative analysis is to investigate how CSCs operate in each of these countries. To foster discussions about how one might regulate CSCs to promote public health objectives, we conclude this paper with a discussion on the balance between adequate governmental control and self-regulatory competences of CSCs. The data used for this analysis stem from independently conducted local studies by the authors in their countries. Although the particular designs of the studies differ, the data in all three countries was collected through similar data collection methods: analysis of (legal and other documents), field visits to the clubs, interviews with staff members, media content analysis. We identified a number of similarities and differences among the CSCs' practices in the three countries. Formal registration as non-profit association seems to be a common standard among CSCs. We found nevertheless great variation in terms of the size of these organisations. Generally, only adult nationals and/or residents are able to join the CSCs, upon the payment of a membership fee. While production seems to be guided by consumption estimates of the members (Spain and Belgium) or by the legal framework (Uruguay), the thresholds applied by the clubs vary significantly across countries. Quality control practices remain an issue in the three settings studied here. The CSCs have developed different arrangements with regards to the distribution of cannabis to their members. By uncovering the current practices of CSCs

  14. Biopiracy after the Nagoya Protocol: Problem Structure, Regime Design and Implementation Challenges

    Directory of Open Access Journals (Sweden)

    Florian Rabitz

    2015-08-01

    Full Text Available This article assesses the effectiveness of the 2010 Nagoya Protocol to the Convention on Biological Diversity (CBD for addressing "biopiracy" of genetic resources; that is, their biotechnological utilization in violation of either the provider country legislation or mutually agreed contractual obligations. Biopiracy is defined as a problem resulting from a distributive conflict between provider and user countries, the practical difficulties of monitoring the utilization of genetic resources in a transnational context, and the pervasive scientific uncertainty about the nature and extent of the problem. The Nagoya Protocol predominantly focuses on compliance management while lacking the necessary enforcement provisions for deterring non-compliance through effective monitoring and sanctions. Using the example of recent European Union implementing legislation, this article underscores how parties may use the Protocol's legal ambiguities to soften its regulatory impact on domestic industry. As a result, in light of both problem structure and regime design, the Protocol only offers modest improvements over the status quo ante.

  15. Transition to ballistic regime for heat transport in helium II

    Energy Technology Data Exchange (ETDEWEB)

    Sciacca, Michele, E-mail: michele.sciacca@unipa.it [Dipartimento Scienze Agrarie e Forestali, Università degli studi di Palermo, Viale delle Scienze, 90128 Palermo (Italy); Departament de Física, Universitat Autònoma de Barcelona, 08193 Bellaterra, Catalonia (Spain); Sellitto, Antonio, E-mail: ant.sellitto@gmail.com [Dipartimento di Matematica, Informatica ed Economia, Università della Basilicata, Campus Macchia Romana, 85100 Potenza (Italy); Jou, David, E-mail: david.jou@uab.cat [Departament de Física, Universitat Autònoma de Barcelona, 08193 Bellaterra, Catalonia (Spain); Institut d' Estudis Catalans, Carme 47, 08001 Barcelona, Catalonia (Spain)

    2014-07-04

    The size-dependent and flux-dependent effective thermal conductivity of narrow capillaries filled with superfluid helium is analyzed from a thermodynamic continuum perspective. The classical Landau evaluation of the effective thermal conductivity of quiescent superfluid, or the Gorter–Mellinck regime of turbulent superfluids, is extended to describe the transition to ballistic regime in narrow channels wherein the radius R is comparable to (or smaller than) the phonon mean-free path ℓ in superfluid helium. To do so, we start from an extended equation for the heat flux incorporating non-local terms, and take into consideration a heat slip flow along the walls of the tube. This leads from an effective thermal conductivity proportional to R{sup 2} (Landau regime) to another one proportional to Rℓ (ballistic regime). We consider two kinds of flows: along cylindrical pipes and along two infinite parallel plates. - Highlights: • Heat transport in counterflow helium in the ballistic regime. • The one-fluid model based on the Extended Thermodynamics is used. • The transition from the Landau regime to the ballistic regime. • The transition from quantum turbulence to ballistic regime.

