WorldWideScience

Sample records for current nde developments

  1. Advanced Eddy current NDE steam generator tubing.

    Energy Technology Data Exchange (ETDEWEB)

    Bakhtiari, S.

    1999-03-29

    As part of a multifaceted project on steam generator integrity funded by the U.S. Nuclear Regulatory Commission, Argonne National Laboratory is carrying out research on the reliability of nondestructive evaluation (NDE). A particular area of interest is the impact of advanced eddy current (EC) NDE technology. This paper presents an overview of work that supports this effort in the areas of numerical electromagnetic (EM) modeling, data analysis, signal processing, and visualization of EC inspection results. Finite-element modeling has been utilized to study conventional and emerging EC probe designs. This research is aimed at determining probe responses to flaw morphologies of current interest. Application of signal processing and automated data analysis algorithms has also been addressed. Efforts have focused on assessment of frequency and spatial domain filters and implementation of more effective data analysis and display methods. Data analysis studies have dealt with implementation of linear and nonlinear multivariate models to relate EC inspection parameters to steam generator tubing defect size and structural integrity. Various signal enhancement and visualization schemes are also being evaluated and will serve as integral parts of computer-aided data analysis algorithms. Results from this research will ultimately be substantiated through testing on laboratory-grown and in-service-degraded tubes.

  2. Probability of detection models for eddy current NDE methods

    Energy Technology Data Exchange (ETDEWEB)

    Rajesh, S.N.

    1993-04-30

    The development of probability of detection (POD) models for a variety of nondestructive evaluation (NDE) methods is motivated by a desire to quantify the variability introduced during the process of testing. Sources of variability involved in eddy current methods of NDE include those caused by variations in liftoff, material properties, probe canting angle, scan format, surface roughness and measurement noise. This thesis presents a comprehensive POD model for eddy current NDE. Eddy current methods of nondestructive testing are used widely in industry to inspect a variety of nonferromagnetic and ferromagnetic materials. The development of a comprehensive POD model is therefore of significant importance. The model incorporates several sources of variability characterized by a multivariate Gaussian distribution and employs finite element analysis to predict the signal distribution. The method of mixtures is then used for estimating optimal threshold values. The research demonstrates the use of a finite element model within a probabilistic framework to the spread in the measured signal for eddy current nondestructive methods. Using the signal distributions for various flaw sizes the POD curves for varying defect parameters have been computed. In contrast to experimental POD models, the cost of generating such curves is very low and complex defect shapes can be handled very easily. The results are also operator independent.

  3. Eddy current NDE performance demonstrations using simulation tools

    Energy Technology Data Exchange (ETDEWEB)

    Maurice, L. [EDF - CEIDRE, 2 rue Ampere, 93206 Saint-Denis Cedex 1 (France); Costan, V.; Guillot, E.; Thomas, P. [EDF - R and D, THEMIS, 1, avenue du General de Gaulle, 92141 Clamart (France)

    2013-01-25

    To carry out performance demonstrations of the Eddy-Current NDE processes applied on French nuclear power plants, EDF studies the possibility of using simulation tools as an alternative to measurements on steam generator tube mocks-up. This paper focuses on the strategy led by EDF to assess and use code{sub C}armel3D and Civa, on the case of Eddy-Current NDE on wears problem which may appear in the U-shape region of steam generator tubes due to the rubbing of anti-vibration bars.

  4. Dual-frequency eddy-current NDE based on high-T{sub c} rf SQUID

    Energy Technology Data Exchange (ETDEWEB)

    He, D.F.; Yoshizawa, M

    2002-12-15

    We developed a dual-frequency eddy-current NDE system based on High-T{sub c} RF superconducting quantum interference devices. This method could be used to decrease the unwanted signals caused by the variance of lift-off, to estimate the depth of crack flaw or to detect the thickness of metal structures by choosing appropriate excitation frequencies.

  5. NDE Technology Development Program for Non-Visual Volumetric Inspection Technology; Sensor Effectiveness Testing Report

    Energy Technology Data Exchange (ETDEWEB)

    Moran, Traci L.; Larche, Michael R.; Denslow, Kayte M.; Glass, Samuel W.

    2017-08-31

    The Pacific Northwest National Laboratory (PNNL) located in Richland, Washington, hosted and administered Sensor Effectiveness Testing that allowed four different participants to demonstrate the NDE volumetric inspection technologies that were previously demonstrated during the Technology Screening session. This document provides a Sensor Effectiveness Testing report for the final part of Phase I of a three-phase NDE Technology Development Program designed to identify and mature a system or set of non-visual volumetric NDE technologies for Hanford DST primary liner bottom inspection. Phase I of the program will baseline the performance of current or emerging non-visual volumetric NDE technologies for their ability to detect and characterize primary liner bottom flaws, and identify candidate technologies for adaptation and maturation for Phase II of the program.

  6. NDE Software Developed at NASA Glenn Research Center

    Science.gov (United States)

    Roth, Donald J.; Martin, Richard E.; Rauser, Richard W.; Nichols, Charles; Bonacuse, Peter J.

    2014-01-01

    NASA Glenn Research Center has developed several important Nondestructive Evaluation (NDE) related software packages for different projects in the last 10 years. Three of the software packages have been created with commercial-grade user interfaces and are available to United States entities for download on the NASA Technology Transfer and Partnership Office server (https://sr.grc.nasa.gov/). This article provides brief overviews of the software packages.

  7. IVA Ultrasonic and Eddy Current NDE for ISS Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Phased array ultrasonic testing (PAUT) instruments and array eddy current testing instruments were tested on hypervelocity impact damaged aluminum plates simulating...

  8. Composite Stress Rupture NDE Research and Development Project (Kevlar[R] and Carbon)

    Science.gov (United States)

    Saulsberry, Regor

    2010-01-01

    The objective was to develop and demonstrate nondestructive evaluation (NDE) techniques capable of assessing stress rupture related strength degradation for carbon composite pressure vessels, either in a structural health monitoring (SHM) or periodic inspection mode.

  9. Development of high-energy neutron imaging for use in NDE applications

    Energy Technology Data Exchange (ETDEWEB)

    Dietrich, F; Hall, J; Logan, C; Schmid, G

    1999-06-01

    We are currently developing a high-energy (10 - 15 MeV) neutron imaging system for use in NDE applications. Our goal is to develop an imaging system capable of detecting cubic-mm-scale voids or other structural defects in heavily-shielded low-Z materials within thick sealed objects. The system will be relatively compact (suitable for use in a small laboratory) and capable of acquiring tomographic image data sets. The design of a prototype imaging detector and multi-axis staging system will be discussed and selected results from recent imaging experiments will be presented. The development of an intense, accelerator-driven neutron source suitable for use with the imaging system will also be discussed. Keywords: neutron imaging, neutron radiography, computed tomography, non-destructive inspection, neutron sources

  10. Further development of image processing algorithms to improve detectability of defects in Sonic IR NDE

    Science.gov (United States)

    Obeidat, Omar; Yu, Qiuye; Han, Xiaoyan

    2017-02-01

    Sonic Infrared imaging (SIR) technology is a relatively new NDE technique that has received significant acceptance in the NDE community. SIR NDE is a super-fast, wide range NDE method. The technology uses short pulses of ultrasonic excitation together with infrared imaging to detect defects in the structures under inspection. Defects become visible to the IR camera when the temperature in the crack vicinity increases due to various heating mechanisms in the specimen. Defect detection is highly affected by noise levels as well as mode patterns in the image. Mode patterns result from the superposition of sonic waves interfering within the specimen during the application of sound pulse. Mode patterns can be a serious concern, especially in composite structures. Mode patterns can either mimic real defects in the specimen, or alternatively, hide defects if they overlap. In last year's QNDE, we have presented algorithms to improve defects detectability in severe noise. In this paper, we will present our development of algorithms on defect extraction targeting specifically to mode patterns in SIR images.

  11. Advanced model of eddy-current NDE inverse problem with sparse grid algorithm

    Science.gov (United States)

    Zhou, Liming; Sabbagh, Harold A.; Sabbagh, Elias H.; Murphy, R. Kim; Bernacchi, William

    2017-02-01

    In model-based inverse problem, some unknown parameters need to be estimated. These parameters are used not only to characterize the physical properties of cracks, but also to describe the position of the probes (such as lift off and angles) in the calibration. After considering the effect of the position of the probes in the inverse problem, the accuracy of the inverse result will be improved. With increasing the number of the parameters in the inverse problems, the burden of calculations will increase exponentially in the traditional full grid method. The sparse grid algorithm, which was introduced by Sergey A. Smolyak, was used in our work. With this algorithm, we obtain a powerful interpolation method that requires significantly fewer support nodes than conventional interpolation on a full grid. In this work, we combined sparse grid toolbox TASMANIAN, which is produced by Oak Ridge National Laboratory, and professional eddy-current NDE software, VIC-3D R◯, to solve a specific inverse problem. An advanced model based on our previous one is used to estimate length and depth of the crack, lift off and two angles of the position of probes. Considering the calibration process, pseudorandom noise is considered in the model and statistical behavior is discussed.

  12. Final report on the development of a disturbanceless NDE compact cooling device; Abschlussbericht zur Entwicklung einer stoerarmen maschinellen NDE-Kompaktkuehlung

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, G.

    2002-08-13

    The project comprised the following aspects: 1. Development of a disturbance-free, mechanized compact cooling system for a NDE measuring system on the basis of a commercial SL200-10 split stirling cooling system of AEG Infrarotmodule GmbH, Heilbronn; 2. Support of the development work at the HTSL/Hall magnetometer of Friedrich-Schiller University, Jena; 3. Measurements of HTSL/Hall magnetometer samples and thermal characterisation. [German] Im Rahmen dieses Vorhabens wurden die folgenden Aufgabenstellungen behandelt: 1. Entwicklung einer stoerarmen, maschinellen Kompaktkuehlung fuer ein NDE-Messsystem auf der Basis eines kommerziellen Split-Stirlingkuehlers SL200-10 der Firma AEG Infrarotmodule GmbH, Heilbronn, 2. Unterstuetzung der Entwicklungsarbeiten am HTSL/Hall-Magnetometer, die bei der Friedrich-Schiller-Universitaet in Jena durchgefuehrt wurden, 3. Messungen an HTSL/Hall-Magnetometer-Proben zu deren thermischer Charakterisierung. (orig.)

  13. NDE Process Development Specification for SRB Composite Nose Cap

    Science.gov (United States)

    Suits, M.

    1999-01-01

    The Shuttle Upgrade program is a continuing improvement process to enable the Space Shuttle to be an effective space transportation vehicle for the next few decades. The Solid Rocket Booster (SRB), as a component of that system, is currently undergoing such an improvement. Advanced materials, such as composites, have given us a chance to improve performance and to reduce weight. The SRB Composite Nose Cap (CNC) program aims to replace the current aluminum nose cap, which is coated with a Thermal Protection System and poses a possible debris hazard, with a lighter, stronger, CNC. For the next 2 years, this program will evaluate the design, material selection, properties, and verification of the CNC. This particular process specification cites the methods and techniques for verifying the integrity of such a nose cap with nondestructive evaluation.

  14. NDE Studies on CRDMs Removed From Service

    Energy Technology Data Exchange (ETDEWEB)

    Doctor, Steven R.; Cumblidge, Stephen E.; Schuster, George J.; Hockey, Ronald L.; Abrefah, John

    2005-12-31

    Studies being conducted at the Pacific Northwest National Laboratory (PNNL) in Richland, Washington are focused on assessing the effectiveness of NDE inspections of control rod drive mechanism (CRDM) nozzles and J-groove weldments. The primary objective of this work is to provide information to the United States Nuclear Regulatory Commission (US NRC) on the effectiveness of ultrasonic testing (UT) and eddy current testing (ET) as related to the in-service inspection of CRDM nozzles and J-groove weldments, and to enhance the knowledge base of primary water stress corrosion cracking (PWSCC) through destructive characterization of the CRDM assemblies. In describing two CRDM assemblies removed from service, decontaminated, and then used in a series of NDE measurements, this paper will address the following questions: 1) What did each technique detect?, 2) What did each technique miss?, 3) How accurately did each technique characterize the detected flaws? Two CRDM assemblies including the CRDM nozzle, the J-groove weld, buttering, and a portion of the ferritic head material were selected for this study. One contained suspected PWSCC, based on in-service inspection data; the other contained evidence suggesting through-wall leakage, but this was unconfirmed. The selected NDE measurements follow standard industry techniques for conducting in-service inspections of CRDM nozzles and the crown of the J-groove welds and buttering. In addition, laboratory based NDE methods will be employed to conduct inspections of the CRDM assemblies, with particular emphasis on inspecting the J-groove weld and buttering. This paper will also describe the NDE methods used and discus the NDE results. Future work will involve using the results from these NDE studies to guide the development of a destructive characterization plan to reveal the crack morphology, to be compared with NDE responses.

  15. Review of progress in quantitative NDE. [Nondestructive Evaluation (NDE)

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    This booklet is composed of abstracts from papers submitted at a meeting on quantitative NDE. A multitude of topics are discussed including analysis of composite materials, NMR uses, x-ray instruments and techniques, manufacturing uses, neural networks, eddy currents, stress measurements, magnetic materials, adhesive bonds, signal processing, NDE of mechanical structures, tomography,defect sizing, NDE of plastics and ceramics, new techniques, optical and electromagnetic techniques, and nonlinear techniques. (GHH)

  16. NDE Acoustic Microscopy Research Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The purpose is to develop advanced, more effective high-resolution micro-NDE materials characterization methods using scanning acoustic microscopy. The laboratory's...

  17. Development of a Remotely Operated NDE System for Inspection of Hanford's Double Shell Waste Tank Knuckle Regions

    Energy Technology Data Exchange (ETDEWEB)

    Pardini, Allan F.; Alzheimer, James M.; Crawford, Susan L.; Diaz, Aaron A.; Gervais, Kevin L.; Harris, Robert V.; Riechers, Douglas M.; Samuel, Todd J.; Schuster, George J.; Tucker, Joseph C.; Roberts, R. A.

    2001-09-28

    This report documents work performed at the PNNL in FY01 to support development of a Remotely Operated NDE (RONDE) system capable of inspecting the knuckle region of Hanford's DSTs. The development effort utilized commercial off-the-shelf (COTS) technology wherever possible and provided a transport and scanning device for implementing the SAFT and T-SAFT techniques.

  18. Develop algorithms to improve detectability of defects in Sonic IR imaging NDE

    Science.gov (United States)

    Obeidat, Omar; Yu, Qiuye; Han, Xiaoyan

    2016-02-01

    Sonic Infrared (IR) technology is relative new in the NDE family. It is a fast, wide area imaging method. It combines ultrasound excitation and infrared imaging while the former to apply ultrasound energy thus induce friction heating in defects and the latter to capture the IR emission from the target. This technology can detect both surface and subsurface defects such as cracks and disbands/delaminations in various materials, metal/metal alloy or composites. However, certain defects may results in only very small IR signature be buried in noise or heating patterns. In such cases, to effectively extract the defect signals becomes critical in identifying the defects. In this paper, we will present algorithms which are developed to improve the detectability of defects in Sonic IR.

  19. Development of a nonlinear ultrasonic NDE technique for detection of kissing bonds in composites

    Science.gov (United States)

    Alston, Jonathan; Croxford, Anthony; Potter, Jack; Blanloeuil, Philippe

    2017-04-01

    The development of low-cost bonded assembly of composite aerospace structures ideally requires an NDE method to detect the presence of poor quality, weak bonds or kissing bonds. Such interfaces can introduce nonlinearity as a result of contact nonlinearity where an ultrasonic wave is distorted when it interacts with the interface. In general, the nonlinear elastic behaviour of these interfaces will generate harmonics but they can be lost among the harmonics generated by other nonlinearities present in the experimental system. The technique developed in this research is a non-collinear method; this involves the interaction of two ultrasonic beams, and it allows the removal of virtually all system nonlinearity except for that produced in the region where the two beams overlap. The frequencies of the two beams and the angle between are varied during the experiment. By measuring the nonlinear mixing response as these two parameters are swept through a `fingerprint' of the nonlinear properties in the interaction region can be obtained. This fingerprint has been shown to contain information about the bulk material and the interface status. Work is ongoing to understand which features in the fingerprints reliably correlate with particular material or interface properties. To build this understanding a greatly simplified kissing bond, a compression loaded aluminium-aluminium interface, has been tested. Modelling of the nonlinear behaviour of the aluminium interface has also been conducted.

  20. Research Initiatives for Materials State Sensing (RIMSS) Task Order 0020: High Frequency Eddy Current NDE

    Science.gov (United States)

    2014-10-01

    coatings using eddy current techniques”, AIP Conference Proceedings , Vol. 1430, 2012, pp 441. 7. F. M. Smits, “Measurement of sheet resistivities with... Conference 2014: 27 October - 30 October, Charleston, SC, USA. “High-Frequency Eddy Current System for Analyzing Wet Conductive Coatings during...Processing”. 3. QNDE 2014 (ORAL PRESENTATION), 41st Annual Review of Progress in Quantitative Nondestructive Evaluation: Conference Boise Centre

  1. Nondestructive Evaluation (NDE) research progress in 1988: Proceedings from the ninth annual EPRI NDE information meeting

    Energy Technology Data Exchange (ETDEWEB)

    Avioli, M.J. Jr.; Dau, G.J.; Liu, S.N.; Stein, J.; Welty, C.S.

    1989-05-01

    The increasing cost of equipment for power generating plants and the potential increases in productivity and safety analysis through rapidly developing Nondestructive Evaluation (NDE) technology led EPRI to initiate a Nondestructive Evaluation Program in 1974. To date, the major focus has been on light water reactor inspection problems; however, increased application to other systems is now underway. This report presents a comprehensive review of the EPRI effort in the NDE area. Most of the report consists of contractor-supplied progress reports on each current project. An organizational plan of the program is presented in overview. In addition, organization from several viewpoints is presented, e.g., in-service inspection operators, R and D personnel, and utility representatives. As the tenth in a planned series of annual progress reports of EPRI-funded NDE activities, this report also serves as the proceedings of the Ninth Annual EPRI NDE Information Meeting held in Charlotte, North Carolina, on November 15--16, 1988. It summarizes significant progress made since the previous EPRI Special Report NP-5490-SR was issued in June 1988. Section 1 contains information about the program organization, and the sections that follow contain contractor-supplied progress reports on each current project. The progress reports are grouped by plant components -- pipe, pressure vessel, and steam generator and boiler tubes. In addition, Part 5 is devoted to discussions of technology transfer.

  2. Positioning challenges in reconfigurable semi-autonomous robotic NDE inspection

    Science.gov (United States)

    Pierce, S. Gareth; Dobie, Gordon; Summan, Rahul; Mackenzie, Liam; Hensman, James; Worden, Keith; Hayward, Gordon

    2010-03-01

    This paper describes work conducted into mobile, wireless, semi-autonomous NDE inspection robots developed at The University of Strathclyde as part of the UK Research Centre for Non Destructive Evaluation (RCNDE). The inspection vehicles can incorporate a number of different NDE payloads including ultrasonic, eddy current, visual and magnetic based payloads, and have been developed to try and improve NDE inspection techniques in challenging inspection areas (for example oil, gas, and nuclear structures). A significant research challenge remains in the accurate positioning and guidance of such vehicles for real inspection tasks. Employing both relative and absolute position measurements, we discuss a number of approaches to position estimation including Kalman and particle filtering. Using probabilistic approaches enables a common mathematical framework to be employed for both positioning and data fusion from different NDE sensors. In this fashion the uncertainties in both position and defect identification and classification can be dealt with using a consistent approach. A number of practical constraints and considerations to different precision positioning techniques are discussed, along with NDE applications and the potential for improved inspection capabilities by utilising the inherent reconfigurable capabilities of the inspection vehicles.

  3. CIVA workstation for NDE: mixing of NDE techniques and modeling

    Energy Technology Data Exchange (ETDEWEB)

    Benoist, P.; Besnard, R. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. des Procedes et Systemes Avances; Bayon, G. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. des Reacteurs Experimentaux; Boutaine, J.L. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. des Applications et de la Metrologie des Rayonnements Ionisants

    1994-12-31

    In order to compare the capabilities of different NDE techniques, or to use complementary inspection methods, the same components are examined with different procedures. It is then very useful to have a single evaluation tool allowing direct comparison of the methods: CIVA is an open system for processing NDE data; it is adapted to a standard work station (UNIX, C, MOTIF) and can read different supports on which the digitized data are stored. It includes a large library of signal and image processing methods accessible and adapted to NDE data (filtering, deconvolution, 2D and 3D spatial correlations...). Different CIVA application examples are described: brazing inspection (neutronography, ultrasonic), tube inspection (eddy current, ultrasonic), aluminium welds examination (UT and radiography). Modelling and experimental results are compared. 16 fig., 7 ref.

  4. Steam generator tubing NDE performance

    Energy Technology Data Exchange (ETDEWEB)

    Henry, G. [Electric Power Research Institute, Charlotte, NC (United States); Welty, C.S. Jr. [Electric Power Research Institute, Palo Alto, CA (United States)

    1997-02-01

    Steam generator (SG) non-destructive examination (NDE) is a fundamental element in the broader SG in-service inspection (ISI) process, a cornerstone in the management of PWR steam generators. Based on objective performance measures (tube leak forced outages and SG-related capacity factor loss), ISI performance has shown a continually improving trend over the years. Performance of the NDE element is a function of the fundamental capability of the technique, and the ability of the analysis portion of the process in field implementation of the technique. The technology continues to improve in several areas, e.g. system sensitivity, data collection rates, probe/coil design, and data analysis software. With these improvements comes the attendant requirement for qualification of the technique on the damage form(s) to which it will be applied, and for training and qualification of the data analysis element of the ISI process on the field implementation of the technique. The introduction of data transfer via fiber optic line allows for remote data acquisition and analysis, thus improving the efficiency of analysis for a limited pool of data analysts. This paper provides an overview of the current status of SG NDE, and identifies several important issues to be addressed.

  5. Nondestructive evaluation research progress in 1989: Proceedings from the tenth annual EPRI NDE information meeting

    Energy Technology Data Exchange (ETDEWEB)

    Avioli, M.J. Jr.; Behravesh, M.M.; Gehl, S.M.; Liu, S.N.; Stein, J.; Welty, C.S. (Electric Power Research Inst., Palo Alto, CA (USA))

    1990-06-01

    The increasing cost of equipment for power generating plants and the potential increases in productivity and safety available through rapidity developing nondestructive evaluation (NDE) technology led EPRI to initiate a Nondestructive Evaluation Program in 1974. To date, the major focus has been on light water reactor (LWR) inspection problems; however, increased application to other systems is now under way. This report presents a comprehensive review of the EPRI effort in the NDE area. Most of the report consists of contractor-supplied progress reports on each current project. An organizational plan of the program is presented in overview. In addition, organization from several viewpoints is presented, e.g., in-service inspection operators, R D personnel, and utility representatives. As the eleventh in a planned series of annual progress reports of EPRI-funded NDE activities, this report also serves as the proceedings of the Tenth Annual EPRI NDE Information Meeting held in Palo Alto, California, on November 14-15, 1989. It summarizes significant progress made since the previous EPRI Special Report NP-6075-SR was issued in May 1989. Section 1 contains information about the program organization, and the sections that follow contain contractor-supplied progress reports on each current project. The progress reports are grouped by plant components -- pipe and nozzle, pressure vessel, and boilers and steam generators. In addition, Part 5 is devoted to discussions of technology transfer. The individual papers have been cataloged separately.

  6. Reliably Detectable Flaw Size for NDE Methods that Use Calibration

    Science.gov (United States)

    Koshti, Ajay M.

    2017-01-01

    Probability of detection (POD) analysis is used in assessing reliably detectable flaw size in nondestructive evaluation (NDE). MIL-HDBK-1823 and associated mh1823 POD software gives most common methods of POD analysis. In this paper, POD analysis is applied to an NDE method, such as eddy current testing, where calibration is used. NDE calibration standards have known size artificial flaws such as electro-discharge machined (EDM) notches and flat bottom hole (FBH) reflectors which are used to set instrument sensitivity for detection of real flaws. Real flaws such as cracks and crack-like flaws are desired to be detected using these NDE methods. A reliably detectable crack size is required for safe life analysis of fracture critical parts. Therefore, it is important to correlate signal responses from real flaws with signal responses form artificial flaws used in calibration process to determine reliably detectable flaw size.

  7. Ultrasonic wavefield imaging: Research tool or emerging NDE method?

    Science.gov (United States)

    Michaels, Jennifer E.

    2017-02-01

    Ultrasonic wavefield imaging refers to acquiring full waveform data over a region of interest for waves generated by a stationary source. Although various implementations of wavefield imaging have existed for many years, the widespread availability of laser Doppler vibrometers that can acquire signals in the high kHz and low MHz range has resulted in a rapid expansion of fundamental research utilizing full wavefield data. In addition, inspection methods based upon wavefield imaging have been proposed for standalone nondestructive evaluation (NDE) with most of these methods coming from the structural health monitoring (SHM) community and based upon guided waves. If transducers are already embedded in or mounted on the structure as part of an SHM system, then a wavefield-based inspection can potentially take place with very little required disassembly. A frequently-proposed paradigm for wavefield NDE is its application as a follow-up inspection method using embedded SHM transducers as guided wave sources if the in situ SHM system generates an alarm. Discussed here is the broad role of wavefield imaging as it relates to ultrasonic NDE, both as a research tool and as an emerging NDE method. Examples of current research are presented based upon both guided and bulk wavefield imaging in metals and composites, drawing primarily from the author's work. Progress towards wavefield NDE is discussed in the context of defect detection and characterization capabilities, scan times, data quality, and required data analysis. Recent research efforts are summarized that can potentially enable wavefield NDE.

  8. On-Line NDE for Advanced Reactor Designs

    Science.gov (United States)

    Nakagawa, N.; Inanc, F.; Thompson, R. B.; Junker, W. R.; Ruddy, F. H.; Beatty, J. M.; Arlia, N. G.

    2003-03-01

    This expository paper introduces the concept of on-line sensor methodologies for monitoring the integrity of components in next generation power systems, and explains general benefits of the approach, while describing early conceptual developments of suitable NDE methodologies. The paper first explains the philosophy behind this approach (i.e. the design-for-inspectability concept). Specifically, we describe where and how decades of accumulated knowledge and experience in nuclear power system maintenance are utilized in Generation IV power system designs, as the designs are being actively developed, in order to advance their safety and economy. Second, we explain that Generation IV reactor design features call for the replacement of the current outage-based maintenance by on-line inspection and monitoring. Third, the model-based approach toward design and performance optimization of on-line sensor systems, using electromagnetic, ultrasonic, and radiation detectors, will be explained. Fourth, general types of NDE inspections that are considered amenable to on-line health monitoring will be listed. Fifth, we will describe specific modeling developments to be used for radiography, EMAT UT, and EC detector design studies.

  9. Model assisted qualification of NDE techniques

    Science.gov (United States)

    Ballisat, Alexander; Wilcox, Paul; Smith, Robert; Hallam, David

    2017-02-01

    The costly and time consuming nature of empirical trials typically performed for NDE technique qualification is a major barrier to the introduction of NDE techniques into service. The use of computational models has been proposed as a method by which the process of qualification can be accelerated. However, given the number of possible parameters present in an inspection, the number of combinations of parameter values scales to a power law and running simulations at all of these points rapidly becomes infeasible. Given that many NDE inspections result in a single valued scalar quantity, such as a phase or amplitude, using suitable sampling and interpolation methods significantly reduces the number of simulations that have to be performed. This paper presents initial results of applying Latin Hypercube Designs and M ultivariate Adaptive Regression Splines to the inspection of a fastener hole using an oblique ultrasonic shear wave inspection. It is demonstrated that an accurate mapping of the response of the inspection for the variations considered can be achieved by sampling only a small percentage of the parameter space of variations and that the required percentage decreases as the number of parameters and the number of possible sample points increases. It is then shown how the outcome of this process can be used to assess the reliability of the inspection through commonly used metrics such as probability of detection, thereby providing an alternative methodology to the current practice of performing empirical probability of detection trials.

  10. Quantitative NDE of Composite Structures at NASA

    Science.gov (United States)

    Cramer, K. Elliott; Leckey, Cara A. C.; Howell, Patricia A.; Johnston, Patrick H.; Burke, Eric R.; Zalameda, Joseph N.; Winfree, William P.; Seebo, Jeffery P.

    2015-01-01

    The use of composite materials continues to increase in the aerospace community due to the potential benefits of reduced weight, increased strength, and manufacturability. Ongoing work at NASA involves the use of the large-scale composite structures for spacecraft (payload shrouds, cryotanks, crew modules, etc). NASA is also working to enable the use and certification of composites in aircraft structures through the Advanced Composites Project (ACP). The rapid, in situ characterization of a wide range of the composite materials and structures has become a critical concern for the industry. In many applications it is necessary to monitor changes in these materials over a long time. The quantitative characterization of composite defects such as fiber waviness, reduced bond strength, delamination damage, and microcracking are of particular interest. The research approaches of NASA's Nondestructive Evaluation Sciences Branch include investigation of conventional, guided wave, and phase sensitive ultrasonic methods, infrared thermography and x-ray computed tomography techniques. The use of simulation tools for optimizing and developing these methods is also an active area of research. This paper will focus on current research activities related to large area NDE for rapidly characterizing aerospace composites.

  11. 40-in. OMS Kevlar(Registered Trademark) COPV S/N 007 Stress Rupture Test NDE

    Science.gov (United States)

    Saulsberry, Regor; Greene, Nate; Forth, Scott; Leifeste, Mark; Gallus, Tim; Yoder, Tommy; Keddy, Chris; Mandaras, Eric; Wincheski, Buzz; Williams, Philip; Russell, Richard; Eldridge, Jeff

    2010-01-01

    The presentation examines pretest nondestructive evaluation (NDE), including external/internal visual inspection, raman spectroscopy, laser shearography, and laser profilometry; real-time NDE including eddy current, acoustic emission (AE), and real-time portable raman spectroscopy; and AE application to carbon/epoxy composite overwrapped pressure vessels.

  12. NDE to Manage Atmospheric SCC in Canisters for Dry Storage of Spent Fuel: An Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ryan M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pardini, Allan F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Cuta, Judith M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Adkins, Harold E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Casella, Andrew M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Qiao, Hong [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Larche, Michael R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Diaz, Aaron A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Doctor, Steven R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-09-01

    This report documents efforts to assess representative horizontal (Transuclear NUHOMS®) and vertical (Holtec HI-STORM) storage systems for the implementation of non-destructive examination (NDE) methods or techniques to manage atmospheric stress corrosion cracking (SCC) in canisters for dry storage of used nuclear fuel. The assessment is conducted by assessing accessibility and deployment, environmental compatibility, and applicability of NDE methods. A recommendation of this assessment is to focus on bulk ultrasonic and eddy current techniques for direct canister monitoring of atmospheric SCC. This assessment also highlights canister regions that may be most vulnerable to atmospheric SCC to guide the use of bulk ultrasonic and eddy current examinations. An assessment of accessibility also identifies canister regions that are easiest and more difficult to access through the ventilation paths of the concrete shielding modules. A conceivable sampling strategy for canister inspections is to sample only the easiest to access portions of vulnerable regions. There are aspects to performing an NDE inspection of dry canister storage system (DCSS) canisters for atmospheric SCC that have not been addressed in previous performance studies. These aspects provide the basis for recommendations of future efforts to determine the capability and performance of eddy current and bulk ultrasonic examinations for atmospheric SCC in DCSS canisters. Finally, other important areas of investigation are identified including the development of instrumented surveillance specimens to identify when conditions are conducive for atmospheric SCC, characterization of atmospheric SCC morphology, and an assessment of air flow patterns over canister surfaces and their influence on chloride deposition.

  13. On-orbit NDE: A novel approach to tube weld inspection

    Science.gov (United States)

    Michaels, Kerry; Hughes, Greg

    1994-01-01

    The challenge of fabrication and repair of structures in space must be met if we are to utilize and maintain long-duration space facilities. Welding techniques have been demonstrated to provide the most reliable means to accomplish this task. Over the past few years, methods have been developed to perform orbital tube welding employing space-based welding technology pioneered by the former Soviet Union. Welding can result in the formation of defects, which threaten the structural integrity of the welded joint. Implementation of welding on-orbit, therefore, must also include methods to evaluate the quality and integrity of the welded joints. To achieve this goal, the development of an on-orbit tube weld inspection system, utilizing alternating current field measurement (ACFM) technology, has been under taken. This paper describes the development of the ACFM on-orbit tube weld inspection tool. Topics discussed include: requirements for on-orbit NDE, basic theory of ACFM, its advantages over other NDE methods for on-orbit applications, and the ACFM NDE system design. System operation and trial inspection results are also discussed. Future work with this technology is also considered.

  14. NDE applications in microelectronic industries

    Science.gov (United States)

    Meyendorf, N.; Oppermann, M.; Krueger, P.; Roellig, M.; Wolter, K. J.

    2016-04-01

    New concepts in assembly technology boost our daily life in an unknown way. High end semiconductor industry today deals with functional structures down to a few nanometers. ITRS roadmap predicts an ongoing decrease of the "DRAM half pitch" over the next decade. Packaging of course is not intended to realize pitches at the nanometer scale, but has to face the challenges of integrating such semiconductor devices with smallest pitch and high pin counts into systems. Advanced techniques of nondestructive evaluation (NDE) with resolutions in volume better than 1 micrometer vixen size are urgently needed for the safety and reliability of electronic systems, especially those that are used in long living applications. The development speed of integrated circuits is still very high and is not expected to decrease in the next future. The integration density of microelectronic devices is increasing, the dimensions become smaller and the number of I/O's is getting higher. The development of new types of packages must be done with respect to reliability issues. Potential damage sources must be identified and finally avoided in the new packages. In power electronics production the condition monitoring receives a lot of interest to avoid electrical shortcuts, dead solder joints and interface cracking. It is also desired to detect and characterize very small defects like transportation phenomenon or Kirkendall voids. For this purpose, imaging technologies with resolutions in the sub-micron range are required.

  15. Current Developments in Cognitive Linguistics

    Institute of Scientific and Technical Information of China (English)

    Dirk Geeraerts

    2008-01-01

    After 30 years of theoretical development, we need to address the question whether the internal evolution of Cognitive Linguistics can be synthesized: what are the fundamental underlying trends in Cognitive Linguistics, and how do they shape the current developments within Cognitive Linguistics? This paper argues that Cognitive Linguistics is essentially characterized by a gradual recontextualization of the grammar. First, the development of 20th century grammar is characterized by a succession of a decontextualizing and a recontextualizing movement. Second, the various stages in the development of Cognitive Linguistics involve the gradual recovery of the various types of context that were discarded by generative grammar. These involve the experiential and embodied context of meaning in natural Language, the pragmatic context of actual language usage, and the social and cultural context of language as a shared code.

  16. Sinoprobe Datacenter Development: Current Status

    Science.gov (United States)

    Guan, Y.; Dong, S.; Chen, Z.; Chen, G.; Cheng, M.

    2011-12-01

    The project of the Sinoprobe datacenter development is to build new IT infrastructures needed to store, visualize and manage all the data acquired by SinoProbe program.The SinoProbe data center is designed using service-oriented architecture (SOA) principles. More specifically, service component architecture (SCA) is used to implement sinoprobe data services. It also uses various advanced technologies such as Java/JEE for the platform, PostgresSQL/PostGIS for the data storage, ApacheDS for LDAP, CoachDB for the medadata storage, GeoServer for the GIS services, ExtJs and OpenLayer for the Ajax framework, and Apache Shiro for the security framework. Through the integration and development of various technologies used, the major services of the datacenter system are implemented including the security infrastructure services (user authentication and authorization), metadata services, data warehouse stores, data services, GIS services, and web portal. There are also visualization components including the development of a virtual globe to replace the currently used Google Earth. This poster presents the current status of the SinoProbe data center development, and the detailed discussion of the system.

  17. Development of a 3D Electromagnetic Model for Eddy Current Tubing Inspection: Application to Steam Generator Tubing

    Science.gov (United States)

    Pichenot, G.; Prémel, D.; Sollier, T.; Maillot, V.

    2004-02-01

    In nuclear plants, the inspection of heat exchanger tubes is usually carried out by using eddy current nondestructive testing. A numerical model, based on a volume integral approach using the Green's dyadic formalism, has been developed, with support from the French Institute for Radiological Protection and Nuclear Safety, to predict the response of an eddy current bobbin coil to 3D flaws located in the tube's wall. With an aim of integrating this model into the NDE multi techniques platform CIVA, it has been validated with experimental data for 2D and 3D flaws.

  18. NASA NDE Applications for Mobile MEMS Devices and Sensors

    Science.gov (United States)

    Wilson, William C.; Atkinson, Gary M.; Barclay, R. O.

    2008-01-01

    NASA would like new devices and sensors for performing nondestructive evaluation (NDE) of aerospace vehicles. These devices must be small in size/volume, mass, and power consumption. The devices must be autonomous and mobile so they can access the internal structures of aircraft and spacecraft and adequately monitor the structural health of these craft. The platforms must be mobile in order to transport NDE sensors for evaluating structural integrity and determining whether further investigations will be required. Microelectromechanical systems (MEMS) technology is crucial to the development of the mobile platforms and sensor systems. This paper presents NASA s needs for micro mobile platforms and MEMS sensors that will enable NDE to be performed on aerospace vehicles.

  19. Composite Flywheels Assessed Analytically by NDE and FEA

    Science.gov (United States)

    Abdul-Aziz, Ali; Baaklini, George Y.

    2000-01-01

    As an alternative to expensive and short-lived lead-acid batteries, composite flywheels are being developed to provide an uninterruptible power supply for advanced aerospace and industrial applications. Flywheels can help prevent irregularities in voltage caused by power spikes, sags, surges, burnout, and blackouts. Other applications include load-leveling systems for wind and solar power facilities, where energy output fluctuates with weather. Advanced composite materials are being considered for these components because they are significantly lighter than typical metallic alloys and have high specific strength and stiffness. However, much more research is needed before these materials can be fully utilized, because there is insufficient data concerning their fatigue characteristics and nonlinear behavior, especially at elevated temperatures. Moreover, these advanced types of structural composites pose greater challenges for nondestructive evaluation (NDE) techniques than are encountered with typical monolithic engineering metals. This is particularly true for ceramic polymer and metal matrix composites, where structural properties are tailored during the processing stages. Current efforts involving the NDE group at the NASA Glenn Research Center at Lewis Field are focused on evaluating many important structural components, including the flywheel system. Glenn's in-house analytical and experimental capabilities are being applied to analyze data produced by computed tomography (CT) scans to help assess the damage and defects of high-temperature structural composite materials. Finite element analysis (FEA) has been used extensively to model the effects of static and dynamic loading on aerospace propulsion components. This technique allows the use of complicated loading schemes by breaking the complex part geometry into many smaller, geometrically simple elements.

  20. Rocket center Peenemünde — Personal memories

    Science.gov (United States)

    Dannenberg, Konrad; Stuhlinger, Ernst

    Von Braun built his first rockets as a young teenager. At 14, he started making plans for rockets for human travel to the Moon and Mars. The German Army began a rocket program in 1929. Two years later, Colonel (later General) Becker contacted von Braun who experimented with rockets in Berlin, gave him a contract in 1932, and, jointly with the Air Force, in 1936 built the rocket center Peenemünde where von Braun and his team developed the A-4 (V-2) rocket under Army auspices, while the Air Force developed the V-1 (buzz bomb), wire-guided bombs, and rocket planes. Albert Speer, impressed by the work of the rocketeers, allowed a modest growth of the Peenemünde project; this brought Dannenberg to the von Braun team in 1940. Hitler did not believe in rockets; he ignored the A-4 project until 1942 when he began to support it, expecting that it could turn the fortunes of war for him. He drastically increased the Peenemünde work force and allowed the transfer of soldiers from the front to Peenemünde; that was when Stuhlinger, in 1943, came to Peenemünde as a Pfc.-Ph.D. Later that year, Himmler wrenched the authority over A-4 production out of the Army's hands, put it under his command, and forced production of the immature rocket at Mittelwerk, and its military deployment against targets in France, Belgium, and England. Throughout the development of the A-4 rocket, von Braun was the undisputed leader of the project. Although still immature by the end of the war, the A-4 had proceeded to a status which made it the first successful long-range precision rocket, the prototype for a large number of military rockets built by numerous nations after the war, and for space rockets that launched satellites and traveled to the Moon and the planets.

  1. Platform for Post-Processing Waveform-Based NDE

    Science.gov (United States)

    Roth, Don J.

    2010-01-01

    Signal- and image-processing methods are commonly needed to extract information from the waves, improve resolution of, and highlight defects in an image. Since some similarity exists for all waveform-based nondestructive evaluation (NDE) methods, it would seem that a common software platform containing multiple signal- and image-processing techniques to process the waveforms and images makes sense where multiple techniques, scientists, engineers, and organizations are involved. NDE Wave & Image Processor Version 2.0 software provides a single, integrated signal- and image-processing and analysis environment for total NDE data processing and analysis. It brings some of the most useful algorithms developed for NDE over the past 20 years into a commercial-grade product. The software can import signal/spectroscopic data, image data, and image series data. This software offers the user hundreds of basic and advanced signal- and image-processing capabilities including esoteric 1D and 2D wavelet-based de-noising, de-trending, and filtering. Batch processing is included for signal- and image-processing capability so that an optimized sequence of processing operations can be applied to entire folders of signals, spectra, and images. Additionally, an extensive interactive model-based curve-fitting facility has been included to allow fitting of spectroscopy data such as from Raman spectroscopy. An extensive joint-time frequency module is included for analysis of non-stationary or transient data such as that from acoustic emission, vibration, or earthquake data.

  2. [Nondestructive Evaluation (NDE) Capabilities

    Science.gov (United States)

    Born, Martin

    2010-01-01

    These poster boards display the United Space Alliance's (USA) systems and equipment used for Nondestructive Evaluation. These include: (1) the Robotic Inspection Facility, (2) CAT-Scan and Laminography, (3) Laser Surface Profilometry, (4) Remote Eddy Current, (5) Ultrasonic Phased Array, (7) Infrared Flash Thermography, and (8) Backscatter X-Ray (BSX)

  3. Spatially Coherent Optical Velocimeter Array for Rapid Guided-wave NDE Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The pace and progress of new sensor technology development continues to lag far behind the broad ranging potential offered by guided wave NDE. In response to NASA...

  4. Current biotechnological developments in Belgium.

    Science.gov (United States)

    Masschelein, C A; Callegari, J P; Laurent, M; Simon, J P; Taeymans, D

    1989-01-01

    In recent years, actions have been undertaken by the Belgian government to promote process innovation and technical diversification. Research programs are initiated and coordinated by the study committee for biotechnology setup within the Institute for Scientific Research in Industry and Agriculture (IRSIA). As a result of this action, the main areas where biotechnological processes are developed or commercially exploited include plant genetics, protein engineering, hybridoma technology, biopesticides, production by genetic engineering of vaccines and drugs, monoclonal detection of human and animal deseases, process reactors for aerobic and anaerobic wastewater treatment, and genetic modification of yeast and bacteria as a base for biomass and energy. Development research also includes new fermentation technologies principally based on immobilization of microorganisms, reactor design, and optimization of unit operations involved in downstream processing. Food, pharmaceutical, and chemical industries are involved in genetic engineering and biotechnology and each of these sectors is overviewed in this paper.

  5. Current developments in canine genetics.

    Science.gov (United States)

    Marschall, Yvonne; Distl, Ottmar

    2010-01-01

    In recent years, canine genetics had made huge progress. In 1999 the first complete karyotype and ideogram of the dog was published. Several linkage and RH maps followed. Using these maps, sets of microsatellite markers for whole genome scans were compiled. In 2003 the sequencing of the DNA of a female Boxer began. Now the second version of the dog genome assembly has been put online, and recently, a microchip SNP array became available. Parallel to these developments, some causal mutations for different traits have been identified. Most of the identified mutations were responsible for monogenic canine hereditary diseases. With the tools available now, it is possible to use the advantages of the population structure of the various dog breeds to unravel complex genetic traits. Furthermore, the dog is a suitable model for the research of a large number of human hereditary diseases and particularly for cancer genetics, heart and neurodegenerative diseases. There are some examples where it was possible to benefit from the knowledge of canine genetics for human research. The search for quantitative trait loci (QTL), the testing of candidate genes and genome-wide association studies can now be performed in dogs. QTL for skeletal size variations and for canine hip dysplasia have been already identified and for these complex traits the responsible genes and their possible interactions can now be identified.

  6. Stable High-T {sub c} rf SQUID NDE system operating in noisy environment

    Energy Technology Data Exchange (ETDEWEB)

    He, D.F. [Superconducting Materials Center, National Institute for Materials Science, Sengen 1-2-1, Tsukuba, Ibaraki 305-0047 (Japan)]. E-mail: he.dongfeng@nims.go.jp; Yoshizawa, M. [Iwate University, Ueda 4-3-5, Morioka 020-8551 (Japan); Itozaki, H. [Superconducting Materials Center, National Institute for Materials Science, Sengen 1-2-1, Tsukuba, Ibaraki 305-0047 (Japan)

    2006-04-15

    A high-T {sub c} rf SQUID NDE system was developed for stable, long time operation in a noisy environment. To reduce the influence of high frequency electromagnetic interference (EMI), a carefully designed metal shielding made of 0.1 mm thick metal foil was used. With the metal shielding, the SQUID could still operate well when a cellular phone was used nearby although the cellular phone could produce very strong EMI noises. To reduce the influence of the line interference or low frequency noises, a compensation method was used in the SQUID-based NDE system. With the compensation, the low frequency and the line interference could be reduced well. Using this SQUID-based NDE system, we successfully performed the NDE measurements in a noisy environment.

  7. NDE for the ARES I Upper Stage Common Bulkhead

    Science.gov (United States)

    Walker, James

    2008-01-01

    The current design of the ARES 1 Upper Stage uses a common bulkhead to separate the liquid hydrogen and liquid oxygen tanks. The bulkhead consists of aluminum face sheets bonded to a Phenolic honeycomb core. The face sheets, or domes, are friction stir welded to Y-rings that connect the bulkhead to the barrel sections of the liquid hydrogen and liquid oxygen tanks. Load between the Y-rings is carried by an externally attached bolting ring. The development of nondestructive evaluation methods for the ARES I Upper Stage Common Bulkhead are outlined in this presentation. Methods for inspecting the various components of the bulkhead are covered focusing in on the dome skins, core-to-dome bond lines and friction stir welds as well as structural details like the fastener holes. Thermography, shearography and ultrasonic methods are discussed for the bond lines. Eddy current methods are discussed for the fastener holes and dome skins. A combination of phased array ultrasound, liquid penetrant and radiography are to being investigated for use on the friction stir welds. Keywords: Composite materials, NDE, Cryogenic structures

  8. Aquantis Ocean Current Turbine Development Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Fleming, Alex J.

    2014-08-23

    The Aquantis® Current Plane (“C-Plane”) technology developed by Dehlsen Associates, LLC (DA) and Aquantis, Inc. is an ocean current turbine designed to extract kinetic energy from ocean currents. The technology is capable of achieving competitively priced base-load, continuous, and reliable power generation from a source of renewable energy not before possible in this scale or form.

  9. Robotic Inspection System for Non-Destructive Evaluation (nde) of Pipes

    Science.gov (United States)

    Mackenzie, L. D.; Pierce, S. G.; Hayward, G.

    2009-03-01

    The demand for remote inspection of pipework in the processing cells of nuclear plant provides significant challenges of access, navigation, inspection technique and data communication. Such processing cells typically contain several kilometres of densely packed pipework whose actual physical layout may be poorly documented. Access to these pipes is typically afforded through the radiation shield via a small removable concrete plug which may be several meters from the actual inspection site, thus considerably complicating practical inspection. The current research focuses on the robotic deployment of multiple NDE payloads for weld inspection along non-ferritic steel pipework (thus precluding use of magnetic traction options). A fully wireless robotic inspection platform has been developed that is capable of travelling along the outside of a pipe at any orientation, while avoiding obstacles such as pipe hangers and delivering a variety of NDE payloads. An eddy current array system provides rapid imaging capabilities for surface breaking defects while an on-board camera, in addition to assisting with navigation tasks, also allows real time image processing to identify potential defects. All sensor data can be processed by the embedded microcontroller or transmitted wirelessly back to the point of access for post-processing analysis.

  10. Automated NDE Flaw Mapping System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA's Aircraft Aging and Durability Project (AADP) aims to ensure the safety of both commercial and military aviation aircraft. Non-destructive evaluation (NDE)...

  11. Automated NDE Flaw Mapping System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The prevailing approach to non-destructive evaluation (NDE) of aircraft components is to set an inspection schedule based on what is generally known about the...

  12. NDE for Ablative Thermal Protection Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This program addresses the need for non-destructive evaluation (NDE) methods for quality assessment and defect evaluation of thermal protection systems (TPS),...

  13. NDE for Ablative Thermal Protection Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This program addresses the need for non-destructive evaluation (NDE) methods for quality assessment and defect evaluation of thermal protection systems (TPS). Novel...

  14. Through the looking glass: The future for NDE?

    Science.gov (United States)

    Bond, Leonard J.

    2014-02-01

    Nondestructive testing (NDT) is a mature industry, with global equipment sales fast moving towards 2B. per year. The use of conventional NDT will grow in developing countries and in developed countries the challenges will include those associated with maintaining aging infrastructure. For some systems the future will move to structural health monitoring (SHM) and for others into integration of online measurements in manufacturing. Nondestructive Evaluation (NDE) is a multi-disciplinary area of endeavor that has its origins in materials science and NDT. It seeks to provide an adequate science base for NDT to become a quantitative science. It was seen to be necessary to better detect, size and type defects, improve the reliability of inspection, and probability of detection (POD). There is particular interest in estimating the potential defects could have on performance or potential for loss of structural integrity, under various loading or stressor conditions, and ultimately implement risk-based reliability assessments. NDE must be seen more as a part of the wide field of engineering, as an interdisciplinary endeavor, that brings together the expertise of materials science and metrology, together with the underlying physics for inspection methods, as well as statistics, computers, robotics and software. The adoption of advanced manufacturing, will require new metrology tools and methods to provide data for assessing new materials including powder metals, as used in additive manufacturing, and various composites. The lessons from the past proceedings of this conference series include that the problems faced today are harder than was expected during the first decade of quantitative NDE research. Even with new types of transducers and much improved A/D and powerful computers new approaches and more basic measurement physics being understood, new insights are needed to provide the data needed to solve many real-world NDE problems, to understand and measure early

  15. NDE for Characterizing Oxidation Damage in Reinforced Carbon-Carbon

    Science.gov (United States)

    Roth, Don J.; Rauser, Richard W.; Jacobson, nathan S.; Wincheski, Russell A.; Walker, James L.; Cosgriff, Laura A.

    2009-01-01

    In this study, coated reinforced carbon-carbon (RCC) samples of similar structure and composition as that from the NASA space shuttle orbiter s thermal protection system were fabricated with slots in their coating simulating craze cracks. These specimens were used to study oxidation damage detection and characterization using NDE methods. These specimens were heat treated in air at 1143 and 1200 C to create cavities in the carbon substrate underneath the coating as oxygen reacted with the carbon and resulted in its consumption. The cavities varied in diameter from approximately 1 to 3 mm. Single-sided NDE methods were used since they might be practical for on-wing inspection, while x-ray micro-computed tomography (CT) was used to measure cavity sizes in order to validate oxidation models under development for carbon-carbon materials. An RCC sample having a naturally-cracked coating and subsequent oxidation damage was also studied with x-ray micro-CT. This effort is a follow-on study to one that characterized NDE methods for assessing oxidation damage in an RCC sample with drilled holes in the coating. The results of that study are briefly reviewed in this article as well. Additionally, a short discussion on the future role of simulation to aid in these studies is provided.

  16. Platform for Postprocessing Waveform-Based NDE

    Science.gov (United States)

    Roth, Don

    2008-01-01

    Taking advantage of the similarities that exist among all waveform-based non-destructive evaluation (NDE) methods, a common software platform has been developed containing multiple- signal and image-processing techniques for waveforms and images. The NASA NDE Signal and Image Processing software has been developed using the latest versions of LabVIEW, and its associated Advanced Signal Processing and Vision Toolkits. The software is useable on a PC with Windows XP and Windows Vista. The software has been designed with a commercial grade interface in which two main windows, Waveform Window and Image Window, are displayed if the user chooses a waveform file to display. Within these two main windows, most actions are chosen through logically conceived run-time menus. The Waveform Window has plots for both the raw time-domain waves and their frequency- domain transformations (fast Fourier transform and power spectral density). The Image Window shows the C-scan image formed from information of the time-domain waveform (such as peak amplitude) or its frequency-domain transformation at each scan location. The user also has the ability to open an image, or series of images, or a simple set of X-Y paired data set in text format. Each of the Waveform and Image Windows contains menus from which to perform many user actions. An option exists to use raw waves obtained directly from scan, or waves after deconvolution if system wave response is provided. Two types of deconvolution, time-based subtraction or inverse-filter, can be performed to arrive at a deconvolved wave set. Additionally, the menu on the Waveform Window allows preprocessing of waveforms prior to image formation, scaling and display of waveforms, formation of different types of images (including non-standard types such as velocity), gating of portions of waves prior to image formation, and several other miscellaneous and specialized operations. The menu available on the Image Window allows many further image

  17. Development of high current electron beam generator

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byeong Cheol; Lee, Jong Min; Kim, Sun Kook [and others

    1997-05-01

    A high-current electron beam generator has been developed. The energy and the average current of the electron beam are 2 MeV and 50 mA, respectively. The electron beam generator is composed of an electron gun, RF acceleration cavities, a 260-kW RF generator, electron beam optics components, and control system, etc. The electron beam generator will be used for the development of a millimeter-wave free-electron laser and a high average power infrared free-electron laser. The machine will also be used as a user facility in nuclear industry, environment industry, semiconductor industry, chemical industry, etc. (author). 15 tabs., 85 figs.

  18. Nondestructive Examination (NDE) Detection and Characterization of Degradation Precursors, Technical Progress Report for FY 2012

    Energy Technology Data Exchange (ETDEWEB)

    Ramuhalli, P.; Meyer, R.M.; Fricke, J.M.; Prowant, M.S.; Coble, J.B.; Griffin, J.W.; Pitman, S.G.; Dahl, M.E.; Kafentzis, T.A.; Roosendaal, T.J.

    2012-09-01

    The overall objective of this project was to investigate the effectiveness of nondestructive examination (NDE) technology in detecting material degradation precursors by initiating and growing cracks in selected materials and using NDE methods to measure crack precursors prior to the onset of cracking. Nuclear reactor components are subject to stresses over time that are not precisely known and that make the life expectancy of components difficult to determine. To prevent future issues with the operation of these plants because of unforeseen failure of components, NDE technology is needed that can be used to identify and quantify precursors to macroscopic degradation of materials. Some of the NDE methods being researched as possible solutions to the precursor detection problem are magnetic Barkhausen noise, nonlinear ultrasonics, acoustic emission, eddy current measurements, and guided wave technology. In FY12, the objective was to complete preliminary assessment of advanced NDE techniques for sensitivity to degradation precursors, using prototypical degradation mechanisms in laboratory-scale measurements. This present document reports on the deliverable that meets the following milestone: M3LW-12OR0402143 – Report detailing an initial demonstration on samples from the crack-initiation tests will be provided (demonstrating acceleration of the work).

  19. NDE of copper canisters for long-term storage of spent nuclear fuel from the Swedish nuclear power plants

    Science.gov (United States)

    Stepinski, Tadeusz

    2003-07-01

    Sweden has been intensively developing methods for long term storage of spent fuel from the nuclear power plants for twenty-five years. A dedicated research program has been initiated and conducted by the Swedish company SKB (Swedish Nuclear Fuels and Waste Management Co.). After the interim storage SKB plans to encapsulate spent nuclear fuel in copper canisters that will be placed at a deep repository located in bedrock. The canisters filled with fuel rods will be sealed by an electron beam weld. This paper presents three complementary NDE techniques used for assessing the sealing weld in copper canisters, radiography, ultrasound, and eddy current. A powerful X-ray source and a digital detector are used for the radiography. An ultrasonic array system consisting of a phased ultrasonic array and a multi-channel electronics is used for the ultrasonic examination. The array system enables electronic focusing and rapid electronic scanning eliminating the use of a complicated mechanical scanner. A specially designed eddy current probe capable of detecting small voids at the depth up to 4 mm in copper is used for the eddy current inspection. Presently, all the NDE techniques are verified in SKB's Canister Laboratory where full scale canisters are welded and examined.

  20. Presynaptic miniature GABAergic currents in developing interneurons.

    Science.gov (United States)

    Trigo, Federico F; Bouhours, Brice; Rostaing, Philippe; Papageorgiou, George; Corrie, John E T; Triller, Antoine; Ogden, David; Marty, Alain

    2010-04-29

    Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axonal receptors following random vesicular release. Preminis are prominent in gabaergic synapses made by cerebellar interneurons during the development of the molecular layer. Unlike ordinary miniature postsynaptic currents in the same cells, premini frequencies are strongly enhanced by subthreshold depolarization, suggesting that the membrane depolarization they produce belongs to a feedback loop regulating neurotransmitter release. Thus, preminis could guide the formation of the interneuron network by enhancing neurotransmitter release at recently formed synaptic contacts.

  1. Ultrasonic Phased-Array Characterization for NDE Applications

    Science.gov (United States)

    Hanley, John J.; Tennis, Richard F.; Pickens, Keith S.

    1995-01-01

    Southwest Research Institute (SwRI) recently fabricated and delivered the 100-channel Ultrasonic Phased-Array Testbed System (UPATS) for NASA's Langley Research Center. NASA prepared the specifications and provided the funding to develop UPATS in order to provide a tool for the improvement of ultrasonic nondestructive evaluation (NDE) and characterization of materials. UPATS incorporates state-of-the-art phased-array concepts such as beam steering, focusing, apodization, and phase-sensitive detection which make it possible to develop more sophisticated testing methodologies. It also can be used to investigate fundamental ultrasonic propagation and detection phenomena such as refraction, diffraction, scattering, and beam broadening.

  2. Current challenges in autonomous vehicle development

    Science.gov (United States)

    Connelly, J.; Hong, W. S.; Mahoney, R. B., Jr.; Sparrow, D. A.

    2006-05-01

    The field of autonomous vehicles is a rapidly growing one, with significant interest from both government and industry sectors. Autonomous vehicles represent the intersection of artificial intelligence (AI) and robotics, combining decision-making with real-time control. Autonomous vehicles are desired for use in search and rescue, urban reconnaissance, mine detonation, supply convoys, and more. The general adage is to use robots for anything dull, dirty, dangerous or dumb. While a great deal of research has been done on autonomous systems, there are only a handful of fielded examples incorporating machine autonomy beyond the level of teleoperation, especially in outdoor/complex environments. In an attempt to assess and understand the current state of the art in autonomous vehicle development, a few areas where unsolved problems remain became clear. This paper outlines those areas and provides suggestions for the focus of science and technology research. The first step in evaluating the current state of autonomous vehicle development was to develop a definition of autonomy. A number of autonomy level classification systems were reviewed. The resulting working definitions and classification schemes used by the authors are summarized in the opening sections of the paper. The remainder of the report discusses current approaches and challenges in decision-making and real-time control for autonomous vehicles. Suggested research focus areas for near-, mid-, and long-term development are also presented.

  3. High current ion source development at Frankfurt

    Energy Technology Data Exchange (ETDEWEB)

    Volk, K.; Klein, H.; Lakatos, A.; Maaser, A.; Weber, M. [Frankfurt Univ. (Germany). Inst. fuer Angewandte Physik

    1995-11-01

    The development of high current positive and negative ion sources is an essential issue for the next generation of high current linear accelerators. Especially, the design of the European Spallation Source facility (ESS) and the International Fusion Material Irradiation Test Facility (IFMIF) have increased the significance of high brightness hydrogen and deuterium sources. As an example, for the ESS facility, two H{sup -}-sources each delivering a 70 mA H{sup -}-beam in 1.45 ms pulses at a repetition rate of 50 Hz are necessary. A low emittance is another important prerequisite. The source must operate, while meeting the performance requirements, with a constancy and reliability over an acceptable period of time. The present paper summarizes the progress achieved in ion sources development of intense, single charge, positive and negative ion beams. (author) 16 figs., 7 refs.

  4. Manufacturing and NDE of Large Composite Aerospace Structures at MSFC

    Science.gov (United States)

    Whitaker, Ann

    2000-01-01

    NASA's vision for transportation to orbit calls for new vehicles built with new materials technology. The goals of this new launch system development are to improve safety, dramatically reduce cost to orbit, and improve vehicle turn around time. Planned Space Shuttle upgrades include new reusable liquid propellant boosters to replace the solid propellant boosters. These boosters are to have wings and return to the launch site for a horizontal landing on an airport runway. New single and two stages to orbit concepts are being investigated. To reduce weight and improve performance composite materials are proposed for fuel and oxidizer tanks, fuel feedlines, valve bodies, aerostructures, turbomachinery components. For large composite structures new methods of fabrication are being proposed and developed. Containment of cryogenic fuel or oxidizer requires emphases on composite material densification and chemical compatibility. Ceramic matrix and fiber composites for hot rotating turbomachinery have been developed with new fabrication processes. The new requirements on the materials for launcher components are requiring development of new manufacturing and inspection methods. This talk will examine new and proposed manufacturing methods to fabricate the revolutionary components. New NDE methods under consideration include alternative X-ray methods, X-ray laminagraphy, advanced CT, Thermography, new ultrasonic methods, and imbedded sensors. The sizes, complexity, use environment, and contamination restrictions will challenge the inspection process. In flight self-diagnosis and rapid depot inspection are also goals of the NDE development.

  5. CURRENT ANSTO RESEARCH ON WASTEFORM DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Vance, E.R.; Perera, D.S.; Stewart, M.W.A.; Begg, B.D.; Carter, M.L.; Day, R.A.; Moricca, S.; Smith, K.L.; Lumpkin, G.R.; Hanna, J.V.

