WorldWideScience

Sample records for current knowledge related

  1. Current knowledge and trends in age-related macular degeneration: today's and future treatments.

    Science.gov (United States)

    Velez-Montoya, Raul; Oliver, Scott C N; Olson, Jeffrey L; Fine, Stuart L; Mandava, Naresh; Quiroz-Mercado, Hugo

    2013-09-01

    To address the most dynamic and current issues concerning today's treatment options and promising research efforts regarding treatment for age-related macular degeneration. This review is aimed to serve as a practical reference for more in-depth reviews on the subject. An online review of the database PubMed and Ovid were performed, searching for the key words age-related macular degeneration, AMD, VEGF, treatment, PDT, steroids, bevacizumab, ranibizumab, VEGF-trap, radiation, combined therapy, as well as their compound phrases. The search was limited to articles published since 1985. All returned articles were carefully screened, and their references were manually reviewed for additional relevant data. The web page www.clinicaltrials.gov was also accessed in search of relevant research trials. A total of 363 articles were reviewed, including 64 additional articles extracted from the references. At the end, only 160 references were included in this review. Treatment for age-related macular degeneration is a very dynamic research field. While current treatments are mainly aimed at blocking vascular endothelial growth factor, future treatments seek to prevent vision loss because of scarring. Promising efforts have been made to address the dry form of the disease, which has lacked effective treatment.

  2. Panel: Current Status of Knowledge and Recommendations for Further Related Activities

    International Nuclear Information System (INIS)

    Caldarola, L.; Costa, J.; Fauske, Hans K.; Jakeman, D.; Mizuta, H.; Wright, R.W.; Stadie, K.B.

    1976-01-01

    This Panel consists of two parts, in the first part the participants attempt to summarise their views on the current status and knowledge of SFI and its importance for the LMFBR safety case and in the second part they try to agree on recommendations for future actions. The first question tackled was: what progress has been made since the Ispra meeting which was a little over two years ago - in answering the question: 'what role does SFI play in LMFBR safety'? The second question approached was: 'Is it possible to identify SFI areas which are not yet covered by the present research and development programme? Finally 4 recommendations were proposed: 1. to have another meeting of the same nature as this one and the previous ones in two years' time; 2. to create a group dealing with the fundamental science with a view to further the safety of the LMFBR. This group would meet more regularly and would not require, and that is the important thing, approval from-CSNI every time it meets; 3. to discontinue the group on calculational models; 4. to publish at least one to two newsletters between this SFI meeting and the next SFI meeting in two years

  3. Black guillemot ecology in relation to tidal stream energy generation: An evaluation of current knowledge and information gaps.

    Science.gov (United States)

    Johnston, Daniel T; Furness, Robert W; Robbins, Alexandra M C; Tyler, Glen; Taggart, Mark A; Masden, Elizabeth A

    2018-03-01

    The black guillemot Cepphus grylle has been identified as a species likely to interact with marine renewable energy devices, specifically tidal turbines, with the potential to experience negative impacts. This likelihood is primarily based on the species being a diving seabird, and an inshore, benthic forager often associating with tidal streams. These behavioural properties may bring them into contact with turbine blades, or make them susceptible to alterations to tidal current speed, and/or changes in benthic habitat structure. We examine the knowledge currently available to assess the potential impacts of tidal stream turbines on black guillemot ecology, highlight knowledge gaps and make recommendations for future research. The key ecological aspects investigated include: foraging movements, diving behaviour, seasonal distribution, other sources of disturbance and colony recovery. Relating to foraging behaviour, between studies there is heterogeneity in black guillemot habitat use in relation to season, tide, diurnal cycles, and bathymetry. Currently, there is also little knowledge regarding the benthic habitats associated with foraging. With respect to diving behaviour, there is currently no available research regarding how black guillemots orientate and manoeuvre within the water column. Black guillemots are considered to be a non-migratory species, however little is known about their winter foraging range and habitat. The effect of human disturbance on breeding habitat and the metapopulation responses to potential mortalities are unknown. It is clear further understanding of black guillemot foraging habitat and behaviour is needed to provide renewable energy developers with the knowledge to sustainably locate tidal turbines and mitigate their impacts. Copyright © 2018 Elsevier Ltd. All rights reserved.

  4. Current Knowledge of Leishmania Vectors in Mexico: How Geographic Distributions of Species Relate to Transmission Areas

    Science.gov (United States)

    González, Camila; Rebollar-Téllez, Eduardo A.; Ibáñez-Bernal, Sergio; Becker-Fauser, Ingeborg; Martínez-Meyer, Enrique; Peterson, A. Townsend; Sánchez-Cordero, Víctor

    2011-01-01

    Leishmaniases are a group of vector-borne diseases with different clinical manifestations caused by parasites transmitted by sand fly vectors. In Mexico, the sand fly Lutzomyia olmeca olmeca is the only vector proven to transmit the parasite Leishmania mexicana to humans, which causes leishmaniasis. Other vector species with potential medical importance have been obtained, but their geographic distributions and relation to transmission areas have never been assessed. We modeled the ecological niches of nine sand fly species and projected niches to estimate potential distributions by using known occurrences, environmental coverages, and the algorithms GARP and Maxent. All vector species were distributed in areas with known recurrent transmission, except for Lu. diabolica, which appeared to be related only to areas of occasional transmission in northern Mexico. The distribution of Lu. o. olmeca does not overlap with all reported cutaneous leishmaniasis cases, suggesting that Lu. cruciata and Lu. shannoni are likely also involved as primary vectors in those areas. Our study provides useful information of potential risk areas of leishmaniasis transmission in Mexico. PMID:22049037

  5. CURRENT TRENDS IN THE KNOWLEDGE ECONOMY

    Directory of Open Access Journals (Sweden)

    Ciprian Ionel HRETCANU

    2015-07-01

    Full Text Available In this paper we discuss various aspects of the current economy known as the knowledge economy. Also we will review two indicators of this new economy, because these indicators presents a general plan on access, use and degree of diffusion of knowledge. Then, based on these indicators and taking into account other aspects, we outline the structure relations between "new economy" and "digital economy". Finally we present the main types of business existing in the digital economy.

  6. Current knowledge on pancreatic cancer

    Directory of Open Access Journals (Sweden)

    Juan eIovanna

    2012-01-01

    Full Text Available Pancreatic cancer is the fourth leading cause of cancer death with a median survival of 6 months and a dismal 5-year survival rate of 3-5%. The development and progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes and the deregulation of many signalling pathways. Therefore, the strategies targeting these molecules as well as their downstream signalling could be promising for the prevention and treatment of pancreatic cancer. However, although targeted therapies for pancreatic cancer have yielded encouraging results in vitro and in animal models, these findings have not been translated into improved outcomes in clinical trials. This failure is due to an incomplete understanding of the biology of pancreatic cancer and to the selection of poorly efficient or imperfectly targeted agents. In this review, we will critically present the current knowledge regarding the molecular, biochemical, clinical and therapeutic aspects of pancreatic cancer.

  7. Current Knowledge on Pancreatic Cancer

    International Nuclear Information System (INIS)

    Iovanna, Juan; Mallmann, Maria Cecilia; Gonçalves, Anthony; Turrini, Olivier; Dagorn, Jean-Charles

    2012-01-01

    Pancreatic cancer is the fourth leading cause of cancer death with a median survival of 6 months and a dismal 5-year survival rate of 3–5%. The development and progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes, and the deregulation of many signaling pathways. Therefore, the strategies targeting these molecules as well as their downstream signaling could be promising for the prevention and treatment of pancreatic cancer. However, although targeted therapies for pancreatic cancer have yielded encouraging results in vitro and in animal models, these findings have not been translated into improved outcomes in clinical trials. This failure is due to an incomplete understanding of the biology of pancreatic cancer and to the selection of poorly efficient or imperfectly targeted agents. In this review, we will critically present the current knowledge regarding the molecular, biochemical, clinical, and therapeutic aspects of pancreatic cancer.

  8. Current Knowledge on Pancreatic Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Iovanna, Juan [INSERM U624, Stress Cellulaire, Parc Scientifique et Technologique de Luminy, Marseille (France); Mallmann, Maria Cecilia [Centre d’Investigation Clinique de Marseille, Marseille (France); Gonçalves, Anthony [Département d’Oncologie Médicale, Institut Paoli-Calmettes, Marseille (France); Turrini, Olivier [Département de Chirurgie Oncologique, Institut Paoli-Calmettes, Marseille (France); Dagorn, Jean-Charles, E-mail: juan.iovanna@inserm.fr [INSERM U624, Stress Cellulaire, Parc Scientifique et Technologique de Luminy, Marseille (France)

    2012-01-31

    Pancreatic cancer is the fourth leading cause of cancer death with a median survival of 6 months and a dismal 5-year survival rate of 3–5%. The development and progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes, and the deregulation of many signaling pathways. Therefore, the strategies targeting these molecules as well as their downstream signaling could be promising for the prevention and treatment of pancreatic cancer. However, although targeted therapies for pancreatic cancer have yielded encouraging results in vitro and in animal models, these findings have not been translated into improved outcomes in clinical trials. This failure is due to an incomplete understanding of the biology of pancreatic cancer and to the selection of poorly efficient or imperfectly targeted agents. In this review, we will critically present the current knowledge regarding the molecular, biochemical, clinical, and therapeutic aspects of pancreatic cancer.

  9. Current Knowledge on Listeria monocytogenes Biofilms in Food-Related Environments: Incidence, Resistance to Biocides, Ecology and Biocontrol

    Directory of Open Access Journals (Sweden)

    Pedro Rodríguez-López

    2018-06-01

    Full Text Available Although many efforts have been made to control Listeria monocytogenes in the food industry, growing pervasiveness amongst the population over the last decades has made this bacterium considered to be one of the most hazardous foodborne pathogens. Its outstanding biocide tolerance capacity and ability to promiscuously associate with other bacterial species forming multispecies communities have permitted this microorganism to survive and persist within the industrial environment. This review is designed to give the reader an overall picture of the current state-of-the-art in L. monocytogenes sessile communities in terms of food safety and legislation, ecological aspects and biocontrol strategies.

  10. Dietary Magnesium and Genetic Interactions in Diabetes and Related Risk Factors: A Brief Overview of Current Knowledge

    Science.gov (United States)

    Hruby, Adela; McKeown, Nicola M.; Song, Yiqing; Djoussé, Luc

    2013-01-01

    Nutritional genomics has exploded in the last decade, yielding insights—both nutrigenomic and nutrigenetic—into the physiology of dietary interactions and our genes. Among these are insights into the regulation of magnesium transport and homeostasis and mechanisms underlying magnesium’s role in insulin and glucose handling. Recent observational evidence has attempted to examine some promising research avenues on interaction between genetics and dietary magnesium in relation to diabetes and diabetes risk factors. This brief review summarizes the recent evidence on dietary magnesium’s role in diabetes and related traits in the presence of underlying genetic risk, and discusses future potential research directions. PMID:24322525

  11. Arsenic in Groundwater: A Review of Current Knowledge and Relation to the CALFED Solution Area with Recommendations for Needed Research

    Directory of Open Access Journals (Sweden)

    Alan H. Welch

    2006-09-01

    Full Text Available Ground water with arsenic concentrations greater than the U.S. Environmental Protection Agency drinking water standard exists throughout much of the CALFED solution area. These high concentrations are of con-cern from the standpoint of both existing water supply and development of conjunctive use projects. Much is known about arsenic mobility in ground water subject to different hydrologic and geochemical conditions. However, some important knowledge gaps exist that limit the ability to design water supply projects that could prevent arsenic mobilization or promote arsenic removal from ground water. A few well studied sys-tems could provide a much better understanding of methods for preventing or eliminating high arsenic problems. Within the context of the examination of a few detailed field studies, some important research needs include: 1. Determining the significance of metal-bridging aqueous complexes involving inorgan-ic arsenic and natural organic matter, 2. In the con-text of in situ remediation, determining whether of metal oxides. Little is known about the quantitative significance competition of inorganic arsenic with other inorganic aqueous species in natu-ral systems. Experiments should be conducted with actual aquifer materials, as the effects of aging on arsenic desorption in laboratory studies are quite sig-nificant. 3. Devise methods to detect and quantify rates of oxidation/reduction reactions of arsenic that are carried out by microorganisms at ambient concen-trations of arsenic and under in situ conditions. The findings from detailed field studies have the potential for greatly reducing the cost of meeting the new drinking-water standard for arsenic. The research would benefit a broad constituency.

  12. Current Knowledge on Hepatitis E.

    Science.gov (United States)

    Pérez-Gracia, María Teresa; García, Mario; Suay, Beatriz; Mateos-Lindemann, María Luisa

    2015-06-28

    Although only a single serotype of hepatitis E virus (HEV), the causative agent of hepatitis E, has been identified, there is great genetic variation among the different HEV isolates reported. There are at least four major recognized genotypes of HEV: genotypes 1 and 2 are mainly restricted to humans and linked to epidemic outbreaks in nonindustrialized countries, whereas genotypes 3 and 4 are zoonotic in both developing and industrialized countries. Besides human strains, genotype 3 and 4 strains of HEV have been genetically characterized from swine, sika deer, mongooses, sheep, and rabbits. Currently, there are approximately 11,000 human and animal sequences of HEV available at the International Nucleotide Sequence Database Collaboration. HEV is the major cause of waterborne outbreaks of hepatitis in areas of poor sanitation. Additionally, it is responsible for sporadic cases of viral hepatitis in not only endemic but industrialized countries as well. Transmission of HEV occurs predominantly by the fecal-oral route, although parenteral and perinatal routes have been reported. HEV infection develops in most individuals as a self-limiting, acute, icteric hepatitis; with mortality rates around 1%. However, some affected individuals will develop fulminant hepatic failure, a serious condition that is frequently fatal without a liver transplant. This complication is particularly common when the infection occurs in pregnant women, where mortality rates rise dramatically to up to 25%. Among the preventive measures available to avoid HEV infection, two separate subunit vaccines containing recombinant truncated capsid proteins of HEV have been shown to be highly effective in the prevention of disease. One of them, HEV 239, was approved in China, and its commercialization by Innovax began in November 2012 under the name Hecolin(®).

  13. Current Knowledge on Microarray Technology - An Overview

    African Journals Online (AJOL)

    Erah

    Review Article. Current Knowledge ... containing libraries of oligonucleotides robotically ... measurements, and averages over each oligonucleotide. ... quality of chips produced depends critically ..... Bae EK, Lee H, Lee JS, Noh EW. Isolation ...

  14. Fluctuation Relations for Currents

    Science.gov (United States)

    Sinitsyn, Nikolai; Akimov, Alexei; Chernyak, Vladimir; Chertkov, Michael

    2011-03-01

    We consider a non-equilibrium statistical system on a graph or a network. Identical particles are injected, interact with each other, traverse, and leave the graph in a stochastic manner described in terms of Poisson rates, possibly strongly dependent on time and instantaneous occupation numbers at the nodes of the graph. We show that the system demonstrates a profound statistical symmetry, leading to new Fluctuation Relations that originate from the supersymmetry and the principle of the geometric universality of currents rather than from the relations between probabilities of forward and reverse trajectories. NSF/ECCS-0925618, NSF/CHE-0808910 and DOE at LANL under Contract No. DE-AC52-06NA25396.

  15. Current Hitachi knowledge engineering systems: an overview

    Energy Technology Data Exchange (ETDEWEB)

    Masui, S; Maeda, A; Masuishi, T [Hitachi, Ltd., Tokyo (Japan)

    1992-02-01

    In order to bring the knowledge engineering technology up to the practical phase, Hitachi has provided several knowledge engineering system products, including expert system building tools, knowledge acquisition tools, and many kinds of stand-alone and build-in expert systems in both the business and process control fields. In this review article, an overview of Hitachi{prime}s recent knowledge systems is described, which includes a trend analysis on recent market recognition. In addition, to introduce the Hitachi{prime}s current activities, a new product, a user interface building tool, and a new method of tuning fuzzy membership functions using a neuro-computing algorithm are also described. Furthermore, it is pointed out that not only practical tools and methodologies, but also a practical development team, including a planning section, a cooperating expert, a user section, and experienced knowledge engineers, is needed to achieve practical expert systems. 20 refs., 10 figs., 1 tab.

  16. Loyalty Programmes : Current Knowledge and Research Directions

    NARCIS (Netherlands)

    Dorotic, Matilda; Bijmolt, Tammo H. A.; Verhoef, Peter C.

    Loyalty programmes (LPs) have increased in number and popularity, but their effects on customer behaviour remain equivocal, due to a lack of understanding of the drivers of LP effectiveness and insufficient generalizable conclusions across prior studies. This paper synthesizes current knowledge

  17. Knowledge Repository for Fmea Related Knowledge

    Science.gov (United States)

    Cândea, Gabriela Simona; Kifor, Claudiu Vasile; Cândea, Ciprian

    2014-11-01

    This paper presents innovative usage of knowledge system into Failure Mode and Effects Analysis (FMEA) process using the ontology to represent the knowledge. Knowledge system is built to serve multi-projects work that nowadays are in place in any manufacturing or services provider, and knowledge must be retained and reused at the company level and not only at project level. The system is following the FMEA methodology and the validation of the concept is compliant with the automotive industry standards published by Automotive Industry Action Group, and not only. Collaboration is assured trough web-based GUI that supports multiple users access at any time

  18. [Male contraception - the current state of knowledge].

    Science.gov (United States)

    Zdrojewicz, Zygmynt; Kasperska, Karolina; Lewandowska, Marta

    2016-08-01

    Contraception is important from a health, psychological and socioeconomic point of view. Due to the fact that male-based contraceptive methods are mostly represented by condoms and vasectomy, researchers are working on the new solutions, which could let the men be more involved in a conscious family planning. In this review we will present the current state of knowledge on this subject. There is a lot going on in the field of hormonal contraception. Studies including testosterone, progestins, synthetic androgens and other derivatives are on a different stages of clinical trials and mostly demonstrate high efficacy rates. Recent discovers of Izumo and Juno proteins, essential for the fertilization process, give hope for an easily reversible, non-hormonal method. Researchers are also trying to interfere with the process of spermatogenesis using BRDT inhibitor - JQ1, or neutralize the sperm by injecting styrene maleic anhydride (SMA) into the lumen of the vas deferens. The other studies explore processes involved in proper sperm motility. A vaccine which induces an immune response to the reproductive system is also an interesting method. The latest research use ultrasound waves and mechanical device which blocks the patency of vas deferens. The aim of the study current state of knowledge male contraception. © 2016 MEDPRESS.

  19. [Hypnosis and pain: current and perspective knowledge].

    Science.gov (United States)

    Bioy, Antoine

    2012-06-27

    After further controversies, the definition of hypnosis is to be at the same time a modified state of consciousness and a particular intersubjective relation between a practitioner and his patient. In a synthetic way, we can say that mechanisms of hypnosis on acute pain are now well known, and its efficiency is particularly proved in the pain provoked by the care. On the other hand, the knowledge concerning the action of the hypnosis on chronic pain is much more complex to understand. If the hypnosis allows connoting differently pain and to decrease its implication in patient's life, otherWise the long-term reorganizations of hypnosis on chronic pain are still for the study. In practice, the field which his particularly in development is the analogical processes of the speech, because they are particularly present in pain medicine, and easy to use in hypnotic method.

  20. Associating current knowledge with that of past experience based on knowledge about automata

    Energy Technology Data Exchange (ETDEWEB)

    Koenig, E C

    1982-01-01

    Important to the performance of interactive systems is the ability of its members to associate current knowledge with knowledge of past experience. Knowledge association results in greater detail of a current knowledge and is demonstrated through the use of examples. It is based on knowledge about automata and the knowledge structures are in the form of graphs. 11 references.

  1. Bioherbicides: Current knowledge on weed control mechanism.

    Science.gov (United States)

    Radhakrishnan, Ramalingam; Alqarawi, Abdulaziz A; Abd Allah, Elsayed Fathi

    2018-04-17

    Weed control is a challenging event during crop cultivation. Integrated management, including the application of bioherbicides, is an emerging method for weed control in sustainable agriculture. Plant extracts, allelochemicals and some microbes are utilized as bioherbicides to control weed populations. Bioherbicides based on plants and microbes inhibit the germination and growth of weeds; however,few studies conducted in weed physiology. This review ascribes the current knowledge of the physiological changes in weeds that occur during the exposure to bioherbicides. Plant extracts or metabolites are absorbed by weed seeds, which initiates damage to the cell membrane, DNA, mitosis, amylase activity and other biochemical processes and delays or inhibits seed germination. The growth of weeds is also retarded due to low rates of root-cell division, nutrient uptake, photosynthetic pigment synthesis, and plant growth hormone synthesis, while the productions of reactive oxygen species (ROS) and stress-mediated hormones increase, including irregular antioxidant activity. However, lytic enzymes and toxic substances secreted from microbes degrade the weed seed coat and utilize the endosperm for survival, which inhibits seed germination. The microbes grow through the intercellular spaces to reach the root core, and the deposition of toxins in the cells affects cell division and cellular functions. Some of the metabolites of deleterious microbes cause disease, necrosis and chlorosis,which inhibit the germination and growth of weed seeds by suppressing photosynthesis and gibberellin activities and enhancing ROS, abscisic acid and ethylene. This review explains the effects of bioherbicides (derived from plants and microbes) on weed-plant physiology to elucidate their modes of action. Copyright © 2018 Elsevier Inc. All rights reserved.

  2. Current trends on knowledge-based systems

    CERN Document Server

    Valencia-García, Rafael

    2017-01-01

    This book presents innovative and high-quality research on the implementation of conceptual frameworks, strategies, techniques, methodologies, informatics platforms and models for developing advanced knowledge-based systems and their application in different fields, including Agriculture, Education, Automotive, Electrical Industry, Business Services, Food Manufacturing, Energy Services, Medicine and others. Knowledge-based technologies employ artificial intelligence methods to heuristically address problems that cannot be solved by means of formal techniques. These technologies draw on standard and novel approaches from various disciplines within Computer Science, including Knowledge Engineering, Natural Language Processing, Decision Support Systems, Artificial Intelligence, Databases, Software Engineering, etc. As a combination of different fields of Artificial Intelligence, the area of Knowledge-Based Systems applies knowledge representation, case-based reasoning, neural networks, Semantic Web and TICs used...

  3. Baby walkers--health visitors' current practice, attitudes and knowledge.

    Science.gov (United States)

    Kendrick, Denise; Illingworth, Rachel; Hapgood, Rhydian; Woods, Amanda J; Collier, Jacqueline

    2003-09-01

    Baby walkers are a commonly used item of nursery equipment. Between 12% and 50% of parents whose infant uses a walker report that their child has suffered a walker-related injury. Health visitors' knowledge, attitudes and practice with regard to walkers and related health education has not been explored so far. The aim of the study was to describe health visitors' knowledge of walkers and walker-related injuries, their attitudes towards walkers and current practice with regard to walker health education, and to examine the relationship between knowledge and attitudes and knowledge and practice. A survey was carried out with 64 health visitors prior to participation in a randomized controlled trial assessing the effectiveness of an educational package in reducing baby walker use. The response rate was 95%. Half of the health visitors always discussed walkers postnatally, most frequently at the 6-9 month check. Most did not usually discuss the frequency of walker-related injuries. Most had negative attitudes towards walkers, but believed that parents hold positive attitudes to them and that it is hard to persuade parents not to use them. Health visitors had a limited knowledge of walker use and walker-related injuries. Those giving advice on walkers most often had higher knowledge scores than those giving advice less often (P = 0.03). Those with higher knowledge scores held more negative attitudes towards walkers (rs = 0.29, P = 0.023) and believed parents to have more positive attitudes towards walkers (rs = -0.49, P negotiating alternatives to their use. The provision of audio-visual aids for discussing walkers might also be helpful.

  4. Relational models for knowledge sharing behavior

    NARCIS (Netherlands)

    Boer, N.I.; Berends, J.J.; Baalen, P.

    2011-01-01

    In this paper we explore the relational dimension of knowledge sharing behavior by proposing a comprehensive theoretical framework for studying knowledge sharing in organizations. This theoretical framework originates from (Fiske, 1991) and (Fiske, 1992) Relational Models Theory (RMT). The RMT

  5. Awareness and current knowledge of breast cancer.

    Science.gov (United States)

    Akram, Muhammad; Iqbal, Mehwish; Daniyal, Muhammad; Khan, Asmat Ullah

    2017-10-02

    Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a positive impact on recognition and screening of breast cancer. Breast cancer is life-threatening disease in females and the leading cause of mortality among women population. For the previous two decades, studies related to the breast cancer has guided to astonishing advancement in our understanding of the breast cancer, resulting in further proficient treatments. Amongst all the malignant diseases, breast cancer is considered as one of the leading cause of death in post menopausal women accounting for 23% of all cancer deaths. It is a global issue now, but still it is diagnosed in their advanced stages due to the negligence of women regarding the self inspection and clinical examination of the breast. This review addresses anatomy of the breast, risk factors, epidemiology of breast cancer, pathogenesis of breast cancer, stages of breast cancer, diagnostic investigations and treatment including chemotherapy, surgery, targeted therapies, hormone replacement therapy, radiation therapy, complementary therapies, gene therapy and stem-cell therapy etc for breast cancer.

  6. Sleep bruxism: Current knowledge and contemporary management

    Science.gov (United States)

    Yap, Adrian U.; Chua, Ai Ping

    2016-01-01

    Bruxism is defined as the repetitive jaw muscle activity characterized by the clenching or grinding of teeth. It can be categorized into awake and sleep bruxism (SB). Frequent SB occurs in about 13% of adults. The exact etiology of SB is still unknown and probably multifactorial in nature. Current literature suggests that SB is regulated centrally (pathophysiological and psychosocial factors) and not peripherally (morphological factors). Cited consequences of SB include temporomandibular disorders, headaches, tooth wear/fracture, implant, and other restoration failure. Chairside recognition of SB involves the use of subjective reports, clinical examinations, and trial oral splints. Definitive diagnosis of SB can only be achieved using electrophysiological tools. Pharmacological, psychological, and dental strategies had been employed to manage SB. There is at present, no effective treatment that “cures” or “stops” SB permanently. Management is usually directed toward tooth/restoration protection, reduction of bruxism activity, and pain relief. PMID:27656052

  7. Parastomal hernia - current knowledge and treatment.

    Science.gov (United States)

    Styliński, Roman; Alzubedi, Adam; Rudzki, Sławomir

    2018-03-01

    Intestinal stoma creation is one of the most common surgical procedures. The most common long-term complication following stoma creation is parastomal hernia, which according to some authors is practically unavoidable. Statistical differences of its occurrence are mainly due to patient observation time and evaluation criteria. Consequently, primary prevention methods such as placement of prosthetic mesh and newly developed minimally invasive methods of stoma creation are used. It seems that in the light of evidence-based medicine, the best way to treat parastomal hernia is the one that the surgeon undertaking therapy is the most experienced in and is suited to the individuality of each patient, his condition and comorbidities. As a general rule, reinforcing the abdominal wall with a prosthetic mesh is the treatment of choice, with a low rate of complications and relapses over a long period of time. The current trend is to use lightweight, large pore meshes.

  8. Sleep bruxism: Current knowledge and contemporary management.

    Science.gov (United States)

    Yap, Adrian U; Chua, Ai Ping

    2016-01-01

    Bruxism is defined as the repetitive jaw muscle activity characterized by the clenching or grinding of teeth. It can be categorized into awake and sleep bruxism (SB). Frequent SB occurs in about 13% of adults. The exact etiology of SB is still unknown and probably multifactorial in nature. Current literature suggests that SB is regulated centrally (pathophysiological and psychosocial factors) and not peripherally (morphological factors). Cited consequences of SB include temporomandibular disorders, headaches, tooth wear/fracture, implant, and other restoration failure. Chairside recognition of SB involves the use of subjective reports, clinical examinations, and trial oral splints. Definitive diagnosis of SB can only be achieved using electrophysiological tools. Pharmacological, psychological, and dental strategies had been employed to manage SB. There is at present, no effective treatment that "cures" or "stops" SB permanently. Management is usually directed toward tooth/restoration protection, reduction of bruxism activity, and pain relief.

  9. Cetacean Morbillivirus: Current Knowledge and Future Directions

    Directory of Open Access Journals (Sweden)

    Marie-Françoise Van Bressem

    2014-12-01

    Full Text Available We review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV and the diagnosis and pathogenesis of associated disease, with six different strains detected in cetaceans worldwide. CeMV has caused epidemics with high mortality in odontocetes in Europe, the USA and Australia. It represents a distinct species within the Morbillivirus genus. Although most CeMV strains are phylogenetically closely related, recent data indicate that morbilliviruses recovered from Indo-Pacific bottlenose dolphins (Tursiops aduncus, from Western Australia, and a Guiana dolphin (Sotalia guianensis, from Brazil, are divergent. The signaling lymphocyte activation molecule (SLAM cell receptor for CeMV has been characterized in cetaceans. It shares higher amino acid identity with the ruminant SLAM than with the receptors of carnivores or humans, reflecting the evolutionary history of these mammalian taxa. In Delphinidae, three amino acid substitutions may result in a higher affinity for the virus. Infection is diagnosed by histology, immunohistochemistry, virus isolation, RT-PCR, and serology. Classical CeMV-associated lesions include bronchointerstitial pneumonia, encephalitis, syncytia, and lymphoid depletion associated with immunosuppression. Cetaceans that survive the acute disease may develop fatal secondary infections and chronic encephalitis. Endemically infected, gregarious odontocetes probably serve as reservoirs and vectors. Transmission likely occurs through the inhalation of aerosolized virus but mother to fetus transmission was also reported.

  10. Additive Manufacturing and Business Models: Current Knowledge and Missing Perspectives

    Directory of Open Access Journals (Sweden)

    Christina Öberg

    2018-06-01

    Full Text Available Additive manufacturing, that is 3D printing technology, may change the way companies operate their businesses. This article adopts a business model perspective to create an understanding of what we know about these changes. It summarizes current knowledge on additive manufacturing within management and business research, and it discusses future research directions in relation to business models for additive manufacturing. Using the scientific database Web of Science, 116 journal articles were identified. The literature review reveals that most research concerns manufacturing optimization. A more holistic view of the changes that additive manufacturing may bring about for firms is needed, as is more research on changed value propositions, and customer/sales-related issues. The article contributes to previous research by systematically summarizing additive manufacturing research in the business and management literature, and by highlighting areas for further investigation related to the business models of individual firms.

  11. Climate change impacts in Northern Canada: Assessing our current knowledge

    Energy Technology Data Exchange (ETDEWEB)

    Gill, M.J.; Eamer, J. [Environment Canada, Environmental Conservation Branch, Whitehorse, YT (Canada); Munier, A.; Ogden, A. [Yukon College, Northern Climate ExChange, Whitehorse, YT (Canada); Duerden, F. [Ryerson University, School of Applied Geography, Toronto, ON (Canada); Hik, D. [Alberta Univ., Dept. of Biological Sciences, Edmonton, AB (Canada); Fox, S.; Riedlinger, D.; Thorpe, N. [GeoNorth Limited, Whitehorse, YT (Canada); Johnson, I.; Jensen, M. [Legend Seekers Anthropological Research, Whitehorse, YT (Canada)

    2001-07-01

    A research project by the Northern Climate ExChange at Yukon College, undertaken to bring together into one document all relevant information that will help facilitate the identification of priorities for climate change research, monitoring, technological development and policy development in Canada's North, is described. In addition to the report, project deliverables also include a database of climate change information sources and a database of northern climate change contacts. The review includes scientific, local and Traditional Knowledge sources relating to climate change about each of seventeen natural and human systems (e.g. boreal forests, community health, mining, etc.), synthesized into a table for each system, with projected environmental changes crossed in matrix format with system components. Each cross-relationship was given a ranking; supporting information was included, based on the current state of knowledge of that relationship. In general, current information concerning northern systems, predicted climate changes and the impacts of those changes on northern systems is poor. However, much information does exist and the gap analysis revealed a number of general patterns relating to this information. Clearly, more research is required throughout northern Canada, but in particular, in the eastern Arctic, to provide a greater understanding of the implications of climate changes across the North, and to aid in the development of finer-scale, regional circulation models resulting in better predictive capacity of climate change and its impacts on northern areas.

  12. Relational knowledge leadership and local economic development

    OpenAIRE

    Horlings, Lummina; Collinge, Chris; Gibney, John

    2017-01-01

    This paper concerns the role of spatial leadership in the development of the knowledge-based economy. It is argued within academic and practitioner circles that leadership of knowledge networks requires a particular non-hierarchical style that is required to establish an ambience conducive to networking and knowledge sharing across boundaries. In this paper, we explore this hypothesis at both theoretical and empirical levels. Theoretically, we propose a conceptualization of relational knowled...

  13. Current state about the cuaternary knowledge of Uruguay

    International Nuclear Information System (INIS)

    Anton, D; Goso, H.

    1974-01-01

    This work is about current state of cuaternary knowledge Uruguayan. It is considered that the cuaternary presented a change from the hot and dry weather of the Pliocene to more humid and colder weather in Uruguay.

  14. Diuretics in pediatrics: Current knowledge and future prospects

    NARCIS (Netherlands)

    M.M.J. van der Vorst (Maria); M. Kist (Manfred); A.J. van der Heijden (Bert); J. Burggraaf (Jacobus)

    2006-01-01

    textabstractThis review summarizes current knowledge on the pharmacology, pharmacokinetics, pharmacodynamics, and clinical application of the most commonly used diuretics in children. Diuretics are frequently prescribed drugs in children. Their main indication is to reduce fluid overload in acute

  15. Deposition and interception of radionuclides. Current knowledge and future requirements

    International Nuclear Information System (INIS)

    1998-12-01

    Following an accidental or routine release of radionuclides into the environment, a good knowledge of deposition processes is necessary in order to accurately predict the radiation dose to members of the public. In order to understand the environmental impact of released radionuclides and their transfer through the environment, including the food chain to man, there have been numerous studies on deposition of radionuclides to a range of surfaces such as bare soil, crops, forests, water bodies and urban surfaces. The RADREM committee provides a forum for liaison on UK research and monitoring in the areas of radioactive substances and radioactive waste management. RADREM has set up four sub-committees to cover issues related to radioactivity in the atmospheric, terrestrial and aquatic environments as well as those related radioactive waste management. One of the sub-committee tasks is to organise seminars and workshops on specific topics of interest. The first of these was the workshop on 'Deposition and Interception of Radionuclides: Current knowledge and future requirements' organised last year by the Ministry of Agriculture, Fisheries and Food (MAFF), acting as secretariat for the Terrestrial Environment Sub-Committee (TESC) of RADREM. The intent of this workshop was to provide an opportunity to exchange information on deposition-related aspects between representatives from various interested parties including government, regulatory bodies, industry and research organisations. Through presentations and discussions, this workshop addressed current developments in the areas of deposition and interception of radionuclides by various surfaces and served to identify areas which need further research. Papers were presented on various aspects of deposition and interception of radionuclides including deposition into grass, fruits and other crops as well as deposition into urban areas and forests

  16. Human Immunodeficiency Virus Related Knowledge, Risk ...

    African Journals Online (AJOL)

    There was poor HIV preventive practices; indicating ... Gyawali, et al.: HIV related knowledge, risk perception and practices among married women. Annals of Medical .... of this study correspond to the Indian, Nigerian and Iranian studies cited ...

  17. Relations among conceptual knowledge, procedural knowledge, and procedural flexibility in two samples differing in prior knowledge.

    Science.gov (United States)

    Schneider, Michael; Rittle-Johnson, Bethany; Star, Jon R

    2011-11-01

    Competence in many domains rests on children developing conceptual and procedural knowledge, as well as procedural flexibility. However, research on the developmental relations between these different types of knowledge has yielded unclear results, in part because little attention has been paid to the validity of the measures or to the effects of prior knowledge on the relations. To overcome these problems, we modeled the three constructs in the domain of equation solving as latent factors and tested (a) whether the predictive relations between conceptual and procedural knowledge were bidirectional, (b) whether these interrelations were moderated by prior knowledge, and (c) how both constructs contributed to procedural flexibility. We analyzed data from 2 measurement points each from two samples (Ns = 228 and 304) of middle school students who differed in prior knowledge. Conceptual and procedural knowledge had stable bidirectional relations that were not moderated by prior knowledge. Both kinds of knowledge contributed independently to procedural flexibility. The results demonstrate how changes in complex knowledge structures contribute to competence development.

  18. Knowledge work and work-related stress

    DEFF Research Database (Denmark)

    Ipsen, Christine

    2006-01-01

    Work-related stress is an increasing problem in Europe. Earlier studies have stated that knowledge-work comprises working conditions which reflect a good psychosocial environment. Recent Danish studies, however, point at stress being an increasing problem in knowledge-intensive companies...... with informally, individu-ally and incidentally. It is only when problems exist that enhanced support is offered in order to help an employee to cope or recover. As most workplace initiatives work at this tertiary level, the sources of work-related and organiza-tional stress are not reduced or eliminated...... as good and stimulating, but has on the other hand sides to it which can cause frustration and stress. The implication of organisational characteristics of the knowledge-intensive companies studied is a transfer of the responsibility for ones own working-life. Consequently, issues are dealt...

  19. Occupational Therapy in Preschools: A Synthesis of Current Knowledge

    Science.gov (United States)

    Jasmin, Emmanuelle; Gauthier, Anne; Julien, Marjorie; Hui, Caroline

    2018-01-01

    This paper presents a synthesis of current knowledge about occupational therapy in preschools (for 3-6 year olds) in order to provide a better understanding of this field of practice and to guide the implementation or programming of this service. In the literature, occupational therapy in preschools has been documented mainly in the USA. Results…

  20. Phocine distemper virus: current knowledge and future directions.

    Science.gov (United States)

    Duignan, Pádraig J; Van Bressem, Marie-Françoise; Baker, Jason D; Barbieri, Michelle; Colegrove, Kathleen M; De Guise, Sylvain; de Swart, Rik L; Di Guardo, Giovanni; Dobson, Andrew; Duprex, W Paul; Early, Greg; Fauquier, Deborah; Goldstein, Tracey; Goodman, Simon J; Grenfell, Bryan; Groch, Kátia R; Gulland, Frances; Hall, Ailsa; Jensen, Brenda A; Lamy, Karina; Matassa, Keith; Mazzariol, Sandro; Morris, Sinead E; Nielsen, Ole; Rotstein, David; Rowles, Teresa K; Saliki, Jeremy T; Siebert, Ursula; Waltzek, Thomas; Wellehan, James F X

    2014-12-22

    Phocine distemper virus (PDV) was first recognized in 1988 following a massive epidemic in harbor and grey seals in north-western Europe. Since then, the epidemiology of infection in North Atlantic and Arctic pinnipeds has been investigated. In the western North Atlantic endemic infection in harp and grey seals predates the European epidemic, with relatively small, localized mortality events occurring primarily in harbor seals. By contrast, PDV seems not to have become established in European harbor seals following the 1988 epidemic and a second event of similar magnitude and extent occurred in 2002. PDV is a distinct species within the Morbillivirus genus with minor sequence variation between outbreaks over time. There is now mounting evidence of PDV-like viruses in the North Pacific/Western Arctic with serological and molecular evidence of infection in pinnipeds and sea otters. However, despite the absence of associated mortality in the region, there is concern that the virus may infect the large Pacific harbor seal and northern elephant seal populations or the endangered Hawaiian monk seals. Here, we review the current state of knowledge on PDV with particular focus on developments in diagnostics, pathogenesis, immune response, vaccine development, phylogenetics and modeling over the past 20 years.

  1. Phocine Distemper Virus: Current Knowledge and Future Directions

    Directory of Open Access Journals (Sweden)

    Pádraig J. Duignan

    2014-12-01

    Full Text Available Phocine distemper virus (PDV was first recognized in 1988 following a massive epidemic in harbor and grey seals in north-western Europe. Since then, the epidemiology of infection in North Atlantic and Arctic pinnipeds has been investigated. In the western North Atlantic endemic infection in harp and grey seals predates the European epidemic, with relatively small, localized mortality events occurring primarily in harbor seals. By contrast, PDV seems not to have become established in European harbor seals following the 1988 epidemic and a second event of similar magnitude and extent occurred in 2002. PDV is a distinct species within the Morbillivirus genus with minor sequence variation between outbreaks over time. There is now mounting evidence of PDV-like viruses in the North Pacific/Western Arctic with serological and molecular evidence of infection in pinnipeds and sea otters. However, despite the absence of associated mortality in the region, there is concern that the virus may infect the large Pacific harbor seal and northern elephant seal populations or the endangered Hawaiian monk seals. Here, we review the current state of knowledge on PDV with particular focus on developments in diagnostics, pathogenesis, immune response, vaccine development, phylogenetics and modeling over the past 20 years.

  2. Current Concepts in Sports-Related Concussion.

    Science.gov (United States)

    Chatterjee, Dipal; Frumberg, David B; Mulchandani, Neil B; Eldib, Ahmed M; Xavier, Fred; Barbash, Scott E; Saha, Subrata; Urban, William P

    2015-01-01

    Traumatic brain injury, specifically concussion, is prevalent in contact sports. In the United States (US) each year, 170 million adults participate in physical recreational activities, and 38 million children and adolescents participate in organized sports. The Centers for Disease Control estimate that in this group ~1.6 to 3.8 million concussions occur annually. Recent class-action lawsuits in the US filed by professional athletes against their respective leagues allege negligence in protecting them from concussions, and this has contributed to the attention received in the popular media. In response, concussion-related publications have increased exponentially during the past several years. Recent studies have challenged earlier assumptions that the effects of concussion are transient. Stronger links between concussion and neurodegenerative processes such as Alzheimer's disease-like conditions, depression, and heightened risk for suicide are being elucidated. In this article, we explore the current knowledge on concussion, including pathophysiology, management, and long-term effects. We conclude that more evidence-based results regarding guidelines for diagnosis, treatment, and return to play (RTP) are needed and should be the focus of future investigations. Attributing the etiology of certain neurodegenerative conditions to a history of concussion has been suggested in the current literature, but additional quantitative data regarding the pathophysiology and causality are needed as well. Bioengineers can have an important role in measuring the dynamic forces encountered during head impacts and their effects on the brain. These results can be effective in designing better helmets as well as improved playing surfaces to reduce the impact of such injuries. At this time, we believe that groups of people with heightened risk for concussion should be followed closely during longer periods of time and compared to matched controls. Such long-term studies are urgently

  3. Detecting misinformation and knowledge conflicts in relational data

    Science.gov (United States)

    Levchuk, Georgiy; Jackobsen, Matthew; Riordan, Brian

    2014-06-01

    Information fusion is required for many mission-critical intelligence analysis tasks. Using knowledge extracted from various sources, including entities, relations, and events, intelligence analysts respond to commander's information requests, integrate facts into summaries about current situations, augment existing knowledge with inferred information, make predictions about the future, and develop action plans. However, information fusion solutions often fail because of conflicting and redundant knowledge contained in multiple sources. Most knowledge conflicts in the past were due to translation errors and reporter bias, and thus could be managed. Current and future intelligence analysis, especially in denied areas, must deal with open source data processing, where there is much greater presence of intentional misinformation. In this paper, we describe a model for detecting conflicts in multi-source textual knowledge. Our model is based on constructing semantic graphs representing patterns of multi-source knowledge conflicts and anomalies, and detecting these conflicts by matching pattern graphs against the data graph constructed using soft co-reference between entities and events in multiple sources. The conflict detection process maintains the uncertainty throughout all phases, providing full traceability and enabling incremental updates of the detection results as new knowledge or modification to previously analyzed information are obtained. Detected conflicts are presented to analysts for further investigation. In the experimental study with SYNCOIN dataset, our algorithms achieved perfect conflict detection in ideal situation (no missing data) while producing 82% recall and 90% precision in realistic noise situation (15% of missing attributes).

  4. Azelaic acid in dermatological treatment – current state of knowledge

    Directory of Open Access Journals (Sweden)

    Radomir Reszke

    2016-09-01

    Full Text Available Azelaic acid (AZA is a naturally occurring substance produced by Malassezia furfur which exerts various effects on the skin. Azelaic acid has antibacterial, anti-inflammatory, keratolytic, comedolytic, sebostatic and tyrosinase-inhibiting properties. Topical application of AZA as 20% cream or 15% gel is a well-established therapeutic method in various common dermatoses, mainly acne vulgaris, rosacea and disorders associated with hyperpigmentation. Azelaic acid is used as a component of chemical peels as well. The paper summarizes the most relevant issues concerning AZA application in dermatological treatment based on current knowledge.

  5. Auditing Associative Relations across Two Knowledge Sources

    Science.gov (United States)

    Vizenor, Lowell T.; Bodenreider, Olivier; McCray, Alexa T.

    2009-01-01

    Objectives This paper proposes a novel semantic method for auditing associative relations in biomedical terminologies. We tested our methodology on two Unified Medical Language System (UMLS) knowledge sources. Methods We use the UMLS semantic groups as high-level representations of the domain and range of relationships in the Metathesaurus and in the Semantic Network. A mapping created between Metathesaurus relationships and Semantic Network relationships forms the basis for comparing the signatures of a given Metathesaurus relationship to the signatures of the semantic relationship to which it is mapped. The consistency of Metathesaurus relations is studied for each relationship. Results Of the 177 associative relationships in the Metathesaurus, 84 (48%) exhibit a high degree of consistency with the corresponding Semantic Network relationships. Overall, 63% of the 1.8M associative relations in the Metathesaurus are consistent with relations in the Semantic Network. Conclusion The semantics of associative relationships in biomedical terminologies should be defined explicitly by their developers. The Semantic Network would benefit from being extended with new relationships and with new relations for some existing relationships. The UMLS editing environment could take advantage of the correspondence established between relationships in the Metathesaurus and the Semantic Network. Finally, the auditing method also yielded useful information for refining the mapping of associative relationships between the two sources. PMID:19475724

  6. Climate change impacts in Iran: assessing our current knowledge

    Science.gov (United States)

    Rahimi, Jaber; Malekian, Arash; Khalili, Ali

    2018-02-01

    During recent years, various studies have focused on investigating the direct and indirect impacts of climate changes in Iran while the noteworthy fact is the achievement gained by these researches. Furthermore, what should be taken into consideration is whether these studies have been able to provide appropriate opportunities for improving further studies in this particular field or not. To address these questions, this study systematically reviewed and summarized the current available literature (n = 150) regarding the impacts of climate change on temperature and precipitation in Iran to assess our current state of knowledge. The results revealed that while all studies discuss the probable changes in temperature and precipitation over the next decades, serious contradictions could be seen in their results; also, the general pattern of changes was different in most of the cases. This matter may have a significant effect on public beliefs in climate change, which can be a serious warning for the activists in this realm.

  7. Parents' reading-related knowledge and children's reading acquisition.

    Science.gov (United States)

    Ladd, Megan; Martin-Chang, Sandra; Levesque, Kyle

    2011-12-01

    Teacher reading-related knowledge (phonological awareness and phonics knowledge) predicts student reading, however little is known about the reading-related knowledge of parents. Participants comprised 70 dyads (children from kindergarten and grade 1 and their parents). Parents were administered a questionnaire tapping into reading-related knowledge, print exposure, storybook reading, and general cultural knowledge. Children were tested on measures of letter-word knowledge, sound awareness, receptive vocabulary, oral expression, and mathematical skill. Parent reading-related knowledge showed significant positive links with child letter-word knowledge and sound awareness, but showed no correlations with child measures of mathematical skill or vocabulary. Furthermore, parent reading-related knowledge was not associated with parents' own print exposure or cultural knowledge, indicating that knowledge about English word structure may be separate from other cognitive skills. Implications are discussed in terms of improving parent reading-related knowledge to promote child literacy.

  8. Current Knowledge and Recent Advances in Marine Dinoflagellate Transcriptomic Research

    Directory of Open Access Journals (Sweden)

    Muhamad Afiq Akbar

    2018-02-01

    Full Text Available Dinoflagellates are essential components in marine ecosystems, and they possess two dissimilar flagella to facilitate movement. Dinoflagellates are major components of marine food webs and of extreme importance in balancing the ecosystem energy flux in oceans. They have been reported to be the primary cause of harmful algae bloom (HABs events around the world, causing seafood poisoning and therefore having a direct impact on human health. Interestingly, dinoflagellates in the genus Symbiodinium are major components of coral reef foundations. Knowledge regarding their genes and genome organization is currently limited due to their large genome size and other genetic and cytological characteristics that hinder whole genome sequencing of dinoflagellates. Transcriptomic approaches and genetic analyses have been employed to unravel the physiological and metabolic characteristics of dinoflagellates and their complexity. In this review, we summarize the current knowledge and findings from transcriptomic studies to understand the cell growth, effects on environmental stress, toxin biosynthesis, dynamic of HABs, phylogeny and endosymbiosis of dinoflagellates. With the advancement of high throughput sequencing technologies and lower cost of sequencing, transcriptomic approaches will likely deepen our understanding in other aspects of dinoflagellates’ molecular biology such as gene functional analysis, systems biology and development of model organisms.

  9. Nuclear power reactor core melt accidents. Current State of Knowledge

    International Nuclear Information System (INIS)

    Jacquemain, Didier; Cenerino, Gerard; Corenwinder, Francois; Raimond, Emmanuel IRSN; Bentaib, Ahmed; Bonneville, Herve; Clement, Bernard; Cranga, Michel; Fichot, Florian; Koundy, Vincent; Meignen, Renaud; Corenwinder, Francois; Leteinturier, Denis; Monroig, Frederique; Nahas, Georges; Pichereau, Frederique; Van-Dorsselaere, Jean-Pierre; Couturier, Jean; Debaudringhien, Cecile; Duprat, Anna; Dupuy, Patricia; Evrard, Jean-Michel; Nicaise, Gregory; Berthoud, Georges; Studer, Etienne; Boulaud, Denis; Chaumont, Bernard; Clement, Bernard; Gonzalez, Richard; Queniart, Daniel; Peltier, Jean; Goue, Georges; Lefevre, Odile; Marano, Sandrine; Gobin, Jean-Dominique; Schwarz, Michel; Repussard, Jacques; Haste, Tim; Ducros, Gerard; Journeau, Christophe; Magallon, Daniel; Seiler, Jean-Marie; Tourniaire, Bruno; Durin, Michel; Andreo, Francois; Atkhen, Kresna; Daguse, Thierry; Dubreuil-Chambardel, Alain; Kappler, Francois; Labadie, Gerard; Schumm, Andreas; Gauntt, Randall O.; Birchley, Jonathan

    2015-11-01

    For over thirty years, IPSN and subsequently IRSN has played a major international role in the field of nuclear power reactor core melt accidents through the undertaking of important experimental programmes (the most significant being the Phebus-FP programme), the development of validated simulation tools (the ASTEC code that is today the leading European tool for modelling severe accidents), and the coordination of the SARNET (Severe Accident Research Network) international network of excellence. These accidents are described as 'severe accidents' because they can lead to radioactive releases outside the plant concerned, with serious consequences for the general public and for the environment. This book compiles the sum of the knowledge acquired on this subject and summarises the lessons that have been learnt from severe accidents around the world for the prevention and reduction of the consequences of such accidents, without addressing those from the Fukushima accident, where knowledge of events is still evolving. The knowledge accumulated by the Institute on these subjects enabled it to play an active role in informing public authorities, the media and the public when this accident occurred, and continues to do so to this day. Following the introduction, which describes the structure of this book and highlights the objectives of R and D on core melt accidents, this book briefly presents the design and operating principles (Chapter 2) and safety principles (Chapter 3) of the reactors currently in operation in France, as well as the main accident scenarios envisaged and studied (Chapter 4). The objective of these chapters is not to provide exhaustive information on these subjects (the reader should refer to the general reference documents listed in the corresponding chapters), but instead to provide the information needed in order to understand, firstly, the general approach adopted in France for preventing and mitigating the consequences of core melt

  10. Autophagy in Drosophila: From Historical Studies to Current Knowledge

    Science.gov (United States)

    Mulakkal, Nitha C.; Nagy, Peter; Takats, Szabolcs; Tusco, Radu; Juhász, Gábor; Nezis, Ioannis P.

    2014-01-01

    The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field and made it possible to carry out functional studies on model organisms. Insects including Drosophila are classical and still popular models to study autophagy, starting from the 1960s. This review aims to summarize past achievements and our current knowledge about the role and regulation of autophagy in Drosophila, with an outlook to yeast and mammals. The basic mechanisms of autophagy in fruit fly cells appear to be quite similar to other eukaryotes, and the role that this lysosomal self-degradation process plays in Drosophila models of various diseases already made it possible to recognize certain aspects of human pathologies. Future studies in this complete animal hold great promise for the better understanding of such processes and may also help finding new research avenues for the treatment of disorders with misregulated autophagy. PMID:24949430

  11. Autophagy in Drosophila: From Historical Studies to Current Knowledge

    Directory of Open Access Journals (Sweden)

    Nitha C. Mulakkal

    2014-01-01

    Full Text Available The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field and made it possible to carry out functional studies on model organisms. Insects including Drosophila are classical and still popular models to study autophagy, starting from the 1960s. This review aims to summarize past achievements and our current knowledge about the role and regulation of autophagy in Drosophila, with an outlook to yeast and mammals. The basic mechanisms of autophagy in fruit fly cells appear to be quite similar to other eukaryotes, and the role that this lysosomal self-degradation process plays in Drosophila models of various diseases already made it possible to recognize certain aspects of human pathologies. Future studies in this complete animal hold great promise for the better understanding of such processes and may also help finding new research avenues for the treatment of disorders with misregulated autophagy.

  12. Cyanobactins from Cyanobacteria: Current Genetic and Chemical State of Knowledge.

    Science.gov (United States)

    Martins, Joana; Vasconcelos, Vitor

    2015-11-13

    Cyanobacteria are considered to be one of the most promising sources of new, natural products. Apart from non-ribosomal peptides and polyketides, ribosomally synthesized and post-translationally modified peptides (RiPPs) are one of the leading groups of bioactive compounds produced by cyanobacteria. Among these, cyanobactins have sparked attention due to their interesting bioactivities and for their potential to be prospective candidates in the development of drugs. It is assumed that the primary source of cyanobactins is cyanobacteria, although these compounds have also been isolated from marine animals such as ascidians, sponges and mollusks. The aim of this review is to update the current knowledge of cyanobactins, recognized as being produced by cyanobacteria, and to emphasize their genetic clusters and chemical structures as well as their bioactivities, ecological roles and biotechnological potential.

  13. Microbiological risk factors in dentistry. Current status of knowledge.

    Science.gov (United States)

    Szymańska, Jolanta

    2005-01-01

    Dentists belong to a professional group potentially exposed to harmful biological factors which most often are infectious microorganisms, less frequently - allergenic or toxic microorganisms. The fundamental routes of spreading harmful microorganisms in a dental surgery are: blood-borne, saliva-droplet, direct contact with a patient and with infected equipment, and water-droplet infections. In this paper, the current status of knowledge on microbiological hazards in a dentist's work is presented. Groups of microorganisms, such as prions, viruses, bacteria, fungi and protozoa, to which a dentist is, or may be exposed, are discussed. Epidemiological assessment of microbiological hazards in a dentist's work was performed and the basic principles of prevention formulated. Special attention was given to microflora in dental unit waterlines, and the biofilm persisting in them, as a source of occupational hazards specific for a dentist's workplace.

  14. Brown carbon in the cryosphere: Current knowledge and perspective

    Directory of Open Access Journals (Sweden)

    Guang-Ming Wu

    2016-03-01

    Full Text Available Recently, the light-absorbing organic carbon, i.e., brown carbon (BrC, has received an increasing attention, because they could significantly absorb the solar radiation in the range of short wavelengths rather than the purely scattering effect. BrC is ubiquitous in the troposphere. It could undergo long range transport within the atmospheric circulation. After the deposition on the surface of snow or ice in the cryospheric region, as the major light absorbing impurities with black carbon and dust, BrC could reduce the snow albedo and accelerate the glacier melting. In this context, this paper summarized the current knowledge of BrC (in aerosols and snow in the cryospheric regions including the Arctic, Antarctic, and Alpines. Although some works have been conducted in those region, the current dataset on the optical properties of BrC like Absorption Ångström Exponent (AAE and Mass Absorption Efficiency (MAE is still limited, which hampers stimulating an accurate evaluation of its climate effects. Especially in the Himalayas and Tibetan Plateau, where very limited information concerning BrC is available. Considering biomass burning as a dominant source of BrC, a large amount of emissions from biomass burning in South Asia could reach the Himalayas and Tibetan Plateau, where the climate effect of BrC merits more investigation in the future.

  15. Relational knowledge leadership and local economic development

    NARCIS (Netherlands)

    Horlings, Lummina; Collinge, Chris; Gibney, John

    2017-01-01

    This paper concerns the role of spatial leadership in the development of the knowledge-based economy. It is argued within academic and practitioner circles that leadership of knowledge networks requires a particular non-hierarchical style that is required to establish an ambience conducive to

  16. A VIEWPOINT ON THE CURRENT STATE OF KNOWLEDGE MANAGEMENT INSTRUMENTS

    Directory of Open Access Journals (Sweden)

    ANDREEA PAULA DUMITRU

    2011-04-01

    Full Text Available Knowledge management is seeking solutions to harmonize the objectives of organizations of the human group, which need to rationalize, to provide policy makers and to implement. This article aims to provide readers with an introduction to knowledge management basic definitions, theories and concepts such as types of knowledge, the differences between data, information and knowledge, etc, are given. But, why we need a knowledge management ? This article justified the need for companies to focus management efforts on their intangible elements and provides the five enabling conditions for knowledge creation.

  17. Current expertise location by exploiting the dynamics of knowledge

    Directory of Open Access Journals (Sweden)

    Josef Nozicka

    2012-10-01

    Full Text Available Systems for expertise location are either very expensive in terms of the costs of maintenance or they tend to become obsolete or incomplete during the time. This article presents a new approach to knowledge mapping/expertise location allowing reducing the costs of knowledge mapping by maintaining the accuracy of the knowledge map. The efficiency of the knowledge map is achieved by introducing the knowledge estimation measures analysing the dynamics of knowledge of company employees and their textual results of work. Finding an expert with most up-to date knowledge is supported by focusing publishing history analysis. The efficiency of proposed measures within various timeframes of publishing history is evaluated by evaluation method introduced within the article. The evaluation took place in the environment of a middle-sized software company allowing seeing directly a practical usability of the expertise location technique. The results form various implications deployment of knowledge map within the company.

  18. Understanding the Climate-knowledge Sharing Relation

    DEFF Research Database (Denmark)

    Llopis, Oscar; Foss, Nicolai Juul

    2016-01-01

    motivation and job autonomy as moderators of this relationship. We find that the social climate for cooperation better predicts knowledge sharing when employees show low levels of intrinsic motivation and have high levels of job autonomy. This suggests that a cooperative climate and intrinsic motivation...... are substitutes with respect to their impact on knowledge-sharing behaviors, while climate and job autonomy are complements. We find support for these ideas in data gathered from a sample of 170 employees of a knowledge-intensive firm....

  19. Knowledge related activities in open innovation

    DEFF Research Database (Denmark)

    Pedrosa, Alex; Välling, Margus; Boyd, Britta

    2013-01-01

    interaction in open innovation. Despite valuable insights into the importance of the variety of external knowledge sources to enhance (open) innovation, research has overlooked so far that managers’ characteristics and practices are relevant for the absorption of external knowledge in open innovation. Thus......Theory and practice both have recognised the importance of external knowledge to enhance organisations’ innovation performance. Due to organisations’ growing interest in effectively collaborating with external knowledge sources, research has investigated the importance of firm-external stakeholder......, the purpose of this study is to explore how organisations’ absorptive capacity – exploration, transformation, and exploitation – becomes manifested in managers’ characteristics and practices in open innovation. This article reports on the findings obtained from four case studies of manufacturing and service...

  20. Current knowledge and treatment strategies for grade II gliomas

    International Nuclear Information System (INIS)

    Narita, Yoshitaka

    2013-01-01

    World Health Organization grade II gliomas (GIIGs) include diffuse astrocytoma, oligodendroglioma, and oligoastrocytoma. GIIG is a malignant brain tumor for which the treatment outcome can still be improved. Review of previous clinical trials found the following: GIIG increased in size by 3-5 mm per year when observed or treated with surgery alone; after pathological diagnosis, the survival rate was increased by early aggressive tumor removal at an earlier stage compared to observation alone; although the prognosis after total tumor removal was significantly better than that after partial tumor removal, half of the patients relapsed within 5 years; comparing postoperative early radiotherapy (RT) and non-early RT after relapse, early RT prolonged progression-free survival (PFS) but did not affect overall survival (OS); local RT of 45 to 64.8 Gy did not impact PFS or OS; in patients with residual tumors, RT combined with chemotherapy (procarbazine plus lomustine plus vincristine) prolonged PFS compared with RT alone but did not affect OS; and poor prognostic factors included astrocytoma, non-total tumor removal, age ≥40 years, largest tumor diameter ≥4-6 cm, tumor crossing the midline, and neurological deficit. To improve treatment outcomes, surgery with functional brain mapping or intraoperative magnetic resonance imaging or chemoradiotherapy with temozolomide is important. In this review, current knowledge regarding GIIG is described and treatment strategies are explored. (author)

  1. Current status of knowledge on public-speaking anxiety.

    Science.gov (United States)

    Pull, Charles B

    2012-01-01

    This review examines the current knowledge on public-speaking anxiety, that is, the fear of speaking in front of others. This article summarizes the findings from previous review articles and describes new research findings on basic science aspects, prevalence rates, classification, and treatment that have been published between August 2008 and August 2011. Recent findings highlight the major aspects of psychological and physiological reactivity to public speaking in individuals who are afraid to speak in front of others, confirm high prevalence rates of the disorder, contribute to identifying the disorder as a possibly distinct subtype of social anxiety disorder (SAD), and give support to the efficacy of treatment programs using virtual reality exposure and Internet-based self-help. Public-speaking anxiety is a highly prevalent disorder, leading to excessive psychological and physiological reactivity. It is present in a majority of individuals with SAD and there is substantial evidence that it may be a distinct subtype of SAD. It is amenable to treatment including, in particular, new technologies such as exposure to virtual environments and the use of cognitive-behavioral self-help programs delivered on the Internet.

  2. Engineered nanoparticles at the workplace: current knowledge about workers' risk.

    Science.gov (United States)

    Pietroiusti, A; Magrini, A

    2014-07-01

    The novel physicochemical properties of engineered nanoparticles (ENPs) make them very attractive for industrial and biomedical purposes, but concerns have been raised regarding unpredictable adverse health effects in humans. Current evidence for the risk posed by ENPs to exposed workers is the subject of this review. To perform an in-depth review of the state of art of nanoparticle exposure at work. Original articles and reviews in Pubmed and in principal databases of medical literature up to 2013 were included in the analysis. In addition, grey literature released by qualified regulatory agencies and by governmental and non-governmental organizations was also taken into consideration. There are significant knowledge and technical gaps to be filled for a reliable evaluation of the risk posed for workers by ENPs. Evidence for potential workplace release of ENPs however seems substantial, and the amount of exposure may exceed the proposed occupational exposure limits (OELs). The rational use of conventional engineering measures and of protective personal equipment seems to mitigate the risk. A precautionary approach is recommended for workplace exposure to ENPs, until health-based OELs are developed and released by official regulatory agencies. © The Author 2014. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  3. Microorganisms in Fermented Apple Beverages: Current Knowledge and Future Directions.

    Science.gov (United States)

    Cousin, Fabien J; Le Guellec, Rozenn; Schlusselhuber, Margot; Dalmasso, Marion; Laplace, Jean-Marie; Cretenet, Marina

    2017-07-25

    Production of fermented apple beverages is spread all around the world with specificities in each country. 'French ciders' refer to fermented apple juice mainly produced in the northwest of France and often associated with short periods of consumption. Research articles on this kind of product are scarce compared to wine, especially on phenomena associated with microbial activities. The wine fermentation microbiome and its dynamics, organoleptic improvement for healthy and pleasant products and development of starters are now widely studied. Even if both beverages seem close in terms of microbiome and process (with both alcoholic and malolactic fermentations), the inherent properties of the raw materials and different production and environmental parameters make research on the specificities of apple fermentation beverages worthwhile. This review summarizes current knowledge on the cider microbial ecosystem, associated activities and the influence of process parameters. In addition, available data on cider quality and safety is reviewed. Finally, we focus on the future role of lactic acid bacteria and yeasts in the development of even better or new beverages made from apples.

  4. HIV and AIDS-related knowledge among women in Iraq

    Directory of Open Access Journals (Sweden)

    Rudatsikira Emmanuel

    2008-12-01

    Full Text Available Abstract Background Individuals who are aware of the risk of infection and perceive themselves to be at risk of infection are more likely to take action to prevent HIV infection. The aim of this study was to assess the knowledge of HIV/AIDS among Iraqi women. Methods A secondary analysis of the 2000 Multiple Cluster Indicator Survey (MICS for Iraq was carried out to assess the extent of HIV/AIDS-related knowledge among Iraqi women. Results The majority of the 22,997 respondents were age 15–24 years (44.3%, currently married (51.4%, and resided in urban areas (71.7%. About 1 in 4 (26.0% of the study participants had no formal education. Only 49.9% had heard of HIV/AIDS. Overall, 60.5% did not know that HIV can be transmitted through blood transfusion. Meanwhile, 98.5% of the respondents did not know that HIV can be transmitted from mother to child through breast milk. Only 0.7% of the respondents reported that HIV cannot be transmitted through mosquito bites. The proportion of the respondents who had adequate knowledge on HIV/AIDS was 9.8%. Adequate knowledge of HIV/AIDS was negatively associated with being married, poor, having low education, and residing in rural areas. Conclusion Findings from this study indicate that adequate knowledge of HIV/AIDS among Iraqi is very limited and associated with marital status, education, wealth, and place of residence. This information may be of use in the design, targeting, monitoring and evaluation of programs aimed at improving HIV and AIDS related knowledge in Iraq.

