WorldWideScience

Sample records for current policy options

  1. European Regional Populations: Current Trends, Future Pathways, and Policy Options.

    Science.gov (United States)

    Rees, Philip; van der Gaag, Nicole; de Beer, Joop; Heins, Frank

    2012-11-01

    Europe is currently experiencing an ageing population and slowing population growth of both the total and working-age populations. These trends are likely to continue. Even though population ageing will affect all European regions, different regions will be affected in different ways. Even under favorable conditions, 35-40 % of all NUTS2 regions will face a labor force decline. If economic conditions are poor, some regions may continue to grow, but 55-70 % of the regions will see a labor force decline by 10 % or more. In most regions of Eastern Europe, the labor force may decrease by more than 30 %. To keep regions prosperous (maintaining competitiveness) and to avoid worse inequality (maintaining cohesion), policy-makers must find ways to cope with these challenges through new fiscal and social policies, though policies directly affecting demographic and migratory trends may also be needed.

  2. European regional populations: current trends, future pathways and policy options

    NARCIS (Netherlands)

    Rees, P.H.; van der Gaag, N.L.; de Beer, J.A.A.; Heins, F.

    2012-01-01

    Europe is currently experiencing an ageing population and slowing population growth of both the total and working-age populations. These trends are likely to continue. Even though population ageing will affect all European regions, different regions will be affected in different ways. Even under

  3. Recruiting Youth in the College Market: Current Practices and Future Policy Options.

    Science.gov (United States)

    Kilburn, M. Rebecca, Ed.; Asch, Beth J., Ed.

    This publication explores the enlistment potential of college-market youth by examining the characteristics of the college-market population and the implications of these characteristics for designing effective recruiting policies. Chapter 1, "Introduction: Trends and Theoretical Considerations" (M. Rebecca Kilburn, Beth J. Asch),…

  4. [Interventional neuroradiology: current options].

    Science.gov (United States)

    Szikora, István; Marosfői, Miklós; Berentei, Zsolt; Gubucz, István

    2015-04-26

    Modern interventional neuroradiology has a leading role in the treatment of ischemic and hemorrhagic stroke, and it provides more and more important treatment options for degenerative diseases of the vertebral column and the management of correlated pain. During the last decades interventional neuroradiology has played a primary role in the treatment of intracranial berry aneurysms due to the continuous technical improvements. Ongoing studies proved superiority of mechanical stent-thrombectomy in acute proximal occlusion of cerebral arteries. Less invasive neurointerventional methods, such as vertebroplasty, are widely used in osteoporotic and neoplastic pathologic fractures of the vertebral bodies. These treatments should be performed in a specialized center by well trained physicians.

  5. Granting Concessions and Paying Ransoms to Terrorists: A Policy Options Analysis of the U.S. Policy on Hostage Recovery

    Science.gov (United States)

    2016-06-01

    CONCESSIONS AND PAYING RANSOMS TO TERRORISTS: A POLICY OPTIONS ANALYSIS OF THE U.S. POLICY ON HOSTAGE RECOVERY by Rodney Hyatt June 2016 Thesis... POLICY OPTIONS ANALYSIS OF THE U.S. POLICY ON HOSTAGE RECOVERY 5. FUNDING NUMBERS 6. AUTHOR(S) Rodney Hyatt 7. PERFORMING ORGANIZATION NAME(S...To answer this question, this thesis conducted a policy options analysis . Criteria were developed from the literature, and the current U.S. policy was

  6. Disc degeneration: current surgical options

    Directory of Open Access Journals (Sweden)

    C Schizas

    2010-10-01

    Full Text Available Chronic low back pain attributed to lumbar disc degeneration poses a serious challenge to physicians. Surgery may be indicated in selected cases following failure of appropriate conservative treatment. For decades, the only surgical option has been spinal fusion, but its results have been inconsistent. Some prospective trials show superiority over usual conservative measures while others fail to demonstrate its advantages. In an effort to improve results of fusion and to decrease the incidence of adjacent segment degeneration, total disc replacement techniques have been introduced and studied extensively. Short-term results have shown superiority over some fusion techniques. Mid-term results however tend to show that this approach yields results equivalent to those of spinal fusion. Nucleus replacement has gained some popularity initially, but evidence on its efficacy is scarce. Dynamic stabilisation, a technique involving less rigid implants than in spinal fusion and performed without the need for bone grafting, represents another surgical option. Evidence again is lacking on its superiority over other surgical strategies and conservative measures. Insertion of interspinous devices posteriorly, aiming at redistributing loads and relieving pain, has been used as an adjunct to disc removal surgery for disc herniation. To date however, there is no clear evidence on their efficacy. Minimally invasive intradiscal thermocoagulation techniques have also been tried, but evidence of their effectiveness is questioned. Surgery using novel biological solutions may be the future of discogenic pain treatment. Collaboration between clinicians and basic scientists in this multidisciplinary field will undoubtedly shape the future of treating symptomatic disc degeneration.

  7. Current management options for tyrosinemia

    Directory of Open Access Journals (Sweden)

    El-Shabrawi MH

    2013-03-01

    Full Text Available Mortada Hassan El-Shabrawi, Naglaa Mohamed KamalPediatric Hepatology, Faculty of Medicine, Cairo University, Cairo, EgyptAbstract: Hypertyrosinemia is observed in three inherited disorders of tyrosine metabolism. Hereditary Tyrosinemia Type I (HTT-I, or hepatorenal tyrosinemia, is an autosomal recessive disorder caused by mutation in the fumarylacetoacetate hydrolase (FAH gene. HTT-I is associated with severe involvement of the liver, kidneys, and central nervous system, and is due to toxic accumulation of metabolites of tyrosine, such as succinylacetone. HTT-I is the inborn error with the highest incidence of progression to hepatocellular carcinoma. Elevated succinylacetone, in dried filter paper blood samples, or in plasma or urine, is pathognomonic and diagnostic for HTT-I and is the most reliable neonatal screening method. Liver transplantation is the definitive management, but the need for this is markedly decreased by the combined dietary and drug management. A diet low in tyrosine and phenylalanine, plus nitisinone (2-[2-nitro-4-trifluoromethylbenzoyl]-1,3-cyclohexanedione (NCTB are considered the gold standard management options. Carnitine and 1,25-OH-vitamin D are adjuvant therapy. Strict follow up with succinylacetone level for monitoring of treatment should be done. Abdominal ultrasonography and abdominal computerized tomography scan or magnetic resonance imaging should also be done for surveillance of the possible development of hepatocellular carcinoma.Keywords: tyrosinemia, management, NTBC, hepatocellular carcinoma

  8. Cost allocation policy review: options and preferred alternatives

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-10-15

    This policy review of the consultation process on the electricity cost allocation issue is presented with specific cost allocation policy issues addressed herein, such as: the new microFIT rate, accounting changes and the transition to IFRS, and review of allocating costs to load displacement generation. This report gave the current situation for all these issues, previous work, issues, viable options for dealing with these issues and the preferred alternatives.

  9. First metatarsophalangeal joint arthrodesis: current fixation options.

    Science.gov (United States)

    Moon, Jared L; McGlamry, Michael C

    2011-04-01

    This article reviews the current literature on first metatarsophalangeal joint arthrodesis rates using various forms of fixation, as well as reviewing biomechanical studies comparing the strengths of the different fixation options that are available.

  10. China's Energy Situation and Relative Policy Options

    Institute of Scientific and Technical Information of China (English)

    Qiu Baoxing

    2005-01-01

    @@ Energy isa burning issue of the day in China. This paper analyses the crucial reasons of energy shortage and traditional consumption models in China. Drawing from the experiences of some developed countries, the paper suggests that China should recognize the energy crisis by learning from America's"smart growth project" with the aim of transforming the city planning model,improving the public transportation and launching a "green building" movement in the country. All the policy options in this paper focus on the construction area, just because urbanization is now running at a peak capacity in China. The objective of the paper is to identify the relative policy options and actions in the nearest future.

  11. China's Energy Situation and Relative Policy Options

    Institute of Scientific and Technical Information of China (English)

    Qiu; Baoxing

    2005-01-01

      Energy isa burning issue of the day in China. This paper analyses the crucial reasons of energy shortage and traditional consumption models in China. Drawing from the experiences of some developed countries, the paper suggests that China should recognize the energy crisis by learning from America's"smart growth project" with the aim of transforming the city planning model,improving the public transportation and launching a "green building" movement in the country. All the policy options in this paper focus on the construction area, just because urbanization is now running at a peak capacity in China. The objective of the paper is to identify the relative policy options and actions in the nearest future.……

  12. Commodities and Switzerland: Development Policy Challenges and Policy Options

    Directory of Open Access Journals (Sweden)

    Werner Thut

    2013-09-01

    Full Text Available EDITOR’S NOTEThis paper, written in December 2012, is a contribution to the ‘Policy Debate’ section of the International Development Policy. In this section, academics, policy makers and practitioners engage in a dialogue on global development challenges. Papers are copy-edited but not peer-reviewed. Instead, an initial thematic contribution is followed by critical comments and reactions from different stakeholders. This paper by Werner Thut is followed by reactions and analysis from a non-profit policy institute (Alexandra Gillies, Revenue Watch Institute, New York, ‘Crafting a Strategic Response to the Commodity-Development Conundrum’, a Southern scholar (Prof. Humberto Campodonico, Universidad Nacional Mayor de San Marcos, Lima ‘Going Beyond Transparency and Good Governance’ | ‘Más allá de la transparencia y una buena gobernanza’ and a representative of the trading sector (Stéphane Graber, Secretary General of Geneva Trading & Shipping Association – ‘Reassessing the Merchants’ Role in a Globalized Economy’.PAPER’S ABSTRACTSwitzerland is one of the world’s largest commodity trading hub. The author, senior policy adviser at the Swiss Agency for Development and Cooperation (SDC, reviews experiences and policy options related to commodity trading from a development policy perspective. While this sector has become of strategic importance to Switzerland’s economy, it also entails a number of risks. On the other hand, Swiss development cooperation efforts focus on several resource-rich countries, whose mineral and agricultural commodities are traded via Switzerland. How can Switzerland assist these countries to reap the benefits of their natural resource wealth? This paper looks at development policy aspects of commodity trading in relation to Swiss foreign and domestic policy. It examines ongoing policy debates in Switzerland and discusses development policy options.

  13. Expanding policy options for educating teenagers.

    Science.gov (United States)

    Stern, David

    2009-01-01

    David Stern argues that some basic features of the American high school must be modified if it is to serve all students successfully. He notes, for example, that only three-quarters of U.S. high school students graduate four years after beginning ninth grade and that the National Assessment of Educational Progress found no improvement in reading or mathematics for seventeen-year-olds between 1971 and 2004. The nation's system for educating teenagers, says Stern, seems to be stuck, despite the constant efforts of teachers and repeated waves of reform. Citing two widely accepted public purposes of educating teenagers-preparation for civic participation and for economic self-sufficiency-Stern proposes four new strategies to achieve those goals. He draws on empirical evidence suggesting that these are promising directions for research and policy, but acknowledges that existing studies provide only limited guidance. First, he says, schools should continue the current trend toward integrating educational options to provide young people with skills and experiences that pave the way to both college and careers. Second, states and districts should tie education funding not simply to the number of students attending school, but also to what young people learn, whether they graduate, and whether they find jobs or enroll in postsecondary education. Such a move, he argues, would encourage teaching and learning formats that use students' time more effectively. Third, more adults in addition to classroom teachers should be involved in educating teenagers. Other adults acting as academic advisers, learning coaches, student advocates, internship supervisors, mentors, and college counselors could help guide the education of teenagers inside and outside of school and provide some relief for the chronic shortage of teachers. Fourth, schools should expand the options for educating teenagers outside of geographically fixed schools. Combining improved Internet-based curriculum with

  14. Cannabis legalization with strict regulation, the overall superior policy option for public health.

    Science.gov (United States)

    Rehm, J; Fischer, B

    2015-06-01

    Cannabis is the most prevalently used drug globally, with many jurisdictions considering varying reform options to current policies to deal with this substance and associated harm. Three policy options are available: prohibition, decriminalization, and legalization, with prohibition currently the dominant model globally. This contribution gives reasons why legalization with strict regulation should be considered superior to other options with respect to public health in high income countries in North America.

  15. Global population trends and policy options.

    Science.gov (United States)

    Ezeh, Alex C; Bongaarts, John; Mberu, Blessing

    2012-07-14

    Rapid population growth is a threat to wellbeing in the poorest countries, whereas very low fertility increasingly threatens the future welfare of many developed countries. The mapping of global trends in population growth from 2005-10 shows four distinct patterns. Most of the poorest countries, especially in sub-Saharan Africa, are characterised by rapid growth of more than 2% per year. Moderate annual growth of 1-2% is concentrated in large countries, such as India and Indonesia, and across north Africa and western Latin America. Whereas most advanced-economy countries and large middle-income countries, such as China and Brazil, are characterised by low or no growth (0-1% per year), most of eastern Europe, Japan, and a few western European countries are characterised by population decline. Countries with rapid growth face adverse social, economic, and environmental pressures, whereas those with low or negative growth face rapid population ageing, unsustainable burdens on public pensions and health-care systems, and slow economic growth. Countries with rapid growth should consider the implementation of voluntary family planning programmes as their main policy option to reduce the high unmet need for contraception, unwanted pregnancies, and probirth reproductive norms. In countries with low or negative growth, policies to address ageing and very low fertility are still evolving. Further research into the potential effect of demographic policies on other social systems, social groups, and fertility decisions and trends is therefore recommended.

  16. Current and future treatment options in osteoporosis.

    LENUS (Irish Health Repository)

    Brewer, Linda

    2012-02-01

    PURPOSE: The incidence of osteoporosis-related fractures will increase substantially over the coming decades as the population ages globally. This has important economic and public health implications, contributing substantially to morbidity and excess mortality in this population. METHODS: When prescribing for older patients the effectiveness profile of drugs needs to be balanced against their tolerability in individual patients. RESULTS: Currently we have good anti-fracture data to support the use of many available anti-resorptive and anabolic drugs including bisphosphonates, strontium ranelate and recombinant human parathyroid hormone. We also have evidence to demonstrate the importance of calcium and vitamin D repletion in these patients. However, in recent years our understanding of normal bone physiology and the mechanisms underlying the development of osteoporosis has significantly advanced and this has led to the development of new therapies. Novel agents, particularly denosumab, but also inhibitors of cathepsin K and anabolic agents that act on Wnt signalling, will increase the therapeutic options for clinicians in the coming years. CONCLUSION: This review discusses the evidence supporting the use of currently available treatment options for osteoporosis and potential future advances in drug therapy. Particular consideration should be given when prescribing for certain older patients who have issues with compliance or tolerance and also in those with co-morbidities or levels of frailty that may restrict the choice of therapy. Understanding the evidence for the benefit and possible harm of osteoporosis treatments is critical to appropriate management of this patient population.

  17. Current Treatment Options in Vestibular Migraine

    Science.gov (United States)

    Obermann, Mark; Strupp, Michael

    2014-01-01

    Approximately 1% of the general population in western industrialized countries suffers from vestibular migraine. However, it remains widely unknown and often under diagnosed despite the recently published diagnostic criteria for vestibular migraine. Treatment trials that specialize on vestibular migraine are scarce and systematic randomized controlled clinical trials are now only emerging. This review summarizes the knowledge on the currently available treatment options that were tested specifically for vestibular migraine and gives an evidence-based, informed treatment recommendation with all its limitations. To date only two randomized controlled treatment trials provide limited evidence for the use of rizatriptan and zolmitriptan for the treatment of vestibular migraine attacks because of methodological shortcomings. There is an ongoing multicenter randomized placebo-controlled trial testing metoprolol 95 mg vs. placebo (PROVEMIG-trial). Therefore, the therapeutic recommendations for the prophylactic treatment of vestibular migraine are currently widely based on the guidelines of migraine with and without aura as well as expert opinion. PMID:25538676

  18. Policy Options for Effective REDD+ Implementation in Indonesia

    DEFF Research Database (Denmark)

    Saito-Jensen, Moeko; Sikor, Thomas; Kurniawan, Y.

    2015-01-01

    Indonesia, which contains the third-largest area of tropical forest in the world, is currently exploring policy options for the effective implementation of REDD+, the global initiative to reduce emissions from deforestation and forest degradation. This article analyses the major questions regarding...... degradation, due to high opportunity costs. REDD+ finance may be more effectively used to reward small-scale dispersed activities that enhance carbon stocks, such as those already happening under Indonesia's community nursery programme. The analysis indicates the necessity for forest tenure reform...

  19. Policy Options for Effective REDD+ Implementation in Indonesia

    DEFF Research Database (Denmark)

    Saito-Jensen, Moeko; Sikor, Thomas; Kurniawan, Y.;

    2015-01-01

    Indonesia, which contains the third-largest area of tropical forest in the world, is currently exploring policy options for the effective implementation of REDD+, the global initiative to reduce emissions from deforestation and forest degradation. This article analyses the major questions regarding...... the effective distribution of benefits on the basis of three village case studies in Kutai Barat district in the province of East Kalimantan. The case studies demonstrate that companies are unlikely to take up compensation payments for stopping large-scale activities that cause deforestation and forest...

  20. Policy options for effective REDD+ implementation in Indonesia

    DEFF Research Database (Denmark)

    Saito, Moeko; Sikor, T.; Kurniawan, Y.

    2015-01-01

    Indonesia, which contains the third-largest area of tropical forest in the world, is currently exploring policy options for the effective implementation of REDD+, the global initiative to reduce emissions from deforestation and forest degradation. This article analyses the major questions regarding...... degradation, due to high opportunity costs. REDD+ finance may be more effectively used to reward small-scale dispersed activities that enhance carbon stocks, such as those already happening under Indonesia's community nursery programme. The analysis indicates the necessity for forest tenure reform...

  1. Policy Options for Effective REDD+ Implementation in Indonesia

    DEFF Research Database (Denmark)

    Saito-Jensen, Moeko; Sikor, Thomas; Kurniawan, Y.

    2015-01-01

    Indonesia, which contains the third-largest area of tropical forest in the world, is currently exploring policy options for the effective implementation of REDD+, the global initiative to reduce emissions from deforestation and forest degradation. This article analyses the major questions regarding...... degradation, due to high opportunity costs. REDD+ finance may be more effectively used to reward small-scale dispersed activities that enhance carbon stocks, such as those already happening under Indonesia's community nursery programme. The analysis indicates the necessity for forest tenure reform...

  2. GATS Mode 4 Negotiation and Policy Options

    Directory of Open Access Journals (Sweden)

    Kil-Sang Yoo

    2004-06-01

    Full Text Available This study reviews the characteristics and issues of GATS Mode 4 and guesses the effects of Mode 4 liberalization on Korean economy and labor market to suggest policy options to Korea. Mode 4 negotiation started from the trade perspective, however, since Mode 4 involves international labor migration, it also has migration perspective. Thus developed countries, that have competitiveness in service sector, are interested in free movement of skilled workers such as intra-company transferees and business visitors. On the other hand, developing countries, that have little competitiveness in service sector, are interested in free movement of low-skilled workers. Empirical studies predict that the benefits of Mode 4 liberalization will be focused on developed countries rather than developing countries. The latter may suffer from brain drain and reduction of labor supply. Nevertheless developed countries are reluctant to Mode 4 negotiation because they can utilize skilled workers from developing countries by use of their own temporary visa programs. They are interested in Mode 4 related with Mode 3 in order to ease direct investment and movement of natural persons to developing countries. Regardless of the direction of a single undertaking of Mode 4 negotiation, the net effects of Mode 4 liberalization on Korean economy and labor market may be negative. The Korean initial offer on Mode 4 is the same as the UR offer. Since Korean position on Mode 4 is most defensive, it is hard to expect that Korean position will be accepted as the single undertaking of Mode 4 negotiation. Thus Korea has to prepare strategic package measures to minimize the costs of Mode 4 liberalization and improve competitiveness of service sector.

  3. Current and emerging options for taxol production.

    Science.gov (United States)

    Li, Yi; Zhang, Guojian; Pfeifer, Blaine A

    2015-01-01

    Paclitaxel (trademark "Taxol") is a plant-derived isoprenoid natural product that exhibits potent anticancer activity. Taxol was originally isolated from the Pacific yew tree in 1967 and triggered an intense scientific and engineering venture to provide the compound reliably to cancer patients. The choices available for production include synthetic and biosynthetic routes (and combinations thereof). This chapter focuses on the currently utilized and emerging biosynthetic options for Taxol production. A particular emphasis is placed on the biosynthetic production hosts including macroscopic and unicellular plant species and more recent attempts to elucidate, transfer, and reconstitute the Taxol pathway within technically advanced microbial hosts. In so doing, we provide the reader with relevant background related to Taxol and more general information related to producing valuable, but structurally complex, natural products through biosynthetic strategies.

  4. Climate - Options for broadening climate policy

    NARCIS (Netherlands)

    Aerts JCJH; Asselt H van; Bakker SJA; Bayangos V; Beers C van; Berk MM; Biermann F; Bouwer LM; Bree L van; Coninck HC de; Dorland K; Elzen ME den; Gupta J; Heemst J van; Jansen JC; Kok MTJ; Nabuurs GJ; Veraert J; Verhagen A; Kok MTJ; Coninck HC de; ECN; KMD

    2005-01-01

    In this study ways are explored to increase the policy coherence between the climate regime and a selected number of climate relevant policy areas, by adding a non-climate policy track to national and international climate strategies. The report assesses first the potential, synergies and trade-offs

  5. Current treatment options in vestibular migraine

    Directory of Open Access Journals (Sweden)

    Mark eObermann

    2014-12-01

    Full Text Available Approximately 1% of the general population in western industrialized countries suffers from vestibular migraine. However, it remains widely unknown and often under diagnosed even despite the recently published diagnostic criteria for vestibular migraine. Treatment trials that specialize on vestibular migraine are scarce and systematic randomized controlled clinical trials are only now emerging.This review summarizes the knowledge on the currently available treatment options that were tested specifically for vestibular migraine and gives an evidence-based, informed treatment recommendation with all its limitations.To date only two randomized controlled treatment trials provide limited evidence for the use of rizatriptan and zolmitriptan for the treatment of vestibular migraine attacks because of methodological shortcommings. There is an on-going a multicenter randomized placebo-controlled trial testing metoprolol 95 mg vs. placebo (PROVEMIG-trial. Therefore, the therapeutic recommendations for the prophylactic treatment of vestibular migraine are currently widely based on the guidelines of migraine with and without aura as well as expert opinion.

  6. Energy policy options for Illinois. Proceedings. [26 papers

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    Twenty-six papers presented at the Fifth Annual Oil Illinois Energy Conference are categorized into five sections, namely: An overview of U.S. and Illinois Energy Policy; Energy Policy; Conservation--Solar--Biomass and Solid Wastes; Energy Policy; Petroleum and Natural Gas; Energy Policy; Coal and Electric Utilities; and Economic and Consumer Concerns. One paper, A Perspective on Long-Range Nuclear Energy Options, by William O. Harms has previously appeared in EAPA 4: 1364. (MCW)

  7. How federalism shapes public health financing, policy, and program options.

    Science.gov (United States)

    Ogden, Lydia L

    2012-01-01

    In the United States, fiscal and functional federalism strongly shape public health policy and programs. Federalism has implications for public health practice: it molds financing and disbursement options, including funding formulas, which affect allocations and program goals, and shapes how funding decisions are operationalized in a political context. This article explores how American federalism, both fiscal and functional, structures public health funding, policy, and program options, investigating the effects of intergovernmental transfers on public health finance and programs.

  8. Epstein-Barr infection: Current treatment options

    Directory of Open Access Journals (Sweden)

    Abubakar Yaro

    2013-01-01

    Full Text Available Epstein-Barr virus is one of the causes of known human cancers such as PLTD, BL and XLP. It is persistent in about 90% of the global population. Prevalent antiviral agents are not effective. A systematic review was undertaken to discuss current treatment options available for EBV infection. A search was made of PubMed to identify relevant papers published from 2000 to 2010 using various search indexes. The review is based on 11 articles included in the study. The result showed that there is no studies which analyzed antiviral agents in EBV infection. Combinational therapy using antiviral agents, immunotherapy and anticancer agents should be considered while antibiotic regimen should be considered to take care of any sepsis. Resistance to antiviral agents especially cross-resistance is burden in EBV infection Studies should be undertaken to evaluate resistance pattern in EBV infection. To assess the efficacy of EBV therapeutics. Viral load using molecular techniques should be used as biomarker of efficacy.

  9. Renewable energy policy evaluation using real option model - The case of Taiwan

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.-C., E-mail: n4895102@mail.ncku.edu.t [Department of Resources Engineering, National Cheng Kung University, Tainan City 701, Taiwan (China); Shih, L.-H., E-mail: lhshih@mail.ncku.edu.t [Department of Resources Engineering, National Cheng Kung University, Tainan City 701, Taiwan (China)

    2010-09-15

    This study presents a policy benefit evaluation model that integrates cost efficiency curve information on renewable power generation technologies into real options analysis (ROA) methods. The proposed model evaluates quantitatively the policy value provided by developing renewable energy (RE) in the face of uncertain fossil fuel prices and RE policy-related factors. The economic intuition underlying the policy-making process is elucidated, while empirical analysis illustrates the option value embedded in the current development policy in Taiwan for wind power. In addition to revealing the benefits that RE development provides when considering real options, analytical results indicate that ROA is a highly effective means of quantifying how policy planning uncertainty including managerial flexibility influences RE development. In addition to assessing the policy value of current RE development policy, this study also compares policy values in terms of internalized external costs and varying feed-in tariff (FIT). Simulation results demonstrate that the RE development policy with internalized CO{sub 2} emission costs is appropriate policy planning from sustainability point of view. Furthermore, relationship between varying FIT and policy values can be shown quantitatively and appropriate FIT level could be determined accordingly.

  10. EU policy options for climate and energy beyond 2020

    Energy Technology Data Exchange (ETDEWEB)

    Koelemeijer, R.; Ros, J.; Notenboom, J.; Boot, P. [Netherlands Environmental Assessment Agency PBL, Den Haag (Netherlands); Groenenberg, H.; Winkel, T. [Ecofys, Utrecht (Netherlands)

    2013-05-15

    In 2009, the EU climate and energy package with targets for 2020 (the so-called 20-20-20 targets) were formulated. For the period after 2020, however, there are no legally binding targets at the EU level, except for a decreasing ETS cap which will not be sufficient in light of the ambition for 2050. This leads to uncertainty for market players, as project lead times are long and high upfront investments need to deliver returns well beyond 2020. In its Green Paper on a 2030 framework for climate and energy policies, the European Commission recognised the need for clarity regarding the post-2020 policy framework. Currently under discussion is whether the approach for 2020 should be continued towards 2030 in the form of three more stringent targets or that other approaches would be more appropriate. Within this context, the Dutch Government asked PBL Netherlands Environmental Assessment Agency and Ecofys for advice. PBL and Ecofys have subsequently analysed possible options for an EU policy framework for 2030 that will steer towards a low-carbon economy by 2050 in a cost-effective way.

  11. Radiation indicator options for environmental policy

    CERN Document Server

    Pruppers, M J M

    2002-01-01

    It has proven impossible to create an indicator capable of showing the state of the art in a single figure so as to determine the progress made in the 'radiation component' of environmental policy from the trends indicated. This is the conclusion following an investigation requested by the Ministry of Housing, Spatial Planning and the Environment in the framework of the environmental theme 'dispersion of radioactive substances and ionising radiation' to develop a radiation indicator comparable to the indicators for proprietary substances and pesticides. The most important reasons for failing to develop this indicator lie in the absence of both suitable policy targets and data for the calculations necessary for the indicator. Substituting policy targets with reference emissions, reference concentrations and reference doses would make it possible to define indicators for radiation protection. Here, environmental pressure indicators are proposed for nuclear installations and the process industry. The environment...

  12. Danish Telecommunications: Keeping the Policy Options Open

    DEFF Research Database (Denmark)

    Henten, Anders; Wulff, Thomas

    1996-01-01

    In recent years Danish telecommunications policy has gone through a marked change in emphasis, Tele Danmark, formed only 6 years ago as the national operator in order to strengthen the Danish telecom industry, has come under pressure in the present liberalization. This article discusses Tele...... Danmark's situation and future possibilities and presents background information on the new Danish telecommunications legislation, the present Danish telecommunications market, and Tele Danmark's strategies. Copyright (C) 1996 Elsevier Science Ltd...

  13. Green Building Policy Options for New Orleans

    Energy Technology Data Exchange (ETDEWEB)

    Doris, E.

    2011-09-01

    This document is adapted from a memo and report delivered to the City Council of New Orleans, the office of the Mayor of New Orleans, the Chairperson of the Citizen Stakeholders Group (New Orleans Energy Task Force) and the U.S. Department of Energy (DOE) Project Officer in 2008. The report outlines ideas for and potential impacts of various green building policies in New Orleans in the years following Hurricane Katrina.

  14. World Energy Outlook - 2050: Policy Options

    Energy Technology Data Exchange (ETDEWEB)

    Ghouri, Salman Saif

    2007-07-01

    The paper analyzes the historical trends, resource distribution and forecasts the regional total primary energy consumption (TPEC) to 2050. The purpose is to provide a most probable path so that appropriate policies can be made to enhance/slowdown the energy consumption without hampering economic growth. Global TPEC is most likely to reach 763-1259 Quadrillion Btu (QBtu) to 2050 with reference case trending between and stood at 978 QBtu. By 2050 the equation of TPEC is expected to be tilted in favor of developing countries when their share is increased from 47 percent in 2003 to 59 percent. Asia developing region becomes the largest consumer of TPEC; however on per capita basis it remains the lowest after Africa. The forecast gives some guidance to policy makers. Which policy measures should be taken to ensure availability of predicted level of energy resources? How should we mobilize sizeable investment to increase the expected production/capacity/logistic both in the producing and consuming countries? Simultaneously, what strategic measures should be taken: to improve energy efficiency/conservation, development/promotion of renewable sources of energies and check population growth to downward shift the probable TPEC path without compromising economic growth, productivity and quality of life? (auth)

  15. A Practical Method of Policy Analysis by Simulating Policy Options

    Science.gov (United States)

    Phelps, James L.

    2011-01-01

    This article focuses on a method of policy analysis that has evolved from the previous articles in this issue. The first section, "Toward a Theory of Educational Production," identifies concepts from science and achievement production to be incorporated into this policy analysis method. Building on Kuhn's (1970) discussion regarding paradigms, the…

  16. Lagophthalmos after facial palsy: current therapeutic options.

    Science.gov (United States)

    Vásquez, Luz María; Medel, Ramón

    2014-01-01

    As the facial nerve carries sensory, motor and parasympathetic fibres involved in facial muscle innervation, facial palsy results in functional and cosmetic impairment. It can result from a wide variety of causes like infectious processes, trauma, neoplasms, autoimmune diseases, and most commonly Bell's palsy, but it can also be of iatrogenic origin. The main ophthalmic sequel is lagophthalmos. The increased surface exposure increases the risk of keratitis, corneal ulceration, and potentially loss of vision. Treatment options are wide; some are temporary, some permanent. In addition to gold standard and traditional therapies and procedures, new options are being proposed aiming to improve not only lagophthalmos but also the quality of life of these patients. © 2014 S. Karger AG, Basel.

  17. Cost effectiveness of GHG mitigation options and policy implication

    Energy Technology Data Exchange (ETDEWEB)

    Lim, K. S. [Korea Institute for Industrial Economics and Trade, Seoul (Korea, Republic of)

    1998-04-01

    This paper represents the summary findings and conclusions of several studies implemented about microeconomics and macroeconomics marginal costs of GHG abatement policies. Financial, economic, and, where possible, environmental microeconomics costs of reducing GHGs are estimated by a World Bank team. Six energy-related CO{sub 2} mitigation policy options are applied to estimate the macroeconomics costs of GHG emission reduction, the macroeconomics impacts on the Chinese economy. In terms of policy, conservation is a better option to cope with a restrictive mitigation constraint, assuming a developing country can achieve planned energy-saving targets. Without a CO{sub 2} emission constraint or with less restrictive CO{sub 2} emission constraints, however, the simulation results indicate that a conservation strategy may be less attractive than fuel substitution in a developing country, mainly due to the economic dampening effect of reduced production in the energy sectors. This finding suggests that an often-cited costless or negative-cost energy conservation policy may not be a better option when a less restrictive mitigation target is in force. This does not mean that the potential for energy efficiency improvements in a developing country is not worthwhile, but that the overall macroeconomics impacts should be considered before implementing the policy option. (author). 9 refs., 3 figs., 3 tabs.

  18. Reconciling biofuels, sustainability and commodities demand. Pitfalls and policy options

    Energy Technology Data Exchange (ETDEWEB)

    Uslu, A.; Bole, T.; Londo, M. [ECN Policy Studies, Petten (Netherlands); Pelkmans, L. [VITO, Mol (Belgium); Berndes, G. [Chalmers University, Gothenburg (Sweden); Prieler, S.; Fischer, G. [International Institute for Applied Systems Analysis IIASA, Laxenburg (Austria); Cueste Cabal, H. [CIEMAT, Madrid (Spain)

    2010-06-15

    Increasing fossil fuel prices, energy security considerations and environmental concerns, particularly concerning climate change, have motivated countries to explore alternative energy sources including biofuels. Global demand for biofuels has been rising rapidly due to biofuel support policies established in many countries. However, proposed strong links between biofuels demand and recent years' high food commodity prices, and notions that increasing biofuels production might bring about serious negative environmental impacts, in particularly associated with the land use change to biofuel crops, have shifted public enthusiasm about biofuels. In this context, the ELOBIO project aims at shedding further light to these aspects of biofuel expansion by collecting and reviewing the available data, and also developing strategies to decrease negative effects of biofuels while enabling their positive contribution to climate change, security of supply and rural development. ELOBIO considers aspects associated with both 1st and 2nd generation biofuels, hence analyses effects on both agricultural commodity markets and lignocellulosic markets. This project, funded by the Intelligent Energy Europe programme, consists of a review of current experiences with biofuels and other renewable energy policies and their impacts on other markets, iterative stakeholder-supported development of low-disturbing biofuels policies, model supported assessment of these policies' impacts on food, feed and lignocellulosic markets, and finally an assessment of the effects of selected optimal policies on biofuels costs and potentials. Results of the ELOBIO study show that rapid biofuel deployment without careful monitoring of consequences and implementation of mitigating measures risks leading to negative consequences. Implementing ambitious global biofuel targets for 2020, based on current 1st generation technologies, can push international agricultural commodity prices upwards and

  19. Post-Unified Korean Foreign Policy Options: Regional Implications

    Science.gov (United States)

    2002-09-01

    Korean War, the U.S. security policy toward Korea has been instrumental in promoting peace and stability on the peninsula. The strong defense alliance...request the removal of United States troops from the Korean peninsula and the nullification of the United States-South Korea Mutual Defense Treaty...security alliance. However, after the elimination of the North Korean threat, a unified Korea will be able to redefine its foreign policy options

  20. Compulsory Annuitisation: A Policy Option for Australia?

    Directory of Open Access Journals (Sweden)

    Taleitha O'Meara

    2013-09-01

    Full Text Available Abstract The use of lifetime annuities is one obvious candidate to deliver guaranteed income in retirement. This paper quantifies the marginal increase in income to a single male when compelled to purchase a lifetime annuity from superannuation savings, compared to the current position of voluntary annuitisation in the Australian market. It is found that significant increases in average income are possible under compulsion, with an associated decrease in the cost of the age pension. Future mortality is shown to be the key area of sensitivity. The critical importance of future age pension eligibility rules being adaptable in line with mortality changes is demonstrated.

  1. CURRENT OPTIONS FOR SURGICAL TREATMENT OF GLAUCOMA.

    Science.gov (United States)

    Stefan, Cornel; Batras, Mehdi; Iliescu Daniela, Adriana; Timaru Cristina, Mihaela; De Simone, Algerino; Hosseini-Ramhormozi, Jalaladin

    2015-01-01

    The purpose of this study is to review current surgical treatment and new and better alternatives for patients with glaucoma. Glaucoma refers to a group of related eye disorders that have in common an optic neuropathy associated with visual function loss. It is one of the leading causes of irreversible blindness worldwide. Optic nerve damage and glaucoma-related vision loss can be prevented or limited by early diagnosis and treatment. Surgery offers a better control of the intraocular pressure then medical therapy. Nowadays, research continues for improving current surgical alternatives for treatment.

  2. Transport, environment and health in central and Eastern Europe. State of affairs and policy options

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    The report provides a review of the current state of affairs and development trends in the transport sector in Central and Eastern Europe including the associated environmental and health effects. Focus in the report is on the challenges and policy options for counteracting the negative effects from transport as well as integrating environmental and health aspects in transport policies. The report is undertaken as a desk study supplemented by two case studies in the Czech Republic and Bulgaria. (au)

  3. Narcolepsy: current treatment options and future approaches

    Directory of Open Access Journals (Sweden)

    Michel Billiard

    2008-06-01

    Full Text Available Michel BilliardDepartment of Neurology, Gui de Chauliac Hospital, Montpellier, FranceAbstract: The management of narcolepsy is presently at a turning point. Three main avenues are considered in this review: 1 Two tendencies characterize the conventional treatment of narcolepsy. Modafinil has replaced methylphenidate and amphetamine as the first-line treatment of excessive daytime sleepiness (EDS and sleep attacks, based on randomized, double blind, placebo-controlled clinical trials of modafinil, but on no direct comparison of modafinil versus traditional stimulants. For cataplexy, sleep paralysis, and hypnagogic hallucinations, new antidepressants tend to replace tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs in spite of a lack of randomized, double blind, placebo-controlled clinical trials of these compounds; 2 The conventional treatment of narcolepsy is now challenged by sodium oxybate, the sodium salt of gammahydroxybutyrate, based on a series of randomized, double-blind, placebo-controlled clinical trials and a long-term open label study. This treatment has a fairly good efficacy and is active on all symptoms of narcolepsy. Careful titration up to an adequate level is essential both to obtain positive results and avoid adverse effects; 3 A series of new treatments are currently being tested, either in animal models or in humans, They include novel stimulant and anticataplectic drugs, endocrine therapy, and, more attractively, totally new approaches based on the present state of knowledge of the pathophysiology of narcolepsy with cataplexy, hypocretine-based therapies, and immunotherapy.Keywords: narcolepsy, treatment, conventional drugs, modafinil, sodium oxybate, future treatments

  4. The Distributional Impact of Social Security Policy Options.

    Science.gov (United States)

    Couch, Kenneth A; Reznik, Gayle L; Tamborini, Christopher R; Iams, Howard M

    2017-01-01

    Using microsimulation, we estimate the effects of three policy proposals that would alter Social Security's eligibility rules or benefit structure to reflect changes in women's labor force activity, marital patterns, and differential mortality among the aged. First, we estimate a set of options related to the duration of marriage required to receive divorced spouse and survivor benefits. Second, we estimate the effects of an earnings sharing proposal with survivor benefits, in which benefits are based entirely on earned benefits with spouses sharing their earnings during years of marriage. Third, we estimate the effects of adjusting benefits to reflect the increasing differential life expectancy by lifetime earnings. The results advance our understanding of the distributional effects of these alternative policy options on projected benefits and retirement income, including poverty and supplemental poverty status, of divorced and widowed women aged 60 or older in 2030.

  5. Fighting Forest Fires - An Assessment of Policy Options in Indonesia

    OpenAIRE

    Luthfi Fatah; Udiansyah

    2010-01-01

    Uncontrolled forest fires are one of the key causes of habitat destruction in Indonesia. The haze they produce causes significant pollution problems for people in the country and in surrounding nations. This study has highlighted the root causes of the fires and assessed a range of potential new policy options to improve the situation. The study finds that the weak enforcement of forest conservation rules and regulations is a key problem and that this is caused by wide range of resource and i...

  6. Comparing Clean Water Act Section 316(b Policy Options

    Directory of Open Access Journals (Sweden)

    John Kadvany

    2002-01-01

    Full Text Available This paper develops a comparative framework for policy proposals involving fish protection and Section 316(b of the Clean Water Act (CWA. Section 316(b addresses the impingement and entrainment of fish by cooling-water intake structures used principally by steam electric power plants. The framework is motivated by examining the role of adverse environmental impacts (AEIs in the context of Section 316(b decision making. AEI is mentioned in Section 316(b, but not defined. While various AEI options have been proposed over the years, none has been formalized through environmental regulations nor universally accepted. Using a multiple values approach from decision analysis, AEIs are characterized as measurement criteria for ecological impacts. Criteria for evaluating AEI options are identified, including modeling and assessment issues, the characterization of ecological value, regulatory implementation, and the treatment of uncertainty. Motivated by the difficulties in defining AEI once and for all, a framework is introduced to compare options for 316(b decision making. Three simplified policy options are considered, each with a different implicit or explicit AEI approach: (1 a technology-driven rule based on a strict reading of the 316(b regulatory text, and for which any impingement and entrainment count as AEI, (2 a complementary, open-ended risk-assessment process for estimating population effects with AEI characterized on a site-specific basis, and (3 an intermediate position based on proxy measures such as specially constructed definitions of littoral zone, sensitive habitat, or water body type. The first two proposals correspond roughly to responses provided, respectively, by the Riverkeeper environmental organization and the Utility Water Act Group to the U.S. Environmental Protection Agency (EPA’s proposed 316(b new facilities rule of August 2000; the third example is a simplified form of the EPA’s proposed August 2000 new facilities

  7. Options for sustainable passenger transport: an assessment of policy choices

    NARCIS (Netherlands)

    Vleugel, J.M.; Rienstra, S.A.

    1995-01-01

    If the current trends in transport are not changed, a sustainable transport system is not feasible. In order to achieve such a state, new technologiesmay be an interesting option. In this context several success and failure factors for the introduction of new technologies are analyzed in this articl

  8. Policy Overview and Options for Maximizing the Role of Policy in Geothermal Electricity Development

    Energy Technology Data Exchange (ETDEWEB)

    Doris, Elizabeth [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kreycik, Claire [National Renewable Energy Lab. (NREL), Golden, CO (United States); Young, Katherine [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2009-09-01

    This research explores the effectiveness of the historical and current body of policies in terms of increased geothermal electricity development. Insights are provided into future policies that may drive the market to optimize development of available geothermal electricity resources.

  9. Real options analysis for land use management: Methods, application, and implications for policy.

    Science.gov (United States)

    Regan, Courtney M; Bryan, Brett A; Connor, Jeffery D; Meyer, Wayne S; Ostendorf, Bertram; Zhu, Zili; Bao, Chenming

    2015-09-15

    Discounted cash flow analysis, including net present value is an established way to value land use and management investments which accounts for the time-value of money. However, it provides a static view and assumes passive commitment to an investment strategy when real world land use and management investment decisions are characterised by uncertainty, irreversibility, change, and adaptation. Real options analysis has been proposed as a better valuation method under uncertainty and where the opportunity exists to delay investment decisions, pending more information. We briefly review the use of discounted cash flow methods in land use and management and discuss their benefits and limitations. We then provide an overview of real options analysis, describe the main analytical methods, and summarize its application to land use investment decisions. Real options analysis is largely underutilized in evaluating land use decisions, despite uncertainty in policy and economic drivers, the irreversibility and sunk costs involved. New simulation methods offer the potential for overcoming current technical challenges to implementation as demonstrated with a real options simulation model used to evaluate an agricultural land use decision in South Australia. We conclude that considering option values in future policy design will provide a more realistic assessment of landholder investment decision making and provide insights for improved policy performance. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. [Current options for percutaneous endoscopic access to the digestive tract

    NARCIS (Netherlands)

    Romkens, T.E.H.; Jong, D.J. de; Kristinsson, J.O.; Wanten, G.J.A.

    2008-01-01

    Four patients, aged 67, 52, 56 and 64 years, respectively, undergoing percutaneous colostomy or jejunostomy are presented to illustrate current options for percutaneous endoscopic access to the digestive tract. The first patient had Parkinson's disease and required percutaneous jejunostomy for conti

  11. Non-OPEC Oil Supply: Economics and Energy Policy Options

    Energy Technology Data Exchange (ETDEWEB)

    Mourik, Maarten van [Paris (France); Shepherd, Richard K. [Perpignan (France)

    2003-07-01

    shift in investment strategy than the lure of better profits. However strong the evidence of an imminent peaking of offshore and perhaps total non-OPEC oil supply, the reality is that governments will not readily recognise a 'bad news' scenario that will inevitably tarnish their own political image. It follows that a global and permanent threat to their economies and energy security from a shortfall in oil supply outside the Persian Gulf and central Asia will only become a policy assumption if viable and attractive energy policy options are available. If there is single focus to any energy supply threat, then it is the market for transportation fuels, the strongest growing segment of the energy market and the only segment of the energy market where there are no significant alternatives already on offer. The second half of this paper suggests that there are industrial or financial obstacles to the large-scale introduction of fuels other than current specification gasoline and diesel. Almost all the current initiatives to explore and encourage alternative fuels address a long-term future in which fuel cells or hydrogen or 'California-clean' liquids replace the current fuels at the pump. Further, most research concentrates on the environmental aspects of the alternatives rather than their large-scale industrial availability. Yet the hard reality is that any solution to the global oil supply dilemma must be large scale (at least 10% of the total market for transportation fuels) and soon, which means within a decade. The technical facts are that fuels such as ethanol and methanol can be produced in very large volumes and delivered to the consumer without any significant change to the huge infrastructure constituted by the global internal combustion engine manufacturing industry and by the existing fuel distribution networks. This large, immediate and obvious opportunity has not been grasped so far for the excellent reason that the status quo is profitable

  12. Options Procurement Policy for Option Contracts with Supply and Spot Market Uncertainty

    Directory of Open Access Journals (Sweden)

    Weili Xue

    2014-01-01

    Full Text Available Supplier’s reliability is a major issue in procurement management. In this paper, we establish a decision making model from the perspective of the firm who will procure from the multiple suppliers and the spot markets. The suppliers are unreliable and provide different types of option-type supply contracts which should be made before demand realization, while the spot market can only be used after demand realization and has both the price and liquidity risks. We establish the optimal portfolio policies for the firm with conditions to find the qualified suppliers. By defining a new function which contains the demand risk, the supplier’s risk, and the liquidity risk, we find that the optimal policy is to allocate different curves of this function to different suppliers. We also study some special cases to derive some managerial insights. At last, we numerically study how the various risks affect the choice of suppliers and the value of the option contract.

  13. Current adaptation measures and policies

    Science.gov (United States)

    Geoff Roberts; John A. Parrotta; Anita. Wreford

    2009-01-01

    As stated in earlier chapters, the possible impacts of climate change on forests and the forest sector are considerable, and many impacts have already been observed. As forest conditions change, there is an inherent need to change management and policy measures to minimise negative impacts and to exploit the benefits derived from climate change. This chapter highlights...

  14. Soldier-Portable Battery Supply: Foreign Dependence and Policy Options

    Science.gov (United States)

    2014-01-01

    manufacture within Asia represents too great a supply-chain risk and thus the current policy should be changed . How this Study Was conducted The RAND...private firm, the Sociedad Quimica y Minera (SQM) de Chile. Across the border in Bolivia, the Salar de Uyuni, which is the largest salt flat in the...manufactured cells, compared with the cur- rent batteries containing Asian-manufactured cells. This would require a change from the current DLA practice of

  15. Policy Overview and Options for Maximizing the Role of Policy in Geothermal Electricity Development

    Energy Technology Data Exchange (ETDEWEB)

    Doris, E.; Kreycik, C.; Young, K.

    2009-09-01

    Geothermal electricity production capacity has grown over time because of multiple factors, including its renewable, baseload, and domestic attributes; volatile and high prices for competing technologies; and policy intervention. Overarching federal policies, namely the Public Utilities Regulatory Policies Act (PURPA), provided certainty to project investors in the 1980s, leading to a boom in geothermal development. In addition to market expansion through PURPA, research and development policies provided an investment of public dollars toward developing technologies and reducing costs over time to increase the market competitiveness of geothermal electricity. Together, these efforts are cited as the primary policy drivers for the currently installed capacity. Informing policy decisions depends on the combined impacts of policies at the federal and state level on geothermal development. Identifying high-impact suites of policies for different contexts, and the government levels best equipped to implement them, would provide a wealth of information to both policy makers and project developers.

  16. Surface technologies 2006 - Alternative energies and policy options

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Lars [University of British Columbia, Vancouver (Canada). Department of Materials Engineering

    2007-12-15

    Surfaces are the immediate contact between anything in our world. Literally, every industry utilizes coatings and surface modifications in order to create surfaces tailored to specific needs, protect underlying substrates, or modify their behavior. Surface and coating technologies are essential to a large variety of different industrial sectors, including transportation, manufacturing, food and biomedical engineering, energy, resources, and materials science and technology. The present paper explains the limitations for alternative energy technologies, with a focus on fuel cell technology development and the alternative energy sector, based on the outcomes of presentations and facilitated discussion groups during a Canadian national workshop series. Options for technological improvements of alternative energy systems are presented in combination with national and international policy choices, which could positively influence research and development in the alternative energy sector. (author)

  17. The Current Cluster Policy: Essence and Characteristics

    Directory of Open Access Journals (Sweden)

    Onipko Tetiana A.

    2017-05-01

    Full Text Available The article is aimed at defining essence of the current cluster policy and its characteristics. It was specified that, in the process of developing and implementing regional, innovation and entrepreneurial policies, many governments drew attention to the clustering of economy as a means of achieving a high level of regional and national competitiveness. The current cluster policy needs to be integrated, that is, to unify different policies, programs, and means. One of the characteristics of the current cluster policy is its orientation towards public-private partnership. The efficient form of such a partnership is cluster organizations. The author’s vision of the current cluster policy is that both the State and the private sector should be parties to it. Emphasis has been placed on the need to support in Ukraine, at the State level, the innovation clusters that facilitate modernization of the existing economic sectors by combining the traditions and the challenges of modernity. It has been concluded that social organizations could be involved in the process of development and implementation of cluster policy in Ukraine. A prospect for further research can be development of the «intellectual specialization» strategy for regions as an important constituent of the current cluster policy.

  18. Angina pectoris: current therapy and future treatment options.

    Science.gov (United States)

    Parikh, Raj; Kadowitz, Philip J

    2014-02-01

    Angina pectoris is the consequence of an inequality between the demand and supply of blood to the heart. Angina manifests itself as chest pain or discomfort and is a common complaint of patients in the hospital and in the clinic. There are, in fact, roughly half a million new cases of angina per year. Chest pain, while having many etiologies, is generally considered to be most lethal when related to a cardiac cause. In this review, the authors outline the current medical and surgical therapies that are used in the management of angina. Highlights of the various clinical trials that have assisted in the investigation of these therapies are summarized also. Then, the authors provide a focused review of the novel therapy options for angina that are currently being explored. From new medical treatments to revised surgical techniques to the discovery of stem cell therapy, many innovative options are being investigated for the treatment of angina.

  19. Current Treatment Options in Challenging Oral Diseases: Burning Mouth Syndrome

    Directory of Open Access Journals (Sweden)

    Bilgen Erdoğan

    2012-12-01

    Full Text Available Burning mouth syndrome is a chronic condition characterized by burning pain without any signs of an oral mucosal pathology, that usually affects postmenopausal women. Burning sensation is often accompanied by dysgeusia and xerostomia. The pathogenesis of the disease is unknown and an effective treatment option for most of the patients has not been defined yet. The aim of this review is to present current pharmacological and physicological treatments of burning mouth syndrome.

  20. Chapitre 13. Overview of Current Public Policies

    OpenAIRE

    2013-01-01

    Current Public Policies, Rules and Legislation – especially European ones – With Regard to Highly Skilled Immigration, Nationality Regimes, Stay Rights, etc.Binod Khadria Introduction: Three Levels of Public Policies Policies and programs adopted by the developed receiving countries – mainly the United States, Canada, Australia, and the European Union (EU) countries – for the admission of foreign workers with a view to facilitating and/or regulating high-skill immigration fall into three broa...

  1. Monetary Policy and Bond Option Pricing in an Analytical RBC Model

    OpenAIRE

    Söderlind, Paul

    2003-01-01

    This paper analyzes how bond option prices are affected by different types of monetary policy. Analytical results from a general equilibrium model with sticky wages show that employment or output targeting typically give lower bond option prices than inflation targeting.

  2. Current Advanced Power Generation Technologies and Options for China (1)

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ In China,electricity consumption keeps growing at a high speed and installed capacity will be doubled in the next fifteen years.As the world second CO2 producer and also a member of Kyoto Protocol,how to balance energy needs and environmental protection responsibility in the future is a serious problem for China.As such,there are a number of technology choices for today's electric power generation.After discussing the current advanced power generation technologies based on Chinese energy structure and current conditions of power industry,this paper gives a reference to the technology options for China in the future.

  3. Development potentials and policy options of biomass in China.

    Science.gov (United States)

    Shen, Lei; Liu, Litao; Yao, Zhijun; Liu, Gang; Lucas, Mario

    2010-10-01

    Biomass, one of the most important renewable energies, is playing and will continue to play an important role in the future energy structure of the world. This article aims to analyze the position and role, assess the resource availability, discuss the geographic distribution, market scale and industry development, and present the policy options of biomass in China. The resource availability and geographical distribution of biomass byproducts are assessed in terms of crop residues, manure, forest and wood biomass byproducts, municipal waste and wastewater. The position of biomass use for power generation is just next to hydropower among types of renewable energy in China. The potential quantity of all biomass byproducts energy in 2004 is 3511 Mtce (Mtce is the abbreviation of million tons of coal equivalents and 1 Mtce is equal to10(6) tce.), while the acquirable quantity is 460 Mtce. Biomass energy plays a critical role in rural regions of China. The geographical distribution and quantity of biomass byproducts resources depends mainly on the relationship between ecological zones and climate conditions. Our estimation shows that the total quantity of crop residues, manure, forest and wood biomass byproducts, municipal waste and wastewater resources are 728, 3926, 2175, 155 and 48240 Mt (million tons), respectively. Crop residues come mainly from the provinces of Henan, Shandong, Heilongjiang, Jilin and Sichuan. All manure is mainly located in the provinces of Henan, Shandong, Sichuan, Hebei and Hunan. Forest and wood biomass byproducts are mainly produced in the provinces or autonomous regions of Tibet, Sichuan, Yunnan, Heilongjiang and Inner Mongolia, while most of municipal waste mainly comes from Guangdong, Shandong, Heilongjiang, Hubei and Jiangsu. Most of wastewater is largely discharged from advanced provinces like Guangdong, Jiangsu, Zhejiang, Shandong and Henan. Biomass byproducts' energy distribution also varies from province to province in China

  4. Development Potentials and Policy Options of Biomass in China

    Science.gov (United States)

    Shen, Lei; Liu, Litao; Yao, Zhijun; Liu, Gang; Lucas, Mario

    2010-10-01

    Biomass, one of the most important renewable energies, is playing and will continue to play an important role in the future energy structure of the world. This article aims to analyze the position and role, assess the resource availability, discuss the geographic distribution, market scale and industry development, and present the policy options of biomass in China. The resource availability and geographical distribution of biomass byproducts are assessed in terms of crop residues, manure, forest and wood biomass byproducts, municipal waste and wastewater. The position of biomass use for power generation is just next to hydropower among types of renewable energy in China. The potential quantity of all biomass byproducts energy in 2004 is 3511 Mtce (Mtce is the abbreviation of million tons of coal equivalents and 1 Mtce is equal to106 tce.), while the acquirable quantity is 460 Mtce. Biomass energy plays a critical role in rural regions of China. The geographical distribution and quantity of biomass byproducts resources depends mainly on the relationship between ecological zones and climate conditions. Our estimation shows that the total quantity of crop residues, manure, forest and wood biomass byproducts, municipal waste and wastewater resources are 728, 3926, 2175, 155 and 48240 Mt (million tons), respectively. Crop residues come mainly from the provinces of Henan, Shandong, Heilongjiang, Jilin and Sichuan. All manure is mainly located in the provinces of Henan, Shandong, Sichuan, Hebei and Hunan. Forest and wood biomass byproducts are mainly produced in the provinces or autonomous regions of Tibet, Sichuan, Yunnan, Heilongjiang and Inner Mongolia, while most of municipal waste mainly comes from Guangdong, Shandong, Heilongjiang, Hubei and Jiangsu. Most of wastewater is largely discharged from advanced provinces like Guangdong, Jiangsu, Zhejiang, Shandong and Henan. Biomass byproducts’ energy distribution also varies from province to province in China. Based on

  5. The Study on Policy Options for Siting Hazardous Energy Facility

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin Oh [Korea Energy Economics Institute, Euiwang (Korea)

    2000-10-01

    The problem of site allocation on locally unwanted land uses related to energy utilities that extended most recently is becoming a new energy policy issue due to the improvement of national standard of living and livelihood quality. Residents do not generally agree on establishing the construction of public energy utilities in their village due to NIMBY syndrome while they basically agree to have them. These circumstances made a big problem against mass production of industry society and the improvement of the national welfare. Locally unwanted land use related to energy utilities includes waste incineration system, nuclear power plant, coal fired power plant, oil and Gas storage tank, briquette manufacturing plant and etc. Opportunity for SOC projects carried out by central and local government is lost because of the regional egoism. The site dispute between government and residents obstructs optimal energy supply to be necessary for industry growth and the national welfare. The main objective of this study is to propose the policy option for finding a solution after surveying theory and background of site troubles and dispute factors. Final results of this study propose a solution on structural and institutional dispute. The former introduces three kinds of approaches such as tradition, compensation and negotiation. The transition of an environmentally sound energy consumption pattern and the improvement of energy efficiency could be carried out by traditional approaches. To claim the damage and offer the accommodation facilities could be settled by compensational approaches. The establishment of regional decentralization on NIMBY facilities could be settled by negotiatory approaches through fair share criteria. The latter proposes 1) 'polluter pays principle', 2) internalization of social cost and benefit on air or water pollution, 3) the behind - the - scene negotiation in a bid to settle a site dispute, 4) and supporting system for peripheral areas

  6. Current and emerging treatment options for myopic choroidal neovascularization

    Directory of Open Access Journals (Sweden)

    El Matri L

    2015-04-01

    Full Text Available Leila El Matri, Ahmed Chebil, Fedra Kort Department B of Ophthalmology, Hedi Rais Institute of Ophthalmology, Faculty of Medicine of Tunis, University of El Manar, Tunis, Tunisia Abstract: Choroidal neovascularization (CNV is the main cause of visual impairment in highly myopic patients younger than 50 years of age. There are different treatments for myopic CNV (mCNV, with 5- to 10-year outcomes currently. Chorioretinal atrophy is still the most important determinant factor for visual outcome. The purpose of this study is to provide an overview of the current treatments for mCNV, including laser, surgical management, verteporfin photodynamic therapy, and mainly anti-vascular endothelial growth factor therapy. Emerging treatment options are also discussed. Keywords: myopia, choroidal neovascularization, current treatment, emerging treatment

  7. Fertility preservation in children and adolescents: current options and considerations.

    Science.gov (United States)

    McCracken, Kate; Nahata, Leena

    2017-10-01

    The purpose of this review is to outline current pediatric fertility preservation options, and discuss ethical and financial considerations impacting this rapidly expanding field. With the improvement in treatment of pediatric malignancies and medical conditions that threaten fertility, survival rates are increasing. Therefore, minimizing long-term morbidities such as gonadal damage and infertility is of utmost importance. Impaired fertility not only has a significant negative impact on patient's quality of life; in women, gonadal damage puts patients at risk for premature menopause, and increased risk of cardiac, skeletal, and cognitive issues. Fortunately, fertility preservation options exist for both female and male prepubertal and pubertal patients, and discussion of such options with patients and their families prior to the initiation of therapy and/or before further deterioration of gonadal function is crucial. A multidisciplinary approach to fertility counseling, with attention to the patient's goals and cultural beliefs, is ideal. Although several national organizations support integrating a fertility consultation into routine care, fertility preservation is still underutilized. Continued research is needed to understand barriers for patients/families and reduce the number of missed opportunities for fertility preservation.

  8. Current Advanced Power Generation Technologies and Options for China (2)

    Institute of Scientific and Technical Information of China (English)

    Deng Nubo; Mohsen Assadi; Yang Cheng

    2008-01-01

    @@ In China,electricity consumption keeps growing at a high speed and installed capacity will be doubled in the next fifteen years.As the world second CO2 producer and also a member of Kyoto Protocol,how to balance energy needs arid environmental protection responsibility in the future is a serious problem for China.As such,there are a number of technology choices for today's electric power generation.After discussing the current advanced power generation technologies based on Chinese energy structure and current conditions of power industry,this paper gives a reference to the technology options for China in the future.Here published is the second part of the paper.

  9. Age-related macular degeneration: current treatment and future options.

    Science.gov (United States)

    Moutray, Tanya; Chakravarthy, Usha

    2011-09-01

    Age-related macular degeneration is the leading cause of visual impairment among older adults in the developed world. Epidemiological studies have revealed a number of genetic, ocular and environmental risk factors for this condition, which can be addressed by disease reduction strategies. We discuss the various treatment options for dry and exudative age-related macular degeneration available and explain how the recommended treatment depends on the exact type, location and extent of the degeneration. Currently, vascular endothelial growth factor (VEGF) inhibition therapy is the best available treatment for exudative age-related macular degeneration but is limited by the need for repeated intravitreal injections. The current treatment regime is being refined through research on optimal treatment frequency and duration and type of anti-VEGF drug. Different modes of drug delivery are being developed and in the future other methods of VEGF inhibition may be used.

  10. The nuclear power option in the Italian energy policy

    Energy Technology Data Exchange (ETDEWEB)

    Di Nucci, M.R.