    2003-02-27

    Current ANSTO scientific research on wasteform development for mainly high-level radioactive waste is directed towards practical applications. Titanate wasteform products we have developed or are developing are aimed at immobilization of: (a) tank wastes and sludges; (b) U-rich wastes from radioisotope production from reactor irradiation of UO2 targets; (c) Al-rich wastes arising from reprocessing of Al-clad fuels; (d) 99Tc; (e) high- Mo wastes arising from reprocessing of U-Mo fuels and (f) partitioned Cs-rich wastes. Other wasteforms include encapsulated zeolites or silica/alumina beads for immobilization of 129I. Wasteform production techniques cover hot isostatic and uniaxial pressing, sintering, and cold-crucible melting. In addition, building on previous work on speciation and leach resistance of Cs in cementitious products, we are studying geopolymers. Although we have a strong focus on candidate wasteforms for actual wastes, we have a considerable program directed at basic understanding of the wasteforms in regard to crystal chemistry, their dissolution behavior in aqueous media, radiation damage effects and processing techniques.

  6. NADIR: A Flexible Archiving System Current Development

    Science.gov (United States)

    Knapic, C.; De Marco, M.; Smareglia, R.; Molinaro, M.

    2014-05-01

    The New Archiving Distributed InfrastructuRe (NADIR) is under development at the Italian center for Astronomical Archives (IA2) to increase the performances of the current archival software tools at the data center. Traditional softwares usually offer simple and robust solutions to perform data archive and distribution but are awkward to adapt and reuse in projects that have different purposes. Data evolution in terms of data model, format, publication policy, version, and meta-data content are the main threats to re-usage. NADIR, using stable and mature framework features, answers those very challenging issues. Its main characteristics are a configuration database, a multi threading and multi language environment (C++, Java, Python), special features to guarantee high scalability, modularity, robustness, error tracking, and tools to monitor with confidence the status of each project at each archiving site. In this contribution, the development of the core components is presented, commenting also on some performance and innovative features (multi-cast and publisher-subscriber paradigms). NADIR is planned to be developed as simply as possible with default configurations for every project, first of all for LBT and other IA2 projects.

  7. Current development of biorefinery in China.

    Science.gov (United States)

    Tan, Tianwei; Shang, Fei; Zhang, Xu

    2010-01-01

    To meet the demand of its fast growing economy, China has become already the second largest buyer of crude oil. China is facing critical problems of energy shortage and environment deterioration. Rational and efficient energy use and environment protection are both getting more attention in China. Biomass energy is renewable energy made from biological sources. China's biomass resources are abundant, which could provide energy for future social and economic development. However technologies for biomass resource conversion in China are still just beginning. In this paper, current biomass resource distribution and technologies of biomass energy, including power generation, biofuel production and biomass-based chemical production are reviewed. Copyright 2010 Elsevier Inc. All rights reserved.

  8. Current developments in pediatric liver transplantation

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    In 1953, the pioneer of human orthotopic liver transplantation(LT), Thomas E Starzl, was the first to attemptan orthotopic liver transplant into a 3 years old patientsuffering from biliary atresia. Thus, the first LT in humanswas attempted in a disease, which, up until today,remains the main indication for pediatric LT (pLT). Duringthe last sixty years, refinements in diagnostics and surgicaltechnique, the introduction of new immunosuppressivemedications and improvements in perioperative pediatriccare have established LT as routine procedure forchildhood acute and chronic liver failure as well asinherited liver diseases. In contrast to adult recipients,pLT differs greatly in indications for LT, allocation practice,surgical technique, immunosuppression and postoperativelife-long aftercare. Many aspects are focus ofongoing preclinical and clinical research. The presentreview gives an overview of current developments andthe clinical outcome of pLT, with a focus on alternativesto full-size deceased-donor organ transplantation.

  9. NASA DOEPOD NDE Capabilities Data Book

    Science.gov (United States)

    Generazio, Edward R.

    2015-01-01

    This data book contains the Directed Design of Experiments for Validating Probability of Detection (POD) Capability of NDE Systems (DOEPOD) analyses of the nondestructive inspection data presented in the NTIAC, Nondestructive Evaluation (NDE) Capabilities Data Book. DOEPOD is designed as a decision support system to validate inspection system, personnel, and protocol demonstrating 0.90 POD with 95% confidence at critical flaw sizes, a90/95. Although 0.90 POD with 95% confidence at critical flaw sizes is often stated as an inspection requirement in inspection documents, including NASA Standards, NASA critical aerospace applications have historically only accepted 0.978 POD or better with a 95% one-sided lower confidence bound exceeding 0.90 at critical flaw sizes, a90/95.

  10. Current Status of VHTR Technology Development

    Energy Technology Data Exchange (ETDEWEB)

    David Petti; Hans Gougar; Richard Wright; William Windes; Steve Herring; Richard Schultz; Paul Humrickhouse

    2010-10-01

    Abstract – High Temperature Gas-cooled Reactors (HTGRs) featuring particle fuel reached the stage of commercial deployment in the mid-1980s with the Fort St.Vrain and Thorium HochTemperatur Reaktor feeding electricity to the grids in the United States and West Germany, respectively. The technology was then adopted by Japan and China with the operation of the High Temperature Test Reactor in Oarai, Japan and the High Temperature Reactor (HTR-10) in China. Increasing the outlet temperature of the HTGR to even higher temperatures above 900°C will improve the thermodynamic efficiency of the system and enable application of a new class of gas reactor, the very high temperature reactor, to provide process heat, electricity, and hydrogen to chemical industries with the attendant benefits of improved energy security and reduced CO2 emissions. However, the increase in coolant outlet temperature presents a number of technical challenges associated with fuel, materials, power conversion, and analysis methods for the reactor and hydrogen production. The U.S. Department of Energy is sponsoring a broad program of research and development with a goal of addressing the technical challenges over a broad range of outlet temperatures as part of the Next Generation Nuclear Plant Project. This paper describes the research and development activities that are currently underway to realize the technologies needed for an HTGR that features outlet temperatures of 750 to 950°C.

  11. Current developments in equine cataract surgery.

    Science.gov (United States)

    McMullen, R J; Utter, M E

    2010-03-01

    The purpose of this review is to discuss the evolution of equine cataract surgery over the past 50 years to its current stage. Equine cataract surgery is performed similarly compared with the techniques used in human ophthalmology and in other veterinary species. However, enough differences exist to make surgical lens removal and intraocular lens implantation in the horse an intrinsically unique endeavour. Due to the size of the adult equine globe, the introduction of species-specific instrumentation has provided the cornerstone to many of the changes made regarding surgical technique over the last 15-20 years. The continuing development of an equine specific, foldable intraocular lens implant (IOL) has provided much needed data supporting the use of such lenses in the horse to improve upon the post operative visual outcome. Finally, the methods utilised to assess visual capacity and the effects of intraocular lens implantation on the globe (e.g. ocular ultrasonography, electroretinography and streak retinoscopy) are gradually becoming more important in preoperative patient assessment and IOL development in the horse. It is the hope of the authors that a broader group of equine veterinarians will become aware of the many changes that have taken place in equine cataract surgery over the last half-century. Although aspiration was implemented nearly 40 years ago in foals for the treatment of congenital cataracts, phacofragmentation (phacoemulsification) techniques have only recently become routine in mature horses undergoing lens extraction.

  12. Robot-arm-based NDE of hydrogen fuel tank using a 3D-movable HTS-SQUID gradiometer

    Energy Technology Data Exchange (ETDEWEB)

    Hatsukade, Y; Hayashi, K; Tanaka, S [Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi 441-8580 (Japan); Tanabe, K, E-mail: hatukade@eco.tut.ac.j [Superconductivity Research Laboratory, ISTEC, Shinonome 1-chome, Koto-ku, Tokyo 135-0062 (Japan)

    2010-06-01

    In this study, we constructed a robot-arm-based SQUID-NDE system utilizing a novel HTS-SQUID gradiometer with ramp-edge Josephson junctions for hydrogen fuel tank inspection, and developed an automatic 3D-scanning program. A cylindrical hydrogen fuel tank with a double-layer structure, in which a 3mm-thick Al liner was reinforced by a 3mm-thick carbon-fibre reinforced plastic (CFRP) cover, was prepared. The tank had a 10-mm-long through crack in the Al liner made by pressure cycle test. To inspect the tank using the SQUID-NDE system, we adopted a low-frequency eddy current technique that enables to excite deep part in the Al liner. By applying an excitation field of 7.5 {mu}T at 0.4 to 10 kHz to the tank from a double-D coil, the tank was scanned by the system while moving the HTS-SQUID gradiometer along curved surface of the tank in magnetically unshielded environment. Magnetic responses from the deep-lying crack in the tank were successfully detected by the system.

  13. Vaccine development for tuberculosis: current progress.

    Science.gov (United States)

    Orme, Ian M

    2013-07-01

    Very substantial efforts have been made over the past decade or more to develop vaccines against tuberculosis. Historically, this began with a view to replace the current vaccine, Bacillus Calmette Guérin (BCG), but more recently most candidates are either new forms of this bacillus, or are designed to boost immunity in children given BCG as infants. Good progress is being made, but very few have, as yet, progressed into clinical trials. The leading candidate has advanced to phase IIb efficacy testing, with disappointing results. This article discusses the various types of vaccines, including those designed to be used in a prophylactic setting, either alone or BCG-boosting, true therapeutic (post-exposure) vaccines, and therapeutic vaccines designed to augment chemotherapy. While there is no doubt that progress is still being made, we have a growing awareness of the limitations of our animal model screening processes, further amplified by the fact that we still do not have a clear picture of the immunological responses involved, and the precise type of long-lived immunity that effective new vaccines will need to induce.

  14. Vaccine development for tuberculosis: current progress

    Science.gov (United States)

    Orme, Ian M.

    2013-01-01

    Very substantial efforts have been made over the past decade or more to develop vaccines against tuberculosis. Historically, this began with a view to replace the current vaccine, BCG, but more recently most candidates are either new forms of this bacillus, or are designed to boost immunity in children given BCG as infants. Good progress is being made, but very few have as yet progressed into clinical trials. The leading candidate has advanced to Phase IIb efficacy testing, with disappointing results. This article discusses the various types of vaccines, including those designed to be used in a prophylactic setting, either alone or BCG-boosting, true therapeutic [post-exposure] vaccines, and therapeutic vaccines designed to augment chemotherapy. While there is no doubt that progress is still being made, we have a growing awareness of the limitations of our animal model screening processes, further amplified by the fact that we still do not have a clear picture of the immunological responses involved, and the precise type of long lived immunity we will need effective new vaccines to induce. PMID:23794129

  15. Development of BSCCO persistent current system

    Energy Technology Data Exchange (ETDEWEB)

    Joo, Jin Ho; Nah, Wan Soo; Kang, Hyung Koo; Yoo, Jung Hoon [Sungkyunkwan University, Seoul (Korea)

    1998-05-01

    We have developed temperature-variable critical current measurement device for high Tc superconducting wires. For this end, vacuum shroud was designed and fabricated, and that both signal lines and power lines into the vacuum shroud were installed on it. Secondly, the design procedures for the PCS were established for the high Tc superconducting wires based on the electrical circuit analyses during energizations. We have also evaluated mechanical properties such as hardness, strength and elongation of sheath alloys made by addition of Cu, Mg, Ti, Zr and Ni to Ag matrix using induction melting furnace. It was observed that hardness and strength were improved by increasing additive contents from 0.05 to 0.2 at.%. Specifically, the increment of strength was relatively higher for alloys made by addition of Mg, Cu and Zr elements than that made by Ni and Ti addition. On the other hand, elongation was measured to be significantly reduced for former sheath alloy materials. (author). 12 refs., 13 figs., 4 tabs.

  16. WOVOdat: Data Population and Current Development

    Science.gov (United States)

    Ratdomopurbo, A.; Widiwijayanti, C.; Baguet, A.; Lyou, C.; Newhall, C. G.

    2010-12-01

    WOVOdat is the World Organization of Volcano Observatories’ (WOVO) Database of Volcanic Unrest. A large and valuable body of data on volcanic seismicity, ground deformation, gas emission, and other precursory parameters is now being assembled into a single database which later will be open to all and accessible through the WOVOdat website. The project is now hosted at Earth Observatory of Singapore (Nanyang Technological University). Historical data of volcanic unrest, whether that unrest leads to an eruption or not, can be a reference in forecasting of future activity. Forecasts are based mainly on interpretation of present unrest, but comparisons to past unrest and outcomes give a useful context for the first. WOVOdat will help researchers and those responding to volcanic crisis to search for all close matches to some features of unrest in question, and to use modern techniques to find patterns. For eruption data, WOVOdat uses the Smithsonian Institution’s database of historical eruptions. In the current stage of WOVOdat (data population), our website is supports interaction between WOVOdat developers, observatories, and other partners in building the database, e.g. accessing design information and documentation, and also data uploading. When the database is sufficiently complete, this website will provide tools for users to access and query data, and visualize it in time-series and spatial distributions and other ways.

  17. Current Developments in Nuclear Density Functional Methods

    CERN Document Server

    Dobaczewski, J

    2010-01-01

    Density functional theory (DFT) became a universal approach to compute ground-state and excited configurations of many-electron systems held together by an external one-body potential in condensed-matter, atomic, and molecular physics. At present, the DFT strategy is also intensely studied and applied in the area of nuclear structure. The nuclear DFT, a natural extension of the self-consistent mean-field theory, is a tool of choice for computations of ground-state properties and low-lying excitations of medium-mass and heavy nuclei. Over the past thirty-odd years, a lot of experience was accumulated in implementing, adjusting, and using the density-functional methods in nuclei. This research direction is still extremely actively pursued. In particular, current developments concentrate on (i) attempts to improve the performance and precision delivered by the nuclear density-functional methods, (ii) derivations of density functionals from first principles rooted in the low-energy chromodynamics and effective th...

  18. Similarities and differences in bare concrete deck deterioration curves from multi NDE technology surveys

    Science.gov (United States)

    Kim, Jinyoung; Gucunski, Nenad; Dinh, Kien

    2016-04-01

    Reinforced concrete decks are in most cases the fastest deteriorating components of a bridge due to the multitude of influencing factors: direct traffic loading and environmental effects, maintenance activities (salting), etc. Among many deterioration types, corrosion-induced deterioration is the most common problem in reinforced concrete decks. The study concentrates on the condition assessment of bridge decks using complementary NDE techniques. The assessment has three main components: assessment of corrosive environment and corrosion processes, and assessment with respect to the deck delamination. The study concentrates on a complementary use of five NDE techniques: impact echo (IE) to detect and characterize delamination, ground penetrating radar (GPR) to describe the corrosive environment and detect delamination, and electrical resistivity (ER) to estimate the corrosion rate by measuring concrete resistivity. The ability of the NDE methods to objectively characterize deterioration progression is illustrated by the results from NDE surveys of 10 bridges of different ages in New Jersey during a period of one year. The deterioration progression is illustrated by condition maps and condition indices. As demonstrated in the paper, multiple deterioration models are developed utilizing the proposed methodology, which shows high potential for development of more realistic deterioration and life cycle cost models for bridge decks.

  19. Uncertainties in NDE Reliability and Assessing the Impact on RI-ISI

    Energy Technology Data Exchange (ETDEWEB)

    Doctor, Steven R.; Anderson, Michael T.

    2010-08-01

    A major thrust in the past 20 years has been to upgrade nondestructive examinations (NDE) for use in inservice inspection (ISI) programs to more effectively manage degradation at operating nuclear power plants. Risk-informed ISI (RI-ISI) is one of the outcomes of this work, and this approach relies heavily on the reliability of NDE, when properly applied, to detect sources of expected degradation. There have been a number of improvements in the reliability of NDE, specifically in ultrasonic testing (UT), through training of examiners, and improved equipment and procedure development. However, the most significant improvements in UT were derived by moving from prescriptive requirements to performance based requirements. Even with these substantial improvements, NDE contains significant uncertainties and RI-ISI programs need to address and accommodate this factor. As part of the work that PNNL is conducting for the U. S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, we are examining the impact of these uncertainties on the effectiveness of RI-ISI programs.

  20. Digital library research : current developments and trends

    OpenAIRE

    Shiri, Ali

    2003-01-01

    This column gives an overview of current trends in digital library research under the following headings: digital library architecture, systems, tools and technologies; digital content and collections; metadata; interoperability; standards; knowledge organisation systems; users and usability; legal, organisational, economic, and social issues in digital libraries.

  1. Carbohydrate drugs: current status and development prospect.

    Science.gov (United States)

    Zhang, Yan; Wang, Fengshan

    2015-04-01

    In recent years, there has been a great effort devoted to the investigation of the roles of carbohydrates in various essential biological processes and the development of carbohydrates to therapeutic drugs. This review summarizes the carbohydrate drugs which have been recorded in several pharmacopoeias, marketed, and under development. A prospect of the future development of carbohydrate drugs is discussed as well.

  2. Thoughts on the Current Cement Industry Development

    Institute of Scientific and Technical Information of China (English)

    Gan Zhihe

    2003-01-01

    According to the analysis of cement capacity andits relations with macro economy running index, the mainreasons for the present rapid development of cement capacityare the rapid development of economy and the shot up ofwhole society fixed asset investment. According to the presentspeed of economy development, cement still enjoys a po-tential increase, So here has not been an overall excessivepopularity of cement industry. The best way to prevent lowlevel repeated construction is to promote the development ofnew dry- process cement as well as try to get rid of blindness.

  3. Advancements in NDE for utilities and the petrochemical industry through electromagnetic acoustic transducers (EMATs)

    Science.gov (United States)

    Robertson, M. O.; Stevens, Donald M.; Schlader, Daniel M.; Tilley, Richard M.

    1998-03-01

    The ultrasonic testing (UT) method continues to broaden in its effectiveness and capabilities for nondestructive evaluation (NDE). Much of this expansion can be attributed to advancements in specific techniques of the method. The utilization of electromagnetic acoustic transducers (EMATs) in dedicated ultrasonic systems has provided McDermott Technology, Inc. (MTI), formerly Babcock & Wilcox, with significant advantages over conventional ultrasonics. In recent years, through significant R&D, MTI has been instrumental in bringing about considerable advancements in the maturing EMAT technology. Progress in electronic design, magnet configurations, and sensor concepts has greatly improved system capabilities while reducing cost and equipment size. These improvements, coupled with the inherent advantages of utilizing the non-contact EMAT technique, have combined to make this technology a viable option for many commercial system inspection applications. MTI has recently completed the development and commercialization of an EMAT-based UT scanner for boiler tube thickness measurements. MTI is currently developing an automated EMAT scanner, based on phased array technology, for complete volumetric inspection of circumferential girth welds associated with pipelines (intended primarily for offshore applications). Additional benefits of phased array technology for providing materials characterization are currently being researched.

  4. Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, K.L.; Ramuhali, P.; Brenchley, D.L.; Coble, J.B.; Hashemian, H.M.; Konnick, R.; Ray, S.

    2012-09-01

    Executive Summary [partial] The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. A workshop was held to gather subject matter experts to develop the NDE R&D Roadmap for Cables. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, and NDE instrumentation development from the U.S. Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineering Laboratory), universities, commercial NDE service vendors and cable manufacturers, and the Electric Power Research Institute (EPRI).

  5. Current European developments in solar paddle drives

    Science.gov (United States)

    Bentall, R. H.

    1973-01-01

    The European Space Research and Technology Centre (ESTEC) is sponsoring the development of a number of critical spacecraft hardware items. The hardware under development includes two competing solar paddle drives which are being produced to similar specifications. Three mechanisms of each type are being produced and will undergo thermal vacuum testing. All mechanisms have lead lubricated bearings.

  6. Fuel cells: a survey of current developments

    Science.gov (United States)

    Cropper, Mark A. J.; Geiger, Stefan; Jollie, David M.

    Since the first practical uses of fuel cells were developed, it has become clear that they could find use in many products over a wide power range of milliwatts to tens of megawatts. Throughout the 1990s, and later, there has been significant work carried out on adapting the various different fuel cell technologies for use in targetted consumer and industrial applications. This paper discusses these developments and gives details on the specific market segments for providing power to vehicles, portable devices and large- and small-scale stationary power generation.

  7. Current developments in silicene and germanene

    KAUST Repository

    Kaloni, T. P.

    2016-01-18

    Exploration of the unusual properties of the two-dimensional materials silicene and germanene is a very active research field in recent years. This paper therefore reviews the latest developments, focusing both on the fundamental materials properties and on possible applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Energy-conserving development regulations: current practice

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    Almost every aspect of land development has an effect on energy use, from minute architectural details to broad considerations of urban density. Energy-efficiency depends in part on how development is planned and carried out. Conventional development regulations, such as zoning ordinances and subdivision regulations, can be adapted in many ways to promote energy conservation at the community level. This report is about energy-efficient site and neighborhood design. It examines recent experiences of local governments that have adopted new development regulations or amended existing ones to promote energy conservation, more efficient generation and distribution, or a switch to alternative, renewable sources. Although much has been written in recent years about saving energy through community design, actual experience in applying these new ideas is still limited. To date, most communities have focused their efforts on studying the problem, documenting consumption patterns, and writing reports and plans. Only a handful have amended their land-use controls for the express purpose of saving energy. This study identifies 13 of these pioneering communities, after undertaking a survey of over 1400 local, regional, and state planning agencies. It takes a look at their experiences, to learn what has been done, how well it has worked, and what problems have been encountered.

  9. Vaccination Against Dengue: Challenges and Current Developments.

    Science.gov (United States)

    Guy, Bruno; Lang, Jean; Saville, Melanie; Jackson, Nicholas

    2016-01-01

    Dengue is a growing threat worldwide, and the development of a vaccine is a public health priority. The completion of the active phase of two pivotal efficacy studies conducted in Asia and Latin America by Sanofi Pasteur has constituted an important step. Several other approaches are under development, and whichever technology is used, vaccine developers face several challenges linked to the particular nature and etiology of dengue disease. We start our review by defining questions and potential issues linked to dengue pathology and presenting the main types of vaccine approaches that have explored these questions; some of these candidates are in a late stage of clinical development. In the second part of the review, we focus on the Sanofi Pasteur dengue vaccine candidate, describing the steps from research to phase III efficacy studies. Finally, we discuss what could be the next steps, before and after vaccine introduction, to ensure that the vaccine will provide the best benefit with an acceptable safety profile to the identified target populations.

  10. [Development and current status of perforator flaps].

    Science.gov (United States)

    Xu, Dachuan; Zhang, Shimin; Tang, Maolin; Ouyang, Jun

    2011-09-01

    To provide a comprehensive review for development and existing problems of the perforator flaps. The related home and abroad literature concerning perforator flaps was extensively reviewed. The perforator flaps are defined as the axial flaps nourished solely by small cutaneous perforating vessels (perforating arteries and veins), which are exclusively composed of skin and subcutaneous fat. The perforator flaps have the advantages as follows: less injury at donor site, less damage to the contour of the donor site, good reconstruction and appearance of the recipient site flexible design, and short time of postoperative recovery, which have been widely used in reconstructive surgery. The perforator flaps are the new development of the microsurgery, which usher an era of small axial flaps; However, the controversies of the definition, vascular classification, the nomenclature, and the clinical application of the perforator flaps still exist, which are therefore the hot spot for future study.

  11. Bacterial otitis media: current vaccine development strategies.

    Science.gov (United States)

    Cripps, Allan W; Kyd, Jennelle

    2003-02-01

    Otitis media is the most common reason for children less than 5 years of age to visit a medical practitioner. Whilst the disease rarely results in death, there is significant associated morbidity. The most common complication is loss of hearing at a critical stage of the development of speech, language and cognitive abilities in children. The cause and pathogenesis of otitis media is multifactorial. Among the contributing factors, the single most important are viral and bacterial infections. Infection with respiratory syncytial virus, influenza viruses, para-influenza viruses, enteroviruses and adenovirus are most commonly associated with acute and chronic otitis media. Streptococcus pneumoniae, non-typeable Haemophilus influenzae and Moraxella catarrhalis are the most commonly isolated bacteria from the middle ears of children with otitis media. Treatment of otitis media has largely relied on the administration of antimicrobials and surgical intervention. However, attention has recently focused on the development of a vaccine. For a vaccine to be effective against bacterial otitis media, it must, at the very least, contain antigens that induce a protective immune response in the middle ear against the three most common infecting bacteria. Whilst over the past decade there has been significant progress in the development of vaccines against invasive S. pneumoniae disease, these vaccines are less efficacious for otitis media. The search for candidate vaccine antigens for non-typeable H. influenzae are well advanced whilst less progress has been made for M. catarrhalis. No human studies have been conducted for non-typeable H. influenzae or M. catarrhalis and the concept of a tribacterial vaccine remains to be tested in animal models. Only when vaccine antigens are determined and an understanding of the immune responses induced in the middle ear by infection and immunization is gained will the formulation of a tribacterial vaccine against otitis media be possible.

  12. [Current status and development of kidney transplantation].

    Science.gov (United States)

    Kirste, G

    1993-01-01

    Since the first successful procedure in 1954 kidney transplantation has become a standard therapy of end stage renal disease. The knowledge of immunoregulation and immune response of the body has enabled people to recognize acute rejection of organs. HLA-testing and organ exchange on basis of HLA-compatibility are extremely important for a successful kidney transplantation. A shortage of organs is limiting the further increase of transplantations. Chronic rejection is in most cases the reason for late graft failure. Further investigations to develop new immunosuppressive drugs and to clarify immunological processes underlying chronic rejections are necessary in the future.

  13. Current status of biodiesel development in Brazil.

    Science.gov (United States)

    Ramos, Luiz Pereira; Wilhelm, Helena Maria

    2005-01-01

    In recent years, the concept of producing biodiesel from renewable lipid sources has regained international attention. In Brazil, a national program was launched in 2002 to evaluate the technical, economic, and environmental competitiveness of biodiesel in relation to the commercially available diesel oil. Several research projects were initiated nationwide to investigate and/or optimize biodiesel production from renewable lipid sources and ethanol derived from sugarcane (ethyl esters). Once implemented, this program will not only decrease our dependence on petroleum derivatives but also create new market opportunities for agribusiness, opening new jobs in the countryside, improving the sustainability of our energy matrix, and helping the Brazilian government to support important actions against poverty. This article discusses the efforts to develop the Brazilian biodiesel program in the context of technical specifications as well as potential oilseed sources.

  14. Current scenario of drug development for leishmaniasis.

    Science.gov (United States)

    Croft, Simon L; Seifert, Karin; Yardley, Vanessa

    2006-03-01

    Although three new drugs or drug formulations, liposomal amphotericin B (AmBisome), miltefosine and paromomycin should be available for the treatment of visceral leishmaniasis (VL) within the next year, they all suffer from limitations of either cost, specific toxicities or parenteral administration. As part of research to identify better treatments for VL and cutaneous leishmaniasis (CL), alternative and potentially cheaper formulations of amphotericin B, alklyphosphocholines other than miltefosine and improved formulations of paromomycin for CL have been identified. Other drugs or compounds that have demonstrated activity in experimental rodent models of infection include licochalcone derivatives, quinoline derivatives, bisphosphonates and a maesabalide; further chemistry based upon these leads is warranted. The process for discovery and development of new antileishmanials would also benefit from improved models, for example, transfected parasites, and non invasive methods of measuring parasite load in rodent models of infection.

  15. Current development and application of soybean genomics

    Institute of Scientific and Technical Information of China (English)

    Lingli HE; Jing ZHAO; Man ZHAO; Chaoying HE

    2011-01-01

    Soybean (Glycine max),an important domesticated species originated in China,constitutes a major source of edible oils and high-quality plant proteins worldwide.In spite of its complex genome as a consequence of an ancient tetraploidilization,platforms for map-based genomics,sequence-based genomics,comparative genomics and functional genomics have been well developed in the last decade,thus rich repertoires of genomic tools and resources are available,which have been influencing the soybean genetic improvement.Here we mainly review the progresses of soybean (including its wild relative Glycine soja) genomics and its impetus for soybean breeding,and raise the major biological questions needing to be addressed.Genetic maps,physical maps,QTL and EST mapping have been so well achieved that the marker assisted selection and positional cloning in soybean is feasible and even routine.Whole genome sequencing and transcriptomic analyses provide a large collection of molecular markers and predicted genes,which are instrumental to comparative genomics and functional genomics.Comparative genomics has started to reveal the evolution of soybean genome and the molecular basis of soybean domestication process.Microarrays resources,mutagenesis and efficient transformation systems become essential components of soybean functional genomics.Furthermore,phenotypic functional genomics via both forward and reverse genetic approaches has inferred functions of many genes involved in plant and seed development,in response to abiotic stresses,functioning in plant-pathogenic microbe interactions,and controlling the oil and protein content of seed.These achievements have paved the way for generation of transgenic or genetically modified (GM) soybean crops.

  16. Development of Meandering Winding Magnetometer (MWM (Register Trademark)) Eddy Current Sensors for the Health Monitoring, Modeling and Damage Detection of High Temperature Composite Materials

    Science.gov (United States)

    Russell, Richard; Washabaugh, Andy; Sheiretov, Yanko; Martin, Christopher; Goldfine, Neil

    2011-01-01

    The increased use of high-temperature composite materials in modern and next generation aircraft and spacecraft have led to the need for improved nondestructive evaluation and health monitoring techniques. Such technologies are desirable to improve quality control, damage detection, stress evaluation and temperature measurement capabilities. Novel eddy current sensors and sensor arrays, such as Meandering Winding Magnetometers (MWMs) have provided alternate or complimentary techniques to ultrasound and thermography for both nondestructive evaluation (NDE) and structural health monitoring (SHM). This includes imaging of composite material quality, damage detection and .the monitoring of fiber temperatures and multidirectional stresses. Historically, implementation of MWM technology for the inspection of the Space Shuttle Orbiter Reinforced Carbon-Carbon Composite (RCC) leading edge panels was developed by JENTEK Sensors and was subsequently transitioned by NASA as an operational pre and post flight in-situ inspection at the Kennedy Space Center. A manual scanner, which conformed'automatically to the curvature of the RCC panels was developed and used as a secondary technique if a defect was found during an infrared thermography screening, During a recent proof of concept study on composite overwrapped pressure vessels (COPV's), three different MWM sensors were tested at three orientations to demonstrate the ability of the technology to measure stresses at various fiber orientations and depths. These results showed excellent correlation with actual surface strain gage measurements. Recent advancements of this technology have been made applying MWM sensor technology for scanning COPVs for mechanical damage. This presentation will outline the recent advance in the MWM.technology and the development of MWM techniques for NDE and SHM of carbon wraped composite overwrapped pressure vessels (COPVs) including the measurement of internal stresses via a surface mounted sensor

  17. Studying the nonlinearity in Sonic IR NDE

    Science.gov (United States)

    Yu, Qiuye; Obeidat, Omar; Han, Xiaoyan

    2017-02-01

    Sonic IR Imaging combines pulsed ultrasound excitation and infrared imaging to detect defects in materials. The sound pulse causes rubbing due to non--unison motion between faces of defects, and infrared sensors image the temperature map over the target to identify defects. It works in various materials, including metal/metal alloy, ceramics, and composite materials. Its biggest advantage is that it's a fast, wide area NDE technique. It takes only a fraction of a second or a few seconds, depending on the thermal properties of the target, for one test over a few square feet. However, due to the nonlinearity in the coupling between the ultrasound transducer and the target, the repeatability has been an issue, which affects its application. In this paper, we present our study on this issue in Sonic IR.

  18. Automated metrology and NDE measurements for increased throughput in aerospace component manufacture

    Science.gov (United States)

    MacLeod, Charles N.; Pierce, S. Gareth; Morozov, Maxim; Summan, Rahul; Dobie, Gordon; McCubbin, Paul; McCubbin, Coreen; Dearie, Scott; Munro, Gavin

    2015-03-01

    Composite materials, particularly Carbon-Fibre-Reinforced Polymer (CFRP), find extensive use in construction of modern airframe structures. Quality and conformance checks can be a serious limitation on production throughput in aerospace manufacturing. Traditionally Non-Destructive Evaluation (NDE) and metrology measurements are undertaken at different stages of a product manufacture cycle using specific dedicated equipment and personnel. However, since both processes involve direct interaction with the component's surface, an opportunity exists to combine these to potentially reduce overall cycle time. In addition when considering moves towards automation of both inspection processes, it is clear that measured metrology data is an essential input parameter to the automated NDE workflow. The authors present the findings of a proof of concept combined sub-scale NDE and Metrology demonstrator cell for aerospace components. Permitting a maximum part area size of 3 × 1 m2, KUKA KR5 6 degree of freedom robotic manipulators were utilised to deploy two inspection payloads. Firstly automated non-contact photogrammetric metrology measurement was employed to inspect the structure for conformance of dimension in relation to reference designs (available from CAD). Secondly automated phased array technology was deployed to inspect and produce ultrasonic thickness mapping of components of nominal 20mm thickness. Parameters such as overall cycle time, part dimensional accuracy, robotic path accuracy and data registration are assessed in the paper to highlight both the current state of the art performance available and the future direction of required research focus.

  19. Structural Analysis of Composite Flywheels: an Integrated NDE and FEM Approach

    Science.gov (United States)

    Abdul-Aziz, Ali; Baaklini, George; Trudell, Jeffrey

    2001-01-01

    A structural assessment by integrating finite-element methods (FEM) and a nondestructive evaluation (NDE) of two flywheel rotor assemblies is presented. Composite rotor A is pancake-like with a solid hub design, and composite rotor B is cylindrical with a hollow hub design. Detailed analyses under combined centrifugal and interference-fit loading are performed. Two- and three-dimensional stress analyses and two-dimensional fracture mechanics analyses are conducted. A comparison of the structural analysis results obtained with those extracted via NDE findings is reported. Contact effects due to press-fit conditions are evaluated. Stress results generated from the finite-element analyses were corroborated with the analytical solution. Cracks due to rotational loading up to 48,000 rpm for rotor A and 34,000 rpm for rotor B were successfully imaged with NDE and predicted with FEM and fracture mechanics analyses. A procedure that extends current structural analysis to a life prediction tool is also defined.

  20. Material property relationships for pipeline steels and the potential for application of NDE

    Science.gov (United States)

    Smart, Lucinda; Bond, Leonard J.

    2016-02-01

    The oil and gas industry in the USA has an extensive infrastructure of pipelines, 70% of which were installed prior to 1980, and almost half were installed during the 1950s and 1960s. Ideally the mechanical properties (i.e. yield strength, tensile strength, transition temperature, and fracture toughness) of a steel pipe must be known in order to respond to detected defects in an appropriate manner. Neither current in-ditch methods nor the ILI inspection data have yet determined and map the desired mechanical properties with adequate confidence. In the quest to obtain the mechanical properties of a steel pipe using a nondestructive method, it is important to understand that there are many inter-related variables. This paper reports a literature review and an analysis of a sample set of data. There is promise for correlating the results of NDE measurement modalities to the information required to develop relationships between those measurements and the mechanical measurements desired for pipelines to ensure proper response to defects which are of significant threat.

  1. Assessment of NDE Technologies for Detection and Characterization of Stress Corrosion Cracking in LWRs

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ryan M.; Ramuhalli, Pradeep; Toloczko, Mychailo B.; Bond, Leonard J.; Montgomery, Robert O.

    2012-12-31

    Stress corrosion cracking (SCC) in light water reactors (LWRs) has been a persistent form of degradation in the nuclear industry. Examples of SCC can be found for a range of materials in boiling and pressurized water reactor environments, including carbon steels, stainless steels, and nickel-base stainless alloys. The evolution of SCC is often characterized by a long initiation stage followed by a phase of more rapid crack growth to failure. This provides a relatively short window of opportunity to detect the start of observable SCC, and it is conceivable that SCC could progress from initiation to failure between subsequent examinations when managed by applying periodic in-service inspection techniques. Implementation of advanced aging management paradigms in the current fleet of LWRs will require adaptation of existing measurement technologies and development of new technologies to perform on-line measurements during reactor operation to ensure timely detection of material degradation and to support the implementation of advanced diagnostics and prognostics. This paper considers several non-destructive examination (NDE) technologies with known sensitivity to detection of indicators for SCC initiation and/or propagation, and assesses these technologies with respect to their ability to detect and accurately characterize the significance of an SCC flaw. Potential strategies to improve SCC inspection or monitoring performance are offered to benefit management of SCC degradation in LWRs.

  2. Explorer-II: Wireless Self-Powered Visual and NDE Robotic Inspection System for Live Gas Distribution Mains

    Energy Technology Data Exchange (ETDEWEB)

    Carnegie Mellon University

    2008-09-30

    and their arrangement, still allow the robot to configure itself to perform any-angle (up to 90 deg) turns in any orientation (incl. vertical), and enable the live launching and recovery of the system using custom fittings and a (to be developed) launch-chamber/-tube. The battery modules are used to power the system, by providing power to the robot's bus. The support modules perform the functions of centration for the rest of the train as well as odometry pickups using incremental encoding schemes. The electronics architecture is based on a distributed (8-bit) microprocessor architecture (at least 1 in ea. module) communicating to a (one of two) 32-bit SBC, which manages all video-processing, posture and motion control as well as CAN and wireless communications. The operator controls the entire system from an off-board (laptop) controller, which is in constant wireless communication with the robot train in the pipe. The sensor modules collect data and forward it to the robot operator computer (via the CAN-wireless communications chain), who then transfers it to a dedicated NDE data-storage and post-processing computer for further (real-time or off-line) analysis. The prototype robot system was built and tested indoors and outdoors, outfitted with a Remote-Field Eddy Current (RFEC) sensor integrated as its main NDE sensor modality. An angled launcher, allowing for live launching and retrieval, was also built to suit custom angled launch-fittings from TDW. The prototype vehicle and launcher systems are shown. The complete system, including the in-pipe robot train, launcher, integrated NDE-sensor and real-time video and control console and NDE-data collection and -processing and real-time display, were demonstrated to all sponsors prior to proceeding into final field-trials--the individual components and setting for said acceptance demonstration are shown. The launcher-tube was also used to verify that the vehicle system is capable of operating in high

  3. Continued Development of Meandering Winding Magnetometer (MWM (Register Trademark)) Eddy Current Sensors for the Health Monitoring, Modeling and Damage Detection of Composite Overwrapped Pressure Vessels

    Science.gov (United States)

    Russell, Richard; Wincheski, Russell; Jablonski, David; Washabaugh, Andy; Sheiretov, Yanko; Martin, Christopher; Goldfine, Neil

    2011-01-01

    Composite Overwrapped Pressure Vessels (COPVs) are used in essentially all NASA spacecraft, launch. vehicles and payloads to contain high-pressure fluids for propulsion, life support systems and science experiments. Failure of any COPV either in flight or during ground processing would result in catastrophic damage to the spacecraft or payload, and could lead to loss of life. Therefore, NASA continues to investigate new methods to non-destructively inspect (NDE) COPVs for structural anomalies and to provide a means for in-situ structural health monitoring (SHM) during operational service. Partnering with JENTEK Sensors, engineers at NASA, Kennedy Space Center have successfully conducted a proof-of-concept study to develop Meandering Winding Magnetometer (MWM) eddy current sensors designed to make direct measurements of the stresses of the internal layers of a carbon fiber composite wrapped COPV. During this study three different MWM sensors were tested at three orientations to demonstrate the ability of the technology to measure stresses at various fiber orientations and depths. These results showed good correlation with actual surface strain gage measurements. MWM-Array technology for scanning COPVs can reliably be used to image and detect mechanical damage. To validate this conclusion, several COPVs were scanned to obtain a baseline, and then each COPV was impacted at varying energy levels and then rescanned. The baseline subtracted images were used to demonstrate damage detection. These scans were performed with two different MWM-Arrays. with different geometries for near-surface and deeper penetration imaging at multiple frequencies and in multiple orientations of the linear MWM drive. This presentation will include a review of micromechanical models that relate measured sensor responses to composite material constituent properties, validated by the proof of concept study, as the basis for SHM and NDE data analysis as well as potential improvements including

  4. Global NDE Best Practice for Technology Improvement, Outage Management, Foreign Material Exclusion and Dose Control

    Energy Technology Data Exchange (ETDEWEB)

    Glass, S. W.; Mohr, F.

    2010-07-01

    Non Destructive Examination (NDE) is a critical element of both Boiling Water and Pressurized Water Reactor outages. Frequently this includes critical path activity so both the utility and the inspection vendor are under intense pressure to perform the work quickly. Concurrent with AREVA's new global organization of NDE resources, AREVA NDE SOLUTIONS, efforts have intensified for global application of lessons learned and best practices. These best practices include new developments as well as continuous improvements to well established tools and NDE techniques. Advancements range from steam generator robots, advanced steam generator deposit characterization sensors and method, new phased array approaches for PWR and BWR reactor vessel examination, new sensors and approaches for RPV head examinations, plus advanced internals examination robots and methods. In addition to specialized tools and techniques, best practice includes numerous management innovations. AREVA's multi-disciplined integrated nuclear worker strategy helps to minimize the total number of personnel deployed to multi-task outages. Specific design and on-site practice has been implemented to minimize or eliminate foreign material from the reactor system and vigorous pursuit of dose management practices keeps our nuclear worker dose as low as reasonably achievable. The industry is moving to much more conservative nuclear worker dose limits. While this is proving to be an issue with many vendors, AREVA has had an internal policy of <2R since 2006. Globalizing the organization also helps AREVA manage peaks and unplanned emergency inspections from an enlarged pool of globally qualified inspection personnel and tools. (Author)

  5. Nondestructive Evaluation (NDE) for Characterizing Oxidation Damage in Cracked Reinforced Carbon-Carbon (RCC)

    Science.gov (United States)

    Roth, Don J.; Rauser, Richard W.; Jacobson, Nathan S.; Wincheski, Russell A.; Walker, James L.; Cosgriff, Laura A.

    2009-01-01

    In this study, coated reinforced carbon-carbon (RCC) samples of similar structure and composition as that from the NASA space shuttle orbiter's thermal protection system were fabricated with slots in their coating simulating craze cracks. These specimens were used to study oxidation damage detection and characterization using nondestructive evaluation (NDE) methods. These specimens were heat treated in air at 1143 and 1200 C to create cavities in the carbon substrate underneath the coating as oxygen reacted with the carbon and resulted in its consumption. The cavities varied in diameter from approximately 1 to 3 mm. Single-sided NDE methods were used since they might be practical for on-wing inspection, while x-ray micro-computed tomography (CT) was used to measure cavity sizes in order to validate oxidation models under development for carbon-carbon materials. An RCC sample having a naturally-cracked coating and subsequent oxidation damage was also studied with x-ray micro-CT. This effort is a follow-on study to one that characterized NDE methods for assessing oxidation damage in an RCC sample with drilled holes in the coating.

  6. Nondestructive Evaluation (NDE) for Characterizing Oxidation Damage in Cracked Reinforced Carbon-Carbon

    Science.gov (United States)

    Roth, Don J.; Jacobson, Nathan S.; Rauser, Richard W.; Wincheski, Russell A.; Walker, James L.; Cosgriff, Laura A.

    2010-01-01

    In this study, coated reinforced carbon-carbon (RCC) samples of similar structure and composition as that from the NASA space shuttle orbiter's thermal protection system were fabricated with slots in their coating simulating craze cracks. These specimens were used to study oxidation damage detection and characterization using nondestructive evaluation (NDE) methods. These specimens were heat treated in air at 1143 C and 1200 C to create cavities in the carbon substrate underneath the coating as oxygen reacted with the carbon and resulted in its consumption. The cavities varied in diameter from approximately 1 to 3mm. Single-sided NDE methods were used because they might be practical for on-wing inspection, while X-ray micro-computed tomography (CT) was used to measure cavity sizes in order to validate oxidation models under development for carbon-carbon materials. An RCC sample having a naturally cracked coating and subsequent oxidation damage was also studied with X-ray micro-CT. This effort is a follow-on study to one that characterized NDE methods for assessing oxidation damage in an RCC sample with drilled holes in the coating.

  7. Results of NDE Technique Evaluation of Clad Hydrides

    Energy Technology Data Exchange (ETDEWEB)

    Kunerth, Dennis C. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-09-01

    This report fulfills the M4 milestone, M4FT-14IN0805023, Results of NDE Technique Evaluation of Clad Hydrides, under Work Package Number FT-14IN080502. During service, zirconium alloy fuel cladding will degrade via corrosion/oxidation. Hydrogen, a byproduct of the oxidation process, will be absorbed into the cladding and eventually form hydrides due to low hydrogen solubility limits. The hydride phase is detrimental to the mechanical properties of the cladding and therefore it is important to be able to detect and characterize the presence of this constituent within the cladding. Presently, hydrides are evaluated using destructive examination. If nondestructive evaluation techniques can be used to detect and characterize the hydrides, the potential exists to significantly increase test sample coverage while reducing evaluation time and cost. To demonstrate the viability this approach, an initial evaluation of eddy current and ultrasonic techniques were performed to demonstrate the basic ability to these techniques to detect hydrides or their effects on the microstructure. Conventional continuous wave eddy current techniques were applied to zirconium based cladding test samples thermally processed with hydrogen gas to promote the absorption of hydrogen and subsequent formation of hydrides. The results of the evaluation demonstrate that eddy current inspection approaches have the potential to detect both the physical damage induced by hydrides, e.g. blisters and cracking, as well as the combined effects of absorbed hydrogen and hydride precipitates on the electrical properties of the zirconium alloy. Similarly, measurements of ultrasonic wave velocities indicate changes in the elastic properties resulting from the combined effects of absorbed hydrogen and hydride precipitates as well as changes in geometry in regions of severe degradation. However, for both approaches, the signal responses intended to make the desired measurement incorporate a number of contributing

  8. 3. European-American workshop on reliability of NDE and demining. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This proceeding contains 43 lectures and three posters relating to the following main topics: 1. Understanding reliability, validation and structuring the Reliability Formula; 2. Special considerations for demining reliability; 3. Essential quality characteristics for NDE; 4. NDE reliability in risk and life cycle management; 5. Modelling of NDE processes; 6. Approaches for modular validation and modelling results for NDE and demining; 7. Statistical test design ad analysis; 8. Human factors. (MM)

  9. Bulgarian-Polish Language Resources (Current State and Future Development

    Directory of Open Access Journals (Sweden)

    Ludmila Dimitrova

    2015-06-01

    Full Text Available Bulgarian-Polish Language Resources (Current State and Future Development The paper briefly reviews the first Bulgarian-Polish digital bilingual resources: corpora and dictionaries, which are currently developed under bilateral collaboration between IMI-BAS and ISS-PAS: joint research project “Semantics and contrastive linguistics with a focus on a bilingual electronic dictionary”, coordinated by L. Dimitrova (IMI-BAS and V. Koseska (ISS-PAS.

  10. Preview of the NASA NNWG NDE Sample Preparation Handbook

    Science.gov (United States)

    2010-01-01

    This viewgraph presents a step-by-step how-to fabrication documentation of every kind of sample that is fabricated for MSFC by UA Huntsville, including photos and illustrations. The tabulation of what kind of samples are being fabricated for what NDE method, detailed instructions/documentation of the inclusion/creation of defects, detailed specifications for materials, processes, and equipment, case histories and/or experiences with the different fabrication methods and defect inclusion techniques, discussion of pitfalls and difficulties associated with sample fabrication and defect inclusion techniques, and a discussion of why certain fabrication techniques are needed as related to the specific NDE methods are included in this presentation.

  11. Current Situations and Developing Tendency of China Post's Logistic Technology

    Institute of Scientific and Technical Information of China (English)

    XU Ru-wei; LI Xue-ping

    2004-01-01

    This paper briefly introduces the construction of China Post's physical network and information network and offers some general ideas about how to develop modern postal logistics. It dwells on the sortation technology, the Chinese Character Recognition Technology and the current situations and tendencies of the Research and Development (R&D) of the Logistic Information Management System.

  12. Lifelong Education in Greece: Recent Developments and Current Trends

    Science.gov (United States)

    Karalis, Thanassis; Vergidis, Dimitris

    2004-01-01

    This article concerns recent developments and current trends in lifelong education in Greece, specifically those related with funding from European Social Fund (ESF). The analysis undertaken focuses mainly on (a) the expansion of continuing training activities in Greece during the past ten years and the development of new training organizations as…

  13. A Simple Electromagnetic Analysis of Magnetic NDE Using a Double Rectangular Coil an a Hall Effect Sensor

    Directory of Open Access Journals (Sweden)

    L. Bettaieb

    2012-12-01

    Full Text Available In this paper a simple analysis and measurement in eddy current NDE are presented. A Hall probe is associated to a double Printed Circuit Board PCB. The configurations examined involve the coil in air and the coil above aluminum plates, either with or without cracks of various depths. The agreement between experimental and theoretical results is very good, showing that a very simple model accurately describes the electromagnetic fields.

  14. Explorer-II: Wireless Self-Powered Visual and NDE Robotic Inspection System for Live Gas Distribution Mains

    Energy Technology Data Exchange (ETDEWEB)

    Carnegie Mellon University

    2008-09-30

    and their arrangement, still allow the robot to configure itself to perform any-angle (up to 90 deg) turns in any orientation (incl. vertical), and enable the live launching and recovery of the system using custom fittings and a (to be developed) launch-chamber/-tube. The battery modules are used to power the system, by providing power to the robot's bus. The support modules perform the functions of centration for the rest of the train as well as odometry pickups using incremental encoding schemes. The electronics architecture is based on a distributed (8-bit) microprocessor architecture (at least 1 in ea. module) communicating to a (one of two) 32-bit SBC, which manages all video-processing, posture and motion control as well as CAN and wireless communications. The operator controls the entire system from an off-board (laptop) controller, which is in constant wireless communication with the robot train in the pipe. The sensor modules collect data and forward it to the robot operator computer (via the CAN-wireless communications chain), who then transfers it to a dedicated NDE data-storage and post-processing computer for further (real-time or off-line) analysis. The prototype robot system was built and tested indoors and outdoors, outfitted with a Remote-Field Eddy Current (RFEC) sensor integrated as its main NDE sensor modality. An angled launcher, allowing for live launching and retrieval, was also built to suit custom angled launch-fittings from TDW. The prototype vehicle and launcher systems are shown. The complete system, including the in-pipe robot train, launcher, integrated NDE-sensor and real-time video and control console and NDE-data collection and -processing and real-time display, were demonstrated to all sponsors prior to proceeding into final field-trials--the individual components and setting for said acceptance demonstration are shown. The launcher-tube was also used to verify that the vehicle system is capable of operating in high

  15. Current development of UAV sense and avoid system

    Science.gov (United States)

    Zhahir, A.; Razali, A.; Mohd Ajir, M. R.

    2016-10-01

    As unmanned aerial vehicles (UAVs) are now gaining high interests from civil and commercialised market, the automatic sense and avoid (SAA) system is currently one of the essential features in research spotlight of UAV. Several sensor types employed in current SAA research and technology of sensor fusion that offers a great opportunity in improving detection and tracking system are presented here. The purpose of this paper is to provide an overview of SAA system development in general, as well as the current challenges facing UAV researchers and designers.

  16. DR-current intensity variations during substorm development

    Science.gov (United States)

    Zaitseva, S. A.; Drobinina, T. A.; Pudovkin, M. I.

    2003-04-01

    According to the concept dominated by the last time, the intensification of the DR-current takes place during the polar substorm development. In the recent papers Iyemori and Rao claim that geomagnetic storms and substorms are independent processes, and SYM-index (essentially the same as Dst-index) tends to decay after the onset of substorms. In this paper we tried to clear up the cause of this contradiction by studying the connection of ring current development with polar substorms basing on the new data: ASY-, SYM-indices describing asymmetric and symmetric parts of DR-current correspondingly and AL-index as a measure of polar disturbances. It is shown that the hourly-mean SYM- and ASY-indices correlate with AL-index (r=0.63 and 0.69 correspondingly), and the connection between these values becomes worse for strong storms. Besides, at the substorm expansive phase onset, the energy can put mainly to the asymmetric part rather than into symmetric part of DR-current. Empirical Q-index based on solar wind parameters describes the energy input into DR-current; Q correlates rather well with SYM, ASY and AL-indices. Thus the intensifications of polar disturbances and DR-current take place simultaneously and have the same source.At the same time, the proportion in which the solar wind energy is distributed between the DR-current, polar ionosphere and magnetotail depends on the Dst variation phase.

  17. Development of Low-Cost Current Controlled Stimulator for Paraplegics

    Directory of Open Access Journals (Sweden)

    Aizan Masdar

    2012-12-01

    Full Text Available A spinal cord injury (SCI has a severe impact on human life in general as well as on the physical status and condition. The use of electrical signals to restore the function of paralyzed muscles is called functional electrical stimulation (FES. FES is a promising way to restore mobility to SCI by applying low-level electrical current to the paralyzed muscles so as to enhance that person’s ability to function and live independently. However, due to the limited number of commercially available FES assisted exerciser systems and their rather high cost, the conventional devices are unaffordable for most peoples. It is also inconvenient because of wired based system that creates a limitation in performing exercise. Thus, this project is concerned with the development of low-cost current controlled stimulator mainly for the paraplegic subjects. The developed device is based on a microcontroller, wireless based system using Zigbee module, voltage-to-current converter circuit and should produce proper monopolar and bipolar current pulses, pulse trains, arbitrary current waveforms, and a trigger output for FES applications. This device has been developed as in the new technique of the stimulator development with low cost and one of the contributing factors in Rehabilitation Engineering for patients with SCI.

  18. Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, Kevin L.; Ramuhalli, Pradeep; Brenchley, David L.; Coble, Jamie B.; Hashemian, Hash; Konnik, Robert; Ray, Sheila

    2012-09-14

    The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, U.S. Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineering Laboratory), NDE instrumentation development, universities, commercial NDE services and cable manufacturers, and Electric Power Research Institute (EPRI). The motivation for the R&D roadmap comes from the need to address the aging management of in-containment cables at nuclear power plants (NPPs).

  19. Analysis of current state and prospects of steel production development

    Science.gov (United States)

    Protopopov, E. V.; Feyler, S. V.

    2016-09-01

    Data on world production of steel in the XXI century are provided. Analysis of current state and prospects of ferrous metallurgy development in the Russian Federation is carried out. Results of national steel production performance during 10 months of the year 2015 are given for different countries. Analysis of the main directions of metallurgical equipment import substitution aimed at technological independence in the industry is made. Russian ferrous metallurgy development predictions in its’ main directions up to 2030 is provided.

  20. Current situation and development of solar heating technology in China

    Institute of Scientific and Technical Information of China (English)

    Zheng Ruicheng

    2009-01-01

    It is introduced the current situation and development for solar heating technology including passive solar heat-ing and solar heating combisystems in China in this paper. Combined with the engineering application projects, the au-thor gave the technical and economic analysis of the passive solar and solar heating combisystems in China and summa-rized the developing obstacle and the spreading tactics for raising marketing of the solar heating in China.

  1. Continuing Professional Development in School Psychology: Current Status.

    Science.gov (United States)

    Hynd, George W.; And Others

    1981-01-01

    Current patterns and trends in continuing education for school psychologists are identified by looking at the programs developed by the American Psychological Association and the National Association of School Psychologists, followed by a brief description of the National School Psychology Inservice Training Network project. (Author/BW)

  2. Online Current-Events Retrieval Services: Developments and Trends.

    Science.gov (United States)

    Smith, Stephen C.

    1984-01-01

    Summary of developments that have occurred in the past year in online news-retrieval services highlights the demise of the New York Times Information Service, Information Access Corporation's database additions and enhancements, full-text services, specialized databases with current events content, and microcomputer access to news. Twelve…

  3. Development of high current injector for tandem accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Baba, Takashi; Iwamoto, Eiji [Nissin - High Voltage Co. Ltd., Kyoto (Japan); Kishimoto, Naoki; Saito, Tetsuya; Mori, Yoshiharu

    1997-02-01

    The development of the electrostatic type tandem accelerators has been carried out so far, but by the recent remarkable progress of negative ion sources, the beam current which was inconceivable so far has become obtainable, and the use as the electrostatic type tandem accelerators is expanding rapidly. The problem which must be solved in the development of a high energy, large current heavy ion injection device is the development of an injector. As to the generation of negative ions, by the development of plasma sputter negative ion sources, the almost satisfactory performance has been obtained in beam current, emittance, life and so on, but as for the transport and control of generated negative ion beam, there is the large problem of spatial charge effect. This time, the verifying test on this problem was carried out, therefore, its contents and results are reported. The equipment which was developed this time was delivered to the Institute for Materials Research. Its specifications are shown. The whole constitution, negative ion source, and beam transport system are described. Beam generation test and spatial charge effect test are reported. The test stand was made, and in the verifying test, the maximum beams of 4 mA in Cu and 3 mA in Ni were able to be generated and transported. The effect of the countermeasures to spatial charge effect was confirmed. (K.I.)

  4. Considering digits in a current model of numerical development.

    Science.gov (United States)

    Roesch, Stephanie; Moeller, Korbinian

    2014-01-01

    Numerical cognition has long been considered the perfect example of abstract information processing. Nevertheless, there is accumulating evidence in recent years suggesting that the representation of number magnitude may not be entirely abstract but may present a specific case of embodied cognition rooted in the sensory and bodily experiences of early finger counting and calculating. However, so far none of the existing models of numerical development considers the influence of finger-based representations. Therefore, we make first suggestions on (i) how finger-based representations may be integrated into a current model of numerical development; and (ii) how they might corroborate the acquisition of basic numerical competencies at different development levels.

  5. Current trends in the development of laser glasses

    Energy Technology Data Exchange (ETDEWEB)

    Lunter, S.G.; Mit' kin, V.M.; Tolstoi, M.N.; Fedorov, IU.K.

    1988-02-01

    The principal requirements for glasses suitable for use in solid state lasers are briefly discussed, and some current trends in the development of thermally stable laser-grade phosphate glasses based on I-III elements are reviewed. In particular, attention is given to the optimization of glass composition with respect to structural strength and low brittleness; development of new methods for machining and protecting the side surfaces of active elements; development of new glasses with low concentration quenching, such as a lithium-neodymium-lanthanum-phosphate glass; new neodymium glasses with high chemical stability and low crystallizability; and methods for the dehydration of erbium phosphate glasses. 24 references.

  6. Current Development Situation and Prospects of Blueberry in Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    Lixia; GAO; Hualan; XIAO; Sen; LI; Fengmin; LIU; Aiqiong; MO

    2015-01-01

    With high nutrition and health value,blueberry receives much concern in recent years. Blueberry experts in the world are cultivating new blueberry varieties. They have come up with constructive theoretical support and planting technology researches and are constantly devoted to expanding blueberry planting latitudes. This paper elaborated researches of blueberry at home and abroad,current development situation of blueberry in China and Guangdong Province,analyzed strengths of planting blueberry in Guangdong. Besides,it came up with recommendations for development of blueberry industry. Finally,it discussed development prospects of blueberry planting in Guangdong.

  7. Currently developing opportunities in food irradiation and modern irradiation facilities

    Energy Technology Data Exchange (ETDEWEB)

    Wanke, R. [Director Business Development. SteriGenics International Inc. 17901 East Warren Avenue No. 4, Detroit, Michigan 48224-1333 (United States)

    1997-12-31

    I. Factor currently influencing advancing opportunities for food irradiation include: heightened incidence and awareness of food borne illnesses and causes. Concerns about ensuring food safety in international as well as domestic trade. Regulatory actions regarding commonly used fumigants/pesticides e.g. Me Br. II. Modern irradiator design: the SteriGenics {sup M}ini Cell{sup .} A new design for new opportunities. Faster installation of facility. Operationally and space efficient. Provides local {sup o}nsite control{sup .} Red meat: a currently developing opportunity. (Author)

  8. Investigation of inductively coupled ultrasonic transducer system for NDE.

    Science.gov (United States)

    Zhong, Cheng Huan; Croxford, Anthony J; Wilcox, Paul D

    2013-06-01

    Inductive coupling offers a simple solution to wirelessly probe ultrasonic transducers. This paper investigates the theory and feasibility of such an inductively coupled transducer system in the context of nondestructive evaluation (NDE) applications. The noncontact interface is based on electromagnetic coupling between three coils; one of the coils is physically connected to the transducer, the other two are in a separate probing unit, where they are connected to the transmit and receive channels of the instrumentation. The complete system is modeled as a three-port network with the measured impedance of a bonded piezoelectric ceramic disc representing a sensor attached to an arbitrary solid substrate. The developed transmission line model is a function of the physical parameters of the electromagnetic system, such as the number of turns and diameter of each coil, and their separation. This model provides immediate predictions of electrical input impedance and pulse-echo response. The model has been validated experimentally and a sensitivity analysis of the input parameters performed. This has enabled optimization of the various parameters. Inductively coupled transducer systems have been built for both bulk and guided wave examples. By using chirped excitation and baseline subtraction, inspection distance of up to 700 mm is achieved in single-shot, guided-wave pulse-echo mode measurements with a 5 mm separation between the probing coils and transducer coil on an aluminum plate structure. In the bulk wave example, a delamination in an 8.9-mm-thick carbon fiber composite specimen is successfully identified from the changes in the arrival time of a reflected pulse.

  9. Normalization and sound zone determination in pulse thermographic NDE

    Science.gov (United States)

    Sripragash, Letchuman; Sundaresan, Mannur

    2017-02-01

    Thermographic nondestructive evaluation is quick and effective in detecting damage particularly for composite structures. Pulse thermographic nondestructive evaluation (TNDE) technique can potentially provide information on defect dimensions, such as the depth at which the defect is located. However, there are a number of extraneous variables that affect the signal obtained during these tests, such as non-uniformity in the heat pulse applied and differences in the emissivity of the surfaces from specimen to specimen. In addition, the identification of defect free areas in the image is a challenge. As in other NDE procedures calibration specimens would be of help, but calibration specimens corresponding to complex damage states in composite materials are difficult to fabricate. Results from validated numerical simulations can complement calibration specimens. However, the thermo-mechanical properties of the test object as well as the amount of heat energy absorbed in the field tests are not readily available for such models. This paper presents an extension of the thermographic signal reconstruction (TSR) procedure in which the temperature and the time scales are respectively normalized with equilibrium temperature and the break time. A benefit of such normalization is the ability to directly measure the defect depth as a fraction of plate thickness. In order to implement this normalization procedure, sound zone profile definition is required. A new approach for determining sound zone profile has been developed. Finally, determination of sound zone is affected by non-uniform heating, and a method of minimizing the effects of non-uniform heating is proposed. The performance of these new approaches on actual experimental results are presented.

  10. Development of Peltier Current Lead for DC cable Hideo

    Science.gov (United States)

    Sugane; Hikichi, Yasuo; Minowa, Masahiro; Kawahara, Toshio; Watanabe, Hirofumi; Hamabe, Makoto; Yamaguchi, Sataro

    The widespread expectation is that superconducting technologies will be one of the effective technologies to decrease energy loss and improve efficiency in energy grids. Especially, in recent circumstances, applications connecting with renewable energy receive attention. Yamaguchi et al successfully developed 200 m-class superconducting direct current transmission and distribution system (CASER-2) in Chubu University and carried out the demonstration of this system. On this demonstration, "Peltier Current Lead (PCL)" was employed, wherein Peltier device was used for the purpose of pumping up the heat through the down-leads, It was observed that PCL reduced heat leak into cryostat as compared to usual Cu current leads on this demonstration, but some issues to be solved remained, such as heat-cycle performance etc.. In this paper, we designed a prototype PCL for the purpose of improvement of the mechanical strength and the durability for the heat cycle, and evaluated the performance.