  16. Disciplinary Regimes of "Care" and Complementary Alternative Education

    Science.gov (United States)

    Thomson, Pat; Pennacchia, Jodie

    2016-01-01

    In schools, the notion of "care" is often synonymous with welfare and disciplinary regimes. Drawing on Foucault, and a study of alternative education (AE) across the UK, and looking in depth at two cases of complementary AE, we identify three types of disciplinary regimes at work in schools: (1) dominant performative reward and…

  17. Spectral classification of coupling regimes in the quantum Rabi model

    Science.gov (United States)

    Rossatto, Daniel Z.; Villas-Bôas, Celso J.; Sanz, Mikel; Solano, Enrique

    2017-07-01

    The quantum Rabi model is in the scientific spotlight due to the recent theoretical and experimental progress. Nevertheless, a full-fledged classification of its coupling regimes remains as a relevant open question. We propose a spectral classification dividing the coupling regimes into three regions based on the validity of perturbative criteria on the quantum Rabi model, which allows us the use of exactly solvable effective Hamiltonians. These coupling regimes are (i) the perturbative ultrastrong coupling regime which comprises the Jaynes-Cummings model, (ii) a region where nonperturbative ultrastrong and nonperturbative deep strong coupling regimes coexist, and (iii) the perturbative deep strong coupling regime. We show that this spectral classification depends not only on the ratio between the coupling strength and the natural frequencies of the unperturbed parts, but also on the energy to which the system can access. These regimes additionally discriminate the completely different behaviors of several static physical properties, namely the total number of excitations, the photon statistics of the field, and the cavity-qubit entanglement. Finally, we explain the dynamical properties which are traditionally associated with the deep strong coupling regime, such as the collapses and revivals of the state population, in the frame of the proposed spectral classification.

  18. Bargaining among Nations: Culture, History, and Perceptions in Regime Formation.

    Science.gov (United States)

    Lipschutz, Ronnie D.

    1991-01-01

    The formation of regimes (collective international schemes) for managing global problems depends on culture, history, and perceptions. The ways in which these elements affect bargaining among nations over issues of the global commons are discussed. Implications are reviewed for a regime to deal with atmospheric conditions and global warming. (SLD)

  19. Welfare regimes and the incentives to work and get educated

    NARCIS (Netherlands)

    Rodriguez-Pose, Andres; Tselios, Vassilis

    This paper examines whether differences in welfare regimes shape the incentives to work and get educated. Using microeconomic data for more than 100 ON European individuals, we show that welfare regimes make a difference for wages and education. First, people-based and household-based effects

  20. Welfare regimes and the incentives to work and get educated

    NARCIS (Netherlands)

    Rodriguez-Pose, Andres; Tselios, Vassilis

    2012-01-01

    This paper examines whether differences in welfare regimes shape the incentives to work and get educated. Using microeconomic data for more than 100 ON European individuals, we show that welfare regimes make a difference for wages and education. First, people-based and household-based effects (inter

  1. Minxin Pei, China's Crony Capitalism: The Dynamics of Regime Decay

    DEFF Research Database (Denmark)

    Brødsgaard, Kjeld Erik

    2017-01-01

    Book review of: Minxin Pei, China's Crony Capitalism: The Dynamics of Regime Decay. Cambridge, Mass.: Harvard University Press, 2016. 365 pp., including references and index. ISBN 9780674737297.......Book review of: Minxin Pei, China's Crony Capitalism: The Dynamics of Regime Decay. Cambridge, Mass.: Harvard University Press, 2016. 365 pp., including references and index. ISBN 9780674737297....

  2. Current Status of JRR-3

    Energy Technology Data Exchange (ETDEWEB)

    Kinase, Masami; Arai, Masaji; Maruo, Takeshi [Japan Atomic Energy Agency, Ibaraki (Japan)

    2013-07-01

    JRR-3 at the Tokai-Shirakata site of JAEA was in its regular maintenance period, when the Great East Japan Earthquake took place on 11th March 2011. The reactor building with the solid foundations and the equipment important to safety survived the earthquake without serious damage, and no radioactive leakage has been occurred. Recovery works, check and test to confirm the integrity of all components and structures, and seismic assessment necessary for proving that the seismic loads which worked on a structure or component by the earthquake accommodated within its allowable stress have been carried out. After our recovery works and verification of the integrity of JRR-3, we confirmed that the integrity is ensured, and then reported the fact to the regulatory body. As another topic, the regulatory body will introduce new regulatory requirements for research reactors. Now, JRR-3 considers applying the new requirements for restart. This paper presents the current status of JRR-3 including the recovery works, seismic assessment and new regulatory requirements.