    2006-07-15

    Italy took a pioneering role in the early development of nuclear power. This source of energy should have provided the answer to the lack of domestic fossil resources. Due to the cheap oil prices, the influence of the state hydrocarbons company ENI and an influential petroleum lobby, following the nationalisation of the electricity sector in the early sixties, the nuclear option was no longer consequently pursued. Italy became heavily dependent on imported oil. Although in the period 1974-1975 an intensive nuclear power development programme was launched, the share of nuclear power remained marginal. In the aftermath of the Chernobyl disaster and following the referendum phasing out nuclear power in 1987, the national energy policy was newly defined. Our analysis will follow the customary practice to subdivide the Italian nuclear power development into three phases: the pioneering years till the mid-1960s; the period between 1966 and 1987 and the post-Chernobyl phase. We discuss the early phase at a certain length, since it is symptomatic of the way in Italy technological and industrial matters are dealt with and well illustrates the alliance games and behaviour of still existing market players. Although disputes about the alleged advantages of nuclear power are revived with certain regularity and are justified with arguments such as climate change and dependence on imported fuel, we argue that a return to nuclear power in Italy is not foreseeable. Nonetheless, the country cannot be considered a nuclear-free area. Nuclear wastes still play a disquieting role and imported electricity is generated also by nuclear power. Moreover, another tendency has set through. Due to a large liquidity provided by the mandated divestments in the framework of the liberalisation of the electricity market, the previous monopolist ENEL is heavily investing in generating capacities, including stakes in nuclear plants abroad, especially in new EU countries. (author)

  11. Current status in the treatment options for esophageal achalasia.

    Science.gov (United States)

    Chuah, Seng-Kee; Chiu, Chien-Hua; Tai, Wei-Chen; Lee, Jyong-Hong; Lu, Hung-I; Changchien, Chi-Sin; Tseng, Ping-Huei; Wu, Keng-Liang

    2013-09-07

    Recent advances in the treatment of achalasia include the use of high-resolution manometry to predict the outcome of patients and the introduction of peroral endoscopic myotomy (POEM). The first multicenter randomized, controlled, 2-year follow-up study conducted by the European Achalasia Trial group indicated that laparoscopic Heller myotomy (LHM) was not superior to pneumatic dilations (PD). Publications on the long-term success of laparoscopic surgery continue to emerge. In addition, laparoscopic single-site surgery is applicable to advanced laparoscopic operations such as LHM and anterior fundoplication. The optimal treatment option is an ongoing matter of debate. In this review, we provide an update of the current progress in the treatment of esophageal achalasia. Unless new conclusive data prove otherwise, LHM is considered the most durable treatment for achalasia at the expense of increased reflux-associated complications. However, PD is the first choice for non-surgical treatment and is more cost-effective. Repeated PD according to an "on-demand" strategy based on symptom recurrence can achieve long-term remission. Decision making should be based on clinical evidence that identifies a subcategory of patients who would benefit from specific treatment options. POEM has shown promise but its long-term efficacy and safety need to be assessed further.

  12. Viral myocarditis--diagnosis, treatment options, and current controversies.

    Science.gov (United States)

    Pollack, Ari; Kontorovich, Amy R; Fuster, Valentin; Dec, G William

    2015-11-01

    Myocarditis--a frequent cause of dilated cardiomyopathy and sudden cardiac death--typically results from cardiotropic viral infection followed by active inflammatory destruction of the myocardium. Characterization of this disease has been hampered by its heterogeneous clinical presentations and diverse aetiologies. Advances in cardiac MRI and molecular detection of viruses by endomyocardial biopsy have improved our ability to diagnose and understand the pathophysiological mechanisms of this elusive disease. However, therapeutic options are currently limited for both the acute and chronic phases of myocarditis. Several randomized, controlled trials have demonstrated potential benefit with immunosuppressive and immunomodulatory therapies, but further investigations are warranted. In this Review, we explore the pathophysiology, natural history, and modes of diagnosis of myocarditis, as well as evidence-based treatment strategies. As novel imaging techniques and human in vitro models of the disease emerge, the landscape of therapies for myocarditis is poised to improve.

  13. Current treatment options for colon cancer peritoneal carcinomatosis.

    Science.gov (United States)

    Aoyagi, Tomoyoshi; Terracina, Krista P; Raza, Ali; Takabe, Kazuaki

    2014-09-21

    Peritoneal carcinomatosis (PC), the dissemination of cancer cells throughout the lining of the abdominal cavity, is the second most common presentation of colon cancer distant metastasis. Despite remarkable advances in cytotoxic chemotherapy and targeted therapy for colon cancer over the last 15 years, it has been repeatedly shown that these therapies remain ineffective for colon cancer PC. Recently, there has been a rapid accumulation of reports that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) prolongs the life of colon cancer PC patients. Here, we will review the clinical presentation, the mechanisms of disease progression, and current treatment options for colon cancer PC, with a focus on the benefits and limitations of CRS-HIPEC.

  14. Ragweed-induced allergic rhinoconjunctivitis: current and emerging treatment options

    Directory of Open Access Journals (Sweden)

    Ihler F

    2015-02-01

    Full Text Available Friedrich Ihler, Martin CanisDepartment of Otorhinolaryngology, University Medical Center Göttingen, Göttingen, GermanyAbstract: Ragweed (Ambrosia spp. is an annually flowering plant whose pollen bears high allergenic potential. Ragweed-induced allergic rhinoconjunctivitis has long been seen as a major immunologic condition in Northern America with high exposure and sensitization rates in the general population. The invasive occurrence of ragweed (A. artemisiifolia poses an increasing challenge to public health in Europe and Asia as well. Possible explanations for its worldwide spread are climate change and urbanization, as well as pollen transport over long distances by globalized traffic and winds. Due to the increasing disease burden worldwide, and to the lack of a current and comprehensive overview, this study aims to review the current and emerging treatment options for ragweed-induced rhinoconjunctivitis. Sound clinical evidence is present for the symptomatic treatment of ragweed-induced allergic rhinoconjunctivitis with oral third-generation H1-antihistamines and leukotriene antagonists. The topical application of glucocorticoids has also been efficient in randomized controlled clinical trials. Combined approaches employing multiple agents are common. The mainstay of causal treatment to date, especially in Northern America, is subcutaneous immunotherapy with the focus on the major allergen, Amb a 1. Beyond this, growing evidence from several geographical regions documents the benefit of sublingual immunotherapy. Future treatment options promise more specific symptomatic treatment and fewer side effects during causal therapy. Novel antihistamines for symptomatic treatment are aimed at the histamine H3-receptor. New adjuvants with toll-like receptor 4 activity or the application of the monoclonal anti-immunoglobulin E antibody, omalizumab, are supposed to enhance conventional immunotherapy. An approach targeting toll-like receptor 9 by

  15. Bringing biofuels on the market. Options to increase EU biofuels volumes beyond the current blending limits

    Energy Technology Data Exchange (ETDEWEB)

    Kampman, B.; Van Grinsven, A.; Croezen, H. [CE Delft, Delft (Netherlands); Verbeek, R.; Van Mensch, P.; Patuleia, A. [TNO, Delft, (Netherlands)

    2013-07-15

    This handbook on biofuels provides a comprehensive overview of different types of biofuels, and the technical options that exist to market the biofuels volumes expected to be consumed in the EU Member States in 2020. The study concludes that by fully utilizing the current blending limits of biodiesel (FAME) in diesel (B7) and bioethanol in petrol (E10) up to 7.9% share of biofuels in the EU transport sector can be technically reached by 2020. Increasing use of advanced biofuels, particularly blending of fungible fuels into diesel (eg. HVO and BTL) and the use of higher ethanol blends in compatible vehicles (e.g. E20), can play an important role. Also, the increased use of biomethane (in particular bio-CNG) and higher blends of biodiesel (FAME) can contribute. However, it is essential for both governments and industry to decide within 1 or 2 years on the way ahead and take necessary actions covering both, the fuels and the vehicles, to ensure their effective and timely implementation. Even though a range of technical options exist, many of these require considerable time and effort to implement and reach their potential. Large scale implementation of the options beyond current blending limits requires new, targeted policy measures, in many cases complemented by new fuel and vehicle standards, adaptation of engines and fuel distribution, etc. Marketing policies for these vehicles, fuels and blends are also likely to become much more important than in the current situation. Each Member State may develop its own strategy tailored to its market and policy objectives, but the EU should play a crucial facilitating role in these developments.

  16. Current and emerging treatment options for nasopharyngeal carcinoma

    Directory of Open Access Journals (Sweden)

    Spratt DE

    2012-10-01

    Full Text Available Daniel E Spratt, Nancy LeeDepartment of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: In this article, we focus on the current and emerging treatments in nasopharyngeal cancer (NPC. A detailed evolution of the current standard of care, and new techniques and treatment options will be reviewed. Intergroup 0099 established the role for chemoradiotherapy (chemo-RT in the treatment of nasopharyngeal carcinoma. Multiple randomized Phase III trials have shown the benefit of chemo-RT; however, none of these studies utilized modern radiotherapy (RT techniques of intensity-modulated radiation therapy (IMRT. IMRT has the ability to deliver high doses of radiation to the target structures while sparing adjacent bystander healthy tissues, and has now become the preferred RT treatment modality. Chemotherapy also has had a shifting paradigm of induction and/or adjuvant chemotherapy combined with RT alone, to the investigation with concurrent chemo-RT. New treatment options including targeted monoclonal antibodies and small molecule tyrosine kinase inhibitors are being studied in NPC. These new biologic therapies have promising in vitro activity for NPC, and emerging clinical studies are beginning to define their role. RT continues to expand its capabilities, and since IMRT and particle therapy, specifically intensity-modulated proton therapy (IMPT, has reports of impressive dosimetric efficacy in-silica. Adaptive RT is attempting to reduce toxicity while maintaining treatment efficacy, and the clinical results are still in their youth. Lastly, Epstein–Barr virus (EBV DNA has recently been studied for prediction of tumor response and its use as a biomarker is increasingly promising to aid in early detection as well as supplementing the current staging system. RT with or without chemotherapy remains the standard of care for nasopharyngeal carcinoma. Advances in RT technique, timing of chemotherapy, biologically

  17. Teaching Policy Analysis as Research: Consideration and Extension of Options

    Science.gov (United States)

    O'Connor, Mary Katherine; Netting, F. Ellen

    2008-01-01

    Teaching policy analysis is compared to teaching research skills. Both involve the selection of an appropriate analytical tool to be used with multiple units of analysis; and in both, the selected instrument must fit the purpose of the analysis or the product is not useful. Policy analysis frameworks characteristically address policy process,…

  18. Management of keloids and hypertrophic scars: current and emerging options

    Directory of Open Access Journals (Sweden)

    Gauglitz GG

    2013-04-01

    Full Text Available Gerd G GauglitzDepartment of Dermatology and Allergy, Ludwig-Maximilian University, Munich, GermanyAbstract: In the context of growing aesthetic awareness, a rising number of patients feel disappointed with their scars and are frequently seeking help for functional and aesthetic improvement. However, excessive scarring following surgery or trauma remains difficult to improve despite a plethora of advocated treatment strategies as frequently observed in daily clinical routine. It is thus still preferable to prevent scarring by minimizing risk factors as much as possible. Hence, it remains crucial for the physician to be aware of basic knowledge of healing mechanisms and skin anatomy, as well as an appreciation of suture material and wound closure techniques to minimize the risk of postoperative scarring. Next to existing, well known prophylactic and therapeutic strategies for the improvement of excessive scarring, this article discusses emerging techniques such as intralesional cryotherapy, intralesional 5-fluorouracil, interferon, and bleomycin. Some of them have been successfully tested in well-designed trials and already have extended or may extend the current spectrum of excessive scar treatment in the near future. Innovative options such as imiquimod 5% cream, photodynamic therapy, or botulinum toxin A may also be of certain importance; however, the data currently available is too contradictory for definite recommendations.Keywords: intralesional cryotherapy, lasers, triamcinolone acetonide, TGF-β

  19. Current and emerging treatment options for uveal melanoma

    Directory of Open Access Journals (Sweden)

    Pereira PR

    2013-08-01

    Full Text Available Patricia Rusa Pereira,1 Alexandre Nakao Odashiro,2 Li-Anne Lim,1 Cristina Miyamoto,1 Paula L Blanco,4 Macanori Odashiro,3 Shawn Maloney,1 Dominique F De Souza,1 Miguel N Burnier Jr1 1The Henry C Witelson Ocular Pathology Laboratory, McGill University, Montreal, QC, Canada; 2Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; 3Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil; 4Department of Pathology and Laboratory Medicine, University of Ottawa, ON, Canada Abstract: Uveal melanoma (UM is the most common primary malignant intraocular tumor in adults, with a 10-year cumulative metastatic rate of 34%. The most common site of metastasis is the liver (95%. Unfortunately, the current treatment of metastatic UM is limited by the lack of effective systemic therapy. Options for the management of the primary intraocular tumor include radical surgery as well as conservative treatments in order to preserve visual acuity. For metastatic disease, several approaches have been described with no standard method. Nevertheless, median survival after liver metastasis is poor, being around 4–6 months, with a 1-year survival of 10%–15%. In this review, the authors summarize current and promising new treatments for UM. Keywords: uveal melanoma, choroidal melanoma, eye, metastasis, treatment, therapy

  20. Respiratory syncytial virus: current and emerging treatment options

    Directory of Open Access Journals (Sweden)

    Turner TL

    2014-04-01

    Full Text Available Tiffany L Turner,1 Benjamin T Kopp,1 Grace Paul,1 Lindsay C Landgrave,2 Don Hayes Jr,1 Rohan Thompson11Department of Pediatrics, Ohio State University College of Medicine, 2Clinical Pharmacy, Nationwide Children's Hospital, Columbus, OH, USAAbstract: Respiratory syncytial virus (RSV is an important respiratory pathogen in infants and children worldwide. Although RSV typically causes mild upper respiratory infections, it frequently causes severe morbidity and mortality, especially in premature infants and children with other chronic diseases. Treatment of RSV is limited by a lack of effective antiviral treatments; however, ribavirin has been used in complicated cases, along with the addition of intravenous immune globulin in specific patients. Vaccination strategies for RSV prevention are heavily studied, but only palivizumab (Synagis® has been approved for use in the United States in very select patient populations. Research is ongoing in developing additional vaccines, along with alternative therapies that may help prevent or decrease the severity of RSV infections in infants and children. To date, we have not seen a decrement in RSV morbidity and mortality with our current options; therefore, there is a clear need for novel RSV preventative and therapeutic strategies. In this review, we discuss the current and evolving trends in RSV treatment for infants and children.Keywords: bronchiolitis, lower respiratory tract infection, respiratory syncytial virus, probiotics, vitamin D

  1. Table of Policy Options for Smart Growth Fixes for Climate Adaptation and Resilience

    Science.gov (United States)

    Sortable table of policy options discussed in the publication Smart Growth Fixes for Climate Adaptation and Resilience, which can help local governments prepare for climate change while gaining other environmental, economic, health, and social benefits

  2. Book Review: Regulating Private Tutoring for Public Good: Policy Options for Supplementary Education in Asia

    Directory of Open Access Journals (Sweden)

    T. Marimuthu

    2015-10-01

    Full Text Available Book Review Regulating Private Tutoring for Public Good: Policy Options for Supplementary Education in Asia By Mark Bray and Ora Kwo (2014, 93pp. ISBN: 978-988-17852-9-9, Hong Kong: Comparative Education Research Centre.

  3. Current and emerging treatment options for Peyronie's disease

    Directory of Open Access Journals (Sweden)

    Gokce A

    2013-01-01

    Full Text Available Ahmet Gokce, Julie C Wang, Mary K Powers, Wayne JG HellstromDepartment of Urology, Tulane University – School of Medicine, New Orleans, LA, USAAbstract: Peyronie's disease (PD is a condition of the penis, characterized by the presence of localized fibrotic plaque in the tunica albuginea. PD is not an uncommon disorder, with recent epidemiologic studies documenting a prevalence of 3–9% of adult men affected. The actual prevalence of PD may be even higher. It is often associated with penile pain, anatomical deformities in the erect penis, and difficulty with intromission. As the definitive pathophysiology of PD has not been completely elucidated, further basic research is required to make progress in the understanding of this enigmatic condition. Similarly, research on effective therapies is limited. Currently, nonsurgical treatments are used for those men who are in the acute stage of PD, whereas surgical options are reserved for men with established PD who cannot successfully penetrate. Intralesional treatments are growing in clinical popularity as a minimally invasive approach in the initial treatment of PD. A surgical approach should be considered when men with PD do not respond to conservative, medical, or minimally invasive therapies for approximately 1 year and cannot have satisfactory sexual intercourse. As scientific breakthroughs in the understanding of the mechanisms of this disease process evolve, novel treatments for the many men suffering with PD are anticipated.Keywords: oral therapy, intralesional treatment, topical therapy, extracorporeal shockwave therapy, traction devices, plication, incision and grafting, penile prosthesis.

  4. Current and emerging treatment options for Graves’ hyperthyroidism

    Directory of Open Access Journals (Sweden)

    Prakash Abraham

    2009-12-01

    Full Text Available Prakash Abraham1, Shamasunder Acharya21Department of Endocrinology, Aberdeen Royal Infirmary, Aberdeen, UK; 2Department of Endocrinology, John Hunter Hospital, New Lambton NSW, AustraliaAbstract: Radioiodine, antithyroid drugs and surgery have been well established therapies for Graves’ hyperthyroidism for several decades. However there remain large variations in practice among physicians in the preferred modality and the method of administration. Patient choice and perceptions also play a big role in the choice of treatment. Radioiodine may be given using fixed high doses or by calculated doses following uptake studies. The risks of radioiodine including eye disease and the role of prophylactic steroid therapy are discussed. The commonly used antithyroid drugs include carbimazole, methimazole and propylthiouracil; however a number of other agents have been tried in special situations or in combination with these drugs. The antithyroid drugs may be given in high (using additional levothyroxine in a block–replace regimen or low doses (in a titration regimen. This review examines the current evidence and relative benefits for these options as well as looking at emerging therapies including immunomodulatory treatments such as rituximab which have come into early clinical trials. The use of antithyroid therapies in special situations is also discussed as well as clinical practice issues which may influence the choices.Keywords: Graves’ hyperthyroidism, radioiodine, antithyroid drugs, methimazole, propylthiouracil

  5. Sarcoidosis: an update on current pharmacotherapy options and future directions.

    Science.gov (United States)

    Brito-Zerón, Pilar; Pérez-Alvarez, Roberto; Pallarés, Lucio; Retamozo, Soledad; Baughman, Robert P; Ramos-Casals, Manuel

    2016-12-01

    Sarcoidosis is a systemic disease of unknown etiology characterized by the development of non-caseating epitheloid granulomas. The lungs are the most commonly involved organ (>90% of cases), followed by the lymph nodes, the skin, and the eyes. Areas covered: This review summarizes current pharmacotherapy options and future directions for the development of new therapies. Glucocorticoids are the first-line therapy for sarcoidosis. For patients with the most severe forms of sarcoidosis (who will need glucocorticoids for long periods) and for those intolerant or refractory, immunosuppressive drugs are used as sparing agents. The management of extrathoracic sarcoidosis must be tailored to the specific organ or organs involved; however, there is limited data from controlled trials to guide the treatment of these patients. The emergence of biological therapies has increased the therapeutic armamentarium available to treat sarcoidosis, with monoclonal anti-TNF agents being the most promising, but their use is still limited by a lack of licensing and costs. Expert commentary: The treatment of sarcoidosis is still not totally standardized. New effective therapies are urgently needed to enable the reduction or replacement of long-term therapy with glucocorticoids in patients with sarcoidosis.

  6. Diagnosis of Helicobacter pylori infection: Current options and developments

    Science.gov (United States)

    Wang, Yao-Kuang; Kuo, Fu-Chen; Liu, Chung-Jung; Wu, Meng-Chieh; Shih, Hsiang-Yao; Wang, Sophie SW; Wu, Jeng-Yih; Kuo, Chao-Hung; Huang, Yao-Kang; Wu, Deng-Chyang

    2015-01-01

    Accurate diagnosis of Helicobacter pylori (H. pylori) infection is a crucial part in the effective management of many gastroduodenal diseases. Several invasive and non-invasive diagnostic tests are available for the detection of H. pylori and each test has its usefulness and limitations in different clinical situations. Although none can be considered as a single gold standard in clinical practice, several techniques have been developed to give the more reliable results. Invasive tests are performed via endoscopic biopsy specimens and these tests include histology, culture, rapid urease test as well as molecular methods. Developments of endoscopic equipment also contribute to the real-time diagnosis of H. pylori during endoscopy. Urea breathing test and stool antigen test are most widely used non-invasive tests, whereas serology is useful in screening and epidemiological studies. Molecular methods have been used in variable specimens other than gastric mucosa. More than detection of H. pylori infection, several tests are introduced into the evaluation of virulence factors and antibiotic sensitivity of H. pylori, as well as screening precancerous lesions and gastric cancer. The aim of this article is to review the current options and novel developments of diagnostic tests and their applications in different clinical conditions or for specific purposes. PMID:26523098

  7. Diagnosis of Helicobacter pylori infection: Current options and developments.

    Science.gov (United States)

    Wang, Yao-Kuang; Kuo, Fu-Chen; Liu, Chung-Jung; Wu, Meng-Chieh; Shih, Hsiang-Yao; Wang, Sophie S W; Wu, Jeng-Yih; Kuo, Chao-Hung; Huang, Yao-Kang; Wu, Deng-Chyang

    2015-10-28

    Accurate diagnosis of Helicobacter pylori (H. pylori) infection is a crucial part in the effective management of many gastroduodenal diseases. Several invasive and non-invasive diagnostic tests are available for the detection of H. pylori and each test has its usefulness and limitations in different clinical situations. Although none can be considered as a single gold standard in clinical practice, several techniques have been developed to give the more reliable results. Invasive tests are performed via endoscopic biopsy specimens and these tests include histology, culture, rapid urease test as well as molecular methods. Developments of endoscopic equipment also contribute to the real-time diagnosis of H. pylori during endoscopy. Urea breathing test and stool antigen test are most widely used non-invasive tests, whereas serology is useful in screening and epidemiological studies. Molecular methods have been used in variable specimens other than gastric mucosa. More than detection of H. pylori infection, several tests are introduced into the evaluation of virulence factors and antibiotic sensitivity of H. pylori, as well as screening precancerous lesions and gastric cancer. The aim of this article is to review the current options and novel developments of diagnostic tests and their applications in different clinical conditions or for specific purposes.

  8. Current options in local anesthesia for groin hernia repairs.

    Science.gov (United States)

    Kulacoglu, Hakan; Alptekin, Alp

    2011-01-01

    Inguinal hernia repair is one of the most common procedures in general surgery. All anesthetic methods can be used in inguinal hernia repairs. Local anesthesia for groin hernia repair had been introduced at the very beginning of the last century, and gained popularity following the success reports from the Shouldice Hospital, and the Lichtenstein Hernia Institute. Today, local anesthesia is routinely used in specialized hernia clinics, whereas its use is still not a common practice in general hospitals, in spite of its proven advantages and recommendations by current hernia repair guidelines. In this review, the technical options for local anaesthesia in groin hernia repairs, commonly used local anaesthetics and their doses, potential complications related to the technique are evaluated. A comparison of local, general and regional anesthesia methods is also presented. Local anaesthesia technique has a short learning curve requiring simple training. It is easy to learn and apply, and its use is in open anterior repairs a nice way for health care economics. Local anesthesia has been shown to have certain advantages over general and regional anesthesia in inguinal hernia repairs. It is more economic and requires a shorter time in the operating room and shorter stay in the institution. It causes less postoperative pain, requires less analgesic consumption; avoids nausea, vomiting, and urinary retention. Patients can mobilize and take oral liquids and solid foods much earlier. Most importantly, local anesthesia is the most suitable type of anesthesia in elder, fragile patients and patients with ASA II-IV scores.

  9. U.S. weapons-usable plutonium disposition policy: Implementation of the MOX fuel option

    Energy Technology Data Exchange (ETDEWEB)

    Woods, A.L. [ed.] [Amarillo National Resource Center for Plutonium, TX (United States); Gonzalez, V.L. [Texas A and M Univ., College Station, TX (United States). Dept. of Political Science

    1998-10-01

    A comprehensive case study was conducted on the policy problem of disposing of US weapons-grade plutonium, which has been declared surplus to strategic defense needs. Specifically, implementation of the mixed-oxide fuel disposition option was examined in the context of national and international nonproliferation policy, and in contrast to US plutonium policy. The study reveals numerous difficulties in achieving effective implementation of the mixed-oxide fuel option including unresolved licensing and regulatory issues, technological uncertainties, public opposition, potentially conflicting federal policies, and the need for international assurances of reciprocal plutonium disposition activities. It is believed that these difficulties can be resolved in time so that the implementation of the mixed-oxide fuel option can eventually be effective in accomplishing its policy objective.

  10. Modelling Options for Policy Impact Analysis on African Dairy Farms

    Directory of Open Access Journals (Sweden)

    Oghaiki Asaah NDAMBI

    2008-01-01

    Full Text Available Studies on the priorities for agricultural research in Eastern and CentralAfrica concluded that milk is the most important commodity for research anddevelopment in the region, based on its potential contribution to the agriculturalGDP. It has been presumed that, the right policies, marketing systems and technicalsupport must be sought for dairy development in Africa. In order to determine theright development pattern, appropriate analytical tools must be applied. The TIPICAL(Technology Impact Policy Impact model was used to analyse the impact ofdifferent policies on two typical dairy farming systems in Uganda, which accountfor more than 70% of milk produced in the country. Seven influential policy areaswere also identified: provision of veterinary services, consumption promotion,marketing promotion, input provision, credit access improvement, milk qualityimprovement and genetic improvement. In general, the policy impacts are very littleon farms with local cows but can be magnified up to threefold, if the farms havegraded cows. Policies which improve farmers’ accessibility to markets have thegreatest impacts. The results obtained from this model were compared to thoseusing the EXTRAPOLATE model. This comparison shows that both models couldcomplement each other in analysing policy impacts on African dairy farms.However, differences in results from the models indicate that more focus should bemade on farmers’ willingness to adopt new technology.

  11. Policy Options for the Improvement of the European Patent System

    DEFF Research Database (Denmark)

    Schovsbo, Jens Hemmingsen; Cowin, Robin; Van de Eijck, Wim

    2007-01-01

    for the improvement of the European patent system are presented and discussed fully at the end of the report. Below is a simple list of the titles of the options: Insertion of the economic mission of the patent system in the European Patent Convention; Enhancing governance within the European patent system; Improving...

  12. Payout phase in DC pension funds – policy option - Theoretical considerations and Albanian available options

    Directory of Open Access Journals (Sweden)

    Enkeleda Shehi

    2015-11-01

    Full Text Available The aim of this paper is to provide a brief overview of the third pillar of pensions in Albania and what are the different alternatives related to the payout. Referring to the actual development of this market in Albania, experience of the actors involved, I find it indispensable and necessary to provide some theoretical background and considerations, and then build up a simple model of projection of a pension scheme cost and a model for payout alternatives for the Albanian pension funds. A great deal of importance is shown towards posing the assumptions. Also, the paper gives an explanation about the differences among different payout options and suggests the best option for the existing pension funds in Albania. The best option represents my conclusion and recommendation for the actual third pillar of pensions and the others that might join latter. To sum up, the first conclusion of the paper is that the annuity option is the best alternative for the payout phase of the pensions. It has the advantage of providing the highest protection against the risk of longevity. The second conclusion is that based on other countries experiences, the annuity market have to be developed hand in hand with the pension system development. Therefore Albania should rely on and follow this experience.

  13. Agricultural GHG emissions in the EU: an exploratory economic assessment of mitigation policy options

    NARCIS (Netherlands)

    Perez Dominguez, I.; Fellmann, T.; Witzke, H.P.; Jansson, T.; Oudendag, D.; Gocht, A.; Verhoog, A.D.

    2012-01-01

    This report provides a quantitative assessment of possible implications of the implementation of specific policy options to mitigate agricultural greenhouse gas (GHG) emissions in the EU. The mitigation policy scenarios proposed and analysed within this report are all exploratory, i.e. it is intende

  14. Veterans’ Disability Compensation: Trends and Policy Options

    Science.gov (United States)

    2014-08-01

    veterans to claim benefits, the recent conflicts in Iraq and Afghanistan, and difficult labor market conditions during the past several years. Spending...Than the Full Retirement Age for Social Security All veterans 17 Phased in for veterans age 65 or younger in 2015 8 Option 5: Supplement Payments to...available to service members who do not qualify for a DoD-approved medi - cal separation. The difference between the two programs is in the time frame

  15. INTEGRATION POLICY TOWARDS IMMIGRANTS: CURRENT EXPERIENCE

    Directory of Open Access Journals (Sweden)

    Nadiia Bureiko

    2012-03-01

    Full Text Available In the contemporary world the intensity of the immigration movements is constantly increasing. Countries which experience great immigrant flows are facing numerous problems which should be solved. The article studies the current immigration flows in EU countries, the United States of America and Canada and presents three main models of integration policy towards immigrants – political assimilation, functional integration and multicultural model. Separate models are distinguished for the Muslims’ integration. The author examines the peculiarities of every model and examines the conclusions provided by the Migrant Integration Policy Index (MIPEX concerning the situation of the immigrants’ integration in 31 countries in 2011. Among all the policy indicators the first that are defined are as follows: political participation, education, labour market mobility and anti-discrimination. The situation with immigrants’ integration in Ukraine is also studied as it is gaining a great attention of the authorities and the public. The measures and practical steps done regarding this situation in Ukraine in recent years are analyzed using the information offered by the State Migration Service of Ukraine.

  16. Clean Energy Policy Analysis: Impact Analysis of Potential Clean Energy Policy Options for the Hawaii Clean Energy Initiative (HCEI)

    Energy Technology Data Exchange (ETDEWEB)

    Busche, S.; Doris, E.; Braccio, R.; Lippert, D.; Finch, P.; O' Toole, D.; Fetter, J.

    2010-04-01

    This report provides detailed analyses of 21 clean energy policy options considered by the Hawaii Clean Energy Initiative working groups for recommendation to the 2010 Hawaii State Legislature. The report considers the impact each policy may have on ratepayers, businesses, and the state in terms of energy saved, clean energy generated, and the financial costs and benefits. The analyses provide insight into the possible impacts, both qualitative and quantitative, that these policies may have in Hawaii based on the experience with these policies elsewhere. As much as possible, the analyses incorporate Hawaii-specific context to reflect the many unique aspects of energy use in the State of Hawaii.

  17. Policy options for the improvement of the European patent system

    DEFF Research Database (Denmark)

    Elsmore, Matthew J.

    2008-01-01

    and within certain sectors such that various improvements can be made. Thus, the aim of this report is: to analyze the historical and present impact of the European patent system on innovation and diffusion of knowledge to identify current key trends in the patent system to identify the challenges...... and their distribution. Finding the right balance is important, since the reward offered to inventors in the form of exclusive rights provides the incentive to innovate, but if the reward is too excessive, it may hamper innovation and the distribution of knowledge. The general premise of this report is that the European...... on two occasions. The study was requested by STOA, a body whose brief is the 'Assessment of Scientific and Technological Policy Options for the European Parliament'....

  18. United States Policy Options in the Western Indian Ocean.

    Science.gov (United States)

    1982-06-01

    of the world. 31 The typical economic structure of one of these countries con- sists of a large agricultural sector comprising most of the labour ...lation policy and there are no programs designed to aid family planning. These programs must be undertaken soon or the prob- lems of overpopulation

  19. An Empirical Exploration of Selected Policy Options in Organ Donation.

    Science.gov (United States)

    Klenow, Daniel J.; Youngs, George A., Jr.

    1995-01-01

    Presents findings from a mail survey of 414 persons regarding organ transplantation and donation policy issues. Gauged three measures of support for organ donation: donor card commitment, required request of next-of-kin support, and weak presumed consent support. High levels of support exist for organ donor cards and the next-of-kin law. Little…

  20. Cost benefit analysis of two policy options for cannabis: status quo and legalisation.

    Science.gov (United States)

    Shanahan, Marian; Ritter, Alison

    2014-01-01

    To date there has been limited analysis of the economic costs and benefits associated with cannabis legalisation. This study redresses this gap. A cost benefit analysis of two cannabis policy options the status quo (where cannabis use is illegal) and a legalised-regulated option was conducted. A cost benefit analysis was used to value the costs and benefits of the two policies in monetary terms. Costs and benefits of each policy option were classified into five categories (direct intervention costs, costs or cost savings to other agencies, benefits or lost benefits to the individual or the family, other impacts on third parties, and adverse or spill over events). The results are expressed as a net social benefit (NSB). The mean NSB per annum from Monte Carlo simulations (with the 5 and 95 percentiles) for the status quo was $294.6 million AUD ($201.1 to $392.7 million) not substantially different from the $234.2 million AUD ($136.4 to $331.1 million) for the legalised-regulated model which excludes government revenue as a benefit. When government revenue is included, the NSB for legalised-regulated is higher than for status quo. Sensitivity analyses demonstrate the significant impact of educational attainment and wellbeing as drivers for the NSB result. Examining the percentiles around the two policy options, there appears to be no difference between the NSB for these two policy options. Economic analyses are essential for good public policy, providing information about the extent to which one policy is substantially economically favourable over another. In cannabis policy, for these two options this does not appear to be the case.

  1. The economic policy options and their connection with inflation and unemployment

    Directory of Open Access Journals (Sweden)

    Bogna Kopeć

    2015-04-01

    Full Text Available Economic system after 1990 had many fluctuations. This article applies to two essential phenomena in a free market economy: inflation and unemployment. This article applies to changes in the process of inflation and fluctuations in the unemployment rate under different economic policy options. Economic policies can affect the development of the inflation and unemployment. It includes interest rates and budget deficits. Methodology of model is based on a pendulum. Economic policy has been designated as a synthetic indicator of the resultant two policies - monetary and fiscal policies. With the help of the pendulum model has been established that the character had run monetary and fiscal policy, and how developed as economic policy. By the dominance of one of the policy options is understood that during cycles level inflation or the deficit fluctuated strongly to economic stabilization. One of the stages of the study was to analyze the monetary policy and assess whether there is a link between the evolution of interest rates and the evolution of the inflation rate. In a similar way, fiscal policy was analyzed. This article attempts to determine whether the conduct of economic policy was correct, and has had an impact on the economic situation.

  2. Accounting Policy Options under IFRS: Evidence from Turkey

    OpenAIRE

    Oguzhan BAHADIR; Buke TOLGA

    2013-01-01

    Although one of the main purposes of International Accounting Standards Board (IASB) is to improve comparability of financial statements by eliminating different accounting treatments applied by companies, International Financial Reporting Standards (IFRSs) still permit choices in accounting treatment of similar transactions and events. This paper examines the accounting choices made by Turkish listed companies in cases where IFRSs permit a choice between alternative accounting policies. The ...

  3. Current treatment options for the management of esophageal cancer

    Directory of Open Access Journals (Sweden)

    Mawhinney MR

    2012-11-01

    Full Text Available Mark R Mawhinney, Robert E GlasgowDepartment of Surgery, Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USAAbstract: In recent years, esophageal cancer characteristics and management options have evolved significantly. There has been a sharp increase in the frequency of esophageal adenocarcinoma and a decline in the frequency of squamous cell carcinoma. A more comprehensive understanding of prognostic factors influencing outcome has also been developed. This has led to more management options for esophageal cancer at all stages than ever before. A multidisciplinary, team approach to management in a high volume center is the preferred approach. Each patient should be individually assessed based on type of cancer, local or regional involvement, and his or her own functional status to determine an appropriate treatment regimen. This review will discuss management of esophageal cancer relative to disease progression and patient functional status.Keywords: esophageal adenocarcinoma, squamous cell carcinoma, treatment regimen, disease progression, patient functional status

  4. Disordered Gambling in Finland : Epidemiology and a Current Treatment Option

    OpenAIRE

    2013-01-01

    Disordered gambling is a multifaceted phenomenon, and consequently many factors have a role in its development and maintenance. Adverse consequences of disordered gambling can be mental, social and legal. Only a few epidemiological studies of disordered gambling have previously been conducted in Finland, and none of these studies have been published internationally. Gambling research in Finland has increased during the past years, especially the investigation of treatment options for disorder...

  5. Seasonal affective disorder, winter type: current insights and treatment options

    Directory of Open Access Journals (Sweden)

    Meesters Y

    2016-11-01

    Full Text Available Ybe Meesters,1 Marijke CM Gordijn,2,3 1University Center for Psychiatry, University Medical Center Groningen, 2Department of Chronobiology, GeLifes, University of Groningen, Groningen, the Netherlands; 3Chrono@Work B.V., Groningen, the Netherlands Abstract: Seasonal affective disorder (SAD, winter type, is a seasonal pattern of recurrent major depressive episodes most commonly occurring in autumn or winter and remitting in spring/summer. The syndrome has been well-known for more than three decades, with light treatment being the treatment of first choice. In this paper, an overview is presented of the present insights in SAD. Description of the syndrome, etiology, and treatment options are mentioned. Apart from light treatment, medication and psychotherapy are other treatment options. The predictable, repetitive nature of the syndrome makes it possible to discuss preventive treatment options. Furthermore, critical views on the concept of SAD as a distinct diagnosis are discussed. Keywords: seasonal affective disorder, review, light treatment, medication, psychotherapy, prevention

  6. Designing a climate change policy for the international maritime transport sector: Market-based measures and technological options for global and regional policy actions

    Energy Technology Data Exchange (ETDEWEB)

    Miola, A., E-mail: apollonia.miola@jrc.ec.europa.eu [European Commission, Joint Research Centre, Institute for Environment and Sustainability, Via Enrico Fermi 2749, 21027 Ispra (Italy); Marra, M., E-mail: Marleenmarra@gmail.com [European Commission, Joint Research Centre, Institute for Environment and Sustainability, Via Enrico Fermi 2749, 21027 Ispra (Italy); Ciuffo, B., E-mail: biagio.ciuffo@jrc.ec.europa.eu [European Commission, Joint Research Centre, Institute for Environment and Sustainability, Via Enrico Fermi 2749, 21027 Ispra (Italy)

    2011-09-15

    The international maritime transport sector has a significant abatement potential and some technical improvements that reduce GHG emissions would already be profitable without any policy in place. This paper analyses in-depth the limits and opportunities of policy options currently under consideration at the international level to stimulate the sector to reduce its GHG emissions. In particular, in order for the maritime transport sector to become more environmentally friendly, the flexible nature of international market-based measures and the European Union Emission Trading Scheme provide a definite window of opportunity without placing unnecessary high burden on the sector. However, the development of a regional policy, such as at European level, for the international maritime transport sector faces several obstacles: allocation of emissions, carbon leakage, permit allocation, treatment of the great variety in ship type, size and usage, and transaction cost. Global market-based policies could overcome most of these challenges. This paper provides an in-depth analysis of the policy instruments currently under discussion to reduce the sector's burden on the environment, and focuses on economic theory, legal principles, technological options, and the political framework that together make up the basis of decision-making regarding the international maritime transport sector's climate change policies. - Highlights: > Technologies for a more environmental friendly maritime transport sector and their cost-effectiveness. > How to combine ambitious CO{sub 2} reduction goals with a sector-wide market-based policy. > Permits should be auctioned frequently and small emitters have to be excluded. > Inclusion of shipping in the EU ETS causes carbon leakage, so the policy should aim at expansion.

  7. Low-income energy policy in a restructuring electricity industry: an assessment of federal options

    Energy Technology Data Exchange (ETDEWEB)

    Baxter, L.W.

    1997-07-01

    This report identifies both the low-income energy services historically provided in the electricity industry and those services that may be affected by industry restructuring. It identifies policies that are being proposed or could be developed to address low- income electricity services in a restructured industry. It discusses potential federal policy options and identifies key policy and implementation issues that arise when considering these potential federal initiatives. To understand recent policy development at the state level, we reviewed restructuring proposals from eight states and the accompanying testimony and comments filed in restructuring proceedings in these states.

  8. Current Ground Test Options for Nuclear Thermal Propulsion (NTP)

    Science.gov (United States)

    Gerrish, Harold P., Jr.

    2014-01-01

    (approximately 1 GW) with a maximum burn time of 1 hour. The concept utilized lessons learned from NF-1. The strategy breaks down the exhaust into parallel paths to allow flexibility with engine size and mass flow of exhaust. Similar to NF-1, the exhaust is slowed down, cooled, filtered of particulates, filtered of noble gases, and then the clean hydrogen is flared to open air. Another concept proposed by Steve Howe (currently Director of the Center for Space Nuclear Research) to simplify the NTP exhaust filtering is to run the hydrogen exhaust into boreholes underground to filter the exhaust. The two borehole site locations proposed are at the NTS and at the Idaho National Laboratory (INL). At NTS, the boreholes are 8' diameter and 1200' deep. The permeability of hydrogen through the soil and its buoyancy will allow it to rise up through the soil and allow the filtering of noble gases and radioactive particulates. The exhaust needs to be cooled to 600C before entering the borehole to avoid soil glazing. Preliminary analysis shows a small buildup of back pressure with time which depends on permeability. Noble gases entering the borehole walls deep can take a long time before reaching the surface. Other factors affecting permeability include borehole pressure, water saturation, and turbulence. Also, a possible need to pump out contaminated water collected at the bottom of the borehole. At INL, the borehole concept is slightly different. The underground borehole has openings to the soil at special depths which have impermeable interbeds above the water table and below the surface to allow the exhaust to travel horizontal between the impermeable layers. Preliminary results indicate better permeability than at NTS. The last option is total containment of the exhaust during the test run. The concept involves slowing down the flow to subsonic in a water cooled diffuser. The hydrogen is burned off in an oxygen rich afterburner with the only products being steam, oxygen, and some noble

  9. Policy options for healthier retail food environments in city-regions.

    Science.gov (United States)

    Mah, Catherine L; Cook, Brian; Rideout, Karen; Minaker, Leia M

    2016-06-09

    Public policy is central to health promotion: it determines the distribution of resources in a society and establishes the structural context for the actions of both corporations and consumers. With this in mind, the purpose of this paper is to begin a discussion on promising policy options for a health-promoting retail food environment. Drawing on specific municipal examples, we examine four groups of policy options for healthier retail food environments in city-regions: planning for health; transforming consumer environments; economic and fiscal instruments; and a culture of transparency and participation. We introduce examples of policy options that are receiving increasing attention in the public health and urban planning literature and that function at the municipal level. We also highlight how public health professionals have an important role to play in policy that shapes retail food environments, especially in making explicit the linkages between health and other policy goals. In doing so, this commentary aims to motivate public health practitioners in a variety of community contexts to consider the policy supports they need to advance their exploration, development, testing and evaluation of interventions for healthier retail food environments.

  10. Policy options for pharmaceutical pricing and purchasing: issues for low- and middle-income countries.

    Science.gov (United States)

    Nguyen, Tuan Anh; Knight, Rosemary; Roughead, Elizabeth Ellen; Brooks, Geoffrey; Mant, Andrea

    2015-03-01

    Pharmaceutical expenditure is rising globally. Most high-income countries have exercised pricing or purchasing strategies to address this pressure. Low- and middle-income countries (LMICs), however, usually have less regulated pharmaceutical markets and often lack feasible pricing or purchasing strategies, notwithstanding their wish to effectively manage medicine budgets. In high-income countries, most medicines payments are made by the state or health insurance institutions. In LMICs, most pharmaceutical expenditure is out-of-pocket which creates a different dynamic for policy enforcement. The paucity of rigorous studies on the effectiveness of pharmaceutical pricing and purchasing strategies makes it especially difficult for policy makers in LMICs to decide on a course of action. This article reviews published articles on pharmaceutical pricing and purchasing policies. Many policy options for medicine pricing and purchasing have been found to work but they also have attendant risks. No one option is decisively preferred; rather a mix of options may be required based on country-specific context. Empirical studies in LMICs are lacking. However, risks from any one policy option can reasonably be argued to be greater in LMICs which often lack strong legal systems, purchasing and state institutions to underpin the healthcare system. Key factors are identified to assist LMICs improve their medicine pricing and purchasing systems. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine © The Author 2014; all rights reserved.

  11. Economic and Environmental Evaluation of Farm Bill Policy Options Using the CEEPES-FAPRI Modeling System, An

    OpenAIRE

    P. G. Lakshminarayan; Bruce A. Babcock

    1995-01-01

    This report estimates the economic and environmental trade-offs of the 1995 Farm Bill policy options evaluated by FAPRI. Assessments are provided for the 1995 FAPRI baseline, 25 percent Normal Flex, and the Revenue Assurance program. The authors describe the modeling systems and the CEEPES-FAPRI linkage, delineate the policy options and their likely economic and environmental impacts, and discuss predicted economic and environmental impacts of these policy options.

  12. REDD+ and the global economy; Competing forces and policy options

    NARCIS (Netherlands)

    Pacheco, P.; Putzel, L.; Obidzinski, K.; Schoneveld, G.C.

    2012-01-01

    The challenges of reducing greenhouse gas (GHG) emissions, while feeding a growing population and meeting global demand for fibre and energy, are attracting increasing attention (Kissinger 2011; Wollenberg et al. 2011). This chapter presents an overview of current trade and investment-related driver

  13. Public health economic evaluation of different European Union-level policy options aimed at reducing population dietary trans fat intake.

    Science.gov (United States)

    Martin-Saborido, Carlos; Mouratidou, Theodora; Livaniou, Anastasia; Caldeira, Sandra; Wollgast, Jan

    2016-11-01

    The adverse relation between dietary trans fatty acid (TFA) intake and coronary artery disease risk is well established. Many countries in the European Union (EU) and worldwide have implemented different policies to reduce the TFA intake of their populations. The aim of this study was to assess the added value of EU-level action by estimating the cost-effectiveness of 3 possible EU-level policy measures to reduce population dietary TFA intake. This was calculated against a reference situation of not implementing any EU-level policy (i.e., by assuming only national or self-regulatory measures). We developed a mathematical model to compare different policy options at the EU level: 1) to do nothing beyond the current state (reference situation), 2) to impose mandatory TFA labeling of prepackaged foods, 3) to seek voluntary agreements toward further reducing industrially produced TFA (iTFA) content in foods, and 4) to impose a legislative limit for iTFA content in foods. The model indicated that to impose an EU-level legal limit or to make voluntary agreements may, over the course of a lifetime (85 y), avoid the loss of 3.73 and 2.19 million disability-adjusted life-years (DALYs), respectively, and save >51 and 23 billion euros when compared with the reference situation. Implementing mandatory TFA labeling can also avoid the loss of 0.98 million DALYs, but this option incurs more costs than it saves compared with the reference option. The model indicates that there is added value of an EU-level action, either via a legal limit or through voluntary agreements, with the legal limit option producing the highest additional health benefits. Introducing mandatory TFA labeling for the EU common market may provide some additional health benefits; however, this would likely not be a cost-effective strategy.

  14. Curbing International Piracy of Intellectual Property. Policy Options for a Major Exporting Country.

    Science.gov (United States)

    Hoffman, Gary M.; Marcou, George T.

    This report of the International Piracy Project addresses three major topics: (1) The Costs and Complications of Piracy; (2) Rights Enforcement Today; and (3) Policy Options for Curbing Piracy. The first section discusses piracy of copyrights, patents, and other intellectual property, including economic losses and damage to the finances and…

  15. Income distribution policy options amid the global financial crisis

    Institute of Scientific and Technical Information of China (English)

    朱玲; 金成武

    2009-01-01

    This statistics-based study shows that in China the urban-rural income gap is contributing more to general income inequality than regional income gaps are. The regional income disparity sets in an east-west plus central contrast while the urban-rural gap is most significantly present in the west and central areas between the cities and the countryside. Rural migrant laborers have helped shrink the urban-rural and regional income gaps. However, when the economy is hit by the global financial crisis to slow, a number of public actions are crucial and urgent to reduce income inequality and enhance social stability. The actions would include an immediate social bail-out and provisions for social security for rural-based migrants currently working in the cities, employment programs targeting low-income group as well as encouraging entrepreneurship.

  16. Advanced policy options to regulate sugar-sweetened beverages to support public health.

    Science.gov (United States)

    Pomeranz, Jennifer L

    2012-02-01

    Consumption of sugar-sweetened beverages (SSBs) has increased worldwide. As public health studies expose the detrimental impact of SSBs, consumer protection and public health advocates have called for increased government control. A major focus has been on restricting marketing of SSBs to children, but many innovative policy options--legally defensible ways to regulate SSBs and support public health--are largely unexplored. We describe the public health, economic, and retail marketing research related to SSBs (including energy drinks). We review policy options available to governments, including mandatory factual disclosures, earmarked taxation, and regulating sales, including placement within retail and food service establishments, and schools. Our review describes recent international initiatives and classifies options available in the United States by jurisdiction (federal, state, and local) based on legal viability.

  17. Cancer immunotherapy in veterinary medicine: Current options and new developments.

    Science.gov (United States)

    Regan, Daniel; Guth, Amanda; Coy, Jonathan; Dow, Steven

    2016-01-01

    Excitement in the field of tumor immunotherapy is being driven by several remarkable breakthroughs in recent years. This review will cover recent advances in cancer immunotherapy, including the use of T cell checkpoint inhibitors, engineered T cells, cancer vaccines, and anti-B cell and T cell antibodies. Inhibition of T cell checkpoint molecules such as PD-1 and CTLA-4 using monoclonal antibodies has achieved notable success against advanced tumors in humans, including melanoma, renal cell carcinoma, and non-small cell lung cancer. Therapy with engineered T cells has also demonstrated remarkable tumor control and regression in human trials. Autologous cancer vaccines have recently demonstrated impressive prolongation of disease-free intervals and survival times in dogs with lymphoma. In addition, caninized monoclonal antibodies targeting CD20 and CD52 just recently received either full (CD20) or conditional (CD52) licensing by the United States Department of Agriculture for clinical use in the treatment of canine B-cell and T-cell lymphomas, respectively. Thus, immunotherapy for cancer is rapidly moving to the forefront of cancer treatment options in veterinary medicine as well as human medicine.

  18. Current options for the treatment of optic neuritis

    Directory of Open Access Journals (Sweden)

    Pula JH

    2012-07-01

    Full Text Available John H Pula,1 Christopher J MacDonald21Division of Neuro-ophthalmology, University of Illinois College of Medicine at Peoria, Peoria; 2University of Illinois College of Medicine at Urbana-Champaign, Champaign, IL, USAAbstract: Optic neuritis can be defined as typical (associated with multiple sclerosis, improving independent of steroid treatment, or atypical (not associated with multiple sclerosis, steroid-dependent improvement. Causes of atypical optic neuritis include connective tissue diseases (eg, lupus, vasculitis, sarcoidosis, or neuromyelitis optica. In this manuscript, updated treatment options for both typical and atypical optic neuritis are reviewed. Conventional treatments, such as corticosteroids, therapeutic plasma exchange, and intravenous immunoglobulin therapy are all discussed with commentary regarding evidence-based outcomes. Less commonly used treatments and novel purported therapies for optic neuritis are also reviewed. Special scenarios in the treatment of optic neuritis – pediatric optic neuritis, acute demyelinating encephalomyelitis, and optic neuritis occurring during pregnancy – are specifically examined.Keywords: optic neuritis, optic neuropathy, treatment, neuroophthalmology

  19. Curative treatment of oesophageal carcinoma: current options and future developments

    Directory of Open Access Journals (Sweden)

    Bruns Christiane

    2011-05-01

    Full Text Available Abstract Since the 1980s major advances in surgery, radiotherapy and chemotherapy have established multimodal approaches as curative treatment options for oesophageal cancer. In addition the introduction of functional imaging modalities such as PET-CT created new opportunities for a more adequate patient selection and therapy response assessment. The majority of oesophageal carcinomas are represented by two histologies: squamous cell carcinoma and adenocarcinoma. In recent years an epidemiological shift towards the latter was observed. From a surgical point of view, adenocarcinomas, which are usually located in the distal third of the oesophagus, may be treated with a transhiatal resection, whereas squamous cell carcinomas, which are typically found in the middle and the upper third, require a transthoracic approach. Since overall survival after surgery alone is poor, multimodality approaches have been developed. At least for patients with locally advanced tumors, surgery alone can no longer be advocated as routine treatment. Nowadays, scientific interest is focused on tumor response to induction radiochemotherapy. A neoadjuvant approach includes the early and accurate assessment of clinical response, optimally performed by repeated PET-CT imaging and endoscopic ultrasound, which may permit early adaption of the therapeutic concept. Patients with SCC that show clinical response by PET CT are considered to have a better prognosis, regardless of whether surgery will be performed or not. In non-responding patients salvage surgery improves survival, especially if complete resection is achieved.

  20. Allergic contact dermatitis in preservatives: current standing and future options.

    Science.gov (United States)

    Deza, Gustavo; Giménez-Arnau, Ana M

    2017-08-01

    Preservatives are well known skin sensitizers and represent one of the main causes of contact allergy. The purpose of this article is to review the current state of contact sensitization induced by preservatives and point future alternatives for products' preservation. Isothiazolinones currently are the most common preservatives responsible of contact allergy in Europe and in the United States, and although some regulatory interventions have been taken place, the current contact allergy outbreak is not yet under control. Despite the ban of methyldibromo glutaronitrile from cosmetics in Europe, sensitized patients are still diagnosed, suggesting other nonregulated sources of exposure. Sensitization rates to formaldehyde and formaldehyde-releasers are lower in Europe in comparison with the United States due to stricter regulations regarding their use. Prevalence of contact allergy to parabens has remained stable over the last decades, whereas iodopropynyl butylcarbamate is an emerging allergen with an increasing prevalence. Future alternatives for products' preservation look for a broad antimicrobial spectrum, but with a better safety profile (in terms of sensitization) than the currently available compounds. Given the high rates of sensitization reported over the last years, timely regulatory actions are urgently required for some preservatives that currently represent a concern for public health.

  1. Sharing the Caring: Rethinking Current Policies.

    Science.gov (United States)

    Edgar, Don

    1992-01-01

    This article presents an argument for reforming Australian public policy in favor of social care, rather than family, residential, or community care, for the elderly, sick, and disabled. After noting policy assumptions that families are the focus of caring and women are the natural caregivers, the paper describes changes in Australian family…

  2. Stemming the impact of health professional brain drain from Africa: a systemic review of policy options

    Directory of Open Access Journals (Sweden)

    Edward Zimbudzi

    2013-06-01

    Full Text Available Africa has been losing professionally trained health workers who are the core of the health system of this continent for many years. Faced with an increased burden of disease and coupled by a massive exodus of the health workforce, the health systems of many African nations are risking complete paralysis. Several studies have suggested policy options to reduce brain drain from Africa. The purpose of this paper is to review possible policies, which can stem the impact of health professional brain drain from Africa. A systemic literature review was conducted. Cinahl, Science Direct and PubMed databases were searched with the following terms: health professional brain drain from Africa and policies for reducing impact of brain drain from Africa. References were also browsed for relevant articles. A total of 425 articles were available for the study but only 23 articles met the inclusion criteria. The review identified nine policy options, which were being implemented in Africa, but the most common was task shifting which had success in several African countries. This review has demonstrated that there is considerable consensus on task shifting as the most appropriate and sustainable policy option for reducing the impact of health professional brain drain from Africa.

  3. Review of current and emerging treatment options in acromegaly.

    Science.gov (United States)

    Muhammad, A; van der Lely, A J; Neggers, S J C M M

    2015-10-01

    In almost every patient, acromegaly is caused by a growth hormone secreting pituitary adenoma. Clinical features are the result of excessive growth hormone secretion and the consecutive excess in insulin-like growth factor I levels. This results in somatic overgrowth and metabolic disturbances with a higher morbidity and mortality than in the general population. With optimal disease management, mortality can be reduced to that seen in the general population. The current treatment of acromegaly is based on a combination of surgery, radiotherapy and medical therapy. This review provides an overview of the current and upcoming therapies with a focus on medical therapy.

  4. Management of patients with resistant hypertension: current treatment options

    Directory of Open Access Journals (Sweden)

    Kumar N

    2013-10-01

    options to treat RHTN.Keywords: RHTN, blood pressure, chlorthalidone, hydrochlorothiazide, baroreflex activation, renal denervation, aldosterone, heart failure, renovascular, obstructive sleep apnea

  5. Using economic policy to tackle chronic disease: options for the Australian Government.

    Science.gov (United States)

    Kaplin, Lauren; Thow, Anne Marie

    2013-03-01

    Australia suffers from one of the highest prevalences among developed countries of persons being overweight and obese, these conditions arising from the overconsumption of energy-dense, nutrient-poor foods that are generally less expensive than healthier options. One potential avenue for intervention is to influence the price of foods such that healthier options are less expensive and, therefore, are an easier choice to make. This article considers the potential for fiscal policies that would realign food prices with health incentives. Through a review of consumption taxes, consumer subsidies, trade policies, agricultural support policies, and other incentive programs as possible avenues for intervention, this article asks what the Commonwealth Government has already done to help improve Australian diets, and looks at where further improvements could be made.

  6. Optimization on bicriterion policies for M/G/1 system with second optional service

    Institute of Scientific and Technical Information of China (English)

    Jau-chuan KE; Yunn-kuang CHU

    2008-01-01

    We compare the optimal operating cost of the two bicriterion policies, p,T and p,N, for an M/G/1 queueing system with second optional service, in which the length of the vacation period is randomly controlled either by the number of arrivals during the idle period or by a timer. After all the customers are served in the queue exhaustively, the server immediately takes a vacation and may operate p, T policy or p,N policy. For the two bicriterion policies, the total average cost function per unit time is developed to search the optimal stationary operating policies at a minimum cost. Based upon the optimal cost the explicit forms for joint optimum threshold values of (p,T) and (p,N) are obtained.

  7. Post-traumatic epilepsy: current and emerging treatment options

    Directory of Open Access Journals (Sweden)

    Szaflarski JP

    2014-08-01

    Full Text Available Jerzy P Szaflarski,1,3 Yara Nazzal,1,3 Laura E Dreer2 1Department of Neurology, 2Department of Ophthalmology, 3UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: Traumatic brain injury (TBI leads to many undesired problems and complications, including immediate and long-term seizures/epilepsy, changes in mood, behavioral, and personality problems, cognitive and motor deficits, movement disorders, and sleep problems. Clinicians involved in the treatment of patients with acute TBI need to be aware of a number of issues, including the incidence and prevalence of early seizures and post-traumatic epilepsy (PTE, comorbidities associated with seizures and anticonvulsant therapies, and factors that can contribute to their emergence. While strong scientific evidence for early seizure prevention in TBI is available for phenytoin (PHT, other antiepileptic medications, eg, levetiracetam (LEV, are also being utilized in clinical settings. The use of PHT has its drawbacks, including cognitive side effects and effects on function recovery. Rates of recovery after TBI are expected to plateau after a certain period of time. Nevertheless, some patients continue to improve while others deteriorate without any clear contributing factors. Thus, one must ask, ‘Are there any actions that can be taken to decrease the chance of post-traumatic seizures and epilepsy while minimizing potential short- and long-term effects of anticonvulsants?’ While the answer is ‘probably,’ more evidence is needed to replace PHT with LEV on a permanent basis. Some have proposed studies to address this issue, while others look toward different options, including other anticonvulsants (eg, perampanel or other AMPA antagonists, or less established treatments (eg, ketamine. In this review, we focus on a comparison of the use of PHT versus LEV in the acute TBI setting and summarize the clinical aspects of seizure prevention in humans with

  8. Current Standards and Novel Treatment Options for Metastatic Pancreatic Adenocarcinoma.

    Science.gov (United States)

    Weinberg, Benjamin A; Yabar, Cinthya S; Brody, Jonathan R; Pishvaian, Michael J

    2015-11-01

    Pancreatic cancer is one of the most lethal solid tumors. The prognosis of metastatic pancreatic adenocarcinoma remains dismal, with a median survival of less than 1 year, due in large part to the fact that pancreatic adenocarcinoma is notoriously refractory to chemotherapy. However, there recently have been significant improvements in outcomes for patients with pancreatic adenocarcinoma: ongoing trials have shown promise, and these may lead to still further progress. Here we review the current treatment paradigms for metastatic disease, focusing on ways to ameliorate symptoms and lengthen survival. We then summarize recent advances in our understanding of the molecular and cellular aspects of pancreatic cancer. Finally, we outline new approaches currently under development for the treatment of metastatic disease, arising from our improved understanding of the genetic and nongenetic alterations within pancreatic cancer cells-and of interactions between cancer cells, the tumor microenvironment, and the immune system.

  9. Policy Options for Addressing Health System and Human Resources for Health Crisis in Liberia Post-Ebola Epidemic.

    Science.gov (United States)

    Budy, Fidel C T

    2015-01-01

    Qualified healthcare workers within an effective health system are critical in promoting and achieving greater health outcomes such as those espoused in the Millennium Development Goals. Liberia is currently struggling with the effects of a brutal 14-year long civil war that devastated health infrastructures and caused most qualified health workers to flee and settle in foreign countries. The current output of locally trained health workers is not adequate for the tasks at hand. The recent Ebola Virus Disease (EVD) exposed the failings of the Liberian healthcare system. There is limited evidence of policies that could be replicated in Liberia to encourage qualified diaspora Liberian health workers to return and contribute to managing the phenomenon. This paper reviews the historical context for the human resources for health crisis in Liberia; it critically examines two context-specific health policy options to address the crisis, and recommends reverse brain drain as a policy option to address the immediate and critical crisis facing the health care sector in Liberia.

  10. CURRENT OPTIONS IN TREATMENT OF FISTULA-IN-ANO

    Directory of Open Access Journals (Sweden)

    Mohanlal Khadia

    2016-08-01

    Full Text Available Fistula-in-ano has long been notorious for its tendency to recur after operation. Although surgery remains the main modality of treatment, still no clear recommendations are available and its treatment is still debatable. Treating anal fistula remains a challenging issue because of the anatomical location, the potential risks of septic complications and postoperative stool incontinence. Nowadays several sphincter sparing procedures are preferred, but they carry their own risk of recurrence and some degree of incontinence. So here we will discuss current procedures used in treatment of different types of fistula-in-ano.

  11. Obesity and asthma in children: current and future therapeutic options.

    Science.gov (United States)

    Lang, Jason E

    2014-06-01

    With the childhood prevalence of obesity and asthma increasing, it is important for pediatric professionals to appreciate that obesity modifies the diagnosis and management of asthma. These disease modifications present challenges to clinical management, including decreased responsiveness to controller therapy and decreased quality of life compared with normal-weight asthmatic children. While consensus guidelines do not currently suggest specific changes in asthma management for obese patients, management of some patients may be improved with consideration of the latest evidence. This article briefly summarizes what is known regarding the complex relationship between obesity and asthma in children, and discusses practical issues associated with the diagnosis and effective clinical management of asthma in obese children. On average, obese patients with asthma do not respond as well to inhaled corticosteroid therapy. Management approaches including weight loss and routine exercise are safe, and may improve important asthma outcomes. Asthma providers should learn to facilitate weight loss for their obese patients. In addition, pharmacologic interventions for weight loss in obese asthma, though not currently recommended, may soon be considered.