  11. Preparing the NDE engineers of the future: Education, training, and diversity

    Science.gov (United States)

    Holland, Stephen D.

    2017-02-01

    As quantitative NDE has matured and entered the mainstream, it has created an industry need for engineers who can select, evaluate, and qualify NDE techniques to satisfy quantitative engineering requirements. NDE as a field is cross-disciplinary with major NDE techniques relying on a broad spectrum of physics disciplines including fluid mechanics, electromagnetics, mechanical waves, and high energy physics. An NDE engineer needs broad and deep understanding of the measurement physics across modalities, a general engineering background, and familiarity with shop-floor practices and tools. While there are a wide range of certification and training programs worldwide for NDE technicians, there are few programs aimed at engineers. At the same time, substantial demographic shifts are underway with many experienced NDE engineers and technicians nearing retirement, and with new generations coming from much more diverse backgrounds. There is a need for more and better education opportunities for NDE engineers. Both teaching and learning NDE engineering are inherently challenging because of the breadth and depth of knowledge required. At the same time, sustaining the field in a more diverse era will require broadening participation of previously underrepresented groups. The QNDE 2016 conference in Atlanta, GA included a session on NDE education, training, and diversity. This paper summarizes the outcomes and discussion from this session.

  12. The Development and Current State of Translation Process Research

    DEFF Research Database (Denmark)

    Lykke Jakobsen, Arnt

    2014-01-01

    The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer to a spe......The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer...... to a special descriptive, empirical, experimental approach to translation studies based on close, technology-supported observation of translational (micro)behaviour. Fundamentally, TPR is based on software which logs a translator’s keystrokes on a computer keyboard in time in combination with an eyetracker...

  13. Development of a current-controlled defibrillator for clinical tests.

    Science.gov (United States)

    Fischer, M; Schönegg, M; Schöchlin, J; Bolz, A

    2002-01-01

    The work presented here is only a part of the development for a new current-controlled defibrillator. In the diploma thesis "Development and construction of a current-controlled defibrillator for clinical tests" the most important part was the control and safety of the defibrillator. To ensure a safe circuit design, a risk-analysis and a Failure Mode and Effects Analysis (FMEA) were necessary. Another major part was the programming of a microcontroller in embedded C and a programmable logic device in Very High Speed Integrated Circuit Description Language (VHDL). The circuit had to be constructed, and the defibrillator was optically decoupled from the laptop for safety reasons. The waveform-data can be transmitted to the microcontroller from the laptop, and the logged data is then transmitted back.

  14. [Robotic colorectal surgery: current status and future developments].

    Science.gov (United States)

    Jayne, D

    2013-08-01

    Robotic assistance has the potential to compensate for the limitations inherent in standard laparoscopic surgery. The daVinci® surgical system remains the only currently available commercial robotic system. It has found popularity in rectal cancer surgery where its application has consistently been shown to reduce the need to convert to open surgery. With this exception, the technological advances of the robotic system have not so far translated into any reproducible patient benefit. The first part of this manuscript presents an overview of the current daVinci® platform, its applications, the evidence base and future developments in colorectal surgery. The second part of the manuscript looks at other robot systems in development and the different innovations and strategies taken to advance minimally invasive surgery.The English full-text version of this article is available at SpringerLink (under supplemental).

  15. Current development of saliva/oral fluid-based diagnostics.

    Science.gov (United States)

    Yeh, Chih-Ko; Christodoulides, Nicolaos J; Floriano, Pierre N; Miller, Craig S; Ebersole, Jeffrey L; Weigum, Shannon E; McDevitt, John; Redding, Spencer W

    2010-07-01

    Saliva can be easily obtained in medical and non-medical settings, and contains numerous bio-molecules, including those typically found in serum for disease detection and monitoring. In the past two decades, the achievements of high-throughput approaches afforded by biotechnology and nanotechnology allow for disease-specific salivary biomarker discovery and establishment of rapid, multiplex, and miniaturized analytical assays. These developments have dramatically advanced saliva-based diagnostics. In this review, we discuss the current consensus on development of saliva/oral fluid-based diagnostics and provide a summary of recent research advancements of the Texas-Kentucky Saliva Diagnostics Consortium. In the foreseeable future, current research on saliva based diagnostic methods could revolutionize health care.

  16. Current needs for further development of Serbian labour legislation

    Directory of Open Access Journals (Sweden)

    Jovanović Predrag

    2012-01-01

    Full Text Available Current needs for further development of Serbian legislation relate to the field of collective employee-employer relations and their collective rights and obligations. These are the relations established by the workers' and employers' mutually, but also the relationship between them, on the one hand and the state on the other. In other words, this is the need to strengthen the industrial democracies (including the improvement of labour legislation in the field of collective rights of employees and employers, which is actually still in stagnation. The fact is that trade union movement in Serbia, social dialogue, collective bargaining on working conditions, employees participation in management are weakening, which is where one should seek current needs for further development of labour law in order to strengthen and provide normatively the legal platform to stop these negative tendencies.

  17. Composite Materials NDE Using Enhanced Leaky Lamb Wave Dispersion Data Acquisition Method

    Science.gov (United States)

    Bar-Cohen, Yoseph; Mal, Ajit; Lih, Shyh-Shiuh; Chang, Zensheu

    1999-01-01

    The leaky Lamb wave (LLW) technique is approaching a maturity level that is making it an attractive quantitative NDE tool for composites and bonded joints. Since it was first observed in 1982, the phenomenon has been studied extensively, particularly in composite materials. The wave is induced by oblique insonification using a pitch-catch arrangement and the plate wave modes are detected by identifying minima in the reflected spectra to obtain the dispersion data. The wave behavior in multi-orientation laminates has been well documented and corroborated experimentally with high accuracy. The sensitivity of the wave to the elastic constants of the material and to the boundary conditions led to the capability to measure the elastic properties of bonded joints. Recently, the authors significantly enhanced the LLW method's capability by increasing the speed of the data acquisition, the number of modes that can be identified and the accuracy of the data inversion. In spite of the theoretical and experimental progress, methods that employ oblique insonification of composites are still not being applied as standard industrial NDE methods. The authors investigated the issues that are hampering the transition of the LLW to industrial applications and identified 4 key issues. The current capability of the method and the nature of these issues are described in this paper.

  18. Science communication in India: current situation, history and future developments

    OpenAIRE

    Mazzonetto Marzia

    2005-01-01

    Nowadays, India is experiencing a widespread diffusion of science communication activities. Public institutions, non-governmental organisations and a number of associations are busy spreading scientific knowledge not only via traditional media but also through specific forms of interaction with a varied public. This report aims to provide a historical overview of the diffusion of science communication in India, illustrating its current development and its future prospects.

  19. Current Application of Search Engines and Their Developing Trend

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li; SHAO Shi-huang; WU Xiao-qiong; ZENG Xian-hui; FAN Xiao-wen

    2002-01-01

    The basic types of current search engines which can help users to perfume laborious information-gathering tasks on Internet is proposed. Basically, the search engines can be classified into index engine, directory engine and agent engine on WWW information service. The key technologies of web mine, automatic classifying of documents and ordering regulation of feedback information are discussed. Finally, the developing trend of search engines is pointed out by analyzing their practical application on World Wide Web.

  20. Current Status and Development of National Grid in China

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    With most primary energy resources far from load centers, the voltage level of power system in China has imperatively been upgraded to meet the demand of long-distance power transmission. The successful commissioning of the 750-kV HVAC line in Northwest Power Grid has opened an era of national grid devel opment and brought about a series of technical problems to be faced. This report introduces briefly the current status and policies of UHV development in China.

  1. [The current state and development prospectives of military nephrology].

    Science.gov (United States)

    Nagibovich, O A; Golota, A S; Krassiĭ, A B

    2014-05-01

    This article is dedicated to the current state and prospectives of military nephrology. Using as examples the nephrology services of the armed forces of Serbia, France, Great Britain and USA it is shown that this branch of military healthcare plays an important role abroad. The brief review of military nephrology formation and development history demonstrates the growing significance of military nephrology in the general system of medical care at the battlefield.

  2. Review: New Vaccine Against Tuberculosis: Current Developments and Future Challenges

    Science.gov (United States)

    Liu, Jun

    2009-04-01

    Tuberculosis (TB) continues to be a global health threat. BCG was developed as an attenuated live vaccine for tuberculosis control nearly a century ago. Despite being the most widely used vaccine in human history, BCG is not an ideal vaccine and has two major limitations: its poor efficacy against adult pulmonary TB and its disconcerting safety in immunocompromised individuals. A safer and more effective TB vaccine is urgently needed. This review article discusses current strategies to develop the next generation of TB vaccines to replace BCG. While some progresses have been made in the past decade, significant challenges lie ahead.

  3. An eddy-current model for three-dimensional nondestructive evaluation of advanced composites

    Science.gov (United States)

    Sabbagh, Harold A.; Murphy, R. Kim; Sabbagh, Elias H.

    2015-03-01

    We have developed a rigorous electromagnetic model and an inversion algorithm for the three-dimensional NDE of advanced composite materials. This approach extends Victor Technologies' work in eddy-current NDE of conventional metals, and allows one to determine in localized regions the fiber-resin ratio in graphite-epoxy, and to determine those anomalies, e.g., delaminations, broken fibers, moisture content, etc., that can be reconstructed by our inversion method. In developing the model, we apply rigorous electromagnetic theory to determine a Green's function for a slab of anisotropic composite material, and then determine the integral relations for the forward and inverse problems using the Green's function. We will give examples of the solution of forward problems using this model.

  4. Lamb-Wave Embedded NDE with Piezoelectric Wafer Active Sensors for Structural Health Monitoring of Thin-Wall Structures

    Science.gov (United States)

    Giurgiutiu, Victor

    2004-02-01

    Piezoelectric wafer active sensors (PWAS) are inexpensive, non-intrusive, unobtrusive devices that can be surface-mounted on existing structures or inserted between the layers of new composite structures. The PWAS can be used in both active and passive modes. PWAS generate and detect Lamb waves and enable the development of embedded NDE concepts. This paper will present two embedded NDE concepts based on the PWAS technology and Lamb waves approach. The first concept utilizes traveling Lamb waves and could be described as embedded ultrasonics. It is shown that embedded PWAS are able to reproduce most of the conventional ultrasonic techniques, such as pitch-catch, pulse-echo, and phased array. Several experiments using Lamb waves traveling in thin-wall structures are presented.

  5. Durability Analysis and Experimental Validation of Environmental Barrier Coating (EBC Performance Using Combined Digital Image Correlation and NDE

    Directory of Open Access Journals (Sweden)

    Ali Abdul-Aziz

    2016-12-01

    Full Text Available To understand the failure mechanism or to predict the spallation life of environmental barrier coatings (EBC on fiber reinforced ceramic matrix composites, the fracture strength of EBC and the process of the crack growth in EBC layers need to be experimentally determined under standard or simulated engine operating conditions. The current work considers a multi layered barium strontium aluminum silicate (BSAS-based EBC-coated, melt infiltrated silicon carbide fiber reinforced silicon carbide matrix composite (MI SiC/SiC specimen that was tensile tested at room temperature. Numerous tests were performed under tensile loading conditions, and the specimen was loaded until failure under pre-determined stress levels. The specimen was examined with optical microscopy, scanning electron microscopy (SEM, computed tomography (CT scan, and digital image correlation (DIC camera. Observation from the computed tomography scanning, the SEM, and the optical microscopy did not offer conclusive information concerning the cracks that spawned during the tests. However, inspection with the DIC camera offered some indication that cracks had developed and allowed their detection and the location of their initiation site. Thus, this study provides detailed discussion of the results obtained from the experimental investigation and the nondestructive evaluation (NDE, and it also includes assessment of the stress response predicted by analytical modeling and their impact on EBC durability and crack growth formation under complex loading settings.

  6. Considering digits in a current model of numerical development

    Science.gov (United States)

    Roesch, Stephanie; Moeller, Korbinian

    2015-01-01

    Numerical cognition has long been considered the perfect example of abstract information processing. Nevertheless, there is accumulating evidence in recent years suggesting that the representation of number magnitude may not be entirely abstract but may present a specific case of embodied cognition rooted in the sensory and bodily experiences of early finger counting and calculating. However, so far none of the existing models of numerical development considers the influence of finger-based representations. Therefore, we make first suggestions on (i) how finger-based representations may be integrated into a current model of numerical development; and (ii) how they might corroborate the acquisition of basic numerical competencies at different development levels. PMID:25628559

  7. Fabry disease - current treatment and new drug development.

    Science.gov (United States)

    Motabar, Omid; Sidransky, Ellen; Goldin, Ehud; Zheng, Wei

    2010-07-23

    Fabry disease is a rare inherited lysosomal storage disorder caused by a partial or complete deficiency of α-galactosidase A (GLA), resulting in the storage of excess cellular glycosphingolipids. Enzyme replacement therapy is available for the treatment of Fabry disease, but it is a costly, intravenous treatment. Alternative therapeutic approaches, including small molecule chaperone therapy, are currently being explored. High throughput screening (HTS) technologies can be utilized to discover other small molecule compounds, including non-inhibitory chaperones, enzyme activators, molecules that reduce GLA substrate, and molecules that activate GLA gene promoters. This review outlines the current therapeutic approaches, emerging treatment strategies, and the process of drug discovery and development for Fabry disease.

  8. Benchmarking of Computational Models for NDE and SHM of Composites

    Science.gov (United States)

    Wheeler, Kevin; Leckey, Cara; Hafiychuk, Vasyl; Juarez, Peter; Timucin, Dogan; Schuet, Stefan; Hafiychuk, Halyna

    2016-01-01

    Ultrasonic wave phenomena constitute the leading physical mechanism for nondestructive evaluation (NDE) and structural health monitoring (SHM) of solid composite materials such as carbon-fiber-reinforced polymer (CFRP) laminates. Computational models of ultrasonic guided-wave excitation, propagation, scattering, and detection in quasi-isotropic laminates can be extremely valuable in designing practically realizable NDE and SHM hardware and software with desired accuracy, reliability, efficiency, and coverage. This paper presents comparisons of guided-wave simulations for CFRP composites implemented using three different simulation codes: two commercial finite-element analysis packages, COMSOL and ABAQUS, and a custom code implementing the Elastodynamic Finite Integration Technique (EFIT). Comparisons are also made to experimental laser Doppler vibrometry data and theoretical dispersion curves.

  9. Drugs in development for toxoplasmosis: advances, challenges, and current status

    Directory of Open Access Journals (Sweden)

    Alday PH

    2017-01-01

    Full Text Available P Holland Alday,1 Joseph Stone Doggett1,2 1Division of Infectious Diseases, Oregon Health & Science University, 2Portland Veterans Affairs Medical Center, Portland, OR, USA Abstract: Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are currently used to treat toxoplasmosis commonly have toxic side effects and require prolonged courses that range from weeks to more than a year. The need for long treatment durations and the risk of relapsing disease are in part due to the lack of efficacy against T. gondii tissue cysts. The challenges for developing a more effective treatment for toxoplasmosis include decreasing toxicity, achieving therapeutic concentrations in the brain and eye, shortening duration, eliminating tissue cysts from the host, safety in pregnancy, and creating a formulation that is inexpensive and practical for use in resource-poor areas of the world. Over the last decade, significant progress has been made in identifying and developing new compounds for the treatment of toxoplasmosis. Unlike clinically used medicines that were repurposed for toxoplasmosis, these compounds have been optimized for efficacy against toxoplasmosis during preclinical development. Medicines with enhanced efficacy as well as features that address the unique aspects of toxoplasmosis have the potential to greatly improve toxoplasmosis therapy. This review discusses the facets of toxoplasmosis that are pertinent to drug design and the advances, challenges, and current status of preclinical drug research for toxoplasmosis. Keywords: Toxoplasma gondii, therapeutics, preclinical medicine, experimental medicine, mechanism of action, Apicomplexa

  10. Drugs in development for toxoplasmosis: advances, challenges, and current status

    Science.gov (United States)

    Alday, P Holland; Doggett, Joseph Stone

    2017-01-01

    Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are currently used to treat toxoplasmosis commonly have toxic side effects and require prolonged courses that range from weeks to more than a year. The need for long treatment durations and the risk of relapsing disease are in part due to the lack of efficacy against T. gondii tissue cysts. The challenges for developing a more effective treatment for toxoplasmosis include decreasing toxicity, achieving therapeutic concentrations in the brain and eye, shortening duration, eliminating tissue cysts from the host, safety in pregnancy, and creating a formulation that is inexpensive and practical for use in resource-poor areas of the world. Over the last decade, significant progress has been made in identifying and developing new compounds for the treatment of toxoplasmosis. Unlike clinically used medicines that were repurposed for toxoplasmosis, these compounds have been optimized for efficacy against toxoplasmosis during preclinical development. Medicines with enhanced efficacy as well as features that address the unique aspects of toxoplasmosis have the potential to greatly improve toxoplasmosis therapy. This review discusses the facets of toxoplasmosis that are pertinent to drug design and the advances, challenges, and current status of preclinical drug research for toxoplasmosis. PMID:28182168

  11. Current trends of sugar consumption in developing societies.

    Science.gov (United States)

    Ismail, A I; Tanzer, J M; Dingle, J L

    1997-12-01

    This paper reviews recent data on sugar consumption in developing countries that may lead to a potential increase in caries prevalence. A search of the business, dental and nutritional literature was conducted through May 1995. There is evidence that sugar (sucrose) use was increasing in China, India, and Southeast Asia. In South and Central America (except Haiti) sugar use was either equivalent to or higher than that in most developed societies. In the Middle East, average sugar use was higher than that of other developing areas. However, it was either lower than or equivalent to the levels reported by other developed countries. Many central African countries consumed less than 15 kg of sugar/ person/year. Of particular concern is a rise in the consumption of sugar-containing carbonated beverages in a number of developing societies: China, India, Vietnam, Thailand, and other Southeast Asian countries are currently major growth markets for the soft drink industry. Consumption of high-sugar desserts and snacks may also be increasing in urban centers in some developing countries. To counteract the potential increase in the prevalence of dental caries in some developing countries, preventive and oral health promotion programs should be planned and implemented. We contend that taxation of sugar-containing products as well as efforts to reduce the level of sugar consumption to "safe" levels may be impractical, and in most countries, cannot be supported for political, economic, or health reasons. Instead, we recommend that collaboration be established between public health authorities and manufacturers/distributors of soft drinks and sweets in developing countries to establish a dental health fund that could be used to support caries preventive programs. The fund could be supported through donations from manufacturers based on the principle of the "milli-cent" (1 cent for every 1000 cents of sales). This minimal contribution would provide enough financial support for

  12. Development of RF linac for high-current applications

    Energy Technology Data Exchange (ETDEWEB)

    Chan, K.C.D.; Lawrence, G.P.; Schneider, J.D.

    1997-12-31

    High-current proton linacs are promising sources of neutrons for material processing and research applications. Recently, a linac design that makes use of a combination of normal-conducting (NC) and superconducting (SC) linac technologies has been proposed for the US Accelerator Production of Tritium Project. As a result, a multi-year engineering development and demonstration (ED and D) program is underway. In this paper, the authors will describe the design and merits of the NC/SC hybrid approach. The scope, technology issues, and present status of the ED and D Program, and the participation of industry will also be described.

  13. Directed Design of Experiments for Validating Probability of Detection Capability of NDE Systems (DOEPOD)

    Science.gov (United States)

    Generazio, Edward R.

    2015-01-01

    Directed Design of Experiments for Validating Probability of Detection Capability of NDE Systems (DOEPOD) Manual v.1.2 The capability of an inspection system is established by applications of various methodologies to determine the probability of detection (POD). One accepted metric of an adequate inspection system is that there is 95% confidence that the POD is greater than 90% (90/95 POD). Design of experiments for validating probability of detection capability of nondestructive evaluation (NDE) systems (DOEPOD) is a methodology that is implemented via software to serve as a diagnostic tool providing detailed analysis of POD test data, guidance on establishing data distribution requirements, and resolving test issues. DOEPOD demands utilization of observance of occurrences. The DOEPOD capability has been developed to provide an efficient and accurate methodology that yields observed POD and confidence bounds for both Hit-Miss or signal amplitude testing. DOEPOD does not assume prescribed POD logarithmic or similar functions with assumed adequacy over a wide range of flaw sizes and inspection system technologies, so that multi-parameter curve fitting or model optimization approaches to generate a POD curve are not required. DOEPOD applications for supporting inspector qualifications is included.

  14. State of the Art Assessment of NDE Techniques for Aging Cable Management in Nuclear Power Plants FY2015

    Energy Technology Data Exchange (ETDEWEB)

    Glass, Samuel W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fifield, Leonard S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dib, Gerges [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tedeschi, Jonathan R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Jones, Anthony M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hartman, Trenton S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-09-08

    This milestone report presents an update on the state-of-the-art review and research being conducted to identify key indicators of in-containment cable aging at nuclear power plants (NPPs), and devise in-situ measurement techniques that are sensitive to these key indicators. The motivation for this study stems from the need to address open questions related to nondestructive evaluation (NDE) of aging cables for degradation detection and estimation of condition-based remaining service life. These questions arise within the context of a second round of license extension for NPPs that would extend the operating license to 60 and 80 years. Within the introduction, a review of recently published U.S. and international research and guidance for cable aging management programs including NDE technologies is provided. As with any “state-of-the-art” report, the observations are deemed accurate as of the publication date but cannot anticipate evolution of the technology. Moreover, readers are advised that research and development of cable NDE technology is an ongoing issue of global concern.

  15. Current status of outcome measure development in vasculitis.

    Science.gov (United States)

    Merkel, Peter A; Aydin, Sibel Z; Boers, Maarten; Cornell, Christina; Direskeneli, Haner; Gebhart, Don; Hatemi, Gulen; Luqmani, Raashid; Matteson, Eric L; Milman, Nataliya; Robson, Joanna; Seo, Philip; Tomasson, Gunnar

    2014-03-01

    The conduct of randomized controlled trials for vasculitis, especially for the antineutrophil cytoplasmic antibody-associated vasculitides [AAV, granulomatosis with polyangiitis (Wegener's) and microscopic polyangiitis], has been greatly advanced by the development, use, and acceptance of validated outcome measures. Trials have subsequently provided the opportunity to validate and refine reliable, valid outcome measures for these multisystemic and relapsing rare diseases. The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group was formed in 2004 to foster development of validated and widely accepted outcomes in vasculitis using data-driven analyses, a dedication to building consensus, and adherence to, and guidance by, the principles of the OMERACT approach. This work led to the endorsement by OMERACT of the core set of domains and associated outcome measures for AAV. Next steps for the study of existing outcome tools in AAV include better definition of response criteria through development of more data-driven weighting of the elements of activity and damage assessment. The Working Group is now also embarking on a series of linked projects to develop validated patient-reported outcomes for use in clinical research in vasculitis. Additionally, the Working Group is studying how current methods of disease assessment and plans for new outcomes can be informed by the conceptual framework of the International Classification of Function of the World Health Organization. The success of the Group's work in AAV has also led to a formal process for developing outcomes for the large vessel vasculitides (Takayasu arteritis and giant cell arteritis) and Behçet disease.

  16. A geomagnetically induced current warning system: model development and validation

    Science.gov (United States)

    McKay, A.; Clarke, E.; Reay, S.; Thomson, A.

    Geomagnetically Induced Currents (GIC), which can flow in technological systems at the Earth's surface, are a consequence of magnetic storms and Space Weather. A well-documented practical problem for the power transmission industry is that GIC can affect the lifetime and performance of transformers within the power grid. Operational mitigation is widely considered to be one of the best strategies to manage the Space Weather and GIC risk. Therefore in the UK a magnetic storm warning and GIC monitoring and analysis programme has been under development by the British Geological Survey and Scottish Power plc (the power grid operator for Central Scotland) since 1999. Under the auspices of the European Space Agency's service development activities BGS is developing the capability to meet two key user needs that have been identified. These needs are, firstly, the development of a near real-time solar wind shock/ geomagnetic storm warning, based on L1 solar wind data and, secondly, the development of an integrated surface geo-electric field and power grid network model that should allow prediction of GIC throughout the power grid in near real time. While the final goal is a `seamless package', the components of the package utilise diverse scientific techniques. We review progress to date with particular regard to the validation of the individual components of the package. The Scottish power grid response to the October 2003 magnetic storms is also discussed and model and validation data are presented.

  17. The current state of industry development in Ukraine: advance perspective

    Directory of Open Access Journals (Sweden)

    Skyba Maryna Valeriyivna

    2015-02-01

    Full Text Available The current state of the industry of Ukraine are considered at the article. The author determined that the stabilization of the situation and further development of the industry need first of all cessation of hostilities. It is necessary to implement effective measures to combat corruption, the development of consistent, constructive and concerted action on the formation of institutions guaranteeing stability, predictability and transparency of the market rules and procedures that minimize the impact of shadow factors, and implementation of professional privatization and limitation of monopoly at the markets, forming a transparent, competitive business environment, the introduction of new energy saving technologies. These measures will help attract investment, increase production and improve enterprise profitability.

  18. Social Pedagogy in North America: historical background and current developments

    Directory of Open Access Journals (Sweden)

    Daniel Schugurensky

    2015-12-01

    Full Text Available In North America, the use of the term ‘social pedagogy’ is a relatively new phenomenon, but social pedagogical practices have been used for a long time. The recent interest in the field of social pedagogy can be explained in part by the publication of an unprecedented volume of books and articles in English language, the creation of a new international journal, the simultaneous development of graduate programs in social pedagogy in the UK and the USA, and the establishment of a social pedagogy association that brings together academics and practitioners. In North America, social pedagogy thinking is influenced by the history of the field, by current social pedagogy theory and practice in other parts of the world, and by several traditions that connect education with social change. The paper discusses ten of them: indigenous education, progressive education, social movement learning, community development, public pedagogy, popular education, participatory action research, social economy, participatory democracy, and critical theory. 

  19. Evolution and current development of Transversal Themes: possibilities and limits

    Directory of Open Access Journals (Sweden)

    Carlos Rosales López

    2015-02-01

    Full Text Available The aim of this study was to determine the characteristics of the evolution and current development of transversal themes in education, considering them basically as important social cuestions with great influence in the overall education of the student. Specifically it seeks to clarify the level of preparation and dedication of teachers and schools to teach them. To do this, legislation used in our country (organics laws and decrees curriculum were analyzed and also the contribution of outstanding educators, institutions and researchers. We analyzed the characteristics of transversal themes in the educational project and the teaching program, its development in the clasroom and its projection out of it through the help of family and community. Conclusions about their current status (possibilities and limitations are derived and future proposals are made on the improvement of initial and ongoing training of teachers, to increase their collegiate or cooperative work of planning, intervention and evaluation, increased media and counseling in use, the need for increased communication and collaboration with families and other community institutions.How to reference this articleRosales López, C. (2015. Evolución y desarrollo actual de los Temas Transversales: posibilidades y límites. Foro de Educación, 13(18, pp. 143-160. doi: http://dx.doi.org/10.14516/fde.2015.013.018.008

  20. NDE for the 21st century: industry 4.0 requires NDE 4.0 (Conference Presentation)

    Science.gov (United States)

    Meyendorf, Norbert G.

    2017-04-01

    Industry 4.0 stands for the fourth industrial revolution that is ongoing at present. Industry 4.0 is a terminology preferred used in Europe to characterize the integration of production and communication technologies, the so called "smart factory". The first industrial revolution was the mechanization of work. The second was mass production and the assembly line. While the third revolution was the computer integrated manufacturing. Industry 4.0 encompasses the complete networking of all industrial areas. Lowering costs and efficient in-time production will be possible also for low numbers of very unique parts for example by additive manufacturing (3D printing). A significant aspect is also quality and maintainability of these sometimes unique structures and components. NDE has to follow these trends, not only by adapting NDE techniques to the new technologies, but also introducing the capability of cyber systems into the inspection and maintenance processes. The requirements and challenges for this new technological area will be discussed. Chances for applications of new technologies and systems for NDE will be demonstrated online.

  1. Rock grouting. Current competence and development for the final repository

    Energy Technology Data Exchange (ETDEWEB)

    Emmelin, Ann (Swedish Nuclear Fuel and Waste Management Co., Stockholm (SE)); Brantberger, Martin (Ramboell (SE)); Eriksson, Magnus (Vattenfall Power Consultant (SE)); Gustafson, Gunnar (Chalmers Univ. of Technology, Goeteborg (SE)); Stille, Haakan (Royal Inst. of Technology, Stockholm (SE))

    2007-06-15

    The report aims at presenting the overall state of grouting competence and development relating to the final repository and at motivating and giving detail to the grouting sections presented in the 2007 version of the overall SKB report 'Programme for research, development and demonstration of methods for the management and disposal of nuclear waste' that is presented to the government every three years. The report offers suggestions for principles for planning, design and execution of grouting and describes the further work thought to be necessary in order to meet the requirements of the final repository, that are currently given as working premises. This report does not aim to, and cannot, describe the grouting processes in detail. For details of current concepts, experience and development work, a list of references is provided. In Chapter 2, the task of sealing the underground repository is examined and an overall approach presented. Although the requirements related to this task are preliminary, it is made evident that they concern both the actual grouting results and the process leading to the achievement of these results. Chapter 3 is a conceptual description of grouting and the factors that govern the spreading of grout in the rock mass. It is intended as an introduction to Chapters 4-6, which describe the state of grouting competence and the tools available for the sealing of the final repository facility. Both common practice and cutting-edge research are dealt with in these chapters, mainly relying on references where available. Chapters 4 and 5 focus on the system consisting of the fundamental components the rock mass, the grout materials and the grouting technology, and how these system components interact whilst, in Chapter 6, the rock/grout technical system is viewed in a brief organizational context. Based on the requirements on results and the overall grouting process on the one hand and the current competence in grouting theory and

  2. Time-Domain Terahertz Computed Axial Tomography NDE System

    Science.gov (United States)

    Zimdars, David

    2012-01-01

    NASA has identified the need for advanced non-destructive evaluation (NDE) methods to characterize aging and durability in aircraft materials to improve the safety of the nation's airline fleet. 3D THz tomography can play a major role in detection and characterization of flaws and degradation in aircraft materials, including Kevlar-based composites and Kevlar and Zylon fabric covers for soft-shell fan containment where aging and durability issues are critical. A prototype computed tomography (CT) time-domain (TD) THz imaging system has been used to generate 3D images of several test objects including a TUFI tile (a thermal protection system tile used on the Space Shuttle and possibly the Orion or similar capsules). This TUFI tile had simulated impact damage that was located and the depth of damage determined. The CT motion control gan try was designed and constructed, and then integrated with a T-Ray 4000 control unit and motion controller to create a complete CT TD-THz imaging system prototype. A data collection software script was developed that takes multiple z-axis slices in sequence and saves the data for batch processing. The data collection software was integrated with the ability to batch process the slice data with the CT TD-THz image reconstruction software. The time required to take a single CT slice was decreased from six minutes to approximately one minute by replacing the 320 ps, 100-Hz waveform acquisition system with an 80 ps, 1,000-Hz waveform acquisition system. The TD-THZ computed tomography system was built from pre-existing commercial off-the-shelf subsystems. A CT motion control gantry was constructed from COTS components that can handle larger samples. The motion control gantry allows inspection of sample sizes of up to approximately one cubic foot (.0.03 cubic meters). The system reduced to practice a CT-TDTHz system incorporating a COTS 80- ps/l-kHz waveform scanner. The incorporation of this scanner in the system allows acquisition of 3D

  3. Shigella vaccine development: prospective animal models and current status.

    Science.gov (United States)

    Kim, Yeon-Jeong; Yeo, Sang-Gu; Park, Jae-Hak; Ko, Hyun-Jeong

    2013-01-01

    Shigella was first discovered in 1897 and is a major causative agent of dysenteric diarrhea. The number of affected patients has decreased globally because of improved sanitary conditions; however, Shigella still causes serious problems in many subjects, including young children and the elderly, especially in developing countries. Although antibiotics may be effective, a vaccine would be the most powerful solution to combat shigellosis because of the emergence of drug-resistant strains. However, the development of a vaccine is hampered by several problems. First, there is no suitable animal model that can replace human-based studies for the investigation of the in vivo mechanisms of Shigella vaccines. Mouse, guinea pig, rat, rabbit, and nonhuman primates could be used as models for shigellosis, but they do not represent human shigellosis and each has its own weaknesses. However, a recent murine model based on peritoneal infection with virulent S. flexneri 2a is promising. Moreover, although the inflammatory responses and mechanisms such as pathogenassociated molecular patterns and danger-associated molecular patterns have been studied, the pathology and immunology of Shigella are still not clearly defined. Despite these obstacles, many vaccine candidates have been developed, including live attenuated, killed whole cells, conjugated, and subunit vaccines. The development of Shigella vaccines also demands considerations of the cost, routes of administration, ease of storage (stability), cross-reactivity, safety, and immunogenicity. The main aim of this review is to provide a detailed introduction to the many promising vaccine candidates and animal models currently available, including the newly developed mouse model.

  4. Current trends and future directions in flower development research.

    Science.gov (United States)

    Scutt, Charlie P; Vandenbussche, Michiel

    2014-11-01

    Flowers, the reproductive structures of the approximately 400 000 extant species of flowering plants, exist in a tremendous range of forms and sizes, mainly due to developmental differences involving the number, arrangement, size and form of the floral organs of which they consist. However, this tremendous diversity is underpinned by a surprisingly robust basic floral structure in which a central group of carpels forms on an axis of determinate growth, almost invariably surrounded by two successive zones containing stamens and perianth organs, respectively. Over the last 25 years, remarkable progress has been achieved in describing the molecular mechanisms that control almost all aspects of flower development, from the phase change that initiates flowering to the final production of fruits and seeds. However, this work has been performed almost exclusively in a small number of eudicot model species, chief among which is Arabidopsis thaliana. Studies of flower development must now be extended to a much wider phylogenetic range of flowering plants and, indeed, to their closest living relatives, the gymnosperms. Studies of further, more wide-ranging models should provide insights that, for various reasons, cannot be obtained by studying the major existing models alone. The use of further models should also help to explain how the first flowering plants evolved from an unknown, although presumably gymnosperm-like ancestor, and rapidly diversified to become the largest major plant group and to dominate the terrestrial flora. The benefits for society of a thorough understanding of flower development are self-evident, as human life depends to a large extent on flowering plants and on the fruits and seeds they produce. In this preface to the Special Issue, we introduce eleven articles on flower development, representing work in both established and further models, including gymnosperms. We also present some of our own views on current trends and future directions of the

  5. Anti-Influenza Treatment: Drugs Currently Used and Under Development.

    Science.gov (United States)

    Amarelle, Luciano; Lecuona, Emilia; Sznajder, Jacob I

    2017-01-01

    Influenza is a very common contagious disease that carries significant morbidity and mortality. Treatment with antiviral drugs is available, which if administered early, can reduce the risk of severe complications. However, many virus types develop resistance to those drugs, leading to a notable loss of efficacy. There has been great interest in the development of new drugs to combat this disease. A wide range of drugs has shown anti-influenza activity, but they are not yet available for use in the clinic. Many of these target viral components, which others are aimed at elements in the host cell which participate in the viral cycle. Modulating host components is a strategy which minimizes the development of resistance, since host components are not subject to the genetic variability of the virus. The main disadvantage is the risk of treatment-related side effects. The aim of this review is to describe the main pharmacological agents currently available and new drugs in the pipeline with potential benefit in the treatment of influenza. Copyright © 2016 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.

  6. Current situation and development of wind power in China

    Institute of Scientific and Technical Information of China (English)

    BAO Nengsheng; NI Weidou

    2007-01-01

    The current development of wind power in China was presented in this paper.Many regions such as Xinjiang Uygur Autonomous Region,Inner Mongolia Autonomous Region and southeast coastal region,etc.in China have abundant wind energy resource.At the same time,the utilization of wind power in China has been developing quickly and its prospect is promising in spite of many some obstacles.With the implementation of the Renewable Energy Law,some previous obstacles have been or are being eliminated.Much investment and many enterprises start to enter this field.In spite of this,there still exist some financial and technological obstacles.One of the technological obstacles is the stability of local power grid owing to the increasing proportion of the wind power capacity.Because the centralized development mode of wind power was adopted,the quick fluctuation of wind speed will influence the voltage and frequency stability of local power grid.In addition,large wind farm has little dispatching ability because of the uncontrollability,randomness and fluctuation of natural incoming wind.To erase these obstacles,a novel hybrid power system combining wind farm and small gas turbine power plants is discussed.

  7. Diagnosis of Helicobacter pylori infection: Current options and developments

    Science.gov (United States)

    Wang, Yao-Kuang; Kuo, Fu-Chen; Liu, Chung-Jung; Wu, Meng-Chieh; Shih, Hsiang-Yao; Wang, Sophie SW; Wu, Jeng-Yih; Kuo, Chao-Hung; Huang, Yao-Kang; Wu, Deng-Chyang

    2015-01-01

    Accurate diagnosis of Helicobacter pylori (H. pylori) infection is a crucial part in the effective management of many gastroduodenal diseases. Several invasive and non-invasive diagnostic tests are available for the detection of H. pylori and each test has its usefulness and limitations in different clinical situations. Although none can be considered as a single gold standard in clinical practice, several techniques have been developed to give the more reliable results. Invasive tests are performed via endoscopic biopsy specimens and these tests include histology, culture, rapid urease test as well as molecular methods. Developments of endoscopic equipment also contribute to the real-time diagnosis of H. pylori during endoscopy. Urea breathing test and stool antigen test are most widely used non-invasive tests, whereas serology is useful in screening and epidemiological studies. Molecular methods have been used in variable specimens other than gastric mucosa. More than detection of H. pylori infection, several tests are introduced into the evaluation of virulence factors and antibiotic sensitivity of H. pylori, as well as screening precancerous lesions and gastric cancer. The aim of this article is to review the current options and novel developments of diagnostic tests and their applications in different clinical conditions or for specific purposes. PMID:26523098

  8. Current Situations and Countermeasures of Organic Tobacco Development

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Current situations of organic tobacco development at both home and abroad,indicating that organic tobacco is one of the innovation directions for sustainable,healthy,environmental protection and low carbon development of modern tobacco industry.On the basis of foreign cultivation technical system for organic agriculture,the cultivation technical system for organic tobacco is summed up as follows:first,keep the diversity and continuity of space and time;second,ensure closeness of nutrient cycle;third,improve self-regulatory system and protection ability of crops.Then,the development trend of organic tobacco is analyzed and corresponding measures are put forward:establish production base and assessment system for organic tobacco;establish technical system for production of organic tobacco;establish and perfect evaluation system for management,production and supervision of organic tobacco;strengthen popularization of production and concept of organic tobacco;improve management of organic tobacco purchase,industry commerce handover,and redrying.

  9. Vocational Literacy in Mozambique: Historical Development, Current Challenges and Contradictions

    Directory of Open Access Journals (Sweden)

    Oleg Popov

    2016-03-01

    Full Text Available The study analyses the historical development of vocational literacy in basic education and Non-Formal Vocational Education (NFVE in Mozambique, as well as current challenges and contradictions. The theoretical lens of Cultural-Historical Activity Theory (CHAT is employed in the study. Methodologically the study was executed through an analysis of oral, printed and e-resources produced by the main stakeholders and also the reflective experiences of the authors in their extensive educational work in the country. The findings reveal poorly developed vocational literacy education in schools and non-formal settings in spite of recurrent political declarations about its importance. There is a strong dependence by formal and particularly NFVE sectors on the technical and financial support provided by international organisations. Vocational literacy courses are characterized by a lack of adequate equipment and poor practice. As a consequence, theoretical or elementary forms of vocational knowledge are dominant in the courses, resulting in the dissatisfaction of both learners and educators. Vocational literacy development proved to be a complex field that faces many challenges and ischaracterised by diverse internal contradictions.

  10. Diagnosis of Helicobacter pylori infection: Current options and developments.

    Science.gov (United States)

    Wang, Yao-Kuang; Kuo, Fu-Chen; Liu, Chung-Jung; Wu, Meng-Chieh; Shih, Hsiang-Yao; Wang, Sophie S W; Wu, Jeng-Yih; Kuo, Chao-Hung; Huang, Yao-Kang; Wu, Deng-Chyang

    2015-10-28

    Accurate diagnosis of Helicobacter pylori (H. pylori) infection is a crucial part in the effective management of many gastroduodenal diseases. Several invasive and non-invasive diagnostic tests are available for the detection of H. pylori and each test has its usefulness and limitations in different clinical situations. Although none can be considered as a single gold standard in clinical practice, several techniques have been developed to give the more reliable results. Invasive tests are performed via endoscopic biopsy specimens and these tests include histology, culture, rapid urease test as well as molecular methods. Developments of endoscopic equipment also contribute to the real-time diagnosis of H. pylori during endoscopy. Urea breathing test and stool antigen test are most widely used non-invasive tests, whereas serology is useful in screening and epidemiological studies. Molecular methods have been used in variable specimens other than gastric mucosa. More than detection of H. pylori infection, several tests are introduced into the evaluation of virulence factors and antibiotic sensitivity of H. pylori, as well as screening precancerous lesions and gastric cancer. The aim of this article is to review the current options and novel developments of diagnostic tests and their applications in different clinical conditions or for specific purposes.

  11. Ebola hemorrhagic Fever and the current state of vaccine development.

    Science.gov (United States)

    Hong, Joo Eun; Hong, Kee-Jong; Choi, Woo Young; Lee, Won-Ja; Choi, Yeon Hwa; Jeong, Chung-Hyeon; Cho, Kwang-Il

    2014-12-01

    Current Ebola virus outbreak in West Africa already reached the total number of 1,323 including 729 deaths by July 31st. the fatality is around 55% in the southeastern area of Guinea, Sierra Leone, Liberia, and Nigeria. The number of patients with Ebola Hemorrhagic Fever (EHF) was continuously increasing even though the any effective therapeutics or vaccines has not been developed yet. The Ebola virus in Guinea showed 98% homology with Zaire Ebola Virus. Study of the pathogenesis of Ebola virus infection and assess of the various candidates of vaccine have been tried for a long time, especially in United States and some European countries. Even though the attenuated live vaccine and DNA vaccine containing Ebola viral genes were tested and showed efficacy in chimpanzees, those candidates still need clinical tests requiring much longer time than the preclinical development to be approved for the practical treatment. It can be expected to eradicate Ebola virus by a safe and efficient vaccine development similar to the case of smallpox virus which was extinguished from the world by the variola vaccine.

  12. Development and implementation of a rail current optimization program

    Energy Technology Data Exchange (ETDEWEB)

    King, T.L.; Dharamshi, R. [Univ. of Houston, TX (United States). Dept. of Electrical and Computer Engineering; Kim, K.; Zhang, J.; Tompkins, M.W.; Anderson, M.A.; Feng, Q. [Univ. of Illinois, Urbana, IL (United States). Dept. of Electrical and Computer Engineering

    1997-01-01

    Efforts are underway to automate the operation of a railgun hydrogen pellet injector for fusion reactor refueling. A plasma armature is employed to avoid the friction produced by a sliding metal armature and, in particular, to prevent high-Z impurities from entering the tokamak. High currents are used to achieve high accelerations, resulting in high plasma temperatures. Consequently, the plasma armature ablates and accumulates material from the pellet and gun barrel. This increases inertial and viscous drag, lowering acceleration. A railgun model has been developed to compute the acceleration in the presence of these losses. In order to quantify these losses, the ablation coefficient, {alpha}, and drag coefficient, C{sub d}, must be determined. These coefficients are estimated based on the pellet acceleration. The sensitivity of acceleration to {alpha} and C{sub d} has been calculated using the model. Once {alpha} and C{sub d} have been determined, their values are applied to the model to compute the appropriate current pulse width. An optimization program was written in LabVIEW software to carry out this procedure. This program was then integrated into the existing code used to operate the railgun system. Preliminary results obtained after test firing the gun indicate that the program computes reasonable values for {alpha} and C{sub d} and calculates realistic pulse widths.

  13. The IASB and FASB Convergence Process: Current Developments

    Directory of Open Access Journals (Sweden)

    Saher Aqel

    2012-04-01

    Full Text Available The importance of harmonization of accounting atandards is now widely accepted all over the world. The increased international movement of investments has strongly forces the harmonization of the various national accounting standards in a uniform financial reporting system accepted worldwide. Recently the Securities and Exchange Commission has agreed to remove the requirement international firms reporting under International Financial Reporting Standards (IFRS and listed in the U.S to provide reconciliation to U.S. Generally Accepted Accounting Principles (GAAP. This recent move of the Securities and Exchange Commission indicate that U.S. financial reporting is likely to converge with IFRS in the near future. The International Accounting Standards Board (IASB and the Financial Accounting Standards Board (FASB are currently working together so as to converge their existing accounting standards into a common set of international accounting standards. The objective of this paper is to discuss the FASB and IASB convergence process by addressing current developments regarding significant topics that were deemed critical to this convergence. The convergence of GAAP and IFRS seems inevitable. Mixed opinions have been voiced about this convergence process. Many have begun to consider obstacles that is possible to lay ahead as well as the possible costs and benefits of such a move to the IFRS .

  14. Recent advancements in the electromechanical (E/M) impedance method for structural health monitoring and NDE

    Science.gov (United States)

    Giurgiutiu, Victor; Rogers, Craig A.

    1998-07-01

    The emerging electro-mechanical impedance technology has high potential for in-situ health monitoring and NDE of structural systems and complex machinery. At first, the fundamental principles of the electro-mechanical impedance method are briefly reviewed and ways for practical implementation are highlighted. The equations of piezo- electric material response are given, and the coupled electro-mechanical impedance of a piezo-electric wafer transducer as affixed to the monitored structure is discussed. Due to the high frequency operation of this NDE method, wave propagation phenomena are identified as the primary coupling method between the structural substrate and the piezo-electric wafer transducer. Attention is then focused on several recent advancements that have extended the electro-mechanical impedance method into new areas of applications and/or have developed its underlying principles. US Army Construction Engineering Research Laboratory used the electro-mechanical impedance method to monitor damage development in composite overlaid civil infrastructure specimens under full-scale static testing. A simplified E/M impedance measuring technique was employed at the Polytechnic University of Madrid, Spain, to detect damage in GFRP composite specimens. The development of miniaturized `bare-bones' impedance analyzer equipment that could be easily packaged into transponder-size dimensions is being studied at the University of South Carolina. US Army Research Laboratory developed novel piezo-composite film transducers for embedment into composite structures. Disbond gauges for monitoring the structural joints of adhesively bonded rotor blades have been studies in the Mechanical Engineering Department at the University of South Carolina. These recent developments accentuate the importance and benefits of using the electro-mechanical impedance method for on-line health monitoring and damage detection in a variety of applications. Further investigation of the electro

  15. Development of high temperature superconductors having high critical current density

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Gye Wong; Kim, C. J.; Lee, H.G.; Kwon, S. C.; Lee, H. J.; Kim, K. B.; Park, J. Y.; Jung, C. H

    2000-08-01

    Fabrication of high T{sub c} superconductors and its applications for electric power device were carried out for developing superconductor application technologies. High quality YBCO superconductors was fabricated by melt texture growth, top-seeded melt growth process and multi-seeded melt growth process and the properties was compared. The critical current density of the melt processed YBCO superconductors was about few 10,000 A/cm{sup 2} and the levitation force was 50 N. The processing time needed for the growth of the 123 single grain was greatly reduced by applying multi-seeding without no significant degradation of the levitation force. The multi-seeded melt growth process was confirmed as a time-saving and cost-effective method for the fabrication of bulk superconductors with controlled crystallographic orientation.

  16. Current developments in pharmacological therapeutics for chronic constipation

    Directory of Open Access Journals (Sweden)

    Chunhuan Jiang

    2015-07-01

    Full Text Available Chronic constipation is a common gastrointestinal disease severely affecting the patient׳s quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT4 receptor modulators velusetrag and naronapride, the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field.

  17. Immunotherapy and lung cancer: current developments and novel targeted therapies.

    Science.gov (United States)

    Domingues, Duarte; Turner, Alice; Silva, Maria Dília; Marques, Dânia Sofia; Mellidez, Juan Carlos; Wannesson, Luciano; Mountzios, Giannis; de Mello, Ramon Andrade

    2014-01-01

    Non-small-cell lung cancer (NSCLC) is a highly prevalent and aggressive disease. In the metastatic setting, major advances include the incorporation of immunotherapy and targeted therapies into the clinician's therapeutic armamentarium. Standard chemotherapeutic regimens have long been reported to interfere with the immune response to the tumor; conversely, antitumor immunity may add to the effects of those therapies. The aim of immunotherapy is to specifically enhance the immune response directed to the tumor. Recently, many trials addressed the role of such therapies for metastatic NSCLC treatment: ipilimumab, tremelimumab, nivolumab and lambrolizumab are immunotherapeutic agents of main interest in this field. In addition, anti-tumor vaccines, such as MAGE-A3, Tecetomide, TG4010, CIMAvax, ganglioside vaccines, tumor cell vaccines and dendritic cell vaccines, emerged as potent inducers of immune response against the tumor. The current work aims to address the most recent developments regarding these innovative immunotherapies and their implementation in the treatment of metastatic NSCLC.

  18. Bulk Glassy Alloys: Historical Development and Current Research

    Directory of Open Access Journals (Sweden)

    Akihisa Inoue

    2015-06-01

    Full Text Available This paper reviews the development of current research in bulk glassy alloys by focusing on the trigger point for the synthesis of the first bulk glassy alloys by the conventional mold casting method. This review covers the background, discovery, characteristics, and applications of bulk glassy alloys, as well as recent topics regarding them. Applications of bulk glassy alloys have been expanding, particularly for Fe-based bulk glassy alloys, due to their unique properties, high glass-forming ability, and low cost. In the near future, the engineering importance of bulk glassy alloys is expected to increase steadily, and continuous interest in these novel metallic materials for basic science research is anticipated.

  19. Development of high current beam ns pulsed system

    CERN Document Server

    Shen Guan Ren; Gao Fu; Guan Xia Ling; LiuNaiYi

    2001-01-01

    The development of high current beam ns pulsed system of CPNG and its characteristic, main technological performance and application are introduced. Firstly, important parameters of the system are calculated using theoretical model, the design requirements of some important parts are understood. Some mistakes in physics conception are corrected. Second, the chopper is designed for parallel plate deflector, chopping aperture and sine wave voltage sweeping device. It is emphasized that the conception of parallel plate load impedance is the capacitance load, but not the 50 ohm load impedance. The dynamic capacitance value has been measured. The output emphasizes the output voltage amplitude, but not the output power for sweeping device. The display system of output sweeping voltage was set up and it is sure that the maximum output voltage(V-V) is >=4000 V. The klystron buncher are re-designed. It is emphasized to overcome difficulty of support high voltage electrode in the klystron and insulator of input sine wa...

  20. Robotic technology in spine surgery: current applications and future developments.

    Science.gov (United States)

    Stüer, Carsten; Ringel, Florian; Stoffel, Michael; Reinke, Andreas; Behr, Michael; Meyer, Bernhard

    2011-01-01

    Medical robotics incrementally appears compelling in nowadays surgical work. The research regarding an ideal interaction between physician and computer assistance has reached a first summit with the implementation of commercially available robots (Intuitive Surgical's® da Vinci®). Moreover, neurosurgery--and herein spine surgery--seems an ideal candidate for computer assisted surgery. After the adoption of pure navigational support from brain surgery to spine surgery a meanwhile commercially available miniature robot (Mazor Surgical Technologies' The Spine Assist®) assists in drilling thoracic and lumbar pedicle screws. Pilot studies on efficacy, implementation into neurosurgical operating room work flow proved the accuracy of the system and we shortly outline them. Current applications are promising, and future possible developments seem far beyond imagination. But still, medical robotics is in its infancy. Many of its advantages and disadvantages must be delicately sorted out as the patients safety is of highest priority. Medical robots may achieve a physician's supplement but not substitute.

  1. Current Capabilities and Development Potential in Surgical Robotics

    Directory of Open Access Journals (Sweden)

    Mathias Hoeckelmann

    2015-05-01

    Full Text Available Commercial surgical robots have been in clinical use since the mid-1990s, supporting surgeons in various tasks. In the past decades, many systems emerged as research platforms, and a few entered the global market. This paper summarizes the currently available surgical systems and research directions in the broader field of surgical robotics. The widely deployed teleoperated manipulators aim to enhance human cognitive and physical skills and provide smart tools for surgeons, while image-guided robotics focus on surpassing human limitations by introducing automated targeting and treatment delivery methods. Both concepts are discussed based on prototypes and commercial systems. Through concrete examples the possible future development paths of surgical robots are illustrated. While research efforts are taking different approaches to improve the capacity of such systems, the aim of this survey is to assess their maturity from the commercialization point of view.

  2. Rhabdomyosarcoma: Current Challenges and Their Implications for Developing Therapies

    Science.gov (United States)

    Hettmer, Simone; Li, Zhizhong; Billin, Andrew N.; Barr, Frederic G.; Cornelison, D.D.W.; Ehrlich, Alan R.; Guttridge, Denis C.; Hayes-Jordan, Andrea; Helman, Lee J.; Houghton, Peter J.; Khan, Javed; Langenau, David M.; Linardic, Corinne M.; Pal, Ranadip; Partridge, Terence A.; Pavlath, Grace K.; Rota, Rossella; Schäfer, Beat W.; Shipley, Janet; Stillman, Bruce; Wexler, Leonard H.; Wagers, Amy J.; Keller, Charles

    2014-01-01

    Rhabdomyosarcoma (RMS) represents a rare, heterogeneous group of mesodermal malignancies with skeletal muscle differentiation. One major subgroup of RMS tumors (so-called “fusion-positive” tumors) carries exclusive chromosomal translocations that join the DNA-binding domain of the PAX3 or PAX7 gene to the transactivation domain of the FOXO1 (previously known as FKHR) gene. Fusion-negative RMS represents a heterogeneous spectrum of tumors with frequent RAS pathway activation. Overtly metastatic disease at diagnosis is more frequently found in individuals with fusion-positive than in those with fusion-negative tumors. RMS is the most common pediatric soft-tissue sarcoma, and approximately 60% of all children and adolescents diagnosed with RMS are cured by currently available multimodal therapies. However, a curative outcome is achieved in <30% of high-risk individuals with RMS, including all those diagnosed as adults, those diagnosed with fusion-positive tumors during childhood (including metastatic and nonmetastatic tumors), and those diagnosed with metastatic disease during childhood (including fusion-positive and fusion-negative tumors). This white paper outlines current challenges in RMS research and their implications for developing more effective therapies. Urgent clinical problems include local control, systemic disease, need for improved risk stratification, and characterization of differences in disease course in children and adults. Biological challenges include definition of the cellular functions of PAX-FOXO1 fusion proteins, clarification of disease heterogeneity, elucidation of the cellular origins of RMS, delineation of the tumor microenvironment, and identification of means for rational selection and testing of new combination therapies. To streamline future therapeutic developments, it will be critical to improve access to fresh tumor tissue for research purposes, consider alternative trial designs to optimize early clinical testing of candidate

  3. Current developments of coumarin compounds in medicinal chemistry.

    Science.gov (United States)

    Peng, Xin-Mei; Damu, Guri L V; Zhou, Cheng- He

    2013-01-01

    Coumarin compounds represent an important type of naturally occurring and synthetic oxygen-containing heterocycles with typical benzopyrone framework. This type of special benzopyrone structure enables its derivatives readily interact with a diversity of enzymes and receptors in organisms through weak bond interactions, thereby exhibit wide potentiality as medicinal drugs. So far, some coumarin-based drugs such as anticoagulant and antineurodegenerative agents have been extensively used in clinic. Coumarin-containing supramolecular medicinal agents as a new increasing expansion of supramolecular chemistry in pharmaceutical science have also been actively investigated in recent years. Coumarin-derived artificial ion receptors, fluorescent probes and biological stains are growing quickly and have a variety of potential applications in monitoring timely enzyme activity, complex biological events as well as accurate pharmacological and pharmacokinetic properties. This review provides a systematic summary and insight of the whole range of medicinal chemistry in the current developments of coumarin compounds as anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory and analgesic, antidiabetic, antidepressive and other bioactive agents as well as supramolecular medicinal drugs, diagnostic agents and pathologic probes, and biological stains. Some rational design strategies, structure-activity relationships and action mechanisms are discussed. The perspectives of the future development of coumarinbased medicinal chemistry are also presented.

  4. Current and Under Development Treatment Modalities of Psoriasis: A Review.

    Science.gov (United States)

    Albaghdadi, Abdul

    2017-08-04

    Psoriasis is a chronic and complex autoimmune inflammatory skin disease that affects over 125 million people worldwide. It can exhibit at any age, in spite of the fact that children are less normally influenced than adults. It is characterized by distinct erythematous plaques shielded with conspicuous silvery scales that shows up in different areas of the skin. Knowledge of pathophysiology, especially the pathogenesis of psoriasis, has significantly progressed in the recent decade. Advancement in molecular knowledge leads to better understanding of the disease, thus influencing the development of efficient treatment modalities. However, even with the availability of various options of treatment most of the efficient treatment modalities are costly. Expenses of health care bring about major financial weight to the patients as well as to health care systems. Thus, it was important to review the available current treatment options and those which are under development, in terms of efficacy, safety and cost to assist in selecting the most appropriate treatment for psoriasis patients. Literatures were searched by using key words psoriasis, topical treatment, systemic treatment, biologics and phototherapies, on Embase, Medline, Jstor, Cochrane and Merck Index databases. Life-style choices such as smoking, alcohol consumption, obesity and stress are recognised as risk factors and triggers associated with psoriasis. Psoriasis poses psycho-social and economic burden on affected patients that sometimes leads to depression, reduced social interaction and suicidal tendencies in patients. Depending on the type, severity and extent of the disease, comorbidities, patient preference, efficacy and safety profile, numerous treatment modalities and therapeutic agents are available such as topical, systemic, biologic and phototherapeutic treatments. However, it was found that among all the current available treatments for psoriasis, biologic agents and phototherapeutic modalities are

  5. Development and regulation of biosimilars: current status and future challenges.

    Science.gov (United States)

    Tsiftsoglou, Asterios S; Ruiz, Sol; Schneider, Christian K

    2013-06-01

    Biologic medicinal products developed via rDNA technology as recombinant protein-based medicines that have been in clinical use since the early 1980s as original biopharmaceuticals have greatly contributed to the therapy of severe metabolic and degenerative diseases. The recent expiration of the data protection or patents for most of them created opportunities for the development of copy versions of original biopharmaceuticals with similar biologic activity (termed biosimilars). Production of these new products is expected to meet worldwide demand, promote market competition, maintain the incentives for innovation, and sustain the healthcare systems. The licencing of these products, however, relies on the experience gained with the original biopharmaceuticals. Critical issues related to this class of medicinal products include their terminology (to avoid confusion with generics and non-innovator copy versions that have not been tested according to the biosimilar guidelines), manufacturing, and regulation. The European Union (EU) has been the first to establish a regulatory framework for marketing authorization application (MAA) and has named these products biosimilars, a term also recently adopted by the US FDA. Unlike the conventional, more common small molecular weight human medicines and chemical generics, protein-based medicines exhibit higher molecular weight, complexity in structure and function that can be affected by changes in the manufacturing process. Therefore, biosimilars represent a relatively heterogeneous class of medicinal products that make their regulation quite challenging. According to the current understanding in the EU, a biosimilar is a copy version of an already authorized biopharmaceutical (or reference product) with similar biologic activity, physicochemical characteristics, efficacy, and safety, based on a full comparability exercise at quality, preclinical and clinical level to ensure similar efficacy and safety. Guidance has been

  6. High-temperature strain measurement techniques: Current developments and challenges

    Science.gov (United States)

    Lemcoe, M. M.

    1992-01-01

    Since 1987, a very substantial amount of R&D has been conducted in an attempt to develop reliable strain sensors for the measurements of structural strains during ground testing and hypersonic flight, at temperatures up to at least 2000 deg F. Much of the effort has been focused on requirements of the NASP Program. This presentation is limited to the current sensor development work and characterization studies carried out within that program. It is basically an assessment as to where we are now and what remains to be done in the way of technical accomplishments to meet the technical challenges posed by the requirements and constraints established for the NASP Program. The approach for meeting those requirements and constraints has been multi-disciplinary in nature. It was recognized early on that no one sensor could meet all these requirements and constraints, largely because of the large temperature range (cryogenic to at least 2000 deg F) and many other factors, including the most challenging requirement that the sensor system be capable of obtaining valid 'first cycle data'. Present candidate alloys for resistance-type strain gages include Fe-Cr-Al and Pd-Cr. Although they have superior properties regarding withstanding very high temperatures, they exhibit large apparent strains that must either be accounted for or cancelled out by various techniques, including the use of a dual-element, half-bridge dummy gage, or electrical compensation networks. A significant effort is being devoted to developing, refining, and evaluating the effectiveness of those techniques over a broad range in temperature and time. In the quest to obtain first-cycle data, ways must be found to eliminate the need to prestabilize or precondition the strain gage, before it is attached to the test article. It should be noted that present NASP constraints do not permit prestabilization of the sensor, in situ. Gages are currently being 'heat treated' during manufacture in both the wire- and foil

  7. Electronic money in russia: current state and problems of development

    Directory of Open Access Journals (Sweden)

    T. G. Bondarenko

    2016-01-01

    Full Text Available Article is devoted to urgent problems of non-cash methods of calculation development by using electronic money – as one of the modern economically developed state strategic tasks. On modern economic science strong influence appears informatization process. The control expansion tendency, influence and distribution of commerce due to informatization of society led to emergence of the new phenomenon – information economy. Information economy brought new economic events which owing to their novelty are insufficiently studied to life. It is possible to carry electronic money to such phenomena of modern network economy Relevance and, in our opinion, timeliness of this scientific work, consisting in novelty of this non-cash payment method, its prospects and innovation within non-cash methods of calculations. Authors set as the purpose – studying of problems and the prospects of development of electronic money in the Russian Federation. In article theoretical bases of electronic money functioning are described. Determinations and classifications dismissed non-cash a method, and also the principles of electronic money functioning are considered, the questions of their historical development are raised.Authors analyzed statistical data on development of electronic services and channels of their using. Features, benefits and shortcomings of the current state of the market of electronic money are studied. The emphasis on that fact that in modern conditions considerable number of economic actors perform the activities, both in the real environment of economy, and within the virtual environment that promotes expansion of methods of their customer interaction by means of technical devices of personal computers, mobile phones is placed. In article common problems and tendencies of payments with using an electronic money are designated, the research on assessment of the current state and the prospects of electronic money

  8. Assessment of NDE for key indicators of aging cables in nuclear power plants - Interim status

    Science.gov (United States)

    Glass, S. W.; Ramuhalli, P.; Fifield, L. S.; Prowant, M. S.; Dib, G.; Tedeschi, J. R.; Suter, J. D.; Jones, A. M.; Good, M. S.; Pardini, A. F.; Hartman, T. S.