  3. Thermodynamics of the mesoscopic thermoelectric heat engine beyond the linear-response regime

    Science.gov (United States)

    Yamamoto, Kaoru; Hatano, Naomichi

    2015-10-01

    Mesoscopic thermoelectric heat engine is much anticipated as a device that allows us to utilize with high efficiency wasted heat inaccessible by conventional heat engines. However, the derivation of the heat current in this engine seems to be either not general or described too briefly, even inappropriately in some cases. In this paper, we give a clear-cut derivation of the heat current of the engine with suitable assumptions beyond the linear-response regime. It resolves the confusion in the definition of the heat current in the linear-response regime. After verifying that we can construct the same formalism as that of the cyclic engine, we find the following two interesting results within the Landauer-Büttiker formalism: the efficiency of the mesoscopic thermoelectric engine reaches the Carnot efficiency if and only if the transmission probability is finite at a specific energy and zero otherwise; the unitarity of the transmission probability guarantees the second law of thermodynamics, invalidating Benenti et al.'s argument in the linear-response regime that one could obtain a finite power with the Carnot efficiency under a broken time-reversal symmetry [Phys. Rev. Lett. 106, 230602 (2011), 10.1103/PhysRevLett.106.230602]. These results demonstrate how quantum mechanics constrains thermodynamics.

  4. Characterization of the Tokamak Novillo in cleaning regime; Caracterizacion del Tokamak Novillo en regimen de limpieza

    Energy Technology Data Exchange (ETDEWEB)

    Lopez C, R.; Melendez L, L.; Valencia A, R.; Chavez A, E.; Colunga S, S.; Gaytan G, E

    1992-02-15

    In this work the obtained results of the investigation about the experimental characterization of those low energy pulsed discharges of the Tokamak Novillo are reported. With this it is possible to fix the one operation point but appropriate of the Tokamak to condition the chamber in the smallest possible time for the cleaning discharges regime before beginning the main discharge. The characterization of the cleaning discharges in those Tokamaks is an unique process and characteristic of each device, since the good points of operation are consequence of those particularities of the design of the machine. In the case of the Tokamak Novillo, besides characterizing it a contribution is made to the cleaning discharges regime which consists on the one product of the current peak to peak of plasma by the duration of the discharge Ip{sub t} like reference parameter for the optimization of the operation of the device in the cleaning discharge regime. The maximum value of the parameter I{sub (p)}t, under different work conditions, allowed to find the good operation point to condition the discharges chamber of the Tokamak Novillo in short time and to arrive to a regime in which is not necessary the preionization for the obtaining of the cleaning discharges. (Author)

  5. Simulation of an optomechanical quantum memory in the nonlinear regime

    Science.gov (United States)

    Teh, R. Y.; Kiesewetter, S.; Reid, M. D.; Drummond, P. D.

    2017-07-01

    Optomechanical systems cooled to the quantum level provide a promising mechanism for a high-fidelity quantum memory that is faithful to a given temporal mode structure, and can be recovered synchronously. We carry out full, probabilistic quantum simulation of a quantum optomechanical memory, including nonlinear effects that are usually ignored. This is achieved using both the approximate truncated Wigner and the exact positive P phase-space representations. By considering the nonlinear quantum optomechanical Hamiltonian, our simulations allow us to probe the regime where the linearization approximation fails to hold. We show evidence for large spectral overlap between the quantum signal and the transfer field in typical optomechanical quantum memory experiments. Methods for eliminating this overlap to accurately recover the quantum signal are discussed. This allows us to give a complete model for the quantum storage of a coherent state. We treat the mode matching that is necessary to accurately retrieve the stored quantum state, by including the internal dynamics of the mechanical system as well as the optical system. We also include the finite switching time of the control transfer field. The fidelity for the storage of a coherent state is computed numerically using currently realistic experimental parameters in the electromechanical case. We find the expected fidelity is lower than required to demonstrate true quantum state transfers. Significant improvements in the quality factor of the cavity and mechanical systems will, however, increase the fidelity beyond the quantum threshold.

  6. Smoke consequences of new wildfire regimes driven by climate change

    Science.gov (United States)

    McKenzie, Donald; Shankar, Uma; Keane, Robert E.; Stavros, E. Natasha; Heilman, Warren E.; Fox, Douglas G.; Riebau, Allen C.