  12. Carbon accounting of forest bioenergy: from model calibrations to policy options (Invited)

    Science.gov (United States)

    Lamers, P.

    2013-12-01

    Programs to stimulate biomass use for the production of heating/cooling and electricity have been implemented in many countries as part of their greenhouse gas emission reduction strategies. Critiques claim however that the use of forest biomass, e.g. as a replacement of hard-coal in large-scale power plants or mineral oil fuelled residential heating boilers, countervails carbon saving and thus also climate change mitigation strategies, at least in the short-term, as forest biomass combustion releases previously stored biogenic carbon back into the atmosphere. While there seems general agreement that carbon emitted from bioenergy combustion was and will again be sequestered from the atmosphere given a sustainable biomass management system, there is inherent concern that carbon release and sequestration rates may not be in temporal balance with each other and eventually jeopardize mid-century carbon/temperature/climate targets. So far, biomass carbon accounting systems (including those that are part of regulatory standards) have not incorporated this potential temporal imbalance or ';carbon debt'. The potential carbon debt caused by wood harvest and the resulting time spans needed to reach pre-harvest carbon levels (payback) or those of a reference case (parity) have become important parameters for climate and bioenergy policy developments. The present range of analyses however varies in assumptions, regional scopes, and conclusions. Policy makers are confronted with this portfolio while needing to address the temporal carbon aspect in current regulations. In order to define policies for our carbon constrained world, it is critical to better understand the dimensions and regional differences of these carbon cycles. This paper/presentation discusses to what extent and under which circumstances (i.e. bioenergy systems) a temporal forest carbon imbalance could jeopardize future temperature and eventually climate targets. It further reviews the current state of

  13. Current management options for latent tuberculosis: a review

    Directory of Open Access Journals (Sweden)

    Norton BL

    2012-11-01

    Full Text Available Brianna L Norton, David P HollandDepartment of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USAAbstract: Tuberculosis remains the world’s second leading infectious cause of death, with nearly one-third of the global population latently infected. Treatment of latent tuberculosis infection is a mainstay of tuberculosis-control efforts in low-to medium-incidence countries. Isoniazid monotherapy has been the standard of care for decades, but its utility is impaired by poor completion rates. However, new, shorter-course regimens using rifamycins improve completion rates and are cost-saving compared with standard isoniazid monotherapy. We review the currently available therapies for latent tuberculosis infection and their toxicities and include a brief economic comparison of the different regimens.Keywords: isoniazid, rifampin, rifapentine, tuberculin skin test, interferon-gamma release assay

  14. Current and emerging options for the drug treatment of narcolepsy.

    Science.gov (United States)

    De la Herrán-Arita, Alberto K; García-García, Fabio

    2013-11-01

    Narcolepsy/hypocretin deficiency (now called type 1 narcolepsy) is a lifelong neurologic disorder with well-established diagnostic criteria and etiology. Narcolepsy is a chronic sleep disorder characterized by excessive daytime sleepiness (EDS) and symptoms of dissociated rapid eye movement sleep such as cataplexy (sudden loss of muscle tone), hypnagogic hallucinations (sensory events that occur at the transition from wakefulness to sleep), sleep paralysis (inability to perform movements upon wakening or sleep onset), and nocturnal sleep disruption. As these symptoms are often disabling, most patients need life-long treatment. The treatment of narcolepsy is well defined, and, traditionally, amphetamine-like stimulants (i.e., dopaminergic release enhancers) have been used for clinical management to improve EDS and sleep attacks, whereas tricyclic antidepressants have been used as anticataplectics. However, treatments have evolved to better-tolerated compounds such as modafinil or armodafinil (for EDS) and adrenergic/serotonergic selective reuptake inhibitors (as anticataplectics). In addition, night-time administration of a short-acting sedative, c-hydroxybutyrate (sodium oxybate), has been used for the treatment for EDS and cataplexy. These therapies are almost always needed in combination with non-pharmacologic treatments (i.e., behavioral modification). A series of new drugs is currently being tested in animal models and in humans. These include a wide variety of hypocretin agonists, melanin- concentrating hormone receptor antagonists, antigenspecific immunopharmacology, and histamine H3 receptor antagonists/inverse agonists (e.g., pitolisant), which have been proposed for specific therapeutic applications, including the treatment of Alzheimer's disease, attention-deficit hyperactivity disorder, epilepsy, and more recently, narcolepsy. Even though current treatment is strictly symptomatic, based on the present state of knowledge of the pathophysiology of

  15. Current and emerging treatment options for hairy cell leukemia

    Directory of Open Access Journals (Sweden)

    López-Rubio M

    2015-08-01

    Full Text Available Montserrat López-Rubio,1 Jose Antonio Garcia-Marco2 1Department of Hematology, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, 2Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain Abstract: Hairy cell leukemia (HCL is a lymphoproliferative B-cell disorder characterized by pancytopenia, splenomegaly, and characteristic cytoplasmic hairy projections. Precise diagnosis is essential in order to differentiate classic forms from HCL variants, such as the HCL-variant and VH4-34 molecular variant, which are more resistant to available treatments. The current standard of care is treatment with purine analogs (PAs, such as cladribine or pentostatin, which provide a high rate of long-lasting clinical remissions. Nevertheless, ~30%–40% of the patients relapse, and moreover, some of these are difficult-to-treat refractory cases. The use of the monoclonal antibody rituximab in combination with PA appears to produce even higher responses, and it is often employed to minimize or eliminate residual disease. Currently, research in the field of HCL is focused on identifying novel therapeutic targets and potential agents that are safe and can universally cure the disease. The discovery of the BRAF mutation and progress in understanding the biology of the disease has enabled the scientific community to explore new therapeutic targets. Ongoing clinical trials are assessing various treatment strategies such as the combination of PA and anti-CD20 monoclonal antibodies, recombinant immunotoxins targeting CD22, BRAF inhibitors, and B-cell receptor signal inhibitors. Keywords: hairy cell leukemia, purine analogs, rituximab, immunotoxins, vemurafenib, ibrutinib

  16. Current pharmacotherapy options for cancer anorexia and cachexia.

    Science.gov (United States)

    Macciò, Antonio; Madeddu, Clelia; Mantovani, Giovanni

    2012-12-01

    Anorexia and cachexia syndrome represents a complex clinical picture that occurs in the late stage of several chronic inflammatory diseases, including cancer. Unless counteracted cancer-related anorexia and cachexia syndrome affects quality of life (QL) and survival. However, to date a standard effective treatment is lacking. The aim of this review is to describe the current pharmacological approaches for anorexia and cachexia syndrome, focusing on cancer-related syndrome. The several pharmacological agents tested so far are discussed, distinguishing them in unproven drugs, effective drugs, and drugs under investigation. Moreover, a section is devoted to the promising use of nutritional supplements and nutraceuticals. The emerging role of a multitargeted combined treatment approach is exhaustively reviewed. Considering the complex clinical picture and the multifactorial pathogenesis of anorexia and cachexia syndrome, we believe that its clinical management requires a multidisciplinary and multipharmacological approach. In our opinion the anorexia and cachexia syndrome treatment should include drugs that target the following conditions: inflammatory status, oxidative stress, nutritional disorders, muscle catabolism, anemia, immunosuppression, and fatigue. The multidimensional therapies for anorexia and cachexia syndrome should ideally be introduced within a context of the "best supportive care," which includes optimal symptom management and careful psychosocial counseling.

  17. Managing pediatric hepatitis C: current and emerging treatment options

    Directory of Open Access Journals (Sweden)

    Wikrom Karnsakul

    2009-08-01

    Full Text Available Wikrom Karnsakul, Mary Kay Alford, Kathleen B SchwarzPediatric Liver Center, Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins School of Medicine, Baltimore, MD, USAAbstract: Since 1992, the maternal–fetal route of transmission has become the dominant route for acquisition of hepatitis C (HCV infection by children. With increasing knowledge of antiviral treatment for HCV infection, the main goal of therapy is to achieve a sustained virological response (SVR as defined by undetectable serum HCV RNA by polymerase chain reaction assay six months after cessation of therapy. In young children, interferon therapy is more effective than in adults with chronic HCV infection (CHC. Although children clearly have a milder degree of liver pathology, data have indicated that hepatic inflammation from HCV infection can progress to fibrosis or cirrhosis in children. Hepatocellular carcinoma has been reported in adolescents with CHC. In this article, recent improvements in therapy of children with CHC and in the clinical development of new emerging drugs with potential use in children will be reviewed.Keywords: chronic hepatitis C, children, current therapy, pegylated interferon

  18. Current and emerging treatment options in the management of lupus

    Directory of Open Access Journals (Sweden)

    Jordan N

    2016-03-01

    Full Text Available Natasha Jordan,1 David D’Cruz2 1Department of Rheumatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, 2Louise Coote Lupus Unit, Guy’s and St Thomas’ Hospital NHS Foundation Trust, London, UK Abstract: Systemic lupus erythematosus (SLE is a complex autoimmune disease with variable clinical manifestations. While the clearest guidelines for the treatment of SLE exist in the context of lupus nephritis, patients with other lupus manifestations such as neuropsychiatric, hematologic, musculoskeletal, and severe cutaneous lupus frequently require immunosuppression and/or biologic therapy. Conventional immunosuppressive agents such as mycophenolate mofetil, azathioprine, and cyclophosphamide are widely used in the management of SLE with current more rationalized treatment regimens optimizing the use of these agents while minimizing potential toxicity. The advent of biologic therapies has advanced the treatment of SLE particularly in patients with refractory disease. The CD20 monoclonal antibody rituximab and the anti-BLyS agent belimumab are now widely in use in clinical practice. Several other biologic agents are in ongoing clinical trials. While immunosuppressive and biologic agents are the foundation of inflammatory disease control in SLE, the importance of managing comorbidities such as cardiovascular risk factors, bone health, and minimizing susceptibility to infection should not be neglected. Keywords: hydroxychloroquine, mycophenolate mofetil, azathioprine, cyclophosphamide, rituximab, belimumab

  19. Current and emerging treatment options in the management of lupus.

    Science.gov (United States)

    Jordan, Natasha; D'Cruz, David

    2016-01-01

    Systemic lupus erythematosus (SLE) is a complex autoimmune disease with variable clinical manifestations. While the clearest guidelines for the treatment of SLE exist in the context of lupus nephritis, patients with other lupus manifestations such as neuropsychiatric, hematologic, musculoskeletal, and severe cutaneous lupus frequently require immunosuppression and/or biologic therapy. Conventional immunosuppressive agents such as mycophenolate mofetil, azathioprine, and cyclophosphamide are widely used in the management of SLE with current more rationalized treatment regimens optimizing the use of these agents while minimizing potential toxicity. The advent of biologic therapies has advanced the treatment of SLE particularly in patients with refractory disease. The CD20 monoclonal antibody rituximab and the anti-BLyS agent belimumab are now widely in use in clinical practice. Several other biologic agents are in ongoing clinical trials. While immunosuppressive and biologic agents are the foundation of inflammatory disease control in SLE, the importance of managing comorbidities such as cardiovascular risk factors, bone health, and minimizing susceptibility to infection should not be neglected.

  20. Do current European policies support soil multifunctionality?

    Science.gov (United States)

    Helming, Katharina; Glaesner, Nadia; de Vries, Wim

    2017-04-01

    Soils are multifunctional. Maximising one function, e.g. production of biomass, is often at the costs of the other functions, e.g. water purification, carbon sequestration, nutrient recycling, habitat provision. Sustainable soil management actually means the minimization of trade-offs between multiple soil functions. While Europe does not have a policy that explicitly focuses on soil functions, a number of policies exist in the agricultural, environmental and climate domains that may affect soil functions, in particular food production, water purification, climate change mitigation, biodiversity conservation. The objective of this study was to identify gaps and overlaps in existing EU legislation that is related to soil functions. We conducted a cross-policy analysis of 19 legislative policies at European level. Results revealed two key findings: (i) soil functions are addressed in existing legislation but with the approach to their conservation rather than their improvement. (ii) Different legislations addressed isolated soil functions but there is no policy in place that actually addressed the soil multifunctionality, which is the integrated balancing of the multitude of functions. Because soil degradation is ongoing in Europe, it raises the question whether existing legislation is sufficient for maintaining soil resources and achieving sustainable soil management. Addressing soil functions individually in various directives fails to account for the multifunctionality of soil. Here, research has a role to play to better reveal the interacting processes between soil functions and their sensitivity to soil management decisions and to translate such understanding into policy recommendation. We conclude the presentation with some insights into a research approach that integrates the soil systems into the socio-economic systems to improve the understanding of soil management pressures, soil functional reactions and their impacts on societal value systems, including

  1. Diagnostic approach and current treatment options in childhood vasculitis.

    Science.gov (United States)

    Barut, Kenan; Şahin, Sezgin; Adroviç, Amra; Kasapçopur, Özgür

    2015-12-01

    All inflammatory changes in the vessel wall are defined as vasculitis. Pediatric vasculitis may present with different clinical findings. Although Henoch-Schönlein purpura which is the most common pediatric vasculitis generally recovers spontaneously, it should be monitorized closely because of the risk of renal failure. Although Kawasaki disease is easy to diagnose with its classical findings, the diagnosis may be delayed in case of incomplete Kawasaki disease. Kawasaki disease should be considered especially in infants in case of prolonged fever even if the criteria are not fully met and intravenous immunoglobulin treatment should be administered without delay in order to prevent development of coronary artery aneurism. Reaction at the site of administration of Bacillus Calmette-Guerin (BCG) vaccine may be observed as commonly as cervical lymphadenopathy in Kawasaki disease and may be used as a valuable finding in suspicious cases. Although anti-neutrophil cytoplasmic antibody-associated vasculitides are rare in children, renal involvement is more common and progression is more severe compared to adults. Hence, efficient and aggressive treatment is required. Takayasu's arteritis is observed commonly in young adult women and rarely in adolescent girls. Therefore, a careful physical examination and blood pressure measurement should be performed in addition to a detailed history in daily practice. In children with unexplained neurological findings, cerebral vasculitis should be considered in the absence of other systemic vasculitides and necessary radiological investigations should be performed in this regard. This review will provide an insight into the understanding of pediatric vasculitis, current diagnostic approaches and prognosis by the aid of new studies.

  2. The Phoenix Mission and its Current Landing Site options

    Science.gov (United States)

    Tamppari, LK; Smith, P.; Arvidson, RE; Phoenix Team

    2005-08-01

    Phoenix is the 2007 Mars Scout program mission that will send a lander and suite of instruments to study the north polar region on Mars. Central goals for the Phoenix mission are to study the recent history of water as written into the high latitude soils and to search for habitable zones. In order to do this, Phoenix carries a comprehensive suite of seven instruments. This suite includes 3 cameras, an optical microscope and an atomic-force microscope, allowing imaging at spatial scales ranging from kms, for large scale geomorphological studies, to microns, for examining single grain sizes and shapes. Phoenix also has a meteorology suite, which includes atmospheric temperature measurements at 3 levels, atmospheric pressure, and an upward-looking lidar, for dust and water-ice cloud detection. A robotic arm will dig a trench into the surface near the lander to collect and deliver samples to on-board chemistry and mineralogy experiments. These experiments will allow the detection of the mineral makeup of the soil as well as its water content, pH, salt content, and organic content. An important aspect of this exciting mission is the selection of the landing site, within the 65-72 deg N latitude band. Both science and safety concerns will play into this selection. Work is ongoing to determine the most favorable location, with consideration focusing on the best ice/soil ratio, the shallowest slopes and fewest large rocks. Current sites under consideration will be discussed. Selected in 2003, Phoenix was recently confirmed to proceed into Phase C/D of spacecraft development. This research was funded by a NASA Grant and carried out by the Jet Propulsion Laboratory, California Institute of Technology.

  3. Working Children: Current Trends and Policy Responses.

    Science.gov (United States)

    Bequele, Assefa; Boyden, Jo

    1988-01-01

    Examines the types of employment children are most frequently engaged in, the risks involved, earnings, relationship between work and school, and the constraints on the exercise of their rights. Discusses initiatives underway to protect child workers, meet their needs, and formulate government policy. (JOW)

  4. Latin American universities and the third mission : trends, challenges, and policy options

    OpenAIRE

    Thorn, Kristian; Soo, Maarja

    2006-01-01

    Universities in Latin America are increasingly considered instruments of social and economic development and face rising expectations in regard to supplying relevant skills, undertaking applied research, and engaging in commercial activity. The paper discusses trends and challenges within Latin American universities, as well as policy options available for strengthening their contributions to social and economic development. The so-called third mission of universities is often equated with kn...

  5. The Growth of China and India: Implications and Policy Reform Options for Malaysia

    OpenAIRE

    Ianchovichina, Elena; Ivanic, Maros; Martin, Will

    2010-01-01

    This study explores the trade-related impacts of rapid growth of China and India on the Malaysian economy and evaluates policy options to better position Malaysia to take advantage of these changes. Higher growth in China and India is likely to raise Malaysia's national income and to expand Malaysia's natural resource and agricultural exports, while putting downward pressure on exports from some manufacturing and service sectors. Increases in the quality and variety of exports from China and ...

  6. Taking action against ocean acidification: a review of management and policy options.

    Science.gov (United States)

    Billé, Raphaël; Kelly, Ryan; Biastoch, Arne; Harrould-Kolieb, Ellycia; Herr, Dorothée; Joos, Fortunat; Kroeker, Kristy; Laffoley, Dan; Oschlies, Andreas; Gattuso, Jean-Pierre

    2013-10-01

    Ocean acidification has emerged over the last two decades as one of the largest threats to marine organisms and ecosystems. However, most research efforts on ocean acidification have so far neglected management and related policy issues to focus instead on understanding its ecological and biogeochemical implications. This shortfall is addressed here with a systematic, international and critical review of management and policy options. In particular, we investigate the assumption that fighting acidification is mainly, but not only, about reducing CO2 emissions, and explore the leeway that this emerging problem may open in old environmental issues. We review nine types of management responses, initially grouped under four categories: preventing ocean acidification; strengthening ecosystem resilience; adapting human activities; and repairing damages. Connecting and comparing options leads to classifying them, in a qualitative way, according to their potential and feasibility. While reducing CO2 emissions is confirmed as the key action that must be taken against acidification, some of the other options appear to have the potential to buy time, e.g. by relieving the pressure of other stressors, and help marine life face unavoidable acidification. Although the existing legal basis to take action shows few gaps, policy challenges are significant: tackling them will mean succeeding in various areas of environmental management where we failed to a large extent so far.

  7. Securing water for wetland conservation: a comparative analysis of policy options to protect a national nature reserve in China.

    Science.gov (United States)

    Wu, Jian; Wu, Junjie; Wang, Xiaoxia; Zhong, Ma

    2012-02-01

    This study evaluates four policy options to secure the water supply needed for wetland conservation in Qixinghe--a national wetland nature reserve in China--using four criteria: cost effectiveness, probability of success in achieving the water-saving goal, political feasibility, and farmer acceptance. This multi-criteria analysis framework reveals the ecological, economic, and socio-political trade-offs for policymakers when choosing among the four policy options. Results suggest that upgrading irrigation infrastructure in the area surrounding the wetland (Option I) is the most politically feasible option, but it is the second best option in terms of cost effectiveness. Constructing a dam to store and control floodwater (Option II) is the most reliable for achieving the water-saving goal. It is also the farmers' most favored strategy. But this option is the least cost effective and receives little support from local governments. Promoting farmers' adoption of water-saving practices (Option III) is the most cost effective, but it is less reliable for achieving the water-saving goal than Options I or II. Converting paddy crops to dry-land crops (Option IV) is politically infeasible and least reliable for achieving the water-saving goal. The overall ranking of the four options is determined using the policymakers' revealed weights on the four criteria. Option I is ranked first, followed by Options II, III, and IV.

  8. The Health Equity and Effectiveness of Policy Options to Reduce Dietary Salt Intake in England: Policy Forecast.

    Directory of Open Access Journals (Sweden)

    Duncan O S Gillespie

    Full Text Available Public health action to reduce dietary salt intake has driven substantial reductions in coronary heart disease (CHD over the past decade, but avoidable socio-economic differentials remain. We therefore forecast how further intervention to reduce dietary salt intake might affect the overall level and inequality of CHD mortality.We considered English adults, with socio-economic circumstances (SEC stratified by quintiles of the Index of Multiple Deprivation. We used IMPACTSEC, a validated CHD policy model, to link policy implementation to salt intake, systolic blood pressure and CHD mortality. We forecast the effects of mandatory and voluntary product reformulation, nutrition labelling and social marketing (e.g., health promotion, education. To inform our forecasts, we elicited experts' predictions on further policy implementation up to 2020. We then modelled the effects on CHD mortality up to 2025 and simultaneously assessed the socio-economic differentials of effect.Mandatory reformulation might prevent or postpone 4,500 (2,900-6,100 CHD deaths in total, with the effect greater by 500 (300-700 deaths or 85% in the most deprived than in the most affluent. Further voluntary reformulation was predicted to be less effective and inequality-reducing, preventing or postponing 1,500 (200-5,000 CHD deaths in total, with the effect greater by 100 (-100-600 deaths or 49% in the most deprived than in the most affluent. Further social marketing and improvements to labelling might each prevent or postpone 400-500 CHD deaths, but minimally affect inequality.Mandatory engagement with industry to limit salt in processed-foods appears a promising and inequality-reducing option. For other policy options, our expert-driven forecast warns that future policy implementation might reach more deprived individuals less well, limiting inequality reduction. We therefore encourage planners to prioritise equity.

  9. Analysis of China's Overheated Economy and Macroeconomic Policy Options

    Institute of Scientific and Technical Information of China (English)

    KeshaGuo

    2004-01-01

    Based on macroeconomic analysis since 2003, this article holds mat a trena towaras overheating has surfaced in China's economy. China's rapid economic expansion has affected the quality of its growth, with rising material and energy consumption and imbalanced economic structure as the main manifestations. Regarding macroeconomic policy options in 2004, decision-makers should shift the policy focus from control of deflation to prevention of inflation; the pace of economic growth should be properly set; a balance between consumption and investment should be strengthened by controlling excessive expansion of investment, and industrial restructuring should be conducted in a coordinated manner on the basis of properly controlling the overly rapid indastrial growth; policies should be continued to boost exports and sustainable growth of foreign investment; and more efforts should be made to accelerate the change in the mode of economic growth.

  10. The feasibility of multisectoral policy options aimed at reducing trans fats and encouraging its replacement with healthier oils in India.

    Science.gov (United States)

    Downs, Shauna M; Thow, Anne-Marie; Ghosh-Jerath, Suparna; Leeder, Stephen R

    2015-05-01

    The World Health Organization recommends replacement of trans fat with polyunsaturated fat to reduce cardiovascular disease risk. Although several high-income countries have been successful in reducing trans fat in the food supply, low- and middle-income countries such as India may face additional contextual challenges such as the large informal sector, lack of consumer awareness, less enforcement capacity and low availability and affordability of healthier unsaturated fats. The objective of this study was to examine the feasibility and acceptability of multisectoral policy options aimed at supporting trans fat reduction and its replacement with polyunsaturated fats in India. Multisectoral policy options examined in this study were identified using food supply chain analysis. Semi-structured interviews (n = 17) were conducted with key informants from agriculture, trade, finance, retail, industry, food standards, non-governmental organizations and the health professions to gain their views on the feasibility and acceptability of the policy options. Purposive sampling was used to identify key informants. Data were coded and organized based on key themes. There was support for policies aimed at improving the quality of seeds, supporting farmer co-operatives and developing affordable farming equipment suited to smallholders to improve the production of healthier oils. Increasing the role of the private sector to improve links among producers, processors and retailers may help to streamline the fats supply chain in India. Blending healthier oils with oils high in saturated fat, which are currently readily available, could help to improve the quality of fat in the short term. Improving consumer awareness through mass media campaigns and improved labelling may help increase consumer demand for healthier products. Reorienting agricultural policies to support production of healthier oils will help increase their uptake by industry. Policy coherence across sectors will be

  11. Preferences for Policy Options for Deceased Organ Donation for Transplantation: A Discrete Choice Experiment.

    Science.gov (United States)

    Howard, Kirsten; Jan, Stephen; Rose, John M; Wong, Germaine; Craig, Jonathan C; Irving, Michelle; Tong, Allison; Chadban, Steven; Allen, Richard D; Cass, Alan

    2016-05-01

    Despite broad public support for organ donation, there is a chronic shortage of deceased donor organs. We sought to identify community preferences for features of organ donation policies. A discrete choice study was conducted using an online panel of Australian community respondents older than 18 years. Respondents were presented with scenarios comparing a "new" policy to the current policy. Tradeoffs between 8 policy aspects were quantified using mixed logit and latent class models: registration system, extent of donor family involvement, ease of registration, frequency of confirmation of intent, direct payment, and funeral expense reimbursement, priority for donor's family, and formal recognition of donation. There were 2005 respondents (mean, 44.6 years). We found a strong preference for a new policy. Overall, respondents favored a policy that included: some involvement of the donor's family in the final decision, simple registration processes, less frequent reconfirmation of donation intent, direct payment or funeral expense reimbursement, and formal recognition of donation. However, there was significant preference heterogeneity across respondents, with various respondent groups valuing policy mechanisms differently. Respondents who viewed policy change negatively were also those who would be unlikely to be organ donors anyway, because they tended to hold negative views toward organ donation. Our results suggest that the Australian community are open to alternative organ donation policies including changes to: registration systems, family involvement, and financial and nonfinancial mechanisms. Future policy discussions should not be limited by preconceived notions of what is acceptable to the community, rather informed by actual community values and preferences.

  12. Policy and Current Account Determination under Floating Exchange Rates

    OpenAIRE

    Hans Genberg; Alexander K. Swoboda

    1989-01-01

    The determinants of current account imbalances under floating exchange rates are analyzed. The analysis provides a framework within which the sources of, and the remedies for, the current account imbalances between the United States, Japan, and the Federal Republic of Germany can be discussed. The effects of various government policies are emphasized, in particular the differences between expenditure-changing and expenditure-switching policies. Short-run and long-run considerations are invest...

  13. Milk marketing policy options for the dairy industry in New England.

    Science.gov (United States)

    Doyon, M; Criner, G; Bragg, L A

    2008-03-01

    New England dairy farmers are under intense price pressure resulting from important growth in milk production from lower cost of production Southwest states as well as by retailers' market power. Agricultural officials and legislative bodies in New England and in other Northeast US states are aware of these pressures and have been reacting with emergency dairy farm aid, following a very low 2006 milk price, and with state legislations in an attempt to address perceived excess retailing margins for fluid milk. In this paper, we suggest that a sigmoid demand relationship exists for fluid milk. This demand relationship would explain fluid milk asymmetric price transmission, high-low pricing, and the creation of a large retailing margin (chain surplus) often observed for fluid milk. It is also argued that a sigmoid demand relationship offers an opportunity for state legislators to help Northeast dairy farmers capturing a larger share of the dollar of the consumers through various policy options. Therefore, 5 milk market channel regulatory mechanisms (status quo, price gouging, supply control, fair share policy, and chain surplus return) are discussed and compared. The supply control mechanism was found the most effective at redistributing the chain surplus, associated with the sigmoid demand relationship for fluid milk, to dairy farmers. However, this option is unlikely to be politically acceptable in the United States. Second-best options for increasing dairy farmers' share of the consumers' dollar are the fair price policy and the chain surplus return. The former mechanism would distribute the chain surplus between retailers, processors, and farmers, whereas the latter would distribute it between consumers, retailers, and farmers. Remaining mechanisms would either transfer the chain surplus to retailers (status quo) or to consumers (price gouging).

  14. Alleviating water scarcity in Northern China: balancing options and policies among Chinese decision-makers.

    Science.gov (United States)

    Lasserre, F

    2003-01-01

    Water scarcity is mostly a man-made problem that increasingly affects people's lives and questions economic output in Northern China. Policy options addressing the serious water shortages in the region include conservation and water management reform, which is unpopular; grain imports and the downsizing of agriculture; derivation of Yangze water; derivation of the Amur and other international rivers. All solutions present major difficulties, whether domestic or international, for the Chinese authorities. While major decisions have not yet been taken, evidence shows major works such as water transfers from the Yangze or water pricing are not only unavoidable, but will not be enough to meet the growing demand for water in the region.

  15. DETERMINANTS OF CURRENT ACCOUNT DEFICIT AND ECONOMY POLICIES PRACTICES FOR CURRENT ACCOUNT DEFICIT IN TURKISH ECONOMY

    Directory of Open Access Journals (Sweden)

    Veysel Karagol

    2017-03-01

    Full Text Available In last years with the impact of rapid globalization and financiallisation current account deficit became a major problem for Turkish economy. Hence, many studies have been conducted foreseeing for policy recommendations and precautions against the current deficit. In this study, by considering determinants of current account deficit and implemented policies, it is intended to provide policy recommendations for closing the deficit. As part of this goal, the determinants of current account deficit and impacts of the determinantsa re discussed. Also, by mentioning monetary and fiscal policies during the period 2003-2015 overall assessment of the policies and a set of policiy recommendations for the next periods were presented. The most important result achieved by the study is applying discussed structural reforms in able to have quick progress in dealing with the current account deficit would have a great effect.

  16. The effectiveness of recycling policy options: waste diversion or just diversions?

    Science.gov (United States)

    Mueller, William

    2013-03-01

    Recycling is becoming ever more important as waste generation rates increase globally. Policy-makers must decide which recycling practices to implement from the host of options at their disposal to best divert waste from landfill. This study strived to determine the most important characteristics in recycling programs that were associated with higher material recovery rates, including bag limits, user pay programs, the number of materials collected, curbside collection frequency, promotion and education (P&E) activities, Best Practice principles, and the type of recycling collection stream. Data collected from 223 recycling programs in Ontario during 2005-2010 were used to perform multiple regression analyses. The findings of this study suggest that attributes of convenience are more important to encourage recycling than those that penalize disposal, thus providing important implications for waste policy-makers, both in Ontario and in other jurisdictions.

  17. ACCOUNTING POLICIES AND OPTIONS ON THE RECOGNITION, MEASUREMENT AND DERECOGNITION OF INVENTORIES IN PUBLIC SECTOR ENTITIES

    Directory of Open Access Journals (Sweden)

    CRISTINA OTILIA ȚENOVICI

    2012-11-01

    Full Text Available International accounting harmonization focuses on improving and reducing the differences between national accounting regulations concerning accounting rules and principles, of general interest, likely to determine the comparability of information in financial statements of institutions, respectively to reduce differences among accounting regulations of different countries. The reference system for drafting accounting policies allows alternatives for accounting registration and assessment, respectively different methods of assessing the patrimony, the result and financial position. The choice of an accounting option is determined by the need to provide a clear financial image on the position and performance of the institution. Thus, for stock assessment they choose the accounting policy likely to provide relevant, reliable, neutral, prudent and complete information in all significant respects by means of with the financial statements.

  18. Evaluation of policy options to reform the EU Emissions Trading System. Effects on carbon price, emissions and the economy

    Energy Technology Data Exchange (ETDEWEB)

    Verdonk, M.; Brink, C.; Vollebergh, H.; Roelfsema, M.

    2013-04-15

    The EU Emissions Trading System (EU ETS) is a key instrument of EU climate policy, providing a clear reduction pathway for CO2 emissions. The current carbon price (of about 3 euros per tonne of CO2, April 2013) is much lower than previously expected (which was around 30 euros) and is likely to remain low for a long time. This fuels doubts about whether the ETS will remain a key policy instrument in the long term. Such doubts also increase investment uncertainty, which is likely to have a negative impact on further investments in low-carbon technologies needed for a low-carbon economy in 2050. In November 2012, the European Commission put forward six options for a more structural reform of the EU ETS. The proposed options vary from reducing the cap and expanding the ETS to include other sectors, to strengthening the ETS by measures directly affecting allowance prices. The Dutch Ministry of Infrastructure and the Environment (IenM) asked the PBL Netherlands Environmental Assessment Agency to assess the impact of these options. Four categories of options for reforming the ETS were evaluated: (1) reducing the supply of emission allowances; (2) expanding the ETS by including other sectors; (3) a minimum price for auctioned allowances; and (4) combining ETS with a carbon tax. Recently, the European Parliament voted against the European Commission's proposal to temporarily set aside emission allowances. In an earlier assessment of this proposal, PBL concluded that the impact of this backloading proposal on CO2 prices is likely to be limited, because the total amount of allowances up to 2020 would remain unchanged. All options analysed would reduce emissions and cause the emission price to increase. A minimum price on carbon, however, would provide the best opportunity to make the ETS more robust against unforeseen events, such as a further deterioration of the economy. Such a minimum price would result in more emission reductions if abatement proves to be cheaper

  19. Analysis of federal policy options for improving US lighting energy efficiency: Commercial and residential buildings

    Energy Technology Data Exchange (ETDEWEB)

    Atkinson, B.A.; McMahon, J.E.; Mills, E.; Chan, P.; Chan, T.W.; Eto, J.H.; Jennings, J.D.; Koomey, J.G.; Lo, K.W.; Lecar, M.; Price, L.; Rubinstein, F.; Sezgen, O.; Wenzel, T.

    1992-12-01

    The US Department of Energy (DOE) has recognized the opportunity to achieve energy, economic, and environmental benefits by promoting energy-efficient lighting through federal policies, including lighting standards, financial incentives, and information programs. To assist in this process, the Office of Conservation and Renewable Energy's Office of Codes and Standards invited Lawrence Berkeley Laboratory to assess prospective national impacts for a variety of policy options. Some progress has already been made in developing lighting policies at both the federal and state levels. The US DOE's Office of Building Technologies has evaluated lighting efficiency incentives as part of its analysis for the National Energy Strategy. Fluorescent and incandescent lamp standards are included in the national Energy Policy Act of 1992 (P.L. 102-486, October 24, 1992). A few states have analyzed or implemented lamp and luminaire standards. Many policy-related issues merit further investigation. For example, there is considerable debate over issues such as mandatory or voluntary standards versus component labeling and other education-oriented strategies. Several different technologies are involved that interact with each other-lamps (incandescent, compact fluorescent, and HID), ballasts (for fluorescent and HID lamps), and fixtures with reflectors and lenses. Control systems and operation patterns must also be considered (timers, automated dimming, or occupancy sensors). Lighting applications are diverse, ranging from offices, restaurants, hallways, hospital operating rooms, to exterior lights. Lighting energy use influences heating and cooling requirements in buildings. Successful lighting system design must also address interactions between architectural design elements and daylighting availability. Proper system installation and ongoing operation and maintenance are crucial. The economic aspects of the preceding points must also be considered for policy making.

  20. Analysis of federal policy options for improving US lighting energy efficiency: Commercial and residential buildings

    Energy Technology Data Exchange (ETDEWEB)

    Atkinson, B.A.; McMahon, J.E.; Mills, E.; Chan, P.; Chan, T.W.; Eto, J.H.; Jennings, J.D.; Koomey, J.G.; Lo, K.W.; Lecar, M.; Price, L.; Rubinstein, F.; Sezgen, O.; Wenzel, T.

    1992-12-01

    The US Department of Energy (DOE) has recognized the opportunity to achieve energy, economic, and environmental benefits by promoting energy-efficient lighting through federal policies, including lighting standards, financial incentives, and information programs. To assist in this process, the Office of Conservation and Renewable Energy`s Office of Codes and Standards invited Lawrence Berkeley Laboratory to assess prospective national impacts for a variety of policy options. Some progress has already been made in developing lighting policies at both the federal and state levels. The US DOE`s Office of Building Technologies has evaluated lighting efficiency incentives as part of its analysis for the National Energy Strategy. Fluorescent and incandescent lamp standards are included in the national Energy Policy Act of 1992 (P.L. 102-486, October 24, 1992). A few states have analyzed or implemented lamp and luminaire standards. Many policy-related issues merit further investigation. For example, there is considerable debate over issues such as mandatory or voluntary standards versus component labeling and other education-oriented strategies. Several different technologies are involved that interact with each other-lamps (incandescent, compact fluorescent, and HID), ballasts (for fluorescent and HID lamps), and fixtures with reflectors and lenses. Control systems and operation patterns must also be considered (timers, automated dimming, or occupancy sensors). Lighting applications are diverse, ranging from offices, restaurants, hallways, hospital operating rooms, to exterior lights. Lighting energy use influences heating and cooling requirements in buildings. Successful lighting system design must also address interactions between architectural design elements and daylighting availability. Proper system installation and ongoing operation and maintenance are crucial. The economic aspects of the preceding points must also be considered for policy making.

  1. Making Homes Part of the Climate Solution: Policy Options To Promote Energy Efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Dr. Marilyn Ann [Georgia Institute of Technology; Chandler, Jess [Georgia Institute of Technology; Lapsa, Melissa Voss [ORNL; Ally, Moonis [Oak Ridge National Laboratory (ORNL)

    2009-06-01

    In the area of energy efficiency, advanced technologies combined with best practices appear to afford not only large, but also cost-effective options to conserve energy and reduce greenhouse gas emissions (McKinsey & Company, 2007). In practice, however, the realization of this potential has often proven difficult. Progress appears to require large numbers of individuals to act knowledgeably, and each individual must often act with enabling assistance from others. Even when consumer education is effective and social norms are supportive, the actions of individuals and businesses can be impeded by a broad range of barriers, many of which are non-technical in nature. Title XVI of the Energy Policy Act of 2005 included a mandate to examine barriers to progress and make recommendations in this regard. A detailed report on barriers as well as the National strategy for overcoming barriers met this requirement (Brown et al, 2008; CCCSTI, 2009). Following up on this mandate, the U.S. Climate Change Technology Program (CCTP) chose to focus next on the development of policy options to improve energy efficiency in residential buildings, with supporting analysis of pros and cons, informed in part by behavioral research. While this work is sponsored by CCTP, it has been undertaken in coordination with DOE's Building Technologies Program and Office of Electricity Delivery and Energy Reliability.

  2. Current and emerging management options for patients with Morquio A syndrome.

    Science.gov (United States)

    Algahim, Mohamed F; Almassi, G Hossein

    2013-01-01

    Morquio A syndrome is a lysosomal storage disease associated with mucopolysaccharidosis. It is caused by a deficiency of the lysosomal enzyme, N-acetylgalactosamine-6-sulfate sulfatase, which leads to accumulation of keratan sulfate and condroitin-6 sulfate in multiple organs. Patients present with multisystemic complications involving the musculoskeletal, respiratory, cardiovascular, and digestive systems. Presently, there is no definitive cure, and current management options are palliative. Enzyme replacement therapy and hematopoietic stem cell therapy have been proven effective in certain lysosomal storage diseases, and current investigations are underway to evaluate the effectiveness of these therapies and others for the treatment of Morquio A syndrome. This review discusses the current and emerging treatment options for Morquio A syndrome, citing examples of the treatment of other mucopolysaccharidoses.

  3. Current and emerging management options for patients with Morquio A syndrome

    Directory of Open Access Journals (Sweden)

    Algahim MF

    2013-02-01

    Full Text Available Mohamed F Algahim, G Hossein AlmassiDivision of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI, USAAbstract: Morquio A syndrome is a lysosomal storage disease associated with mucopolysaccharidosis. It is caused by a deficiency of the lysosomal enzyme, N-acetylgalactosamine-6-sulfate sulfatase, which leads to accumulation of keratan sulfate and condroitin-6 sulfate in multiple organs. Patients present with multisystemic complications involving the musculoskeletal, respiratory, cardiovascular, and digestive systems. Presently, there is no definitive cure, and current management options are palliative. Enzyme replacement therapy and hematopoietic stem cell therapy have been proven effective in certain lysosomal storage diseases, and current investigations are underway to evaluate the effectiveness of these therapies and others for the treatment of Morquio A syndrome. This review discusses the current and emerging treatment options for Morquio A syndrome, citing examples of the treatment of other mucopolysaccharidoses.Keywords: lysosomal, storage disease, mucopolysaccharidosis

  4. Family Policy Options for the Welfare of China's Children in the Future

    Institute of Scientific and Technical Information of China (English)

    ChengHaijun,; ZhuShida; DavidKelly

    2004-01-01

    China's current child welfare policies principally stress the importance of family care. The state will not intervene unless there is harm to the child. Owing to economic and human resource limitations, govemment child welfare work is mainly remedial: rendering assistance to orphaned,

  5. Managing plutonium in Britain. Current options[Mixed oxide nuclear fuels; Nuclear weapons

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    This is the report of a two day meeting to discuss issues arising from the reprocessing of plutonium and production of mixed oxide nuclear fuels in Britain. It was held at Charney Manor, near Oxford, on June 25 and 26, 1998, and was attended by 35 participants, including government officials, scientists, policy analysts, representatives of interested NGO's, journalists, a Member of Parliament, and visiting representatives from the US and Irish governments. The topic of managing plutonium has been a consistent thread within ORG's work, and was the subject of one of our previous reports, CDR 12. This particular seminar arose out of discussions earlier in the year between Dr. Frank Barnaby and the Rt. Hon. Michael Meacher MP, Minister for the Environment. With important decisions about the management of plutonium in Britain pending, ORG undertook to hold a seminar at which all aspects of the subject could be aired. A number of on-going events formed the background to this initiative. The first was British Nuclear Fuels' [BNFL] application to the Environment Agency to commission a mixed oxide fuel [MOX] plant at Sellafield. The second was BNFL's application to vary radioactive discharge limits at Sellafield. Thirdly, a House of Lords Select Committee was in process of taking evidence, on the disposal of radioactive waste. Fourthly, the Royal Society, in a recent report entitled Management of Separated Plutonium, recommended that 'the Government should commission a comprehensive review... of the options for the management of plutonium'. Four formal presentations were made to the meeting, on the subjects of Britain's plutonium policy, commercial prospects for plutonium use, problems of plutonium accountancy, and the danger of nuclear terrorism, by experts from outside the nuclear industry. It was hoped that the industry's viewpoint would also be heard, and BNFL were invited to present a paper, but declined on the grounds that they

  6. THE INNOVATIVE POLICY OPTIONS FOR COASTAL FISHERIES ECONOMIC DEVELOPMENT: A CASE OF KWANDANG BAY COASTAL ECOSYSTEM

    Directory of Open Access Journals (Sweden)

    Noel Taylor Moore

    2017-07-01

    Full Text Available Socio-environmental problems, such as climate change, pollution and habitat destruction, present serious challenges for fisheries economic development. The integration of interventions or investments within a coastal marine ecosystem, a defined spatial area, is considered important in the economic development of local communities leading to the planned outcomes of livelihoods, food security and conservation The coastal marine ecosystem, is the provider of products and services to the local economy adjacent to the ecosystem where the benefit flows, within that area, are interconnected. The roles of science, technology and innovation (STI are an integral part of these multi-dimensional interventions. Hence the need for an integrated approach for these interventions by government and/or through donor funded projects to enhance economic development of coastal communities. The policy framework proposed is therefore an STI perspective of the links between these intervention and investment options, based on a ‘fisheries economic development Hub’ (Hub and discussed using the multi-level perspective (MLP. The policy innovation proposal suggests an implementation strategy of a pilot project and analyses the selection and implications of a potential Indonesian site for the application of the Hub. This paper aims to introduce the MLP into the framework of coastal community-based fisheries economic development.   Key words: policy innovation. coastal marine ecosystem, fisheries economic development Hub, value chains, multi-level perspective (MLP

  7. Exploring Policy Options to Stop the Loss of Wetlands on Prairie Landscapes

    Science.gov (United States)

    Serran, J.; Creed, I. F.

    2013-12-01

    Wetlands from the prairie pothole region of North America have been disappearing at rapid rates over the past century. Within Canada, the issue of wetland loss is compounded by the lack of high resolution wetland inventories, the lack of information on rates of wetland loss, and the absence of wetland policies to further protect against loss. In Alberta, the situation is particularly problematic as increasing development pressures continue to place wetlands at risk. The 'no net loss' of wetlands policy established in 1993 has been ineffective, as wetland loss has continued, leaving Albertans searching for alternative policy options. An alternative policy option is to shift focus from wetland area to wetland function. We present a wetland function assessment system founded on ecological and hydrological processes for estimating wetland functions, including biodiversity, flood control, and pollution reduction, for a regional watershed in Alberta. First, we establish wetland loss rates using inventory time series from 1960 to present; wetland loss estimates can be derived from a break in slope in the area-frequency relationship. Second, we create a high-resolution wetland inventory using a novel approach that fuses LiDAR data (probability of wetland) with aerial photographs (to distinguish open water and the surrounding wet meadow zone). Third, using this wetland inventory, we identify indicators of wetland function using GIS and remote sensing data and technologies for application at regional watershed scales. Biodiversity indicators include a wetland's condition, ability to provide habitat, and potential for high ecological diversity. Flood control indicators include a wetland's ability to store water, connect to surface drainage network, and desynchronize flood waves throughout the landscape. Pollution control indicators include a wetland's contributing source area of nutrients, mechanisms that transport nutrients to the wetland, and mechanisms that retain

  8. Avoiding the Tragedy of the Commons in Health Care: Policy Options for Covering High-Cost Cures.

    Science.gov (United States)

    Mattke, Soeren; Liu, Hangsheng; Hoch, Emily; Mulcahy, Andrew W

    2017-01-01

    In this article, Mattke and his colleagues discuss the risk that strategic behavior by health insurers could unravel the market for curative therapies for chronic diseases. Because the cost of these cures is front-loaded but the benefits accrue over time, insurers might attempt to delay treatment or avoid patients who require it, in the hope that they might change insurers. The authors discuss policy options to remedy this potential free-rider problem through alignment of incentives at the patient level, coordination among payers, and government intervention. They present a framework to analyze policy options and real-world case studies. While implementing those policy options is far from easy, stakeholders need to collaborate in order to establish equitable mechanisms that fairly distribute the cost and benefits of high-cost cures.

  9. Behavioural Climate Change Mitigation Options and Their Appropriate Inclusion in Quantitative Longer Term Policy Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Faber, J.; Schroten, A.; Bles, M.; Sevenster, M.; Markowska, A.; Smit, M. [CE Delft, Delft (Netherlands); Rohde, C.; Duetschke, E.; Koehler, J.; Gigli, M. [Fraunhofer Institute for Systems and Innovation Research ISI, Karlsruhe (Germany); Zimmermann, K.; Soboh, R.; Van ' t Riet, J. [Landbouw Economisch Instituut LEI, Wageningen (Netherlands)

    2012-01-15

    Changes in consumer behaviour can lead to major reductions in greenhouse gas emissions in the European Union, particularly in the areas of transport, housing and food. Behavioural changes can complement technological changes and can allow emission reduction targets to be achieved more cost-effectively overall. The study identifies 36 options for behavioural change that would cut greenhouse gas emissions. Of these, 11 particularly relevant options have been studied in detail. They include shifting to a more healthy and balanced diet, eating less meat and dairy products, buying and using a smaller car or an electric car, teleworking, adjusting room temperature and optimising ventilation. For each of the behavioural changes studied in depth, emission reduction potentials have been quantified for 2020, 2030 and 2050. The study identifies barriers to implementing the changes, and quantifies the likely effects of policy packages which could overcome these barriers. The results show that the behavioural changes that could take place simultaneously have the potential to save emissions totalling up to about 600 million tonnes of CO2-equivalent a year in 2020. This is about one-quarter of the projected annual emissions from sectors not covered by the EU emissions trading system. The savings potential is particularly high in the area of food.

  10. [Integration, exclusion and solidarity in the current social policy debate].

    Science.gov (United States)

    Magalhães, R

    2001-01-01

    The current global trend involving transformation of work and the crisis in large government economic development and intervention projects in the market are raising new challenges for social policies to combat poverty. This study reconstitutes and analyzes the tensions, paradoxes, and main consequences of this process, focusing on problems concerned with combining solidarity strategies and public welfare systems.

  11. [Options for a future-oriented innovation policy in the medical devices industry].

    Science.gov (United States)

    Nusser, Michael; Lindner, Ralf

    2010-01-01

    From an innovation systems perspective the performance of the German medical devices industry, future challenges and barriers to innovation are assessed. Current performance indicators (e.g., R&D intensity, export growth rates) paint a favourable picture. Nonetheless, a number of innovation barriers are identified: in particular, insufficient network integration of small and medium-sized enterprises (SMEs) and ineffective policy coordination. Finally, recommendations addressing identified future challenges and innovation barriers are developed.

  12. NAFTA as an agricultural "policy option" for Mexico : a case study within a two-level framework

    OpenAIRE

    Røssaak, Camilla

    1996-01-01

    NAFTA AS AN AGRICULTURAL 'POLICY OPTION' FOR MEXICO: A CASE STUDY WITHIN A TWO- LEVEL FRAMEWORK The main focus of the thesis was the agricultural negotiation process between Mexico and the United States within the NAFTA process. I wanted to investigate to what extent this process led to changes in Mexican agricultural policy. Furthermore I wanted to find out whose interests were taken into consideration when Mexico negotiated agriculture in NAFTA. If so, was this done at the expense o...

  13. VAMOS: The verification and monitoring options study: Current research options for in-situ monitoring and verification of contaminant remediation and containment within the vadose zone

    Energy Technology Data Exchange (ETDEWEB)

    Betsill, J.D. [Sandia National Labs., Albuquerque, NM (United States); Gruebel, R.D. [Tech Reps., Inc., Albuquerque, NM (United States)

    1995-09-01

    The Verification and Monitoring Options Study Project (VAMOS) was established to identify high-priority options for future vadose-zone environmental research in the areas of in-situ remediation monitoring, post-closure monitoring, and containment emplacement and verification monitoring. VAMOS examined projected needs not currently being met with applied technology in order to develop viable monitoring and verification research options. The study emphasized a compatible systems approach to reinforce the need for utilizing compatible components to provide user friendly site monitoring systems. To identify the needs and research options related to vadose-zone environmental monitoring and verification, a literature search and expert panel forums were conducted. The search included present drivers for environmental monitoring technology, technology applications, and research efforts. The forums included scientific, academic, industry, and regulatory environmental professionals as well as end users of environmental technology. The experts evaluated current and future monitoring and verification needs, methods for meeting these needs, and viable research options and directions. A variety of high-priority technology development, user facility, and technology guidance research options were developed and presented as an outcome of the literature search and expert panel forums.

  14. How do new innovation paradigms challenge current innovation policy perspectives

    DEFF Research Database (Denmark)

    Knudsen, Mette Præst; Tanev, Stoyan; Bisgaard, Tanja

    2012-01-01

    multiple actors by managing knowledge sharing processes across entire value networks. The chapter provides a brief description and comparison of these new innovation paradigms and discusses the challenges that these paradigms imply for existing innovation policies. The innovation policy recommendations......Successful firms today are forced to deal with new competitive realities by being globally present, innovatively resourceful and internationally competitive on multiple markets across the world. The new competitive realities challenge firms to open their innovation processes by adopting new...... innovation paradigms such as user-driven innovation, open innovation and value co-creation. The user-driven and open innovation paradigms have already become the subject of extensive research and are currently discussed in terms of their potential implications for policy development. The value co...

  15. Managing vulnerability to drought and enhancing livelihood resilience in sub-Saharan Africa: Technological, institutional and policy options

    Directory of Open Access Journals (Sweden)

    Bekele Shiferaw

    2014-06-01

    Full Text Available Agriculture and the economies of Sub-Saharan Africa (SSA are highly sensitive to climatic variability. Drought, in particular, represents one of the most important natural factors contributing to malnutrition and famine in many parts of the region. The overall impact of drought on a given country/region and its ability to recover from the resulting social, economic and environmental impacts depends on several factors. The economic, social and environmental impacts of drought are huge in SSA and the national costs and losses incurred threaten to undermine the wider economic and development gains made in the last few decades in the region. There is an urgent need to reduce the vulnerability of countries to climate variability and to the threats posed by climate change. This paper attempts to highlight the challenges of drought in SSA and reviews the current drought risk management strategies, especially the promising technological and policy options for managing drought risks to protect livelihoods and reduce vulnerability. The review suggests the possibilities of several ex ante and ex post drought management strategies in SSA although their effectiveness depends on agro-climatic and socio-economic conditions. Existing technological, policy and institutional risk management measures need to be strengthened and integrated to manage drought ex ante and to minimize the ex post negative effects for vulnerable households and regions. A proactive approach that combines promising technological, institutional and policy solutions to manage the risks within vulnerable communities implemented by institutions operating at different levels (community, sub-national, and national is considered to be the way forward for managing drought and climate variability.

  16. The Baltic policy of Germany and current international relations

    Directory of Open Access Journals (Sweden)

    Salikov Aleksey

    2016-03-01

    Full Text Available This article analyses the Baltic policy of united Germany from the 1990s until today. The authors set out to identify the significance of German-Baltic relations and the role of the Eastern policy in Russian-German relations. The method of dynamic comparison between the political and economic narrative in intergovernmental relations makes it possible to identify distinctive features of Germany’s Baltic policy in the context of current international relations. In particular, it is noted that Germany was most active in the Baltic region in the 1990s, when the country was establishing political, economic, and cultural ties with the new independent states. In the second half of the 1990s, Germany’s foreign policy became less intense. After the accession of Lithuania, Latvia, and Estonia to the EU and NATO in 2004, certain disagreements started to arise between Germany and the Baltics. It explains the lukewarm relations between them. The Ukraine events brought about a change in Germany’s regional policy. Despite Russia remaining one of the key economic and political counteractors, Germany, being a partner of the Baltics in the EU and NATO, cannot adopt a neutral position in the conflict of interests between the Baltics and Russia.

  17. Status of the world's remaining closed forests: An assessment using satellite data and policy options

    Science.gov (United States)

    Singh, A.; Shi, H.; Foresman, T.; Fosnight, E.A.

    2001-01-01

    Historically, it appears that some of the WRCF have survived because i) they lack sufficient quantity of commercially valuable species; ii) they are located in remote or inaccessible areas; or iii) they have been protected as national parks and sanctuaries. Forests will be protected when people who are deciding the fate of forests conclude than the conservation of forests is more beneficial, e.g. generates higher incomes or has cultural or social values, than their clearance. If this is not the case, forests will continue to be cleared and converted. In the future, the WRCF may be protected only by focused attention. The future policy options may include strategies for strong protection measures, the raising of public awareness about the value of forests, and concerted actions for reducing pressure on forest lands by providing alternatives to forest exploitation to meet the growing demands of forest products. Many areas with low population densities offer an opportunity for conservation if appropriate steps are taken now by the national governments and international community. This opportunity must be founded upon the increased public and government awareness that forests have vast importance to the welfare of humans and ecosystems' services such as biodiversity, watershed protection, and carbon balance. Also paramount to this opportunity is the increased scientific understanding of forest dynamics and technical capability to install global observation and assessment systems. High-resolution satellite data such as Landsat 7 and other technologically advanced satellite programs will provide unprecedented monitoring options for governing authorities. Technological innovation can contribute to the way forests are protected. The use of satellite imagery for regular monitoring and Internet for information dissemination provide effective tools for raising worldwide awareness about the significance of forests and intrinsic value of nature.

  18. Using value of statistical life for the ex ante evaluation of transport policy options: a discussion based on ethical theory

    NARCIS (Netherlands)

    Van Wee, G.P.; Rietveld, P.

    2012-01-01

    This paper aims to discuss a number of questions that are highly important for the ex ante evaluation of the safety impacts of transport policy options, from the perspective of ethical theory: (1) Is it morally OK to express prevention on acceptance of fatalities or risks in monetary terms? (2) How

  19. Trends in Mexican gasoline consumption; Challenges and policy options for upgrading production

    Energy Technology Data Exchange (ETDEWEB)

    Morales-Moreno, I. (El Colegio de Mexico, Centro de Estudios Economicos (MX))

    1990-01-01

    Production and consumption of motor gasolines in Mexico confront many problems at present: the product is of low quality and highly pollutant, there is inefficiency in consumption, and the existence of technical and financial ''bottle-necks'' inhibit increases of output and supply. Currently, the oil monopoly --PEMEX-- has become a target of criticism by the Salinas de Gortari administration, whose new ''liberal'' policies aim at strengthening the activities and interests of private concerns. However, even though private investments were recently allowed in the production of several petrochemical products, upstream as well as downstream activities will ramain a monopoly of the state company. The main problems that Mexican gasolines are confronting and the new policies launched very recently by the Salinas government in order to solve the problem of production and quality are reviewed. (AB).

  20. Breast fibromatosis response to tamoxifen: dynamic MRI findings and review of the current treatment options.

    Science.gov (United States)

    Plaza, Michael J; Yepes, Monica

    2012-03-01

    Breast fibromatosis is a rare entity responsible for 0.2% of all solid breast tumors. It has been associated with scars, pregnancy, implants, and familial adenomatous polyposis. We present an interesting case of breast fibromatosis in a 29 year old woman which encroached upon her saline implant and subsequently filled its cavity once the implant was removed. The patient was put on tamoxifen therapy and at 14 month follow-up there was a significant decrease in the size of the mass. Dynamic MRI images are offered for review and current treatment options are discussed.

  1. Evaluation of supplier obligation policy options: Report for DTI and DEFRA

    Energy Technology Data Exchange (ETDEWEB)

    Radov, Daniel; Klevnas, Per; Nagler, David

    2007-05-23

    This report examines various policy design options for a future 'Supplier Obligation' to promote energy efficiency in the domestic sector. It examines possible reasons that low-cost energy efficiency measures have not been taken up to the extent predicted by simple models of household financial decision-making. Having characterised these 'barriers' to energy efficiency we review a range of policy designs that could be considered to reduce household CO{sub 2} emissions. We then evaluate these options against a range of criteria and suggest areas for further research. There is a substantial literature on the barriers to energy efficiency both within households and more generally across the economy. Based on this literature, w e have identified seven categories of 'barriers'. Briefly, these include: Basic financial barriers: These include the potentially higher (upfront) costs of energy efficient products and the interest rates available to households; Hidden costs: These include 'transaction costs' associated with finding reputable providers, time costs of disruption, and the costs of differences in quality of product or service - all of which may reduce the net benefit derived from efficiency measures. Lack of information: If households do not know their level of energy expenditure, how energy use can be reduced, by how much, or at what cost, they are unlikely to consider investing in energy efficiency. Risks and uncertainty: Uncertainty about future energy prices or period of tenure may deter households from investing, since they cannot be assured of future savings. In addition, households may be wary of the risk associated with new (or unfamiliar) products or services. Poorly aligned incentives: The most commonly cited barrier of this kind is the 'landlord-tenant split, whereby landlords under-invest in energy-efficiency because tenants pay energy bills, or tenants do not economise on energy because the landlord pays

  2. A real options approach to biotechnology Investment policy - the case of developing a Campylobacter vaccine to poultry

    DEFF Research Database (Denmark)

    Lund, Mogens; Jensen, Jørgen Dejgård

    2016-01-01

    in a cost-effective way. The development of a vaccine against Campylobacter jejuni in poultry is applied as a case study. Employing the real options methodology, the net present value of the vaccine R&D project becomes larger than a purely probabilistic expected present value throughout the different stages...... of the project – and the net present value becomes larger, when more types of real options are taken into consideration. The insight from the real options analysis reveals opportunities for new policies to promote the development of animal vaccines. One such approach might be to develop schemes combining stage......-by-stage optimized subsidies in the individual development stages, with proper account taken of investors'/developers' economic incentives to proceed, sell or cancel the project in the respective stages. Another way of using the real options approach to support the development of desirable animal vaccines could...

  3. The Sulu-Sulawesi Sea: environmental and socioeconomic status, future prognosis and ameliorative policy options.

    Science.gov (United States)

    DeVantier, Lyndon; Alcala, Angel; Wilkinson, Clive

    2004-02-01

    The Sulu-Sulawesi Sea, with neighboring Indonesian Seas and South China Sea, lies at the center of the world's tropical marine biodiversity. Encircled by 3 populous, developing nations, the Philippines, Indonesia and Malaysia, the Sea and its adjacent coastal and terrestrial ecosystems, supports ca. 33 million people, most with subsistence livelihoods heavily reliant on its renewable natural resources. These resources are being impacted severely by rapid population growth (> 2% yr-1, with expected doubling by 2035) and widespread poverty, coupled with increasing international market demand and rapid technological changes, compounded by inefficiencies in governance and a lack of awareness and/or acceptance of some laws among local populations, particularly in parts of the Philippines and Indonesia. These key root causes all contribute to illegal practices and corruption, and are resulting in severe resource depletion and degradation of water catchments, river, lacustrine, estuarine, coastal, and marine ecosystems. The Sulu-Sulawesi Sea forms a major geopolitical focus, with porous borders, transmigration, separatist movements, piracy, and illegal fishing all contributing to environmental degradation, human suffering and political instability, and inhibiting strong trilateral support for interventions. This review analyzes these multifarious environmental and socioeconomic impacts and their root causes, provides a future prognosis of status by 2020, and recommends policy options aimed at amelioration through sustainable management and development.

  4. A real options approach to biotechnology investment policy-the case of developing a Campylobacter vaccine to poultry.

    Science.gov (United States)

    Lund, Mogens; Jensen, Jørgen Dejgård

    2016-06-01

    The aim of the article is to identify and analyse public-private incentives for the development and marketing of new animal vaccines within a real options methodological framework, and to investigate how real options methodology can be utilized to support economic incentives for vaccine development in a cost-effective way. The development of a vaccine against Campylobacter jejuni in poultry is applied as a case study. Employing the real options methodology, the net present value of the vaccine R&D project becomes larger than a purely probabilistic expected present value throughout the different stages of the project - and the net present value becomes larger, when more types of real options are taken into consideration. The insight from the real options analysis reveals opportunities for new policies to promote the development of animal vaccines. One such approach might be to develop schemes combining stage-by-stage optimized subsidies in the individual development stages, with proper account taken of investors'/developers' economic incentives to proceed, sell or cancel the project in the respective stages. Another way of using the real options approach to support the development of desirable animal vaccines could be to issue put options for the vaccine candidate, enabling vaccine developers to hedge against the economic risk from market volatility.