    2016-02-01

    Degradation of the cable jacket, electrical insulation, and other cable components of installed cables within nuclear power plants (NPPs) is known to occur as a function of age, temperature, radiation, and other environmental factors. System tests verify cable function under normal loads; however, the concern is over cable performance under exceptional loads associated with design-basis events (DBEs). The cable's ability to perform safely over the initial 40-year planned and licensed life has generally been demonstrated and there have been very few age-related cable failures. With greater than 1000 km of power, control, instrumentation, and other cables typically found in an NPP, replacing all the cables would be a severe cost burden. Justification for life extension to 60 and 80 years requires a cable aging management program to justify cable performance under normal operation as well as accident conditions. Currently the gold standard for determining cable insulation degradation is the elongation-at-break (EAB). This, however, is an ex-situ measurement and requires removal of a sample for laboratory investigation. A reliable nondestructive examination (NDE) in-situ approach is desirable to objectively determine the suitability of the cable for service. A variety of tests are available to assess various aspects of electrical and mechanical cable performance, but none of these tests are suitable for all cable configurations nor does any single test confirm all features of interest. Nevertheless, the complete collection of test possibilities offers a powerful range of tools to assure the integrity of critical cables. Licensees and regulators have settled on a practical program to justify continued operation based on condition monitoring of a lead sample set of cables where test data is tracked in a database and the required test data are continually adjusted based on plant and fleet-wide experience. As part of the Light Water Reactor Sustainability program sponsored

  9. Dengue vaccines: Challenges, development, current status and prospects

    Directory of Open Access Journals (Sweden)

    A Ghosh

    2015-01-01

    Full Text Available Infection with dengue virus (DENV is the most rapidly spreading mosquito-borne viral disease in the world. The clinical spectrum of dengue, caused by any of the four serotypes of DENV, ranges from mild self-limiting dengue fever to severe dengue, in the form dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. Increased rates of hospitalization due to severe dengue, during outbreaks, result in massive economic losses and strained health services. In the absence of specific antiviral therapy, control of transmission of DENV by vector management is the sole method available for decreasing dengue-associated morbidity. Since vector control strategies alone have not been able to satisfactorily achieve reduction in viral transmission, the implementation of a safe, efficacious and cost-effective dengue vaccine as a supplementary measure is a high public health priority. However, the unique and complex immunopathology of dengue has complicated vaccine development. Dengue vaccines have also been challenged by critical issues like lack of animal models for the disease and absence of suitable markers of protective immunity. Although no licensed dengue vaccine is yet available, several vaccine candidates are under phases of development, including live attenuated virus vaccines, live chimeric virus vaccines, inactivated virus vaccines, subunit vaccines, DNA vaccines and viral-vectored vaccines. Although some vaccine candidates have progressed from animal trials to phase II and III in humans, a number of issues regarding implementation of dengue vaccine in countries like India still need to be addressed. Despite the current limitations, collaborative effects of regulatory bodies like World Health Organization with vaccine manufacturers and policy makers, to facilitate vaccine development and standardize field trials can make a safe and efficacious dengue vaccine a reality in near future.

  10. Dengue vaccines: challenges, development, current status and prospects.

    Science.gov (United States)

    Ghosh, A; Dar, L

    2015-01-01

    Infection with dengue virus (DENV) is the most rapidly spreading mosquito-borne viral disease in the world. The clinical spectrum of dengue, caused by any of the four serotypes of DENV, ranges from mild self-limiting dengue fever to severe dengue, in the form dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Increased rates of hospitalization due to severe dengue, during outbreaks, result in massive economic losses and strained health services. In the absence of specific antiviral therapy, control of transmission of DENV by vector management is the sole method available for decreasing dengue-associated morbidity. Since vector control strategies alone have not been able to satisfactorily achieve reduction in viral transmission, the implementation of a safe, efficacious and cost-effective dengue vaccine as a supplementary measure is a high public health priority. However, the unique and complex immunopathology of dengue has complicated vaccine development. Dengue vaccines have also been challenged by critical issues like lack of animal models for the disease and absence of suitable markers of protective immunity. Although no licensed dengue vaccine is yet available, several vaccine candidates are under phases of development, including live attenuated virus vaccines, live chimeric virus vaccines, inactivated virus vaccines, subunit vaccines, DNA vaccines and viral-vectored vaccines. Although some vaccine candidates have progressed from animal trials to phase II and III in humans, a number of issues regarding implementation of dengue vaccine in countries like India still need to be addressed. Despite the current limitations, collaborative effects of regulatory bodies like World Health Organization with vaccine manufacturers and policy makers, to facilitate vaccine development and standardize field trials can make a safe and efficacious dengue vaccine a reality in near future.

  11. Nontyphoidal salmonella disease: Current status of vaccine research and development.

    Science.gov (United States)

    Tennant, Sharon M; MacLennan, Calman A; Simon, Raphael; Martin, Laura B; Khan, M Imran

    2016-06-01

    currently under development.

  12. Bulk ultrasonic NDE of metallic components at high temperature using magnetostrictive transducers

    Science.gov (United States)

    Ashish, Antony Jacob; Rajagopal, Prabhu; Balasubramaniam, Krishnan; Kumar, Anish; Rao, B. Purnachandra; Jayakumar, Tammana

    2017-02-01

    Online ultrasonic NDE at high-temperature is of much interest to the power, process and automotive industries in view of possible savings in downtime. This paper describes a novel approach to developing ultrasonic transducers capable of high-temperature in-situ operation using the principle of magnetostriction. Preliminary design from previous research by the authors [1] is extended for operation at 1 MHz, and at elevated temperatures by amorphous metallic strips as the magnetostrictive core. Ultrasonic signals in pulse-echo mode are experimentally obtained from the ultrasonic transducer thus developed, in a simulated high-temperature environment of 350 °C for 10 hours. Advantages and challenges for practical deployment of this approach are discussed.

  13. Magnetic particle imaging: current developments and future directions

    Directory of Open Access Journals (Sweden)

    Panagiotopoulos N

    2015-04-01

    Full Text Available Nikolaos Panagiotopoulos,1 Robert L Duschka,1 Mandy Ahlborg,2 Gael Bringout,2 Christina Debbeler,2 Matthias Graeser,2 Christian Kaethner,2 Kerstin Lüdtke-Buzug,2 Hanne Medimagh,2 Jan Stelzner,2 Thorsten M Buzug,2 Jörg Barkhausen,1 Florian M Vogt,1 Julian Haegele1 1Clinic for Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Campus Lübeck, 2Institute of Medical Engineering, University of Lübeck, Lübeck, Germany Abstract: Magnetic particle imaging (MPI is a novel imaging method that was first proposed by Gleich and Weizenecker in 2005. Applying static and dynamic magnetic fields, MPI exploits the unique characteristics of superparamagnetic iron oxide nanoparticles (SPIONs. The SPIONs’ response allows a three-dimensional visualization of their distribution in space with a superb contrast, a very high temporal and good spatial resolution. Essentially, it is the SPIONs’ superparamagnetic characteristics, the fact that they are magnetically saturable, and the harmonic composition of the SPIONs’ response that make MPI possible at all. As SPIONs are the essential element of MPI, the development of customized nanoparticles is pursued with the greatest effort by many groups. Their objective is the creation of a SPION or a conglomerate of particles that will feature a much higher MPI performance than nanoparticles currently available commercially. A particle’s MPI performance and suitability is characterized by parameters such as the strength of its MPI signal, its biocompatibility, or its pharmacokinetics. Some of the most important adjuster bolts to tune them are the particles’ iron core and hydrodynamic diameter, their anisotropy, the composition of the particles’ suspension, and their coating. As a three-dimensional, real-time imaging modality that is free of ionizing radiation, MPI appears ideally suited for applications such as vascular imaging and interventions as well as cellular and targeted imaging. A number

  14. Status of NDE research in the US-contributions of NDE to reactor safety and implementation of NDE technology

    Energy Technology Data Exchange (ETDEWEB)

    Ammirato, F. [EPRI, Charlotte, NC (United States)

    1999-08-01

    Power plant designers, plant owners, and regulators have developed inservice inspection (ISI) programs as part of their comprehensive approach to ensuring nuclear safety. This paper examines the role of ISI in reactor safety through several examples drawn from recent industry initiatives to address implementation of effective examination technology for nuclear power plant piping, and BWR and PWR reactor pressure vessels. These examples also illustrate the importance of well designed performance demonstration activities to support application of effective ISI. Finally, the efforts required to implement effective ISI technology for field inspection is addressed. (orig./DGE)

  15. Clinical pharmacology in Russia-historical development and current state.

    Science.gov (United States)

    Zagorodnikova Goryachkina, Ksenia; Burbello, Aleksandra; Sychev, Dmitry; Frolov, Maxim; Kukes, Vladimir; Petrov, Vladimir

    2015-02-01

    Clinical pharmacology in Russia has long history and is currently active, but rather unrecognized internationally. It is governmentally approved as a teaching/scientific specialty since 1983 and as a medical specialty since 1997. Courses of clinical pharmacology are included in the undergraduate curricula in the 5th and/or 6th year of education at all medical schools in the Russian Federation. Postgraduate education includes initial specialization in internal medicine with further residency in clinical pharmacology. Governmental legislation recommends that every healthcare institution has either a department or a single position of clinical pharmacologist. Major routine duties include information about and monitoring of medication use, consultations in difficult clinical situations, pharmacogenetic counseling, therapeutic drug monitoring, pharmacovigilance, and participation in drug and therapeutics (formulary) committees. There are official experts in clinical pharmacology in Russia responsible for coordinating relevant legislative issues. The chief expert clinical pharmacologist represents the discipline directly at the Ministry of Health. Research in clinical pharmacology in Russia is extensive and variable, but only some of it is published internationally. Russia is a participant of international societies of clinical pharmacology and therapeutics and collaboration is actively ongoing. There are still certain problems related to the development of the discipline in Russia-some healthcare institutions do not see the need for clinical pharmacology. However, the number of clinical pharmacologists in Russia is increasing as well as their role in physicians' education, national healthcare, and research.

  16. Current Developments in Prokaryotic Single Cell Whole Genome Amplification

    Energy Technology Data Exchange (ETDEWEB)

    Goudeau, Danielle; Nath, Nandita; Ciobanu, Doina; Cheng, Jan-Fang; Malmstrom, Rex

    2014-03-14

    Our approach to prokaryotic single-cell Whole Genome Amplification at the JGI continues to evolve. To increase both the quality and number of single-cell genomes produced, we explore all aspects of the process from cell sorting to sequencing. For example, we now utilize specialized reagents, acoustic liquid handling, and reduced reaction volumes eliminate non-target DNA contamination in WGA reactions. More specifically, we use a cleaner commercial WGA kit from Qiagen that employs a UV decontamination procedure initially developed at the JGI, and we use the Labcyte Echo for tip-less liquid transfer to set up 2uL reactions. Acoustic liquid handling also dramatically reduces reagent costs. In addition, we are exploring new cell lysis methods including treatment with Proteinase K, lysozyme, and other detergents, in order to complement standard alkaline lysis and allow for more efficient disruption of a wider range of cells. Incomplete lysis represents a major hurdle for WGA on some environmental samples, especially rhizosphere, peatland, and other soils. Finding effective lysis strategies that are also compatible with WGA is challenging, and we are currently assessing the impact of various strategies on genome recovery.

  17. Current developments in hernia repair; meshes, adhesives, and tacking.

    Science.gov (United States)

    Powell, Benjamin S; Voeller, Guy R

    2010-10-01

    Open and laparoscopic hernia surgery continues to evolve with new products allowing surgeons multiple choices in treating their patients. The evolution towards tension-free techniques in dealing with hernias requires that today's surgeons know the options available in meshes as well as fixation methods in order to have the best outcomes. In recent years, there has been a rapid expansion in the number of meshes available. Currently, there are numerous uncoated, coated, and biologic meshes in production that can be used in hernia repair. This paper will focus on the latest developments in coated meshes that allow for intra-abdominal placement as well as the different types of biologic meshes and their typical uses. Tacking devices for laparoscopic hernia repair now come in titanium as well as absorbable devices. AbsorbaTack™ (Covidien, Norwalk, CT) and Sorbafix™ (Davol, Warwick, RI) are two of the newest absorbable tacking devices thought to possibly benefit patients with decreased pain and long-term complications as compared with their titanium counterparts. Adhesives continue to be used more and more for hernia repair, especially in inguinal and paraesophageal hernia repairs. Tissucol™/Tisseel™ (Baxter, Deerfield, IL) and Evicel™ (Ethicon, Somerville, NJ) are two types of fibrin glues that are available for use in hernia repair. Practitioners using these biologic adhesives think there is less pain compared with tacking.

  18. Near Infrared (nir) Imaging for Nde

    Science.gov (United States)

    Diamond, G. G.; Pallav, P.; Hutchins, D. A.

    2008-02-01

    A novel application of near infrared (NIR) signals is presented, which can be used to provide images of many different materials and objects. It is effectively a very low cost non-ionising alternative to many applications currently being investigated using electromagnetic waves at other frequencies, such as THz and X-ray imaging. This alternative technique can be realised by very simple and inexpensive electronics and is inherently far more portable and easy to use. Transmission imaging results from this technique are presented from examples industrial quality control, food inspection and various security applications, and the results compared to existing techniques. In addition, this technique can be used in through-transmission mode on biological and medical samples, and images are presented that differentiate between not only flesh and bone, but also various types of soft tissue.

  19. Three-dimensional NDE of VHTR core components via simulation-based testing. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Guzina, Bojan [Univ. of Minnesota, Minneapolis, MN (United States); Kunerth, Dennis [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-09-30

    A next generation, simulation-driven-and-enabled testing platform is developed for the 3D detection and characterization of defects and damage in nuclear graphite and composite structures in Very High Temperature Reactors (VHTRs). The proposed work addresses the critical need for the development of high-fidelity Non-Destructive Examination (NDE) technologies for as-manufactured and replaceable in-service VHTR components. Centered around the novel use of elastic (sonic and ultrasonic) waves, this project deploys a robust, non-iterative inverse solution for the 3D defect reconstruction together with a non-contact, laser-based approach to the measurement of experimental waveforms in VHTR core components. In particular, this research (1) deploys three-dimensional Scanning Laser Doppler Vibrometry (3D SLDV) as a means to accurately and remotely measure 3D displacement waveforms over the accessible surface of a VHTR core component excited by mechanical vibratory source; (2) implements a powerful new inverse technique, based on the concept of Topological Sensitivity (TS), for non-iterative elastic waveform tomography of internal defects - that permits robust 3D detection, reconstruction and characterization of discrete damage (e.g. holes and fractures) in nuclear graphite from limited-aperture NDE measurements; (3) implements state-of-the art computational (finite element) model that caters for accurately simulating elastic wave propagation in 3D blocks of nuclear graphite; (4) integrates the SLDV testing methodology with the TS imaging algorithm into a non-contact, high-fidelity NDE platform for the 3D reconstruction and characterization of defects and damage in VHTR core components; and (5) applies the proposed methodology to VHTR core component samples (both two- and three-dimensional) with a priori induced, discrete damage in the form of holes and fractures. Overall, the newly established SLDV-TS testing platform represents a next-generation NDE tool that surpasses

  20. Position-Controlled Data Acquisition Embedded System for Magnetic NDE of Bridge Stay Cables

    Directory of Open Access Journals (Sweden)

    Rouven Christen

    2010-12-01

    Full Text Available This work presents a custom-tailored sensing and data acquisition embedded system, designed to be integrated in a new magnetic NDE inspection device under development at Empa, a device intended for routine testing of large diameter bridge stay cables. The data acquisition (DAQ system fulfills the speed and resolution requirements of the application and is able to continuously capture and store up to 2 GB of data at a sampling rate of 27 kS/s, with 12-bit resolution. This paper describes the DAQ system in detail, including both hardware and software implementation, as well as the key design challenges nd the techniques employed to meet the specifications. Experimental results showing the performance of the system are also presented.

  1. Economic evaluations of personalized medicine: existing challenges and current developments

    Directory of Open Access Journals (Sweden)

    Shabaruddin FH

    2015-06-01

    Full Text Available Fatiha H Shabaruddin,1 Nigel D Fleeman,2 Katherine Payne3 1Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia; 2Liverpool Reviews and Implementation Group (LRiG, University of Liverpool, Liverpool, UK; 3Institute of Population Health, The University of Manchester, Manchester, UK Abstract: Personalized medicine, with the aim of safely, effectively, and cost-effectively targeting treatment to a prespecified patient population, has always been a long-time goal within health care. It is often argued that personalizing treatment will inevitably improve clinical outcomes for patients and help achieve more effective use of health care resources. Demand is increasing for demonstrable evidence of clinical and cost-effectiveness to support the use of personalized medicine in health care. This paper begins with an overview of the existing challenges in conducting economic evaluations of genetics- and genomics-targeted technologies, as an example of personalized medicine. Our paper illustrates the complexity of the challenges faced by these technologies by highlighting the variations in the issues faced by diagnostic tests for somatic variations, generally referring to genetic variation in a tumor, and germline variations, generally referring to inherited genetic variation in enzymes involved in drug metabolic pathways. These tests are typically aimed at stratifying patient populations into subgroups on the basis of clinical effectiveness (response or safety (avoidance of adverse events. The paper summarizes the data requirements for economic evaluations of genetics and genomics-based technologies while outlining that the main challenges relating to data requirements revolve around the availability and quality of existing data. We conclude by discussing current developments aimed to address the challenges of assessing the cost-effectiveness of genetics and genomics-based technologies, which revolve around two central issues that are

  2. Advanced reflector characterization with ultrasonic phased arrays in NDE applications.

    Science.gov (United States)

    Wilcox, Paul D; Holmes, Caroline; Drinkwater, Bruce W

    2007-08-01

    Ultrasonic arrays are increasingly widely used in nondestructive evaluation (NDE) due to their greater flexibility and potentially superior performance compared to conventional monolithic probes. The characterization of small defects remains a challenge for NDE and is of great importance for determining the impact of a defect on the integrity of a structure. In this paper, a technique for characterizing reflectors with subwavelength dimensions is described. This is achieved by post-processing the complete data set of time traces obtained from an ultrasonic array using two algorithms. The first algorithm is used to obtain information about reflector orientation and the second algorithm is used to distinguish between point-like reflectors that reflect uniformly in all directions and specular reflectors that have distinct orientations. Experimental results are presented using a commercial 64-element, 5-MHZ array on two aluminum test specimens that contain a number of machined slots and side-drilled holes. The results show that the orientation of 1-mm-long slots can be determined to within a few degrees and that the signals from 1-mm-long slots can be distinguished from that from a 1-mm-diameter circular hole. Techniques for quantifying both the orientation and the specularity of measured signals are presented and the effect of processing parameters on the accuracy of results is discussed.

  3. Simulation of Phase Effects in Imaging for Mesoscale NDE

    Energy Technology Data Exchange (ETDEWEB)

    Aufderheide, III, M B; Barty, A; Martz, Jr., H E

    2004-08-26

    High energy density experiments, such as those planned at the National Ignition Facility (NIF), use mesoscale targets with the goals of studying high energy density physics, inertial confinement fusion, and the support of national security needs. Mesoscale targets are typically several millimeters in size and have complex micrometer-sized structures composed of high-density metals and low-density foams and ices. These targets are designed with exacting tolerances that are difficult to achieve at present. Deviation from these tolerances can result in compromise of experimental goals and thus it is necessary to determine as-built properties of these targets using NDE techniques. Radiography and computed tomography are being used to investigate these targets, but the mix between phase and absorption information is difficult to separate, making interpretation of results difficult. We have recently improved the HADES radiographic simulation code to include phase in simulations, as an aid for doing NDE on mesoscale targets. In this paper we report on how we extended HADES to incorporate phase effects, and compare simulations with a variety of experimental test results.

  4. Development of heating device / development of the high current ion source for neutral beam injection

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Heon Ju; Lee, Dong Gyu; Lee, Kyong Jin; Ko Tae Kyong [Cheju National Univ., Cheju (Korea)

    1998-08-01

    The design and fabrication of a high current ion source for NBI was carried out. The scale of an ion source was reduced for mock-up test. To develop the high current ion source with the high operational stability and the long lifetime, the parameters including an arc current, gas pressure and extraction voltage should be optimized. If fabricated ion source would be tested, its parameters could be optimized experimentally. Through the optimization of the ion source parameter, the core technology for NBI is established and the experiment of current drive in the fusion device can be performed. This technology also can be applied to the ion beam technology in the field of new material synthesis and semiconductor industry. 24 refs., 22 figs., 13 tabs. (Author)

  5. Current International Cooperation and Developments in Information Security

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Global information security and the threats to its integrity are becoming increasingly important. In this paper,the authors talk about areas requiring international cooperation, the major problems with current international cooperation, and finally give their reflections on international cooperation.

  6. Nuclear Power for Sustainable Development : Current Status and Future Prospects

    OpenAIRE

    Adamantiades, A.; Kessides, I.

    2009-01-01

    Interest in nuclear power has been revived as a result of volatile fossil fuel prices, concerns about the security of energy supplies, and global climate change. This paper describes the current status and future plans for expansion of nuclear power, the advances in nuclear reactor technology, and their impacts on the associated risks and performance of nuclear power. Advanced nuclear reactors have been designed to be simpler and safer, and to have lower costs than currently operating reactor...

  7. Planning for Development in the Arab Gulf States: A content Analysis of Current Development Plans

    DEFF Research Database (Denmark)

    Hvidt, Martin

    2012-01-01

    Abstract: This paper analyses current development plans published by the GCC states (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates) in order to explore the region’s future growth trajectory: what barriers to growth are foreseen and how can they be anticipated; what...

  8. Detection of fiber damage in a graphite epoxy composite using current injection and magnetic field mapping

    Science.gov (United States)

    Blalock, T. N.; Yost, W. T.

    1986-01-01

    A novel NDE technique is reported for detecting fiber disruptions in graphite-epoxy composites. The technique involves injecting electric current along the graphite fibers of a composite and measuring the resulting magnetic fields. The disruptions in current paths, which occur in areas of fiber damage, are detectable as perturbations in the magnetic field. The experimental setup, the measurements, and the magnetic images of experimental samples are presented. A resistive model has been developed to be used in the modeling of two-dimensional conductivity patterns in graphite composites. Diagrams of the setup and the circuitry are included.

  9. Development of New Dielectric NDE Techniques for Spaceflight Materials Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Dielectric spectrometry will be performed on select spacecraft materials (i.e. heat shield materials, structural materials and insulating foams) to examine their...

  10. Current State and Prospects for Development of Tourism in Russia

    Directory of Open Access Journals (Sweden)

    Ulyana V. Laktionova

    2012-05-01

    Full Text Available Tourism in Russia is a developing complex, capable of resolving a lot of social and economic issues if developed correctly. Week and strong points of Russian tourism, ways to address arising problems.

  11. Symposium: Organizational Health Intervention Research: Current Empirical Developments

    DEFF Research Database (Denmark)

    Ipsen, Christine; Jenny, Gregor

    2014-01-01

    This symposium is one of three symposia submitted by the "International organizational health intervention research partnership". The aim of this symposium is to present new empirical developments based on participatory intervention models. All five studies have developed and applied intervention...

  12. Quantitative NDE thermography for fault diagnosis of ball bearings with micro-foreign substances

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Won Tae [Div. of Mechanical and Automotive Engineering, Kongju NationalUniversity, Cheonan (Korea, Republic of); Hong, Dong Pyo [Dept. of Mechanical System Engineering, Chonbuk National Univerity, Jeonju (Korea, Republic of)

    2014-08-15

    In this study, a non-destructive evaluation (NDE) method is proposed for ball bearings contaminated with micro foreign substances, which were inserted into a ball bearing to create a defective specimen. The non-contact quantitative infrared thermographic technique was applied for NDE condition monitoring. Passive thermographic experiments were conducted to perform early fault diagnosis, for bearings operated at optimized torque status under a dynamic load condition. The temperature profiles for normal and defective specimens were quantitatively compared, and the thermographic data analyzed. Based on the NDE results, the temperature characteristics and abnormal fault detection of the ball bearing were quantitatively analyzed according to the rise in temperature.

  13. HEADROOM APPROACH TO DEVICE DEVELOPMENT: CURRENT AND FUTURE DIRECTIONS

    OpenAIRE

    Girling, A; Lilford, R; Cole, A; Young, T

    2015-01-01

    OBJECTIVES: The headroom approach to medical device development relies on the estimation of a value-based price ceiling at different stages of the development cycle. Such price-ceilings delineate the commercial opportunities for new products in many healthcare systems. We apply a simple model to obtain critical business information as the product proceeds along a development pathway, and indicate some future directions for the development of the approach. METHODS: Health economic modelling in...

  14. Current insights in the development of children's motor imagery ability.

    NARCIS (Netherlands)

    Spruijt, S.; Kamp, J. van der; Steenbergen, B.

    2015-01-01

    Over the last two decades, the number of studies on motor imagery in children has witnessed a large expansion. Most studies used the hand laterality judgment paradigm or the mental chronometry paradigm to examine motor imagery ability. The main objective of the current review is to collate these

  15. Current insights in the development of children's motor imagery ability

    NARCIS (Netherlands)

    Spruijt, S.; Kamp, J. van der; Steenbergen, B.

    2015-01-01

    Over the last two decades, the number of studies on motor imagery in children has witnessed a large expansion. Most studies used the hand laterality judgment paradigm or the mental chronometry paradigm to examine motor imagery ability. The main objective of the current review is to collate these

  16. Current insights in the development of children's motor imagery ability

    NARCIS (Netherlands)

    Spruijt, S.; Kamp, J. van der; Steenbergen, B.

    2015-01-01

    Over the last two decades, the number of studies on motor imagery in children has witnessed a large expansion. Most studies used the hand laterality judgment paradigm or the mental chronometry paradigm to examine motor imagery ability. The main objective of the current review is to collate these stu

  17. Current insights in the development of children's motor imagery ability.

    NARCIS (Netherlands)

    Spruijt, S.; Kamp, J. van der; Steenbergen, B.

    2015-01-01

    Over the last two decades, the number of studies on motor imagery in children has witnessed a large expansion. Most studies used the hand laterality judgment paradigm or the mental chronometry paradigm to examine motor imagery ability. The main objective of the current review is to collate these stu

  18. Current State and Development of China Drill Export

    Institute of Scientific and Technical Information of China (English)

    Shen Dachun; He Huanqing; Ren Keren

    2012-01-01

    Oil equipment industry is directly concerned with the development of oil and gas resources development and the national energy stability. Soaring oil prices before financial crisis push up the exploration and development of global oil resources. Surging demand for oil equipment spurs the rapid expansion of traditional oil equipment manufacturing industry.

  19. Current developments for improving efficacy of allergy vaccines.

    Science.gov (United States)

    Sandrini, Alessandra; Rolland, Jennifer M; O'Hehir, Robyn E

    2015-01-01

    Allergic diseases are prevalent worldwide. Allergen immunotherapy (AIT) is a current treatment for allergy, leading to modification of the natural course of disease. Mechanisms of efficacy include Treg through release of IL-10 and TGF-β and specific IgG4 blocking antibodies. Subcutaneous and sublingual routes are popular, but uptake is limited by inconvenience and safety concerns. Inclusion criteria limit application to a small proportion of allergic patients. New forms of immunotherapy are being investigated for more efficacious, convenient and safer options with promising advances in recent years. The rationale of reducing vaccine allergenicity to increase safety while improving immunogenicity led to investigation of T-cell epitope-based peptides and recombinant allergen derivatives. Additionally, different routes of administration and adjuvants and adjunct therapies are being explored. This review discusses the current status of AIT and recent advances to improve clinical efficacy, safety and long-term immune tolerance.

  20. The Democratic Republic of Congo: Background and Current Developments

    Science.gov (United States)

    2011-04-29

    Seko began in the city of Goma in the mid-1990s. The second rebellion in the late 1990s began also in eastern Congo. The root causes of the current...Democratic Rally (RCD- Goma ), the Movement for the Congolese Liberation (MLC), and representatives of the unarmed political groups. The agreement...from the border until a solution is found. In January 2007, several dozen rebel groups and the DRC government signed the Goma Accord, primarily

  1. Current Status & Development Trend of VSAT Market in China

    Institute of Scientific and Technical Information of China (English)

    Xu Nutu

    2006-01-01

    @@ 1. General Status of VSAT Market Development in China 1)Development History Development in China The history of the application of satellite communication in China is not too long and it was dated from the early seventies of the 20th century. In 1973, approved by Chinese government,Ministry of Posts and Telecommunications purchased satellite earth equipment from foreign country and constructed 3 stations in Shanghai and Beijing.

  2. Current Status of Oil Distribution and Development in China

    Institute of Scientific and Technical Information of China (English)

    Zhou Qingfan

    2009-01-01

    @@ China has rich oil resources, yet relatively low-quality crude oil and difficulty in exploration and development limit the pace the oil industry will be. At present, the prospects of oil development are in a moderate mature stage, the increasing trend of high basic value in oil reserves pose a huge potential of oil exploration and development in China. The most proved reserves are distributed in big-and-middle-sized basins, and will be the main fields of undiscovered oil resources. In addition,though the degree of exploration in unconventional oil is low, its development with abundance resources will be as a significant complementary resource to conventional oil.

  3. Comparison of normal and phase stepping shearographic NDE

    Science.gov (United States)

    Andhee, A.; Gryzagoridis, J.; Findeis, D.

    2005-05-01

    The paper presents results of non-destructive testing of composite main rotor helicopter blade calibration specimens using the laser based optical NDE technique known as Shearography. The tests were performed initially using the already well established near real-time non-destructive technique of Shearography, with the specimens perturbed during testing for a few seconds using the hot air from a domestic hair dryer. Subsequent to modification of the shearing device utilized in the shearographic setup, phase stepping of one of the sheared images to be captured by the CCD camera was enabled and identical tests were performed on the composite main rotor helicopter blade specimens. Considerable enhancement of the images manifesting or depicting the defects on the specimens is noted suggesting that phase stepping is a desirable enhancement technique to the traditional Shearographic setup.

  4. Practical constraints on real time Bayesian filtering for NDE applications

    Science.gov (United States)

    Summan, R.; Pierce, S.; Dobie, G.; Hensman, J.; MacLeod, C.

    2014-01-01

    An experimental evaluation of Bayesian positional filtering algorithms applied to mobile robots for Non-Destructive Evaluation is presented using multiple positional sensing data - a real time, on-robot implementation of an Extended Kalman and Particle filter was used to control a robot performing representative raster scanning of a sample. Both absolute and relative positioning were employed - the absolute being an indoor acoustic GPS system that required careful calibration. The performance of the tracking algorithms are compared in terms of computational cost and the accuracy of trajectory estimates. It is demonstrated that for real time NDE scanning, the Extended Kalman Filter is a more sensible choice given the high computational overhead for the Particle filter.

  5. Finite Elements, Design Optimization, and Nondestructive Evaluation: A Review in Magnetics, and Future Directions in GPU-based, Element-by-Element Coupled Optimization and NDE

    Science.gov (United States)

    2013-07-18

    Element Coupled Optimization and NDE S. Ratnajeevan H. Hoole1, Victor U. Karthik1, Sivamayam Sivasuthan1, Arunasalam Rahunanthan2, Ravi S...Department of Mathematics and Statistics, University of Toledo , Toledo , OH 43606-3390, USA. 3. The US Army Tank Automotive Research, Development and...PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Paramsothy Jayakumar; Ravi Thyagarajan; Arunasalam Rahunanthan; Sivamayam Sivasuthan; Victor Karthik 5d

  6. Current Research and Development of Chemotherapeutic Agents for Melanoma

    Directory of Open Access Journals (Sweden)

    Kyaw Minn Hsan

    2010-04-01

    Full Text Available Cutaneous malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on conventional chemotherapeutic drugs for melanoma treatment, by a single or combinational agent approach, but also summarizes some potential novel phytoagents discovered from dietary vegetables or traditional herbal medicines as alternative options or future medicine for melanoma prevention. We explore the mode of actions of these natural phytoagents against metastatic melanoma.

  7. Current State and Development Trends for Integration Platforms

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The integration platform (IP) is an advanced support tool for application softwa re development and integration. This paper analyzes the shortcomings of traditio nal software programming methods, introduces the background and development of i ntegration platforms and presents the basic functions and system architecture of computer integrated manufacture computing environment (CCE) IP as well as the i ntegration framework. Computer integrated manufacturing system (CIMS) applicatio n IP is defined i n relation to the IP requirements for CIMS implementation within a company. The CIMS application IP is not only a support tool for application software developm ent, but also a support tool for software integration and system operation. Ther efore, the behavior and functions of a CIMS application IP must also include sof tware integration and system operation. The development trend for CIMS applicati on IPs is discussed in view of software technology development trends.

  8. Current Developments in Communications Law in the United States

    Science.gov (United States)

    Hadl, Robert D.

    1973-01-01

    Article reviews some of the major developments in communications law in the United States in the past year (1972). Significant events are covered in the areas of cable television, television programming and domestic satelites. (Author)

  9. Current Status and Prediction on Development of PE Market

    Institute of Scientific and Technical Information of China (English)

    Yu Jiao

    2003-01-01

    This article comprehensively analyzes the status of market demand/supply and import/export volumes of PE in the world and in China, and predicts the future development trends in the fields of PE production and consumption.

  10. Current trends in the clinical development of peptide therapeutics.

    Science.gov (United States)

    Saladin, Pauline M; Zhang, Bodi D; Reichert, Janice M

    2009-12-01

    The development of peptides as drugs is attracting increasing attention from the pharmaceutical industry. This interest is at least partially a consequence of the widespread acceptance of therapeutic proteins by physicians and patients, and because of improvements to problems such as a short half-life and delivery issues. The markets for peptide-based compounds can be substantial, with six peptide drugs attaining global sales of more than US $750 million in 2008. To track trends in the clinical development and marketing approval of peptides, Tufts Center for the Study of Drug Development and Ferring Research Institute compiled publically available data for peptides that entered clinical trials sponsored by commercial firms, with a focus on peptide therapeutics, but also including peptide vaccines and diagnostics. The results provide an historical overview of the development of peptide therapeutics, and may inform strategic planning in this area.

  11. Current trends of the development of chemical analysis

    Directory of Open Access Journals (Sweden)

    Rema Matakova

    2014-12-01

    Full Text Available This paper presents dynamics of the development of all stages of chemical analysis during last 15 years. The ways of the quality improvement of chemical analysis and its considerable advancement into the field of trace concentrations of substances are shown. Features of development of analytical methods, modern techniques for concentration and separation of substances, as well as chemomerrical processing of results are analyzed. Huge importance of computerization and automation of the analysis is shown.

  12. The Current of Continuing Professional Development for Product Designers

    OpenAIRE

    山内, 勉; Yamauchi, Tsutomu

    2010-01-01

    Product Designers are required some skills and knowledge in the product development. Based on my professional career, I presumed three skills, they are, Technical skills, Conceptual skills and Human skills. In this study, I interviewed some Product Designers to make sure what skills are needed in the product development process. It emerged that Product Designers are expected to improve their Conceptual and Human skills besides Technical skills for playing a part at the upper and lower stage o...

  13. Radiation damage of biomolecules (RADAM) database development: current status

    Science.gov (United States)

    Denifl, S.; Garcia, G.; Huber, B. A.; Marinković, B. P.; Mason, N.; Postler, J.; Rabus, H.; Rixon, G.; Solov'yov, A. V.; Suraud, E.; Yakubovich, A. V.

    2013-06-01

    Ion beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue, while maximizing cell killing within the tumour. However, as the underlying dependent physical, chemical and biological processes are too complex to treat them on a purely analytical level, most of our current and future understanding will rely on computer simulations, based on mathematical equations, algorithms and last, but not least, on the available atomic and molecular data. The viability of the simulated output and the success of any computer simulation will be determined by these data, which are treated as the input variables in each computer simulation performed. The radiation research community lacks a complete database for the cross sections of all the different processes involved in ion beam induced damage: ionization and excitation cross sections for ions with liquid water and biological molecules, all the possible electron - medium interactions, dielectric response data, electron attachment to biomolecules etc. In this paper we discuss current progress in the creation of such a database, outline the roadmap of the project and review plans for the exploitation of such a database in future simulations.

  14. Mevva development for the new GSI high-current injector

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, B.H.; Emig, H.; Spaedtke, P. [Gesellschaft fuer Schwerionenforschung, Darmstadt (Germany)

    1996-08-01

    To increase the intensity of the heavy ion synchrotron SIS for heavy elements by a factor of {approximately}50, a new prestripper accelerator is planned for Unilac and the heavy ion synchrotron SIS. It is designed to accept ions with mass/charge {le} 65 and an injection energy of 2.2 keV/u. A vacuum arc ion source with a strong axial magnetic field will deliver 15 mA of U{sup 4+} as heaviest element at a repetition rate of 1 Hz and a pulse length of 300 {mu}s. The investigation of the Mevva ion source with pulsed magnetic field of several kGauss have shown that ion currents of 8 mA U{sup 4+} can be measured at the authors test bench after 5m of transport and charge analysis (transmission at the test bench 25% only). The noise on the extracted ion beam was already {le}25%, a value similar to the Pig ion source in the sputter mode, but efficient high current beam transport probably requests further improvements.

  15. Entering the Era of "Super" NDE Instruments, Followed by Progressive Miniaturization Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An ideal NDE data acquisition and analysis tool would be a versatile and precise device capable of providing support for a large number of inspections using numerous...

  16. Siserände üldsuunad / Tiit Tammaru, Hill Kulu, Inga Kask

    Index Scriptorium Estoniae

    Tammaru, Tiit, 1972-

    2003-01-01

    Siserände suundade analüüs kinnitas uurimuse hüpoteese, et 1990. aastatel valitses asustushierarhia tasemete vaheline linnastumine ja linnaregioonidesisene eeslinnastumine. Graafik. Tabelid. Skeem. Diagrammid. Kaardid. Lisa lk. 27

  17. Siserände üldsuunad / Tiit Tammaru, Hill Kulu, Inga Kask

    Index Scriptorium Estoniae

    Tammaru, Tiit, 1972-

    2003-01-01

    Siserände suundade analüüs kinnitas uurimuse hüpoteese, et 1990. aastatel valitses asustushierarhia tasemete vaheline linnastumine ja linnaregioonidesisene eeslinnastumine. Graafik. Tabelid. Skeem. Diagrammid. Kaardid. Lisa lk. 27

  18. Novel Ultra-Miniature Flexible Videoscope for On-Orbit NDE Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Conventional videoscopes for NDE suffer many shortcomings, including large diameter, limited flexibility, inadequate image quality, high cost and lack of 3D imaging...

  19. Telehealth in the developing world: current status and future prospects

    Directory of Open Access Journals (Sweden)

    Scott RE

    2015-02-01

    Full Text Available Richard E Scott,1,2 Maurice Mars11Department of TeleHealth, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa; 2NT Consulting - Global e-Health Inc., Calgary, AB, CanadaAbstract: In a setting of constant change and confusing terminology, telehealth continues to gain ground in both developed and developing countries within the overarching milieu of e-health. Evidence shows telehealth has been used in essentially all countries of the world, but is embedded in few. Uses and needs of telehealth vary between the developed and developing world; the latter struggles with both communicable diseases and noncommunicable diseases, and with very few resources. Common clinical applications include teleconsultation, telecardiology (transmission of ECGs, teleradiology, and teledermatology. Many telehealth projects exist throughout Latin America and the Caribbean, Asia, and Africa, but there is little published evidence and only isolated examples of sustained programs, although several sustained humanitarian networks exist. Application of mobile solutions (m-health is on the rise in many developing countries. Telehealth is still not integrated into existing health care systems globally. Reasons vary: lack of proven large-scale operations, poor evidence base, inadequate implementation, lack of attention to the “soft side” of implementation (readiness, change management, and many others. For the developing world, reasons can be more pragmatic, including limited resources, unreliable power, poor connectivity, and high cost for the poverty stricken – those most in need. Telehealth is poised to improve health and health care in the developing world, driven by both altruistic and profit motives. But to have the desired effect, telehealth must address very specific and evidence-based health “needs” of each facility, region, or country; the shortage of health workers and specialist services; and the required skills upgrading and training

  20. Development and current status of the "Cambridge" loudness models.

    Science.gov (United States)

    Moore, Brian C J

    2014-10-13

    This article reviews the evolution of a series of models of loudness developed in Cambridge, UK. The first model, applicable to stationary sounds, was based on modifications of the model developed by Zwicker, including the introduction of a filter to allow for the effects of transfer of sound through the outer and middle ear prior to the calculation of an excitation pattern, and changes in the way that the excitation pattern was calculated. Later, modifications were introduced to the assumed middle-ear transfer function and to the way that specific loudness was calculated from excitation level. These modifications led to a finite calculated loudness at absolute threshold, which made it possible to predict accurately the absolute thresholds of broadband and narrowband sounds, based on the assumption that the absolute threshold corresponds to a fixed small loudness. The model was also modified to give predictions of partial loudness-the loudness of one sound in the presence of another. This allowed predictions of masked thresholds based on the assumption that the masked threshold corresponds to a fixed small partial loudness. Versions of the model for time-varying sounds were developed, which allowed prediction of the masked threshold of any sound in a background of any other sound. More recent extensions incorporate binaural processing to account for the summation of loudness across ears. In parallel, versions of the model for predicting loudness for hearing-impaired ears have been developed and have been applied to the development of methods for fitting multichannel compression hearing aids.

  1. Application of quality by design in the current drug development

    Directory of Open Access Journals (Sweden)

    Lan Zhang

    2017-01-01

    Full Text Available Quality by Test was the only way to guarantee quality of drug products before FDA launched current Good Manufacturing Practice. To clearly understand the manufacture processes, FDA generalized Quality by Design (QbD in the field of pharmacy, which is based on the thorough understanding of how materials and process parameters affect the quality profile of final products. The application of QbD in drug formulation and process design is based on a good understanding of the sources of variability and the manufacture process. In this paper, the basic knowledge of QbD, the elements of QbD, steps and tools for QbD implementation in pharmaceutics field, including risk assessment, design of experiment, and process analytical technology (PAT, are introduced briefly. Moreover, the concrete applications of QbD in various pharmaceutical related unit operations are summarized and presented.

  2. Beyond the current political economy of competence development

    DEFF Research Database (Denmark)

    Olesen, Henning Salling

    2013-01-01

    of learning for work. This opens a new arena of political struggle over the direction of learning processes and the participation of workers in work and society. The socio-economic realities and a new understanding of the interrelationship between knowledge, skills, learning and practice central...... to the competence concept, raises a potential issue about the role of work and the living worker in a capitalist economy. This requires a re-development of the notion of economy based in the value and interest of working people, and enabled by the full development of the competences of the workers themselves....... A notion of the “political economy of working people” is proposed as a framework for investigating the potentials of competence development for enhanced democracy....

  3. Forest certification in Russia: development, current state and problems

    Directory of Open Access Journals (Sweden)

    Lukashevich Victor

    2016-03-01

    Full Text Available The article analyzes the development of voluntary forest certification by the Forest Stewardship Council (FSC system in Russia. The article is based on the review of diverse information sources, analysis of the reports of timber processing enterprises, personal observations during certification audits, discussions in workgroups, and information collected at training courses. We evaluated the present state of voluntary forest certification in Russia, analyzed non-compliances of the activity of Russian wood processing enterprises with the national standard FSC-STD-RUS-V6-1-2012 and indicated possible reasons for non-fulfillment of the requirements. We also presented problems in the development of forest certification in Russia and possible ways for its further development.

  4. Orphan drugs in development for urea cycle disorders: current perspectives

    Directory of Open Access Journals (Sweden)

    Häberle J

    2014-09-01

    Full Text Available Johannes Häberle,1 Shawn E McCandless2 1Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; 2Center for Human Genetics, University Hospitals Case Medical Center, and Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA Abstract: The urea cycle disorders are caused by deficiency of one of the six hepatic enzymes or two transporters involved in detoxification of ammonia. The resulting hyperammonemia causes severe brain injury unless aggressive steps are taken to reduce the accumulation of ammonia, which is thought to be the most toxic metabolite. This review describes the current state of chronic management of urea cycle disorders, focusing on new and emerging therapies. Management strategies include the mainstay of treatment, namely dietary protein restriction and supplementation with l-arginine or l-citrulline. Several currently approved medications utilize and enhance alternative pathways of waste nitrogen excretion (sodium benzoate, sodium phenylacetate, sodium phenylbutyrate in several formulations, and glycerol phenylbutyrate, working through conjugation of the drug to either glycine (in the case of benzoate or glutamine, the products of which are excreted in the urine. Carglumic acid activates the first committed step of conversion of ammonia to urea, carbamoylphosphate synthetase, and thus effectively treats defective synthesis of the endogenous activator, N-acetylglutamate, whether due to genetic defects or biochemical inhibition of the N-acetylglutamate synthase enzyme. Approaches to neuroprotection during episodes of hyperammonemia are discussed, including the use of controlled hypothermia (brain cooling, as well as proposed, but as yet untested, pharmacologic therapies. Finally, cell-based therapies, including liver transplantation, infusion of fresh or cryopreserved hepatocytes, use of stem cells, and new approaches to gene

  5. TÜRKİYE’DE İŞYERİNDE PSİKOLOJİK TACİZ ORANININ VE TÜRLERİNİN BELİRLENMESİ: BİR ÖLÇEK GELİŞTİRME ÇALIŞMASI, MEASURING THE OCCURRENCE AND TYPES OF WORKPLACE BULLYING IN TURKEY: A SCALE DEVELOPMENT STUDY

    Directory of Open Access Journals (Sweden)

    Sibel GÖK

    2010-07-01

    Full Text Available Özet:Bu araştırmanın amacı, Türk çalışma hayatındapsikolojik taciz oranını ve türlerini belirlemek içinkullanılabilecek geçerli ve güvenilir bir ölçek geliştirmekolarak belirlenmiştir. Araştırma Mart-Haziran 2009 tarihleriarasında, İstanbul’da hizmet sektöründe istihdam edilen 908katılımcı ile gerçekleştirilmiştir. Veri toplama aracı olaraktarafımızdan hazırlanan soru formu kullanılmıştır. İstatistikselanalizde, açıklayıcı faktör analizi ve güvenirlik analizindenyararlanılmıştır. Açıklayıcı faktör analizi sonucunda 28maddeden oluşan dört faktörlü “İşyerinde Psikolojik TacizÖlçeği” (İPTÖ geliştirilmiştir (KMO katsayısı = 0,950,Barlettt testi χ2(378 = 10523,337, P(sigma = 0.000. Güvenirlikanalizi sonucu, ölçeğin yüksek bir iç tutarlılık katsayısınasahip olduğunu göstermiştir (α = 0,933. Katılımcıların%13,5’inin İPTÖ’ye göre işyerinde psikolojik taciz mağduruolduğu saptanmıştır. “Yukarıdan aşağıya doğru” ve “işeyönelik davranışların yöneltildiği” psikolojik taciz, en sıkkarşılaşılan türler arasında yer almıştır. Araştırma bulgularıİPTÖ’nün, bundan sonra gerçekleştirilecek ve Türk çalışmahayatında psikolojik taciz oranını ve türlerini belirlemeyihedefleyen çalışmalar için geçerli ve güvenilir bir ölçekolduğunu desteklemektedir.Abstract:The aim of the present study was to develop a validand reliable scale investigating the occurrence and types ofworkplace bullying in Turkey. The sample consisted of 908employees from the services sector in Istanbul and the datawere collected between March and June 2009 using aquestionnaire developed for this purpose. Reliability andexploratory factor analysis were used. Exploratory factoranalysis indicated that four factor scale comprising 28 itemsprovided the best fit to the data (χ2(378=10523.337, KMO=0.95,p=0.000. Reliability analysis showed that the

  6. Current Situation and Challenges of Plantation Development in China

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The area of plantation in China ranks the first in the world. But, many challenges are still faced in the development of China’s plantation. A review of plantation in China was presented and the challenges were analyzed. The plantation features juvenile and middle age class with low diameter at breast height. There are the risks of pests and diseases in plantation, the potential decline in land fertility and bio-diversity, all of which are unfavorable to a healthy development of plantations.

  7. [Current situation and development trend of Chinese medicine information research].

    Science.gov (United States)

    Dong, Yan; Cui, Meng

    2013-04-01

    Literature resource service was the main service that Chinese medicine (CM) information offered. But in recent years users have started to request the health information knowledge service. The CM information researches and application service mainly included: (1) the need of strength studies on theory, application of technology, information retrieval, and information standard development; (2) Information studies need to support clinical decision making, new drug research; (3) Quick response based on the network monitoring and support to emergency countermeasures. CM information researches have the following treads: (1) developing the theory system structure of CM information; (2) studying the methodology system of CM information; (3) knowledge discovery and knowledge innovation.

  8. [Current situation and challenges in companion diagnostics development].

    Science.gov (United States)

    Nishida, Miwa

    2014-12-01

    The personalized health care, it is defined as a medical care which provide the optimal therapy for each individual in consideration of a patient's individual difference, such as a genetic background and a physiological state. A companion diagnosis to stratify a patient appropriately is essential for the spread of personalized health care, and it is important that a companion diagnostic reagent used for the companion diagnosis is properly developed and clinically applied. However, as for the development of companion diagnostics and pharmaceuticals that require it, there are still many challenges such as its business model of cooperation of diagnostics companies and pharmaceutical companies, also, the regulations related to companion diagnostics. Furthermore, even in clinical practice, there are many issues such as the way of reimbursement for companion diagnostics and also the handling of laboratory developed test (LDT) as companion diagnostics. These are issues that should continue to discuss with industry, government and academia. In this report, from the point of view of a diagnostics company, we discuss the various challenges in clinical applications from the development of companion diagnostics.

  9. Collection Development in Elementary School Libraries: Current Practice.

    Science.gov (United States)

    Pojman, Paul E.

    1987-01-01

    Looks at collection development for print materials in school libraries serving children in grades K-8. The policy statement and the processes of evaluation, selection, acquisition, and weeding are examined, emphasizing the place of curriculum objectives and the role of the librarian. Twenty-two references and a bibliography of 15 selection tools…

  10. The Development and Current Status of an Occupational Classification.

    Science.gov (United States)

    Holland, John L.

    The author summarizes the origin of his occupational classification scheme, the main events in its development, and its present form. A number of deficiencies in this classification scheme are addressed, and the virtues of the scheme are enumerated. Although the present classification is the outcome of much empirical work, individual…

  11. Behavioral medicine in China: history, current status, and future development.

    Science.gov (United States)

    Bai, Bo; Ji, Feng

    2014-08-01

    Behavioral medicine in China has developed quickly in the last three decades. We briefly summarized the history, the main scope and achievements, and the future development of behavioral medicine in China. We did a literature search and discussed with senior scholars in behavioral medicine in China. The concept and main scope of behavioral medicine in China have been developed largely in accordance with the international perspective. Research in behavioral medicine in China significantly contributed to the better understanding of the relationship between various health behavioral factors and psychosomatic disorders and possible mechanisms of this relationship. The following aspects will be the main areas to be further developed in behavioral medicine in China: (1) Basic theories of behavioral medicine and theoretical mechanisms of higher nervous activities in human behavior regulation. (2) Etiology, pathogenesis, and mechanisms of common diseases that are closely related to human lifestyle behaviors. (3) Assessment criteria for unhealthy and disease-related behaviors. (4) Behavioral therapy of psychosomatic disorders, and rehabilitation technologies of disability. (5) Application of major findings from research of behavioral medical science in clinical practice and in health promotion of the whole society. Behavioral medicine in China, as a multidisciplinary subject, plays a relevant role in preventing behavior-related psychosomatic diseases and in promoting health of the public.

  12. Current Developments in Proficiency Evaluation for African Languages.

    Science.gov (United States)

    Dwyer, David J., Ed.

    The essays collected here describe events, trends, and issues in the development of language proficiency testing for African languages. Papers include: "A Brief History of Proficiency Testing" (Richard T. Thompson, Dora E. Johnson); "The 1986 Stanford ACTFL Training Workshop" (William Leben); "The 1987 Madison-MSU Team…

  13. Electric bicycles in The Netherlands: Current developments and future possibilities

    NARCIS (Netherlands)

    Rooijen, T. van

    2010-01-01

    Developments with electric bicycles in the Netherlands are progressing rapidly. The number of electric bicycles sold is rises every year. Cycling is a very popular mode of transport in The Netherlands. In 2008 more than one million bicycles were sold. At the moment one out of ten bicycles sold is al

  14. Electric bicycles in The Netherlands: Current developments and future possibilities

    NARCIS (Netherlands)

    Rooijen, T. van

    2010-01-01

    Developments with electric bicycles in the Netherlands are progressing rapidly. The number of electric bicycles sold is rises every year. Cycling is a very popular mode of transport in The Netherlands. In 2008 more than one million bicycles were sold. At the moment one out of ten bicycles sold is

  15. New and Traditional Multilateral Development Banks: Current and Potential Cooperation

    Directory of Open Access Journals (Sweden)

    Andrei Shelepov

    2017-03-01

    Full Text Available Most experts on multilateral development banks (MDBs mention the possibility of large-scale co-financing in their forecasts concerning their future operations. However, interaction between MDBs and other actors, including co-financing, is rarely considered as a research problem for analytical and scientific papers. Yet this type of cooperation is one of the most important factors of effectiveness for the entire system of MDB financing. Thus, working in partnership with governmental institutions (development assistance agencies, export credit agencies, etc., MDBs help attract additional financial resources and expertise in the countries where they are active. Working on state, regional and global levels, multilateral banks cooperate not only with governmental institutions, but also with private sector and civil society representatives. Such cooperation benefits both parties. In addition to mobilizing additional financial resources, it improves project preparation and implementation, taking into account national peculiarities, while partner institutions get a chance to use their experience and expertise. Given the recent establishment of the New Development Bank (NDB and Asian Infrastructure Investment Bank (AIIB, they are unlikely to achieve their main goal of narrowing the infrastructure financing deficit in developing countries without active cooperation with other institutions. This article discusses the results and examines the prospects of the NDB and AIIB cooperating with traditional MDBs. It also focuses on the new banks’ engagement with other financial institutions, including commercial banks and national development banks. The author analyzes interbank memorandums and agreements as a formal basis for cooperation between various institutions, and examines in detail the examples of co-financing infrastructure projects by the new and traditional MDBs, as well as new multilateral cooperation mechanisms established by development banks. The

  16. Current Development in Elderly Comprehensive Assessment and Research Methods

    Directory of Open Access Journals (Sweden)

    Shantong Jiang

    2016-01-01

    Full Text Available Comprehensive geriatric assessment (CGA is a core and an essential part of the comprehensive care of the aging population. CGA uses specific tools to summarize elderly status in several domains that may influence the general health and outcomes of diseases of elderly patients, including assessment of medical, physical, psychological, mental, nutritional, cognitive, social, economic, and environmental status. Here, in this paper, we review different assessment tools used in elderly patients with chronic diseases. The development of comprehensive assessment tools and single assessment tools specially used in a dimension of CGA was discussed. CGA provides substantial insight into the comprehensive management of elderly patients. Developing concise and effective assessment instruments is helpful to carry out CGA widely to create a higher clinical value.

  17. Current developments lighter than air systems. [heavy lift airships

    Science.gov (United States)

    Mayer, N. J.

    1981-01-01

    Lighter than air aircraft (LTA) developments and research in the United States and other countries are reviewed. The emphasis in the U.S. is on VTOL airships capable of heavy lift, and on long endurance types for coastal maritime patrol. Design concepts include hybrids which combine heavier than air and LTA components and characteristics. Research programs are concentrated on aerodynamics, flight dynamics, and control of hybrid types.

  18. [Robotic single site surgery: current practice and future developments].

    Science.gov (United States)

    Buchs, N C; Pugin, F; Volonté, F; Jung, M; Hagen, M E; Morel, P

    2012-06-20

    Robotic surgery has been gaining increasing acceptance for several years now, establishing itself with success in all the surgical fields. Besides, since the introduction of single site surgery, the interest for the robotic technology is more than obvious, offering technical possibilities to overcome the natural limitations of laparoscopy. This article reviews the different devices available and the indications of robotic single site surgery. Moreover, the future developments of this new technology are discussed as well.

  19. CURRENT STATE AND PROSPECTS OF UKRAINIAN BAKING INDUSTRY DEVELOPMENT

    OpenAIRE

    Завертаний, Д. В.

    2016-01-01

    The transformation processes taking place in the Ukrainian economy show the necessitate of the innovative approaches formation at baking enterprises. To improve the efficiency, enterprises in baking industry should not only optimize transport and energy costs, but also develop an effective pricing strategy for finished products. It should be noted that there is a need to run modern technological production lines that will make possible to reduce the prime cost of the finished product. Despite...

  20. Current and future trends in metagenomics : Development of knowledge bases

    Science.gov (United States)

    Mori, Hiroshi; Yamada, Takuji; Kurokawa, Ken

    Microbes are essential for every part of life on Earth. Numerous microbes inhabit the biosphere, many of which are uncharacterized or uncultivable. They form a complex microbial community that deeply affects against surrounding environments. Metagenome analysis provides a radically new way of examining such complex microbial community without isolation or cultivation of individual bacterial community members. In this article, we present a brief discussion about a metagenomics and the development of knowledge bases, and also discuss about the future trends in metagenomics.

  1. Bioresorbable vascular scaffolds technology: current use and future developments

    Directory of Open Access Journals (Sweden)

    Giacchi G

    2016-07-01

    Full Text Available Giuseppe Giacchi, Luis Ortega-Paz, Salvatore Brugaletta, Kohki Ishida, Manel Sabaté Cardiology Department, Clinic Cardiovascular Institute, Hospital Clinic, August Pi and Sunyer Biomedical Research Institute (IDIBAPS, University of Barcelona, Barcelona, Spain Abstract: Coronary bioresorbable vascular scaffolds are a new appealing therapeutic option in interventional cardiology. The most used and studied is currently the Absorb BVS™. Its backbone is made of poly-l-lactide and coated by a thin layer of poly-d,l-lactide, it releases everolimus and is fully degraded to H2O and CO2 in 2–3 years. Absorb BVS™ seems to offer several theoretical advantages over metallic stent, as it gives temporary mechanical support to vessel wall without permanently caging it. Therefore, long-term endothelial function and structure are not affected. A possible future surgical revascularization is not compromised. Natural vasomotion in response to external stimuli is also recovered. Several observational and randomized trials have been published about BVS clinical outcomes. The main aim of this review is to carry out a systematic analysis about Absorb BVS™ studies, evaluating also the technical improvements of the Absorb GT1 BVS™. Keywords: Absorb GT1, Absorb BVS™, bioresorbable vascular scaffold, BRS, coronary scaffold

  2. High Brightness, High Average Current Injector Development at Cornell

    CERN Document Server

    Sinclair, C K

    2005-01-01

    Cornell University is constructing a 100 mA average current, high brightness electron injector for a planned Energy Recovery Linac (ERL) hard X-ray synchrotron radiation source. This injector will employ a very high voltage DC gun with a negative electron affinity photoemission cathode. Relatively long duration electron pulses from the photocathode will be drift bunched, and accelerated to 5-15 MeV with five two-cell, 1300 MHz superconducting cavities. The total beam power will be limited to 575 kW by the DC and RF power sources. A genetic algorithm based computational optimization of this injector has resulted in simulated rms normalized emittances of 0.1 mm-mrad at 80 pC/bunch, and 0.7 mm-mrad at 1 nC/bunch. The many technical issues and their design solutions will be discussed. Construction of the gun and the SRF cavities is well underway. The schedule for completion, and the planned measurements, will be presented.

  3. SAPHO Syndrome: Current Developments and Approaches to Clinical Treatment.

    Science.gov (United States)

    Firinu, Davide; Garcia-Larsen, Vanessa; Manconi, Paolo Emilio; Del Giacco, Stefano R

    2016-06-01

    SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare autoimmune disease which, due to its clinical presentation and symptoms, is often misdiagnosed and unrecognized. Its main features are prominent inflammatory cutaneous and articular manifestations. Treatments with immunosuppressive drugs have been used for the management of SAPHO with variable results. To date, the use of anti-TNF-α agents has proved to be an effective alternative to conventional treatment for unresponsive or refractory SAPHO cases. TNF-α is a pro-inflammatory cytokine and pivotal regulator of other cytokines, including IL-1 β, IL-6, and IL-8, involved in inflammation, acute-phase response induction, and chemotaxis. IL-1 inhibition strategies with anakinra have shown efficacy as first and second lines of treatment. In this review, we will describe the main characteristics of biological drugs currently used for SAPHO syndrome. We also describe some of the promising therapeutic effects of ustekinumab, an antibody against the p40 subunit of IL-12 and IL-23, after failure of multiple drugs including anti-TNF-α and anakinra. We discuss the use and impact of the new anti-IL-1 antagonists involved in the IL-17 blockade, in particular for the most difficult-to-treat SAPHO cases.

  4. Current and future developments in diesel powered hovercraft

    Science.gov (United States)

    Leonard, J. C.; Stevens, M. J.; Buttigieg, J. A.

    After evaluating the development status of the application of diesel power to air-cushion vehicles (ACVs) and surface-effect ships (SESs), attention is given to the AP1-88 ACV, which is both the first and largest operational diesel-powered amphibious craft of this type. An account is given of the ACV and SES features that are dictated by the need to accommodate diesel power sources; the major advantages and disadvantages of diesel (vs gas turbine) engines are discussed. Although cost reductions are achievable against gas turbine powerplant use, lower payload fractions and slightly lower performance capabilities appear to be inescapable.

  5. Current Status of Dengue Therapeutics Research and Development.

    Science.gov (United States)

    Low, Jenny G H; Ooi, Eng Eong; Vasudevan, Subhash G

    2017-03-01

    Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  6. Community mental health care worldwide: current status and further developments.