  5. Oxytocin and Socioemotional Aging─Current Knowledge and Future Trends

    Directory of Open Access Journals (Sweden)

    Natalie C. Ebner

    2013-08-01

    Full Text Available The oxytocin (OT system is involved in various aspects of social cognition and prosocial behavior. Specifically, OT has been examined in the context of social memory, emotion recognition, cooperation, trust, empathy, and bonding, and─though evidence is somewhat mixed─intranasal OT appears to benefit aspects of socioemotional functioning. However, most of the extant data on aging and OT is from animal research and human OT research has focused largely on young adults. As such, though we know that various socioemotional capacities change with age, we know little about whether age-related changes in the OT system may underlie age-related differences in socioemotional functioning. In this review, we take a genetic-neuro-behavioral approach and evaluate current evidence on age-related changes in the OT system as well as the putative effects of these alterations on age-related socioemotional functioning. Looking forward, we identify informational gaps and propose an Age-Related Genetic, Neurobiological, Sociobehavioral Model of Oxytocin (AGeNeS-OT model which may structure and inform investigations into aging-related genetic, neural, and sociocognitive processes related to OT. As an exemplar of the use of the model, we report exploratory data suggesting differences in socioemotional processing associated with genetic variation in the oxytocin receptor gene (OXTR in samples of young and older adults. Information gained from this arena has translational potential in depression, social stress, and anxiety─all of which have high relevance in aging─and may contribute to reducing social isolation and improving well-being of individuals across the lifespan.

  6. Current floristic and phytogeographic knowledge of Mexican Bromeliaceae

    Directory of Open Access Journals (Sweden)

    Adolfo Espejo Serna

    1998-09-01

    Full Text Available A current floristic and phytogeographic knowledge of native Mexican Bromeliaceae is presented. There are 22 genera of Bromeliaceae recorded from the country that include 326 species. The genus Ursulaea with 2 species is endemic to Mexico, while Hechtia with 48 of its 50 species has its principal center of diversity in the country. Tillandsia (175 spp, Hechtia (48 spp and Pitcairnia (46 spp are the genera with the greatest number of species. We present a comparative analysis of Mexican Bromeliaceae with that of other American regions that have recently published accounts for the Family, particularly the Mesomerican area, Venezuela, Ecuador, and the Guianas. Our results led us to the conclusion that all these floras should be considered as distinct. We observe a progressive decrease of the Simpson index value related with the remoteness of the Mexican area. A general analysis of the species numbers of Mexican bromeliad genera shows a distinct preference of the species for coniferous and oak forests, followed by tropical caducifolious forests. There is also significant representation of the family in other vegetation types such as cloud forests and tropical perennifolious forests. Generally Mexican Bromeliaceae species have scarce and sparse populations and in many cases they inhabit cliffs, bluffs and scarps in restricted areas. Concerning the geographic distribution of Mexican genera, 77.27 % are neotropical, 4.54% are South American and the remainder are Mexican and Central American. The generic endemism is very low (4.54 %, even if we extend the country limits to Megamexico sensu Rzedowsi (1991 it reaches only 13.63 %. The family endemism at specific level reaches 63.07 %. There are not available data about a specific analysis of the conservation status of Mexican Bromeliaceae, but we can point out that a great number of taxa are only known from the type collection or at the most from the type locality. This can perhaps be attributed in part to

  7. Current problems in Russian-Latvian relations

    Directory of Open Access Journals (Sweden)

    Mezhevich Nikolay

    2013-09-01

    Full Text Available Current relations between Russia and Latvia are still influenced by a series of mutual claims that appeared after the demise of the USSR. Latvia — as well as Estonia and Lithuania — is both an EU and NATO member state. However, unlike the above mentioned countries, its relations with Russia are developing at a more pragmatic level. Numerous political differences often result in economic losses both for Latvia and Russia. Despite the fact that Latvia has been an independent state for more than 20 years, there are still some unresolved issues in its relations with Russia. Today, relations between the two countries are often viewed through the prism of EU — Russia relations. Nonetheless, they often do not fit this context. Settling differences between Latvia and Russia will contribute to trade relations, which are increasingly important for both parties. In order to prevent and localise emerging conflicts, diplomats, politicians, and experts should interpret Russian-Latvian relations in view of the national features without referring to theoretical models based on the mythological “unity” of the three Baltic States.

  8. Knowledge Management in healthcare libraries: the current picture.

    Science.gov (United States)

    Hopkins, Emily

    2017-06-01

    Knowledge management has seen something of a resurgence in attention amongst health librarians recently. Of course it has never ceased to exist, but now many library staff are becoming more involved in organisational knowledge management, and positioning themselves as key players in the sphere. No single model of knowledge management is proliferating, but approaches that best fit the organisation's size, structure and culture, and a blending of evidence based practice and knowledge sharing. Whatever it is called and whatever models are used, it's clear that for librarians and information professionals, the importance of putting knowledge and evidence into practice, sharing knowledge well and capturing it effectively, are still what we will continue to do. © 2017 Health Libraries Group.

  9. Relational capital, new knowledge and innovative ideas

    NARCIS (Netherlands)

    T.J.M. Mom (Tom)

    2016-01-01

    markdownabstractOrganisational learning occurs when people engage in exploration activities – activities aimed at acquiring and using new knowledge, ideas and insights. Exploration, explains Tom Mom, associate professor of strategic entrepreneurship at RSM, ‘is about people and organisations

  10. oral health related behaviour, knowledge, attitudes and beliefs

    African Journals Online (AJOL)

    The findings of this study have shown that the participants had conducive oral health behavior, sufficient knowledge, positive attitude and held positive beliefs regarding dental treatments. ORAL HEALTH RELATED BEHAVIOUR, KNOWLEDGE, ATTITUDES. AND BELIEFS AMONG SECONDARY SCHOOL STUDENTS IN.

  11. Current state of knowledge about nutritional care of pregnant women

    Directory of Open Access Journals (Sweden)

    Luciana Barretto

    2014-12-01

    Full Text Available Pregnancy involves a significant anabolic activity that leads to increased nutritional needs relative to the preconception period. This paper aims to review the current understanding of the energy needs of macro and micronutrients during pregnancy as well as guidelines to address common gastrointestinal disorders during pregnancy, the issue of pica and anthropometric assessment to ensure an optimum weight gain. With the exception of iron, most of the nutrients needed by the pregnancy can be provided by a complete and balanced diet. Currently the scientific evidence shows that routine supplementation with iron and folic acid during pregnancy is a practice that prevents iron deficiency anemia, neural tube disorders and preterm births. Intermittent iron supplementation can also be an appropriated intervention. If the diet does not guarantee and adequate support, iodine, vitamin B12 and vitamin D supplements should also be necessaries. The anthropometric assessment by the pattern of weight gain should be present at each prenatal care visit to prevent maternal and fetal complications. In situations where the mother’s weight cannot be assessed, arm muscle circumference is possible to make an overall assessment as it correlates with maternal weight gain alternative. Measurements of biceps, triceps and subscapular skinfolds are another alternative that is useful to evaluate the fatty deposits and their location, in a complementary way to gain weight.

  12. Mucopolysaccharidosis type I: current knowledge on its pathophysiological mechanisms.

    Science.gov (United States)

    Campos, Derbis; Monaga, Madelyn

    2012-06-01

    Mucopolysaccharidosis type I is one of the most frequent lysosomal storage diseases. It has a high morbidity and mortality, causing in many cases severe neurological and somatic damage in the first years of life. Although the clinical phenotypes have been described for decades, and the enzymatic deficiency and many of the mutations that cause this disease are well known, the underlying pathophysiological mechanisms that lead to its development are not completely understood. In this review we describe and discuss the different pathogenic mechanisms currently proposed for this disease regarding its neurological damage. Deficiency in the lysosomal degradation of heparan sulfate and dermatan sulfate, as well as its primary accumulation, may disrupt a variety of physiological and biochemical processes: the intracellular and extracellular homeostasis of these macromolecules, the pathways related to gangliosides metabolism, mechanisms related to the activation of inflammation, receptor-mediated signaling, oxidative stress and permeability of the lysosomal membrane, as well as alterations in intracellular ionic homeostasis and the endosomal pathway. Many of the pathogenic mechanisms proposed for mucopolysaccharidosis type I are also present in other lysosomal storage diseases with neurological implications. Results from the use of methods that allow the analysis of multiple genes and proteins, in both patients and animal models, will shed light on the role of each of these mechanisms and their combination in the development of different phenotypes due to the same deficiency.

  13. Sport-related anxiety: current insights

    Directory of Open Access Journals (Sweden)

    Ford JL

    2017-10-01

    Full Text Available Jessica L Ford, Kenneth Ildefonso, Megan L Jones, Monna Arvinen-Barrow Department of Kinesiology, Integrative Health Care & Performance Unit, University of Wisconsin-Milwaukee, Milwaukee, WI, USA Abstract: To date, much research has been devoted to understanding how anxiety can affect sport performance, both in practice and in competitive settings. It is well known that sport has the potential for high levels of stress and anxiety, and that practicing and employing a range of psychological strategies can be beneficial in anxiety management. Equally, growing evidence also suggests that anxiety can play a role in sport injury prevention, occurrence, rehabilitation, and the return to sport process. The purpose of this paper is to provide current insights into sport-related anxiety. More specifically, it will provide the reader with definitions and theoretical conceptualizations of sport-related anxiety. This will be followed by making a case for considering the term "performance" to be broader than activities associated with sport-related performance in practice and competition, by including performance activities associated with sport injury prevention, rehabilitation, and the return to sport process. The paper will then highlight the importance of recognizing early signs and symptoms of anxiety, and the potential need for referral. Finally, the conclusions will emphasize the need for appropriate, client-specific, and practitioner competent care for athletes experiencing sport-related anxiety. Keywords: anxiety, sport, performance, injury, sport medicine professional, sport psychology, mental health

  14. Colostomy irrigation: current knowledge and practice of WOC nurses.

    Science.gov (United States)

    Cobb, Martha D; Grant, Marcia; Tallman, Nancy J; Wendel, Christopher S; Colwell, Janice; McCorkle, Ruth; Krouse, Robert S

    2015-01-01

    This study builds on the authors' previous studies that demonstrate that persons living with a colostomy who practice colostomy irrigation (CI) experience quality-of-life benefits. Studies also reveal that patients may not be taught about CI. The purpose of this study was to determine current knowledge, attitudes, and practices of WOC nurses on CI. The target population was ostomy nurses who were members of the Wound, Ostomy and Continence Nurse's Society. Nine hundred eighty-five nurses out of a possible pool of 4191 members responded, providing a response rate of 24%. Their average age was 53 years (range, 25-79 years). Respondents averaged 12 years' experience as a WOC nurse (range, 1-40 years) and 90% (n = 875) were certified. Participants practiced in a variety of settings, including acute and long-term care facilities, home health, and ambulatory clinics. They saw an average of 37 ± 60.5 (mean ± SD) ostomy patients per year (range, 0-1100). A 1-time online survey (SurveyMonkey) of members of the Wound, Ostomy and Continence Nurses (WOCN) Society was conducted. In addition to demographic and educational information, questions also included (1) CI advantages and disadvantages; (2) CI content routinely taught; (3) challenges in assisting patients to learn CI; and (4) where preparation was received for teaching this procedure. Nurses were asked whether they believe CI is evidence-based. More than half identified irrigation as an evidence-based practice (59%), but half indicated they do not routinely teach CI. Multiple factors correlated with nurses' decisions to teach CI, including years of experience (P = .03), specific CI education (P < .001), and considering the intervention evidence-based (P < .001). Factors influencing CI instruction are multifactorial; they include nurses' attitudes, experience base, education, medical indications, setting characteristics, and patient interest and physical abilities. Education on this procedure is urgently needed for

  15. [Current status of the knowledge on Moroccan anophelines (Diptera: Culicidae): systematic, geographical distribution and vectorial competence].

    Science.gov (United States)

    Faraj, C; Ouahabi, S; Adlaoui, E; Elaouad, R

    2010-10-01

    This bibliographical study, based on published works, ministry of Health Reports, exploitation of the database relative to the entomological surveillance conducted in the framework of the National Malaria Control Program, as well as unpublished results obtained within the framework of the European project "Emerging disease in a changing European environment", summarizes and completes with new data current knowledge on the systematics, the distribution and the vectorial competence of moroccan anophelines. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  16. Scaling relations for eddy current phenomena

    International Nuclear Information System (INIS)

    Dodd, C.V.; Deeds, W.E.

    1975-11-01

    Formulas are given for various electromagnetic quantities for coils in the presence of conductors, with the scaling parameters factored out so that small-scale model experiments can be related to large-scale apparatus. Particular emphasis is given to such quantities as eddy current heating, forces, power, and induced magnetic fields. For axially symmetric problems, closed-form integrals are available for the vector potential and all the other quantities obtainable from it. For unsymmetrical problems, a three-dimensional relaxation program can be used to obtain the vector potential and then the derivable quantities. Data on experimental measurements are given to verify the validity of the scaling laws for forces, inductances, and impedances. Indirectly these also support the validity of the scaling of the vector potential and all of the other quantities obtained from it

  17. YBCO SQUIDs with unconventional current phase relation

    International Nuclear Information System (INIS)

    Bauch, T.; Johansson, J.; Cedergren, K.; Lindstroem, T.; Lombardi, F.

    2007-01-01

    We have studied the dynamics of YBa 2 Cu 3 O 7-δ (YBCO) dc sperconducting quantum interference devices (SQUIDs) characterized by an unconventional Josephson current phase relation (CPR). We have focused on SQUID configurations with Josephson junctions where the lobe of the order parameter in one electrode is facing a node in the other electrode. This order parameter arrangement should enhance the appearance of a sin(2φ) term in the CPR. The response of the critical current of the dc SQUID, under the effect of an external magnetic field, has been measured in temperature, down to 20 mK. Our experimental data have been compared with numerical simulations of the SQUIDs dynamics by considering a CPR of a single junction of the form I(φ) = I I sin(φ) - I II sin(2φ) where I I and I II are, respectively, the first and second harmonic component. In our devices the values of the sin(2φ) term are such that the fundamental state of the SQUID is naturally double degenerate. This is of great relevance for applications of d-wave SQUIDs in quantum information processing

  18. Integrating Relational Reasoning and Knowledge Revision during Reading

    Science.gov (United States)

    Kendeou, Panayiota; Butterfuss, Reese; Van Boekel, Martin; O'Brien, Edward J.

    2017-01-01

    Our goal in this theoretical contribution is to connect research on knowledge revision and relational reasoning. To achieve this goal, first, we review the "knowledge revision components framework" (KReC) that provides an account of knowledge revision processes, specifically as they unfold during reading of texts. Second, we review a…

  19. Clinical knowledge management: an overview of current understanding.

    Science.gov (United States)

    Bali, Rajeev K; Dwivedi, Ashish

    2005-01-01

    This chapter outlines contributions to a workshop for ICMCC 2005. We details some of the central issues surrounding the incorporation of the Knowledge Management (KM) paradigm for the healthcare and clinical sectors. The complex nature of KM is discussed, together with some essential theories and some contemporary applications of the tools and techniques are presented.

  20. Enhancing Location-Related Hydrogeological Knowledge

    Directory of Open Access Journals (Sweden)

    Alexander Kmoch

    2018-03-01

    Full Text Available We analyzed the corpus of three geoscientific journals to investigate if there are enough locational references in research articles to apply a geographical search method, such as the example of New Zealand. Based on all available abstracts and all freely available papers of the “New Zealand Journal of Geology and Geophysics”, the “New Zealand Journal of Marine and Freshwater Research”, and the “Journal of Hydrology, New Zealand”, we searched title, abstracts, and full texts for place name occurrences that match records from the official Land Information New Zealand (LINZ gazetteer. We generated ISO standard compliant metadata records for each article including the spatial references and made them available in a public catalogue service. This catalogue can be queried for articles based on authors, titles, keywords, topics, and spatial reference. We visualize the results in a map to show which area the research articles are about, and how much and how densely geographic space is described through these geoscientific research articles by mapping mentioned place names by their geographic locations. We outlined the methodology and technical framework for the geo-referencing of the journal articles and the platform design for this knowledge inventory. The results indicate that the use of well-crafted abstracts for journal articles with carefully chosen place names of relevance for the article provides a guideline for geographically referencing unstructured information like journal articles and reports in order to make such resources discoverable through geographical queries. Lastly, this approach can actively support integrated holistic assessment of water resources and support decision making.

  1. [Work related stress: from knowledge to practice].

    Science.gov (United States)

    Costa, G

    2009-01-01

    Work-related stress is a well documented condition, resulting from a distorted interaction between working conditions and individual coping resources, that may have a negative impact on workers' health and well-being, as well as nd on performance efficiency and productivity: hence high costs for workers companies and society. It is a complex multifaceted and multidimensional phenomenon, whose assessment needs a multidisciplinary approach (work management, psychology, physiology, ergonomics, sociology, medicine). That is why risk assessment and management require a careful analysis of work organization (i.e. working time, work load, autonomy, environment, human relations) and individual aspects (i.e. demography, personality, attitudes, motivation, coping strategies). The consequent actions, targeted to the individuals, groups and organizations, should be aimed at preventing or reducing work-related stress, on the one hand, and supporting and protecting the worker, on the other, considering cost/effectiveness and risk/benefit ratios. This can be achieveds to be done with the participation and close collaboration of all the social actors involved (employers, employees, technicians, work organization and occupational health experts), according to the European Framework Agreement on Work-related Stress, signed on October 2004 and included into the Italian Law Decree 81/2008.

  2. Racial disparities in smoking knowledge among current smokers: data from the health information national trends surveys.

    Science.gov (United States)

    Reimer, Rachel Ann; Gerrard, Meg; Gibbons, Frederick X

    2010-10-01

    Although African-Americans (Blacks) smoke fewer cigarettes per day than European-Americans (Whites), there is ample evidence that Blacks are more susceptible to smoking-related health consequences. A variety of behavioural, social and biological factors have been linked to this increased risk. There has been little research, however, on racial differences in smoking-related knowledge and perceived risk of lung cancer. The primary goal of the current study was to evaluate beliefs and knowledge that contribute to race disparities in lung cancer risk among current smokers. Data from two separate nationally representative surveys (the Health Information National Trends surveys 2003 and 2005) were analysed. Logistic and hierarchical regressions were conducted; gender, age, education level, annual household income and amount of smoking were included as covariates. In both studies, Black smokers were significantly more likely to endorse inaccurate statements than were White smokers, and did not estimate their lung cancer risk to be significantly higher than Whites. Results highlight an important racial disparity in public health knowledge among current smokers.

  3. Nuclear Power Reactor Core Melt Accidents. Current State of Knowledge

    International Nuclear Information System (INIS)

    Bentaib, Ahmed; Bonneville, Herve; Clement, Bernard; Cranga, Michel; Fichot, Florian; Koundy, Vincent; Meignen, Renaud; Corenwinder, Francois; Leteinturier, Denis; Monroig, Frederique; Nahas, Georges; Pichereau, Frederique; Van-Dorsselaere, Jean-Pierre; Cenerino, Gerard; Jacquemain, Didier; Raimond, Emmanuel; Ducros, Gerard; Journeau, Christophe; Magallon, Daniel; Seiler, Jean-Marie; Tourniaire, Bruno

    2013-01-01

    For over thirty years, IPSN and subsequently IRSN has played a major international role in the field of nuclear power reactor core melt accidents through the undertaking of important experimental programmes (the most significant being the Phebus- FP programme), the development of validated simulation tools (the ASTEC code that is today the leading European tool for modelling severe accidents), and the coordination of the SARNET (Severe Accident Research Network) international network of excellence. These accidents are described as 'severe accidents' because they can lead to radioactive releases outside the plant concerned, with serious consequences for the general public and for the environment. This book compiles the sum of the knowledge acquired on this subject and summarises the lessons that have been learnt from severe accidents around the world for the prevention and reduction of the consequences of such accidents, without addressing those from the Fukushima accident, where knowledge of events is still evolving. The knowledge accumulated by the Institute on these subjects enabled it to play an active role in informing public authorities, the media and the public when this accident occurred, and continues to do so to this day

  4. Agora: A proposal to overcome the limitations of the current knowledge creation process

    OpenAIRE

    ScientistFive

    2015-01-01

    Agora: A proposal to overcome the limitations of the current knowledge creation process ======================================================================================= By Scientistsfive () Abstract: The knowledge creation process is broken and can be improved by a combination of currently emerging tools. The rationale for this proposal is the notion that the current scientific process is not optimal: * Artificially staged competitions (g...

  5. Endodontic Microbiology and Pathobiology: Current State of Knowledge.

    Science.gov (United States)

    Fouad, Ashraf F

    2017-01-01

    Newer research tools and basic science knowledge base have allowed the exploration of endodontic diseases in the pulp and periapical tissues in novel ways. The use of next generation sequencing, bioinformatics analyses, genome-wide association studies, to name just a few of these innovations, has allowed the identification of hundreds of microorganisms and of host response factors. This review addresses recent advances in endodontic microbiology and the host response and discusses the potential for future innovations in this area. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Piping and erosion in buffer and backfill materials. Current knowledge

    International Nuclear Information System (INIS)

    Boergesson, Lennart; Sanden, Torbjoern

    2006-09-01

    The water inflow into the deposition holes and tunnels in a repository will mainly take place through fractures in the rock and will lead to that the buffer and backfill will be wetted and homogenised. But in general the buffer and backfill cannot absorb all water that runs through a fracture, which leads to that a water pressure will be generated in the fracture when the inflow is hindered. If the counter pressure and strength of the buffer or backfill is insufficiently high, piping and subsequent erosion may take place. The processes and consequences of piping and erosion have been studied in some projects and several laboratory test series in different scales have been carried through. This brief report describes these tests and the results and conclusions that have emerged. The knowledge of piping and erosion is insufficient today and additional studies are needed and running

  7. A survey of university students' vitamin D-related knowledge.

    Science.gov (United States)

    Boland, Shaunessey; Irwin, Jennifer D; Johnson, Andrew M

    2015-01-01

    To survey Canadian university students' vitamin D-related knowledge. Undergraduate university students (n = 1,088) were surveyed as to their vitamin D-related knowledge, including its sources, health benefits, and recommended intake. Overall, students answered 29% of questions correctly on the knowledge test. In addition, the overall test was subdivided into 3 subtests, and students scored 26% on vitamin D source knowledge, 23% on factors affecting vitamin D levels, and 37% on health effects of vitamin D. Only 8% of participants correctly identified the recommended vitamin D intake; 14% correctly identified the amount of time in the sun required to produce adequate vitamin D. These results suggest that Canadian university students have poor knowledge concerning vitamin D. Program planners should consider improving vitamin D knowledge as a component of future health promotion programs for university students. Copyright © 2015 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

  8. Arrhythmogenic KCNE gene variants: current knowledge and future challenges

    Directory of Open Access Journals (Sweden)

    Shawn M Crump

    2014-01-01

    Full Text Available There are twenty-five known inherited cardiac arrhythmia susceptibility genes, all of which encode either ion channel pore-forming subunits or proteins that regulate aspects of ion channel biology such as function, trafficking and localization. The human KCNE gene family comprises five potassium channel regulatory subunits, sequence variants in each of which are associated with cardiac arrhythmias. KCNE gene products exhibit promiscuous partnering and in some cases ubiquitous expression, hampering efforts to unequivocally correlate each gene to specific native potassium currents. Likewise, deducing the molecular etiology of cardiac arrhythmias in individuals harboring rare KCNE gene variants, or more common KCNE polymorphisms, can be challenging. In this review we provide an update on putative arrhythmia-causing KCNE gene variants, and discuss current thinking and future challenges in the study of molecular mechanisms of KCNE-associated cardiac rhythm disturbances.

  9. Assessment of knowledge and awareness among radiology personnel regarding current computed tomography technology and radiation dose

    Science.gov (United States)

    Karim, M. K. A.; Hashim, S.; Bradley, D. A.; Bahruddin, N. A.; Ang, W. C.; Salehhon, N.

    2016-03-01

    In this paper, we evaluate the level of knowledge and awareness among 120 radiology personnel working in 7 public hospitals in Johor, Malaysia, concerning Computed Tomography (CT) technology and radiation doses based on a set of questionnaires. Subjects were divided into two groups (Medical profession (Med, n=32) and Allied health profession (AH, n=88). The questionnaires are addressed: (1) demographic data (2) relative radiation dose and (3) knowledge of current CT technology. One-third of respondents from both groups were able to estimate relative radiation dose for routine CT examinations. 68% of the allied health profession personnel knew of the Malaysia regulations entitled ‘Basic Safety Standard (BSS) 2010’, although notably 80% of them had previously attended a radiation protection course. No significant difference (p < 0.05) in mean scores of CT technology knowledge detected between the two groups, with the medical professions producing a mean score of (26.7 ± 2.7) and the allied health professions a mean score of (25.2 ± 4.3). This study points to considerable variation among the respondents concerning their understanding of knowledge and awareness of risks of radiation and CT optimization techniques.

  10. Assessment of knowledge and awareness among radiology personnel regarding current computed tomography technology and radiation dose

    International Nuclear Information System (INIS)

    Karim, M K A; Hashim, S; Bahruddin, N A; Ang, W C; Salehhon, N; Bradley, D A

    2016-01-01

    In this paper, we evaluate the level of knowledge and awareness among 120 radiology personnel working in 7 public hospitals in Johor, Malaysia, concerning Computed Tomography (CT) technology and radiation doses based on a set of questionnaires. Subjects were divided into two groups (Medical profession (Med, n=32) and Allied health profession (AH, n=88). The questionnaires are addressed: (1) demographic data (2) relative radiation dose and (3) knowledge of current CT technology. One-third of respondents from both groups were able to estimate relative radiation dose for routine CT examinations. 68% of the allied health profession personnel knew of the Malaysia regulations entitled ‘Basic Safety Standard (BSS) 2010’, although notably 80% of them had previously attended a radiation protection course. No significant difference (p < 0.05) in mean scores of CT technology knowledge detected between the two groups, with the medical professions producing a mean score of (26.7 ± 2.7) and the allied health professions a mean score of (25.2 ± 4.3). This study points to considerable variation among the respondents concerning their understanding of knowledge and awareness of risks of radiation and CT optimization techniques. (paper)

  11. Pain in Neurodegenerative Disease : Current Knowledge and Future Perspectives

    NARCIS (Netherlands)

    de Tommaso, Marina; Arendt-Nielsen, Lars; Defrin, Ruth; Kunz, Miriam; Pickering, Gisele; Valeriani, Massimiliano

    2016-01-01

    Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD),

  12. How does relativity affect magnetically induced currents?

    Science.gov (United States)

    Berger, R J F; Repisky, M; Komorovsky, S

    2015-09-21

    Magnetically induced probability currents in molecules are studied in relativistic theory. Spin-orbit coupling (SOC) enhances the curvature and gives rise to a previously unobserved current cusp in AuH or small bulge-like distortions in HgH2 at the proton positions. The origin of this curvature is magnetically induced spin-density arising from SOC in the relativistic description.

  13. Current knowledge on diabetic retinopathy from humandonor tissues

    Institute of Scientific and Technical Information of China (English)

    Jessica H Eisma; Jennifer E Dulle; Patrice E Fort

    2015-01-01

    According to the American Diabetes Association, diabetes was the seventh leading cause of death, and diabetic retinopathy the leading cause of blindness in working age adults in the United States in 2010. Diabetes is characterized by hyperglycemia associated with either hypoinsulinemia or insulin resistance, and over time, this chronic metabolic condition may lead to various complications including kidney failure, heart attacks,and retinal degeneration. In order to better understandthe molecular basis of this disease and its complications,animal models have been the primary approach usedto investigate the effects of diabetes on various tissuesor cell types of the body, including the retina. However,inherent to these animal models are critical limitationsthat make the insight gained from these modelschallenging to apply to the human pathology. Thesedifficulties in translating the knowledge obtained fromanimal studies have led a growing number of researchgroups to explore the diabetes complications, especiallydiabetic retinopathy, on tissues from human donors.This review summarizes the data collected from diabeticpatients at various stages of diabetic retinopathy andclassifies the data based upon their relevance to themain aspects of diabetic retinopathy: retinal vasculaturedysfunction, inflammation, and neurodegeneration. Thisreview discusses the importance of those studies todiscriminate and establish the relevance of the findingsobtained from animal models but also the limitations ofsuch approaches.

  14. Current knowledge on biodegradable microspheres in drug delivery.

    Science.gov (United States)

    Prajapati, Vipul D; Jani, Girish K; Kapadia, Jinita R

    2015-08-01

    Biodegradable microspheres have gained popularity for delivering a wide variety of molecules via various routes. These types of products have been prepared using various natural and synthetic biodegradable polymers through suitable techniques for desired delivery of various challenging molecules. Selection of biodegradable polymers and technique play a key role in desired drug delivery. This review describes an overview of the fundamental knowledge and status of biodegradable microspheres in effective delivery of various molecules via desired routes with consideration of outlines of various compendial and non-compendial biodegradable polymers, formulation techniques and release mechanism of microspheres, patents and commercial biodegradable microspheres. There are various advantages of using biodegradable polymers including promise of development with different types of molecules. Biocompatibility, low dosage and reduced side effects are some reasons why usage biodegradable microspheres have gained in popularity. Selection of biodegradable polymers and formulation techniques to create microspheres is the biggest challenge in research. In the near future, biodegradable microspheres will become the eco-friendly product for drug delivery of various genes, hormones, proteins and peptides at specific site of body for desired periods of time.

  15. Framework for product knowledge and product related knowledge which supports product modelling for mass customization

    DEFF Research Database (Denmark)

    Riis, Jesper; Hansen, Benjamin Loer; Hvam, Lars

    2003-01-01

    on experience from product modelling projects in several companies. Among them for example companies manufacturing electronic switchboards, spray dryer systems and air conditioning equipment. The framework is divided into three views: the product knowledge view, the life phase system view and the transformation...... and personalization. The framework for product knowledge and product related knowledge is based on the following theories: axiomatic design, technical systems, theory of domains, theory of structuring, theory of properties and the framework for the content of product and product related models. The framework is built......The article presents a framework for product knowledge and product related knowledge which can be used to support the product modelling process which is needed for developing IT systems. These IT systems are important tools for many companies when they aim at achieving mass customization...

  16. Logical knowledge representation of regulatory relations in biomedical pathways

    DEFF Research Database (Denmark)

    Zambach, Sine; Hansen, Jens Ulrik

    2010-01-01

    Knowledge on regulatory relations, in for example regulatory pathways in biology, is used widely in experiment design by biomedical researchers and in systems biology. The knowledge has typically either been represented through simple graphs or through very expressive differential equation...... simulations of smaller parts of a pathway. In this work we suggest a knowledge representation of the most basic relations in regulatory processes regulates, positively regulates and negatively regulates in logics based on a semantic analysis. We discuss the usage of these relations in biology and in articial...... intelligence for hypothesis development in drug discovery....

  17. Air travel and radiation risks - review of current knowledge

    International Nuclear Information System (INIS)

    Zeeb, H.; Blettner, M.

    2004-01-01

    Aircrew and passengers are exposed to cosmic radiation, in particular when travelling routes close to the poles and in high altitudes. The paper reviews current radiation measurement and estimation approaches as well as the actual level of cosmic radiation that personnel and travellers receive and summarizes the available epidemiological evidence on health effects of cosmic radiation. On average, German aircrew is exposed to les than 5 mSv per annum, and even frequent travellers only rarely reach values above 1 mSv/year. Cohort studies among aircrew have found very little evidence for an increased incidence or mortality of radiation-associated cancers. Only malignant melanoma rates have consistently found to be increased among male aircrew. Socioeconomic and reproductive aspects are likely to contribute to the slightly elevated breast cancer risk of female aircrew. Cytogenetic studies have not yielded consistent results. Based on these data overall risk increases for cancer among occupationally exposed aircrew appear unlikely. This also applies to air travellers who are usually exposed to much lower radiation levels. Occasional air travel during pregnancy does not pose a significant radiation risk, but further considerations apply in this situation. The currently available studies are limited with regard to methodological issues and case numbers so that a continuation of cohort studies in several European countries is being planned. (orig.) [de

  18. Association between Hepatitis B-Related Knowledge and Health ...

    African Journals Online (AJOL)

    Purpose: To evaluate the association between patient's knowledge of Hepatitis-B and Health Related Quality of Life (HRQoL). Methods: A cross sectional, descriptive study was undertaken with 390 hepatitis-B patients attending two public hospitals in Quetta City, Pakistan. Knowledge of hepatitis-B was assessed using a ...

  19. an assessment of knowledge of farming-related hazards

    African Journals Online (AJOL)

    Tersor

    knowledge and practices of farm related occupational hazards in the study area. ... JOURNAL OF RESEARCH IN FORESTRY, WILDLIFE AND ENVIRONMENT VOLUME 7, No.2 SEPTEMBER, ... the farmers will increase efficiency by 21 percent. ... knowledge acquisition is that people are born ..... Operational Habits and.

  20. Watch: Current knowledge of the terrestrial Global Water Cycle"

    NARCIS (Netherlands)

    Harding, R.; Best, M.; Hagemann, S.; Kabat, P.; Tallaksen, L.M.; Warnaars, T.; Wiberg, D.; Weedon, G.P.; Lanen, van H.A.J.; Ludwig, F.; Haddeland, I.

    2011-01-01

    Water-related impacts are among the most important consequences of increasing greenhouse gas concentrations. Changes in the global water cycle will also impact the carbon and nutrient cycles and vegetation patterns. There is already some evidence of increasing severity of floods and droughts and

  1. Cyberbullying Prevention and Intervention Efforts: Current Knowledge and Future Directions

    Science.gov (United States)

    Hong, Jun Sung

    2016-01-01

    Bullying is a serious public health concern that is associated with significant negative mental, social, and physical outcomes. Technological advances have increased adolescents’ use of social media, and online communication platforms have exposed adolescents to another mode of bullying—cyberbullying. Prevention and intervention materials, from websites and tip sheets to classroom curriculum, have been developed to help youth, parents, and teachers address cyberbullying. While youth and parents are willing to disclose their experiences with bullying to their health care providers, these disclosures need to be taken seriously and handled in a caring manner. Health care providers need to include questions about bullying on intake forms to encourage these disclosures. The aim of this article is to examine the current status of cyberbullying prevention and intervention. Research support for several school-based intervention programs is summarised. Recommendations for future research are provided. PMID:28562094

  2. Cyberbullying Prevention and Intervention Efforts: Current Knowledge and Future Directions.

    Science.gov (United States)

    Espelage, Dorothy L; Hong, Jun Sung

    2017-06-01

    Bullying is a serious public health concern that is associated with significant negative mental, social, and physical outcomes. Technological advances have increased adolescents' use of social media, and online communication platforms have exposed adolescents to another mode of bullying- cyberbullying. Prevention and intervention materials, from websites and tip sheets to classroom curriculum, have been developed to help youth, parents, and teachers address cyberbullying. While youth and parents are willing to disclose their experiences with bullying to their health care providers, these disclosures need to be taken seriously and handled in a caring manner. Health care providers need to include questions about bullying on intake forms to encourage these disclosures. The aim of this article is to examine the current status of cyberbullying prevention and intervention. Research support for several school-based intervention programs is summarised. Recommendations for future research are provided.

  3. Anterior point of reference: Current knowledge and perspectives in prosthodontics

    Directory of Open Access Journals (Sweden)

    Prince Kumar

    2012-01-01

    Full Text Available The opening and closing mandibular axis is not a purely theoretical postulation, but an absolutely demonstrable biomechanical entity. It is very crucial to accurately record and transfer to articulators for the purpose of maxillofacial rehabilitation. Following the Face bow record and transfer of the mandibular axis to an anatomic articulator, we can then mount the casts so that they open and close on the articulator in the same fashion as the patient′s jaws. For this reason one of the fixed factors presented by the patient is taken into the consideration, which if properly considered, can be of inestimable value in all phases of dental treatment. This paper has sought to review the current concepts and practical implications regarding anterior point of reference in prosthodontics.

  4. Facilitation of Function and Manipulation Knowledge of Tools Using Transcranial Direct Current Stimulation (tDCS

    Directory of Open Access Journals (Sweden)

    Ryo Ishibashi

    2018-01-01

    Full Text Available Using a variety of tools is a common and essential component of modern human life. Patients with brain damage or neurological disorders frequently have cognitive deficits in their recognition and manipulation of tools. In this study, we focused on improving tool-related cognition using transcranial direct current stimulation (tDCS. Converging evidence from neuropsychology, neuroimaging and non- invasive brain stimulation has identified the anterior temporal lobe (ATL and inferior parietal lobule (IPL as brain regions supporting action semantics. We observed enhanced performance in tool cognition with anodal tDCS over ATL and IPL in two cognitive tasks that require rapid access to semantic knowledge about the function or manipulation of common tools. ATL stimulation improved access to both function and manipulation knowledge of tools. The effect of IPL stimulation showed a trend toward better manipulation judgments. Our findings support previous studies of tool semantics and provide a novel approach for manipulation of underlying circuits.

  5. Disease-related knowledge, attitude and practices of tuberculosis ...

    African Journals Online (AJOL)

    Preferred Customer

    BACKGROUND: Tuberculosis (TB) is a major public health problem. World Health ... hospitals were interviewed on their knowledge, attitude and practice related to TB using pre-tested ..... patients exercise care to limit the spread of. TB, only ...

  6. Gulf War Syndrome: a review of current knowledge and understanding.

    Science.gov (United States)

    Minshall, D

    2014-01-01

    The 1991 Persian Gulf War was a resounding military success for coalition forces, who liberated Kuwait following the Iraqi invasion. The medical legacy we have from the conflict is the poorly understood, yet remarkable, phenomenon of Gulf War Syndrome, which surfaced soon after. Epidemiological research has proven beyond doubt that Gulf War veterans report a wide variety of symptoms, in excess of appropriately matched control subjects, and experience worse general health. Numerous toxic environmental hazards have been suggested as causes of Gulf War Syndrome, yet exhaustive scientific study has failed to provide conclusive proof of any link. No novel or recognised disease has been found to account for the symptomatic burden of veterans, and the optimal treatment remains uncertain. This understanding can be added to from an anthropological perspective, where the narratives of those afflicted provide further insight. The nature of military life was changing at the time of the Gulf War, challenging the identity and beliefs of some veterans and causing socio-cultural distress. The symptomatic presentation of Gulf War Syndrome can be considered an articulation of this disharmony. Gulf War Syndrome can also be considered within the group of post-combat disorders such as shellshock, the like of which have occurred after major wars in the last century. With the current withdrawal from Afghanistan, the Defence Medical Services (DMS) should heed the lessons of history.

  7. Are iron oxide nanoparticles safe? Current knowledge and future perspectives.

    Science.gov (United States)

    Valdiglesias, Vanessa; Fernández-Bertólez, Natalia; Kiliç, Gözde; Costa, Carla; Costa, Solange; Fraga, Sonia; Bessa, Maria Joao; Pásaro, Eduardo; Teixeira, João Paulo; Laffon, Blanca

    2016-12-01

    Due to their unique physicochemical properties, including superparamagnetism, iron oxide nanoparticles (ION) have a number of interesting applications, especially in the biomedical field, that make them one of the most fascinating nanomaterials. They are used as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Together with these valuable uses, concerns regarding the onset of unexpected adverse health effects following exposure have been also raised. Nevertheless, despite the numerous ION purposes being explored, currently available information on their potential toxicity is still scarce and controversial data have been reported. Although ION have traditionally been considered as biocompatible - mainly on the basis of viability tests results - influence of nanoparticle surface coating, size, or dose, and of other experimental factors such as treatment time or cell type, has been demonstrated to be important for ION in vitro toxicity manifestation. In vivo studies have shown distribution of ION to different tissues and organs, including brain after passing the blood-brain barrier; nevertheless results from acute toxicity, genotoxicity, immunotoxicity, neurotoxicity and reproductive toxicity investigations in different animal models do not provide a clear overview on ION safety yet, and epidemiological studies are almost inexistent. Much work has still to be done to fully understand how these nanomaterials interact with cellular systems and what, if any, potential adverse health consequences can derive from ION exposure. Copyright © 2016 Elsevier GmbH. All rights reserved.

  8. Aetiology of childhood acute leukaemias: Current status of knowledge

    International Nuclear Information System (INIS)

    Rossig, C.; Juergens, H.

    2008-01-01

    Acute leukaemia is a consequence of malignant transformation of a haematopoietic progenitor cell. Molecular studies have revealed a prenatal origin of many childhood leukaemias. According to current models, a pre-leukaemic stem cell clone is generated by a first mutation in utero which, in a minority of children, progresses to leukaemia after receiving further postnatal genetic hits. The nature of pre- and postnatal events involved in leukemogenesis in children is not well understood. Although genetic predisposition and specific environmental exposures may account for individual cases, the bulk of childhood leukaemia cannot be explained by any of these factors. The higher incidence of the most common leukaemia subtype in affluent societies, as well as the age peak between 2-5 y, suggest a contributory role of socioeconomic factors. An abnormal immune response during delayed exposure to common infections provides a plausible mechanism for malignant progression of pre-leukaemic clones in a subgroup of children. As highlighted in this review, a common cause for all types and subtypes of childhood leukaemia is highly unlikely. Deeper insights into the pathogenesis of childhood leukaemia will rely on large-scale and combined epidemiological and bio-molecular studies. (authors)

  9. Subclinical hypothyroidism in childhood - current knowledge and open issues.

    Science.gov (United States)

    Salerno, Mariacarolina; Capalbo, Donatella; Cerbone, Manuela; De Luca, Filippo

    2016-12-01

    Subclinical hypothyroidism is defined as serum levels of TSH above the upper limit of the reference range, in the presence of normal concentrations of total T 4 or free T 4 . This biochemical profile might be an indication of mild hypothyroidism, with a potential increased risk of metabolic abnormalities and cardiovascular disease recorded among adults. Whether subclinical hypothyroidism results in adverse health outcomes among children is a matter of debate and so management of this condition remains challenging. Mild forms of untreated subclinical hypothyroidism do not seem to be associated with impairments in growth, bone health or neurocognitive outcome. However, ongoing scientific investigations have highlighted the presence of subtle proatherogenic abnormalities among children with modest elevations in their TSH levels. Although current findings are insufficient to recommend levothyroxine treatment for all children with mild asymptomatic forms of subclinical hypothyroidism, they highlight the potential need for assessment of cardiovascular risk among children with this condition. Increased understanding of the early metabolic risk factors associated with subclinical hypothyroidism in childhood will help to improve the management of affected individuals.

  10. Current collective engagement stakeholder strategies for South African labour relations

    Directory of Open Access Journals (Sweden)

    Popi C. Madlala

    2018-05-01

    Full Text Available Orientation: Collective engagement stakeholder strategies are significant for the creation of harmony in the workplace. It is a known fact that the South African (SA labour environment has been dominated by industrial action before and after the 1994 democratic transition. To be precise, the statistics reveals that industrial action has increased and become more destructive post-1994. Purpose: The purpose of this article was to present the current collective engagement stakeholder strategies for South African labour relations. Motivation for the study: The SA mining sector has seen more violent strikes, with a higher number of deaths, injuries, criminal activities, arrests, dismissals and job losses in recent years. This article captures the current mining stakeholder strategies shaping the existing labour relations environment. Research approach, design and method: This is a theoretical article highlighting the recent literature on collective engagement in the mining sector in South Africa. Main findings: This article presents the current labour relations incidents, reflecting the need for more effective collective engagement and stakeholder management strategies. Practical and managerial implications: The current labour relations context has prompted key stakeholders at the National Economic Development and Labour Council (NEDLAC to look specifically at promoting employment, labour market stability, the right to strike, minimising violence through collective bargaining and highlighting the role of the state, reducing vulnerability through social protection and increasing the minimum wage. Contribution or value add: This article adds theoretically to the existing body of knowledge regarding collective engagement and stakeholder strategies in the SA mining sector.

  11. What stresses remote area nurses? Current knowledge and future action.

    Science.gov (United States)

    Lenthall, Sue; Wakerman, John; Opie, Tess; Dollard, Maureen; Dunn, Sandra; Knight, Sabina; Macleod, Martha; Watson, Colin

    2009-08-01

    Review and synthesise the literature identifying the stresses experienced by remote area nurses (RANs). Identify interventions implemented to address identified stresses. Explore the use of the job demands-resources (JD-R) model. A comprehensive literature review was conducted using the meta-databases Ovid and Informit. Remote Australian primary health care centres. The reported demands experienced by RANs can be grouped into four themes: (i) the remote context; (ii) workload and extended scope of practice; (iii) poor management; and (iv) violence in the workplace and community. In this high-demand, low-resource context, the JD-R model of occupational stress is particularly pertinent to examining occupational stress among RANs. The demands on RANs, such as the isolated geographical context, are immutable. However, there are key areas where resources can be enhanced to better meet the high level of need. These are: (i) adequate and appropriate education, training and orientation; (ii) appropriate funding of remote health services; and (iii) improved management practices and systems. There is a lack of empirical evidence relating to stresses experienced by RANs. The literature identifies some of the stresses experienced by RANs as unique to the remote context, while some are related to high demands coupled with a deficit of appropriate resources. Use of models, such as the JD-R model of occupational stress, might assist in identifying key areas where resources can be enhanced to better meet the high level of need and reduce RANs' levels of stress.

  12. Vitamin D in the light of current knowledge

    Directory of Open Access Journals (Sweden)

    Radlović Nedeljko

    2012-01-01

    Full Text Available Vitamin D, i.e. 1,25(OH 2D, is an essential factor, not only of homeostasis of calcium and phosphorus, but also of cell proliferation, differentiation and apoptosis, immune and hormonal regulation, as well as other body processes. Thus, its optimal presence in the body is of exceptional significance for health, both of children, as well as adults and elderly persons. Today, it is known that the lack of vitamin D, besides having negative effects on the skeleton and teeth, also contributes to the development of various malignancies, primarily of the large bowel, prostate and breasts, as well as of autoimmune and allergic diseases, diabetes mellitus type II, arterial hypertension and others. Considered from the biological aspect, physiological requirements in vitamin D are achieved by cutaneous synthesis from 7-dehydrocholesterol during sun exposure, while, except rarely, it is very scarce in food. Having in mind extensive evidence that sun exposure presents a high risk for the development of skin malignancies, primarily melanoma, it is clear that humans are deprived of the natural and basic source of vitamin D. In accordance, as well as based on numerous epidemiological studies showing the increase of diseases, in the basis of which vitamin D deficiency plays the important role, next led to the recommended dietary allowance of vitamin D, regardless of age. According to current attitudes, it is recommended that the daily dietary allowances of vitamin D. i.e. the quantity of oral intake that would safely cover the optimal body requirements should be 400 IU for ages 0-18 years, 600 IU for ages 19-70 years and 800 IU for persons aged over 70 years.

  13. Genome Writing: Current Progress and Related Applications

    Directory of Open Access Journals (Sweden)

    Yueqiang Wang

    2018-02-01

    Full Text Available The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field. Finally, we discuss current challenges and future prospects. Keywords: Synthetic biology, Genome writing, Genome editing, Bioethics, Biosafety

  14. Deuteron forward photodisintegration: meson currents and relativity

    International Nuclear Information System (INIS)

    Friar, J.L.

    1983-01-01

    The few-nucleon problem in nuclear physics and the few-electron problem in atomic physics are shown to possess similarities. Relativistic aspects of the latter are reviewed. The radiative decay of the 3 P 1 excited state of helium-like ions to the 1 S 0 ground state is shown to be a theoretical analogue of low-energy deuteron forward photodisintegration. Both have large relativistic components. The extended Siegert's theorem, which permits application of Siegert's technique to arbitrary photon wave lengths, is applied to both transitions. Physical arguments for the two processes are stressed, and the relevance of interaction currents is discussed. 28 references

  15. Hundred years of atrial fibrillation: Current knowledge and perspectives

    Directory of Open Access Journals (Sweden)

    Potpara Tatjana

    2010-01-01

    Full Text Available Atrial fibrillation (AF is the most common sustained arrhythmia in general population. AF in humans was first described in 1903. Gradually, it has been well appreciated that AF is not just an acceptable alternative for normal rhythm but rather a serious threat, related to increased mortality and cardiovascular morbidity. AF can precipitate or worsen pre-existing heart failure, may cause the development of tachycardiomyopathy and is an independent risk factor for thromboembolic events, most frequently stroke. It has long been believed that rhythm control is the best therapy for AF. Nowadays there is a clear scientific proof that rhythm control offers no benefit over frequency control, at least for older patients, even with advanced left ventricular dysfunction. However, optimal treatment for younger, highly symptomatic, otherwise healthy AF patients has not been designed. Available antiarrhythmics have considerable proarrhythmic potential or organ toxicity, and new safer drugs are under investigation. Nonpharmacological approaches, namely RF-catheter ablation, are rapidly developing. Prevention of thromboembolism is imperative, and new safer oral anticoagulants have been intensively investigated. Recent randomized studies (PIAF, RACE, STAF, AFFIRM, HOT-CAFE did not solve the issue of optimal arrhythmia treatment, but they emphasized the prevention of thromboembolism based on risk factors, and not on AF type, mainly because asymptomatic episodes of AF may not be clinically recognized.

  16. Neuroimaging and obesity: current knowledge and future directions

    Science.gov (United States)

    Carnell, S.; Gibson, C.; Benson, L.; Ochner, C. N.; Geliebter, A.

    2011-01-01

    Summary Neuroimaging is becoming increasingly common in obesity research as investigators try to understand the neurological underpinnings of appetite and body weight in humans. Positron emission tomography (PET), functional magnetic resonance imaging (fMRI) and magnetic resonance imaging (MRI) studies examining responses to food intake and food cues, dopamine function and brain volume in lean vs. obese individuals are now beginning to coalesce in identifying irregularities in a range of regions implicated in reward (e.g. striatum, orbitofrontal cortex, insula), emotion and memory (e.g. amygdala, hippocampus), homeostatic regulation of intake (e.g. hypothalamus), sensory and motor processing (e.g. insula, precentral gyrus), and cognitive control and attention (e.g. prefrontal cortex, cingulate). Studies of weight change in children and adolescents, and those at high genetic risk for obesity, promise to illuminate causal processes. Studies examining specific eating behaviours (e.g. external eating, emotional eating, dietary restraint) are teaching us about the distinct neural networks that drive components of appetite, and contribute to the phenotype of body weight. Finally, innovative investigations of appetite-related hormones, including studies of abnormalities (e.g. leptin deficiency) and interventions (e.g. leptin replacement, bariatric surgery), are shedding light on the interactive relationship between gut and brain. The dynamic distributed vulnerability model of eating behaviour in obesity that we propose has scientific and practical implications. PMID:21902800

  17. Equine-Facilitated Therapy and Trauma: Current Knowledge, Future Needs

    Directory of Open Access Journals (Sweden)

    Marlys Staudt

    2017-09-01

    Full Text Available Equine-facilitated therapy (EFT is a relatively new treatment for trauma and PTSD. EFT as well as animal assisted interventions in general have been introduced and implemented in mental health treatment for children and adults, though the research in support of these interventions has not kept up with practice. The purpose of this review is to examine the use of EFT for clients suffering from trauma/PTSD. Studies were included if PTSD/trauma was assessed and/or was measured as an outcome. A search of relevant databases resulted in nine peer-reviewed studies that met criteria. Studies are summarized and implications for future research are discussed. In general, findings suggest that EFT is a promising intervention for trauma/PTSD. Recommendations include a call for more research that includes veterans as well as for research that explicates the mechanisms by which EFT may be effective.      Key words: trauma, PTSD, equine, equine therapy

  18. HIV-related knowledge and attitudes among Indonesian prison officers.

    Science.gov (United States)

    Hinduan, Zahrotur R; Suherman, Harry; Pinxten, W J Lucas; Alisjahbana, Bachti; Hospers, Harm J

    2013-01-01

    Prison officers have a vital role in running a secure and healthy living environment for the inmates. The purpose of this article is to examine the relationship between HIV/AIDS-related knowledge and attitude towards inmates living with HIV among the officers in an Indonesian narcotics prison. A total of 93 officers from a narcotics prison in Bandung, Indonesia voluntarily participated in this cross-sectional study by completing a self-reported questionnaire. A Prior focus group discussion was also held among selected participants. Statistical data analyses indicate that all domains of HIV/AIDS-related knowledge, i.e. knowledge of HIV-transmission, general HIV/AIDS knowledge and knowledge of HIV-prevention, have substantial positive correlations with the prison officers' attitude towards inmates living with HIV. These results show that the more knowledgeable the officers are, the less likely they are to respond in an unfavourable manner to inmates living with HIV and vice versa. Despite the limited participants involved in this study, the knowledge gaps that are identified in this study should be the starting point for the development of educational interventions for prison officers. Sufficient educational programs and the latest materials need to be made available within the prison. Commitment from prison authorities as well as a proper policy are also needed. This study helped prison authorities to identify areas for knowledge development of the officers. Hopefully the positive attitude towards inmates living with HIV will be developed.

  19. The human gut microbiome: current knowledge, challenges, and future directions.

    Science.gov (United States)

    Dave, Maneesh; Higgins, Peter D; Middha, Sumit; Rioux, Kevin P

    2012-10-01

    The Human Genome Project was completed a decade ago, leaving a legacy of process, tools, and infrastructure now being turned to the study of the microbes that reside in and on the human body as determinants of health and disease, and has been branded "The Human Microbiome Project." Of the various niches under investigation, the human gut houses the most complex and abundant microbial community and is an arena for important host-microbial interactions that have both local and systemic impact. Initial studies of the human microbiome have been largely descriptive, a testing ground for innovative molecular techniques and new hypotheses. Methods for studying the microbiome have quickly evolved from low-resolution surveys of microbial community structure to high-definition description of composition, function, and ecology. Next-generation sequencing technologies combined with advanced bioinformatics place us at the doorstep of revolutionary insight into the composition, capability, and activity of the human intestinal microbiome. Renewed efforts to cultivate previously "uncultivable" microbes will be important to the overall understanding of gut ecology. There remain numerous methodological challenges to the effective study and understanding of the gut microbiome, largely relating to study design, sample collection, and the number of predictor variables. Strategic collaboration of clinicians, microbiologists, molecular biologists, computational scientists, and bioinformaticians is the ideal paradigm for success in this field. Meaningful interpretation of the gut microbiome requires that host genetic and environmental influences be controlled or accounted for. Understanding the gut microbiome in healthy humans is a foundation for discovering its influence in various important gastrointestinal and nutritional diseases (eg, inflammatory bowel disease, diabetes, and obesity), and for rational translation to human health gains. Copyright © 2012 Mosby, Inc. All rights

  20. Current NRC activities related to MQA

    Energy Technology Data Exchange (ETDEWEB)

    Trottier, C.A.; Nellis, D.O. [Nuclear Regulatory Commission, Washington, DC (United States)

    1993-12-31

    The U.S. Nuclear Regulatory Commission`s (NRC`s) interest in measurement quality assurance (MQA) goes back to before 1963, when the Atomic Energy Commission (AEC) published a notice in the Federal Register concerning the need for establishing a Film Dosimetry Calibration Laboratory, and also provided a set of minimum performance criteria to be used by the laboratory in evaluating film dosimetry services used by licensees. The proposed laboratory was not established, but in 1967 the AEC contracted with Battelle`s Pacific Northwest Laboratory (PNL) to evaluate film dosimeter performance criteria and provide a basis for establishing a Film Dosimetry Calibration Laboratory if the study showed that it was needed. Then, in 1973, the Conference of Radiation Control Program Directors (CRCPD), concerned with the state of dosimetry processing and the lack of adequate standards, recommended that the National Bureau of Standards (NBS) direct a performance testing program for personnel dosimetry processing services. Later, in 1976, NRC asked PNL to conduct a study to evaluate the four existing performance standards for personnel dosimetry processing. One result of this study was that the HPSSC standard, which later became ANSI N13.11, was recommended as the standard for use in a national dosimetry processing program. The rest is common knowledge. With the support of numerous other federal agencies and the CRCPD, NRC published a regulation, effective in 1988, that required all processors of personnel dosimeters be accredited under the National Voluntary Laboratory Accreditation Program (NVLAP), operated by the NBS, which is now called the National Institute of Standards and Technology (NIST). At present, there are 75 dosimetry processing laboratories accredited under NVLAP. NRC has also been involved in extremity dosimeters, health physics survey instruments, bioassay measurements, electronic personnel dosimeters, and environmental monitoring around nuclear power plants.

  1. Current status in Japan related to LMNPP

    International Nuclear Information System (INIS)

    Otsuka, Takehiro

    1998-01-01

    Current status of nuclear power plants in Japan is presented with the basic concepts against ageing of LWR plants which are considered to continue growing into the 21st century. Life management for aged NPPs is recognized to be important for the safe and reliable operation. In April 1996 MITI published the first report regarding the measures to cope with the aged NPPs. Two BWRs and one PWR were evaluated as aged NPPs in Phase-I Technical evaluation, which concluded that safe operation is possible with correct and adequate maintenance despite operation exceeded 30 years. The technology development items towards attaining further highly reliable management were indicated including the inspection/monitoring technology, the preventive maintenance/repair technology and ageing evaluation technology

  2. Current Knowledge on Moderate Malnutrition in Sri Lanka

    International Nuclear Information System (INIS)

    Fernando, Peter Hiram Prasantha

    2014-01-01

    forms of under nutrition; stunting, wasting and underweight. A study conducted in 2006 in the central part of the country in the estate sector 46% acutely malnourished, 43% chronically malnourished and 32.9% both acutely and chronically malnourished. Although there were differences between boys and girls those differences were not statistically significant. Another study indicated the prevalence of protein energy malnutrition, underweight and wasting in State operated foster care institutions were considerably higher than the national levels (2006). No significant associations were there in relation to the studied sociodemographic characteristics with the under nutritional status of children brought up at ‘day-care centers’ or at home groups (2009). Selected aspects of infant complementary feeding practice in a district of Sri Lanka and outcome of an intervention aimed at improving these practices (2006) Since overweight and obesity has attracted the interest of the researchers’ under-nutrition has become a topic of yesteryear. Therefore it is important to revitalize research studies on moderate malnutrition in children. (author)

  3. Power relations and reciprocity: dialectics of knowledge construction.

    Science.gov (United States)

    Ben-Ari, Adital; Enosh, Guy

    2013-03-01

    In this article we suggest a theoretical framework of knowledge construction by employing the concept of dialectics to power relationships between researcher and participants. Power distribution in research is perceived as dichotomous and asymmetrical in favor of the researcher, creating unequal power relations that make exploitation possible. Acknowledging such exploitation has led to a critical stance and attempts to bridge gaps through egalitarianism and empowerment of participants. Some scholars have focused on shifting expert knowledge differentials between researcher and participants throughout the research project. Others have evaluated such gaps as a source of knowledge construction. In the present work we applied a dialectical approach to understanding research relationships, suggesting reciprocity as their defining attribute, regardless of symmetry or asymmetry and as a source of knowledge construction. In this article we recommend avoiding a taken-for-granted attitude, because we see it as a direct obstacle to the construction of knowledge.

  4. Current knowledge of soft cheeses flavor and related compounds.

    Science.gov (United States)

    Sablé, S; Cottenceau, G

    1999-12-01

    Cheese aroma is the result of the perception of a large number of molecules belonging to different chemical classes. The volatile compounds involved in the soft cheese flavor have received a great deal of attention. However, there has been less work concerning the volatile compounds in the soft smear-ripened cheeses than in the mold-ripened cheeses. This paper reviews the components that contribute to the characteristic flavor in the soft cheeses such as surface-ripened, Camembert-type, and Blue cheeses. The sensory properties and quantities of the molecules in the different cheeses are discussed.

  5. Awareness, Knowledge, and Concern about Age-Related Macular Degeneration

    Science.gov (United States)

    Cimarolli, Verena R.; Laban-Baker, Allie; Hamilton, Wanda S.; Stuen, Cynthia

    2012-01-01

    Age-related macular degeneration (AMD)--a common eye disease causing vision loss--can be detected early through regular eye-health examinations, and measures can be taken to prevent visual decline. Getting eye examinations requires certain levels of awareness, knowledge, and concern related to AMD. However, little is known about AMD-related…

  6. The relationship between chiropractor required and current level of business knowledge.

    Science.gov (United States)

    Ciolfi, Michael Anthony; Kasen, Patsy Anne

    2017-01-01

    Chiropractors frequently practice within health care systems requiring the business acumen of an entrepreneur. However, some chiropractors do not know the relationship between the level of business knowledge required for practice success and their current level of business knowledge. The purpose of this quantitative study was to examine the relationship between chiropractors' perceived level of business knowledge required and their perceived level of current business knowledge. Two hundred and seventy-four participants completed an online survey (Health Care Training and Education Needs Survey) which included eight key business items. Participants rated the level of perceived business knowledge required (Part I) and their current perceived level of knowledge (Part II) for the same eight items. Data was collected from November 27, 2013 to December 18, 2013. Data were analyzed using Spearman's ranked correlation to determine the statistically significant relationships for the perceived level of knowledge required and the perceived current level of knowledge for each of the paired eight items from Parts I and II of the survey. Wilcoxon Signed Ranks Tests were performed to determine the statistical difference between the paired items. The results of Spearman's correlation testing indicated a statistically significant ( p business items (6 of 8) however a statistically difference was demonstrated in only three of the paired business items. The implications of this study for social change include the potential to improve chiropractors' business knowledge and skills, enable practice success, enhance health services delivery and positively influence the profession as a viable career.

  7. HIV-related neuropathy: current perspectives

    Directory of Open Access Journals (Sweden)

    Schütz SG

    2013-09-01

    Full Text Available Sonja G Schütz, Jessica Robinson-Papp Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA Abstract: Distal symmetric polyneuropathy (DSP related to human immunodeficiency virus (HIV is one of the most common neurologic complications of HIV, possibly affecting as many as 50% of all individuals infected with HIV. Two potentially neurotoxic mechanisms have been proposed to play a crucial role in the pathogenesis of HIV DSP: neurotoxicity resulting from the virus and its products; as well as adverse neurotoxic effects of medications used in the treatment of HIV. Clinically, HIV DSP is characterized by a combination of signs and symptoms that include decreased deep tendon reflexes at the ankles and decreased sensation in the distal extremities as well as paresthesias, dysesthesias, and pain in a symmetric stocking–glove distribution. These symptoms are generally static or slowly progressive over time, and depending on the severity, may interfere significantly with the patient's daily activities. In addition to the clinical picture, nerve conduction studies and skin biopsies are often pursued to support the diagnosis of HIV DSP. Anticonvulsants, antidepressants, topical agents, and nonspecific analgesics may help relieve neuropathic pain. Specifically, gabapentin, lamotrigine, pregabalin, amitriptyline, duloxetine, and high-dose topical capsaicin patches have been used in research and clinical practice. Further research is needed to elucidate the pathogenesis of HIV DSP, thus facilitating the development of novel treatment strategies. This review discusses the epidemiology, pathophysiology, clinical findings, diagnosis, and management of DSP in the setting of HIV. Keywords: neuropathy, human immunodeficiency virus, acquired immunodeficiency syndrome, AIDS, distal symmetric polyneuropathy, DSP, pain

  8. Nonadherence is Associated with Lack of HIV-Related Knowledge

    DEFF Research Database (Denmark)

    Dyrehave, Charlotte; Rasmussen, Dlama Nggida; Hønge, Bo Langhoff

    2016-01-01

    -sectional study included 494 HIV-infected individuals from the Bissau HIV Cohort in Guinea-Bissau. They completed a questionnaire designed for assessment of adherence and HIV-related knowledge. RESULTS: A majority were female, 41% were illiterate, 25% did not take the medicine during the last 4 days, and 23......BACKGROUND: Poor treatment adherence is a main barrier for effective antiretroviral therapy (ART) globally. HIV-related knowledge may affect understanding and utilization of HIV medical information, hence limited health literacy is a known barrier to treatment adherence. DESIGN AND METHODS: A cross......% skipped their medicine during weekends. The most frequent reasons for not taking medicine were simply forgetting, side effects, lack of food, and being too ill to attend the clinic. Nonadherent patients had a lower level of HIV-related knowledge. CONCLUSION: Main barriers for nonadherence were side...

  9. Error-related negativities during spelling judgments expose orthographic knowledge.

    Science.gov (United States)

    Harris, Lindsay N; Perfetti, Charles A; Rickles, Benjamin

    2014-02-01

    In two experiments, we demonstrate that error-related negativities (ERNs) recorded during spelling decisions can expose individual differences in lexical knowledge. The first experiment found that the ERN was elicited during spelling decisions and that its magnitude was correlated with independent measures of subjects' spelling knowledge. In the second experiment, we manipulated the phonology of misspelled stimuli and observed that ERN magnitudes were larger when misspelled words altered the phonology of their correctly spelled counterparts than when they preserved it. Thus, when an error is made in a decision about spelling, the brain processes indexed by the ERN reflect both phonological and orthographic input to the decision process. In both experiments, ERN effect sizes were correlated with assessments of lexical knowledge and reading, including offline spelling ability and spelling-mediated vocabulary knowledge. These results affirm the interdependent nature of orthographic, semantic, and phonological knowledge components while showing that spelling knowledge uniquely influences the ERN during spelling decisions. Finally, the study demonstrates the value of ERNs in exposing individual differences in lexical knowledge. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes

    KAUST Repository

    Wilson, S. K.; Adjeroud, M.; Bellwood, D. R.; Berumen, Michael L.; Booth, D.; Bozec, Y.-M.; Chabanet, P.; Cheal, A.; Cinner, J.; Depczynski, M.; Feary, D. A.; Gagliano, M.; Graham, N. A. J.; Halford, A. R.; Halpern, B. S.; Harborne, A. R.; Hoey, A. S.; Holbrook, S. J.; Jones, G. P.; Kulbiki, M.; Letourneur, Y.; De Loma, T. L.; McClanahan, T.; McCormick, M. I.; Meekan, M. G.; Mumby, P. J.; Munday, P. L.; Ohman, M. C.; Pratchett, M. S.; Riegl, B.; Sano, M.; Schmitt, R. J.; Syms, C.