    2014-02-01

    Smoke from wildfires has adverse biological and social consequences, and various lines of evidence suggest that smoke from wildfires in the future may be more intense and widespread, demanding that methods be developed to address its effects on people, ecosystems, and the atmosphere. In this paper, we present the essential ingredients of a modeling system for projecting smoke consequences in a rapidly warming climate that is expected to change wildfire regimes significantly. We describe each component of the system, offer suggestions for the elements of a modeling agenda, and provide some general guidelines for making choices among potential components. We address a prospective audience of researchers whom we expect to be fluent already in building some or many of these components, so we neither prescribe nor advocate particular models or software. Instead, our intent is to highlight fruitful ways of thinking about the task as a whole and its components, while providing substantial, if not exhaustive, documentation from the primary literature as reference. This paper provides a guide to the complexities of smoke modeling under climate change, and a research agenda for developing a modeling system that is equal to the task while being feasible with current resources.

  7. Extensional Tectonic Regime of Garut Basin based on Magnetotelluric Analysis

    Directory of Open Access Journals (Sweden)

    Lina Handayani

    2014-07-01

    Full Text Available DOI: 10.17014/ijog.v8i3.162Garut Basin are is part of Bandung-Garut Greater Basin (Bandung Zone characterized by a large basin surrounded by mountain ranges. Active volcanoes had distributed their material as pyroclastic deposits around the outer border of the zone and as lava flow deposit separating the two basins. Bouguer gravity anomaly data had also indicated the presence of several low anomaly closures at about the area of Bandung and Garut Basins that were surrounded by high gravity anomaly zones. Two magnetotelluric surveys were completed to acquire the subsurface model that might explain the tectonic evolution of studied area. The first stage was characterized sby the presence of horst - graben structures that might imply an extensional regime of the area. The next stage of evolutionwas indicated by the horizontal layering correlated to the relative non-active tectonic. In addition, a most recent structure that appeared near the surface might suggest a possible extension force as the current stage.

  8. Loop Quantum Gravity and the The Planck Regime of Cosmology

    CERN Document Server

    Ashtekar, Abhay

    2013-01-01

    The very early universe provides the best arena we currently have to test quantum gravity theories. The success of the inflationary paradigm in accounting for the observed inhomogeneities in the cosmic microwave background already illustrates this point to a certain extent because the paradigm is based on quantum field theory on the curved cosmological space-times. However, this analysis excludes the Planck era because the background space-time satisfies Einstein's equations all the way back to the big bang singularity. Using techniques from loop quantum gravity, the paradigm has now been extended to a self-consistent theory from the Planck regime to the onset of inflation, covering some 11 orders of magnitude in curvature. In addition, for a narrow window of initial conditions, there are departures from the standard paradigm, with novel effects, such as a modification of the consistency relation involving the scalar and tensor power spectra and a new source for non-Gaussianities. Thus, the genesis of the lar...

  9. THE FISCAL ANTI-FRAUD CONTROL. LEGAL REGIME

    Directory of Open Access Journals (Sweden)

    Rada POSTOLACHE

    2014-05-01

    Full Text Available The fiscal anti-fraud control has been regulated quite recently, by the Government Emergency Ordinance No. 74/2013, adopted in the context of the implementation of the “Project for the modernization of the fiscal administration” and the intensification of the fight against tax evasion. On the basis of the legal norms applying to it, of specialized doctrine and legal literature, the present work aims to approach fiscal control from various perspectives – organization, enforcement and definition of legal accountability – so as to point at the same time its specific forms, in relation to other similar control forms. Moreover, the present work will also analyse the novelty elements which the law brings, so as to create a specific technical support for the authorities, regarding those case laws having as object the economic-financial frauds. The current study aims to delineate the legal regime of this control form, which we consider a specialized activity, organized within the National Agency of Fiscal Administration and performed with the specific target of control, so as to prevent, acknowledge and fight tax evasion. At the same time, the present study is useful under the present circumstances, in which fiscal fraud has become more intense, becoming a phenomenon, but also because fiscal fraud has incidence upon other field of economic and financial interest.

  10. Assessing the extreme overwash regime along an embayed urban beach

    Science.gov (United States)

    Silveira, Tanya M.; Taborda, Rui; Carapuço, Mafalda M.; Andrade, César; Freitas, Maria C.; Duarte, João F.; Psuty, Norbert P.