    Science.gov (United States)

    Thornicroft, Graham; Deb, Tanya; Henderson, Claire

    2016-10-01

    This paper aims to give an overview of the key issues facing those who are in a position to influence the planning and provision of mental health systems, and who need to address questions of which staff, services and sectors to invest in, and for which patients. The paper considers in turn: a) definitions of community mental health care; b) a conceptual framework to use when evaluating the need for hospital and community mental health care; c) the potential for wider platforms, outside the health service, for mental health improvement, including schools and the workplace; d) data on how far community mental health services have been developed across different regions of the world; e) the need to develop in more detail models of community mental health services for low- and middle-income countries which are directly based upon evidence for those countries; f) how to incorporate mental health practice within integrated models to identify and treat people with comorbid long-term conditions; g) possible adverse effects of deinstitutionalization. We then present a series of ten recommendations for the future strengthening of health systems to support and treat people with mental illness.

  7. Summary of Martian Dust Filtering Challenges and Current Filter Development

    Science.gov (United States)

    O'Hara, William J., IV

    2017-01-01

    Traditional air particulate filtering in manned spaceflight (Apollo, Shuttle, ISS, etc.) has used cleanable or replaceable catch filters such as screens and High-Efficiency Particulate Arrestance (HEPA) filters. However, the human mission to Mars architecture will require a new approach. It is Martian dust that is the particulate of concern but the need also applies to particulates generated by crew. The Mars Exploration Program Analysis Group (MEPAG) high-lighted this concern in its Mars Science, Goals, Objectives, Investigations and Priorities document [7], by saying specifically that one high priority investigation will be to "Test ISRU atmospheric processing systems to measure resilience with respect to dust and other environmental challenge performance parameters that are critical to the design of a full-scale system." By stating this as high priority the MEPAG is acknowledging that developing and adequately verifying this capability is critical to success of a human mission to Mars. This architecture will require filtering capabilities that are highly reliable, will not restrict the flow path with clogging, and require little to no maintenance. This paper will summarize why this is the case, the general requirements for developing the technology, and the status of the progress made in this area.

  8. [Cyclers for APD: current potential and possible developments].

    Science.gov (United States)

    Corciulo, R; Russo, R

    2009-01-01

    The use of automated peritoneal dialysis (APD) is rapidly increasing worldwide. The success of this treatment is closely linked to the development of new mechanical devices (cyclers). At present, the cyclers available in Italy are the Baxter Home Choice Pro, the Fresenius Sleep Safe, and the Gambro Serena. Today's cyclers are characterized by a user-friendly, intuitive interface and sophisticated software. The miniaturization of components has led to a significant reduction of the weight and size of these machines and great flexibility in treatment scheduling. The memory card (patient card) and the possibility of remote control (teledialysis) allow continuous monitoring of the patients and their compliance to treatment. The cyclers of the future could optimize their performance by biosensors able to assess, in real time, the dialysis dose while sensors placed on the drainage line could facilitate the early diagnosis of peritonitis. The peritoneal clearance could be increased with the development of continuous-flow peritoneal dialysis (CFPD). Finally, the introduction of cyclers able to prepare individually tailored solutions different from the standard ones could better meet the clinical needs of the patients and reduce the exposure of the peritoneal membrane to high concentrations of glucose.

  9. Next-generation dengue vaccines: novel strategies currently under development.

    Science.gov (United States)

    Durbin, Anna P; Whitehead, Stephen S

    2011-10-01

    Dengue has become the most important arboviral infection worldwide with more than 30 million cases of dengue fever estimated to occur each year. The need for a dengue vaccine is great and several live attenuated dengue candidate vaccines are proceeding through clinical evaluation. The need to induce a balanced immune response against all four DENV serotypes with a single vaccine has been a challenge for dengue vaccine developers. A live attenuated DENV chimeric vaccine produced by Sanofi Pasteur has recently entered Phase III evaluation in numerous dengue-endemic regions of the world. Viral interference between serotypes contained in live vaccines has required up to three doses of the vaccine be given over a 12-month period of time. For this reason, novel DENV candidate vaccines are being developed with the goal of achieving a protective immune response with an immunization schedule that can be given over the course of a few months. These next-generation candidates include DNA vaccines, recombinant adenovirus vectored vaccines, alphavirus replicons, and sub-unit protein vaccines. Several of these novel candidates will be discussed.

  10. Current perspective of the renewable energy development in Malaysia

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Salsabila [Department of Electrical and Electronics Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 Serdang, Selangor (Malaysia); Department of Electrical System Engineering, Universiti Malaysia Perlis, 02000 Kuala Perlis, Perlis (Malaysia); Kadir, Mohd Zainal Abidin Ab [Alternative and Renewable Energy Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor (Malaysia); Shafie, Suhaidi [Department of Electrical and Electronics Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 Serdang, Selangor (Malaysia)

    2011-02-15

    It is estimated that oil reserves will not last very much longer; thus, a switch to alternative energy solutions is crucial. The Malaysian government has already prepared to face the situation decades before. Many policies have been implemented, as well as programmes and initiative. Now, Malaysia is waiting for the ultimate solutions, the Malaysian Fit-in Tariff (FiT), which is scheduled to be implemented second quarter of 2011. This paper presents the main sources of alternative renewable energy in Malaysia and its potential as well as the main reasons Malaysia is turning to alternative energy solutions; to fully utilize its renewable energy (RE) resources, fulfill the energy demand in the future and to reduce carbon emissions. This paper also discusses the steps taken by the government in preparation for FiT and overcoming the barriers in RE development. (author)

  11. The Development and Current State of Translation Process Research

    DEFF Research Database (Denmark)

    Lykke Jakobsen, Arnt

    2014-01-01

    which simultaneously tracks the translator’s eye movements across a screen displaying both a source text and the translator’s emerging translation. This research method was developed as a means of qualifying and strengthening translation process hypotheses based on verbal reports by providing additional...... remains inaccessible to outside observation. What mental processes underlie measurable (micro)behaviour can only be inferred. A multi-methodological approach is clearly called for in order to capture the full complexity of translation, and translation studies must be open to extend its curiosity beyond...... itself, into regions like cognitive psychology, psycho- and neurolinguistics, and neuroscience, where the interest in what goes on in our heads is also very strong....

  12. Current developments in optical data storage with organic dyes.

    Science.gov (United States)

    Mustroph, Heinz; Stollenwerk, Manfred; Bressau, Volker

    2006-03-20

    The main motivation for the development of digital data storage has been the improvement in play-back quality and the increase in storage capacity. In 1982 Philips and Sony introduced the first technically and economically successful system based on this-the compact disc (CD) and a compatible player. A very broad diversity of optical data recording formats are available today, and a difference is drawn between prerecorded, recordable, and rewritable media. This Review gives an overview of the systems used, the main features of production, and then concentrates on the properties of the organic dyes that are used in recordable systems. Dyestuffs chemistry has gained the reputation of having become a mature field of activity. Is this prejudice or a justified swan song for dyestuffs chemistry? When applications in optical data storage are considered, it is evident that even today progresses such as CD-R and DVD/R would not be feasible without functional dyes.

  13. Animal venom studies: Current benefits and future developments

    Institute of Scientific and Technical Information of China (English)

    Yuri; N; Utkin

    2015-01-01

    Poisonous organisms are represented in many taxa, including kingdom Animalia. During evolution, animals have developed special organs for production and injection of venoms. Animal venoms are complex mixtures, compositions of which depend on species producing venom. The most known and studied poisonous terrestrial animals are snakes, scorpions and spiders. Among marine animals, these are jellyfishes, anemones and cone snails. The toxic substances in the venom ofthese animals are mainly of protein and peptide origin. Recent studies have indicated that the single venom may contain up to several hundred different components producing diverse physiological effects. Bites or stings by certain poisonous species result in severe envenomations leading in some cases to death. This raises the problem of bite treatment. The most effective treatment so far is the application of antivenoms. To enhance the effectiveness of such treatments, the knowledge of venom composition is needed. On the other hand, venoms contain substances with unique biological properties, which can be used both in basic science and in clinical applications. The best example of toxin application in basic science is α-bungarotoxin the discovery of which made a big impact on the studies of nicotinic acetylcholine receptor. Today compositions of venom from many species have already been examined. Based on these data, one can conclude that venoms contain a large number of individual components belonging to a limited number of structural types. Often minor changes in the amino acid sequence give rise to new biological properties. Change in the living conditions of poisonous animals lead to alterations in the composition of venoms resulting in appearance of new toxins. At the same time introduction of new methods of proteomics and genomics lead to discoveries of new compounds, which may serve as research tools or as templates for the development of novel drugs. The application of these sensitive and

  14. Prediction of atrial fibrillation development and progression:current perspectives

    Institute of Scientific and Technical Information of China (English)

    Konstantinos Vlachos; Konstantinos P Letsas; Panagiotis Korantzopoulos; Tong Liu; Stamatis Georgopoulos; Athanasios Bakalakos; Nikolaos Karamichalakis; Sotirios Xydonas; Michael Efremidis; Antonios Sideris

    2016-01-01

    Atrial fibrillation(AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression(from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF.

  15. Prenatal screening: current practice, new developments, ethical challenges.

    Science.gov (United States)

    de Jong, Antina; Maya, Idit; van Lith, Jan M M

    2015-01-01

    Prenatal screening pathways, as nowadays offered in most Western countries consist of similar tests. First, a risk-assessment test for major aneuploides is offered to pregnant women. In case of an increased risk, invasive diagnostic tests, entailing a miscarriage risk, are offered. For decades, only conventional karyotyping was used for final diagnosis. Moreover, several foetal ultrasound scans are offered to detect major congenital anomalies, but the same scans also provide relevant information for optimal support of the pregnancy and the delivery. Recent developments in prenatal screening include the application of microarrays that allow for identifying a much broader range of abnomalities than karyotyping, and non-invasive prenatal testing (NIPT) that enables reducing the number of invasive tests for aneuploidies considerably. In the future, broad NIPT may become possible and affordable. This article will briefly address the ethical issues raised by these technological developments. First, a safe NIPT may lead to routinisation and as such challenge the central issue of informed consent and the aim of prenatal screening: to offer opportunity for autonomous reproductive choice. Widening the scope of prenatal screening also raises the question to what extent 'reproductive autonomy' is meant to expand. Finally, if the same test is used for two different aims, namely detection of foetal anomalies and pregnancy-related problems, non-directive counselling can no longer be taken as a standard. Our broad outline of the ethical issues is meant as an introduction into the more detailed ethical discussions about prenatal screening in the other articles of this special issue.

  16. [Preimplantation embryo development: current status and perspectives in clinical embryology].

    Science.gov (United States)

    Royère, D; Guérif, F

    2008-11-01

    Preimplantation embryo development is one of the key features with implantation itself to achieve a pregnancy. Assisted Reproductive Technologies (ART) both in human and animal have improved our knowledge on these events, although predicting embryo potential to give a baby remains elusive. However data from the last 10 years have allowed either to hierarchize the available parameters or to open some new perspectives to predict embryo developmental potential. Both kinetics and morphological parameters belong to noninvasive quality embryo assessment for many years, although recent data on microvideographic analysis and multivariate analysis led to reduce their biological meaning. Moreover, new technical detection of meiotic spindle birefringency or zona pellucida anisotropy has improved the oocyte quality assessment with a deep impact for countries with restrictive legislation. Beyond such morphological criteria, more functional approaches concerned the oocyte (embryo) or its environment. Direct transcriptomic analysis, while invasive and therefore experimental, brought important data on embryo "quality". However, noninvasive metabolomic or proteomic analysis of embryo media gave promising results as well as respirometry. The environment of the oocyte has focused a specific attention, either based on regulatory proteins or cytokines present in follicular fluid, or involving genes or proteins from cumulus cells, as oocyte-cumulus dialog is a key factor in oocyte maturation. Whereas it is not possible for the time being to predict which parameter(s) will be implemented routinely, all data obtained underline that the ability to develop and implant is not based on embryo superlatives (more rapid, expressing more genes or proteins, larger metabolites uptake) but rather on a quiet state, as claimed by Leese some years ago, where a lot of resources would not be mobilized by any stressful situation.

  17. Prediction of atrial fibrillation development and progression: Current perspectives.

    Science.gov (United States)

    Vlachos, Konstantinos; Letsas, Konstantinos P; Korantzopoulos, Panagiotis; Liu, Tong; Georgopoulos, Stamatis; Bakalakos, Athanasios; Karamichalakis, Nikolaos; Xydonas, Sotirios; Efremidis, Michael; Sideris, Antonios

    2016-03-26

    Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression (from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF.

  18. Aircraft with outboard horizontal stabilizers, history, current status, development potential

    Science.gov (United States)

    Kentfield, John A. C.

    2009-08-01

    The potential of using outboard horizontal stabilizers (OHS) to reduce aircraft drag, and hence improve fuel economy, was investigated historically, experimentally and theoretically. The feasibility of OHS configurations on the basis of the structural stress levels expected was also studied. The findings of the work showed that from simple, low Reynolds number, wind-tunnel tests, at a wing-chord-based Reynolds number of approximately 6×10 4 and also from theoretical analyses for a higher Reynolds number of 9×10 6, lift/drag ( L/ D) value increases in the region of 40-50% for wing and tail surfaces can be expected relative to corresponding values for conventional aircraft. When account is taken of fuselage and tail-support boom drag, the expected overall L/ D increase is in the region of 30-35%. The analytical stress-level work showed that contrary to what, on a first thought basis, might be expected, there were no major stress problems. Flight tests at the University of Calgary, and by others elsewhere, employing radio-controlled, powered, model aircraft (i.e. UAVs) showed that aircraft of the OHS type were easily controlled in flight and were stable. An examination was made of additional areas that may contribute yet further to the development of the OHS concept.

  19. Current Developments and Best Practice in Open and Distance Learning

    Directory of Open Access Journals (Sweden)

    Armando Rocha Trinidade

    2000-06-01

    Full Text Available Through the many documents regularly emitted by those dedicated to this activity, it is comparatively easy to describe factual developments in the field of open and distance education in different places in the world. However, it is much more difficult to produce judgements of value about their quality. Quality is a subjective rather than an absolute concept and may be examined from different analytical perspectives: consumers' satisfaction level, intrinsic value of scientific and technical content of learning materials, soundness of learning strategies, efficiency of organisation and procedures, adequate use of advanced technologies, reliability of student support mechanisms, etc.These parameters should be put into the context of specific objectives, nature of target populations and availability of different kinds of resources. In a specific geographic, social, economic and cultural situation a given set of solutions might be judged as adequate and deserving the qualification of "good practice," while in a different context it could be considered of rather poor quality.The selection of examples in this article is the sole responsibility of the authors: neither should the chosen cases be considered as clearly better than any other one, nor missing cases be interpreted as lack of appreciation or a negative judgement.Finally, the authors are aware of the risks of interpreting trends and trying to extrapolate them into the near future: readers should use their own judgement in accepting (or forcefully rejecting these projections.

  20. Current status of robotic assisted pelvic surgery and future developments.

    Science.gov (United States)

    Ahmed, Kamran; Khan, Mohammad Shamim; Vats, Amit; Nagpal, Kamal; Priest, Oliver; Patel, Vanash; Vecht, Joshua A; Ashrafian, Hutan; Yang, Guang-Zhong; Athanasiou, Thanos; Darzi, Ara

    2009-10-01

    The aim of this review is to assess the role of robotics in pelvic surgery in terms of outcomes. We have also highlighted the issues related to training and future development of robotic systems. We searched MEDLINE, EMBASE and the Cochrane Databases from 1980 to 2009 for systematic reviews of randomised controlled trials, prospective observational studies, retrospective studies and case reports assessing robotic surgery. During the last decade, there has been a tremendous rise in the use of robotic surgical systems for all forms of precision operations including pelvic surgery. The short-term results of robotic pelvic surgery in the fields of urology, colorectal surgery and gynaecology have been shown to be comparable to the laparoscopic and open surgery. Robotic surgery offers an opportunity where many of these obstacles encountered during open and laparoscopic surgery can be overcome. Robotic surgery is a continually advancing technology, which has opened new horizons for performing pelvic surgery with precision and accuracy. Although its use is rapidly expanding in all surgical disciplines, particularly in pelvic surgery, further comparative studies are needed to provide robust guidance about the most appropriate application of this technology within the surgical armamentarium.

  1. Overview of robotic colorectal surgery: Current and future practical developments.

    Science.gov (United States)

    Roy, Sudipta; Evans, Charles

    2016-02-27

    Minimal access surgery has revolutionised colorectal surgery by offering reduced morbidity and mortality over open surgery, while maintaining oncological and functional outcomes with the disadvantage of additional practical challenges. Robotic surgery aids the surgeon in overcoming these challenges. Uptake of robotic assistance has been relatively slow, mainly because of the high initial and ongoing costs of equipment but also because of limited evidence of improved patient outcomes. Advances in robotic colorectal surgery will aim to widen the scope of minimal access surgery to allow larger and more complex surgery through smaller access and natural orifices and also to make the technology more economical, allowing wider dispersal and uptake of robotic technology. Advances in robotic endoscopy will yield self-advancing endoscopes and a widening role for capsule endoscopy including the development of motile and steerable capsules able to deliver localised drug therapy and insufflation as well as being recharged from an extracorporeal power source to allow great longevity. Ultimately robotic technology may advance to the point where many conventional surgical interventions are no longer required. With respect to nanotechnology, surgery may eventually become obsolete.

  2. Solar and Space Weather Radiophysics Current Status and Future Developments

    CERN Document Server

    Gary, Dale E

    2005-01-01

    The book explores what can be learned about the Sun and interplanetary space using present-day and future radio observations and techniques. The emphasis is on interpretation of radio data with high spatial and spectral resolution, motivated by the planned construction of a new, powerful, solar-dedicated radio array called the Frequency Agile Solar Radiotelescope (FASR). The book is unique in exploring a broad frequency range, which corresponds to heights ranging from the low solar atmosphere out to the Earth. The book contains a thorough review of the entire field of solar and Space Weather radio research; gives background information suitable for advanced undergraduates, graduates, and researchers in solar and Space Weather research and related fields; and looks at what new results may be expected in the next two decades with FASR and other new instruments now under development. The individual chapters are written by international experts in each topic, and although each chapter may be read as a stand-alone...

  3. Welfare state: Milestones of development and the current status

    Directory of Open Access Journals (Sweden)

    D A Zakharyan

    2016-12-01

    Full Text Available The article describes the evolution of ideas about the social state as a fair state based on the concept of the social contract. L. von Stein argues that the purpose of the welfare state was not changing the class structure of society and the elimination of the contradictions between the classes, but rather balancing and minimizing conflicts with the help of property transformations allowing a person to change one’s class affiliation. The main condition for the existence of the welfare state is its policies compliance with the interests of citizens, which provides political stability and social security. The central idea of the welfare constitutional state is that the rights of citizens are guaranteed by the state. The functions of the state and its social responsibilities were transforming over time mainly due to the erosion of state, private and corporate responsibility for providing social services. In most cases, the social programs are developed by the state, but they can also be provided by commercial organizations in the “consumer society”, in which all things and services have a material value and benefit. The welfare state is based on the principle of social justice in the distribution of wealth among the population, thus, every democratic state seeks to become a welfare state, which implies a high level of confidence in the government.

  4. Curative treatment of oesophageal carcinoma: current options and future developments

    Directory of Open Access Journals (Sweden)

    Bruns Christiane

    2011-05-01

    Full Text Available Abstract Since the 1980s major advances in surgery, radiotherapy and chemotherapy have established multimodal approaches as curative treatment options for oesophageal cancer. In addition the introduction of functional imaging modalities such as PET-CT created new opportunities for a more adequate patient selection and therapy response assessment. The majority of oesophageal carcinomas are represented by two histologies: squamous cell carcinoma and adenocarcinoma. In recent years an epidemiological shift towards the latter was observed. From a surgical point of view, adenocarcinomas, which are usually located in the distal third of the oesophagus, may be treated with a transhiatal resection, whereas squamous cell carcinomas, which are typically found in the middle and the upper third, require a transthoracic approach. Since overall survival after surgery alone is poor, multimodality approaches have been developed. At least for patients with locally advanced tumors, surgery alone can no longer be advocated as routine treatment. Nowadays, scientific interest is focused on tumor response to induction radiochemotherapy. A neoadjuvant approach includes the early and accurate assessment of clinical response, optimally performed by repeated PET-CT imaging and endoscopic ultrasound, which may permit early adaption of the therapeutic concept. Patients with SCC that show clinical response by PET CT are considered to have a better prognosis, regardless of whether surgery will be performed or not. In non-responding patients salvage surgery improves survival, especially if complete resection is achieved.

  5. Current Developments in Research on the Teaching of Grammar

    Institute of Scientific and Technical Information of China (English)

    Hossein Nassaji; Sandra Fotos

    2006-01-01

    @@ Continued from Issue 61 Textual Enhancement There are a number of studies that have investigated the effects of textual enhancement on drawing the learner's attention to grammar, and the method has been described as the least explicit and the least intrusive method of focus on form (Doughty & Varela, 1998). It involves highlighting certain features of input that might go unnoticed under normal circumstances by typographically manipulating them through boldfacing, italicizing, underlining, or capitalizing. The assumption is that such manipulations enhance the perceptual saliency of the target structures, and this, hence, increases their chance of being noticed. A related technique is the provision of numerous instances of target linguistic forms in the input, called an input flood (Trahey & While, 1993). Again,the assumption is that frequent exposure to target items enhances their saliency and hence results in noticing the forms (Schmidt, 1990; Sharwood Smith, 1993). Whereas studies by Doughty (1991) and Fotos (1994) reported positive results in terms of awareness of target structures and proficiency gains resulting from textually enhanced structures, a study by White (1998) did not show that learners who received textually enhanced input differed significantly in their ability to use the target structure compared with those who did not.White concluded that the method of enhancement may not have been sufficiently explicit to draw the learners' attention to the type of linguistic features that involved L1-L2 contrasts. Similarly, Leow (2001) investigated the effects of textual enhancement on learning Spanish formal imperatives and found no advantage for enhanced text over unenhanced text.Finally, Izumi (2001) compared two types of focus on form strategies, output and visual input enhancement, on the learning of English relativization by adult ESL learners, finding that those who produced output developed more than those merely received input. However, the visual

  6. Current Developments in Antimicrobial Surface Coatings for Biomedical Applications.

    Science.gov (United States)

    Swartjes, J J T M; Sharma, P K; van Kooten, T G; van der Mei, H C; Mahmoudi, M; Busscher, H J; Rochford, E T J

    2015-01-01

    Bacterial adhesion and subsequent biofilm formation on material surfaces represent a serious problem in society from both an economical and health perspective. Surface coating approaches to prevent bacterial adhesion and biofilm formation are of increased importance due to the increasing prevalence of antibiotic resistant bacterial strains. Effective antimicrobial surface coatings can be based on an anti-adhesive principle that prevents bacteria to adhere, or on bactericidal strategies, killing organisms either before or after contact is made with the surface. Many strategies, however, implement a multifunctional approach that incorporates both of these mechanisms. For anti-adhesive strategies, the use of polymer chains, or hydrogels is preferred, although recently a new class of super-hydrophobic surfaces has been described which demonstrate improved anti-adhesive activity. In addition, bacterial killing can be achieved using antimicrobial peptides, antibiotics, chitosan or enzymes directly bound, tethered through spacer-molecules or encased in biodegradable matrices, nanoparticles and quaternary ammonium compounds. Notwithstanding the ubiquitous nature of the problem of microbial colonization of material surfaces, this review focuses on the recent developments in antimicrobial surface coatings with respect to biomaterial implants and devices. In this biomedical arena, to rank the different coating strategies in order of increasing efficacy is impossible, since this depends on the clinical application aimed for and whether expectations are short- or long term. Considering that the era of antibiotics to control infectious biofilms will eventually come to an end, the future for biofilm control on biomaterial implants and devices is likely with surface-associated modifications that are non-antibiotic related.

  7. Wave-current interactions: model development and preliminary results

    Science.gov (United States)

    Mayet, Clement; Lyard, Florent; Ardhuin, Fabrice

    2013-04-01

    The coastal area concentrates many uses that require integrated management based on diagnostic and predictive tools to understand and anticipate the future of pollution from land or sea, and learn more about natural hazards at sea or activity on the coast. The realistic modelling of coastal hydrodynamics needs to take into account various processes which interact, including tides, surges, and sea state (Wolf [2008]). These processes act at different spatial scales. Unstructured-grid models have shown the ability to satisfy these needs, given that a good mesh resolution criterion is used. We worked on adding a sea state forcing in a hydrodynamic circulation model. The sea state model is the unstructured version of WAVEWATCH III c (Tolman [2008]) (which version is developed at IFREMER, Brest (Ardhuin et al. [2010]) ), and the hydrodynamic model is the 2D barotropic module of the unstructured-grid finite element model T-UGOm (Le Bars et al. [2010]). We chose to use the radiation stress approach (Longuet-Higgins and Stewart [1964]) to represent the effect of surface waves (wind waves and swell) in the barotropic model, as previously done by Mastenbroek et al. [1993]and others. We present here some validation of the model against academic cases : a 2D plane beach (Haas and Warner [2009]) and a simple bathymetric step with analytic solution for waves (Ardhuin et al. [2008]). In a second part we present realistic application in the Ushant Sea during extreme event. References Ardhuin, F., N. Rascle, and K. Belibassakis, Explicit wave-averaged primitive equations using a generalized Lagrangian mean, Ocean Modelling, 20 (1), 35-60, doi:10.1016/j.ocemod.2007.07.001, 2008. Ardhuin, F., et al., Semiempirical Dissipation Source Functions for Ocean Waves. Part I: Definition, Calibration, and Validation, J. Phys. Oceanogr., 40 (9), 1917-1941, doi:10.1175/2010JPO4324.1, 2010. Haas, K. A., and J. C. Warner, Comparing a quasi-3D to a full 3D nearshore circulation model: SHORECIRC and

  8. Eddy current measurement system evaluation for corrosion depth determination on cast aluminum aircraft structure

    Science.gov (United States)

    Singh, Surendra; Greving, Dan; Kinney, Andy; Vensel, Fred; Ohm, Jim; Peeler, Mike

    2013-01-01

    An eddy current (EC) technique was developed to determine the corrosion depth on a bare flange face of a cast aluminum A356-T6 aircraft engine structure. The EC response and the corrosion depths determined through metallurgical cross sections were used to develop an empirical relation between EC response and depth. The EC technique and depth determination are used to inspect the engine structures during overhaul to determine if they are fit for continued service. An accurate and reliable Non-Destructive Inspection is required to ensure that structures returned to service are safe for continued operation. NDE system reliability demonstrations of the eddy current technique are traditionally reported in terms of Probability of Detection (POD) data using MIL-HDBK-1823A. However, the calculation of POD data is based on a simple linear predictive model that is valid only if certain criteria are met. These are: 1) NDE system response is measurable (i.e. continuous data), 2) Flaw size is known and measurable (i.e. continuous data), 3) relationship between the NDE system response and flaw size is linear (or linear on a log scale), 4) variation in measured responseresponse around a predicted response for a given flaw size is normally distributed, 5) the variation around the predicted response is constant (i.e. variation does not change with flaw size), and 6) inherent variability in the NDE system is known and fully understood. In this work, a Measurement System Evaluation (MSE) of the Eddy Current System was used to address some of these concerns. This work was completed on two aircraft structures having varying corrosion depths. The data were acquired in a random manner at fifty regions of interests (ROIs). Three operators participated in this study, and each operator measured Eddy Current response three times in each ROI. In total, there were four hundred and fifty data points collected. Following this, the two structures were sectioned for measuring corrosion depth. The

  9. Ensemble of classifiers for confidence-rated classification of NDE signal

    Science.gov (United States)

    Banerjee, Portia; Safdarnejad, Seyed; Udpa, Lalita; Udpa, Satish

    2016-02-01

    Ensemble of classifiers in general, aims to improve classification accuracy by combining results from multiple weak hypotheses into a single strong classifier through weighted majority voting. Improved versions of ensemble of classifiers generate self-rated confidence scores which estimate the reliability of each of its prediction and boost the classifier using these confidence-rated predictions. However, such a confidence metric is based only on the rate of correct classification. In existing works, although ensemble of classifiers has been widely used in computational intelligence, the effect of all factors of unreliability on the confidence of classification is highly overlooked. With relevance to NDE, classification results are affected by inherent ambiguity of classifica-tion, non-discriminative features, inadequate training samples and noise due to measurement. In this paper, we extend the existing ensemble classification by maximizing confidence of every classification decision in addition to minimizing the classification error. Initial results of the approach on data from eddy current inspection show improvement in classification performance of defect and non-defect indications.

  10. Development of a Peltier Current Lead for the 200-m-Class Superconducting Direct Current Transmission and Distribution System

    Science.gov (United States)

    Kawahara, Toshio; Emoto, Masahiko; Watanabe, Hirofumi; Hamabe, Makoto; Yamaguchi, Sataro; Hikichi, Yasuo; Minowa, Masahiro

    2013-07-01

    Reducing cryogenic heat leaks is critical for superconducting applications. Reduction of heat leak at the terminals is essential for uses with short-length applications, where cryogenic losses at the terminals dominate. We are developing a 200-m-class superconducting direct current (DC) transmission and distribution system (CASER-2), and have used a Peltier current lead (PCL) for heat insulation at the terminals. The PCL consists of thermoelectric elements and copper leads, which enhance the performance of superconducting systems. As DC flows through the current lead, thermoelectric elements on opposite terminations of a superconducting line can be used to decrease the heat ingress to the cryogenic environment ( n-type on one end, p-type on the opposite end). During the current feeding and cooling test, a large temperature difference was observed across thermoelectric elements in the PCL. This demonstrates that we have successfully insulated the heat leak at the current lead. During the fourth cooling test, we established a new PCL design with p-type elements at terminal B, and then compared the performance of the terminals. Several improvements were implemented, including balancing the resistances of the PCL to enhance the stability of the superconducting systems.

  11. Materials and NDE aspects in the RPV operating conditions behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Rupa, Nathalie [EDF, CEIDRE, 2 rue Ampere, F- 93206 Saint-Denis (France); Churier-Bossennec, Henriette [Electricite de France, SEPTEN, 12 - 14 av. Dutrievoz, 69628 Villeurbanne Cedex (France); Bezdikian, Georges [EDF CAPE, 1 place Pleyel, 93282 St Denis Cedex (France)

    2006-09-15

    The demonstration of the in-service resistance of the PWR vessels is based on the toughness evaluation of the materials constituting the vessels. The objective is indeed to compare the toughness to the solicitations applied on a crack, resulting from the different loading potentially experienced by the component. This article aims at presenting the in-service inspections - NDE aspects - as well as the toughness assessment method, closely linked with different materials aspects. The potential defects in the welded, cladded shells of the PWR vessels are only fabrication flaws. To date every core zone vessel has been entirely examined by a non destructive process. The implemented Ultrasonic Techniques are qualified according to the RSEM code since 1999. Thus, EDF has a reliable and exhaustive knowledge of the manufacturing defects to be found under the cladding of the PWR vessel core zones. The toughness of the materials is determined according to an indirect method. It is based on a codified lower bound curve associating the minimum K{sub IC} to a reference temperature, the RT{sub NDT}. RT{sub NDT} is characteristic for a material and integrates the evolutions due to neutronic bombardment through specific irradiation formulae. The Pressure Vessel Surveillance Program allows to verify that the formulae are conservative. The PVSP results and an analysis of the toughness assessment are presented in this paper. (authors)

  12. Current Developments

    DEFF Research Database (Denmark)

    Arnt Nielsen, Peter

    2014-01-01

    The most important amendments to the Brussels I Regulation as adopted during the recast negotiations are presented and discussed. The author focuses on four subjects: first, the application of Brussels I to cases where the defendant is domiciled outside the EU; second, the abolition of exequatur;......; third, the improved efficiency of exclusive choice-of-court agreements; and, fourth, the relationship between litigation and arbitration....

  13. Bond strength evaluation in adhesive joints using NDE and DIC methods

    Science.gov (United States)

    Poudel, Anish

    decrease of bond shear strength in single lap shear test samples. Through-transmission ultrasonics (TTU) Acoustography at 3.8 MHz showed promising results on the detectability of bondline defects in adhesively bonded CFRP-Al lap shear test samples. A correlation between Acoustography ultrasonic attenuation and average bond shear strength in CFRP-Al lap shear panels demonstrated that differential attenuation increased with the reduction of the bond shear strength. Similarly, optical DIC tests were conducted to identify and quantify kissing bond defects in CFRP-Al single lap shear joints. DIC results demonstrated changes in the normal strain (epsilonyy) contour map of the contaminated specimens at relatively lower load levels (15% ~ 30% of failure loads). Kissing bond regions were characterized by negative strains, and these were attributed to high compressive bending strains and the localized disbonding taking placed at the bondline interface as a result of the load application. It was also observed that contaminated samples suffered from more compressive strains (epsilonyy) compared to the baseline sample along the loading direction and they suffered from less compressive strains (epsilonxx) compared to the baseline sample perpendicular to the loading direction. This demonstrated the adverse effect of the kissing bond on the adhesive joint integrity. This was a very significant finding for the reason that hybrid ultrasonic DIC is being developed as a faster, more efficient, and more reliable NDE technique for determining bond quality and predicting bond shear strength in adhesively bonded structures.

  14. Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities

    Science.gov (United States)

    Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities, a 2013 workshop sponsored by the Epidemiology and Genomics Research Program.

  15. Computerized fracture critical and specialized bridge inspection program with NDE applications

    Science.gov (United States)

    Fish, Philip E.

    1998-03-01

    Wisconsin Department of Transportation implemented a Fracture Critical & Specialized Inspection Program in 1987. The program has a strong emphasis on Nondestructive Testing (NDT). The program is also completely computerized, using laptop computers to gather field data, digital cameras for pictures, and testing equipment with download features. Final inspection reports with detailed information can be delivered within days of the inspection. The program requires an experienced inspection team and qualified personnel. Individuals performing testing must be licensed ASNT (American Society for Nondestructive Testing) Level III and must be licensed Certified Weld Inspectors (American Welding Society). Several critical steps have been developed to assure that each inspection identifies all possible deficiencies that may be possible on a Fracture Critical or Unique Bridge. They include; review of all existing plans and maintenance history; identification of fracture critical members, identification of critical connection details, welds, & fatigue prone details, development of visual and NDE inspection plan; field inspection procedures; and a detailed formal report. The program has found several bridges with critical fatigue conditions which have resulted in replacement or major rehabilitation. In addition, remote monitoring systems have been installed on structures with serious cracking to monitor for changing conditions.

  16. Continuous development of current sheets near and away from magnetic nulls

    Science.gov (United States)

    Kumar, Sanjay; Bhattacharyya, R.

    2016-04-01

    The presented computations compare the strength of current sheets which develop near and away from the magnetic nulls. To ensure the spontaneous generation of current sheets, the computations are performed congruently with Parker's magnetostatic theorem. The simulations evince current sheets near two dimensional and three dimensional magnetic nulls as well as away from them. An important finding of this work is in the demonstration of comparative scaling of peak current density with numerical resolution, for these different types of current sheets. The results document current sheets near two dimensional magnetic nulls to have larger strength while exhibiting a stronger scaling than the current sheets close to three dimensional magnetic nulls or away from any magnetic null. The comparative scaling points to a scenario where the magnetic topology near a developing current sheet is important for energetics of the subsequent reconnection.

  17. Current Situations and Countermeasures of Development of Kiwifruit Industry in Guizhou Province

    Institute of Scientific and Technical Information of China (English)

    HUANG Wei; WAN Ming-chang; YANG Sheng-jun; ZHANG Xue; QIAO Rong

    2012-01-01

    On the basis of current development situations of planting, scientific research and processing of kiwifruit industry in Guizhou Province, the paper analyzes main factors restricting development of kiwifruit industry, including lack of unified planning, standardized planting specifications, and backward management of kiwifruit orchard. In accordance with current development situations and restricting factors, the paper presents some countermeasures for development of kiwifruit industry in Guizhou Province, including scientific planning, optimizing variety structure, management of cultivation technology, training of kiwifruit farmers, as well as marketing.

  18. Incorporation of composite defects from ultrasonic NDE into CAD and FE models

    Science.gov (United States)

    Bingol, Onur Rauf; Schiefelbein, Bryan; Grandin, Robert J.; Holland, Stephen D.; Krishnamurthy, Adarsh

    2017-02-01

    Fiber-reinforced composites are widely used in aerospace industry due to their combined properties of high strength and low weight. However, owing to their complex structure, it is difficult to assess the impact of manufacturing defects and service damage on their residual life. While, ultrasonic testing (UT) is the preferred NDE method to identify the presence of defects in composites, there are no reasonable ways to model the damage and evaluate the structural integrity of composites. We have developed an automated framework to incorporate flaws and known composite damage automatically into a finite element analysis (FEA) model of composites, ultimately aiding in accessing the residual life of composites and make informed decisions regarding repairs. The framework can be used to generate a layer-by-layer 3D structural CAD model of the composite laminates replicating their manufacturing process. Outlines of structural defects, such as delaminations, are automatically detected from UT of the laminate and are incorporated into the CAD model between the appropriate layers. In addition, the framework allows for direct structural analysis of the resulting 3D CAD models with defects by automatically applying the appropriate boundary conditions. In this paper, we show a working proof-of-concept for the composite model builder with capabilities of incorporating delaminations between laminate layers and automatically preparing the CAD model for structural analysis using a FEA software.

  19. In-Situ NDE Characterization of Kevlar and Carbon Composite Micromechanics for Improved COPV Health Monitoring

    Science.gov (United States)

    Waller, Jess M.; Saulsberry, Regor L.

    2009-01-01

    This project is a subtask of a multi-center project to advance the state-of-the-art by developing NDE techniques that are capable of evaluating stress rupture (SR) degradation in Kevlar/epoxy (K/Ep) composite overwrapped pressure vessels (COPVs), and damage progression in carbon/epoxy (C/Ep) COPVs. In this subtask, acoustic emission (AE) data acquired during intermittent load hold tensile testing of K/Ep and C/Ep composite tow materials-of-construction used in COPV fabrication were analyzed to monitor progressive damage during the approach to tensile failure. Insight into the progressive damage of composite tow was gained by monitoring AE event rate, energy, source location, and frequency. Source location based on arrival time data was used to discern between significant AE attributable to microstructural damage and spurious AE attributable to background and grip noise. One of the significant findings was the observation of increasing violation of the Kaiser effect (Felicity ratio < 1.0) with damage accumulation.

  20. Development of beam current control system in RF-knockout slow extraction

    Science.gov (United States)

    Mizushima, K.; Sato, S.; Shirai, T.; Furukawa, T.; Katagiri, K.; Takeshita, E.; Iwata, Y.; Himukai, T.; Noda, K.

    2011-12-01

    A raster scanning method has been developed for cancer therapy at NIRS-HIMAC. This method requires a high-accuracy beam current control and fast beam-on/off switching. We have developed a feedback control system of the beam current with the RF-knockout slow extraction method. The system has allowed a stable response to beam-on/off switching using a feedback control delay function with a beam-current ripple of 7%.

  1. Development of beam current control system in RF-knockout slow extraction

    Energy Technology Data Exchange (ETDEWEB)

    Mizushima, K., E-mail: mizshima@nirs.go.jp [Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Graduate School of Science and Technology, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan); Sato, S.; Shirai, T.; Furukawa, T.; Katagiri, K.; Takeshita, E.; Iwata, Y.; Himukai, T.; Noda, K. [Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)

    2011-12-15

    A raster scanning method has been developed for cancer therapy at NIRS-HIMAC. This method requires a high-accuracy beam current control and fast beam-on/off switching. We have developed a feedback control system of the beam current with the RF-knockout slow extraction method. The system has allowed a stable response to beam-on/off switching using a feedback control delay function with a beam-current ripple of 7%.

  2. Forward propagation of parametric uncertainties through models of NDE inspection scenarios

    Science.gov (United States)

    Cherry, Matthew; Sabbagh, Harold; Aldrin, John; Knopp, Jeremy; Pilchak, Adam

    2015-03-01

    Forward uncertainty propagation has been a topic of interest to NDE researchers for several years. To this point, the purpose has been to gain an understanding of the uncertainties that can be seen in signals from NDE sensors given uncertainties in the geometric and material parameters of the problem. However, a complex analysis of an inspection scenario with high variability has not been performed. Furthermore, these methods have not seen direct practical application in the areas of model assisted probability of detection or inverse problems. In this paper, uncertainty due to spatial heterogeneity in material systems that undergo NDE inspection will be discussed. Propagation of this uncertainty through forward models of inspection scenarios will be outlined and the mechanisms for representing the spatial heterogeneity will be explained in detail. Examples will be provided that illustrate the effect of high variability in uncertainty propagation in the context of forward modeling.

  3. An NDE Approach for Characterizing Quality Problems in Polymer Matrix Composites

    Science.gov (United States)

    Roth, Don J.; Baaklini, George Y.; Sutter, James K.; Bodis, James R.; Leonhardt, Todd A.; Crane, Elizabeth A.

    1994-01-01

    Polymer matrix composite (PMC) materials are periodically identified appearing optically uniform but containing a higher than normal level of global nonuniformity as indicated from preliminary ultrasonic scanning. One such panel was thoroughly examined by nondestructive (NDE) and destructive methods to quantitatively characterize the nonuniformity. The NDE analysis of the panel was complicated by the fact that the panel was not uniformly thick. Mapping of ultrasonic velocity across a region of the panel in conjunction with an error analysis was necessary to (1) characterize properly the porosity gradient that was discovered during destructive analyses and (2) account for the thickness variation effects. Based on this study, a plan for future NDE characterization of PMC's is presented to the PMC community.

  4. Advanced defect detection algorithm using clustering in ultrasonic NDE

    Science.gov (United States)

    Gongzhang, Rui; Gachagan, Anthony

    2016-02-01

    A range of materials used in industry exhibit scattering properties which limits ultrasonic NDE. Many algorithms have been proposed to enhance defect detection ability, such as the well-known Split Spectrum Processing (SSP) technique. Scattering noise usually cannot be fully removed and the remaining noise can be easily confused with real feature signals, hence becoming artefacts during the image interpretation stage. This paper presents an advanced algorithm to further reduce the influence of artefacts remaining in A-scan data after processing using a conventional defect detection algorithm. The raw A-scan data can be acquired from either traditional single transducer or phased array configurations. The proposed algorithm uses the concept of unsupervised machine learning to cluster segmental defect signals from pre-processed A-scans into different classes. The distinction and similarity between each class and the ensemble of randomly selected noise segments can be observed by applying a classification algorithm. Each class will then be labelled as `legitimate reflector' or `artefacts' based on this observation and the expected probability of defection (PoD) and probability of false alarm (PFA) determined. To facilitate data collection and validate the proposed algorithm, a 5MHz linear array transducer is used to collect A-scans from both austenitic steel and Inconel samples. Each pulse-echo A-scan is pre-processed using SSP and the subsequent application of the proposed clustering algorithm has provided an additional reduction to PFA while maintaining PoD for both samples compared with SSP results alone.

  5. Structural assessment of metal foam using combined NDE and FEA

    Science.gov (United States)

    Ghosn, Louis J.; Abdul-Aziz, Ali; Young, Philippe G.; Rauser, Richard W.

    2005-05-01

    Metal foams are expected to find use in structural applications where weight is of particular concern, such as space vehicles, rotorcraft blades, car bodies or portable electronic devices. The obvious structural application of metal foam is for light weight sandwich panels, made up of thin solid face sheets and a metallic foam core. The stiffness of the sandwich structure is increased by separating the two face sheets by a light weight foam core. The resulting high-stiffness structure is lighter than that constructed only out of the solid metal material. Since the face sheets carry the applied in-plane and bending loads, the sandwich architecture is a viable engineering concept. However, the metal foam core must resist transverse shear loads and compressive loads while remaining integral with the face sheets. Challenges relating to the fabrication and testing of these metal foam panels remain due to some mechanical properties falling short of their theoretical potential. Theoretical mechanical properties are based on an idealized foam microstructure and assumed cell geometry. But the actual testing is performed on as fabricated foam microstructure. Hence in this study, a high fidelity finite element analysis is conducted on as fabricated metal foam microstructures, to compare the calculated mechanical properties with the idealized theory. The high fidelity geometric models for the FEA are generated using series of 2D CT scans of the foam structure to reconstruct the 3D metal foam geometry. The metal foam material is an aerospace grade precipitation hardened 17-4 PH stainless steel with high strength and high toughness. Tensile, compressive, and shear mechanical properties are deduced from the FEA model and compared with the theoretical values. The combined NDE/FEA provided insight in the variability of the mechanical properties compared to idealized theory.

  6. A circular aperture array for ultrasonic tomography and quantitative NDE

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, S.A.

    1998-08-01

    The main topics of this thesis are ultrasonic tomography and ultrasonic determination of elastic stiffness constants. Both issues are based on a synthetic array with transducer elements distributed uniformly along a circular aperture, i.e., a circular aperture array. The issues are treated both theoretically and experimentally by broadband pulse techniques. Ultrasonic tomography, UCT, from a circular aperture is a relatively new imaging technique in Non-destructive Evaluation (NDE) to acquire cross sectional images in bulk materials. A filtered back-projection algorithm is used to reconstruct images in four different experiments and results of attenuation, velocity and reflection tomograms in Plexiglas of AlSi-alloy cylinders are presented. Two kinds of ultrasonic tomography are introduced: bistatic and monostatic imaging. Both techniques are verified experimentally by Plexiglas cylinders. Different reconstruction artifacts are discussed and theoretical resolution constraints are discussed for various configurations of the circular aperture array. The monostatic technique is used in volumetric imaging. In the experimental verification artificial and real discontinuities in a cylindrical AlSi-alloy are compared with similar discontinuities in a Plexiglas specimen. Finally, some limitations to UCT are discussed. The circular aperture array is used to determine five independent elastic stiffness constants of a unidirectional glass/PET (Poly Ethylene Teraphtalate) laminate. Energy flux propagation and attenuation of ultrasonic waves are considered and velocity surfaces are calculated for different planes of interest. Relations between elastic stiffness constants and engineering constants (i.e., Young`s moduli, shear moduli and Poisson`s ratios) are discussed for an orthotropic composite. Six micromechanical theories are reviewed, and expressions predicting the elastic engineering constants are evaluated. The micromechanical predicted elastic stiffness constants for the

  7. Additive Manufacturing (AM) Activities and Non-Destructive Evaluation (NDE) at GSFC

    Science.gov (United States)

    Jones, Justin S.

    2017-01-01

    NASA personnel will be meeting with a delegation from the Japan Aerospace Exploration Agency (JAXA) Office of Safety and Mission Assurance (OSMA) at Langley Research Center on 2217 through 3217. The purpose of the meeting is a technical interchange between NASA and JAXA to discuss Non-Destructive Evaluation (NDE) of Additive Manufacturing (AM) parts and the HALT process (relates to accelerated life testing). The visitors will be a small group of Japanese citizens. Goddard Space Flight Center (GSFC) has been asked to participate in the meeting, either in person or via teleconference. This presentation covers NDE efforts at GSFC and provides a cursory overview of AM and lab capabilities.

  8. NDE of Fiber Reinforced Foam Composite Structures for Future Aerospace Vehicles

    Science.gov (United States)

    Walker, james; Roth, Don; Hopkins, Dale

    2010-01-01

    This slide presentation reviews the complexities of non-destructive evaluation (NDE) of fiber reinforced foam composite structures to be used for aerospace vehicles in the future.Various views of fiber reinforced foam materials are shown and described. Conventional methods of NDE for composites are reviewed such as Micro-computed X-Ray Tomography, Thermography, Shearography, and Phased Array Ultrasonics (PAUT). These meth0ods appear to work well on the face sheet and face sheet ot core bond, they do not provide adequate coverage for the webs. There is a need for additional methods that will examine the webs and web to foam core bond.

  9. Current Situations and Development Ideas of Buckwheat Tea Industry in Liangshan Prefecture

    Institute of Scientific and Technical Information of China (English)

    Fayong; GONG; Shiming; XIAO; Jing; LI

    2013-01-01

    This paper firstly introduces current situations of buckwheat tea industry in Liangshan Prefecture,current situations of intellectual property right of buckwheat tea in whole China,and total flavonoid content in buckwheat tea. On the basis of these current situations,it analyzes drawbacks of buckwheat tea sold in the market. Finally,it presents development ideas of buckwheat tea industry in Liangshan Prefecture.

  10. Colorado Plateau Rapid Ecoregion Assessment Change Agents - Development - Current, Near-Term, and Long-Term Potential High Landscape Development

    Data.gov (United States)

    Bureau of Land Management, Department of the Interior — This map shows areas of high current, near-term, and long-term potential landscape development, based on factors such as urban areas, agriculture, roads, and energy...

  11. Development and Characterization of Diamond Film and Compound Metal Surface High Current Photocathodes

    Science.gov (United States)

    Shurter, R. P.; Moir, D. C.; Shurter, R. P.; Moir, D. C.

    1997-05-01

    High current photocathodes operating in vacuum environments as high as 10-5 torr are being developed at Los Alamos for use in a new generation of linear induction accelerators. We report high quantum efficiencies and high current densities in wide bandgap semiconductor and compound metal surface thermally augmented photocathode materials illuminated by ultraviolet laser radiation.

  12. Development of voltage-dependent calcium, sodium, and potassium currents in Xenopus spinal neurons.

    Science.gov (United States)

    O'Dowd, D K; Ribera, A B; Spitzer, N C

    1988-03-01

    Action potentials of embryonic nerve and muscle cells often have a different ionic dependence and longer duration than those of mature cells. The action potential of spinal cord neurons from Xenopus laevis exhibits a prominent calcium component at early stages of development that diminishes with age as the impulse becomes principally sodium dependent. Whole-cell voltage-clamp analysis has been undertaken to characterize the changes in membrane currents during development of these neurons in culture. Four voltage-dependent currents of cells were identified and examined during the first day in vitro, when most of the change in the action potential occurs. There are no changes in the peak density of the calcium current (ICa), its voltage dependence, or time to half-maximal activation; a small increase in inactivation is apparent. The major change in sodium current (INa) is a 2-fold increase in its density. In addition, more subtle changes in the kinetics of the macroscopic sodium current were noted. The peak density of voltage-dependent potassium current (IKv) increases 3-fold, and this current becomes activated almost twice as fast. No changes were noted in the extent of its inactivation. The calcium-dependent potassium current (IKc) consists of an inactivating and a sustained component. The former increases 2-fold in peak current density, and the latter increases similarly at less depolarized voltages. The changes in these currents contribute to the decrease in duration and the change in ionic dependence of the impulse.

  13. Physical oceanography - Developing end-to-end models of the California Current Large Marine Ecosystem

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this project is to develop spatially discrete end-to-end models of the California Current LME, linking oceanography, biogeochemistry, food web...

  14. Atlantis model outputs - Developing end-to-end models of the California Current Large Marine Ecosystem

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this project is to develop spatially discrete end-to-end models of the California Current LME, linking oceanography, biogeochemistry, food web...

  15. Neutron radiography and other NDE tests of main rotor helicopter blades

    CSIR Research Space (South Africa)

    De Beer, FC

    2004-10-01

    Full Text Available leading to aircraft structural failures, are addressed by various NDE techniques. In a combined investigation by means of visual inspection, X-ray radiography and shearography on helicopter main rotor blades, neutron radiography (NRad) at SAFARI-1 research...

  16. Development of eddy current testing system using magnetic saturation in ferromagnetic materials

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Je Joong; Ahn, Hyung Keun; Shin, Yong Hoon [Sae An Engineering Corperation, Seoul (Korea, Republic of); Seo, Dong Man [Kunjang College, Kunsan (Korea, Republic of)

    2002-11-15

    Ferromagnetic materials have difficulties of eddy current test using traditional eddy current equipment due to their electric character of high permeability and anomalous magnetic flux. Development of on-line eddy current test equipment for ferromagnetic materials is a goal of this research. as the first step for it, in this paper, a prove for ferromagnetic materials was developed and practical test was performed with it at a manufactory. For magnetic saturation of inside of ferromagnetic material, DC power supply was used. As increasement of applied voltage, signals of defects were distinguished.

  17. Computational electromagnetics and model-based inversion a modern paradigm for eddy-current nondestructive evaluation

    CERN Document Server

    Sabbagh, Harold A; Sabbagh, Elias H; Aldrin, John C; Knopp, Jeremy S

    2013-01-01

    Computational Electromagnetics and Model-Based Inversion: A Modern Paradigm for Eddy Current Nondestructive Evaluation describes the natural marriage of the computer to eddy-current NDE. Three distinct topics are emphasized in the book: (a) fundamental mathematical principles of volume-integral equations as a subset of computational electromagnetics, (b) mathematical algorithms applied to signal-processing and inverse scattering problems, and (c) applications of these two topics to problems in which real and model data are used. By showing how mathematics and the computer can solve problems more effectively than current analog practices, this book defines the modern technology of eddy-current NDE. This book will be useful to advanced students and practitioners in the fields of computational electromagnetics, electromagnetic inverse-scattering theory, nondestructive evaluation, materials evaluation and biomedical imaging. Users of eddy-current NDE technology in industries as varied as nuclear power, aerospace,...

  18. Pressure tube replication techniques using the advanced NDE system

    Energy Technology Data Exchange (ETDEWEB)

    Isherwood, A.; Jarron, D.; Travers, J.; Hanley, K. [Ontario Power Generation, Pickering, Ontario (Canada)]. E-mail: andrew.isherwood@opg.com

    2006-07-01

    Periodic and in-service inspections of fuel channels are essential for the proper assessment of the structural integrity of these vital components. The arrival of new delivery devices for fuel channel inspections has driven new tooling for gathering and analyzing NDE data. The Advanced Non-Destructive Examination (ANDE) Replication System has been designed to compliment the ANDE Inspection System by providing a two plate replica system. These plates deliver a compound that makes a positive 3D mould of known ID flaws to gather information for flaw assessment. The two plate system, and the ability to retrieve and recharge the moulds in the reactor vault allows for gathering defect information with minimal critical path time. The ANDE Replication System was built on the foundation of CIGAR experience by a solid design team familiar with 3D CAD and manufacturing techniques. The tooling and controls went through a series of integration stages in the laboratory and then later with the Universal Delivery Machine (UDM) before being used on reactor starting in 2003. Once the inspection phase of an outage has been completed, the analysis team provides a list of flaw candidates that require 'root radius' information to complete the flaw assessment. This is a measure of how sharp the corners are in the defect. This data is used as part of the stress calculation that ultimately determines how many shutdown cycles that the reactor can have before that flaw must be re-inspected. The inspection tool is then swapped out of the delivery machine in the reactor vault using the versatile connectorized umbilical. The replication tool is loaded on the machine, charged with replica compound on each of the two plates, and then sent to the target channel(s). On channel, the operators use the same console as the ANDE Inspection System, but have a separate control system with a graphical display of the tool that shows its position in the channel with respect to the E-face. The axial

  19. Early detection of critical material degradation by means of electromagnetic multi-parametric NDE

    Energy Technology Data Exchange (ETDEWEB)

    Szielasko, Klaus; Tschuncky, Ralf; Rabung, Madalina; Altpeter, Iris; Dobmann, Gerd [Fraunhofer Institute for Nondestructive Testing (IZFP), Campus E3 1, 66123 Saarbrücken (Germany); Seiler, Georg; Herrmann, Hans-Georg; Boller, Christian [Fraunhofer Institute for Nondestructive Testing (IZFP), Campus E3 1, 66123 Saarbrücken, Germany and Saarland University, Chair of NDT and Quality Assurance, Campus E3 1, 66123 Saarbrücken (Germany)

    2014-02-18

    With an increasing number of power plants operated in excess of their original design service life an early recognition of critical material degradation in components will gain importance. Many years of reactor safety research allowed for the identification and development of electromagnetic NDE methods which detect precursors of imminent damage with high sensitivity, at elevated temperatures and in a radiation environment. Regarding low-alloy heat-resistant steel grade WB 36 (1.6368, 15NiCuMoNb5), effects of thermal and thermo-mechanical aging on mechanical-technological properties and several micromagnetic parameters have been thoroughly studied. In particular knowledge regarding the process of copper precipitation and its acceleration under thermo-mechanical load has been enhanced. Whilst the Cu-rich WB 36 steel is an excellent model material to study and understand aging effects related to neutron radiation without the challenge of handling radioactive specimens in a hot cell, actually neutron-irradiated reactor pressure vessel materials were investigated as well. The neutron fluence experienced and the resulting shift of the ductile-brittle transition temperature were determined electromagnetically, and it was shown that weld and base material can be distinguished from the cladded side of the RPV wall. Low-cycle fatigue of the austenitic stainless steel AISI 347 (1.4550, X6CrNiNb18-10) has been characterized with electromagnetic acoustic transducers (EMATs) at temperatures of up to 300 °C. Time-of-flight and amplitude of the transmitted ultrasound signal were evaluated against the number of load cycles applied and observed as an indication of the imminent material failure significantly earlier than monitoring stresses or strains.

  20. TERME DISTRICT DURING THE TANZIMAT PERIOD (TANZİMAT DÖNEMİ’NDE TERME KAZASI

    Directory of Open Access Journals (Sweden)

    İbrahim SERBESTOĞLU

    2016-11-01

    Full Text Available Özet Bu makalenin amacı Tanzimat Dönemi’nde yaşanan değişimin taşraya yansımasını Terme kazası üzerinden ortaya koymaktır. Tanzimat reformlarının uygulanması sürecinde Terme Kaza Meclisinde yerel güç odaklarının iktidar kavgaları yaşanmıştır. Bu kavgalar ekonomik güce sahip olma çabalarını ve yerel muhalefeti susturma girişimlerini beraberinde getirmiştir. Bununla birlikte tarımsal kalkınma ve küçük ölçekli sanayinin geliştirilmesi süreçleri de Tanzimat’ın kalkınma hamleleri olarak görülmüştür. Abstract This study examines the impact of Tanzimat reforms on the Ottoman periphery in general and in Terme District in particular. Terme, which was one of the districts of Canik Sanjak, had fertile lands. The article presents that the Tanzimat reforms triggered a power struggle among the local power centers in Terme Council for the control of local economy and led to attempts to silence the local dissidents. Despite this struggle, there were visible economic developments in both agriculture and small industry during the Tanzimat Period.

  1. Early detection of critical material degradation by means of electromagnetic multi-parametric NDE

    Science.gov (United States)

    Szielasko, Klaus; Tschuncky, Ralf; Rabung, Madalina; Seiler, Georg; Altpeter, Iris; Dobmann, Gerd; Herrmann, Hans-Georg; Boller, Christian

    2014-02-01

    With an increasing number of power plants operated in excess of their original design service life an early recognition of critical material degradation in components will gain importance. Many years of reactor safety research allowed for the identification and development of electromagnetic NDE methods which detect precursors of imminent damage with high sensitivity, at elevated temperatures and in a radiation environment. Regarding low-alloy heat-resistant steel grade WB 36 (1.6368, 15NiCuMoNb5), effects of thermal and thermo-mechanical aging on mechanical-technological properties and several micromagnetic parameters have been thoroughly studied. In particular knowledge regarding the process of copper precipitation and its acceleration under thermo-mechanical load has been enhanced. Whilst the Cu-rich WB 36 steel is an excellent model material to study and understand aging effects related to neutron radiation without the challenge of handling radioactive specimens in a hot cell, actually neutron-irradiated reactor pressure vessel materials were investigated as well. The neutron fluence experienced and the resulting shift of the ductile-brittle transition temperature were determined electromagnetically, and it was shown that weld and base material can be distinguished from the cladded side of the RPV wall. Low-cycle fatigue of the austenitic stainless steel AISI 347 (1.4550, X6CrNiNb18-10) has been characterized with electromagnetic acoustic transducers (EMATs) at temperatures of up to 300 °C. Time-of-flight and amplitude of the transmitted ultrasound signal were evaluated against the number of load cycles applied and observed as an indication of the imminent material failure significantly earlier than monitoring stresses or strains.

  2. Transient Eddy Current Response Due to a Subsurface Crack in a Conductive Plate

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Fangwei [Iowa State Univ., Ames, IA (United States)

    2006-01-01

    Eddy current nondestructive evaluation (NDE) is usually carried out by exciting a time harmonic field using an inductive probe. However, a viable alternative is to use transient eddy current NDE in which a current pulse in a driver coil produces a transient .eld in a conductor that decays at a rate dependent on the conductivity and the permeability of the material and the coil configuration. By using transient eddy current, it is possible to estimate the properties of the conductive medium and to locate and size potential .aws from the measured probe response. The fundamental study described in this dissertation seeks to establish a theoretical understanding of the transient eddy current NDE. Compared with the Fourier transform method, the derived analytical formulations are more convenient when the transient eddy current response within a narrow time range is evaluated. The theoretical analysis provides a valuable tool to study the effect of layer thickness, location of defect, crack opening as well as the optimization of probe design. Analytical expressions have been developed to evaluate the transient response due to eddy currents in a conductive plate based on two asymptotic series. One series converges rapidly for a short time regime and the other for a long time regime and both of them agree with the results calculated by fast Fourier transform over all the times considered. The idea of asymptotic expansion is further applied to determine the induced electromotive force (EMF) in a pick-up coil due to eddy currents in a cylindrical rod. Starting from frequency domain representation, a quasi-static time domain dyadic Green's function for an electric source in a conductive plate has been derived. The resulting expression has three parts; a free space term, multiple image terms and partial reflection terms. The dyadic Green's function serves as the kernel of an electric field integral equation which defines the interaction of an ideal crack with the

  3. Current situation of Chinese forestry tactics and strategy of sustainable development

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Based on the analysis of the current situation of Chinese forestry and aseries of ecological, environmental, economic, and social problems, this paper emphasized on the importance of forests in social and economic development in China The author pointed out that sustainable development, particularly the sustainable development of forestry, is the inevitable choice to solve the problems of ecological environment and social economics. The objectives, criteria, and strategies of sustaining forestry were also demonstrated and expounded, from the viewpoints of ecology, economics, and sociology.

  4. Current Development Situations of Ziziphus Jujuba Industry in South Xinjiang and Recommendations

    Institute of Scientific and Technical Information of China (English)

    Xinwen; JIN; Xuedong; YAO; Chengjiang; LIU; Hai; LIN; Zheng; LOU; Zhenjiang; GAO

    2015-01-01

    Through surveying current development situations and existing problems of planting and processing of Ziziphus jujuba in south Xinjiang,this paper discussed planting,processing mode of Ziziphus Jujuba in south Xinjiang and development direction of enterprises in Ziziphus Jujuba production. It is expected to ensure and increase quality and sales volume of Ziziphus Jujuba and promote sound and sustainable development of Ziziphus Jujuba industrial chain in south Xinjiang.