  5. Climate policy through changing consumption choices: Options and obstacles for reducing greenhouse gas emissions

    NARCIS (Netherlands)

    Girod, B.; van Vuuren, D.P.; Hertwich, E.G.

    2014-01-01

    While national climate policy can address countries’ production or consumption, climate mitigation via changes in consumption has previously received relatively little attention in climate policy literature. In the absence of an effective international climate policy, the focus on consumption is

  6. A risk-based framework for water resource management under changing water availability, policy options, and irrigation expansion

    Science.gov (United States)

    Hassanzadeh, Elmira; Elshorbagy, Amin; Wheater, Howard; Gober, Patricia

    2016-08-01

    Long-term water resource management requires the capacity to evaluate alternative management options in the face of various sources of uncertainty in the future conditions of water resource systems. This study proposes a generic framework for determining the relative change in probabilistic characteristics of system performance as a result of changing water availability, policy options and irrigation expansion. These probabilistic characteristics can be considered to represent the risk of failure in the system performance due to the uncertainty in future conditions. Quantifying the relative change in the performance risk can provide a basis for understanding the effects of multiple changing conditions on the system behavior. This framework was applied to the water resource system of the Saskatchewan River Basin (SaskRB) in Saskatchewan, Canada. A "bottom-up" flow reconstruction algorithm was used to generate multiple realizations for water availability within a feasible range of change in streamflow characteristics. Consistent with observed data and projected change in streamflow characteristics, the historical streamflow was perturbed to stochastically generate feasible future flow sequences, based on various combinations of changing annual flow volume and timing of the annual peak. In addition, five alternative policy options, with and without potential irrigation expansion, were considered. All configurations of water availability, policy decisions and irrigation expansion options were fed into a hydro-economic water resource system model to obtain empirical probability distributions for system performance - here overall and sectorial net benefits - under the considered changes. Results show that no one specific policy can provide the optimal option for water resource management under all flow conditions. In addition, it was found that the joint impacts of changing water availability, policy, and irrigation expansion on system performance are complex and

  7. Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective.

    Science.gov (United States)

    Singh, Om Prakash; Singh, Bhawana; Chakravarty, Jaya; Sundar, Shyam

    2016-03-08

    Visceral leishmaniasis (VL) is a serious parasitic disease causing considerable mortality and major disability in the Indian subcontinent. It is most neglected tropical disease, particularly in terms of new drug development for the lack of financial returns. An elimination campaign has been running in India since 2005 that aim to reduce the incidence of VL to below 1 per 10,000 people at sub-district level. One of the major components in this endeavor is reducing transmission through early case detection followed by complete treatment. Substantial progress has been made during the recent years in the area of VL treatment, and the VL elimination initiatives have already saved many lives by deploying them effectively in the endemic areas. However, many challenges remain to be overcome including availability of drugs, cost of treatment (drugs and hospitalization), efficacy, adverse effects, and growing parasite resistance. Therefore, better emphasis on implementation research is urgently needed to determine how best to deliver existing interventions with available anti-leishmanial drugs. It is essential that the new treatment options become truly accessible, not simply available in endemic areas so that they may promote healing and save lives. In this review, we highlight the recent advancement and challenges in current treatment options for VL in disease endemic area, and discuss the possible strategies to improve the therapeutic outcome.

  8. Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective

    Institute of Scientific and Technical Information of China (English)

    Om Prakash Singh; Bhawana Singh; Jaya Chakravarty; Shyam Sundar

    2016-01-01

    Visceral leishmaniasis (VL) is a serious parasitic disease causing considerable mortality and major disability in the Indian subcontinent.It is most neglected tropical disease,particularly in terms of new drug development for the lack of financial returns.An elimination campaign has been running in India since 2005 that aim to reduce the incidence of VL to below 1 per 10,000 people at sub-district level.One of the major components in this endeavor is reducing transmission through early case detection followed by complete treatment.Substantial progress has been made during the recent years in the area of VL treatment,and the VL elimination initiatives have already saved many lives by deploying them effectively in the endemic areas.However,many challenges remain to be overcome including availability of drugs,cost of treatment (drugs and hospitalization),efficacy,adverse effects,and growing parasite resistance.Therefore,better emphasis on implementation research is urgently needed to determine how best to deliver existing interventions with available anti-leishmanial drugs.It is essential that the new treatment options become truly accessible,not simply available in endemic areas so that they may promote healing and save lives.In this review,we highlight the recent advancement and challenges in current treatment options for VL in disease endemic area,and discuss the possible strategies to improve the therapeutic outcome.

  9. Therapeutic options in pediatric non alcoholic fatty liver disease: current status and future directions

    Directory of Open Access Journals (Sweden)

    Vajro Pietro

    2012-10-01

    Full Text Available Abstract The epidemics of overweight and obesity has resulted in a significant increase of non alcoholic fatty liver disease (NAFLD, a potentially progressive condition. Currently, obesity related hepatopathy represents therefore the main cause of pediatric chronic liver disease. The first choice treatment at all ages is weight loss and/or lifestyle changes, however compliance is very poor and a pharmacological approach has become necessary. In the present article we present a systematic literature review focusing on established pediatric NALFD drugs (ursodeoxycholic acid, insulin sensitizers, and antioxidants and on innovative therapeutic options as well. Regarding the former ones, a pediatric pilot study highlighted that ursodeoxycholic acid is not efficient on transaminases levels and bright liver. Similarly, a recent large scale, multicenter randomized clinical trial (TONIC study showed that also insulin sensitizers and antioxidant vitamin E have scarce effects on serum transaminase levels. Among a large series of novel therapeutic approaches acting on recently proposed different pathomechanisms, probiotics seem hitherto the most interesting and reasonable option for their safety and tolerability. Toll-like receptors modifiers, Pentoxifylline, and Farnesoid X receptors agonists have been still poorly investigated, and will need further studies before becoming possible promising innovative therapeutic strategies.

  10. Haemodialysis catheter-related bloodstream infections: current treatment options and strategies for prevention.

    Science.gov (United States)

    Saxena, Anil K; Panhotra, Bodh R

    2005-03-05

    Regardless of the repeated reservations raised by countless researchers with reference to the use of catheters as vascular access for haemodialysis (HD), central venous catheters (CVCs) remain irreplaceable tools of the modern dialysis delivery system as a reliable option for the clinical situations requiring instant access to circulation, for various reasons. Patients on long-term haemodialysis are therefore at a significantly high risk for catheterrelated bloodstream infections (CRBSI) and ensuing serious complications. Although early systemic antibiotic treatment should include the coverage for Staphylococcus aureus, the pathogen with most devastating consequences including bacterial endocarditis; optimal treatment of CRBSI while preserving the catheter site, remains contentious. Nonetheless, catheter exchange over a guide wire and antimicrobial-anticoagulant "locks" have shown promising results as novel access salvage techniques. Despite the fact that a number of novel potentially useful strategies for the prevention of CRBSI are in the pipeline; equally essential however, remains the role of rigorous implementation of standard infection control measures for hygiene and aseptic handling of CVCs in long-term HD patients. The policy of increasing the AVF (arteriovenous fistula) prevalence beyond 50% while minimising the use of CVCs, dependent largely upon the timely referrals and prudently implemented pre-ESRD program - ought to have a positive impact on long-term HD outcomes.

  11. A European Perspective on Topical Ophthalmic Antibiotics: Current and Evolving Options

    Directory of Open Access Journals (Sweden)

    D. Bremond-Gignac

    2011-01-01

    Full Text Available Background Eye infections can be vision-threatening and must be treated effectively by appropriate and safe use of topical ophthalmic anti-infectives. This review will essentially consider the current and evolving treatment options for the various types of bacterial eye infections. Ocular surface bacterial infections affect subjects of all ages with a high frequency in newborns and children. Methods This article presents a review of the peer-reviewed published scientific literature in order to define the well-established uses of anti-infective eye drops in the field of ocular infections. A comprehensive search of the recent published literature including topical ophthalmic anti-infectives effective in bacterial ocular infections was performed. Clinical studies provide relevant data concerning the characteristics and clinical efficacy of antibacterial eye drops in ocular anterior segment infections or for perioperative prophylaxis. Publications were included to cover the current options of antibacterial eye drops available in Europe. Results Several recent publications identified effective topical ocular antibacterials requiring a reduced dose regimen and a short treatment course. Additional literature reviewed included data on novel perioperative prophylaxis, indications for topical fortified antibiotics and innovative research including the risk of resistance. Conclusions Safe and effective topical antibiotic eye drops for the treatment and prevention of ocular infections must be adapted to the type of bacteria suspected. Usual topical antimicrobials should be replaced by more recent and more effective treatments. The use of highly effective fluoroquinolones should be reserved for the most severe cases to avoid resistance. Short treatment courses, such as azithromycin, can be easily used in children, thereby improving quality of life.

  12. Policy options to reduce passenger car CO2 emissions after 2020

    Energy Technology Data Exchange (ETDEWEB)

    De Wilde, H.P.J.; Kroon, P. [ECN Beleidsstudies, Petten (Netherlands)

    2013-02-15

    The EU has set emission targets for new cars up to 2020 and is now preparing the post 2020 legislation. The present study aims to give insight in the design of policies to further reduce passenger car emissions after 2020. Internal combustion engine (ICE) vehicles are now expected to enable deeper and less costly CO2 emission reductions than envisioned until recently. However, even advanced ICE vehicles will not enable to meet the very stringent long term emission reduction targets for passenger cars. Therefore transport policies need not only to reduce emissions of ICE vehicles, but also ensure that electric and hydrogen vehicles are phased in timely, along with low-CO2 electricity and hydrogen. Current legislation to regulate tank-to-wheel vehicle emissions is based on CO2-limits, expressed in g CO2/km. On the short term it is important to maximize the efficiency of conventional vehicles. At the same time it is essential to foster the market introduction of electric and hydrogen vehicles, given their potential to reach eventually much deeper overall CO2-reductions. When the market share of electric and hydrogen vehicles grows it becomes increasingly important to maximize their efficiency and to minimize their upstream CO2 emissions. Maximizing both efficiency and overall CO2-performance of all vehicle types - ICE, electric, and hydrogen - will be complicated to achieve with a single CO2-based standard. At this point an efficiency-based standard is more effective, and may offer some additional benefits too. The current report provides basic directions of how such legislation could be shaped.

  13. Research-Informed Policy Options for Infant and Toddler Early Care and Education: Research-to-Policy Resources

    Science.gov (United States)

    Stephens, Samuel A.

    2016-01-01

    This Research-to-Policy Resource List compiles research-based policy documents published in 2010 and later on the following topics: Early learning guidelines for infants and toddlers; Program standards for settings serving infants and toddlers; Core competencies and credentials for caregivers of infants and toddlers; Use of infant/toddler…

  14. Financial considerations of policy options to enhance biomass utilization for reducing wildfire hazards

    Science.gov (United States)

    Dennis R. Becker; Debra Larson; Eini C. Lowell

    2009-01-01

    The Harvest Cost-Revenue Estimator, a financial model, was used to examine the cost sensitivity of forest biomass harvesting scenarios to targeted policies designed to stimulate wildfire hazardous fuel reduction projects. The policies selected represent actual policies enacted by federal and state governments to provide incentive to biomass utilization and are aimed at...

  15. Climate policy through changing consumption choices: Options and obstacles for reducing greenhouse gas emissions

    NARCIS (Netherlands)

    Girod, B.; van Vuuren, D.P.; Hertwich, E.G.

    2014-01-01

    While national climate policy can address countries’ production or consumption, climate mitigation via changes in consumption has previously received relatively little attention in climate policy literature. In the absence of an effective international climate policy, the focus on consumption is gai

  16. Economic instruments and waste policies in the Netherlands: Inventory and options for extended use

    NARCIS (Netherlands)

    Oosterhuis, F.; Bartelings, H.; Linderhof, V.G.M.; Beukering, van P.J.M.

    2009-01-01

    In recent years, the interest in the use of economic instruments in environmental policy has been growing, reflecting increasing awareness of their potential cost-effectiveness as well as the need to diversify the ‘policy toolbox’. Waste policy is no exception to this tendency. The present study exp

  17. Management options for pediatric patients who stutter: current challenges and future directions

    Directory of Open Access Journals (Sweden)

    Donaghy MA

    2016-07-01

    Full Text Available Michelle A Donaghy,1 Kylie A Smith,2,3 1Faculty of Health Sciences, Australian Catholic University, North Sydney, NSW, 2Murdoch Childrens Research Institute, Royal Childrens Hospital, 3Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia Abstract: Stuttering is a speech disorder, with onset often occurring in the preschool years. The prevalence of stuttering in young children is much higher than that in the general population, suggesting a high rate of recovery. However, we are unable to predict which children will recover without treatment, and it is widely acknowledged that stuttering therapy during childhood provides the best safeguard against chronic stuttering. This review reports on current evidence-based stuttering treatment options for preschoolers through to adolescents. We discuss the clinical challenges associated with treating pediatric clients who stutter at different stages of development and explore potential areas of treatment research that might serve to advance current clinical practice in the future. Keywords: stuttering, stammering, pediatric, therapy, evidence based

  18. Health services financing and delivery: analysis of policy options for Dubai, United Arab Emirates.

    Science.gov (United States)

    Hamidi, Samer

    2015-01-01

    A national health account (NHA) provides a systematic approach to mapping the flow of health sector funds within a specified health system over a defined time period. This article attempts to present a profile of health system financing in Dubai, United Arab Emirates using data from NHAs, and to compare the functional structures of financing schemes in Dubai with schemes in Qatar and selected member countries of the Organization for Economic Cooperation and Development (OECD). The author analyzed secondary data published in NHAs of Dubai and Qatar and data collected by the OECD countries and publicly available from Eurostat (Statistical Office of the European Union) of 25 OECD countries for comparative analysis. All health financing indicators used were as defined in the international System of Health Accounts (SHA). In Dubai, spending on inpatient care was the highest-costing component, with 30% of current health expenditures (CHE). Spending on outpatient care was the second highest-costing component and accounted for about 23% of the CHE. Household spending accounted for about 22% of CHE (equivalent to US$187 per capita), compared to an average of 20% of CHE of OECD countries. Dubai spent 0.02% of CHE on long-term care, compared to an average of 11% of CHE of OECD countries. Dubai spent about 6% of CHE on prevention and public health services, compared to an average of 3.2% of CHE of OECD countries. The findings point to potential opportunities for growth and improvement in several health policy issues in Dubai, including increasing focus and funding of preventive services; shifting from inpatient care to day surgery, outpatient, and home-based services and strengthening long-term care; and introducing cost-containment measures for pharmaceuticals. More investment in the translation of NHA data into policy is suggested for future researchers.

  19. CURRENT STATUS AND POLICY IMPLICATIONS FOR FOSTERING SOCIAL ENTREPRENEUR

    Directory of Open Access Journals (Sweden)

    Yoon-Doo Kim

    2012-01-01

    Full Text Available In this study, problems in current status of social entrepreneurs in Korea were examined and further policy issues for them were suggested as well. For the methodology, the study analyzed the drawbacks and policy implication of fostering social entrepreneurs through Focus Group Interview (FGI on analysis of present condition of incubating social entrepreneur and programs for it. First, it should escape from personnel expense-centered one and convert to ecosystem-centered or division-centered project in the direction of the government for fostering social entrepreneurs, putting emphasis on follow-up management and evaluation. Second, it must suggest a standard model for social entrepreneur promotion project. In other words, the projects with low performance should be reduced and education models appropriate for new circumstances and changes must be adopted through not only programs standardized in divisions, categories and local provinces, but also appointing expert instructors and project evaluation. Third, it’s necessary to propose specific guideline for detailed education operation according to education trainee and objectives of social entrepreneur. Fourth, it is needed to have more various contents development and distribution by strengthening support for specialized foundation, management and case studies related to fostering social entrepreneurs. Finally, it is even more required to spread awareness on social economics relating to programs for fostering social entrepreneur. With the long-term perspective, it is needed to render policy and specialization for fostering Korean-model social entrepreneurs, which is able to raise competent social entrepreneurs suitable for each stage of growth such as sourcing, incubation and launching social entrepreneurs.

  20. Health services financing and delivery: analysis of policy options for Dubai, United Arab Emirates

    Directory of Open Access Journals (Sweden)

    Hamidi S

    2015-02-01

    Full Text Available Samer Hamidi School of Health and Environmental Studies, Hamdan Bin Mohammed Smart University, Dubai, United Arab Emirates Introduction: A national health account (NHA provides a systematic approach to mapping the flow of health sector funds within a specified health system over a defined time period. This article attempts to present a profile of health system financing in Dubai, United Arab Emirates using data from NHAs, and to compare the functional structures of financing schemes in Dubai with schemes in Qatar and selected member countries of the Organization for Economic Cooperation and Development (OECD. Methods: The author analyzed secondary data published in NHAs of Dubai and Qatar and data collected by the OECD countries and publicly available from Eurostat (Statistical Office of the European Union of 25 OECD countries for comparative analysis. All health financing indicators used were as defined in the international System of Health Accounts (SHA. Results: In Dubai, spending on inpatient care was the highest-costing component, with 30% of current health expenditures (CHE. Spending on outpatient care was the second highest-costing component and accounted for about 23% of the CHE. Household spending accounted for about 22% of CHE (equivalent to US$187 per capita, compared to an average of 20% of CHE of OECD countries. Dubai spent 0.02% of CHE on long-term care, compared to an average of 11% of CHE of OECD countries. Dubai spent about 6% of CHE on prevention and public health services, compared to an average of 3.2% of CHE of OECD countries. Conclusion: The findings point to potential opportunities for growth and improvement in several health policy issues in Dubai, including increasing focus and funding of preventive services; shifting from inpatient care to day surgery, outpatient, and home-based services and strengthening long-term care; and introducing cost-containment measures for pharmaceuticals. More investment in the translation of

  1. The Hydraulic Option in Former Soviet Central Asia. Historical Perspective and Current Situation

    Directory of Open Access Journals (Sweden)

    Laura Vea Rodríguez

    2005-10-01

    Full Text Available This paper deals with the situation of water resource management in the five Central Asian republics that formed part of the USSR. By way of introduction, it lists the characteristics of water as a resource and then analyses the uses and distribution of water in the region.For this, it outlines a brief historical approach which helps to understand, in all its magnitude, the current situation of ecological degradation and how it determines living conditions in the region. Likewise, it deals with the policies of intervention in water resource management of the Central Asian states and of international institutions, and it includes the description of two specific case studies which form part of initiatives devoted to reversing a processwhich has led to the greatest ecological disaster on the planet, the most well-known aspect of which is the practical disappearance of the Aral Sea.

  2. Update on marine omega-3 fatty acids: management of dyslipidemia and current omega-3 treatment options.

    Science.gov (United States)

    Weintraub, Howard

    2013-10-01

    Low-density lipoprotein cholesterol (LDL-C) is currently the primary target in the management of dyslipidemia, and statins are first-line pharmacologic interventions. Adjunct therapy such as niacins, fibrates, bile acid sequestrants, or cholesterol absorption inhibitors may be considered to help reduce cardiovascular risk. This review discusses the need for alternative adjunct treatment options and the potential place for omega-3 fatty acids as such. The cardiovascular benefits of fish consumption are attributed to the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and a variety of omega-3 fatty acid products are available with varied amounts of EPA and DHA. The product types include prescription drugs, food supplements, and medical foods sourced from fish, krill, algal and plant oils or purified from these oils. Two prescription omega-3 fatty acids are currently available, omega-3 fatty acid ethyl esters (contains both EPA and DHA ethyl esters), and icosapent ethyl (IPE; contains high-purity EPA ethyl ester). A pharmaceutical containing free fatty acid forms of omega-3 is currently in development. Omega-3 fatty acid formulations containing EPA and DHA have been shown to increase LDL-C levels while IPE has been shown to lower triglyceride levels without raising LDL-C levels, alone or in combination with statin therapy. In addition, recent studies have not been able to demonstrate reduced cardiovascular risk following treatment with fibrates, niacins, cholesterol absorption inhibitors, or omega-3 fatty acid formulations containing both EPA and DHA in statin-treated patients; thus, there remains a need for further cardiovascular outcomes studies for adjunct therapy.

  3. NCBI Reference Sequences: current status, policy and new initiatives.

    Science.gov (United States)

    Pruitt, Kim D; Tatusova, Tatiana; Klimke, William; Maglott, Donna R

    2009-01-01

    NCBI's Reference Sequence (RefSeq) database (http://www.ncbi.nlm.nih.gov/RefSeq/) is a curated non-redundant collection of sequences representing genomes, transcripts and proteins. RefSeq records integrate information from multiple sources and represent a current description of the sequence, the gene and sequence features. The database includes over 5300 organisms spanning prokaryotes, eukaryotes and viruses, with records for more than 5.5 x 10(6) proteins (RefSeq release 30). Feature annotation is applied by a combination of curation, collaboration, propagation from other sources and computation. We report here on the recent growth of the database, recent changes to feature annotations and record types for eukaryotic (primarily vertebrate) species and policies regarding species inclusion and genome annotation. In addition, we introduce RefSeqGene, a new initiative to support reporting variation data on a stable genomic coordinate system.

  4. Climate Change Scientific Assessment and Policy Analysis. Integrating agriculture, forestry and other land use in future climate regimes. Methodological issues and policy options

    Energy Technology Data Exchange (ETDEWEB)

    Trines, E. [Treeness Consult, Austerlitz (Netherlands); Hoehne, N.; Jung, M. [Ecofys, Koeln (Netherlands); Skutsch, M. [KuSiNi Foundation, Enschede (Netherlands); Petsonk, A.; Silva-Chavez, G. [Environmental Defense, Washington DC (United States); Smith, P. [School of Biological Sciences, University of Aberdeen, Aberdeen (United Kingdom); Nabuurs, G.J. [Alterra, Wageningen (Netherlands); Verweij, P. [Science, Technology and Society, Faculty of Science, Copernicus Institute for Sustainable Development and Innovation, University of Utrecht, Utrecht (Netherlands); Schlamadinger, B. [Joanneum Research, Graz (Austria)

    2006-10-15

    The current agreement under the UNFCCC and its Kyoto Protocol takes a fragmented approach to emissions and removals from Agriculture, Forestry and Other Land Use (AFOLU): not all activities, not all gases and not all lands are included. Also, net removals can be used to offset emissions from other sectors as the sector 'Land-Use Change and Forestry' (LUCF) is not an integral part of the 'quantified emission limitations or reduction commitments' or targets to which Parties included in Annex I to the UNFCCC have committed themselves. The emissions in the AFOLU sector are significant and are predominantly located in non-Annex I countries. Having a large amount of emissions means there is also a significant mitigation potential in those countries. On the other side of the equation, if nations want to keep the option open to achieve the ultimate objective of the UNFCCC within a reasonable timeframe, the cut in emissions required under a possible post 2012 climate change mitigation regime needs to be significantly deeper compared to what has been agreed for the first commitment period under the Kyoto Protocol. Adding up these two aspects means that AFOLU needs to be brought into the equation. This could only ever be acceptable to non-Annex I Parties if this would not hinder their development but would rather propel it. Therefore, it should not lead to commitments for non-Annex I countries but be a tempting opportunity to improve national circumstances and to access (economic) benefits that result from an engagement in such an agreement. This report presents five policy options that can be employed by non-Annex I Parties on a voluntary basis, at a moment of their choice, that will lead to a broader and deeper participation under a possible post 2012 climate regime without hindering but rather promoting their development, whilst at the same time enabling Annex I parties to take on commitments that lead to deeper cuts in emissions.

  5. An overview of the current surgical options for pineal region tumors

    Directory of Open Access Journals (Sweden)

    Waleed A Azab

    2014-01-01

    Full Text Available Background: The list of pineal region tumors comprises an extensive array of pathological entities originating within one of the most complex areas of the intracranial cavity. With the exception of germ cell tumors, microsurgical excision is still nowadays the mainstay of management for most pineal region tumors. Methods: A search of the medical literature was conducted for publications addressing surgical options for management of pineal region tumors. Results: The infratentorial supracerebellar and the occipital transtentorial approaches are currently the most frequently used approaches for pineal region tumors. Endoscopic tumor biopsy with simultaneous endoscopic third ventriculostomy has emerged as a minimally invasive and highly effective strategy for initial management since it addresses the issue of tissue diagnosis and offers a solution for the associated hydrocephalus frequently encountered in these patients. Endoscope-assisted microsurgery and purely endoscopic excision have been reported in few reports and are likely to be more utilized in the future. Conclusion : Preoperative planning is very crucial and should most importantly be individualized according to the anatomical features of the lesion and structures encountered during the procedure.

  6. Addressing Therapeutic Options for Ebola Virus Infection in Current and Future Outbreaks.

    Science.gov (United States)

    Haque, Azizul; Hober, Didier; Blondiaux, Joel

    2015-10-01

    Ebola virus can cause severe hemorrhagic disease with high fatality rates. Currently, no specific therapeutic agent or vaccine has been approved for treatment and prevention of Ebola virus infection of humans. Although the number of Ebola cases has fallen in the last few weeks, multiple outbreaks of Ebola virus infection and the likelihood of future exposure highlight the need for development and rapid evaluation of pre- and postexposure treatments. Here, we briefly review the existing and future options for anti-Ebola therapy, based on the data coming from rare clinical reports, studies on animals, and results from in vitro models. We also project the mechanistic hypotheses of several potential drugs against Ebola virus, including small-molecule-based drugs, which are under development and being tested in animal models or in vitro using various cell types. Our paper discusses strategies toward identifying and testing anti-Ebola virus properties of known and medically approved drugs, especially those that can limit the pathological inflammatory response in Ebola patients and thereby provide protection from mortality. We underline the importance of developing combinational therapy for better treatment outcomes for Ebola patients.

  7. Current treatment options for gastroenteropancreatic neuroendocrine tumors with a focus on the role of lanreotide.

    Science.gov (United States)

    Kos-Kudła, Beata; Ćwikła, Jarosław; Ruchała, Marek; Hubalewska-Dydejczyk, Alicja; Jarzab, Barbara; Krajewska, Jolanta; Kamiński, Grzegorz

    2017-01-01

    Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a large and very diverse group of neoplasms. Clinical presentation of NETs depends on the site of the primary tumor and whether the tumor is functioning (i.e., secreting peptides or neuroamines that produce symptoms). The diagnosis of GEP-NET is further complicated by symptomatic differences that occur depending on the type of secreted peptide or neuroamine. Due to their heterogeneity and unique characteristics, early diagnosis of GEP-NETs is difficult, which increases the likelihood of metastatic disease and reduces the scope of therapeutic possibilities. Thus, a multidisciplinary approach for the treatment of GEP-NETs is necessary. This review is the result of presentations that were delivered during an expert meeting on the treatment of GEP-NETs supported by Ipsen. We summarize the current knowledge on the epidemiology, incidence, diagnosis, and treatment of GEP-NETs. We examined the role of the somatostatin analog (SSA) lanreotide and the impact of the data from the recently published, randomized, double-blind, placebo-controlled CLARINET study (Controlled study of Lanreotide Antiproliferative Response In Neuroendocrine Tumors) on disease management. We also review the recent treatment options and recommendations for GEP-NETs.

  8. Current and emerging treatment options for the elderly patient with chronic kidney disease

    Directory of Open Access Journals (Sweden)

    Fassett RG

    2014-01-01

    Full Text Available Robert G Fassett The University of Queensland School of Human Movement Studies, Brisbane, Queensland, Australia Abstract: The objective of this article is to review the current and emerging treatments of CKD prior to dialysis in the elderly. Worldwide, there are increasing numbers of people who are aged over 65 years. In parallel, there are increasing numbers of elderly patients presenting with chronic kidney disease (CKD, particularly in the more advanced stages. The elderly have quite different health care needs related to their associated comorbidity, frailty, social isolation, poor functional status, and cognitive decline. Clinical trials assessing treatments for CKD have usually excluded patients older than 70–75 years; therefore, it is difficult to translate current therapies recommended for younger patients with CKD across to the elderly. Many elderly people with CKD progress to end-stage kidney disease and face the dilemma of whether to undertake dialysis or accept a conservative approach supported by palliative care. This places pressure on the patient, their family, and on health care resources. The clinical trajectory of elderly CKD patients has in the past been unclear, but recent evidence suggests that many patients over 75 years of age with multiple comorbidities have greatly reduced life expectancies and quality of life, even if they choose dialysis treatment. Offering a conservative pathway supported by palliative care is a reasonable option for some patients under these circumstances. The elderly person who chooses to have dialysis will frequently have different requirements than younger patients. Kidney transplantation can still result in improved life expectancy and quality of life in the elderly, in carefully selected people. There is a genuine need for the inclusion of the elderly in CKD clinical trials in the future so we can produce evidence-based therapies for this group. In addition, new therapies to treat and slow CKD

  9. 76 FR 38399 - Assessing the Current Research, Policy, and Practice Environment in Public Health Genomics

    Science.gov (United States)

    2011-06-30

    ... HUMAN SERVICES Centers for Disease Control and Prevention Assessing the Current Research, Policy, and..., and other information helpful to assess the current research, policy, and practice environment in... Control and Prevention (CDC) has worked to integrate genomics into public health research, policy,...

  10. Study of the Option Ordering Policy concerning Perishable Farm Produce Based on Revenue Sharing Contract

    Institute of Scientific and Technical Information of China (English)

    Xiaojing; LIU

    2014-01-01

    This paper considers the two-echelon supply chain system which consists of single agricultural producers and retailers,and analyzes the impact of sharing ratio on the option ordering quantity,and retailers and producers’ expected profits.Studies have shown that in the case of decentralization,when the revenue sharing ratio is between 0 and 0.3,the option ordering quantity of farm produce is a decreasing function of the sharing ratio; when the revenue sharing ratio is between 0.3 and 1,the option ordering quantity of farm produce is an increasing function of sharing ratio; when the revenue sharing ratio is between 0.421 and 1,the agricultural producers and retailers’ expected profits are an increasing function of sharing ratio.Finally,through the numerical calculation,the applicability of the conclusions is verified,to provide a reference for the supply chain management practices.

  11. Residential Water Scarcity in Cyprus: Impact of Climate Change and Policy Options

    Directory of Open Access Journals (Sweden)

    Theodoros Zachariadis

    2010-10-01

    Full Text Available This paper presents an assessment of the cost of water scarcity in Cyprus, today and in the next 20 years, taking into account the effect of projected climate change in the region. It focuses on the residential sector, accounting also for tourism and industry. Using a simple demand function, total scarcity costs in Cyprus are computed for the period 2010–2030, and three scenarios of future water demand are presented. The central estimate shows that the present value of total costs due to water shortages will amount to 72 million Euros (at 2009 prices, and, if future water demand increases a little faster, these costs may reach 200 million Euros. Using forecasts of regional climate models, costs are found to be about 20% higher in a “climate change” scenario. Compared to the loss of consumer surplus due to water shortages, desalination is found to be a costly solution, even if environmental damage costs from the operation of desalination plants are not accounted for. Finally, dynamic constrained optimization is employed and shows that efficient residential water prices should include a scarcity price of about 40 Eurocents per cubic meter at  2009 prices; this would constitute a 30–100% increase in current prices faced by residential consumers. Reductions in rainfall due to climate change would raise this price by another 2-3 Eurocents. Such a pricing policy would provide a clear long-term signal to consumers and firms and could substantially contribute to a sustainable use of water resources in the island.

  12. Policies for second generation biofuels: current status and future challenges

    Energy Technology Data Exchange (ETDEWEB)

    Egger, Haakan; Greaker, Mads; Potter, Emily

    2011-07-01

    Current state-of-the-art knowledge concludes that green house gas (GHG) emissions must be controlled and reduced within the next 30-40 years. The transport sector contributes almost a fifth of the current global emissions, and its share is likely to increase in the future. The US and a number of European countries have therefore introduced various support schemes for research and development (RandD) of low emission fuels that can potentially replace the current fossil fuels. One such alternative is biofuels. The advantage of biofuels are that it is easy to introduce into the transport sector. On the other hand, recent research papers question whether the supply of feedstock is sufficient, and to what extent biofuels lead to GHG emission reductions. This report reviews the current status of second generation biofuels. Second generation biofuels are made from cellulose, which according to our survey of the literature, is in more abundant supply than the first generation biofuels feedstocks. Furthermore, it seems to have the potential to reduce GHG emissions from the transport sector without leading to devastating land use changes, which recent critique has held against first generation biofuels. Given that governments have decided to support RandD of low emission fuels, we ask the following questions: Should second generation biofuels receive RandD support to the same extent as other low emission fuels like hydrogen? How should support schemes for second generation biofuels be designed? Second generation biofuels can be divided according to the production process into thermo-chemical and bio-chemical. With respect to the thermo-chemical process the potential for cost reductions seems to be low. On the other hand, ethanol made from cellulose using the biochemical conversion process is far from a ripe technology. Expert reports point to several potential technological breakthroughs which may reduce costs substantially. Hence, cellulosic ethanol, should receive direct

  13. Policy Options for Private Forest Owners in Western Balkans: A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Mersudin AVDIBEGOVIĆ

    2010-06-01

    Full Text Available Private forest owners start to play an important role in Western Balkans’ forestry and they are essential to the successful implementation of environmental policies. Little is known about how forest policy can support private forest owners in these countries and therefore this study was conducted though a qualitative method, based on personal interviews with representatives of 54 stakeholders that include state forest authorities and administration, private forest owners associations, forest science and research and private sector in Bosnia Herzegovina, Croatia and Serbia. The results show significant homogeneity across the region towards creation of independent interest forest owners associations based on financial support. Regression analysis identified stakeholder attitudes as significant predictors of policy preferences and also identified owners of production forest as more supportive of such policies

  14. Demographic Consequences of Gender Discrimination in China: Simulation Analysis of Policy Options

    OpenAIRE

    Quanbao, Jiang; Shuzhuo, Li; Marcus W., Feldman

    2011-01-01

    The large number of missing females in China, a consequence of gender discrimination, is having and will continue to have a profound effect on the country's population development. In this paper, we analyze the causes of this gender discrimination in terms of institutions, culture and, economy, and suggest public policies that might help eliminate gender discrimination. Using a population simulation model, we study the effect of public policies on the sex ratio at birth and excess female chil...

  15. Tobacco Town: Computational Modeling of Policy Options to Reduce Tobacco Retailer Density

    Science.gov (United States)

    Luke, Douglas A.; Hammond, Ross A.; Combs, Todd; Sorg, Amy; Kasman, Matt; Mack-Crane, Austen; Ribisl, Kurt M.; Henriksen, Lisa

    2017-01-01

    Objectives To identify the behavioral mechanisms and effects of tobacco control policies designed to reduce tobacco retailer density. Methods We developed the Tobacco Town agent-based simulation model to examine 4 types of retailer reduction policies: (1) random retailer reduction, (2) restriction by type of retailer, (3) limiting proximity of retailers to schools, and (4) limiting proximity of retailers to each other. The model examined the effects of these policies alone and in combination across 4 different types of towns, defined by 2 levels of population density (urban vs suburban) and 2 levels of income (higher vs lower). Results Model results indicated that reduction of retailer density has the potential to decrease accessibility of tobacco products by driving up search and purchase costs. Policy effects varied by town type: proximity policies worked better in dense, urban towns whereas retailer type and random retailer reduction worked better in less-dense, suburban settings. Conclusions Comprehensive retailer density reduction policies have excellent potential to reduce the public health burden of tobacco use in communities. PMID:28398792

  16. Policies and design elements for the repowering of wind farms: A qualitative analysis of different options

    Energy Technology Data Exchange (ETDEWEB)

    Rio, Pablo del, E-mail: pablo.delrio@cchs.csic.e [Consejo Superior de Investigaciones Cientificas, Calle Albasanz 26-28, Madrid 28037 (Spain); Calvo Silvosa, Anxo, E-mail: calvo@udc.e [Universidade da Coruna, Departamento de Economia Financeira e Contabilidade, Campus de Elvina s/n, A Coruna 15071 (Spain); Iglesias Gomez, Guillermo, E-mail: gwig@udc.e [Universidade da Coruna, Departamento de Economia Aplicada I, Campus de Elvina s/n, A Coruna 15071 (Spain)

    2011-04-15

    Repowering of a wind farm is the process of replacing existing wind turbines with new turbines that either have a larger nameplate capacity or more efficiency, resulting in a net increase of the power generated. Although repowering brings, both, social and private benefits, there are also several obstacles to repowering which justify public support. The aim of this paper is to provide an overview and a qualitative analysis of instruments and design options to support repowering of on-shore wind farms. The multicriteria analysis carried out in this paper shows that all instruments have their advantages and drawbacks. However, feed-in tariffs and investment subsidies seem to be particularly appropriate instruments in this regard. Furthermore, we provide an assessment of different design options to promote repowering according to key assessment criteria. The relevance of design elements hinges on the fact that these are the ones directly affecting the variables that are relevant in the decision to repower (capacity factors and investment costs). - Research highlights: {yields} This paper provides a qualitative analysis of instruments and design options to support repowering in wind farms. {yields} The multicriteria analysis has shown that all instruments have their advantages and drawbacks regarding promotion of repowering. {yields} However, feed-in tariffs and investment subsidies seem to be particularly appropriate instruments in this regard. {yields} The choice of design elements within instruments is at least as important to promote repowering as the choice of specific instruments.

  17. Managing health professional migration from sub-Saharan Africa to Canada: a stakeholder inquiry into policy options

    Science.gov (United States)

    Labonté, Ronald; Packer, Corinne; Klassen, Nathan

    2006-01-01

    Background Canada is a major recipient of foreign-trained health professionals, notably physicians from South Africa and other sub-Saharan African countries. Nurse migration from these countries, while comparatively small, is rising. African countries, meanwhile, have a critical shortage of professionals and a disproportionate burden of disease. What policy options could Canada pursue that balanced the right to health of Africans losing their health workers with the right of these workers to seek migration to countries such as Canada? Methods We interviewed a small sample of émigré South African physicians (n = 7) and a larger purposive sample of representatives of Canadian federal, provincial, regional and health professional departments/organizations (n = 25); conducted a policy colloquium with stakeholder organizations (n = 21); and undertook new analyses of secondary data to determine recent trends in health human resource flows between sub-Saharan Africa and Canada. Results Flows from sub-Saharan Africa to Canada have increased since the early 1990s, although they may now have peaked for physicians from South Africa. Reasons given for this flow are consistent with other studies of push/pull factors. Of 8 different policy options presented to study participants, only one received unanimous strong support (increasing domestic self-sufficiency), one other received strong support (increased health system strengthening in source country), two others mixed support (voluntary codes on ethical recruitment, bilateral or multilateral agreements to manage flows) and four others little support or complete rejection (increased training of auxiliary health workers in Africa ineligible for licensing in Canada, bonding, reparation payments for training-cost losses and restrictions on immigration of health professionals from critically underserved countries). Conclusion Reducing pull factors by improving domestic supply and reducing push factors by strengthening source

  18. Relevance Between City Size and Tra c Congestion and Its Policy Options

    Institute of Scientific and Technical Information of China (English)

    SONG Bo; ZHAO Min; LI Caige

    2012-01-01

    The study finds that,the traffic congestion will worsen along with the expansion of city size,if the factors of traffic structure,proportion of urban road area,spatial distribution of city traveling,and occurrence intensity of travel are fixed.Therefore,the need for certain public policies and intervention of urban transportation is related with city size.It is an unavoidable and urgent task for the governments of large and supper cities to formulate and implement scientific transportation policies in order to guarantee the operation efficiency of urban transportation system.

  19. Shifting currents: Progress, setbacks, and shifts in policy and practice

    Science.gov (United States)

    ,; Dunning, Charles; Robertson, Dale

    2016-01-01

    clean water future. More than a decade has passed since our first statewide WOW conversation and the report that captured recommendations from its participants: Waters of Wisconsin: The Future of Our Aquatic Ecosystems and Resources. Drawing from a diverse and growing set of stakeholders from across the state, the Wisconsin Academy initiated a new conversation in 2012 (known as WOW II) to assess progress in regard to our 2003 recommendations. We also sought to review the status of waters in Wisconsin today. The result of this renewed conversation is Shifting Currents: Progress, Setbacks, and Shifts in Policy and Practice. The new report assesses progress in brief, and explores in greater depth the continuing and emerging challenges to water quality, supply, and aquatic ecosystems in Wisconsin.In this report, we first review the context and frameworks for public decision-making about water and then examine some of the root causes—or “drivers”—and ecological stressors that underlie many of the symptoms we see in the form of pollution or ecosystem degradation in Wisconsin. This is followed by a summary of current water issues, many of which had been identified in the 2003 report and remain relevant today. We examine progress since 2003 but also setbacks, and discuss issues that we are likely to continue to face in the coming decades, including controlling agricultural runoff, mitigating climate change and grappling with its effects on the state’s waters, protecting groundwater from bacterial contamination and other pollutants, and preventing groundwater depletion. We also attempt to anticipate issues on the horizon. We offer a deeper look at some particular challenges, such as phosphorus pollution and groundwater contamination. We then consider the current decision-making framework and how it is shaping our capacity to respond to water challenges in Wisconsin. Finally, we offer recommendations and identify opportunities to safeguard Wisconsin’s waters in the

  20. Lay People's Views of School Food Policy Options: Associations with Confidence, Personal Values and Demographics

    Science.gov (United States)

    Worsley, Anthony

    2006-01-01

    A random population survey administered by mail to examine lay people's views of children's food policies and their associations with demographics, personal values and confidence in authorities was conducted among adults in Victoria, Australia. Three hundred and seventy-seven people responded (response rate 57.6%). The questionnaire contained 35…

  1. Digital platforms: an analytical framework for identifying and evaluating policy options

    NARCIS (Netherlands)

    van Eijk, N.; Fahy, R.; van Til, H.; Nooren, P.; Stokking, H.; Gelevert, H.

    2015-01-01

    At the request of the Ministry of Economic Affairs, a project consortium of TNO, Ecorys and IViR have developed a framework to analyse policy questions regarding ‘digital platforms’. This framework enables the government to take advantage of the opportunities these platforms offer and to appreciate

  2. Sensitising rural policy: Assessing spatial variation in rural development options for Europe

    NARCIS (Netherlands)

    Berkel, van D.B.; Verburg, P.H.

    2011-01-01

    Regional distinctiveness is supported by the European Union in rural development policy. However, there is little information about the spatial distribution of the potential for rural development across Europe. The concept of territorial capital is used to consider spatial characteristics in assessi

  3. Policy options to stimulate social innovation initiatives addressing food waste prevention and reduction

    NARCIS (Netherlands)

    Vittuari, Matteo; Gaiani, Silvia; Politano, Alessandro; Timmermans, A.J.M.; Bos-Brouwers, H.E.J.

    2016-01-01

    The report builds on the knowledge created by the FUSIONS position paper “Stimulating social innovation through policy measures” that uses as key inputs the range of existing social innovation initiatives catalogued by FUSIONS WP4 in the inventory and draws on the outcomes of the WP3 Social Camp

  4. Policy options to stimulate social innovation initiatives addressing food waste prevention and reduction

    NARCIS (Netherlands)

    Vittuari, Matteo; Gaiani, Silvia; Politano, Alessandro; Timmermans, A.J.M.; Bos-Brouwers, H.E.J.

    2016-01-01

    The report builds on the knowledge created by the FUSIONS position paper “Stimulating social innovation through policy measures” that uses as key inputs the range of existing social innovation initiatives catalogued by FUSIONS WP4 in the inventory and draws on the outcomes of the WP3 Social Camp eve

  5. Digital platforms: an analytical framework for identifying and evaluating policy options

    NARCIS (Netherlands)

    van Eijk, N.; Fahy, R.; van Til, H.; Nooren, P.; Stokking, H.; Gelevert, H.

    2015-01-01

    At the request of the Ministry of Economic Affairs, a project consortium of TNO, Ecorys and IViR have developed a framework to analyse policy questions regarding ‘digital platforms’. This framework enables the government to take advantage of the opportunities these platforms offer and to appreciate

  6. Current and emerging treatment options for castration-resistant prostate cancer: a focus on immunotherapy

    NARCIS (Netherlands)

    Gerritsen, W.R.; Sharma, P.

    2012-01-01

    BACKGROUND: Castration-resistant prostate cancer is a disease with limited treatment options. However, the ongoing elucidation of the mechanisms underlying this disease continues to support the development of not only novel agents, but also innovative approaches. Among these therapies, immunotherapy

  7. Central retinal vein occlusion: A review of current Evidence-based treatment options

    Directory of Open Access Journals (Sweden)

    Amy Patel

    2016-01-01

    Full Text Available A central retinal vein occlusion (CRVO can induce an ischemic and hypoxic state with resulting sequelae of macular edema and neovascularization. Many treatment options have been studied. Our review aims to investigate the safety and efficacy of the multiple treatment options of CRVO. A PubMed and Cochrane literature search was performed. Well-controlled randomized clinical trials that demonstrated strong level 1 evidence-based on the rating scale developed by the British Centre for Evidence-Based Medicine were included. Seven clinical trials met inclusion criteria to be included in this review. These included studies that investigated the safety and efficacy of retinal photocoagulation (1 study, intravitreal steroid treatment (2 studies, and antivascular endothelial growth factor treatment (4 studies for the treatment of CRVO. In addition, studies evaluating surgical treatment options for CRVO were also included. Many treatment modalities have been demonstrated to be safe and efficacious in the treatment of CRVO. These treatment options offer therapeutic benefits for patients and clinically superior visual acuity and perhaps the quality of life after suffering from a CRVO.

  8. Getting Ahead: Current Secondary and Postsecondary Acceleration Options for High-Ability Students in Indiana

    Science.gov (United States)

    Peters, Scott J.; Mann, Rebecca L.

    2009-01-01

    The International Baccalaureate and concurrent enrollment programs are both options available for high-ability high school students. Their value lies in their potential to provide greater depth and breadth of curriculum than is traditionally possible in public high schools. This study surveyed public school corporations in Indiana to examine the…

  9. Policy Options for Encouraging Energy Efficiency Best Practices in Shandong Province's Cement Industry

    Energy Technology Data Exchange (ETDEWEB)

    Price, Lynn [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Zhou, Nan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lu, Hongyou [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sambeek, Emiel van [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yowargana, Ping [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Shuang, Liu [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kejun, Jiang [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-07-12

    This research intends to explore possible design options for a sectoral approach in the cement sector in Shandong Province and to consider its respective advantages and disadvantages for future application. An effort has been made in this research to gather and analyze data that will provide a transparent and robust basis for development of a Business-As-Usual (BAU) scenario, maximum technology potential scenario, and ultimately a sector crediting baseline. Surveys among cement companies and discussions with stakeholders were also conducted in order to better understand the industry and local needs related to the sectoral approach.

  10. What's Yours Is Mine: An Investigation of Current Copyright Policies of Education Journals

    Science.gov (United States)

    Meyer, Katrina A.

    2009-01-01

    This research investigated the current copyright policies of 21 education journals published by academic societies, universities and university presses, and commercial publishers. For the sample I chose only journals with a copyright policy on the journal or publisher web site, and I then analyzed the content of the policies in order to answer…

  11. A third option for climate policy within potential limits to growth

    Science.gov (United States)

    van den Bergh, Jeroen C. J. M.

    2017-02-01

    Climate change has revived debates around the concept of limits to growth, 45 years after it was first proposed. Many citizens, scientists and politicians fear that stringent climate policy will harm economic growth. Some are anti-growth, whereas others believe green growth is compatible with a transition to a low-carbon economy. As the window to curb warming at 2 °C closes, this debate will intensify. This Review critically reflects on both positions, providing an overview of existing literature on the growth versus climate debate. Both positions are argued here to jeopardize environmental or social goals. A third position, labelled an 'agrowth' strategy, is proposed to depolarize the debate and reduce resistance to climate policies.

  12. Analysis Of Policy Options To Convert Human-Elephant Conflict Into Human-Elephant Harmony

    OpenAIRE

    Rawadee Jarungrattanapong; Siriporn Sajjanand

    2011-01-01

    In Thailand the number of elephants are declining, and many of the remaining animals are protected in a network of wildlife sanctuaries. Unfortunately, elephants from these protected areas are coming into conflict with farmers. This human-elephant conflict (HEC) is causing crop damage. It is also leading to injury and loss of life amongst both farmers and elephants. This study has looked at this problem and has highlighted a combination of policies that should help to reduce it. It finds that...

  13. Ethnic Conflict in Central Europe and the Balkans: A Framework and U.S. Policy Options

    Science.gov (United States)

    1994-01-01

    relevance of nationality based on ethnic lines. For example, Germany has retained exclusivist policies regarding the acquisition of citizenship, stemming...that in the western part of Europe. Frustrated Nationalism The exclusivist tendencies inherent in ethnic nationalism in the cen- tral part of Europe...Ethnic Nationalism Under Communism Communist domination of the region did not result in the elimina- tion of the exclusivist ethnic nationalist

  14. Global Food Crisis & Inflationary Pressures: Short and Medium to Long Term Policy Options

    OpenAIRE

    Abbas, Syed Kanwar

    2008-01-01

    The present paper is an initiative to pin down major factors behind exorbitant inflationary pressures in the global economy. The paper mentions that among other factors productivity shocks, external shocks, inflationary expectations and conversion of food crops into fuel generation are the major drivers of inflation (especially food inflation) in the present inflationary era. An attempt is also made to offer some short and medium to long term policy recommendations in this regard. Especially,...

  15. ON THE CURRENT RMB EXCHANGE RATE REGIME AFFECTING THE EFFECTIVENESS OF MONETARY POLICY

    Institute of Scientific and Technical Information of China (English)

    黄燕君

    2001-01-01

    The current exchange rate regime of China is just like the US dollar-pegged exchange rate regime, which weakens the effectiveness of monetary policy but increases the effectiveness of fiscal policy. Since the scope of implementing the fiscal policy is quite narrow, it is necessary to promote the effectiveness of monetary policy by enlarging the elasticity of the RMB exchange rate regime so as to stimulate the rapid development of the Chinese economy effectively.

  16. Preferences on policy options for ensuring the financial sustainability of health care services in the future: results of a stakeholder survey.

    Science.gov (United States)

    Tordrup, David; Angelis, Aris; Kanavos, Panos

    2013-12-01

    Universal access to health care in most western European countries has been a given for many decades; however, macroeconomic developments and increased pressure on health care budgets could mean the status quo cannot be maintained. As populations age, a declining proportion of economically active citizens are being required to support a larger burden of health and social care, while increasing availability of novel technologies for extending and improving life continues to push health care costs upwards. With health expenditure continuing to rise as a proportion of national income, concerns are raised about the current and future financial sustainability of Organisation for Economic Co-Operation and Development (OECD) health care systems. Against this backdrop, a discussion about options to fund health care in the future, including whether to raise additional health care finance (and the ways to do so), reallocate resources and/or ration services becomes very pertinent. This study elicits preferences among a group of key stakeholders (payers, providers, government, academia and health-related industry) on the issue of health care financial sustainability and the future funding of health care services, with a view to understanding the different degrees of acceptability between policy interventions and future funding options as well as their feasibility. We invited 842 individuals from academia, other research organisations (eg. think tanks), national health services, providers, health insurance organisations, government representatives and health-related industry and related advisory stakeholders to participate in an online survey collecting preferences on a variety of revenue-generating mechanisms and cost/demand reducing policies. Respondents represented the 28 EU member states as well as Norway, Iceland, Switzerland, Australia, Russian Federation, Canada and New Zealand. We received 494 responses to our survey from all stakeholder groups. Across all groups, the

  17. The Future of the International Investment Law and Policy Re-gime:Options for Improvement

    Institute of Scientific and Technical Information of China (English)

    Karl P.Sauvant; Federico Ortino

    2014-01-01

    The international investment regime faces broader chal-lenges, as reflected especially in the discussions regarding the investor-state dispute-settlement mechanism and the quest to make the international investment regime more oriented toward sustainable development objectives and to strengthen disciplines for the behavior of multinational enterprises. A number of options of how the regime can be improved are laid out in this article, including engaging in fact finding processes; establishing consen-sus-building working groups; formulating a model international investment agreement; building specific mechanisms to improve the investment re-gime;and commencing intergovernmental processes.An international in-vestment consensus-building process is advocated to facilitate the improve-ment of the international investment regime.

  18. Poliomyelitis in the United States: A Historical Perspective and Current Vaccination Policy.

    Science.gov (United States)

    Farizo, Karen M.; And Others

    1990-01-01

    Examines poliomyelitis in the United States by reviewing clinical manifestations and outcomes, history, recent epidemiologic characteristics, characteristics of currently available vaccines, controversies surrounding vaccination policy, current poliovirus vaccination recommendations, and prospects for worldwide eradication. Poliomyelitis remains…

  19. Who Owns Renewable Energy Certificates? An Exploration of PolicyOptions and Practice

    Energy Technology Data Exchange (ETDEWEB)

    Holt, Edward A.; Wiser, Ryan; Bolinger, Mark

    2006-04-05

    Renewable energy certificates (RECs) represent the bundle of information that describes the characteristics of renewable electricity generation, and may be (and increasingly are) sold separately from the underlying electricity itself. RECs are a relatively new phenomenon, emerging as a tradable commodity in voluntary markets in the late 1990s, and gaining strength as a means of compliance with various state policy requirements affecting renewable generation in the early 2000s (Holt and Bird 2005). Twenty states and Washington, D.C. now have mandatory renewables portfolio standard (RPS) obligations, and most of these may be satisfied by owning and retiring RECs. Many states also have fuel source and emissions disclosure requirements, for which RECs are useful. Even where state policy does not allow unbundled and fully tradable RECs to meet these requirements, RECs may still be used as an accounting and verification tool (REC tracking systems are in place or under development in many regions of the U.S.). These applications, plus REC trading activity in support of voluntary green claims, give rise to potential ''double counting'' to the extent that the purchaser of the RECs and the purchaser of the underlying electricity both make claims to the renewable energy attributes of the facility in question (Hamrin and Wingate 2003). When renewable electricity is sold and purchased, an important question therefore arises: ''Who owns the RECs created by the generation of renewable energy?'' In voluntary transactions, most agree that the question of REC ownership can and should be negotiated between the buyer and the seller privately, and should be clearly established by contract. Claims about purchasing renewable energy should only be made if REC ownership can be documented. In many other cases, however, renewable energy transactions are either mandated or encouraged through state or federal policy. In these cases, the issue of REC

  20. Sensitive But Unclassified Information and Other Controls: Policy and Options for Scientific and Technical Information

    Science.gov (United States)

    2006-11-14

    National Laboratory, a Department of Energy affiliated national laboratory, in “F.A.Q. Mozart ,” at [http://www.pnl.gov/isrc / mozart /faq.html]. 2...within the scientific community....” This policy is reflected in Executive Order 12958. NSDD-189 is still in effect , as stated in a letter from the... effect increased from 4,736 in 2001 to 4,885 in 2004 (p. 5) However, it is likely that most of these were recommended by, and issued to, federal agencies

  1. The foreign policy and security options of Romania in the vision of Klaus Johannis

    Directory of Open Access Journals (Sweden)

    Radu-Ioan Opriș

    2015-03-01

    Full Text Available If a decade ago, Romania became a NATO member and it was enrolled in the accession process to the European Union, in 2014, the problem is radically different: Romania has a new status within NATO, it is part of the EU, it is in process of accession to the Schengen area and it has developed its strategic partnership with the United States of America. In this context, the aim of this paper is to bring into attention the vision of the new president of Romania, Klaus Iohannis, regarding the romanian foreign policy and security.

  2. The delusion of decoupling, and policy options for mitigating the rebound effect and the environmental impact

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen

    When analyzing environmental problems, it is useful to apply the following simple equation for the environmental impact ‘I’, (here representing energy consumption): I = P·A·T, With ‘P’ representing population, ‘A’ affluence per capita, and ‘T’ resource intensity, i.e. energy per affluence unit ‘A......’. All three factors are through the equation coupled to ‘I’, and in general we should avoid using the misleading terminology of decoupling environmental impact (energy consumption) from the economy, represented by ‘P·A’. So far essentially all policies towards lowering ‘I’ has been devoted towards...

  3. Artificial Neural Networks in Policy Research: A Current Assessment.

    Science.gov (United States)

    Woelfel, Joseph

    1993-01-01

    Suggests that artificial neural networks (ANNs) exhibit properties that promise usefulness for policy researchers. Notes that ANNs have found extensive use in areas once reserved for multivariate statistical programs such as regression and multiple classification analysis and are developing an extensive community of advocates for processing text…

  4. Artificial Neural Networks in Policy Research: A Current Assessment.

    Science.gov (United States)

    Woelfel, Joseph

    1993-01-01

    Suggests that artificial neural networks (ANNs) exhibit properties that promise usefulness for policy researchers. Notes that ANNs have found extensive use in areas once reserved for multivariate statistical programs such as regression and multiple classification analysis and are developing an extensive community of advocates for processing text…

  5. Early and School-Age Care in Santa Monica: Current System, Policy Options, and Recommendations

    Science.gov (United States)

    Pierson, Ashley; Karoly, Lynn A.; Zellman, Gail L.; Beckett, Megan K.

    2014-01-01

    The landscape of early learning and out-of-school-time programs in the City of Santa Monica is complex, with numerous providers and funding streams. This complexity reflects its evolution in response to changes in federal, state, and local priorities and initiatives. Future shifts in funding levels, program auspices, and other features are likely.…

  6. Health issues and the practicing radiologist: defining concepts and developing recommendations for leave options and policies.

    Science.gov (United States)

    Heilbrun, Marta E; Bender, Claire E; Truong, Hang B; Bluth, Edward I

    2013-09-01

    Radiologists today are faced with the challenges of maintaining and balancing individual and family health needs and the demands of the workplace. To provide the highest quality and safest care of our patients, a corresponding ethos of support for a healthy workforce is required. There is a paucity of targeted information describing protections for and maintenance of the health of the practicing radiologist, in both private and academic settings. However, a review of existing family and medical leave policies may be helpful to practice leaders and practicing radiologists as a platform for the development of strategic workforce plans. This writing, by members of the ACR Commission on Human Resources, addresses the following areas: (1) medical leave, (2) maternity and/or paternity leave, and (3) disability. Copyright © 2013 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  7. Low-income energy assistance programs: a profile of need and policy options

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-07-01

    This second report of the Fuel Oil Marketing Advisory Committee (FOMAC) of DOE is twofold: to update information on the energy needs of low-income persons and governmental response to such needs; and to emphasize the need for energy-conservation programs that may alleviate the enormous financial burden placed on low-income people by rising energy prices. FOMAC has continued to develop further and refine its initial energy-conservation recommendations. Mainly, the updated assessment document finds that the poor will expend at least 35% of their income directly on energy and will spend at least 21% of their income on household energy. Other economic impacts of rising energy costs on low-income groups are summarized. Appropriations and stipulations by Congress to aid the lo-income people are reviewed. After careful review of various program designs, FOMAC continues to support the income indexing/vendor line of credit approach. This design provides assistance to elgible households based on: energy needed, cost of fuel, and percentage of income. The cost of implementing the FOMAC design nationally would, according to estimates, range from $3.5 to $4.6 billion for the 1980-1981 winter heating season. A figure of $1.6 to $2.2 billion is being discussed in the Congress. Meeting the ongoing energy needs of the poor will require a coherent national policy which consists of aid in paying energy bills and aid in the poor's effort to conserve energy. The report seeks to promote such policies. Needs assessment, government response, FOMAC model, comments on the programs, projected cost of 1980-1981 Energy Assistance Program, need for conservation programs, and program financing are discussed.

  8. MONETARY POLICY UNDER THE IMPACT OF THE CURRENT GLOBAL CRISIS

    Directory of Open Access Journals (Sweden)

    Zina Marcu (Cioran

    2013-12-01

    Full Text Available The issue of the financial crisis draws more and more the specialists’ attention. The monetary policy has a decisive role in monitoring and reducing the inflationary phenomenon as much as possible, since it can become a real danger for an economy during a period of crisis. Inflation is a negative thing that affects the economy. It discourages the investments and the economic growth. The aim of this paper is to find the Central Bank’s economic instruments and levers that can contribute to price stability in the economy. It was found that the elaboration of a measure of monetary policy with a restrictive feature can contribute to price stability on long term, but we should take into account the macroeconomic context in which it is applied.

  9. Ensuring an optimal environment for peer education in South African schools: Goals, systems, standards and policy options for effective learning.

    Science.gov (United States)

    Swartz, Sharlene; Deutsch, Charles; Moolman, Benita; Arogundade, Emma; Isaacs, Dane; Michel, Barbara

    2016-12-01

    Peer education has long been seen as a key health promotion strategy and an important tool in preventing HIV infection. In South African schools, it is currently one of the strategies employed to do so. Based on both a recent research study of peer education across 35 schools and drawing on multiple previous studies in South Africa, this paper examines the key elements of peer education that contribute to its effectiveness and asks how this aligns with current educational and health policies. From this research, it summarises and proposes shared goals and aims, minimum standards of implementation and reflects on the necessary infrastructure required for peer education to be effective. In light of these findings, it offers policy recommendations regarding who should be doing peer education and the status peer education should have in a school's formal programme.

  10. Comparative policy analysis for alcohol and drugs: Current state of the field.

    Science.gov (United States)

    Ritter, Alison; Livingston, Michael; Chalmers, Jenny; Berends, Lynda; Reuter, Peter

    2016-05-01

    A central policy research question concerns the extent to which specific policies produce certain effects - and cross-national (or between state/province) comparisons appear to be an ideal way to answer such a question. This paper explores the current state of comparative policy analysis (CPA) with respect to alcohol and drugs policies. We created a database of journal articles published between 2010 and 2014 as the body of CPA work for analysis. We used this database of 57 articles to clarify, extract and analyse the ways in which CPA has been defined. Quantitative and qualitative analysis of the CPA methods employed, the policy areas that have been studied, and differences between alcohol CPA and drug CPA are explored. There is a lack of clear definition as to what counts as a CPA. The two criteria for a CPA (explicit study of a policy, and comparison across two or more geographic locations), exclude descriptive epidemiology and single state comparisons. With the strict definition, most CPAs were with reference to alcohol (42%), although the most common policy to be analysed was medical cannabis (23%). The vast majority of papers undertook quantitative data analysis, with a variety of advanced statistical methods. We identified five approaches to the policy specification: classification or categorical coding of policy as present or absent; the use of an index; implied policy differences; described policy difference and data-driven policy coding. Each of these has limitations, but perhaps the most common limitation was the inability for the method to account for the differences between policy-as-stated versus policy-as-implemented. There is significant diversity in CPA methods for analysis of alcohol and drugs policy, and some substantial challenges with the currently employed methods. The absence of clear boundaries to a definition of what counts as a 'comparative policy analysis' may account for the methodological plurality but also appears to stand in the way

  11. A review of the current management and treatment options for superficial venous insufficiency.

    Science.gov (United States)

    Zhan, Henry T; Bush, Ruth L

    2014-10-01

    The recognition of lower extremity venous disease as a significant cause of morbidity and lower quality of life, afflicting up to 25 % of Western populations, has led to rapid and drastic improvements in treatment options as well as an increasing awareness of the disease. Superficial venous disease, a frequent medical problem encountered in clinical practices, is now a common reason for referral to providers offering a spectrum of interventions. Venous guidelines have been set forth by the American Venous Forum and Society for Vascular Surgery covering simple spider veins to chronic venous ulcerations. (Gloviczki et al. J Vas Surg 53:2S-48S, 2011) This review provides an overview of the modern management of varicose veins and venous insufficiency.