    2016-12-01

    Coastal overwash is one of the most important hazards affecting the coastal zone and therefore has been the focus of several studies related to the establishment of setback lines. However, studies of extreme overwash (EO) events along urban beaches backed by a seawall or structure are scarce, and reveal the difficulties associated with its assessment, measurement and validation. The Nazaré coastal urban area (located on the west coast of Portugal) is developed adjacent to an embayed reflective beach and is subject to frequent and localized inundation due to EO events capable of overtopping the protection seawall. The current work develops a methodological approach to simulate total water levels (TWL) and seawall overtopping occurrences in time and space, with the ultimate goal of identifying the factors that govern the extreme overwash regime. The method uses multi-decadal time series of site-specific wave and tide, and high-resolution topo-bathymetric data, and recreates the TWL time series for a 36-year period. The model is successfully validated against video imagery and maximum swash line data that provide information on the reach of the water levels measured during modal and extreme TWL conditions along the studied beach. This study establishes the importance of the interaction of the modal and extreme hydrodynamic processes with the beach and backshore morphology. The Nazaré embayment is in equilibrium with the alongshore-varying modal wave conditions, resulting in higher vulnerability of the most sheltered sector during extreme events.

  11. Current issues with research support

    Energy Technology Data Exchange (ETDEWEB)

    Russell, W.T.

    1996-03-01

    It would be difficult to condense current issues in nuclear reactor regulation to just a few minutes. So, let me start off by saying that I have not tried to give a comprehensive listing of issues that are currently facing the reactor program, but rather to select those that I thought were relevant as they relate to research activities. Use of probabilistic risk assessment in regulatory decisions; materials aging issues concerning steam generators and reactor vessels; high burnup fuels; accident management; and digital instrumentation and control, are just a sampling of the important issues that I want to talk about.

  12. Uterus transplantation: ethical and regulatory challenges.

    Science.gov (United States)

    Arora, Kavita Shah; Blake, Valarie

    2014-06-01

    Moving forward rapidly in the clinical research phase, uterus transplantation may be a future treatment option for women with uterine factor infertility, which accounts for three per cent of all infertility in women. This new method of treatment would allow women, who currently rely on gestational surrogacy or adoption, to gestate and birth their own genetic offspring. Since uterus transplantation carries significant risk when compared with surrogacy and adoption as well as when compared with other organ transplants, it requires greater justification because its goals are quality of life, not life-saving, in their scope. It is important to address questions regarding the physical, psychosocial and ethical risks and benefits of uterus transplantation for all three parties involved--the patient, the donor and the potential child--as well as discuss the regulatory implications as research on uterus transplantations moves forward.

  13. Vaccines in Argentina: a regulatory view.

    Science.gov (United States)

    Pérez, A C; Diez, R A

    2003-07-28

    In Argentina, vaccines for immuno-preventable diseases are regulated by the national regulatory agency, the Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (the National Administration of Drugs, Food and Medical Devices, or ANMAT) created in 1992 to ensure efficacy and safety of drugs, food and medical devices available in the country, according to Law 16,463 and Decree 150/92. ANMAT has licensed 84 out of 157 vaccines registered in Argentina. Since 1994, ANMAT evaluated, approved and inspected 20 clinical trials with vaccines (1.8% of the 1062 trials approved by the agency since that time). The National System of Pharmaco-vigilance has received 318 communications of eventual adverse post-vaccination events (0.3% of the total). In addition, ANMAT provides support to the National Immunisation Programme. The current procedure is to follow international guidelines in the field, to be prepared for new, rapidly changing scenarios.

  14. Mechanisms of T regulatory cell function.

    Science.gov (United States)

    Askenasy, Nadir; Kaminitz, Ayelet; Yarkoni, Shai

    2008-05-01

    Regulatory T cells (Treg) play a pivotal role in tolerance to self-antigens and tissue grafts, and suppression of autoimmune reactions. These cells modulate the intensity and quality of immune reactions through attenuation of the cytolytic activities of reactive immune cells. Treg cells operate primarily at the site of inflammation where they modulate the immune reaction through three major mechanisms: a) direct killing of cytotoxic cells through cell-to-cell contact, b) inhibition of cytokine production by cytotoxic cells, in particular interleukin-2, c) direct secretion of immunomodulatory cytokines, in particular TGF-beta and interleukin-10. In addition to differential contributions of these mechanisms under variable inflammatory conditions, mechanistic complexity and diversity evolves from the diverse tasks performed by various Treg cell subsets in different stages of the immune reaction. Here we attempt to integrate the current experimental evidence to delineate the major suppressive pathways of Treg cells.