  5. Development of a Multi-Site and Multi-Device Webgis-Based Tool for Tidal Current Energy Development

    Science.gov (United States)

    Ang, M. R. C. O.; Panganiban, I. K.; Mamador, C. C.; De Luna, O. D. G.; Bausas, M. D.; Cruz, J. P.

    2016-06-01

    A multi-site, multi-device and multi-criteria decision support tool designed to support the development of tidal current energy in the Philippines was developed. Its platform is based on Geographic Information Systems (GIS) which allows for the collection, storage, processing, analyses and display of geospatial data. Combining GIS tools with open source web development applications, it becomes a webGIS-based marine spatial planning tool. To date, the webGIS-based tool displays output maps and graphs of power and energy density, site suitability and site-device analysis. It enables stakeholders and the public easy access to the results of tidal current energy resource assessments and site suitability analyses. Results of the initial development showed that it is a promising decision support tool for ocean renewable energy project developments.

  6. Analysis of the status’current situation and reflection on the development of circular economy

    Institute of Scientific and Technical Information of China (English)

    翟程

    2013-01-01

    It is the mainstream of the times building a moderately prosperous society, build a harmonious home, guiding eco-nomic development with scientific Outlook on Development. It is the objective requirements of social development, current more and more prominent, ecological construction and environmental protection increasingly grim situation along with Chi-na's rapid economic growth and increasing population, water, land, mineral, etc. like this it is particularly important and urgent. According to the scientific development concept, vigorously develop the circular economy;accelerate the establishment of a resource-saving society.

  7. Wireless Self-powered Visual and NDE Robotic Inspection System for Live Gas Distribution Mains

    Energy Technology Data Exchange (ETDEWEB)

    Susan Burkett; Hagen Schempf

    2006-01-31

    recovery of the system using custom fittings and a (to be developed) launch-chamber/-tube. The battery modules are used to power the system, by providing power to the robot's bus. The support modules perform the functions of centration for the rest of the train as well as odometry pickups using incremental encoding schemes. The electronics architecture is based on a distributed (8-bit) microprocessor architecture (at least 1 in ea. module) communicating to a (one of two) 32-bit SBC, which manages all video-processing, posture and motion control as well as CAN and wireless communications. The operator controls the entire system from an off-board (laptop) controller, which is in constant wireless communication with the robot train in the pipe. The sensor modules collect data and forward it to the robot operator computer (via the CAN-wireless communications chain), who then transfers it to a dedicated NDE data-storage and post-processing computer for further (real-time or off-line) analysis. CMU has fully designed every module in terms of the mechanical, electrical and software elements (architecture only). Substantial effort has gone into pre-prototyping to uncover mechanical, electrical and software issues for critical elements of the design. Design requirements for sensor-providers were also detailed and finalized and provided to them for inclusion in their designs. CMU is expecting to start 2006 with a detailed design effort for both mechanical and electrical components, followed by procurement and fabrication efforts in late winter/spring 2006. The assembly and integration efforts will occupy all of the spring and summer of 2006. Software development will also be a major effort in 2006, and will result in porting and debugging of code on the module- and train-levels in late summer and Fall of 2006. Final pipe mock-up testing is expected in late fall and early winter 2006 with an acceptance demonstration of the robot train (with a sensor-module mock-up) planned to Do

  8. Development and evaluation of an automated system for testing current meters

    Directory of Open Access Journals (Sweden)

    Ezequiel Saretta

    2016-02-01

    Full Text Available ABSTRACT Current meters are equipment widely used for estimating flow velocity in rivers and streams. Periodic calibrations of current meters are important to ensure the quality of measurements, but the required testing facilities are complex and only available in a few institutions. However, advances in electronics and automation may contribute to developing simple and reliable calibration systems. Thus, this study aimed to develop an automated system for testing current meters, which consisted of a trapezoidal channel, a step motor, a tow car and a management system, composed of a supervisory application and microprocessed modules to control the motor and the data acquisition. Evaluations of the displacement velocity showed that it matched the reference value up to 1.85 m s-1 for a vertical-axis current meter and 2.3 m s-1 for a horizontal-axis one. The developed system showed reliability during tests, for both current meter movement and data acquisition. The management of the system based on the developed modules and the supervisory application improved its user interface, turning all the procedure into a simple task.

  9. Remote Welding, NDE and Repair of DOE Standardized Canisters

    Energy Technology Data Exchange (ETDEWEB)

    Eric Larsen; Art Watkins; Timothy R. McJunkin; Dave Pace; Rodney Bitsoi

    2006-05-01

    The U.S. Department of Energy (DOE) created the National Spent Nuclear Fuel Program (NSNFP) to manage DOE’s spent nuclear fuel (SNF). One of the NSNFP’s tasks is to prepare spent nuclear fuel for storage, transportation, and disposal at the national repository. As part of this effort, the NSNFP developed a standardized canister for interim storage and transportation of SNF. These canisters will be built and sealed to American Society of Mechanical Engineers (ASME) Section III, Division 3 requirements. Packaging SNF usually is a three-step process: canister loading, closure welding, and closure weld verification. After loading SNF into the canisters, the canisters must be seal welded and the welds verified using a combination of visual, surface eddy current, and ultrasonic inspection or examination techniques. If unacceptable defects in the weld are detected, the defective sections of weld must be removed, re-welded, and re-inspected. Due to the high contamination and/or radiation fields involved with this process, all of these functions must be performed remotely in a hot cell. The prototype apparatus to perform these functions is a floor-mounted carousel that encircles the loaded canister; three stations perform the functions of welding, inspecting, and repairing the seal welds. A welding operator monitors and controls these functions remotely via a workstation located outside the hot cell. The discussion describes the hardware and software that have been developed and the results of testing that has been done to date.

  10. Development of electric currents in a magnetic field configuration containing a magnetic null point

    Science.gov (United States)

    Santos, J. C.; Büchner, J.; Otto, A.

    2011-01-01

    Context. In the past the role of magnetic null points in the generation of electric currents was investigated mainly in the close vicinity of the null, with perturbations being applied at nearby boundaries, or for a magnetic null configuration with a dome-shaped fan. In the solar atmosphere, however, electric currents are generated by perturbations originating at the photosphere, far away from coronal 3D nulls, and the occurence of magnetic nulls with a dome-shaped fan is apparently not common. Aims: We investigate the consequences of photospheric motion for the development of electric currents in a coronal magnetic field configuration containing a null, located far away from the boundaries, and the influence of topological structures on the spatial distribution of the currents. Methods: We use a 3D resistive MHD code to investigate the consequences of photospheric plasma motion for the generation of currents in a coronal magnetic field containing a null. The plasma is considered fully compressible and is initially in hydrostatic equilibrium. The initial magnetic field is potential (current free). Results: The photospheric plasma motion causes magnetic field perturbations that propagate to the corona along the field lines at the local Alfvén speed. The Alfvénic wave perturbations correspond to a propagating current directed mainly parallel to the magnetic field. Perpendicular currents connect to return currents to close the current system. The magnetic perturbations eventually reach the vicinity of the null. However, the currents forming in and around the null, near the fan surface or near the spine field lines, are not always the strongest currents developing in the simulation box. In our simulation, the strongest currents develop close to the bottom boundary, where the plasma is moved, and below the null point, in a region where field line connectivity considerably changes. Conclusions: Our simulation shows that the presence of a magnetic null point does not

  11. A scaleable integrated sensing and control system for NDE, monitoring, and control of medium to very large composite smart structures

    Science.gov (United States)

    Jones, Jerry; Rhoades, Valerie; Arner, Radford; Clem, Timothy; Cuneo, Adam

    2007-04-01

    NDE measurements, monitoring, and control of smart and adaptive composite structures requires that the central knowledge system have an awareness of the entire structure. Achieving this goal necessitates the implementation of an integrated network of significant numbers of sensors. Additionally, in order to temporally coordinate the data from specially distributed sensors, the data must be time relevant. Early adoption precludes development of sensor technology specifically for this application, instead it will depend on the ability to utilize legacy systems. Partially supported by the U.S. Department of Commerce, National Institute of Standards and Technology, Advanced Technology Development Program (NIST-ATP), a scalable integrated system has been developed to implement monitoring of structural integrity and the control of adaptive/intelligent structures. The project, called SHIELD (Structural Health Identification and Electronic Life Determination), was jointly undertaken by: Caterpillar, N.A. Tech., Motorola, and Microstrain. SHIELD is capable of operation with composite structures, metallic structures, or hybrid structures. SHIELD consists of a real-time processing core on a Motorola MPC5200 using a C language based real-time operating system (RTOS). The RTOS kernel was customized to include a virtual backplane which makes the system completely scalable. This architecture provides for multiple processes to be operating simultaneously. They may be embedded as multiple threads on the core hardware or as separate independent processors connected to the core using a software driver called a NAT-Network Integrator (NATNI). NATNI's can be created for any communications application. In it's current embodiment, NATNI's have been created for CAN bus, TCP/IP (Ethernet) - both wired and 802.11 b and g, and serial communications using RS485 and RS232. Since SHIELD uses standard C language, it is easy to port any monitoring or control algorithm, thus providing for legacy

  12. The development of safe high current operation in JET-ILW

    Energy Technology Data Exchange (ETDEWEB)

    Rimini, Fernanda G., E-mail: fernanda.rimini@ccfe.ac.uk [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Alves, Diogo [Instituto de Plasmas e Fusão Nuclear, IST, Universidade de Lisboa (Portugal); Arnoux, Gilles [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Baruzzo, Matteo [Associazione EURATOM-ENEA sulla Fusione, Consorzio RFX Padova (Italy); Belonohy, Eva [Max-Planck-Institut für Plasmaphysik, 85748 Garching (Germany); Carvalho, Ivo [Instituto de Plasmas e Fusão Nuclear, IST, Universidade de Lisboa (Portugal); Felton, Robert [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Joffrin, Emmanuel [IRFM-CEA, Centre de Cadarache, 13108 Sant-Paul-lez-Durance (France); Lomas, Peter; McCullen, Paul [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Neto, Andre [Fusion for Energy, 08019 Barcelona (Spain); Nunes, Isabel [Instituto de Plasmas e Fusão Nuclear, IST, Universidade de Lisboa (Portugal); Reux, Cedric [IRFM-CEA, Centre de Cadarache, 13108 Sant-Paul-lez-Durance (France); Stephen, Adam; Valcarcel, Daniel [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Wiesen, Sven [IEK-4, Forschungszentrum Jüulich GmbH, Partner in the Trilateral Euregio Cluster, Juelich (Germany)

    2015-10-15

    Highlights: • JET is unique in its capability to operate in DT and at high plasma current. • Studies of high current H-mode are integral part of JET ITER-like Wall programme. • Focus is on safety wrt transient & steady-state heat loads on ILW components. • Early real-time detection of off-normal events and disruption effects mitigation. • This work successfully delivered H-mode scenario up to 4 MA. - Abstract: The JET tokamak is unique amongst present fusion devices in its capability to operate at high plasma current, providing the closest plasma parameters to ITER. The physics benefits of high current operation have to be balanced against the risks to the integrity of the machine due to high force disruptions. The installation of the ITER-Like Wall (ILW) has added risks due to the thermal characteristics of the metal Plasma Facing Components. This paper describes the operational aspects of the scientific development of high current H-mode plasmas with the ILW, focusing on disruption prediction, avoidance and amelioration. The development yielded baseline H-mode plasmas up to 4 MA/3.74 T, comparable to the maximum current achieved in JET in Carbon-Wall (CFC) conditions with similar divertor geometry.

  13. Development of a Direct Methanol Fuel Cell with Lightweight Disc Type Current Collectors

    Directory of Open Access Journals (Sweden)

    Yean-Der Kuan

    2014-05-01

    Full Text Available The direct methanol fuel cell (DMFC adopts methanol solution as a fuel suitable for low power portable applications. A miniature, lightweight, passive air-breathing design is therefore desired. This paper presents a novel planar disc-type DMFC with multiple cells containing a novel developed lightweight current collector at both the anode and cathode sides. The present lightweight current collector adopts FR4 Glass/Epoxy as the substrate with the current collecting areas located at the corresponding membrane electrolyte assembly (MEA areas. The current collecting areas are fabricated by sequentially coating a corrosion resistant layer and electrical conduction layer via the thermal evaporation technique. The anode current collector has carved flow channels for fuel transport and production. The cathode current collector has drilled holes for passive air breathing. In order to ensure feasibility in the present concept a 3-cell prototype DMFC module with lightweight disc type current collectors is designed and constructed. Experiments were conducted to measure the cell performance. The results show that the highest cell power output is 54.88 mW·cm−2 and successfully demonstrate the feasibility of this novel design.

  14. Current Status and Future Strategies for Development of Transgenic Plants in China

    Institute of Scientific and Technical Information of China (English)

    De-Ping Wang

    2007-01-01

    In this review, the author summarized the current status, challenges, and strategies in China in the development of transgenic plants and its commercialization. Based on sets of successful examples and data achieved from execution of the National Special Project for Transgenic Plant Research and Commercialization in the last five years, the priorities and key directions were put forward for the future development of transgenic plants in China.

  15. Current developments with TRIUMF’s titanium-sapphire laser based resonance ionization laser ion source

    Energy Technology Data Exchange (ETDEWEB)

    Lassen, J., E-mail: LASSEN@triumf.ca; Li, R. [TRIUMF (Canada); Raeder, S. [GSI Helmholtzzentrum für Schwerionenforschung GmbH (Germany); Zhao, X.; Dekker, T. [TRIUMF (Canada); Heggen, H. [GSI Helmholtzzentrum für Schwerionenforschung GmbH (Germany); Kunz, P.; Levy, C. D. P.; Mostanmand, M.; Teigelhöfer, A.; Ames, F. [TRIUMF (Canada)

    2017-11-15

    Developments at TRIUMF’s isotope separator and accelerator (ISAC) resonance ionization laser ion source (RILIS) in the past years have concentrated on increased reliability for on-line beam delivery of radioactive isotopes to experiments, as well as increasing the number of elements available through resonance ionization and searching for ionization schemes with improved efficiency. The current status of these developments is given with a list of two step laser ionization schemes implemented recently.

  16. Development and characterization of diamond film and compound metal surface high current photocathodes

    Energy Technology Data Exchange (ETDEWEB)

    Shurter, R.P.; Moir, D.C.; Devlin, D.J.; Springer, R.W.; Archuleta, T.A.

    1997-09-01

    High current photocathodes operating in vacuum environments as high as 8xE-5 torr are being developed at Los Alamos for use in a new generation of linear induction accelerators. We report quantum efficiencies in wide bandgap semiconductors, pure metals, and compound metal surfaces photocathode materials illuminated by ultraviolet laser radiation.

  17. Development of a Computerized Current Awareness Service Using "Chemical Abstracts" Condensates

    Science.gov (United States)

    Roberts, Anita B.; And Others

    1972-01-01

    The experiences in developing current awareness services for selective dissemination of information from Chemical Abstracts'' Condensates data base are described. File standardization, the weighted-term method of searching, and the algorithm used to perform the search on the CDC 6600 computer and a user survey are discussed. (2 references)…

  18. ⁹⁰Y Hepatic Radioembolization : An Update on Current Practice and Recent Developments

    NARCIS (Netherlands)

    Braat, Arthur J A T; Smits, Maarten L J; Braat, Manon N G J A; van den Hoven, Andor; Prince, Jip F; de Jong, Hugo W A M; van den Bosch, Maurice A A J; Lam, Marnix G E H

    2015-01-01

    Radioembolization is an established treatment modality that has been subjected to many improvements over the last decade. Developments are occurring at a high pace, affecting patient selection and treatment. The aim of this review is therefore to provide an overview of current practice, with a focus

  19. Research on the Child Development Project: Current Status and Future Directions.

    Science.gov (United States)

    Battistich, Victor; Solomon, Daniel

    1989-01-01

    Reports on the current status of the Child Development Project (San Ramon, California). States that major concerns focus upon validity of measures and criterion validity. Notes that there are indications that the program is being implemented and children's attitudes are being affected. Predicts additional teacher questionnaire measures and the…

  20. Neural-Net Based Optical NDE Method for Structural Health Monitoring

    Science.gov (United States)

    Decker, Arthur J.; Weiland, Kenneth E.

    2003-01-01

    This paper answers some performance and calibration questions about a non-destructive-evaluation (NDE) procedure that uses artificial neural networks to detect structural damage or other changes from sub-sampled characteristic patterns. The method shows increasing sensitivity as the number of sub-samples increases from 108 to 6912. The sensitivity of this robust NDE method is not affected by noisy excitations of the first vibration mode. A calibration procedure is proposed and demonstrated where the output of a trained net can be correlated with the outputs of the point sensors used for vibration testing. The calibration procedure is based on controlled changes of fastener torques. A heterodyne interferometer is used as a displacement sensor for a demonstration of the challenges to be handled in using standard point sensors for calibration.

  1. Schnelles semi-quantitatives Screening auf Antibiotikarückstände in Fleisch

    OpenAIRE

    2016-01-01

    In dieser Arbeit wurde der ursprünglich für den Antibiotika-Nachweis in Milch entwickelte Biosensor MCR3 für das Screening von Fleischproben auf Hemmstoffrückstände in Fleisch evaluiert, adaptiert, validiert und mit hemmstoffhaltigen Proben aus der Routinepraxis erfolgreich getestet. Die orientierende Evaluierung der Antikörper-basierten Einzelnachweise zeigte, dass in Pufferlösung alle implementierten Antibiotika (Penicillin G, Cloxacillin, Nafcillin, Cephapirin, Ceftiofur, Gentamicin, Ne...

  2. Assessment of NDE Methods to Detect Lack of Fusion in HDPE Butt Fusion Joints

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, Susan L.; Doctor, Steven R.; Cinson, Anthony D.; Watts, Michael W.; Moran, Traci L.; Anderson, Michael T.

    2011-07-31

    Studies at the Pacific Northwest National Laboratory (PNNL) in Richland, Washington, were conducted to evaluate nondestructive examinations (NDE) coupled with mechanical testing of butt fusion joints in high-density polyethylene (HDPE) pipe for assessing lack of fusion. The work provided information to the United States Nuclear Regulatory Commission (NRC) on the effectiveness of volumetric inspection techniques of HDPE butt fusion joints in Section III, Division 1, Class 3, buried piping systems in nuclear power plants. This paper describes results from assessments using ultrasonic and microwave nondestructive techniques and mechanical testing with the high-speed tensile impact test and the side-bend test for determining joint integrity. A series of butt joints were fabricated in 3408, 12-inch (30.5-cm) IPS DR-11 HDPE material by varying the fusion parameters to create good joints and joints containing a range of lack-of-fusion conditions. Six of these butt joints were volumetrically examined with time-of-flight diffraction (TOFD), phased-array (PA) ultrasound, and the Evisive microwave system. The outer diameter (OD) weld beads were removed for microwave evaluation and the pipes ultrasonically re-evaluated. In two of the six pipes, both the outer and inner diameter (ID) weld beads were removed and the pipe joints re-evaluated. Some of the pipes were sectioned and the joints destructively evaluated with the high-speed tensile test and the side-bend test. The fusion parameters, nondestructive and destructive evaluation results have been correlated to validate the effectiveness of what each NDE technology detects and what each does not detect. There was no single NDE method that detected all of the lack-of-fusion flaws but a combination of NDE methods did detect most of the flaws.

  3. A Comparison of NDE Methods for Inspection of Composite Ceramic Armor

    Science.gov (United States)

    2010-03-10

    NDE modalities under present study include: 1)-immersion phased array ultrasonics , 2)- through-transmission, direct-digital x-ray imaging, 3)-non...methods under evaluation include: 1)-immersion phased array ultrasonics , 2)- through- transmission, direct-digital x-ray imaging, 3)-non-contact scanning...include: 1)-immersion phased array ultrasonics , 2)- through-transmission, direct-digital x-ray imaging, 3)-non-contact scanning microwaves, 4)-air

  4. Directed Design of Experiments (DOE) for Determining Probability of Detection (POD) Capability of NDE Systems (DOEPOD)

    Science.gov (United States)

    Generazio, Ed

    2007-01-01

    This viewgraph presentation reviews some of the issues that people who specialize in Non destructive evaluation (NDE) have with determining the statistics of the probability of detection. There is discussion of the use of the binominal distribution, and the probability of hit. The presentation then reviews the concepts of Directed Design of Experiments for Validating Probability of Detection of Inspection Systems (DOEPOD). Several cases are reviewed, and discussed. The concept of false calls is also reviewed.

  5. Micromechanical Models for Composite NDE and Diagnostics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Modern aircraft increasingly rely on composite components, due to their excellent material properties. However, fastening/joining and design methodologies in current...

  6. Concept development and numerical analysis of tokamak heating and current drive

    Energy Technology Data Exchange (ETDEWEB)

    Ju, Myung Hee; Hong, Bong Guen [Korea Atomic Energy Research Institute, Taejon (Korea)

    1998-10-01

    We have done the analytical study on the coupling between the KSTAR plasma and RF antenna necessary for the engineering design of the KSTAR auxiliary heating and current drive system as well as the KSTAR RF antenna. With the code TORIC, the possible parameter ranges of tokamak heating and current drive operation modes using fast wave on the KSTAR are defined and analyzed. The optimized operation scenarios corresponding to the variety of KSTAR fast wave-driven heating and current drive parameters are also developed. With the code RANT3D, the characteristics of the coupling between the KSTAR plasma and RF antenna are analyzed, and the data for the conceptual design of 6 MW KSTAR RF antenna are achieved. Finally the optimum heating and current drive scenarios for the 3 KSTAR operation modes (the baseline reference mode, the upgrade reference mode, the reverse shear mode) using ACCOME and WHIST are developed, and it was shown that they can be realized in KSTAR tokamak with the planned heating and current drive systems. (author). 20 refs., 39 figs., 3 tabs.

  7. Detection and sizing of defects in control rod drive mechanism penetrations using eddy current and ultrasonics

    Energy Technology Data Exchange (ETDEWEB)

    Light, G.M.; Fisher, J.L.; Tennis, R.F.; Stolte, J.S.; Hendrix, G.J. [Southwest Research Inst., San Antonio, TX (United States)

    1996-08-01

    Over the last two years, concern has been generated about the capabilities of performing nondestructive evaluation (NDE) of the closure-head penetrations in nuclear-reactor pressure vessels. These penetrations are primarily for instrumentation and control rod drive mechanisms (CRDMs) and are usually thick-walled Inconel tubes, which are shrink-fitted into the steel closure head. The penetrations are then welded between the outside surface of the penetration and the inside surface of the closure head. Stress corrosion cracks initiating at the inner surface of the penetration have been reported at several plants. Through-wall cracks in the CRDM penetration or CRDM weld could lead to loss of coolant in the reactor vessel. The CRDM penetration presents a complex inspection geometry for conventional NDE techniques. A thermal sleeve, through which pass the mechanical linkages for operating the control rods, is inserted into the penetration in such a way that only a small annulus (nominally 3 mm) exists between the thermal sleeve and inside surface of the penetration. Ultrasonic (UT) and eddy current testing (ET) techniques that could be used to provide defect detection and sizing capability were investigated. This paper describes the ET and UT techniques, the probes developed, and the results obtained using these probes and techniques on CRDM penetration mock-ups.

  8. Application of Hilbert-Huang Transform for Improved Defect Detection in Terahertz NDE of Shuttle Tiles

    Science.gov (United States)

    Anastasi, Robert F.; Madaras, Eric I.

    2005-01-01

    Terahertz NDE is being examined as a method to inspect the adhesive bond-line of Space Shuttle tiles for defects. Terahertz signals are generated and detected, using optical excitation of biased semiconductors with femtosecond laser pulses. Shuttle tile samples were manufactured with defects that included repair regions unbond regions, and other conditions that occur in Shuttle structures. These samples were inspected with a commercial terahertz NDE system that scanned a tile and generated a data set of RF signals. The signals were post processed to generate C-scan type images that are typically seen in ultrasonic NDE. To improve defect visualization the Hilbert-Huang Transform, a transform that decomposes a signal into oscillating components called intrinsic mode functions, was applied to test signals identified as being in and out of the defect regions and then on a complete data set. As expected with this transform, the results showed that the decomposed low-order modes correspond to signal noise while the high-order modes correspond to low frequency oscillations in the signal and mid-order modes correspond to local signal oscillations. The local oscillations compare well with various reflection interfaces and the defect locations in the original signal.

  9. Role of tonic GABAergic currents during pre- and early postnatal rodent development

    Directory of Open Access Journals (Sweden)

    Werner eKilb

    2013-09-01

    Full Text Available In the last three decades it became evident that the GABAergic system plays an essential role for the development of the central nervous system, by influencing the proliferation of neuronal precursors, neuronal migration and differentiation, as well as by controlling early activity patterns and thus formation of neuronal networks. GABA controls neuronal development via depolarizing membrane responses upon activation of ionotropic GABA receptors. However, many of these effects occur before the onset of synaptic GABAergic activity and thus require the presence of extrasynaptic tonic currents in neuronal precursors and immature neurons. This review summarizes our current knowledge about the role of tonic GABAergic currents during early brain development. In this review we compare the temporal sequence of the expression and functional relevance of different GABA receptor subunits, GABA synthesizing enzymes and GABA transporters. We also refer to other possible endogenous agonists of GABAA receptors. In addition, we describe functional consequences mediated by the GABAergic system during early developmental periods and discuss current models about the origin of extrasynaptic GABA and/or other endogenous GABAergic agonists during early developmental states. Finally, we present evidence that tonic GABAergic activity is also critically involved in the generation of physiological as well as pathophysiological activity patterns before and after the establishment of functional GABAergic synaptic connections.

  10. Role of tonic GABAergic currents during pre- and early postnatal rodent development.

    Science.gov (United States)

    Kilb, Werner; Kirischuk, Sergei; Luhmann, Heiko J

    2013-01-01

    In the last three decades it became evident that the GABAergic system plays an essential role for the development of the central nervous system, by influencing the proliferation of neuronal precursors, neuronal migration and differentiation, as well as by controlling early activity patterns and thus formation of neuronal networks. GABA controls neuronal development via depolarizing membrane responses upon activation of ionotropic GABA receptors. However, many of these effects occur before the onset of synaptic GABAergic activity and thus require the presence of extrasynaptic tonic currents in neuronal precursors and immature neurons. This review summarizes our current knowledge about the role of tonic GABAergic currents during early brain development. In this review we compare the temporal sequence of the expression and functional relevance of different GABA receptor subunits, GABA synthesizing enzymes and GABA transporters. We also refer to other possible endogenous agonists of GABAA receptors. In addition, we describe functional consequences mediated by the GABAergic system during early developmental periods and discuss current models about the origin of extrasynaptic GABA and/or other endogenous GABAergic agonists during early developmental states. Finally, we present evidence that tonic GABAergic activity is also critically involved in the generation of physiological as well as pathophysiological activity patterns before and after the establishment of functional GABAergic synaptic connections.

  11. Current Development Situations and Countermeasures for Tobacco Farmers’ Specialized Cooperatives in Hunan Province

    Institute of Scientific and Technical Information of China (English)

    Xinbin; LUO; Jianqiang; XU

    2013-01-01

    This paper firstly introduces development history of China’s farmers’ specialized cooperatives and connotation and mechanism of tobacco farmers’ specialized cooperatives. Then, it analyzes current development situations of tobacco farmers’ specialized cooperatives in Hunan Province. On the basis of analysis, it puts forward development countermeasures, including realizing circulation of tobacco land, strengthening propaganda of laws on tobacco farmers’ specialized cooperatives, increasing operation effect of tobacco farmers’ specialized cooperatives, enhancing guidance and supervision of tobacco farmers’ specialized cooperatives, as well as improving specialized service level.

  12. Antimicrobial peptides as parasiticidal against human trypanosomatids: mechanisms of action and current status in development.

    Science.gov (United States)

    Méndez-Samperio, P; de-la-Rosa-Arana, J L

    2013-04-01

    Trypanosomes cause a variety of tropical diseases that affect the livelihood of individuals worldwide. The currently used pharmaceutical treatments rely on chemotherapy. However, many of these drugs are very expensive, and highly toxic. In addition, parasite resistance to several of the therapeutic drugs used is increasing. Therefore, there is a growing need for new control measures for many of these diseases. One new approach is the use of antimicrobial peptides (AMPs) to disease control, since these peptides can be used as potential anti-parasite effector molecules. This review summarizes and discusses the parasiticidal properties of AMPs for treating trypanosome infections, highlighting their mechanisms of action and current status in development.

  13. Open Augmented Reality Standards: Current Activities in Standards- Development Organizations%Open Augmented Reality Standards: Current Activities in Standards- Development Organizations

    Institute of Scientific and Technical Information of China (English)

    Christine Perey

    2012-01-01

    Augmented reality (AR) has emerged from research laboratories and is now being accepted in other domains as an attractive way of visualizing information. Before AR can be used in the mass market, there are a number of obstacles that need to be overcome. Several of these can be overcome by adopting open standards. A global grassroots community seeking open, interoperable AR content and experiences began to take shape in early 2010. This community is working collaboratively to reduce the barriers to the flow of data from content provider to AR end user. Standards development organizations and industry groups that provide open interfaces for AR meet regularly to provide updates, identify complementary work, and seek harmonization. The community also identifies deployer and implementer needs, communicates requirements, and discusses emerging challenges that could be resolved with standards. In this article, we describe current activities in international standards-development organizations. We summarize the AR standards gap analysis and shed light on special considerations for using standards in mobile AR.

  14. Development of a 600 A HTS current lead using modular design

    CERN Document Server

    Scheller, L; Werfel, F; Gehring, M

    2002-01-01

    The paper reports about the development and fabrication of a 600 A HTS current lead prototype. Main focus of this task was an economic and robust design. Thus we used a fiberglass housing, also providing electrical insulation, replaceable parts and common soldering technology. The HTS part was made from an YBCO bar fabricated according to the ATZ in-house Ceramo Crystal Growth technology. Due to mechanical reasons and to reach a sufficient low contact resistance, a bar had to be used which had a far higher transport current carrying capability than the required 600 A. The measurements at low temperatures showed, that the chosen design is suitable for application. Especially advantages for high current applications can be expected. (3 refs).

  15. Current status and future prospects of the development of clinical Pharmacy in China: A SWOT analysis.

    Science.gov (United States)

    Rao, Yuefeng; Zhao, Qingwei; Zhang, Xiangyi; Yang, Hongyu; Lou, Yan; Zhang, Xingguo

    2016-03-01

    In many industrialized countries, clinical pharmacy has developed into a separate discipline and become a vital part of inpatient care in hospitals. However, as compared to many established branches of medicine, clinical pharmacy is still in its infancy, with much room for growth, improvement, and recognition by both the medical community and patients. In this study, a widely-recognized development strategy analysis tool, Strength, Weakness, Opportunity and Threat (SWOT), was used to systematically address several key issues to the development of clinical pharmacy in China. This analysis aims to provide feasible recommendations for the development of clinical pharmacy in China by identifying current problems and growth opportunities. Full development of clinical pharmacy as a mature clinical discipline will help promote the rational use of drugs by both clinicians and patients and lead to enhanced drug efficacy and safety.

  16. The current state and trends of the development of universities in Ukraine

    Directory of Open Access Journals (Sweden)

    O.B. Morhulets

    2015-09-01

    Full Text Available Education is the basis of social, political, economic, spiritual, and cultural development. Therefore, the study of the current state and trends of the development of Ukrainian universities is a significant factor of social and economic progress of the country.The paper reflects the general state of universities in Ukraine, in particular, the trends in dynamics: the number of students in terms of entry/graduation, sources of financing, education fields; the number of universities in the context of accreditation, types and forms of ownership; the number of outbound Ukrainian and inbound foreign students; quantitative and qualitative characteristics of teaching staff; spending on higher education and the cost of funding per student compared with other countries. The purpose of the study is the assessment of economic activity of higher educational establishments in Ukraine, the identification of problems and tendencies of their development in the context of national transformational processes in education and formation of the society of knowledge. The methodical base used in the study is analysis and synthesis, methods of comparison and generalization, extrapolation, index and graphical methods. The practical value of the study is based on the results of a thorough analysis of university activities. Such results reveal the current state and trends of the development of universities under conditions of higher education transformation in Ukraine and its integration into the European educational area. The results of research improve understanding of the state and problems of the universities and provide the foundations for further research in the field of the national education system development and for improving of the quality of young professionals’ training. The trends of the university development indicate that the reorganization of higher education which is being currently taken place, already results in the emergence of new competencies of

  17. Development of a high average current polarized electron source with long cathode operational lifetime

    Energy Technology Data Exchange (ETDEWEB)

    C. K. Sinclair; P. A. Adderley; B. M. Dunham; J. C. Hansknecht; P. Hartmann; M. Poelker; J. S. Price; P. M. Rutt; W. J. Schneider; M. Steigerwald

    2007-02-01

    Substantially more than half of the electromagnetic nuclear physics experiments conducted at the Continuous Electron Beam Accelerator Facility of the Thomas Jefferson National Accelerator Facility (Jefferson Laboratory) require highly polarized electron beams, often at high average current. Spin-polarized electrons are produced by photoemission from various GaAs-based semiconductor photocathodes, using circularly polarized laser light with photon energy slightly larger than the semiconductor band gap. The photocathodes are prepared by activation of the clean semiconductor surface to negative electron affinity using cesium and oxidation. Historically, in many laboratories worldwide, these photocathodes have had short operational lifetimes at high average current, and have often deteriorated fairly quickly in ultrahigh vacuum even without electron beam delivery. At Jefferson Lab, we have developed a polarized electron source in which the photocathodes degrade exceptionally slowly without electron emission, and in which ion back bombardment is the predominant mechanism limiting the operational lifetime of the cathodes during electron emission. We have reproducibly obtained cathode 1/e dark lifetimes over two years, and 1/e charge density and charge lifetimes during electron beam delivery of over 2?105???C/cm2 and 200 C, respectively. This source is able to support uninterrupted high average current polarized beam delivery to three experimental halls simultaneously for many months at a time. Many of the techniques we report here are directly applicable to the development of GaAs photoemission electron guns to deliver high average current, high brightness unpolarized beams.

  18. Development and Testing of High Current Hollow Cathodes for High Power Hall Thrusters

    Science.gov (United States)

    Kamhawi, Hani; Van Noord, Jonathan

    2012-01-01

    NASA's Office of the Chief Technologist In-Space Propulsion project is sponsoring the testing and development of high power Hall thrusters for implementation in NASA missions. As part of the project, NASA Glenn Research Center is developing and testing new high current hollow cathode assemblies that can meet and exceed the required discharge current and life-time requirements of high power Hall thrusters. This paper presents test results of three high current hollow cathode configurations. Test results indicated that two novel emitter configurations were able to attain lower peak emitter temperatures compared to state-of-the-art emitter configurations. One hollow cathode configuration attained a cathode orifice plate tip temperature of 1132 degC at a discharge current of 100 A. More specifically, test and analysis results indicated that a novel emitter configuration had minimal temperature gradient along its length. Future work will include cathode wear tests, and internal emitter temperature and plasma properties measurements along with detailed physics based modeling.

  19. Eddy Current Pulsed Thermography with Different Excitation Configurations for Metallic Material and Defect Characterization.

    Science.gov (United States)

    Tian, Gui Yun; Gao, Yunlai; Li, Kongjing; Wang, Yizhe; Gao, Bin; He, Yunze

    2016-06-08

    This paper reviews recent developments of eddy current pulsed thermography (ECPT) for material characterization and nondestructive evaluation (NDE). Due to the fact that line-coil-based ECPT, with the limitation of non-uniform heating and a restricted view, is not suitable for complex geometry structures evaluation, Helmholtz coils and ferrite-yoke-based excitation configurations of ECPT are proposed and compared. Simulations and experiments of new ECPT configurations considering the multi-physical-phenomenon of hysteresis losses, stray losses, and eddy current heating in conjunction with uniform induction magnetic field have been conducted and implemented for ferromagnetic and non-ferromagnetic materials. These configurations of ECPT for metallic material and defect characterization are discussed and compared with conventional line-coil configuration. The results indicate that the proposed ECPT excitation configurations can be applied for different shapes of samples such as turbine blade edges and rail tracks.

  20. Eddy Current Pulsed Thermography with Different Excitation Configurations for Metallic Material and Defect Characterization

    Directory of Open Access Journals (Sweden)

    Gui Yun Tian

    2016-06-01

    Full Text Available This paper reviews recent developments of eddy current pulsed thermography (ECPT for material characterization and nondestructive evaluation (NDE. Due to the fact that line-coil-based ECPT, with the limitation of non-uniform heating and a restricted view, is not suitable for complex geometry structures evaluation, Helmholtz coils and ferrite-yoke-based excitation configurations of ECPT are proposed and compared. Simulations and experiments of new ECPT configurations considering the multi-physical-phenomenon of hysteresis losses, stray losses, and eddy current heating in conjunction with uniform induction magnetic field have been conducted and implemented for ferromagnetic and non-ferromagnetic materials. These configurations of ECPT for metallic material and defect characterization are discussed and compared with conventional line-coil configuration. The results indicate that the proposed ECPT excitation configurations can be applied for different shapes of samples such as turbine blade edges and rail tracks.

  1. Computer programs for the acquisition and analysis of eddy-current array probe data

    Energy Technology Data Exchange (ETDEWEB)

    Pate, J.R.; Dodd, C.V.

    1996-07-01

    Objective of the Improved Eddy-Curent ISI (in-service inspection) for Steam Generators Tubing program is to upgrade and validate eddy-current inspections, including probes, instrumentation, and data processing techniques for ISI of new, used, and repaired steam generator tubes; to improve defect detection, classification and characterization as affected by diameter and thickness variations, denting, probe wobble, tube sheet, tube supports, copper and sludge deposits, even when defect types and other variables occur in combination; to transfer this advanced technology to NRC`s mobile NDE laboratory and staff. This report documents computer programs that were developed for acquisition of eddy-current data from specially designed 16-coil array probes. Complete code as well as instructions for use are provided.

  2. Development of fiber-optic current sensing technique and its applications in electric power systems

    Science.gov (United States)

    Kurosawa, Kiyoshi

    2014-03-01

    This paper describes the development and applications of a fiber-optic electric current sensing technique with the stable properties and compact, simple, and flexible structure of the sensing device. The special characteristics of the sensors were achieved by use of the special low birefringence fiber as the Faraday-effect sensing element and were also achieved with creation of sensing schemes which matched with the features of the fiber. Making use of the excellent features of the sensing technique, various current monitoring devices and systems were developed and applied practically for the control and maintenance in the electric power facility. In this paper, the design and performance of the sensing devices are introduced first. After that, examples of the application systems practically applied are also introduced, including fault section/point location systems for power transmission cable lines.

  3. [Service robots in elderly care. Possible application areas and current state of developments].

    Science.gov (United States)

    Graf, B; Heyer, T; Klein, B; Wallhoff, F

    2013-08-01

    The term "Service robotics" describes semi- or fully autonomous technical systems able to perform services useful to the well-being of humans. Service robots have the potential to support and disburden both persons in need of care as well as nursing care staff. In addition, they can be used in prevention and rehabilitation in order to reduce or avoid the need for help. Products currently available to support people in domestic environments are mainly cleaning or remote-controlled communication robots. Examples of current research activities are the (further) development of mobile robots as advanced communication assistants or the development of (semi) autonomous manipulation aids and multifunctional household assistants. Transport robots are commonly used in many hospitals. In nursing care facilities, the first evaluations have already been made. So-called emotional robots are now sold as products and can be used for therapeutic, occupational, or entertainment activities.

  4. Current developments of coumarin-based anti-cancer agents in medicinal chemistry.

    Science.gov (United States)

    Emami, Saeed; Dadashpour, Sakineh

    2015-09-18

    Cancer is one of the leading health hazards and the prominent cause of death in the world. A number of anticancer agents are currently in clinical practice and used for treatment of various kinds of cancers. There is no doubt that the existing arsenal of anticancer agents is insufficient due to the high incidence of side effects and multidrug resistance. In the efforts to develop suitable anticancer drugs, medicinal chemists have focused on coumarin derivatives. Coumarin is a naturally occurring compound and a versatile synthetic scaffold possessing wide spectrum of biological effects including potential anticancer activity. This review article covers the current developments of coumarin-based anticancer agents and also discusses the structure-activity relationship of the most potent compounds.

  5. Developments in near electrical resonance signal enhancement (NERSE) eddy-current methods

    Science.gov (United States)

    Hughes, Robert; Dixon, Steve

    2015-03-01

    In industry, the detection of small defects above a background noise threshold is always a limiting factor. This is true for even the most sensitivity and reliable of NDT techniques. However, defect signals in eddy-current (EC) inspections have the potential to be boosted above noise thresholds by exploiting the near electrical resonance signal enhancement (NERSE) phenomena, resulting from resonant frequency-shifting of an EC system as the coil passes over a defect. Following on from the observation and characterisation of this phenomenon, NERSE based EC methods are being investigated and developed for the detection of sub-millimeter surface defects in Aerospace superalloys. This paper discusses current advances in the development of such techniques and explores the potential of NERSE exploitation as well as examining its limitations.

  6. [Health education for major parasitic diseases in rural community of China: current status and future development].

    Science.gov (United States)

    Zhang, Jing; Lin, Dan-dan

    2013-08-01

    Owing to human parasitic diseases being related to behavior, the health education as an important measure to prevent parasite infections through human behavior intervention, has played an important role in the process of parasitic disease prevention and control in rural area of China. This paper comments on the development history of the health education for parasitic disease prevention and control, current intervention modes and the effect of the health education for parasitic diseases in rural area. This paper also summarizes the role and impact of different modes of the health education for parasitic disease prevention and control and gives some suggestions to future development of the health education in rural area under current prevalent situation of parasitic diseases.

  7. Current Situation and Developing Countermeasures of Postgraduate Innovation Center in China

    Directory of Open Access Journals (Sweden)

    Li Can

    2017-01-01

    Full Text Available Innovation is the driving force to promote the development of our nation. Postgraduate education, as an important approach to cultivate high-level talents, is a major part of the national innovation system. The establishment of the Postgraduate Innovation Center has an important significance for the cultivation of innovative talents in colleges and universities. This paper expounds the connotation and characteristics of Postgraduate Innovation Center and analyzes its current situation, operation mode, function orientation, institution settings and the innovative products. The paper also points out the problems in the current situation of the Postgraduate Innovation Center and finds the factors which restrict the development of the center. Finally, the paper puts forward some corresponding countermeasures.

  8. Under the new situation and the current situation of our English education and reform development prospects

    Institute of Scientific and Technical Information of China (English)

    Ji Ruan

    2015-01-01

    Since the reform and opening up, China has achieved a certain degree of English education development. However, with the global trend of strengthening economic integration in the new era background, English education is gradually showing some difficult problems. Therefore, strengthening English education reform has become a hot topic of concern. The author based on the status quo of China' s English education, focusing on analysis of the content of the current English education reform.

  9. Dynamics at Solid State Surfaces and Interfaces, Volume 1 Current Developments

    CERN Document Server

    Bovensiepen, Uwe; Wolf, Martin

    2010-01-01

    This two-volume work covers ultrafast structural and electronic dynamics of elementary processes at solid surfaces and interfaces, presenting the current status of photoinduced processes. Providing valuable introductory information for newcomers to this booming field of research, it investigates concepts and experiments, femtosecond and attosecond time-resolved methods, as well as frequency domain techniques. The whole is rounded off by a look at future developments.

  10. Integrated Computational Materials Engineering of Titanium: Current Capabilities Being Developed Under the Metals Affordability Initiative

    Science.gov (United States)

    Glavicic, M. G.; Venkatesh, V.

    2014-07-01

    A technical review of the titanium model development programs currently funded under the Metals Affordability Initiative is presented. Progress of the "Advanced Titanium Alloy Microstructure and Mechanical Property Modeling" and "ICME of Microtexture Evolution and its Effect on Cold Dwell/High/Low Cycle Fatigue Behavior of Dual Phase Titanium Alloys" will be reviewed followed by a discussion of the future modeling needs of the aerospace industry.

  11. The current status and trend of clinical pharmacology in developing countries

    Science.gov (United States)

    2013-01-01

    Background Several international forums for promoting clinical pharmacology in developing countries have been held since 1980, and several clinical pharmacology programmes targeting developing countries were instituted such that the status of clinical pharmacology in developing countries is not where it was 50 years ago. Therefore, a survey and an appraisal of the literature on the current status of clinical pharmacology in developing countries were undertaken with a hope that it would enable development of appropriate strategies for further promotion of clinical pharmacology in these countries. Methods First, nine determinants (or enabling factors) for running a successful clinical pharmacology programme were identified, i.e., disease burden, drug situation, economic growth, clinical pharmacology activities, recognition, human capital, government support, international collaboration, and support for traditional/alternative medicines. These factors were then evaluated with regard to their current status in the developing countries that responded to an electronic questionnaire, and their historical perspective, using the literature appraisal. From these, a projected trend was constructed with recommendations on the way forward. Results Clinical pharmacology services, research and teaching in developing countries have improved over the past 50 years with over 90% of countries having the appropriate policies for regulation and rational use of medicines in place. Unfortunately, policy implementation remains a challenge, owing to a worsening disease burden and drug situation, versus fewer clinical pharmacologists and other competing priorities for the national budgets. This has led to a preference for training ‘a physician clinical pharmacologist’ in programmes emphasizing local relevancy and for a shorter time, and the training of other professionals in therapeutics for endemic diseases (task shifting), as the most promising strategies of ensuring rational use of

  12. The current situation of impact of coal mine developing on environment in China and government proposal

    Energy Technology Data Exchange (ETDEWEB)

    Lu Yang [China University of Mining and Technology, Beijing (China). Ministry of Land and Resources

    2005-07-01

    Current environmental problems caused by coal mining in China, the importance of management of the environment, impact of coal mining on land and water resources, and upcoming coal development are discussed. It is suggested that the government should act in two ways: take responsibility for management of reclamation of mines existing before 1986, and set up mechanisms to protect the environment, starting with the publishing of relevant laws and regulations. Methods for solving environmental issues include: prepare a practical plan, establish an environmental control fund, establish a special fund to protect the environment, and develop new ways to combine protection of the biological environment and land reclamation. 5 refs., 3 tabs.

  13. Current Status and Future Development of Integrated Geophysical Technology in China

    Institute of Scientific and Technical Information of China (English)

    HeZhanxiang

    2003-01-01

    The gap between China''s integrated geophysical technology and the world''s advanced technologies has been significantly narrowed as the result of developments in the last decade.The new technology has played a very important role in oil and gas exploration in China, especially for the purposes of targeting seismically opaque zones, decreasing exploration risk, and improving exploration efficiency in the western territories and complex areas in China. The current status and future development of non-seismic integrated geophysical teams in China is discussed.

  14. CURRENT STATE AND DEVELOPMENT OF THE FISHERIES SECTOR OF UKRAINE IN THE CRISIS

    Directory of Open Access Journals (Sweden)

    І. Hrytsyniak

    2015-03-01

    Full Text Available Purpose. Fisheries has a strategic importance for supplying the population with food, while the sectors of the national economy with raw materials, for strengthening the country’s position in the international arena, for preserving spatial and national integrity of Ukraine, plays an important role in the restoration of natural resources and in the increase in employment. In recent years, fisheries sector of Ukraine is in a severe, protracted economic crisis. Considering its socio-economic and strategic importance for the state, there is a task for developing an effective policy for fisheries development in Ukraine that defines the relevance of the research and practical importance of its results. Thus, a compilation and analysis of the existing information on the current state and development of fisheries sector in the crisis period will allow a deeper understanding of problems in the fisheries sector in Ukraine and finding quick solutions. The main goal of the state policy in the field of fisheries in Ukraine has to be meeting the needs of the population in fish and fish products by creating conditions for effective operations and development of aquaculture and fishing enterprises. Findings. The article reviews the current state of the development of fisheries sector in Ukraine, consumption, catch, processing of fish and seafood, dynamics of fish product exports and imports, legislative and regulatory framework of fisheries sector, state of the implementation of WTO and EU requirements, as well as finding ways for the fisheries sector out from the crisis. Originality. This work is a compilation of the information on the current state of fisheries sector development in Ukraine. The information is provided in the form of a coherent presentation of information on the current state of fisheries sector in Ukraine, both in the domestic and foreign markets. Practical Value. The fact that the fisheries sector of Ukraine is still in a depressive state

  15. Current Research and Classroom Practice: Toward More Inclusive Approaches to Literacy Development in Schools

    Directory of Open Access Journals (Sweden)

    David Booth

    2009-07-01

    Full Text Available This paper offers an exploration of current research and related practice in boys’ literacy development, interprets key findings in the literature, and further explores some of the complex dilemmas and debates related to the ‘gender gap’ – i.e., differences between the achievement of boys and girls in this area. In conclusion, the authors suggest that governments, policy-makers, administrators, teachers and parents all need to closely examine and consider available research-based strategies and classroom interventions that can effectively support both boys and girls in their literacy development

  16. Current Situations of Agricultural Sci-tech Innovation and Development Path in Nantong

    Institute of Scientific and Technical Information of China (English)

    YUAN Chun-xin; SUN Qing-shan; QIU Hai-rong; ZHU Hai-yan; TANG Ming-xia; XUE Chen-xia

    2012-01-01

    Nantong is a typical region of large population and little land.The conflict between resources and environment is growing.Thus,the improvement of independent innovation ability based on current situations,oriented towards the future and relying on scientific and technological force directly decides the effect of strong economic city construction.Through analysis on achievements of agricultural sci-tech innovation works,existing problems and demand for developing modern agriculture in Nantong,we present development ideas,target orientation and basic principles of agricultural sci-tech innovation works in Nantong,and put forward eight paths.

  17. Polarizable Embedding Based on Multiconfigurational Methods: Current Developments and the Road Ahead

    DEFF Research Database (Denmark)

    Hedegård, Erik D.; Jensen, H. J. A.; Kongsted, J.

    2014-01-01

    This perspective gives a brief overview of recent developments within the polarizable embedding (PE) method - a multiscale approach developed over the last years. In particular, we are concerned with a recent coupling of the PE method to a multiconfiguration self-consistent field (MCSCF) code....... Current applications and target systems are outlined, and methods to incorporate dynamical correlation are discussed. With respect to dynamical correlation, the focus is on perturbative treatments as well as a range-separated multiconfigurational hybrid between MCSCF and density functional theory (MC...

  18. International development assistance for renewable technologies: current programs and institutional requirements

    Energy Technology Data Exchange (ETDEWEB)

    Ashworth, J. H.; Meunier, R. E.

    1979-05-01

    Within the last several years, foreign-assistance donor agencies have begun to provide significant aid for the search for renewable energy sources for developing nations. This paper reports preliminary results from a survey of development--assistance projects in renewable energy sources, indicating which areas are extensions of traditional assistance areas and which are new areas of involvement. The last two portions of the paper indicate certain shortcomings in the current effort, and linkages that must be emphasized in order to incease the effectiveness of the range of donor activities.

  19. Current Developments in Electrophoretic and Chromatographic Separation Methods on Microfabricated Devices

    DEFF Research Database (Denmark)

    Kutter, Jörg Peter

    2000-01-01

    a brief overview of current developments in electrophoretic and chromatographic separation methods on microfabricated devices, and highlight some of the trends emerging from recent research results (published or pre-published before November 1999). (C)2000 Published by Elsevier Science B.V, All rights......Microchip-based separation techniques are essential elements in the development of fully integrated micro-total analysis systems, which are envisioned to become powerful instruments for obtaining and assessing analytical data in research, industry, and everyday life. This article's goal is to give...

  20. Preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals: strategy, challenges, current practices.

    Science.gov (United States)

    Morford, LaRonda L; Bowman, Christopher J; Blanset, Diann L; Bøgh, Ingrid B; Chellman, Gary J; Halpern, Wendy G; Weinbauer, Gerhard F; Coogan, Timothy P

    2011-08-01

    Evaluation of pharmaceutical agents in children is now conducted earlier in the drug development process. An important consideration for this pediatric use is how to assess and support its safety. This article is a collaborative effort of industry toxicologists to review strategies, challenges, and current practice regarding preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals. Biopharmaceuticals include a diverse group of molecular, cell-based or gene therapeutics derived from biological sources or complex biotechnological processes. The principles of preclinical support of pediatric drug development for biopharmaceuticals are similar to those for small molecule pharmaceuticals and in general follow the same regulatory guidances outlined by the Food and Drug Administration and European Medicines Agency. However, many biopharmaceuticals are also inherently different, with limited species specificity or immunogenic potential which may impact the approach taken. This article discusses several key areas to aid in the support of pediatric clinical use, study design considerations for juvenile toxicity studies when they are needed, and current practices to support pediatric drug development based on surveys specifically targeting biopharmaceutical development. © 2011 Wiley-Liss, Inc.

  1. Technology Commercialisation in a Developing Country: Current Condition and Its Challenge in Indonesia

    Directory of Open Access Journals (Sweden)

    Wawan Dhewanto

    2012-01-01

    Full Text Available Innovation is considered the main engine of economic growth in both developed and developing countries. Despite the important role of innovation, little has been understood about technology transfer becoming a commercial success in developing countries, especially in the Indonesian context. The purpose of this paper is to identify technology commercialisation activities in Indonesia. Based on secondary data sources, an analysis of the current state regarding the issue is constructed. The findings in this paper suggest that technology commercialisation in Indonesia is initiated at the levels of university, government research institution, and corporate. This study provides insights for policy makers, business leaders, and university administrators into the appropriate roles of institutions and organisations in promoting and assisting technology commercialisation activities of their respective inventors.Key words: Technology commercialisation, developing country, university, government research institution, corporate

  2. Space Robotics: Current Status, Long-term Objectives, and Development Trends. Analytical Review

    Directory of Open Access Journals (Sweden)

    P. P. Belonozhko

    2016-01-01

    Full Text Available Prospects for space robotics concern both the development of used prototypes to extend the capabilities and the creation of new classes of systems, the operating analogues of which are, currently, unavailable. Thus, a uniqueness of the objects of space robotics, extreme operating conditions, difficulty in full-scale ground work and tests define a variety of design solutions and a wide scope of issues for further theoretical and experimental studies. The paper highlights the tasks successfully solved up to date, involving the space robotics equipment that was used in orbital environment, those of currently solved, involving the robotics equipment that is in use, and the long-term objectives, following from the logic of the space technology development to define the ways of its further development and require a development and creation of new equipment of space robotics. Thus, the development trends of space robotics are largely defined by its history of development, on the one hand, and by a growing demand for the robotic service as applied to the promising objects of space technology, on the other one. The paper considers the trends of space robotics development, which are a consequence of the natural logic of its development and are determined by a demand for advanced objects of space technology in robotic servicing. Highlights the most important elements of a design concept and the creating and operating features of the multipurpose extendable space systems, including those, which have no analogues and prototypes, are rolled into one demand for automation, and associated with their creation, operation, and problems of utilization. The concept of assembly and service autonomous robotic space modules has been under consideration. Within the orbital assembly procedure, the typical dynamic modes, relevant in terms of practical implementation of controlled movement are highlighted.

  3. Comparison of Ca2+ currents of peptidergic neurons developing differing morphology with time in culture.

    Science.gov (United States)

    Meyers, D E; Cooke, I M

    1997-02-01

    The whole-cell patch-clamp technique was used to examine Ca2+ currents (ICa) in mature neurons cultured in defined medium and derived from the principal neurosecretory system of decapod crustaceans, the X-organ-sinus gland. After 1 day in culture, X-organ neurons of the crab Cardisoma carnifex showed vigorous outgrowth characterized either by the production of broad lamellipodia (veils) or, from smaller somata, a branching morphology. The neurons developing veils (veilers) had a large ICa (approximately 650 pA) and ICa current density (approximately 5 microA cm-2) while other types of neuron had little or no ICa. This distinction between the two types was still present after 5-6 days in culture. However, morphologies observed after additional outgrowth, when correlated with the ICa responses, allowed four groups to be distinguished: (1) veilers and (2) branching veilers, which developed from veilers and had a similar ICa density (approximately 3 microA cm-2); and, developing from the 1 day branchers, (3) spiny branchers or (4) small cells (ICa density approximately 0.8 microA cm-2). Immunoreactivity indicative of the presence of crustacean hyperglycemic hormone was found in all veilers and branching veilers tested, while moltinhibiting hormone reactivity, when observed, was seen in cells having a robust ICa density (> or = 1.2 microA cm-2). Normalized average current-voltage curves for each morphological group were examined for changes with increasing time in culture. The curves were consistent with the ICa being produced by a population of high-voltage-activated Ca2+ channels whose properties are biophysically indistinguishable and unaffected by time in culture. The averaged peak current did not change, despite an increase in neuronal surface area as outgrowth proceeded, and this resulted in a reduction of ICa density. This indicated that net addition of Ca2+ channels did not match the addition of new membrane under our culturing conditions.

  4. Potential chemotherapeutic targets for Japanese encephalitis: current status of antiviral drug development and future challenges.

    Science.gov (United States)

    Ishikawa, Tomohiro; Konishi, Eiji

    2015-01-01

    Japanese encephalitis (JE) remains a public health threat in Asia. Although several vaccines have been licensed, ∼ 67,900 cases of the disease are estimated to occur annually, probably because the vaccine coverage is low. Therefore, effective antiviral drugs are required to control JE. However, no licensed anti-JE drugs are available, despite extensive efforts to develop them. We provide a general overview of JE and JE virus, including its transmission cycle, distribution, structure, replication machinery, immune evasion mechanisms and vaccines. The current situation in antiviral drug development is then reviewed and future perspectives are discussed. Although the development of effective anti-JE drugs is an urgent issue, only supportive care is currently available. Recent progress in our understanding of the viral replication machinery and immune evasion strategies has identified new targets for anti-JE drug development. To date, most candidate drugs have only been evaluated in single-drug formulations, and efficient drug delivery to the CNS has virtually not been considered. However, an effective anti-JE treatment is expected to be achieved with multiple-drug formulations and a targeted drug delivery system in the near future.

  5. Current progress in the development of therapeutic vaccines for chronic hepatitis B virus infection

    Directory of Open Access Journals (Sweden)

    Faezeh Ghasemi

    2016-07-01

    Full Text Available Chronic hepatitis B is still a major public health issue despite the successful prophylactic vaccination attempts. Chronicity of hepatitis B virus(HBV is mainly due to its ability to debilitate host's immune system. Therefore, major measures have been taken to stop this process and help patients with chronic hepatitis B infection recover from their illness. While satisfactory results have been achieved using preventive HBV vaccines, a reliable and effective therapeutic treatment is still in need of extensive studies. Current treatments for chronic hepatitis B include direct antiviral agents and nucleoside/nucleotide analogs, which are not always effective and are also costly. In addition, due to the fact that chronic HBV is responsible for debilitation of the immune system, studies have focused on developing therapeutic vaccines to help host's immune system recover and limit the infection. Several approaches including but not restricted to recombinant peptide-based, DNA-based, viral vector-based, and cell-based approaches are currently in use to develop therapeutic vaccines against the chronic form of HBV infection. In the current review, the authors will first discuss the role of the immune system in chronic hepatitis B infection and will then focus on latest advancements in therapeutic vaccination of HBV especially the clinical trials that have been carried out so far.

  6. Current transport and microstructural development in BSCCO tapes and joints fabricated by groove rolling

    Science.gov (United States)

    Iyer, A. N.; Lu, W.; Mironova, M.; Vipulanandan, C.; Balachandran, U.; Salama, K.

    2000-02-01

    The powder-in-tube technique, which includes wire drawing and rolling, has been widely used to fabricate superconducting tapes for possible electric power applications. In the present study the starting billet was reduced in size by groove rolling instead of by wire drawing. To optimize the deformation and thermomechanical treatment processes, BSCCO wires of various dimensions were fabricated. The wires were flat rolled to a final thickness of 250 µm. Short-length tapes were subjected to a series of thermal and deformation steps. Phase development and microstructural development during the process were monitored by XRD, SEM and TEM. Current transport properties of the tapes were determined in the temperature range of 20-77 K in self-field. Thermomechanical treatment resulted in tapes with average critical current densities of 18 000 A cm-2 at 77 K. High-resolution electron microscopy revealed better texturing and grain structure at the superconductor-silver interface. Superconducting lap- and butt-joints have been formed by a chemical etching technique. Detailed microstructural and current transport properties of the joints have also been measured.

  7. Development of an unstructured-grid wave-current coupled model and its application

    Science.gov (United States)

    Feng, Xingru; Yin, Baoshu; Yang, Dezhou

    2016-08-01

    An unstructured grid wave-current coupled model was developed by coupling the SWAN (Simulating Waves Nearshore) wave model and ADCIRC (Advanced Circulation model) ocean model through the Model Coupling Toolkit (MCT). The developed coupled model has high spatial resolution in the coastal area and is efficient for computation. The efficiency of the newly developed SWAN + ADCIRC model was compared with that of the widely-used SWAN + ADCIRC coupled model, in which SWAN and ADCIRC are coupled directly rather than through the MCT. Results show that the directly-coupled model is more efficient when the total number of computational cores is small, but the MCT-coupled model begin to run faster than the directly-coupled model when more computational cores are used. The MCT-coupled model maintains the scalability longer and can increase the simulation efficiency more than 35% by comparing the minimum wall clock time of one day simulation in the test runs. The MCT-coupled SWAN + ADCIRC model was used to simulate the storm surge and waves during the typhoon Usagi which formed in the western Pacific on September 17, 2013 and landed at Shanwei, China. Three numerical experiments were performed to investigate the effect of wave-current interaction on the storm surge and waves. The results show that the coupled model can better simulate the storm surge and waves when considering the wave-induced radiation stress, the wave effect on the wind stress drag coefficient and the modulation of current and water level on waves. During the typhoon Usagi, the effect of wave radiation stress could result in a maximum of 0.75 m increase in the extreme storm surge, and the wave induced wind stress could cause a -0.82∼0.48 m change of the extreme storm surge near the coastal area. Besides, the radiation stress forced currents cannot be ignored either in the study of mass transport at coastal zones. Results of this study are useful for understanding the wave-current interaction processes and

  8. The current status of the development of renewable energy sources worldwide and in Russia

    Science.gov (United States)

    Fortov, V. E.; Popel', O. S.