  12. Environmental problems in the People`s Republic of China: Current magnitude and possible control options

    Energy Technology Data Exchange (ETDEWEB)

    Bhadtti, N.; Biang, C.A.; Poch, L.A.; Tompkins, M.M.

    1995-09-01

    The People`s Republic of China has been undergoing rapid economic development over the past several decades. This development has taken place with little or no attention being paid to its environmental consequences. This situation has resulted in severe contamination of the air, water, and soil resources of China, with attendant damage to human and natural populations. This report determines the major causes of air, water, and soil pollution in China and assesses their extent and magnitude. It then examines the impacts of the pollutants on various components of the human and natural environment. It identifies possible regulatory and ameliorative options available to China to deal with these pollution problems and provides information on specific strategies and the costs associated with their implementation. The objective is to shed light on China`s pollution control and remediation requirements in the near future.

  13. High-flow orbital arteriovenous malformation in a child: current management and options.

    Science.gov (United States)

    Trombly, Ryan; Sandberg, David I; Wolfe, S Anthony; Ragheb, John

    2006-07-01

    Vascular malformations of the orbit cause significant morbidity such as chronic pain, diplopia, amblyopia, and cosmetic disfigurement. They are rare lesions which require multidisciplinary care, and in the modern era results of treatment have been greatly improved with the assistance of endovascular therapy. Other treatment options include laser therapy, percutaneous embolization, open surgery, or a combination of these modalities. Nevertheless some patients suffer poor results despite modern medical advances. A case of an orbital arteriovenous malformation (AVM) initially treated independently by a dermatologist, a plastic surgeon, and a neuroendovascular interventionalist is presented. When treating patients with these rare but disabling lesions it is of the highest importance to coordinate efforts between all pertinent specialists in order to promote the best possible result.

  14. The syndrome of inappropriate antidiuretic hormone: current and future management options.

    LENUS (Irish Health Repository)

    Sherlock, Mark

    2010-06-01

    Hyponatraemia is the commonest electrolyte abnormality, and syndrome of inappropriate antidiuretic hormone (SIADH) is the most frequent underlying pathophysiology. Hyponatraemia is associated with significant morbidity and mortality, and as such appropriate treatment is essential. Treatment options for SIADH include fluid restriction, demeclocycline, urea, frusemide and saline infusion, all of which have their limitations. The introduction of the vasopressin-2 receptor antagonists has allowed clinicians to specifically target the underlying pathophysiology of SIADH. Initial studies have shown good efficacy and safety profiles in the treatment of mild to moderate hyponatraemia. However, studies assessing the efficacy and safety of these agents in acute severe symptomatic hyponatraemia are awaited. Furthermore, the cost of these agents at present may limit their use.

  15. Current and future options for the management of phantom-limb pain

    Directory of Open Access Journals (Sweden)

    Knotkova H

    2012-03-01

    Full Text Available Helena Knotkova1,2, Ricardo Cruciani1–3, Volker M Tronnier4, Dirk Rasche41Department of Pain Medicine and Palliative Care, Research Division, Institute for Non-invasive Brain Stimulation, Beth Israel Medical Center, New York, NY, USA; 2Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; 3Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, NY, USA; 4Department of Neurosurgery, University of Lübeck, GermanyAbstract: Phantom-limb pain (PLP belongs among difficult-to-treat chronic pain syndromes. Treatment options for PLP are to a large degree implicated by the level of understanding the mechanisms and nature of PLP. Research and clinical findings acknowledge the neuropathic nature of PLP and also suggest that both peripheral as well as central mechanisms, including neuroplastic changes in central nervous system, can contribute to PLP. Neuroimaging studies in PLP have indicated a relation between PLP and the neuroplastic changes. Further, it has been shown that the pathological neuroplastic changes could be reverted, and there is a parallel between an improvement (reversal of the neuroplastic changes in PLP and pain relief. These findings facilitated explorations of novel neuromodulatory treatment strategies, adding to the variety of treatment approaches in PLP. Overall, available treatment options in PLP include pharmacological treatment, supportive non-pharmacological non-invasive strategies (eg, neuromodulation using transcranial magnetic stimulation, visual feedback therapy, or motor imagery; peripheral transcutaneous electrical nerve stimulation, physical therapy, reflexology, or various psychotherapeutic approaches, and invasive treatment strategies (eg, surgical destructive procedures, nerve blocks, or invasive neuromodulation using deep brain stimulation, motor cortex stimulation, or spinal cord stimulation. Venues of further development in PLP management include a technological and

  16. Compensating the opportunity cost of forest functional zoning - two alternative options for the Romanian forest policy

    Directory of Open Access Journals (Sweden)

    Marian Drăgoi,

    2010-09-01

    Full Text Available An important challenge of the environmental policy is conceivingappropriate economic instruments able to account for the positive externalities provided by forest ecosystems. This issue is extremely important for implementing the provisions of the Romanian Forest Act, which states that forest owners shall be compensated for the opportunity costs of giving up harvesting operations due to various conservation purposes. The paper presents a statistical method based on analytical assessment of the effective forgone revenues brought about by banning the harvesting operations in 96 cases, each case being a distinctive forest management plan conceived for a large forest area, i.e. a production unit. Doing so, the scale effect has been taken into account because all legal provisions referring to forest management planning systems are focused on production units, considered the basic reference elements for sustainable forest management. The multiple regression function produced by the statistical analysis was turned into a simple formula allowing for a straightforward set up of the average compensation worth being paid per year and hectare. In order to better fetch the real opportunity cost paid for each hectare of protected forest, the algorithmwas further improved in order to account for the differences in stumpage residual value. Actually, the average compensation is differentiated onto five categories of hauling distances, using the same algorithm used by the National Forest Administration for differentiating the average reservation price established at national level on the ground of full-cost method stumpage pricing system.

  17. TRIPS, the Doha Declaration and increasing access to medicines: policy options for Ghana

    Directory of Open Access Journals (Sweden)

    Torpey K

    2005-12-01

    Full Text Available Abstract There are acute disparities in pharmaceutical access between developing and industrialized countries. Developing countries make up approximately 80% of the world's population but only represent approximately 20% of global pharmaceutical consumption. Among the many barriers to drug access are the potential consequences of the Trade Related Aspects of Intellectual Property Rights (TRIPS Agreement. Many developing countries have recently modified their patent laws to conform to the TRIPS standards, given the 2005 deadline for developing countries. Safeguards to protect public health have been incorporated into the TRIPS Agreement; however, in practice governments may be reluctant to exercise such rights given concern about the international trade and political ramifications. The Doha Declaration and the recent Decision on the Implementation of Paragraph 6 of the Doha Declaration on the TRIPS Agreement and Public Health may provide more freedom for developing countries in using these safeguards. This paper focuses on Ghana, a developing country that recently changed its patent laws to conform to TRIPS standards. We examine Ghana's patent law changes in the context of the Doha Declaration and assess their meaning for access to drugs of its population. We discuss new and existing barriers, as well as possible solutions, to provide policy-makers with lessons learned from the Ghanaian experience.

  18. Maternity waiting homes and institutional birth in Nicaragua: policy options and strategic implications.

    Science.gov (United States)

    García Prado, Ariadna; Cortez, Rafael

    2012-01-01

    With the aim of promoting institutional births and reducing the high maternal and child mortality rates in rural and poor zones, the government of Nicaragua is supporting the creation of maternity waiting homes. This study analyzes that strategy and examines the factors associated with the use of maternity waiting homes and institutional birth. To that end, we apply a quantitative approach, by means of an econometric analysis of the data extracted from surveys conducted in 2006 on a sample of women and parteras or traditional birth attendants, as well as a qualitative approach based on interviews with key informants. Results indicate that although the operation of the maternity waiting homes is usually satisfactory, there is still room for improvement along the following lines: (i) disseminating information about the homes to both women and men, as the latter frequently decide the course of women's healthcare, and to parteras, who can play an important role in referring women; (ii) strengthening the postpartum care; (iii) ensuring financial sustainability by obtaining regular financial support from the government to complement contributions from the community; and (iv) strengthening the local management and involvement of the regional government. These measures might be useful for health policy makers in Nicaragua and in other developing countries that are considering this strategy. Copyright © 2011 John Wiley & Sons, Ltd.

  19. Household demand for insecticide-treated bednets in Tanzania and policy options for increasing uptake.

    Science.gov (United States)

    Gingrich, Chris D; Hanson, Kara G; Marchant, Tanya J; Mulligan, Jo-Ann; Mponda, Hadji

    2011-03-01

    There has been considerable controversy about the most appropriate means of delivering insecticide-treated nets (ITNs) to prevent malaria. Household demand for ITNs is a key factor influencing the choice of delivery strategy, but evidence to date about price and income elasticities comes either from studies of hypothetical willingness to pay or small-scale policy experiments. This study estimates the price and income elasticities of demand for ITNs using nationally representative household survey data and actual consumer choices, in the context of a national scheme to provide vouchers for subsidized nets to pregnant women in Tanzania. Under this distribution system, the estimated price elasticity of demand for subsidized ITNs equals -0.12 and the income elasticity estimates range from zero to 0.47, depending on household socio-economic status. The model also shows a substantial decline in short-term ITN purchases for women whose household received a free ITN. These findings suggest that if the Tanzanian government continues to use a mixed public-private model to distribute ITNs, increasing the consumer subsidy alone will not dramatically improve ITN coverage. A concerted effort is required including an increase in the subsidy amount, attention to income growth for poor households, increases in women's and girls' education levels, and expansion of the retail ITN distribution network. Use of a catch-up campaign to distribute free ITNs would increase coverage but raises questions about the effect of households' long-term purchase decisions for ITNs.

  20. Policy options for the split incentive: Increasing energy efficiency for low-income renters

    Science.gov (United States)

    Bird, Stephen; Hernández, Diana

    2016-01-01

    The split incentive problem concerns the lack of appropriate incentives to implement energy efficiency measures. In particular, low income tenants face a phenomenon of energy poverty in which they allocate significantly more of their household income to energy expenditures than other renters. This problem is substantial, affecting 1.89% of all United States' energy use. If effectively addressed, it would create a range of savings between 4 and 11 billion dollars per year for many of the nation's poorest residents. We argue that a carefully designed program of incentives for participants (including landlords) in conjunction with a unique type of utility-managed on-bill financing mechanism has significant potential to solve many of the complications. We focus on three kinds of split incentives, five concerns inherent to addressing split incentive problems (scale, endurance, incentives, savings, political disfavor), and provide a detailed policy proposal designed to surpass those problems, with a particular focus on low-income tenants in a U.S. context. PMID:27053828

  1. Aviation Security: Background and Policy Options for Screening and Securing Air Cargo

    Science.gov (United States)

    2008-02-25

    Available at [http://www.ntsb.gov]. 26 See 49 CFR §1544.202. California. His only luggage was a guitar case that concealed hammers, mallets, a knife, and a...Nonetheless, commercial products using millimeter wave imaging are currently available for application in standoff scanning of a wide variety of objects...identifier technology in airport access control systems; a list of products and vendors meeting these specifications; and specific procedures for

  2. A Policy Option To Provide Sufficient Funding For Massive-Scale Sequestration of CO2

    Science.gov (United States)

    Kithil, P. W.

    2007-12-01

    Global emissions of CO2 now are nearly 30 billion tons per year, and are growing rapidly due to strong economic growth. Atmospheric levels of CO2 have reached 380 ppm and recent reports suggest the rate of increase has gone from 1% per year in the 1990's to 3% per year now - with potential to cross 550ppm in the 2020 decade. Without stabilization of atmospheric CO2 below 550ppm, climate models predict unacceptably higher average temperatures with significant risk of runaway global warming this century. While there is much talk about reducing CO2 emissions by switching to non-fossil energy sources, imposing energy efficiency, and a host of other changes, there are no new large-scale energy sources on the horizon. The options are to impose draconian cuts in fossil energy consumption that will keep us below 550ppm (devastating the global economy) - or to adopt massive-scale sequestration of CO2. Three approaches are feasible: biological ocean sequestration, geologic sequestration, and biological terrestrial sequestration. Biological sequestration is applicable to all CO2 sources, whereas geologic sequestration is limited to fossil-fuel power plants and some large point-source emitters such as cement plants and large industrial facilities. Sequestration provides a direct mechanism for reducing atmospheric levels of CO2, whereas offsetting technologies such as wind power or improved efficiency, reduce the need for more fossil fuels but do not physically remove CO2 from the environment. The primary geologic technique, carbon capture & sequestration (CCS), prevents CO2 from entering the atmosphere but likewise does not reduce existing levels of atmospheric CO2. Biological sequestration (ocean or terrestrial) physically removes CO2 from the atmosphere. Since we cannot shut down our global economy, urgent action is needed to counteract CO2 emissions, and avoid catastrophic climate change. Given the long lead time and/or small impact of offsetting energy sources

  3. United States Warship Transfers to Argentina, Brazil, and Chile: Options for U.S. Policy

    Science.gov (United States)

    1991-12-19

    interests. Another reason why this route is important to Chile is because of the possibility of increased shipping through it if the Panama canal...III.A-3 summarizes the ships removed from service during the 1980s. O1Not included in the analysis was the loss of the polar transport Bahia Paraiso in...a new aircraft carrier to replace the forty-five year old Minas Gerais. The navy also requires a cruiser, a platform they currently do not have. With

  4. 228 Empirical Analysis of Fiscal Policy Shocks and Current Account ...

    African Journals Online (AJOL)

    First Lady

    2013-01-28

    Jan 28, 2013 ... extension by Obstfeld and Rogoff, (1995) in open economy macroeconomics .... worsens the U.S. current account deficit by 47 cents by using Romer and ..... crowding-out hypothesis in Pakistan's manufacturing industry. The.

  5. Pharmacological treatment of endometriosis: review of current and new options for treatment

    Directory of Open Access Journals (Sweden)

    Maja Jakič

    2016-10-01

    Full Text Available Endometriosis is a gynecological disease that is defined as the presence of endometrium-like tissue outside the uterine cavity, and it is one of the main causes of female infertility. Although there is unfortunately no known ‘optimal’ treatment for endometriosis, there are three treatment options: medication, surgical treatment, and a combination of both. The gold standard for diagnosis of endometriosis is a diagnostic laparoscopy, which is also therapeutic. Indications for pharmacological treatment of endometriosis include empirical treatment for patients with pelvic pain who are normal on gynecological examination, or who have recurrent disease after surgical treatment or in combination with surgical treatment. In everyday practice, non-steroid anti-inflammatory drugs, oral contraceptives, and progestins per os are used as first-line pharmacological treatments of endometriosis. Gonadoliberin agonists can be used as second-line treatment, although their use is discouraged. These medications can be used alone or in combination. Studies over the last 10 years have shown that many other agents have potential for treatment of endometriosis. These can be broadly classified into several groups: anti-inflammatory agents, and agents that interfere with the hormonal system, or with other pathophysiological processes, such as a disturbed immune system, reduced apoptosis, enhanced angiogenesis, degradation of the extracellular matrix, increased oxidative stress, and epigenetic changes. However, their introduction into routine use requires more convincing clinical studies to confirm their effectiveness.

  6. Current Options for Third-Line Treatment of Metastatic Colorectal Cancer.

    Science.gov (United States)

    Grothey, Axel; Marshall, John L; Seery, Tara E

    2016-03-01

    Until recently, treatment options for patients with metastatic colorectal cancer (CRC) were limited to chemotherapy, vascular endothelial growth factor–targeted therapy, and, for patients with RAS-wild type tumors, epidermal growth factor receptor–targeted therapy. For patients with disease progression after treatment, newer agents are now available: the multitargeted tyrosine kinase inhibitor regorafenib and the cytotoxic combination of trifluridine and tipiracil (TAS-102). Both regorafenib and trifluridine/tipiracil have demonstrated significant improvements in overall survival in patients with refractory metastatic CRC. Durable responses exceeding a year have been reported with regorafenib. The agents differ in their safety profiles. Regorafenib is associated with hand-foot skin reaction and fatigue, primarily in the first cycle. Alternative dosing strategies appear to improve the tolerability of regorafenib, and randomized dosing studies are underway to define the optimal strategy. Trifluridine/tipiracil is associated primarily with myelosuppression. Sequencing of these agents can be guided by patient characteristics, such as comorbidities and adverse reactions to previous treatments. Patients with a poor performance status are not likely to benefit from regorafenib. Ongoing studies are further defining the role of regorafenib and trifluridine/tipiracil in the treatment of metastatic CRC.

  7. Translating biomonitoring data into risk management and policy implementation options for a European Network on Human Biomonitoring

    Directory of Open Access Journals (Sweden)

    Schoeters G

    2008-01-01

    will eventually lead to the formulation of a variety of policy relevant risk reduction options. Conclusion Although the usefulness of this approach still needs to be tested, and potential fine-tuning of the procedure may be necessary, approaching the policy implications of HBM in an objective framework will prove to be essential.

  8. Non-ionizing radiation protection summary of research and policy options

    CERN Document Server

    Wood, Andrew W

    2017-01-01

    This book explains the characteristics of all forms of electromagnetic non-ionizing radiation (NIR) and analyzes the relationship between exposure and its biological effects, as well as the known dose-response relationships associated with each. Taking a uniquely holistic approach to the concept of health that builds upon the WHO definition to include not only absence of disease, but the physical, mental and social well-being of individuals and the population, it reviews established and potential risks and protections, along with regulatory issues associated with each. The risks to public health of NIR, whether in the form of UV light, radio waves from wireless devices, or electric and magnetic fields associated with electrical power systems, is currently a cause of great concern among members of the public and lawmakers. But in order to separate established science from speculation and make informed decisions about how to mitigate the risks of NIR and allocate precious resources, policymakers, manufacturers...

  9. Developing Public Policy Options for Access to Drinking Water in Peripheral, Disaster and Polluted Rural Areas: A Case Study on Environment-Friendly and Conventional Technologies

    OpenAIRE

    Ruxandra Mălina Petrescu-Mag; Dacinia Crina Petrescu; Ovidiu Călin Safirescu; Mihaela Hetvary; Ioan Gheorghe Oroian; Dumitru Vâju

    2016-01-01

    Peripheral, disaster and polluted rural areas (PDP rural areas) are generally perceived as a “Cinderella” of water public policy measures, deepening the rural-urban cleavage in terms of opportunities for a decent life. The main goal of the study is to develop public policy options regarding the supply of safe drinking water in Romanian PDP rural areas. The main instrument to achieve it is an ex-ante policy analysis of three solutions: a conventional technology, based on chlorine, a green tech...

  10. Optimal management of seizures associated with tuberous sclerosis complex: current and emerging options

    Directory of Open Access Journals (Sweden)

    Wang S

    2014-10-01

    Full Text Available Shelly Wang,1 Aria Fallah2,3 1Department of Neurosurgery, University of Toronto, Toronto, ON, Canada; 2Department of Neurosurgery, Miami Children’s Hospital, Miami, FL, USA; 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Abstract: Seizures are clinically significant manifestations associated with 79%–90% of patients with tuberous sclerosis complex. Often occurring within the first year of life in the form of infantile spasms, seizures interfere with neuropsychiatric, social, and cognitive development and carry significant individual and societal consequences. Prompt identification and treatment of seizures is an important focus in the overall management of tuberous sclerosis complex patients. Medical management, either after seizure onset or prophylactically in infants with electroencephalographic abnormalities, is considered first-line therapy. Vigabatrin and adrenocorticotropic hormone have emerged over the past few decades as mainstay pharmacologic modalities. Furthermore, emerging research on mammalian target of rapamycin inhibitors demonstrated promise for the management of seizures and subependymal giant cell astrocytoma. For appropriate surgical candidates with an epileptogenic zone associated with one or more glioneuronal hamartomas, ideally in noneloquent cortex, resective surgery can be considered, which provides a cure in 56% of patients. For medically refractory patients who do not meet criteria for curative surgery, palliative surgical approaches focused on reducing seizure burden, in the form of corpus callosotomy and vagus nerve stimulation, are alternative management options. Lastly, the ketogenic diet, a reemerging therapy based on the anticonvulsant effects of ketone bodies, can be utilized independently or in conjunction with other treatment modalities for the management of difficult-to-treat seizures. Keywords: epilepsy, adrenocorticotropic hormone, vigabatrin, mammalian

  11. Current treatment options and response rates in children with chronic hepatitis C

    Institute of Scientific and Technical Information of China (English)

    Stefan Wirth

    2012-01-01

    Vertical transmission has become the most common mode of transmission of hepatitis C virus (HCV) in children. The rate of perinatal transmission from an HCVinfected mother to her child ranges from 2% to 5% and the prevalence of HCV in children in developed countries ranges between 0.1% and 0.4%. Spontaneous viral clearance seems to be dependent on the genotype and has been reported between 2.4%-25%. For chronically infected patients, treatment with recombinant polyethylene glycol (PEG)-interferon α-2b and daily ribavirin has now been approved as standard treatment for children 2-17 years of age. In five large prospective studies, a total of 318 children and adolescents aged 3-17 years were treated either with subcutaneous PEG-interferon α-2b at a dose of 1-1.5 μg/kg or 60 μg/m2 once a week in combination with oral ribavirin (15 mg/kg per day) or PEG-interferon α-2a with ribavirin. Subjects with genotype 1 and 4 received the medication for 48 wk and individuals with genotype 2 and 3 mainly for 24 wk. Overall sustained viral response (SVR) was achieved in 193/318 (60.7%) of treated patients. Stratified for genotype; 120/234 (51%) with genotype 1, 68/73 (93%) with genotype 2/3, and 6/11 (55%) with genotype 4 showed SVR. Relapse rate was between 7.7% and 17%. Overall, treatment was well tolerated; however,notable side effects were present in approximately 20%. According to recent experiences in the treatment of chronic hepatitis C in children and adolescents, a combination of PEG-interferon α with ribavirin has been found to be well tolerated and highly efficacious, particularly in individuals with genotype 2/3. Thus, this treatment can be recommended as standard of care until more effective treatment options will become available for genotype 1 patients.

  12. Advanced launcher design options for electron cyclotron current drive on ITER based on remote steering

    NARCIS (Netherlands)

    Graswinckel, M. R.; Bongers, W. A.; M.R. de Baar,; van den Berg, M. A.; Denisov, G.; Donne, A. J. H.; Elzendoorn, B. S. Q.; Goede, A. P. H.; Heidinger, R.; Kuzikov, S.; Kruijt, O. G.; Kruizinga, B.; Moro, A.; Poli, E.; Ronden, D. M. S.; Saibene, G.; Thoen, D. J.; Verhoeven, A. G. A.

    2008-01-01

    Electron cyclotron current drive will become the main scheme on ITER for the stabilization of neoclassical tearing modes (NTMs) and the control of sawtooth oscillations. The effectiveness of this scheme forms the basis for the requirements of the ITER Upper Port Launcher. These requirements include

  13. Current Sino-Latin American Relations and the Corresponding Policies

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Ⅰ. History of the Relationship and Its Current Situation. The Sino-Latin American relationship has a long-standing history that starts from the trade exchanges in the middle of the 16th century.From the 18th century to the early 19th century,hundreds and thousands of Chinese laborers were seized and sold by the western colonists to Latin America as "coolies" who made contribution to the local economic development there.

  14. Are current debt relief initiatives an option for scaling up health financing in beneficiary countries?

    Science.gov (United States)

    Kaddar, M; Furrer, E

    2008-11-01

    One central goal of the enhanced Heavily Indebted Poor Countries (HIPC) Initiative and the more recent Multilateral Debt Relief Initiative (MDRI) is to free up additional resources for public spending on poverty reduction. The health sector was expected to benefit from a considerable share of these funds. The volume of released resources is important enough in certain countries to make a difference for priority programmes that have been underfunded so far. However, the relevance of these initiatives in terms of boosting health expenditure depends essentially, at the global level, on the compliance of donors with their aid commitments and, at the domestic level, on the success of health officials in advocating for an adequate share of the additional fiscal space. Advocacy efforts are often limited by a state of asymmetric information whereby some ministries are not well aware of the economic consequences of debt relief on public finances and of the management systems in place to deal with savings from debt relief. A thorough comprehension of these issues seems essential for health advocates to increase their bargaining power and for a wider public to readjust expectations of what debt relief can realistically achieve and of what can be measured. This paper intends to narrow the information gap by classifying debt relief savings management systems observed in practice. We illustrate some of the major advantages and stated drawbacks and outline the policy implications for health officials operating in the countries concerned. There should be careful monitoring of fungibility (i.e. where untraceable funds risk substitution) and additionality (i.e. the extent to which new inputs add to existing inputs at national and international level).

  15. Current treatment options for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

    Science.gov (United States)

    Beaton, Melanie D

    2012-06-01

    Nonalcoholic fatty liver disease is the leading cause of liver disease in western society. It is a cause of end-stage liver disease, with increased mortality secondary to cirrhosis and its complications. It is also recognized that cardiovascular disease is a significant cause of death in these patients. Significant work evaluating various treatments has been performed in recent years; however, to date, no ideal therapy exists. Lifestyle modification remains the cornerstone of management. The present article reviews the current status of various treatment modalities evaluated in nonalcoholic fatty liver disease.

  16. Viewpoint – Swimming against the Current: Questioning Development Policy and Practice

    Directory of Open Access Journals (Sweden)

    Kurt Mørck Jensen

    2013-06-01

    Full Text Available The water world is dominated by normative policies prescribing what 'good development' is all about. It is a universe of its own where policies live their own lives and feed in and out of each other. As new buzzwords continue to be invented or reinvented, policies continue to maintain their shiny images of how water resources or water supply should be managed. There are many water professionals acting as missionaries in the service of policies but probably fewer professionals acting up against blindfolded policy promotion. It is when water policies are being implemented in the real world that the trouble starts. In spite of their well-intended mission, water policies often suffer shipwreck on the socio-economic and political realities in developing countries. Through cases from India and the Mekong, the author demonstrates what happens when normative water polices are forced out of their comfort zone and into social and political realities. Although policies are made of stubborn material they need to be questioned through continuous analytical insight into developing country realities. But undertaking critical analysis and questioning the wisdom of water policies are easier said than done. It takes a lot of effort to swim against the policy current.

  17. Stem Cell Transplantation for Peripheral Nerve Regeneration: Current Options and Opportunities

    Directory of Open Access Journals (Sweden)

    Liangfu Jiang

    2017-01-01

    Full Text Available Peripheral nerve regeneration is a complicated process highlighted by Wallerian degeneration, axonal sprouting, and remyelination. Schwann cells play an integral role in multiple facets of nerve regeneration but obtaining Schwann cells for cell-based therapy is limited by the invasive nature of harvesting and donor site morbidity. Stem cell transplantation for peripheral nerve regeneration offers an alternative cell-based therapy with several regenerative benefits. Stem cells have the potential to differentiate into Schwann-like cells that recruit macrophages for removal of cellular debris. They also can secrete neurotrophic factors to promote axonal growth, and remyelination. Currently, various types of stem cell sources are being investigated for their application to peripheral nerve regeneration. This review highlights studies involving the stem cell types, the mechanisms of their action, methods of delivery to the injury site, and relevant pre-clinical or clinical data. The purpose of this article is to review the current point of view on the application of stem cell based strategy for peripheral nerve regeneration.

  18. Targeting Bone Metabolism in Patients with Advanced Prostate Cancer: Current Options and Controversies

    Directory of Open Access Journals (Sweden)

    Tilman Todenhöfer

    2015-01-01

    Full Text Available Maintaining bone health remains a clinical challenge in patients with prostate cancer (PC who are at risk of developing metastatic bone disease and increased bone loss due to hormone ablation therapy. In patients with cancer-treatment induced bone loss (CTIBL, antiresorptive agents have been shown to improve bone mineral density (BMD and to reduce the risk of fractures. For patients with bone metastases, both zoledronic acid and denosumab delay skeletal related events (SREs in the castration resistant stage of disease. Novel agents targeting the Wnt inhibitors dickkopf-1 and sclerostin are currently under investigation for the treatment of osteoporosis and malignant bone disease. New antineoplastic drugs such as abiraterone, enzalutamide, and Radium-223 are capable of further delaying SREs in patients with advanced PC. The benefit of antiresorptive treatment for patients with castration sensitive PC appears to be limited. Recent trials on the use of zoledronic acid for the prevention of bone metastases failed to be successful, whereas denosumab delayed the occurrence of bone metastases by a median of 4.1 months. Currently, the use of antiresorptive drugs to prevent bone metastases still remains a field of controversies and further trials are needed to identify patient subgroups that may profit from early therapy.

  19. Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis.

    Science.gov (United States)

    Bachert, Claus; Zhang, Luo; Gevaert, Phillippe

    2015-12-01

    Chronic rhinosinusitis (CRS) affects more than 10% of the population in the United States and Europe. Recent findings point to a considerable variation of inflammatory subtypes in patients with CRS with nasal polyps and patients with CRS without nasal polyps. According to current guidelines, glucocorticosteroids and antibiotics are the principle pharmacotherapeutic approaches; however, they fail in a group of patients who share common clinical and laboratory markers. Several clinical phenotypes often leading to uncontrolled disease, including adult nasal polyposis, aspirin-exacerbated respiratory disease, and allergic fungal rhinosinusitis, are characterized by a common endotype: a TH2 bias is associated with a higher likelihood of comorbid asthma and recurrence after surgical treatment. As a consequence, several innovative approaches targeting the TH2 bias with humanized mAbs have been subjected to proof-of-concept studies in patients with CRS with nasal polyps with or without comorbid asthma: omalizumab, reslizumab, mepolizumab, and recently dupilumab. Future concepts using upstream targets, such as GATA-3, also focus on this endotype. This current development might result in advantages in the treatment of patients with the most severe CRS.

  20. Managing Behçet’s disease: An update on current and emerging treatment options

    Directory of Open Access Journals (Sweden)

    P LA van Daele

    2009-05-01

    Full Text Available P LA van Daele, J H Kappen, P M van Hagen, J AM van LaarDepartment of Internal Medicine, Department of Immunology, Erasmus MC, ‘s Gravendijkwal 230, 3015 Ce Rotterdam, The NetherlandsAbstract: Behçet’s disease is an autoinflammatory vasculitis of unknown origin characterized by recurrent oral and genital ulcers, uveitis, arthritis and skin lesions. Additionally, involvement of the gastrointestinal tract, central nervous system and large vessels may occur. The disease is prevalent in countries along the ancient Silk Road from Eastern Asia to the Mediterranean Basin. Many treatment modalities are currently available. The choice of treatment depends on organ involvement and severity of disease. Topical treatment with corticosteroids is often sufficient for mucocutaneous involvement, however for more severe disease with vasculitis or neurological involvement a more aggressive approach is warranted. Newer drugs (biologicals influencing cytokines and thereby T-cell function are promising with an acceptable side effect profile. Unfortunately, reimbursement of the costs of biologicals for rare disease is still a problem in various countries. In this report we discuss the current treatment modalities for Behçet’s disease.Keywords: Behçet’s disease, biologicals, treatment

  1. Stem Cell Transplantation for Peripheral Nerve Regeneration: Current Options and Opportunities.

    Science.gov (United States)

    Jiang, Liangfu; Jones, Salazar; Jia, Xiaofeng

    2017-01-05

    Peripheral nerve regeneration is a complicated process highlighted by Wallerian degeneration, axonal sprouting, and remyelination. Schwann cells play an integral role in multiple facets of nerve regeneration but obtaining Schwann cells for cell-based therapy is limited by the invasive nature of harvesting and donor site morbidity. Stem cell transplantation for peripheral nerve regeneration offers an alternative cell-based therapy with several regenerative benefits. Stem cells have the potential to differentiate into Schwann-like cells that recruit macrophages for removal of cellular debris. They also can secrete neurotrophic factors to promote axonal growth, and remyelination. Currently, various types of stem cell sources are being investigated for their application to peripheral nerve regeneration. This review highlights studies involving the stem cell types, the mechanisms of their action, methods of delivery to the injury site, and relevant pre-clinical or clinical data. The purpose of this article is to review the current point of view on the application of stem cell based strategy for peripheral nerve regeneration.

  2. Current anti-doping policy: a critical appraisal

    Directory of Open Access Journals (Sweden)

    Mauron Alexandre

    2007-03-01

    Full Text Available Abstract Background Current anti-doping in competitive sports is advocated for reasons of fair-play and concern for the athlete's health. With the inception of the World Anti Doping Agency (WADA, anti-doping effort has been considerably intensified. Resources invested in anti-doping are rising steeply and increasingly involve public funding. Most of the effort concerns elite athletes with much less impact on amateur sports and the general public. Discussion We review this recent development of increasingly severe anti-doping control measures and find them based on questionable ethical grounds. The ethical foundation of the war on doping consists of largely unsubstantiated assumptions about fairness in sports and the concept of a "level playing field". Moreover, it relies on dubious claims about the protection of an athlete's health and the value of the essentialist view that sports achievements reflect natural capacities. In addition, costly antidoping efforts in elite competitive sports concern only a small fraction of the population. From a public health perspective this is problematic since the high prevalence of uncontrolled, medically unsupervised doping practiced in amateur sports and doping-like behaviour in the general population (substance use for performance enhancement outside sport exposes greater numbers of people to potential harm. In addition, anti-doping has pushed doping and doping-like behaviour underground, thus fostering dangerous practices such as sharing needles for injection. Finally, we argue that the involvement of the medical profession in doping and anti-doping challenges the principles of non-maleficience and of privacy protection. As such, current anti-doping measures potentially introduce problems of greater impact than are solved, and place physicians working with athletes or in anti-doping settings in an ethically difficult position. In response, we argue on behalf of enhancement practices in sports within a

  3. Current anti-doping policy: a critical appraisal.

    Science.gov (United States)

    Kayser, Bengt; Mauron, Alexandre; Miah, Andy

    2007-03-29

    Current anti-doping in competitive sports is advocated for reasons of fair-play and concern for the athlete's health. With the inception of the World Anti Doping Agency (WADA), anti-doping effort has been considerably intensified. Resources invested in anti-doping are rising steeply and increasingly involve public funding. Most of the effort concerns elite athletes with much less impact on amateur sports and the general public. We review this recent development of increasingly severe anti-doping control measures and find them based on questionable ethical grounds. The ethical foundation of the war on doping consists of largely unsubstantiated assumptions about fairness in sports and the concept of a "level playing field". Moreover, it relies on dubious claims about the protection of an athlete's health and the value of the essentialist view that sports achievements reflect natural capacities. In addition, costly antidoping efforts in elite competitive sports concern only a small fraction of the population. From a public health perspective this is problematic since the high prevalence of uncontrolled, medically unsupervised doping practiced in amateur sports and doping-like behaviour in the general population (substance use for performance enhancement outside sport) exposes greater numbers of people to potential harm. In addition, anti-doping has pushed doping and doping-like behaviour underground, thus fostering dangerous practices such as sharing needles for injection. Finally, we argue that the involvement of the medical profession in doping and anti-doping challenges the principles of non-maleficience and of privacy protection. As such, current anti-doping measures potentially introduce problems of greater impact than are solved, and place physicians working with athletes or in anti-doping settings in an ethically difficult position. In response, we argue on behalf of enhancement practices in sports within a framework of medical supervision. Current anti

  4. Chronic maladaptive pain in cats: A review of current and future drug treatment options.

    Science.gov (United States)

    Adrian, Derek; Papich, Mark; Baynes, Ron; Murrell, Jo; Lascelles, B Duncan X

    2017-08-20

    Despite our increasing understanding of the pathophysiology underlying chronic or maladaptive pain, there is a significant gap in our ability to diagnose and treat the condition in domestic cats. Newer techniques being used to identify abnormalities in pain processing in the cat include validated owner questionnaires, measurement of movement and activity, and measurement of sensory thresholds and somatomotor responses. While some data are available evaluating possible therapeutics for the treatment of chronic pain in the cat, most data are limited to normal cats. This review details our current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Detection of mild inherited disorders of blood coagulation: current options and personal recommendations.

    Science.gov (United States)

    Lippi, Giuseppe; Pasalic, Leonardo; Favaloro, Emmanuel J

    2015-08-01

    Although assessment of prior personal and familial bleeding history is an important aspect of the diagnosis of bleeding disorders, patients with mild inherited bleeding disorders are sometimes clinically asymptomatic until presented with a hemostatic challenge. However, bleeding may occur after incursion of trauma or surgery, so detection of these conditions reflects an important facet of clinical and laboratory practice. Mild bleeding disorders may be detected as a result of family studies or following identification of abnormal values in first-line screening tests such as activated partial thromboplastin time, prothrombin time, fibrinogen and global platelet function screen testing, such as the platelet function analyzer. Following determination of abnormal screening tests, subsequent investigation should follow a systematic approach that targets specific diagnostic tests, and including factor assays, full platelet function assays and more extensive specialized hemostasis testing. The current report provides a personal overview on inherited disorders of blood coagulation and their detection.

  6. Current status and future options for trauma and emergency surgery in Europe.

    Science.gov (United States)

    Leppaniemi, Ari

    2008-01-01

    Currently, there is great variation in the way trauma and non-trauma emergency surgery is organized in Europe. Trauma system development based on orthopedic trauma surgery seems to be more advanced in the central European countries and less developed in Scandinavia, The Baltic States, United Kingdom and the Mediterranean countries. Specific training for trauma surgery correlates with higher level of trauma system development. Multiple common features in the management of a surgical emergency, whether caused by injury or acute disease process, would favor the integration of these two disciplines into a single organizational and educational entity based on regionalization of emergency surgical services and general surgery-based education aiming for multidisciplinary team leadership and decision making skills, and surgical competence in acute life- and limb-saving surgery.

  7. An overview of current NAMA guidance. Policy Brief

    Energy Technology Data Exchange (ETDEWEB)

    Cameron, L.R. [ECN Policy Studies, Amsterdam (Netherlands)

    2013-05-15

    The International Climate Initiative formed a number of working groups within an Enhanced NAMA Cooperation Group. The Tools and Guides working group seeks to coordinate current efforts on NAMA related tools, guidebooks and templates, as well as reduce repetition of such work by different organisations. As a first step towards this goal, this brief analysis looks at the 8 main guides on NAMA development that have been published, or made available in draft form, as of May 2013. This note summarises the approach found in these guides and identifies a number of areas, or gaps, that would benefit from further effort to provide supporting resources and guidance. It also aims to provide the basis for further discussion within the working group.

  8. The Evolution of Cardiovascular Surgery in Elderly Patient: A Review of Current Options and Outcomes

    Directory of Open Access Journals (Sweden)

    Francesco Nicolini

    2014-01-01

    Full Text Available Due to the increase in average life expectancy and the higher incidence of cardiovascular disease with advancing age, more elderly patients present for cardiac surgery nowadays. Advances in pre- and postoperative care have led to the possibility that an increasing number of elderly patients can be operated on safely and with a satisfactory outcome. Currently, coronary artery bypass surgery, aortic and mitral valve surgery, and major surgery of the aorta are performed in elderly patients. The data available show that most cardiac surgical procedures can be performed in elderly patients with a satisfactory outcome. Nevertheless, the risk for these patients is only acceptable in the absence of comorbidities. In particular, renal dysfunction, cerebrovascular disease, and poor clinical state are associated with a worse outcome in elderly patients. Careful patient selection, flawless surgery, meticulous hemostasis, perfect anesthesia, and adequate myocardial protection are basic requirements for the success of cardiac surgery in elderly patients. The care of elderly cardiac surgical patients can be improved only through the strict collaboration of geriatricians, anesthesiologists, cardiologists, and cardiac surgeons, in order to obtain a tailored treatment for each individual patient.

  9. Management of menopause-associated vasomotor symptoms: Current treatment options, challenges and future directions

    Directory of Open Access Journals (Sweden)

    Deirdre R Pachman

    2010-05-01

    Full Text Available Deirdre R Pachman1, Jason M Jones1, Charles L Loprinzi21Internal Medicine, Mayo Clinic, Rochester, MN, USA; 2Medical Oncology, Mayo Clinic, Rochester, MN, USAAbstract: Hot flashes are one of the most common and distressing symptoms associated with menopause, occurring in more than 75% of postmenopausal women. They are especially problematic in breast cancer patients since some breast cancer therapies can induce hot flashes. For mild hot flashes, it is proposed that behavioral modifications are the first step in management. Hormonal therapies, including estrogens and progestogens, are the most well known effective agents in relieving hot flashes; however, the safety of these agents is controversial. There is an increasing amount of literature on nonhormonal agents for the treatment of hot flashes. The most promising data regard newer antidepressant agents such as venlafaxine, which reduces hot flashes by about 60%. Gabapentin is another nonhormonal agent that is effective in reducing hot flashes. While many complimentary therapies, including phytoestrogens, black cohosh, and dehydroepiandrosterone, have been explored for the treatment of hot flashes; none can be recommended at this time. Furthermore, there is a lack of strong evidence to support exercise, yoga, or relaxation for the treatment of hot flashes. Paced respirations and hypnosis appear to be promising enough to warrant further investigation. Another promising nonpharmacological therapy, currently under investigation, involves a stellate ganglion block.Keywords: vasomotor symptoms, hot flashes, menopause, therapy

  10. Current options for the treatment of Paget’s disease of the bone

    Directory of Open Access Journals (Sweden)

    Daniela Merlotti

    2009-07-01

    Full Text Available Daniela Merlotti, Luigi Gennari, Giuseppe Martini, Ranuccio NutiDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Siena, ItalyAbstract: Paget’s disease of bone (PDB is a chronic bone remodeling disorder characterized by increased osteoclast-mediated bone resorption, with subsequent compensatory increases in new bone formation, resulting in a disorganized mosaic of woven and lamellar bone at affected skeletal sites. This disease is most often asymptomatic but can be associated with bone pain or deformity, fractures, secondary arthritis, neurological complications, deafness, contributing to substantial morbidity and reduced quality of life. Neoplastic degeneration of pagetic bone is a relatively rare event, occurring with an incidence of less than 1%, but has a grave prognosis. Specific therapy for PDB is aimed at decreasing the abnormal bone turnover and bisphosphonates are currently considered the treatment of choice. These treatments are associated with a reduction in plasma alkaline phosphatase (ALP activity and an improvement in radiological and scintigraphic appearance and with a reduction in bone pain and bone deformity, Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this debilitating disorder.Keywords: Paget’s disease of bone, bisphosphonates, aminobisphosphonates, bone remodeling

  11. Clinical roundtable monograph. Current treatment options for metastatic breast cancer: what now?

    Science.gov (United States)

    Rugo, Hope S; O'Shaughnessy, Joyce A; Perez, Edith A

    2011-11-01

    Approximately 30% of patients with breast cancer will develop metastatic breast disease. Metastatic breast cancer is considered an incurable disease, with complete remission rarely achieved after treatment. The goal of treatment for metastatic breast cancer patients is to increase overall survival time and delay disease progression while ameliorating symptoms and improving or maintaining quality of life. Single-agent therapeutic regimens are appropriate for most metastatic breast cancer patients. Patients with the luminal A subtype of breast cancer, which is more indolent in nature and tends to be more sensitive to treatment in general, often respond well to single-agent therapy. Several chemotherapy regimens are recommended for the treatment of metastatic breast cancer. Compared with single-agent regimens, these combination regimens often produce a greater improvement in the rate of objective response as well as a prolongation of progression-free survival. There is little evidence, however, of improvement in overall survival. Combination chemotherapy regimens are often associated with a greater degree of toxicity depending on schedules and doses used. The use of bevacizumab in metastatic breast cancer is currently a topic of controversy. It is hoped that forthcoming trial data will enable the identification of a group of patients, based on tumor biology, who could benefit from bevacizumab-based therapy.

  12. Oral antiplatelet therapy for atherothrombotic disease: overview of current and emerging treatment options

    Science.gov (United States)

    Fintel, Dan J

    2012-01-01

    Clinical presentations of atherothrombotic vascular disease, such as acute coronary syndromes, ischemic stroke or transient ischemic attack, and symptomatic peripheral arterial disease, are major causes of morbidity and mortality worldwide. Platelet activation and aggregation play a seminal role in the arterial thrombus formation that precipitates acute manifestations of atherothrombotic disease. As a result, antiplatelet therapy has become the cornerstone of therapy for the prevention and treatment of atherothrombotic disease. Dual antiplatelet therapy with aspirin and a P2Y12 adenosine diphosphate (ADP) receptor inhibitor, such as clopidogrel or prasugrel, is the current standard-of-care antiplatelet therapy in patients with acute coronary syndromes managed with an early invasive strategy. However, these agents are associated with several important clinical limitations, including significant residual risk for ischemic events, bleeding risk, and variability in the degree of platelet inhibition. The residual risk can be attributed to the fact that aspirin and P2Y12 inhibitors block only the thromboxane A2 and ADP platelet activation pathways but do not affect the other pathways that lead to thrombosis, such as the protease-activated receptor-1 pathway stimulated by thrombin, the most potent platelet agonist. Bleeding risk associated with aspirin and P2Y12 inhibitors can be explained by their inhibitory effects on the thromboxane A2 and ADP pathways, which are critical for protective hemostasis. Interpatient variability in the degree of platelet inhibition in response to antiplatelet therapy may have a genetic component and contribute to poor clinical outcomes. These considerations underscore the clinical need for therapies with a novel mechanism of action that may reduce ischemic events without increasing the bleeding risk. PMID:22393298

  13. Systemic and localized scleroderma in children: current and future treatment options.

    Science.gov (United States)

    Rosenkranz, Margalit E; Agle, Lucila M A; Efthimiou, Petros; Lehman, Thomas J A

    2006-01-01

    Scleroderma is a group of rare and complex diseases with varied clinical manifestations. The most obvious manifestation of the diseases is skin hardening and sclerosis. Scleroderma can be divided into two main subgroups: systemic and localized. The systemic form, also known as systemic sclerosis, involves diffuse skin involvement and potentially severe visceral involvement. Localized scleroderma on the other hand is more common in children and usually confined to a specific region of the body with no internal organ involvement. The juvenile forms of systemic sclerosis and localized scleroderma are important conditions in children because of the clinical severity and substantial mortality of systemic scleroderma and the major growth defects associated with childhood-onset localized disease even if the active disease itself is self-limited. The pathogenic pathways of the various forms of scleroderma are only partially defined, but the main defect in scleroderma is abnormal collagen deposition leading to eventual fibrosis in the skin as well as multiple organ systems such as the heart and lungs in juvenile systemic sclerosis. Therapeutics are divided into three main subgroups for systemic sclerosis: antifibrotics, anti-inflammatories, and vasodilators. For localized disease, anti-inflammatories, vitamin D analogs, and UV irradiation have been investigated. However, the infrequency of scleroderma in the pediatric population plus the fact that this disease is very often self-limiting makes randomized controlled trials very difficult. It is for this reason that most data on treatment modalities for this disease have been extrapolated from studies in adult patients. There is no one therapy for systemic sclerosis or localized scleroderma that has proven to be very effective or significantly disease modifying. However, current therapeutic strategies must be initiated early in the disease course for maximum beneficial clinical effects. New interventions such as autologous

  14. Oral antiplatelet therapy for atherothrombotic disease: overview of current and emerging treatment options

    Directory of Open Access Journals (Sweden)

    Fintel DJ

    2012-02-01

    Full Text Available Dan J FintelBluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, USAAbstract: Clinical presentations of atherothrombotic vascular disease, such as acute coronary syndromes, ischemic stroke or transient ischemic attack, and symptomatic peripheral arterial disease, are major causes of morbidity and mortality worldwide. Platelet activation and aggregation play a seminal role in the arterial thrombus formation that precipitates acute manifestations of atherothrombotic disease. As a result, antiplatelet therapy has become the cornerstone of therapy for the prevention and treatment of atherothrombotic disease. Dual antiplatelet therapy with aspirin and a P2Y12 adenosine diphosphate (ADP receptor inhibitor, such as clopidogrel or prasugrel, is the current standard-of-care antiplatelet therapy in patients with acute coronary syndromes managed with an early invasive strategy. However, these agents are associated with several important clinical limitations, including significant residual risk for ischemic events, bleeding risk, and variability in the degree of platelet inhibition. The residual risk can be attributed to the fact that aspirin and P2Y12 inhibitors block only the thromboxane A2 and ADP platelet activation pathways but do not affect the other pathways that lead to thrombosis, such as the protease-activated receptor-1 pathway stimulated by thrombin, the most potent platelet agonist. Bleeding risk associated with aspirin and P2Y12 inhibitors can be explained by their inhibitory effects on the thromboxane A2 and ADP pathways, which are critical for protective hemostasis. Interpatient variability in the degree of platelet inhibition in response to antiplatelet therapy may have a genetic component and contribute to poor clinical outcomes. These considerations underscore the clinical need for therapies with a novel mechanism of action that may reduce ischemic events without increasing the bleeding risk

  15. Epidemiology and Pathogenesis of C. difficile and MRSA in the Light of Current NHS Control Policies: A Policy review.

    Science.gov (United States)

    Agha, Maliha

    2012-01-01

    Healthcare associated infections (HCAIs) cause significant morbidity and mortality, and are estimated to cost the United Kingdom National Health Service £1 billion annually. The current health care infection rates suggest that the level of performance to avoid HCAIs is not maintained consistently. Increasing screening, improving local accountability and performance management, careful use of antibiotics in the management of emergency patients, health economy wide approaches, and improved hand washing will be effective in lowering the rate of HCAIs. This paper reviews current NHS Control Policies in place for Methicillin Resistant Staphylococcus Aureus (MRSA) and C. difficile.

  16. Perspective: Improving nutritional guidelines for sustainable health policies: Current status and perspectives

    DEFF Research Database (Denmark)

    Magni, Paolo; Bier, Dennis M; Pecorelli, Sergio

    2017-01-01

    application of these concepts requires the translation of scientific information into practical approaches that have a tangible and measurable impact at both individual and population levels. The agenda for the future is expected to support available methodology in nutrition research to personalize guideline...... a constructive coalition among scientists, policy makers, and communication professionals for sustainable health and nutritional policies. Currently, a strong rationale and available data support a personalized dietary approach according to personal variables, including sex and age, circulating metabolic...

  17. Encouraging private sector investment in climatefriendly technologies in developing countries. An assessment of policy options for the Dutch government

    Energy Technology Data Exchange (ETDEWEB)

    Van Rooijen, S.N.M.; Van Wees, M.T. [Capacity for Sustainable Development CAP SD, Amersfoort (Netherlands)

    2006-10-15

    This study aims to explore new or reformed policies to be adopted by the Dutch government to encourage private sector investments in climate-friendly technologies in developing countries. A literature review of barriers to climate-friendly investments and of directions for solutions has been complemented with a number of in-depth interviews with stakeholders representing the major actors involved in investment projects (project sponsors, financing institutions, institutional investors and government). The barrier analysis has resulted in the following list of key obstacles to climate-friendly investments: (1) Lack of a sound, transparent and stable enabling environment for investing in developing countries; (2) Shortage of experienced and creditworthy sponsors; (3) High specific project risks; (4) Overestimation investment risks related to (sustainable) investments in developing countries in general (risk perspective); (5) Additional costs of climate-friendly technologies; (6) Shortage of risk capital; (7) Insufficient guarantee mechanisms; (8) Lack of know-how on public-private partnership structures and on financial design; and (9) Lack of insight how corporate social responsibility can be operationalised. Four main gaps have been identified on the basis of an assessment of current Dutch policies and instruments: (1) Shortage of instruments to directly promote investments; (2) Underdeveloped guarantee instruments; (3) Too restrictive cap on project size in financial schemes; (4) Lack of support in operationalising the concept of corporate social responsibility. Four areas for new or intensified policies have been identified based on the barrier and gap analysis: (1) Direct promotion of (potentially large scale) investments, including: (a) Supporting (the establishment of) sponsor companies developing sustainable energy projects in developing countries; (b) Making risk capital available; (c) Creating investment credit facilities; (d) Making development capital in

  18. Vietnam's energy sector: A review of current energy policies and strategies

    Energy Technology Data Exchange (ETDEWEB)

    Tien Minh Do, E-mail: tmdo@eng.uts.edu.au [Hanoi University of Science and Technology (HUST), 1 Dai Co Viet Street, Hai Ba Trung District, Hanoi (Viet Nam); Sharma, Deepak [University of Technology, Sydney (UTS), Broadway, Ultimo, NSW 2007 (Australia)

    2011-10-15

    Since the introduction of market-oriented economy in 1986, Vietnam has made noticeable socio-economic progress. In this progress, the energy sector has played a vital role. This role is likely to deepen in the years to come as Vietnam strives to achieve even higher levels in economic progress. Such deepening in the role of energy, this paper argues, will heighten concerns about the security of energy supply, and economic, environmental, social and political consequences. In order to address these issues, Vietnam has over the last decade, developed a suite of energy policies. A deeper review of these policies suggests that they are typified by economic-growth orientation, exclusive focus on a single-sector or single issue, and largely neglect the significance of cross-sectoral and cross-thematic issues arising from the interdependencies between energy, economy, and the polity at large. The existing energy policy settings are, therefore, unlikely to be able to provide a satisfactory redress to the challenges noted above. This paper provides an overview of the current energy policies with a view to identify areas where further policy effort is needed in order to facilitate a sustainable development of the Vietnamese energy sector. - Highlights: > Identifying challenges faced by the Vietnamese energy sector. > Analyzing limitations of the existing energy policy settings (policies, strategies and institutions) in addressing these challenges. > Developing recommendations on improving the existing energy policy settings to provide a satisfactory redress for the challenges noted above.

  19. Options Study - Phase II

    Energy Technology Data Exchange (ETDEWEB)

    R. Wigeland; T. Taiwo; M. Todosow; W. Halsey; J. Gehin

    2010-09-01

    The Options Study has been conducted for the purpose of evaluating the potential of alternative integrated nuclear fuel cycle options to favorably address the issues associated with a continuing or expanding use of nuclear power in the United States. The study produced information that can be used to inform decisions identifying potential directions for research and development on such fuel cycle options. An integrated nuclear fuel cycle option is defined in this study as including all aspects of the entire nuclear fuel cycle, from obtaining natural resources for fuel to the ultimate disposal of used nuclear fuel (UNF) or radioactive wastes. Issues such as nuclear waste management, especially the increasing inventory of used nuclear fuel, the current uncertainty about used fuel disposal, and the risk of nuclear weapons proliferation have contributed to the reluctance to expand the use of nuclear power, even though it is recognized that nuclear power is a safe and reliable method of producing electricity. In this Options Study, current, evolutionary, and revolutionary nuclear energy options were all considered, including the use of uranium and thorium, and both once-through and recycle approaches. Available information has been collected and reviewed in order to evaluate the ability of an option to clearly address the challenges associated with the current implementation and potential expansion of commercial nuclear power in the United States. This Options Study is a comprehensive consideration and review of fuel cycle and technology options, including those for disposal, and is not constrained by any limitations that may be imposed by economics, technical maturity, past policy, or speculated future conditions. This Phase II report is intended to be used in conjunction with the Phase I report, and much information in that report is not repeated here, although some information has been updated to reflect recent developments. The focus in this Options Study was to

  20. The healthy options for nutrition environments in schools (Healthy ONES group randomized trial: using implementation models to change nutrition policy and environments in low income schools

    Directory of Open Access Journals (Sweden)

    Coleman Karen J

    2012-06-01

    Full Text Available Abstract Background The Healthy Options for Nutrition Environments in Schools (Healthy ONES study was an evidence-based public health (EBPH randomized group trial that adapted the Institute for Healthcare Improvement’s (IHI rapid improvement process model to implement school nutrition policy and environmental change. Methods A low-income school district volunteered for participation in the study. All schools in the district agreed to participate (elementary = 6, middle school = 2 and were randomly assigned within school type to intervention (n = 4 and control (n =4 conditions following a baseline environmental audit year. Intervention goals were to 1 eliminate unhealthy foods and beverages on campus, 2 develop nutrition services as the main source on campus for healthful eating (HE, and 3 promote school staff modeling of HE. Schools were followed across a baseline year and two intervention years. Longitudinal assessment of height and weight was conducted with second, third, and sixth grade children. Behavioral observation of the nutrition environment was used to index the amount of outside foods and beverages on campuses. Observations were made monthly in each targeted school environment and findings were presented as items per child per week. Results From an eligible 827 second, third, and sixth grade students, baseline height and weight were collected for 444 second and third grade and 135 sixth grade students (51% reach. Data were available for 73% of these enrolled students at the end of three years. Intervention school outside food and beverage items per child per week decreased over time and control school outside food and beverage items increased over time. The effects were especially pronounced for unhealthy foods and beverage items. Changes in rates of obesity for intervention school (28% baseline, 27% year 1, 30% year 2 were similar to those seen for control school (22% baseline, 22% year 1, 25% year 2 children

  1. Mars ISRU for Production of Mission Critical Consumables - Options, Recent Studies, and Current State of the Art

    Science.gov (United States)

    Sanders, G. B.; Paz, A.; Oryshchyn, L.; Araghi, K.; Muscatello, A.; Linne, D.; Kleinhenz, J.; Peters, T.

    2015-01-01

    with Mars ISRU systems further substantiated the preliminary results from the Mars DRA 5.0 study. This paper will provide an overview of Mars ISRU consumable production options, the analyses, results, and conclusions from the Mars DRA 5.0 (2007), Mars Collaborative (2013), and Mars ISRU Payload for the Supersonic Retro Propulsion (2014) mission studies, and the current state-of-the-art of Mars ISRU technologies and systems. The paper will also briefly discuss the mission architectural implications associated with Mars resource and ISRU processing options.

  2. Education and the energy crisis: policies and actions for the Department of Energy. [Options and alternatives, DOE Education Programs Div

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-01-22

    This report is the result of a study carried out to determine options and alternatives for the Education Programs Division (EPD) of the Department of Energy. In the conduct of this study, numerous individuals from various concerned institutions were interviewed. While the project scope clearly precluded contact with every involved or potentially involved party, a concerted effort was made to obtain a representative sampling of the opinions and views of relevant government, academic and private sector agencies and organizations. A listing of those contacted, excluding the Department of Energy, is provided. In addition to interviews, an extensive range of literature was drawn upon including memoranda, brochures, program statements, school-enrollment data, speeches and the like. It was determined during this study that a wide range of public and private institutions are actively involved in the energy-education field. Oil companies, utilities, public interest groups, schools, agencies at every level of government, and others are formulating and delivering education which is enormously varied. It was concluded, however, that the public is not being reached, partially because current efforts are unfocused and partially because the public has become inured to problems and resistant to many of the traditional means of education. The study found that within this crowded and varied energy education field the Department of Energy is well placed to begin to provide direction and focus to the widespread activity now occurring.

  3. Therapeutic Options in High-risk Non-muscle-invasive Bladder Cancer During the Current Worldwide Shortage of Bacille Calmette-Guerin

    NARCIS (Netherlands)

    Mostafid, A.H.; Redorta, J. Palou; Sylvester, R.; Witjes, J.A.

    2015-01-01

    Optimal management of high-risk non-muscle-invasive bladder cancer during the current bacillus Calmette-Guerin (BCG) shortage is challenging. Although no evidence-based guidelines exist for this specific situation, current management options can be adapted for when BCG supplies are limited or when

  4. How do international trade obligations affect policy options for obesity prevention? Lessons from recent developments in trade and tobacco control.

    Science.gov (United States)

    von Tigerstrom, Barbara

    2013-06-01

    Regulatory measures, including taxes and subsidies on food and beverage products, food labelling requirements, regulation of food content and regulation of food marketing, have been proposed to encourage healthier eating and prevent obesity. The objective of this article is to explore the extent to which international trade agreements affect governments' choices to use such regulatory measures. It reviews key provisions of relevant World Trade Organization (WTO) agreements and their implications. Some insights can be gained by examining 2 recent developments in the WTO regarding tobacco control: a current dispute involving Australia's plain packaging law and its effect on trademarks, and a recent decision involving the United States law banning flavoured cigarettes. This decision said that the ban did not restrict trade more than necessary to fulfil its legitimate health objective, but it was discriminatory because it banned imported products (clove cigarettes) while exempting domestic products (menthol cigarettes) with similar characteristics. The conclusion we can draw from this decision is that WTO member states probably enjoy a significant degree of latitude in developing food regulations as part of an obesity prevention strategy, so long as those do not disproportionately affect imported products and therefore raise questions of discrimination. The approach taken in this case encourages the adoption of public health policies that are consistent with strong scientific evidence, but may restrict governments' ability to make political compromises, which could frustrate some proposals. The ongoing development of WTO law will continue to affect policy choices in public health. Copyright © 2013 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.

  5. Governance and the Gulf of Mexico Coast: How Are Current Policies Contributing to Sustainability?

    Directory of Open Access Journals (Sweden)

    Stephen Jordan

    2013-11-01

    Full Text Available The quality of life and economies of coastal communities depend, to a great degree, on the ecological integrity of coastal ecosystems. Paradoxically, as more people are drawn to the coasts, these ecosystems and the services they provide are increasingly stressed by development and human use. Employing the coastal Gulf of Mexico as an example, we explore through three case studies how government policies contribute to preventing, mitigating, or exacerbating the degradation of coastal ecosystems. We consider the effectiveness of the current systems, what alternate or additional policy solutions might be needed to ensure the sustainability of the region and its quality of life, and what this example can tell us about the sustainability of coastal systems globally. In our examples, among other aspects, policies that are proactive and networked governance structures are observed to favor sustainable outcomes, in contrast to reactive policies and hierarchical models of governance.