    2010-01-01

    Expert opinion was canvassed to identify crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes. Scientists that had published three or more papers on the effects of climate and environmental factors on reef

  11. Current knowledge on the genetics of autism and propositions for future research.

    Science.gov (United States)

    Bourgeron, Thomas

    2016-01-01

    Autism spectrum disorders (ASD) are a heterogeneous group of neuropsychiatric disorders characterized by problems in social communication, as well as by the presence of restricted interests, stereotyped and repetitive behaviours. In the last 40years, genetic studies have provided crucial information on the causes of ASD and its diversity. In this article, I will first review the current knowledge on the genetics of ASD and then suggest three propositions to foster research in this field. Twin and familial studies estimated the heritability of ASD to be 50%. While most of the inherited part of ASD is captured by common variants, our current knowledge on the genetics of ASD comes almost exclusively from the identification of highly penetrant de novo mutations through candidate gene or whole exome/genome sequencing studies. Approximately 10% of patients with ASD, especially those with intellectual disability, are carriers of de novo copy-number (CNV) or single nucleotide variants (SNV) affecting clinically relevant genes for ASD. Given the function of these genes, it was hypothesized that abnormal synaptic plasticity and failure of neuronal/synaptic homeostasis could increase the risk of ASD. In addition to these discoveries, three propositions coming from institutions, researchers and/or communities of patients and families can be made to foster research on ASD: (i) to use more dimensional and quantitative data than diagnostic categories; (ii) to increase data sharing and research on genetic and brain diversity in human populations; (iii) to involve patients and relatives as participants for research. Hopefully, this knowledge will lead to a better diagnosis, care and integration of individuals with ASD. Copyright © 2016 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  12. Relational dynamics in the multi-helices knowledge production system

    DEFF Research Database (Denmark)

    Thai, Thi Minh; Hjortsø, Carsten Nico Portefée

    -level dynamics are characterized by political ambidexterity that enables the state to maintain control by privileging traditional science and education constituencies, and at the same time support the transition of the knowledge production system towards international methodology and quality standards through......Drawing on the triple helix framework and organizational institutionalism, this article applies a qualitative research approach to analyze structures, institutional logics, power relations that shape inter-organizational relations and the structuration of a knowledge production system...... in an emerging economy. Findings highlight the emergence of a fifth-helices knowledge production system includes the state, science and education, industry, international actors, and society. The system comprises two major segments, one associated with the traditional command economy and characterized...

  13. Crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes

    KAUST Repository

    Wilson, S. K.

    2010-02-26

    Expert opinion was canvassed to identify crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes. Scientists that had published three or more papers on the effects of climate and environmental factors on reef fishes were invited to submit five questions that, if addressed, would improve our understanding of climate change effects on coral reef fishes. Thirty-three scientists provided 155 questions, and 32 scientists scored these questions in terms of: (i) identifying a knowledge gap, (ii) achievability, (iii) applicability to a broad spectrum of species and reef habitats, and (iv) priority. Forty-two per cent of the questions related to habitat associations and community dynamics of fish, reflecting the established effects and immediate concern relating to climate-induced coral loss and habitat degradation. However, there were also questions on fish demographics, physiology, behaviour and management, all of which could be potentially affected by climate change. Irrespective of their individual expertise and background, scientists scored questions from different topics similarly, suggesting limited bias and recognition of a need for greater interdisciplinary and collaborative research. Presented here are the 53 highest-scoring unique questions. These questions should act as a guide for future research, providing a basis for better assessment and management of climate change impacts on coral reefs and associated fish communities.

  14. Heart of the FCS Body of Knowledge: Relational Ethic

    Science.gov (United States)

    Roubanis, Jody L.

    2016-01-01

    The Family and Consumer Sciences Body of Knowledge (FCS-BOK) provides an ideological stance that is universal to all practitioners of the profession, and it has major implications for the normative ethics that guide professional practice. The purpose of this article is to outline a conceptual framework to reveal the relational ethic inherent in…

  15. HIV/AIDS - related knowledge, attitudes and practices among South ...

    African Journals Online (AJOL)

    Objectives. To assess the level of HlV-related knowledge, as well as high-risk behaviour and attitudes towards HIV, in a group of South African National Defence Force (SANDF) recruits. Design. Cross-sectional study. Setting. Tempe military base in Bloemfontein. Subjects. Three hundred and thirty-nine recruits from one ...

  16. HIV/AIDS Related Knowledge and Perceived Risk Associated with ...

    African Journals Online (AJOL)

    Using data from the 2004 National Survey of Adolescents in Uganda, logistic regression models were fitted to examine the odds that HIV/AIDS related knowledge and perceived risk of HIV infection are associated with condom use among adolescents. After including demographic measures, findings indicated that correct ...

  17. Health-related knowledge and behaviour of primary school children ...

    African Journals Online (AJOL)

    There is a serious need for children to be informed about the negative influence of unhealthy living which has become part and parcel of the post-industrial contemporary society. The aim of this study was to investigate the health-related knowledge and behaviour of senior primary school children in the Honeydew area, and ...

  18. Traditional forest-related knowledge and climate change

    Science.gov (United States)

    John A. Parrotta; Mauro Agnoletti

    2012-01-01

    The holders and users of traditional forest-related knowledge are on the front lines of global efforts to deal with climate change and its impacts. Because of their close connection with, and high dependence on, forest ecosystems and landscapes, indigenous and local communities are among the fi rst to witness, understand, and experience the impacts of climate change on...

  19. Existing knowledge related to mainstreaming IKS into Educational ...

    African Journals Online (AJOL)

    The study aimed at determining existing knowledge related to mainstreaming of IKS into education system. The qualitative research methodology was appropriate for this study to explore and describe the mainstreaming of IKS into the existing education system. The study included 10 school teachers (5male and 5 females) ...

  20. Knowledge, experience & attitudes concerning electroconvulsive therapy among patients & their relatives

    OpenAIRE

    Rajagopal, R.; Chakrabarti, S.; Grover, S.; Khehra, N.

    2012-01-01

    Background & objectives: Electroconvulsive therapy (ECT) is used frequently in developing countries, but investigations of patients’ awareness and perception of ECT are rare. The present study thus attempted a comprehensive examination of knowledge, experience and attitudes concerning ECT among patients treated with brief-pulse, bilateral, modified ECT, and their relatives. Methods: Of the 153 recipients of ECT, 77 patients and relatives were eventually assessed using questionnaires designed ...

  1. On the Relationships between (Relatively) Advanced Mathematical Knowledge and (Relatively) Advanced Problem-Solving Behaviours

    Science.gov (United States)

    Koichu, Boris

    2010-01-01

    This article discusses an issue of inserting mathematical knowledge within the problem-solving processes. Relatively advanced mathematical knowledge is defined in terms of "three mathematical worlds"; relatively advanced problem-solving behaviours are defined in terms of taxonomies of "proof schemes" and "heuristic behaviours". The relationships…

  2. Pediatrician Knowledge, Attitudes, and Practice Related to Electronic Cigarettes.

    Science.gov (United States)

    Gorzkowski, Julie A; Whitmore, Regina M; Kaseeska, Kristen R; Brishke, Janet K; Klein, Jonathan D

    2016-07-01

    Electronic cigarettes (e-cigarettes) have grown rapidly in popularity, creating concerns for pediatricians and families. Evaluating pediatricians' understanding of e-cigarettes is an important first step in effectively addressing these products in practice. This qualitative study assesses pediatricians' knowledge, attitudes, and current clinical practices related to e-cigarettes. We conducted six focus groups with 37 pediatric clinicians in 2014. Groups were led by a trained facilitator using a semistructured discussion guide. Responses were recorded, transcribed, and coded to identify relevant themes. Pediatricians know that e-cigarettes generally contain nicotine and that adolescents and young adults are most likely to use them. However, most feel uninformed about the health effects of e-cigarettes and report wanting scientific evidence for safety or harm from credible sources. Pediatricians are skeptical of claims that e-cigarettes are safe, either for users or for those exposed to second-hand e-cigarette vapor or emissions. Participants noted that clinical conversations about e-cigarettes were rare, citing barriers including a lack of systematic screening, competing priorities during clinical visits, and, for some, limited confidence in their ability to address e-cigarettes during clinical encounters. No participants recommended e-cigarettes for cessation. Pediatricians feel poorly informed about e-cigarettes and are concerned about their potential health effects. While clinical discussions about e-cigarettes are rare, recent increases in their use leaves many clinicians wanting guidance about what to say to patients and families. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  3. Nurses’ Bedsore-Related Knowledge in Sanandaj Educational Healthcare Centers

    Directory of Open Access Journals (Sweden)

    Shadiyeh Kanani

    2017-10-01

    Full Text Available Background and Purpose A bed sore is a major problem in hospitalized patients, which can cost a lot for the patients, families, hospitals, health care institutions, and the community as a whole. On the other hand, one of the duties of the nursing staff is the care of the patient’s skin to prevent the formation of an ulcer. In addition, they are also responsible for providing the necessary measures to prevent the onset of pressure ulcers in the hospital. This critical role of nurses itself requires improving their knowledge regarding compression ulcers. The aim of this study was to determine the knowledge level of nurses in Sanandaj sanitary care centers, which was done in 2014 for bedsores. Methods This cross-sectional study was conducted in 2014 on 390 nurses from Sanandaj health centers that were selected by the census. Data were collected using the Piperfahr questionnaire. Data analysis was done using the SPSS software and necessary tests. Results The rate of correct answers related to the onset of bedsore with the highest frequency being 77.7% in the range of “good”, the bedsore evaluation with the frequency of 48.7% in the range of “average, and that of the bedsore-related knowledge with the highest correct answers of 94.6% in the range of “good”. There was a significant relationship (P 0.05. Conclusions The results showed that, with the highest frequency of correct answers (86.2%, the nursing knowledge is in an average level. Therefore, their level of knowledge can be promoted by additional relevant learning. Furthermore, the level of knowledge can have a positive effect on the performance.

  4. A relational data-knowledge base system and its potential in developing a distributed data-knowledge system

    Science.gov (United States)

    Rahimian, Eric N.; Graves, Sara J.

    1988-01-01

    A new approach used in constructing a rational data knowledge base system is described. The relational database is well suited for distribution due to its property of allowing data fragmentation and fragmentation transparency. An example is formulated of a simple relational data knowledge base which may be generalized for use in developing a relational distributed data knowledge base system. The efficiency and ease of application of such a data knowledge base management system is briefly discussed. Also discussed are the potentials of the developed model for sharing the data knowledge base as well as the possible areas of difficulty in implementing the relational data knowledge base management system.

  5. Parent Knowledge and Perceptions of Concussion Related to Youth Football.

    Science.gov (United States)

    Rieger, Brian; Lewandowski, Lawrence; Potts, Heather; Potter, Kyle; Chin, Lawrence S

    2018-03-04

    Introduction There is increased concern about concussion in youth athletes, yet there is little research on parent knowledge of concussion. Purpose  The purpose of the current study was to investigate attitudes to and knowledge of concussion among parents of youth football players. Methods We surveyed 180 parents/guardians of youth football players, ages 5-12, regarding their knowledge and beliefs concerning concussion. Results We found that the vast majority of respondents (86%) had confidence in their ability to recognize concussions. Yet, a significant number also held misconceptions about concussions, such as 'too much sleep' (48%) or 'eating certain foods' (26%) make concussion symptoms worse. Most (82%) had not heard of the Zurich guidelines, and less than half (44%) were aware that sustained mental activity could worsen symptoms. Parents were concerned about their child sustaining a concussion, but a substantial minority also reported 'serious concern' about their children losing playing time or their position.  Discussion Results are somewhat positive in terms of parents' general knowledge of concussions; yet, response variability and misconceptions point to a continued need for concussion education for parents. Medical professionals can play an important role in informing families about concussion symptoms, management, and recovery.

  6. What's Past Is Prologue: Relations between Early Mathematics Knowledge and High School Achievement

    Science.gov (United States)

    Watts, Tyler W.; Duncan, Greg J.; Siegler, Robert S.; Davis-Kean, Pamela E.

    2014-01-01

    Although previous research has established the association between early-grade mathematics knowledge and later mathematics achievement, few studies have measured mathematical skills prior to school entry, and few have investigated the predictive power of early gains in mathematics ability. The current paper relates mathematical skills measured at…

  7. Making the invisible, visible: challenging the knowledge structures inherent in International Relations Theory in order to create knowledge plural curricula

    Directory of Open Access Journals (Sweden)

    Jacqueline de Matos-Ala

    2018-02-01

    Full Text Available Abstract This article problematizes the lack of plurality of knowledges in International Relations theory curricula. The increase in knowledges and scholarship from the South has not seemingly filtered into International Relations theory curricula significantly. Thus Western knowledges still dominates the narrative. It investigates how knowledge structures inherent in the discipline coupled with Western centric ontology and epistemology function to exclude or marginalize knowledge that does not conform to specific criteria. I demonstrate how the third year IR theory curriculum at Wits University, has engaged with discipline’s knowledge structures as well as its ontology and epistemology to develop a knowledge plural curricula.

  8. Relative Price Levels and Current Accounts: An Exploration

    Directory of Open Access Journals (Sweden)

    Joshua Aizenman

    2008-12-01

    Full Text Available This paper studies the links between current accounts and relative price levels, finding that current account changes are associated with sizable future relative price levels effects. This is done in panel regressions of the Penn effect, adding a lagged current account/GDP and other explanatory variables. Higher GDP/ capita and a greater export share of manufacturing tend to mitigate the real exchange rate impact of lagged current accounts. Active management of current accounts may provide a powerful adjustment channel, mitigating the real exchange rate effects of volatile terms of trade, and may explain the growing proliferation of Sovereign Wealth Funds.

  9. The current state of knowledge on the use of the benchmark dose concept in risk assessment.

    Science.gov (United States)

    Sand, Salomon; Victorin, Katarina; Filipsson, Agneta Falk

    2008-05-01

    This review deals with the current state of knowledge on the use of the benchmark dose (BMD) concept in health risk assessment of chemicals. The BMD method is an alternative to the traditional no-observed-adverse-effect level (NOAEL) and has been presented as a methodological improvement in the field of risk assessment. The BMD method has mostly been employed in the USA but is presently given higher attention also in Europe. The review presents a number of arguments in favor of the BMD, relative to the NOAEL. In addition, it gives a detailed overview of the several procedures that have been suggested and applied for BMD analysis, for quantal as well as continuous data. For quantal data the BMD is generally defined as corresponding to an additional or extra risk of 5% or 10%. For continuous endpoints it is suggested that the BMD is defined as corresponding to a percentage change in response relative to background or relative to the dynamic range of response. Under such definitions, a 5% or 10% change can be considered as default. Besides how to define the BMD and its lower bound, the BMDL, the question of how to select the dose-response model to be used in the BMD and BMDL determination is highlighted. Issues of study design and comparison of dose-response curves and BMDs are also covered. Copyright (c) 2007 John Wiley & Sons, Ltd.

  10. Current knowledge of US metal and nonmetal miner health: Current and potential data sources for analysis of miner health status

    Science.gov (United States)

    Yeoman, K. M.; Halldin, C. N.; Wood, J.; Storey, E.; Johns, D.; Laney, A. S.

    2016-01-01

    ABSTRACT Little is known about the current health status of US metal and nonmetal (MNM) miners, in part because no health surveillance systems exist for this population. The National Institute for Occupational Safety and Health (NIOSH) is developing a program to characterize burden of disease among MNM miners. This report discusses current knowledge and potential data sources of MNM miner health. Recent national surveys were analyzed, and literature specific to MNM miner health status was reviewed. No robust estimates of disease prevalence were identified, and national surveys did not provide information specific to MNM miners. Because substantial gaps exist in the understanding of MNM miners' current health status, NIOSH plans to develop a health surveillance program for this population to guide intervention efforts to reduce occupational and personal risks for chronic illness. PMID:25658684

  11. [Oligometastasis in pancreatic cancer : Current state of knowledge and spectrum of local therapy].

    Science.gov (United States)

    Gebauer, F; Damanakis, A I; Bruns, C

    2018-03-20

    Several case series reported results of surgical resection in patients with pancreatic ductal adenocarcinoma in a metastasized stage. A summarized overview of the current state of knowledge and a summary of the results of currently available studies. A systematic search was carried out in MEDLINE and PubMed with respect to metastasized pancreatic cancer and surgical resection. The evidence level for surgical resection in the metastasized stage is weak and so far no prospective trials are available. The largest single-arm trial included 85 patients with hepatic metastasis. In cases of hepatic oligometastasis an overall survival of 11-14 months was observed. In the presence of pulmonary metastasis, overall survival seems to be prolonged compared to intra-abdominal metastasis, although the evidence level is relatively weak. According to the available results, a general recommendation for surgical resection in a metastasized stage cannot be given; however, the results show a possible benefit for some well-selected patient subgroups. Prospective trials must validate these data and investigate the use of combined surgical and systemic treatments in the case of resectable metastatic pancreatic cancer.

  12. Preschool-aged children’s understanding of gratitude: Relations with emotion and mental state knowledge

    Science.gov (United States)

    Nelson, Jackie A.; de Lucca Freitas, Lia Beatriz; O’Brien, Marion; Calkins, Susan D.; Leerkes, Esther M.; Marcovitch, Stuart

    2016-01-01

    Developmental precursors to children’s early understanding of gratitude were examined. A diverse group of 263 children were tested for emotion and mental state knowledge at ages 3 and 4, and their understanding of gratitude was measured at age 5. Children varied widely in their understanding of gratitude, but most understood some aspects of gratitude-eliciting situations. A model-building path analysis approach was used to examine longitudinal relations among early emotion and mental state knowledge and later understanding of gratitude. Children with a better early understanding of emotions and mental states understand more about gratitude. Mental state knowledge at age 4 mediated the relation between emotion knowledge at age 3 and gratitude understanding at age 5. The current study contributes to the scant literature on the early emergence of children’s understanding of gratitude. PMID:23331105

  13. Current-phase relations and noise in rf biased SQUIDS

    International Nuclear Information System (INIS)

    Jackel, L.D.; Clark, T.D.; Buhrman, R.A.

    1975-01-01

    An investigation was made of the effect of the weak link current-phase relation on noise in rf biased SQUIDs. Non-sinusoidal current-phase relations were observed in various weak links, and these non-sinusoidal relations were correlated with significantly increased intrinsic noise in the SQUID ring. The current-phase relation was also found to affect the amplitude of the rf SQUID ring dissipation. The result of an rf SQUID system noise analysis shows that, due to increased intrinsic noise and reduced ring dissipation, the minimum attainable noise for a SQUID ring having a very non-sinusoidal current-phase relation is considerably greater than for a ring with a sinusoidal relation

  14. Knowledge and practices related to reproductive health amongst adolescent girls

    Directory of Open Access Journals (Sweden)

    Jayashree S Gothankar

    2015-01-01

    Full Text Available Objective: To assess knowledge and practices related to menstruation and reproductive health amongst college going adolescent girls. Materials and Methods: Cross-sectional study done on 323 adolescent girls admitted in the year 2012 to professional colleges belonging to the health sciences faculty of a private university in Pune, India, using self-administered proforma. Results: Mean age of onset of menarche was 13.35 years. Many girls (86.65% had knowledge of menstruation prior to menarche. For 68% of girls, mother was a source of menstrual information. Half of the girls reported some form of restriction in activities during menstruation due to religious reasons. 11% girls suffered from some form of reproductive tract infections (RTIs. Practices related to menstruation revealed that cloth piece is used for menstrual protection by 3% of girls. Soaked sanitary pads were disposed sanitarily by 96% of girls. Adolescent of medical faculty had significantly more knowledge than nursing faculty adolescents regarding emergency contraceptives (P < 0.05. Only four girls reported a history of sexual contact, of these, three were aware of emergency contraceptives, while one used them to prevent pregnancy. Conclusions: Adolescent girls received knowledge of menstruation prior to menarche from their mothers. Restriction in activity during menstruation due to religious reasons is practiced by many girls. Sanitary pad was used by almost all girls, and all disposed the same in a sanitary manner. More than half of the girls were aware about emergency contraceptives. Prevalence of RTI was found to be low and very few girls reported history of sexual exposure.

  15. KNOWLEDGE AND SKILLS OF PROFESSIONALS IN INVESTOR RELATIONS

    Directory of Open Access Journals (Sweden)

    Andreja Hašček

    2017-01-01

    Full Text Available Management of investor relations is of utmost importance for a company that raises capital for its operations and projects in the capital market. Investor relations is a function through which the company develops investor confidence in the company and its business operations by establishing a continuous flow of information from the company to the investors on the basis of which investors can make an informed decision about investing in that company, and a flow of information from the investors to the company on the basis of which the company can draw conclusions on the requirements, needs and expectations of investors. Since this is an interdisciplinary function of the company, professionals with a broad range of knowledge and skills work in investor relations. This paper identifies the required knowledge and skills that are minimally required in order for a person in investor relations to be able to fulfil the basic task of this function, the purpose of which is to develop investor confidence in the company and its business operations in order to secure access to investor capital for the company.

  16. Current irritability robustly related to current and prior anxiety in bipolar disorder.

    Science.gov (United States)

    Yuen, Laura D; Miller, Shefali; Wang, Po W; Hooshmand, Farnaz; Holtzman, Jessica N; Goffin, Kathryn C; Shah, Saloni; Ketter, Terence A

    2016-08-01

    Although current irritability and current/prior anxiety have been associated in unipolar depression, these relationships are less well understood in bipolar disorder (BD). We investigated relationships between current irritability and current/prior anxiety as well as other current emotions and BD illness characteristics. Outpatients referred to the Stanford Bipolar Disorders Clinic during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation. Prevalence and clinical correlates of current irritability and current/prior anxiety and other illness characteristics were examined. Among 497 BD outpatients (239 Type I, 258 Type II; 58.1% female; mean ± SD age 35.6 ± 13.1 years), 301 (60.6%) had baseline current irritability. Patients with versus without current irritability had significantly higher rates of current anxiety (77.1% versus 42.9%, p anxiety disorder (73.1% versus 52.6%, p anxiety than to current anhedonia, sadness, or euphoria (all p anxiety associations persisted across current predominant mood states. Current irritability was more robustly related to past anxiety than to all other assessed illness characteristics, including 1° family history of mood disorder, history of alcohol/substance use disorder, bipolar subtype, and current syndromal/subsyndromal depression (all p anxiety. Further studies are warranted to assess longitudinal clinical implications of relationships between irritability and anxiety in BD. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Individual differences in current events knowledge: contributions of ability, personality, and interests.

    Science.gov (United States)

    Hambrick, David Z; Meinz, Elizabeth J; Oswald, Frederick L

    2007-03-01

    What accounts for individual differences in the sort of knowledge that people may draw on in everyday cognitive tasks, such as deciding whom to vote for in a presidential election, how to invest money in the stock market, or what team to bet on in a friendly wager? In a large sample of undergraduate students, we investigated correlates of individual differences in recently acquired knowledge of current events in domains such as politics, business, and sports. Structural equation modeling revealed two predictive pathways: one involving cognitive ability factors and the other involving two major nonability factors (personality and interests). The results of this study add to what is known about the sources of individual differences in knowledge and are interpreted in the context of theoretical conceptions of adult intelligence that emphasize the centrality and importance of knowledge (e.g., Ackerman, 1996; Cattell, 1971).

  18. 46 CFR 11.713 - Requirements for maintaining current knowledge of waters to be navigated.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Requirements for maintaining current knowledge of waters to be navigated. 11.713 Section 11.713 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Pilots § 11.713 Requirements for maintaining curren...

  19. Encouraging Civic Knowledge and Engagement: Exploring Current Events through a Psychological Lens

    Science.gov (United States)

    Van Camp, Debbie; Baugh, Stacey-Ann

    2016-01-01

    Engagement with political, social, and civil issues is a fundamental component of an educated population, but civic knowledge and engagement are decreasing among adolescents and young adults. A Psychology in Current Events class sought to increase this engagement and key skills such as critical thinking. A one-group pretest-posttest…

  20. Current Knowledge in lentil genomics and its application for crop improvement

    Directory of Open Access Journals (Sweden)

    Shiv eKumar

    2015-02-01

    Full Text Available Most of the lentil growing countries face a certain set of abiotic and biotic stresses causing substantial reduction in crop growth, yield, and production. Until-to date, lentil breeders have used conventional plant breeding techniques of selection-recombination-selection cycle to develop improved cultivars. These techniques have been successful in mainstreaming some of the easy-to-manage monogenic traits. However in case of complex quantitative traits, these conventional techniques are less precise. As most of the economic traits are complex, quantitative and often influenced by environments and genotype-environment (GE interaction, the genetic improvement of these traits becomes difficult. Genomics assisted breeding is relatively powerful and fast approach to develop high yielding varieties more suitable to adverse environmental conditions. New tools such as molecular markers and bioinformatics are expected to generate new knowledge and improve our understanding on the genetics of complex traits. In the past, the limited availability of genomic resources in lentil could not allow breeders to employ these tools in mainstream breeding program. The recent application of the Next Generation Sequencing (NGS and Genotyping by sequencing (GBS technologies has facilitated to speed up the lentil genome sequencing project and large discovery of genome-wide SNP markers. Recently, several linkage maps have been developed in lentil through the use of Expressed Sequenced Tag (EST-derived Simple Sequence Repeat (SSR and Single Nucleotide Polymorphism (SNP markers. These maps have emerged as useful genomic resources to identify QTL imparting tolerance to biotic and abiotic stresses in lentil. In this review, the current knowledge on available genomic resources and its application in lentil breeding program are discussed.

  1. The principle of relativity and the problem of knowledge

    International Nuclear Information System (INIS)

    Suarez Antola, R.

    2011-01-01

    This book can be considered as an introduction to some issues on the border between philosophy and science. It is intended for an audience interested in the problems that arise in scientific knowledge about the so-called post-modern era, and willing to study in some detail and depth the physical and mathematical foundations of the theory of relativity, and some of applications in astrophysics and cosmology. It assumes familiarity with the epistemology and other branches of philosophy. The philosophical content, including epistemological, are introduced as needed, starting with the first chapter is intended entirely to them, culminating in the fourteenth chapter, which discusses the structure of the theory of relativity, the theory general physics and cosmology from that point of view. In his chapters describes: the development of ideas in the Newtonian mechanics of particles and the classical theory of fields, including electromagnetism, the crisis in the foundations of nineteenth-century physics, the foundations, limitations and some applications of restricted theory, knowledge of mathematics, calculus of variations, foundations of general relativity theory, applications Schwartzschild solution, applications in astronomy and cosmology, relativistic physics issues and finally, aspects of scientific research work from the point of psychological and sociological

  2. Men's knowledge, attitudes and behaviours relating to fertility.

    Science.gov (United States)

    Hammarberg, Karin; Collins, Veronica; Holden, Carol; Young, Kate; McLachlan, Robert

    2017-07-01

    The increasingly common practice in high-income countries to delay childbearing to the fourth and fifth decades of life increases the risk of involuntary childlessness or having fewer children than desired. Older age also increases the risk of age-related infertility, the need for ART to conceive, and obstetric and neonatal complications. Existing research relating to childbearing focusses almost exclusively on women, and in public discourse declining fertility rates are often assumed to be the result of women delaying childbearing to pursue other life goals such as a career and travel. However, evidence suggests that the lack of a partner or a partner willing to commit to parenthood is the main reason for later childbearing. To better understand men's contributions to childbearing decisions and outcomes, the literature pertaining to men's fertility-related knowledge, attitudes and behaviours was reviewed. The electronic databases of Medline, Embase and PsycINFO were searched to identify investigations of men's knowledge, attitudes and behaviours relating to fertility, infertility, reproductive health or childbearing using relevant fertility keyword search terms. Studies were included if they had investigated factors associated with men's fertility-related knowledge, attitudes and behaviours, had been conducted in a high-income country and were published in an English language peer-reviewed journal between January 2005 and August 2016. The search yielded 1349 citations. Of these, 47 papers representing 43 unique studies were included in the review. Where response rate was reported, it ranged between 13 and 94%. Studies varied in terms of research design; inclusion and exclusion criteria; recruitment strategies; adequacy of sample size; recruitment and retention rates and data collection tools. However, findings were consistent and indicate that men almost universally value parenthood, want and expect to become fathers, and aspire to have at least two children. Yet

  3. Developing genomic knowledge bases and databases to support clinical management: current perspectives.

    Science.gov (United States)

    Huser, Vojtech; Sincan, Murat; Cimino, James J

    2014-01-01

    Personalized medicine, the ability to tailor diagnostic and treatment decisions for individual patients, is seen as the evolution of modern medicine. We characterize here the informatics resources available today or envisioned in the near future that can support clinical interpretation of genomic test results. We assume a clinical sequencing scenario (germline whole-exome sequencing) in which a clinical specialist, such as an endocrinologist, needs to tailor patient management decisions within his or her specialty (targeted findings) but relies on a genetic counselor to interpret off-target incidental findings. We characterize the genomic input data and list various types of knowledge bases that provide genomic knowledge for generating clinical decision support. We highlight the need for patient-level databases with detailed lifelong phenotype content in addition to genotype data and provide a list of recommendations for personalized medicine knowledge bases and databases. We conclude that no single knowledge base can currently support all aspects of personalized recommendations and that consolidation of several current resources into larger, more dynamic and collaborative knowledge bases may offer a future path forward.

  4. The effects of strontium on bone mineral: A review on current knowledge and microanalytical approaches.

    Science.gov (United States)

    Querido, William; Rossi, Andre L; Farina, Marcos

    2016-01-01

    The interest in effects of strontium (Sr) on bone has greatly increased in the last decade due to the development of the promising drug strontium ranelate. This drug is used for treating osteoporosis, a major bone disease affecting hundreds of millions of people worldwide, especially postmenopausal women. The novelty of strontium ranelate compared to other treatments for osteoporosis is its unique effect on bone: it simultaneously promotes bone formation by osteoblasts and inhibits bone resorption by osteoclasts. Besides affecting bone cells, treatment with strontium ranelate also has a direct effect on the mineralized bone matrix. Due to the chemical similarities between Sr and Ca, a topic that has long been of particular interest is the incorporation of Sr into bones replacing Ca from the mineral phase, which is composed by carbonated hydroxyapatite nanocrystals. Several groups have analyzed the mineral produced during treatment; however, most analysis were done with relatively large samples containing numerous nanocrystals, resulting thus on data that represents an average of many crystalline domains. The nanoscale analysis of the bone apatite crystals containing Sr has only been described in a few studies. In this study, we review the current knowledge on the effects of Sr on bone mineral and discuss the methodological approaches that have been used in the field. In particular, we focus on the great potential that advanced microscopy and microanalytical techniques may have on the detailed analysis of the nanostructure and composition of bone apatite nanocrystals produced during treatment with strontium ranelate. Copyright © 2015. Published by Elsevier Ltd.

  5. Power and momentum relations in rotating magnetic field current drive

    Energy Technology Data Exchange (ETDEWEB)

    Hugrass, W N [Flinders Univ. of South Australia, Bedford Park. School of Physical Sciences

    1984-01-01

    The use of rotating magnetic fields (RMF) to drive steady currents in plasmas involves a transfer of energy and angular momentum from the radio frequency source feeding the rotating field coils to the plasma. The power-torque relationships in RMF systems are discussed and the analogy between RMF current drive and the polyphase induction motor is explained. The general relationship between the energy and angular momentum transfer is utilized to calculate the efficiency of the RMF plasma current drive. It is found that relatively high efficiencies can be achieved in RMF current drive because of the low phase velocity and small slip between the rotating field and the electron fluid.

  6. Concussion As a Multi-Scale Complex System: An Interdisciplinary Synthesis of Current Knowledge

    Directory of Open Access Journals (Sweden)

    Erin S. Kenzie

    2017-09-01

    Full Text Available Traumatic brain injury (TBI has been called “the most complicated disease of the most complex organ of the body” and is an increasingly high-profile public health issue. Many patients report long-term impairments following even “mild” injuries, but reliable criteria for diagnosis and prognosis are lacking. Every clinical trial for TBI treatment to date has failed to demonstrate reliable and safe improvement in outcomes, and the existing body of literature is insufficient to support the creation of a new classification system. Concussion, or mild TBI, is a highly heterogeneous phenomenon, and numerous factors interact dynamically to influence an individual’s recovery trajectory. Many of the obstacles faced in research and clinical practice related to TBI and concussion, including observed heterogeneity, arguably stem from the complexity of the condition itself. To improve understanding of this complexity, we review the current state of research through the lens provided by the interdisciplinary field of systems science, which has been increasingly applied to biomedical issues. The review was conducted iteratively, through multiple phases of literature review, expert interviews, and systems diagramming and represents the first phase in an effort to develop systems models of concussion. The primary focus of this work was to examine concepts and ways of thinking about concussion that currently impede research design and block advancements in care of TBI. Results are presented in the form of a multi-scale conceptual framework intended to synthesize knowledge across disciplines, improve research design, and provide a broader, multi-scale model for understanding concussion pathophysiology, classification, and treatment.

  7. Key tasks in healthcare marketing: assessing importance and current level of knowledge.

    Science.gov (United States)

    Kennett, Pamela A; Henson, Steve W; Crow, Stephen M; Hartman, Sandra J

    2005-01-01

    When examining the healthcare industry, the need for continuing education in internal functions (i.e., HR management) has been documented. However, equally important to success in the healthcare industry are external functions such as marketing. In an expansion of research on internally focused functions, we report findings from an exploratory study designed to examine the perceptions of executives about managerial skill needs in the externally focused area of marketing. Specifically, we examine eight key tasks in marketing and ask executives to rate the level of knowledge required for each and then to assess current, or actual, levels of knowledge in the field. Findings suggest that pricing strategy, product strategy, and segmentation and targeting were the tasks that require the most knowledge for healthcare marketers, and that they do, in fact, perceive various gaps in all of the areas examined. Implications and suggestions for future research are provided.

  8. How is the Current Nano/Microscopic Knowledge Implemented in Model Approaches?

    International Nuclear Information System (INIS)

    Rotenberg, Benjamin

    2013-01-01

    The recent developments of experimental techniques have opened new opportunities and challenges for the modelling and simulation of clay materials, on various scales. In this communication, several aspects of the interaction between experimental and modelling approaches will be presented and dis-cussed. What levels of modelling are available depending on the target property and what experimental input is required? How can experimental information be used to validate models? What knowledge can modelling on different scale bring to the knowledge on the physical properties of clays? Finally, what can we do when experimental information is not available? Models implement the current nano/microscopic knowledge using experimental input, taking advantage of multi-scale approaches, and providing data or insights complementary to experiments. Future work will greatly benefit from the recent experimental developments, in particular for 3D-imaging on intermediate scales, and should also address other properties, e.g. mechanical or thermal properties. (authors)

  9. The Emergence of Knowledge and How it Supports the Memory for Novel Related Information.

    Science.gov (United States)

    Sommer, Tobias

    2017-03-01

    Current theories suggest that memories for novel information and events, over time and with repeated retrieval, lose the association to their initial learning context. They are consolidated into a more stable form and transformed into semantic knowledge, that is, semanticized. Novel, related information can then be rapidly integrated into such knowledge, leading to superior memory. We tested these hypotheses in a longitudinal, 302-day, human functional magnetic resonance imaging study in which participants first overlearned and consolidated associative structures. This phase was associated with a shift from hippocampal- to ventrolateral prefrontal cortex (vlPFC)-mediated retrieval, consistent with semanticization. Next, participants encoded novel, related information whose encoding into the already acquired knowledge was orchestrated by the ventromedial prefrontal cortex. Novel related information exhibited reduced forgetting compared with novel control information, which corresponded to a faster shift from hippocampal- to vlPFC-mediated retrieval. In sum, the current results suggest that memory for novel information can be enhanced by anchoring it to prior knowledge via acceleration of the processes observed during semanticization. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  10. What’s Past is Prologue: Relations Between Early Mathematics Knowledge and High School Achievement

    OpenAIRE

    Watts, Tyler W.; Duncan, Greg J.; Siegler, Robert S.; Davis-Kean, Pamela E.

    2014-01-01

    © 2014 AERA. Although previous research has established the association between early-grade mathematics knowledge and later mathematics achievement, few studies have measured mathematical skills prior to school entry, and few have investigated the predictive power of early gains in mathematics ability. The current paper relates mathematical skills measured at 54 months to adolescent mathematics achievement using multisite longitudinal data. We find that preschool mathematics ability predicts ...

  11. Analysis of the relation between knowledge engineering and knowledge management based on the Nonaka and Takeuchi models

    Directory of Open Access Journals (Sweden)

    Christian Reyes

    2007-07-01

    Full Text Available The use of the Knowledge Management is fundamental in the creation of value within the companies, being at the present time a new form to obtain competitive advantages in specific market. Also, for the process of value creation is necessary to use specifics Information Technologies that they allow to reach the objectives drawn up when implementing a Knowledge Management project. In this sense, one of the more complete and efficient Information Technologies is the Knowledge Based System that as well comprises of the Knowledge Engineering. This article tries to analyze the existing relation between Knowledge Management, a specific model of knowledge creation, the Knowledge Based System and how this Information Technologies play a very important role in the creation, codification and transference of knowledge.

  12. Knowledges

    DEFF Research Database (Denmark)

    Berling, Trine Villumsen

    2012-01-01

    Scientific knowledge in international relations has generally focused on an epistemological distinction between rationalism and reflectivism over the last 25 years. This chapter argues that this distinction has created a double distinction between theory/reality and theory/practice, which works...... and reflectivism. Bourdieu, on the contrary, lets the challenge to the theory/reality distinction spill over into a challenge to the theory/practice distinction by thrusting the scientist in the foreground as not just a factor (discourse/genre) but as an actor. In this way, studies of IR need to include a focus...... as a ghost distinction structuring IR research. While reflectivist studies have emphasised the impossibility of detached, objective knowledge production through a dissolution of the theory/reality distinction, the theory/practice distinction has been left largely untouched by both rationalism...

  13. Measurements of the reverse current of highly irradiated silicon sensors to determine the effective energy and current related damage rate

    Science.gov (United States)

    Wiehe, Moritz; Wonsak, S.; Kuehn, S.; Parzefall, U.; Casse, G.

    2018-01-01

    The reverse current of irradiated silicon sensors leads to self heating of the sensor and degrades the signal to noise ratio of a detector. Precise knowledge of the expected reverse current during detector operation is crucial for planning and running experiments in High Energy Physics. The dependence of the reverse current on sensor temperature and irradiation fluence is parametrized by the effective energy and the current related damage rate, respectively. In this study 18 n-in-p mini silicon strip sensors from companies Hamamatsu Photonics and Micron Semiconductor Ltd. were deployed. Measurements of the reverse current for different bias voltages were performed at temperatures of -32 ° C, -27 ° C and -23 ° C. The sensors were irradiated with reactor neutrons in Ljubljana to fluences ranging from 2 × 1014neq /cm2 to 2 × 1016neq /cm2. The measurements were performed directly after irradiation and after 10 and 30 days of room temperature annealing. The aim of the study presented in this paper is to investigate the reverse current of silicon sensors for high fluences of up to 2 × 1016neq /cm2 and compare the measurements to the parametrization models.

  14. Transitivity performance, relational hierarchy knowledge and awareness: results of an instructional framing manipulation.

    Science.gov (United States)

    Kumaran, Dharshan; Ludwig, Hans

    2013-12-01

    The transitive inference (TI) paradigm has been widely used to examine the role of the hippocampus in generalization. Here we consider a surprising feature of experimental findings in this task: the relatively poor transitivity performance and levels of hierarchy knowledge achieved by adult human subjects. We focused on the influence of the task instructions on participants' subsequent performance--a single-word framing manipulation which either specified the relation between items as transitive (i.e., OLD-FRAME: choose which item is "older") or left it ambiguous (i.e., NO-FRAME: choose which item is "correct"). We show a marked but highly specific effect of manipulating prior knowledge through instruction: transitivity performance and levels of relational hierarchy knowledge were enhanced, but premise performance unchanged. Further, we show that hierarchy recall accuracy, but not conventional awareness scores, was a significant predictor of inferential performance across the entire group of participants. The current study has four main implications: first, our findings establish the importance of the task instructions, and prior knowledge, in the TI paradigm--suggesting that they influence the size of the overall hypothesis space (e.g., to favor a linear hierarchical structure over other possibilities in the OLD-FRAME). Second, the dissociable effects of the instructional frame on premise and inference performance provide evidence for the operation of distinct underlying mechanisms (i.e., an associative mechanism vs. relational hierarchy knowledge). Third, our findings suggest that a detailed measurement of hierarchy recall accuracy may be a more sensitive index of relational hierarchy knowledge, than conventional awareness score--and should be used in future studies investigating links between awareness and inferential performance. Finally, our study motivates an experimental setting that ensures robust hierarchy learning across participants

  15. Managing player load in professional rugby union: a review of current knowledge and practices.

    Science.gov (United States)

    Quarrie, Kenneth L; Raftery, Martin; Blackie, Josh; Cook, Christian J; Fuller, Colin W; Gabbett, Tim J; Gray, Andrew J; Gill, Nicholas; Hennessy, Liam; Kemp, Simon; Lambert, Mike; Nichol, Rob; Mellalieu, Stephen D; Piscione, Julien; Stadelmann, Jörg; Tucker, Ross

    2017-03-01

    The loads to which professional rugby players are subjected has been identified as a concern by coaches, players and administrators. In November 2014, World Rugby commissioned an expert group to identify the physical demands and non-physical load issues associated with participation in professional rugby. To describe the current state of knowledge about the loads encountered by professional rugby players and the implications for their physical and mental health. The group defined 'load' as it relates to professional rugby players as the total stressors and demands applied to the players. In the 2013-2014 seasons, 40% of professional players appeared in 20 matches or more, and 5% of players appeared in 30 matches or more. Matches account for ∼5-11% of exposure to rugby-related activities (matches, team and individual training sessions) during professional competitions. The match injury rate is about 27 times higher than that in training. The working group surmised that players entering a new level of play, players with unresolved previous injuries, players who are relatively older and players who are subjected to rapid increases in load are probably at increased risk of injury. A mix of 'objective' and 'subjective' measures in conjunction with effective communication among team staff and between staff and players was held to be the best approach to monitoring and managing player loads. While comprehensive monitoring holds promise for individually addressing player loads, it brings with it ethical and legal responsibilities that rugby organisations need to address to ensure that players' personal information is adequately protected. Administrators, broadcasters, team owners, team staff and the players themselves have important roles in balancing the desire to have the 'best players' on the field with the ongoing health of players. In contrast, the coaching, fitness and medical staff exert significant control over the activities, duration and intensity of training

  16. Current programmes on physical metallurgy and related areas in BARC

    International Nuclear Information System (INIS)

    1994-01-01

    Current research and development programmes on physical metallurgy and related areas from the following Divisions of Bhabha Atomic Research Centre are included in this report : Atomic Fuels Division, High Pressure Physics Division, Metallurgy Division, Radio Metallurgy Division, Solid State Physics Division. Important publications corresponding to each activity have also been listed. (author)

  17. Transfer of managerial knowledge by business related services

    OpenAIRE

    Sjøholt, Peter

    2001-01-01

    The first part of the paper is a literature survey on learning in firms and organisations mainly through transnational transfer of knowledge. The discussion moves beyond "conventional economics" and puts the issue in a broader socio-cultural-geographic perspective. Various ways of organising transfer of knowledge are discussed: through formal and informal networks, from suppliers and customers and market oriented consultants. Different qualities or properties of knowledge will ...

  18. Public Knowledge about Hepatitis B-Related Issues in Korea

    Directory of Open Access Journals (Sweden)

    C Chrusch

    1996-01-01

    Full Text Available Hepatitis B infection is endemic in many parts of the world, including Korea. Basic knowledge of the hepatitis B virus by the public is a prerequisite for the development of a successful vaccination program. A survey was conducted in rural Korea to examine public knowledge of hepatitis B etiology, symptoms, transmission, risk factors and prevention. It was found that knowledge independently correlated with education and female sex, but that overall knowledge of hepatitis B was poor. The preferred information sources in order of preference were physicians, television and public health nurses. This information may be useful in designing public health education and vaccination programs in developing populations.

  19. Gender relations and health research: a review of current practices

    Directory of Open Access Journals (Sweden)

    Bottorff Joan L

    2011-12-01

    Full Text Available Abstract Introduction The importance of gender in understanding health practices and illness experiences is increasingly recognized, and key to this work is a better understanding of the application of gender relations. The influence of masculinities and femininities, and the interplay within and between them manifests within relations and interactions among couples, family members and peers to influence health behaviours and outcomes. Methods To explore how conceptualizations of gender relations have been integrated in health research a scoping review of the existing literature was conducted. The key terms gender relations, gender interactions, relations gender, partner communication, femininities and masculinities were used to search online databases. Results Through analysis of this literature we identified two main ways gender relations were integrated in health research: a as emergent findings; and b as a basis for research design. In the latter, gender relations are included in conceptual frameworks, guide data collection and are used to direct data analysis. Conclusions Current uses of gender relations are typically positioned within intimate heterosexual couples whereby single narratives (i.e., either men or women are used to explore the influence and/or impact of intimate partner gender relations on health and illness issues. Recommendations for advancing gender relations and health research are discussed. This research has the potential to reduce gender inequities in health.

  20. Knowledge Cities and Transport Sustainability: The Link between the Travel Behavior of Knowledge Workers and Car-Related Job Perks

    DEFF Research Database (Denmark)

    Frenkel, Amnon; Bendit, Edward; Kaplan, Sigal

    2014-01-01

    from a survey among knowledge workers in Tel-Aviv. Results show that car-related job perks are associated with (1) high annual kilometrage, (2) increased commute by car, (3) long commute travel times, (4) high trip chaining frequency, and (5) many long-distance leisure trips. Results suggest......This study analyzes the linkage between the travel behavior of knowledge workers and car-related job perks. The importance of this issue derives from the tendency of knowledge economy to concentrate in highly populated metropolitan regions. The analyzed data comprise 750 observations, retrieved...... that the development of sustainable knowledge-based cities should consider decoupling knowledge workers from car-related job perks. © 2014 Copyright Taylor and Francis Group, LLC....

  1. Current practice patterns and knowledge among gynecologic surgeons of InterStim® programming after implantation.

    Science.gov (United States)

    Hobson, Deslyn T G; Gaskins, Jeremy T; Frazier, LaTisha; Francis, Sean L; Kinman, Casey L; Meriwether, Kate V

    2017-10-03

    The objective of this study was to describe surgeons' current practices in InterStim® programming after initial implantation and their knowledge of programming parameters. We hypothesized that surgeons performing their own reprogramming would have increased knowledge. We administered a written survey to attendees at the Society of Gynecologic Surgeons Scientific Meeting and analyzed those on which surgeons indicated they offer InterStim® care. The survey queried surgeon characteristics, experience with InterStim® implantation and programming, and clinical opinions regarding reprogramming and tested six knowledge-based questions about programming parameters. Correct response to all six questions was the primary outcome. One hundred and thirty-five of 407 (33%) attendees returned the survey, of which 99 met inclusion criteria. Most respondents (88 of 99; 89%) were between 36 and 60 years, 27 (73%) were women, 76 (77%) practiced in a university setting, and 76 (77%) were trained in Female Pelvic Medicine and Reconstructive Surgery (FPMRS). Surgeons who had InterStim® programming training were more likely to perform their own programming [15/46 (32%) vs 6/47 (13%), p = 0.03]. Most answered all knowledge-based questions correctly (62/90, 69%); no surgeon characteristics were significantly associated with this outcome. Most surgeons cited patient comfort (71/80, 89%) and symptom relief (64/80, 80%) as important factors when reprogramming, but no prevalent themes emerged on how and why surgeons change certain programming parameters. Surgeons who had formal InterStim® programming training are more likely to perform programming themselves. No surgeon characteristic was associated with improved programming knowledge. We found that surgeons prioritize patient comfort and symptoms when deciding to reprogram.

  2. The aptness of knowledge related metaphors: a research agenda

    NARCIS (Netherlands)

    Dr. Daan Andriessen

    2010-01-01

    Metaphors are common phenomena intellectual capital and knowledge management theories and practice. An important question to ask is: what are the ‗best‘ metaphors we can use in our theorizing on intellectual capital and knowledge management? This paper addresses the question of the aptness of

  3. Introduction: The Growing Importance of Traditional Forest-Related Knowledge

    Science.gov (United States)

    Ronald L. Trosper; John A. Parrotta

    2012-01-01

    The knowledge, innovations, and practices of local and indigenous communities have supported their forest-based livelihoods for countless generations. The role of traditional knowledge—and the bio-cultural diversity it sustains—is increasingly recognized as important by decision makers, conservation and development organizations, and the scientifi c community. However...

  4. Atmospheric transport and deposition of pesticides: An assessment of current knowledge

    DEFF Research Database (Denmark)

    Pul, W.A.J. van; Bidleman, T.F.; Brorström-Lunden, E.

    1999-01-01

    The current knowledge on atmospheric transport and deposition of pesticides is reviewed and discussed by a working group of experts during the Workshop on Fate of pesticides in the atmosphere; implications for risk assessment, held in Driebergen, the Netherlands, 22-24 April, 1998. In general...... in the exchange processes at the interface between air and soil/water/vegetation. In all process descriptions the uncertainty in the physicochemical properties play an important role. Particularly those in the vapour pressure, Henry's law constant and its temperature dependency. More accurate data...

  5. Global forces and local currents in Argentina's science policy crossroads: restricted access or open knowledge

    Directory of Open Access Journals (Sweden)

    Horacio Javier Etchichury

    2014-11-01

    Full Text Available The article describes the tensions between two competing approaches to scientific policy in Argentina. The traditional vision favors autonomous research. The neoliberal conception fosters the link between science and markets. In the past few years, a neodevelopmentalist current also tries to stress relevance of scientific research. Finally, the article describes how the Open Access movement has entered the debate. The World Bank intervention and the human rights dimension of the question are discussed in depth. The article introduces the notion of open knowledge as a guiding criterion to design a human-rights based scientific policy.

  6. Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Breeman, W.A.P.; Jong, M. de; Kwekkeboom, D.J.; Valkema, R.; Bakker, W.H.; Kooij, P.P.M. [Dept. of Nuclear Medicine, Erasmus Medical Centre Rotterdam (Netherlands); Visser, T.J. [Dept. of Internal Medicine, Erasmus Medical Centre Rotterdam (Netherlands); Krenning, E.P. [Dept. of Nuclear Medicine, Erasmus Medical Centre Rotterdam (Netherlands); Dept. of Internal Medicine, Erasmus Medical Centre Rotterdam (Netherlands)

    2001-09-01

    In vivo somatostatin receptor-mediated scintigraphy has proven to be a valuable method for the visualisation of neuroendocrine tumours and their metastases. A new application is the use of radiolabelled analogues for somatostatin receptor-mediated therapy. This paper presents a review on the basic science, historical background and current knowledge of somatostatin receptor subtypes and their expression in neuroendocrine tumours. New somatostatin analogues, new chelators, ''new'' radionuclides and combinations thereof are also discussed. Due attention is given to limitations and future perspectives of somatostatin receptor-mediated imaging and therapy. (orig.)

  7. Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives

    International Nuclear Information System (INIS)

    Breeman, W.A.P.; Jong, M. de; Kwekkeboom, D.J.; Valkema, R.; Bakker, W.H.; Kooij, P.P.M.; Visser, T.J.; Krenning, E.P.

    2001-01-01

    In vivo somatostatin receptor-mediated scintigraphy has proven to be a valuable method for the visualisation of neuroendocrine tumours and their metastases. A new application is the use of radiolabelled analogues for somatostatin receptor-mediated therapy. This paper presents a review on the basic science, historical background and current knowledge of somatostatin receptor subtypes and their expression in neuroendocrine tumours. New somatostatin analogues, new chelators, ''new'' radionuclides and combinations thereof are also discussed. Due attention is given to limitations and future perspectives of somatostatin receptor-mediated imaging and therapy. (orig.)

  8. Sun-related knowledge and attitudes of primary and secondary schoolchildren in western Switzerland.

    Science.gov (United States)

    Vuadens, Anne; Ackermann, Simone; Levi, Fabio; Bulliard, Jean-Luc

    2017-09-01

    Switzerland, particularly its western region, has the highest incidence of melanoma in Europe. Although the risk of melanoma increases with sun overexposure during childhood, sun-related knowledge and attitudes of Swiss children are scarcely documented. We report the first investigation of the knowledge of the danger of ultraviolet radiation, attitudes towards a suntan and parental influence of schoolchildren in western Switzerland. All fifth, eighth and eleventh graders (average ages of 9, 12 and 15, respectively) in the 18 primary (fifth grade, n=431) and secondary (eighth and eleventh grades, n=837) public schools of La Chaux-de-Fonds were surveyed during regular school classes. The response rate was 91% (1154/1268). Sun-related knowledge was high overall. Eight out of 10 children knew about the risk of skin cancer and recognized the most susceptible phototype. Knowledge increased significantly with age. Girls, older children, fair-skinned participants and those who preferred a tanned skin obtained the highest knowledge score. The main source of information on ultraviolet radiation and sun protection was their parents (76%), followed by the school (11%) and the media (9%). Multivariate logistic regression analyses identified higher sun-related knowledge, lower familial socioprofessional status and skin phototypes III-IV to be associated with a tan-seeking attitude. Parental sensitization (56%) and encouragement (61%) towards sun protection were more common among fair-skinned children and those of higher familial socioprofessional status. The high awareness of the risk of skin cancer among Swiss schoolchildren does not translate into appropriate attitudes. Community-wide intervention programmes involving parents, teachers, peers and primary care clinicians could be considered for Swiss prevention campaigns to improve children's sun behaviour and change their current pro-tan attitude.

  9. KNOWLEDGE AND ATTITUDES RELATED TO HIV/AIDS AMONG MEDICAL AND ALLIED HEALTH SCIENCES STUDENTS

    Directory of Open Access Journals (Sweden)

    Mohammad Akhtar Hussain

    2011-12-01

    Full Text Available Background: India estimates third highest number of HIV infections in the world, with about 2.4 million people currently living with HIV/AIDS. Adequately trained and sensitized healthcare professionals can play a vital role in combating this epidemic. Limited studies have explored knowledge and attitudes of medical students relating to HIV/AIDS, particularly in the eastern part of India. Methods: The present cross sectional study explored knowledge and attitudes of first year MBBS, BDS & BPT students of Kalinga Institute of Medical Sciences (KIMS, Bhubaneswar, Odisha on HIV/AIDS using a self-administered questionnaire. Data thus collected were analyzedand relevant statistics were calculated. Knowledge and attitude scores were determined and analysis of variance (ANOVA test was used to examine the equality between the groups. Results: All students scored low on the overall knowledge scale (<10/15. Specifically, knowledgewas low on modes of transmission and treatment. Attitudinal scores in the areas of precautions and need for training on HIV was low for all the three streams.The willingness to treat HIV/AIDS patient was found to be high amongst study participants. Conclusion: There is a need and scope to provide correct and detailed information on HIV/AIDS for new entrants in medical and allied health sciences to help them acquire adequate knowledge and develop appropriate attitudes towards HIV/AIDS.

  10. ESTIMATION OF THE KNOWLEDGE SPILLOVER EFFECTS BETWEEN FIRMS IN BIO-RELATED INDUSTRIES

    OpenAIRE

    Kim, Hanho; Kim, Jae-Kyung

    2005-01-01

    Knowledge spillover is a kind of externality originating from imperfect appropriation of R&D performances, which implies that the knowledge created by one agent could be transmitted to other related agents by affecting their R&D or other economic performances. For the estimation of knowledge spillover effects based on firm-level patent data between firms in bio-related industries, patents production function, as a proxy of knowledge production function, is formulated and estimated. Knowledge ...

  11. Adequacy of Physicians Knowledge Level of Cardiopulmonary Resuscitation to Current Guidelines

    Directory of Open Access Journals (Sweden)

    Ümmu Kocalar

    2016-01-01

    Full Text Available Aim: The purpose of this study is to test the level of information on CPR and suitability to current application of the phsicians practicing in hospital ANEAH. Material and Method: The form of a test of 20 questions fort his purpose has been prepared in accordance with the 2010 AHA-ERC CPR guidelines. This form distributed to volunteer physicians to fill in. A total of 173 physicians agreed to participate in he study. The results were analyzed statistically and tried to determine the factors affecting the level of information. Results:According to the results of the study physicians gender, age and the total duration of physicians and medical asistance doesn%u2019t affect the level of information. The number of CPR within 1 month positively affect the level of knowledge. The number of theoretical and practical training in medical school, have taken the positive impact the level of knowledge of physicians. The training period after graduation, significantly increased the level of physicians information. The order of these training sessions with the asistant courses, congress, seminars and lessions on the sempozims are effective. Discussion: CPR trainig programs for physicians should be standardized, updated and expanded. Recurent in-service trainig should be provided to increase phsicians knowledge on skills.

  12. Investigation on public knowledge, attitude and practices related to ...

    African Journals Online (AJOL)

    study are to assess the knowledge, attitude and practices towards pet husbandry, ... pet-owning households, with concerted efforts by veterinary, human and public health profes- ... Those benefits include companionship, physical activity, pro-.

  13. Nutrition-related cancer prevention knowledge of undergraduate ...

    African Journals Online (AJOL)

    Oluyemisi Folake Folasire

    A food frequency questionnaire was used to evaluate the dietary pattern. Weight, height, waist and hip ... abdominal obesity while 25.5% had high risk of abdominal obesity. Nutrition ..... significant association between nutrition knowledge on.

  14. HIV/AIDS Related Knowledge and Perceived Risk Associated with ...

    African Journals Online (AJOL)

    Erah

    knowledge base of policy-relevant evidence that would provide new ... coded as 1, and negative attitudes as 0. The questions ..... decision making and vulnerability to STD and HIV/AIDS ... Framing HIV prevention discourse to encompass the ...

  15. Delivering "Just-In-Time" Smoking Cessation Support Via Mobile Phones: Current Knowledge and Future Directions.

    Science.gov (United States)

    Naughton, Felix

    2016-05-28

    Smoking lapses early on during a quit attempt are highly predictive of failing to quit. A large proportion of these lapses are driven by cravings brought about by situational and environmental cues. Use of cognitive-behavioral lapse prevention strategies to combat cue-induced cravings is associated with a reduced risk of lapse, but evidence is lacking in how these strategies can be effectively promoted. Unlike most traditional methods of delivering behavioral support, mobile phones can in principle deliver automated support, including lapse prevention strategy recommendations, Just-In-Time (JIT) for when a smoker is most vulnerable, and prevent early lapse. JIT support can be activated by smokers themselves (user-triggered), by prespecified rules (server-triggered) or through sensors that dynamically monitor a smoker's context and trigger support when a high risk environment is sensed (context-triggered), also known as a Just-In-Time Adaptive Intervention (JITAI). However, research suggests that user-triggered JIT cessation support is seldom used and existing server-triggered JIT support is likely to lack sufficient accuracy to effectively target high-risk situations in real time. Evaluations of mobile phone cessation interventions that include user and/or server-triggered JIT support have yet to adequately assess whether this improves management of high risk situations. While context-triggered systems have the greatest potential to deliver JIT support, there are, as yet, no impact evaluations of such systems. Although it may soon be feasible to learn about and monitor a smoker's context unobtrusively using their smartphone without burdensome data entry, there are several potential advantages to involving the smoker in data collection. This commentary describes the current knowledge on the potential for mobile phones to deliver automated support to help smokers manage or cope with high risk environments or situations for smoking, known as JIT support. The article

  16. The Immunology of Neuromyelitis Optica-Current Knowledge, Clinical Implications, Controversies and Future Perspectives.

    Science.gov (United States)

    Jasiak-Zatonska, Michalina; Kalinowska-Lyszczarz, Alicja; Michalak, Slawomir; Kozubski, Wojciech

    2016-03-02

    Neuromyelitis optica (NMO) is an autoimmune, demyelinating disorder of the central nervous system (CNS) with typical clinical manifestations of optic neuritis and acute transverse myelitis attacks. Previously believed to be a variant of multiple sclerosis (MS), it is now considered an independent disorder which needs to be differentiated from MS. The discovery of autoantibodies against aquaporin-4 (AQP4-IgGs) changed our understanding of NMO immunopathogenesis and revolutionized the diagnostic process. AQP4-IgG is currently regarded as a specific biomarker of NMO and NMO spectrum disorders (NMOsd) and a key factor in its pathogenesis. Nevertheless, AQP4-IgG seronegativity in 10%-25% of NMO patients suggests that there are several other factors involved in NMO immunopathogenesis, i.e., autoantibodies against aquaporin-1 (AQP1-Abs) and antibodies against myelin oligodendrocyte glycoprotein (MOG-IgGs). This manuscript reviews current knowledge about NMO immunopathogenesis, pointing out the controversial issues and showing potential directions for future research. Further efforts should be made to broaden our knowledge of NMO immunology which could have important implications for clinical practice, including the use of potential novel biomarkers to facilitate an early and accurate diagnosis, and modern treatment strategies improving long-term outcome of NMO patients.

  17. The Immunology of Neuromyelitis Optica—Current Knowledge, Clinical Implications, Controversies and Future Perspectives

    Science.gov (United States)

    Jasiak-Zatonska, Michalina; Kalinowska-Lyszczarz, Alicja; Michalak, Slawomir; Kozubski, Wojciech

    2016-01-01

    Neuromyelitis optica (NMO) is an autoimmune, demyelinating disorder of the central nervous system (CNS) with typical clinical manifestations of optic neuritis and acute transverse myelitis attacks. Previously believed to be a variant of multiple sclerosis (MS), it is now considered an independent disorder which needs to be differentiated from MS. The discovery of autoantibodies against aquaporin-4 (AQP4-IgGs) changed our understanding of NMO immunopathogenesis and revolutionized the diagnostic process. AQP4-IgG is currently regarded as a specific biomarker of NMO and NMO spectrum disorders (NMOsd) and a key factor in its pathogenesis. Nevertheless, AQP4-IgG seronegativity in 10%–25% of NMO patients suggests that there are several other factors involved in NMO immunopathogenesis, i.e., autoantibodies against aquaporin-1 (AQP1-Abs) and antibodies against myelin oligodendrocyte glycoprotein (MOG-IgGs). This manuscript reviews current knowledge about NMO immunopathogenesis, pointing out the controversial issues and showing potential directions for future research. Further efforts should be made to broaden our knowledge of NMO immunology which could have important implications for clinical practice, including the use of potential novel biomarkers to facilitate an early and accurate diagnosis, and modern treatment strategies improving long-term outcome of NMO patients. PMID:26950113

  18. Casemix in the Islamic Republic of Iran: current knowledge and attitudes of health care staff.

    Science.gov (United States)

    Ghaffari, S; Doran, C M; Wilson, A

    2008-01-01

    Casemix is a tool that classifies patients according to their clinical similarity and the homogeneity of resources required. A descriptive study was conducted to assess the level of knowledge and attitude toward the casemix-based funding system among staff working in the Iranian Social Security Organization in Tehran. The survey showed that knowledge of casemix and diagnosis-related groups (DRG) was poor among the study group and any attempt to implement the casemix system--which about three-quarters of high-level staff had never heard of--would be likely to fail. This highlights the necessity for creating awareness of the casemix and DRG systems among the hospital staff before any action takes place.

  19. Current-phase relation of a Bose-Einstein condensate flowing through a weak link

    International Nuclear Information System (INIS)

    Piazza, F.; Smerzi, A.; Collins, L. A.

    2010-01-01

    We study the current-phase relation of a Bose-Einstein condensate flowing through a repulsive square barrier by solving analytically the one-dimensional Gross-Pitaevskii equation. The barrier height and width fix the current-phase relation j(δφ), which tends to j∼cos(δφ/2) for weak barriers and to the Josephson sinusoidal relation j∼sin(δφ) for strong barriers. Between these two limits, the current-phase relation depends on the barrier width. In particular, for wide-enough barriers, we observe two families of multivalued current-phase relations. Diagrams belonging to the first family, already known in the literature, can have two different positive values of the current at the same phase difference. The second family, new to our knowledge, can instead allow for three different positive currents still corresponding to the same phase difference. Finally, we show that the multivalued behavior arises from the competition between hydrodynamic and nonlinear-dispersive components of the flow, the latter due to the presence of a soliton inside the barrier region.

  20. Smoking-related knowledge, attitudes, and behaviors among Alaska Native people: a population-based study.

    Science.gov (United States)

    Rohde, Kristen; Boles, Myde; Bushore, Chris J; Pizacani, Barbara A; Maher, Julie E; Peterson, Erin

    2013-01-01

    Several studies have shown that Alaska Native people have higher smoking prevalence than non-Natives. However, no population-based studies have explored whether smoking-related knowledge, attitudes, and behaviors also differ among Alaska Native people and non-Natives. We compared current smoking prevalence and smoking-related knowledge, attitudes, and behavior of Alaska Native adults living in the state of Alaska with non-Natives. We used Alaska Behavioral Risk Factor Surveillance System data for 1996 to 2010 to compare smoking prevalence, consumption, and cessation- and second-hand smoke-related knowledge, attitudes, and behaviors among self-identified Alaska Native people and non-Natives. Current smoking prevalence was 41% (95% CI: 37.9%-44.4%) among Alaska Native people compared with 17.1% (95% CI: 15.9%-18.4%) among non-Natives. Among current every day smokers, Alaska Natives were much more likely to smoke less than 10 cigarettes per day (OR = 5.0, 95% CI: 2.6-9.6) than non-Natives. Compared with non-Native smokers, Alaska Native smokers were as likely to have made a past year quit attempt (OR = 1.4, 95% CI: 0.9-2.1), but the attempt was less likely to be successful (OR = 0.5, 95% CI: 0.2-0.9). Among current smokers, Alaska Natives were more likely to believe second-hand smoke (SHS) was very harmful (OR = 4.5, 95% CI: 2.8-7.2), to believe that smoking should not be allowed in indoor work areas (OR = 1.9, 95% CI: 1.1-3.1) or in restaurants (OR = 4.2, 95% CI: 2.5-6.9), to have a home smoking ban (OR = 2.5, 95% CI: 1.6-3.9), and to have no home exposure to SHS in the past 30 days (OR = 2.3, 95% CI: 1.5-3.6) than non-Natives. Although a disparity in current smoking exists, Alaska Native people have smoking-related knowledge, attitudes, and behaviors that are encouraging for reducing the burden of smoking in this population. Programs should support efforts to promote cessation, prevent relapse, and establish smoke-free environments.