  15. The Role of Regulatory Agencies and Intellectual Property: Part I.

    Science.gov (United States)

    Noonan, Kevin E

    2015-03-16

    The patent and regulatory regimes of different agencies of the federal government are not always in agreement, and although the concept of the "unified executive" holds that the executive branch speaks with one voice, that is not always the case.(1) Some agencies, like the Food and Drug Administration, tend toward cooperation with government patent policies, whereas others, notably the Federal Trade Commission, are often at odds with the Patent Office, the patent system, or both. These skirmishes, when they arise, eventually come before federal courts and ultimately the Supreme Court, where balancing the differing policy objectives, as well as the will of Congress as embodied in its statutes, is subject to the vagaries of the politics of how the issues are framed by the courts, and the judges' and justices' own predilections and prejudices. Examples of these situations were prevalent in 2013 and the circumstances surrounding them illustrative of the tensions inherent between the various federal agencies.

  16. The Political Economy of Regulatory Risk

    OpenAIRE

    Roland Strausz

    2009-01-01

    I investigate the argument that, in a two–party system with different regulatory objectives, political uncertainty generates regulatory risk. I show that this risk has a fluctuation effect that hurts both parties and an output–expansion effect that benefits one party. Consequently, at least one party dislikes regulatory risk. Moreover, both political parties gain from eliminating regulatory risk when political divergence is small or the winning probability of the regulatory–risk–averse party ...

  17. The political economy of regulatory risk

    OpenAIRE

    Strausz, Roland

    2009-01-01

    I investigate the argument that, in a twoparty system with different regulatory objectives, political uncertainty generates regulatory risk. I show that this risk has a fluctuation effect that hurts both parties and an outputexpansion effect that benefits one party. Consequently, at least one party dislikes regulatory risk. Moreover, both political parties gain from eliminating regulatory risk when political divergence is small or the winning probability of the regulatoryriskaverse party is n...

  18. Nuclear Regulatory Commission 1989 Information Digest

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1989-03-01

    The Nuclear Regulatory Commission 1989 Information Digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the Commission. This is the first of an annual publication for the general use of the NRC staff and is available to the public. The Digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  19. Boundary between Stable and Unstable Regimes of Accretion. Ordered and Chaotic Unstable Regimes

    CERN Document Server

    Blinova, A A; Lovelace, R V E

    2015-01-01

    We search for the boundary between stable and Rayleigh-Taylor unstable regimes of accretion to magnetized stars in a new set of high grid resolution simulations. We found that the boundary between stable and unstable regimes is mainly determined by the ratio of the corotation radius r_cor (where the Keplerian angular velocity in the disc matches the angular velocity of the star) to the magnetospheric radius r_m (where the magnetic stress in the magnetosphere matches the matter stress in the disc). Instability is stronger when r_cor is larger with respect to r_m, that is, when the gravitational force is larger than the centrifugal force at the inner disc. In the cases of a small tilt of the magnetosphere, Theta=5 deg, and a small alpha-parameter of viscosity, alpha=0.02, the boundary is located at r_cor approx. 1.4 r_m. Instability becomes stronger at higher values of viscosity, and occurs at lower values of r_cor/r_m. At higher values of Theta, the variability associated with instability decreases. Simulation...

  20. Regulatory Compliance in Multi-Tier Supplier Networks

    Science.gov (United States)

    Goossen, Emray R.; Buster, Duke A.

    2014-01-01

    Over the years, avionics systems have increased in complexity to the point where 1st tier suppliers to an aircraft OEM find it financially beneficial to outsource designs of subsystems to 2nd tier and at times to 3rd tier suppliers. Combined with challenging schedule and budgetary pressures, the environment in which safety-critical systems are being developed introduces new hurdles for regulatory agencies and industry. This new environment of both complex systems and tiered development has raised concerns in the ability of the designers to ensure safety considerations are fully addressed throughout the tier levels. This has also raised questions about the sufficiency of current regulatory guidance to ensure: proper flow down of safety awareness, avionics application understanding at the lower tiers, OEM and 1st tier oversight practices, and capabilities of lower tier suppliers. Therefore, NASA established a research project to address Regulatory Compliance in a Multi-tier Supplier Network. This research was divided into three major study efforts: 1. Describe Modern Multi-tier Avionics Development 2. Identify Current Issues in Achieving Safety and Regulatory Compliance 3. Short-term/Long-term Recommendations Toward Higher Assurance Confidence This report presents our findings of the risks, weaknesses, and our recommendations. It also includes a collection of industry-identified risks, an assessment of guideline weaknesses related to multi-tier development of complex avionics systems, and a postulation of potential modifications to guidelines to close the identified risks and weaknesses.