  6. Combined Heat and Power (CHP) as a Compliance Option under the Clean Power Plan: A Template and Policy Options for State Regulators

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-07-30

    Combined Heat and Power (CHP) is an important option for states to consider in developing strategies to meet their emission targets under the US Environmental Protection Agency's Clean Power Plan. This Template is designed to highlight key issues that states should consider when evaluating whether CHP could be a meaningful component of their compliance plans. It demonstrates that CHP can be a valuable approach for reducing emissions and helping states achieve their targets. While the report does not endorse any particular approach for any state, and actual plans will vary dependent upon state-specific factors and determinations, it provides tools and resources that states can use to begin the process, and underscores the opportunity CHP represents for many states. . By producing both heat and electricity from a single fuel source, CHP offers significant energy savings and carbon emissions benefits over the separate generation of heat and power, with a typical unit producing electricity with half the emissions of conventional generation. These efficiency gains translate to economic savings and enhanced competitiveness for CHP hosts, and emissions reductions for the state, along with helping to lower electric bills; and creating jobs in the design, construction, installation and maintenance of equipment. In 2015, CHP represents 8 percent of electric capacity in the United States and provides 12 percent of total power generation. Projects already exist in all 50 states, but significant technical and economic potential remains. CHP offers a tested way for states to achieve their emission limits while advancing a host of ancillary benefits.

  7. Instruments and options for environmental policy during the accession process of EU associated countries in the area of environment and energy. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cames, M.; Matthes, F.C.; Baer, S.; Oberthuer, S.; Krug, M.; Mez, L.; Tempel, S.

    2001-07-01

    With regard to the leading role of the EU in climate protection policies, it is important to consider the impact of the accession process on EU climate policy. This study includes the analysis of the most important issues related to environment and energy within the accession process, namely: 1) status quo and development of the energy sector and structural CO{sub 2} mitigation options; 2) legal gap assessment and analysis of performance in the accession process; 3) identification of implementation patterns through detailed policy analysis; 4) evaluation of co-operation projects in the field of environment and energy in order to develop new projects that promote the accession process. This volume includes comparative analysis of the five Accession Countries. The detailed analysis of each country is documented in five country reports, each in a separate volume available only on the attached CD. (orig.)

  8. Short-run analysis of fiscal policy and the current account in a finite horizon model

    OpenAIRE

    Heng-fu Zou

    1995-01-01

    This paper utilizes a technique developed by Judd to quantify the short-run effects of fiscal policies and income shocks on the current account in a small open economy. It is found that: (1) a future increase in government spending improves the short-run current account; (2) a future tax increase worsens the short-run current account; (3) a present increase in the government spending worsens the short-run current account dollar by dollar, while a present increase in the income improves the cu...

  9. Soft regulations in pharmaceutical policy making : an overview of current approaches and their consequences

    NARCIS (Netherlands)

    Wettermark, B.; Godman, B.; Jacobsson, B.; Haaijer-Ruskamp, F.M.

    2009-01-01

    It is a challenge to improve public health within limited resources. Pharmaceutical policy making is a greater challenge due to conflicting interests between key stakeholder groups. This paper reviews current and future strategies to help improve the quality and efficiency of care, with special emph

  10. Current Trends in Malaysian Higher Education and the Effect on Education Policy and Practice: An Overview

    Science.gov (United States)

    Grapragasem, Selvaraj; Krishnan, Anbalagan; Mansor, Azlin Norhaini

    2014-01-01

    Malaysia has evolved from a production-based to knowledge-based economy in order to stay relevant and compete in the global marketplace. Thus, the purpose of this article is to discuss current trends in Malaysian higher education and how these affect education policies and practices. Four main trends are discussed in this study: Globalization,…

  11. Place of Diversity in the Current Ethiopian Education and Training Policy: Analysis of Cardinal Dimensions

    Science.gov (United States)

    Sime, Tariku; Latchanna, Gara

    2016-01-01

    The purpose of this paper was to investigate to what extent the diversity dimensions are addressed in the current Education and Training Policy. To that end, document analysis was employed. The major diversity dimensions were analyzed based on their cardinal features. The study demonstrated that there is an ambitious need to address issues of…

  12. Bioenergy market competition for biomass: A system dynamics review of current policies

    Energy Technology Data Exchange (ETDEWEB)

    Jacob J. Jacobson; Robert Jeffers

    2013-07-01

    There is growing interest in the United States and abroad to increase the use of biomass as an energy source due to environmental and energy security benefits. In the United States, the biofuel and biopower industries are regulated by different policies and different agencies and have different drivers, which impact the maximum price the industries are willing to pay for biomass. This article describes a dynamic computer simulation model that analyzes future behavior of bioenergy feedstock markets based on varying policy and technical options. The model simulates the long-term dynamics of these markets by treating advanced biomass feedstocks as a commodity and projecting the total demand of each industry, as well as the market price over time. The model is used for an analysis of the United States bioenergy feedstock market that projects supply, demand, and market price given three independent buyers: domestic biopower, domestic biofuels, and foreign exports. With base-case assumptions, the biofuels industry is able to dominate the market and meet the federal Renewable Fuel Standard (RFS) targets for advanced biofuels. Further analyses suggest that United States bioenergy studies should include estimates of export demand for biomass in their projections, and that GHG-limiting policy would partially shield both industries from export dominance.

  13. Can all cause readmission policy improve quality or lower expenditures? A historical perspective on current initiatives.

    Science.gov (United States)

    Burgess, James F; Hockenberry, Jason M

    2014-04-01

    All-cause readmission to inpatient care is of wide policy interest in the United States and a number of other countries (Centers for Medicare and Medicaid Services, in the United Kingdom by the National Centre for Health Outcomes Development, and in Australia by the Australian Institute of Health and Welfare). Contemporary policy efforts, including high powered incentives embedded in the current US Hospital Readmission Reduction Program, and the organizationally complex interventions derived in anticipation of this policy, have been touted based on potential cost savings. Strong incentives and resulting interventions may not enjoy the support of a strong theoretical model or the empirical research base that are typical of strong incentive schemes. We examine the historical broad literature on the issue, lay out a 'full' conceptual organizational model of patient transitions as they relate to the hospital, and discuss the strengths and weaknesses of previous and proposed policies. We use this to set out a research and policy agenda on this critical issue rather than attempt to conduct a comprehensive structured literature review. We assert that researchers and policy makers should consider more fundamental societal issues related to health, social support and health literacy if progress is going to be made in reducing readmissions.

  14. Current status of alcohol marketing policy--an urgent challenge for global governance.

    Science.gov (United States)

    Casswell, Sally

    2012-03-01

    To review research literature and available information on the extent and impacts of marketing, current policy response and the interests engaged in the policy debate in order to inform recommendations for policy change on alcohol marketing. Relevant literature, including systematic reviews and publicly available information (websites and participant observation) is reviewed and synthesized. Alcohol marketing has expanded markedly in the past 50 years and, while there remains uncertainty about the impact across the population, there is now clear evidence of its impact on the consumption of young people. Few countries have effective policy in place restricting alcohol marketing, and there is a lack of an international response to alcohol marketing which crosses national boundaries. The protection of alcohol marketing has been a major focus for vested interest groups and this has affected governmental response at national and international levels. There has been a lack of non-governmental organization engagement. The policy response to tobacco marketing provides a clear contrast to that of alcohol marketing policy and provides a model for alcohol marketing policy. The global exposure of young people to alcohol marketing requires an urgent policy response. The Framework Convention on Tobacco Control provides an appropriate model for global governance to control alcohol marketing. There are extant examples of national level legislation achieving comprehensive bans with France's Loi Evin providing a feasible model. Resources from philanthropic organizations to allow non-governmental organization engagement are urgently required, as is engagement by the governmental sector independent of commercial influence. © 2012 The Author, Addiction © 2012 Society for the Study of Addiction.

  15. Global forces and local currents in Argentina's science policy crossroads: restricted access or open knowledge

    Directory of Open Access Journals (Sweden)

    Horacio Javier Etchichury

    2014-11-01

    Full Text Available The article describes the tensions between two competing approaches to scientific policy in Argentina. The traditional vision favors autonomous research. The neoliberal conception fosters the link between science and markets. In the past few years, a neodevelopmentalist current also tries to stress relevance of scientific research. Finally, the article describes how the Open Access movement has entered the debate. The World Bank intervention and the human rights dimension of the question are discussed in depth. The article introduces the notion of open knowledge as a guiding criterion to design a human-rights based scientific policy.

  16. System-wide and Superemitter Policy Options for the Abatement of Methane Emissions from the U.S. Natural Gas System.

    Science.gov (United States)

    Mayfield, Erin N; Robinson, Allen L; Cohon, Jared L

    2017-05-02

    This work assesses trade-offs between system-wide and superemitter policy options for reducing methane emissions from compressor stations in the U.S. transmission and storage system. Leveraging recently collected national emissions and activity data sets, we developed a new process-based emissions model implemented in a Monte Carlo simulation framework to estimate emissions for each component and facility in the system. We find that approximately 83% of emissions, given the existing suite of technologies, have the potential to be abated, with only a few emission categories comprising a majority of emissions. We then formulate optimization models to determine optimal abatement strategies. Most emissions across the system (approximately 80%) are efficient to abate, resulting in net benefits ranging from $160M to $1.2B annually across the system. The private cost burden is minimal under standard and tax instruments, and if firms market the abated natural gas, private net benefits may be generated. Superemitter policies, namely, those that target the highest emitting facilities, may reduce the private cost burden and achieve high emission reductions, especially if emissions across facilities are highly skewed. However, detection across all facilities is necessary regardless of the policy option and there are nontrivial net benefits resulting from abatement of relatively low-emitting sources.

  17. Ethical issues in the translation of social neuroscience: a policy analysis of current guidelines for public dialogue in human research.

    Science.gov (United States)

    Zimmerman, Emma; Racine, Eric

    2012-01-01

    Social neuroscience and its potential implications create an interesting case study for examining human research ethics policies on the topic of public communication of research. We reviewed mainstream national and international human research ethics guidelines and policies on issues of public communication of research. Our analysis relied on five thematic nets to capture the interactions between research and the public: public understanding, knowledge translation, public participation, social outcomes, and dual use. Coverage of these topics is sparse and inconsistent in mainstream policies and guidelines. We identify three options to address these gaps and analyze their strengths and weaknesses.

  18. Inclusive pedagogy in Australian universities: A review of current policies and professional development activities

    Directory of Open Access Journals (Sweden)

    Danielle Hitch

    2015-03-01

    Full Text Available This article reports on activities undertaken by Australian universities to support academic staff to provide inclusive teaching. The findings of two lines of inquiry are reported - a desktop audit of the presence of inclusive teaching or universal design for learning (UDL in publically available policies and procedures documents, and a survey of the methods adopted to build staff capacity to provide inclusive teaching and learning. Just over a third (34.21% of Australian universities referred to inclusive teaching or UDL in their policies and procedures. A wide range of current practices in professional development for inclusive teaching was reported, with the most frequent being one-off workshops focussing on accommodating specific groups of students. Improved institutional support through policies, procedures and professional development would enable Australian higher education teachers to provide quality inclusive teaching to all students.

  19. [Afatinib in patients with squamous cell carcinoma of the lung: current context and the option of oral treatment].

    Science.gov (United States)

    Cobo, Manuel; Gutiérrez, Vanesa; Rodelo, Luis; López, Omar; Ruiz, María; Godoy, Ana

    2016-04-01

    Squamous cell carcinoma (SCC) of the lung represents 30% of non-small cell lung cancers (NSCLC). Docetaxel and the EGFR tyrosine kinase inhibitor (TKI), erlotinib, are the only two drugs approved for second-line treatment of advanced SCC. The sensitivity of SCC to TKIs can be explained by EGFR overexpression. Erlotinib demonstrated a significant benefit in terms of overall survival (OS) in successive lines in NSCLC, including squamous histology. The magnitude of this benefit is similar to that of chemotherapy. Afatinib is an irreversible inhibitor of the entire ErbB family (EGFR, HER2-4) that has recently been approved for its current indication, advanced EGFR mutation-positive NSCLC and has well-defined and manageable toxicity, mainly gastrointestinal and cutaneous. The LUX-Lung 8 study was a phase III randomized trial in patients with NSCLC with squamous histology that compared erlotinib versus afatinib as second-line treatment. A total of 795 patients were included and a significant benefit was observed for afatinib in progression-free survival (2.7 vs 1.9 months (HR 0.79 [95%CI 0.68-0.91]; p=0.0012) and in OS (7.9 vs 6.8 months (HR 0.81 [95%CI 0.69-0.95]; p=0.0077), as well as a significant improvement in OS at 12 and 18 months. More diarrhoea and stomatitis was observed with afatinib and more rash with erlotinib, but the overall proportion of toxicity was similar in each group. Afatinib offered better results in quality of life. In summary, afatinib is a second-line treatment option in squamous NSCLC based on its survival advantage over erlotinib.

  20. Iran`s petroleum policy: Current trends and the future outlook

    Energy Technology Data Exchange (ETDEWEB)

    Pezeshki, S.; Fesharaki, F.

    1994-12-01

    The Iranian economy and political situation have undergone radical changes since the 1979 Islamic revolution. The excesses of the early years of the revolution have gradually given way to moderation and a more pragmatic economic policy--based on the principles of the free market. The petroleum policy, as a subset of the economic policies, has been somewhat affected by the political and economic developments in Iran. The petroleum policy has changed from a position of no foreign participation to a position that includes a desire for foreign participation, the text of a model contract, and an attempt to introduce new technologies in the upstream sector. This report provides an overview of the key issues facing the Iranian oil industry and the economic context in which the oil industry is operating in Iran. It describes the evolution of policies meant to move the oil industry toward the free market; it discusses Iran`s oil trading partners, the outlook for refining and project investments, and current and likely future developments in the natural gas and petrochemical sectors. In short, the report provides an up-to-date assessment of the Iranian petroleum sector and its likely evolution in the future.

  1. Impact of current policies on future air quality and health outcomes in Delhi, India

    Science.gov (United States)

    Dholakia, Hem H.; Purohit, Pallav; Rao, Shilpa; Garg, Amit

    2013-08-01

    A key policy challenge in Indian megacities is to curb high concentrations of PM2.5 and mitigate associated adverse health impacts. Using the Greenhouse Gases and Air Pollution Interactions and Synergies (GAINS) model we carry out an integrated analysis of the air quality regulations across different sectors for the city of Delhi. Our findings show that PM2.5 concentrations for Delhi will not reach the recommended national ambient air quality standards (NAAQS) even by 2030 under the current policies scenario. Adopting advanced control technologies reduces PM2.5 concentrations by about 60% and all-cause mortality by half in 2030. Climate change mitigation policies significantly reduce greenhouse gases, but have a modest impact on reducing PM2.5 concentrations. Stringent policies to control the net flow of air pollution from trans-boundary sources will play a crucial role in reducing pollution levels in Delhi city. Achieving NAAQS requires a stringent policy portfolio that combines advanced control technologies with a switch to cleaner fuels and the control of trans-boundary pollution.

  2. Transboundary Movements of Hazardous Wastes. A Comparative Analysis of Policy Options to Control the International Waste Trade.

    Science.gov (United States)

    Hilz, Christoph; Ehrenfeld, John R.

    1991-01-01

    Several policy frameworks for managing hazardous waste import/export are examined with respect to economic issues, environmental sustainability, and administrative feasibility and effectiveness. Several recommendations for improving the present instrument and implementing process are offered. (Author/CW)

  3. RUSSIAN GOVERNMENTAL INDUSTRIAL POLICY IMPLEMENTATION OPTIONS: SEARCHING FOR THE WAY OF RECOVERY FROM “DUTCH DISEASE”

    Directory of Open Access Journals (Sweden)

    Sergey Kapkanshchikov

    2012-01-01

    Full Text Available Based on the market failure theory the author argues that market mechanism is unable to undertake solid structural change in the national economics concluding that establishment of the governmental industrial policy is necessary. Mechanism of the “Dutch disease” with its local implications is disclosed. On the basis of comparison of various industrial policy scenarios appropriate for the Russian economics the author defines the most suitable one.

  4. Option pricing and foreign investment under political risk

    NARCIS (Netherlands)

    Cherian, J. A.; Perotti, E.C.

    2001-01-01

    The paper analyses asset prices in a context of uncertainty over future government policy. As current policy is maintained, perceived risk abates thus leading to a gradual appreciation of asset prices and a gradual decrease in their conditional variance. Option values computed under this process hav

  5. Policy change to create supportive environments for physical activity and healthy eating: which options are the most realistic for local government?

    Science.gov (United States)

    Allender, Steven; Gleeson, Erin; Crammond, Brad; Sacks, Gary; Lawrence, Mark; Peeters, Anna; Loff, Bebe; Swinburn, Boyd

    2012-06-01

    The objective is to identify and test regulatory options for creating supportive environments for physical activity and healthy eating among local governments in Victoria, Australia. A literature review identified nine potential areas for policy intervention at local government level, including the walking environment and food policy. Discussion documents were drafted which summarized the public health evidence and legal framework for change in each area. Levels of support for particular interventions were identified through semi-structured interviews conducted with key informants from local government. We conducted 11 key informant interviews and found support for policy intervention to create environments supportive of physical activity but little support for policy changes to promote healthy eating. Participants reported lack of relevance and competing priorities as reasons for not supporting particular interventions. Promoting healthy eating environments was not considered a priority for local government above food safety. There is a real opportunity for action to prevent obesity at local government level (e.g. mandate the promotion of healthy eating environments). For local government to have a role in the promotion of healthy food environments, regulatory change and suitable funding are required.

  6. Developing Public Policy Options for Access to Drinking Water in Peripheral, Disaster and Polluted Rural Areas: A Case Study on Environment-Friendly and Conventional Technologies

    Directory of Open Access Journals (Sweden)

    Ruxandra Mălina Petrescu-Mag

    2016-03-01

    Full Text Available Peripheral, disaster and polluted rural areas (PDP rural areas are generally perceived as a “Cinderella” of water public policy measures, deepening the rural-urban cleavage in terms of opportunities for a decent life. The main goal of the study is to develop public policy options regarding the supply of safe drinking water in Romanian PDP rural areas. The main instrument to achieve it is an ex-ante policy analysis of three solutions: a conventional technology, based on chlorine, a green technology using an advanced oxidation process with bio-filter (O3BioFilter, and “do nothing”. Environment protection, social equity, technical performance, economic efficiency and political feasibility were the criteria selected for analysis, within a focus-group. Several qualitative and quantitative methods were used: evaluation matrix, weighted cost-effectiveness and break-even point. The results of the first two indicate that the O3BioFilter has the best score, but not much higher than the conventional alternative (10% higher, revealing a possible path-dependency to familiar technologies. This analysis is not a ready-made solution valid in any case, nor a direct indication of “the best choice”, but a decision tool in the adoption and implementation of sustainable water public policies.

  7. Pan-European backcasting exercise, enriched with regional perspective, and including a list of short-term policy options

    OpenAIRE

    KOK, K.; Vliet, Van; Bärlund, I.; Sendzimir, J.; Dubel, A.

    2011-01-01

    This deliverable reports on the results of the third and final pan-European stakeholder meeting and secondly, on the enrichment with a Pilot Area and regional perspective. The main emphasis is on backcasting as a means to arrive at long-term strategies and short-term (policy) actions.

  8. Policy options to reduce consumer waste to zero: comparing product stewardship and extended producer responsibility for refrigerator waste.

    Science.gov (United States)

    Nicol, Scott; Thompson, Shirley

    2007-06-01

    Today, over-consumption, pollution and resource depletion threaten sustainability. Waste management policies frequently fail to reduce consumption, prevent pollution, conserve resources and foster sustainable products. However, waste policies are changing to focus on lifecycle impacts of products from the cradle to the grave by extending the responsibilities of stakeholders to post-consumer management. Product stewardship and extended producer responsibility are two policies in use, with radically different results when compared for one consumer product, refrigerators. North America has enacted product stewardship policies that fail to require producers to take physical or financial responsibility for recycling or for environmentally sound disposal, so that releases of ozone depleting substances routinely occur, which contribute to the expanding the ozone hole. Conversely, Europe's Waste Electrical and Electronic Equipment (WEEE) Directive requires extended producer responsibility, whereby producers collect and manage their own post-consumer waste products. WEEE has resulted in high recycling rates of greater than 85%, reduced emissions of ozone-depleting substances and other toxins, greener production methods, such as replacing greenhouse gas refrigerants with environmentally friendly hydrocarbons and more reuse of refrigerators in the EU in comparison with North America.

  9. How to Expand and Improve Preschool in California: Ideals, Evidence, and Policy Options. Working Paper 05-1

    Science.gov (United States)

    Fuller, Bruce; Livas, Alejandra; Bridges, Margaret

    2006-01-01

    The new call for a universal preschool system is prompting an important policy debate across California. How preschooling is expanded and improved with limited public resources depends on several key issues. The hopeful ideals of "preschool for all"--with children beginning school ready to learn--spark enthusiasm and broaden public will.…

  10. RUSSIAN POLICY IN POST-SOVIET SPACE: MILESTONES AND CURRENT STATUS

    Directory of Open Access Journals (Sweden)

    Sergey Valerievich Bespalov

    2014-08-01

    Full Text Available The paper examines the main trends in the development of bilateral relations in the post-Soviet Eurasia and is characterized the evolution of Russian foreign policy in the post-Soviet space using historiosophical and comparative research methods. Formulated periodization of Russian policy toward the region , taking into account the geopolitical , foreign , domestic economic and domestic factors. Current state of Russian policy towards neighboring countries and the prospects for improving its performance are analyzed in the article. The author identifies the main problem areas of the current state of international relations in the region and identifies opportunities available to Russia to strengthen the integration processes. Concludes that , without abandoning the appeal in a number of cases to the general traditions common historical experience accumulated over decades or even centuries of living together within a single state and remains an important resource in Russian politics , Russia needs to position itself as a state, able to provide its partners those preferences and assistance ( financial, informational , educational services , etc. , which they need , and who expect to get - usually without good reason - other centers of world politics . Offers practical guidance for experts, politicians , managers and representatives of public organizations.

  11. The Policy of Choice: Expanding Student Options in Higher Education. The New Millennium Project on Higher Education Costs, Pricing, and Productivity.

    Science.gov (United States)

    Cunningham, Alisa Federico

    This report discusses what college choice means and how it works. Exploring in some detail the various definitions of choice, the report reveals what is known about the factors that influence students decisions, and the current status of choice. The analysis focuses on choice in relation to federal need-based financial aid policy. Higher education…

  12. Virtuous and Vicious Circles: Lessons for Current European Policies from Italian Post-War Development

    Directory of Open Access Journals (Sweden)

    Gioacchino Garofoli

    2017-06-01

    Full Text Available The paper deals with the Italian economic development, explaining the main features and the crucial variables in the long-term transformation process. The Italian economy has been analysed taking into account the different and changing international rules in medium and long-term to understand their role on the development strategies and on the changing competitive position of the country. The comparative international analysis on selected crucial variables shows some contradictions between expectations and effective outcomes of changing institutional rules and introduced economic policies. This underlines both the emergence of unexpected trajectories and economic performances and the lasting of structural differences among European countries. The selection of consistent economic policies in Europe, then, should take into account these phenomena. The paper underlines the crucial role of long-term economic analysis to fully understand not only the crucial structural variables but even opportunities and challenges for strategic decisions in the current economic crisis.

  13. The Social Lives of Global Policies against Malaria: Conceptual Considerations, Past Experiences, and Current Issues.

    Science.gov (United States)

    Eckl, Julian

    2017-07-01

    While a casual observer might easily get the impression that global policies against malaria have unanimous support, there are strongly divergent perspectives on malaria control. Analyzing ethnographic and historical material through a political science lens, I foreground the social negotiation of malaria both as an illness experience of affected populations and as a disease problem defined by experts. Taking the interrelationship between problems, solutions, and solution providers as a point of departure, I reconstruct recurrent tensions and social mechanisms that can account for the tendency to downplay conflicts and to produce technical-biomedical solutions that seem to be irresistible. This helps to overcome the perception that current policies have no alternatives and that aiming directly for malaria eradication is the only form of sustainability in times of resistances when "saving the established technical-biomedical solutions" has become a key concern.

  14. Policy and Practice Options for Equitable Access to Primary Healthcare for Indigenous Peoples in British Columbia and Norway

    Directory of Open Access Journals (Sweden)

    Josée G. Lavoie

    2014-04-01

    Full Text Available Over the past three decades, policy reforms have been geared towards improving quality of care, responsiveness, and equitable access to healthcare services for all social groups in general, and individuals living in marginalizing circumstances in particular. The purpose of this study was to document how primary healthcare services (PHC services are provided in Norway and British Columbia to meet the needs of Indigenous peoples and use this knowledge to critically explore policy alternatives that inform the delivery of PHC for vulnerable populations. Findings show that in British Columbia, Indigenous-specific PHC services have been the preferred mechanism to ensure better care. This is not the case in Norway, where Sámi-centric services exist only in mental health and only in Finnmark.

  15. Current systematic carbon cycle observations and needs for implementing a policy-relevant carbon observing system

    Directory of Open Access Journals (Sweden)

    P. Ciais

    2013-07-01

    Full Text Available A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify the effectiveness of policies aiming to reduce greenhouse gas emissions and increase carbon sequestration. Building an integrated carbon observation system requires transformational advances from the existing sparse, exploratory framework towards a dense, robust, and sustained system in all components: anthropogenic emissions, the atmosphere, the ocean, and the terrestrial biosphere. The goal of this study is to identify the current state of carbon observations and needs for a global integrated carbon observation system that can be built in the next decade. A key conclusion is the substantial expansion (by several orders of magnitude of the ground-based observation networks required to reach the high spatial resolution for CO2 and CH4 fluxes, and for carbon stocks for addressing policy relevant objectives, and attributing flux changes to underlying processes in each region. In order to establish flux and stock diagnostics over remote areas such as the southern oceans, tropical forests and the Arctic, in situ observations will have to be complemented with remote-sensing measurements. Remote sensing offers the advantage of dense spatial coverage and frequent revisit. A key challenge is to bring remote sensing measurements to a level of long-term consistency and accuracy so that they can be efficiently combined in models to reduce uncertainties, in synergy with ground-based data. Bringing tight observational constraints on fossil fuel and land use change emissions will be the biggest challenge for deployment of a policy-relevant integrated carbon observation system. This will require in-situ and remotely sensed data at much higher resolution and density than currently achieved for natural fluxes, although over a small land area (cities, industrial

  16. Current Policies and New Directions for Speech-Language Pathology Assistants.

    Science.gov (United States)

    Paul-Brown, Diane; Goldberg, Lynette R

    2001-01-01

    This article provides an overview of current American Speech-Language-Hearing Association (ASHA) policies for the appropriate use and supervision of speech-language pathology assistants with an emphasis on the need to preserve the role of fully qualified speech-language pathologists in the service delivery system. Seven challenging issues surrounding the appropriate use of speech-language pathology assistants are considered. These include registering assistants and approving training programs; membership in ASHA; discrepancies between state requirements and ASHA policies; preparation for serving diverse multicultural, bilingual, and international populations; supervision considerations; funding and reimbursement for assistants; and perspectives on career-ladder/bachelor-level personnel. The formation of a National Leadership Council is proposed to develop a coordinated strategic plan for addressing these controversial and potentially divisive issues related to speech-language pathology assistants. This council would implement strategies for future development in the areas of professional education pertaining to assistant-level supervision, instruction of assistants, communication networks, policy development, research, and the dissemination/promotion of information regarding assistants.

  17. Balancing Fiscal, Energy, and Environmental Concerns: Analyzing the Policy Options for California’s Energy and Economic Future

    Directory of Open Access Journals (Sweden)

    Edward Manderson

    2013-03-01

    Full Text Available This study estimates the fiscal, energy, and environmental tradeoffs involved in supplying California’s future energy needs. An integrated framework is developed whereby an econometric forecasting system of California energy demand is coupled with engineering-economic models of energy supply, and economic impacts are estimated using input-output models of the California economy. A baseline scenario in which California relies on imported electricity to meet future demand is then compared against various energy supply development scenarios over the forecast horizon (2012–2035. The results indicate that if California implements its renewable portfolio standard (RPS, there will be a substantial net cost in terms of value added, employment, and state tax revenues because the economic benefits of building capacity are outweighed by higher energy prices. Although carbon emissions fall, the cost per ton of avoided emissions is well above market prices. Building out natural gas fired generation capacity also leads to losses compared to the baseline, although the impacts are relatively minor. Meanwhile, a strategy of replacing imported crude oil and natural gas with domestic production using indigenous resources increases gross state product, employment, and tax revenues, with minimal impact on carbon emissions. This option could, therefore, help mitigate the costs of California meeting its RPS commitment.

  18. Sustainable alternatives for land-based biofuels in the European Union. Assessment of options and development of a policy strategy

    Energy Technology Data Exchange (ETDEWEB)

    Kampman, B.; Van Grinsven, A.; Croezen, H.

    2012-12-15

    It is feasible for EU member states to meet their commitments regarding transport fuels under the Renewable Energy Directive (RED) and the Fuel Quality Directive (FQD) without resorting to biofuels from food crops. The RED target (10% renewable transport energy in 2020) can be met by a mix of measures aimed at improving energy efficiency, combined with a strong focus on growth of renewable electricity use and biofuels and biomethane from waste and residues. These measures also contribute to the FQD target (6% reduction in carbon intensity of fuels by 2020), but will need to be complemented by other measures such as reduced flaring and venting during oil production. The report shows how EU transport energy policy could reduce its reliance on biofuels from food crops that are likely to cause land use change. This alternative vision for the transport sector in 2020 would cut CO2 emissions by 205 million tonnes.

  19. Online media coverage of air pollution risks and current policies in India: A content analysis.

    Science.gov (United States)

    Murukutla, Nandita; Negi, Nalin S; Puri, Pallavi; Mullin, Sandra; Onyon, Lesley

    2017-09-01

    institution or organization - such as the government or industry groups - as the primary responsible stakeholder, thus leaving ambiguous the organizations whose leadership was necessary to mitigate air pollution. Conclusion Gaps exist in the current media discourse on air pollution, suggesting the need for strengthening engagement with the media as a means of creating citizen engagement and enabling policy action. Through greater elaboration of the health burdens and evidence-based policy actions, the media can play a critical role in galvanizing India's action on air quality. These data may suggest opportunities for media advocacy and greater public and policy engagement to address issues around air quality in India.

  20. Wind Power Policy Evaluation in China Using Real Option Model%基于实物期权的中国风电发展政策评估

    Institute of Scientific and Technical Information of China (English)

    田立新; 许培琳; 傅敏

    2013-01-01

    Based on the theory of real options, this paper establishes a policy benefit model that can be used to evaluate the development of wind power considering four uncertain factors: thermal power generating cost, wind power generating cost, carbon price, incentives and subsidies from the government. By setting different coefficients of subsidy, the paper analyzes its effects on the total de-cisional value and achieves the optimal investment timing under various situations. The research helps the government assess the projects of renewable resources, which may contain some uncertainties and make relevant policies.%考虑火电发电成本、风电发电成本、碳排放权价格及政府的鼓励与补贴4种不确定因素,基于实物期权理论从政府的视角,建立评估风电发展的决策价值模型.通过设定不同的政策补贴系数,分析政策补贴对总决策价值的影响,并给出各种情境下的最佳投资时机.

  1. US Interagency Regional Foreign Policy Implementation: A Survey of Current Practice and an Analysis of Options for Improvement

    Science.gov (United States)

    2014-06-01

    more similar than, say, a military officer and Foreign Service officer, it’s hard to dismiss the shock that the sud - den “jointness” brought to the...Coordinating draft. Laurel, MD: Johns Hopkins University Applied Physics Laboratory , 19 October 2009. McGeary, Johanna. “Looking beyond Saddam.” Time 161, no

  2. Energy Drink Consumption in Europe: A Review of the Risks, Adverse Health Effects, and Policy Options to Respond

    Science.gov (United States)

    Breda, João Joaquim; Whiting, Stephen Hugh; Encarnação, Ricardo; Norberg, Stina; Jones, Rebecca; Reinap, Marge; Jewell, Jo

    2014-01-01

    With the worldwide consumption of energy drinks increasing in recent years, concerns have been raised both in the scientific community and among the general public about the health effects of these products. Recent studies provide data on consumption patterns in Europe; however, more research is needed to determine the potential for adverse health effects related to the increasing consumption of energy drinks, particularly among young people. A review of the literature was conducted to identify published articles that examined the health risks, consequences, and policies related to energy drink consumption. The health risks associated with energy drink consumption are primarily related to their caffeine content, but more research is needed that evaluates the long-term effects of consuming common energy drink ingredients. The evidence indicating adverse health effects due to the consumption of energy drinks with alcohol is growing. The risks of heavy consumption of energy drinks among young people have largely gone unaddressed and are poised to become a significant public health problem in the future. PMID:25360435

  3. Energy drink consumption in Europe: A review of the risks, adverse health effects and policy options to respond

    Directory of Open Access Journals (Sweden)

    João Joaquim Breda

    2014-10-01

    Full Text Available With the worldwide consumption of energy drinks increasing in recent years, concerns have been raised both in the scientific community and among the general public about the health effects of these products. Recent studies provide data on consumption patterns in Europe however more research is needed to determine the potential for adverse health effects related to the increasing consumption of energy drinks, particularly among young people. A review of the literature was conducted to identify published articles that examined the health risks, consequences and policies related to energy drink consumption. The health risks associated with energy drink consumption are primarily related to their caffeine content, but more research is needed that evaluates the long term effects of consuming common energy drink ingredients. The evidence indicating adverse health effects due to the consumption of energy drinks with alcohol is growing. The risks of heavy consumption of energy drinks among young people have largely gone unaddressed and are poised to become a significant public health problem in the future.

  4. Energy drink consumption in europe: a review of the risks, adverse health effects, and policy options to respond.

    Science.gov (United States)

    Breda, João Joaquim; Whiting, Stephen Hugh; Encarnação, Ricardo; Norberg, Stina; Jones, Rebecca; Reinap, Marge; Jewell, Jo

    2014-01-01

    With the worldwide consumption of energy drinks increasing in recent years, concerns have been raised both in the scientific community and among the general public about the health effects of these products. Recent studies provide data on consumption patterns in Europe; however, more research is needed to determine the potential for adverse health effects related to the increasing consumption of energy drinks, particularly among young people. A review of the literature was conducted to identify published articles that examined the health risks, consequences, and policies related to energy drink consumption. The health risks associated with energy drink consumption are primarily related to their caffeine content, but more research is needed that evaluates the long-term effects of consuming common energy drink ingredients. The evidence indicating adverse health effects due to the consumption of energy drinks with alcohol is growing. The risks of heavy consumption of energy drinks among young people have largely gone unaddressed and are poised to become a significant public health problem in the future.

  5. The impact of current visa regime policy on tourism recovery and development in Zimbabwe

    Directory of Open Access Journals (Sweden)

    Nelson Zengeni

    2012-12-01

    Full Text Available This paper reports the results on the impact of the current visa regime policy on tourism recovery and development in Zimbabwe. The focus was on finding out how the visa regime could impact on efforts to bring into the country more visitors following the decline in visitor inflows from 2000 to 2008. Data was collected from selected visitors from different member states which require visas to enter into the county in the period between January 2010 and July 2010.The findings shows that visa restrictions play a small part in discouraging visitors to visit Zimbabwe. The visa regime policy was designed in such a way that it was easy for passport holders from traditional markets to have relatively easy passage into Zimbabwe. It was also discovered that visa restrictions were part of international travel conditions but how to get the visa became the competitive advantage or disadvantage a destination can have compared with its competitors. Zimbabwe’s traditional markets believed that the visa was not difficult to get nor was it too expensive as to scare away visitors. However, the emerging markets such as China who are in Group C had problems getting the visa as they were required to apply for the visa before traveling to Zimbabwe.

  6. Haze, public health and mitigation measures in China: A review of the current evidence for further policy response.

    Science.gov (United States)

    Gao, Jinghong; Woodward, Alistair; Vardoulakis, Sotiris; Kovats, Sari; Wilkinson, Paul; Li, Liping; Xu, Lei; Li, Jing; Yang, Jun; Li, Jing; Cao, Lina; Liu, Xiaobo; Wu, Haixia; Liu, Qiyong

    2017-02-01

    With rapid economic development, China has been plagued by choking air pollution in recent years, and the frequent occurrence of haze episodes has caused widespread public concern. The purpose of this study is to describe the sources and formation of haze, summarize the mitigation measures in force, review the relationship between haze pollution and public health, and to discuss the challenges, potential research directions and policy options. Haze pollution has both natural and man-made causes, though it is anthropogenic sources that are the major contributors. Accumulation of air pollutants, secondary formation of aerosols, stagnant meteorological conditions, and trans-boundary transportation of pollutants are the principal causes driving the formation and evolution of haze. In China, haze includes gaseous pollutants and fine particles, of which PM2.5 is the dominant component. Short and long-term exposure to haze pollution are associated with a range of negative health outcomes, including respiratory diseases, cardiovascular and cerebrovascular diseases, mental health problems, lung cancer and premature death. China has paid increasing attention to the improvement of air quality, and has introduced action plans and policies to tackle pollution, but many interventions have only temporary effects. There may be fierce resistance from industry groups and some government agencies, and often it is challenging to enforce relevant control measures and laws. We discuss the potential policy options for prevention, the need for wider public dialogue and the implications for scientific research.

  7. Current Measures on Radioactive Contamination in Japan: A Policy Situation Analysis.

    Science.gov (United States)

    Gilmour, Stuart; Miyagawa, Shoji; Kasuga, Fumiko; Shibuya, Kenji

    2016-01-01

    radioactive contamination. Monitoring of radioactive materials in food products in the prefectures has been mainly conducted before shipment to restrict the distribution of radio-contaminated foods. Between March 2011 and March 2012, 133,832 tests of non-commercial and commercial products were conducted, and 1,204 tests (0.9%) were found to violate the provisional standards. Since April 2012, 278,275 tests were conducted, and 2,372 tests (0.9%) were found to violate the revised standards. MHLW assessment of representative market baskets of foodstuffs at 15 locations throughout Japan between February and March 2014 found very low estimated dietary intake of radioactive cesium (0.0007-0.019 mSv/year), as did assessments of the contents of an average day's food. Monitoring of fisheries products in coastal areas affected by the nuclear accident found very limited and declining radio-contamination of live fish outside of Fukushima prefecture. Fisheries monitoring is of limited geographical scope and covers only certain fishes. Area-specific bans on production and distribution have been effective in preventing radioactive contamination in the Japanese food market. Currently there is no major concern about radioactive cesium concentrations in retail foodstuffs in Japan, and very low levels of contamination at the production and wholesale stage. However, because the residue limits and food safety policies were revised on an ad hoc, emergency basis after the nuclear accident, the monitoring procedure needs to be reviewed based on objective and scientifically rational criteria. A transparent and objective scientific framework is needed for prioritizing foodstuffs for inspection and revising Prefecture-specific restrictions. Monitoring of fishes and other seafood products in the wild should be regularized and the information made more publicly accessible, and monitoring activities expanded to identify foodstuffs that are no longer a food safety risk. Consultation with producers and

  8. Policy options to improve leadership of middle managers in the Australian residential aged care setting: a narrative synthesis

    Science.gov (United States)

    2010-01-01

    Background The prevalence of both chronic diseases and multi-morbidity increases with longer life spans. As Australia's population ages, the aged care sector is under increasing pressure to ensure that quality aged care is available. Key to responding to this pressure is leadership and management capability within the aged care workforce. A systematic literature review was conducted to inform the policy development necessary for the enhancement of clinical and managerial leadership skills of middle managers within residential aged care. Methods Using scientific journal databases, hand searching of specialist journals, Google, snowballing and suggestions from experts, 4,484 papers were found. After a seven-tiered culling process, we conducted a detailed review (narrative synthesis) of 153 papers relevant to leadership and management development in aged care, incorporating expert and key stakeholder consultations. Results • Positive staff experiences of a manager's leadership are critical to ensure job satisfaction and workforce retention, the provision of quality care and the well-being of care recipients, and potentially a reduction of associated costs. • The essential attributes of good leadership for aged care middle management are a hands-on accessibility and professional expertise in nurturing respect, recognition and team building, along with effective communication and flexibility. However, successful leadership and management outcomes depend on coherent and good organisational leadership (structural and psychological empowerment). • There is inadequate preparation for middle management leadership roles in the aged care sector and a lack of clear guidelines and key performance indicators to assess leadership and management skills. • Theory development in aged care leadership and management research is limited. A few effective generic clinical leadership programs targeting both clinical and managerial leaders exist. However, little is known regarding

  9. Policy options to improve leadership of middle managers in the Australian residential aged care setting: a narrative synthesis

    Directory of Open Access Journals (Sweden)

    Merlyn Teri

    2010-07-01

    Full Text Available Abstract Background The prevalence of both chronic diseases and multi-morbidity increases with longer life spans. As Australia's population ages, the aged care sector is under increasing pressure to ensure that quality aged care is available. Key to responding to this pressure is leadership and management capability within the aged care workforce. A systematic literature review was conducted to inform the policy development necessary for the enhancement of clinical and managerial leadership skills of middle managers within residential aged care. Methods Using scientific journal databases, hand searching of specialist journals, Google, snowballing and suggestions from experts, 4,484 papers were found. After a seven-tiered culling process, we conducted a detailed review (narrative synthesis of 153 papers relevant to leadership and management development in aged care, incorporating expert and key stakeholder consultations. Results • Positive staff experiences of a manager's leadership are critical to ensure job satisfaction and workforce retention, the provision of quality care and the well-being of care recipients, and potentially a reduction of associated costs. • The essential attributes of good leadership for aged care middle management are a hands-on accessibility and professional expertise in nurturing respect, recognition and team building, along with effective communication and flexibility. However, successful leadership and management outcomes depend on coherent and good organisational leadership (structural and psychological empowerment. • There is inadequate preparation for middle management leadership roles in the aged care sector and a lack of clear guidelines and key performance indicators to assess leadership and management skills. • Theory development in aged care leadership and management research is limited. A few effective generic clinical leadership programs targeting both clinical and managerial leaders exist. However

  10. FAIR 1.0 (Framework to Assess International Regimes for differentiation of commitments): An interactive model to explore options for differentiation of future commitments in international climate policy making. User documentation

    NARCIS (Netherlands)

    Elzen MGJ den; Berk MM; Both S; Faber A; Oostenrijk R; CIM

    2001-01-01

    This report contains the model documentation and user instructions of the FAIR model (Framework to Assess International Regimes for differentiation of commitments). FAIR is an interactive - scanner-type - computer model to quantitatively explore a range of alternative climate policy options for inte

  11. FAIR 1.0 (Framework to Assess International Regimes for differentiation of commitments): An interactive model to explore options for differentiation of future commitments in international climate policy making. User documentation

    NARCIS (Netherlands)

    Elzen MGJ den; Berk MM; Both S; Faber A; Oostenrijk R; CIM

    2001-01-01

    This report contains the model documentation and user instructions of the FAIR model (Framework to Assess International Regimes for differentiation of commitments). FAIR is an interactive - scanner-type - computer model to quantitatively explore a range of alternative climate policy options for inte

  12. Current Measures on Radioactive Contamination in Japan: A Policy Situation Analysis.

    Directory of Open Access Journals (Sweden)

    Stuart Gilmour

    areas at risk of radioactive contamination. Monitoring of radioactive materials in food products in the prefectures has been mainly conducted before shipment to restrict the distribution of radio-contaminated foods. Between March 2011 and March 2012, 133,832 tests of non-commercial and commercial products were conducted, and 1,204 tests (0.9% were found to violate the provisional standards. Since April 2012, 278,275 tests were conducted, and 2,372 tests (0.9% were found to violate the revised standards. MHLW assessment of representative market baskets of foodstuffs at 15 locations throughout Japan between February and March 2014 found very low estimated dietary intake of radioactive cesium (0.0007-0.019 mSv/year, as did assessments of the contents of an average day's food. Monitoring of fisheries products in coastal areas affected by the nuclear accident found very limited and declining radio-contamination of live fish outside of Fukushima prefecture. Fisheries monitoring is of limited geographical scope and covers only certain fishes.Area-specific bans on production and distribution have been effective in preventing radioactive contamination in the Japanese food market. Currently there is no major concern about radioactive cesium concentrations in retail foodstuffs in Japan, and very low levels of contamination at the production and wholesale stage. However, because the residue limits and food safety policies were revised on an ad hoc, emergency basis after the nuclear accident, the monitoring procedure needs to be reviewed based on objective and scientifically rational criteria. A transparent and objective scientific framework is needed for prioritizing foodstuffs for inspection and revising Prefecture-specific restrictions. Monitoring of fishes and other seafood products in the wild should be regularized and the information made more publicly accessible, and monitoring activities expanded to identify foodstuffs that are no longer a food safety risk. Consultation with

  13. ANALYSIS OF THE CURRENT STATE ON LABOUR POLICIES IN THE ROMANIAN ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    BĂLĂNEASA MARIA-CRISTINA

    2013-02-01

    Full Text Available The policies on labour relations can be considered as the philosophy or values promoted by an organization and help ensure a unitary approach within it. The existence of such policies in each organization has the maximum utility because helps employees to understand the values promoted by them and the behaviour that must be adopted. The main areas that can be covered by policies concerning labour relations are human resources planning, the quality of the employees, hiring and promoting employees, work-life balance, non-discrimination, dismissal, work discipline, complains, substance abuse, smoking at work, employment and relations with employees infected with HIV and other fields mentioned in the paper. Throughout the study, the attention was given preponderantly on three categories of policies: discipline policy, equal opportunities policy and work-life balance policy, the last two also being promoted by European institutions. Therefore, these policies were analysed in practical terms within Romanian organizations. We found that discipline policies are widely used at work, while the other two types of policies exist at a lower percentage within the analysed establishments. Most units having such policies concerning non-discrimination and work-life balance are oversized. This situation requires action from the management of small and medium-sized units in order to draw up and respect the non-discrimination policy and the balance between work and family life.

  14. More than Kissing Babies? Current Child and Family Policy in the United States.

    Science.gov (United States)

    Jacobs, Francine H., Ed.; Davies, Margery W., Ed.

    Meant to orient a broad audience to basic issues of child and family policy in the United States today, this book includes an overview of the recent history of child and family policy in the United States, an exploration of several political economic conditions underlying changes in these policies, case studies of selected local, state and federal…

  15. PERFORMANCE MANAGEMENT – A VIABLE OPTION IN THE CURRENT CONTEXT OF POST-CRISIS ECONOMY IN ROMANIA

    OpenAIRE

    Vasile DEAC; Mihai VRÎNCUT; Paun, Oana

    2014-01-01

    The current crisis has revealed that in the “war” between suppliers and customers the power balance has finally swung towards the latter, and since companies act as both suppliers and customers to other entities apparently complicates their situation. A high performance implies minimizing the cost of “inputs” and maximizing revenues from “outputs”, which in turn requires an effective negotiation from the company both as client and supplier. While negotiation skills can give them a strategic a...

  16. Bad results obtained from the current public health policies and recommendations of hydration

    Directory of Open Access Journals (Sweden)

    Ismael San Mauro Martín

    Full Text Available Introduction: Achieving an adequate intake of water is crucial within a balanced diet. For that purpose, dietary guidelines for healthy eating and drinking are an important consideration and need to be updated and disseminated to the population. Aim: We aimed to evaluate the liquid intake habits of a Mediterranean and Latin American population (Spain-Portugal and Mexico-Uruguay and if they support the current recommendations of hydration by the EFSA. Methods: A record of fluid intake was obtained from 1,168 participants from 4 countries above; and then compared with current consensus about hydration 1,600 mL/day (female and 2,000 mL/day (male. Results: The average fluid intake slightly surpassed the recommended: mean of 2,049 mL/day (2,223 mL in males, 1,938 mL in females. Portugal stood out due to its lower intake (mean of 1,365 mL/day. Water contributed the largest part to total fluid intake (37% in all countries (mean of 1,365 mL/day. Hot beverages (18% and milk and derivates (17% follow water in highest consumption. The 20% of males and only 0.3% of females knew recommendations of hydration, while 63.3% of males and 62% of females followed them. Only 8.4% of people who follow the recommendations know them. Conclusion: The people studied surpassed the recommendation, although the majority did not realize. Future research should examine actual beverage consumption patterns and evaluate if the current consensuses are correctly adapted to the population needs. Hydration's policies should be transmitted to the population for their knowledge and adequate compliance.

  17. Is irrigation with partial desalinated seawater a policy option for saving freshwater in the Kingdom of Saudi Arabia

    Science.gov (United States)

    Multsch, Sebastian; Alquwaizany, Abdulaziz S.; Lehnert, Karl-H.; Frede, Hans-Georg; Breuer, Lutz

    2015-04-01

    The agriculture sector consumes with 88 % a majority of the almost fossil water resources in the Kingdom of Saudi Arabia (KSA). Irrigation with saline water has been highlighted to be a promising technique to reduce fresh water consumption. Current desalination techniques, further developments, salt tolerant crop types and improved irrigation systems can potentially redesign future perspectives for irrigation agriculture, in particular by considering the growing desalination capacity in KSA (5 million m3 day-1 in 2003). Hence, we have analyzed the potential of using desalinated and partial desalinated seawater for growing crops in KSA by considering scenarios of salinity levels and desalination costs. The desalination process has been modelled with the ROSA© software considering a reverse osmosis (RO) plant. The spatial decision support system SPARE:WATER has been applied to assess the water footprint of crops (WFcrop). In order to maintain high crop yields, salts need to be washed out from the rooting zone, which requires the application of additional salt-free water. Therefore, high crop yields come along with additional water requirements and increased desalination effort and increased costs for proving high quality water. As an example, growing wheat with partial desalinated seawater from the Arabian Gulf with a RO plant has been investigated. Desalination reduces the salinity level from 76 dS m-1 to 0.5 dS m-1 considering two RO cycles, with cost of desalinized water in the range of 0.5 to 1.2 m-3. We acknowledge that cost only refer to desalination without considering others such as transport, water pumping or crop fertilization. The study shows that Boron is the most problematic salt component, because it is difficult to remove by RO and toxic in high concentrations for crops (wheat threshold of 0.5 to 1.0 mg l-1). The nationwide average WFcrop of wheat under surface irrigation is 2,628 m3 t-1 considering high water quality of 1 dS m-1 and 3,801 m3 t-1 at

  18. Vasopressin Receptor Antagonists for the Correction of Hyponatremia in Chronic Heart Failure: An Underutilized Therapeutic Option in Current Clinical Practice?

    Directory of Open Access Journals (Sweden)

    Renato De Vecchis

    2016-10-01

    Full Text Available In the congestive heart failure (CHF setting, chronic hyponatremia is very common. The present review aims at addressing topics relevant to the pathophysiology of hyponatremia in the course of CHF as well as its optimal treatment, including the main advantages and the limitations resulting from the use of the available dietary and pharmacological measures approved for the treatment of this electrolytic trouble. A narrative review is carried out in order to represent the main modalities of therapy for chronic hyponatremia that frequently complicates CHF. The limits of usual therapies implemented for CHF-related chronic hyponatremia are outlined, while an original analysis of the main advancements achieved with the use of vasopressin receptor antagonists (VRAs is also executed. The European regulatory restrictions that currently limit the use of VRAs in the management of CHF are substantially caused by financial concerns, i.e., the high costs of VRA therapy. A thoughtful reworking of current restrictions would be warranted in order to enable VRAs to be usefully associated to loop diuretics for decongestive treatment of CHF patients with hyponatremia.

  19. Rehabilitation Options

    Science.gov (United States)

    ... Speech Pathology Occupational Therapy Art Therapy Recreational therapy Neuropsychology Home Care Options Advanced Care Planning Palliative Care ... Speech Pathology Occupational Therapy Art Therapy Recreational therapy Neuropsychology Home Care Options Advanced Care Planning Palliative Care ...

  20. Pricing Options.

    Science.gov (United States)

    Tenopir, Carol

    1998-01-01

    Presents results of a recent survey of over 100 public and academic libraries about pricing options from online companies. Most options fall into three categories: pay-as-you-go, fixed-rate, and user-based. Results are discussed separately for public and academic libraries and for consortial discounts. Trends in pricing options preferred by…

  1. A Study of Heavy Metal Pollution in China: Current Status, Pollution-Control Policies and Countermeasures

    Directory of Open Access Journals (Sweden)

    Hui Hu

    2014-09-01

    Full Text Available In the past 30 years, China’s economy has experienced rapid development, which led to a vast increase in energy consumption and serious environmental pollution. Among the different types of pollution, heavy metal pollution has become one of the major environmental issues in China. A number of studies show that high level of heavy metal exposure is a frequent cause of permanent intellectual and developmental disabilities. In recent years, some traditional pollutants, such as sulfur dioxide and carbon dioxide, have been put under control in China. However, heavy metal pollution, which poses even greater risks to public health and sustainable development, has yet to gain policymakers’ attention. The purpose of this paper is to explore effective countermeasures for heavy metal pollution in China. The present study reviews the current status of China’s heavy metal pollution and analyzes related public policies and countermeasures against that pollution. It also presents a few recommendations and measures for prevention of heavy metal pollution.

  2. NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy.

    Science.gov (United States)

    Pruitt, Kim D; Tatusova, Tatiana; Brown, Garth R; Maglott, Donna R

    2012-01-01

    The National Center for Biotechnology Information (NCBI) Reference Sequence (RefSeq) database is a collection of genomic, transcript and protein sequence records. These records are selected and curated from public sequence archives and represent a significant reduction in redundancy compared to the volume of data archived by the International Nucleotide Sequence Database Collaboration. The database includes over 16,00 organisms, 2.4 × 0(6) genomic records, 13 × 10(6) proteins and 2 × 10(6) RNA records spanning prokaryotes, eukaryotes and viruses (RefSeq release 49, September 2011). The RefSeq database is maintained by a combined approach of automated analyses, collaboration and manual curation to generate an up-to-date representation of the sequence, its features, names and cross-links to related sources of information. We report here on recent growth, the status of curating the human RefSeq data set, more extensive feature annotation and current policy for eukaryotic genome annotation via the NCBI annotation pipeline. More information about the resource is available online (see http://www.ncbi.nlm.nih.gov/RefSeq/).

  3. Policy, economic, and industry repercussions of current e-business diffusion rate In European food industry

    OpenAIRE

    Vlachos, Ilias

    2005-01-01

    European policy is focussed on promoting the business techniques and new ways of working which will provide the economic and social foundation of the information society in Europe. To help policy makers define their programmes, and to monitor the effectiveness of these policies, it is essential to examine progress as well as identify areas requiring active support. This study examined the repercussions of e-business progress in the food sector based on the findings of a large quantitative sur...

  4. INVASIVE CANDIDA INFECTIONS IN PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES AND HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS: CURRENT EPIDEMIOLOGY AND THERAPEUTIC OPTIONS.

    Directory of Open Access Journals (Sweden)

    Corrado Girmenia

    2011-03-01

    Full Text Available In the last decades, the global epidemiological impact of invasive candidiasis (IC in patients with hematologic malignancies (HM and in hematopoietic stem cell transplant (HSCT recipients has decreased and the incidence of invasive aspergillosis  exceeded that of Candida infections. The use of prevention strategies, first of all antifungal prophylaxis with triazoles,  contributed to the reduction of IC in these populations as demonstrated by several  epidemiological studies. However, relatively little is known about the current epidemiological patterns of IC in HM and HSCT populations, because recent epidemiological data almost exclusively derive from retrospective experiences and few prospective data are available. Several prospective, controlled studies in the prophylaxis of invasive fungal diseases have been conducted in both the HM and HSCT setting. On the contrary, most of the prospective controlled trials that demonstrated the efficacy of the antifungal drugs echinocandins and voriconazole in the treatment of candidemia and invasive candidiasis mainly involved  patients with underlying conditions other than HM or  HSCT.  For these reasons, international guidelines provided specific indications for the prophylaxis strategies in HM and HSCT patients, whereas the  recommendations on therapy of documented Candida infections are based on the results observed in the general population and should be considered with caution.

  5. Report on Current Praxis of Policies and Activities Supporting Societal Engagement in Research and Innovation

    NARCIS (Netherlands)

    Kuhn, Rainer; Mbungu, Grace; Anderson, Edward; Chonkova, Blagovesta; Damianova, Zoya; Davis, Houda; Dencker, Siri; Jørgensen, Marie-Louise; Kozarev, Ventseslav; Larsen, Gy; Mulder, Henk; Pfersdorf, Simon

    2014-01-01

    The aim of the “Engage2020 Project” 1 is to promote the use of engagement methods and policies that support societal engagement in research and innovation by mapping what is practiced and spreading awareness of the opportunities amongst researchers, policy makers, and other interested parties. The

  6. Report on Current Praxis of Policies and Activities Supporting Societal Engagement in Research and Innovation

    NARCIS (Netherlands)

    Kuhn, Rainer; Mbungu, Grace; Anderson, Edward; Chonkova, Blagovesta; Damianova, Zoya; Davis, Houda; Dencker, Siri; Jørgensen, Marie-Louise; Kozarev, Ventseslav; Larsen, Gy; Mulder, Henk; Pfersdorf, Simon

    2014-01-01

    The aim of the “Engage2020 Project” 1 is to promote the use of engagement methods and policies that support societal engagement in research and innovation by mapping what is practiced and spreading awareness of the opportunities amongst researchers, policy makers, and other interested parties. The p

  7. The National Bank of Romania monetary policy characteristics in addition to the current financial crisis

    OpenAIRE

    Stefan Sambotin; Andreea Bucur

    2012-01-01

    Considering the starting point for research the Central Bank key role in economic life, through the implementation of the monetary policy, by exercising prudential control and supervision of commercial banks, the present paper proposes an analysis of the National Bank of Romania monetary policy coordinates in the frame of the increased intensification harsh effects of the global economic crisis.

  8. Expert involvement in policy development: A systematic review of current practice

    NARCIS (Netherlands)

    Fischer, A.R.H.; Wentholt, M.T.A.; Rowe, E.J.; Frewer, L.J.

    2014-01-01

    In what ways are experts involved in policy development, and with what results? This paper attempts to answer these questions through a structured review of the academic literature, focusing on the identification of ‘methodologies’ of expert involvement, and on analying the subsequent policy impact

  9. Women's Views about Gender Equality on the Current Social Policy in Turkey

    Science.gov (United States)

    Öztop, Hülya; Finkel, Müge

    2015-01-01

    Women's equal participation in all aspects of social, political and economic life is an essential requirement for sustainable development and democratic governance. How to engage women in these different spheres of policy, increase their access to information and ensure their participation in policy debates are therefore among the key questions…

  10. The National Bank of Romania monetary policy characteristics in addition to the current financial crisis

    Directory of Open Access Journals (Sweden)

    Stefan Sambotin

    2012-12-01

    Full Text Available Considering the starting point for research the Central Bank key role in economic life, through the implementation of the monetary policy, by exercising prudential control and supervision of commercial banks, the present paper proposes an analysis of the National Bank of Romania monetary policy coordinates in the frame of the increased intensification harsh effects of the global economic crisis.

  11. Current information gaps in micronutrient research, programs and policy: how can we fill them?

    Science.gov (United States)

    Micronutrient (MN) interventions have a very positive effect on public health and have been a major focus of nutrition research and policy for over 3 decades. Most MN policies are established by the World Health Organization based on available evidence from well-designed trials. These include recomm...

  12. Current practices and future opportunities for policy on climate change and invasive species.

    Science.gov (United States)

    Pyke, Christopher R; Thomas, Roxanne; Porter, Read D; Hellmann, Jessica J; Dukes, Jeffrey S; Lodge, David M; Chavarria, Gabriela

    2008-06-01

    Climate change and invasive species are often treated as important, but independent, issues. Nevertheless, they have strong connections: changes in climate and societal responses to climate change may exacerbate the impacts of invasive species, whereas invasive species may affect the magnitude, rate, and impact of climate change. We argue that the design and implementation of climate-change policy in the United States should specifically consider the implications for invasive species; conversely, invasive-species policy should address consequences for climate change. The development of such policies should be based on (1) characterization of interactions between invasive species and climate change, (2) identification of areas where climate-change policies could negatively affect invasive-species management, and (3) identification of areas where policies could benefit from synergies between climate change and invasive-species management.

  13. Idaho's Energy Options

    Energy Technology Data Exchange (ETDEWEB)

    Robert M. Neilson

    2006-03-01

    This report, developed by the Idaho National Laboratory, is provided as an introduction to and an update of the status of technologies for the generation and use of energy. Its purpose is to provide information useful for identifying and evaluating Idaho’s energy options, and for developing and implementing Idaho’s energy direction and policies.

  14. Eco-design of Steel Industry and Policy Options in China%钢铁产业生态化设计与政策选择

    Institute of Scientific and Technical Information of China (English)

    张雅

    2012-01-01

    钢铁产业是国民经济重要的支柱产业,也是典型的高能耗、高排放、高污染产业.钢铁产业生态化设计与政策选择是落实科学发展现,推动生态文明建设,加快转变经济发展方式的必然要求.以烧结(球团)、焦化、炼铁,炼钢、轧钢工序中节能减排、污染防治和落后生产能力淘汰为重点,以环境影响评价为导向,基于钢铁全生产流程物质流分析,融入循环经济和清洁生产理念,以新型节能清洁工艺技术、装备技术和仿真、信息化技术的开发应用为切入点,融入生态文明、循环经济和清洁生产理念,完善钢铁生态产业链,加强资源综合利用,强化生态技术创新.本文从市场引导、政策促进、环境监管、技术创新、过程控制、内部循环、外部联合、责任延伸、行业自律、公众参与等10个层面,构建促进钢铁产业生态化的政策体系,充分发挥政府、企业、行业、中介组织、金融机构和社会公众的作用,在规划、机制和技术层次上全面落实钢铁产业生态化政策,全面推动我国钢铁产业的转型升级和绿色发展.%The steel industry is an important pillar industry of national economy, and is also the typical industry of high energy consumption, high emission, and high-pollution. Eco-design and policy options in the steel industry are to implement the scientific concept of development, and the construction of ecological civilization. It is an inevitable requirement to accelerate the transformation of economic development. In the process of sintering (pellets), coking, iron making, steelmaking and steel rolling, energy saving, pollution control and eliminating backward production capability are important. Based on environmental impact assessment and the steel production process of material flow analysis, we integrate the concept of circular economy and green production, focus on the new energy-saving technology and development and

  15. The Legality of Japan’s Current Monetary Policy under International Law

    National Research Council Canada - National Science Library

    John Riley

    2014-01-01

    In response to the 2008 global financial crisis, many of the world’s largest central banks initiated unconventional monetary policies such as quantitative easing when standard open market operations became ineffective...