  1. Smoking-related knowledge, attitudes, and behaviours among Alaska Native people: a population-based study

    Directory of Open Access Journals (Sweden)

    Kristen Rohde

    2013-08-01

    Full Text Available Background. Several studies have shown that Alaska Native people have higher smoking prevalence than non-Natives. However, no population-based studies have explored whether smoking-related knowledge, attitudes, and behaviours also differ among Alaska Native people and non-Natives. Objective. We compared current smoking prevalence and smoking-related knowledge, attitudes, and behaviour of Alaska Native adults living in the state of Alaska with non-Natives. Methods. We used Alaska Behavioral Risk Factor Surveillance System data for 1996 to 2010 to compare smoking prevalence, consumption, and cessation- and second-hand smoke-related knowledge, attitudes, and behaviours among self-identified Alaska Native people and non-Natives. Results. Current smoking prevalence was 41% (95% CI: 37.9%–44.4% among Alaska Native people compared with 17.1% (95% CI: 15.9%–18.4% among non-Natives. Among current every day smokers, Alaska Natives were much more likely to smoke less than 10 cigarettes per day (OR=5.0, 95% CI: 2.6–9.6 than non-Natives. Compared with non-Native smokers, Alaska Native smokers were as likely to have made a past year quit attempt (OR=1.4, 95% CI: 0.9–2.1, but the attempt was less likely to be successful (OR=0.5, 95% CI: 0.2–0.9. Among current smokers, Alaska Natives were more likely to believe second-hand smoke (SHS was very harmful (OR=4.5, 95% CI: 2.8–7.2, to believe that smoking should not be allowed in indoor work areas (OR=1.9, 95% CI: 1.1–3.1 or in restaurants (OR=4.2, 95% CI: 2.5–6.9, to have a home smoking ban (OR=2.5, 95% CI: 1.6–3.9, and to have no home exposure to SHS in the past 30 days (OR=2.3, 95% CI: 1.5–3.6 than non-Natives. Conclusion. Although a disparity in current smoking exists, Alaska Native people have smoking-related knowledge, attitudes, and behaviours that are encouraging for reducing the burden of smoking in this population. Programs should support efforts to promote cessation, prevent relapse

  2. Preservice Teachers' Professional Knowledge and Its Relation to Academic Self-Concept

    Science.gov (United States)

    Paulick, Isabell; Großschedl, Jörg; Harms, Ute; Möller, Jens

    2016-01-01

    We investigated the factorial structure of preservice teachers' academic self-concept with regard to three domains of professional knowledge (content knowledge [CK], pedagogical content knowledge [PCK], and pedagogical/psychological knowledge [PPK]). We also analyzed the relation between preservice teachers' academic self-concept and their…

  3. The Baltic policy of Germany and current international relations

    Directory of Open Access Journals (Sweden)

    Salikov Aleksey

    2016-03-01

    Full Text Available This article analyses the Baltic policy of united Germany from the 1990s until today. The authors set out to identify the significance of German-Baltic relations and the role of the Eastern policy in Russian-German relations. The method of dynamic comparison between the political and economic narrative in intergovernmental relations makes it possible to identify distinctive features of Germany’s Baltic policy in the context of current international relations. In particular, it is noted that Germany was most active in the Baltic region in the 1990s, when the country was establishing political, economic, and cultural ties with the new independent states. In the second half of the 1990s, Germany’s foreign policy became less intense. After the accession of Lithuania, Latvia, and Estonia to the EU and NATO in 2004, certain disagreements started to arise between Germany and the Baltics. It explains the lukewarm relations between them. The Ukraine events brought about a change in Germany’s regional policy. Despite Russia remaining one of the key economic and political counteractors, Germany, being a partner of the Baltics in the EU and NATO, cannot adopt a neutral position in the conflict of interests between the Baltics and Russia.

  4. Current safety issues related to research reactor operation

    International Nuclear Information System (INIS)

    Alcala-Ruiz, F.

    2000-01-01

    The Agency has included activities on research reactor safety in its Programme and Budget (P and B) since its inception in 1957. Since then, these activities have traditionally been oriented to fulfil the Agency's functions and obligations. At the end of the decade of the eighties, the Agency's Research Reactor Safety Programme (RRSP) consisted of a limited number of tasks related to the preparation of safety related publications and the conduct of safety missions to research reactor facilities. It was at the beginning of the nineties when the RRSP was upgraded and expanded as a subprogramme of the Agency's P and B. This subprogramme continued including activities related to the above subjects and started addressing an increasing number of issues related to the current situation of research reactors (in operation and shut down) around the world such as reactor ageing, modifications and decommissioning. The present paper discusses some of the above issues as recognised by various external review or advisory groups (e.g., Peer Review Groups under the Agency's Performance Programme Appraisal System (PPAS) or the standing International Nuclear Safety Advisory Group (INSAG)) and the impact of their recommendations on the preparation and implementation of the part of the Agency's P and B relating to the above subject. (author)

  5. Relating Knowledge about Reading to Teaching Practice: An Exploratory Validity Study of a Teacher Knowledge Assessment

    Science.gov (United States)

    Phelps, Geoffrey; Johnson, David; Carlisle, Joanne

    2009-01-01

    The research reported in this paper is focused directly on assessing the validity of the "Teaching Knowledge about Reading and Reading Practices" (TKRRP) assessment. Following the recommendations of the Standards for Educational and Psychological Testing (APA/AERA, 1999), the authors see validation as a process of constructing an…

  6. Knowledge and practices related to sexually transmitted infections ...

    African Journals Online (AJOL)

    Background: Sexually transmitted infections (STIs) still stand as one of the commonest health problems affecting women of reproductive age. The knowledge and .... With the help of local leaders, one of 4 in- terview teams approached ... Ethical clearance to conduct the study was sought from the Makerere University School ...

  7. Oral health related knowledge and behaviour among nursing ...

    African Journals Online (AJOL)

    Aim: To investigate oral health knowledge and behaviour amongst nursing students in a Nigerian tertiary hospital. Materials and methods: The study was conducted at University of Nigeria Teaching Hospital on respondents aged 17 to 40 years, using self administered structured questionnaire. Result: From oral health ...

  8. KNK-II knowledge preservation and related activities in Germany

    International Nuclear Information System (INIS)

    Knebel, J.; Wehmann, U.; Stanculescu, A.

    2004-01-01

    Many of the scenarios describing possible energy futures, e.g., the World Energy Council and the Intergovernmental Panel on Climate Change (IPCC), foresee a role for nuclear power in meeting a growing world energy demand through 2050. While some scenarios explore the impact of a nuclear phase out, others envision a major growth in nuclear technology's share of the world energy mix. Given the forecasted growth in world population and in economic development, the environmental advantages of nuclear power, and concerns over climate change and the growth of greenhouse gas emissions, it is not unreasonable to expect an increased interest in nuclear power in the coming decades. Loss of nuclear knowledge is a serious concern, in particular with regard to areas where, for various reasons, nuclear technology development and innovation has been slowed down. Knowledge can be preserved by archival techniques and by passing it on to new generations. In the case of the Federal Republic of Germany, in spite of the lack of funding and political support, both avenues are followed. Data retrieval and preservation by archiving activities for the German experimental fast reactor KNK-II were undertaken within the framework of IAEA's initiative on Fast Reactor Knowledge Preservation. The paper will shortly introduce the IAEA initiative (scope, objectives, status, and outlook). The general approach to nuclear knowledge preservation in Germany will be presented, and the concrete archiving activities undertaken for KNK-II will be summarized. (author)

  9. Knowledge, attitudes and practices relating to malaria in a semi ...

    African Journals Online (AJOL)

    sectional study in a semi-urban setting. Two hundred and fifty ... Most (27.06%) of those who had the correct knowledge of malarial resistance were in the age group 31-35 bracket compared with other age groups (P>0.05). There was no difference in ...

  10. What's Past is Prologue: Relations Between Early Mathematics Knowledge and High School Achievement.

    Science.gov (United States)

    Watts, Tyler W; Duncan, Greg J; Siegler, Robert S; Davis-Kean, Pamela E

    2014-10-01

    Although previous research has established the association between early-grade mathematics knowledge and later mathematics achievement, few studies have measured mathematical skills prior to school entry, nor have they investigated the predictive power of early gains in mathematics ability. The current paper relates mathematical skills measured at 54 months to adolescent mathematics achievement using multi-site longitudinal data. We find that preschool mathematics ability predicts mathematics achievement through age 15, even after accounting for early reading, cognitive skills, and family and child characteristics. Moreover, we find that growth in mathematical ability between age 54 months and first grade is an even stronger predictor of adolescent mathematics achievement. These results demonstrate the importance of pre-kindergarten mathematics knowledge and early math learning for later achievement.

  11. What’s Past is Prologue: Relations Between Early Mathematics Knowledge and High School Achievement

    Science.gov (United States)

    Watts, Tyler W.; Duncan, Greg J.; Siegler, Robert S.; Davis-Kean, Pamela E.

    2015-01-01

    Although previous research has established the association between early-grade mathematics knowledge and later mathematics achievement, few studies have measured mathematical skills prior to school entry, nor have they investigated the predictive power of early gains in mathematics ability. The current paper relates mathematical skills measured at 54 months to adolescent mathematics achievement using multi-site longitudinal data. We find that preschool mathematics ability predicts mathematics achievement through age 15, even after accounting for early reading, cognitive skills, and family and child characteristics. Moreover, we find that growth in mathematical ability between age 54 months and first grade is an even stronger predictor of adolescent mathematics achievement. These results demonstrate the importance of pre-kindergarten mathematics knowledge and early math learning for later achievement. PMID:26806961

  12. Assessing exposure and health consequences of chemicals in drinking water: current state of knowledge and research needs.

    Science.gov (United States)

    Villanueva, Cristina M; Kogevinas, Manolis; Cordier, Sylvaine; Templeton, Michael R; Vermeulen, Roel; Nuckols, John R; Nieuwenhuijsen, Mark J; Levallois, Patrick

    2014-03-01

    Safe drinking water is essential for well-being. Although microbiological contamination remains the largest cause of water-related morbidity and mortality globally, chemicals in water supplies may also cause disease, and evidence of the human health consequences is limited or lacking for many of them. We aimed to summarize the state of knowledge, identify gaps in understanding, and provide recommendations for epidemiological research relating to chemicals occurring in drinking water. Assessing exposure and the health consequences of chemicals in drinking water is challenging. Exposures are typically at low concentrations, measurements in water are frequently insufficient, chemicals are present in mixtures, exposure periods are usually long, multiple exposure routes may be involved, and valid biomarkers reflecting the relevant exposure period are scarce. In addition, the magnitude of the relative risks tends to be small. Research should include well-designed epidemiological studies covering regions with contrasting contaminant levels and sufficient sample size; comprehensive evaluation of contaminant occurrence in combination with bioassays integrating the effect of complex mixtures; sufficient numbers of measurements in water to evaluate geographical and temporal variability; detailed information on personal habits resulting in exposure (e.g., ingestion, showering, swimming, diet); collection of biological samples to measure relevant biomarkers; and advanced statistical models to estimate exposure and relative risks, considering methods to address measurement error. Last, the incorporation of molecular markers of early biological effects and genetic susceptibility is essential to understand the mechanisms of action. There is a particular knowledge gap and need to evaluate human exposure and the risks of a wide range of emerging contaminants. Villanueva CM, Kogevinas M, Cordier S, Templeton MR, Vermeulen R, Nuckols JR, Nieuwenhuijsen MJ, Levallois P. 2014. Assessing

  13. Knowledge in Action: Fitness Lesson Segments That Teach Health-Related Fitness in Elementary Physical Education

    Science.gov (United States)

    Hodges, Michael G.; Kulinna, Pamela Hodges; van der Mars, Hans; Lee, Chong

    2016-01-01

    The purpose of this study was to determine students' health-related fitness knowledge (HRFK) and physical activity levels after the implementation of a series of fitness lessons segments called Knowledge in Action (KIA). KIA aims to teach health-related fitness knowledge (HRFK) during short episodes of the physical education lesson. Teacher…

  14. [Specific inhibitors of cyclooxygenase-2 (COX-2): current knowledge and perspectives].

    Science.gov (United States)

    Rioda, W T; Nervetti, A

    2001-01-01

    The Authors summarize the current knowledge on a new class of nonsteroidal anti-inflammatory drugs (NSAIDs), the coxib (celecoxib and rofecoxib), in the treatment of rheumatic diseases. Celecoxib and rofecoxib are selective cyclooxygenase-2 (COX-2) inhibitors which possess the same anti-inflammatory and analgesic activities, but a better gastric tolerability compared to the non-selective COX-1 and COX-2 inhibitors. The Authors also report other possible therapeutic effects of these NSADIs as evidenced by the more recent data of the literature. Celecoxib seems to reduce the incidence of new polyps in patients with familial adenomatous polyposis. It has been suggested the use of celecoxib as a protective drug against the development of colorectal cancer. Other (neoplastic) or pre-neoplastic conditions, such as bladder dysplasia, Barret esophagus, attinic keratosis and Alzheimer's disease seem to have benefit from this class of drugs.

  15. The priming of storage glucan synthesis from bacteria to plants: current knowledge and new developments.

    Science.gov (United States)

    D'Hulst, Christophe; Mérida, Angel

    2010-10-01

    Starch is the main polymer in which carbon and energy are stored in land plants, algae and some cyanobacteria. It plays a crucial role in the physiology of these organisms and also represents an important polymer for humans, in terms of both diet and nonfood industry uses. Recent efforts have elucidated most of the steps involved in the synthesis of starch. However, the process that initiates the synthesis of the starch granule remains unclear. Here, we outline the similarities between the synthesis of starch and the synthesis of glycogen, the other widespread and abundant glucose-based polymer in living cells. We place special emphasis on the mechanisms of initiation of the glycogen granule and current knowledge concerning the initiation of the starch granule. We also discuss recent discoveries regarding the function of starch synthases in the priming of the starch granule and possible interactions with other elements of the starch synthesis machinery.

  16. Current State of Knowledge About Cancer in Lesbians, Gay, Bisexual, and Transgender (LGBT) People.

    Science.gov (United States)

    Margolies, Liz; Brown, Carlton G

    2018-02-01

    To review the current state of knowledge about cancer in lesbians, gay, bisexual, and transgender (LGBT) people by focusing on four major issues across the cancer continuum including: 1) lack of data collection on sexual orientation and gender identity; 2) need for a culturally competent workforce; 3) the need for a culturally competent health care system; and 4) creating LGBT tailored patient/client information and education. Published literature. Oncology nurses and health care providers can work to improve the care of LGBT patients with cancer by following suggestions in this article. Oncology nurses and other health care providers have many distinct occasions to improve overall cancer care for LGBT patients. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. A critical review of the current knowledge regarding the biological impact of nanocellulose.

    Science.gov (United States)

    Endes, C; Camarero-Espinosa, S; Mueller, S; Foster, E J; Petri-Fink, A; Rothen-Rutishauser, B; Weder, C; Clift, M J D

    2016-12-01

    Several forms of nanocellulose, notably cellulose nanocrystals and nanofibrillated cellulose, exhibit attractive property matrices and are potentially useful for a large number of industrial applications. These include the paper and cardboard industry, use as reinforcing filler in polymer composites, basis for low-density foams, additive in adhesives and paints, as well as a wide variety of food, hygiene, cosmetic, and medical products. Although the commercial exploitation of nanocellulose has already commenced, little is known as to the potential biological impact of nanocellulose, particularly in its raw form. This review provides a comprehensive and critical review of the current state of knowledge of nanocellulose in this format. Overall, the data seems to suggest that when investigated under realistic doses and exposure scenarios, nanocellulose has a limited associated toxic potential, albeit certain forms of nanocellulose can be associated with more hazardous biological behavior due to their specific physical characteristics.

  18. Pangolins (Manis crassicaudata in Sri Lanka: A Review of Current Knowledge, Threats and Research Priorities

    Directory of Open Access Journals (Sweden)

    P.K.P. Perera

    2017-07-01

    Full Text Available The Indian Pangolin (Manis crassicaudata is arguably the least studied species of all Asiatic pangolin species and, is the solitary pangolin species recorded in Sri Lanka. Growing concerns over their population decline due to poaching and trading has triggered a move to uplift Indian Pangolin to Appendix I of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES. However, lack of reliable scientific information on the behavior, ecology and threats for the survival of Indian Pangolin remains a major limitation in conservation of the species. This narrative review discusses the current knowledge on Indian Pangolin with special reference to Sri Lanka, and identifies key research priorities for better conservation planning of the species.

  19. Current Knowledge and Practice of Pediatric Providers in Umbilical Cord Blood Banking.

    Science.gov (United States)

    Armstrong, Amy E; Fonstad, Rachel; Spellman, Stephen; Tullius, Zoe; Chaudhury, Sonali

    2018-02-01

    More than 35 000 umbilical cord blood (UCB) transplants have been performed worldwide, prompting the development of private and public banks to collect and store UCB cells. We hypothesized that pediatricians, who are uniquely poised to discuss UCB banking (UCBB) during prenatal or sibling visits, rarely do so. Through distribution of a 26-question electronic survey to general and subspecialty pediatric providers, we assessed baseline knowledge and conversations about UCBB. A total of 473 providers completed the survey; only 22% of physicians ever discussed UCBB with expectant parents. The majority responded that autologous UCB transplants were indicated in malignant (73%) and nonmalignant (61%) conditions; however, these are rare indications. Providers practicing >10 years were more likely to address UCBB ( P ≤ .001), whereas younger and female general pediatric providers were significantly less likely ( P < .001). Overall, pediatric providers rarely speak to families about UCBB, and we believe that they can be better informed to its current clinical utility.

  20. Chemical and molecular factors in irritable bowel syndrome: current knowledge, challenges, and unanswered questions.

    Science.gov (United States)

    Camilleri, Michael; Oduyebo, Ibironke; Halawi, Houssam

    2016-11-01

    Several chemical and molecular factors in the intestine are reported to be altered and to have a potentially significant role in irritable bowel syndrome (IBS), particularly in IBS with diarrhea. These include bile acids; short-chain fatty acids; mucosal barrier proteins; mast cell products such as histamine, proteases, and tryptase; enteroendocrine cell products; and mucosal mRNAs, proteins, and microRNAs. This article reviews the current knowledge and unanswered questions in the pathobiology of the chemical and molecular factors in IBS. Evidence continues to point to significant roles in pathogenesis of these chemical and molecular mechanisms, which may therefore constitute potential targets for future research and therapy. However, it is still necessary to address the interaction between these factors in the gut and to appraise how they may influence hypervigilance in the central nervous system in patients with IBS. Copyright © 2016 the American Physiological Society.

  1. The Role of Soil Microorganisms in Plant Mineral Nutrition—Current Knowledge and Future Directions

    Science.gov (United States)

    Jacoby, Richard; Peukert, Manuela; Succurro, Antonella; Koprivova, Anna; Kopriva, Stanislav

    2017-01-01

    In their natural environment, plants are part of a rich ecosystem including numerous and diverse microorganisms in the soil. It has been long recognized that some of these microbes, such as mycorrhizal fungi or nitrogen fixing symbiotic bacteria, play important roles in plant performance by improving mineral nutrition. However, the full range of microbes associated with plants and their potential to replace synthetic agricultural inputs has only recently started to be uncovered. In the last few years, a great progress has been made in the knowledge on composition of rhizospheric microbiomes and their dynamics. There is clear evidence that plants shape microbiome structures, most probably by root exudates, and also that bacteria have developed various adaptations to thrive in the rhizospheric niche. The mechanisms of these interactions and the processes driving the alterations in microbiomes are, however, largely unknown. In this review, we focus on the interaction of plants and root associated bacteria enhancing plant mineral nutrition, summarizing the current knowledge in several research fields that can converge to improve our understanding of the molecular mechanisms underpinning this phenomenon. PMID:28974956

  2. Current Research on Containment Technologies for Verification Activities: Advanced Tools for Maintaining Continuity of Knowledge

    International Nuclear Information System (INIS)

    Smartt, H.; Kuhn, M.; Krementz, D.

    2015-01-01

    The U.S. National Nuclear Security Administration (NNSA) Office of Non-proliferation and Verification Research and Development currently funds research on advanced containment technologies to support Continuity of Knowledge (CoK) objectives for verification regimes. One effort in this area is the Advanced Tools for Maintaining Continuity of Knowledge (ATCK) project. Recognizing that CoK assurances must withstand potential threats from sophisticated adversaries, and that containment options must therefore keep pace with technology advances, the NNSA research and development on advanced containment tools is an important investment. The two ATCK efforts underway at present address the technical containment requirements for securing access points (loop seals) and protecting defined volumes. Multiple U.S. national laboratories are supporting this project: Sandia National Laboratories (SNL), Savannah River National Laboratory (SRNL), and Oak Ridge National Laboratory (ORNL). SNL and SRNL are developing the ''Ceramic Seal,'' an active loop seal that integrates multiple advanced security capabilities and improved efficiency housed within a small-volume ceramic body. The development includes an associated handheld reader and interface software. Currently at the prototype stage, the Ceramic Seal will undergo a series of tests to determine operational readiness. It will be field tested in a representative verification trial in 2016. ORNL is developing the Whole Volume Containment Seal (WCS), a flexible conductive fabric capable of enclosing various sizes and shapes of monitored items. The WCS includes a distributed impedance measurement system for imaging the fabric surface area and passive tamper-indicating features such as permanent-staining conductive ink. With the expected technology advances from the Ceramic Seal and WCS, the ATCK project takes significant steps in advancing containment technologies to help maintain CoK for various verification

  3. Current knowledge of scoliosis in physiotherapy students trained in the United Kingdom.

    Science.gov (United States)

    Black, D A Jason; Pilcher, Christine; Drake, Shawn; Maude, Erika; Glynn, David

    2017-01-01

    the UK performed worse in relation to all questions except treatment (7% answered correctly vs 3% in the American study). With only 7% of students able to answer > 50% of the survey questions correctly, there is a clear lack of knowledge of appropriate IS diagnosis and care which could directly impact the information these patients are given within the first contact primary care in the UK.

  4. Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health.

    Science.gov (United States)

    Stephen, Alison M; Champ, Martine M-J; Cloran, Susan J; Fleith, Mathilde; van Lieshout, Lilou; Mejborn, Heddie; Burley, Victoria J

    2017-12-01

    Research into the analysis, physical properties and health effects of dietary fibre has continued steadily over the last 40-50 years. From the knowledge gained, countries have developed guidelines for their populations on the optimal amount of fibre to be consumed each day. Food composition tables from many countries now contain values for the dietary fibre content of foods, and, from these, combined with dietary surveys, population intakes have been determined. The present review assessed the uniformity of the analytical methods used, health claims permitted, recommendations and intakes, particularly from national surveys across Europe and around the world. It also assessed current knowledge on health effects of dietary fibre and related the impact of different fibre types on health. The overall intent was to be able to provide more detailed guidance on the types of fibre which should be consumed for good health, rather than simply a total intake figure, the current situation. Analysis of data indicated a fair degree of uniformity in the definition of dietary fibre, the method used for analysis, the recommended amount to be consumed and a growing literature on effects on digestive health and disease risk. However, national dietary survey data showed that intakes do not reach recommendations and very few countries provide guidance on the types of fibre that are preferable to achieve recommended intakes. Research gaps were identified and ideas suggested to provide information for more detailed advice to the public about specific food sources that should be consumed to achieve health benefits.

  5. Current state about the cuaternary knowledge of Uruguay; Estado actual sobre los conocimientos del cuaternario en Uruguay

    Energy Technology Data Exchange (ETDEWEB)

    Anton, D; Goso, H

    1974-07-01

    This work is about current state of cuaternary knowledge Uruguayan. It is considered that the cuaternary presented a change from the hot and dry weather of the Pliocene to more humid and colder weather in Uruguay.

  6. Beer Polyphenols and Menopause: Effects and Mechanisms—A Review of Current Knowledge

    Science.gov (United States)

    Sandoval-Ramírez, Berner Andrée; M. Lamuela-Raventós, Rosa; Estruch, Ramon; Sasot, Gemma; Doménech, Monica

    2017-01-01

    Beer is one of the most frequently consumed fermented beverages in the world, and it has been part of the human diet for thousands of years. Scientific evidence obtained from the development of new techniques of food analysis over the last two decades suggests that polyphenol intake derived from moderate beer consumption may play a positive role in different health outcomes including osteoporosis and cardiovascular risk and the relief of vasomotor symptoms, which are commonly experienced during menopause and are an important reason why women seek medical care during this period; here, we review the current knowledge regarding moderate beer consumption and its possible effects on menopausal symptoms. The effect of polyphenol intake on vasomotor symptoms in menopause may be driven by the direct interaction of the phenolic compounds present in beer, such as 8-prenylnaringenin, 6-prenylnaringenin, and isoxanthohumol, with intracellular estrogen receptors that leads to the modulation of gene expression, increase in sex hormone plasma concentrations, and thus modulation of physiological hormone imbalance in menopausal women. Since traditional hormone replacement therapies increase health risks, alternative, safer treatment options are needed to alleviate menopausal symptoms in women. The present work aims to review the current data on this subject. PMID:28904736

  7. Organizational options for preventing work-related stress in knowledge work

    DEFF Research Database (Denmark)

    Ipsen, Christine; Jensen, Per Langaa

    2012-01-01

    Recent studies point to work-related stress as an increasing problem for knowledge workers. However, the working life in knowledge-intensive companies is often described as good and stimulating. The aim of this study is to explore the organizational options for preventing work-related problems...... in knowledge work. This calls for a study of the characteristics of knowledge work, stress management interventions and an in-depth analysis of the organizational factors causing frustrations and work-related problems in relation to knowledge work. In a qualitative study, 27 respondents were interviewed....... They represented different stakeholders in five Danish knowledge-intensive companies, which comprised two consultancies and three engineering consulting companies. The study shows that knowledge work comprises a paradox, since the same work-related or organizational issues could be experienced as both...

  8. Women with epilepsy in childbearing age: Pregnancy-related knowledge, information sources, and antiepileptic drugs.

    Science.gov (United States)

    Friedrich, Latica; Sruk, Ana; Bielen, Ivan

    2018-03-01

    Pregnancy-related issues in epilepsy (PRIE) are essential for management of epilepsy in women. We conducted a study among women with epilepsy (WWE) aged 15-45years about their knowledge, sources, and needs for information regarding PRIE, which included their current antiepileptic drugs (AEDs) usage. Women with epilepsy, visitors of Croatian Association for Epilepsy webpage, were offered an online questionnaire, and 200 responses were analyzed. The mean number of correct answers about PRIE was 3.5 out of 5. Main predictors of knowledge on PRIE were a prior consultation with a neurologist and higher usage of books/brochures. A prior neurologist consultation on PRIE was stated by 45% of subjects. As the preferred future mode of being informed on PRIE, majority of women (61%) chooses their neurologist, 22% written materials distributed by a neurologist, and only 13% Internet. Levetiracetam was the most commonly used AED (34.5%). Valproate was used by 26%, and of those 59% stated no previous consultation on PRIE with their neurologist. In summary, we believe our study shows that knowledge of PRIE among WWE in their childbearing age is unsatisfactory, as are the neurologist consultation rates about PRIE. Our results demonstrate that, despite modern technologies, educational activities should be based on neurologist consultations and providing the patients with appropriate written materials. This is especially true for the relatively large proportion of women still taking valproate. Copyright © 2018 Elsevier Inc. All rights reserved.

  9. Physician Knowledge and Attitudes About Hepatitis A and Current Practices Regarding Hepatitis A Vaccination Delivery.

    Science.gov (United States)

    Nelson, Noele P; Allison, Mandy A; Lindley, Megan C; Brtnikova, Michaela; Crane, Lori A; Beaty, Brenda L; Hurley, Laura P; Kempe, Allison

    2017-07-01

    To assess physicians': 1) knowledge and attitudes about hepatitis A disease and hepatitis A (HepA) vaccine, 2) child care and school HepA vaccine mandates, 3) practices related to HepA vaccine delivery, 4) factors associated with strongly recommending HepA vaccine to all 1- to 2-year-olds, and 5) feasibility of implementing HepA catch-up vaccination at health maintenance visits. A national survey was conducted among representative networks of pediatricians and family medicine physicians (FMs) from March to June, 2014 via e-mail or mail on the basis of provider preference. Response rates were 81% (356 of 440) among pediatricians and 75% (348 of 464) among FMs. Less than 50% correctly identified that hepatitis A virus (HAV) infection is usually asymptomatic in young children and that morbidity from HAV disease increases with age. Ninety-two percent of pediatricians and 59% of FMs strongly recommend HepA vaccine for all 1- to 2-year-olds. In addition to practice specialty, belief that HepA vaccine is required for kindergarten enrollment was the most robust predictor of strong physician recommendation. Gaps in knowledge regarding HAV infection and hepatitis A recommendations and lack of a strong recommendation for routine HepA vaccination of young children among FMs likely contribute to suboptimal coverage. Closing knowledge gaps and addressing barriers that prevent all physicians from strongly recommending HepA vaccine to 1- to 2-year-olds could help increase HepA vaccine coverage and ultimately improve population protection against HAV infection. Published by Elsevier Inc.

  10. Relation between magnetic fields and electric currents in plasmas

    Directory of Open Access Journals (Sweden)

    V. M. Vasyliunas

    2005-10-01

    Full Text Available Maxwell's equations allow the magnetic field B to be calculated if the electric current density J is assumed to be completely known as a function of space and time. The charged particles that constitute the current, however, are subject to Newton's laws as well, and J can be changed by forces acting on charged particles. Particularly in plasmas, where the concentration of charged particles is high, the effect of the electromagnetic field calculated from a given J on J itself cannot be ignored. Whereas in ordinary laboratory physics one is accustomed to take J as primary and B as derived from J, it is often asserted that in plasmas B should be viewed as primary and J as derived from B simply as (c/4π∇×B. Here I investigate the relation between ∇×B and J in the same terms and by the same method as previously applied to the MHD relation between the electric field and the plasma bulk flow vmv2001: assume that one but not the other is present initially, and calculate what happens. The result is that, for configurations with spatial scales much larger than the electron inertial length λe, a given ∇×B produces the corresponding J, while a given J does not produce any ∇×B but disappears instead. The reason for this can be understood by noting that ∇×B≠4π/cJ implies a time-varying electric field (displacement current which acts to change both terms (in order to bring them toward equality; the changes in the two terms, however, proceed on different time scales, light travel time for B and electron plasma period for J, and clearly the term changing much more slowly is the one that survives. (By definition, the two time scales are equal at λe. On larger scales, the evolution of B (and hence also of ∇×B is governed by

  11. Effects of biodiversity on ecosystem functioning: a consensus of current knowledge

    Science.gov (United States)

    Hooper, D.U.; Chapin, F. S.; Ewel, J.J.; Hector, A.; Inchausti, P.; Lavorel, S.; Lawton, J.H.; Lodge, D.M.; Loreau, M.; Naeem, S.; Schmid, B.; SetSlS, H.; Symstad, A.J.; Vandermeer, J.; Wardle, D.A.

    2005-01-01

    Humans are altering the composition of biological communities through a variety of activities that increase rates of species invasions and species extinctions, at all scales, from local to global. These changes in components of the Earth's biodiversity cause concern for ethical and aesthetic reasons, but they also have a strong potential to alter ecosystem properties and the goods and services they provide to humanity. Ecological experiments, observations, and theoretical developments show that ecosystem properties depend greatly on biodiversity in terms of the functional characteristics of organisms present in the ecosystem and the distribution and abundance of those organisms over space and time. Species effects act in concert with the effects of climate, resource availability, and disturbance regimes in influencing ecosystem properties. Human activities can modify all of the above factors; here we focus on modification of these biotic controls.The scientific community has come to a broad consensus on many aspects of the relationship between biodiversity and ecosystem functioning, including many points relevant to management of ecosystems. Further progress will require integration of knowledge about biotic and abiotic controls on ecosystem properties, how ecological communities are structured, and the forces driving species extinctions and invasions. To strengthen links to policy and management, we also need to integrate our ecological knowledge with understanding of the social and economic constraints of potential management practices. Understanding this complexity, while taking strong steps to minimize current losses of species, is necessary for responsible management of Earth's ecosystems and the diverse biota they contain.Based on our review of the scientific literature, we are certain of the following conclusions:1) Species' functional characteristics strongly influence ecosystem properties. Functional characteristics operate in a variety of contexts

  12. Sexual and reproductive health status and related knowledge among female migrant workers in Guangzhou, China: a cross-sectional survey

    NARCIS (Netherlands)

    Lu, C.; Xu, L.; Wu, J.; Wang, Z.; Decat, P.; Zhang, W.-H.; Cheng, Y.; Moyer, E.; Wu, S.; Minkauskiene, M.; van Braeckel, D.; Temmerman, M.

    2012-01-01

    The objective of this study was to investigate the current sexual and reproductive health (SRH) status including SRH-related knowledge and associated factors, self-reported symptoms of reproductive tract infection (RTI), medical assistance seeking behavior, sexual experience and contraceptive use,

  13. Knowledge, Beliefs and Behaviours Related to STD Risk, Prevention, and Screening among a Sample of African American Men and Women

    Science.gov (United States)

    Uhrig, Jennifer D.; Friedman, Allison; Poehlman, Jon; Scales, Monica; Forsythe, Ann

    2014-01-01

    Objective: Current data on sexually transmitted disease (STD) among African Americans show significant racial/ethnic disparities. The purpose of this study was to explore knowledge, attitudes, beliefs, and behaviours related to STD risk, prevention, and testing among African American adults to help inform the development of a health communication…

  14. Knowledge and attitudes of physicians relating to reporting of ...

    African Journals Online (AJOL)

    appraise the current documentation of ADR in Sokoto, to analyze the extent to which ... on each of the Inman's attitude measured except that more experienced physicians ..... be consistent with known non-assertiveness of ... less assertive behaviors in clinical scenarios. ... given by patients on ADRs, information processing.

  15. Investigation on public knowledge, attitude and practices related to ...

    African Journals Online (AJOL)

    meat to their dogs and 79.3% of the owners obtained the meat from local unlicensed markets. The majority of the respondents (87%) in the current study believed the risk of acquiring zoonotic diseases from dogs. However, most of them (95.4%) knew only rabies and only 4.6% of them knew parasitic diseases in addition to ...

  16. Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Perspective on Current Evidence and Clinical Knowledge

    Directory of Open Access Journals (Sweden)

    Ali Habib

    2012-01-01

    Full Text Available This paper reviews the current published data regarding open transforaminal lumbar interbody fusion (TLIF in relation to minimally invasive transforaminal lumbar interbody fusion (MI-TLIF. Introduction. MI-TLIF, a modern method for lumbar interbody arthrodesis, has allowed for a minimally invasive method to treat degenerative spinal pathologies. Currently, there is limited literature that compares TLIF directly to MI-TLIF. Thus, we seek to discuss the current literature on these techniques. Methods. Using a PubMed search, we reviewed recent publications of open and MI-TLIF, dating from 2002 to 2012. We discussed these studies and their findings in this paper, focusing on patient-reported outcomes as well as complications. Results. Data found in 14 articles of the literature was analyzed. Using these reports, we found mean follow-up was 20 months. The mean patient study size was 52. Seven of the articles directly compared outcomes of open TLIF with MI-TLIF, such as mean duration of surgery, length of post-operative stay, blood loss, and complications. Conclusion. Although high-class data comparing these two techniques is lacking, the current evidence supports MI-TLIF with outcomes comparable to that of the traditional, open technique. Further prospective, randomized studies will help to further our understanding of this minimally invasive technique.

  17. Text Processing of Domain-Related Information for Individuals with High and Low Domain Knowledge.

    Science.gov (United States)

    Spilich, George J.; And Others

    1979-01-01

    The way in which previously acquired knowledge affects the processing on new domain-related information was investigated. Text processing was studied in two groups differing in knowledge of the domain of baseball. A knowledge structure for the domain was constructed, and text propositions were classified. (SW)

  18. Student Teachers' Knowledge about Children with ADHD and Depression and Its Relations to Emotions

    Science.gov (United States)

    Kikas, Eve; Timoštšuk, Inge

    2016-01-01

    Student teachers' knowledge about children with attention deficit hyperactivity disorder (ADHD) and depression and its relations to reporting experiencing emotions during teaching practice were studied. The participants were 186 teacher education students in Estonia. Student teachers' general knowledge and confidence in knowledge varied a lot.…

  19. Relation Analysis of Knowledge Management, Research, and Innovation in University Research Groups

    Directory of Open Access Journals (Sweden)

    Heyder Paez-Logreira

    2016-12-01

    Full Text Available Knowledge is a competitive advantage for companies. Knowledge Management helps to keep this competitiveness. Universities face with challenges in research, innovation and international competitiveness. The purpose of this paper includes studying Knowledge Management Models, and Innovation Models apply to Research Groups of Universities, through an analysis of relation in inter-organizational level. Some researchers and leaders of research groups participated in a survey about knowledge management and innovation. Here we show the relationship between knowledge management, innovation and research, including processes and operations performed by universities around these. We organize the results in three dimensions: Knowledge Management perception, the relationship between Knowledge Management and Innovation, and Strategic Knowledge organization. Too, we identify a generality of good practices, challenges, and limitations on Research Groups for Knowledge Management.

  20. A review on current knowledge and future prospects of organohalogen contaminants (OHCs) in Asian birds.

    Science.gov (United States)

    Abbasi, Naeem Akhtar; Malik, Riffat Naseem; Frantz, Adrien; Jaspers, Veerle Leontina Bernard

    2016-01-15

    The release of harmful chemicals in the Asian environment has recently increased dramatically due to rising industrial and agricultural activities. About 60% of the global human population is currently living on the Asian continent and may thus be exposed to a large range of different chemicals. Different classes of organohalogen chemicals have indeed been reported in various environmental compartments from Asia including humans and wildlife, but this issue has received less attention in birds. In this article, we reviewed the available literature on levels of legacy persistent organic pollutants (POPs) and various flame retardants (FRs) in Asian avifauna to analyze the existing pool of knowledge as well as to identify the gaps that should be addressed in future research. Furthermore, we discussed the variation in levels of organohalogens based on differences in regions, trophic level, dietary sources and migratory behaviors of species including distribution patterns in different tissues of birds. Although the mass of published literature is very low and even absent in many important regions of Asia, we deduced from the reported studies that levels of almost all classes of organohalogens (OHCs) including FRs were highest in East Asian countries such as Japan, China and South Korea, except for HCHs that were found at maximum levels in birds of South India. Concentrations (ng/g LW) of different OHCs in Asian birds ranged between birds, vicinity to sources and trans-boundary movement of pollutants were identified as key exposure routes and subsequent OHCs contamination in Asian birds. There is extreme scarcity of literature on organohalogen contamination in birds from Northern, South-eastern and west Asian countries where an industrial boom has been witnessed in the past few decades. Current scenarios suggest that levels of OHCs, particularly the FRs, are rising in birds of Asia and it would be wise to develop baseline information and to regulate the OHCs emission

  1. Exploring the function and effectiveness of knowledge brokers as facilitators of knowledge translation in health-related settings: a systematic review and thematic analysis.

    Science.gov (United States)

    Bornbaum, Catherine C; Kornas, Kathy; Peirson, Leslea; Rosella, Laura C

    2015-11-20

    Knowledge brokers (KBs) work collaboratively with key stakeholders to facilitate the transfer and exchange of information in a given context. Currently, there is a perceived lack of evidence about the effectiveness of knowledge brokering and the factors that influence its success as a knowledge translation (KT) mechanism. Thus, the goal of this review was to systematically gather evidence regarding the nature of knowledge brokering in health-related settings and determine if KBs effectively contributed to KT in these settings. A systematic review was conducted using a search strategy designed by a health research librarian. Eight electronic databases (MEDLINE, Embase, PsycINFO, CINAHL, ERIC, Scopus, SocINDEX, and Health Business Elite) and relevant grey literature sources were searched using English language restrictions. Two reviewers independently screened the abstracts, reviewed full-text articles, extracted data, and performed quality assessments. Analysis included a confirmatory thematic approach. To be included, studies must have occurred in a health-related setting, reported on an actual application of knowledge brokering, and be available in English. In total, 7935 records were located. Following removal of duplicates, 6936 abstracts were screened and 240 full-text articles were reviewed. Ultimately, 29 articles, representing 22 unique studies, were included in the thematic analysis. Qualitative (n = 18), quantitative (n = 1), and mixed methods (n = 6) designs were represented in addition to grey literature sources (n = 4). Findings indicated that KBs performed a diverse range of tasks across multiple health-related settings; results supported the KB role as a 'knowledge manager', 'linkage agent', and 'capacity builder'. Our systematic review explored outcome data from a subset of studies (n = 8) for evidence of changes in knowledge, skills, and policies or practices related to knowledge brokering. Two studies met standards for

  2. Patient knowledge, perceptions, and acceptance of generic medicines: a comprehensive review of the current literature

    Directory of Open Access Journals (Sweden)

    Alrasheedy AA

    2014-04-01

    Full Text Available Alian A Alrasheedy,1 Mohamed Azmi Hassali,1 Kay Stewart,2 David CM Kong,2 Hisham Aljadhey,3 Mohamed Izham Mohamed Ibrahim,4 Saleh Karamah Al-Tamimi1 1Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia; 2Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia; 3Medication Safety Research Chair, Clinical Pharmacy Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 4College of Pharmacy, Qatar University, Doha, Qatar Background: Generic medicines have the same quality, safety, and efficacy as their counterpart original brand medicines. Generic medicines provide the same therapeutic outcomes but at a much cheaper cost, so are promoted in many countries to contain pharmaceutical expenditure and sustain the health care system. Thus, the perspective of patients and medicine consumers as end users of these medicines is an important factor to enhance the use and utilization of generic medicines. The objective of this paper is to review patients’ and consumers’ knowledge, perceptions, acceptance, and views of generic medicines in the current literature. Methods: An extensive literature search was performed in several databases, namely Scopus, PubMed, ISI Web of Knowledge, Proquest, and the Wiley online library, to identify relevant studies published in the English literature for the period 1990–2013. Results: A total of 53 studies were included in the review, comprising 24 studies from Europe, ten from North America, six from Asia, five from Australia and New Zealand, five from the Middle East, one from Africa, one from Latin America, and one from the Caribbean region. A large body of literature has reported misconceptions and negative perceptions about generic medicines on the part of patients and medicine consumers. Moreover, although it is reported in almost all countries, the percentage of consumers who had

  3. Humpback Dolphins of Western Australia: A Review of Current Knowledge and Recommendations for Future Management.

    Science.gov (United States)

    Hanf, Daniella M; Hunt, Tim; Parra, Guido J

    2016-01-01

    Among the many cetacean species that occupy Australian coastal waters, Australian humpback dolphins, Sousa sahulensis, are one of the most vulnerable to extirpation due to human activities. This review summarises the existing knowledge, presently occurring and planned research projects, and current conservation measures for humpback dolphins in Western Australia (WA). Rapid and wide-scale coastal development along the northern WA coastline has occurred despite a lack of baseline data for inshore dolphins and, therefore, without a precautionary approach to their conservation. The distribution, abundance, habitat use, and population structure of humpback dolphins remain poorly understood. Less than 1% of their inferred distribution has so far been studied to understand local population demography. The sparse data available suggest that WA humpback dolphins occur as localised populations in low numbers within a range of inshore habitats, including both clear and turbid coastal waters. Marine protected areas cover a third of their inferred distribution in WA, but the efficacy of these reserves in protecting local cetacean populations is unknown. There is a pressing need for coordination and collaboration among scientists, government agencies, industry bodies, Traditional Owners, and local community groups to fill in the gaps of information on humpback dolphins in WA. The recently developed strategies and sampling guidelines developed by state and federal governments should serve as a best practise standard for collection of data aimed at assessing the conservation status of humpback dolphins in WA and Australia. © 2016 Elsevier Ltd. All rights reserved.

  4. The iron-sulfur cluster assembly machineries in plants: current knowledge and open questions

    Science.gov (United States)

    Couturier, Jérémy; Touraine, Brigitte; Briat, Jean-François; Gaymard, Frédéric; Rouhier, Nicolas

    2013-01-01

    Many metabolic pathways and cellular processes occurring in most sub-cellular compartments depend on the functioning of iron-sulfur (Fe-S) proteins, whose cofactors are assembled through dedicated protein machineries. Recent advances have been made in the knowledge of the functions of individual components through a combination of genetic, biochemical and structural approaches, primarily in prokaryotes and non-plant eukaryotes. Whereas most of the components of these machineries are conserved between kingdoms, their complexity is likely increased in plants owing to the presence of additional assembly proteins and to the existence of expanded families for several assembly proteins. This review focuses on the new actors discovered in the past few years, such as glutaredoxin, BOLA and NEET proteins as well as MIP18, MMS19, TAH18, DRE2 for the cytosolic machinery, which are integrated into a model for the plant Fe-S cluster biogenesis systems. It also discusses a few issues currently subjected to an intense debate such as the role of the mitochondrial frataxin and of glutaredoxins, the functional separation between scaffold, carrier and iron-delivery proteins and the crosstalk existing between different organelles. PMID:23898337

  5. Current Knowledge on the Use of Computational Toxicology in Hazard Assessment of Metallic Engineered Nanomaterials

    Directory of Open Access Journals (Sweden)

    Guangchao Chen

    2017-07-01

    Full Text Available As listed by the European Chemicals Agency, the three elements in evaluating the hazards of engineered nanomaterials (ENMs include the integration and evaluation of toxicity data, categorization and labeling of ENMs, and derivation of hazard threshold levels for human health and the environment. Assessing the hazards of ENMs solely based on laboratory tests is time-consuming, resource intensive, and constrained by ethical considerations. The adoption of computational toxicology into this task has recently become a priority. Alternative approaches such as (quantitative structure–activity relationships ((QSAR and read-across are of significant help in predicting nanotoxicity and filling data gaps, and in classifying the hazards of ENMs to individual species. Thereupon, the species sensitivity distribution (SSD approach is able to serve the establishment of ENM hazard thresholds sufficiently protecting the ecosystem. This article critically reviews the current knowledge on the development of in silico models in predicting and classifying the hazard of metallic ENMs, and the development of SSDs for metallic ENMs. Further discussion includes the significance of well-curated experimental datasets and the interpretation of toxicity mechanisms of metallic ENMs based on reported models. An outlook is also given on future directions of research in this frontier.

  6. Current Knowledge on the Use of Computational Toxicology in Hazard Assessment of Metallic Engineered Nanomaterials.

    Science.gov (United States)

    Chen, Guangchao; Peijnenburg, Willie; Xiao, Yinlong; Vijver, Martina G

    2017-07-12

    As listed by the European Chemicals Agency, the three elements in evaluating the hazards of engineered nanomaterials (ENMs) include the integration and evaluation of toxicity data, categorization and labeling of ENMs, and derivation of hazard threshold levels for human health and the environment. Assessing the hazards of ENMs solely based on laboratory tests is time-consuming, resource intensive, and constrained by ethical considerations. The adoption of computational toxicology into this task has recently become a priority. Alternative approaches such as (quantitative) structure-activity relationships ((Q)SAR) and read-across are of significant help in predicting nanotoxicity and filling data gaps, and in classifying the hazards of ENMs to individual species. Thereupon, the species sensitivity distribution (SSD) approach is able to serve the establishment of ENM hazard thresholds sufficiently protecting the ecosystem. This article critically reviews the current knowledge on the development of in silico models in predicting and classifying the hazard of metallic ENMs, and the development of SSDs for metallic ENMs. Further discussion includes the significance of well-curated experimental datasets and the interpretation of toxicity mechanisms of metallic ENMs based on reported models. An outlook is also given on future directions of research in this frontier.

  7. Influence of Electric, Magnetic, and Electromagnetic Fields on the Circadian System: Current Stage of Knowledge

    Science.gov (United States)

    Żak, Arkadiusz

    2014-01-01

    One of the side effects of each electrical device work is the electromagnetic field generated near its workplace. All organisms, including humans, are exposed daily to the influence of different types of this field, characterized by various physical parameters. Therefore, it is important to accurately determine the effects of an electromagnetic field on the physiological and pathological processes occurring in cells, tissues, and organs. Numerous epidemiological and experimental data suggest that the extremely low frequency magnetic field generated by electrical transmission lines and electrically powered devices and the high frequencies electromagnetic radiation emitted by electronic devices have a potentially negative impact on the circadian system. On the other hand, several studies have found no influence of these fields on chronobiological parameters. According to the current state of knowledge, some previously proposed hypotheses, including one concerning the key role of melatonin secretion disruption in pathogenesis of electromagnetic field induced diseases, need to be revised. This paper reviews the data on the effect of electric, magnetic, and electromagnetic fields on melatonin and cortisol rhythms—two major markers of the circadian system as well as on sleep. It also provides the basic information about the nature, classification, parameters, and sources of these fields. PMID:25136557

  8. Epidemiology of leishmaniasis in Ecuador: current status of knowledge - A review

    Directory of Open Access Journals (Sweden)

    Manuel Calvopina

    2004-11-01

    Full Text Available Although leishmaniasis is regarded as a significant health problem in Ecuador by the Ministry of Health, and the incidence has increased over the last years, an official map on the geographic distribution of disease and sand fly vectors or a control strategy do not exist yet. This article reviews the current situation based on published information to improve our knowledge and understand the epidemiological situation of leishmaniasis in Ecuador in order to help future research and to develop a national control strategy. The disease is endemic in most provinces throughout Pacific coastal region, Amazonian lowlands, and some inter-Andean valleys with a total 21,805 cases reported during 1990-2003. Whereas cutaneous leishmaniasis (CL is found throughout Ecuador, mucocutaneous leishmaniasis (MCL appears to be restricted to the Amazon region; one, parasitologically unconfirmed case of visceral form was reported in 1949. Most human infections are caused by Leishmania (Viannia spp., which is distributed in the subtropical and tropical lowlands; infections due to L. (Leishmania spp. are found in the Andean highlands and in the Pacific lowlands as well. The proven vectors are Lutzomyia trapidoi and Lu. ayacuchensis. Canis familiaris, Sciurus vulgaris, Potos flavus, and Tamandua tetradactyla have been found infected with Leishmania spp. It is estimated that around 3000-4500 people may be infected every year, and that 3.1 to 4.5 millions people are estimated to be at risk of contracting leishmaniasis.

  9. Current knowledge of microRNA-mediated regulation of drug metabolism in humans.

    Science.gov (United States)

    Nakano, Masataka; Nakajima, Miki

    2018-05-01

    Understanding the factors causing inter- and intra-individual differences in drug metabolism potencies is required for the practice of personalized or precision medicine, as well as for the promotion of efficient drug development. The expression of drug-metabolizing enzymes is controlled by transcriptional regulation by nuclear receptors and transcriptional factors, epigenetic regulation, such as DNA methylation and histone acetylation, and post-translational modification. In addition to such regulation mechanisms, recent studies revealed that microRNAs (miRNAs), endogenous ~22-nucleotide non-coding RNAs that regulate gene expression through the translational repression and degradation of mRNAs, significantly contribute to post-transcriptional regulation of drug-metabolizing enzymes. Areas covered: This review summarizes the current knowledge regarding miRNAs-dependent regulation of drug-metabolizing enzymes and transcriptional factors and its physiological and clinical significance. We also describe recent advances in miRNA-dependent regulation research, showing that the presence of pseudogenes, single-nucleotide polymorphisms, and RNA editing affects miRNA targeting. Expert opinion: It is unwavering fact that miRNAs are critical factors causing inter- and intra-individual differences in the expression of drug-metabolizing enzymes. Consideration of miRNA-dependent regulation would be a helpful tool for optimizing personalized and precision medicine.

  10. SMAD family proteins: the current knowledge on their expression and potential role in neoplastic diseases

    Directory of Open Access Journals (Sweden)

    Magdalena Witkowska

    2014-03-01

    Full Text Available Transforming growth factor beta (TGF-β plays a crucial role and takes part in many processes in the human body both in physiology and pathology. This cytokine is involved in angiogenesis, regulates apoptosis and stimulates divisions of cells, such as hepatocytes, lymphocytes or hematopoietic cells. SMAD proteins family is a unique group of particles responsible for transducting the signal induced by TGF-β into the nucleus. This molecules, after receiving a signal from activated TGF-β, act on transcription factors in the nucleus, leading directly to the expression of the corresponding genes. According to current knowledge, disturbances in the functioning of SMAD proteins are present in a number of diseases. The reduced expression was observed, for example in cardiovascular diseases such as primary pulmonary hypertension or myocardial infarction, autoimmune diseases for instance systemic lupus erythematosus and multiple sclerosis, Alzheimer’s disease or osteoporosis. The latest clinical data showed the presence of mutations in SMAD proteins in cancerogenesis. Mutation of SMAD-4 protein can be detected in half of the patients with pancreatic cancer, 20% of patients with colorectal cancer and 10% of patients with lung cancer. However, mutation in SMAD-2 protein was observed in 7% of both patients with colorectal cancer and lung cancer. On the basis of numerous works, SMAD protein expression would be valuable prognostic factor in some of neoplastic diseases.

  11. Use of a web site to increase knowledge and awareness of hunger-related issues.

    Science.gov (United States)

    Jennings, Sharla; Cotugna, Nancy; Vickery, Connie E

    2003-11-01

    The purpose of this study was to determine the current level of knowledge and awareness of hunger-related issues among a convenience sample of Delawareans. We also assessed whether raising knowledge and awareness of the hunger problem through the FBD's newly designed web site would encourage participation in antihunger activities. Via e-mail, 1,719 individuals were invited to participate in a three-phase, online survey, and 392 agreed. Phase-I questions were answered prior to viewing the web site, phase II (n=217) immediately afterward, and phase III (n=61) six weeks later. Responses indicated a high level of awareness about general hunger issues but specific knowledge proved to be at a lower level. No statistically significant differences were noted when data were collapsed across gender, age, educational level, or work setting. In a six-week post-survey, 41% of subjects were motivated by the web site to engage in an antihunger activity; 34% had told others about the web site and indicated it may be a useful tool in antihunger outreach efforts for the FBD.

  12. Use of a web site to increase knowledge and awareness of hunger-related issues.

    Science.gov (United States)

    Jennings, Sharla; Cotugna, Nancy; Vickery, Connie E.

    2003-01-01

    The purpose of this study was to determine the current level of knowledge and awareness of hunger-related issues among a convenience sample of Delawareans. We also assessed whether raising knowledge and awareness of the hunger problem through the FBD's newly designed web site would encourage participation in antihunger activities. Via e-mail, 1,719 individuals were invited to participate in a three-phase, online survey, and 392 agreed. Phase-I questions were answered prior to viewing the web site, phase II (n=217) immediately afterward, and phase III (n=61) six weeks later. Responses indicated a high level of awareness about general hunger issues but specific knowledge proved to be at a lower level. No statistically significant differences were noted when data were collapsed across gender, age, educational level, or work setting. In a six-week post-survey, 41% of subjects were motivated by the web site to engage in an antihunger activity; 34% had told others about the web site and indicated it may be a useful tool in antihunger outreach efforts for the FBD. PMID:14651376

  13. How Do Clinicians Learn About Knowledge Translation? An Investigation of Current Web-Based Learning Opportunities.

    Science.gov (United States)

    Damarell, Raechel A; Tieman, Jennifer J

    2017-07-13

    Clinicians are important stakeholders in the translation of well-designed research evidence into clinical practice for optimal patient care. However, the application of knowledge translation (KT) theories and processes may present conceptual and practical challenges for clinicians. Online learning platforms are an effective means of delivering KT education, providing an interactive, time-efficient, and affordable alternative to face-to-face education programs. This study investigates the availability and accessibility of online KT learning opportunities for health professionals. It also provides an analysis of the types of resources and associated disciplines retrieved by a range of KT synonyms. We searched a range of bibliographic databases and the Internet (Google advanced option) using 9 KT terms to identify online KT learning resources. To be eligible, resources had to be free, aimed at clinicians, educational in intent, and interactive in design. Each term was searched using two different search engines. The details of the first 100 websites captured per browser (ie, n=200 results per term) were entered into EndNote. Each site was subsequently visited to determine its status as a learning resource. Eligible websites were appraised for quality using the AACODS (Authority, Accuracy, Coverage, Objectivity, Date, Significance) tool. We identified 971 unique websites via our multiple search strategies. Of these, 43 were health-related and educational in intent. Once these sites were evaluated for interactivity, a single website matched our inclusion criteria (Dementia Knowledge Translation Learning Centre). KT is an important but complex system of processes. These processes overlap with knowledge, practice, and improvement processes that go by a range of different names. For clinicians to be informed and competent in KT, they require better access to free learning opportunities. These resources should be designed from the viewpoint of the clinician, presenting KT

  14. Biogenic volatile organic compound emissions from the Eurasian taiga: current knowledge and future directions

    Energy Technology Data Exchange (ETDEWEB)

    Rinne, J. (Dept. of Physics, Univ. of Helsinki (Finland)); Baeck, J. (Dept. of Forest Ecology, Univ. of Helsinki (Finland)); Hakola, H. (Finnish Meteorological Institute, Air Quality Research, Helsinki (Finland))

    2009-07-01

    n this paper, the research conducted on the emissions of the biogenic volatile organic compounds (BVOCs) from the European boreal zone, or taiga, is reviewed. We highlight the main findings and the key gaps in our knowledge. Ecosystem scale BVOC emissions from the Eurasian taiga are observed to be relatively low as compared with those from some forest ecosystems in warmer climates. One of the distinctive features of the Eurasian taiga is the predominance of monoterpene emitting coniferous trees. Recent research indicates that in addition to evaporation from storage structures, part of the monoterpene emission of conifers originates directly from synthesis. Monoterpene emission from boreal deciduous trees originates mainly directly from synthesis. The boreal trees exhibit distinct intra-species variation in the monoterpene mixtures they emit. Important sources of isoprene in the Eurasian taiga include Norway spruce, open wetland ecosystems and some non-dominant woody species, such as European aspen and willows. Many boreal tree species also emit non-terpenoid compounds and highly reactive sesquiterpenes. The future challenges in the research on BVOC emissions from the Eurasian taiga include (i) quantification and understanding the non-terpenoid VOC emissions from the taiga ecosystems, (ii) bringing ecosystems in the eastern Eurasian taiga into the sphere of BVOC emission studies, (iii) establishing long-term ecosystem flux studies combined with plant physiological measurements, and (iv) integrating knowledge and research skills on BVOC synthesis, storages and emissions, land cover changes and atmospheric processes in different spatial and temporal scales in order to better understand the impact of biosphere on atmospheric chemistry and composition in changing climate. (orig.)

  15. The advertisement calls of Brazilian anurans: Historical review, current knowledge and future directions.

    Science.gov (United States)

    Guerra, Vinicius; Llusia, Diego; Gambale, Priscilla Guedes; Morais, Alessandro Ribeiro de; Márquez, Rafael; Bastos, Rogério Pereira

    2018-01-01

    Advertisement calls are often used as essential basic information in studies of animal behaviour, ecology, evolution, conservation, taxonomy or biodiversity inventories. Yet the description of this type of acoustic signals is far to be completed, especially in tropical regions, and is frequently non-standardized or limited in information, restricting the application of bioacoustics in science. Here we conducted a scientometric review of the described adverstisement calls of anuran species of Brazil, the world richest territory in anurans, to evaluate the amount, standard and trends of the knowledge on this key life-history trait and to identify gaps and directions for future research strategies. Based on our review, 607 studies have been published between 1960 to 2016 describing the calls of 719 Brazilian anuran species (68.8% of all species), a publication rate of 10.6 descriptions per year. From each of these studies, thirty-one variables were recorded and examined with descriptive and inferential statistics. In spite of an exponential rise over the last six decades in the number of studies, described calls, and quantity of published metadata, as revealed by regression models, clear shortfalls were identified with regard to anuran families, biomes, and categories of threat. More than 55% of these species belong to the two richest families, Hylidae or Leptodactylidae. The lowest percentage of species with described calls corresponds to the most diverse biomes, namely Atlantic Forest (65.1%) and Amazon (71.5%), and to the IUCN categories of threat (56.8%), relative to the less-than-threatened categories (74.3%). Moreover, only 52.3% of the species have some of its calls deposited in the main scientific sound collections. Our findings evidence remarkable knowledge gaps on advertisement calls of Brazilian anuran species, emphasizing the need of further efforts in standardizing and increasing the description of anuran calls for their application in studies of the

  16. The advertisement calls of Brazilian anurans: Historical review, current knowledge and future directions.

    Directory of Open Access Journals (Sweden)

    Vinicius Guerra

    Full Text Available Advertisement calls are often used as essential basic information in studies of animal behaviour, ecology, evolution, conservation, taxonomy or biodiversity inventories. Yet the description of this type of acoustic signals is far to be completed, especially in tropical regions, and is frequently non-standardized or limited in information, restricting the application of bioacoustics in science. Here we conducted a scientometric review of the described adverstisement calls of anuran species of Brazil, the world richest territory in anurans, to evaluate the amount, standard and trends of the knowledge on this key life-history trait and to identify gaps and directions for future research strategies. Based on our review, 607 studies have been published between 1960 to 2016 describing the calls of 719 Brazilian anuran species (68.8% of all species, a publication rate of 10.6 descriptions per year. From each of these studies, thirty-one variables were recorded and examined with descriptive and inferential statistics. In spite of an exponential rise over the last six decades in the number of studies, described calls, and quantity of published metadata, as revealed by regression models, clear shortfalls were identified with regard to anuran families, biomes, and categories of threat. More than 55% of these species belong to the two richest families, Hylidae or Leptodactylidae. The lowest percentage of species with described calls corresponds to the most diverse biomes, namely Atlantic Forest (65.1% and Amazon (71.5%, and to the IUCN categories of threat (56.8%, relative to the less-than-threatened categories (74.3%. Moreover, only 52.3% of the species have some of its calls deposited in the main scientific sound collections. Our findings evidence remarkable knowledge gaps on advertisement calls of Brazilian anuran species, emphasizing the need of further efforts in standardizing and increasing the description of anuran calls for their application in

  17. Current Trends in Sustainability of Bitcoins and Related Blockchain Technology

    Directory of Open Access Journals (Sweden)

    Pasquale Giungato

    2017-11-01

    Full Text Available Bitcoin is a digital currency based on a peer-to-peer payment system managed by an open source software and characterized by lower transaction costs, greater security and scalability than fiat money and no need of a central bank. Despite criticisms about illegal uses and social consequences, it is attracting the interest of the scientific community. The purpose of this work is to define and evaluate the current trends of the literature concerned with the sustainability of bitcoin, considering the environmental impacts, social issues and economic aspects. From the analysis it emerges that the transition of the whole monetary system in the new cryptocurrency will result in an unacceptable amount of energy consumed to mine new bitcoins and to maintain the entire virtual monetary system, and probably bitcoin will remain a niche currency. Blockchain, which is the base for a distributed and democratically-sustained public ledger of the transactions, could foster new and challenging opportunities. Sharing the framework of medical data, energy generation and distribution in micro-grids at the citizen level, block-stack and new state-driven cryptocurrencies, may benefit from the wide spread of blockchain-based transactions. Under the perspective of its being a driver of social change, bitcoins and related blockchain technologies may overcome the issues highlighted by numerous detractors.

  18. Sports-related concussions: diagnosis, complications, and current management strategies.

    Science.gov (United States)

    Hobbs, Jonathan G; Young, Jacob S; Bailes, Julian E

    2016-04-01

    Sports-related concussions (SRCs) are traumatic events that affect up to 3.8 million athletes per year. The initial diagnosis and management is often instituted on the field of play by coaches, athletic trainers, and team physicians. SRCs are usually transient episodes of neurological dysfunction following a traumatic impact, with most symptoms resolving in 7-10 days; however, a small percentage of patients will suffer protracted symptoms for years after the event and may develop chronic neurodegenerative disease. Rarely, SRCs are associated with complications, such as skull fractures, epidural or subdural hematomas, and edema requiring neurosurgical evaluation. Current standards of care are based on a paradigm of rest and gradual return to play, with decisions driven by subjective and objective information gleaned from a detailed history and physical examination. Advanced imaging techniques such as functional MRI, and detailed understanding of the complex pathophysiological process underlying SRCs and how they affect the athletes acutely and long-term, may change the way physicians treat athletes who suffer a concussion. It is hoped that these advances will allow a more accurate assessment of when an athlete is truly safe to return to play, decreasing the risk of secondary impact injuries, and provide avenues for therapeutic strategies targeting the complex biochemical cascade that results from a traumatic injury to the brain.

  19. Consumer attitudes, knowledge, and behavior related to salt consumption in sentinel countries of the Americas.

    Science.gov (United States)

    Claro, Rafael Moreira; Linders, Hubert; Ricardo, Camila Zancheta; Legetic, Branka; Campbell, Norm R C

    2012-10-01

    To describe individual attitudes, knowledge, and behavior regarding salt intake, its dietary sources, and current food-labeling practices related to salt and sodium in five sentinel countries of the Americas. A convenience sample of 1 992 adults (≥ 18 years old) from Argentina, Canada, Chile, Costa Rica, and Ecuador (approximately 400 from each country) was obtained between September 2010 and February 2011. Data collection was conducted in shopping malls or major commercial areas using a questionnaire containing 33 questions. Descriptive estimates are presented for the total sample and stratified by country and sociodemographic characteristics of the studied population. Almost 90% of participants associated excess intake of salt with the occurrence of adverse health conditions, more than 60% indicated they were trying to reduce their current intake of salt, and more than 30% believed reducing dietary salt to be of high importance. Only 26% of participants claimed to know the existence of a recommended maximum value of salt or sodium intake and 47% of them stated they knew the content of salt in food items. More than 80% of participants said that they would like food labeling to indicate high, medium, and low levels of salt or sodium and would like to see a clear warning label on packages of foods high in salt. Additional effort is required to increase consumers' knowledge about the existence of a maximum limit for intake and to improve their capacity to accurately monitor and reduce their personal salt consumption.