    2014-06-01

    Resorting to renewable energy sources (RESs) as one of the bases of the promising world energy industry has become a logical result of the historical development and the recognition that is necessary to diversify primary energy sources being used, with the aim of enhancing both energy and ecological security of countries, regions, and concrete energy consumers. The review of the development of new technologies used for conversion of RESs, the progress of which can be characterized by the fact that by the year 2013 the total generating capacity of RES-based power plants now in operation has amounted to 500 GW—by a factor of 1.5 more than the total generating capacity of all nuclear power stations in the world. The paper presents an analysis of the current status of RESs and problems that restrain their development in Russia. It is noted that the peculiarities of the energy situation in Russia impose the specific requirements upon drawing up the programs of the development of RESs. Along with the use of RESs as part of systems of centralized energy supply, which is a priority for most industrially developed countries and promises the most large-scale introduction of RESs in Russia, it is necessary, first of all, to give attention to the development and creation of systems for independent supply of consumers with power and heat and the development of distributed powergenerating systems using RESs.

  9. Bone cements for percutaneous vertebroplasty and balloon kyphoplasty: Current status and future developments

    Directory of Open Access Journals (Sweden)

    Zhiwei He

    2015-01-01

    Full Text Available Osteoporotic vertebral compression fractures (OVCFs have gradually evolved into a serious health care problem globally. In order to reduce the morbidity of OVCF patients and improve their life quality, two minimally invasive surgery procedures, vertebroplasty (VP and balloon kyphoplasty (BKP, have been developed. Both VP and BKP require the injection of bone cement into the vertebrae of patients to stabilize fractured vertebra. As such, bone cement as the filling material plays an essential role in the effectiveness of these treatments. In this review article, we summarize the bone cements that are currently available in the market and those still under development. Two major categories of bone cements, nondegradable acrylic bone cements (ABCs and degradable calcium phosphate cements (CPCs, are introduced in detail. We also provide our perspectives on the future development of bone cements for VP and BKP.

  10. Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry.

    Science.gov (United States)

    Keri, Rangappa S; Hiremathad, Asha; Budagumpi, Srinivasa; Nagaraja, Bhari Mallanna

    2015-07-01

    The properties of benzimidazole and its derivatives have been studied over more than one hundred years. Benzimidazole derivatives are useful intermediates/subunits for the development of molecules of pharmaceutical or biological interest. Substituted benzimidazole derivatives have found applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to name just a few. This work systematically gives a comprehensive review in current developments of benzimidazole-based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic agents, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial agents, and other medicinal agents. This review will further be helpful for the researcher on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimidazole drugs/compounds.

  11. The NRC's SPAR Models: Current Status, Future Development, and Modeling Issues

    Energy Technology Data Exchange (ETDEWEB)

    Robert F. Buell

    2008-09-01

    Probabilistic risk assessments (PRAs) play an increasingly important role in the regulatory framework of the U.S. nuclear power industry. The Nuclear Regulatory Commission (NRC) relies on a set of plant-specific Standardized Plant Analysis Risk (SPAR) models to provide critical risk-based input to the regulatory process. The Significance Determination Process (SDP), Management Directive 8.3 - NRC Incident Investigation Program, Accident Sequence Precursor (ASP) and Mitigating Systems Performance Index (MSPI) programs are among the regulatory initiatives that receive significant input from the SPAR models. Other uses of the SPAR models include: Screening & Resolution of Generic Safety Issues, License Amendment reviews and Notice of Enforcement Discretion (NOEDs). This paper presents the current status of SPAR model development activities, future development objectives, and issues related to the development, verification and maintenance of the SPAR models.

  12. Ukrainian Virtual Observatory: Current Status and Perspectives of Development of Joint Archives of Observations

    Science.gov (United States)

    Vavilova, I. B.; Pakuliak, L. K.; Protsyuk, Yu. I.; Virun, N. V.; Kashuba, S. G.; Pikhun, A. I.; Andrievsky, S. M.; Mazhaev, A. E.; Kazantseva, L. V.; Shlyapnikov, A. A.; Shulga, A. V.; Zolotukhina, A. V.; Sergeeva, T. P.; Miroshnichenko, A. P.; Andronov, I. L.; Breus, V. V; Virnina, N. A.

    2011-07-01

    The current state of the observational data archives of seven observatories of Ukraine which were created from 1898 to 2010 is considered in respect to their suitability for including into the Ukrainian Virtual Observatory (UkrVO) database. In accordance with a current UkrVO conception approved by the Ukrainian Astronomical Association, the database of astro negatives is the main scientific component of the UkrVO. The database will include all the photo plates accumulated in Ukraine and combine them into the Joint Digitized Archive (JDA). This will provide for a user an easy access to textual data and images using web interface and a corresponding search engine. The data archives obtained from CCD and radio observations in Ukraine are also discussed as scientific components of the UkrVO. Some prospects of the JDA development are formulated.

  13. Current industrial practice of managing risks in product development project portfolios

    DEFF Research Database (Denmark)

    Weng, R.; Oehmen, Josef; Ben-Daya, M.

    2013-01-01

    Managing portfolios of development and engineering projects currently presents significant challenges to companies. This is even more the case in the management of portfolio risks, where both industry and academia currently lack a clear conceptual understanding of what portfolio risks are and what...... influences them. The objective of this paper is two-fold: First, based on a literature review and industry focus group discussions, we introduce a new model for describing portfolio-level risks. It consists of three types of risks (escalated risks, common cause risks, and cascading risks) based on 9 types...... of interdependencies in PD project portfolios (Technology, Budget, Objectives and Requirements, Infrastructure and Equipment, Skillset and Human Resources, Process and Schedule, Supplier, Legal and Regulatory, and finally Market and Customer). Second, we investigate how risk management on the portfolio level...

  14. Current Status on the Development of a Double Wall Tube Steam Generator

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Ho Yun; Choi, Byoung Hae; Kim, Jong Man; Kim, Byung Ho

    2007-12-15

    A fast reactor, which uses sodium as a coolant, has a lot of merits as a next generation nuclear reactor. However, the possibility of a sodium-water reaction occurrence hinders the commercialization of this reactor. As one way to improve the reliability of a steam generator, a double-wall tube steam generator is being developed in GEN-4 program. In this report, the current state of the technical developments for a double-wall tube steam generator are reviewed and a future plan for the development of a double-wall tube steam generator is established. The current focuses of this research are an improvement of the heat transfer capability for a double-wall tube and the development of a proper leak detection method for the failure of a double-wall tube during a reactor operation. The ideal goal is an on-line leak detection of a double wall tube to prevent the sodium-water reaction. However, such a method is not developed as yet. An alternative method is being used to improve the reliability of a steam generator by performing a non-destructive test of a double wall tube during the refueling period of a reactor. In this method a straight double wall tube is employed to perform this test easily, but has a difficulty regarding an absorption of a thermal expansion of the used materials. If an on-line leak detection method is developed, the demerits of a straight double-wall tube are avoided by using a helical type double-wall tube, and the probability of a sodium-water reaction can be reduced to a level less than the design-based accident.

  15. Development of a high average current polarized electron source with long cathode operational lifetime

    Directory of Open Access Journals (Sweden)

    C. K. Sinclair

    2007-02-01

    Full Text Available Substantially more than half of the electromagnetic nuclear physics experiments conducted at the Continuous Electron Beam Accelerator Facility of the Thomas Jefferson National Accelerator Facility (Jefferson Laboratory require highly polarized electron beams, often at high average current. Spin-polarized electrons are produced by photoemission from various GaAs-based semiconductor photocathodes, using circularly polarized laser light with photon energy slightly larger than the semiconductor band gap. The photocathodes are prepared by activation of the clean semiconductor surface to negative electron affinity using cesium and oxidation. Historically, in many laboratories worldwide, these photocathodes have had short operational lifetimes at high average current, and have often deteriorated fairly quickly in ultrahigh vacuum even without electron beam delivery. At Jefferson Lab, we have developed a polarized electron source in which the photocathodes degrade exceptionally slowly without electron emission, and in which ion back bombardment is the predominant mechanism limiting the operational lifetime of the cathodes during electron emission. We have reproducibly obtained cathode 1/e dark lifetimes over two years, and 1/e charge density and charge lifetimes during electron beam delivery of over 2×10^{5}   C/cm^{2} and 200 C, respectively. This source is able to support uninterrupted high average current polarized beam delivery to three experimental halls simultaneously for many months at a time. Many of the techniques we report here are directly applicable to the development of GaAs photoemission electron guns to deliver high average current, high brightness unpolarized beams.

  16. 17 beta-estradiol modulates GABAergic synaptic transmission and tonic currents during development in vitro.

    Science.gov (United States)

    Pytel, Maria; Wójtowicz, Tomasz; Mercik, Katarzyna; Sarto-Jackson, Isabella; Sieghart, Werner; Ikonomidou, Chrysanthy; Mozrzymas, Jerzy W

    2007-05-01

    Estrogens exert a variety of modulatory effects on the structure and function of the nervous system. In particular, 17 beta-estradiol was found to affect GABAergic inhibition in adult animals but its action on GABAergic currents during development has not been elucidated. In the present study, we investigated the effect of 17 beta-estradiol on hippocampal neurons developing in vitro. In this model, mIPSC kinetics showed acceleration with age along with increased alpha1 subunit expression, similarly as in vivo. Long-term treatment with 17 beta-estradiol increased mIPSC amplitudes in neurons cultured for 6-8 and 9-11DIV and prolonged the mIPSC decaying phase only in the 9-11DIV group. The time needed for the onset of 17 beta-estradiol effect on mIPSC amplitude was approximately 48 h. In the period of 9-11DIV, treatment with 17 beta-estradiol strongly reduced the tonic conductance activated by low GABA concentrations. The effects of 17 beta-estradiol on mIPSCs and tonic conductance were not correlated with any change in expression of considered GABAAR subunits (alpha1-3, alpha5-6, gamma2) while alpha4 and delta subunits were at the detection limit. In conclusion, we provide evidence that 17 beta-estradiol differentially affects the phasic and tonic components of GABAergic currents in neurons developing in vitro.

  17. Modified Vaccinia Virus Ankara: History, Value in Basic Research, and Current Perspectives for Vaccine Development.

    Science.gov (United States)

    Volz, A; Sutter, G

    2017-01-01

    Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation vaccine against smallpox and serves as a potent vector system for development of new candidate vaccines against infectious diseases and cancer. Historically, MVA was developed by serial tissue culture passage in primary chicken cells of vaccinia virus strain Ankara, and clinically used to avoid the undesirable side effects of conventional smallpox vaccination. Adapted to growth in avian cells MVA lost the ability to replicate in mammalian hosts and lacks many of the genes orthopoxviruses use to conquer their host (cell) environment. As a biologically well-characterized mutant virus, MVA facilitates fundamental research to elucidate the functions of poxvirus host-interaction factors. As extremely safe viral vectors MVA vaccines have been found immunogenic and protective in various preclinical infection models. Multiple recombinant MVA currently undergo clinical testing for vaccination against human immunodeficiency viruses, Mycobacterium tuberculosis or Plasmodium falciparum. The versatility of the MVA vector vaccine platform is readily demonstrated by the swift development of experimental vaccines for immunization against emerging infections such as the Middle East Respiratory Syndrome. Recent advances include promising results from the clinical testing of recombinant MVA-producing antigens of highly pathogenic avian influenza virus H5N1 or Ebola virus. This review summarizes our current knowledge about MVA as a unique strain of vaccinia virus, and discusses the prospects of exploiting this virus as research tool in poxvirus biology or as safe viral vector vaccine to challenge existing and future bottlenecks in vaccinology.

  18. Dissolving current gaps in entrepreneurship education and its impact on business development in Slovakia

    Directory of Open Access Journals (Sweden)

    Helena Majdúchová

    2015-10-01

    Full Text Available This paper presents partial outcomes of the research conducted under the cover of the project “V4 Scientific Centers for the Enhancement of Financial Literacy and Entrepreneurship Education“, International Visegrad Fund, Standard Grant No. 21410134. In this paper we focus on dissolving current gaps in entrepreneurship education and its impact on business development in Slovakia (one of participating countries. We do so by using the whole variety of research methods, including structured survey, direct observation, decomposition, implication, etc. We are dealing with the identification of the university education attributes important for the entrepreneurial competences development, followed by further insights into the specific area - university support of individual initiative and entrepreneurial thinking. To avoid the subjective dimension of research outcome, we look at it from two different points of view – students and teachers perceptions. We also use a cross-cultural approach and different cultural dimensions to identify the general perception of normal state of this attribute in the society. The last part of this paper summarizes our recommendations intending to improve the current state of university education system in the field of entrepreneurial competences development.

  19. Current practice in software development for computational neuroscience and how to improve it.

    Science.gov (United States)

    Gewaltig, Marc-Oliver; Cannon, Robert

    2014-01-01

    Almost all research work in computational neuroscience involves software. As researchers try to understand ever more complex systems, there is a continual need for software with new capabilities. Because of the wide range of questions being investigated, new software is often developed rapidly by individuals or small groups. In these cases, it can be hard to demonstrate that the software gives the right results. Software developers are often open about the code they produce and willing to share it, but there is little appreciation among potential users of the great diversity of software development practices and end results, and how this affects the suitability of software tools for use in research projects. To help clarify these issues, we have reviewed a range of software tools and asked how the culture and practice of software development affects their validity and trustworthiness. We identified four key questions that can be used to categorize software projects and correlate them with the type of product that results. The first question addresses what is being produced. The other three concern why, how, and by whom the work is done. The answers to these questions show strong correlations with the nature of the software being produced, and its suitability for particular purposes. Based on our findings, we suggest ways in which current software development practice in computational neuroscience can be improved and propose checklists to help developers, reviewers, and scientists to assess the quality of software and whether particular pieces of software are ready for use in research.

  20. Current practice in software development for computational neuroscience and how to improve it.

    Directory of Open Access Journals (Sweden)

    Marc-Oliver Gewaltig

    2014-01-01

    Full Text Available Almost all research work in computational neuroscience involves software. As researchers try to understand ever more complex systems, there is a continual need for software with new capabilities. Because of the wide range of questions being investigated, new software is often developed rapidly by individuals or small groups. In these cases, it can be hard to demonstrate that the software gives the right results. Software developers are often open about the code they produce and willing to share it, but there is little appreciation among potential users of the great diversity of software development practices and end results, and how this affects the suitability of software tools for use in research projects. To help clarify these issues, we have reviewed a range of software tools and asked how the culture and practice of software development affects their validity and trustworthiness. We identified four key questions that can be used to categorize software projects and correlate them with the type of product that results. The first question addresses what is being produced. The other three concern why, how, and by whom the work is done. The answers to these questions show strong correlations with the nature of the software being produced, and its suitability for particular purposes. Based on our findings, we suggest ways in which current software development practice in computational neuroscience can be improved and propose checklists to help developers, reviewers, and scientists to assess the quality of software and whether particular pieces of software are ready for use in research.

  1. Siserände suundumused 20. sajandil = Trends of internal migration during the 20th century and at the beginning of the 21st century / Alis Tammur

    Index Scriptorium Estoniae

    Tammur, Alis

    2008-01-01

    Siserände suundadest Eestis alates 1920ndatest aastatest kuni 2007. aastani. Kaart: Linnadesse tulnud endise alalise elukoha järgi, 1922-1934. Graafik: Siserände vanusjaotus. Tabel: Linnade ja maa-asulate vahelised rändesuunad 2000-2007

  2. Siserände suundumused 20. sajandil = Trends of internal migration during the 20th century and at the beginning of the 21st century / Alis Tammur

    Index Scriptorium Estoniae

    Tammur, Alis

    2008-01-01

    Siserände suundadest Eestis alates 1920ndatest aastatest kuni 2007. aastani. Kaart: Linnadesse tulnud endise alalise elukoha järgi, 1922-1934. Graafik: Siserände vanusjaotus. Tabel: Linnade ja maa-asulate vahelised rändesuunad 2000-2007

  3. Thermal NDE of thick GRP panels by means of a Pulse Modulated Lock-In Thermography technique

    Directory of Open Access Journals (Sweden)

    Pitarresi G.

    2010-06-01

    Full Text Available This work describes the development and implementation of an infrared thermal NDE procedure for the evaluation of subsurface defects. The approach is called Pulse-Modulated Lock-In Thermography (PMLT and is based on the analysis of the frequency response of the measured temperature and comparison with the carrier frequencies launched by the external heat delivering source. The heat deposited on the object is in particular modulated as a train of square waves. This is easily achieved by periodically shuttering the heat source. The temperature is then sampled throughout the deposition of a few square waves. A lock-in algorithm is then implemented able to selectively filter out components at the main carrier frequencies of the heating signal and evaluate the phase information. Defected areas at different depths can be marked based on phase contrast, by using data from a single experiment as in Pulsed-Phase Thermography. An artificially defected thick GRP panel typical of naval monolithic hull structures, is investigated to validate the proposed technique. Experimental data have confirmed the potentials of PMLT as a flexible IR NDT approach, and its ability to be implemented by means of low cost heating and IR equipments.

  4. Passive transdermal systems whitepaper incorporating current chemistry, manufacturing and controls (CMC) development principles.

    Science.gov (United States)

    Van Buskirk, Glenn A; Arsulowicz, Daniel; Basu, Prabir; Block, Lawrence; Cai, Bing; Cleary, Gary W; Ghosh, Tapash; González, Mario A; Kanios, David; Marques, Margareth; Noonan, Patrick K; Ocheltree, Terrance; Schwarz, Peter; Shah, Vinod; Spencer, Thomas S; Tavares, Lino; Ulman, Katherine; Uppoor, Rajendra; Yeoh, Thean

    2012-03-01

    In this whitepaper, the Manufacturing Technical Committee (MTC) of the Product Quality Research Institute has updated the 1997 Transdermal Drug Delivery Systems Scale-Up and Post Approval Change workshop report findings to add important new product development and control principles. Important topics reviewed include ICH harmonization, quality by design, process analytical technologies, product and process validation, improvements to control of critical excipients, and discussion of Food and Drug Administration's Guidance on Residual Drug in Transdermal and Related Drug Delivery Systems as well as current thinking and trends on in vitro-in vivo correlation considerations for transdermal systems.

  5. [The development and current status of high-fidelity patient simulation teaching].

    Science.gov (United States)

    Chen, Shiah-Lian; Lee, Mei-Li; Liao, I-Chen; Liang, Tienli

    2013-04-01

    High-fidelity patient simulation teaching represents one of the most important innovations in healthcare education in the past two decades. In Taiwan, many medical centers and medical colleges now have clinical skill centers equipped with a high-fidelity patient simulator. Practicing clinical scenarios in this simulated environment can help strengthen students' professional essentials and competencies outside of classroom and clinical teaching settings. High-fidelity simulation teaching is an integrated teaching strategy that is continuing to receive greater attention. This article describes the historical development of high-fidelity patient simulation teaching, its current status, and applications in nursing education as a reference for nursing educators.

  6. Theranostic liposomes for cancer diagnosis and treatment: current development and pre-clinical success.

    Science.gov (United States)

    Muthu, Madaswamy S; Feng, Si-Shen

    2013-02-01

    Liposomes are one of the effective drug delivery systems that are developed based on the nanotechnology concept. Liposomal formulation is the first nanomedicine approved by the US FDA for clinical application. Recently, the marketed liposomes and stealth liposomes have made impact for cancer therapy. In addition, a few receptor-targeted liposome products have been in different phases of clinical trials, which are yet to be marketed. In the present editorial, the advantages of vitamin E TPGS-coated liposomes over the currently available PEG-coated liposomes will be described and their great potentials for nanotheranostics for cancer imaging and therapy will be covered.

  7. The age of alternative energies: the current status of new energy technology development

    Energy Technology Data Exchange (ETDEWEB)

    Kawaguchi, Y.

    1986-01-01

    This paper outlines Japan's Sunshine Project and presents the current status of the principal research and development programs involved. These are as follows: 1) solar energy (solar photovoltaic power generation, solar energy systems for industrial use); 2) geothermal energy (technology for geothermal exploration and excavation, hydrothermal power generation, discovery of high-temperature rock); 3) coal energy (coal liquefaction and gasification technology); 4) hydrogen energy (technology for production, transport, storage and utilization of hydrogen); 5) others (wind power and ocean thermal power generation). 7 figs., 3 tabs.

  8. Recent progress in the NDE of cast ship propulsion components

    Science.gov (United States)

    Spies, Martin; Rieder, Hans; Dillhöfer, Alexander; Rauhut, Markus; Taeubner, Kai; Kreier, Peter

    2014-02-01

    The failure of propulsion components of ships and ferries can lead to serious environmental and economic damage or even the loss of lives. For ultrasonic inspection of such large components we employ mechanized scanning and defect reconstruction using the Synthetic Aperture Focusing Technique (SAFT). We report on results obtained in view of the detection of defects with different inspection techniques. Also, we address the issue of Probability of Detection by reporting results obtained in POD and MAPOD-studies (Model-Assisted POD) using experimental and simulated data. Finally, we show recent results of surface and sub-surface inspection using optical and eddy current techniques.

  9. Design and development of DC high current sensor using Hall-Effect method

    Science.gov (United States)

    Dewi, Sasti Dwi Tungga; Panatarani, C.; Joni, I. Made

    2016-02-01

    This paper report a newly developed high DC current sensor by using a Hall effect method and also the measurement system. The Hall effect sensor receive the magnetic field generated by a current carrying conductor wire. The SS49E (Honeywell) magnetoresistive sensor was employed to sense the magnetic field from the field concentrator. The voltage received from SS49E then converted into digital by using analog to digital converter (ADC-10 bit). The digital data then processed in the microcontroller to be displayed as the value of the electric current in the LCD display. In addition the measurement was interfaced into Personal Computer (PC) using the communication protocols of RS232 which was finally displayed in real-time graphical form on the PC display. The performance test on the range ± 40 Ampere showed that the maximum relative error is 5.26%. It is concluded that the sensors and the measurement system worked properly according to the design with acceptable accuracy.

  10. Development of a Magnetostrictive FeNi Coated Surface Acoustic Wave Current Sensor

    Directory of Open Access Journals (Sweden)

    Jie Tong

    2017-07-01

    Full Text Available A magnetostrictive FeNi-coated surface acoustic wave (SAW-based current sensor was proposed in this work. The weak remanence and hysteresis effect of the FeNi itself contributes to suppress the asymmetry in sensor response at increasing and decreasing current. The sensor response was simulated by solving the coupled electromechanical field equation in layered structure considering the magnetostrictive effect and an approach of effective dielectric constant. The effects from the aspect ratio and thickness of the FeNi film on sensor response were analyzed to determine the optimal design parameters. Differential oscillation structure was used to form the sensor, in which, the FeNi thin film was deposited along the SAW propagation of the sensor chip by using RF magnetron sputtering. The magnetostrictive effect of the FeNi coating induced by the magnetic loading generates the perturbation in SAW velocity, and corresponding oscillation frequency. High sensitivity of 10.7 KHz/A, good linearity and repeatability, lower hysteresis error of 0.97% were obtained from the developed prototype 150 MHz SAW FeNi coated current sensor.

  11. Pruning-induced tylose development in stems of current-year shoots of Vitis vinifera (Vitaceae).

    Science.gov (United States)

    Sun, Qiang; Rost, Thomas L; Matthews, Mark A

    2006-11-01

    Tyloses form in xylem vessels in response to various environmental stimuli, but little is known of the kinetics or regulation of their development. Preliminary investigations indicated that wounds seal quickly with tyloses after pruning of grapevine shoots. In this study, tylose development was analyzed qualitatively and quantitatively at different depths and times from pruning cuts along current-year shoots of grapevines at basal, middle, and apical stem regions. Tyloses developed simultaneously within a single vessel but much separated in time among vessels. Pruning caused prodigious tylosis in vessels of grape stems, extending to approximately 1 cm deep and to 7 d after wounding, but about half of the vessels did not become completely occluded. The fraction of vessels forming tyloses was greatest in basal (85%) and least in apical (50%) regions. The depth of maximum density of tyloses was 4 mm from the cut in the basal region and 2 mm from the cut in the middle and apical regions. Tylose development was faster in the basal and middle than in the apical region. The pattern of tylose development is discussed in the context of wound repair and pathogen movement in grapevines.

  12. Current status of technology development for fabrication of Indian Test Blanket Module (TBM) of ITER

    Energy Technology Data Exchange (ETDEWEB)

    Jayakumar, T., E-mail: tjk@igcar.gov.in [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam 603102 (India); Rajendra Kumar, E. [TBM Division, Institute for Plasma Research (IPR), Bhat, Gandhinagar 382428 (India)

    2014-10-15

    Highlights: • Status of technology developments for Indian TBM to be installed in ITER is presented. • Procedure development for EB, laser and laser-hybrid welding of RAFM steel presented. • Filler wires for RAFM steel for TIG, NG-TIG and laser-hybrid welding have been developed. • Feasibility of production of channel plate by HIP technology has been demonstrated. - Abstract: Ever since India decided to install its Lead-Lithium Ceramic Breeder (LLCB) TBM in ITER, various technologies for fabrication of Indian TBM are being pursued by IPR and IGCAR, in collaboration with various research laboratories in India. Welding consumables for joining India specific RAFM steels (IN-RAFMS), procedures for hot isostatic pressing, electron beam welding, laser and laser-hybrid welding have been developed. Considering the complex nature and limited access available for inspection, innovative inspection procedures that involved use of phased array ultrasonic and C-scan imaging are also being pursued. This paper presents the current status of these developments and provides a roadmap for the future activities planned in realizing Indian TBM for testing in ITER.

  13. Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.

    Science.gov (United States)

    Zhan, Peng; Pannecouque, Christophe; De Clercq, Erik; Liu, Xinyong

    2016-04-14

    The early effectiveness of combinatorial antiretroviral therapy (cART) in the treatment of HIV infection has been compromised to some extent by rapid development of multidrug-resistant HIV strains, poor bioavailability, and cumulative toxicities, and so there is a need for alternative strategies of antiretroviral drug discovery and additional therapeutic agents with novel action modes or targets. From this perspective, we first review current strategies of antiretroviral drug discovery and optimization, with the aid of selected examples from the recent literature. We highlight the development of phosphate ester-based prodrugs as a means to improve the aqueous solubility of HIV inhibitors, and the introduction of the substrate envelope hypothesis as a new approach for overcoming HIV drug resistance. Finally, we discuss future directions for research, including opportunities for exploitation of novel antiretroviral targets, and the strategy of activation of latent HIV reservoirs as a means to eradicate the virus.

  14. Loss of muscle mass: Current developments in cachexia and sarcopenia focused on biomarkers and treatment.

    Science.gov (United States)

    Drescher, Cathleen; Konishi, Masaaki; Ebner, Nicole; Springer, Jochen

    2016-01-01

    Loss of muscle mass arises from an imbalance of protein synthesis and protein degradation. Potential triggers of muscle wasting and function are immobilization, loss of appetite, dystrophies and chronic diseases as well as aging. All these conditions lead to increased morbidity and mortality in patients, which makes it a timely matter to find new biomarkers to get a fast clinical diagnosis and to develop new therapies. This mini-review covers current developments in the field of biomarkers and drugs on cachexia and sarcopenia. Here, we reported about promising markers, e.g. tartrate-resistant acid phosphatase 5a (TRACP5a), and novel substances like Epigallocatechin-3-gallate (EGCg). In summary, the progress to combat muscle wasting is in full swing and perhaps diagnosis of muscle atrophy and of course patient treatments could be soon supported by improved and more helpful strategies.

  15. Virtuous and Vicious Circles: Lessons for Current European Policies from Italian Post-War Development

    Directory of Open Access Journals (Sweden)

    Gioacchino Garofoli

    2017-06-01

    Full Text Available The paper deals with the Italian economic development, explaining the main features and the crucial variables in the long-term transformation process. The Italian economy has been analysed taking into account the different and changing international rules in medium and long-term to understand their role on the development strategies and on the changing competitive position of the country. The comparative international analysis on selected crucial variables shows some contradictions between expectations and effective outcomes of changing institutional rules and introduced economic policies. This underlines both the emergence of unexpected trajectories and economic performances and the lasting of structural differences among European countries. The selection of consistent economic policies in Europe, then, should take into account these phenomena. The paper underlines the crucial role of long-term economic analysis to fully understand not only the crucial structural variables but even opportunities and challenges for strategic decisions in the current economic crisis.

  16. Continuing professional development in nursing in Australia: current awareness, practice and future directions.

    Science.gov (United States)

    Katsikitis, Mary; McAllister, Margaret; Sharman, Rachael; Raith, Lisa; Faithfull-Byrne, Annette; Priaulx, Rae

    2013-08-01

    Australian nurses and midwives are expected to compile a professional development portfolio during their annual registration process. This study aimed to ascertain the current understanding, practice and future continuing professional development (CPD) needs of nurses and midwives employed in a regional area of Queensland, Australia. Perceived barriers and incentives for CPD were also measured. 289 public and private hospital nurses and midwives responded to the survey. Results showed that participants understood the new requirements, valued ongoing learning, preferred education to occur within work hours, and considered their workplaces as accepting of change. Approximately two-thirds of participants believed CPD should be shared between them and their employers. Barriers to undertaking CPD included understaffing, and the concern that CPD would interfere with time outside work. Organisational support positively influenced attitudes to CPD. This study highlights the importance of supportive management in encouraging their workforce to embrace ongoing learning and change.

  17. Inclusive pedagogy in Australian universities: A review of current policies and professional development activities

    Directory of Open Access Journals (Sweden)

    Danielle Hitch

    2015-03-01

    Full Text Available This article reports on activities undertaken by Australian universities to support academic staff to provide inclusive teaching. The findings of two lines of inquiry are reported - a desktop audit of the presence of inclusive teaching or universal design for learning (UDL in publically available policies and procedures documents, and a survey of the methods adopted to build staff capacity to provide inclusive teaching and learning. Just over a third (34.21% of Australian universities referred to inclusive teaching or UDL in their policies and procedures. A wide range of current practices in professional development for inclusive teaching was reported, with the most frequent being one-off workshops focussing on accommodating specific groups of students. Improved institutional support through policies, procedures and professional development would enable Australian higher education teachers to provide quality inclusive teaching to all students.

  18. Development and Testing of a Transmission Voltage SuperLimiter™ Fault Current Limiter

    Energy Technology Data Exchange (ETDEWEB)

    Romanosky, Walter [American Superconductor Corporation, Devens, MA (United States)

    2012-09-01

    This report summarizes work by American Superconductor (AMSC), Los Alamos National Laboratory (LANL), Nexans, Siemens and Southern California Edison on a 138kV resistive type high temperature superconductor (HTS) fault current limiter (FCL) under a cooperative agreement with the U.S. Department of Energy (DOE). Phase 1A encompassed core technology development and system design and was previously reported (see summary that follows in Section 1.1 of the Introduction). This report primarily discusses work performed during Phase 1B, and addresses the fabrication and test of a single-phase prototype FCL. The results are presented along with a discussion of requirements/specifications and lessons learned to aid future development and product commercialization.

  19. Current situation and development tendency of thermal spraying materials in China

    Institute of Scientific and Technical Information of China (English)

    YU; Yue-guang

    2005-01-01

    The current situations of thermal spraying materials in China are described in this paper.The thermal spraying technology in China has a great progress over tens of years. More than one hundred varieties of material products serve thermal spraying producing now. They belong to three kinds, powders,wires and rods. Technologies for producing alloy, ceramic and composite powders, alloy and cored wires,and oxide ceramic rods are applied to large-scale production. Many research and development works on advanced materials for thermal spraying are carrying out recent years. They show that the general tendencies of thermal spraying materials in China are composite or low-impurity component, ultrafine or nanosized microstructure, high properties, and specialized and systematized applications. Thermal spraying materials have great prospects with the development of saving society in China.

  20. [Methodology for the development and update of practice guidelines: current state].

    Science.gov (United States)

    Barrera-Cruz, Antonio; Viniegra-Osorio, Arturo; Valenzuela-Flores, Adriana Abigail; Torres-Arreola, Laura Pilar; Dávila-Torres, Javier

    2016-01-01

    The current scenario of health services in Mexico reveals as a priority the implementation of strategies that allow us to better respond to the needs and expectations of individuals and society as a whole, through the provision of efficient and effective alternatives for the prevention, diagnosis and treatment of diseases. In this context, clinical practice guidelines constitute an element of management in the health care system, whose objective is to establish a national bechmark for encouraging clinical and management decision making, based on recommendations from the best available evidence, in order to contribute to the quality and effectiveness of health care. The purpose of this document is to show the methodology used for the development and updating of clinical practice guidelines that the Instituto Mexicano del Seguro Social has developed in line with the sectorial model in order to serve the user of these guidelines.

  1. Current Situation and Suggestions of Decorative Fishery Development in Hainan Province

    Institute of Scientific and Technical Information of China (English)

    Xi; ZHANG; Ning; YANG; Hai; HUANG

    2013-01-01

    Decorative fishery is an important part of recreational fisheries,Hainan has the potential to develop decorative fishery.In this paper,on the basis of the deep-going survey on the current situation of decorative fishery development in Hainan,the main questions of decorative fish cultivation and market were discussed.At the same time,many suggestions were brought up,such as exploiting the biological resources of Hainan Island,strengthening scientific research efforts,introducing new varieties of ornamental species,strengthening industrial guidance and market management,etc.,which will benefit the rational utilization of tropical biological resources and increase the whole competitive advantage of decorative fishery in Hainan Province.

  2. Development of a vaccine for Chlamydia trachomatis: challenges and current progress

    Directory of Open Access Journals (Sweden)

    Hafner LM

    2015-08-01

    Full Text Available Louise M Hafner,1 Peter Timms2 1School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, 2Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, QLD, Australia Abstract: Chlamydia trachomatis remains an enigmatic bacterial pathogen with no vaccine yet available to treat human ocular and genital tract infections caused by tissue-tropic serovars of the organism. Globally, it is the leading cause of preventable blindness as well as the leading cause of bacterial sexually transmitted infections. The pathogen has a range of virulence factors that enable it to successfully evade both the innate and adaptive immune system of the host. The host immune system, although protective, paradoxically is also associated closely with the pathologies of trachoma and pelvic inflammatory disease – disease sequelae of some chlamydial infections and reinfections in some genetically susceptible hosts. In this review, we focus on what is known currently about the pathogenesis of ocular and genital infections caused by this mucosal pathogen. We also discuss novel insights into the pathogenesis of infections caused by the genital and ocular serovars of C. trachomatis, including a discussion of both pathogen and host factors, such as the human microbiota at these mucosal sites as well as the current immunological challenges facing vaccine development. Finally, we discuss the current progress toward development of a vaccine against C. trachomatis. A wide range of recombinant protein antigens are being identified and, hence, are available for vaccine trials. A plasmid-free live strain has recently been produced and evaluated in the mouse (Chlamydia muridarum and monkey (C. trachomatis models. The data for ocular infections in the monkey model was particularly encouraging, although the path to regulatory approval of a live vaccine is

  3. Current Development Status of a Particle Size Analyzer for Coated Particle Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Andrew T [ORNL; Hunn, John D [ORNL; Karnowski, Thomas Paul [ORNL

    2007-08-01

    Work was performed to develop a prototype Particle Size Analyzer (PSA) for application to coated particle fuel characterization. This system was based on a light obscuration method and targeted towards high throughput analysis. Although never matured to the point of replacing existing lower throughput optical microscopy shadowgraph methods, the system was successfully applied to automating the counting of large particle samples for increased accuracy in calculating mean particle properties based on measurements of multiparticle samples. The measurement of particle size with the PSA was compared to current shadowgraph techniques and found to result in considerably greater throughput at the cost of larger measurement uncertainty. The current algorithm used by the PSA is more sensitive to particle shape and this is a likely cause of the greater uncertainty when attempting to measure average particle diameter. The use of the PSA to measure particle shape will require further development. Particle transport through the PSA and stability of the light source/detector are key elements in the successful application of this technique. A number of system pitfalls were studied and addressed.

  4. Drug development for the irritable bowel syndrome: current challenges and future perspectives

    Directory of Open Access Journals (Sweden)

    Fabrizio eDe Ponti

    2013-02-01

    Full Text Available Medications are frequently used for the treatment of patients with the irritable bowel syndrome (IBS, although their actual benefit is often debated. In fact, the recent progress in our understanding of the pathophysiology of IBS, accompanied by a large number of preclinical and clinical studies of new drugs, has not been matched by a significant improvement of the armamentarium of medications available to treat IBS. The aim of this review is to outline the current challenges in drug development for IBS, taking advantage of what we have learnt through the Rome process (Rome I, Rome II and Rome III. The key questions that will be addressed are: a do we still believe in the "magic bullet", i.e. a very selective drug displaying a single receptor mechanism capable of controlling IBS symptoms? b IBS is a "functional disorder" where complex neuroimmune and brain-gut interactions occur and minimal inflammation is often documented: do we need to target gut motility, visceral sensitivity or minimal inflammation? c are there validated biomarkers (accepted by regulatory agencies for studies of sensation and motility with experimental medications in humans? d do animal models have predictive and translational value? d in the era of personalised medicine, does pharmacogenomics applied to these medications already play a role? Finally, this review will briefly outline medications currently used or in development for IBS. It is anticipated that a more focussed interaction between basic science investigators, pharmacologists and clinicians will lead to better treatment of IBS.

  5. Development of wide range current signal data acquisition system for reactivity meter using Keithley electrometers

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, S. H.; Kim, H. K.; Chio, Y. S.; Kim, M. J.; Woo, J. S. [KAERI, Taejon (Korea, Republic of)

    2001-05-01

    The reactivity worth of control rods is measured to ensure safety every refueling phase in HANARO, the research reactor in KAERI. Two compensated ion chambers are installed around the outer core to measure the reactor power. The signals from CICs enter the reactivity computer system. The reactivity computer system operated on MS-DOS was developed during the commissioning phase. But it is not so user-friendly, is so outdated and difficult to aquire spare parts. Hence we decided to upgrade the system to utilize MS-Windows {sup TM} operating system and object oriented visual program language. This paper describes the data acquisition system developed for the new reactivity computer system operated on MS-Windows{sup TM} operating system. This data acquisition system uses electrometers for converting low current signal to voltage and measures the current signal accurately even though the electrometer change the range of the output automatically. We verified that the system was stable and acquired the input signals accurately.

  6. The epidemic of HIV/AIDS in developing countries; the current scenario in Pakistan

    Directory of Open Access Journals (Sweden)

    Babar Masroor E

    2011-08-01

    Full Text Available Abstract HIV (Human Immunodeficiency virus causes (acquired immunodeficiency syndrome AIDS, in which the immune system of body totally fails to develop any defense against the foreign invaders. Infection with HIV occurs by transfer of blood, semen, and breast milk. HIV/AIDS is a global problem and it results nearly 25 million deaths worldwide. Developing countries like Pakistan have issues regarding Public Health. Currently, epidemic of HIV/AIDS is established in Pakistan and there is a threat of an expanded HIV/AIDS outbreak in the country. The major reason is that population is engaging in high-risk practices, low awareness about HIV/AIDS, and treacherous blood transfusion practices. A supplementary threat to Pakistan is India because both sharing a border and India is facing a rapidly growing HIV/AIDS epidemic. Local NGOs, National and International organizations are warning that in near future Pakistan may experiences bad situation regarding HIV/AIDS. In the present article we focused current situation of surveillance of HIV/AIDS, its virology, genotype, diagnostics, high-risk groups, reasons of vulnerability in Pakistani population, and the role of different national and international organizations in this situation.

  7. Technical support to the Solvent Refined Coal (SRC) demonstration projects: assessment of current research and development

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, M.S.; Rodgers, B.R.; Brown, C.H.; Carlson, P.K.; Gambill, W.R.; Gilliam, T.M.; Holmes, J.M.; Krishnan, R.P.; Parsly, L.F.

    1980-12-01

    A program to demonstrate Solvent Refined Coal (SRC) technology has been initiated by the US Department of Energy (DOE) in partnership with two industrial groups. Project management responsibility has been assigned to the Oak Ridge Operations Office (ORO) of DOE. ORO requested that the Oak Ridge National Laboratory assess current research and development (R and D) activities and develop recommendations for those activities that might contribute to successful completion of the SRC demonstration plant projects. The objectives of this final report are to discuss in detail the problem areas in SRC; to discuss the current and planned R and D investigations relevant to the problems identified; and to suggest appropriate R and D activities in support of designs for the SRC demonstration plants. Four types of R and D activities are suggested: continuation of present and planned activities; coordination of activities and results, present and proposed; extension/redirection of activities not involving major equipment purchase or modifications; and new activities. Important examples of the first type of activity include continuation of fired heater, slurry rheology, and slurry mixing studies at Ft. Lewis. Among the second type of activity, coordination of data acquisition and interpretation is recommended in the areas of heat transfer, vapor/liquid equilibria, and physical properties. Principal examples of recommendations for extension/redirection include screening studies at laboratory scale on the use of carbonaceous precoat (e.g., anthracite) infiltration, and 15- to 30-day continuous tests of the Texaco gasifier at the Texaco Montebello facility (using SRC residues).

  8. CURRENT TRENDS FOR DEVELOPMENT AND IMPROVEMENT OF THE ORGANIZATIONAL STRUCTURES IN MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Angel Doraliyski

    2017-03-01

    Full Text Available One of the key components of the management system is the organizational structure of management. This report presents the current trends of development and improvement of organizational structures of management. The semantics of the term "organizational structure" used in the report is clarified. Key aspects of structural policy of organizations are discussed, as well as the introduction of flexible organizational forms. The main directions for analysis of organizational policy of organizations are also mentioned. It is stressed that the analysis of current trends for the future development of organizational structures of management should be an integral component of the management policy of every organization. The trends are flexibility and adaptability of the organizational structure, rational proportion between centralization and decentralization, an appropriate balance between the rights, duties and responsibilities, reducing regulations, rules and other normative documents. A recommendetaion is made that organizational governance structures must be adapted constantly in accordance with changes in the overall management system, as they are one of its main components.

  9. JSC Advanced Curation: Research and Development for Current Collections and Future Sample Return Mission Demands

    Science.gov (United States)

    Fries, M. D.; Allen, C. C.; Calaway, M. J.; Evans, C. A.; Stansbery, E. K.

    2015-01-01

    Curation of NASA's astromaterials sample collections is a demanding and evolving activity that supports valuable science from NASA missions for generations, long after the samples are returned to Earth. For example, NASA continues to loan hundreds of Apollo program samples to investigators every year and those samples are often analyzed using instruments that did not exist at the time of the Apollo missions themselves. The samples are curated in a manner that minimizes overall contamination, enabling clean, new high-sensitivity measurements and new science results over 40 years after their return to Earth. As our exploration of the Solar System progresses, upcoming and future NASA sample return missions will return new samples with stringent contamination control, sample environmental control, and Planetary Protection requirements. Therefore, an essential element of a healthy astromaterials curation program is a research and development (R&D) effort that characterizes and employs new technologies to maintain current collections and enable new missions - an Advanced Curation effort. JSC's Astromaterials Acquisition & Curation Office is continually performing Advanced Curation research, identifying and defining knowledge gaps about research, development, and validation/verification topics that are critical to support current and future NASA astromaterials sample collections. The following are highlighted knowledge gaps and research opportunities.

  10. GIBSI: an integrated modelling system for watershed management – sample applications and current developments

    Directory of Open Access Journals (Sweden)

    A. N. Rousseau

    2007-11-01

    Full Text Available Hydrological and pollutant fate models have long been developed for research purposes. Today, they find an application in integrated watershed management, as decision support systems (DSS. GIBSI is such a DSS designed to assist stakeholders in watershed management. It includes a watershed database coupled to a GIS and accessible through a user-friendly interface, as well as modelling tools that simulate, on a daily time step, hydrological processes such as evapotranspiration, runoff, soil erosion, agricultural pollutant transport and surface water quality. Therefore, GIBSI can be used to assess a priori the effect of management scenarios (reservoirs, land use, waste water effluents, diffuse sources of pollution that is agricultural pollution on surface hydrology and water quality. For illustration purposes, this paper presents several management-oriented applications using GIBSI on the 6680 km2 Chaudière River watershed, located near Quebec City (Canada. They include impact assessments of: (i municipal clean water program; (ii agricultural nutrient management scenarios; (iii past and future land use changes, as well as (iv determination of achievable performance standards of pesticides management practices. Current and future developments of GIBSI are also presented as these will extend current uses of this tool and make it useable and applicable by stakeholders on other watersheds. Finally, the conclusion emphasizes some of the challenges that remain for a better use of DSS in integrated watershed management.

  11. Development of (Nb,Ta3Sn multifilamentary superconductor wire for high current applications

    Directory of Open Access Journals (Sweden)

    Rodrigues Jr. Durval

    2000-01-01

    Full Text Available The optimization of the energy generated by a MagnetoHydroDynamic (MHD channel using a superconducting magnet demands the optimization of the magnetic field of the system and of the critical points on the magnet winding. This work must include the development of a high performance superconductor wire suitable for this system. Aiming to the construction of improved performance MHD channel, it was developed a low cost superconductor wire, with the required characteristics. The wire was made using a technology compatible with the assembling steps and heat treatment conditions of the MHD superconducting magnets fabrication. It was used the internal Sn method in Nb-7.5wt%Ta tube to fabricate a 271-filament wire with a diameter of 0.81 mm and a Cu/nonCu ratio of 2.3. The wire was heat treated at 200 °C to diffuse the Sn into the Cu shell, producing bronze, followed by the final reaction at temperatures ranging from 670 °C to 730 °C during 25 to 150 h, to produce (Nb,Ta3Sn. The superconducting wire characterization was made measuring the critical current Ic versus the applied magnetic field in the range of 5 to 20 T, the critical temperature Tc and the residual resistivity ratio (RRR. The wire transported critical currents above those available in commercial superconducting wires. These values of Ic are higher than the expected values for the optimization of the MHD channel.

  12. The Metabolism of Anticancer Drugs by the Liver: Current Approaches to the Drug Development Process.

    Science.gov (United States)

    Belka, Mariusz; Bączek, Tomasz

    2015-01-01

    The worldwide scientific community is in agreement that the activities of metabolic enzymes greatly impact the efficacies of anticancer drugs. Elucidation of the influences of these drugs on metabolism, especially that occurring in the liver, appears to be an extremely important step in the development of new anticancer drugs. Considering the continuous need to search for safe and effective chemotherapeutics, studies of the metabolism of new potent drugs are very important and should be included in the modern, innovative drug development pipeline. This article summarizes most of the current metabolic case studies involving anticancer drug development. Firstly, the impacts of diverse metabolic enzymes, particularly cytochrome P450, and the utilities of a few model in vitro enzymatic systems are described. Then, different analytical techniques, with particular emphasis on liquid chromatography- mass spectrometry detection and structural elucidation, are discussed. Finally, some computer-aided strategies for decision making in the drug design process are described. Recent advances in drug development, including microdosing, in vitro-in vivo correlation and pharmacologic audit trail, are also discussed in relation to metabolic studies.

  13. Comprehensive review in current developments of imidazole-based medicinal chemistry.

    Science.gov (United States)

    Zhang, Ling; Peng, Xin-Mei; Damu, Guri L V; Geng, Rong-Xia; Zhou, Cheng-He

    2014-03-01

    Imidazole ring is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron-rich characteristic is beneficial for imidazole derivatives to readily bind with a variety of enzymes and receptors in biological systems through diverse weak interactions, thereby exhibiting broad bioactivities. The related research and developments of imidazole-based medicinal chemistry have become a rapidly developing and increasingly active topic. Particularly, numerous imidazole-based compounds as clinical drugs have been extensively used in the clinic to treat various types of diseases with high therapeutic potency, which have shown the enormous development value. This work systematically gives a comprehensive review in current developments of imidazole-based compounds in the whole range of medicinal chemistry as anticancer, antifungal, antibacterial, antitubercular, anti-inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents, together with their potential applications in diagnostics and pathology. It is hoped that this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic imidazole-based medicinal drugs, as well as more effective diagnostic agents and pathologic probes.

  14. Evaluation of current trends and recent development in insulin therapy for management of diabetes mellitus.

    Science.gov (United States)

    Nawaz, Muhammad Sarfraz; Shah, Kifayat Ullah; Khan, Tahir Mehmood; Rehman, Asim Ur; Rashid, Haroon Ur; Mahmood, Sajid; Khan, Shahzeb; Farrukh, Muhammad Junaid

    2017-07-08

    Diabetes mellitus is a major health problem in developing countries. There are various insulin therapies to manage diabetes mellitus. This systematic review evaluates various insulin therapies for management of diabetes mellitus worldwide. This review also focuses on recent developments being explored for better management of diabetes mellitus. We reviewed a number of published articles from 2002 to 2016 to find out the appropriate management of diabetes mellitus. The paramount parameters of the selected studies include the insulin type & its dose, type of diabetes, duration and comparison of different insulin protocols. In addition, various newly developed approaches for insulin delivery with potential output have also been evaluated. A great variability was observed in managing diabetes mellitus through insulin therapy and the important controlling factors found for this therapy include; dose titration, duration of insulin use, type of insulin used and combination therapy of different insulin. A range of research articles on current trends and recent advances in insulin has been summarized, which led us to the conclusion that multiple daily insulin injections or continuous subcutaneous insulin infusion (insulin pump) is the best method to manage diabetes mellitus. In future perspectives, development of the oral and inhalant insulin would be a tremendous breakthrough in Insulin therapy. Copyright © 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  15. Liposomal Drug Product Development and Quality: Current US Experience and Perspective.

    Science.gov (United States)

    Kapoor, Mamta; Lee, Sau L; Tyner, Katherine M

    2017-02-03

    Research in the area of liposomes has grown substantially in the past few decades. Liposomes are lipid bilayer structures that can incorporate drug substances to modify the drug's pharmacokinetic profile thereby improving drug delivery. The agency has received over 400 liposomal drug product submissions (excluding combination therapies), and there are currently eight approved liposomal drug products on the US market. In order to identify the pain points in development and manufacturing of liposomal drug products, a retrospective analysis was performed from a quality perspective on submissions for new and generic liposomal drug products. General analysis on liposomal drug product submissions was also performed. Results indicated that 96% of the submissions were Investigational New Drug (IND) applications, 3% were New Drug Applications (NDAs), and the remaining 1% was Abbreviated New Drug Applications (ANDAs). Doxorubicin hydrochloride was the most commonly used drug substance incorporated into the liposomes (31%). The majority of the liposomal products were administered via intravenous route (84%) with cancer (various types) being the most common indication (63%). From a quality perspective, major challenges during the development of liposomal drug products included identification and (appropriate) characterization of critical quality attributes of liposomal drug products and suitable control strategies during product development. By focusing on these areas, a faster and more efficient development of liposomal drug products may be achieved. Additionally, in this way, the drug review process for such products can be streamlined.

  16. Current insights in the development of children’s motor imagery ability

    Directory of Open Access Journals (Sweden)

    Steffie eSpruijt

    2015-06-01

    Full Text Available Over the last two decades, the number of studies on motor imagery in children has witnessed a large expansion. Most studies used the hand laterality judgment paradigm or the mental chronometry paradigm to examine motor imagery ability. The main objective of the current review is to collate these studies to provide a more comprehensive insight in children’s motor imagery development and its age of onset. Motor imagery is a form of motor cognition and aligns with forward (or predictive models of motor control. Studying age-related differences in motor imagery ability in children therefore provides insight in underlying processes of motor development during childhood. Another motivation for studying age-related differences in motor imagery is that in order to effectively apply motor imagery training in children (with motor impairments, it is pertinent to first establish the age at which children are actually able to perform motor imagery.Overall, performance in the imagery tasks develops between 5 and 12 years of age. The age of motor imagery onset, however, remains equivocal, as some studies indicate that children of 5 to 7 years old can already enlist motor imagery in an implicit motor imagery task, whereas other studies using explicit instructions revealed that children do not use motor imagery before the age of 10. From the findings of the current study, we can conclude that motor imagery training is potentially a feasible method for paediatric rehabilitation in children from 5 years on. We suggest that younger children are most likely to benefit from motor imagery training that is presented in an implicit way. Action observation training might be a beneficial adjunct to implicit motor imagery training. From 10 years of age, more explicit forms of motor imagery training can be effectively used.

  17. Development of nondestructive evaluation techniques for high-temperature ceramic heat exchanger components. Tenth quarterly report, January-March 1980

    Energy Technology Data Exchange (ETDEWEB)

    Kupperman, D.S.; Yuhas, D.; Caines, M.J.

    1980-04-01

    The effectiveness of several conventional and unconventional NDE techniques for specific high-temperature ceramic components was determined. Techniques under study at ANL include dye-enhanced radiography, acoustic microscopy, conventional ultrasonic testing, acoustic-emission detection, acoustic impact testing, holography, interferometry, infrared scanning, internal friction measurements, and overload proof testing. The current effort involves SiC heat-exchanger tubes; previous ceramic NDE efforts at ANL have involved silicon-nitride gas-turbine rotors. Recent results on inspection of SiC heat-exchanger tubing by means of ultrasonic acoustic microscopy techniques and efforts initiated and planned for NDE of ceramic joints are discussed.

  18. Current knowledge of tooth development: patterning and mineralization of the murine dentition.

    Science.gov (United States)

    Catón, Javier; Tucker, Abigail S

    2009-04-01

    The integument forms a number of different types of mineralized element, including dermal denticles, scutes, ganoid scales, elasmoid scales, fin rays and osteoderms found in certain fish, reptiles, amphibians and xenarthran mammals. To this list can be added teeth, which are far more widely represented and studied than any of the other mineralized elements mentioned above, and as such can be thought of as a model mineralized system. In recent years the focus for studies on tooth development has been the mouse, with a wealth of genetic information accrued and the availability of cutting edge techniques. It is the mouse dentition that this review will concentrate on. The development of the tooth will be followed, looking at what controls the shape of the tooth and how signals from the mesenchyme and epithelium interact to lead to formation of a molar or incisor. The number of teeth generated will then be investigated, looking at how tooth germ number can be reduced or increased by apoptosis, fusion of tooth germs, creation of new tooth germs, and the generation of additional teeth from existing tooth germs. The development of mineralized tissue will then be detailed, looking at how the asymmetrical deposition of enamel is controlled in the mouse incisor. The continued importance of epithelial-mesenchymal interactions at these later stages of tooth development will also be discussed. Tooth anomalies and human disorders have been well covered by recent reviews, therefore in this paper we wish to present a classical review of current knowledge of tooth development, fitting together data from a large number of recent research papers to draw general conclusions about tooth development.

  19. Nondestructive Evaluation (NDE) of structural ceramics by photoacoustic microscopy

    Science.gov (United States)

    Khandelwal, P. K.

    1986-01-01

    Photoacoustic microscopy (PAM) was utilized to detect surface and subsurface defects in structural ceramic materials. A computerized PAM data acquisition, color imaging and analysis system was developed and used. Subsurface simulated cylindrical holes can be detected to about 1 mm below the interrograting surface. Simulated tight surface cracks of 96 microns length and 48 microns depth can be detected in these materials under optimum conditions.

  20. FEN VE TEKNOLOJİ DERSLERİNDE GAZETELERİN KULLANILMASI

    OpenAIRE

    BULUŞ KIRIKKAYA, Esma; Bozkurt, Esra; İŞERİ, Şebnem

    2013-01-01

    Topics in science and technology course’s topics are related closely to daily life. Therefore, relating science and technology course to daily life makes lessons entertaining and makes students to develop positive attitudes towards science. Being the aims of science and technology course for establishing relationship with daily life and being the newspapers including data about this course’s aims, shows this course’s relevance with using newspaper. In this research, it was aimed to emphasizin...

  1. Instrumentation, Monitoring and NDE for New Fast Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Bond, Leonard J.; Doctor, Steven R.; Bunch, Kyle J.; Good, Morris S.; Waltar, Alan E.

    2007-07-28

    The Global Nuclear Energy Partnership (GNEP) has been proposed as a viable system in which to close the fuel cycle in a manner consistent with markedly expanding the global role of nuclear power while significantly reducing proliferation risks. A key part of this system relies on the development of actinide transmutation, which can only be effectively accomplished in a fast-spectrum reactor. The fundamental physics for fast reactors is well established. However, to achieve higher standards of safety and reliability, operate with longer intervals between outages, and achieve high operating capacity factors, new instrumentation and on-line monitoring capabilities will be required--during both fabrication and operation. Since the Fast Flux Test Facility (FFTF) and Experimental Breeder Reactor – II (EBR-II) reactors were operational in the USA, there have been major advances in instrumentation, not the least being the move to digital systems. Some specific capabilities have been developed outside the USA, but new or at least re-established capabilities will be required. In many cases the only available information is in reports and papers. New and improved sensors and instrumentation will be required. Advanced instrumentation has been developed for high-temperature/high-flux conditions in some cases, but most of the original researchers and manufacturers are retired or no longer in business.

  2. An implementation of signal processing algorithms for ultrasonic NDE

    Energy Technology Data Exchange (ETDEWEB)

    Ericsson, L.; Stepinski, T. [Uppsala Univ. (Sweden). Dept. of Technology, Circuits and Systems

    1994-12-31

    Probability of detection flaws during ultrasonic pulse-echo inspection is often limited by the presence of backscattered echoes from the material structure. A digital signal processing technique for removal of this material noise, referred to as split spectrum processing (SSP), has been developed and verified using laboratory experiments during the last decade. The authors have performed recently a limited scale evaluation of various SSP techniques for ultrasonic signals acquired during the inspection of welds in austenitic steel. They have obtained very encouraging results that indicate promising capabilities of the SSP for inspection of nuclear power plants. Thus, a more extensive investigation of the technique using large amounts of ultrasonic data is motivated. This analysis should employ different combinations of materials, flaws and transducers. Due to the considerable number of ultrasonic signals required to verify the technique for future practical use, a custom-made computer software is necessary. At the request of the Swedish nuclear power industry the authors have developed such a program package. The program provides a user-friendly graphical interface and is intended for processing of B-scan data in a flexible way. Assembled in the program are a number of signal processing algorithms including traditional Split Spectrum Processing and the more recent Cut Spectrum Processing algorithm developed by them. The program and some results obtained using the various algorithms are presented in the paper.

  3. Current use of contraceptive method among women in a middle-income developing country

    Directory of Open Access Journals (Sweden)

    Paul A Bourne

    2010-06-01

    Full Text Available Paul A Bourne1, Christopher AD Charles2,3, Tazhmoye V Crawford4, Maureen D Kerr-Campbell5, Cynthia G Francis1, Neva South-Bourne11Department of Community Health and Psychiatry, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston, Jamaica; 2King Graduate School, Monroe College, Bronx, New York, USA; 3Center for Victim Support, Harlem Hospital Center, New York; 4Basic Medical Sciences, Faculty of Medical Sciences, 5Systems Development Unit, Main Library, Faculty of Humanities and Education, The University of the West Indies, Mona, JamaicaBackground: Jamaica is a mid-range income developing country with an increasing population and public resource constraints. Therefore, reproductive health issues are of critical importance in Jamaica.Aim: We examined the use of contraceptives among women and the factors that influence these women to use contraceptives.Materials and method: In the current study we utilized the secondary dataset for the Reproductive Health Survey, conducted by the National Family Planning Board. The investigation was carried out with a stratified random sample of 7168 women aged between 15 and 49. The measures included demographic variables, method of contraception used, being in a relationship, number of partners, pregnancy status, and sexual activity status, along with other variables.Results: The majority of participants used some method of contraception (64%. The most popular method of contraception was a condom (32%. Results of a multivariate analysis suggests that the explanatory variables for the method of contraception used are age (OR = 0.98, 95% CI: 0.98–0.99, social class (OR = 0.83, 95% CI: 0.73–0.95, being in a relationship (OR = 3.35, 95% CI: 2.80–4.02, the rural–urban dichotomy (OR = 1.16, 95% CI: 1.02–1.32, being currently pregnant (OR = 0.01, 95% CI: 0.00–0.02, currently having sex (OR = 2.29, 95% CI: 1.95–2.70, number of partners (OR = 1.85, 95% CI: 1.57–2.17, the age at

  4. Viewpoint – Swimming against the Current: Questioning Development Policy and Practice

    Directory of Open Access Journals (Sweden)

    Kurt Mørck Jensen

    2013-06-01

    Full Text Available The water world is dominated by normative policies prescribing what 'good development' is all about. It is a universe of its own where policies live their own lives and feed in and out of each other. As new buzzwords continue to be invented or reinvented, policies continue to maintain their shiny images of how water resources or water supply should be managed. There are many water professionals acting as missionaries in the service of policies but probably fewer professionals acting up against blindfolded policy promotion. It is when water policies are being implemented in the real world that the trouble starts. In spite of their well-intended mission, water policies often suffer shipwreck on the socio-economic and political realities in developing countries. Through cases from India and the Mekong, the author demonstrates what happens when normative water polices are forced out of their comfort zone and into social and political realities. Although policies are made of stubborn material they need to be questioned through continuous analytical insight into developing country realities. But undertaking critical analysis and questioning the wisdom of water policies are easier said than done. It takes a lot of effort to swim against the policy current.

  5. On the development of a 15 mA direct current H - multicusp source

    Science.gov (United States)

    Kuo, T.; Yuan, D.; Jayamanna, K.; McDonald, M.; Baartman, R.; Schmor, P.; Dutto, G.

    1996-03-01

    A 15 mA dc H- multicusp source has been developed for injection into a TR30 cyclotron. This source is also used with a 900 kV tandem accelerator to obtain 10 mA protons at 1.8 MeV. The program is an extension of the 5-7 mA dc H- cusp source developed at TRIUMF during 1989-1990. Major efforts include the search for the optimal filament materials, shape, and location; comparison of cusp line confinement and magnetic filtering of electrons at the extraction region; optimization of extraction lense configuration; and upgrading of vacuum and power systems capability. The source is noncesiated and the maximum arc power available is only 5 kW. After the H- beams pass through an electron suppression grid and a 20 mm collimator, we obtained 15 mA with 0.66 π mm mrad 4 rms normalized emittance. At this output the e/H ratio was about 4. The best normalized emittance occurs around 5-7 mA, having a value of 0.37 π mm mrad. Further development in the near future is planned using cesium and multiple apertures in the hope of increasing dc H- currents to 30 mA while holding the normalized emittance below 0.75 π mm mrad.

  6. GM wheat development in China: current status and challenges to commercialization.

    Science.gov (United States)

    Xia, Lanqin; Ma, Youzhi; He, Yi; Jones, Huw D

    2012-03-01

    Genetic modification facilitates research into fundamental questions of plant functional genomics and provides a route for developing novel commercial varieties. In 2008, significant financial resources were supplied by the Chinese government for research and development (R&D) into genetic modification of the major crop species. This project was aimed at providing an opportunity for crop improvement while accentuating the development of a safe, precise, and effective wheat genetic transformation system suitable for commercialization. The focus here is on one of the key crops included in this project, wheat, to provide an insight into the main transformation methods currently in use, the target traits of major importance, and the successful applications of wheat genetic improvement in China. Furthermore, the biosafety and regulatory issues of major concern and the strategies to produce 'clean' transgenic wheat plants will also be discussed. This commentary is intended to be a helpful insight into the production and commercialization of transgenic wheat in China and to put these activities into a global context.