  16. Chronic Constipation: Current Treatment Options

    Directory of Open Access Journals (Sweden)

    Louis Wing Cheong Liu

    2011-01-01

    Full Text Available Chronic constipation is a common functional gastrointestinal disorder that affects patients of all ages. In 2007, a consensus group of 10 Canadian gastroenterologists developed a set of recommendations pertaining to the management of chronic constipation and constipation-dominant irritable bowel syndrome. Since then, tegaserod has been withdrawn from the Canadian market. A new, highly selective serotonin receptor subtype 4 agonist, prucalopride, has been examined in several large, randomized, placebo-controlled trials demonstrating its efficacy and safety in the management of patients with chronic constipation. Additional studies evaluating the use of stimulant laxatives, polyethylene glycol and probiotics in the management of chronic constipation have also been published. The present review summarizes the previous recommendations and new evidence supporting different treatment modalities – namely, diet and lifestyle, bulking agents, stool softeners, osmotic and stimulant laxatives, prucalopride and probiotics in the management of chronic constipation. A brief summary of lubiprostone and linaclotide is also presented. The quality of evidence is presented by adopting the Grading of Recommendations, Assessment, Development and Evaluation system. Finally, a management pyramid for patients with chronic constipation is proposed based on the quality of evidence, impact of each modality on constipation and on general health, and their availabilities in Canada.

  17. Monetary policy, financial intermediation, current account and housing market - how do they fit together?

    OpenAIRE

    Stanimira Milcheva

    2012-01-01

    We estimate the role of monetary policy, net capital inflow and credit supply shocks for house prices, residential investment and durable consumption. These fundamental shocks account for three leading hypotheses about the causes of the recent housing bubble in the US: loose monetary policy, a `global saving glut' and loose credit standards for mortgage borrowers. Shocks in credit standards are stemming from variations in the assets of security broker-dealers, as these channel the securitized...

  18. The current status of the debate on socio-economic regulatory assessments: positions and policies in Canada, the USA, the EU and developing countries

    NARCIS (Netherlands)

    Falck-Zepeda, J.; Wesseler, J.H.H.; Smyth, S.

    2013-01-01

    Article 26.1 of the Cartagena Protocol on Biosafety has the option of considering socio-economic issues in biosafety regulatory approval processes related to genetically engineered organisms. National laws and regulations in some countries have already defined positions and may have enacted policies

  19. A public-policy practicum to address current issues in human, animal, and ecosystem health.

    Science.gov (United States)

    Herrmann, John A; Johnson, Yvette J; Troutt, H Fred; Prudhomme, Thomas

    2009-01-01

    There are recognized needs for cross-training health professionals in human, animal, and ecosystem health and for public health policy to be informed by experts from medical, science, and social science disciplines. Faculty members of the Community Health and Preventive Medicine Section at the University of Illinois at Urbana-Champaign, College of Veterinary Medicine, and the Institute of Government and Public Affairs, University of Illinois at Urbana-Champaign, have offered a public-policy course designed to meet those needs. The course was designed as a practicum to teach students the policy-making process through the development of policy proposals and to instruct students on how to effectively present accurate scientific, demographic, and statistical information to policy makers and to the public. All students substantially met the learning objectives of the course. This course represents another model that can be implemented to help students learn about complex, multifactorial issues that affect the health of humans, animals, and ecosystems, while promoting participation in public health policy development.

  20. Current salt reduction policies across gradients of inequality-adjusted human development in the WHO European region: minding the gaps.

    Science.gov (United States)

    Rodriguez-Fernandez, Rodrigo; Siopa, Margarida; Simpson, Sarah J; Amiya, Rachel M; Breda, Joao; Cappuccio, Francesco P

    2014-08-01

    To assess current salt reduction policies in countries of the WHO European Region against the backdrop of varying levels of human development adjusted for income, education and health (longevity) inequalities. Population-based, cross-sectional study, with data gathered through systematic review of relevant databases and supplementary information provided by WHO Nutrition Counterparts. Member States of the WHO European Region. Inequality-adjusted Human Development Index scores were analysed against assessed levels of development and implementation of national nutrition policies and initiatives targeting population-level salt reduction. Within the WHO European Region, Inequality-adjusted Human Development Index values among countries with no existing salt reduction initiatives (mean 0·643 (se 0·022)) were significantly lower than among those with either partially implemented/planned salt initiatives (mean 0·766 (se 0·017), P < 0·001) or fully implemented salt initiatives (mean 0·780 (se 0·021), P < 0·001). Where salt reduction strategies are implemented as an integral part of national policy, outcomes have been promising. However, low- and middle-income countries may face severe resource constraints that keep them from emulating more comprehensive strategies pursued in high-income countries. Care must be taken to ensure that gaps are not inadvertently widened by monitoring differential policy impacts of salt policies, particularly regarding trade flows.

  1. Fusion, cold fusion, and space policy

    Energy Technology Data Exchange (ETDEWEB)

    Rotegard, D. (CST Ltd. (United States))

    1991-01-01

    This paper critiques Americal science policy through a consideration of two examples-cold fusion and asteroid mining. It points out that the failure of central planning in science and technology policy is just as marked as in more mundane activities. It highlights the current low level of debate and points out some technical issues that need to be addressed. It concludes with evidence that the alliance of flawed policy options is further lowering the level of debate. (author).

  2. Integrated primary health care in Greece, a missing issue in the current health policy agenda: a systematic review

    Directory of Open Access Journals (Sweden)

    Christos Lionis

    2009-07-01

    Full Text Available Background: Over the past years, Greece has undergone several endeavors aimed at modernizing and improving national health care services with a focus on PHC. However, the extent to which integrated primary health care has been achieved is still questioned. Purpose: This paper explores the extent to which integrated primary health care (PHC is an issue in the current agenda of policy makers in Greece, reporting constraints and opportunities and highlighting the need for a policy perspective in developing integrated PHC in this Southern European country. Methods: A systematic review in PubMed/Medline and SCOPUS, along with a hand search in selected Greek biomedical journals was undertaken to identify key papers, reports, editorials or opinion letters relevant to integrated health care. Results: Our systematic review identified 198 papers and 161 out of them were derived from electronic search. Fifty-three papers in total served the scope of this review and are shortly reported. A key finding is that the long-standing dominance of medical perspectives in Greek health policy has been paving the way towards vertical integration, pushing aside any discussions about horizontal or comprehensive integration of care. Conclusion: Establishment of integrated PHC in Greece is still at its infancy, requiring major restructuring of the current national health system, as well as organizational culture changes. Moving towards a new policy-based model would bring this missing issue on the discussion table, facilitating further development.

  3. The global momentum for smokefree public places: best practice in current and forthcoming smokefree policies

    Directory of Open Access Journals (Sweden)

    BA G Griffith

    2008-01-01

    Full Text Available The Global Smokefree Partnership has recently prepared a map of smokefree campaigns and policies around the world. It focuses primarily on countries that are parties to the WHO Framework Convention on Tobacco Control, but other countries were included. The smokefree status of 172 countries was mapped. Of these countries, 31 (18.0% have established comprehensive smokefree policies, either nationally or at state or city level - best practice; 25 (14.6% are planning to implement smokefree policies in 2008 or 2009; and 51(29.6% are making significant progress with smokefree policies. Only 65 countries (37.8% have limited or no smokefree polices. A selection of countries representing best practices in smokefree policies or planning to implement smokefree policies in 2008 or 2009 is highlighted. They illustrate the significant global momentum for smokefree policies, the success of established policies, the importance of civil society and the sharing of experience between countries.El Global Smokefree Partnership recién completó un mapa de las campañas para promover políticas de ambientes libres de humo (ALH a nivel mundial. El mapa se centra en los países Partes al Convenio Marco para el Control del Tabaco de la OMS, aunque otros países también se incluyen, y documenta el estatus de 172 países en el tema de los ALH. De estos países, 31 (18.0% tienen políticas comprehensivas de ALH, a nivel nacional, provincial, y/o estatal - mejores prácticas; 25 (14.6% prevén la implementación de políticas de ALH en 2008 o 2009; y 51 (29.6% han progresado significativamente con estas políticas. Sólo 65 países (37.8% no tienen políticas de ALH, o sólo políticas limitadas en este ámbito. Este ensayo destaca una selección de países que representan las mejores prácticas en las políticas de ALH o que prevén la implementación de estas políticas en 2008 o 2009, con tal de ilustrar el movimiento global hacia los ambientes libres de humo; el

  4. Information Infrastructure Development Recommendations through Analysis of Current Information Technology Infrastructure, Plans and Policies

    Science.gov (United States)

    2007-11-02

    information society , and the military influence on information and communication technologies development; a review of the policy, objectives, concepts and methods, and the resources outlined in the Information Technology Management Strategic Plan, the Defense Information Infrastructure Master Plan, and the Global and National Information Infrastructure

  5. The Medicalization of Current Educational Research and Its Effects on Education Policy and School Reforms

    Science.gov (United States)

    Tröhler, Daniel

    2015-01-01

    This paper starts from the assumption of the emergence of an educationalized culture over the last 200 years according to which perceived social problems are translated into educational challenges. As a result, both educational institutions and educational research grew, and educational policy resulted from negotiations between professionals,…

  6. Plastic debris and policy: Using current scientific understanding to invoke positive change

    NARCIS (Netherlands)

    Rochman, Chelsea M.; Cook, A.M.; Koelmans, A.A.

    2016-01-01

    Captain Charles Moore introduced the world to the "Great Pacific Garbage Patch" in the mid-1990s. Since then, there has been increasing interest from scientists, the public and policy makers regarding plastic debris in the environment. A focus article in the July issue of the Society of

  7. Valuation of Drug Abuse: A Review of Current Methodologies and Implications for Policy Making

    Science.gov (United States)

    Schori, Maayan

    2011-01-01

    This article reviews the use of several valuation methods as they relate to drug abuse and places them within the context of U.S. policy. First, cost-of-illness (COI) studies are reviewed and their limitations discussed. Second, three additional economic methods of valuing drug abuse are reviewed, including cost-effectiveness analysis (CEA),…

  8. Valuation of Drug Abuse: A Review of Current Methodologies and Implications for Policy Making

    Science.gov (United States)

    Schori, Maayan

    2011-01-01

    This article reviews the use of several valuation methods as they relate to drug abuse and places them within the context of U.S. policy. First, cost-of-illness (COI) studies are reviewed and their limitations discussed. Second, three additional economic methods of valuing drug abuse are reviewed, including cost-effectiveness analysis (CEA),…

  9. Policies for patient access to clinical data via PHRs: current state and recommendations.

    Science.gov (United States)

    Collins, Sarah A; Vawdrey, David K; Kukafka, Rita; Kuperman, Gilad J

    2011-12-01

    Healthcare delivery organizations are increasingly using online personal health records (PHRs) to provide patients with direct access to their clinical information; however, there may be a lack of consistency in the data made available. We aimed to understand the general use and functionality of PHRs and the organizational policies and decision-making structures for making data available to patients. A cross-sectional survey was administered by telephone structured interview to 21 organizations to determine the types of data made available to patients through PHRs and the presence of explicit governance for PHR data release. Organizations were identified based on a review of the literature, PHR experts, and snowball sampling. Organizations that did not provide patients with electronic access to their data via a PHR were excluded. Interviews were conducted with 17 organizations for a response rate of 81%. Half of the organizations had explicit governance in the form of a written policy that outlined the data types made available to patients. Overall, 88% of the organizations used a committee structure for the decision-making process and included senior management and information services. All organizations sought input from clinicians. Discussion There was considerable variability in the types of clinical data and the time frame for releasing these data to patients. Variability in data release policies may have implications for PHR use and adoption. Future policy activities, such as requirement specification for the latter stages of Meaningful Use, should be leveraged as an opportunity to encourage standardization of functionality and broad deployment of PHRs.

  10. Student Loan Debt and Economic Outcomes. Current Policy Perspective No. 14-7

    Science.gov (United States)

    Cooper, Daniel; Wang, J. Christina

    2014-01-01

    This policy brief advances the growing literature on how student loan debt affects individuals' other economic decisions. Specifically, it examines the impact of student loan liabilities on individuals' homeownership status and wealth accumulation. The analysis employs a rich set of financial and demographic control variables that are not…

  11. Learning Disabilities: Current Policy and Directions for Community Involvement among the Arab Community in Israel

    Science.gov (United States)

    Jabareen-Taha, Samaher; Taha, Haitham

    2016-01-01

    This article seeks to identify and review the basic characteristics of learning disability which are specifically mentioned in the literature. In addition, the article intends to conduct a brief analysis on learning disability policy in Israel and the differentiation problems at the level of awareness among the Arab society in Israel. Despite the…

  12. Extended Deterrence: Taking Stock of Current Policy and Updating the Research and PME Agendas

    Science.gov (United States)

    2014-08-01

    economic policy and leadership in global governance has diminished. The BRIC countries (Brazil, Russia, India and China) are now challenging US...Monetary Fund has given the BRICs incentives to establish parallel institutions. The United States must find ways to maneuver more effectively in an

  13. Approximate option pricing

    Energy Technology Data Exchange (ETDEWEB)

    Chalasani, P.; Saias, I. [Los Alamos National Lab., NM (United States); Jha, S. [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    1996-04-08

    As increasingly large volumes of sophisticated options (called derivative securities) are traded in world financial markets, determining a fair price for these options has become an important and difficult computational problem. Many valuation codes use the binomial pricing model, in which the stock price is driven by a random walk. In this model, the value of an n-period option on a stock is the expected time-discounted value of the future cash flow on an n-period stock price path. Path-dependent options are particularly difficult to value since the future cash flow depends on the entire stock price path rather than on just the final stock price. Currently such options are approximately priced by Monte carlo methods with error bounds that hold only with high probability and which are reduced by increasing the number of simulation runs. In this paper the authors show that pricing an arbitrary path-dependent option is {number_sign}-P hard. They show that certain types f path-dependent options can be valued exactly in polynomial time. Asian options are path-dependent options that are particularly hard to price, and for these they design deterministic polynomial-time approximate algorithms. They show that the value of a perpetual American put option (which can be computed in constant time) is in many cases a good approximation to the value of an otherwise identical n-period American put option. In contrast to Monte Carlo methods, the algorithms have guaranteed error bounds that are polynormally small (and in some cases exponentially small) in the maturity n. For the error analysis they derive large-deviation results for random walks that may be of independent interest.

  14. Global health equity in United Kingdom university research: a landscape of current policies and practices.

    Science.gov (United States)

    Gotham, Dzintars; Meldrum, Jonathan; Nageshwaran, Vaitehi; Counts, Christopher; Kumari, Nina; Martin, Manuel; Beattie, Ben; Post, Nathan

    2016-10-10

    Universities are significant contributors to research and technologies in health; however, the health needs of the world's poor are historically neglected in research. Medical discoveries are frequently licensed exclusively to one producer, allowing a monopoly and inequitable pricing. Similarly, research is often published in ways that make it inaccessible. Universities can adopt policies and practices to overcome neglect and ensure equitable access to research and its products. For 25 United Kingdom universities, data on health research funding were extracted from the top five United Kingdom funders' databases and coded as research on neglected diseases (NDs) and/or health in low- and lower-middle-income countries (hLLMIC). Data on intellectual property licensing policies and practices and open-access policies were obtained from publicly available sources and by direct contact with universities. Proportions of research articles published as open-access were extracted from PubMed and PubMed Central. Across United Kingdom universities, the median proportion of 2011-2014 health research funds attributable to ND research was 2.6% and for hLLMIC it was 1.7%. Overall, 79% of all ND funding and 74% of hLLMIC funding were granted to the top four institutions within each category. Seven institutions had policies to ensure that technologies developed from their research are affordable globally. Mostly, universities licensed their inventions to third parties in a way that confers monopoly rights. Fifteen institutions had an institutional open-access publishing policy; three had an institutional open-access publishing fund. The proportion of health-related articles with full-text versions freely available online ranged from 58% to 100% across universities (2012-2013); 23% of articles also had a creative commons CC-BY license. There is wide variation in the amount of global health research undertaken by United Kingdom universities, with a large proportion of total research

  15. APA guidelines: their importance and a plan to keep them current: 2013 annual report of the Policy and Planning Board.

    Science.gov (United States)

    2014-01-01

    When guidelines are approved by APA, they become association policy, and it is imperative that they remain current. The revision of guidelines poses several challenges to the association. These challenges range from the availability and allocation of resources to support the complicated processes involved in developing and updating these policies to the lack of a clearly defined process that includes identification of tasks, assignments of responsibilities, and so forth. For this reason, the APA Board of Directors asked the Policy and Planning Board (P&P) to work with the boards of the four directorates (i.e., the Education Directorate, the Practice Directorate, the Public Interest Directorate, and the Science Directorate) to create a proposal that would (a) make recommendations with regard to how the review and revision of guidelines documents might best be accomplished in accordance with the APA Strategic Plan and existing policies and procedures and (b) make suggestions regarding the association resources that might be required. The Board of Directors approved the proposed review process in December 2013. 2014 APA, all rights reserved

  16. Haiti: Developments and U.S. Policy Since 1991 and Current Congressional Concerns

    Science.gov (United States)

    2007-08-30

    Narcotics Control Strategy Report (INCSR), which maintained that Haiti is a major transit country for cocaine from South America because of its weak... football game in August.42 Haiti’s Chief of Police, Mario Andresol, announced a policy of “zero tolerance” for police involvement in criminal...with arms from those shipped and held since 2005. Narcotics Trafficking Haiti is a “key conduit” for cocaine being transported from South America to the

  17. U.S.-Vietnam Relations in 2011: Current Issues and Implications for U.S. Policy

    Science.gov (United States)

    2012-05-18

    a policy of neutrality on the claims by the parties, which also include Brunei, Indonesia, Malaysia , the Philippines, and Taiwan. Throughout 2009...territorial disputes. Roughly one and a half times the size of the Mediterranean Sea, it is ringed by China, Vietnam, Malaysia , Indonesia, Brunei...government to monitor data processed by these companies and/or more susceptible to government pressure on issues such as censorship .36 Many of the

  18. The Institutionalization of Universal Health Policy in Costa Rica and Current Challenges

    OpenAIRE

    2013-01-01

    Objective: To analyze the role of the Ministry of Health in Costa Rican public policy. Methods: The analysis is a case study comparing two periods (1950 - 1990 and 1990 - 2010) using qualitative data collection instruments, including review of literature and institutional documents as well as in-depth interviews and focus group discussions, all with data triangulation. Results: The analysis found important differences between two periods: before the 1990s,consecutive governments were strongly...

  19. The Institutionalization of Universal Health Policy in Costa Rica and Current Challenges

    OpenAIRE

    Jorine Muiser

    2013-01-01

    Objective: To analyze the role of the Ministry of Health in Costa Rican public policy. Methods: The analysis is a case study comparing two periods (1950 - 1990 and 1990 - 2010) using qualitative data collection instruments, including review of literature and institutional documents as well as in-depth interviews and focus group discussions, all with data triangulation. Results: The analysis found important differences between two periods: before the 1990s,consecutive governments were strongly...

  20. The Evolving Arctic: Current State of U.S. Arctic Policy

    Science.gov (United States)

    2013-09-01

    obvious that improvements need to be made to guard U.S. interests While the U.S. procrastinates in taking its rightful place in the Arctic, Russia...foreign policy priority.87 1. Exercising Arctic Sovereignty As an Arctic nation, Canada firmly understands the importance of ensuring and...domain awareness in the region.88 In May 2010, Canadian and Danish military leaders signed a memorandum of understanding on Arctic defense, security

  1. HOW IS CURRENT PHARMACEUTICALS PRICING POLICY ON GENERICS PERFORMING IN TURKEY REGARDING PRICE EROSION?

    Directory of Open Access Journals (Sweden)

    Kadir GÜRSOY

    2017-02-01

    Full Text Available Generics are commonly accepted to contribute significantly to treating disease by improving the affordability of pharmaceuticals. Once the patent expires for an originator brand, generics erode prices through creating fierce competition. The objective of this study is to investigate on Turkish pharmaceutical policies over generics through measuring how much they lower the prices, and then develop alternative strategies to maintain higher level of price reduction, and hence saving. Claims data from Turkish Social Security Institution (SSI for all ambulatory care drugs reimbursed were collected monthly in the period of January 2009 to December 2013 and for selected 12 equivalent groups price erosion and saving impacts due to generic entry be computed. Moreover, the price erosion for 15 generics entering the reimbursement list in 2012 as first generics was measured. For 12 equivalent groups constituting nearly 7% of SSI drug spending, the price erosion was nearly 41% ranging from 8% to 74%. In the first year of the first generic entry, on average the prices were only shrank by 39% with an increase of 41% in units sold. As a result of those analyses, it is concluded that Turkey is not maximizing its full potential with respect to generic medicines. Therefore, it is of great importance that policies such as therapeutic equivalence, tendering, and aggressive generic pricing policy to stimulate higher savings need to be introduced in the near future.

  2. The Current Evolution of Slavic Languages in Central and Eastern Europe in the Context of the EU Multilingualism Policy

    Directory of Open Access Journals (Sweden)

    Wojciech Paweł Sosnowski

    2015-12-01

    Full Text Available The Current Evolution of Slavic Languages in Central and Eastern Europe in the Context of the EU Multilingualism Policy The respect for and protection of cultural and linguistic diversity have long been guaranteed in various international and European legislative acts. More recently, the European Union has also developed laws aimed at the preservation and promotion of multilingualism. Linguistic diversity has long been seen as an obstacle to the effective functioning of EU institutions. Recently, however, it has been considered as a valuable “heritage” of the EU. In our article, we will present a brief overview of policies promoting multilingualism in Europe, and more specifically, in the EU. Subsequently, we will compare this framework to the changes occurring presently in modern Slavic languages of Central and Eastern Europe. The tendency of these languages towards increased analitism transforms these predominantly synthetic languages into more analytical ones. These conclusions have led us to the following question: What is the current state of modern Slavic languages and how far may their evolution be addressed by policies promoting multilingualism? Our analysis consists of two parts: first, we scrutinised various European legislative acts promoting multilingualism; second, we analysed modern Slavic languages by means of the parallel corpora of chosen languages from the Common Language Resources and Technology Infrastructure project (including UNESCO and EU legislation, etc..

  3. Expensing options solves nothing.

    Science.gov (United States)

    Sahlman, William A

    2002-12-01

    The use of stock options for executive compensation has become a lightning rod for public anger, and it's easy to see why. Many top executives grew hugely rich on the back of the gains they made on their options, profits they've been able to keep even as the value they were supposed to create disappeared. The supposed scam works like this: Current accounting regulations let companies ignore the cost of option grants on their income statements, so they can award valuable option packages without affecting reported earnings. Not charging the cost of the grants supposedly leads to overstated earnings, which purportedly translate into unrealistically high share prices, permitting top executives to realize big gains when they exercise their options. If an accounting anomaly is the problem, then the solution seems obvious: Write off executive share options against the current year's revenues. The trouble is, Sahlman writes, expensing option grants won't give us a more accurate view of earnings, won't add any information not already included in the financial statements, and won't even lead to equal treatment of different forms of executive pay. Far worse, expensing evades the real issue, which is whether compensation (options and other-wise) does what it's supposed to do--namely, help a company recruit, retain, and provide the right people with appropriate performance incentives. Any performance-based compensation system has the potential to encourage cheating. Only ethical management, sensible governance, adequate internal control systems, and comprehensive disclosure will save the investor from disaster. If, Sahlman warns, we pass laws that require the expensing of options, thinking that's fixed the fundamental flaws in corporate America's accounting, we will have missed a golden opportunity to focus on the much more extensive defects in the present system.

  4. Carbon in soils as an option for climate policy. Carbon stock in Dutch soils and influence options; Koolstof in de bodem als optie voor klimaatbeleid. Voorraad koolstof in Nederlandse bodem en beinvloedingsmogelijkheden

    Energy Technology Data Exchange (ETDEWEB)

    Kuikman, P.J.; De Groot, W.J.M.; Hendriks, R.F.A.; Verhagen, J.; De Vries, F. [Alterra, Green World Research, Wageningen (Netherlands)

    2003-10-01

    Considerations are presented for the choice of options to calculate and monitor stocks of C in all soils and emissions of CO2 from agricultural soils in the Netherlands for the Kyoto 1990 baseline and following years. The objective of the study was to prepare data for a national submission according to the Common Reporting Format for C stocks on specific land uses, land use changes en C fluxes according to article 5.2 in the Kyoto Protocol. In this article we report on the whereabouts of the C stocks in order to be geographically explicit, discuss the uncertainties in the inventory and analyse future inventory options. Modeling approaches (e.g. CESAR) where other parameters, process-oriented (fluxes), uncertainty measure can be added are discussed. [Dutch] Milieukundigen rekenen er sinds het Kyoto-protocol op dat de bodem ook als opsIagplaats van koolstof kan dienen. Veeial gaat men er als vanzelfsprekend van uit dat de opsiag van koolstof in bodems van bossen blijvend is en er onbeperkte voorraden kunnen worden aangelegd. Dat is onterecht. In Nederland is onlangs een eerste berekening gemaakt van de voorraad koolstof.

  5. Management of third stage labour following vaginal birth in Iran: a survey of current policies.

    Science.gov (United States)

    Afshari, Poorandokht; Medforth, Janet; Aarabi, Mohsen; Abedi, Parvin; Soltani, Hora

    2014-01-01

    this study was aimed to provide information on policies for the practice of managing the third stage of labour in Iran, including discussion of related systematic evidence. this survey used a standard questionnaire to obtain information about prevention and early treatment of postpartum haemorrhage from all geographical areas in Iran, in 2010. the survey included maternity units from 23 provinces, covering 129 out of a total of 560 maternity units in Iran. at least one public hospital, one private hospital and one rural birth facility unit were included from each province. Questionnaires were completed by the unit's senior midwife with support from the unit's lead obstetrician. all the units who were approached responded to the study including 69 public hospitals, 32 private hospitals and 28 rural birth facility units. The rate of active management of the third stage of labour was 57 per cent, although answers to individual components of management indicated a higher rate for active interventions than expectant management. Ninety-four per cent of the responding centres indicated oxytocin administration, 71 per cent apply early cord clamping and 65 per cent apply controlled cord traction. A lack of standard definition for postpartum haemorrhage was reported in 18 per cent of units. a high rate of active management was reported in Iran with variation in its different components which is in line with the international findings. These policies were mainly congruent with the existing systematic evidence except for timing of cord clamping. there is a need for improvement in locally sensitive policy development, continuing education, establishing accurate auditing systems and ensuring access to facilities such as blood banks and products in rural units. Efforts to reduce maternal mortality and morbidity and investigations into their causes should be extended to factors beyond the third stage of labour care clinical components. Crown Copyright © 2013. Published by

  6. The Value of CCS under Current Policy Scenarios: NDCs and Beyond

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, Casie L.; Dahowski, Robert T.; McJeon, Haewon C.; Clarke, Leon E.; Iyer, Gokul C.; Muratori, Matteo

    2017-07-01

    This paper describes preliminary results of analysis using the Global Change Assessment Model (GCAM) to evaluate the potential role of CCS in addressing emissions reduction targets. Scenarios are modelled using the Paris-Increased Ambition (PIA) case developed by Fawcett et al. (2015), and a more aggressive Paris Two-Degree Ambition (P2A) case. Both cases are based upon nationally determined contributions (NDCs) agreed to at the UNFCCC Conference of Parties (COP-21) in December 2015, coupled with additional mitigation effort beyond the 2030 Paris timeframe, through the end of the century. Analysis of CCS deployment and abatement costs under both policy scenarios suggests that, as modelled, having CCS in the technological portfolio could reduce the global cost of addressing emissions reduction targets specified under the policy scenario by trillions of dollars, primarily by enabling a smoother and lower-cost transition to next-generation technologies. Through the end of the century, total global abatement costs associated with the PIA case – with five percent annual reduction in emission intensity and reaching 2.2 degrees by 2100 – are reduced by $15 trillion USD in the scenario where CCS is available to deploy by 2025 and remains available through 2100, reflecting a 47 percent savings in the cost of climate change abatement. Under the more ambitious P2A case, with 8 percent annual reduction in emission intensity and reaching 1.9 degrees by 2100, the availability of CCS reduces global abatement costs by $22 trillion USD through the end of the century, again nearly halving the costs of addressing the policy, relative to achieving the same target using an energy portfolio that does not include CCS. PIA and P2A scenarios with CCS result in 1,250 and 1,580 GtCO2 of global geologic storage by the end of the century, respectively.

  7. The absorption of UE funds in the current context of the cohesion policy

    Directory of Open Access Journals (Sweden)

    Dumitrescu, A.

    2011-01-01

    Full Text Available Romania continues to be affected by the global recession. It has suffered a significant reduction in foreign investment since the start of the recession, as investors have moved away from emerging markets in search for security. Developing an appropriate, focused strategy for the allocation of EU funds is only the first, though perhaps the most important step in implementing the EU cohesion policy. The successful implementation of EU co-funded projects is contingent not only upon the effectiveness of these countries’ administrative systems, but also on the activity of the potential beneficiaries.

  8. INDIA’S FOREIGN DIRECT INVESTMENT: CURRENT STATUS, ISSUES AND POLICY RECOMMENDATIONS

    Directory of Open Access Journals (Sweden)

    Mukesh Ranga

    2010-12-01

    Full Text Available Foreign Direct Investment (FDI as an important driver of growth. It is an important source of non debt financial resources for country for economic development. Besides it is a means of achieving technical know-how and employment generation of employment. However, many are of the view that FDI is a big threat to sovereignty of host and domestic business houses. Faster exploitation of natural resources for profit may deprive host from such resources in long run. Midst of debate on pros and cons of FDI, world economy has observed a phenomenal change in volume and pattern of FDI. There is clearly an intense global competition of FDI. India is not behind this global race of attracting foreign investment. India emerged as an attractive FDI destination in services but has failed to evolve a manufacturing hub which has greater economic benefit. FDI though one of the important sources of financing the economic development, but not is not a solution for poverty eradication, unemployment and other economic ills. India needs a massive investment to achieve the goals of vision 20-20. Policy makers need to ensure transparency and consistency in policy making along with comprehensive long term development strategy.

  9. African policy of Delhi and Indian community in Africa: current status

    Directory of Open Access Journals (Sweden)

    Vyacheslav Alexandrovich Usov

    2016-12-01

    Full Text Available The article is devoted to a changing nature of India-Africa relations and a role of Indian Diaspora in Africa. Indian Diaspora in African countries for many years was regarded by the Indian government more as a stumbling block for development India-Africa relations than as a source of opportunities. New policy to Diaspora was elaborated in the very beginning of 2000s but it was Narendra Modi, Indian prime-minister from 2014, who started promoting Diaspora as one of the priority in his international agenda. Indian government initiated in October 2015 third India-Africa Forum-Summit which happened to be much larger event than two previous forum summits in 2008 and 2011. However energetic policy of N. Modi has not brought India-Africa relations to a new level yet. While planned visit of N. Modi to a number of African countries in July 2016 is seen as a step to achieve this goal, his meetings with representatives of Indian communities in these African countries could be regarded as a sign of a new approach to the Indian Diaspora as “Ambassadors of India”. That could bring some controversy as many South African Indians consider themselves only citizens of their country and no more. Besides, the Indian government should take all necessary measures to prevent racist attacks against Africans in India which greatly tarnish the Indian image in the eyes of Africans.

  10. Current Information Gaps in Micronutrient Research, Programs and Policy: How Can We Fill Them?

    Science.gov (United States)

    Allen, Lindsay H

    2016-01-01

    Micronutrient (MN) interventions have a very positive effect on public health and have been a major focus of nutrition research and policy for over 3 decades. Most MN policies are established by the World Health Organization based on available evidence from well-designed trials. These include recommendations on iron + folic acid supplements for pregnancy, high-dose vitamin A supplementation for children folic acid fortification can be harmful in population groups with a high prevalence of vitamin B12 deficiency. The most effective dose of MNs has rarely been tested systematically. MN interventions alone are not very effective for improving the growth and development of young children. Newer methods for the analysis of MNs in breast milk are revealing low concentrations in many populations, so more information is needed on the effects of different interventions on milk nutrient content. We need to improve biomarkers of MN status and should measure multiple biological responses to MN interventions using modern nutritional science methods, including metabolomics, proteomics and epigenetics; these will reveal effects of MNs that are not yet fully appreciated.

  11. Medication management policy, practice and research in Australian residential aged care: Current and future directions.

    Science.gov (United States)

    Sluggett, Janet K; Ilomäki, Jenni; Seaman, Karla L; Corlis, Megan; Bell, J Simon

    2017-02-01

    Eight percent of Australians aged 65 years and over receive residential aged care each year. Residents are increasingly older, frailer and have complex care needs on entry to residential aged care. Up to 63% of Australian residents of aged care facilities take nine or more medications regularly. Together, these factors place residents at high risk of adverse drug events. This paper reviews medication-related policies, practices and research in Australian residential aged care. Complex processes underpin prescribing, supply and administration of medications in aged care facilities. A broad range of policies and resources are available to assist health professionals, aged care facilities and residents to optimise medication management. These include national guiding principles, a standardised national medication chart, clinical medication reviews and facility accreditation standards. Recent Australian interventions have improved medication use in residential aged care facilities. Generating evidence for prescribing and deprescribing that is specific to residential aged care, health workforce reform, medication-related quality indicators and inter-professional education in aged care are important steps toward optimising medication use in this setting.

  12. Management for Mountain Pine Beetle Outbreak Suppression: Does Relevant Science Support Current Policy?

    Directory of Open Access Journals (Sweden)

    Diana L. Six

    2014-01-01

    Full Text Available While the use of timber harvests is generally accepted as an effective approach to controlling bark beetles during outbreaks, in reality there has been a dearth of monitoring to assess outcomes, and failures are often not reported. Additionally, few studies have focused on how these treatments affect forest structure and function over the long term, or our forests’ ability to adapt to climate change. Despite this, there is a widespread belief in the policy arena that timber harvesting is an effective and necessary tool to address beetle infestations. That belief has led to numerous proposals for, and enactment of, significant changes in federal environmental laws to encourage more timber harvests for beetle control. In this review, we use mountain pine beetle as an exemplar to critically evaluate the state of science behind the use of timber harvest treatments for bark beetle suppression during outbreaks. It is our hope that this review will stimulate research to fill important gaps and to help guide the development of policy and management firmly based in science, and thus, more likely to aid in forest conservation, reduce financial waste, and bolster public trust in public agency decision-making and practice.

  13. Applying Earlier Literacy Research in Iran to Current Literacy Theory and Policy

    Directory of Open Access Journals (Sweden)

    Brian Street

    2013-05-01

    Full Text Available In this paper, I attempt to bring together approaches toliteracy in theory and in practice, drawing upon variousactivities I have been involved in over the years–research inIranian villages during the 1970s; linking research andtheory to literacy policy, with particular reference to acontribution to the Unesco Global Monitoring Report in2004 and involvement in an ongoing adult literacy trainingprogramme appropriately entitled Learning Empowermentthrough Training in Ethnographic Research (LETTER.IJSCL is interested in publishing original research andreview articles on the relationship between society, culture,and language and in particular ‘linking sound theoreticalapproaches on these fields with visible practical applicationsthat can be used by specialists in anthropology, sociology,linguistics, education, intercultural studies, and policymaking’. I hope that this piece on literacy, with duereference to work in Iran, will fit with that brief.

  14. Current account imbalances in the EMU: An assessment of official policy responses

    Directory of Open Access Journals (Sweden)

    Dodig Nina

    2015-01-01

    Full Text Available To handle the sovereign debt crisis in general and macroeconomic imbalances in particular the leading EU institutions and the Troika (European Central Bank, European Commission and International Monetary Fund adopted two broad approaches: The short-term approach is based on enhancing the Stability and Growth Pact and to impose fiscal austerity on crisis countries. The medium- to long-term strategy consists of internal devaluation via reducing wage costs. Both approaches were combined with structural adjustment programs in the spirit of the Washington Consensus. The Troika’s policy implies an asymmetric adjustment process burdening only crisis countries. It led to the shrinking of demand and output in crisis countries comparable to the Great Depression and brought the European Monetary Union to the edge of deflation. These polices must be judged as mislead increasing the risk of Japanese disease with more than one lost decade.

  15. What the Hell Do We Do Now? A Policy Options Analysis of State, Local, and Tribal Law Enforcement Participation in Immigration Enforcement

    Science.gov (United States)

    2013-09-01

    sanctuary policy to provide a basis to “establish trust by building relationships.”187 And in Oregon, a state with a sanctuary policy, the Portland ...be highly adaptable if employed correctly Focuses on existing/standard practice. Immigration investigation/enfor cement only employed post...Medium Sized Police Agencies During a Recession.” 89 demonstrate POP techniques and strategies to trainees as they work together on actual projects

  16. Chronic non-communicable diseases in Cameroon - burden, determinants and current policies

    Directory of Open Access Journals (Sweden)

    Echouffo-Tcheugui Justin B

    2011-11-01

    Full Text Available Abstract Cameroon is experiencing an increase in the burden of chronic non-communicable diseases (NCDs, which accounted for 43% of all deaths in 2002. This article reviews the published literature to critically evaluate the evidence on the frequency, determinants and consequences of NCDs in Cameroon, and to identify research, intervention and policy gaps. The rising trends in NCDs have been documented for hypertension and diabetes, with a 2-5 and a 10-fold increase in their respective prevalence between 1994 and 2003. Magnitudes are much higher in urban settings, where increasing prevalence of overweight/obesity (by 54-82% was observed over the same period. These changes largely result from the adoption of unfavorable eating habits, physical inactivity, and a probable increasing tobacco use. These behavioral changes are driven by the economic development and social mobility, which are part of the epidemiologic transition. There is still a dearth of information on chronic respiratory diseases and cancers, as well as on all NDCs and related risk factors in children and adolescents. More nationally representative data is needed to tract risk factors and consequences of NCDs. These conditions are increasingly been recognized as a priority, mainly through locally generated evidence. Thus, national-level prevention and control programs for chronic diseases (mainly diabetes and hypertension have been established. However, the monitoring and evaluation of these programs is necessary. Budgetary allocations data by the ministry of health would be helpful, to evaluate the investment in NCDs prevention and control. Establishing more effective national-level tobacco control measures and food policies, as well as campaigns to promote healthy diets, physical activity and tobacco cessation would probably contribute to reducing the burden of NCDs.

  17. Did Brisbane Grow Smartly? Drivers of City Growth 1991-2001 and Lessons for Current Policies

    Directory of Open Access Journals (Sweden)

    Farjana Mostafiz Shatu

    2014-10-01

    Full Text Available Urban areas are growing unsustainably around the world; however, the growth patterns and their associated drivers vary between contexts. As a result, research has highlighted the need to adopt case study based approaches to stimulate the development of new theoretic understandings. Using land-cover data sets derived from Landsat images (30 m × 30 m, this research identifies both patterns and drivers of urban growth in a period (1991-2001 when a number of policy acts were enacted aimed at fostering smart growth in Brisbane, Australia. A linear multiple regression model was estimated using the proportion of lands that were converted from non-built-up (1991 to built-up usage (2001 within a suburb as a dependent variable to identify significant drivers of land-cover changes. In addition, the hot spot analysis was conducted to identify spatial biases of land-cover changes, if any. Results show that the built-up areas increased by 1.34% every year. About 19.56% of the non-built-up lands in 1991 were converted into built-up lands in 2001. This conversion pattern was significantly biased in the northernmost and southernmost suburbs in the city. This is due to the fact that, as evident from the regression analysis, these suburbs experienced a higher rate of population growth, and had the availability of habitable green field sites in relatively flat lands. The above findings suggest that the policy interventions undertaken between the periods were not as effective in promoting sustainable changes in the environment as they were aimed for.

  18. The Current Situation of ICT Development in the Middle East and ICT Support Policies. The Case of Syrian Arab Republic.

    Directory of Open Access Journals (Sweden)

    Tatsuya Yamamoto

    2004-04-01

    Full Text Available The purpose of this paper is to examine how ICT development is progressing and what kind of political and social effects have been occurring (or could occur in the near future in Middle Eastern Arabic countries. To examine this theme, this paper will adopt the Syrian Arab Republic as a case. To understand the Syrian government's policy toward the ICT development, it is necessary to examine the domestic political situation, since they are closely related. Under the Bashar Al- Asad's regime, we can confirm several reasons why they have to move forward on their ICT development policy and why it has become a crucial issue, which they cannot evade, as they had done under the previous regime, Hafez Al- Asad's regime. The situation that the Syrian government is facing right now is known by the term, "Dictator's Dilemma". This paper tries to provide bases in order to examine and explore this dilemma in Syria. Also, when we examine ICT development in Syria, it is important to consider the ICT support policies, which are mainly conducted by OECD countries and international organizations and stem from the issue of "Digital Divide". This is why international assistances could have great effect on ICT development in Syria. As a provisional conclusion of this paper, I will summarize how we can understand the current situation of ICT development in Syria, and I will also comment on the future prospect of the dilemma that the Syrian government is facing at the present time.

  19. Tax Policy Options for Achieving Inclusive Growth%实现包容性增长的税收政策选择

    Institute of Scientific and Technical Information of China (English)

    廖家勤; 宁扬

    2014-01-01

    The inclusive growth that is consistent with the requirements of the scientific development view is one harmonious and co-existed mode .The orientation of tax function based on inclusive growth are :(1) fully motivate the enthusiasm of all kinds of economic subject ,create more economic opportunities as far as possible;(2 ) eliminate the tax barriers for common people participating in the economic process and sharing the achievements of economic ;(3) improve people-oriented ,harmonious and co-existed quality of tax grow th .Due to the unreasonable tax structure ,the preferential tax policy bias ,inappropriate business tax environment ,our current tax system hinders the implementation of inclusive growth .The basic path of promoting the innovation in the tax system for inclusive grow thare :(1) sharply reduce the general flow of goods and services tax rate ,reduce the proportion of indirect tax ,improve the proportion of direct tax ,to optimize the tax structure ;(2 ) effectively motivate ordinary public entrepreneurship and employment , promote the development of county economy as the guidance ,optimize the design of the tax preferential policies ;(3) build a service-oriented government ,create an environment w hich is suitable for business .%包容性增长是与科学发展观要求相一致的和谐共生的经济增长方式。基于包容性增长的税收功能定位是:充分激励各类经济主体的积极性,尽可能创造更多的经济机会;消除普通民众参与经济增长过程及分享经济成果的税收障碍;提升以人为本和谐共生的税收增长质量。我国现行税制由于税制结构不合理、税收优惠政策偏颇、营商税务环境不适宜,阻碍了包容性增长的实现。推进税收制度创新实现包容性增长的基本路径是:大幅降低一般商品和服务的流转税率,降低间接税比重、提升直接税比重,以优化税制结构;以有效激励普通民众创业和就业及促

  20. Assessing land degradation and acknowledging adaptive policy options to face with changes: an integrated approach applied to a semiarid agropastoral system

    Science.gov (United States)

    Tarrasón, D.; Ravera, F.; Reed, M.; Dougill, A.

    2009-04-01

    The complexity of assessing land degradation on semiarid systems deals with challenges that have rarely been addressed. Land degradation is a human-induced and permanent reduction of key ecosystem functions and services at different temporal and spatial scale. Initial attempts to assess land degradation at a broader scale were based on expert opinion, however the empirical bases to sustain these estimations are weak and the ecological data are still scarce. In addition, such approaches are essentially subjective and they reflect the objectives and assumptions of those making the assessment, who are rarely land users themselves. Currently, the concept of "land degradation" is debated, and in the last years have emerged a growing number of efforts to develop land degradation participatory assessment methods that could capture a more complex understanding of human-environment interactions. This study proposes an interdisciplinary and hybrid methodology, combining local and scientific knowledge, to assess land degradation in mixed farming systems. Specifically, i) it describes and analyses the mixed farming system and it explores how historically political, social and institutional local factors have interacted with ecological process, ii) it identifies key ecosystem processes and services needed to support the agropastoral systems that are perceived to be under threat from land degradation; iii) it assesses the status and trends of these key ecosystem services; and iv) it identifies and evaluates potential management alternatives to prevent land degradation and cope with changes (e.g. climate change). We show how to achieve, through a co-construction of hybrid knowledge between scientific and farmers, a more accurate and reliable appraisal of land degradation, since farmer's perception is contextualized, dynamic and complex and involves simultaneously multiple temporal and spatial scales and multiple dimensions of analysis that could help the scientific exploration

  1. Politika «Severnogo izmerenija»: sovremennoe sostojanie i perspektivy razvitija [The Northern Dimension policy: current state and development prospects

    Directory of Open Access Journals (Sweden)

    Bolotnikova Yekaterina

    2010-01-01

    Full Text Available This article examines the evolution and current state of the Northern Dimension policy and its role in Russia-EU relations. The authors analyse the discrepancy between the actual achievements of the Northern Dimension and its potential and the over-high expectations, which accompanied the policy renewal.

  2. Analysis of operations and cyber security policies for a system of cooperating Flexible Alternating Current Transmission System (FACTS) devices.

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, Laurence R.; Tejani, Bankim; Margulies, Jonathan; Hills, Jason L.; Richardson, Bryan T.; Baca, Micheal J.; Weiland, Laura

    2005-12-01

    Flexible Alternating Current Transmission Systems (FACTS) devices are installed on electric power transmission lines to stabilize and regulate power flow. Power lines protected by FACTS devices can increase power flow and better respond to contingencies. The University of Missouri Rolla (UMR) is currently working on a multi-year project to examine the potential use of multiple FACTS devices distributed over a large power system region in a cooperative arrangement in which the FACTS devices work together to optimize and stabilize the regional power system. The report describes operational and security challenges that need to be addressed to employ FACTS devices in this way and recommends references, processes, technologies, and policies to address these challenges.

  3. Trade reform, policy uncertainty, and the current account: a non expected-utility approach

    NARCIS (Netherlands)

    van Wijnbergen, S.J.G.

    1992-01-01

    Rapid and comprehensive reduction in barriers to international trade has often been followed by a sharp deterioration in the current account. The macroeconomic counterpart of the deterioration has typically been a decline in private savings; no clear response pattern has been observed for private in

  4. [Recruiting and Personal Development in Surgical Departments of Large Referral Centers - Current Practice and Options for Improvement from Industry and Service Business].

    Science.gov (United States)

    Homayounfar, K; König, S; Rabe, C; Beck-Broichsitter, B; Lützen, U; Ghadimi, M B; Schmidt, C

    2016-06-23

    Background: Cut-throat competition, cost pressure, generation Y, shortage of qualified staff and feminisation influence human resources management in visceral surgery. The assessment of the current situation by chief surgeons (CS) as well as proof of transferability of strategies from industry and service business (ISB) have not yet been investigated. Material and Methods: The CS of university hospitals and large referral centres (> 800 beds) were interviewed (n = 100) on the basis of a standardised questionnaire including 43 items. Closed questions were designed with a 5-point Likert scale and their analysis was presented as means (MW) and standard deviations (±). Ten human resources manager (HMR) of ISB were invited to participate in 45-minute telephone interviews. Results: Thirty-seven CS participated in the survey, 15 of whom were full professors. Unsolicited applications (100 %), job advertisements (78 %) and direct approaches to final year students (78 %) were the most common ways of recruitment. Only 17 % of CS used a standardised form for preparation. Professional expertise (MW 2.2 ± 0.9), social skills (MW 1.9 ± 0.6) and excellent German language skills (MW 1.8 ± 0.8) were named as important qualifications for employment, while references and certificates were regarded as being less important (MW 3.2 ± 0.9). Personal development was regarded as important (MW 1.1 ± 0.2), but a defined period for residency was not guaranteed (MW 3.0 ± 1.5). Transparent selection criteria for career opportunities (MW 2.5 ± 1.1) and different career models (MW 2.7 ± 1.2) were only rarely available. Six HRM participated in the interviews. Active head-hunting (75 %), Internet platforms (75 %), presentations at conferences (75 %), as well as hiring trainees (50 %), job advertisements (50 %) and social media (50 %) were established options to find qualified employees. Professional and management careers were often

  5. Control and management of congenital Chagas disease in Europe and other non-endemic countries: current policies and practices.

    Science.gov (United States)

    Soriano-Arandes, Antoni; Angheben, Andrea; Serre-Delcor, Nuria; Treviño-Maruri, Begoña; Gómez I Prat, Jordi; Jackson, Yves

    2016-05-01

    Identifying pregnant women infected with Trypanosoma cruzi is one of the major challenges for preventing and controlling Chagas disease (CD) in non-endemic countries. The aim of this paper was to perform a policy evaluation of the current practices of congenital Chagas disease (CCD) control in non-endemic countries and to propose specific targets for enhanced interventions to tackle this emerging health problem outside the endemic areas of Latin America. We conducted a mixed method review of CCD policy strategies by searching the literature in the PubMed, Google Scholar and the World Health Organization (WHO) databases using the key terms 'CCD', 'paediatric Chagas disease' and 'non-endemic countries'; as free text and combined as one phrase to increase the search sensitivity. Reviews, recommendations, guidelines and control/surveillance programme reports were included. Of 427 CCD papers identified in non-endemic countries, 44 matched the inclusion. Although local programmes were launched in different countries with large numbers of Latin American immigrants, there were considerable disparities in terms of the programmes' distribution, delivery, integration and appropriated CCD control strategies. Moreover, Catalonia, Spain is the only region/country with an established systematic monitoring of CCD in pregnant women from Latin American countries. Given the worldwide dissemination of CD, the nature of its vertical transmission, and the gaps of the current strategies in non-endemic countries, there is an urgent need to standardise, expand and reinforce the control measures against CCD transmission. © 2016 John Wiley & Sons Ltd.

  6. Solar energy policy review

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-08-17

    A number of memoranda and reports are collected which deal with evaluations of solar energy policy options, including direct and indirect labor impacts and costs of different options and consumer protection. (LEW)

  7. Upgradation and modernization of eye banking services: Integrating tradition with innovative policies and current best practices.

    Science.gov (United States)

    Tandon, Radhika; Singh, Archita; Gupta, Noopur; Vanathi, M; Gupta, Vivek

    2017-02-01

    The purpose of this study is to review the history and evolution of the National Eye Bank (NEB) and analyze the impact over the years and report the outcome of the invested resources. Review of archival material, records, project reports, policy and procedures' manuals, and publications was done. Descriptive and analytical processing of data obtained was undertaken. Parameters evaluated included total collection, transplantation, utilization rates of donor cornea, changing trends over time in terms of numbers and duration of recipients waiting, impactful research translated into changes in standard operating protocols, new facilities, and subsequent effects on numbers or quality assurance measures and overview of major achievements. Periodic situational analysis with contextual relevance and interpretation of outcomes was done pertaining to national goals and international standards. The NEB and cornea services have played a key leadership role in furthering the development of eye banking and corneal transplantation services. The contribution extends beyond routine patient care to education, training, generation of resources, advocacy, and policymaking. In quantifiable terms, the overall performance has steadily increased over the years. Major contributions include training of doctors, eye bank staff and corneal surgeons, introduction of innovative techniques for corneal transplantation, setting of national standards for eye banking and provision of preservation media, customized corneal, and ocular surface cell replacement therapy in collaboration with other departments and institutes. The eye banking and corneal transplantation facilities have evolved with time providing quality services, modernized as appropriate with updated knowledge and incorporating technological advances supported by the systematic evidence-based approach.

  8. Upgradation and modernization of eye banking services: Integrating tradition with innovative policies and current best practices

    Science.gov (United States)

    Tandon, Radhika; Singh, Archita; Gupta, Noopur; Vanathi, M; Gupta, Vivek

    2017-01-01

    Purpose: The purpose of this study is to review the history and evolution of the National Eye Bank (NEB) and analyze the impact over the years and report the outcome of the invested resources. Methods: Review of archival material, records, project reports, policy and procedures' manuals, and publications was done. Descriptive and analytical processing of data obtained was undertaken. Parameters evaluated included total collection, transplantation, utilization rates of donor cornea, changing trends over time in terms of numbers and duration of recipients waiting, impactful research translated into changes in standard operating protocols, new facilities, and subsequent effects on numbers or quality assurance measures and overview of major achievements. Periodic situational analysis with contextual relevance and interpretation of outcomes was done pertaining to national goals and international standards. Results: The NEB and cornea services have played a key leadership role in furthering the development of eye banking and corneal transplantation services. The contribution extends beyond routine patient care to education, training, generation of resources, advocacy, and policymaking. In quantifiable terms, the overall performance has steadily increased over the years. Major contributions include training of doctors, eye bank staff and corneal surgeons, introduction of innovative techniques for corneal transplantation, setting of national standards for eye banking and provision of preservation media, customized corneal, and ocular surface cell replacement therapy in collaboration with other departments and institutes. Conclusion: The eye banking and corneal transplantation facilities have evolved with time providing quality services, modernized as appropriate with updated knowledge and incorporating technological advances supported by the systematic evidence-based approach. PMID:28345565

  9. Illiquidity Premia in the Equity Options Market

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Goyenko, Ruslan; Jacobs, Kris

    Illiquidity is well-known to be a significant determinant of stock and bond returns. We report on illiquidity premia in the equity options market. An increase in option illiquidity decreases the current option price and implies higher expected option returns. This effect is statistically and econ...

  10. Current systematic carbon-cycle observations and the need for implementing a policy-relevant carbon observing system

    Science.gov (United States)

    Ciais, P.; Dolman, A. J.; Bombelli, A.; Duren, R.; Peregon, A.; Rayner, P. J.; Miller, C.; Gobron, N.; Kinderman, G.; Marland, G.; Gruber, N.; Chevallier, F.; Andres, R. J.; Balsamo, G.; Bopp, L.; Bréon, F.-M.; Broquet, G.; Dargaville, R.; Battin, T. J.; Borges, A.; Bovensmann, H.; Buchwitz, M.; Butler, J.; Canadell, J. G.; Cook, R. B.; DeFries, R.; Engelen, R.; Gurney, K. R.; Heinze, C.; Heimann, M.; Held, A.; Henry, M.; Law, B.; Luyssaert, S.; Miller, J.; Moriyama, T.; Moulin, C.; Myneni, R. B.; Nussli, C.; Obersteiner, M.; Ojima, D.; Pan, Y.; Paris, J.-D.; Piao, S. L.; Poulter, B.; Plummer, S.; Quegan, S.; Raymond, P.; Reichstein, M.; Rivier, L.; Sabine, C.; Schimel, D.; Tarasova, O.; Valentini, R.; Wang, R.; van der Werf, G.; Wickland, D.; Williams, M.; Zehner, C.

    2014-07-01

    A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify the effectiveness of policies aiming to reduce greenhouse gas emissions and increase carbon sequestration. Building an integrated carbon observation system requires transformational advances from the existing sparse, exploratory framework towards a dense, robust, and sustained system in all components: anthropogenic emissions, the atmosphere, the ocean, and the terrestrial biosphere. The paper is addressed to scientists, policymakers, and funding agencies who need to have a global picture of the current state of the (diverse) carbon observations. We identify the current state of carbon observations, and the needs and notional requirements for a global integrated carbon observation system that can be built in the next decade. A key conclusion is the substantial expansion of the ground-based observation networks required to reach the high spatial resolution for CO2 and CH4 fluxes, and for carbon stocks for addressing policy-relevant objectives, and attributing flux changes to underlying processes in each region. In order to establish flux and stock diagnostics over areas such as the southern oceans, tropical forests, and the Arctic, in situ observations will have to be complemented with remote-sensing measurements. Remote sensing offers the advantage of dense spatial coverage and frequent revisit. A key challenge is to bring remote-sensing measurements to a level of long-term consistency and accuracy so that they can be efficiently combined in models to reduce uncertainties, in synergy with ground-based data. Bringing tight observational constraints on fossil fuel and land use change emissions will be the biggest challenge for deployment of a policy-relevant integrated carbon observation system. This will require in situ and remotely sensed data at much higher

  11. An Exploratory Study of the Factors That Influence Enrolling in Alternative Educational Options: Adult Perceptions and Implications for Policy and Practice

    Science.gov (United States)

    Kocsis-McNerney, Violet

    2013-01-01

    This research obtained information using focus groups as qualitative method to determine the factors that influenced alternative education decisions. The purpose of this study was to help bridge theory, research, and educational practices and examine policy reform efforts. Through the lenses of returning adult education students, this research…

  12. Risk factors for secondary transmission of Shigella infection within households: implications for current prevention policy

    Directory of Open Access Journals (Sweden)

    Boveé Lian

    2012-12-01

    Full Text Available Abstract Background Internationally, guidelines to prevent secondary transmission of Shigella infection vary widely. Cases, their contacts with diarrhoea, and those in certain occupational groups are frequently excluded from work, school, or daycare. In the Netherlands, all contacts attending pre-school (age 0–3 and junior classes in primary school (age 4–5, irrespective of symptoms, are also excluded pending microbiological clearance. We identified risk factors for secondary Shigella infection (SSI within households and evaluated infection control policy in this regard. Methods This retrospective cohort study of households where a laboratory confirmed Shigella case was reported in Amsterdam (2002–2009 included all households at high risk for SSI (i.e. any household member under 16 years. Cases were classified as primary, co-primary or SSIs. Using univariable and multivariable binomial regression with clustered robust standard errors to account for household clustering, we examined case and contact factors (Shigella serotype, ethnicity, age, sex, household size, symptoms associated with SSI in contacts within households. Results SSI occurred in 25/ 337 contacts (7.4%: 20% were asymptomatic, 68% were female, and median age was 14 years (IQR: 4–38. In a multivariable model adjusted for case and household factors, only diarrhoea in contacts was associated with SSI (IRR 8.0, 95% CI:2.7-23.8. In a second model, factors predictive of SSI in contacts were the age of case (0–3 years (IRRcase≥6 years:2.5, 95% CI:1.1-5.5 and 4–5 years (IRRcase≥6 years:2.2, 95% CI:1.1-4.3 and household size (>6 persons (IRR2-4 persons 3.4, 95% CI:1.2-9.5. Conclusions To identify symptomatic and asymptomatic SSI, faecal screening should be targeted at all household contacts of preschool cases (0–3 years and cases attending junior class in primary school (4–5 years and any household contact with diarrhoea. If screening was limited to these groups, only

  13. Are ethical norms and current policies still relevant in face of the recent mass terror events?

    Science.gov (United States)

    Simon, Tomer; Goldberg, Avishay; Adini, Bruria

    2016-10-04

    The widespread utilization of social media in recent terror attacks in major European cities should raise a "red flag" for the emergency medical response teams. The question arises as to the impact of social media during terror events on the healthcare system. Information was published well before any emergency authority received a distress call or was requested to respond. Photos published at early stages of the attacks, through social media were uncensored, presenting identifiable pictures of victims. Technological advancements of recent years decrease and remove barriers that enable the public to use them as they see fit. These attacks raise ethical considerations for the patients and their rights as they were outsourced from the medical community, into the hands of the public. The healthcare system should leverage social media and its advantages in designing response to terror, but this requires a re-evaluation and introspection into the current emergency response models.

  14. Thermal test options

    Energy Technology Data Exchange (ETDEWEB)

    Koski, J.A.; Keltner, N.R.; Sobolik, K.B.

    1993-02-01

    Shipping containers for radioactive materials must be qualified to meet a thermal accident environment specified in regulations, such at Title 10, Code of Federal Regulations, Part 71. Aimed primarily at the shipping container design, this report discusses the thermal testing options available for meeting the regulatory requirements, and states the advantages and disadvantages of each approach. The principal options considered are testing with radiant heat, furnaces, and open pool fires. The report also identifies some of the facilities available and current contacts. Finally, the report makes some recommendations on the appropriate use of these different testing methods.

  15. Policy options for pharmaceutical pricing and purchasing:Issues for low-and middle-income countries%中低收入国家药品定价和采购的政策选择

    Institute of Scientific and Technical Information of China (English)

    TuanAnh Nguyen; Rosemary Knight; Elizabeth Ellen Roughead; Geoffrey Brooks; Andrea Mant

    2015-01-01

    Pharmaceutical expenditure is rising globally. Most high-income countries have exercised pricing or purchasing strategies to address this pressure. Low- and middle-income countries ( LMICs) , however, usually have less regulated pharmaceutical markets and often lack feasible pricing or purchasing strategies, notwithstanding their wish to effectively manage medicine budgets. In high-income countries, most medicines payments are made by the state or health insurance institutions. In LMICs, most pharmaceutical expenditure is out-ofpocket which creates a dif-ferent dynamic for policy enforcement. The paucity of rigorous studies on the effectiveness of pharmaceutical pricing and purchasing strategies makes it especially difficult for policy makers in LMICs to decide on a course of action. This article reviews published articles on pharmaceutical pricing and purchasing policies. Many policy options for medicine pricing and purchasing have been found to work but they also have attendant risks. No one option is decisively pre-ferred;rather a mix of options may be required based on country-specific context. Empirical studies in LMICs are lacking. However, risks from any one policy option can reasonably be argued to be greater in LMICs which often lack strong legal systems, purchasing and state institutions to underpin the healthcare system. Key factors are identified to assist LMICs improve their medicine pricing and purchasing systems.%药品支出上涨是全球问题。为应对这一压力,多数高收入国家制定并实施了一系列的药品定价和采购政策。然而,尽管中低收入国家希望能够有效控制药品支出预算,但其药品市场不规范,并缺乏可行的药品定价或采购政策。高收入国家药品支出通常由国家或社会医疗保险机构支付,而中低收入国家大多是个人自付,这会给政策执行造成阻力。由于对药品定价和采购政策是否高效缺乏严谨的调查研究,因而一定

  16. Considerations on the current universal vaccination policy against hepatitis A in Greece after recent outbreaks.

    Directory of Open Access Journals (Sweden)

    Kassiani Mellou

    Full Text Available Greece is the only European Union member state that in 2008 included hepatitis A (HAV vaccine in the routine national childhood immunization program (NCIP. Given that the resources allocated to public health have dramatically decreased since 2008 and that Greece is a low endemicity country for the disease, the benefit from universal vaccination has been questioned. The aim of this paper is to summarize the available epidemiological data of the disease for 1982-2013, and discuss the effects of universal vaccination on disease morbidity. Descriptive analysis, ARIMA modeling and time series intervention analysis were conducted using surveillance data of acute HAV. A decreasing trend of HAV notification rate over the years was identified (p<0.001. However, universal vaccination (~ 80% vaccine coverage of children had no significant effect on the annual number of reported cases (p = 0.261 and has resulted to a progressive increase of the average age of infection in the general population. The mean age of cases before the inclusion of the vaccine to NCIP (24.1 years, SD = 1.5 was significantly lower than the mean age of cases after 2008 (31.7 years, SD = 2.1 (p<0.001. In the last decade, one third of all reported cases were Roma (a population accounting for 1.5% of the country's total population and in 2013 three outbreaks with 16, 9 and 25 Roma cases respectively, were recorded, indicating the decreased effectiveness of the current immunization strategy in this group. Data suggest that universal vaccination may need to be re-considered. Probably a more cost effective approach would be to implement a program that will include: a vaccination of high risk groups, b universal vaccination of Roma children and improving conditions at Roma camps, c education of the population and travel advice, and d enhancement of the control measures to increase safety of shellfish and other foods.