  20. Knowledge, opinions and practices of healthcare workers related to infant feeding in the context of HIV

    Directory of Open Access Journals (Sweden)

    Liska Janse van Rensburg

    2016-12-01

    Conclusion: Healthcare workers' knowledge did not conform favourably with the current WHO guidelines. These healthcare workers were actively involved in the care of patients in the maternity wards where HIV-infected mothers regularly seek counselling on infant feeding matters.

  1. Knowledge, attitudes and behaviours of adolescents in relation to ...

    African Journals Online (AJOL)

    ... in relation to STIs, pregnancy, contraceptive utilization and substance abuse in ... alcohol and drug abuse, is of grave concern, especially its impact among the ... Of the young women, 12.8% reported to have fallen pregnant with one-sixth of ...

  2. A Case Analysis to Increase Awareness of Current USMC Knowledge Management (KM) Practices

    Science.gov (United States)

    2013-09-01

    Knowledge Management System KPI Key Performance Indicator KS Knowledge Superiority KVA Knowledge Value Added MAGTF Marine Air Ground Task Force...quantitative KPIs [key performance indicators] developed to monitor efficiency and some qualitative KPIs to assess effectiveness in the implementation...integration,” and the level of control is “qualitative and quantitative KPIs in place to monitor the implementation of an effective and efficient KM

  3. Probing modifications of general relativity using current cosmological observations

    International Nuclear Information System (INIS)

    Zhao Gongbo; Bacon, David J.; Koyama, Kazuya; Nichol, Robert C.; Song, Yong-Seon; Giannantonio, Tommaso; Pogosian, Levon; Silvestri, Alessandra

    2010-01-01

    We test general relativity (GR) using current cosmological data: the CMB from WMAP5 [E. Komatsu et al. (WMAP Collaboration), Astrophys. J. Suppl. Ser. 180, 330 (2009)], the integrated Sachs-Wolfe (ISW) effect from the cross correlation of the CMB with six galaxy catalogs [T. Giannantonio et al., Phys. Rev. D 77, 123520 (2008)], a compilation of supernovae (SNe) type Ia including the latest Sloan Digital Sky Survey SNe [R. Kessler et al., Astrophys. J. Suppl. Ser. 185, 32 (2009).], and part of the weak lensing (WL) data from the Canada-Franco-Hawaii Telescope Legacy Survey [L. Fu et al., Astron. Astrophys. 479, 9 (2008); M. Kilbinger et al., Astron. Astrophys. 497, 677 (2009).] that probe linear and mildly nonlinear scales. We first test a model in which the effective Newtonian constant μ and the ratio of the two gravitational potentials, η, transit from the GR value to another constant at late times; in this case, we find that GR is fully consistent with the combined data. The strongest constraint comes from the ISW effect which would arise from this gravitational transition; the observed ISW signal imposes a tight constraint on a combination of μ and η that characterizes the lensing potential. Next, we consider four pixels in time and space for each function μ and η, and perform a principal component analysis, finding that seven of the resulting eight eigenmodes are consistent with GR within the errors. Only one eigenmode shows a 2σ deviation from the GR prediction, which is likely to be due to a systematic effect. However, the detection of such a deviation demonstrates the power of our time- and scale-dependent principal component analysis methodology when combining observations of structure formation and expansion history to test GR.

  4. Natural or Plant Products for the Treatment of Neurological Disorders: Current Knowledge.

    Science.gov (United States)

    Parvez, Mohammad Khalid

    2018-01-01

    In recent decades, complementary and alternative medicine (CAM) has become very popular in the treatment of several chronic diseases. Natural products as one of the CAM modalities offer potential opportunities to discover lead compounds for novel drug development. The use of CAM or natural products in the prevention of neurodegenerative diseases is comparatively a newer area. A structured online literature search for peer-reviewed research articles was conducted on the PubMed, Europe PMC, Medline and Google Scholar portals, using phrases: natural products for neurologic disorders, phytomedicine for neurodegenerative diseases, natural therapeutics for neurological symptopms etc. Results: The retrieved data showed the natural therapeutics with anti-oxidative and anti-inflammatory salutations evidently plays a crucial role in protecting neurons. Of these, the most promising are caffeine, trigonelline, shogaol, curcumin, resveratrol, baicalein, wogonin, ginsenosides, tanshinones, withanolides, picrosides, parthenolide, cannabinoids, Devil's claw and white willow bark, including Chinese formulations Renshen Shouwu and Shengmai San. Though several herbs and their active ingredients have been studied in laboratory and clinical settings, only a few have been investigated for their molecular mechanisms of action. Notably, despite the promising and safe therapeutic benefits of CAM/herbal medicines, there exists a possible risk when combining them with prescription drugs. As a result, many drugs have shown changes in blood pressure, hepatotoxicity, seizures etc. when combined with certain herbs. Certainly, extensive work is needed to make sure that patients should take a regimen of protective and restorative therapy under an experienced healthcare professional. This article updates on the current knowledge of promising natural products used in neurological disorders. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  5. Synthesis of current knowledge on post-fire seeding for soil stabilization and invasive species control

    Science.gov (United States)

    Beyers, Jan L.; Pyke, David A.; Wirth, Troy

    2015-01-01

    The General Accounting Office has identified a need for better information on the effectiveness of post-fire emergency stabilization and rehabilitation methods used by the U.S. Forest Service and Department of Interior (DOI) agencies. Since reviews were published on treatment effectiveness in the early 2000s, treatment choices have changed and increased monitoring has been done. Greater use of native species has added substantially to burned area emergency response (BAER) treatment costs, for example, but quantitative data on this treatment were scarce in earlier reviews. We synthesized current information on the effectiveness of post-fire seeding for both soil stabilization and for prevention of the spread of invasive species in rangelands. We reviewed published literature (peer-reviewed and “gray”) and agency monitoring reports, as well as compiled and analyzed quantitative data in agency files. Products of this review include a web-accessible database of monitoring reports and published information, a scientific journal paper summarizing findings of scientific studies, an annotated bibliography of peer-reviewed papers, a summary report published as a General Technical Report that will be available online (in progress), and presentations to scientific meetings and BAER/ESR team training sessions and workshops. By combining results from studies done by Forest Service and DOI agency personnel with research studies published since the initial reviews, we presented a comprehensive synthesis of seeding effectiveness knowledge that complements the review of other hillslope treatments published by other researchers. This information will help federal land managers make more cost-effective decisions on post-fire stabilization and rehabilitation treatments.

  6. Constructing regional advantage: platform policies based on related variety and differentiated knowledge bases.

    NARCIS (Netherlands)

    Asheim, B.T.; Boschma, R.A.; Cooke, P.

    2011-01-01

    Constructing regional advantage: platform policies based on related variety and differentiated knowledge bases, Regional Studies. This paper presents a regional innovation policy model based on the idea of constructing regional advantage. This policy model brings together concepts like related

  7. Transfusion-transmitted CMV infection - current knowledge and future perspectives.

    Science.gov (United States)

    Ziemann, M; Thiele, T

    2017-08-01

    Transmission of human cytomegalovirus (CMV) via transfusion (TT-CMV) may still occur and remains a challenge in the treatment of immunocompromised CMV-seronegative patients, e.g. after stem cell transplantation, and for low birthweight infants. Measures to reduce the risk of TT-CMV have been evaluated in clinical studies, including leucocyte depletion of cellular blood products and/or the selection of CMV-IgG-negative donations. Studies in large blood donor cohorts indicate that donations from newly CMV-IgG-positive donors should bear the highest risk for transmitting CMV infections because they contain the highest levels of CMV-DNA, and early CMV antibodies cannot neutralise CMV. Based on this knowledge, rational strategies to reduce the residual risk of TT-CMV using leucoreduced blood products could be designed. However, there is a lack of evidence that CMV is still transmitted by transfusion of leucoreduced units. In low birthweight infants, most (if not all) CMV infections are caused by breast milk feeding or congenital transmission rather than by transfusion of leucoreduced blood products. For other patients at risk, no definitive data exist about the relative importance of alternative transmission routes of CMV compared to blood transfusion. As a result, only the conduction of well-designed studies addressing strategies to prevent TT-CMV and the thorough examination of presumed cases of TT-CMV will achieve guidance for the best transfusion regimen in patients at risk. © 2017 British Blood Transfusion Society.

  8. Transport and Use of Bicarbonate in Plants: Current Knowledge and Challenges Ahead

    Directory of Open Access Journals (Sweden)

    Charlotte Poschenrieder

    2018-05-01

    Full Text Available Bicarbonate plays a fundamental role in the cell pH status in all organisms. In autotrophs, HCO3− may further contribute to carbon concentration mechanisms (CCM. This is especially relevant in the CO2-poor habitats of cyanobacteria, aquatic microalgae, and macrophytes. Photosynthesis of terrestrial plants can also benefit from CCM as evidenced by the evolution of C4 and Crassulacean Acid Metabolism (CAM. The presence of HCO3− in all organisms leads to more questions regarding the mechanisms of uptake and membrane transport in these different biological systems. This review aims to provide an overview of the transport and metabolic processes related to HCO3− in microalgae, macroalgae, seagrasses, and terrestrial plants. HCO3− transport in cyanobacteria and human cells is much better documented and is included for comparison. We further comment on the metabolic roles of HCO3− in plants by focusing on the diversity and functions of carbonic anhydrases and PEP carboxylases as well as on the signaling role of CO2/HCO3− in stomatal guard cells. Plant responses to excess soil HCO3− is briefly addressed. In conclusion, there are still considerable gaps in our knowledge of HCO3− uptake and transport in plants that hamper the development of breeding strategies for both more efficient CCM and better HCO3− tolerance in crop plants.

  9. Transport and Use of Bicarbonate in Plants: Current Knowledge and Challenges Ahead.

    Science.gov (United States)

    Poschenrieder, Charlotte; Fernández, José Antonio; Rubio, Lourdes; Pérez, Laura; Terés, Joana; Barceló, Juan

    2018-05-03

    Bicarbonate plays a fundamental role in the cell pH status in all organisms. In autotrophs, HCO₃ − may further contribute to carbon concentration mechanisms (CCM). This is especially relevant in the CO₂-poor habitats of cyanobacteria, aquatic microalgae, and macrophytes. Photosynthesis of terrestrial plants can also benefit from CCM as evidenced by the evolution of C₄ and Crassulacean Acid Metabolism (CAM). The presence of HCO₃ − in all organisms leads to more questions regarding the mechanisms of uptake and membrane transport in these different biological systems. This review aims to provide an overview of the transport and metabolic processes related to HCO₃ − in microalgae, macroalgae, seagrasses, and terrestrial plants. HCO₃ − transport in cyanobacteria and human cells is much better documented and is included for comparison. We further comment on the metabolic roles of HCO₃ − in plants by focusing on the diversity and functions of carbonic anhydrases and PEP carboxylases as well as on the signaling role of CO₂/HCO₃ − in stomatal guard cells. Plant responses to excess soil HCO₃ − is briefly addressed. In conclusion, there are still considerable gaps in our knowledge of HCO₃ − uptake and transport in plants that hamper the development of breeding strategies for both more efficient CCM and better HCO₃ − tolerance in crop plants.

  10. Developing a Knowledge Management Framework to Assist With Current USMC Information Management Practices

    Science.gov (United States)

    2010-09-01

    OF CONTENTS I. INTRODUCTION ........................................................................................................1 II. LITERATURE...LEFT BLANK 1 I. INTRODUCTION Marine Corps Information Management is performed in accordance with Marine Corps Warfighting Publication (MCWP) 3...November 13). Air Force Center of Excellence for Knowledge Mangement Briefing. Washington, D.C. Alavi, M., & Leidner, D. E. (2001). Review: Knowledge

  11. Assessment of nutrition knowledge and related aspects among first-year Kuwait University students.

    Science.gov (United States)

    El-Sabban, Farouk; Badr, Hanan E

    2011-01-01

    Assessing nutrition knowledge of populations assists in drawing strategies for education programs. Nutrition-related problems are common in Kuwait, thus data on nutrition knowledge are needed. This study involved administration of a questionnaire to 1,037 first-year Kuwait University students. The overall nutrition knowledge score was rated as fair, with deficiency in specific areas of knowledge. Students' dietary habits, attitudes, and interest in nutrition information were assessed as fair. Our findings will aid in building a nutrition knowledge database in Kuwait. A simplified course on aspects of healthy nutrition and lifestyle to all Kuwait University students is highly recommended.

  12. WATER AND HYGIENE IN THE KHARAA RIVER BASIN, MONGOLIA: CURRENT KNOWLEDGE AND RESEARCH NEEDS

    Directory of Open Access Journals (Sweden)

    D. Karthe

    2017-01-01

    Full Text Available The Kharaa River Basin has some of the highest densities of population, agricultural and industrial activities in Mongolia. This puts the naturally limited water resources under pressure in both a quantitative and qualitative perspective. Besides mining, key sources of surface water contamination include large numbers of livestock in riverine floodplains and the discharge of untreated or poorly treated waste waters, both into rivers and by soil infiltration. Since both shallow groundwater and river water are used by people and for livestock, there are at least theoretical risks related to the transmission of water-borne pathogens. Only a very limited number of studies on water and hygiene have so far been conducted in Mongolia, all indicating (potential risks to water users. However, a lack of current and reliable water microbiology data leads to the need of systematic screening of water hygiene in order to derive conclusions for public health and drinking water management at the local and regional scale.

  13. Current knowledge and potential applications of cavitation technologies for the petroleum industry.

    Science.gov (United States)

    Avvaru, Balasubrahmanyam; Venkateswaran, Natarajan; Uppara, Parasuveera; Iyengar, Suresh B; Katti, Sanjeev S

    2018-04-01

    Technologies based on cavitation, produced by either ultrasound or hydrodynamic means, are part of growing literature for individual refinery unit processes. In this review, we have explained the mechanism through which these cavitation technologies intensify individual unit processes such as enhanced oil recovery, demulsification of water in oil emulsions during desalting stage, crude oil viscosity reduction, oxidative desulphurisation/demetallization, and crude oil upgrading. Apart from these refinery processes, applications of this technology are also mentioned for other potential crude oil sources such as oil shale and oil sand extraction. The relative advantages and current situation of each application/process at commercial scale is explained. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Trend of environmental radiation protection and its current related studies

    International Nuclear Information System (INIS)

    Yoshida, Satoshi

    2011-01-01

    -coverage expression profiling) developed in NIRS gives gamma-ray responding multiple genes of a springtail and fresh water algae. The project STAR (Strategy for Allied Radioecology) started from this year in Europe is worth to watch. In Japan, ERP issues will be more eagerly discussed hereafter in relation to working of a large scale fuel reprocessing facility, region of deep geological repository of radioactive wastes and current problems in Fukushima Power Station. (T.T.)

  15. Community Knowledge about Water: Who Has Better Knowledge and Is This Associated with Water-Related Behaviors and Support for Water-Related Policies?

    Directory of Open Access Journals (Sweden)

    Angela J Dean

    Full Text Available Sustainable approaches to water management require broad community acceptance of changes in policy, practice and technology, which in turn, requires an engaged community. A critical first step in building an engaged community is to identify community knowledge about water management, an issue rarely examined in research. To address this, we surveyed a representative sample of Australian adults (n = 5172. Knowledge was assessed using 15 questions about impact of household activities on waterways, the urban water cycle, and water management. This survey also examined demographics, psychosocial characteristics, exposure to water-related information, and water-related behaviors and policy support. Participants correctly answered a mean of 8.0 questions (Range 0-15. Most respondents knew that household actions can reduce water use and influence waterway health, whereas less than one third correctly identified that domestic wastewater is treated prior to entering waterways, urban stormwater is not treated, and that these are carried via different pipes. Higher water knowledge was associated with older age, higher education and living in non-urban areas. Poorer water knowledge was associated with speaking a language other than English in the home. Garden size, experience of water restrictions, satisfaction, waterway use for swimming, and certain information sources were also associated with knowledge. Greater water knowledge was associated with adoption of water-saving and pollution-reduction behaviors, and support for both alternative water sources and raingardens. These findings confirm the importance of community knowledge, and identify potential subgroups who may require additional targeting to build knowledge and support for water management initiatives.

  16. Community Knowledge about Water: Who Has Better Knowledge and Is This Associated with Water-Related Behaviors and Support for Water-Related Policies?

    Science.gov (United States)

    Dean, Angela J; Fielding, Kelly S; Newton, Fiona J

    2016-01-01

    Sustainable approaches to water management require broad community acceptance of changes in policy, practice and technology, which in turn, requires an engaged community. A critical first step in building an engaged community is to identify community knowledge about water management, an issue rarely examined in research. To address this, we surveyed a representative sample of Australian adults (n = 5172). Knowledge was assessed using 15 questions about impact of household activities on waterways, the urban water cycle, and water management. This survey also examined demographics, psychosocial characteristics, exposure to water-related information, and water-related behaviors and policy support. Participants correctly answered a mean of 8.0 questions (Range 0-15). Most respondents knew that household actions can reduce water use and influence waterway health, whereas less than one third correctly identified that domestic wastewater is treated prior to entering waterways, urban stormwater is not treated, and that these are carried via different pipes. Higher water knowledge was associated with older age, higher education and living in non-urban areas. Poorer water knowledge was associated with speaking a language other than English in the home. Garden size, experience of water restrictions, satisfaction, waterway use for swimming, and certain information sources were also associated with knowledge. Greater water knowledge was associated with adoption of water-saving and pollution-reduction behaviors, and support for both alternative water sources and raingardens. These findings confirm the importance of community knowledge, and identify potential subgroups who may require additional targeting to build knowledge and support for water management initiatives.

  17. Knowledge of breast density and awareness of related breast cancer risk.

    Science.gov (United States)

    Manning, Mark A; Duric, Neb; Littrup, Peter; Bey-Knight, Lisa; Penner, Louis; Albrecht, Terrance L

    2013-06-01

    Little is known about women's knowledge of breast density or between-race differences in this knowledge. In the current study, we examined knowledge of breast density and awareness of its role as a breast cancer risk factor among women who had previously taken part in a breast imaging study. Seventy-seven women (54.5 % Black) returned a survey assessing perceptions and accuracy of breast density knowledge, knowledge of one's own breast density, and breast cancer risk awareness. White women had greater perceived knowledge of breast density compared to Black women; however, differences in the accuracy of definitions of breast density were due to education. Black women were less likely to know how dense their own breasts were. Black and White women both lacked awareness that having dense breast increased breast cancer risk. The results highlight the need to disseminate information regarding breast density to women, while ensuring that the information is equally accessible to both Black and White women.

  18. Current state of knowledge in microbial degradation of polycyclic aromatic hydrocarbons (PAHs: a review

    Directory of Open Access Journals (Sweden)

    Debajyoti Ghosal

    2016-08-01

    PAHs. The main purpose of this review is to provide an overview of current knowledge of bacteria, halophilic archaea, fungi and algae mediated degradation/transformation of PAHs. In addition, factors affecting PAHs degradation in the environment, recent advancement in genetic, genomic, proteomic and metabolomic techniques are also highlighted with an aim to facilitate the development of a new insight into the bioremediation of PAH in the environment.

  19. Current State of Knowledge in Microbial Degradation of Polycyclic Aromatic Hydrocarbons (PAHs): A Review

    Science.gov (United States)

    Ghosal, Debajyoti; Ghosh, Shreya; Dutta, Tapan K.; Ahn, Youngho

    2016-01-01

    purpose of this review is to provide an overview of current knowledge of bacteria, halophilic archaea, fungi and algae mediated degradation/transformation of PAHs. In addition, factors affecting PAHs degradation in the environment, recent advancement in genetic, genomic, proteomic and metabolomic techniques are also highlighted with an aim to facilitate the development of a new insight into the bioremediation of PAH in the environment. PMID:27630626

  20. Skin Wound Healing: An Update on the Current Knowledge and Concepts.

    Science.gov (United States)

    Sorg, Heiko; Tilkorn, Daniel J; Hager, Stephan; Hauser, Jörg; Mirastschijski, Ursula

    2017-01-01

    repair have been delineated in part, many underlying pathophysiological processes are still unknown. The purpose of the following update on skin wound healing is to focus on the different phases and to brief the reader on the current knowledge and new insights. Skin wound healing is a complex process, which is dependent on many cell types and mediators interacting in a highly sophisticated temporal sequence. Although some interactions during the healing process are crucial, redundancy is high and other cells or mediators can adopt functions or signaling without major complications. © 2016 S. Karger AG, Basel.

  1. Comparison of knowledge of and attitudes toward dementia between health-related and non-health-related university students.

    Science.gov (United States)

    Yong, Mi-Hyun; Yoo, Chan-Uk; Yang, Yeong-Ae

    2015-12-01

    [Purpose] This study compared the knowledge of and attitudes toward dementia between health-related and non-health-related students. [Subjects] The subjects consisted of a total of 416 people, 213 health-related students and 203 non-health-related students, at K University, which is located in Gyeongsangbuk-do, Republic of Korea, between May 1 and 14, 2014. [Methods] The subjects answered a self-administered questionnaire about their knowledge of and attitudes toward dementia. [Results] There was a significant difference in knowledge of and attitudes toward dementia between the two groups examined. [Conclusion] Health-related students displayed higher knowledge of dementia and a more positive attitude toward dementia compared with non-health-related students. In the future, education to cultivate professional knowledge about dementia and enhance positive attitudes toward dementia should be provided continuously to health-related students. This is because students in health-related fields will likely provide services to patients with dementia in the clinical field. Additionally, as they will likely provide support to the elderly in the future, non-health-related students also need to be educated about and develop positive attitudes toward dementia.

  2. Current clinical research of immunoglobulin G4-related orbital disease

    Directory of Open Access Journals (Sweden)

    Yang Wang

    2016-05-01

    Full Text Available Immunoglobulin G4-related disease(IgG4-related diseasehas received lots of attention in medical community as a recently recognized fibro-inflammatory condition. It is characterized by infiltration of IgG4-immunopositive plasmacytes and concentration of elevated serum IgG4. IgG4-related disease shows organ enlargement or nodular/hyperplastic lesions in various organs including the pancreas, hepatobiliary tract and orbit, which is called IgG4-related orbital disease. The diagnostic criteria for IgG4-related disease and IgG4-related orbital disease has recently been established, which is based on clinical, imaging and histopathologic features of the orbital lesions. Besides, attention should be drawn to the differentiation from other diseases. The treatment is empirical including corticosteroids, immunosuppressive drugs, radiotherapy, and rituximab. This article reviews clinical progression of IgG4-related orbital disease.

  3. Age-related variations of visuo-motor adaptation beyond explicit knowledge

    Directory of Open Access Journals (Sweden)

    Herbert eHeuer

    2014-07-01

    Full Text Available Visuo-motor adaptation suffers at older working age. The age-related decline of behavioural adjustments is accompanied by reduced explicit knowledge of the visuo-motor transformation. It disappears when explicit knowledge is kept constant across the age range, except for particularly high levels of explicit knowledge. According to these findings, at older adult age both the acquisition of explicit knowledge and its application for strategic corrections become poorer. Recently it has been posited that visuo-motor adaptation can involve model-free reinforcement mechanisms of learning in addition to model-based mechanisms. We tested whether age-related declines of reinforcement learning can also contribute to the age-related changes of visuo-motor adaptation. Therefore we enhanced the contribution of reinforcement learning to visuo-motor adaptation by way of introducing salient markers of success and failure during practice. With such modified practice conditions, there were residual age-related variations of behavioural adjustments at all levels of explicit knowledge, even when explicit knowledge was absent. The residual age-related variations were observed for practiced target directions only, but not for new target directions. These findings are consistent with an age-related decline of model-free reinforcement learning as a third factor in the age-related decline of visuo-motor adaptation. Under practice conditions, which spur model-free reward-based learning, this factor adds to the decrements of the acquisition of explicit knowledge and its use for strategic corrections.

  4. Mapping fire effects on ash and soil properties. Current knowledge and future perspectives.

    Science.gov (United States)

    Pereira, Paulo; Cerda, Artemi; Strielko, Irina

    2014-05-01

    floor consumption (Lewis et al., 2011), ash cover (Robichaud et al., 2007) and other aspects related with soil as the vegetation factors that affect post-fire erosion risk (Fox et al., 2008). Field studies had also indented to estimate and map the impacts of fire in soil properties. Contrary to remote sensing studies, the mapping of fire effects on ash and soil properties in the field is specially carried out at small scale (e.g. slope or plot). The small scale resolution studies are important because identify small patterns that are normally ignored by remote sensing studies, but fundamental to understand the post-fire evolution of the burned areas. One of the important aspects of the small scale studies of fire effect on ash and soil properties is the great spatial variability, showing that the impact of fire is extremely heterogeneous in space and time (Outeiro et al., 2008; Pereira et al. in press). The small scale mapping of fire effects on soil properties normally is carried out using Geostatistical methods or using deterministic interpolation methods (Robichaud and Miller, 1999; Pereira et al., 2013). Several reports were published on the spatial distribution and mapping of ash and duff thickness (Robichaud and Miller, 1999; Pereira et al., 2013; Pereira et al. in press), fire severity (Pereira et al., 2014), ash chemical characteristics as total nitrogen (Pereira et al., 2010a), and ash extractable elements (Pereira et al., 2010b). Also, previous works mapped fire effects on soil temperature (Gimeno-Garcia et al., 2004), soil hydrophobicity (Woods et al., 2007), total nitrogen (Hirobe et al., 2003), phosphorous (Rodriguez et al., 2009) and major cations (Outeiro et al., 2008). It is important to integrate remote sensing and field based works of fire effects on ash and soil properties in order to have a better validation of the models predicted. The aim of this work is present the current knowledge about mapping fire effects in ash and soil properties at diverse

  5. Online strategies to facilitate health-related knowledge transfer: a systematic search and review.

    Science.gov (United States)

    Mairs, Katie; McNeil, Heather; McLeod, Jordache; Prorok, Jeanette C; Stolee, Paul

    2013-12-01

    Health interventions and practices often lag behind the available research, and the need for timely translation of new health knowledge into practice is becoming increasingly important. The objective of this study was to conduct a systematic search and review of the literature on online knowledge translation techniques that foster the interaction between various stakeholders and assist in the sharing of ideas and knowledge within the health field. The search strategy included all published literature in the English language since January 2003 and used the medline, Cumulative Index to Nursing and Allied Health Literature (cinahl), embase and Inspec databases. The results of the review indicate that online strategies are diverse, yet all are applicable in facilitating online health-related knowledge translation. The method of knowledge sharing ranged from use of wikis, discussion forums, blogs, and social media to data/knowledge management tools, virtual communities of practice and conferencing technology - all of which can encourage online health communication and knowledge translation. Online technologies are a key facilitator of health-related knowledge translation. This review of online strategies to facilitate health-related knowledge translation can inform the development and improvement of future strategies to expedite the translation of research to practice. © 2013 Health Libraries Group of CILIP and John Wiley & Sons Ltd.

  6. [Essential procedure and key methods for survey of traditional knowledge related to Chinese materia medica resources].

    Science.gov (United States)

    Cheng, Gong; Huang, Lu-qi; Xue, Da-yuan; Zhang, Xiao-bo

    2014-12-01

    The survey of traditional knowledge related to Chinese materia medica resources is the important component and one of the innovative aspects of the fourth national survey of the Chinese materia medica resources. China has rich traditional knowledge of traditional Chinese medicine (TCM) and the comprehensive investigation of TCM traditional knowledge aims to promote conservation and sustainable use of Chinese materia medica resources. Building upon the field work of pilot investigations, this paper introduces the essential procedures and key methods for conducting the survey of traditional knowledge related to Chinese materia medica resources. The essential procedures are as follows. First is the preparation phrase. It is important to review all relevant literature and provide training to the survey teams so that they have clear understanding of the concept of traditional knowledge and master key survey methods. Second is the field investigation phrase. When conducting field investigations, survey teams should identify the traditional knowledge holders by using the 'snowball method', record the traditional knowledge after obtaining prior informed concerned from the traditional knowledge holders. Researchers should fill out the survey forms provided by the Technical Specification of the Fourth National Survey of Chinese Materia Medica Resources. Researchers should pay particular attention to the scope of traditional knowledge and the method of inheriting the knowledge, which are the key information for traditional knowledge holders and potential users to reach mutual agreed terms to achieve benefit sharing. Third is the data compilation and analysis phrase. Researchers should try to compile and edit the TCM traditional knowledge in accordance with intellectual property rights requirements so that the information collected through the national survey can serve as the basic data for the TCM traditional knowledge database. The key methods of the survey include regional

  7. Causes of work-related stress and individual strategies in knowledge work

    DEFF Research Database (Denmark)

    Ipsen, Christine; Jensen, Per Langaa

    Recent studies point to work-related stress as an increasing problem for knowledge workers. This is a critical and not fully uncovered problem. The working life in knowledge-intensive companies is often described as good and stimulating. This study shows that some aspects of knowledge work can have...... a negative impact on daily activities and cause frustration and work-related stress. The study also finds that few primary preventive activities have been initiated. Based on an empirical study, the authors outline the characteristics of the job as knowledge worker and how it is being experienced. The study...... to the individual for his or her working life. Self-managed knowledge workers thus experience that they stand alone when it comes to work-related problems and stress. The stress intervention applied is characteristically short-term and focused on the individual. The individual perspective consequently affects...

  8. Investigating Relationships among Pre-Service Science Teachers' Conceptual Knowledge of Electric Current, Motivational Beliefs and Self-Regulation

    Science.gov (United States)

    Inaltun, Hüseyin; Ates, Salih

    2015-01-01

    The purpose of this study is to examine relationships among pre-service science teachers' conceptual knowledge of electric current, motivational beliefs, and self-regulation. One hundred and twenty-seven students (female = 107, male = 20) enrolled in the science education program of a public university in Ankara participated the study. A concept…

  9. [Current status of malaria control knowledge awareness of primary and sec- ondary school students in Xuzhou City].

    Science.gov (United States)

    Sun, Xing-sheng; Li, Li; Zhang, Kan-kan

    2015-12-01

    To understand the current status of malaria control knowledge awareness of primary and secondary school students and its influencing factors in Yunlong District, Xuzhou City, so as to provide the evidence for improving the malaria prevention work. A total of 800 students from 4 urban and rural primary and secondary schools were randomly selected and investigated with questionnaires. The total awareness rate of malaria control knowledge was 61.27%, and the awareness rates of symptoms of malaria and malaria prevention were only 38.99% and 57.59% respectively. The main approach of obtaining the malaria control knowledge was media (51.52%). The univariate analysis showed that sex, area and different education levels affected the awareness rates of malaria control knowledge (P knowledge of country students was lower than that of urban students (P knowledge of the secondary school students was higher than that of the primary school students (P knowledge of primary and secondary school students in Yunlong District is lower than that required by the national standard. Therefore, the health education of malaria control should be strengthened, especially in countryside school students and primary school students.

  10. Content knowledge development in a chemistry teacher preparation program: A current potentials and challenges

    Science.gov (United States)

    Widhiyanti, Tuszie; Treagust, David F.; Mocerino, Mauro; Vishnumolakala, Venkat

    2017-08-01

    One of the essential facets in teacher education program is the development of the teachers' content knowledge and it has been suggested by many scholars that the study to analyse the process of content knowledge development in teacher education program is necessary. Regarding this, the aim of this research is to evaluate the existing program of developing pre-service chemistry teachers' content knowledge, especially in the topic about the particulate nature of matter. The curriculum of content knowledge development was analysed using the forms of the curriculum evaluation (Akker, 1998; Goodlad, Klein, and Tye (1979); Treagust, 1987). Within this framework, the curriculum was evaluated in several aspects including the vision and intention of the curriculum as mentioned in the curriculum documents (intended curriculum), the users' interpretation and perception about the curriculum (perceived curriculum), the actual process of curriculum implementation (implemented curriculum), and the outcomes of the curriculum (achieved curriculum). According to the framework used for this study, the research combined qualitative and quantitative methods of data collection and the interpretation including document analysis, classroom observation, interviews, and two-tier diagnostic test. Through this research we examined the coherence among those aspects. The results reveal that although the content knowledge development is explicitly intended in a curriculum, its implementation and lecturers' perceptions give influence in the results as appear in pre-service teachers' achievements. In general, this research provides basic information about the effectiveness of the program including the challenges and the potentials for a reconsideration of the program in the future.

  11. Public Relations in Contemporary India: Current Demands and Strategy.

    Science.gov (United States)

    Singh, Raveena

    2000-01-01

    Discusses India's new direction and the persistent and insistent demand for public relations. Explains the strategic plan of the professional body in running the gauntlet in this new milieu and the pertinaciousness and urgency of the challenges ahead for public relations. (SC)

  12. HIV-Related Knowledge, Attitudes and Behaviours among College Students in China

    Science.gov (United States)

    Tung, Wei-Chen; Hu, Jie; Efird, Jimmy Thomas; Yu, Liping; Su, Wei

    2012-01-01

    Objectives: To assess the knowledge, attitudes, sources of HIV information and behaviours related to HIV, and to explore the difference in the HIV knowledge and attitudes between genders and school years among college students in China. Design: Descriptive, cross-sectional. Setting: 475 college students from two universities in China. Method: Data…

  13. Reviewing the relations between teachers' knowledge and pupils' attitude in the field of primary technology education

    NARCIS (Netherlands)

    Ruurd Taconis; dr. Ellen J. J Rohaan; Wim Jochems

    2010-01-01

    This literature review reports on the assumed relations between primary school teachers' knowledge of technology and pupils' attitude towards technology. In order to find relevant aspects of technology-specific teacher knowledge, scientific literature in the field of primary technology education was

  14. Process Mediates Structure: The Relation between Preschool Teacher Education and Preschool Teachers' Knowledge

    Science.gov (United States)

    Blömeke, Sigrid; Jenßen, Lars; Grassmann, Marianne; Dunekacke, Simone; Wedekind, Hartmut

    2017-01-01

    Data about processes and outcomes of preschool teacher education is scarce. This paper examines the opportunities to learn (OTL) of prospective preschool teachers (N = 1,851) at different types and stages of preschool teacher education and their relation to general pedagogical knowledge (GPK), mathematics pedagogical content knowledge (MPCK), and…

  15. The unique character of traditional forest-related knowledge: threats and challenges ahead

    Science.gov (United States)

    Ronald L. Trosper; John A. Parrotta; Mauro Agnoletti; Vladimir Bocharnikov; Suzanne A. Feary; Monica Gabay; Christian Gamborg; Jesus García Latorre; Elisabeth Johann; Andrey Laletin; Hin Fui Lim; Alfred Oteng-Yeboah; Miguel A. Pinedo-Vasquez; P.S. Ramakrishnan; Yeo-Chang. Youn

    2012-01-01

    This chapter refl ects on the major fi ndings of the lead authors of this book regarding traditional forest-related knowledge (TFRK) using five criteria for distinguishing the unique character of traditional knowledge: (1) its attention to sustainability; (2) relationships to land; (3) identity; (4) reciprocity; and (5) limitations on market involvement. Following an...

  16. Health-Related Fitness Knowledge Development through Project-Based Learning

    Science.gov (United States)

    Hastle, Peter A.; Chen, Senlin; Guarino, Anthony J.

    2017-01-01

    Purpose: The purpose of this study was to examine the process and outcome of an intervention using the project-based learning (PBL) model to increase students' health-related fitness (HRF) knowledge. Method: The participants were 185 fifth-grade students from three schools in Alabama (PBL group: n = 109; control group: n = 76). HRF knowledge was…

  17. Secondary Teachers’ Mathematics-related Beliefs and Knowledge about Mathematical Problem-solving

    Science.gov (United States)

    E Siswono, T. Y.; Kohar, A. W.; Hartono, S.

    2017-02-01

    This study investigates secondary teachers’ belief about the three mathematics-related beliefs, i.e. nature of mathematics, teaching mathematics, learning mathematics, and knowledge about mathematical problem solving. Data were gathered through a set of task-based semi-structured interviews of three selected teachers with different philosophical views of teaching mathematics, i.e. instrumental, platonist, and problem solving. Those teachers were selected from an interview using a belief-related task from purposively selected teachers in Surabaya and Sidoarjo. While the interviews about knowledge examine teachers’ problem solving content and pedagogical knowledge, the interviews about beliefs examine their views on several cases extracted from each of such mathematics-related beliefs. Analysis included the categorization and comparison on each of beliefs and knowledge as well as their interaction. Results indicate that all the teachers did not show a high consistency in responding views of their mathematics-related beliefs, while they showed weaknesses primarily on problem solving content knowledge. Findings also point out that teachers’ beliefs have a strong relationship with teachers’ knowledge about problem solving. In particular, the instrumental teacher’s beliefs were consistent with his insufficient knowledge about problem-solving, while both platonist and problem-solving teacher’s beliefs were consistent with their sufficient knowledge of either content or pedagogical problem solving.

  18. Aedes aegypti, Aedes albopictus, and dengue in Argentina: current knowledge and future directions

    Directory of Open Access Journals (Sweden)

    Darío Vezzani

    2008-02-01

    Full Text Available Since the reinfestation of South American countries by Ae. aegypti, dengue fever (DF and dengue hemorrhagic fever (DHF have become a major public health concern. The aim of this paper was to review the information related with Aedes vectors and dengue in Argentina since the reintroduction of Ae. aegypti in 1986. The geographic distribution of Ae. albopictus is restricted to the Northeast, and that of Ae. aegypti has expanded towards the South and the West in comparison with the records during the eradication campaign in the 1960s. Since 1998, 4,718 DF cases have been reported concentrated in the provinces of Salta, Formosa, Misiones, Jujuy and Corrientes. Despite the circulation of three dengue virus serotypes (DENV-1, -2 and -3 in the North of the country, DHF has not occurred until the present. The information published over the last two decades regarding mosquito abundance, temporal variations, habitat characteristics, competition, and chemical and biological control, was reviewed. Considering the available information, issues pending in Argentina are discussed. The presence of three DENV, the potential spread of Ae. albopictus, and the predicted climate change suggest that dengue situation will get worse in the region. Research efforts should be increased in the Northern provinces, where DHF is currently an actual risk.

  19. [Gene Therapy for Inherited RETINAL AND OPTIC NERVE Disorders: Current Knowledge].

    Science.gov (United States)

    Ďuďáková, Ľ; Kousal, B; Kolářová, H; Hlavatá, L; Lišková, P

    The aim of this review is to provide a comprehensive summary of current gene therapy clinical trials for monogenic and optic nerve disorders.The number of genes for which gene-based therapies are being developed is growing. At the time of writing this review gene-based clinical trials have been registered for Leber congenital amaurosis 2 (LCA2), retinitis pigmentosa 38, Usher syndrome 1B, Stargardt disease, choroideremia, achromatopsia, Leber hereditary optic neuropathy (LHON) and X-linked retinoschisis. Apart from RPE65 gene therapy for LCA2 and MT-ND4 for LHON which has reached phase III, all other trials are in investigation phase I and II, i.e. testing the efficacy and safety.Because of the relatively easy accessibility of the retina and its ease of visualization which allows monitoring of efficacy, gene-based therapies for inherited retinal disorders represent a very promising treatment option. With the development of novel therapeutic approaches, the importance of establishing not only clinical but also molecular genetic diagnosis is obvious.Key words: gene therapy, monogenic retinal diseases, optic nerve atrophy, mitochondrial disease.

  20. Modelling marine sediment biogeochemistry: Current knowledge gaps, challenges, and some methodological advice for advancement

    DEFF Research Database (Denmark)

    Lessin, Gennadi; Artioli, Yuri; Almroth-Rosell, Elin

    2018-01-01

    The benthic environment is a crucial component of marine systems in the provision of ecosystem services, sustaining biodiversity and in climate regulation, and therefore important to human society. With the contemporary increase in computational power, model resolution and technological improveme......The benthic environment is a crucial component of marine systems in the provision of ecosystem services, sustaining biodiversity and in climate regulation, and therefore important to human society. With the contemporary increase in computational power, model resolution and technological...... improvements in quality and quantity of benthic data, it is necessary to ensure that benthic systems are appropriately represented in coupled benthic-pelagic biogeochemical and ecological modelling studies. In this paper we focus on five topical challenges related to various aspects of modelling benthic...... environments: organic matter reactivity, dynamics of benthic-pelagic boundary layer, microphytobenthos, biological transport and small-scale heterogeneity, and impacts of episodic events. We discuss current gaps in their understanding and indicate plausible ways ahead. Further, we propose a three...

  1. Modelling Marine Sediment Biogeochemistry: Current Knowledge Gaps, Challenges, and Some Methodological Advice for Advancement

    Directory of Open Access Journals (Sweden)

    Gennadi Lessin

    2018-02-01

    Full Text Available The benthic environment is a crucial component of marine systems in the provision of ecosystem services, sustaining biodiversity and in climate regulation, and therefore important to human society. With the contemporary increase in computational power, model resolution and technological improvements in quality and quantity of benthic data, it is necessary to ensure that benthic systems are appropriately represented in coupled benthic-pelagic biogeochemical and ecological modelling studies. In this paper we focus on five topical challenges related to various aspects of modelling benthic environments: organic matter reactivity, dynamics of benthic-pelagic boundary layer, microphytobenthos, biological transport and small-scale heterogeneity, and impacts of episodic events. We discuss current gaps in their understanding and indicate plausible ways ahead. Further, we propose a three-pronged approach for the advancement of benthic and benthic-pelagic modelling, essential for improved understanding, management and prediction of the marine environment. This includes: (A development of a traceable and hierarchical framework for benthic-pelagic models, which will facilitate integration among models, reduce risk of bias, and clarify model limitations; (B extended cross-disciplinary approach to promote effective collaboration between modelling and empirical scientists of various backgrounds and better involvement of stakeholders and end-users; (C a common vocabulary for terminology used in benthic modelling, to promote model development and integration, and also to enhance mutual understanding.

  2. E-resource knowledge bases and link resolvers: an assessment of the current products and emerging trends

    Directory of Open Access Journals (Sweden)

    Marshall Breeding

    2012-07-01

    Full Text Available This article summarizes the findings of a study on e-resource knowledge bases and OpenURL-based link resolvers sponsored by the National Library of Sweden. The project involved soliciting detailed information from each of the providers of the major products in this genre, reviewing product information available on the web and in published articles, and conducting a survey addressed to libraries using these products. The report identified and presented comparative information on a top tier of products that includes KnowledgeWorks and 360 Link from Serials Solutions; SFX Global KnowledgeBase and the SFX link resolver from Ex Libris; LinkSource and the EBSCO Integrated Knowledge Base from EBSCO and the WorldCat knowledge base from OCLC. A second tier included TOUResolver from TDNet, Gold Rush from the Colorado Alliance of Research Libraries and GODOT from Simon Fraser University. Innovative Interfaces, Inc offers the WebBridge link resolver but does not produce a knowledge base. The library survey revealed relatively narrow differences in the statistical results. Serial Solutions emerged as more favorable in most categories except for end-user functionality where Ex Libris received higher ratings. The Global Open Knowledgebase project (GOKb is noteworthy as a nascent community-based effort to produce a knowledge base. Key trends noted include less emphasis on knowledge bases and link resolvers as stand-alone products as they become integral components of comprehensive discovery and automation products.

  3. [Current concepts in pathogenesis of age-related macular degeneration].

    Science.gov (United States)

    Kubicka-Trząska, Agnieszka; Karska-Basta, Izabella; Romanowska-Dixon, Bożena

    2014-01-01

    Age-related macular degeneration is the leading cause of central blindness in elderly population of the western world. The pathogenesis of this disease, likely multifactorial, is not well known, although a number of theories have been put forward, including oxidative stress, genetic interactions, hemodynamic imbalance, immune and inflammatory processes. The understanding of age-related macular degeneration pathogenesis will give rise to new approaches in prevention and treatment of the early and late stages of both atrophic and neovascular age-related macular degeneration.

  4. Malassezia: Estado del conocimiento y perspectivas en su estudio Malassezia: Current knowledge and study perspectives

    Directory of Open Access Journals (Sweden)

    Gustavo E. Giusiano

    2006-03-01

    knowledge of the ecology and epidemiology of this genus. Noteworthy antifungal susceptibility variations have been observed in some species, although there is not a standard method for these yeasts. There are few data about their biochemical characteristics, and the enzymes they produce might be important virulence factors, favouring host tissue invasion. Malassezia has been recognised as a member of the normal human and animal skin. Its implication in pathologic processes, including skin diseases to systemic infections, is the main issue in current investigations in order to determine the real pathogenic role of these yeasts.

  5. Current status of research and related activities in NAA application

    International Nuclear Information System (INIS)

    Ab Khalik bin Haji Wood

    1999-01-01

    Current activities of Analytical Chemistry Group of MINT (Malaysia Institute for Nuclear Technology Research) laboratory for elemental analysis of trace amounts in environmental samples such as air particulate matter (on air filter), soils/sediments, water, flora/fauna, oil sludge/waste sludge, and tailing/blasting slag and others, utilizing particularly NAA (Neutron Activation Analysis) method are reviewed. The laboratory participates in the IAEA-organized Interlaboratory Comparison Studies to ensure the analytical system. Other activities include analytical chemistry services with ICP-mass spectrometry and GC/GCMS to compliment the NAA and, moreover, air and marine pollution studies with participation in the UNDP/RCA/IAEA project. (S. Ohno)

  6. Current CTR-related tritium handling studies at ORNL

    International Nuclear Information System (INIS)

    Watson, J.S.; Bell, J.T.; Clinton, S.D.; Fisher, P.W.; Redman, J.D.; Smith, F.J.; Talbot, J.B.; Tung, C.P.

    1976-01-01

    The Oak Ridge National Laboratory has a comprehensive program concerned with plasma fuel recycle, tritium recovery from blankets, and tritium containment in fusion reactors. Two studies of most current interest are investigations of cryosorption pumping of hydrogen isotopes and measurements of tritium permeation rates through steam generator materials. Cryosorption pumping speeds have been measured for hydrogen, deuterium, and helium at pressures from 10 -8 torr to 3 x 10 -3 torr. Permeation rates through Incoloy 800 have been shown to be drastically reduced when the low pressure side of permeation tubes are exposed to steam. These results will be important considerations in the design of fusion reactor steam generators

  7. Child sun protection: sun-related attitudes mediate the association between children's knowledge and behaviours.

    Science.gov (United States)

    Wright, Caradee; Reeder, Anthony I; Gray, Andrew; Cox, Brian

    2008-12-01

    To describe and investigate the relationship among the sun-related knowledge, attitudes and behaviours of New Zealand primary schoolchildren and consider the roles of sex and school year level. A randomly selected, two-stage cluster sample of 488 children from 27 primary schools in five regions of New Zealand was surveyed regarding their sun-related knowledge, attitudes and behaviours. A scoring system was used to assign a knowledge, attitude and behaviour score to each child. Although knowledge increased with school year level, there was a decline in sun protective attitudes and behaviours. There was little variation in knowledge, attitudes and behaviour between boys and girls, but sex-year level interactions were found for knowledge and behaviour. When considering children's knowledge, attitudes and behaviours simultaneously, knowledge was only significantly associated with behaviours when mediated by attitudes. When targeting child sun protection and skin cancer prevention programmes, a focus on attitudes towards sun exposure and a suntan may prove beneficial in influencing sun-related behaviours.

  8. The Current Status and a New Approach for Chinese Doctors to Obtain Medical Knowledge Using Social Media: A Study of WeChat

    Directory of Open Access Journals (Sweden)

    Li Liu

    2018-01-01

    Full Text Available Background. WeChat is the most widely and frequently used mobile social media in China and has profoundly integrated into the daily life of many Chinese people. A variety of medicine-related information may be found on WeChat. As users of WeChat, doctors often access health-related information and even provide a variety of medical services or participate in various types of mobile communication with patients. Objective. This study is the first attempt to quantitatively explore the approaches by doctors of acquiring medical knowledge using Internet resources especially social media such as WeChat to access knowledge. Methods. A self-administered questionnaire was designed, distributed, collected, and analyzed utilizing the online survey tool Sojump. WeChat was adopted to randomly release the questionnaires using snowball sampling and collect the results after a certain amount of time. Results. 292 valid questionnaires out of 314 questionnaires by clinical doctors were analyzed. Regarding the current status of accessing medical knowledge among doctors, more than 60% of the doctors regularly used the Internet to search for medical knowledge, 19.86% used WeChat as a channel to acquire medical knowledge, and only 23.97% were satisfied with acquiring medical knowledge through the Internet. Regarding the frequency of WeChat usage, nearly 40% of the doctors accessed WeChat more than 20 times per day and over 70% used WeChat for over half an hour every day. Regarding the status of accessing medical knowledge through WeChat, nearly half (47.26% of the doctors stated that they often read professional medical articles on WeChat and the most common channel is friends’ moment sharing and public account subscriptions, with selection rates of 59.93% and 60.27%, respectively. The most desirable mode of acquiring medical knowledge through WeChat was the following: “professional medical knowledge from peers, with a reminder.” Conclusion. WeChat has become a

  9. An effective method of collecting practical knowledge by presentation of videos and related words

    Directory of Open Access Journals (Sweden)

    Satoshi Shimada

    2017-12-01

    Full Text Available The concentration of practical knowledge and experiential knowledge in the form of collective intelligence (the wisdom of the crowd is of interest in the area of skill transfer. Previous studies have confirmed that collective intelligence can be formed through the utilization of video annotation systems where knowledge that is recalled while watching videos of work tasks can be assigned in the form of a comment. The knowledge that can be collected is limited, however, to the content that can be depicted in videos, meaning that it is necessary to prepare many videos when collecting knowledge. This paper proposes a method for expanding the scope of recall from the same video through the automatic generation and simultaneous display of related words and video scenes. Further, the validity of the proposed method is empirically illustrated through the example of a field experiment related to mountaineering skills.

  10. A review on current knowledge and future prospects of organohalogen contaminants (OHCs) in Asian birds

    Energy Technology Data Exchange (ETDEWEB)

    Abbasi, Naeem Akhtar [Environmental Biology and Ecotoxicology Laboratory, Department of Environmental Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320 (Pakistan); Malik, Riffat Naseem, E-mail: r_n_malik2000@yahoo.co.uk [Environmental Biology and Ecotoxicology Laboratory, Department of Environmental Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320 (Pakistan); Frantz, Adrien [Sorbonne Universités, UPMC Univ Paris 06, UPEC, Paris 7, CNRS, INRA, IRD, Institut d' Ecologie et des Sciences de l' Environnement de Paris, F-75005, Paris (France); Jaspers, Veerle Leontina Bernard [Environmental Toxicology, Department of Biology, Norwegian University of Science and Technology (NTNU), Trondheim (Norway)

    2016-01-15

    The release of harmful chemicals in the Asian environment has recently increased dramatically due to rising industrial and agricultural activities. About 60% of the global human population is currently living on the Asian continent and may thus be exposed to a large range of different chemicals. Different classes of organohalogen chemicals have indeed been reported in various environmental compartments from Asia including humans and wildlife, but this issue has received less attention in birds. In this article, we reviewed the available literature on levels of legacy persistent organic pollutants (POPs) and various flame retardants (FRs) in Asian avifauna to analyze the existing pool of knowledge as well as to identify the gaps that should be addressed in future research. Furthermore, we discussed the variation in levels of organohalogens based on differences in regions, trophic level, dietary sources and migratory behaviors of species including distribution patterns in different tissues of birds. Although the mass of published literature is very low and even absent in many important regions of Asia, we deduced from the reported studies that levels of almost all classes of organohalogens (OHCs) including FRs were highest in East Asian countries such as Japan, China and South Korea, except for HCHs that were found at maximum levels in birds of South India. Concentrations (ng/g LW) of different OHCs in Asian birds ranged between < LOD (limit of detection) to 14,000,000 for polychlorinated biphenyls (PCBs), < LOD to 790,000 for dichlorodiphenyltrichloroethane (DDTs), < LOD to 12,000 for hexachlorobenzene (HCB), < LOD to 29,000 for hexachlorocyclohexanes (HCHs), < LOD to 47,000 for chlordanes (CHLs) and < LOD to 4600 for total cyclodienes. Further, ranges (ng/g LW) of 1.1 to 150,000 for Co-PCBs; < LOD to 27 for polychlorinated dibenzo-p-dioxins (PCDDs); < LOD to 45 for polychlorinated dibenzofurans (PCDFs) and 0.02 to 73 for PCDD/DFs have been reported in Asian aves

  11. A review on current knowledge and future prospects of organohalogen contaminants (OHCs) in Asian birds

    International Nuclear Information System (INIS)

    Abbasi, Naeem Akhtar; Malik, Riffat Naseem; Frantz, Adrien; Jaspers, Veerle Leontina Bernard

    2016-01-01

    The release of harmful chemicals in the Asian environment has recently increased dramatically due to rising industrial and agricultural activities. About 60% of the global human population is currently living on the Asian continent and may thus be exposed to a large range of different chemicals. Different classes of organohalogen chemicals have indeed been reported in various environmental compartments from Asia including humans and wildlife, but this issue has received less attention in birds. In this article, we reviewed the available literature on levels of legacy persistent organic pollutants (POPs) and various flame retardants (FRs) in Asian avifauna to analyze the existing pool of knowledge as well as to identify the gaps that should be addressed in future research. Furthermore, we discussed the variation in levels of organohalogens based on differences in regions, trophic level, dietary sources and migratory behaviors of species including distribution patterns in different tissues of birds. Although the mass of published literature is very low and even absent in many important regions of Asia, we deduced from the reported studies that levels of almost all classes of organohalogens (OHCs) including FRs were highest in East Asian countries such as Japan, China and South Korea, except for HCHs that were found at maximum levels in birds of South India. Concentrations (ng/g LW) of different OHCs in Asian birds ranged between < LOD (limit of detection) to 14,000,000 for polychlorinated biphenyls (PCBs), < LOD to 790,000 for dichlorodiphenyltrichloroethane (DDTs), < LOD to 12,000 for hexachlorobenzene (HCB), < LOD to 29,000 for hexachlorocyclohexanes (HCHs), < LOD to 47,000 for chlordanes (CHLs) and < LOD to 4600 for total cyclodienes. Further, ranges (ng/g LW) of 1.1 to 150,000 for Co-PCBs; < LOD to 27 for polychlorinated dibenzo-p-dioxins (PCDDs); < LOD to 45 for polychlorinated dibenzofurans (PCDFs) and 0.02 to 73 for PCDD/DFs have been reported in Asian aves

  12. Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances.

    Science.gov (United States)

    Haapakoski, Rita; Ebmeier, Klaus P; Alenius, Harri; Kivimäki, Mika

    2016-04-03

    The inflammation theory of depression, proposed over 20years ago, was influenced by early studies on T cell responses and since then has been a stimulus for numerous research projects aimed at understanding the relationship between immune function and depression. Observational studies have shown that indicators of immunity, especially C reactive protein and proinflammatory cytokines, such as interleukin 6, are associated with an increased risk of depressive disorders, although the evidence from randomized trials remains limited and only few studies have assessed the interplay between innate and adaptive immunity in depression. In this paper, we review current knowledge on the interactions between central and peripheral innate and adaptive immune molecules and the potential role of immune-related activation of microglia, inflammasomes and indoleamine-2,3-dioxygenase in the development of depressive symptoms. We highlight how combining basic immune methods with more advanced 'omics' technologies would help us to make progress in unravelling the complex associations between altered immune function and depressive disorders, in the identification of depression-specific biomarkers and in developing immunotherapeutic treatment strategies that take individual variability into account. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  13. Colloid-Facilitated Radionuclide Transport: Current State of Knowledge from a Nuclear Waste Repository Risk Assessment Perspective

    International Nuclear Information System (INIS)

    Reimus, Paul William; Zavarin, Mavrik; Wang, Yifeng

    2017-01-01

    This report provides an overview of the current state of knowledge of colloid-facilitated radionuclide transport from a nuclear waste repository risk assessment perspective. It draws on work that has been conducted over the past 3 decades, although there is considerable emphasis given to work that has been performed over the past 3-5 years as part of the DOE Used Fuel Disposition Campaign. The timing of this report coincides with the completion of a 3-year DOE membership in the Colloids Formation and Migration (CFM) partnership, an international collaboration of scientists studying colloid-facilitated transport of radionuclides at both the laboratory and field-scales in a fractured crystalline granodiorite at the Grimsel Test Site in Switzerland. This Underground Research Laboratory has hosted the most extensive and carefully-controlled set of colloid-facilitated solute transport experiments that have ever been conducted in an in-situ setting, and a summary of the results to date from these efforts, as they relate to transport over long time and distance scales, is provided in Chapter 3 of this report.

  14. Colloid-Facilitated Radionuclide Transport: Current State of Knowledge from a Nuclear Waste Repository Risk Assessment Perspective

    Energy Technology Data Exchange (ETDEWEB)

    Reimus, Paul William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Zavarin, Mavrik [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wang, Yifeng [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-01-25

    This report provides an overview of the current state of knowledge of colloid-facilitated radionuclide transport from a nuclear waste repository risk assessment perspective. It draws on work that has been conducted over the past 3 decades, although there is considerable emphasis given to work that has been performed over the past 3-5 years as part of the DOE Used Fuel Disposition Campaign. The timing of this report coincides with the completion of a 3-year DOE membership in the Colloids Formation and Migration (CFM) partnership, an international collaboration of scientists studying colloid-facilitated transport of radionuclides at both the laboratory and field-scales in a fractured crystalline granodiorite at the Grimsel Test Site in Switzerland. This Underground Research Laboratory has hosted the most extensive and carefully-controlled set of colloid-facilitated solute transport experiments that have ever been conducted in an in-situ setting, and a summary of the results to date from these efforts, as they relate to transport over long time and distance scales, is provided in Chapter 3 of this report.

  15. Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis.

    Science.gov (United States)

    Slevin, M; Badimon, L; Grau-Olivares, M; Ramis, M; Sendra, J; Morrison, M; Krupinski, J

    2010-03-01

    Activation of vasa vasorum (the microvessels supplying the major arteries) at specific sites in the adventitia initiates their proliferation or 'angiogenesis' concomitant with development of atherosclerotic plaques. Haemorrhagic, leaky blood vessels from unstable plaques proliferate abnormally, are of relatively large calibre but are immature neovessels poorly invested with smooth muscle cells and possess structural weaknesses which may contribute to instability of the plaque by facilitation of inflammatory cell infiltration and haemorrhagic complications. Weak neovascular beds in plaque intima as well as activated adventitial blood vessels are potential targets for molecular imaging and targeted drug therapy, however, the majority of tested, currently available imaging and therapeutic agents have been unsuccessful because of their limited capacity to reach and remain stably within the target tissue or cells in vivo. Nanoparticle technology together with magnetic resonance imaging has allowed the possibility of imaging of neovessels in coronary or carotid plaques, and infusion of nanoparticle suspensions using infusion catheters or implant-based drug delivery represents a novel and potentially much more efficient option for treatment. This review will describe the importance of angiogenesis in mediation of plaque growth and development of plaque instability and go on to investigate the possibility of future design of superparamagnetic/perfluorocarbon-derived nanoparticles for imaging of the vasculature in this disease or which could be directed to the adventitial vasa vasorum or indeed intimal microvessels and which can release active payloads directed against primary key external mitogens and intracellular signalling molecules in endothelial cells responsible for their activation with a view to inhibition of angiogenesis.

  16. Non-coding RNAs and plant male sterility: current knowledge and future prospects.

    Science.gov (United States)

    Mishra, Ankita; Bohra, Abhishek

    2018-02-01

    Latest outcomes assign functional role to non-coding (nc) RNA molecules in regulatory networks that confer male sterility to plants. Male sterility in plants offers great opportunity for improving crop performance through application of hybrid technology. In this respect, cytoplasmic male sterility (CMS) and sterility induced by photoperiod (PGMS)/temperature (TGMS) have greatly facilitated development of high-yielding hybrids in crops. Participation of non-coding (nc) RNA molecules in plant reproductive development is increasingly becoming evident. Recent breakthroughs in rice definitively associate ncRNAs with PGMS and TGMS. In case of CMS, the exact mechanism through which the mitochondrial ORFs exert influence on the development of male gametophyte remains obscure in several crops. High-throughput sequencing has enabled genome-wide discovery and validation of these regulatory molecules and their target genes, describing their potential roles performed in relation to CMS. Discovery of ncRNA localized in plant mtDNA with its possible implication in CMS induction is intriguing in this respect. Still, conclusive evidences linking ncRNA with CMS phenotypes are currently unavailable, demanding complementing genetic approaches like transgenics to substantiate the preliminary findings. Here, we review the recent literature on the contribution of ncRNAs in conferring male sterility to plants, with an emphasis on microRNAs. Also, we present a perspective on improved understanding about ncRNA-mediated regulatory pathways that control male sterility in plants. A refined understanding of plant male sterility would strengthen crop hybrid industry to deliver hybrids with improved performance.

  17. Echinococcus granulosus sensu lato genotypes infecting humans--review of current knowledge.

    Science.gov (United States)

    Alvarez Rojas, Cristian A; Romig, Thomas; Lightowlers, Marshall W

    2014-01-01

    Genetic variability in the species group Echinococcus granulosus sensu lato is well recognised as affecting intermediate host susceptibility and other biological features of the parasites. Molecular methods have allowed discrimination of different genotypes (G1-10 and the 'lion strain'), some of which are now considered separate species. An accumulation of genotypic analyses undertaken on parasite isolates from human cases of cystic echinococcosis provides the basis upon which an assessment is made here of the relative contribution of the different genotypes to human disease. The allocation of samples to G-numbers becomes increasingly difficult, because much more variability than previously recognised exists in the genotypic clusters G1-3 (=E. granulosus sensu stricto) and G6-10 (Echinococcus canadensis). To accommodate the heterogeneous criteria used for genotyping in the literature, we restrict ourselves to differentiate between E. granulosus sensu stricto (G1-3), Echinococcus equinus (G4), Echinococcus ortleppi (G5) and E. canadensis (G6-7, G8, G10). The genotype G1 is responsible for the great majority of human cystic echinococcosis worldwide (88.44%), has the most cosmopolitan distribution and is often associated with transmission via sheep as intermediate hosts. The closely related genotypes G6 and G7 cause a significant number of human infections (11.07%). The genotype G6 was found to be responsible for 7.34% of infections worldwide. This strain is known from Africa and Asia, where it is transmitted mainly by camels (and goats), and South America, where it appears to be mainly transmitted by goats. The G7 genotype has been responsible for 3.73% of human cases of cystic echinococcosis in eastern European countries, where the parasite is transmitted by pigs. Some of the samples (11) could not be identified with a single specific genotype belonging to E. canadensis (G6/10). Rare cases of human cystic echinococcosis have been identified as having been caused by

  18. Marine biodiversity in South Africa: an evaluation of current states of knowledge.

    Directory of Open Access Journals (Sweden)

    Charles L Griffiths

    Full Text Available Continental South Africa has a coastline of some 3,650 km and an Exclusive Economic Zone (EEZ of just over 1 million km(2. Waters in the EEZ extend to a depth of 5,700 m, with more than 65% deeper than 2,000 m. Despite its status as a developing nation, South Africa has a relatively strong history of marine taxonomic research and maintains comprehensive and well-curated museum collections totaling over 291,000 records. Over 3 million locality records from more than 23,000 species have been lodged in the regional AfrOBIS (African Ocean Biogeographic Information System data center (which stores data from a wider African region. A large number of regional guides to the marine fauna and flora are also available and are listed. The currently recorded marine biota of South Africa numbers at least 12,914 species, although many taxa, particularly those of small body size, remain poorly documented. The coastal zone is relatively well sampled with some 2,500 samples of benthic invertebrate communities have been taken by grab, dredge, or trawl. Almost none of these samples, however, were collected after 1980, and over 99% of existing samples are from depths shallower than 1,000 m--indeed 83% are from less than 100 m. The abyssal zone thus remains almost completely unexplored. South Africa has a fairly large industrial fishing industry, of which the largest fisheries are the pelagic (pilchard and anchovy and demersal (hake sectors, both focused on the west and south coasts. The east coast has fewer, smaller commercial fisheries, but a high coastal population density, resulting in intense exploitation of inshore resources by recreational and subsistence fishers, and this has resulted in the overexploitation of many coastal fish and invertebrate stocks. South Africa has a small aquaculture industry rearing mussels, oysters, prawns, and abalone-the latter two in land-based facilities. Compared with many other developing countries, South Africa has a well

  19. Current state of knowledge, beliefs, and attitudes toward organ transplantation among academic students in Poland and the potential means for altering them.

    Science.gov (United States)

    Nowak, E; Pfitzner, R; Koźlik, P; Kozynacka, A; Durajski, L; Przybyłowski, P

    2014-10-01

    Students manifest a high level of social commitment. Improving their knowledge and developing more positive attitudes toward organ transplantation may increase the number of organ donations. This study was an assessment of the knowledge and attitudes toward organ transplantation among young people in Poland, with an overview of current beliefs and potential methods for improving transplantology awareness. The study included 400 medical students and 400 nonmedical students from public universities in Kraków, Poland. Data were collected by using an anonymous questionnaire examining demographic factors and transplantology issues. Despite the overall positive attitude toward transplantology among academic students in Poland, the state of knowledge of the nonmedical population remains relatively low. The most important issues for social education to focus on are the role of presumed consent and brain death diagnosis, actual hazards of living donations, recipient qualification criteria, and the attitudes of religious authorities. The overall level of knowledge and the number of positive attitudes were significantly higher among medical students than among nonmedical students, proving that formal educational programs are more efficient than the more accessible but less reliable sources of knowledge. Introduction of transplantology issues in schools and churches, promoting the positive outcomes of organ transplantation rather than negating false beliefs, and eliminating misleading information from the media may significantly increase young people's knowledge and result in more positive attitudes toward transplantology in a society-wide fashion. This outcome could create a favorable background for introducing an opt-in system of consent for organ donation.

  20. Racial/ethnic differences in electronic cigarette knowledge, social norms, and risk perceptions among current and former smokers.