  7. A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry.

    Science.gov (United States)

    Keri, Rangappa S; Patil, Mahadeo R; Patil, Siddappa A; Budagumpi, Srinivasa

    2015-01-07

    Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds, which are common and integral feature of a variety of natural products and pharmaceutical agents. BTA shows a variety of pharmacological properties, and its analogs offer a high degree of structural diversity that has proven useful for the search of new therapeutic agents. The broad spectrum of pharmacological activity in individual BTA derivative indicates that, this series of compounds is of an undoubted interest. The related research and developments in BTA-based medicinal chemistry have become a rapidly developing and increasingly active topic. Particularly, numerous BTA-based compounds as clinical drugs have been extensively used in practice to treat various types of diseases with high therapeutic potency. This work systematically gives a comprehensive review in current developments of BTA-based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, antiinflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial and other medicinal agents. It is believed that, this review article is helpful for new thoughts in the quest for rational designs of more active and less toxic BTA-based drugs, as well as more effective diagnostic agents and pathologic probes.

  8. Energy service companies in European countries: Current status and a strategy to foster their development

    Energy Technology Data Exchange (ETDEWEB)

    Bertoldi, Paolo [European Commission, DG JRC, TP 450, I-21020 Ispra (Vatican City State, Holy See,) (Italy)]. E-mail: paolo.bertoldi@cec.eu.int; Rezessy, Silvia [Department of Environmental Sciences and Policy, Central European University, Nador u. 9, H-1051 Budapest (Hungary)]. E-mail: ephlas01@phd.ceu.hu; Vine, Edward [Lawrence Berkeley National Laboratory, Building 90-4000, Berkeley, CA 94720 (United States)]. E-mail: elvine@lbl.gov

    2006-09-15

    Although the European Commission and the Member States of the European Union (EU) have promoted a number of policy initiatives to foster the Energy Services Company (ESCO) industry, a recent survey of ESCO businesses in Europe has indicated that major differences exist in the development of the ESCO business among the various countries. In some countries a large number of ESCOs have been successfully operating for a number of years, while in other countries only a few ESCOs have recently started to operate. This difference could be explained by several factors, such as different levels of support offered to ESCOs by national and regional energy authorities, local market structures and rules, and variation in the definitions, roles and activities of ESCOs. This paper reviews and analyses the development and the current status of ESCO industries in the EU and the New Accession Countries. Based on the review and the analysis, a long-term strategy to foster the development of ESCOs in Europe is formulated. The strategic actions recommended build on successful experience in Europe and are proposed with an eye to existing and planned legislative measures, such as the proposed Energy Service Directive and the deployment of the Kyoto flexible mechanisms.

  9. Overview of current capabilities and research and technology developments for planetary protection

    Science.gov (United States)

    Frick, Andreas; Mogul, Rakesh; Stabekis, Pericles; Conley, Catharine A.; Ehrenfreund, Pascale

    2014-07-01

    The pace of scientific exploration of our solar system provides ever-increasing insights into potentially habitable environments, and associated concerns for their contamination by Earth organisms. Biological and organic-chemical contamination has been extensively considered by the COSPAR Panel on Planetary Protection (PPP) and has resulted in the internationally recognized regulations to which spacefaring nations adhere, and which have been in place for 40 years. The only successful Mars lander missions with system-level “sterilization” were the Viking landers in the 1970s. Since then different cleanliness requirements have been applied to spacecraft based on their destination, mission type, and scientific objectives. The Planetary Protection Subcommittee of the NASA Advisory Council has noted that a strategic Research & Technology Development (R&TD) roadmap would be very beneficial to encourage the timely availability of effective tools and methodologies to implement planetary protection requirements. New research avenues in planetary protection for ambitious future exploration missions can best be served by developing an over-arching program that integrates capability-driven developments with mission-driven implementation efforts. This paper analyzes the current status concerning microbial reduction and cleaning methods, recontamination control and bio-barriers, operational analysis methods, and addresses concepts for human exploration. Crosscutting research and support activities are discussed and a rationale for a Strategic Planetary Protection R&TD Roadmap is outlined. Such a roadmap for planetary protection provides a forum for strategic planning and will help to enable the next phases of solar system exploration.

  10. Current views on the potential for development of a HIV vaccine.

    Science.gov (United States)

    Cohen, Kristen W; Frahm, Nicole

    2017-03-01

    Despite many recent advances in the HIV prevention landscape, an effective vaccine remains the most promising tool to end the HIV-1 pandemic. Areas covered: This review summarizes past HIV vaccine efficacy trials and current vaccine strategies as well as new approaches about to move into first-in-human trials. Expert opinion: Despite many setbacks in early HIV vaccine efficacy trials, the success of RV144 has provided the glimmer of hope necessary to invigorate the vaccine field, and has led to the development of a large number of vaccine strategies aiming at inducing an array of different immune responses. The follow-up pox-protein trials, developed to replicate and enhance the polyfunctional antibody responses induced by the RV144 regimen, are already reaching efficacy trials, while a large body of work providing a more complete understanding of the development of broadly neutralizing antibodies is now being translated into immunogen design using several different strategies. T-cell based vaccines, fallen out of favor after Ad5-based trials showed increased infection rates in Ad5 seropositive vaccine recipients, are experiencing a comeback based in part on the promising results from non-human primate challenge studies using rhCMV-based immunogens. This diverse array of vaccine candidates may finally allow us to identify a broadly effective HIV vaccine able to contain the epidemic.

  11. Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments

    Directory of Open Access Journals (Sweden)

    Catherine Baugé

    2015-01-01

    Full Text Available Due to their low self-repair ability, cartilage defects that result from joint injury, aging, or osteoarthritis, are the most often irreversible and are a major cause of joint pain and chronic disability. So, in recent years, researchers and surgeons have been working hard to elaborate cartilage repair interventions for patients who suffer from cartilage damage. However, current methods do not perfectly restore hyaline cartilage and may lead to the apparition of fibro- or hypertrophic cartilage. In the next years, the development of new strategies using adult stem cells, in scaffolds, with supplementation of culture medium and/or culture in low oxygen tension should improve the quality of neoformed cartilage. Through these solutions, some of the latest technologies start to bring very promising results in repairing cartilage from traumatic injury or chondropathies. This review discusses the current knowledge about the use of adult stem cells in the context of cartilage tissue engineering and presents clinical trials in progress, as well as in the future, especially in the field of bioprinting stem cells.

  12. Life cycle greenhouse gas emissions of current oil sands technologies: GHOST model development and illustrative application.

    Science.gov (United States)

    Charpentier, Alex D; Kofoworola, Oyeshola; Bergerson, Joule A; MacLean, Heather L

    2011-11-01

    A life cycle-based model, GHOST (GreenHouse gas emissions of current Oil Sands Technologies), which quantifies emissions associated with production of diluted bitumen and synthetic crude oil (SCO) is developed. GHOST has the potential to analyze a large set of process configurations, is based on confidential oil sands project operating data, and reports ranges of resulting emissions, improvements over prior studies, which primarily included a limited set of indirect activities, utilized theoretical design data, and reported point estimates. GHOST is demonstrated through application to a major oil sands process, steam-assisted gravity drainage (SAGD). The variability in potential performance of SAGD technologies results in wide ranges of "well-to-refinery entrance gate" emissions (comprising direct and indirect emissions): 18-41 g CO(2)eq/MJ SCO, 9-18 g CO(2)eq/MJ dilbit, and 13-24 g CO(2)eq/MJ synbit. The primary contributor to SAGD's emissions is the combustion of natural gas to produce process steam, making a project's steam-to-oil ratio the most critical parameter in determining GHG performance. The demonstration (a) illustrates that a broad range of technology options, operating conditions, and resulting emissions exist among current oil sands operations, even when considering a single extraction technology, and (b) provides guidance about the feasibility of lowering SAGD project emissions.

  13. Continuing professional development and Irish hospital doctors: a survey of current use and future needs.

    Science.gov (United States)

    Maher, Bridget; Faruqui, Adnan; Horgan, Mary; Bergin, Colm; Tuathaigh, Colm O; Bennett, Deirdre

    2017-07-01

    Doctors rate clinical relevance and applicability as the most important determinants of continuing professional development (CPD) course selection. This study examined patterns of current CPD practice and perceived CPD needs among hospital doctors in Ireland across various clinical specialties. A cross-sectional survey was administered to doctors, focusing on the areas of training needs analysis, CPD course content and preferred course format. In total, 547 doctors identified doctor-patient communication as the skill ranked highest for importance and level of current performance. Workload/time organisation and stress management were areas where a skills deficiency was identified. Non-clinical CPD topics, including resilience training, management and communication skills, were preferred areas for future CPD offerings. All respondents favoured interactive, hands-on sessions. CPD course completion and preference patterns differed significantly across clinical specialties. These results highlight the importance of considering the individual needs and preferences of clinicians across clinical specialties to facilitate more effective CPD programmes. © Royal College of Physicians 2017. All rights reserved.

  14. Component development for the ITER Ion Cyclotron Heating and Current Drive Transmission Line and Matching System

    Science.gov (United States)

    Goulding, R. H.; McCarthy, M. P.; Rasmussen, D. A.; Swain, D. W.; Barber, G. C.; Barbier, C. N.; Cambell, I. H.; Gray, S. L.; Moon, R. L.; Pesavento, P. V.; Sanabria, R. M.; Fredd, E.; Greenough, N.

    2013-10-01

    The transmission line and matching network for the ITER Ion Cyclotron Heating and Current Drive System feeds two equatorial launchers, each with 24 phased current straps combined into groups of three, and each designed to couple up to 20 MW into ELMy H-mode plasmas in the frequency range 40-55 MHz, for pulse lengths up to 3600 s. The network includes > 1 km of 50 Ohm 300 mm diameter transmission line carrying up to 6 MW net power per line at VSWR = 1.5. In addition, there are 8 power splitters, 32 hybrid phase shifters incorporating 64 tuning stubs, 32 additional tuning stubs, and 36 vacuum capacitors, which are configured to provide pre-matching in the port cell region adjacent to the antenna, final matching, decoupling of mutual inductances between antenna elements, and passive ELM resilience. The development and design of the various system components will be discussed. High power tests of components have begun, and the latest results will be presented. This manuscript has been authored by UT-Battelle, LLC, under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy.

  15. Development of a universal serial bus interface circuit for ion beam current integrators.

    Science.gov (United States)

    Suresh, K; Panigrahi, B K; Nair, K G M

    2007-08-01

    A universal serial bus (USB) interface circuit has been developed to enable easy interfacing of commercial as well as custom-built ion beam current integrators to personal computer (PC) based automated experimental setups. Built using the popular PIC16F877A reduced instruction set computer and a USB-universal asynchronous receiver-transmitter/first in, first out controller, DLP2232, this USB interface circuit virtually emulates the ion beam current integrators on a host PC and uses USB 2.0 protocol to implement high speed bidirectional data transfer. Using this interface, many tedious and labor intensive ion beam irradiation and characterization experiments can be redesigned into PC based automated ones with advantages of improved accuracy, rapidity, and ease of use and control. This interface circuit was successfully used in carrying out online in situ resistivity measurement of 70 keV O(+) ion irradiated tin thin films using four probe method. In situ electrical resistance measurement showed the formation of SnO(2) phase during ion implantation.

  16. Investigation of Fiber Waviness in a Thick Glass Composite Beam Using THz NDE

    Science.gov (United States)

    Anastasi, Robert F.

    2008-01-01

    Fiber waviness in laminated composite material is introduced during manufacture because of uneven curing, resin shrinkage, or ply buckling caused by bending the composite lay-up into its final shape prior to curing. The resulting waviness has a detrimental effect on mechanical properties, therefore this condition is important to detect and characterize. Ultrasonic characterization methods are difficult to interpret because elastic wave propagation is highly dependent on ply orientation and material stresses. By comparison, the pulsed terahertz response of the composite is shown to provide clear indications of the fiber waviness. Pulsed Terahertz NDE is an electromagnetic inspection method that operates in the frequency range between 300 GHz and 3 THz. Its propagation is influenced by refractive index variations and interfaces. This work applies pulsed Terahertz NDE to the inspection of a thick composite beam with fiber waviness. The sample is a laminated glass composite material approximately 15mm thick with a 90-degree bend. Terahertz response from the planar section, away from the bend, is indicative of a homogeneous material with no major reflections from internal plies, while the multiple reflections at the bend area correspond to the fiber waviness. Results of these measurements are presented for the planar and bend areas.

  17. Infrastructure anchor bolt inspection program with NDE applications

    Science.gov (United States)

    Fish, Philip E.

    1996-11-01

    In 1990, Wisconsin Department of Transportation found a high mast light pole with two of six anchor bolts failed. This failure along with published reports from Michigan DOT about anchor bolt failures on cantilever sign structures, raised concern about the quality and condition of anchor bolts on the Wisconsin DOT system. Wisconsin Department of Transportation implemented an Anchor Bolt Inspection Program in 1990 for cantilever sign structures, high mast light towers, interstate light towers, and signal masts. The program requires an experienced inspection team and a practical inspection approach. Inspection preparation includes review of all background information such as design plans, design computations, construction plans, shop plans, and maintenance history. An inspection plan is developed. Special emphasis is placed on determining material type, cut or rolled threads, and type of coating for anchor bolts. Inspection emphasis are on "hands on" and Nondestructive evaluation. Special emphasis is placed on visual conditions of anchor bolts (cut or rolled threads, straightness, corrosion, nut tension etc.) along with ultrasonic inspection. This program places a strong emphasis on Non Destructive Testing (NDT), especially ultrasonic. Procedures and inspection calibrations are developed from similar anchor bolt geometry and material type. Cut notches are placed in the anchor bolts at locations of possible failure. NDT inspection calibrations are performed from these bolts. Report documentation includes all design plans, pictorial documentation of structural deficiencies, sketches, nondestructive evaluation reports, conclusions, and recommendations. This program has been successful in locating failed anchor bolts and critical cracks before failure of an entire structure.

  18. Current and future trends in biomarker discovery and development of companion diagnostics for arthritis.

    Science.gov (United States)

    Gibson, David S; Bustard, Michael J; McGeough, Cathy M; Murray, Helena A; Crockard, Martin A; McDowell, Andrew; Blayney, Jayne K; Gardiner, Philip V; Bjourson, Anthony J

    2015-02-01

    Musculoskeletal diseases such as rheumatoid arthritis are complex multifactorial disorders that are chronic in nature and debilitating for patients. A number of drug families are available to clinicians to manage these disorders but few tests exist to target these to the most responsive patients. As a consequence, drug failure and switching to drugs with alternate modes of action is common. In parallel, a limited number of laboratory tests are available which measure biological indicators or 'biomarkers' of disease activity, autoimmune status, or joint damage. There is a growing awareness that assimilating the fields of drug selection and diagnostic tests into 'companion diagnostics' could greatly advance disease management and improve outcomes for patients. This review aims to highlight: the current applications of biomarkers in rheumatology with particular focus on companion diagnostics; developments in the fields of proteomics, genomics, microbiomics, imaging and bioinformatics and how integration of these technologies into clinical practice could support therapeutic decisions.

  19. [Current audiovisual technologies are a constituent of the continuing professional development concept].

    Science.gov (United States)

    Bezrukova, E Iu; Zatsepa, S A

    2009-01-01

    The paper is devoted to the topical problems of using innovation, information and communication technologies (ICT) in the higher medical education system, including in postgraduate professional education. The paper shows the key principles for organizing an audiovisual technology-based educational process and gives numerous practical examples of the real use of ICT in the education of not only medical, but also other specialists and the results of studies of applying the current technical aids of innovation professional education. Since each area of manpower training has its specificity and unique goals, the authors propose the highly effective decisions to organize an educational process, which fully take into consideration of the specific features of professional education. These technologies substantially expand access to educational resources, which is of great importance for a strategy of continuing professional development.

  20. Respiratory management of motor neurone disease: a review of current practice and new developments.

    Science.gov (United States)

    Rafiq, Muhammad Khizar; Proctor, Alison Ruth; McDermott, Christopher J; Shaw, Pamela J

    2012-06-01

    Motor neurone disease is a neurodegenerative condition with a significant morbidity and shortened life expectancy. Hypoventilatory respiratory failure is the most common cause of death and respiratory function significantly predicts both survival and quality of life in patients with motor neurone disease. Accordingly, supporting and maintaining respiratory function is important in caring for these patients. The most significant advance in motor neurone disease care of recent years has been the domiciliary provision of non-invasive ventilation for treating respiratory failure. Neuromuscular respiratory weakness also leads to ineffective cough and retained airways secretions, predisposing to recurrent chest infections. In this review, we discuss current practice and recent developments in the respiratory management of motor neurone disease, in terms of ventilatory support and cough augmentation.

  1. Current views of the development of pain syndrome mechanisms in patients with osteoarthrosis. Rational pharmacotherapy

    Directory of Open Access Journals (Sweden)

    E. V. Igolkina

    2014-01-01

    Full Text Available The paper outlines the current views on mechanisms for pain development in osteoarthrosis (OA. The problem of analgesia in OA remains to be solved, which gives rise to a more careful study of the mechanisms in OA. Whether peripheral somatosensory nerve damage occurs in OA is the subject of careful investigation and dispute. The paper gives the results of studies of the neurogenic component of pain in OA patients. There is sufficient evidence for the presence of sensory anomalies accompanying pain in OA. The clinical use of questionnaires to detect neuropathic pain may assist in identifying central sensitization in patients with OA. Medicaments for the symptomatic therapy of pain are characterized.

  2. Modelling the transport system in China and evaluating the current strategies towards the sustainable transport development

    DEFF Research Database (Denmark)

    Liu, W.; Lund, H.; Mathiesen, B.V.

    2013-01-01

    in China. With this purpose in mind, a Chinese transport model has been created and three current transport strategies which are high speed railway (HSR), urban rail transit (URT) and electric vehicle (EV) were evaluated together with a reference transport system in 2020. As conservative results, 13......Transport is one of the most challenge sectors when addressing energy security and climate change due to its high reliance on oil products and lack of the alternative fuels. This paper explores the ability of three transport strategies to contribute to the development of a sustainable transport......% of the energy saving and 12% of the CO2 emission reduction can be attained by accomplishing three strategies compared with the reference transport system. However, the energy demand of transport in 2020 with the implementation of three strategies will be about 1.7 times as much as today. The three strategies...

  3. ["A medicine of human relationship" revisited--Current neurobiological and psychosomatic developments].

    Science.gov (United States)

    Beutel, Manfred I; Huber, Michael

    2007-05-01

    In his programmatic paper published 1989 in this journal, Herbert Weiner held the view that psychosomatic medicine has become a medicine of human relations. The aim of this review is to reflect if current scientific evidence supports his view. Evidence from animal studies suggests that early infant-mother separation or neglect not only has a lasting influence on attachment behaviour, but also on brain development and the ability for stress regulation mediated by environmental as well as genetic factors. Neuronal networks processing affective components of physical pain play a role in signalling painful emotional experiences due to social isolation and separation. A consistent finding across different studies is that physicians who adopt a warm, friendly and reassuring manner help activate patients endogenous opioid system, foster their compliance and promote better therapeutic results. In summary, evidence from neurobiological studies not only support Herbert Weiner's theses but also opens new venues for interdisciplinary research.

  4. Review of supercritical CO2 power cycle technology and current status of research and development

    Directory of Open Access Journals (Sweden)

    Yoonhan Ahn

    2015-10-01

    Full Text Available The supercritical CO2 (S-CO2 Brayton cycle has recently been gaining a lot of attention for application to next generation nuclear reactors. The advantages of the S-CO2 cycle are high efficiency in the mild turbine inlet temperature region and a small physical footprint with a simple layout, compact turbomachinery, and heat exchangers. Several heat sources including nuclear, fossil fuel, waste heat, and renewable heat sources such as solar thermal or fuel cells are potential application areas of the S-CO2 cycle. In this paper, the current development progress of the S-CO2 cycle is introduced. Moreover, a quick comparison of various S-CO2 layouts is presented in terms of cycle performance.

  5. From yaks to yogurt: the history, development, and current use of probiotics.

    Science.gov (United States)

    McFarland, Lynne V

    2015-05-15

    The development of probiotics, which are living bacteria or yeasts used to confer a health benefit on the host, has paralleled our research in food preservation, microbiologic identification techniques, and our understanding of how the complex interactions in microbiota impact the host's health and recovery from disease. This review briefly describes the history of probiotics, where probiotic strains were originally isolated, and the types of probiotic products currently available on the global market. In addition, the uses or indications for these probiotics are described, along with the types of clinical investigations that have been done. Continuing challenges persist for the proper probiotic strain identification, regulatory pathways, and how healthcare providers can choose a specific strain to recommend to their patients.

  6. Microwave proton source development for a high-current linac injector

    Energy Technology Data Exchange (ETDEWEB)

    Sherman, J.; Bolme, G.; Geisik, C. [Los Alamos National Lab., NM (United States). Accelerator Operations and Technology Div.] [and others

    1995-09-01

    Powerful CW proton linear accelerators (100-mA at 0.5--1.0 GeV) are being proposed for spallation neutron-source applications. A 75-keV, 110-mA dc proton injector using a microwave ion source is being tested for these applications. It has achieved 80-keV, 110-mA hydrogen-ion-beam operation. Video and dc beam-current toroid diagnostics are operational, and an EPICS control system is also operational on the 75-keV injector. A technical base development program has also been carried out on a 50-keV injector obtained from Chalk River Laboratories, and it includes low-energy beam transport studies, ion source lifetime tests, and proton-fraction enhancement studies. Technical base results and the present status of the 75-keV injector will be presented.

  7. Tritium processing for the European test blanket systems: current status of the design and development strategy

    Energy Technology Data Exchange (ETDEWEB)

    Ricapito, I.; Calderoni, P.; Poitevin, Y. [Fusion for Energy, Barcelona (Spain); Aiello, A.; Utili, M. [ENEA, Camugnano (Italy); Demange, D. [Karlsruhe Institute of Technology - KIT, Karlsruhe (Germany)

    2015-03-15

    Tritium processing technologies of the two European Test Blanket Systems (TBS), HCLL (Helium Cooled Lithium Lead) and HCPB (Helium Cooled Pebble Bed), play an essential role in meeting the main objectives of the TBS experimental campaign in ITER. The compliancy with the ITER interface requirements, in terms of space availability, service fluids, limits on tritium release, constraints on maintenance, is driving the design of the TBS tritium processing systems. Other requirements come from the characteristics of the relevant test blanket module and the scientific programme that has to be developed and implemented. This paper identifies the main requirements for the design of the TBS tritium systems and equipment and, at the same time, provides an updated overview on the current design status, mainly focusing onto the tritium extractor from Pb-16Li and TBS tritium accountancy. Considerations are also given on the possible extrapolation to DEMO breeding blanket. (authors)

  8. A Particle In Cell code development for high current ion beam transport and plasma simulations

    CERN Document Server

    Joshi, N

    2016-01-01

    A simulation package employing a Particle in Cell (PIC) method is developed to study the high current beam transport and the dynamics of plasmas. This package includes subroutines those are suited for various planned projects at University of Frankfurt. In the framework of the storage ring project (F8SR) the code was written to describe the beam optics in toroidal magnetic fields. It is used to design an injection system for a ring with closed magnetic field lines. The generalized numerical model, in Cartesian coordinates is used to describe the intense ion beam transport through the chopper system in the low energy beam section of the FRANZ project. Especially for the chopper system, the Poisson equation is implemented with irregular geometries. The Particle In Cell model is further upgraded with a Monte Carlo Collision subroutine for simulation of plasma in the volume type ion source.

  9. Inventory of managed aquifer recharge sites in Europe: historical development, current situation and perspectives

    Science.gov (United States)

    Sprenger, C.; Hartog, N.; Hernández, M.; Vilanova, E.; Grützmacher, G.; Scheibler, F.; Hannappel, S.

    2017-03-01

    Different types of managed aquifer recharge (MAR) schemes are widely distributed and applied on various scales and for various purposes in the European countries, but a systematic categorization and compilation of data has been missing up to now. The European MAR catalogue presented herein contains various key parameters collected from the available literature. The catalogue includes 224 currently active MAR sites found in 23 European countries. Large quantities of drinking water are produced by MAR sites in Hungary, Slovakia, the Netherlands, Germany, Finland, Poland, Switzerland and France. This inventory highlights that, for over a century, MAR has played an important role in the development of European water supply and contributes to drinking-water production substantially. This development has occurred autonomously, with "trial-and-error" within the full range of climatically and hydrogeologically diverse conditions of the European countries. For the future, MAR has the potential to facilitate optimal (re)use and storage of available water resources and to take advantage of the natural purification and low energy requirements during MAR operations. Particularly with respect to the re-use of wastewater treatment-plant effluent and stormwater, which is currently underdeveloped, the use of MAR can support the public acceptance of such water-resource efficient schemes. Particularly for the highly productive and urbanized coastal zones, where the pressure on freshwater supplies increases by growing water demand, salinization and increased agricultural needs for food production (such as along the Mediterranean and North Sea coasts), MAR is expected to be increasingly relied on in Europe.

  10. Inventory of managed aquifer recharge sites in Europe: historical development, current situation and perspectives

    Science.gov (United States)

    Sprenger, C.; Hartog, N.; Hernández, M.; Vilanova, E.; Grützmacher, G.; Scheibler, F.; Hannappel, S.

    2017-09-01

    Different types of managed aquifer recharge (MAR) schemes are widely distributed and applied on various scales and for various purposes in the European countries, but a systematic categorization and compilation of data has been missing up to now. The European MAR catalogue presented herein contains various key parameters collected from the available literature. The catalogue includes 224 currently active MAR sites found in 23 European countries. Large quantities of drinking water are produced by MAR sites in Hungary, Slovakia, the Netherlands, Germany, Finland, Poland, Switzerland and France. This inventory highlights that, for over a century, MAR has played an important role in the development of European water supply and contributes to drinking-water production substantially. This development has occurred autonomously, with "trial-and-error" within the full range of climatically and hydrogeologically diverse conditions of the European countries. For the future, MAR has the potential to facilitate optimal (re)use and storage of available water resources and to take advantage of the natural purification and low energy requirements during MAR operations. Particularly with respect to the re-use of wastewater treatment-plant effluent and stormwater, which is currently underdeveloped, the use of MAR can support the public acceptance of such water-resource efficient schemes. Particularly for the highly productive and urbanized coastal zones, where the pressure on freshwater supplies increases by growing water demand, salinization and increased agricultural needs for food production (such as along the Mediterranean and North Sea coasts), MAR is expected to be increasingly relied on in Europe.

  11. A survey on IVIVC/IVIVR development in the pharmaceutical industry - Past experience and current perspectives.

    Science.gov (United States)

    Nguyen, M A; Flanagan, T; Brewster, M; Kesisoglou, F; Beato, S; Biewenga, J; Crison, J; Holm, R; Li, R; Mannaert, E; McAllister, M; Mueller-Zsigmondy, M; Muenster, U; Ojala, K; Page, S; Parr, A; Rossenu, S; Timmins, P; Van Peer, A; Vermeulen, A; Langguth, P

    2017-05-01

    The present work aimed to describe the current status of IVIVC/IVIVR development in the pharmaceutical industry, focusing on the use and perception of specific approaches as well as successful and failed case studies. Two questionnaires have been distributed to 13 EFPIA partners of the Oral Biopharmaceutics Tools Initiative and to the Pharmacokinetics Working Party of the European Medicines Agency in order to capture the perspectives and experiences of industry scientists and agency members, respectively. Responses from ten companies and three European Agencies were received between May 21st 2014 and January 19th 2016. The majority of the companies acknowledged the importance of IVIVC/IVIVR throughout the drug development stages and a well-balanced rate of return on investment. However, the IVIVC/IVIVR approach seemed to be underutilized in regulatory submissions. Four of the ten companies stated to have an internal guidance related to IVIVC/IVIVR modelling, whereas three felt that an overall strategy is not necessary. Successful models mainly served to support formulation development and to provide a better mechanistic understanding. There was not yet much experience with safe-space IVIVRs as well as the use of physiologically based modelling in the field of IVIVC. At the same time, the responses from both industry and agencies indicated that there might be a need for a regulatory framework to guide the application of these novel approaches. The relevance of IVIVC/IVIVR for oral IR drug products was recognized by most of the companies. For IR formulations, relationships other than Level A correlation were more common outcomes among the provided case studies, such as multiple Level C correlation or safe-space IVIVR, which could be successfully used for requesting regulatory flexibility. Compared to the responses from industry scientists, there was a trend towards a higher appreciation of the BCS among the regulators, but a less positive attitude towards the utility

  12. Pathogenesis of metastatic disease: implications for current therapy and for the development of new therapeutic strategies.

    Science.gov (United States)

    Poste, G

    1986-01-01

    Different tumor cell subpopulations coexisting within the same tumor exhibit varied susceptibilities to antineoplastic agents. Tumor cell heterogeneity is now recognized as the principal cause of treatment failure in cancer, and is a formidable obstacle to effective therapy and to the development of drug delivery systems for selective targeting of antineoplastic agents to tumor cells. Recent insights into the genesis of tumor cell heterogeneity during progressive tumor growth reveal new complexities that raise challenging questions about the adequacy of certain approaches to the current therapy of metastatic disease and impose challenging criteria for the development of improved therapeutic strategies. Many of the experimental approaches used in the search for new antineoplastic agents and targeted drug delivery systems ignore the pathogenesis of metastasis and the problem of tumor cell heterogeneity. The adoption of more relevant assay systems is an urgent priority. These include the greater use of metastatic tumor models and the increased use of human tumor cells to replace rodent cell systems which have been of limited predictive value in identifying effective anticancer agents. In contrast to current strategies for the development of new antineoplastic drugs which seek to identify agents with activity against a broad range of histologically diverse tumors, greater success may be achieved by seeking agents active only against specific cell lineages. Many established human tumor cell lines may not be suitable for this purpose because of extensive phenotypic change produced by prolonged passage ex vivo. Development of histiotype-specific human tumor cell screens will require an extensive research effort to identify target cells that display demonstrable phenotypic relatedness to tumor cells in neoplastic lesions. Major advances in the therapy of metastatic disease are considered unlikely in the next few years, and progress will stem from improved use of existing

  13. The sustainability of current account in the presence of endogenous multiple structural breaks: Evidence from developed and developing countries

    Directory of Open Access Journals (Sweden)

    Dülger Fikret

    2016-01-01

    Full Text Available The purpose of this study is to test for the sustainability of current account in 18 developed and 10 developing countries. The stability of the relationship between export (inflows and import (outflows is assessed using the tests proposed by Mohitosh Kejriwal and Pierre Perron (2010. In particular, the nature of the long-run relationship, when multiple regime shifts are identified endogenously, is analyzed using the residual-based test of the null hypothesis of cointegration with multiple breaks proposed by Kejriwal (2008. The results clearly indicate that, for all countries, (i the stability tests reject the null of coefficient stability of the long-run relationship between exports and imports; (ii the cointegration tests that correspond to the number of breaks selected reject the null of cointegration (weak form of sustainability; and (iii the strong form of sustainability hypothesis is not supported by the data for all countries in most regimes but not for 20 of 28 countries especially in the last regime (the post-2000 era. For eight countries (Canada, New Zealand, Spain, Brazil, Mexico, South Africa, Thailand, and Turkey, the findings may be perceived as a warning to creditors and policymakers unless there are policy distortions or permanent productivity shocks to the domestic economies.

  14. Current status of solid waste management in small island developing states: A review

    Energy Technology Data Exchange (ETDEWEB)

    Mohee, Romeela [University of Mauritius, Réduit (Mauritius); Mauthoor, Sumayya, E-mail: sumayya.mauthoor@umail.uom.ac.mu [Department of Chemical & Environmental Engineering, University of Mauritius, Réduit (Mauritius); Bundhoo, Zumar M.A.; Somaroo, Geeta; Soobhany, Nuhaa; Gunasee, Sanjana [Department of Chemical & Environmental Engineering, University of Mauritius, Réduit (Mauritius)

    2015-09-15

    Highlights: • Waste management is a matter of great concern for small island developing states. • On average, waste generation rate in these islands amounts to 1.29 kg/capita/day. • Illegal dumping and landfilling prevail in most small island developing states. • Sustainable waste management practices, previously absent, are now emerging. • However, many challenges still hinder the implementation of these practices. - Abstract: This article reviews the current status of waste management in Small Island Developing States (SIDS) and the challenges that are faced in solid waste management. The waste generation rates of SIDS were compared within the three geographic regions namely Caribbean SIDS, Pacific SIDS and Atlantic, Indian Ocean, Mediterranean and South China (AIMS) SIDS and with countries of the Organisation for Economic Co-Operation and Development (OECD). Only Pacific SIDS had a waste generation rate less than 1 kg/capita/day. The waste generation rates for the three SIDS regions averaged 1.29 kg/capita/day while that for OECD countries was at a mean value of 1.35 kg/capita/day. The waste compositions in the different SIDS regions were almost similar owing to comparable consumption patterns while these differed to a large extent with wastes generated in OECD countries. In SIDS, the major fraction of MSW comprised of organics (44%) followed by recyclables namely paper, plastics, glass and metals (total: 43%). In contrast, MSW in OECD countries consisted mainly of recyclables (43%) followed by organics (37%). This article also reviewed the other functional elements of the waste management systems in SIDS. Several shortcomings were noted in the process of waste collection, transfer and transport namely the fact of having outdated collection vehicles and narrow roads which are inaccessible. Among the waste management practices in SIDS, waste disposal via landfilling, illegal dumping and backyard burning were favoured most of the time at the expense of

  15. Current development of the second generation of mTOR inhibitors as anticancer agents

    Institute of Scientific and Technical Information of China (English)

    Hong-Yu Zhou; Shi-Le Huang

    2012-01-01

    The mammalian target of rapamycin (mTOR),a serine/threonine protein kinase,acts as a “master switch” for cellular anabolic and catabolic processes,regulating the rate of cell growth and proliferation.Dysregulation of the mTOR signaling pathway occurs frequently in a variety of human tumors,and thus,mTOR has emerged as an important target for the design of anticancer agents.mTOR is found in two distinct multiprotein complexes within cells,mTORC1 and mTORC2.These two complexes consist of unique mTOR-interacting proteins and are regulated by different mechanisms.Enormous advances have been made in the development of drugs known as mTOR inhibitors.Rapamycin,the first defined inhibitor of mTOR,showed effectiveness as an anticancer agent in various preclinical models.Rapamycin analogues (rapalogs) with better pharmacologic properties have been developed.However,the clinical success of rapalogs has been limited to a few types of cancer.The discovery that mTORC2 directly phosphorylates Akt,an important survival kinase,adds new insight into the role of mTORC2 in cancer.This novel finding prompted efforts to develop the second generation of mTOR inhibitors that are able to target both mTORC1 and mTORC2.Here,we review the recent advances in the mTOR field and focus specifically on the current development of the second generation of mTOR inhibitors as anticancer agents.

  16. NDE of Space Shuttle Solid Rocket Motor field joint

    Science.gov (United States)

    Johnston, Patrick H.

    One of the most critical areas for inspection in the Space Shuttle Solid Rocket Motors is the bond between the steel case and rubber insulation in the region of the field joints. The tang-and-clevis geometry of the field joints is sufficiently complex to prohibit the use of resonance-based techniques. One approach we are investigating is to interrogate the steel-insulation bondline in the tang and clevis regions using surface-travelling waves. A low-frequency contact surface wave transmitting array transducer is under development at our laboratory for this purpose. The array is placed in acoustic contact with the steel and surface waves are launched on the inside surface or the clevis leg which propagate along the steel-insulation interface. As these surface waves propagate along the bonded surface, the magnitude of the ultrasonic energy leaking into the steel is monitored on the outer surface of the case. Our working hypothesis is that the magnitude of energy received at the outer surface of the case is dependent upon the integrity of the case-insulation bond, with less attenuation for propagation along a disbond due to imperfect acoustic coupling between the steel and rubber. Measurements on test specimens indicate a linear relationship between received signal amplitude and the length of good bend between the transmitter and receiver, suggesting the validity of this working hypothesis.

  17. Testing Current and Developing Novel Therapies for NF1-Mutant Sarcomas in a Genetically Engineered Mouse Model

    Science.gov (United States)

    2015-04-01

    1   AWARD NUMBER: W81XWH-14-1-0067 TITLE: Testing Current and Developing Novel Therapies for NF1 -Mutant Sarcomas in a Genetically Engineered...Mar 2014 - 14 Mar 2015 4. TITLE AND SUBTITLE Testing Current and Developing Novel Therapies for NF1 - Mutant Sarcomas in a Genetically Engineered...Patients with Neurofibromatosis type 1 ( NF1 ) are at increased risk for developing malignant tumors of the connective tissue called soft-tissue sarcomas

  18. A Survey on Renewable Energy Development in Malaysia: Current Status, Problems and Prospects

    Directory of Open Access Journals (Sweden)

    Alam Syed Shah

    2016-05-01

    Full Text Available Energy demand in Malaysia is increasing over seven per cent a year, while forty per cent of the energy is supplied from conventional fossil fuel. However, a number of social barriers have mired the social acceptance of renewable energy among the users. This study investigates the current status of renewable energy, problems and future outlook of renewable energy in Malaysia. A total of 200 respondents were surveyed from Klang Valley in Malaysia. Majority of the respondents use energy to generate electricity. Although some respondents reported using solar energy, there is lack of retail availability for solar energy. The findings show that limited information on renewable energy technologies, lack of awareness, and limited private sector engagement emerged as major barriers to sustainable renewable energy development. In addition, the respondents suggest for increasing policy support from the government to make information more accessible to mass users, provide economic incentives to investors and users, and promote small-community based renewable energy projects. The study suggests that the government begin small scale projects to build awareness on renewable energy, while academically, higher learning institutions include renewable energy syllabus in their academic curriculum. The study concluded that to have sustainable renewable energy development, government’s initiative, private sector engagement and users awareness must be given priority.

  19. Current status of materials development of nuclear fuel cladding tubes for light water reactors

    Energy Technology Data Exchange (ETDEWEB)

    Duan, Zhengang, E-mail: duan_zg@imr.tohoku.ac.jp [Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, Miyagi 980-8577 (Japan); Yang, Huilong [Department of Nuclear Engineering, School of Engineering, The University of Tokyo, Nakagun, Ibaraki 319-1188 (Japan); Satoh, Yuhki [Institute for Materials Research, Tohoku University, Sendai, Miyagi 980-8577 (Japan); Murakami, Kenta; Kano, Sho; Zhao, Zishou; Shen, Jingjie [Department of Nuclear Engineering, School of Engineering, The University of Tokyo, Nakagun, Ibaraki 319-1188 (Japan); Abe, Hiroaki, E-mail: abe.hiroaki@n.t.u-tokyo.ac.jp [Department of Nuclear Engineering, School of Engineering, The University of Tokyo, Nakagun, Ibaraki 319-1188 (Japan)

    2017-05-15

    Zirconium-based (Zr-based) alloys have been widely used as materials for the key components in light water reactors (LWRs), such as fuel claddings which suffer from waterside corrosion, hydrogen uptakes and strength loss at elevated temperature, especially during accident scenarios like the lost-of-coolant accident (LOCA). For the purpose of providing a safer, nuclear leakage resistant and economically viable LWRs, three general approaches have been proposed so far to develop the accident tolerant fuel (ATF) claddings: optimization of metallurgical composition and processing of Zr-based alloys, coatings on existing Zr-based alloys and replacement of current Zr-based alloys. In this manuscript, an attempt has been made to systematically present the historic development of Zr-based cladding, including the impacts of alloying elements on the material properties. Subsequently, the research investigations on coating layer on the surface of Zr-based claddings, mainly referring coating materials and fabrication methods, have been broadly reviewed. The last section of this review provides the introduction to alternative materials (Non-Zr) to Zr-based alloys for LWRs, such as advanced steels, Mo-based, and SiC-based materials.

  20. Manufacturing design and development of the current feeders and coil terminal boxes for JT-60SA

    Energy Technology Data Exchange (ETDEWEB)

    Kizu, Kaname, E-mail: kizu.kaname@jaea.go.jp [Japan Atomic Energy Agency, Naka, Ibaraki 311-0193 (Japan); Murakami, Haruyuki; Natsume, Kyohei; Tsuchiya, Katsuhiko; Koide, Yoshihiko; Yoshida, Kiyoshi [Japan Atomic Energy Agency, Naka, Ibaraki 311-0193 (Japan); Obana, Tetsuhiro; Hamaguchi, Shinji; Takahata, Kazuya [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan)

    2015-10-15

    Highlights: • Key components for current feeding system for JT-60SA were developed and tested. • The joint resistance of feeder joint sample was 1.7 nΩ at 2 T, 20 kA. • Trial manufacturing of crank shaped feeder showed the max. dimensional error of 3 mm. • Feeder insulation samples showed >60 MPa in shear strength at 77 K. - Abstract: Feeders and coil terminal boxes (CTBs) of the superconducting magnets for JT-60SA have been designed. A small tool which can connect soldering joint with vertical direction in the cryostat has been developed. The joint resistance of the sample showed 1.7 nΩ at 2 T, 4.2 K, 20 kA which is within the requirement of <5 nΩ. A prototype feeder in CTB with crank shape was manufactured. The maximum dimensional error was 3 mm being within the requirement of ±10 mm. Feeder insulation samples showed a shear strength >60 MPa which is much higher than the requirement of 10 MPa as derived from analysis. Since all the manufacturing processes concerned have been proof-tested, the production of feeders and CTBs has been released.

  1. A Survey on Renewable Energy Development in Malaysia: Current Status, Problems and Prospects

    Science.gov (United States)

    Alam, Syed Shah; Nor, Nor Fariza Mohd; Ahmad, Maisarah; Hashim, Nik Hazrul Nik

    2016-05-01

    Energy demand in Malaysia is increasing over seven per cent a year, while forty per cent of the energy is supplied from conventional fossil fuel. However, a number of social barriers have mired the social acceptance of renewable energy among the users. This study investigates the current status of renewable energy, problems and future outlook of renewable energy in Malaysia. A total of 200 respondents were surveyed from Klang Valley in Malaysia. Majority of the respondents use energy to generate electricity. Although some respondents reported using solar energy, there is lack of retail availability for solar energy. The findings show that limited information on renewable energy technologies, lack of awareness, and limited private sector engagement emerged as major barriers to sustainable renewable energy development. In addition, the respondents suggest for increasing policy support from the government to make information more accessible to mass users, provide economic incentives to investors and users, and promote small-community based renewable energy projects. The study suggests that the government begin small scale projects to build awareness on renewable energy, while academically, higher learning institutions include renewable energy syllabus in their academic curriculum. The study concluded that to have sustainable renewable energy development, government's initiative, private sector engagement and users awareness must be given priority.

  2. The current situation and development of medical device testing institutes in China.

    Science.gov (United States)

    Yang, Xiaofang; Mu, Ruihong; Fan, Yubo; Wang, Chunren; Li, Deyu

    2017-04-01

    This article analyses the current situation and development of Chinese medical device testing institutes from the perspectives of the two most important functions - testing functions and medical device standardization functions. Areas Covered: The objective of the Chinese government regulations for medical device industry is to ensure the safety and effectiveness of medical devices for Chinese patients. To support the regulation system, the Chinese government has established medical device testing institutes at different levels for example, the national, provincial, and municipal levels. These testing institutes also play an important role in technical support during medical device premarket registration and post market surveillance, they are also the vital practitioners of Chinese medical device standardization. Expert Commentary: Chinese medical device testing institutes are technical departments established by government, and serve the regulatory functions of government agency. In recent years, with the rapid development of medical device industry as well as constantly increasing international and domestic medical device market, the importance of medical device testing institute is more prominent, However, there are still some problems unsolved, such as their overall capacity remains to be improved, construction of standardization is to be strengthened, etc.

  3. A Study on the Current Status and Prospects of Development of the Tourism Services Market

    Directory of Open Access Journals (Sweden)

    Miroshnyk Mariia V.

    2017-06-01

    Full Text Available The article considers the world trends in the developmet of services market, and it has been determined that the service sector is about 70% of the world’s gross domestic product (GDP. It has been noted that the tourism sector is one of the largest in the world economy, and its market in terms of investment efficiency is among the highly profitable markets along with the gas and oil producing, industrial, and automotive markets. The tourism market in Ukraine is only about 2% of the country’s GDP, but has great potential for innovation development and tourism perspectives. Such a situation requires constant monitoring and analyzing, which makes the selected study relevant. The purpose of the article was to provide a comprehensive analysis of the current status of the market for tourism services in Ukraine and to determine the main tendencies in its further development. It has been found that the tourism industry sector in Ukraine is formed by three components: outbound (international, internal, and inbound (foreign tourism, the quantitative increase of which will increase the efficiency of the country’s tourism potential and reinforce its positive image abroad.

  4. Current research, key performances and future development of search and rescue robots

    Institute of Scientific and Technical Information of China (English)

    LIU Jinguo; WANG Yuechao; LI Bin; MA Shugen

    2007-01-01

    Frequent natural disasters and man-made catastrophes have threatened the safety of citizens and have attracted much more attention. The rescue mission under disaster environment is very complicated and dangerous for a rescue team. Search and rescue (SAR) robots can not only improve the efficiency of rescue operations but also reduce the casualty of rescuers. Robots can help rescue teams and even replace rescuers to perform dangerous missions. Search and rescue robots will play a more and more important role in the rescue operations. A survey of the research status of search and rescue robots in Japan, USA, China and other countries has been provided. According to current research,experiences and the lessons learned from applications, the five key performances of a search and rescue robot are survivability, mobility, sensing, communicability and operability.Multi-technique fusion and multi-agent intelligent network are considered to be requirements for the future development of the search and rescue robot. Disaster prevention, disaster reduction and disaster rescue are the important parts of national public safety. They are also crucial for the safety of citizens and their estates. Search and rescue robotic technique is an urgent needed, strategic and core technique for national development. It will be important and strategic for national economy and safety.

  5. A review of current strategy for rabies prevention and control in the developing world

    Directory of Open Access Journals (Sweden)

    Suneela Garg

    2017-03-01

    Full Text Available The control of Rabies, a zoonotic viral disease is a major public challenge in several developing countries. Current approaches for rabies control are overwhelmingly directed towards provision of effective post exposure prophylaxis (PEP to animal bite victims. The enormous costs involved in rabies prophylaxis is an important factor precluding its universal application in all animal bite victims especially in those residing in resource constrained settings. The intradermal route of administration has been shown to be cost effective except in peripheral regions with fewer animal bite cases. Nevertheless, rabies control program with their expected emphasis on human rabies prophylaxis have neglected canine vaccination. The feasibility of canine rabies vaccination depends primarily upon allocation of resources through political commitment and effective public private partnerships. However, in large parts of the world including India formal dog ownership constitutes a small minority of the overall canine population while state funded canine vaccination drives often fail to impress policy makers who struggle to maintain budgets for adequate coverage of rabies PEP for animal bite victims. The key to rabies control may therefore rest upon a one health approach with development of newer vaccine technology which is cost effective for vaccination in both, man and animal.

  6. Current and Future Developments in the Treatment of CD30+ Lymphomas

    Directory of Open Access Journals (Sweden)

    Lena Specht

    2015-11-01

    Full Text Available CD30 is a cell membrane protein expressed on the surface of a range of lymphomas, which has important diagnostic, pathogenic, and prognostic roles. The most common CD30+ lymphomas are Hodgkin’s lymphoma (HL and anaplastic large cell lymphoma (ALCL, but other types of lymphoma also express CD30, although less frequently. Attempts to develop a monoclonal antibody therapy that targets CD30 were initially unsuccessful, but recent Phase I and II trials have shown promising results from the use of the immune conjugate brentuximab vedotin in HL and ALCL. Phase III trials are ongoing to evaluate clearly the benefit–risk ratio when compared with standard treatment. The first of these to report preliminary findings, the AETHERA trial, showed improved progression-free survival times in relapsing/refractory HL patients treated with brentuximab vedotin as a consolidation therapy after autologous stem cell transplantation compared with those receiving placebo. Patients with rarer CD30+ lymphomas may also benefit from brentuximab vedotin therapy in the future. Moreover, combination treatment with immunomodulatory and cell cycle checkpoint modulators that are currently under development, as well as conventional chemotherapeutic agents, may yield further benefits. To this end, improved methods of CD30 detection and quantitation will improve the delineation of non-HL subtypes in which CD30-targeted therapy may be clinically indicated.

  7. Development, Testing and Installation of a Superconducting Fault Current Limiter for Medium Voltage Distribution Networks

    Science.gov (United States)

    Martini, Luciano; Bocchi, Marco; Ascade, Massimo; Valzasina, Angelo; Rossi, Valerio; Angeli, Giuliano; Ravetta, Cesare

    Since 2009 Ricerca sul Sistema Energetico (RSE S.p.A.) has been involved in the design of resistive-type Superconducting Fault Current Limiter (SFCL) for MV applications to be installed in the A2A Reti Elettriche S.p.A distribution grid in the Milano area. The project started with simulations, design and testing activities for a singlephase device; in this paper we report on the successive step, which is concerned with developing, testing and installation at the hosting utility of the final three-phase SFCL prototype. The result of this research activity is a resistive-type 9 kV/3.4 MVA SFCL device, based on first generation (1G) BSCCO tapes, developed by RSE in the framework of a R&D national project. Owing to the positive test results of partial discharge, dielectric and shortcircuit results the three-phase SFCL device is being to be installed in the A2A distribution grid in the Milano area and it is going to be soon energized starting a one-year long field-testing activity.

  8. Nuclear Technology. Course 32: Nondestructive Examination (NDE) Techniques II. Module 32-4, Operation of Magnetic Particle Test Equipment.

    Science.gov (United States)

    Groseclose, Richard

    This fourth in a series of six modules for a course titled Nondestructive Examination (NDE) Techniques II describes the specific technique variables and options which are available to the test technician, provides instructions for selecting and operating the appropriate test equipment, describes physical criteria for detectable discontinuities,…

  9. Nuclear Technology. Course 32: Nondestructive Examination (NDE) II. Module 32-3, Fundamentals of Magnetic Particle Testing.

    Science.gov (United States)

    Groseclose, Richard

    This third in a series of six modules for a course titled Nondestructive Examination (NDE) Techniques II explains the principles of magnets and magnetic fields and how they are applied in magnetic particle testing, describes the theory and methods of magnetizing test specimens, describes the test equipment used, discusses the principles and…

  10. Peatused teekonnal läände : [luuletused] / James Wright ; tõlk. Jüri Talvet

    Index Scriptorium Estoniae

    Wright, James

    2008-01-01

    Sisu: Peatused teekonnal läände ; Kaks kassiahastust ; Kaubamaja kassa juures ; Vastuseks kuuldusele et vanim lõbumaja Wheelingis, Lääne-Virginias, on kinni pandud ; Hiline november põllul ; Sappho järgi mugandatud moraaliluuletus ; Sajandi ood ; Jah, aga. Elu- ja loomeloolisi andmeid autori kohta lk. 535

  11. Peatused teekonnal läände : [luuletused] / James Wright ; tõlk. Jüri Talvet

    Index Scriptorium Estoniae

    Wright, James

    2008-01-01

    Sisu: Peatused teekonnal läände ; Kaks kassiahastust ; Kaubamaja kassa juures ; Vastuseks kuuldusele et vanim lõbumaja Wheelingis, Lääne-Virginias, on kinni pandud ; Hiline november põllul ; Sappho järgi mugandatud moraaliluuletus ; Sajandi ood ; Jah, aga. Elu- ja loomeloolisi andmeid autori kohta lk. 535

  12. Current Status of Bruton's Tyrosine Kinase Inhibitor Development and Use in B-Cell Malignancies.

    Science.gov (United States)

    Aw, Andrew; Brown, Jennifer R

    2017-07-01

    The B-cell receptor (BCR) pathway plays an important role in the survival, proliferation and trafficking of cancer cells in a variety of B-cell malignancies. Recently, a number of agents have been developed to target various components of the BCR pathway. One such target is Bruton's tyrosine kinase (BTK), a Tec family kinase member found near the cell membrane that is involved in upstream BCR signaling. The biological function of BTK in several B-cell lymphoid malignancies has led to the development of the oral BTK inhibitor ibrutinib. In chronic lymphocytic leukemia (CLL), ibrutinib has demonstrated durable clinical responses in relapsed/refractory (R/R) patients, including those with the high-risk del(17p) cytogenetic abnormality. These findings have paved the way for trials evaluating ibrutinib in previously untreated CLL patients, and also in combination with chemoimmunotherapy or other novel agents. Durable clinical responses have also been demonstrated in mantle cell lymphoma (MCL) and Waldenström's macroglobulinemia (WM) patients treated with ibrutinib. Ibrutinib is generally well tolerated, although current follow-up remains short and patients of advanced age are more likely to discontinue treatment for toxicity. Treatment-specific side effects such as bleeding and atrial fibrillation may, at least partly, be related to off-target inhibition of non-BTK kinases. Studies evaluating other potential indications for BTK inhibition are ongoing, including in post-allogeneic hematopoietic stem cell transplant patients for whom ibrutinib may be effective in modulating graft-versus-host disease. Combination trials of ibrutinib with venetoclax, a Bcl-2 inhibitor, are underway and are supported by sound preclinical rationale. Several next-generation BTK inhibitors are under development with the goal of decreasing treatment-related toxicity and resistance.

  13. [Requirements for quality indicators. The relevance of current developments in outcomes research for quality management].

    Science.gov (United States)

    Schmitt, Jochen; Petzold, Thomas; Eberlein-Gonska, Maria; Neugebauer, Edmund A M

    2013-01-01

    The assessment of the health state in patients and changes in their health state for the purpose of diagnosis, prognosis and monitoring of treatment response plays a central role in clinical practice. Quality criteria for measurements in medicine include validity, reliability, responsiveness, interpretability, and feasibility. High-quality measurement instruments are a prerequisite for evidence-based medicine. Therefore, international outcomes research groups have developed methods for quality assurance and for the standardisation of measurement instruments. Quality indicators are instruments to measure the quality of care. Due to the increasing relevance of quality assessment for all stakeholders in healthcare and due to the political intention to draw relevant conclusions from the assessment of the quality of care, quality indicators must at least meet the same high standards that are required for clinical trial end points. However, independent researchers and clinicians do not engage in the validation and standardisation of quality indicators in Germany; currently, only the AQUA institute (as assigned by the German GBA) deals with this important issue. Current activities concerning the validation of quality indicators do not meet the requirements of evidence-based healthcare. This is a critical barrier to achieving the political goals of quality medicine. Therefore, the authors propose a multi-step, multi-professional, evidence-driven and evidence-generating consensus process on the basis of established methods of outcomes research for the advancement of quality assessment with quality indicators in Germany. All relevant stakeholders should participate in this process. Copyright © 2013. Published by Elsevier GmbH.

  14. Development of a high-current hydrogen-negative ion source for LHD-NBI system

    Energy Technology Data Exchange (ETDEWEB)

    Takeiri, Yasuhiko; Osakabe, Masaki; Tsumori, Katsuyoshi; Oka, Yoshihide; Kaneko, Osamu; Asano, Eiji; Kawamoto, Toshikazu; Akiyama, Ryuichi [National Inst. for Fusion Science, Toki, Gifu (Japan); Tanaka, Masanobu

    1998-08-01

    We have developed a high-current hydrogen-negative ion source for a negative-ion-based NBI system in Large Helical Device (LHD). The ion source is a cesium-seeded volume-production source equipped with an external magnetic filter. An arc chamber is rectangular, the dimensions of which are 35 cm x 145 cm in cross section and 21 cm in depth. A three-grid single-stage accelerator is divided into five sections longitudinally, each of which has 154(14 x 11) apertures in an area of 25 cm x 25 cm. The ion source was tested in the negative-NBI teststand, and 25 A of the negative ion beam is incident on a beamdump 13 m downstream with an energy of 104 keV for 1 sec. Multibeamlets of 770 are focused on a focal point 13 m downstream with an averaged divergence angle of 10 mrad by the geometrical arrangement of five sections of grid and the aperture displacement technique of the grounded grid. A uniform beam in the vertical direction over 125 cm is obtained with uniform plasma production in the arc chamber by balancing individual arc currents flowing through each filament. Long-pulse beam production was performed, and 1.3 MW of the negative ion beam is incident on the beamdump for 10 sec, and the temperature rise of the cooling water is almost saturated for the extraction and the grounded grids. These results satisfy the first-step specification of the LHD-NBI system. (author)

  15. Labour Markets Trends, Financial Globalization and the current crisis in Developing Countries

    NARCIS (Netherlands)

    R.E. van der Hoeven (Rolph)

    2010-01-01

    textabstractThe current wave of globalization has profound labour market effects, accentuated, in many cases, by the current financial and economic crisis. This paper reviews general labour market trends and country examples, arguing that the current globalization process makes labour’s position mor

  16. Labour Markets Trends, Financial Globalization and the current crisis in Developing Countries

    NARCIS (Netherlands)

    R.E. van der Hoeven (Rolph)

    2010-01-01

    textabstractThe current wave of globalization has profound labour market effects, accentuated, in many cases, by the current financial and economic crisis. This paper reviews general labour market trends and country examples, arguing that the current globalization process makes labour’s position

  17. THE PECULIARITIES OF THE U. S. HIGHER EDUCATION DEVELOPMENT STRATEGY IN THE CONTEXT OF CURRENT CONDITIONS

    Directory of Open Access Journals (Sweden)

    Olga I. Fomina

    2014-01-01

    Full Text Available Abstract. The aim of the research is to investigate a current state of the US higher education and to show obstacles in a way of its innovative perfection; to reveal specificity of the US state policy concerning the higher school; to define factors that influence the effectiveness of the American research universities during the last decades. Methods. The author applies for methods of the retrospective and logic analysis while considering social and economic conditions and features of functioning of the American higher educational institutions during the latter half of 20th – the early 21st centuries. Conclusions on a condition and prospects of development of the US higher education are made on the basis of the review and the author’s interpretation of original documentary sources tenor and the official statistical data. Results. The author specifies the groups of factors that provide functioning efficiency of leading research universities of the USA. The research findings demonstrate that the diversification of funding sources, the concentration of talents in professorial, scientific, student communities, the guarantee of the academic mobility, and the favorable management structure of the US universities allow to lower dependence on economic instability, to provide development dynamism and adequately react to present calls. The characteristic of the system developed in the present period of the US higher education is given; the directions of its innovative development in modern conditions are defined. Scientific novelty. The author singles out and proves the problems of the US higher school caused by an economic crisis in the early 21st century and essentially affected the state strategy in educational management sphere and the corporate policy of high schools, taking into consideration the inescapable fact that features of the US higher education system are caused by aspiration of this state to hold the leading positions in the world

  18. The Impact of Current Developments in Post-Compulsory Education on Young People with Learning Difficulties and/or Disabilities.

    Science.gov (United States)

    Cooper, Deborah

    1999-01-01

    This article considers ways in which opportunities for children with special educational needs in England and Wales are being affected by current developments in post-compulsory education. The development of a Lifelong Learning Partnership by the Milton Keynes Council is used to illustrate how major developments affect local authorities.…

  19. Development and application of freshwater sediment-toxicity benchmarks for currently used pesticides.

    Science.gov (United States)

    Nowell, Lisa H; Norman, Julia E; Ingersoll, Christopher G; Moran, Patrick W

    2016-04-15

    Sediment-toxicity benchmarks are needed to interpret the biological significance of currently used pesticides detected in whole sediments. Two types of freshwater sediment benchmarks for pesticides were developed using spiked-sediment bioassay (SSB) data from the literature. These benchmarks can be used to interpret sediment-toxicity data or to assess the potential toxicity of pesticides in whole sediment. The Likely Effect Benchmark (LEB) defines a pesticide concentration in whole sediment above which there is a high probability of adverse effects on benthic invertebrates, and the Threshold Effect Benchmark (TEB) defines a concentration below which adverse effects are unlikely. For compounds without available SSBs, benchmarks were estimated using equilibrium partitioning (EqP). When a sediment sample contains a pesticide mixture, benchmark quotients can be summed for all detected pesticides to produce an indicator of potential toxicity for that mixture. Benchmarks were developed for 48 pesticide compounds using SSB data and 81 compounds using the EqP approach. In an example application, data for pesticides measured in sediment from 197 streams across the United States were evaluated using these benchmarks, and compared to measured toxicity from whole-sediment toxicity tests conducted with the amphipod Hyalella azteca (28-d exposures) and the midge Chironomus dilutus (10-d exposures). Amphipod survival, weight, and biomass were significantly and inversely related to summed benchmark quotients, whereas midge survival, weight, and biomass showed no relationship to benchmarks. Samples with LEB exceedances were rare (n=3), but all were toxic to amphipods (i.e., significantly different from control). Significant toxicity to amphipods was observed for 72% of samples exceeding one or more TEBs, compared to 18% of samples below all TEBs. Factors affecting toxicity below TEBs may include the presence of contaminants other than pesticides, physical/chemical characteristics

  20. The Current Condition and Possibilities of Development of Festival Tourism in the Lublin Region

    Directory of Open Access Journals (Sweden)

    Pioš Katarzyna

    2014-07-01

    Full Text Available Introduction. The number, range, and diversity of events with a character of festivals have been growing in the Lublin Region over the last several years. The events are organised by various entities and institutions. Information about them is largely dispersed. No study has been conducted so far determining the spatial distribution of festivals at the regional scale, and analysing their offer in the context of possibilities of development of festival tourism. Therefore, a study in the scope was undertaken with consideration of the cultural conditionings of some of the events. Material and methods. In periods from July to December 2010 and from September to December 2013, secondary information was analysed (statistics, records, and scientific studies, and original material was collected (field inventory, interview, and diagnostic survey regarding the current condition of festival tourism in the Lublin Region. Results. The collected data on festival tourism offers suggest that the number of festivals in the Lublin Region has been continuously increasing from year to year. According to the obtained data, festivals with a duration of 3 and 5 days are dominant. The majority of festivals are held in summer months, usually on weekends. Music and interdisciplinary festivals with international, national, and regional range are prevalent. Some of them already have a history of 47 years. The analysis of the spatial distribution of the festivals subject to the inventory suggests that the majority of them are organised in the largest cities of the region, namely Lublin, Zamośæ, and Kazimierz Dolny. Conclusions. Due to the very diverse offer of festivals, and the manner of their promotion, they play an important role in the promotion of the Lublin Region. The offer, spatial distribution, and dynamics in the scope of organisation of festivals provide good perspectives for the development of festival tourism in the Lublin Region.