  17. Energy policy in a changing social order

    Energy Technology Data Exchange (ETDEWEB)

    Schaller, D.A.

    1981-01-01

    In this paper, the background of energy management and use relative to public policymaking is reviewed. Many of the more-prominent social cross currents, such as: consumerism, resistance to nuclear power, tax rebellion, etc., are identified and described. Conventional and alternate energy policy options are analyzed. 41 refs.

  18. ATR Spent Fuel Options Study

    Energy Technology Data Exchange (ETDEWEB)

    Connolly, Michael James [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bean, Thomas E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Brower, Jeffrey O. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Luke, Dale E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Patterson, M. W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Robb, Alan K. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sindelar, Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, Rebecca E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tonc, Vincent F. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tripp, Julia L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    The Advanced Test Reactor (ATR) is a materials and fuels test nuclear reactor that performs irradiation services for the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Naval Reactors, the National Nuclear Security Administration (NNSA), and other research programs. ATR achieved initial criticality in 1967 and is expected to operate in support of needed missions until the year 2050 or beyond. It is anticipated that ATR will generate approximately 105 spent nuclear fuel (SNF) elements per year through the year 2050. Idaho National Laboratory (INL) currently stores 2,008 ATR SNF elements in dry storage, 976 in wet storage, and expects to have 1,000 elements in wet storage before January 2017. A capability gap exists at INL for long-term (greater than the year 2050) management, in compliance with the Idaho Settlement Agreement (ISA), of ATR SNF until a monitored retrievable geological repository is open. INL has significant wet and dry storage capabilities that are owned by the DOE Office of Environmental Management (EM) and operated and managed by Fluor Idaho, which include the Idaho Nuclear Technology and Engineering Center’s (INTEC’s) CPP-666, CPP-749, and CPP-603. In addition, INL has other capabilities owned by DOE-NE and operated and managed by Battelle Energy Alliance, LLC (BEA), which are located at the Materials and Fuel Complex (MFC). Additional storage capabilities are located on the INL Site at the Naval Reactors Facility (NRF). Current INL SNF management planning, as defined in the Fluor Idaho contract, shows INTEC dry fuel storage, which is currently used for ATR SNF, will be nearly full after transfer of an additional 1,000 ATR SNF from wet storage. DOE-NE tasked BEA with identifying and analyzing options that have the potential to fulfill this capability gap. BEA assembled a team comprised of SNF management experts from Fluor Idaho, Savannah River Site (SRS), INL/BEA, and the MITRE Corp with an objective of developing and analyzing

  19. Unification Strategy for North and South Korea: The Most Prudent U.S. Policy Option to Solve the North Korean Nuclear Crisis

    Science.gov (United States)

    2004-09-01

    wonderful wife, Judy; my two precious daughters, Hana and Kara; and my parents , Kwang-hi and Kun-ye for their enduring love and support. x...North or South Koreans, have a deep sense of pride that comes from thousands of years of Confucian heritage. As the Shufeldt mission of 1882 has...it is difficult, if not impossible, to see these policies as ethically or morally principled. Korea was used by the U.S. as a means to an end

  20. A NOTE ON THE VALUATION OF AMERICAN OPTION

    Institute of Scientific and Technical Information of China (English)

    边保军; 姜礼尚

    2003-01-01

    American options give holder a right to exercise it at any time at will,the holder should to make the exercise policy in such a way that the expected payoff from the option will be maximized. In this note we prove that it is equivalent to a fact which makes the option value and option delta continuous.

  1. Current health care system policy for vulnerability reduction in the United States of America: a personal perspective.

    Science.gov (United States)

    Eckenfels, Edward J

    2002-04-01

    To raise questions about how the United States of America, which spends 1.3 trillion dollars on health care, conducts cutting-edge biomedical research, has the most advanced medical technology, and trains a cadre of highly competent health professionals cares for the most vulnerable members of its population. Relevant statistical data were extrapolated from the most current statistical sources and research reports, and assessed in terms of existing practices and policies. The data clearly demonstrated that particular population cohorts -- the elderly, the poor, new immigrants, the homeless, the HIV-positive, and substance abusers -- were especially vulnerable to illness and its consequences. Since American medicine, despite all of its science, technology, and clinical competence, operates in a non-system, there is currently no efficacious approach to vulnerability reduction. To turn health care in the U.S. into a high quality, comprehensive, and cost-effective system, government officials, health care planners, and medical practitioners must address a series of fundamental social, economic, and political issues. What other countries, like those in South Eastern Europe, can learn from this is not to duplicate these mistakes.

  2. 21 CFR 1404.135 - May the Office of National Drug Control Policy exclude a person who is not currently...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false May the Office of National Drug Control Policy....135 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1404.135 May the Office of National Drug Control Policy exclude a person who is...

  3. Environmental agricultural policy in Japan in harmony with WTO agricultural agreements: current situation and its development (Ⅱ)

    Institute of Scientific and Technical Information of China (English)

    Masaaki ISHIDA

    2005-01-01

    Environmental agricultural policies in Japan have yet to be initiated in earnest, being in what might be called a “preparation stage.” The reasons for this have already been discussed above, but in fact it is not only the environmental agricultural policies that are incomplete; so too are the environmental measures that would form the foundations for these policies.

  4. Current management options for displaced intra-articular calcaneal fractures: Non-operative, ORIF, minimally invasive reduction and fixation or primary ORIF and subtalar arthrodesis. A contemporary review.

    Science.gov (United States)

    Sharr, P J; Mangupli, M M; Winson, I G; Buckley, R E

    2016-03-01

    Management of Displaced Intra-articular Calcaneal Fractures (DIACFs) continues to be technically demanding. The literature has not been definitive in its guidance for surgeons dealing with these injuries. Recent publications have further added to the lack of clarity. This review is intended to summarise the present state of knowledge, and provide some genuine guidance for clinicians. To review previous research, focussing on articles published within the last fifteen years, and summarise the findings to aid surgeons in managing DIACFs with choosing best management for patients. We reviewed the best evidence and literature, focussing on articles published within the last fifteen years, and summarised findings into workable recommendations. Variables of (1) patient, (2) the associated soft tissue injury and (3) the fracture characteristics were used to aid surgeons in choosing the best of the available options for each patient that presents with a DIACF. Management of DIACFs can best be divided into four broad categories: (i) non-operative management, (ii) open reduction and internal fixation, (iii) minimally invasive reduction and fixation, and (iv) primary subtalar arthrodesis. The evolution of the literature would suggest orthopaedic surgeons managing calcaneus fractures should have an expert's knowledge, surgical expertise and the latest techniques to cover these four options, to tailor the treatment of DIACFs to the individual patient. Copyright © 2015 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.

  5. Essential Tremor (ET): Surgical Options

    Science.gov (United States)

    ... t respond to propranolol, primidone, or other common ET medications and whose tremor has become debilitating, there ... treatments were first introduced. Current surgical options for ET include Deep Brain Stimulation (DBS) , Focused Ultrasound Thalamotomy , ...

  6. Addressing health care market reform through an insurance exchange: essential policy components, the public plan option, and other issues to consider.

    Science.gov (United States)

    Fronstin, Paul; Ross, Murray N

    2009-06-01

    HEALTH INSURANCE EXCHANGE: This Issue Brief examines issues related to managed competition and the use of a health insurance exchange for the purpose of addressing cost, quality, and access to health care services. It discusses issues that must be addressed when designing an exchange in order to reform the health insurance market and also examines state efforts at health reform that use an exchange. RISK VS. PRICE COMPETITION: The basic component of managed competition is the creation an organized marketplace that brings together health insurers and consumers (either as individuals or through their employers). The sponsor of the exchange would set "rules of engagement" for participating insurers and offer consumers a menu of choices among different plans. Ultimately, the goal of a health insurance exchange is to shift the market from competition based on risk to competition based on price and quality. ADVERSE SELECTION AND AFFORDABILITY: Among the issues that need to be addressed if an exchange that uses managed competition has a realistic chance of reducing costs, improving quality, and expanding coverage: Everyone needs to be in the risk pool, with individuals required to purchase insurance or face significant financial consequences; effective risk adjustment is essential to eliminate risk selection as an insurance business model--forcing competition on costs and quality; the insurance benefit must be specific and clear--without standards governing cost sharing, covered services, and network coverage there is no way to assess whether a requirement to purchase or issue coverage has been met; and subsidies would be necessary for low-income individuals to purchase insurance. THE PUBLIC PLAN OPTION: The public plan option is shaping up to be one of the most contentious issues in the health reform debate. Proponents also believe of a public plan is necessary to drive private insurers toward true competition. Opponents view it as a step toward government-run health

  7. Child Care Subsidy Policies and Practices: Implications for Child Care Providers. New Federalism: Issues and Options for States, Series A. Assessing the New Federalism: An Urban Institute Program To Assess Changing Social Policies.

    Science.gov (United States)

    Adams, Gina; Snyder, Kathleen; Tout, Kathryn

    This brief summarizes the report "Essential but Often Ignored: Child Care Providers in the Subsidy System," examining child care subsidy policies and practices shaping experiences of providers serving subsidized children, particularly those affecting providers' payments and their overall experience with the subsidy system. Research on the voucher…

  8. Deliberating emission reduction options

    Energy Technology Data Exchange (ETDEWEB)

    Dowd, A.M.; Rodriguez, M.; Jeanneret, T. [Commonwealth Scientific and Industrial Research Organisation CSIRO, 37 Graham Rd, Highett VIC 3190 (Australia); De Best-Waldhober, M.; Straver, K.; Mastop, J.; Paukovic, M. [Energy research Centre of the Netherlands ECN, Policy Studies, Amsterdam (Netherlands)

    2012-06-15

    For more than 20 years there has been a concerted international effort toward addressing climate change. International conventions, such as the United Nations Foreign Convention on Climate Change (UNFCCC; ratified in 1994), have been established by committed nations seeking to address global climate change through the reduction of greenhouse gases emitted into the Earth's atmosphere (Global CCS Institute, 2011). Long recognised as the most crucial of the greenhouse gases to impact global warming, the majority of carbon dioxide's anthropogenic global emissions are directly related to fuel combustion of which both Australia and the Netherlands' energy production is significantly reliant. Both these nations will need to consider many opinions and make hard decisions if alternative energy options are to be implemented at the scale that is required to meet international emission targets. The decisions that are required not only need to consider the many options available but also their consequences. Along with politicians, policy developers and industry, the general public also need to be active participants in deciding which energy options, and their subsequent consequences, are acceptable for implementation at the national level. Access to balanced and factual information is essential in establishing informed opinions on the many policy options available. Past research has used several methods to measure public perceptions and opinions yet for complex issues, such as emission reduction, some of these methods have shown to be problematic. For example, semi structured interviews can provide data that is flexible and context rich yet is does also come with the limitations such as it seldom provides a practical assessment that can be utilised from researcher to researcher, across disciplines and public participation techniques. Surveys on the other hand usually address these limitations but surveys that do not encourage comparison of information or ask

  9. A comparative analysis of some policy options to reduce rationing in the UK's NHS: lessons from a general equilibrium model incorporating positive health effects.

    Science.gov (United States)

    Rutten, Martine; Reed, Geoffrey

    2009-01-01

    This paper seeks to determine the macro-economic impacts of changes in health care provision. The resource allocation issues have been explored in theory, by applying the Rybczynski theorem, and empirically, using a computable general equilibrium (CGE) model for the UK with a detailed health component. From the theory, changes in non-health outputs are shown to depend on factor-bias and scale effects, the net effects generally being indeterminate. From the applied model, a rise in the National Health Service (NHS) budget is shown to yield overall welfare gains, which fall by two-thirds assuming health care-specific factors. A nominally equivalent migration policy yields even higher welfare gains.

  10. Implications of theories of asteroid and comet impact for policy options for management of spent nuclear fuel and high-level radioactive wastes

    Science.gov (United States)

    Trask, Newell J.

    1994-01-01

    Concern with the threat posed by terrestrial asteroid and comet impacts has heightened as the catastrophic consequences of such events have become better appreciated. Although the probabilities of such impacts are very small, a reasonable question for debate is whether such phenomena should be taken into account in deciding policy for the management of spent fuel and high-level radioactive waste. The rate at which asteroid or comet impacts would affect areas of surface storage of radioactive waste is about the same as the estimated rate at which volcanic activity would affect the Yucca Mountain area. The Underground Retrievable Storage (URS) concept could satisfactorily reduce the risk from cosmic impact with its associated uncertainties in addition to providing other benefits described by previous authors.

  11. Treatment Options for Narcolepsy

    OpenAIRE

    Barateau, Lucie; Lopez, Régis; Dauvilliers, Yves

    2016-01-01

    International audience; Narcolepsy type 1 and narcolepsy type 2 are central disorders of hypersomnolence. Narcolepsy type 1 is characterized by excessive daytime sleepiness and cataplexy and is associated with hypocretin-1 deficiency. On the other hand, in narcolepsy type 2, cerebrospinal fluid hypocretin-1 levels are normal and cataplexy absent. Despite major advances in our understanding of narcolepsy mechanisms, its current management is only symptomatic. Treatment options may vary from a ...

  12. RELEVANCE OF CITY SIZE AND TRAFFIC CONGESTION AND ITS POLICY OPTIONS%论城市规模与交通拥堵的关联性及其政策意义

    Institute of Scientific and Technical Information of China (English)

    宋博; 赵民

    2011-01-01

    随着城市空间的日益拓展及机动化进程的加快,许多大城市深陷交通拥堵困境.本文首先试图建构模型,探析其拥堵困境的微观机制,进而在公共政策的视角下探讨解决拥堵的各种选择,明确城市交通领域的公共政策逻辑与政府责任.研究发现,若交通结构、城市道路面积占比、城市出行发生的空间分布,以及出行发生密度等既定,则随着城市规模增大,交通拥堵必定会不断加剧.由此可见,城市交通领域的公共政策及公共干预诉求与城市规模有关;制定和实施科学的交通政策、确保城市交通系统的运行效率是大城市、特大城市政府不容回避、刻不容缓的责任.%With the continuous expansion of urban space and acceleration of motorization process, the traffic congestion has been a common problem of numerous mega-cites. The paper tries to construct a model to explore the micro-mechanism of congestion, and investigates choices to solve it from public policy perspective. It study clarifies the logic of public policy and responsibility of the government in urban transportation domain. It finds that, the congestion will worsen with the urban expansion, if the trip mode, road proportion, spatial allocation and density of trip were not structurally improved accordingly. There fore, the improvement of above assumed conditions is probably representing policy options, and the need for public policy and intervention depends on urban size. So formulating and implementing congruent transportation policy to ensure the traffic efficiency is an urgent obligation that mega-cities' government can no longer shunt aside.

  13. Models for evaluation of energy technology and policy options to maximize low carbon source penetration in the United States energy supply.

    Energy Technology Data Exchange (ETDEWEB)

    Pickard, Paul S.; Kataoka, Dawn; Reno, Marissa Devan; Malczynski, Leonard A.; Peplinski, William J.; Roach, Jesse D.; Brainard, James Robert; West, Todd H.; Schoenwald, David Alan

    2009-12-01

    An initial version of a Systems Dynamics (SD) modeling framework was developed for the analysis of a broad range of energy technology and policy questions. The specific question selected to demonstrate this process was 'what would be the carbon and import implications of expanding nuclear electric capacity to provide power for plug in hybrid vehicles?' Fifteen SNL SD energy models were reviewed and the US Energy and Greenhouse gas model (USEGM) and the Global Nuclear Futures model (GEFM) were identified as the basis for an initial modeling framework. A basic U.S. Transportation model was created to model U.S. fleet changes. The results of the rapid adoption scenario result in almost 40% of light duty vehicles being PHEV by 2040 which requires about 37 GWy/y of additional electricity demand, equivalent to about 25 new 1.4 GWe nuclear plants. The adoption rate of PHEVs would likely be the controlling factor in achieving the associated reduction in carbon emissions and imports.

  14. Should the strategic trade policy be considered obsolete or should it be redefined based on the current circumstances?

    Directory of Open Access Journals (Sweden)

    Julián Salinas Ventura

    2014-08-01

    Full Text Available This paper discusses the relevance of the strategic trade policy in the economies in Latin American countries, who have signed several trade agreements bilaterally and multilaterally. These agreements limit the policies that can be implemented and mostly do not consider the countries’ specific circumstances. However, it is important to discuss the problem of dependency and its specific manifestations, especially when talking about the Latin American countries’ integration into international trade.The strategic trade policy really needs to be redefined to take global context into consideration and to implement policies that have trade impact on strategic economic sectors, based on a deliberate development strategy. 

  15. "Use of Current Best Evidence": Promises and Illusions, Limitations and Contradictions in the Triangle of Research, Policy and Practice

    Science.gov (United States)

    Lassnigg, Lorenz

    2012-01-01

    This paper explores the methodological and epistemological implications of the relationships between R&D, policy and practice. The proposals towards "evidence-based policy and practice" are analysed with respect to this triangle from three angles: (1) meaning; (2) production; and (3) use of evidence. A comprehensive model of the…

  16. Current Policy and Legislation in England Regarding Older People--What This Means for Older People with Learning Disabilities: A Discussion Paper

    Science.gov (United States)

    Turner, Sue; Cooper Ueki, Madeline

    2015-01-01

    Background: This paper seeks to explore the opportunities and challenges generated by current policy, guidance and legislation in England relating to older people, in terms of the practical implications for older people with learning disabilities. Methods: Using the broad themes housing, employment, social inclusion and isolation, care and…

  17. Osteoporosis: Therapeutic Options.

    Science.gov (United States)

    Ivanova, Stefka; Vasileva, Liliya; Ivanova, Stanislava; Peikova, Lily; Obreshkova, Danka

    2015-01-01

    The definition of osteoporosis was originally formulated at a conference of the World Health Organization (WHO) in 1993 as 'a systemic skeletal disease characterized by decreased bone mass and altered micro-architecture of bone tissue, leading to enhanced bone fragility and risk of fractures'. Osteoporosis is characterized by low bone mineral density (BMD) and loss of the structural and bio-mechanical properties that are required to maintain bone homeostasis. This review aims to address the currently available options in prevention and treatment of osteoporosis. Management of osteoporosis includes non-pharmacological treatment - diet rich of calcium and vitamin D, healthy lifestyle, proper exercise plan, and pharmacological therapy. Combination of non-pharmacological and pharmacological treatment options have to be considered for prevention of osteoporosis and minimization of the risk of fractures. Given the heterogeneity of osteoporosis syndrome and lack of significant number of comparative studies, the choice of a pharmacological agents should be individualized.

  18. Osteoporosis: Therapeutic Options

    Directory of Open Access Journals (Sweden)

    Ivanova Stefka

    2015-12-01

    Full Text Available The definition of osteoporosis was originally formulated at a conference of the World Health Organization (WHO in 1993 as ‘a systemic skeletal disease characterized by decreased bone mass and altered micro-architecture of bone tissue, leading to enhanced bone fragility and risk of fractures’. Osteoporosis is characterized by low bone mineral density (BMD and loss of the structural and bio-mechanical properties that are required to maintain bone homeostasis. This review aims to address the currently available options in prevention and treatment of osteoporosis. Management of osteoporosis includes non-pharmacological treatment - diet rich of calcium and vitamin D, healthy lifestyle, proper exercise plan, and pharmacological therapy. Combination of non-pharmacological and pharmacological treatment options have to be considered for prevention of osteoporosis and minimization of the risk of fractures. Given the heterogeneity of osteoporosis syndrome and lack of significant number of comparative studies, the choice of a pharmacological agents should be individualized.

  19. Modulation of the activity of N-methyl-d-aspartate receptors as a novel treatment option for depression: current clinical evidence and therapeutic potential of rapastinel (GLYX-13)

    Science.gov (United States)

    Vasilescu, Andrei-Nicolae; Schweinfurth, Nina; Borgwardt, Stefan; Gass, Peter; Lang, Undine E; Inta, Dragos; Eckart, Sarah

    2017-01-01

    Classical monoaminergic antidepressants show several disadvantages, such as protracted onset of therapeutic action. Conversely, the fast and sustained antidepressant effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine raises vast interest in understanding the role of the glutamate system in mood disorders. Indeed, numerous data support the existence of glutamatergic dysfunction in major depressive disorder (MDD). Drawback to this short-latency therapy is its side effect profile, especially the psychotomimetic action, which seriously hampers the common and widespread clinical use of ketamine. Therefore, there is a substantial need for alternative glutamatergic antidepressants with milder side effects. In this article, we review evidence that implicates NMDARs in the prospective treatment of MDD with focus on rapastinel (formerly known as GLYX-13), a novel synthetic NMDAR modulator with fast antidepressant effect, which acts by enhancing NMDAR function as opposed to blocking it. We summarize and discuss current clinical and animal studies regarding the therapeutic potential of rapastinel not only in MDD but also in other psychiatric disorders, such as obsessive–compulsive disorder and posttraumatic stress disorder. Additionally, we discuss current data concerning the molecular mechanisms underlying the antidepressant effect of rapastinel, highlighting common aspects as well as differences to ketamine. In 2016, rapastinel received the Breakthrough Therapy designation for the treatment of MDD from the US Food and Drug Administration, representing one of the most promising alternative antidepressants under current investigation.

  20. Return migration in Western Europe: current policy trends and their implications, in particular for the second generation.

    Science.gov (United States)

    Entzinger, H

    1985-06-01

    Return migration in Western Europe is examined, with a focus on government policy trends and their implications. The need for international cooperation between sending and receiving countries is emphasized. The effects of migration policies on migrants now and in the future are analyzed. Particular attention is paid to the questions posed by the expressed desire of a significant percentage of second-generation migrants to return to the countries of their parents' origin. (summary in FRE, SPA)

  1. Modulation of the activity of N-methyl-D-aspartate receptors as a novel treatment option for depression: current clinical evidence and therapeutic potential of rapastinel (GLYX-13

    Directory of Open Access Journals (Sweden)

    Vasilescu AN

    2017-03-01

    Full Text Available Andrei-Nicolae Vasilescu,1,* Nina Schweinfurth,2,* Stefan Borgwardt,2,* Peter Gass,1 Undine E Lang,2,* Dragos Inta,1,2,* Sarah Eckart2,* 1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; 2Department of Psychiatry (Universitäre Psychiatrische Kliniken, University of Basel, Basel, Switzerland *These authors contributed equally to this work Abstract: Classical monoaminergic antidepressants show several disadvantages, such as protracted onset of therapeutic action. Conversely, the fast and sustained antidepressant effect of the N-methyl-d-aspartate receptor (NMDAR antagonist ketamine raises vast interest in understanding the role of the glutamate system in mood disorders. Indeed, numerous data support the existence of glutamatergic dysfunction in major depressive disorder (MDD. Drawback to this short-latency therapy is its side effect profile, especially the psychotomimetic action, which seriously hampers the common and widespread clinical use of ketamine. Therefore, there is a substantial need for alternative glutamatergic antidepressants with milder side effects. In this article, we review evidence that implicates NMDARs in the prospective treatment of MDD with focus on rapastinel (formerly known as GLYX-13, a novel synthetic NMDAR modulator with fast antidepressant effect, which acts by enhancing NMDAR function as opposed to blocking it. We summarize and discuss current clinical and animal studies regarding the therapeutic potential of rapastinel not only in MDD but also in other psychiatric disorders, such as obsessive–compulsive disorder and posttraumatic stress disorder. Additionally, we discuss current data concerning the molecular mechanisms underlying the antidepressant effect of rapastinel, highlighting common aspects as well as differences to ketamine. In 2016, rapastinel received the Breakthrough Therapy designation for the treatment

  2. Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins.

    Science.gov (United States)

    El Harchaoui, Karim; Akdim, Fatima; Stroes, Erik S G; Trip, Mieke D; Kastelein, John J P

    2008-01-01

    Low-density lipoprotein-cholesterol (LDL-C) lowering is the mainstay of the current treatment guidelines in the management of cardiovascular risk. HMG-CoA reductase inhibitors (statins) are currently the most effective LDL-C-lowering drugs. However, a substantial number of patients do not reach treatment targets with statins. Therefore, an unmet medical need exists for lipid-lowering drugs with novel mechanisms of action to reach the recommended cholesterol target levels, either by monotherapy or combination therapy. Upregulation of the LDL receptor with squalene synthase inhibitors has shown promising results in animal studies but the clinical development of the lead compound lapaquistat (TAK-475) has recently been discontinued. Ezetimibe combined with statins allowed significantly more patients to reach their LDL-C targets. Other inhibitors of intestinal cholesterol absorption such as disodium ascorbyl phytostanol phosphate (FM-VP4) and bile acid transport inhibitors have shown positive results in early development trials, whereas the prospect of acyl coenzyme A: cholesterol acyltransferase inhibition in cardiovascular prevention is dire. Selective inhibition of messenger RNA (mRNA) by antisense oligonucleotides is a new approach to modify cholesterol levels. The inhibition of apolipoprotein B mRNA is in advanced development and mipomersen sodium (ISIS 301012) has shown striking results in phase II studies both as monotherapy as well as in combination with statins.

  3. An Empirical Analysis of the Accounting Policy Option and Tax Planning%会计政策选择与企业税务筹划的实证分析

    Institute of Scientific and Technical Information of China (English)

    方东霖; 陈华

    2015-01-01

    The correlation relationship exits between the tax planning and the accounting policy option. In this paper, we select the actual income tax burden ETR as the dependent variable, the amount of impairment of assets, depreciation of fixed assets and inventory valuation method as the independent variable, adopt the data of Shanghai Stock Exchange all A-share listed companies in 2013 by some associated processing as the sample data, conduct a correlation analysis and regression analysis and draw a conclusion in the end. Then we take some further expansion analysis for these conclusions and point out its limitations.%理论上会计政策选择与企业税务筹划之间的存在相关性关系.本文选取实际所得税税负ETR作为应变量、资产减值准备额、固定资产折旧额和存货计价方法作为自变量,采用2013年上海证券交易所全部A股上市公司数据并进行相关处理后作为样本数据,进行了相关系数分析和回归分析,得出实证结论. 接下来还对这些实证分析结论做进一步的拓展分析,并指出其局限性.

  4. 风险规避假定下对回购策略以及期权策略的不同影响%Distinct impacts on return policy and option contracts with risk-averse agents

    Institute of Scientific and Technical Information of China (English)

    程永文; 周永务

    2013-01-01

    The paper established a utility function of containing the surplus risk and shortage risk to find the impacts on the supply chain coordination given different risk preference. By comparing the coordination strategies about return policy and option contracts given the agents being risk-neutrality or risk-averse, it gives the optimal prices of buyback contracts and option contracts and approach the following results: 1) In option contracts, the manufacturer does not need to guess the risk attitude of the retailer. 2) Whatever the risk attitude is, there is a rule that the higher the controlling coefficient is, the better coordination is, the more profit is. 3) Given the risk-averse agents it shows that the profit of the centralized supply chain is not affirmatively higher than the profit of decentralized supply chain. Therefore, with the risk-averse agents various coordinated policies show distinct effects. It also provides important methods for the similar research.%为了发现风险规避对不同协调合约的影响,在设计效用函数时,同时考虑了订购过剩风险和短缺风险,建立风险中性和风险规避情形下回购合约和期权合约的协调策略模型,给出回购合约和期权合约在不同风险假定下制造商的最优定价策略,并得出如下结论:1)在期权合约中制造商制定价格可以不用考虑零售商的风险态度;2)无论风险态度如何,在两种合约中皆表现为控制系数(表示垄断程度)越高,越容易趋近完美协调,供应链系统利润也越高;3)在风险规避假定下,比较了集中供应链和分散供应链的系统效率,发现集中供应链系统利润并非必然高于分散供应链的利润,这取决于决策者的风险规避程度.因此,在风险规避的假定下,不同供应链协调策略表现为极其不同的性质,为以后此类研究提供了重要线索.

  5. Concomitant contraceptive implant and efavirenz use in women living with HIV: perspectives on current evidence and policy implications for family planning and HIV treatment guidelines

    Directory of Open Access Journals (Sweden)

    Rena C. Patel

    2017-05-01

    Conclusion: This controversy underlines the importance of integrating family planning services into routine HIV care, counselling women appropriately on increased risk of pregnancy with concomitant implant and efavirenz use, and expanding contraceptive method mix for all women. As global access to ART expands, greater research is needed to explore implant effectiveness when used concomitantly with newer ART regimens. Data on how HIV-positive women and their partners choose contraceptives, as well as information from providers on how they present and counsel patients on contraceptive options are needed to help guide policy and service delivery. Lastly, greater collaboration between HIV and reproductive health experts at all levels are needed to develop successful strategies to ensure the best HIV and reproductive health outcomes for women living with HIV.

  6. Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy

    Directory of Open Access Journals (Sweden)

    Álvaro Moncayo

    2009-07-01

    worldwide network of laboratories that carried out basic and applied research supporting the planning and evaluation of national Chagas disease control programmes. The present article reviews the current epidemiological trends for Chagas disease in Latin America and the future challenges in terms of epidemiology, surveillance and health policy.

  7. Policy analysis for delivery of contagious bovine pleuropneumonia control strategies in sub-Saharan Africa.

    Science.gov (United States)

    Onono, J O; Wieland, B; Suleiman, A; Rushton, J

    2017-04-01

    This paper presents a policy analysis for the implementation of contagious bovine pleuropneumonia (CBPP) control strategies in pastoral regions of sub-Saharan Africa, where the disease is endemic. A framework for policy analysis was adapted for this review. The framework has eight principal steps: defining the context of the policy, identifying the problem to be addressed by the policy, searching for evidence of the problem, identifying policy options, projecting policy outcomes, evaluating the potential policy options, weighing their outcomes and making the policy decision. The data and information used to search for evidence of the problem, options for solving the problem, and the projected outcomes of those options were obtained from both published and grey sources of literature. The policy problem for CBPP control in sub-Saharan Africa was identified as a failure to deliver control services to farmers whose cattle are at high risk of exposure to infection. The authors suggest the adoption of signed contractual agreements between the public and private sectors to support the vaccination of susceptible herds raised in endemic regions. Implementation of this policy will increase vaccination coverage of susceptible cattle herds since current vaccination coverage is low.

  8. Policy and Financing – Why is Sea Transport Currently Invisible in the Search for a Low Carbon Future for Pacific Island Countries?

    Directory of Open Access Journals (Sweden)

    Peter Roger Nuttall

    2014-07-01

    Full Text Available The role of financing and policy in research, development, trialling and introduction of renewable energy technologies in the Pacific maritime sector is considered. Key research and trials of renewable energy technologies for sea transport in the Pacific from the 1980s and the critical role played by agencies such as the United Nations in leveraging support from funders such as the Asian Development Bank and European Union are reviewed. The lack of current policy on potential renewable energy technology use in sea transport at national, regional and development agency levels is discussed with the Asian Development Bank used as a case study. The urgent need for such technology to be commercially trialled as a means of reducing the region’s dependency on fossil fuels given the importance of sea transport to socio-economic development in the Pacific is outlined in light of the proportion of fossil fuel currently used by the maritime sector. The paper concludes that review of current funding strategies and policies to include both sea transport and the potential for use of renewable energy technologies in the maritime sector in the Pacific is a priority and current reliance on the private sector acting alone needs review.

  9. CHOICE OPTIONS TO MEET HOUSEHOLD FOOD SECURITY IN THE CATTLE CORRIDOR OF UGANDA

    Directory of Open Access Journals (Sweden)

    Betty Mbolanyi

    2017-01-01

    Full Text Available This study identified the major options adopted by households in the rangelands of Uganda to meet their food needs, the factors that affect their choices and barriers to making use of various choices. A cross-sectional survey using semi-structured questionnaires was administered among 180 pastoral households in selected rangeland area of Uganda. The options identified include restocking animals, changing planting dates, soil conservation, harnessing new technologies, planting trees and buying food stuffs. Analysis of results from the multinomial logistic model indicated that age, level of education, size of household, years in current location, farm income, non-farm income, livestock ownership, access to extension services and climate and weather information were key determinants of farmers’ choice of options to realize household food security. The major perceived barriers to choice options were lack of information on alternative options, poor technologies, climate variability, inadequate land, high food prices and low income. The analysis of choice of options to meet household food security suggests a number of different policy options such as strengthening production facilitation options available to pastoral communities including among others access to affordable credit, investing in yield-increasing technologies, introduction of livestock species that are better suited to drier conditions, raising awareness on climate related variations, creating opportunities for off-farm employment, encouraging pastoralists to grow more crops, and investing in irrigation.

  10. Making real options really work.

    Science.gov (United States)

    van Putten, Alexander B; MacMillan, Ian C

    2004-12-01

    As a way to value growth opportunities, real options have had a difficult time catching on with managers. Many CFOs believe the method ensures the overvaluation of risky projects. This concern is legitimate, but abandoning real options as a valuation model isn't the solution. Companies that rely solely on discounted cash flow (DCF) analysis underestimate the value of their projects and may fail to invest enough in uncertain but highly promising opportunities. CFOs need not--and should not--choose one approach over the other. Far from being a replacement for DCF analysis, real options are an essential complement, and a project's total value should encompass both. DCF captures a base estimate of value; real options take into account the potential for big gains. This is not to say that there aren't problems with real options. As currently applied, they focus almost exclusively on the risks associated with revenues, ignoring the risks associated with a project's costs. It's also true that option valuations almost always ignore assets that an initial investment in a subsequently abandoned project will often leave the company. In this article, the authors present a simple formula for combining DCF and option valuations that addresses these two problems. Using an integrated approach, managers will, in the long run, select better projects than their more timid competitors while keeping risk under control. Thus, they will outperform their rivals in both the product and the capital markets.

  11. Current use of impact models for agri-environment schemes and potential for improvements of policy design and assessment

    DEFF Research Database (Denmark)

    Primdahl, Jorgen; Vesterager, Jens Peter; Finn, John A.

    2010-01-01

    Agri-Environment Schemes (AES) to maintain or promote environmentally-friendly farming practices were implemented on about 25% of all agricultural land in the EU by 2002. This article analyses and discusses the actual and potential use of impact models in supporting the design, implementation...... and evaluation of AES. Impact models identify and establish the causal relationships between policy objectives and policy outcomes. We review and discuss the role of impact models at different stages in the AES policy process, and present results from a survey of impact models underlying 60 agri-environmental...... schemes in seven EU member states. We distinguished among three categories of impact models (quantitative, qualitative or common sense), depending on the degree of evidence in the formal scheme description, additional documents, or key person interviews. The categories of impact models used mainly...

  12. organic agriculture in Syria : policy options

    OpenAIRE

    Santucci, Fabio M.

    2010-01-01

    The author analyses present difficulties of conventional agriculture in Syria. Market opportunities, in Syria and abroad, are illustrated. Possible actions and participatory approach are thus covered.

  13. Future Options for Swedish Security Policy

    Science.gov (United States)

    2007-11-02

    14 General European Dogan Harris Kelleher Larrabee Lynn-Jones Murray Roper Asmus Barry Dornbusch Driscoll Feldtstein Flockhart...no. 6 (November/December 1997): 60. 21 Dornbusch , 114-116. 22 Feldstein, 61. 23 Ibid. 24 Ibid., 12. 25 Ham, 531. 26 Ibid. 27 Kelleher, 3...1993): 71-89. Dornbusch , Rudi. ’TEuro Fantasies." Foreign Affairs. Vol. 75, No. 5 (September/October 1996): 110-124 Driscoll, R. F. "European Security

  14. Arctic Region Policy: Information Sharing Model Options

    Science.gov (United States)

    2010-09-01

    specializations , meaning that expertise is not blended into a process that focuses on one sector over another. Figure 25 highlights APIP’s ability to...8 Figure 5. 2004 Arctic Maritime Activity (From Treadwell, 2009, p. 48) .............. 10 Figure 6. Explorer Stuck in the Antarctic (From New...been a Titanic situation, such as what happened to the cruise ship EXPLORER in the Antarctic in November 2007 as shown in Figure 6 (Browley & 11

  15. Policy Options for Reducing CO2 Emissions

    Science.gov (United States)

    2008-02-01

    countries, such as financing a low-emission power plant in China. 7. See Joseph E. Aldy, Peter R. Orszag, and Joseph E. Stiglitz , “Cli- mate Change: An...tives—see Joseph E. Aldy, Peter R. Orszag, and Joseph E. Stiglitz , “Climate Change: An Agenda for Global Collective Action” (paper prepared for the...written by Terry Dinan of CBO’s Microeconomic Studies Division under the guidance of Joseph Kile and David Moore. Robert Dennis, Douglas Hamilton

  16. Current and emerging treatment options for ANCA-associated vasculitis: potential role of belimumab and other BAFF/APRIL targeting agents

    Directory of Open Access Journals (Sweden)

    Lenert A

    2015-01-01

    Full Text Available Aleksander Lenert,1 Petar Lenert21Division of Rheumatology, University of Kentucky, Kentucky Clinic, Lexington, KY, USA; 2Division of Immunology, Department of Internal Medicine, The University of Iowa, Iowa City, IA, USAAbstract: Antineutrophil cytoplasmic antibody (ANCA-associated vasculitis (AAV comprises several clinical entities with diverse clinical presentations, outcomes, and nonunifying pathogenesis. AAV has a clear potential for relapses, and shows unpredictable response to treatment. Cyclophosphamide-based therapies have remained the hallmark of induction therapy protocols for more than four decades. Recently, B-cell depleting therapy with the anti-CD20 antibody rituximab has proved beneficial in AAV, leading to Food and Drug Administration approval of rituximab in combination with corticosteroids for the treatment of AAV in adults. Rituximab for ANCA-associated vasculitis and other clinical trials provided clear evidence that rituximab was not inferior to cyclophosphamide for remission induction, and rituximab appeared even more beneficial in patients with relapsing disease. This raised hopes that other B-cell-targeted therapies directed either against CD19, CD20, CD22, or B-cell survival factors, B-cell activating factor of the tumor necrosis factor family (BAFF and a proliferation-inducing ligand could also be beneficial for the management of AAV. BAFF neutralization with the fully humanized monoclonal antibody belimumab has already shown success in human systemic lupus erythematosus and, along with another anti-BAFF reagent blisibimod, is currently undergoing Phase II and III clinical trials in AAV. Local production of BAFF in granulomatous lesions and elevated levels of serum BAFF in AAV provide a rationale for BAFF-targeted therapies not only in AAV but also in other forms of vasculitis such as Behcet’s disease, large-vessel vasculitis, or cryoglobulinemic vasculitis secondary to chronic hepatitis C infection. BAFF

  17. New environmental policy instruments to realize forest expansion in Flanders (northern Belgium): A base for smart regulation?

    NARCIS (Netherlands)

    Gossum, Van P.; Ledene, L.; Arts, B.J.M.; Vreese, De R.; Langenhove, Van G.; Verheyen, K.

    2009-01-01

    This paper evaluates the current instrument mix, designs options for smart regulation and estimates the support base of new instruments for the forest expansion policy in Flanders (northern Belgium). The framework applied is a combination of theories on instrument choice (ICT), policy transfer and l

  18. Policy Reform Efforts and Equal Opportunity – An Evidence-Based Link? An Analysis of Current Sector Reforms in the Austrian School System

    Directory of Open Access Journals (Sweden)

    Corinna Geppert

    2012-01-01

    Full Text Available The main focus of the present paper is to answer two different questions: From the perspective of Austrian education policy, which core areas of schooling are linked to the demand for equal opportunity? Can these reform efforts sustain the current state of research, and what are the consequences for schooling? The paper draws on an analysis by Hopmann, Geppert & Bauer (2010. Fifteen official self-presentations (political programmes of Austrian political parties were analysed for statements concerning the improvement of the education system. This resulted in about seventy different statements, which were aggregated into eight core areas.We conducted a systematic analysis of four of these core areas, dealing with the topics of equal opportunity: comprehensive school, all-day schooling, school autonomy and standardisation of students’ achievements. The aim was not to judge the legitimacy or the political content of the claims made. In line with evaluative discourse, we asked whether the combination of political demands and their associated expectations met the current state of research. In many policy programmes, it is assumed that comprehensive schooling, all-day schooling, education standards, standardised general certification for university attendance, school autonomy or language surveys go hand in hand with more equality of opportunity, justice andquality in education, but an analysis of the current state of research could not confirm this. The analysis showed that, with regard to education policy demands, statements having empirically little or nothing to do with each other are often linked.

  19. Analysis of Options Contract, Option Pricing in Agricultural Products

    Directory of Open Access Journals (Sweden)

    H. Tamidy

    2016-03-01

    of standardizing the underlying asset 4- Impossibility of creating cross supply of the underlying asset In addition, after the introduction of the model parameters, we offers method calculating of the volatility (standard deviation price with using historical data (time series. Parameters of Blk- Scholes model are introduced and option contract of selected product will pricing. After effect of the rise and fall agreement prices (in the form of 9-defined scenario on the price of put option and sales option are studied. In this study, after forming the hypothetical option market for the Canola, option pricing is done. In this section, the criteria for selecting an appropriate asset base is expressed for option contract. The Black–Scholes model is introduced for the valuation of call option and European put option contract. After introducing the model parameters, the calculation of volatility (standard deviation of price using historical data (time series is presented .To achieve this aim, the Black – Scholes model was used under 9 strike price scenario of 5, 10, 15, 20 percent above; 5, 10, 15, and 20 percent lower and finally equal to current prices. This model was run in Excel 2010 and Derivea gem 1.5. Results and Discussion: The results showed 43% price volatility for canola that reflects uncertainty in its price. In the next stage of pricing, the purchase and sale of the selected product was done under the nine price scenarios. The results showed that the highest authority to purchase option was for scenario K1 and the highest buy option was for the K9 scenario. The least expensive buy option is K9 and the least expensive sell option is K1. Conclusion: The results show that the increase of strike price under these scenarios leads to a decrease of call option price and decrease of put option price. In addition, the farmers, businesspersons and agricultural products transforming factories with a different degree of risk disclosure can participate in these markets

  20. CONDITIONAL ASIAN OPTIONS

    OpenAIRE

    Runhuan Feng; Volkmer, Hans W.

    2015-01-01

    Conditional Asian options are recent market innovations, which offer cheaper and long-dated alternatives to regular Asian options. In contrast with payoffs from regular Asian options which are based on average asset prices, the payoffs from conditional Asian options are determined only by average prices above certain threshold. Due to the limited inclusion of prices, conditional Asian options further reduce the volatility in the payoffs than their regular counterparts and have been promoted i...

  1. Cost-effectiveness analysis of Option B+ for HIV prevention and treatment of mothers and children in Malawi.

    Directory of Open Access Journals (Sweden)

    Olufunke Fasawe

    Full Text Available BACKGROUND: The Ministry of Health in Malawi is implementing a pragmatic and innovative approach for the management of all HIV-infected pregnant women, termed Option B+, which consists of providing life-long antiretroviral treatment, regardless of their CD4 count or clinical stage. Our objective was to determine if Option B+ represents a cost-effective option. METHODS: A decision model simulates the disease progression of a cohort of HIV-infected pregnant women receiving prophylaxis and antiretroviral therapy, and estimates the number of paediatric infections averted and maternal life years gained over a ten-year time horizon. We assess the cost-effectiveness from the Ministry of Health perspective while taking into account the practical realities of implementing ART services in Malawi. RESULTS: If implemented as recommended by the World Health Organization, options A, B and B+ are equivalent in preventing new infant infections, yielding cost effectiveness ratios between US$ 37 and US$ 69 per disability adjusted life year averted in children. However, when the three options are compared to the current practice, the provision of antiretroviral therapy to all mothers (Option B+ not only prevents infant infections, but also improves the ten-year survival in mothers more than four-fold. This translates into saving more than 250,000 maternal life years, as compared to mothers receiving only Option A or B, with savings of 153,000 and 172,000 life years respectively. Option B+ also yields favourable incremental cost effectiveness ratios (ICER of US$ 455 per life year gained over the current practice. CONCLUSION: In Malawi, Option B+ represents a favorable policy option from a cost-effectiveness perspective to prevent future infant infections, save mothers' lives and reduce orphanhood. Although Option B+ would require more financial resources initially, it would save societal resources in the long-term and represents a strategic option to simplify and

  2. Current use of impact models for agri-environment schemes and potential for improvements of policy design and assessment.

    Science.gov (United States)

    Primdahl, Jørgen; Vesterager, Jens Peter; Finn, John A; Vlahos, George; Kristensen, Lone; Vejre, Henrik

    2010-06-01

    Agri-Environment Schemes (AES) to maintain or promote environmentally-friendly farming practices were implemented on about 25% of all agricultural land in the EU by 2002. This article analyses and discusses the actual and potential use of impact models in supporting the design, implementation and evaluation of AES. Impact models identify and establish the causal relationships between policy objectives and policy outcomes. We review and discuss the role of impact models at different stages in the AES policy process, and present results from a survey of impact models underlying 60 agri-environmental schemes in seven EU member states. We distinguished among three categories of impact models (quantitative, qualitative or common sense), depending on the degree of evidence in the formal scheme description, additional documents, or key person interviews. The categories of impact models used mainly depended on whether scheme objectives were related to natural resources, biodiversity or landscape. A higher proportion of schemes dealing with natural resources (primarily water) were based on quantitative impact models, compared to those concerned with biodiversity or landscape. Schemes explicitly targeted either on particular parts of individual farms or specific areas tended to be based more on quantitative impact models compared to whole-farm schemes and broad, horizontal schemes. We conclude that increased and better use of impact models has significant potential to improve efficiency and effectiveness of AES. (c) 2009 Elsevier Ltd. All rights reserved.

  3. Voucher Programs. Policy Analysis

    Science.gov (United States)

    Wixom, Micah Ann

    2017-01-01

    This education Policy Analysis provides a comprehensive look at eligibility requirements, accountability and funding for voucher programs across the states, and includes research findings and legal challenges for this private school choice option.

  4. Tularemia: Current Diagnosis and Treatment Options

    Science.gov (United States)

    2008-04-01

    PCR-enzyme immunoassay : tul4  CFU for both assays Successful detection of F. tularensis in mouse tissue and ticks [90] Junhui et al. Three primers...Akalin H, Oral HB . Tularemia in Bursa, Turkey: 205 cases in 10 years. Eur. J. Epidemiol. 16, 271–276 (2000). 85 Feldman KA, Enscore RE, Lathrop

  5. Current and future treatment options for acne.

    NARCIS (Netherlands)

    Kerkhof, P.C.M. van de; Kleinpenning, M.M.; Jong, E.M.G.J. de; Gerritsen, M.J.P.; Dooren-Greebe, R.J. van; Alkemade, J.A.C.

    2006-01-01

    Acne is a frequent skin disease with abnormalities in the process of keratinization, sebaceous gland functioning and inflammation. In this review, our understanding of the pathogenesis of acne has been updated. An overview of efficacy and side effects of available anti-acne treatments is presented.

  6. Current and future treatment options in osteoporosis.

    LENUS (Irish Health Repository)

    Brewer, Linda

    2011-04-01

    The incidence of osteoporosis-related fractures will increase substantially over the coming decades as the population ages globally. This has important economic and public health implications, contributing substantially to morbidity and excess mortality in this population.

  7. [Hilar cholangiocarcinoma (Klatskin tumor) - current treatment options].

    Science.gov (United States)

    Bělina, F

    2013-01-01

    Hilar cholangiocarcinoma is a rare tumor with a rather poor prognosis, and thus remains a challenge for diagnosis and treatment. The sole potentionally curative treatment is the complete resection of the tumor. A negative surgical margin is one of the most important factors in achieving prolonged survival. A preoperative evaluation of the tumor is important for the evaluation of resectability and the extent of surgery. Unfortunately, only a small number of patients with hilar cholangiocarcinoma is indicated for the radical procedure. Liver transplantation is not a standard method in the treatment of the Klatskin tumor and it is reserved only for carefully selected patients in a few transplant centres. The main aim of the palliative treatment is biliary drainage, reduction of the pain and pruritus and overall improvement of the quality of life. Adjuvant chemotherapy and radiotherapy are the important parts of the complex therapy, however, no definite regimen has been established to date. Further evidence is needed to define the role of liver transplantation and (neo)adjuvant new therapeutic modalities. Key words: hilar cholangiocarcinoma - radical surgery - palliative treatment - liver transplantation - (neo) adjuvant chemotherapy - radiotherapy.

  8. Achondroplasia: Current Options and Future Perspective.

    Science.gov (United States)

    Bouali, Houda; Latrech, Hanane

    2015-06-01

    Achondroplasia is a human bone genetic disorder of the growth plate and is the most common form of inherited disproportionate short stature. It is inherited as an autosomal dominant disease with essentially complete penetrance. Of these most have the same point mutation in the gene for fibroblast growth factor receptor 3 (FGFR3) which is a negative regulator of bone growth. The clinical and radiological features of achondroplasia can easily be identified; they include disproportionate short stature with rhizomelic shortening, macrocephaly with frontal bossing, midface hypoplasia, lumbar hyperlordosis, and a trident hand configuration. The majority of achondroplasts have a normal intelligence, but many social and medical complications may compromise a full and productive life. Some of them have serious health consequences related to hydrocephalus, craniocervical junction compression, or upper-airway obstruction. In this article, we discuss a number of treatments from the surgical limb lengthening approach and the Recombinant Growth Hormone (rhGH) treatment, to future treatments, which include the Natriuretic Peptide C-type (CNP). The discussion is a comparative study of the complications and drawbacks of various experiments using numerous strategies.

  9. Birdshot uveitis: current and emerging treatment options

    Directory of Open Access Journals (Sweden)

    Menezo V

    2013-12-01

    Full Text Available Victor Menezo,1,2 Simon RJ Taylor3,4 1Institut Catala de Retina, Barcelona, Spain; 2Department of Ophthalmology, Provincial Hospital Consortium Castellon, Castello, Spain; 3Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK; 4Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK Abstract: Birdshot chorioretinopathy is a relatively uncommon subtype of idiopathic posterior uveitis with distinct clinical characteristics and a strong genetic association with the Human Leukocyte Antigen (HLA-A29 allele. The diagnosis remains clinical and is based on the presence of typical clinical features, including multiple, distinctive, hypopigmented choroidal lesions throughout the fundus. The long-term visual prognosis of this disorder, however, remains guarded – central visual acuity can be preserved until late in the disease and it is not uncommon for patients to receive inadequate immunosuppressive treatment, leading to a poor long-term outcome in which peripheral retinal damage eventually leads to visual deterioration. Birdshot chorioretinopathy has proven a particularly attractive area of study within the field of uveitis, as it is a relatively easily defined disease with an associated human leukocyte antigen haplotype. Despite this, however, the immune mechanisms involved in its pathogenesis remain unclear, and some patients continue to lose retinal function despite therapy with corticosteroids and conventional immunosuppressive agents. Laboratory research continues to investigate the underlying mechanisms of disease, and clinical research is now being driven to improve the phenotyping and monitoring of this condition as, in the era of so-called personalized medicine, it is becoming increasingly important to identify patients at risk of visual loss early so that they can be treated more aggressively with targeted therapies such as the newer biological agents. This approach requires the formation of collaborative groups, as the relative rarity of the condition makes it difficult for one center to accumulate enough patients for worthwhile studies. Nevertheless, results obtained with newer therapies, such as biological agents directed against particular cytokines or cell-surface receptors, demonstrate ever improving control of the inflammation in refractory cases, providing hope that the outlook for visual function in this condition can only improve. Keywords: birdshot chorioretinopathy, HLA-A29, retinal vasculitis, Th17 cells, monoclonal antibodies, interleukin antagonists

  10. Birdshot uveitis: current and emerging treatment options

    OpenAIRE

    Menezo V; Taylor SRJ

    2013-01-01

    Victor Menezo,1,2 Simon RJ Taylor3,4 1Institut Catala de Retina, Barcelona, Spain; 2Department of Ophthalmology, Provincial Hospital Consortium Castellon, Castello, Spain; 3Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK; 4Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK Abstract: Birdshot chorioretinopathy is a relatively uncommon subtype of idiopathic posterior uveitis with distinct clinical characteristics and a strong genetic association wit...

  11. Breast reconstruction: current and future options

    Directory of Open Access Journals (Sweden)

    Paul Jr H

    2011-08-01

    Full Text Available Henry Paul Jr1, Tahira I Prendergast2, Bryson Nicholson2, Shenita White2, Wayne AI Frederick2,31Departments of Plastic Surgery, 2General Surgery, Howard University Hospital, 3Cancer Center, Howard University, Washington, DC, USAAbstract: When initiated by the devastating diagnosis of cancer, post ablative breast restoration has at its core the goal of restoring anatomic normalcy. The concepts of body image, wholeness, and overall well-being have been introduced to explain the paramount psychological influence the breast has on both individuals and society as a whole. Hence, a growing subspecialty has been established to recreate or simulate the lost breast. At least one third of breast cancer victims consider breast reconstruction. Breast reconstruction post mastectomy may be offered at the time of mastectomy or delayed post mastectomy after adjuvant therapy. This may be utilizing autologous tissues or implants and each has risks and benefits, especially when considering adjuvant therapy. In addition, there has been a move away from a traditional mastectomy to less invasive, but still curative procedures, such as skin-sparing and nipple-sparing mastectomy. These procedures provide the breast envelope to facilitate reconstruction. This paper reviews the primary issues in breast reconstruction, as well as their psychologic, oncologic, and social impact.Keywords: breast restoration, body image, breast reconstruction, mastectomy

  12. Breast reconstruction: current and future options

    OpenAIRE

    Paul Jr H; Prendergast TI; Nicholson B; White S; Frederick WA

    2011-01-01

    Henry Paul Jr1, Tahira I Prendergast2, Bryson Nicholson2, Shenita White2, Wayne AI Frederick2,31Departments of Plastic Surgery, 2General Surgery, Howard University Hospital, 3Cancer Center, Howard University, Washington, DC, USAAbstract: When initiated by the devastating diagnosis of cancer, post ablative breast restoration has at its core the goal of restoring anatomic normalcy. The concepts of body image, wholeness, and overall well-being have been introduced to explain the paramount psycho...

  13. Current management options for recurrent adrenocortical carcinoma

    Directory of Open Access Journals (Sweden)

    Glover AR

    2013-06-01

    Full Text Available Anthony R Glover,1 Julian C Y Ip,1 Jing Ting Zhao,1 Patsy S H Soon,1,4 Bruce G Robinson,1,3 Stan B Sidhu1,2 1Kolling Institute of Medical Research, Cancer Genetics Laboratory, 2Endocrine Surgical Unit, 3Department of Endocrinology, Royal North Shore Hospital and University of Sydney, St Leonards, 4Department of Surgery, Bankstown Hospital and University of New South Wales, Bankstown, NSW, Australia Abstract: Adrenal cortical carcinoma (ACC is a rare cancer that poses a number of management challenges due to the limited number of effective systemic treatments. Complete surgical resection offers the best chance of long-term survival. However, despite complete resection, ACC is associated with high recurrence rates. This review will discuss the management of recurrent ACC in adults following complete surgical resection. Management should take place in a specialist center and treatment decisions must consider the individual tumor biology of each case of recurrence. Given the fact that ACC commonly recurs, management to prevent recurrence should be considered from initial diagnosis with the use of adjuvant mitotane. Close follow up with clinical examination and imaging is important for early detection of recurrent disease. Locoregional recurrence may be isolated, and repeat surgical resection should be considered along with mitotane. The use of radiotherapy in ACC remains controversial. Systemic recurrence most often involves liver, pulmonary, and bone metastasis and is usually managed with mitotane, with or without combination chemotherapy. There is a limited role for surgical resection in systemic recurrence in selected patients. In all patients with recurrent disease, control of excessive hormone production is an important part of management. Despite intensive management of recurrent ACC, treatment failure is common and the use of clinical trials and novel treatment is an important part of management. Keywords: recurrence, surgery, chemotherapy, mitotane, treatment

  14. Current options for management of biliary atresia.

    Science.gov (United States)

    Gallo, Amy; Esquivel, Carlos O

    2013-03-01

    It is encouraging that we are improving the technical aspects of treatment modalities for biliary atresia. However, it is clear that more needs to be done to best develop new treatment plans while applying the modalities we have (porto-enterostomy or liver transplantation or both) in a way that will afford the best survival and quality-of-life. This review article will discuss a number of points that are vital to improving care and illustrates the need to further scrutinize treatment decisions.

  15. Current and future treatment options for acne.

    NARCIS (Netherlands)

    Kerkhof, P.C.M. van de; Kleinpenning, M.M.; Jong, E.M.G.J. de; Gerritsen, M.J.P.; Dooren-Greebe, R.J. van; Alkemade, J.A.C.

    2006-01-01

    Acne is a frequent skin disease with abnormalities in the process of keratinization, sebaceous gland functioning and inflammation. In this review, our understanding of the pathogenesis of acne has been updated. An overview of efficacy and side effects of available anti-acne treatments is presented.

  16. [Vertical talus: current diagnostic and therapy options].

    Science.gov (United States)

    Arbab, D; Rath, B; Quack, V; Lüring, C; Tingart, M

    2013-06-01

    Congenital vertical talus is a rare condition which presents as an isolated deformity or in association with neuromuscular and/or genetic disorders. Pathoanatomically the deformity shows a dislocated talonavicular and subtalar joint. The etiology and pathogenesis are still not finally determined although in some cases a genetic basis has been identified. The clinical picture is that of a flat, convex longitudinal arch with abduction and dorsiflexion of the forefoot and an elevated heel. Clinical diagnosis is confirmed by plain radiographic imaging. Congenital vertical talus should not be confused with other deformities of the foot, such as congenital oblique talus, flexible flat feet or pes calcaneus. The object of treatment of congenital vertical talus is to restore a normal anatomical relationship between the talus, navicular and calcaneus to obtain a pain-free foot. Major reconstructive surgery has been reported to be effective but is associated with substantial complications. Good early results of a modified non-operative treatment using serial manipulation, cast treatment and minimally invasive surgery may change therapeutic concepts.

  17. Current and future treatment options in SIADH

    NARCIS (Netherlands)

    R. Zietse (Robert); N. van der Lubbe (Nils); E.J. Hoorn (Ewout)

    2009-01-01

    textabstractThe treatment of hyponatraemia due to SIADH is not always as straightforward as it seems. Although acute treatment with hypertonic saline and chronic treatment with fluid restriction are well established, both approaches have severe limitations. These limitations are not readily overcome

  18. Opiate addiction - current trends and treatment options

    Directory of Open Access Journals (Sweden)

    Achal Bhatt

    2016-07-01

    Full Text Available Opioids are widely used drugs for treatment of pain and related disorders. Opiate addiction is a major public health concern in the United States causing significant increase in healthcare expenditure. They produce euphoria and sense of well-being which makes them addictive to some people. Used in higher doses they can lead to cardiac or respiratory compromise. They also impair cognition leading to impaired decision making. Opioids exert their effects by acting on three different types of receptors mu, delta, and kappa located on neuronal cell membranes causing inhibition of neurotransmitter release. Prolonged use of these drugs can lead to physical dependence causing withdrawal symptoms if a person stops using them. Commonly used medications to treat opiate addiction are methadone, LAAM (longer acting derivative of methadone, buprenorphine, and naltrexone. [Int J Res Med Sci 2016; 4(7.000: 2503-2507

  19. Evaluation of call options

    Institute of Scientific and Technical Information of China (English)

    陈道平

    2002-01-01

    The European and American call options,for which the prices of their underlying asset follow compound Poisson process,are evaluated by a probability method.Formulas that can be used to evaluate the options are obtained,which include not only the elements of an option:the price of the call option,the exercise price and the expiration date,but also the riskless interest rate,nevertheless exclude the volatility of the underlying asset.In practice,the evaluated results obtained by these formulas can proved references of making strategic decision for an investor who buys the call option and a company who sells the call option.

  20. AFCI Options Study

    Energy Technology Data Exchange (ETDEWEB)

    R. Wigeland; T. Taiwo; M. Todosow; W. Halsey; J. Gehin

    2009-09-01

    This report describes the background and framework for both organizing the discussion and providing information on the potential for nuclear energy R&D to develop alternative nuclear fuel cycles that would address the issues with the current implementations of nuclear power, including nuclear waste disposal, proliferation risk, safety, security, economics, and sustainability. The disposition of used fuel is the cause of many of the concerns, and the possible approaches to used fuel management identify a number of basic technology areas that need to be considered. The basic science in each of the technology areas is discussed, emphasizing what science is currently available, where scientific knowledge may be insufficient, and especially to identify specific areas where transformational discoveries may allow achievement of performance goals not currently attainable. These discussions lead to the wide range of technical options that have been the basis for past and current research and development on advanced nuclear fuel cycles in the United States. The results of this work are then briefly reviewed to show the extent to which such approaches are capable of addressing the issues with nuclear power, the potential for moving further, and the inherent limitations.