    Science.gov (United States)

    Webb Hooper, Monica; Kolar, Stephanie K

    2017-04-01

    Psychosocial factors that may affect electronic cigarette (e-cigarette) initiation or maintenance among racial/ethnic minorities are not well-understood. This study examined racial/ethnic differences in e-cigarette knowledge, risk perceptions, and social norms among current and former smokers. Individuals with a tobacco smoking history and an awareness of e-cigarettes (N=285) were recruited from the community from June to August 2014. Telephone-administered surveys assessed demographics, smoking status, and e-cigarette knowledge, risk perceptions, and normative beliefs. Analyses of covariance and multinomial logistic regression tested associations by race/ethnicity. Controlling for sociodemographics and smoking status, White participants scored significantly higher on e-cigarette knowledge, compared to both Hispanics and African Americans/Blacks. Knowledge was lower among African Americans/Blacks compared to Hispanics. Compared to both Whites and Hispanics, African American/Black participants held lower perceptions regarding e-cigarette health risks and were less likely to view e-cigarettes as addictive. Normative beliefs did not differ by race/ethnicity. In conclusion, e-cigarette knowledge, health risk perceptions, and perceived addictiveness differed by race/ethnicity. The variation in e-cigarette knowledge and beliefs among smokers and former smokers has implications for use, and potentially, dual use. Understanding these relationships in unrepresented populations can inform future research and practice. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Etiology and epidemiology of Pythium root rot in hydroponic crops: current knowledge and perspectives

    Directory of Open Access Journals (Sweden)

    John Clifford Sutton

    2006-09-01

    knowledge and understanding of the etiology and epidemiology of root rot, and its effects on the physiology of the whole plant, are discussed in relation to new research directions and development of better practices to manage the disease in hydroponic crops. Focus is on methods and technologies for tracking Pythium and root rot, and on developing, integrating, and optimizing treatments to suppress the pathogen in the root zone and progress of root rot.A etiologia e a epidemiologia da podridão radicular causada por Pythium spp. em cultivo hidropônico são revisadas com ênfase em conhecimentos e conceitos considerados importantes para o manejo de doenças em estufas comerciais. A podridão radicular causada por Pythium continuamente ameaça a produtividade de diversas culturas em sistemas hidropônicos, incluindo pepino, tomate, pimentão, espinafre, alface, capuchinha, rúcula, rosa, e crisântemo. Os principais agentes causais incluem Pythium aphanidermatum, Pythium dissotocum, espécies de Pythium do grupo F e Pythium ultimum var. ultimum. São apresentadas e discutidas as principais fontes do inóculo primário de Pythium spp. em sistemas hidropônicos, os processos de infecção e colonização de raízes pelos patógenos, o desenvolvimento de sintomas, a produção de inóculo em raízes, e a dispersão do inóculo na solução nutritiva. Descobertas recentes da existência de um elicitor produzido especificamente por P. aphanidermatum que pode provocar a necrose (descoloração das raízes infectadas e a transição da infecção da fase biotrofica para necrotrofica são consideradas. Efeitos de fatores ligados ao hospedeiro (susceptibilidade à doença, estádio fenológico, exsudatos radiculares, compostos fenólicos, ao ambiente radicular (meio de enraizamento, concentrações de oxigênio dissolvido e compostos fenólicos na solução nutritiva, comunidades microbianas e temperatura e as interferências humanas (práticas de cultivo e medidas de controle sobre

  2. Formalization and Interaction: Toward a Comprehensive History of Technology-Related Knowledge in Early Modern Europe.

    Science.gov (United States)

    Popplow, Marcus

    2015-12-01

    Recent critical approaches to what has conventionally been described as "scientific" and "technical" knowledge in early modern Europe have provided a wealth of new insights. So far, the various analytical concepts suggested by these studies have not yet been comprehensively discussed. The present essay argues that such comprehensive approaches might prove of special value for long-term and cross-cultural reflections on technology-related knowledge. As heuristic tools, the notions of "formalization" and "interaction" are proposed as part of alternative narratives to those highlighting the emergence of "science" as the most relevant development for technology-related knowledge in early modern Europe.

  3. Geothermal projects funded under the NER 300 programme - current state of development and knowledge gained

    Science.gov (United States)

    Shortall, Ruth; Uihlein, Andreas

    2017-04-01

    Introduction The NER 300 programme, managed by the European Commission is one of the largest funding programmes for innovative low-carbon energy demonstration projects. NER 300 is so called because it is funded from the sale of 300 million emission allowances from the new entrants' reserve (NER) set up for the third phase of the EU emissions trading system (ETS). The programme aims to successfully demonstrate environmentally safe carbon capture and storage (CCS) and innovative renewable energy (RES) technologies on a commercial scale with a view to scaling up production of low-carbon technologies in the EU. Consequently, it supports a wide range of CCS and RES technologies (bioenergy, concentrated solar power, photovoltaics, geothermal, wind, ocean, hydropower, and smart grids). Funded projects and the role of geothermal projects for the programme In total, about EUR 2.1 billion have been awarded through the programme's 2 calls for proposals (the first awarded in December 2012, the second in July 2014). The programme has awarded around EUR 70 million funding to 3 geothermal projects in Hungary, Croatia and France. The Croatian geothermal project will enter into operation during 2017 the Hungarian in 2018, and the French in 2020. Knowledge Sharing Knowledge sharing requirements are built into the legal basis of the programme as a critical tool to lower risks in bridging the transition to large-scale production of innovative renewable energy and CCS deployment. Projects have to submit annually to the European Commission relevant knowledge gained during that year in the implementation of their project. The relevant knowledge is aggregated and disseminated by the European Commission to industry, research, government, NGO and other interest groups and associations in order to provide a better understanding of the practical challenges that arise in the important step of scaling up technologies and operating them at commercial scale. The knowledge sharing of the NER 300

  4. Current knowledge attitudes, and practices of healthcare providers about leprosy in Assam, India

    Directory of Open Access Journals (Sweden)

    Sumit Kar

    2010-01-01

    Full Text Available Background: Leprosy is a chronic infectious disease that is associated with serious morbidity and is a disease of public health concern because of the case load and the social stigma attached to the disease. Aim: To understand the knowledge of, and attitudes towards, leprosy amongst healthcare providers in Assam, India. Settings and Design: This cross-sectional study was conducted during March to June 2007 in different health institutions of the Kamrup district of Assam. Results: Among the program managers interviewed, only half were organizing training sessions, and 37.5% were involved in supervision of the program activities at the periphery level. Among the program managers who were involved with leprosy elimination, only half were organizing training session and 37.5% were involved in supervision of the program activities at the periphery level. Medical officers consistently demonstrated higher knowledge about leprosy, followed by health supervisors and multipurpose workers (MPWs, including nursing staff. Regarding training status with regard to leprosy, 90% of medical officers, 80% of health supervisors and around 87% of MPWs (83% of male MPWs and 89% of female MPWs had attended training programs on leprosy. Regarding WHO MDT, 80% of health supervisors, 84.8% of male MPWs and 86.2% of female MPWs had an idea of MDT and treatment duration of various categories of patients. Conclusions: These observations suggest that there appear to be adequate knowledge and positive behavior among healthcare providers with regard to leprosy in this part of India. However, there is still a need to organize training programs at regular intervals to train new recruits, as well as reinforce and update the knowledge of those already trained.

  5. Mycobacterium bovis infection in the lion (Panthera leo): Current knowledge, conundrums and research challenges.

    Science.gov (United States)

    Viljoen, Ignatius M; van Helden, Paul D; Millar, Robert P

    2015-06-12

    Mycobacterium bovis has global public-health and socio-economic significance and can infect a wide range of species including the lion (Panthera leo) resulting in tuberculosis. Lions are classified as vulnerable under the IUCN Red List of Threatened Species and have experienced a 30% population decline in the past two decades. However, no attempt has been made to collate and critically evaluate the available knowledge of M. bovis infections in lions and potential effects on population. In this review we set out to redress this. Arguments suggesting that ingestion of infected prey animals are the main route of infection for lions have not been scientifically proven and research is needed into other possible sources and routes of infection. The paucity of knowledge on host susceptibility, transmission directions and therefore host status, manifestation of pathology, and epidemiology of the disease in lions also needs to be addressed. Advances have been made in diagnosing the presence of M. bovis in lions. However, these diagnostic tests are unable to differentiate between exposure, presence of infection, or stage of disease. Furthermore, there are contradictory reports on the effects of M. bovis on lion populations with more data needed on disease dynamics versus the lion population's reproductive dynamics. Knowledge on disease effects on the lion reproduction and how additional stressors such as drought or co-morbidities may interact with tuberculosis is also lacking. Filling these knowledge gaps will contribute to the understanding of mycobacterial infections and disease in captive and wild lions and assist in lion conservation endeavours. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Preface: conservation of european ponds-current knowledge and future needs

    OpenAIRE

    Miracle, Rosa; Oertli, Beat; Céréghino, Régis; Hull, Andrew P.

    2010-01-01

    Ponds are common elements of the landscape with an important role in the global processes of biosphere and biodiversity preservation. Recent research indicates that ecological characteristics of ponds are different from other inland water systems, but scientific knowledge is still insufficient and poor compared to lakes and rivers. Therefore, whilst indicators and conservation tools have been developed for most aquatic systems, there is also a gap between existing basic information on pond ec...

  7. Current knowledge of environmental exposure in children during the sensitive developmental periods

    Directory of Open Access Journals (Sweden)

    Norma Helena Perlroth

    2017-01-01

    Conclusion: To identify the causes and understand the mechanisms involved in the genesis of these diseases is a challenge for science, as there is still a lack of knowledge on children's susceptibility to many environmental contaminants. Prevention policies and more research on child environmental health, improving the recording and surveillance of environmental risks to children's health, should be an ongoing priority in the public health field.

  8. The Place of Culture in the Current International Relations

    Directory of Open Access Journals (Sweden)

    Constantin Frosin

    2011-05-01

    Full Text Available Culture and international relations easily appear to be mutually contradictory terms. To speak of "culture" is to invoke the creative capacities of human beings, to point, for example, to the constitutive role of values and visions, to the power of language and aesthetic expression, to communities great and small engaged in reconstructing normative aspirations and reshaping the possibilities for a decent way of life. To speak of "international relations," by contrast, is to draw upon an altogether bleaker account of the human condition, to refer to missiles and bombs, trade figures and debts, statesmanship and diplomacy, intrigue and force. It is to echo assertions about naked power and the sacrifice of cultural creativity and normative aspiration to the supposedly more enduring determinations of survival or supremacy. From the dark depths of international relations, the term culture takes on an aura of frivolity. It appears to refer to the idealistic and utopian, to the veneer of civilized decency that is always stripped away by the harsh realities of power politics and international conflict. This work aims at showing the contrary.

  9. Employee Relations And Organizational Knowledge Sharing: An Application In Banking Sector

    Directory of Open Access Journals (Sweden)

    Gülşah KARAVARDAR

    2012-06-01

    Full Text Available In this study, employee relations and knowledge sharing relation’s analysing is aimed. According to this aim, a private bank’s branches’, which are located in Istanbul/ Anatolia side, employees are applied surveys. For determining employee relations a survey which was developed by S.Liao and study friends is used. For determining the knowledge sharing, the survey which was developed by R. K. Yeo and M. A. Youssef is used. The independent variable is employee relations which consists of working environment, conditions of respect, conditions of support, justice perception, relationship with superiors, self-satisfaction and self-learning. The dependent variable is knowledge sharing. Regression Analysis is used. According to regression analysis results, conditions of respect, conditions of support, justice perception and relationships with superiors have an effect on knowledge sharing.

  10. Diabetes-Related Knowledge and Preventative Practices Among Government Employees with Diabetes in Kuwait

    Directory of Open Access Journals (Sweden)

    Ahmad J. Abdulsalam

    2018-01-01

    Full Text Available Objectives: Diabetes mellitus (DM-related knowledge and preventative practices are vital for the successful management of this condition. In Kuwait, few studies have been conducted to evaluate the knowledge and preventative practices of DM patients. This study aimed to assess DM-related knowledge and preventative practices among government employees with DM in Kuwait and to examine associations between DM knowledge, preventative practices and other variables. Methods: This cross-sectional study was conducted in June 2015 and involved 345 employees with DM from 15 government ministries in Kuwait. A self-administered Arabic-language questionnaire was designed to assess DM-related knowledge and preventative practices based on the Diabetes Knowledge Test and the recommendations of the American Diabetes Association, respectively. Results: A total of 312 ministry employees agreed to participate in the study (response rate: 90.4%. The mean age was 45.6 ± 10.6 years. A total of 63.4% were male and 64.1% were Kuwaiti. The median DM knowledge score was 9 out of 14 and the median preventative practice score was 5 out of 14. High knowledge scores were significantly associated with education (β = 1.510; P ≤0.001 and income (β = 0.896; P ≤0.001. High preventative practice scores were significantly associated with income (β = 1.376; P = 0.002, DM duration (β = 0.919; P = 0.026 and knowledge scores (β = 1.783; P = 0.015. Conclusion: Government employees in Kuwait were found to have average DM knowledge and poor preventative practices. It is therefore imperative that policy-makers develop educational and health-promoting campaigns to target government employees with DM in Kuwait.

  11. Diabetes-Related Knowledge and Preventative Practices Among Government Employees with Diabetes in Kuwait.

    Science.gov (United States)

    Abdulsalam, Ahmad J; Al-Daihani, Abdullah E; Francis, Kostantinos

    2017-11-01

    Diabetes mellitus (DM)-related knowledge and preventative practices are vital for the successful management of this condition. In Kuwait, few studies have been conducted to evaluate the knowledge and preventative practices of DM patients. This study aimed to assess DM-related knowledge and preventative practices among government employees with DM in Kuwait and to examine associations between DM knowledge, preventative practices and other variables. This cross-sectional study was conducted in June 2015 and involved 345 employees with DM from 15 government ministries in Kuwait. A self-administered Arabic-language questionnaire was designed to assess DM-related knowledge and preventative practices based on the Diabetes Knowledge Test and the recommendations of the American Diabetes Association, respectively. A total of 312 ministry employees agreed to participate in the study (response rate: 90.4%). The mean age was 45.6 ± 10.6 years. A total of 63.4% were male and 64.1% were Kuwaiti. The median DM knowledge score was 9 out of 14 and the median preventative practice score was 5 out of 14. High knowledge scores were significantly associated with education (β = 1.510; P ≤0.001) and income (β = 0.896; P ≤0.001). High preventative practice scores were significantly associated with income (β = 1.376; P = 0.002), DM duration (β = 0.919; P = 0.026) and knowledge scores (β = 1.783; P = 0.015). Government employees in Kuwait were found to have average DM knowledge and poor preventative practices. It is therefore imperative that policy-makers develop educational and health-promoting campaigns to target government employees with DM in Kuwait.

  12. What is the current state of scientific knowledge with regard to seasonal and decadal forecasting?

    International Nuclear Information System (INIS)

    Smith, Doug M; Scaife, Adam A; Kirtman, Ben P

    2012-01-01

    Environmental factors, such as the frequency, intensity and duration of extreme weather events, are important drivers of migration and displacement of people. There is therefore a growing need for regional climate predictions for the coming seasons to decades. This paper reviews the current state of the art of seasonal to decadal climate prediction, focusing on the potential sources of skill, forecasting techniques, current capability and future prospects. (letter)

  13. Population Survey of Knowledge about Oral Cancer and Related Factors in the Capital of Iran.

    Science.gov (United States)

    Azimi, Somayyeh; Ghorbani, Zahra; Tennant, Marc; Kruger, Estie; Safiaghdam, Hannaneh; Rafieian, Nasrin

    2017-08-24

    Knowledge about oral cancer risk factors and signs is thought to improve prevention and early diagnosis, and in turn, increases survival. In this population-based survey, knowledge about oral cancer was assessed in Iran. A total of 1800 self-administered questionnaires (collecting sociodemographic data and questions regarding oral cancer risk factors and signs) were distributed through random sampling. Final scores ranged between 0 and 15 for the risk factors and 0-11 for the signs. Scores below the median indicated a low level of knowledge, scores representing the third quartile of correct answers indicated a moderate level of knowledge, and scores representing the upper quartile indicated a high level of knowledge. Statistical tests were used for analysis of knowledge level in different sociodemographic categories. A total of 1312 participants completed the questionnaires. The average of knowledge scores for risk factors was 5.3 ± 3.0 and for signs was 4.5 ± 2.9. Overall, 75 and 56% respectively were able to identify major risk factors (smoking and alcohol); 23.5% could not define any related signs and symptoms. Dividing scores into quartiles indicated that three out of four people had "low" knowledge about risk factors and 58% had "low" knowledge about signs and symptoms. Females and highly educated people had more knowledge of oral cancer. Significant difference was found between job and level of knowledge (P = 0.001). This survey revealed that public knowledge of oral cancer was not satisfactory in Iran. Efforts should be done to inform and educate people with risk factors, initial clinical presentation, and symptoms, in order to improve prevention and promote early diagnosis.

  14. Current knowledge of burn injury first aid practices and applied traditional remedies: a nationwide survey.

    Science.gov (United States)

    Kattan, Abdullah E; AlShomer, Feras; Alhujayri, Abdulaziz K; Addar, Abdullah; Aljerian, Albaraa

    2016-01-01

    Burn first aid awareness has been shown to reduce morbidity and mortality. We present a report on the knowledge and practices of the Saudi population with regard to burn first aid and the application of traditional remedies. An internet-based survey was conducted to assess the public's knowledge on first aid practices and home remedies applied for burn injuries among Saudi adults. A total of 2758 individuals responded to the survey. There were 1178 (42.7 %) respondents who had previously received burn first aid information. One thousand five hundred fifty respondents had a history of burn exposure in which burn injury first aid was applied as follows: 1118 (72.1 %) removed clothing and accessories from the injured area; water was applied by 990 (63.9 %); among those who applied water, 877 (88.6 %) applied cold water; and only 57 (5.8 %) did so for more than 15 min. Wrapping the burn area was performed by 526 (33.9 %), and 985 (63.5 %) sought medical assistance. When it comes to traditional remedies, 2134 (77.4 %) knew of and/or implemented these remedies as first aid or to treat burns. Honey and toothpaste were the commonest among these remedies with 1491 (69.9 %) and 1147 (53.7 %), respectively. This was associated with female gender ( r  = 0.87, P  first aid. Proper burn first aid is a simple, cheap, and accessible means of managing burns initially. Although the majority of the respondents were university graduates (51.1 %), knowledge and implementation of burn first aid was very poor. Major healthcare agencies should review and promote a consistent guideline for burn first aid in an effort to tackle and minimize the effect of this grave injury.

  15. Knowledge-driven computational modeling in Alzheimer's disease research: Current state and future trends.

    Science.gov (United States)

    Geerts, Hugo; Hofmann-Apitius, Martin; Anastasio, Thomas J

    2017-11-01

    Neurodegenerative diseases such as Alzheimer's disease (AD) follow a slowly progressing dysfunctional trajectory, with a large presymptomatic component and many comorbidities. Using preclinical models and large-scale omics studies ranging from genetics to imaging, a large number of processes that might be involved in AD pathology at different stages and levels have been identified. The sheer number of putative hypotheses makes it almost impossible to estimate their contribution to the clinical outcome and to develop a comprehensive view on the pathological processes driving the clinical phenotype. Traditionally, bioinformatics approaches have provided correlations and associations between processes and phenotypes. Focusing on causality, a new breed of advanced and more quantitative modeling approaches that use formalized domain expertise offer new opportunities to integrate these different modalities and outline possible paths toward new therapeutic interventions. This article reviews three different computational approaches and their possible complementarities. Process algebras, implemented using declarative programming languages such as Maude, facilitate simulation and analysis of complicated biological processes on a comprehensive but coarse-grained level. A model-driven Integration of Data and Knowledge, based on the OpenBEL platform and using reverse causative reasoning and network jump analysis, can generate mechanistic knowledge and a new, mechanism-based taxonomy of disease. Finally, Quantitative Systems Pharmacology is based on formalized implementation of domain expertise in a more fine-grained, mechanism-driven, quantitative, and predictive humanized computer model. We propose a strategy to combine the strengths of these individual approaches for developing powerful modeling methodologies that can provide actionable knowledge for rational development of preventive and therapeutic interventions. Development of these computational approaches is likely to

  16. Current knowledge from experimental works with radioprotective drugs from the viewpoint of latest scientific research

    International Nuclear Information System (INIS)

    Skalka, J.

    2008-01-01

    The protection of both human and animal population against a radiation impairment proves to be an impulse for continuous intensive searching for plants with radioprotective properties, identification of their radioprotective components and examination of their effects both in vivo an in vitro. I am presenting the results as well as knowledge of a latest scientific research in this field with testing the following plants: Vigna radiata, Mentha piperita, Citrus aurantium var. amara, Syzygium cumini, Tinospora cordifolia, Aegle marmelos, Phyllanthus amarus, Aloe vera, Angelica sinensis, Rosemarinus officinalis, Panax ginseng, Hippophae rhamnoides, Ocimum sanctum, Crataegus microphylla. (authors)

  17. HISTORICAL CRITICAL PEDAGOGY AND OBJECTIVE KNOWLEDGE VERSUS THE MULTICULTURALISM AND RELATIVISM CURRENT ACADEMIC DEBATE

    Directory of Open Access Journals (Sweden)

    Julia Malanchen

    2015-06-01

    Full Text Available The article discusses the existing antagonistic understanding among the authors who discuss curriculum from the multiculturalist perspective and the authors of the Historical-Critical Pedagogy. The aim is to explain the postmodern relativists bases and multiculturalism, which opposes the defense of objective knowledge as central to the organization of a curriculum. Finally we point out what content should integrate an academic, with the objective, human development, human emancipation and social transformation, which allow the human being aim to provide social and consciously so increasingly free and universal.

  18. A Review on Current Status of Stability and Knowledge on Liquid Electrolyte-Based Dye-Sensitized Solar Cells

    Directory of Open Access Journals (Sweden)

    Frédéric Sauvage

    2014-01-01

    Full Text Available The purpose of this review is to gather the current background in materials development and provide the reader with an accurate image of today’s knowledge regarding the stability of dye-sensitized solar cells. This contribution highlights the literature from the 1970s to the present day on nanostructured TiO2, dye, Pt counter electrode, and liquid electrolyte for which this review is focused on.

  19. Knowledge, Attitudes and Behaviors Related to AIDS among Prisoners: Implications for Social Work Practice.

    Science.gov (United States)

    Miah, M. Mizanur Rahman; Olivero, J. Michael

    1995-01-01

    A survey of 33 male and 5 female prisoners examined their knowledge of AIDS and HIV transmission modes, current sexual behavior and safe sex practices, and sources of AIDS information and degree of trust in these sources. Discusses implications for social work practices and development of AIDS education for prisoners. (SV)

  20. Current Concept of IgG4-Related Disease.

    Science.gov (United States)

    Okazaki, Kazuichi; Umehara, Hisanori

    2017-01-01

    IgG4-related disease (IgG4-RD) is a fibroinflammatory disease of unknown etiology, which is characterized by a tendency to form tumefactive lesions, increased serum levels of IgG4, and massive infiltration of IgG4-positive plasma cells with storiform fibrosis and/or obliterative phlebitis. Patients with IgG4-RD have frequently multiorgan involvements such as the pancreas, biliary tree, salivary glands, periorbital tissues, kidneys, lungs, lymph nodes, and retroperitoneum. IgG4-RD mainly affects middle-aged to elderly men except for involvement in lachrymal and salivary glands, so-called Mikulicz's disease. The clinical manifestations of IgG4-RD depend on individually involved organs and respond well to steroid, but the prognosis still remains unclear. Some patients develop serious complications such as obstructive jaundice due to hepatic, gallbladder, or pancreatic lesions; hydronephrosis due to retroperitoneal fibrosis; or respiratory symptoms due to pulmonary lesions. Nomenclatures of individual organ manifestation of IgG4-RD have been internationally consented.

  1. The ecotoxicity of graphene family materials: current status, knowledge gaps and future needs

    International Nuclear Information System (INIS)

    Jastrzębska, Agnieszka Maria; Olszyna, Andrzej Roman

    2015-01-01

    Recently, graphene family materials (GFMs) have been introduced among all fields of science and still get numerous attention. Also, the applicability of these materials in many areas makes them very attractive. GFMs have attracted both academic and industrial interest as they can produce a dramatic improvement in materials properties at very low filler content. The aim of this review is to identify, summarize, and present the first available information on the influence of GFMs on soil and water environment as well as identify the knowledge gaps and indicate the directions for the next generation of the original scientific investigations. The paper also presents our first preliminary impact assessment and potential pathways of GFMs distribution in the environment. We used as an example the reduced graphene oxide/Al 2 O 3 nanocomposite (RGO/Al 2 O 3 ) that has been previously designed and synthesized by us. Authors believe that further work should focus on improvement of characterization methodology applicable for ecotoxicity analyses and possible interactions between GFMs and different living ecosystems. Consequently, the potential impact of graphene and its derivatives on environmental health is a matter of academic interest. However, potential hazards sufficient for risk assessment and concerned with GFMs usage in consumer products first need to be investigated and identified. Further research should focus on gathering knowledge on GFMs properties for life cycle analyses, which still poses a great challenge for scientists

  2. The ecotoxicity of graphene family materials: current status, knowledge gaps and future needs

    Energy Technology Data Exchange (ETDEWEB)

    Jastrzębska, Agnieszka Maria, E-mail: agsolgala@gmail.com; Olszyna, Andrzej Roman, E-mail: aolszyna@meil.pw.edu.pl [Warsaw University of Technology, Faculty of Materials Science and Engineering (Poland)

    2015-01-15

    Recently, graphene family materials (GFMs) have been introduced among all fields of science and still get numerous attention. Also, the applicability of these materials in many areas makes them very attractive. GFMs have attracted both academic and industrial interest as they can produce a dramatic improvement in materials properties at very low filler content. The aim of this review is to identify, summarize, and present the first available information on the influence of GFMs on soil and water environment as well as identify the knowledge gaps and indicate the directions for the next generation of the original scientific investigations. The paper also presents our first preliminary impact assessment and potential pathways of GFMs distribution in the environment. We used as an example the reduced graphene oxide/Al{sub 2}O{sub 3} nanocomposite (RGO/Al{sub 2}O{sub 3}) that has been previously designed and synthesized by us. Authors believe that further work should focus on improvement of characterization methodology applicable for ecotoxicity analyses and possible interactions between GFMs and different living ecosystems. Consequently, the potential impact of graphene and its derivatives on environmental health is a matter of academic interest. However, potential hazards sufficient for risk assessment and concerned with GFMs usage in consumer products first need to be investigated and identified. Further research should focus on gathering knowledge on GFMs properties for life cycle analyses, which still poses a great challenge for scientists.

  3. Knowledge, attitudes and practices relating to plastic containers for food and drinks.

    Science.gov (United States)

    Kasemsup, Rachada; Neesanan, Naiyana

    2011-08-01

    Plastic is widely used in daily life especially as food and drink containers. If these containers are used inappropriately, some chemicals such as bisphenol A, phthalate, and styrene from plastic may accumulate and impair organ function. To assess knowledge, attitudes, and practices relating to plastic containers for food and drinks among parents and health personnel. 100 parents and 100 health personnel from Queen Sirikit National Institute of Child Health are included in the present study. The questionnaires which contained 6 parts measuring knowledge, attitudes and practices about plastic containers for food and drinks are used to collect the data. There are no differences in knowledge, attitudes and practices relating to plastic containers between parents and health personnel. Even though, 80 percent of participants usually use plastic containers for food and drinks, their knowledge about plastic is inadequate. Parents and health personnel are aware of health effects of plastic containers, but they do not know how to use and purchase plastics properly.

  4. THE DESIGN OF KNOWLEDGE BASE FOR SURFACE RELATIONS BASED PART RECOGNITION APPROACH

    Directory of Open Access Journals (Sweden)

    Adem ÇİÇEK

    2007-01-01

    Full Text Available In this study, a new knowledge base for an expert system used in part recognition algorithm has been designed. Parts are recognized by the computer program by comparing face adjacency relations and attributes belonging to each part represented in the rules in the knowledge base developed with face adjacency relations and attributes generated from STEP file of the part. Besides, rule writing process has been quite simplified by generating the rules represented in the knowledge base with an automatic rule writing module developed within the system. With the knowledge base and automatic rule writing module used in the part recognition system, simple, intermediate and complex parts can be recognized by a part recognition program.

  5. The State of Knowledge of Outdoor Orientation Programs: Current Practices, Research, and Theory

    Science.gov (United States)

    Bell, Brent J.; Gass, Michael A.; Nafziger, Christopher S.; Starbuck, J. David

    2014-01-01

    Outdoor orientation programs represent a prominent area of experiential education with over 25,000 participants annually. More than 191 outdoor orientation programs currently operate in the United States and Canada. The research examining outdoor orientation programs consists of 25 peer-reviewed published studies and 11 dissertations. A new theory…

  6. Microbiology of Wind-eroded Sediments: Current Knowledge and Future Research Directions

    Science.gov (United States)

    Wind erosion is a threat to the sustainability and productivity of soils that takes place at local, regional, and global scales. Current estimates of cost of wind erosion have not included the costs associated with the loss of soil biodiversity and reduced ecosystem functions. Microorganisms carrie...

  7. Fire and invasive exotic plant species in eastern oak communities: an assessment of current knowledge

    Science.gov (United States)

    Cynthia D. Huebner

    2006-01-01

    Successful regeneration of oak-dominated communities in the Eastern United States historically requires disturbance such as fire, making them vulnerable to invasion by exotic plants. Little is currently known about the effects of fire on invasive plant species and the effects of invasive plant species on fire regimes of this region. Seventeen common eastern invaders...

  8. The linkage between car-related fringe benefits and the travel behavior of knowledge workers

    DEFF Research Database (Denmark)

    Bendit, Eduard; Frenkel, Amnon; Kaplan, Sigal

    2011-01-01

    This study focuses on the linkage between car-related fringe benefits and the travel behavior of knowledge workers in commute and leisure trips. Specifically, this study compares the commuting and leisure travel behavior of knowledge workers who receive either a company-car or car allowance...... with the travel behavior of workers who do not receive car-related fringe benefits. Data are based on a revealed-preferences survey among knowledge workers in Israel. Results show that car-related fringe benefits are associated with (i) high car ownership and car use intensity, (ii) long commute distances...... and travel times and non-sustainable transport modes, and (iii) high frequency of long-distance leisure trips. Policy implications include (i) directing policies towards reducing car ownership induced by car-related fringe benefits, (ii) encouraging company-car holders to ‘pay their way’, and (iii...

  9. Exploring AIDS-related knowledge, attitudes, and behaviors of female Mexican migrant workers.

    Science.gov (United States)

    Organista, P B; Organista, K C; Soloff, P R

    1998-05-01

    AIDS-related knowledge, attitudes, and behaviors were assessed in female Mexican migrant laborers. Thirty-two women were administered a modified version of the Hispanic Condom Questionnaire. Respondents were knowledgeable about the major modes of HIV transmission, but one-third to one-half of the women believed that they could contract AIDS from unlikely casual sources. Although respondents reported few negative beliefs about condom use, actual condom use with sex partners was low and knowledge of proper condom use was problematic. Consequently, 75 percent reported never carrying condoms. Implications of these findings for future research and provision of services for female Mexican migrants are discussed.

  10. Oral health related knowledge and health behavior of parents and school children

    OpenAIRE

    Lalić Maja; Aleksić Ema; Gajić Mihajlo; Malešević Đoka

    2013-01-01

    Introduction. The family provides the background for developing behaviors, attitudes and knowledge related to oral health of children. The aim of this study was to compare oral health behavior of parents and their children and to asses the impact of parental behavior on children’s oral health. Material and Methods. This cross-sectional study included 99 parent - child pairs (12 to 15 years old). Data on oral health behavior, knowledge and attitudes regarding oral hygiene, fluorides and ...

  11. Relation of Occupational Knowledge to Career Interests and Competence Perceptions in Italian Children

    Science.gov (United States)

    Rohlfing, Jessica E.; Nota, Laura; Ferrari, Lea; Soresi, Salvatore; Tracey, Terence J. G.

    2012-01-01

    The relations of differential occupational knowledge with interests and competence perceptions in children as well as how these relations were moderated by gender and grade were examined in this study using an Italian sample. Data were collected from samples of elementary school and middle school children (N = 539). The Inventory of Children's…

  12. Sport Physiology Research and Governing Gender in Sport--A Power-Knowledge Relation?

    Science.gov (United States)

    Larsson, Hakan

    2013-01-01

    This article sets out to show how physiological knowledge about sex/gender relates to power issues within sport. The sport physiology research at the Swedish School of Sport and Health Sciences (Swedish acronym: GIH) during the twentieth century is analysed in relation to the political rationality concerning gender at GIH and within the Swedish…

  13. Elementary Physical Education Teachers' Content Knowledge of Physical Activity and Health-Related Fitness

    Science.gov (United States)

    Santiago, Jose A.; Disch, James G.; Morales, Julio

    2012-01-01

    The purpose of this study was to examine elementary physical education teachers' content knowledge of physical activity and health-related fitness. Sixty-four female and 24 male teachers completed the Appropriate Physical Activity and Health-Related Fitness test. Descriptive statistics results indicated that the mean percentage score for the test…

  14. Belief, Knowledge and Understanding: How to Deal with the Relations between Different Cultural Perspectives in Classrooms

    Science.gov (United States)

    Moreira-dos-Santos, Frederik; El-Hani, Charbel N.

    2017-01-01

    This article discusses how to deal with the relations between different cultural perspectives in classrooms, based on a proposal for considering understanding and knowledge as goals of science education, inspired by Dewey's naturalistic humanism. It thus combines educational and philosophical interests. In educational terms, our concerns relate to…

  15. The invasive mosquito species Aedes albopictus: current knowledge and future perspectives

    Science.gov (United States)

    Bonizzoni, Mariangela; Gasperi, Giuliano; Chen, Xioaguang; James, Anthony A.

    2013-01-01

    One of the most dynamic events in public health is being mediated by the global spread of the invasive mosquito Aedes albopictus. Its rapid expansion and vectorial capacity for various arboviruses affect an increasingly larger proportion of the world population. Responses to the challenges of controlling this vector are expected to be enhanced by an increased knowledge of its biology, ecology, and vector competence. Details of population genetics and structure will allow following, and possibly predicting, the geographical and temporal dynamics of its expansion, and will inform the practical operations of control programs. Experts are coming together now to describe the history, characterize the present circumstances, and collaborate on future efforts to understand and mitigate this emerging public health threat. PMID:23916878

  16. Current and future health care professionals attitudes toward and knowledge of statistics: How confidence influences learning.

    Science.gov (United States)

    Baghi, Heibatollah; Kornides, Melanie L

    2013-01-01

    Health care professionals require some understanding of statistics to successfully implement evidence based practice. Developing competency in statistical reasoning is necessary for students training in health care administration, research, and clinical care. Recently, the interest in healthcare professional's attitudes toward statistics has increased substantially due to evidence that these attitudes can hinder professionalism developing an understanding of statistical concepts. In this study, we analyzed pre- and post-instruction attitudes towards and knowledge of statistics obtained from health science graduate students, including nurses and nurse practitioners, enrolled in an introductory graduate course in statistics (n = 165). Results show that the students already held generally positive attitudes toward statistics at the beginning of course. However, these attitudes-along with the students' statistical proficiency-improved after 10 weeks of instruction. The results have implications for curriculum design and delivery methods as well as for health professionals' effective use of statistics in critically evaluating and utilizing research in their practices.

  17. Chilean jagged lobster, Projasus bahamondei, in the southeastern Pacific Ocean: current state of knowledge

    Directory of Open Access Journals (Sweden)

    Patricio M Arana

    2014-03-01

    Full Text Available The Chilean jagged lobster (Projasus bahamondei is a deep-water crustacean (175-550 m occurring in certain areas of the southeastern Pacific Ocean, including the Nazca Ridge, Desventuradas Islands, the Juan Fernandez archipelago and ridge, and the continental slope off the central coast of Chile. This review describes the taxonomic status, geographical and bathymetric distribution, some biological aspects and habitat characteristics of this species. Additionally, both artisanal and industrial exploitation attempts made within the region are detailed, as well as fishing operation results, chemical composition, different elaboration procedures and the destination of the catch. The main objectives of this review are to contribute to the knowledge of P. bahamondei as a component of the deep-sea ecosystem and to highlight its importance as a potential fishery resource.

  18. Hydrogeology and management of freshwater lenses on atoll islands: Review of current knowledge and research needs

    Science.gov (United States)

    Werner, Adrian D.; Sharp, Hannah K.; Galvis, Sandra C.; Post, Vincent E. A.; Sinclair, Peter

    2017-08-01

    On atoll islands, fresh groundwater occurs as a buoyant lens-shaped body surrounded by saltwater derived from the sea, forming the main freshwater source for many island communities. A review of the state of knowledge of atoll island groundwater is overdue given their susceptibility to adverse impacts, and the task to address water access and sanitation issues within the United Nations' Sustainable Development Goals framework before the year 2030. In this article, we review available literature to summarise the key processes, investigation techniques and management approaches of atoll island groundwater systems. Over fifty years of investigation has led to important advancements in the understanding of atoll hydrogeology, but a paucity of hydrogeological data persists on all but a small number of atoll islands. We find that the combined effects of buoyancy forces, complex geology, tides, episodic ocean events, strong climatic variability and human impacts create highly dynamic fresh groundwater lenses. Methods used to quantify freshwater availability range from simple empirical relationships to three-dimensional density-dependent models. Generic atoll island numerical models have proven popular in trying to unravel the individual factors controlling fresh groundwater lens behaviour. Major challenges face the inhabitants and custodians of atoll island aquifers, with rising anthropogenic stresses compounded by the threats of climate variability and change, sea-level rise, and some atolls already extracting freshwater at or above sustainability limits. We find that the study of atoll groundwater systems remains a critical area for further research effort to address persistent knowledge gaps, which lead to high uncertainties in water security issues for both island residents and surrounding environs.

  19. [Leptospirosis in French Guiana and the Guiana shield: Current knowledge in 2016].

    Science.gov (United States)

    Epelboin, L; Bourhy, P; Le Turnier, P; Schaub, R; Mosnier, E; Berlioz-Arthaud, A; Reynaud, Y; Nacher, M; De Thoisy, B; Carles, G; Richard-Hansen, C; Demar, M; Picardeau, M; Djossou, F

    2017-08-01

    Leptospirosis is a cosmopolitan zoonosis caused by bacteria of the genus Leptospira. Whether the distribution is worldwide, the hot and humid climate of the tropics is particularly conducive to its expansion. In most French overseas departments and territories, leptospirosis is considered as a public health problem. In French Guiana, a French department located in the northeastern part of the Amazon rainforest, it is supposed to be rare. The objective of this review was to make an inventory of the knowledge on human and animal leptospirosis in French Guiana and neighboring countries. A comprehensive search was conducted through the indexed and informal medical literature in English, French, Spanish and Portuguese. Thus, respectively ten and four publications were identified on human and animal leptospirosis in French Guiana, published between 1940 and 1995 in the form of case reports or case series. The publications concerning this disease in the other countries of the Guiana Shield, eastern Venezuela, Guyana, Suriname, and Brazilian state of Amapá, also scarce or nonexistent. However recent data from the French National Centre of leptospirosis showed a recent and sudden increase in the number of cases in the department, probably partly due to the development of diagnostic tools such as Elisa IgM serology. It is likely that leptospirosis is a neglected disease in the region, due to the lack of diagnostic tools readily available, the lack of knowledge of the local clinicians on this disease and the existence of many other pathogens with similar clinical presentation such as malaria, arboviruses and Q fever and Amazonian toxoplasmosis. The establishment of more large-scale studies on animal and human leptospirosis is necessary and urgent to know the true burden of this disease in our region.

  20. Strategies to translate knowledge related to common musculoskeletal conditions into physiotherapy practice: a systematic review.

    Science.gov (United States)

    Bérubé, Marie-Ève; Poitras, Stéphane; Bastien, Marc; Laliberté, Lydie-Anne; Lacharité, Anyck; Gross, Douglas P

    2018-03-01

    Many physiotherapists underuse evidence-based practice guidelines or recommendations when treating patients with musculoskeletal disorders, yet synthesis of knowledge translation interventions used within the field of physiotherapy fails to offer clear conclusions to guide the implementation of clinical practice guidelines. To evaluate the effectiveness of various knowledge translation interventions used to implement changes in the practice of current physiotherapists treating common musculoskeletal issues. A computerized literature search of MEDLINE, CINHAL and ProQuest of systematic reviews (from inception until May 2016) and primary research studies (from January 2010 until June 2016). Eligibility criteria specified articles evaluating interventions for translating knowledge into physiotherapy practice. Two reviewers independently screened the titles and abstracts, reviewed full-text articles, performed data extraction, and performed quality assessment. Of a total of 13014 articles located and titles and abstracts screened, 34 studies met the inclusion criteria, including three overlapping publications, resulting in 31 individual studies. Knowledge translation interventions appear to have resulted in a positive change in physiotherapist beliefs, attitudes, skills and guideline awareness. However, no consistent improvement in clinical practice, patient and economic outcomes were observed. The studies included had small sample sizes and low methodological quality. The heterogeneity of the studies was not conducive to pooling the data. The intensity and type of knowledge translation intervention seem to have an effect on practice change. More research targeting financial, organizational and regulatory knowledge translation interventions is needed. Copyright © 2017 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

  1. Diabetes related knowledge among residents and nurses: a multicenter study in Karachi, Pakistan

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    Ahmed Asma

    2012-09-01

    Full Text Available Abstract Background Assessment of knowledge among resident trainees and nurses is very important since majority of patients admitted in hospital have underlying diabetes which could lead to adverse clinical outcomes if not managed efficiently. Therefore, the purpose of this study was to evaluate and compare the knowledge related to the management of diabetes among registered nurses (RN and trainee residents of internal medicine (IMR, family medicine (FMR and surgery (SR at tertiary care hospitals of Karachi, Pakistan. Methods A validated questionnaire consisting of 21 open ended questions related to diabetes awareness was acquired through a study done at Thomas Jefferson University Hospital, Philadelphia with the permission of primary author. Results 169 IMR, 27 FMR, 86 SR and 99 RN completed a questionnaire that assessed the knowledge related to different aspects of management of diabetes. The results were further stratified by participant's specialty and level of training. The percentage of knowledge based questions answered correctly was found to be low. The overall mean correct percentage among all the participants was 50% +/- 21. There was no statistical difference in terms of knowledge between IMR & FMR residents (64% +/- 14 vs. 60% +/- 16, p = 0.47 respectively. The total scores of SR and RN were quite low (40% +/- 16 & 31% +/- 15 respectively.SR and RN were found to have profound deficit in both inpatient and outpatient knowledge of diabetes. We did not observe any improvement in level of knowledge of FMR & SR with increase in duration of their training (p = 0.47 & 0.80 respectively. In contrast, improvement in the level of knowledge of IMR was observed from first to second year of their training (p = 0.03 with no further improvement thereafter. RN's didn't respond correctly on most of the items related to in-patient management of diabetes (Mean score 40% +/- 20. Conclusion As there are no prior studies in our setting

  2. Diabetes related knowledge among residents and nurses: a multicenter study in Karachi, Pakistan.

    Science.gov (United States)

    Ahmed, Asma; Jabbar, Abdul; Zuberi, Lubna; Islam, Muhammad; Shamim, Khusro

    2012-09-11

    Assessment of knowledge among resident trainees and nurses is very important since majority of patients admitted in hospital have underlying diabetes which could lead to adverse clinical outcomes if not managed efficiently. Therefore, the purpose of this study was to evaluate and compare the knowledge related to the management of diabetes among registered nurses (RN) and trainee residents of internal medicine (IMR), family medicine (FMR) and surgery (SR) at tertiary care hospitals of Karachi, Pakistan. A validated questionnaire consisting of 21 open ended questions related to diabetes awareness was acquired through a study done at Thomas Jefferson University Hospital, Philadelphia with the permission of primary author. 169 IMR, 27 FMR, 86 SR and 99 RN completed a questionnaire that assessed the knowledge related to different aspects of management of diabetes. The results were further stratified by participant's specialty and level of training. The percentage of knowledge based questions answered correctly was found to be low. The overall mean correct percentage among all the participants was 50% +/- 21. There was no statistical difference in terms of knowledge between IMR & FMR residents (64% +/- 14 vs. 60% +/- 16, p = 0.47) respectively. The total scores of SR and RN were quite low (40% +/- 16 & 31% +/- 15 respectively).SR and RN were found to have profound deficit in both inpatient and outpatient knowledge of diabetes. We did not observe any improvement in level of knowledge of FMR & SR with increase in duration of their training (p = 0.47 & 0.80 respectively). In contrast, improvement in the level of knowledge of IMR was observed from first to second year of their training (p = 0.03) with no further improvement thereafter. RN's didn't respond correctly on most of the items related to in-patient management of diabetes (Mean score 40% +/- 20). As there are no prior studies in our setting evaluating knowledge related to diabetes management among

  3. Current Technologies Based on the Knowledge of the Stem Cells Microenvironments.

    Science.gov (United States)

    Mawad, Damia; Figtree, Gemma; Gentile, Carmine

    2017-01-01

    The stem cell microenvironment or niche plays a critical role in the regulation of survival, differentiation and behavior of stem cells and their progenies. Recapitulating each aspect of the stem cell niche is therefore essential for their optimal use in in vitro studies and in vivo as future therapeutics in humans. Engineering of optimal conditions for three-dimensional stem cell culture includes multiple transient and dynamic physiological stimuli, such as blood flow and tissue stiffness. Bioprinting and microfluidics technologies, including organs-on-a-chip, are among the most recent approaches utilized to replicate the three-dimensional stem cell niche for human tissue fabrication that allow the integration of multiple levels of tissue complexity, including blood flow. This chapter focuses on the physico-chemical and genetic cues utilized to engineer the stem cell niche and provides an overview on how both bioprinting and microfluidics technologies are improving our knowledge in this field for both disease modeling and tissue regeneration, including drug discovery and toxicity high-throughput assays and stem cell-based therapies in humans.

  4. A Survey of Current Knowledge on Sexually Transmitted Diseases and Sexual Behaviour in Italian Adolescents.

    Science.gov (United States)

    Drago, Francesco; Ciccarese, Giulia; Zangrillo, Francesca; Gasparini, Giulia; Cogorno, Ludovica; Riva, Silvia; Javor, Sanja; Cozzani, Emanuele; Broccolo, Francesco; Esposito, Susanna; Parodi, Aurora

    2016-04-13

    Worldwide, 500 million people a year acquire a sexually transmitted disease (STD). Adolescents, accounting for 25% of the sexually active population, are the most affected. To analyze sexual behavior among Italian adolescents and their knowledge of STDs, with the goal of preventing their transmission, a questionnaire was administered to 2867 secondary school students (1271 males and 1596 females) aged 14-21 years. For the study, 1492 students were interviewed in Genoa (Northern Italy) and 1375 in Lecce (Southern Italy). For 37% of the respondents, parents and teachers were the main source of information on sex, and 95% believed that school should play the primary role in sex education. However, only 9% considered the sex education they received in school good. Noteworthy, only 0.5% of the teenagers recognized the sexually transmitted diseases from a list of diseases, and 54% of them did not know what a Pap test was. Confusion about the meaning of contraception and prevention was evident; only 22% knew that condoms and abstinence are the only methods for preventing STDs. Finally, a consistent number of students are exposed to risk factors for STDs transmission; e.g., alcohol and recreational drug use, promiscuity and improper condom use. On the basis of our study, there is an urgent need for the introduction of sex education as a proper subject in Italian schools.

  5. A Survey of Current Knowledge on Sexually Transmitted Diseases and Sexual Behaviour in Italian Adolescents

    Directory of Open Access Journals (Sweden)

    Francesco Drago

    2016-04-01

    Full Text Available Worldwide, 500 million people a year acquire a sexually transmitted disease (STD. Adolescents, accounting for 25% of the sexually active population, are the most affected. To analyze sexual behavior among Italian adolescents and their knowledge of STDs, with the goal of preventing their transmission, a questionnaire was administered to 2867 secondary school students (1271 males and 1596 females aged 14–21 years. For the study, 1492 students were interviewed in Genoa (Northern Italy and 1375 in Lecce (Southern Italy. For 37% of the respondents, parents and teachers were the main source of information on sex, and 95% believed that school should play the primary role in sex education. However, only 9% considered the sex education they received in school good. Noteworthy, only 0.5% of the teenagers recognized the sexually transmitted diseases from a list of diseases, and 54% of them did not know what a Pap test was. Confusion about the meaning of contraception and prevention was evident; only 22% knew that condoms and abstinence are the only methods for preventing STDs. Finally, a consistent number of students are exposed to risk factors for STDs transmission; e.g., alcohol and recreational drug use, promiscuity and improper condom use. On the basis of our study, there is an urgent need for the introduction of sex education as a proper subject in Italian schools.

  6. Regulation of phosphorus uptake and utilization: transitioning from current knowledge to practical strategies.

    Science.gov (United States)

    Hasan, Md Mahmudul; Hasan, Md Mainul; Teixeira da Silva, Jaime A; Li, Xuexian

    2016-01-01

    Phosphorus is a poorly bioavailable macronutrient that is essential for crop growth and yield. Overuse of phosphorus fertilizers results in low phosphorus use efficiency (PUE), has serious environmental consequences and accelerates the depletion of phosphorus mineral reserves. It has become extremely challenging to improve PUE while preserving global food supplies and maintaining environmental sustainability. Molecular and genetic analyses have revealed the primary mechanisms of phosphorus uptake and utilization and their relationships to phosphorus transporters, regulators, root architecture, metabolic adaptations, quantitative trait loci, hormonal signaling and microRNA. The ability to improve PUE requires a transition from this knowledge of molecular mechanisms and plant architecture to practical strategies. These could include: i) the use of arbuscular mycorrhizal fungal symbioses for efficient phosphorus mining and uptake; ii) intercropping with suitable crop species to achieve phosphorus activation and mobilization in the soil; and iii) tissue-specific overexpression of homologous genes with advantageous agronomic properties for higher PUE along with breeding for phosphorus-efficient varieties and introgression of key quantitative trait loci. More effort is required to further dissect the mechanisms controlling phosphorus uptake and utilization within plants and provide new insight into the means to efficiently improve PUE.

  7. Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis

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    Sarah Rebecca Porter

    2011-01-01

    Full Text Available Q fever is an ubiquitous zoonosis caused by an resistant intracellular bacterium, Coxiella burnetii. In certain areas, Q fever can be a severe public health problem, and awareness of the disease must be promoted worldwide. Nevertheless, knowledge of Coxiella burnetii remains limited to this day. Its resistant (intracellular and environmental and infectious properties have been poorly investigated. Further understanding of the interactions between the infected host and the bacteria is necessary. Domestic ruminants are considered as the main reservoir of bacteria. Infected animals shed highly infectious organisms in milk, feces, urine, vaginal mucus, and, very importantly, birth products. Inhalation is the main route of infection. Frequently asymptomatic in humans and animals, Q fever can cause acute or chronic infections. Financial consequences of infection can be dramatic at herd level. Vaccination with inactive whole-cell bacteria has been performed and proved effective in humans and animals. However, inactive whole-cell vaccines present several defects. Recombinant vaccines have been developed in experimental conditions and have great potential for the future. Q fever is a challenging disease for scientists as significant further investigations are necessary. Great research opportunities are available to reach a better understanding and thus a better prevention and control of the infection.

  8. Male circumcision and HIV prevention: current knowledge and future research directions.

    Science.gov (United States)

    Bailey, R C; Plummer, F A; Moses, S

    2001-11-01

    Over the past decade, numerous epidemiological studies have reported a significant association between lack of male circumcision and risk for HIV infection, leading to recommendations for male circumcision to be added to the armamentarium of effective HIV prevention strategies. We review the epidemiological data from studies that have investigated this association, including ecological, cross-sectional/case-control, and prospective studies. We discuss problematic issues in interpreting the epidemiological data, including the presence of other sexually transmitted infections, age of circumcision, and potential confounders such as religion, cultural practices, and genital hygiene. In addition, we review studies of biological mechanisms by which the presence of the foreskin may increase HIV susceptibility, data on risks associated with the circumcision procedure, and available data on the acceptability and feasibility of introducing male circumcision in societies where it is traditionally not practised. Although the evidence in support of male circumcision as an effective HIV prevention measure is compelling, residual confounding in observational studies cannot be excluded. Taken together with concerns over the potential disinhibiting effect of male circumcision on risk behaviour, and safety of the circumcision procedure, randomised trials of male circumcision to prevent HIV infection are recommended. An individual's choice to undergo male circumcision or a community's decision to promote the practice should be made in the light of the best available scientific evidence. More knowledge is required to assist individuals and communities in making those decisions. We conclude with recommendations for future research.

  9. Family planning knowledge and current use of contraception among the Mru indigenous women in Bangladesh: a multivariate analysis

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    Islam MR

    2012-02-01

    Full Text Available M Rakibul Islam1, Gunnar Thorvaldsen21Bangladesh Agricultural University, Bangladesh; 2Norwegian Historical Data Centre, University of Tromsø, NorwayBackground: This article aims to understand the family planning (FP knowledge and current use of contraception and its predictors among women of the Mru people – the most underprivileged indigenous community in Bangladesh.Methods: In this study, 374 currently married Mru women were interviewed and selected purposively from three upazilas (administrative subdistricts of the Bandarban area, where most of the Mru people live. The association between the variables was assessed in bivariate analysis using the Chi-square test and binary logistic regression models were employed to explore the predictors of FP knowledge and current use of contraception among the Mru women.Results: Only about 40% of respondents had ever heard FP messages or about FP methods – two-fifths of the national figure (99.9%. The current use of contraception was much lower (25.1% among the Mru people than at the national level (55.8%. Among both modern and traditional methods, the contraceptive pill ranked first. About two-thirds (66.0% of married women used this method – more than two times than the national figure (28.5%. On the other hand, the prevalence of male methods was comparatively lower than at the national level. Logistic regression models revealed that place of residence, religion, age, school attendance, husband's school attendance, service provided in the community, distance to the service center, and exposure to mass media had significant effects on knowledge of FP and on use of contraception.Conclusion: Education for mothers and vernacular language-based doorstep FP programs with special emphasis on awareness are suggested for the community.Keywords: family planning, contraceptive use, the Mru, logistic regression, Bangladesh

  10. Relative Importance and Knowledge Distribution of Medicinal Plants in a Kichwa Community in the Ecuadorian Amazon

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    Brian Joseph Doyle

    2017-01-01

    Full Text Available Traditional knowledge, such as knowledge of the use of plants as medicine, influences how indigenous people manage forest resources. Gender and age-associated differences in traditional knowledge may impact forest resource management because of the traditional division of labor. We interviewed 18 men and 18 women between 9 and 74 years old in San José de Payamino, an indigenous community of the Kichwa ethnicity in the Ecuadorian Amazon, to determine if there are gender or age-associated differences in medicinal plant knowledge among the Payamino people and to identify the most important species from a sample of medicinal plants. Individuals were interviewed using a tablet that displayed images of 34 plants, which had been cited by traditional healers in the community. Quantitative analysis provided insight into the relative importance of plants in the sample as well as the distribution of medicinal plant knowledge among members of the community. The most important plants were Tradescantia zanonia and Monolena primuliflora. These plants should be considered candidates for further investigation. There was a positive correlation between age and knowledge of medicinal plants, but no significant difference between genders. Our results suggest that an interview method that relies on digital images can reveal differences in the importance of medicinal plants as well as provide insight into the distribution of traditional medical knowledge. While men and women are likely to manage forest resources similarly, younger members of the community may not have the same regard for forest resources as their elder counterparts.

  11. Sexual experience and HIV-related knowledge among Belgian university students: a questionnaire study.

    Science.gov (United States)

    Degroote, Sophie; Vogelaers, Dirk; Liefhooghe, Griet; Vermeir, Peter; Vandijck, Dominique M

    2014-05-15

    Adolescents are a risk group for acquiring sexually transmitted diseases, including HIV. Correct knowledge about transmission mechanisms is a prerequisite to taking appropriate precautions to avoid infection. This study aimed at assessing the level of HIV-related knowledge among university students as a first step in developing targeted interventions. We used a self-developed HIV knowledge questionnaire, supplemented with socio-demographic and sexual behaviour questions. The questionnaire was composed of 59 items from different existing questionnaires. It included general statements and statements about prevention, transmission and treatment of HIV. There were 357 (79.7%) female and 93 (20.3%) male participants and their median age was 20 (IQR 19-21). On average 42/59 (71.2%) questions were answered correctly, 5/59 (8.5%) were answered incorrectly and 12/59 (20.3%) were unknown . The best and worse scores were seen on the prevention questions and the treatment questions, respectively. HIV-related knowledge is higher in older students and in students with a health-related education. Students with sexual experience, with five or more partners and students who have been tested on STDs have a higher HIV-related knowledge. Knowledge on prevention and transmission of HIV is fairly good among university students and knowledge is higher among students with more sexual experience. They still have some misconceptions (e.g. HIV is spread by mosquitoes) and they are ignorant of a substantial number of statements (e.g. risk for infection through oral sex).

  12. Improving medical students' knowledge of genetic disease: a review of current and emerging pedagogical practices.

    Science.gov (United States)

    Wolyniak, Michael J; Bemis, Lynne T; Prunuske, Amy J

    2015-01-01

    Genetics is an essential subject to be mastered by health professional students of all types. However, technological advances in genomics and recent pedagogical research have changed the way in which many medical training programs teach genetics to their students. These advances favor a more experience-based education focused primarily on developing student's critical thinking skills. In this review, we examine the current state of genetics education at both the preclinical and clinical levels and the ways in which medical and pedagogical research have guided reforms to current and emerging teaching practices in genetics. We discover exciting trends taking place in which genetics is integrated with other scientific disciplines both horizontally and vertically across medical curricula to emphasize training in scientific critical thinking skills among students via the evaluation of clinical evidence and consultation of online databases. These trends will produce future health professionals with the skills and confidence necessary to embrace the new tools of medical practice that have emerged from scientific advances in genetics, genomics, and bioinformatics.

  13. Improving medical students' knowledge of genetic disease: a review of current and emerging pedagogical practices

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    Wolyniak MJ

    2015-10-01

    Full Text Available Michael J Wolyniak,1 Lynne T Bemis,2 Amy J Prunuske2 1Department of Biology, Hampden-Sydney College, Hampden-Sydney, VA, 2Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA Abstract: Genetics is an essential subject to be mastered by health professional students of all types. However, technological advances in genomics and recent pedagogical research have changed the way in which many medical training programs teach genetics to their students. These advances favor a more experience-based education focused primarily on developing student's critical thinking skills. In this review, we examine the current state of genetics education at both the preclinical and clinical levels and the ways in which medical and pedagogical research have guided reforms to current and emerging teaching practices in genetics. We discover exciting trends taking place in which genetics is integrated with other scientific disciplines both horizontally and vertically across medical curricula to emphasize training in scientific critical thinking skills among students via the evaluation of clinical evidence and consultation of online databases. These trends will produce future health professionals with the skills and confidence necessary to embrace the new tools of medical practice that have emerged from scientific advances in genetics, genomics, and bioinformatics. Keywords: genetics education, medical genetics, pedagogical practice, active learning, problem-based learning

  14. Hepatitis C in Pregnancy: Review of Current Knowledge and Updated Recommendations for Management.

    Science.gov (United States)

    Page, Charlotte M; Hughes, Brenna L; Rhee, Eleanor H J; Kuller, Jeffrey A

    2017-06-01

    An estimated 1% to 2.5% of pregnant women in the United States are infected with hepatitis C virus (HCV), which carries approximately a 6% risk of mother-to-infant transmission. The aims of this article are to review the current evidence on HCV in pregnancy and to provide updated recommendations for management. Original research articles, review articles, and guidelines on HCV in general and specifically in pregnancy were reviewed, as were drug safety profiles from the Food and Drug Administration. Pregnancy appears to have a beneficial effect on the course of maternal chronic HCV infection. However, it is associated with an increased risk of adverse fetal outcomes, including fetal growth restriction and low birth weight, and can be transmitted to the infant in utero or during the peripartum period. No perinatal intervention has been shown to reduce the risk of vertical transmission, but some may increase this risk. To date, no treatment regimens for HCV have been approved for use in pregnancy, but the new ribavirin-free, direct-acting antiviral regimens are being used with high efficacy outside pregnancy. Hepatitis C virus infection in pregnancy generally does not adversely affect maternal well-being but is associated with adverse effects on the fetus because of pregnancy complications and vertical transmission. There are currently no approved treatment regimens for HCV in pregnancy; this should be an active area of research in obstetrics.

  15. A European Perspective on Auditory Processing Disorder-Current Knowledge and Future Research Focus

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    Vasiliki (Vivian Iliadou

    2017-11-01

    Full Text Available Current notions of “hearing impairment,” as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday life that are indexed by reduced performance in other more sophisticated audiometric tests such as speech audiometry in noise or complex non-speech sound perception. This disorder, defined as “Auditory Processing Disorder” (APD or “Central Auditory Processing Disorder” is classified in the current tenth version of the International Classification of diseases as H93.25 and in the forthcoming beta eleventh version. APDs may have detrimental effects on the affected individual, with low esteem, anxiety, and depression, and symptoms may remain into adulthood. These disorders may interfere with learning per se and with communication, social, emotional, and academic-work aspects of life. The objective of the present paper is to define a baseline European APD consensus formulated by experienced clinicians and researchers in this specific field of human auditory science. A secondary aim is to identify issues that future research needs to address in order to further clarify the nature of APD and thus assist in optimum diagnosis and evidence-based management. This European consensus presents the main symptoms, conditions, and specific medical history elements that should lead to auditory processing evaluation. Consensus on definition of the disorder, optimum diagnostic pathway, and appropriate management are highlighted alongside a perspective on future research focus.

  16. Improving medical students’ knowledge of genetic disease: a review of current and emerging pedagogical practices

    Science.gov (United States)

    Wolyniak, Michael J; Bemis, Lynne T; Prunuske, Amy J

    2015-01-01

    Genetics is an essential subject to be mastered by health professional students of all types. However, technological advances in genomics and recent pedagogical research have changed the way in which many medical training programs teach genetics to their students. These advances favor a more experience-based education focused primarily on developing student’s critical thinking skills. In this review, we examine the current state of genetics education at both the preclinical and clinical levels and the ways in which medical and pedagogical research have guided reforms to current and emerging teaching practices in genetics. We discover exciting trends taking place in which genetics is integrated with other scientific disciplines both horizontally and vertically across medical curricula to emphasize training in scientific critical thinking skills among students via the evaluation of clinical evidence and consultation of online databases. These trends will produce future health professionals with the skills and confidence necessary to embrace the new tools of medical practice that have emerged from scientific advances in genetics, genomics, and bioinformatics. PMID:26604852

  17. The Search for Life on Mars - Current Knowledge, Earth Analogues, and Principal Issues

    Science.gov (United States)

    Mumma, Michael J.

    2012-01-01

    For centuries, the planet Mars has been imagined as a possible abode for life. Serious searches for life's signatures began in the 19th century via ground-based visual astronomy that stimulated a vibrant fantasy literature but little lasting scientific knowledge. Modern scientific inquiry has emphasized the search for chemical signatures of life in the soil and rocks at the planet's surface, and via biomarker gases in the atmosphere. Today, investigations are based on high-resolution spectroscopy at Earth's largest telescopes along with planet orbiting and landed space missions. Methane has assumed central importance in these searches. Living systems produce more than 900/0 of Earth's atmospheric methane; the balance is of geochemical origin. Abundant methane is not expected in an oxidizing atmosphere such as Mars', and its presence would imply recent release - whether biological or geochemical. F or that reason, the quest for methane on Mars has been a continuing thread in the fabric of searches conducted since 1969. I will review aspects of the discovery and distribution of methane on Mars, and will mention ongoing extended searches for clues to its origin and destruction. On Earth, hydrogen (generated via serpentinization or radiolysis of water) provides an important 'fuel' for carbonate-reducing and sulphate-reducing biota (CH4 and H2S producers, respectively). Several such communities are known to reside at depth in continental domains (e.g., Lidy Hot Springs, Idaho; Witwatersrand Basin, S. Africa). If similar conditions exist in favourable locations on Mars, organisms similar to these could likely prosper there. Geologic (abiotic) production will also be mentioned, especially abiotic methane production associated with low-temperature serpentinization (e.g., terrestrial ophiolites). It is vitally important to pursue evidence for geochemical and biological production with equal vigour and intellectual weight lest unwanted and unintended bias contaminate the

  18. Literacy Outcomes in Deaf Students with Cochlear Implants: Current State of the Knowledge

    Science.gov (United States)

    Mayer, Connie; Trezek, Beverly J.

    2018-01-01

    The purpose of this paper is to examine the available peer-reviewed research regarding literacy achievement in deaf children with cochlear implants. A related goal is to identify gaps in the empirical literature and suggest directions for future research. Included in this review are studies that exclusively report reading and writing outcomes for…

  19. White-nose syndrome in bats: an overview of current knowledge for land managers

    Science.gov (United States)

    Roger W. Perry

    2013-01-01

    White-nose syndrome recently emerged as a disease affecting bats that hibernate in caves and abandoned mines during winter. This disease is caused by the fungus Pseudogymnoascus destructans, and has caused the death of millions of bats in the Eastern United States and Canada. This fungus grows in relatively cold conditions with high humidity, which...

  20. Breast Cancer Screening in Women with Learning Disabilities: Current Knowledge and Considerations

    Science.gov (United States)

    Willis, Diane S.; Kennedy, Catriona M.; Kilbride, Lynn

    2008-01-01

    As people with learning disabilities now live longer, they will experience the same age-related illnesses as the general population and cancer is a prime example of this. In women, cancer screening is used to detect early on-set of cancer of the breast and abnormalities of the cervix which might, if left untreated, develop into cancer.…

  1. KNOWLEDGE AND INNOVATION - ESSENTIAL FACTORS FOR OVERCOMING THE CURRENT ECONOMIC IMPASSE

    Directory of Open Access Journals (Sweden)

    Ramona Frunză

    2010-09-01

    Full Text Available Human resource is currently the most valuable wealth of a nation and carries with it the most important principle of development; it is about innovation, without which competitiveness is unthinkable. Romania is part of the “catching–up” group of countries in innovation. In order to assume new responsibilities and to prepare for the competition with other European countries and not only, manyreforms and changes is necessary. Assuming these premises, in this paper, our intention is to analyze the situation of innovation at EUlevel and to see at what chapters our authorities must to work harder to equalize the other states from the Western European states. This thing is absolutely necessary because, now, when our country makes part from EU, it needs to invest in human resources through better education, skills and support.

  2. [Pathological buying. A review of the current knowledge regarding this condition of behavioral excess].

    Science.gov (United States)

    Müller, A; de Zwaan, M

    2010-04-01

    Compulsive buying is characterized by frequent excessive purchasing of items that are primarily not needed or used. The compulsive buying behavior results in mental, social, financial and often legal problems. Although compulsive buying affects a significant percentage of the general population and has received increasing attention in research, it has largely been ignored in clinical practice. Compulsive buying disorder is currently conceptualized as an"impulse control disorder not otherwise specified". However, the appropriate classification continues to be debated. Compulsive buying is associated with significant psychiatric co-morbidity, especially with depressive, anxiety, obsessive-compulsive, substance use, personality, and other impulse control disorders. Small controlled trials failed to confirm the efficacy of antidepressants in the treatment of compulsive buying disorder, whereas early evidence suggests that cognitive behavioral therapy is helpful in alleviating compulsive buying symptoms. Further research is needed to establish a better understanding of etiology, classification, and treatment strategies.

  3. Nitric oxide in plants: an assessment of the current state of knowledge

    DEFF Research Database (Denmark)

    Mur, Luis A J; Mandon, Julien; Persijn, Stefan

    2013-01-01

    Background and aims After a series of seminal works during the last decade of the 20th century nitric oxide (NO) is now firmly placed in the pantheon of plant signals. NO acts in plant-microbe interactions, responses to abiotic stress, stomatal regulation and a range of developmental processes...... of NO production from DEANO (diethylamine nitric oxide), S-nitrosoglutathione (GSNO) and sodium nitroprusside (SNP) following infiltration of tobacco leaves which could aid workers in their experiments. Further, based on current data it is difficult to define a bespoke plant NO signalling pathway, but rather....... By considering the recent advances in plant NO biology, this review will highlight certain key aspects that require further attention. Scope and conclusions The following questions will be considered. Whilst cytosolic nitrate reductase is an important source of NO, the contributions of other mechanisms...

  4. A European Perspective on Auditory Processing Disorder-Current Knowledge and Future Research Focus

    DEFF Research Database (Denmark)

    IIiadou, Vasiliki; Ptok, Martin; Grech, Helen

    2017-01-01

    Current notions of "hearing impairment," as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday life that are indexed by reduced performance in other...... of diseases as H93.25 and in the forthcoming beta eleventh version. APDs may have detrimental effects on the affected individual, with low esteem, anxiety, and depression, and symptoms may remain into adulthood. These disorders may interfere with learning per se and with communication, social, emotional......, and academic-work aspects of life. The objective of the present paper is to define a baseline European APD consensus formulated by experienced clinicians and researchers in this specific field of human auditory science. A secondary aim is to identify issues that future research needs to address in order...

  5. [Formula: see text]Current knowledge on motor disorders in children with autism spectrum disorder (ASD).

    Science.gov (United States)

    Paquet, A; Olliac, B; Golse, B; Vaivre-Douret, L

    2016-01-01

    Motor symptomatology in autism is currently poorly understood, and still not included in the autism spectrum disorder (ASD) diagnostic criteria, although some studies suggest the presence of motor disturbances in this syndrome. We provide here a literature review on early motor symptoms in autism, focusing on studies on psychomotor issues (tone, postural control, manual dexterity, handedness, praxis). The approach adopted in research to study altered motor behaviors is generally global and there is no detailed semiology of the motor or neuromotor disorders observed in people with ASD. This global approach does not enable understanding of the neuro-developmental mechanisms involved in ASD. Identification of clinical neuro-psychomotor profiles in reference to a standard would help to better understand the origin and the nature of the disorders encountered in ASD, and would thus give new directions for treatment.

  6. Chemical pollution in the Arctic and Sub-Arctic marine ecosystems: an overview of current knowledge

    Energy Technology Data Exchange (ETDEWEB)

    Savinova, T N; Gabrielsen, G W; Falk-Petersen, S

    1995-02-01

    This report is part of a research project in the framework of the Norwegian-Russian Environmental Cooperation, which was initiated in 1991 to elucidate the present status of environmental contaminants in the highly sensitive Arctic aquatic ecosystem, with special focus on sea birds. Although these ecosystems are the least polluted areas in the world, they are contaminated. The main pathways of contamination into Arctic and sub-Arctic marine ecosystems are atmospheric transport, ocean currents and rivers and in some areas, dumping and ship accidents. A literature survey reveals: (1) there is a lack of data from several trophic levels, (2) previous data are difficult to compare with recent data because of increased quality requirement, (3) not much has been done to investigate the effects of contaminants on the cellular level, at individual or population levels. 389 refs., 7 figs., 32 tabs.

  7. Current knowledge and pending challenges in zoonosis caused by Mycobacterium bovis: a review.

    Science.gov (United States)

    Pérez-Lago, Laura; Navarro, Yurena; García-de-Viedma, Darío

    2014-10-01

    Mycobacterium bovis is both the causative agent of bovine tuberculosis (TB) and a zoonotic pathogen. In humans, considerably fewer cases of TB are caused by M. bovis than M. tuberculosis; nevertheless, diagnostic limitations mean that currently available data on prevalence grossly underestimate the true dimension of the problem. The routes of transmission from animals to humans are well known and include direct exposure to infected animals or consumption of contaminated animal products. Application of fingerprinting tools facilitates analysis of the molecular epidemiology of M. bovis in animal-to-human and human-to-human transmission. Apart from cattle and M. bovis, other animal species and members within the M. tuberculosis complex can contribute to the zoonosis. Improvements in diagnostic techniques, application of more advanced discriminatory genotyping tools, and collaboration between veterinary and human health care researchers are key to our understanding of this zoonosis. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Biological variation in musculoskeletal injuries: current knowledge, future research and practical implications.

    Science.gov (United States)

    Collins, Malcolm; September, Alison V; Posthumus, Michael

    2015-12-01

    Evidence from familial and genetic association studies have reported that DNA sequence variants play an important role, together with non-genetic factors, in the aetiology of both exercise-associated and occupational-associated acute and chronic musculoskeletal soft tissue injuries. The associated variants, which have been identified to date, may contribute to the interindividual variation in the structure and, by implication, mechanical properties of the collagen fibril and surrounding matrix within musculoskeletal soft tissues, as well as their response to mechanical loading and other stimuli. Future work should focus on the establishment of multidisciplinary international consortia for the identification of biologically relevant variants involved in modulating injury risk. These consortia will improve the limitations of the published hypothesis-driven genetic association studies, since they will allow resources to be pooled in recruiting large well-characterised cohorts required for whole-genome screening. Finally, clinicians and coaches need to be aware that many direct-to-consumer companies are currently marketing genetic tests directly to athletes without it being requested by an appropriately qualified healthcare professional, and without interpretation alongside other clinical indicators or lifestyle factors. These specific genetic tests are premature and are not necessarily required to evaluate susceptibility to musculoskeletal soft tissue injury. Current practice should rather consider susceptibility through known risk factors such as a positive family history of a specific injury, a history of other tendon and/or ligament injuries and participation in activities associated with the specific musculoskeletal injuries. Potential susceptible athletes may then be individually managed to reduce their risk profile. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  9. Text mining of cancer-related information: review of current status and future directions.

    Science.gov (United States)

    Spasić, Irena; Livsey, Jacqueline; Keane, John A; Nenadić, Goran

    2014-09-01

    This paper reviews the research literature on text mining (TM) with the aim to find out (1) which cancer domains have been the subject of TM efforts, (2) which knowledge resources can support TM of cancer-related information and (3) to what extent systems that rely on knowledge and computational methods can convert text data into useful clinical information. These questions were used to determine the current state of the art in this particular strand of TM and suggest future directions in TM development to support cancer research. A review of the research on TM of cancer-related information was carried out. A literature search was conducted on the Medline database as well as IEEE Xplore and ACM digital libraries to address the interdisciplinary nature of such research. The search results were supplemented with the literature identified through Google Scholar. A range of studies have proven the feasibility of TM for extracting structured information from clinical narratives such as those found in pathology or radiology reports. In this article, we provide a critical overview of the current state of the art for TM related to cancer. The review highlighted a strong bias towards symbolic methods, e.g. named entity recognition (NER) based on dictionary lookup and information extraction (IE) relying on pattern matching. The F-measure of NER ranges between 80% and 90%, while that of IE for simple tasks is in the high 90s. To further improve the performance, TM approaches need to deal effectively with idiosyncrasies of the clinical sublanguage such as non-standard abbreviations as well as a high degree of spelling and grammatical errors. This requires a shift from rule-based methods to machine learning following the success of similar trends in biological applications of TM. Machine learning approaches require large training datasets, but clinical narratives are not readily available for TM research due to privacy and confidentiality concerns. This issue remains the main

  10. Toxoplasmosis Preventive Behavior and Related Knowledge among Saudi Pregnant Women: An Exploratory Study

    Science.gov (United States)

    Amin, Tarek Tawfik; Ali, Mohamed Nabil Al; Alrashid, Ahmed Abdulmohsen; Ahmed Al-Agnam, Amena; Al Sultan, Amina Abdullah

    2013-01-01

    Introduction: Many cases of congenital toxoplasmosis can be prevented provided that pregnant women following hygienic measures to avert risk of infection and to reduce severity of the condition if primary prevention failed. Objectives: This descriptive exploratory study aimed to assess the risk behavior and knowledge related to toxoplasmoisis among Saudi pregnant women attending primary health care centers (PHCs) in Al Hassa, Saudi Arabia and to determine socio-demographic characteristics related to risk behavior and knowledge. Methods: All Saudi pregnant women attending antenatal care at randomly selected six urban and four rural PHCs were approached. Those agreed to participate were interviewed using a pre-tested structured questionnaire collecting data regarding socio-demographic, obstetric history, toxoplasmosis risk behaviors and related knowledge. Results: Of the included pregnant women, 234 (26.8%) have fulfilled the criteria for toxoplasmosis preventive behavior recommended by Centers for Disease Prevention and Control to prevent congenital toxoplasmosis, while 48.9% reported at least one risk behavior and 24.3% reported ≥ two risk behaviors. Logistic regression model revealed that pregnant women aged 20 to toxoplasmosis preventive behavior. Toxoplasmosis-related knowledge showed that many women had identified the role of cats in disease transmission while failed to identify other risk factors including consumption of undercooked meats, unwashed fruits and vegetables, and contacting with soil. Predictors for pregnant women to be knowledgeable towards toxoplasmosis included those aged 30 to toxoplasmosis (OR=2.08) as reveled by multivariate regression model. Conclusion: Pregnant women in Al Hasas, Saudi Arabia, are substantially vulnerable to toxoplasmosis infection as they are lacking the necessary preventive behavior. A sizable portion have no sufficient knowledge for primary prevention of congenital toxoplasmosis, health education at primary care is

  11. A protein relational database and protein family knowledge bases to facilitate structure-based design analyses.

    Science.gov (United States)

    Mobilio, Dominick; Walker, Gary; Brooijmans, Natasja; Nilakantan, Ramaswamy; Denny, R Aldrin; Dejoannis, Jason; Feyfant, Eric; Kowticwar, Rupesh K; Mankala, Jyoti; Palli, Satish; Punyamantula, Sairam; Tatipally, Maneesh; John, Reji K; Humblet, Christine

    2010-08-01

    The Protein Data Bank is the most comprehensive source of experimental macromolecular structures. It can, however, be difficult at times to locate relevant structures with the Protein Data Bank search interface. This is particularly true when searching for complexes containing specific interactions between protein and ligand atoms. Moreover, searching within a family of proteins can be tedious. For example, one cannot search for some conserved residue as residue numbers vary across structures. We describe herein three databases, Protein Relational Database, Kinase Knowledge Base, and Matrix Metalloproteinase Knowledge Base, containing protein structures from the Protein Data Bank. In Protein Relational Database, atom-atom distances between protein and ligand have been precalculated allowing for millisecond retrieval based on atom identity and distance constraints. Ring centroids, centroid-centroid and centroid-atom distances and angles have also been included permitting queries for pi-stacking interactions and other structural motifs involving rings. Other geometric features can be searched through the inclusion of residue pair and triplet distances. In Kinase Knowledge Base and Matrix Metalloproteinase Knowledge Base, the catalytic domains have been aligned into common residue numbering schemes. Thus, by searching across Protein Relational Database and Kinase Knowledge Base, one can easily retrieve structures wherein, for example, a ligand of interest is making contact with the gatekeeper residue.

  12. Knowledge, Attitude, and Behaviors Related to Eating Out among University Students in China

    Directory of Open Access Journals (Sweden)

    Ping Hu

    2016-07-01

    Full Text Available In many countries the frequency of eating out has steadily increased over the last few decades, and this behavioris often associated with unhealthy dietary patterns. This study aimed to describe the levels of knowledge, attitude, and behaviors (KAB related to eating out among university students. A cross-sectional study was conducted in the college town in Chongqing, China with a total of 1634 participants. The mean eating out related KAB scores were: knowledge 11.5 ± 2.9, attitude 17.0 ± 2.8, and behaviors 24.2 ± 4.8 (possible total scores: 20, 24, 40 respectively. As the level of knowledge increased, the percentage of highly satisfactory attitude and behaviors increased. Only 10% of the participants did not eat out for lunch and dinner during weekends in the last month. Gender, ethnicity, mother’s education, monthly boarding expenses, living place during the study, and the frequency of eating out for breakfast were statistically associated with the scores of KAB. In conclusion, Chinese junior students had poor knowledge of and behaviors towards eating out and ate out frequently. Educational interventionsto improve knowledge related eating out are needed in order to promote healthy eating out behaviors among Chinese university students.

  13. Knowledge, Attitude, and Behaviors Related to Eating Out among University Students in China.

    Science.gov (United States)

    Hu, Ping; Huang, Wenjie; Bai, Ruixue; Zhang, Fan; Sharma, Manoj; Shi, Zumin; Xiao, Xiaoqiu; Abdullah, Abu S; Zhao, Yong

    2016-07-12

    In many countries the frequency of eating out has steadily increased over the last few decades, and this behavioris often associated with unhealthy dietary patterns. This study aimed to describe the levels of knowledge, attitude, and behaviors (KAB) related to eating out among university students. A cross-sectional study was conducted in the college town in Chongqing, China with a total of 1634 participants. The mean eating out related KAB scores were: knowledge 11.5 ± 2.9, attitude 17.0 ± 2.8, and behaviors 24.2 ± 4.8 (possible total scores: 20, 24, 40 respectively). As the level of knowledge increased, the percentage of highly satisfactory attitude and behaviors increased. Only 10% of the participants did not eat out for lunch and dinner during weekends in the last month. Gender, ethnicity, mother's education, monthly boarding expenses, living place during the study, and the frequency of eating out for breakfast were statistically associated with the scores of KAB. In conclusion, Chinese junior students had poor knowledge of and behaviors towards eating out and ate out frequently. Educational interventionsto improve knowledge related eating out are needed in order to promote healthy eating out behaviors among Chinese university students.

  14. Current knowledge on exocrine glands in carabid beetles: structure, function and chemical compounds

    Directory of Open Access Journals (Sweden)

    Anita Giglio

    2011-05-01

    Full Text Available Many exocrine products used by ground beetles are pheromones and allomones that regulate intra- and interspecific interactions and contribute to their success in terrestrial ecosystems. This mini-review attempts to unify major themes related to the exocrine glands of carabid beetles. Here we report on both glandular structures and the role of secretions in carabid adults, and that little information is available on the ecological significance of glandular secretions in pre-imaginal stages.

  15. Current knowledge on exocrine glands in carabid beetles: structure, function and chemical compounds.

    Science.gov (United States)

    Giglio, Anita; Brandmayr, Pietro; Talarico, Federica; Brandmayr, Tullia Zetto

    2011-01-01

    Many exocrine products used by ground beetles are pheromones and allomones that regulate intra- and interspecific interactions and contribute to their success in terrestrial ecosystems. This mini-review attempts to unify major themes related to the exocrine glands of carabid beetles. Here we report on both glandular structures and the role of secretions in carabid adults, and that little information is available on the ecological significance of glandular secretions in pre-imaginal stages.

  16. Impact of radioactivity on the environment: problems, state of current knowledge and approaches for identification of radioprotection criteria

    International Nuclear Information System (INIS)

    Brechignac, F.

    2001-01-01

    There is currently a revitalized concern about the potential impact of ionizing radiation on the environment that calls for the construction of a system ensuring an adequate radioprotection of the non-human biota and their associated biotopes. This paper first sets the context of the problem both, with respect to the general philosophy of environmental protection as a whole, but also with respect to the consideration of the environment achieved so far in the purpose of human radioprotection. The current accumulated knowledge on the effects of ionizing radiation to biota (fauna and flora) is then briefly reviewed, encompassing effects at individual and community/ecosystem level, situations of acute and chronic exposure to high and low doses, finally leading to the identification of the most critical gaps in scientific knowledge: effects of mixed low dose rates in chronic exposure to communities and ecosystems. The most significant current international efforts towards the identification of environmental radioprotection criteria and standards are finally presented along with some relevant national examples. (author)

  17. An investigation of Saudi Arabian MR radiographers' knowledge and confidence in relation to MR image-quality-related errors

    International Nuclear Information System (INIS)

    Alsharif, W.; Davis, M.; McGee, A.; Rainford, L.

    2017-01-01

    Objective: To investigate MR radiographers' current knowledge base and confidence level in relation to quality-related errors within MR images. Method: Thirty-five MR radiographers within 16 MRI departments in the Kingdom of Saudi Arabia (KSA) independently reviewed a prepared set of 25 MR images, naming the error, specifying the error-correction strategy, scoring how confident they were in recognising this error and suggesting a correction strategy by using a scale of 1–100. The datasets were obtained from MRI departments in the KSA to represent the range of images which depicted excellent, acceptable and poor image quality. Results: The findings demonstrated a low level of radiographer knowledge in identifying the type of quality errors and when suggesting an appropriate strategy to rectify those errors. The findings show that only (n = 7) 20% of the radiographers could correctly name what the quality errors were in 70% of the dataset, and none of the radiographers correctly specified the error-correction strategy in more than 68% of the MR datasets. The confidence level of radiography participants in their ability to state the type of image quality errors was significantly different (p < 0.001) for who work in different hospital types. Conclusion: The findings of this study suggest there is a need to establish a national association for MR radiographers to monitor training and the development of postgraduate MRI education in Saudi Arabia to improve the current status of the MR radiographers' knowledge and direct high quality service delivery. - Highlights: • MR radiographers recognised the existence of the image quality related errors. • A few MR radiographers were able to correctly identify which image quality errors were being shown. • None of MR radiographers were able to correctly specify error-correction strategy of the image quality errors. • A low level of knowledge was demonstrated in identifying and rectify image quality errors.

  18. A synthesis of current knowledge on forests and carbon storage in the United States.

    Science.gov (United States)

    McKinley, Duncan C; Ryan, Michael G; Birdsey, Richard A; Giardina, Christian P; Harmon, Mark E; Heath, Linda S; Houghton, Richard A; Jackson, Robert B; Morrison, James F; Murray, Brian C; Patakl, Diane E; Skog, Kenneth E

    2011-09-01

    Using forests to mitigate climate change has gained much interest in science and policy discussions. We examine the evidence for carbon benefits, environmental and monetary costs, risks and trade-offs for a variety of activities in three general strategies: (1) land use change to increase forest area (afforestation) and avoid deforestation; (2) carbon management in existing forests; and (3) the use of wood as biomass energy, in place of other building materials, or in wood products for carbon storage. We found that many strategies can increase forest sector carbon mitigation above the current 162-256 Tg C/yr, and that many strategies have co-benefits such as biodiversity, water, and economic opportunities. Each strategy also has trade-offs, risks, and uncertainties including possible leakage, permanence, disturbances, and climate change effects. Because approximately 60% of the carbon lost through deforestation and harvesting from 1700 to 1935 has not yet been recovered and because some strategies store carbon in forest products or use biomass energy, the biological potential for forest sector carbon mitigation is large. Several studies suggest that using these strategies could offset as much as 10-20% of current U.S. fossil fuel emissions. To obtain such large offsets in the United States would require a combination of afforesting up to one-third of cropland or pastureland, using the equivalent of about one-half of the gross annual forest growth for biomass energy, or implementing more intensive management to increase forest growth on one-third of forestland. Such large offsets would require substantial trade-offs, such as lower agricultural production and non-carbon ecosystem services from forests. The effectiveness of activities could be diluted by negative leakage effects and increasing disturbance regimes. Because forest carbon loss contributes to increasing climate risk and because climate change may impede regeneration following disturbance, avoiding

  19. A study of HIV/AIDS related knowledge, attitude and behaviors among female sex workers in Shanghai China

    Directory of Open Access Journals (Sweden)

    Cai Yong

    2010-06-01

    Full Text Available Abstract Background China is currently facing a rapid and widespread increase in human immunodeficiency virus (HIV/acquired immunodeficiency syndrome (AIDS. The activities of female sex workers (FSWs have contributed to the mounting epidemic of HIV/AIDS and other sexually transmitted diseases (STDs. Therefore, this study aimed to assess the HIV/AIDS-related knowledge, attitude and risk behaviors among FSWs operating in Shanghai China. Methods A cross-sectional study was conducted in five districts of Shanghai, including three suburbs and two downtown locales. We adopted a cluster randomized sampling method to obtain ten geographic sites which consisted of one or more communities/villages proximal to a location where FSWs were accessible. A total of 324 FSWs from 109 Xitou Fang, massage parlors and hair salons who explicitly provided sexual services were enrolled in the study. Each participant completed a questionnaire survey and interview aimed to collect information on the individual's knowledge, attitude, and behaviors associated with risk for HIV/AIDs. Results The overall correct answer rate of HIV/AIDS-related knowledge was 60.8%, and the knowledge of FSWs from downtown areas was significantly higher than those from suburban areas (P P Conclusions Based on the findings from our survey, we advise that promotion of HIV/AIDS-related knowledge be targeted towards FSWs in Shanghai, especially those operating in the suburbs. HIV prevention efforts, such as urging constant condom usage with both clients and steady partners, should be sustained and reinforced among the female sex workers population.

  20. A study of HIV/AIDS related knowledge, attitude and behaviors among female sex workers in Shanghai China.

    Science.gov (United States)

    Cai, Yong; Shi, Rong; Shen, Tian; Pei, Bei; Jiang, Xueqin; Ye, Xiuxia; Xu, Gang; Li, Shenghui; Huang, Hong; Shang, Meili

    2010-06-28

    China is currently facing a rapid and widespread increase in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). The activities of female sex workers (FSWs) have contributed to the mounting epidemic of HIV/AIDS and other sexually transmitted diseases (STDs). Therefore, this study aimed to assess the HIV/AIDS-related knowledge, attitude and risk behaviors among FSWs operating in Shanghai China. A cross-sectional study was conducted in five districts of Shanghai, including three suburbs and two downtown locales. We adopted a cluster randomized sampling method to obtain ten geographic sites which consisted of one or more communities/villages proximal to a location where FSWs were accessible. A total of 324 FSWs from 109 Xitou Fang, massage parlors and hair salons who explicitly provided sexual services were enrolled in the study. Each participant completed a questionnaire survey and interview aimed to collect information on the individual's knowledge, attitude, and behaviors associated with risk for HIV/AIDs. The overall correct answer rate of HIV/AIDS-related knowledge was 60.8%, and the knowledge of FSWs from downtown areas was significantly higher than those from suburban areas (P use of condoms was 33.6%. Condom slippage or breakage was reported as having occurred at least once by 51.2% of the FSWs. FSWs from suburban areas were found to more often engage in high-risk behaviors, including oral and anal sex, than those from downtown areas (P condom usage with these partners were lower (34.3%). Based on the findings from our survey, we advise that promotion of HIV/AIDS-related knowledge be targeted towards FSWs in Shanghai, especially those operating in the suburbs. HIV prevention efforts, such as urging constant condom usage with both clients and steady partners, should be sustained and reinforced among the female sex workers population.

  1. Health-related beliefs and consumer knowledge as determinants of fish consumption

    DEFF Research Database (Denmark)

    Pieniak, Zuzanna; Verbeke, Wim; Scholderer, Joachim

    2010-01-01

    samples from Belgium, the Netherlands, Denmark, Poland and Spain. The sample consisted of 4786 respondents, aged 18-84 years, who were responsible for food purchasing and cooking in the household. Results: European consumers had a very strong belief that eating fish is healthy. Consumers' belief......' knowledge. Conclusions: The findings of the present study suggest that communication should focus on health-related benefits other than fish consumption alone. Communicating that eating fish is healthy and stressing the health benefits of fish alone, as is still commonly performed (e.g. in generic promotion...... that eating fish is healthy, their interest in healthy eating and objective fish-related nutrition knowledge, positively, but only weakly, influenced fish consumption frequency. Subjective knowledge was found to be a stronger predictor of fish consumption than the previously noted factors. Age and education...

  2. Bacterial Diseases of Bananas and Enset: Current State of Knowledge and Integrated Approaches Toward Sustainable Management

    Directory of Open Access Journals (Sweden)

    Guy Blomme

    2017-07-01

    Full Text Available Bacterial diseases of bananas and enset have not received, until recently, an equal amount of attention compared to other major threats to banana production such as the fungal diseases black leaf streak (Mycosphaerella fijiensis and Fusarium wilt (Fusarium oxysporum f. sp. cubense. However, bacteria cause significant impacts on bananas globally and management practices are not always well known or adopted by farmers. Bacterial diseases in bananas and enset can be divided into three groups: (1 Ralstonia-associated diseases (Moko/Bugtok disease caused by Ralstonia solanacearum and banana blood disease caused by R. syzygii subsp. celebesensis; (2 Xanthomonas wilt of banana and enset, caused by Xanthomonas campestris pv. musacearum and (3 Erwinia-associated diseases (bacterial head rot or tip-over disease Erwinia carotovora ssp. carotovora and E. chrysanthemi, bacterial rhizome and pseudostem wet rot (Dickeya paradisiaca formerly E. chrysanthemi pv. paradisiaca. Other bacterial diseases of less widespread importance include: bacterial wilt of abaca, Javanese vascular wilt and bacterial fingertip rot (probably caused by Ralstonia spp., unconfirmed. This review describes global distribution, symptoms, pathogenic diversity, epidemiology and the state of the art for sustainable disease management of the major bacterial wilts currently affecting banana and enset.

  3. Bruxism: overview of current knowledge and suggestions for dental implants planning.

    Science.gov (United States)

    Manfredini, Daniele; Bucci, Marco Brady; Sabattini, Vincenzo Bucci; Lobbezoo, Frank

    2011-10-01

    Bruxism is commonly considered a detrimental motor activity, potentially causing overload of the stomatognathic structures and representing a risk factor for dental implant survival. The available literature does not provide evidence-based guidelines for the management of bruxers undergoing implant-retained restorations. The present paper reviewed current concepts on bruxism etiology, diagnosis and management, underlining its effects on dental implants in an attempt to provide clinically useful suggestions based on scientifically sound data. Unfortunately, very little data exists on the subject of a cause-and-effect relationship between bruxism and implant failure, to the point that expert opinions and cautionary approaches are still considered the best available sources for suggesting good practice indicators. By including experimental literature data on the effects of different types of occlusal loading on peri-implant marginal bone loss along with data from studies investigating the intensity of the forces transmitted to the bone itself during tooth-clenching and tooth-grinding activities, the authors were able to compile the suggestions presented here for prosthetic implant rehabilitations in patients with bruxism.

  4. Development of oral food-grade delivery systems: current knowledge and future challenges.

    Science.gov (United States)

    Benshitrit, Revital Cohen; Levi, Carmit Shani; Tal, Sharon Levi; Shimoni, Eyal; Lesmes, Uri

    2012-01-01

    In recent years there has been an increasing interest in the development of new and efficient oral food delivery systems as tools to prevent disease and promote human health and well-being. Such vehicles are sought to protect bioactive ingredients added to food while controlling and targeting their release as they pass through the human gastrointestinal tract (GIT). This review aims to summarize the key concepts of food delivery systems, their characterization and evaluation. Particularly, evaluation of their performance within the human GIT is discussed. To this end an overview of several in vivo and in vitro methods currently applied for the study of such systems is given. Although considered to be still in its infancy, this promising field of research is likely to infiltrate into real products through rational design. In order for such efforts to materialize into real products some challenges still need to be met and are discussed herein. Overall, it seems that adopting a comprehensive pharmacological approach and relevant cutting edge tools are likely to facilitate innovations and help elucidate and perhaps tailor delivery systems' behavior in the human GIT.

  5. Normal and abnormal development of the kidney: a clinician's interpretation of current knowledge.

    Science.gov (United States)

    Glassberg, Kenneth I

    2002-06-01

    The recent basic science literature is replete with new discoveries in the molecular genetics of renal development. However, little of this information has filtered into urological textbooks and journals. An effort is made herein to integrate these new findings and propose a more sophisticated blueprint of renal development than the one traditionally taught in medical school and residency. To accomplish this goal the author offers simple definitions and interpretations of complicated terms and events, and points out how maldevelopment results when mutations take place. A review of recent advances in the molecular genetics of renal development and maldevelopment was done. Renal metanephric development results from the expression of many genes in the ureteral bud and metanephric blastema with each sending messages to the other to induce organogenesis. Currently an understanding of normal renal organogenesis stems from a study of disease states resulting from perturbations in molecular genetics. In turn, a better understanding of normal renal organogenesis facilitates an understanding of how dysplasia, hypoplasia, cystic disease and tumors develop when molecular genetics go awry. For each form of renal dysgenesis and for most renal tumors 1 or more gene defects are eventually identified. The young urologist based in these new discoveries would be better prepared to make the breakthroughs in the future that are necessary for advancing the prevention and management of these conditions.

  6. Patterns of Disengagement from Violent Extremism: A Stocktaking of Current Knowledge and Implications for Counterterrorism

    DEFF Research Database (Denmark)

    Dalgaard-Nielsen, Anja

    2018-01-01

    This chapter takes stock of what we do and do not know from primary sources about individuals’ disengagement from violent extremism. It points to three broad patterns: doubts related to the binary nature of the extremist world view, disappointment with peers or leaders, and changing personal...... priorities. The chapter shows how, for example, first-hand exposure to extremist violence or being condemned by mainstream society can either reinforce radicalization or expedite disengagement and argues that one-size-fits-all counterterrorism measures should be supplanted by a differentiated approach...

  7. Current knowledge of environmental exposure in children during the sensitive developmental periods

    Directory of Open Access Journals (Sweden)

    Norma Helena Perlroth

    2017-01-01

    Full Text Available Objective: This study aims to identify the scientific evidence on the risks and effects of exposure to environmental contaminants in children during sensitive developmental periods. Data source: The search was performed in the Bireme database, using the terms: children's health, environmental exposure, health vulnerability, toxicity pathways and developmental disabilities in the LILACS, MEDLINE and SciELO systems. Data synthesis: Children differ from adults in their unique physiological and behavioral characteristics and the potential exposure to risks caused by several threats in the environment. Exposure to toxic agents is analyzed through toxicokinetic processes in the several systems and organs during the sensitive phases of child development. The caused effects are reflected in the increased prevalence of congenital malformations, diarrhea, asthma, cancer, endocrine and neurological disorders, among others, with negative impacts throughout adult life. Conclusion: To identify the causes and understand the mechanisms involved in the genesis of these diseases is a challenge for science, as there is still a lack of knowledge on children's susceptibility to many environmental contaminants. Prevention policies and more research on child environmental health, improving the recording and surveillance of environmental risks to children's health, should be an ongoing priority in the public health field. Resumo: Objetivo: O presente estudo busca identificar as evidências científicas sobre os riscos e efeitos da exposição de contaminantes ambientais no organismo infantil durante os períodos sensíveis de seu desenvolvimento. Fonte de dados: As pesquisas foram realizadas pelo banco de dados da Bireme, com os termos children's health, environmental exposure, health vulnerability, toxicity pathways and developmental disabilities nos sistemas LILACS, MEDLINE e SciELO. Síntese de dados: A criança difere do adulto por suas características singulares

  8. Interpersonal relations and nurses' job satisfaction through knowledge and usage of relational skills.

    Science.gov (United States)

    Lapeña-Moñux, Yolanda Raquel; Cibanal-Juan, Luis; Maciá-Soler, M Loreto; Orts-Cortés, M Isabel; Pedraz-Marcos, Azucena

    2015-11-01

    Many interpersonal labor disputes stem from the lack of communication skills and the relational problems in the interactions between health professionals. A qualitative study was conducted in a Spanish hospital in order to get to know how the communicative interaction between hospital nurses is like in relation to the nurses' interpersonal interaction and communication skills developed in their working relationships. Twenty-one hospital nurses between 29 and 55 years old, working in different wards, were interviewed. Open-ended interview discourses were transcribed verbatim and analyzed using qualitative content analysis. The following four key themes were analyzed: communication and sender; communication and awareness of who has the problem; non-verbal communication; communication and recipient. The results of this study highlight the need to broaden nurses' relational-communication skills in order to increase job satisfaction. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Longitudinal relations between adolescent and parental behaviors, parental knowledge, and internalizing behaviors among urban adolescents.

    Science.gov (United States)

    Garthe, Rachel C; Sullivan, Terri; Kliewer, Wendy

    2015-04-01

    High prevalence rates of depression and anxiety among adolescents underscore the importance of identifying parental and adolescent behaviors that may lessen the risk for these outcomes. Previous research has shown that parental acceptance, parental knowledge, and child disclosure are negatively associated with internalizing behaviors. It is also important to explore the impact of internalizing behaviors on these parental and child constructs. The current study examined longitudinal relationships between parental acceptance, parental knowledge, child disclosure, and internalizing symptoms across a one-year time period. Participants were 358 adolescents (54 % female) and their primary caregivers, who were primarily African American (92 %). Parents and adolescents provided data through face-to-face interviews. Results showed that parental knowledge and parental acceptance predicted child disclosure, and child disclosure predicted parental knowledge one year later. Higher levels of parental acceptance predicted lower levels of adolescent-reported depressive symptoms, while higher levels of parental report of adolescents' internalizing symptoms predicted lower levels of parental knowledge. No differences in the strength of these relationships were found across grade or gender. These findings highlight the role of the adolescent's perceived acceptance by parents in promoting children's disclosure, and the benefits of parental acceptance in decreasing depressive symptoms over time. Overall, these results show the impact that both adolescent and parental behaviors and internalizing behaviors have on each other across time.

  10. Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases

    Energy Technology Data Exchange (ETDEWEB)

    Zilkens, Christoph; Krauspe, Ruediger; Bittersohl, Bernd [University of Duesseldorf, Medical Faculty, Department of Orthopedic Surgery, Duesseldorf (Germany); Tiderius, Carl Johann [Lund University Hospital, Department of Orthopedic Surgery, Lund (Sweden)

    2015-08-15

    Accurate assessment of early hip joint cartilage alterations may help optimize patient selection and follow-up of hip joint preservation surgery. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is sensitive to the glycosaminoglycan content in cartilage that is lost early in the development of osteoarthritis (OA). Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic. The purpose of this review is to outline the current status of dGEMRIC in the assessment of hip joint cartilage. A literature search was performed with PubMed, using the terms ''cartilage, osteoarthritis, hip joint, MRI, and dGEMRIC'', considering all levels of studies. This review revealed that dGEMRIC can be reliably used in the evaluation of early stage cartilage pathology in various hip joint disorders. Modifications in the technique, such as the operation of three-dimensional imaging and dGEMRIC after intra-articular contrast medium administration, have expanded the range of application. Notably, the studies differ considerably in patient selection and technical prerequisites. Furthermore, there is a need for multicenter prospective studies with the required technical conditions in place to establish outcome based dGEMRIC data to obtain, in conjunction with clinical data, reliable threshold values for normal and abnormal cartilage, and for hips that may benefit from conservative or surgical treatment. (orig.)

  11. Osseointegration of titanium, titanium alloy and zirconia dental implants: current knowledge and open questions.

    Science.gov (United States)

    Bosshardt, Dieter D; Chappuis, Vivianne; Buser, Daniel

    2017-02-01

    Bone healing around dental implants follows the pattern and sequence of intramembraneous osteogenesis with formation of woven bone first of all followed later by formation of parallel-fibered and lamellar bone. Bone apposition onto the implant surface starts earlier in trabecular bone than in compact bone. While the first new bone may be found on the implant surface around 1 week after installation, bone remodeling starts at between 6 and 12 weeks and continues throughout life. Bone remodeling also involves the bone-implant interface, thus transiently exposing portions of the implant surface. Surface modifications creating micro-rough implant surfaces accelerate the osseointegration process of titanium implants, as demonstrated in numerous animal experiments. Sandblasting followed by acid-etching may currently be regarded as the gold standard technique to create micro-rough surfaces. Chemical surface modifications, resulting in higher hydrophilicity, further increase the speed of osseointegration of titanium and titanium-zirconium implants in both animals and humans. Surface modifications of zirconia and alumina-toughened zirconia implants also have an influence on the speed of osseointegration, and some implant types reach high bone-to-implant contact values in animals. Although often discussed independently of each other, surface characteristics, such as topography and chemistry, are virtually inseparable. Contemporary, well-documented implant systems with micro-rough implant surfaces, placed by properly trained and experienced clinicians, demonstrate high long-term survival rates. Nevertheless, implant failures do occur. A low percentage of implants are diagnosed with peri-implantitis after 10 years in function. In addition, a low number of implants seem to be lost for primarily reasons other than biofilm-induced infection. Patient factors, such as medications interfering with the immune system and bone cells, may be an element contributing to continuous bone

  12. Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases

    International Nuclear Information System (INIS)

    Zilkens, Christoph; Krauspe, Ruediger; Bittersohl, Bernd; Tiderius, Carl Johann

    2015-01-01

    Accurate assessment of early hip joint cartilage alterations may help optimize patient selection and follow-up of hip joint preservation surgery. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is sensitive to the glycosaminoglycan content in cartilage that is lost early in the development of osteoarthritis (OA). Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic. The purpose of this review is to outline the current status of dGEMRIC in the assessment of hip joint cartilage. A literature search was performed with PubMed, using the terms ''cartilage, osteoarthritis, hip joint, MRI, and dGEMRIC'', considering all levels of studies. This review revealed that dGEMRIC can be reliably used in the evaluation of early stage cartilage pathology in various hip joint disorders. Modifications in the technique, such as the operation of three-dimensional imaging and dGEMRIC after intra-articular contrast medium administration, have expanded the range of application. Notably, the studies differ considerably in patient selection and technical prerequisites. Furthermore, there is a need for multicenter prospective studies with the required technical conditions in place to establish outcome based dGEMRIC data to obtain, in conjunction with clinical data, reliable threshold values for normal and abnormal cartilage, and for hips that may benefit from conservative or surgical treatment. (orig.)

  13. Integrating Multiple On-line Knowledge Bases for Disease-Lab Test Relation Extraction.

    Science.gov (United States)

    Zhang, Yaoyun; Soysal, Ergin; Moon, Sungrim; Wang, Jingqi; Tao, Cui; Xu, Hua

    2015-01-01

    A computable knowledge base containing relations between diseases and lab tests would be a great resource for many biomedical informatics applications. This paper describes our initial step towards establishing a comprehensive knowledge base of disease and lab tests relations utilizing three public on-line resources. LabTestsOnline, MedlinePlus and Wikipedia are integrated to create a freely available, computable disease-lab test knowledgebase. Disease and lab test concepts are identified using MetaMap and relations between diseases and lab tests are determined based on source-specific rules. Experimental results demonstrate a high precision for relation extraction, with Wikipedia achieving the highest precision of 87%. Combining the three sources reached a recall of 51.40%, when compared with a subset of disease-lab test relations extracted from a reference book. Moreover, we found additional disease-lab test relations from on-line resources, indicating they are complementary to existing reference books for building a comprehensive disease and lab test relation knowledge base.

  14. Knowledge, Attitudes, and Practices Related to Preoperative Chemoradiotherapy in Rectal Cancer Patients

    Directory of Open Access Journals (Sweden)

    Xingxing Chen

    2016-01-01

    Full Text Available Background. The aim of this study is to assess the knowledge, attitudes, and practices related to pre-CRT in patients of stage II/III rectal cancer. Materials and Methods. Questionnaires regarding the knowledge, attitudes, and practices of pre-CRT were mailed to 145 rectal cancer patients in II/III stage between January 2012 and December 2014, and 111 agreed to participate and returned completed questionnaires to the researcher. Logistic regression model was used to compare sociodemographic characteristics, knowledge, and attitude with practice, respectively. Results. A total of 145 patients were approached for interview, of which 111 responded and 48.6% (54 had undergone pre-CRT. Only 31.5% of the participants knew that CRT is a treatment of rectal cancer and 39.6% were aware of the importance of CRT. However, the vast majority of participants (68.5% expressed a positive attitude toward rectal cancer. Multivariate logistic regression analysis revealed that knowledge level (p=0.006 and attitudes (p=0.001 influence the actual practice significantly. Furthermore, age, gender, and income were potential predictors of practice (all p<0.05. Conclusion. This study shows that, despite the fact that participants had suboptimal level of knowledge on rectal cancer, their attitude is favorable to pre-CRT. Strengthening the professional health knowledge and realizing the importance of attitudes may deepen patients’ understanding of preoperative therapy.

  15. Moblogging Type and Its Relation with Usability and Development of Knowledge Management Skills for Blind Students

    Science.gov (United States)

    Mostafa, Akram Fathy

    2015-01-01

    The aim of the research is to explore the relation of mobile Blogging (Moblogging -MB) on the usability and development of Knowledge Management skills for Blind Students. The research followed a pretest and posttest quasi experimental design. Participants were 17 blind students from the third semester of the academic year 2015 in the course of…

  16. Causal relations between knowledge-intensive business services and regional employment growth

    NARCIS (Netherlands)

    Brenner, T.; Capasso, M.; Duschl, M.; Frenken, K.; Treibich, T.G.

    2015-01-01

    This paper studies the causal relations between regional employment growth in Knowledge-Intensive Business Services (KIBS) and overall regional employment growth using German labour-market data for the period 1999-2012. Adopting a recently developed technique, we are able to estimate a structural

  17. Examining the Relative Contributions of Content Knowledge and Strategic Processing to Comprehension

    Science.gov (United States)

    Aukerman, Maren; Brown, Rachel; Mokhtari, Kouider; Valencia, Sheila; Palincsar, Annemarie

    2015-01-01

    The essays below were prepared following the LRA session organized by Janice Almasi entitled, "Examining the relative contributions of content knowledge and strategic processing to comprehension." What unites these essays are the personal and historical stances that each writer has taken; in addition, the essays are rich with…

  18. Risk perception: The social construction of spatial knowledge around climate change-related scenarios in Lima

    NARCIS (Netherlands)

    Miranda Sara, L.; Jameson, S.; Pfeffer, K.; Baud, I.

    2016-01-01

    Lima's environmental sustainability is threatened by increasing water scarcity, heavy rain events and limited attention for water vulnerability and climate change scenarios. In this paper we examine how knowledge construction and risk perception on water-related disaster risks and vulnerabilities

  19. Family Child Care Learning Environments: Caregiver Knowledge and Practices Related to Early Literacy and Mathematics

    Science.gov (United States)

    Phillips, Beth M.; Morse, Erika E.

    2011-01-01

    This paper presents findings from a stratified-random survey of family child care providers' backgrounds, caregiving environments, practices, attitudes, and knowledge related to language, literacy, and mathematics development for preschool children. Descriptive results are consistent with prior studies suggesting that home-based providers are…

  20. "Approaching the Sacred": Directionality in the Relation between Curriculum and Knowledge Structure

    Science.gov (United States)

    Gamble, Jeanne

    2014-01-01

    Increasing pressure on all levels of educational provision, whether academic or overtly vocational, to be to "relevant" and "useful" prompts consideration of the relation between curriculum and pedagogy in terms of the internal structure of knowledge forms. Following Durkheim's distinction between "sacred" and…

  1. Importance of Health-Related Fitness Knowledge to Increasing Physical Activity and Physical Fitness

    Science.gov (United States)

    Ferkel, Rick C.; Judge, Lawrence W.; Stodden, David F.; Griffin, Kent

    2014-01-01

    Physical inactivity is expanding across all ages in the United States. Research has documented a deficiency in health-related fitness knowledge (HRFK) among elementary- through college-aged students. The need for a credible and reliable resource that provides research-based information regarding the importance of HRFK is significant. The purpose…

  2. The neuroendocrine regulation of food intake in fish: a review of current knowledge

    Directory of Open Access Journals (Sweden)

    Helene Volkoff

    2016-11-01

    Full Text Available Fish are the most diversified group of vertebrates and, although progress has been made in the past years, only relatively few fish species have been examined to date, with regards to the endocrine regulation of feeding in fish. In fish, as in mammals, feeding behavior is ultimately regulated by central effectors within feeding centers of the brain, which receive and process information from endocrine signals from both brain and peripheral tissues. Although basic endocrine mechanisms regulating feeding appear to be conserved among vertebrates, major physiological differences between fish and mammals and the diversity of fish, in particular in regard to feeding habits, digestive tract anatomy and physiology, suggest the existence of fish- and species-specific regulating mechanisms. This review provides an overview of hormones known to regulate food intake in fish, emphasizing on major hormones and the main fish groups studied to date.

  3. Stress and breast cancer: a systematic update on the current knowledge

    DEFF Research Database (Denmark)

    Nielsen, Naja Rod; Grønbaek, Morten

    2006-01-01

    A vast body of research has been carried out to examine the relationship between psychological stress and the risk of breast cancer. Previous reviews on this issue have mainly focused on stressful life events and have included both prospective and retrospective studies. The results from...... these reviews have revealed conflicting data. We evaluate whether stressful life events, work-related stress, or perceived global stress are differentially associated with breast cancer incidence and breast cancer relapse in prospective studies. Systematic and explicit methods were used to identify, select......, and critically appraise relevant studies. The substantial variability in the manner in which stress was conceptualized and measured did not allow for the calculation of a quantitative summary estimate for the association between stress and breast cancer. Despite the heterogeneity in the results obtained...

  4. Thiomersal-containing vaccines - a review of the current state of knowledge.

    Science.gov (United States)

    Gołoś, Aleksandra; Lutyńska, Anna

    2015-01-01

    Thiomersal is an organomercury compound known for its antiseptic and antifungal properties and used as an antibacterial agent in pharmaceutical products, including vaccines and other injectable biological products. In recent years, concerns about the possible link between immunization with thiomersal-containing vaccines and autism development have grown. Many case-control and cohort studies have been conducted on a number of populations, and none of them have confirmed the hypothetical relation between thiomersal and increased risk of autism spectrum disorders (ASDs) development. It is also confirmed by the fact, that since 1999, number of thiomersal-containing vaccines used worldwide is decreasing year by year, while the prevalence of ASDs cases is rising. There are no contraindications to the use of vaccines with thiomersal in infants, children and non-pregnant women. The risk of serious complications associated with the development of diseases in unvaccinated individuals far outweighs the potential risk of adverse consequences associated with immunization with thiomersal-containing vaccines.

  5. Occupational cancer risk in pilots and flight attendants: current epidemiological knowledge

    International Nuclear Information System (INIS)

    Blettner, M.; Zeeb, H.; Grosche, B.

    1998-01-01

    Occupational studies of aircrew in civil or military aviation did not receive much attention until the beginning of this decade. Since 1990, a number of epidemiological studies has been published on the cancer risk among flight personnel. Their results are equivocal: elevated cancer risks have been observed in some studies, but not in others. The exposure situation for pilots and flight attendants is unique with respect to several factors and particularly in that cosmic rays contribute substantially to their cumulative radiation dose. The average annual doses received are relatively low, however, and commonly range between 3 and 6 mSv. Results of epidemiological studies are presented as well as information on planned studies. (orig.)

  6. Current studies related to the use of burnup credit in France

    International Nuclear Information System (INIS)

    Raby, Jerome; Lavarenne, Caroline; Barreau, Anne; Riffard, Cecile; Roque, Benedicte; Bioux, Philippe; Doucet, Michel; Guillou, Eric; Leka, Georges; Toubon, Herve

    2003-01-01

    In order to avoid criticality risks, a large number of facilities using spent fuels have been designed considering the fuel as fresh. This choice has obviously led to considerable safety margins. In the early 80's, a method was accepted by the French Safety Authorities allowing to consider the changes in the fuel composition during the depletion with some very pessimistic hypothesis: only actinides were considered and the amount of burnup used in the studies was equal to the mean burnup in the 50-least-irradiated centimeters. As many facilities still want to optimize their processes (e.g. transportation, storage, fuel reprocessing), the main companies involved in the French nuclear industry, researchers and IRSN set up a Working Group in order to study the way burnup could be taken into account in the criticality calculations, considering some fission products and a more realistic axial profile of burnup. The first of this article introduces the current French method used to take burnup into account in the criticality studies. The second part is devoted to the studies achieved by the Working Group to improve this method, especially concerning the consideration of the neutron absorption of some fission products and of an axial profile of burnup: for that purpose, some results are presented related to the steps of the process like the depletion calculations, the definition of an axial profile and the criticality calculation. In the third part, some results (keff) obtained with fission products and an axial profile are compared to those obtained with the current one. The conclusions presented are related to the present state of knowledge and may differ from the final conclusions of the Working Group. (author)

  7. Toxoplasmosis seroprevalence in relation to knowledge and practice among pregnant women in Dhahran, Saudi Arabia.

    Science.gov (United States)

    Elsafi, Salah H; Al-Mutairi, Wasaef F; Al-Jubran, Khalid M; Abu Hassan, Mohamed M; Al Zahrani, Eidan M

    2015-01-01

    The epidemiological importance of the different routes of Toxoplasma gondii transmission is not known and depends largely on population behaviour and knowledge. This study was conducted to assess toxoplasmosis seropositivity and the related knowledge and preventive practices that are necessary for the prevention of the disease among pregnant women. All pregnant women attending antenatal clinic were tested for T. gondii immunoglobulins followed by a survey questionnaire that tested their knowledge and preventive practice. Statistical comparisons were made between the seropositive and negative ones. We determined a low to moderate seroprevalence of toxoplasmosis among pregnant women in Dhahran, Saudi Arabia as compared to many other parts of the world. The overall positivity rates of IgG and IgM against T. gondii among 400 pregnant women were 28.5 and 3%, respectively. 75.5% of the participants had never heard about toxoplasmosis and the associated risk factors. Lack of knowledge was associated with the higher risk of infection (OR = 4.04, p restaurants was reported for the first time to be related to a higher risk of infection (OR = 2.69, p < 0.001). Several possible risk factors were suggested through odds ratios calculation and overall knowledge of toxoplasmosis by pregnant women was poor. It is therefore vital to provide a formal education about toxoplasmosis risk factors to women of childbearing age.

  8. The importance of team level tacit knowledge and related characteristics of high-performing health care teams.

    Science.gov (United States)

    Friedman, Leonard H; Bernell, Stephanie L

    2006-01-01

    Team level tacit knowledge is related to the collective knowledge of the team members. It is the shared experience that results in the ability to successfully anticipate the reactions of teammates in typical and nontypical situations. This study evaluates how tacit knowledge and related team characteristics influence the performance of cardiothoracic surgery teams.

  9. A review of current knowledge on the effects of hydrogen on the pressure tubes of Ontario Hydro operating reactors

    International Nuclear Information System (INIS)

    Leger, M.

    1982-01-01

    Since the occurrence of cracking in Zr-2.5 wt% Nb pressure tubes in Pickering 'A' units 3 and 4 in 1974/75 a great deal of information on the behaviour of hydrogen in pressure tube materials has been generated through research effort by both AECL and Ontario Hydro. In order to use this information effectively and to provide direction and co-ordination for ongoing research, a review of available information and current concerns on hydrogen in pressure tubes was undertaken. The review was divided into two main areas of interest: hydrogen ingress and hydride effects. The uncertainties in the rates of hydrogen ingress into the pressure tubes have been found to be very large. On the basis of current knowledge, predictions of the future behaviour of pressure tubes due to hydride effects are extremely difficult

  10. Hydrothermal and Chemosynthetic Ecosystems in the Southern Ocean: Current Knowledge on their Biology Paper 217790

    Science.gov (United States)

    Linse, K.; Rogers, A. D.; Bohrmann, G.; Copley, J.; Tyler, P. A.

    2017-12-01

    The existence of hydrothermal and other chemosynthetic ecosystems is not surprising in the Antarctic, with its active volcanoes, mid-ocean ridges and back-arc basins, and abundance of marine mammals. In the last two decades a variety of active chemosynthetic ecosystems have been discovered in the Southern Ocean, including low- and high-temperature hydrothermal vents, methane seeps, and whalefalls. Here a summary of the data from the known chemosynthetic communites will be presented, comparing the faunas of vent sites in the Bransfield Strait with those of the East Scotia Ridge (ESR) and the South Sandwich Arc, assessing the fauna at the South Georgia methane seep sites, and discussing the fauna on Antarctic whale falls. As the faunal assemblages of the ESR vents are the most studied in detail to date, this talk therefore focusses on the diversity and composition of the ESR macrofaunal assemblages, their foodweb structure and microdistributions in relation to fluid chemistry and microbiology, and their phylogenetic and biogeographic relationships. The Southern Ocean drives the global ocean conveyor belt, and is suggested to be the centre of origin for global deep-sea fauna, as well as a region of high deep-sea species diversity. In the context of chemosynthetic environments, it may provide a gateway connecting the global vent and seep systems. The mostly endemic species of Southern Ocean vent macrofauna show links to either one or more oceans (Atlantic, Indian, and Pacific), with some evidence for circum-Antarctic connection. The ESR species Gigantopelta chessoia, Kiwa tyleri and Vulcanolepas scotiaensis have their closest known relatives at the Longqi Vent Field on the Southwest Indian Ridge (SWIR), and one species of polynoid polychaete is known from ESR and SWIR vents. Meanwhile, Lepetdrilus sp. and a vesiocomyid clam are linked with species in the Atlantic vent fields. The stichasterid Paulasterias tyleri, the polychaete Rarricirrus jennae and the anthozoan

  11. Knowledge levels of pre-school teachers related with basic first-aid practices, Isparta sample.

    Science.gov (United States)

    Sönmez, Yonca; Uskun, Ersin; Pehlivan, Azize

    2014-09-01

    The aim of this study was to evaluate the levels of knowledge of pre-school teachers working in the province center of Isparta related with basic first-aid practices and some factors which affected these levels of knowledge. In this cross-sectional, analytic study, 110 pre-school teachers working in the province center of Isparta constituted the population. A questionnaire questioning sociodemographic properties and the level of knowledge related with first-aid practices was applied under supervision. The level of knowledge was evaluated on a 20-point scale. In the analyses, Kruskal-Wallis and Mann-Whitney U tests and Spearman's rank correlation were used. The study was approved by the Ethical Committee for Clinical Studies of Süleyman Demirel University School of Medicine (registration number: 105). The mean score of first-aid knowledge of the pre-school teachers was found to be 11.9±2.9. The least known issues included washing the wound by soap and water after a dog bite, information related with the necessity of immobilization of a child who has fallen from a high level and the phone number of National Poison Information Center (16.4%, 20.9% and 22.7%, respectively). The scores of the subjects whose knowledge of first-aid was evaluated to be well were higher compared to the subjects whose knowledge of first-aid was evaluated to be moderate (p=0.009) and poor (p=0.001). It was found that first-aid scores did not show significant difference in terms of age, working period, having received first-aid training and having faced with a condition requiring first-aid previously (p>0.05, for all comparisons). It was found that pre-school teachers had insufficient first-aid knowledge. Since the first-aid knowledge scores of the subjects who reported that they received first-aid training before did not show significant difference, it was thought that the quality of training was as important as receiving training.

  12. [Atypical epithelial hyperplasia of the breast: current state of knowledge and clinical practice].

    Science.gov (United States)

    Lavoué, V; Bertel, C; Tas, P; Bendavid, C; Rouquette, S; Foucher, F; Audrain, O; Bouriel, C; Levêque, J

    2010-02-01

    The diagnosis of atypical epithelial hyperplasia (AEH) increases with breast cancer screening. AEH is divided in three groups: atypical ductal hyperplasia, columnar cell lesions with atypia, lobular neoplasia. The management of women with AEH is not consensual because of uncertainty about their diagnosis related to the type of the biopsy sampling (core needle biopsy or surgical excision) and their controversial clinical signification between risk marker and true precursor of breast cancer. A systematic review of published studies was performed. Medline baseline interrogation was performed with the following keywords: atypical ductal hyperplasia, columnar cell lesions with atypia, lobular neoplasia, core needle biopsy, breast cancer, precursor lesion, hormonal replacement therapy. For each breast lesion, identified publications (English or French) were assessed for clinical practise in epidemiology, diagnosis and patient management. With immunohistochemistry and molecular studies, AEH seems to be precursor of breast cancer. But, epidemiological studies show low rate of breast cancer in women with AEH. AEH were still classified as risk factor of breast cancer. Because of high rate of breast cancer underestimation, surgical excision is necessary after the diagnosis of AEH at core needle biopsy. Surgical oncology rules and collaboration with radiologist are required for this surgery. A second operation was not required due to involved margins by AEH (except with pleiomorphic lobular neoplasia) because local control of breast cancer seems to be unchanged. Besides, hormonal replacement therapy for patient with AEH is not recommended because of lack of studies about this subject. Copyright 2009 Elsevier Masson SAS. All rights reserved.

  13. Review of the effects of protection in marine protected areas: current knowledge and gaps

    Directory of Open Access Journals (Sweden)

    Ojeda–Martínez, C.

    2011-06-01

    Full Text Available The effectiveness of marine protected areas (MPAs and the conservation of marine environments must be based on reliable information on the quality of the marine environment that can be obtained in a reasonable timeframe. We reviewed studies that evaluated all aspects related to the effectiveness of MPAs in order to describe how the studies were conducted and to detect fields in which research is lacking. Existing parameters used to evaluate the effectiveness of MPAs are summarised. Two-hundred and twenty-two publications were reviewed. We identified the most commonly used study subjects and methodological approaches. Most of the studies concentrated on biological parameters. Peer reviewed studies were based on control vs. impact design. BACI and mBACI designs were used in very few studies. Through this review, we have identified gaps in the objectives assigned to MPAs and the way in which they have been evaluated. We suggest some guidelines aimedat improving the assessment of the effects of protection in MPAs.

  14. Surgical templates for dental implant positioning; current knowledge and clinical perspectives

    Directory of Open Access Journals (Sweden)

    Mohammed Zaheer Kola

    2015-01-01

    Full Text Available Dental implants have been used in a variety of different forms for many years. Since the mid-20 th century, there has been an increase in interest in the implant process for the replacement of missing teeth. Branemark was one of the initial pioneers who applied scientifically based research techniques to develop an endosseous implant that forms an immobile connection with bone. The need for a dental implant to completely address multiple physical and biological factors imposes tremendous constraints on the surgical and handling protocol. Metallic dental implants have been successfully used for decades, but they have serious shortcomings related to their bony union and the fact that their mechanical properties do not match those of bone. However, anatomic limitation and restorative demands encourage the surgeon to gain precision in planning and surgical positioning of dental implants. Ideal placement of the implant facilitates the establishment of favorable forces on the implants and the prosthetic component as well as ensures an aesthetic outcome. Therefore, it is advisable to establish a logical continuity between the planned restoration and the surgical phases, it is essential to use a transfer device that for sure increases the predictability of success. The surgical guide template is fabricated by a dental technician after the presurgical restorative appointments that primarily include determination of occlusal scheme and implant angulations. Here, authors genuinely attempted to review the evolution and clinical applicability of surgical templates used in the placement of dental implants.

  15. Ecological economics of soil erosion: a review of the current state of knowledge.

    Science.gov (United States)

    Adhikari, Bhim; Nadella, Karthik

    2011-02-01

    The economics of land degradation has received relatively little attention until recent years. Although a number of studies have undertaken valuation of ecosystem services ranging from the global to the micro level, and quite a few studies have attempted to quantify the costs of soil erosion, studies that address the full costs of land degradation are still scarce. In this review, we attempt to analyze different land resource modeling and valuation techniques applied in earlier research and the type of data used in these analyses, and to assess their utility for different forms of land resource and management appraisal. We also report on the strengths and weaknesses of different valuation techniques used in studies on the economics of soil erosion, and the relevance of these valuation techniques. We make a case for the need for more appropriate models that can make the analysis more robust in estimating the economic costs of land degradation while recognizing the spatial heterogeneity in biophysical and economic conditions. © 2011 New York Academy of Sciences.

  16. Ecology of Zoonotic Infectious Diseases in Bats: Current Knowledge and Future Directions

    Science.gov (United States)

    Hayman, D T S; Bowen, R A; Cryan, P M; McCracken, G F; O’Shea, T J; Peel, A J; Gilbert, A; Webb, C T; Wood, J L N

    2013-01-01

    Bats are hosts to a range of zoonotic and potentially zoonotic pathogens. Human activities that increase exposure to bats will likely increase the opportunity for infections to spill over in the future. Ecological drivers of pathogen spillover and emergence in novel hosts, including humans, involve a complex mixture of processes, and understanding these complexities may aid in predicting spillover. In particular, only once the pathogen and host ecologies are known can the impacts of anthropogenic changes be fully appreciated. Cross-disciplinary approaches are required to understand how host and pathogen ecology interact. Bats differ from other sylvatic disease reservoirs because of their unique and diverse lifestyles, including their ability to fly, often highly gregarious social structures, long lifespans and low fecundity rates. We highlight how these traits may affect infection dynamics and how both host and pathogen traits may interact to affect infection dynamics. We identify key questions relating to the ecology of infectious diseases in bats and propose that a combination of field and laboratory studies are needed to create data-driven mechanistic models to elucidate those aspects of bat ecology that are most critical to the dynamics of emerging bat viruses. If commonalities can be found, then predicting the dynamics of newly emerging diseases may be possible. This modelling approach will be particularly important in scenarios when population surveillance data are unavailable and when it is unclear which aspects of host ecology are driving infection dynamics. PMID:22958281

  17. Sepsis in Internal Medicine wards: current knowledge, uncertainties and new approaches for management optimization.

    Science.gov (United States)

    Zaccone, Vincenzo; Tosoni, Alberto; Passaro, Giovanna; Vallone, Carla Vincenza; Impagnatiello, Michele; Li Puma, Domenica Donatella; De Cosmo, Salvatore; Landolfi, Raffaele; Mirijello, Antonio

    2017-11-01

    Sepsis represents a global health problem in terms of morbidity, mortality, social and economic costs. Although usually managed in Intensive Care Units, sepsis showed an increased prevalence among Internal Medicine wards in the last decade. This is substantially due to the ageing of population and to multi-morbidity. These characteristics represent both a risk factor for sepsis and a relative contra-indication for the admission to Intensive Care Units. Although there is a lack of literature on the management of sepsis in Internal Medicine, the outcome of these patients seems to be gradually improving. This is due to Internists' increased adherence to guidelines and "bundles". The routine use of SOFA score helps physicians in the definition of septic patients, even if the optimal score has still to come. Point-of-care ultrasonography, lactates, procalcitonin and beta-d-glucan are of help for treatment optimization. The purpose of this narrative review is to focus on the management of sepsis in Internal Medicine departments, particularly on crucial concepts regarding diagnosis, risk assessment and treatment. Key Messages Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The prevalence of sepsis is constantly increasing, affecting more hospital patients than any other disease. At least half of patients affected by sepsis are admitted to Internal Medicine wards. Adherence to guidelines, routine use of clinical and lab scores and point-of-care ultrasonography are of help for early recognition of septic patients and treatment optimization.

  18. Ecology of zoonotic infectious diseases in bats: current knowledge and future directions

    Science.gov (United States)

    Hayman, D.T.; Bowen, R.A.; Cryan, P.M.; McCracken, G.F.; O'Shea, T.J.; Peel, A.J.; Gilbert, A.; Webb, C.T.; Wood, J.L.

    2013-01-01

    Bats are hosts to a range of zoonotic and potentially zoonotic pathogens. Human activities that increase exposure to bats will likely increase the opportunity for infections to spill over in the future. Ecological drivers of pathogen spillover and emergence in novel hosts, including humans, involve a complex mixture of processes, and understanding these complexities may aid in predicting spillover. In particular, only once the pathogen and host ecologies are known can the impacts of anthropogenic changes be fully appreciated. Cross-disciplinary approaches are required to understand how host and pathogen ecology interact. Bats differ from other sylvatic disease reservoirs because of their unique and diverse lifestyles, including their ability to fly, often highly gregarious social structures, long lifespans and low fecundity rates. We highlight how these traits may affect infection dynamics and how both host and pathogen traits may interact to affect infection dynamics. We identify key questions relating to the ecology of infectious diseases in bats and propose that a combination of field and laboratory studies are needed to create data-driven mechanistic models to elucidate those aspects of bat ecology that are most critical to the dynamics of emerging bat viruses. If commonalities can be found, then predicting the dynamics of newly emerging diseases may be possible. This modelling approach will be particularly important in scenarios when population surveillance data are unavailable and when it is unclear which aspects of host ecology are driving infection dynamics.

  19. Poly(aspartic acid) (PAA) hydrolases and PAA biodegradation: current knowledge and impact on applications.

    Science.gov (United States)

    Hiraishi, Tomohiro

    2016-02-01

    Thermally synthesized poly(aspartic acid) (tPAA) is a bio-based, biocompatible, biodegradable, and water-soluble polymer that has a high proportion of β-Asp units and equivalent moles of D- and L-Asp units. Poly(aspartic acid) (PAA) hydrolase-1 and hydrolase-2 are tPAA biodegradation enzymes purified from Gram-negative bacteria. PAA hydrolase-1 selectively cleaves amide bonds between β-Asp units via an endo-type process, whereas PAA hydrolase-2 catalyzes the exo-type hydrolysis of the products of tPAA hydrolysis by PAA hydrolase-1. The novel reactivity of PAA hydrolase-1 makes it a good candidate for a biocatalyst in β-peptide synthesis. This mini-review gives an overview of PAA hydrolases with emphasis on their biochemical and functional properties, in particular, PAA hydrolase-1. Functionally related enzymes, such as poly(R-3-hydroxybutyrate) depolymerases and β-aminopeptidases, are compared to PAA hydrolases. This mini-review also provides findings that offer an insight into the catalytic mechanisms of PAA hydrolase-1 from Pedobacter sp. KP-2.

  20. Hydrologic studies within the Columbia Plateau, Washington: an integration of current knowledge

    International Nuclear Information System (INIS)

    Gephart, R.E.; Arnett, R.C.; Baca, R.G.; Leonhart, L.S.; Spane, F.A. Jr.

    1979-10-01

    Hydrologic studies are one of the principal research activities within the Basalt Waste Isolation Project. The objective of these studies is to provide a clear evaluation of the hydrologic systems present within the Columbia River basalt significant to the possible siting of a waste repository. This is accomplished through an intense data gathering program in addition to conducting groundwater flow and solute transport modeling under both anticipated and credible hypothetical hydrologic scenarios. The hydrology effort is centered within the Pasco Basin located in south-central Washington State, particularly that portion of the basin within the Hanford Site. Regional hydrology studies for other portions of the Columbia Plateau are being carried out to assist in understanding the surface-water and groundwater flow systems existing within the Pasco Basin. The major questions being addressed in all of the above studies focus upon important repository considerations related to groundwater flow paths, groundwater velocities, and solute concentrations and travel times. This report summarizes the data obtained and interpretations made to date regarding the hydrology of the Pasco Basin. The text of this report is divided into four chapters. Chapter I describes the purpose and scope of the hydrology program. Chapter II discusses the regional studies. Chapter III discusses the Pasco Basin hydrology, and Chapter IV gives a status report of the numerical modeling activities

  1. Assessment of knowledge, attitude, and practice related to epilepsy: a community-based study

    Directory of Open Access Journals (Sweden)

    Teferi J

    2015-05-01

    Full Text Available Jalle Teferi,1 Zewdu Shewangizaw2 1Addis Ababa Health Bureau, Zewuditu Specialized Hospital, Addis Ababa, Ethiopia; 2College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia Abstract: Religious and sociocultural beliefs influence the nature of treatment and care received by people with epilepsy. Many communities in Africa and other developing nations believe that epilepsy results from evil spirits, and thus, treatment should be through the use of herbaceous plants from traditional doctors and religious leadership. Community-based cross-sectional study designs were used to assess the knowledge, attitude, and practice related to epilepsy and its associated factors by using a pretested, semi-structured questionnaire among 660 respondents living in Sululta Woreda, Oromia, Ethiopia. According to the results of this study, 59.8% of the respondents possessed knowledge about epilepsy, 35.6% had a favorable attitude, and 33.5% of them adopted safe practices related to epilepsy. The following factors had significant association to knowledge, attitude, and practice related to epilepsy: being rural dwellers, living alone, those with more years of formal education, heard information about epilepsy, distance of health facility from the community, had witnessed an epileptic seizure, age range from 46 years to 55 years, had heard about epilepsy, prior knowledge of epilepsy, occupational history of being self-employed or a laborer, history of epilepsy, and history of epilepsy in family member. The findings indicated that the Sululta community is familiar with epilepsy, has an unfavorable attitude toward epilepsy, and unsafe practices related to epilepsy, but has a relatively promising knowledge of epilepsy. Keywords: Oromia, favorable attitude, safe practice, rural

  2. Black (pyrogenic carbon: a synthesis of current knowledge and uncertainties with special consideration of boreal regions

    Directory of Open Access Journals (Sweden)

    C. M. Preston

    2006-01-01

    Full Text Available The carbon (C cycle in boreal regions is strongly influenced by fire, which converts biomass and detrital C mainly to gaseous forms (CO2 and smaller proportions of CO and CH4, and some 1–3% of mass to pyrogenic C (PyC. PyC is mainly produced as solid charred residues, including visually-defined charcoal, and a black carbon (BC fraction chemically defined by its resistance to laboratory oxidation, plus much lower proportions of volatile soot and polycyclic aromatic hydrocarbons (PAHs. All PyC is characterized by fused aromatic rings, but varying in cluster sizes, and presence of other elements (N, O and functional groups. The range of PyC structures is often described as a continuum from partially charred plant materials, to charcoal, soot and ultimately graphite which is formed by the combination of heat and pressure. There are several reasons for current interest in defining more precisely the role of PyC in the C cycle of boreal regions. First, PyC is largely resistant to decomposition, and therefore contributes to very stable C pools in soils and sediments. Second, it influences soil processes, mainly through its sorption properties and cation exchange capacity, and third, soot aerosols absorb solar radiation and may contribute to global warming. However, there are large gaps in the basic information needed to address these topics. While charcoal is commonly defined by visual criteria, analytical methods for BC are mainly based on various measures of oxidation resistance, or on yield of benzenepolycarboxylic acids. These methods are still being developed, and capture different fractions of the PyC structural continuum. There are few quantitative reports of PyC production and stocks in boreal forests (essentially none for boreal peatlands, and results are difficult to compare due to varying experimental goals and methods, as well as inconsistent terminology. There are almost no direct field measurements of BC aerosol production from boreal

  3. Knowledge of stroke among stroke patients and their relatives in Northwest India.

    Science.gov (United States)

    Pandian, Jeyaraj Durai; Kalra, Guneet; Jaison, Ashish; Deepak, Sukhbinder Singh; Shamsher, Shivali; Singh, Yashpal; Abraham, George

    2006-06-01

    The knowledge of warning symptoms and risk factors for stroke has not been studied among patients with stroke in developing countries. We aimed to assess the knowledge of stroke among patients with stroke and their relatives. Prospective tertiary referral hospital-based study in Northwest India. Trained nurses and medical interns interviewed patients with stroke and transient ischemic attack and their relatives about their knowledge of stroke symptoms and risk factors. Univariable and multivariable logistic regression were used. Of the 147 subjects interviewed, 102 (69%) were patients and 45 (31%) were relatives. There were 99 (67%) men and 48 (33%) women and the mean age was 59.7+/-14.1 years. Sixty-two percent of respondents recognized paralysis of one side as a warning symptom and 54% recognized hypertension as a risk factor for stroke. In the multivariable logistic regression analysis, higher education was associated with the knowledge of correct organ involvement in stroke (OR 2.6, CI 1.1- 6.1, P =0.02), whereas younger age (OR 2.7, CI 1.1-7.0, P =0.04) and higher education (OR 4.1, CI 1.5-10.9, P =0.005) correlated with a better knowledge regarding warning symptoms of stroke. In this study cohort, in general, there is lack of awareness of major warning symptoms, risk factors, organ involvement and self-recognition of stroke. However younger age and education status were associated with better knowledge. There is an urgent need for awareness programs about stroke in this study cohort.

  4. Current knowledge and future research on infant feeding in the context of HIV: basic, clinical, behavioral, and programmatic perspectives.

    Science.gov (United States)

    Young, Sera L; Mbuya, Mduduzi N N; Chantry, Caroline J; Geubbels, Eveline P; Israel-Ballard, Kiersten; Cohan, Deborah; Vosti, Stephen A; Latham, Michael C

    2011-05-01

    In 2008, between 129,000 and 194,000 of the 430,000 pediatric HIV infections worldwide were attributable to breastfeeding. Yet in many settings, the health, economic, and social consequences of not breastfeeding would have dire consequences for many more children. In the first part of this review we provide an overview of current knowledge about infant feeding in the context of HIV. Namely, we describe the benefits and risks of breastmilk, the evolution of recommended infant feeding modalities in high-income and low-income countries in the last two decades, and contextualize the recently revised guidelines for infant feeding in the context of HIV current knowledge. In the second section, we suggest areas for future research on the postnatal prevention of mother-to-child transmission of HIV (PMTCT) in developing and industrialized countries. We suggest two shifts in perspective. The first is to evaluate PMTCT interventions more holistically, to include the psychosocial and economic consequences as well as the biomedical ones. The second shift in perspective should be one that contextualizes postnatal PMTCT efforts in the cascade of maternal health services. We conclude by discussing basic, clinical, behavioral, and programmatic research questions pertaining to a number of PMTCT efforts, including extended postnatal ARV prophylaxis, exclusive breastfeeding promotion, counseling, breast milk pasteurization, breast milk banking, novel techniques for making breast milk safer, and optimal breastfeeding practices. We believe the research efforts outlined here will maximize the number of healthy, thriving, HIV-free children around the world.

  5. Current Knowledge and Future Research on Infant Feeding in the Context of HIV: Basic, Clinical, Behavioral, and Programmatic Perspectives12

    Science.gov (United States)

    Young, Sera L.; Mbuya, Mduduzi N. N.; Chantry, Caroline J.; Geubbels, Eveline P.; Israel-Ballard, Kiersten; Cohan, Deborah; Vosti, Stephen A.; Latham, Michael C.

    2011-01-01

    In 2008, between 129,000 and 194,000 of the 430,000 pediatric HIV infections worldwide were attributable to breastfeeding. Yet in many settings, the health, economic, and social consequences of not breastfeeding would have dire consequences for many more children. In the first part of this review we provide an overview of current knowledge about infant feeding in the context of HIV. Namely, we describe the benefits and risks of breastmilk, the evolution of recommended infant feeding modalities in high-income and low-income countries in the last two decades, and contextualize the recently revised guidelines for infant feeding in the context of HIV current knowledge. In the second section, we suggest areas for future research on the postnatal prevention of mother-to-child transmission of HIV (PMTCT) in developing and industrialized countries. We suggest two shifts in perspective. The first is to evaluate PMTCT interventions more holistically, to include the psychosocial and economic consequences as well as the biomedical ones. The second shift in perspective should be one that contextualizes postnatal PMTCT efforts in the cascade of maternal health services. We conclude by discussing basic, clinical, behavioral, and programmatic research questions pertaining to a number of PMTCT efforts, including extended postnatal ARV prophylaxis, exclusive breastfeeding promotion, counseling, breast milk pasteurization, breast milk banking, novel techniques for making breast milk safer, and optimal breastfeeding practices. We believe the research efforts outlined here will maximize the number of healthy, thriving, HIV-free children around the world. PMID:22332055

  6. School-Based Educational Intervention to Improve Children's Oral Health-Related Knowledge.

    Science.gov (United States)

    Blake, Holly; Dawett, Bhupinder; Leighton, Paul; Rose-Brady, Laura; Deery, Chris

    2015-07-01

    To evaluate a brief oral health promotion intervention delivered in schools by a primary care dental practice, aimed at changing oral health care knowledge and oral health-related behaviors in children. Cohort study with pretest-posttest design. Three primary schools. One hundred and fifty children (aged 9-12 years). Children received a 60-minute theory-driven classroom-based interactive educational session delivered by a dental care professional and received take-home literature on oral health. All children completed a questionnaire on oral health-related knowledge and self-reported oral health-related behaviors before, immediately after, and 6 weeks following the intervention. Children's dental knowledge significantly improved following the intervention, with improvement evident at immediate follow-up and maintained 6 weeks later. Significantly more children reported using dental floss 6 weeks after the intervention compared with baseline. No significant differences were detected in toothbrushing or dietary behaviors. School-based preventative oral health education delivered by primary care dental practices can generate short-term improvements in children's knowledge of oral health and some aspects of oral hygiene behavior. Future research should engage parents/carers and include objective clinical and behavioral outcomes in controlled study designs. © 2014 Society for Public Health Education.

  7. Legal rights to safe abortion: knowledge and attitude of women in North-West Ethiopia toward the current Ethiopian abortion law.

    Science.gov (United States)

    Muzeyen, R; Ayichiluhm, M; Manyazewal, T

    2017-07-01

    To assess women's knowledge and attitude toward Ethiopian current abortion law. A quantitative, community-based cross-sectional survey. Women of reproductive age in three selected lower districts in Bahir Dar, North-West Ethiopia, were included. Multi-stage simple random sampling and simple random sampling were used to select the districts and respondents, respectively. Data were collected using a structured questionnaire comprising questions related to knowledge and attitude toward legal status of abortion and cases where abortion is currently allowed by law in Ethiopia. Descriptive statistics were used to summarize the data and multivariable logistic regression computed to assess the magnitude and significance of associations. Of 845 eligible women selected, 774 (92%) consented to participate and completed the interview. A total of 512 (66%) women were aware of the legal status of the Ethiopian abortion law and their primary sources of information were electronic media such as television and radio (43%) followed by healthcare providers (38.7%). Among women with awareness of the law, 293 (57.2%) were poor in knowledge, 188 (36.7%) fairly knowledgeable, and 31 (6.1%) good in knowledge about the cases where abortion is allowed by law. Of the total 774 women included, 438 (56.5%) hold liberal and 336 (43.5%) conservative attitude toward legalization of abortion. In the multivariable logistic regression, age had a significant association with knowledge, whereas occupation had a significant association with attitude toward the law. Women who had poor knowledge toward the law were more likely to have conservative attitude toward the law (adjusted odds ratio, 0.40; 95% confidence interval, 0.23-0.61). Though the Ethiopian criminal code legalized abortion under certain circumstances since 2005, a significant number of women knew little about the law and several protested legalization of abortion. Countries such as Ethiopia with high maternal mortality records need to lift

  8. Sex-related knowledge, attitudes, and behaviors of U.S. medical students.

    Science.gov (United States)

    Frank, Erica; Coughlin, Steven S; Elon, Lisa

    2008-08-01

    To understand the personal and clinical safe-sex-related knowledge, attitudes, and practices of U.S. medical students. Sixteen medical schools were selected to survey the class of 2003 based on their characteristics similar to the national average. Students were surveyed at freshman orientation, at entrance to wards, and during their senior year. The primary personal outcome was the response to the question, "Are you currently trying to practice safe sex when sexually involved? (no, not applicable/no, not trying/yes, low priority/yes, high priority)." The primary professional outcomes were answers to: 1) "How relevant do you think talking to patients about safe sex will be in your intended practice? (not at all/somewhat/highly)," and 2) "With a typical general medicine patient, how often do you actually talk about safe sex? (never-rarely/sometimes/usually-always)." A total of 2,316 students provided data, and the response rate was 80%. Personally practicing safe-sex habits was a high priority for 75% of the sexually active, single medical students, especially for women, African Americans, and those earlier in their medical education. Among seniors, 41% reported extensive training in discussing safe sex with patients, and 57% were highly confident about conducting such discussions. Overall, 55% of students believed it would be highly relevant to counsel patients about safe sex (59% of freshmen, 62% of those at entry to wards, and 41% of seniors); 73% answered all four true/false questions on human papillomavirus correctly. About half of U.S. medical students believed that counseling their patients about safe sex will not be highly relevant to their practice. These findings should be considered by those trying to interest a new generation of physicians in helping patients have safe-sex practices.

  9. Knowledge and attitudes of nurses towards alcohol and related problems: the impact of an educational intervention

    Directory of Open Access Journals (Sweden)

    Janaina Soares

    2013-10-01

    Full Text Available An exploratory study of quasi-experimental approach that aimed to verify the impact of an educational intervention on attitudes and knowledge of nurses towards alcohol use and associated problems. The sample included 185 nurses, divided into two groups: 84 submitted to a training course and formed the experimental group. Data were collected through a knowledge survey and an attitude scale. The attitudes of the participants of both groups were positive. There were no significant differences between groups in relation to knowledge. The strongest predictors of positive attitudes were possessed preparation to act with chemical dependents (OR = 2.18, "have received increased workload during graduation on the theme, 'alcohol and other drugs'" (OR = 1.70, and "completed graduate school" (OR = 2.59. The educational intervention had a positive impact on the attitudes of nurses towards alcoholics, work and interpersonal relationships with such clientele.

  10. Local ecological knowledge related with marine ecosystems in two coastal communities: El Valle and Sapzurro

    International Nuclear Information System (INIS)

    Correa, Sandra Liliana; Turbay, Sandra; Velez, Madelene

    2012-01-01

    The inhabitants of the Colombian coastal populations of El Valle, in the Pacific, and Sapzurro, in the Caribbean Darien, have ecological knowledge about coastal ecosystems that is a result of their constant relation with the sea, through fishing and navigation. The sea is a source of food and economical resources, but it is also the sphere where the male personality is forged. The accurate knowledge about mangrove, coral, coral reef, beaches and fishing grounds has been enriched through the dialog between local inhabitants and researchers in the conservation biology field. However, the tensions with researchers and environmental authorities still exist. The paper suggests that local ecological knowledge studies could be a starting point for maintaining a more horizontal dialogue between environmentalist and the populations with livelihoods derived of fishing.

  11. Metacognitive Knowledge in Relation to Inquiry Skills and Knowledge Acquisition Within a Computer-Supported Inquiry Learning Environment

    Directory of Open Access Journals (Sweden)

    Zrinka Ristić Dedić

    2014-04-01

    Full Text Available The study examines two components of metacognitive knowledge in the context of inquiry learning: metatask and metastrategic. Existing work on the topic has shown that adolescents often lacked metacognitive understanding necessary for optimal inquiry learning (Keselman & Kuhn, 2002; Kuhn, 2002a; Kuhn, Black, Keselman, & Kaplan, 2000, but demonstrated that engagement with inquiry tasks may improve it (Keselman, 2003; Kuhn & Pearsall, 1998.The aim of the study is to investigate the gains in metacognitive knowledge that occur as a result of repeated engagement with an inquiry learning task, and to examine the relationship between metacognitive knowledge and performance on the task.The participants were 34 eighth grade pupils, who participated in a self-directed experimentation task using the FILE programme (Hulshof, Wilhelm, Beishuizen, & van Rijn, 2005. The task required pupils to design and conduct experiments and to make inferences regarding the causal structure of a multivariable system. Pupils participated in four learning sessions over the course of one month. Metacognitive knowledge was assessed by the questionnaire before and after working in FILE.The results indicate that pupils improved in metacognitive knowledge following engagement with the task. However, many pupils showed insufficient metacognitive knowledge in the post-test and failed to apply newly achieved knowledge to the transfer task. Pupils who attained a higher level of metacognitive knowledge were more successful on the task than pupils who did not improve on metacognitive knowledge. A particular level of metacognitive understanding is a necessary, but not sufficient condition for successful performance on the task.

  12. Value Relativism and Perspective Taking are Two Distinct Facets of Wisdom-Related Knowledge.

    Science.gov (United States)

    Kunzmann, Ute; Nowak, Jana; Thomas, Stefanie; Nestler, Steffen

    2017-12-18

    There has been mixed evidence for age differences in wisdom-related knowledge across the adult life span. This study investigated two potential moderators of the link between age and wisdom-related knowledge: the wisdom criteria and the wisdom tasks. To test these moderators, 40 younger and 40 older participants completed four wisdom tasks differing in context-richness. Independent trained raters coded the resulting think-aloud protocols in terms of value relativism, as defined in the Berlin wisdom paradigm, and perspective taking, as defined by Grossmann. The type of task did not show any main or interaction effects on the present two wisdom criteria. However, age differences in the two wisdom criteria were multidirectional: whereas perspective taking did not differ by age group, value relativism was lower in older than younger adults. In addition, value relativism, but not perspective taking, was related to measures of fluid and crystallized intelligence, whereas perspective taking, but not value relativism, was related to a measure of life investment. This study provides evidence for the idea that value relativism and perspective taking are two distinct facets of wisdom-related knowledge. Implications for future age-comparative research interested in wisdom are discussed. © The Author(s) 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. Alcohol-Related Knowledge and Alcohol-Related Norms in 4- to 6-Year-Olds-Evidence from the Dutch Electronic Appropriate Beverage Task

    NARCIS (Netherlands)

    Voogt, Carmen; Otten, Roy; Kleinjan, Marloes; Engels, Rutger; Kuntsche, Emmanuel

    BACKGROUND: Limited research is available on children's alcohol-related knowledge and alcohol-related norms, yet a better comprehension of these factors may be crucial in explaining alcohol use later in life. This study provides insights into alcohol-related knowledge and alcohol-related norms in 4-

  14. Alcohol-related knowledge and alcohol-related norms in 4- to 6-year-olds: Evidence from the Dutch electronic Appropriate Beverage Task

    NARCIS (Netherlands)

    Voogt, C.V.; Otten, R.; Kleinjan, M.; Engels, R.C.M.E.; Kuntsche, E.N.

    2017-01-01

    Background: Limited research is available on children's alcohol-related knowledge and alcohol-related norms, yet a better comprehension of these factors may be crucial in explaining alcohol use later in life. This study provides insights into alcohol-related knowledge and alcohol-related norms in

  15. Building on prior knowledge: schema-dependent encoding processes relate to academic performance.

    Science.gov (United States)

    van Kesteren, Marlieke T R; Rijpkema, Mark; Ruiter, Dirk J; Morris, Richard G M; Fernández, Guillén

    2014-10-01

    The acquisition and retention of conceptual knowledge is more effective in well-structured curricula that provide an optimal conceptual framework for learning new material. However, the neural mechanisms by which preexisting conceptual schemas facilitate learning are not yet well understood despite their fundamental importance. A preexisting schema has been shown to enhance memory by influencing the balance between activity within the medial-temporal lobe and the medial pFC during mnemonic processes such as encoding, consolidation, and retrieval. Specifically, correctly encoding and retrieving information that is related to preexisting schemas appears rather related to medial prefrontal processing, whereas information unrelated or inconsistent with preexisting schemas rather relates to enhanced medial temporal processing and enhanced interaction between these structures. To further investigate interactions between these regions during conceptual encoding in a real-world university setting, we probed human brain activity and connectivity using fMRI during educationally relevant conceptual encoding carefully embedded within two course programs. Early second-year undergraduate biology and education students were scanned while encoding new facts that were either related or unrelated to the preexisting conceptual knowledge they had acquired during their first year of study. Subsequently, they were tested on their knowledge of these facts 24 hr later. Memory scores were better for course-related information, and this enhancement was associated with larger medial-prefrontal, but smaller medial-temporal subsequent memory effects. These activity differences went along with decreased functional interactions between these regions. Furthermore, schema-related medial-prefrontal subsequent memory effects measured during this experiment were found to be predictive of second-year course performance. These results, obtained in a real-world university setting, reveal brain

  16. Knowledge, Attitudes, and Practices Related to Preoperative Chemoradiotherapy in Rectal Cancer Patients.

    Science.gov (United States)

    Chen, Xingxing; Lin, Ruifang; Li, Huifang; Su, Meng; Zhang, Wenyi; Deng, Xia; Zhang, Ping; Zou, Changlin

    2016-01-01

    Background . The aim of this study is to assess the knowledge, attitudes, and practices related to pre-CRT in patients of stage II/III rectal cancer. Materials and Methods . Questionnaires regarding the knowledge, attitudes, and practices of pre-CRT were mailed to 145 rectal cancer patients in II/III stage between January 2012 and December 2014, and 111 agreed to participate and returned completed questionnaires to the researcher. Logistic regression model was used to compare sociodemographic characteristics, knowledge, and attitude with practice, respectively. Results . A total of 145 patients were approached for interview, of which 111 responded and 48.6% (54) had undergone pre-CRT. Only 31.5% of the participants knew that CRT is a treatment of rectal cancer and 39.6% were aware of the importance of CRT. However, the vast majority of participants (68.5%) expressed a positive attitude toward rectal cancer. Multivariate logistic regression analysis revealed that knowledge level ( p = 0.006) and attitudes ( p = 0.001) influence the actual practice significantly. Furthermore, age, gender, and income were potential predictors of practice (all p pre-CRT. Strengthening the professional health knowledge and realizing the importance of attitudes may deepen patients' understanding of preoperative therapy.

  17. Secondhand Smoke Exposure, Indoor Smoking Bans and Smoking-Related Knowledge in China

    Directory of Open Access Journals (Sweden)

    Yue Jin

    2014-12-01

    Full Text Available Although previous studies have provided strong evidence that Chinese individuals are exposed to secondhand smoke (SHS and lack knowledge of its harmful effects, there has not been an in-depth exploration of the variability in exposure and knowledge by geographic region, occupation, and socioeconomic status. The objectives of this study were to examine: (1 the demographic factors associated with the level of knowledge of the harmful effects of smoking; (2 the factors related to implementation of in-home and workplace smoking bans; and (3 geographic differences in being exposed to SHS in government buildings, healthcare facilities, restaurants, public transportations, and schools. We used data from the 2010 Global Adult Tobacco Survey-China. Chi-square tests were used for statistical analysis. The results suggested that among Chinese citizens age 15 years and older, there is poor knowledge of the harmful effects of tobacco, and knowledge varies with region and socioeconomic status. Over three-quarters of the households had no smoking restrictions, and a large percentage of workers reported working in places with no smoking ban. In public places, exposure to SHS was high, particularly in rural areas and in the Southwest. These results suggest Chinese individuals are not well informed of smoking and SHS associated risks and are regularly exposed to SHS at home, work and public places.

  18. Skier and Snowboarder Motivations and Knowledge Related to Voluntary Environmental Programs at an Alpine Ski Area

    Science.gov (United States)

    Little, Christopher M.; Needham, Mark D.

    2011-11-01

    Many alpine ski areas have recently adopted voluntary environmental programs (VEPs) such as using recycling, renewable energy, and biofuels to help reduce their environmental impacts. Studies have addressed the performance of these VEPs in mitigating environmental impacts of this industry, but little is known about visitor awareness and perceptions of these programs. This article addresses this knowledge gap by exploring skier and snowboarder knowledge of VEPs at a ski area and the influence of these programs on their motivations to visit this area currently and behavioral intentions to visit again in the future. Data were obtained from an onsite survey at the Mt. Bachelor ski area in Oregon, USA ( n = 429, 89.7% response rate). Few skiers and snowboarders were knowledgeable of VEPs at this area and fewer than 20% were motivated to visit on their current trip because of these programs. Other attributes such as scenery, snow conditions, and access were more important for influencing visitation. Up to 38% of skiers and snowboarders, however, intend to visit this ski area more often if it adopts and promotes more VEPs. Managers can use these results to inform communication and marketing of their environmental programs and performance to visitors. Additional implications for management and future research are discussed.

  19. Mining-Related Selenium Contamination in Alaska, and the State of Current Knowledge

    Directory of Open Access Journals (Sweden)

    Aibyek Khamkhash

    2017-03-01

    Full Text Available Selenium pollution has been a topic of extensive research dating back further than the last decade and has attracted significant attention from several environmental and regulatory agencies in order to monitor and control its discharge from myriad industrial sources. The mining industry is a prime contributor of hazardous selenium release in the aquatic systems and is responsible for both acute and chronic impacts on living organisms. Herein we provide an overview of selenium contamination issues, with a specific focus on selenium release from mining industries, including a discussion of various technologies commonly employed to treat selenium-impacted waters from mining discharge. Different cases pertaining to selenium release from Alaskan mines (during years 2000–2015 are also presented, along with measures taken to mitigate high concentration releases. For continued resource exploration and economic development activities, as well as environmental preservation, it is important to fundamentally understand such emerging and pressing issues as selenium contamination and investigate efficient technological approaches to counter these challenges.

  20. Unsupervised knowledge structuring Application of Infinite Relational Models to the FCA visualization

    DEFF Research Database (Denmark)

    Glückstad, Fumiko Kano; Herlau, Tue; Schmidt, Mikkel Nørgaard

    2013-01-01

    This work presents a conceptual framework for learning an ontological structure of domain knowledge, which combines Jaccard similarity coefficient with the Infinite Relational Model (IRM) by (Kemp et al. 2006) and its extended model, i.e. the normal-Infinite Relational Model (n-IRM) by (Herlau et...... al. 2012). The proposed approach is applied to a dataset where legal concepts related to the Japanese educational system are defined by the Japanese authorities according to the International Standard Classification of Education (ISCED). Results indicate that the proposed approach effectively...

  1. Knowledge deficiency of work-related radiation hazards associated with psychological distress among orthopedic surgeons

    Science.gov (United States)

    Fan, Guoxin; Wang, Yueye; Guo, Changfeng; Lei, Xuefeng; He, Shisheng

    2017-01-01

    Abstract Knowledge and concern degree about work-related radiation hazards remained unknown among orthopedic surgeons. The aim of the cross-sectional study is to investigate whether the knowledge degree of work-related radiation is associated with psychological distress among orthopedic surgeons. This cross-sectional study sent electronic questionnaire via WeChat to orthopedic surgeons nationwide. Concern and knowing degree over radiation exposure was evaluated by a single self-reported question. Professional evaluation of concern degree was reflected by general psychological distress, which was assessed with the Kessler 10 scale (K10) and depressive symptoms with the Center for Epidemiologic Studies Depression Scale (CES-D). Only 43.23% (115/266) respondents knew well about radiation and a total of 78.20% (208/266) respondents considered radiation exposure as a great concern. Among those who reported concerns about radiation exposure, a total of 57.69% (120/208) respondents reported knowing little about radiation. Respondents who reported concerns over radiation exposure were significantly associated with higher scores on CES-D and K10 (P < .05). Among respondents who reported concerns over radiation exposure, those who have fewer knowledge about radiation, had higher CES-D and K10 scores than those who knew well about radiation (P < .05). Among respondents who reported no concerns over radiation exposure, those who knew little about radiation still had higher CES-D and K10 scores (P < .05). Fewer radiation knowledge tends to induce more radiation concerns associated with higher psychological distress in orthopedic surgeons. Radiation knowledge should be enhanced for surgeons who daily work with radiation-related fluoroscopy. PMID:28538368

  2. Effectiveness of health education on Toxoplasma-related knowledge, behaviour, and risk of seroconversion in pregnancy.

    Science.gov (United States)

    Gollub, Erica L; Leroy, Valériane; Gilbert, Ruth; Chêne, Geneviève; Wallon, Martine

    2008-02-01

    We conducted a bibliographic literature search using MEDLINE to review the effectiveness of health education on Toxoplasma-related knowledge, behaviour, and risk of seroconversion in pregnant women. We pre-selected studies that used comparative study designs (randomized clinical trial, quasi-experimental design or historical control), that were conducted among pregnant women, and which employed specific, Toxoplasma-related outcome measures: knowledge, behaviour, or Toxoplasma infection rate. Four studies met the inclusion criteria. All had serious methodological flaws. A Belgian study reported a significant decrease in the incidence of Toxoplasma seroconversion after the introduction of intensive counselling for pregnant women about toxoplasmosis. In Poland, a significant increase in knowledge was observed after a multi-pronged, public health educational program was launched. In Canada, an increase in knowledge and prevention behaviours was reported in the intervention group receiving counselling by trained facilitators compared with the control group. In France, no significant changes in risk behaviour were observed following a physician-delivered intervention. This review highlights the weakness of the literature in the area and the lack of studies measuring actual seroconversion. There is suggestive evidence that health education approaches may help reduce risk of congenital toxoplasmosis but this problem requires further study using more rigorous research design and methodology.

  3. Examining Challenges Related to the Production of Actionable Climate Knowledge for Adaptation Decision-Making: A Focus on Climate Knowledge System Producers

    Science.gov (United States)

    Ernst, K.; Preston, B. L.; Tenggren, S.; Klein, R.; Gerger-Swartling, Å.

    2017-12-01

    Many challenges to adaptation decision-making and action have been identified across peer-reviewed and gray literature. These challenges have primarily focused on the use of climate knowledge for adaptation decision-making, the process of adaptation decision-making, and the needs of the decision-maker. Studies on climate change knowledge systems often discuss the imperative role of climate knowledge producers in adaptation decision-making processes and stress the need for producers to engage in knowledge co-production activities and to more effectively meet decision-maker needs. While the influence of climate knowledge producers on the co-production of science for adaptation decision-making is well-recognized, hardly any research has taken a direct approach to analyzing the challenges that climate knowledge producers face when undertaking science co-production. Those challenges can influence the process of knowledge production and may hinder the creation, utilization, and dissemination of actionable knowledge for adaptation decision-making. This study involves semi-structured interviews, focus groups, and participant observations to analyze, identify, and contextualize the challenges that climate knowledge producers in Sweden face as they endeavor to create effective climate knowledge systems for multiple contexts, scales, and levels across the European Union. Preliminary findings identify complex challenges related to education, training, and support; motivation, willingness, and culture; varying levels of prioritization; professional roles and responsibilities; the type and amount of resources available; and professional incentive structures. These challenges exist at varying scales and levels across individuals, organizations, networks, institutions, and disciplines. This study suggests that the creation of actionable knowledge for adaptation decision-making is not supported across scales and levels in the climate knowledge production landscape. Additionally

  4. Origin of the Nonsinusoidal current-phase relation of a superconducting bridge

    International Nuclear Information System (INIS)

    Sugahara, M.

    1977-01-01

    The current-phase relation of a long superconducting bridge is investigated with the use of the Aslamazov-Larkin model and the Ginzburg-Landau equation. The feedback effect of the supercurrent to the phase difference in the weak link is taken into consideration. The derived nonsinusoidal current-phase relation explains the experiments of Jackel et al. very well

  5. Investigation of Hong Kong doctors' current knowledge, beliefs, attitudes, confidence and practices: implications for the treatment of tobacco dependency.

    Science.gov (United States)

    Abdullah, Abu Saleh M; Rahman, A S M Mujibur; Suen, Chau Wai; Wing, Lau Sun; Ling, Lau Wai; Mei, Li Yuen; Tat, Lun Chung; Tai, Mak Nin; Wing, Tsai Nga; Yuen, Wu Tsz; Kwan, Yam H

    2006-10-01

    Physicians play a crucial role in promoting smoking cessation. However, there are lack of data on Chinese doctors' knowledge, beliefs, attitudes, confidence and usual practices in relation to smoking cessation. Understanding of these indicators is important in the design of any effective intervention program targeting doctors. To assess Chinese doctors' knowledge, beliefs, attitudes, confidence and usual practices in relation to smoking cessation, a mailed questionnaire survey was conducted among 4,000 doctors registered with the Hong Kong Medical Association (HKMA) in 2002. Of the 757 respondents (18.9% response rate), 78% were male, 94% were non-smokers and 50% had received no basic training on smoking cessation. More than half of the doctors did not hold adequate knowledge (53%) or favorable attitudes (55%) towards smoking cessation; 44% were less confident in their smoking cessation skills. About 77% of the doctors obtained information on their patients' smoking status and recorded it in their medical record, and 29% advised all smoking patients to quit. Doctors who gave smoking cessation advice were more likely to be aged above 50 years, with more than 30 years' practice experience, working in the private sector, non- or ex-smokers, with more positive beliefs towards smoking cessation, and with higher confidence in smoking cessation skills (p confidence on smoking cessation-related matters were also identified. The survey has shown that existing smoking cessation service provision in Hong Kong for patients who smoke is inadequate, and has identified a lack of smoking cessation skills among doctors. Action should be taken to train doctors in smoking cessation skills and encourage them to routinely establish the smoking status of their patients and to advise all smokers to quit smoking.

  6. Reciprocal Relations between Perceived Parental Knowledge and Adolescent Substance Use and Delinquency: The Moderating Role of Parent-Teen Relationship Quality

    Science.gov (United States)

    Abar, Caitlin C.; Jackson, Kristina M.; Wood, Mark

    2014-01-01

    The current study prospectively examined hypothesized short- and long-term reciprocal relations between perceived parental knowledge and adolescent heavy episodic drinking, marijuana use, and delinquency. Using the contextual model of parenting style (Darling & Steinberg, 1993), we examined the extent to which the bidirectional nature of…

  7. A Social-Learning Approach to Hazard-Related Knowledge Exchange: Boundary Workers at the Geoscience-Humanitarian Interface

    Science.gov (United States)

    Quinn, Keira; Hope, Max; McCloskey, John

    2014-05-01

    A Social-Learning Approach to Hazard-Related Knowledge Exchange: Boundary Workers at the Geoscience-Humanitarian Interface Keira Quinn (1), Dr Max Hope (1), Professor John McCloskey (1). (1)University of Ulster Peer-reviewed science has the potential to guide policy-makers and practitioners in developing robust responses to social problems and issues. Despite advances in hazard-related science, it can often be a challenge to translate findings into useful social applications. With natural hazards affecting 2.9 billion people between 2000 and 2012 the need for hazard science to be effectively communicated is undeniable. This is particularly so in humanitarian contexts as non-governmental organisations (NGOs) play a key role in the poorer nations most affected by natural disasters. Past methods of 'knowledge transfer' have tended to lead to misinterpretations and misrepresentations of science to the extent that it is often used incorrectly or not at all. 'Knowledge exchange' is currently heralded as a more effective means of bringing about successful communication and understanding, and is characterised by the presence of shared learning. Central to a knowledge exchange approach is an understanding of the social and organisational contexts within which learning takes place. Here we use Etienne Wenger's social-learning approach to analyse selected aspects of the social context influencing knowledge exchange across the geoscience-humanitarian interface. For Wenger (2000) Communities of Practice (CoP) are bounded organisational and social groups united by their own distinct values, goals and ways of working. The boundaries surrounding CoPs can act as barriers to knowledge exchange but can also create opportunities for new shared learning by challenging existing perspectives and practice. Drawing on the findings of ongoing qualitative research into communication and learning between earthquake scientists and humanitarian NGOs in UK/Ireland, this paper outlines a number

  8. Knowledge, attitudes and beliefs related to HIV/AIDS among adolescents in Malaysia.

    Science.gov (United States)

    Zulkifli, S N; Wong, Y L

    2002-03-01

    Findings on knowledge, attitudes and beliefs related to HIV/AIDS among 520 Malaysian adolescents, aged 15 to 21 years, based on a survey conducted in Peninsular Malaysia showed that the average score for knowledge on HIV/AIDS was high, and majority showed a positive attitude towards the disease. However, misconceptions regarding transmission and gender bias related to sexual behaviour and contracting the disease prevailed. Although 72 percent of the sexually-experienced did not use protection at first sexual intercourse, 80 percent did not perceive themselves to be at risk of contracting HIV/AIDS. A critical review of existing HIV/AIDS prevention programmes to focus on adolescent risk-taking behaviour and sexuality issues, including male-female negotiation skills, is warranted.

  9. Portuguese Coaches' Perceptions of and Preferences for Knowledge Sources Related to their Professional Background.

    Science.gov (United States)

    Mesquita, Isabel; Isidro, Sofia; Rosado, António

    2010-01-01

    The purpose of this study was to analyse Portuguese coaches' perceptions of, and preferences for, knowledge sources as related to professional background; namely academic education level, coach education level and coaching experience. The study's participants comprised 336 Portuguese coaches from twenty-two sports. A questionnaire was used to identify coaches' demographic characteristics and representations about their preferred sources of coaching knowledge. MANOVA using Tukey's HSD test was used to compare groups. The results highlighted that coaches perceived that coaching knowledge is built from a broad range of sources from personal coaching and playing experiences to more explicit formal, informal and non-formal learning situations. Results indicated that the coaches ascribed more importance to experiential sources such as working with experts, learning by doing, interacting with peer coaches and attending informal seminars and clinics, than to the formal learning situations provided by the national coaching certification programs. Differences, however, were found in that coaches who had a greater background within higher education (physical) and sport valued informal and non-formal learning sources more than did coaches who were defined as not coming from an academic background. The findings point to the importance of developing new learning, experientially-based, opportunities within the Portuguese context, where curricula content continues to be delivered via didactic means. Key pointsCoaches recognized that learning is obtained from a broad range of sources of coaching knowledge and each source has a particular role in the development of a coach.Experiential guided sources reached more importance to coaches as working with experts, learning by doing, attending seminars/clinics outside of the formal system and interaction with peers were the most acknowledged.The only source that is related to formal learning, national certification programs, was

  10. Elicitors as alternative strategy to pesticides in grapevine? Current knowledge on their mode of action from controlled conditions to vineyard.

    Science.gov (United States)

    Delaunois, Bertrand; Farace, Giovanni; Jeandet, Philippe; Clément, Christophe; Baillieul, Fabienne; Dorey, Stéphan; Cordelier, Sylvain

    2014-04-01

    Development and optimisation of alternative strategies to reduce the use of classic chemical inputs for protection against diseases in vineyard is becoming a necessity. Among these strategies, one of the most promising consists in the stimulation and/or potentiation of the grapevine defence responses by the means of elicitors. Elicitors are highly diverse molecules both in nature and origins. This review aims at providing an overview of the current knowledge on these molecules and will highlight their potential efficacy from the laboratory in controlled conditions to vineyards. Recent findings and concepts (especially on plant innate immunity) and the new terminology (microbe-associated molecular patterns, effectors, etc.) are also discussed in this context. Other objectives of this review are to highlight the difficulty of transferring elicitors use and results from the controlled conditions to the vineyard, to determine their practical and effective use in viticulture and to propose ideas for improving their efficacy in non-controlled conditions.

  11. Oral cancer--current knowledge, practices and implications for training among an Irish general medical practitioner cohort.

    LENUS (Irish Health Repository)

    Ni Riordain, Richeal

    2009-11-01

    This study investigated the current knowledge and practices of general medical practitioners (GMPs) in Ireland regarding the examination of the oral cavity and the detection of oral malignancy and the training they had received at both undergraduate and postgraduate level and since commencing in practice. A questionnaire survey of GMPs in Ireland was conducted. One hundred and fifty four (65.3%) of the practitioners reported regularly examining the oral mucosa of their patients. Almost half of these (n=68) further qualified this response by stating that they only examined the oral mucosa if the patient reported pain in this area or if the patient specifically requested an oral examination for some reason. Eighty one (34.3%) practitioners surveyed felt confident in their ability to detect oral malignancies with the remaining two thirds unsure of whether they would be able to detect oral cancer. There was a significant association between the undergraduate and postgraduate teaching on examination of the oral cavity and whether practitioners felt confident in their ability to detect oral cancer [chi(2)(1)=4.811, p<0.05]. A statistically significant association was also found between the undergraduate and postgraduate teaching on the diagnosis of oral malignant disease and whether practitioners felt confident in their ability to detect oral cancer [chi(2)(1)=6.194, p<0.05]. In conclusion the level of knowledge of Irish general medical practitioners needs to be addressed with appropriate initiatives both at undergraduate level and via CME.

  12. Transformational leadership and safety performance among nurses: the mediating role of knowledge-related job characteristics.

    Science.gov (United States)

    Lievens, Ilse; Vlerick, Peter

    2014-03-01

    To report the impact of transformational leadership on two dimensions of nurses' safety performance (i.e. safety compliance and safety participation) and to study the mediating role of knowledge-related job characteristics in this relationship. Safety performance refers to the behaviours that employees exhibit to adhere to safety guidelines and to promote health and safety at their workplace. Nurses' safety performance is a major challenge for healthcare settings, urging the need to identify the key determinants and psychological mechanisms that influence it. A cross-sectional survey study. The study was carried out in September 2010 in a large Belgian hospital. We used self-administered questionnaires; 152 nurses participated. The hypotheses were tested using hierarchical regression analyses. In line with our first hypothesis, the results show that transformational leadership exerted a significant positive impact on both dimensions of nurses' safety performance. This positive relation was mediated by knowledge-related job characteristics, supporting our second hypothesis. Head nurses' transformational leadership can enhance nurses' compliance with and participation in safety. Furthermore, transformational head nurses are able to influence the perception that their nurses have about the kind and amount of knowledge in their job, which can also lead to increases in both dimensions of nurses' safety performance. This study therefore demonstrates the key impact that transformational head nurses have, both directly and indirectly, on the safety performance of their nurses. © 2013 John Wiley & Sons Ltd.

  13. Belief, Knowledge and Understanding. How to Deal with the Relations Between Different Cultural Perspectives in Classrooms

    Science.gov (United States)

    Moreira-dos-Santos, Frederik; El-Hani, Charbel N.

    2017-05-01

    This article discusses how to deal with the relations between different cultural perspectives in classrooms, based on a proposal for considering understanding and knowledge as goals of science education, inspired by Dewey's naturalistic humanism. It thus combines educational and philosophical interests. In educational terms, our concerns relate to how science teachers position themselves in multicultural classrooms. In philosophical terms, we are interested in discussing the relations between belief, understanding, and knowledge under the light of Dewey's philosophy. We present a synthesis of Dewey's theory of inquiry through his naturalistic humanism and discuss its implications for the concepts of belief, understanding, and knowledge, as well as for the goals of science teaching. In particular, we highlight problems arising in the context of possible conflicts between scientific and religious claims in the school environment that result from totalitarian positions. We characterize an individual's position as totalitarian if he or she takes some way of thinking as the only one capable of expressing the truth about all that exists in the world, lacks open-mindedness to understand different interpretative perspectives, and attempts to impose her or his interpretation about the facts to others by violent means or not. From this stance, any other perspective is taken to be false a priori and, accordingly, as a putative target to be suppressed or adapted to the privileged way of thinking. We argue, instead, for a more fallibilist evaluation of our own beliefs and a more respectful appraisal of the diversity of students' beliefs by both students and teachers.

  14. A review of current knowledge on toxic benthic freshwater cyanobacteria--ecology, toxin production and risk management.

    Science.gov (United States)

    Catherine, Quiblier; Susanna, Wood; Isidora, Echenique-Subiabre; Mark, Heath; Aurélie, Villeneuve; Jean-François, Humbert

    2013-10-01

    Benthic cyanobacteria are found globally in plethora of environments. Although they have received less attention than their planktonic freshwater counterparts, it is now well established that they produce toxins and reports of their involvement in animal poisonings have increased markedly during the last decade. Most of the known cyanotoxins have been identified from benthic cyanobacteria including: the hepatotoxic microcystins, nodularins and cylindrospermopsins, the neurotoxic saxitoxins, anatoxin-a and homoanatoxin-a and dermatotoxins, such as lyngbyatoxin. In most countries, observations of toxic benthic cyanobacteria are fragmented, descriptive and in response to animal toxicosis events. Only a limited number of long-term studies have aimed to understand why benthic proliferations occur, and/or how toxin production is regulated. These studies have shown that benthic cyanobacterial blooms are commonly a mixture of toxic and non-toxic genotypes and that toxin concentrations can be highly variable spatially and temporally. Physiochemical parameters responsible for benthic proliferation vary among habitat type with physical disturbance (e.g., flow regimes, wave action) and nutrients commonly identified as important. As climatic conditions change and anthropogenic pressures on waterways increase, it seems likely that the prevalence of blooms of benthic cyanobacteria will increase. In this article we review current knowledge on benthic cyanobacteria: ecology, toxin-producing species, variables that regulate toxin production and bloom formation, their impact on aquatic and terrestrial organisms and current monitoring and management strategies. We suggest research needs that will assist in filling knowledge gaps and ultimately allow more robust monitoring and management protocols to be developed. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Knowledge and Attitudes of Patients and Their Relatives Toward Electroconvulsive Therapy in China.

    Science.gov (United States)

    Li, Yang; An, Feng-Rong; Zhu, Hui; Chiu, Helen F K; Ungvari, Gabor S; H Ng, Chee; Lai, Kelly Y C; Xiang, Yu-Tao

    2016-10-01

    To examine the knowledge and attitudes of patients and their relatives as well as patients' subjective experience with electroconvulsive therapy (ECT) in China. Up to 420 responders including patients receiving ECT (n = 210) and their relatives (n = 210) were assessed with self-reported questionnaires. Patients and their relatives did not receive adequate information before ECT, particularly about the mode of its delivery, risks, and adverse effects. The most common adverse effect of ECT reported by patients was memory impairment. Both patients and their relatives had positive attitudes toward ECT and appeared satisfied with its therapeutic effects. Mental health professionals need to address the inadequate information on ECT provided to patients and their relatives prior to the treatment. © 2015 Wiley Periodicals, Inc.

  16. Current Status of Knowledge, Attitudes and Practices towards Healthcare Ethics among Doctors and Nurses from Northern India - A Multicentre Study

    Directory of Open Access Journals (Sweden)

    Mukul Chopra

    2013-07-01

    Full Text Available Background: Recent raise in litigation againsthealthcare practitioners is definitely an issueof immediate concern and may reflect an in-crease in unethical practices by them. Profes-sional relations between physicians and nursesmay have differences with respect to their atti-tudes towards patient-care. Aim and Objec-tives: To assess the knowledge of, and attitudesto healthcare ethics among north Indian physi-cians and nurses. Material and Methods: Thepresent cross sectional study was carried outamong 298 physicians and 107 nurses of threemedical colleges of northern India in the monthof July-August 2011 using pretested self ad-ministered questionnaire. Data analysis wasdone using SPSS version 20. Result and Con-clusion: There was a statistically significantdifference between the opinion of physiciansand nurses with respect to adherence to confi-dentiality, paternalistic attitude of doctors (doc-tors should do their best for the patient irre-spective of the patient’s opinion, informingclose relatives of a patients for consent proce-dures. The study highlighted gaps in the knowl-edge about practical aspects of health care eth-ics among physicians and nurses which theyencounter in day to day practice at workplace.Measures of workplace education like sensiti-zation workshops, CME’s, conferences onhealth care ethics would assist in bridging thisgap to a certain extent.

  17. The Link between Knowledge, Attitudes and Practices in Relation to Atmospheric Haze Pollution in Peninsular Malaysia

    Science.gov (United States)

    De Pretto, Laura; Acreman, Stephen; Ashfold, Matthew J.; Mohankumar, Suresh K.; Campos-Arceiz, Ahimsa

    2015-01-01

    Transboundary haze episodes caused by seasonal forest fires have become a recurrent phenomenon in Southeast Asia, with serious environmental, economic, and public health implications. Here we present a cross-sectional survey conducted among people in Kuala Lumpur and surrounds to assess the links between knowledge, attitudes, and practices in relation to the transboundary haze episodes. Of 305 respondents, 125 were amateur athletes participating in a duathlon event and the remainder were surveyed in an inner-city shopping mall. Across the whole sample, people who possessed more factual information about the haze phenomenon showed significantly higher levels of concern. Duathletes were more knowledgeable than non-duathletes and also more concerned about the negative effects of haze, especially on health. For all people who regularly practice outdoor sports (including people interviewed at the shopping mall), higher levels of knowledge and concerned attitudes translated into a greater likelihood of engaging in protective practices, such as cancelling their outdoor training sessions, while those with greater knowledge were more likely to check the relevant air pollution index on a daily basis. Our results indicate that the provision of accurate and timely information about air quality to residents will translate into beneficial practices, at least among particularly exposed individuals, such as amateur athletes who regularly practice outdoor sports. PMID:26646896

  18. The Link between Knowledge, Attitudes and Practices in Relation to Atmospheric Haze Pollution in Peninsular Malaysia.

    Directory of Open Access Journals (Sweden)

    Laura De Pretto

    Full Text Available Transboundary haze episodes caused by seasonal forest fires have become a recurrent phenomenon in Southeast Asia, with serious environmental, economic, and public health implications. Here we present a cross-sectional survey conducted among people in Kuala Lumpur and surrounds to assess the links between knowledge, attitudes, and practices in relation to the transboundary haze episodes. Of 305 respondents, 125 were amateur athletes participating in a duathlon event and the remainder were surveyed in an inner-city shopping mall. Across the whole sample, people who possessed more factual information about the haze phenomenon showed significantly higher levels of concern. Duathletes were more knowledgeable than non-duathletes and also more concerned about the negative effects of haze, especially on health. For all people who regularly practice outdoor sports (including people interviewed at the shopping mall, higher levels of knowledge and concerned attitudes translated into a greater likelihood of engaging in protective practices, such as cancelling their outdoor training sessions, while those with greater knowledge were more likely to check the relevant air pollution index on a daily basis. Our results indicate that the provision of accurate and timely information about air quality to residents will translate into beneficial practices, at least among particularly exposed individuals, such as amateur athletes who regularly practice outdoor sports.

  19. The Link between Knowledge, Attitudes and Practices in Relation to Atmospheric Haze Pollution in Peninsular Malaysia.

    Science.gov (United States)

    De Pretto, Laura; Acreman, Stephen; Ashfold, Matthew J; Mohankumar, Suresh K; Campos-Arceiz, Ahimsa

    2015-01-01

    Transboundary haze episodes caused by seasonal forest fires have become a recurrent phenomenon in Southeast Asia, with serious environmental, economic, and public health implications. Here we present a cross-sectional survey conducted among people in Kuala Lumpur and surrounds to assess the links between knowledge, attitudes, and practices in relation to the transboundary haze episodes. Of 305 respondents, 125 were amateur athletes participating in a duathlon event and the remainder were surveyed in an inner-city shopping mall. Across the whole sample, people who possessed more factual information about the haze phenomenon showed significantly higher levels of concern. Duathletes were more knowledgeable than non-duathletes and also more concerned about the negative effects of haze, especially on health. For all people who regularly practice outdoor sports (including people interviewed at the shopping mall), higher levels of knowledge and concerned attitudes translated into a greater likelihood of engaging in protective practices, such as cancelling their outdoor training sessions, while those with greater knowledge were more likely to check the relevant air pollution index on a daily basis. Our results indicate that the provision of accurate and timely information about air quality to residents will translate into beneficial practices, at least among particularly exposed individuals, such as amateur athletes who regularly practice outdoor sports.

  20. The Current State of Global Activities Related to Deep-sea Mineral Exploration and Mining

    OpenAIRE

    Petersen, Sven; Krätschell, Anna; Hannington, Mark D.

    2016-01-01

    Deep-sea mining is seen as a potential way to provide future secure metal supply to global markets. The current rush to the seafloor in areas beyond national jurisdiction indicates that sound knowledge of the geological characteritics of the various commodities, a realistic resource assessment, and a social and political discussion about the cons and pros of their exploitation that is based on facts, not myths, is required. This contribution provides the most recent information on...

  1. Virtualization and New Geographies of Knowledge in Higher Education: Possibilities for the Transformation of Knowledge, Pedagogic Relations and Learner Identities

    Science.gov (United States)

    Taylor, Carol A.; Dunne, Mairead

    2011-01-01

    This article considers some of the ways in which the transformative power of Web 2.0 digital technology is reconfiguring learning, knowledge and academic identities in the contemporary university. Through a focus on five specific examples, we consider the impact of virtualization processes on spatiality, materiality and embodiment, and pedagogic…

  2. Hall magnetohydrodynamic effects for current sheet flapping oscillations related to the magnetic double gradient mechanism

    International Nuclear Information System (INIS)

    Erkaev, N. V.; Semenov, V. S.; Biernat, H. K.

    2010-01-01

    Hall magnetohydrodynamic model is investigated for current sheet flapping oscillations, which implies a gradient of the normal magnetic field component. For the initial undisturbed current sheet structure, the normal magnetic field component is assumed to have a weak linear variation. The profile of the electric current velocity is described by hyperbolic functions with a maximum at the center of the current sheet. In the framework of this model, eigenfrequencies are calculated as functions of the wave number for the ''kink'' and ''sausage'' flapping wave modes. Because of the Hall effects, the flapping eigenfrequency is larger for the waves propagating along the electric current, and it is smaller for the opposite wave propagation with respect to the current. The asymmetry of the flapping wave propagation, caused by Hall effects, is pronounced stronger for thinner current sheets. This is due to the Doppler effect related to the electric current velocity.

  3. Considering Human Capital Theory in Assessment and Training: Mapping the Gap between Current Skills and the Needs of a Knowledge-Based Economy in Northeast Iowa

    Science.gov (United States)

    Mihm-Herold, Wendy

    2010-01-01

    In light of the current economic downturn, thousands of Iowans are unemployed and this is the ideal time to build the skills of the workforce to compete in the knowledge-based economy so businesses and entrepreneurs can compete in a global economy. A tool for assessing the skills and knowledge of dislocated workers and students as well as…

  4. Consumers’ Knowledge Related To Food Products And Their Attitudes To Health Risks

    Directory of Open Access Journals (Sweden)

    Ahmet Topuzoglu

    2007-08-01

    Full Text Available The objective of this study is to determine the knowledge and attitudes related to food purchase among individuals who apply to a primary health care center in Umraniye, Istanbul. In this descriptive study, data was collected through face to face interviews from 167 individuals who had applied to a primary health care center. The questionnaire form included sociodemographic variables as well as a group of questions that determine knowledge and attitudes related to food purchasing, consuming and food poisoning. Besides descriptive statistics, factor analysis was used in order to determine the attitudinal patterns related to food purchasing. The mean age of the 167 participants was 32.4±11.0. Among all 81.4% were female. The attack rate of food poisoning within the last one year was determined as 3.3%. Only 18.6% of the participants reported that they knew the organizations which monitor the safety of food products. The most approved attitude among the participants was the concern related to the durability of the package of the food products (92.8%. The attitude of returning the spoiled food back was 83.2%. Among all, 52.1% of the participants approved the attitude of reading food labels. 39.6% of the participants did not consider the expiry dates while 28.8% did not consider the mineral contents of the products. Factor analyses revealed eight factors for explaining the attitudinal patterns related to food purchasing. There is lack of knowledge concerning the selection of the appropriate food product for healthy nutrition. Reading product labels was not frequent during food purchase and so should be considered as an intervention area for health education. The consumers should get to know and access the organizations which monitor and control the safety of food products. [TAF Prev Med Bull. 2007; 6(4: 253-258

  5. Consumers’ Knowledge Related To Food Products And Their Attitudes To Health Risks

    Directory of Open Access Journals (Sweden)

    Ahmet Topuzoglu

    2007-08-01

    Full Text Available The objective of this study is to determine the knowledge and attitudes related to food purchase among individuals who apply to a primary health care center in Umraniye, Istanbul. In this descriptive study, data was collected through face to face interviews from 167 individuals who had applied to a primary health care center. The questionnaire form included sociodemographic variables as well as a group of questions that determine knowledge and attitudes related to food purchasing, consuming and food poisoning. Besides descriptive statistics, factor analysis was used in order to determine the attitudinal patterns related to food purchasing. The mean age of the 167 participants was 32.4±11.0. Among all 81.4% were female. The attack rate of food poisoning within the last one year was determined as 3.3%. Only 18.6% of the participants reported that they knew the organizations which monitor the safety of food products. The most approved attitude among the participants was the concern related to the durability of the package of the food products (92.8%. The attitude of returning the spoiled food back was 83.2%. Among all, 52.1% of the participants approved the attitude of reading food labels. 39.6% of the participants did not consider the expiry dates while 28.8% did not consider the mineral contents of the products. Factor analyses revealed eight factors for explaining the attitudinal patterns related to food purchasing. There is lack of knowledge concerning the selection of the appropriate food product for healthy nutrition. Reading product labels was not frequent during food purchase and so should be considered as an intervention area for health education. The consumers should get to know and access the organizations which monitor and control the safety of food products. [TAF Prev Med Bull 2007; 6(4.000: 253-258

  6. Knowledge, attitudes and beliefs related to seasonal influenza vaccine among pregnant women in Thailand.

    Science.gov (United States)

    Ditsungnoen, Darunee; Greenbaum, Adena; Praphasiri, Prabda; Dawood, Fatimah S; Thompson, Mark G; Yoocharoen, Pornsak; Lindblade, Kim A; Olsen, Sonja J; Muangchana, Charung

    2016-04-19

    In 2009, Thailand recommended pregnant women be prioritized for influenza vaccination. Vaccine uptake among Thai pregnant women is lower than other high-risk groups. During December 2012-April 2013, we conducted a cross-sectional survey of a convenience sample of Thai pregnant women aged ≥ 15 years attending antenatal clinics at public hospitals in 8 of 77 provinces. A self-administered questionnaire covered knowledge, attitudes, and beliefs related to influenza vaccination using the Health Belief Model. We examined factors associated with willingness to be vaccinated using log-binomial regression models. The survey was completed by 1031 (96%) of 1072 pregnant women approached. A total of 627 (61%) women had heard about influenza vaccine and were included in the analysis, of whom 262 (42%) were willing to be vaccinated, 155 (25%) had received a healthcare provider recommendation for influenza vaccination and 25 (4%) had received the influenza vaccine during the current pregnancy. In unadjusted models, high levels of perceptions of susceptibility (prevalence ratio [PR] 1.5, 95% CI 1.2-2.0), high levels of belief in the benefits of vaccination (PR 2.3, 95% CI 1.7-3.1), moderate (PR 1.7, 95% CI 1.2-2.3) and high (PR 3.4, 95% CI 2.6-4.5) levels of encouragement by others to be vaccinated (i.e., cues to action) were positively associated with willingness to be vaccinated. Moderate (PR 0.5, 95% CI 0.4-0.7) and high levels of (PR 0.5, 95% CI 0.4-0.8) perceived barriers were negatively associated with willingness to be vaccinated. In the final adjusted model, only moderate (PR 1.5, 95% CI 1.1-2.0) and high levels of cues to action (PR 2.7, 95% CI 2.0-3.6) were statistically associated with willingness to be vaccinated. Cues to action were associated with willingness to be vaccinated and can be used to inform communication strategies during the vaccine campaign to increase influenza vaccination among Thai pregnant women. Published by Elsevier Ltd.

  7. The strategic management of organizational knowledge exchange related to hospital quality measurement and reporting.

    Science.gov (United States)

    Rangachari, Pavani

    2008-01-01

    CONTEXT/PURPOSE: With the growing momentum toward hospital quality measurement and reporting by public and private health care payers, hospitals face increasing pressures to improve their medical record documentation and administrative data coding accuracy. This study explores the relationship between the organizational knowledge-sharing structure related to quality and hospital coding accuracy for quality measurement. Simultaneously, this study seeks to identify other leadership/management characteristics associated with coding for quality measurement. Drawing upon complexity theory, the literature on "professional complex systems" has put forth various strategies for managing change and turnaround in professional organizations. In so doing, it has emphasized the importance of knowledge creation and organizational learning through interdisciplinary networks. This study integrates complexity, network structure, and "subgoals" theories to develop a framework for knowledge-sharing network effectiveness in professional complex systems. This framework is used to design an exploratory and comparative research study. The sample consists of 4 hospitals, 2 showing "good coding" accuracy for quality measurement and 2 showing "poor coding" accuracy. Interviews and surveys are conducted with administrators and staff in the quality, medical staff, and coding subgroups in each facility. Findings of this study indicate that good coding performance is systematically associated with a knowledge-sharing network structure rich in brokerage and hierarchy (with leaders connecting different professional subgroups to each other and to the external environment), rather than in density (where everyone is directly connected to everyone else). It also implies that for the hospital organization to adapt to the changing environment of quality transparency, senior leaders must undertake proactive and unceasing efforts to coordinate knowledge exchange across physician and coding subgroups and

  8. Knowledge, attitudes, practices, and barriers related to research utilization: a survey among pharmacists in Malaysia.

    Science.gov (United States)

    Tan, Sin Yee; Hatah, Ernieda

    2017-04-01

    Background Research utilization is part of evidence-based practice referring to the process of reviewing and critiquing scientific research and applying the findings to one's own clinical practice. Many studies on research utilization have been conducted with doctors and nurses, but to our knowledge, none have been investigated amongst pharmacists. Objective To assess research utilization and its barriers among pharmacists and identify potential influencing factors. Setting Malaysia. Methods This cross-sectional survey was administered online and by mail to a convenient sample of pharmacists working in hospitals, health clinics, and retail pharmacies in rural and urban areas. Main outcome measure Pharmacists' research utilization knowledge, attitudes, and practices. Results Six hundred surveys were mailed to potential respondents, and 466 were returned (77.7% response rate). Twenty-eight respondents completed the survey online. The respondents' research utilization knowledge, attitudes, and practices were found to be moderate. Research utilization was associated with respondents' knowledge and attitude scores (P < 0.001). When factors related to research utilization were modelled, higher educational level was associated with higher level of research utilization (P < 0.001) while less involvement in journal clubs, more years of service (3-7 years and more than 7 years) were associated with low and moderate research utilization, respectively. The main reported barrier to research utilization was lack of sufficient authority to change patient care procedures. Conclusion Pharmacists' research utilization knowledge, attitudes, and practices can be improved by encouraging pharmacists to pursue higher degrees, promoting active participation in institutions' journal clubs, and introducing senior clinical pharmacist specialization.

  9. [Investigation on malaria knowledge and demands on related training for CDC staff in Qinghai Province, China].

    Science.gov (United States)

    Shao-Sen, Zhang; Hui-Xia, Cai; Hong, Tu; He, Yan; Na, Liu; Jun-Ying, Ma

    2017-04-07

    To investigate the malaria knowledge of CDC staff and their demands on related training in malaria non-endemic areas, so as to provide the reference for planning the appropriate curriculum. All the participants who were the staff of county CDCs all over Qinghai Province and attended the provincial training workshop were surveyed. A self-administered questionnaire survey was carried out and the data was statistically analyzed. A total of 115 participants were involved in this survey. They were mostly (85.21%) from county CDCs. The general knowledge of malaria among the respondents was well, and the average rate of correct answers was 70.35%. However, the answers to the general knowledge of malaria and anti-malaria treatment were not well enough. The rates of correct answers were 61.96% and 48.99% respectively. The differences among the groups of job title ranking, department of working and level of CDC were not significant ( F = 0.13-2.02, all P > 0.05). The number of correct answers was significantly increased after the training course. The average score after the training was 79.20±15.16 while the pre-training score was 70.34±17.46 ( t = 3.86, P training as 80% of the respondents voted "Yes", according to the demand analysis. There was no significant difference among the different groups ( F = 0.61-3.11, both P > 0.05). The malaria knowledge is well mastered by the staff of CDCs in Qinghai Province, and the further training courses are requested and addressed in the target areas such as general malaria knowledge, anti-malaria treatment, malaria surveillance and response.

  10. Experience of Use of Knowledge Relative Assessment System for Training in Area of Civil Engineering

    Directory of Open Access Journals (Sweden)

    Romanova Elena

    2017-01-01

    Full Text Available Nowadays E-Learning is becoming more and more relevant in training civil engineers. Electronic resources are used for classroom activities and for independent work. It allows allocating extra time for development of practical skills. Experience of remote knowledge control application in the educational process of Moscow State University of Civil Engineering is presented in the article. The control system is called Knowledge Relative Assessment System using Bekker's method. The following steps of system using are described in detail in the article: loading test material, action of users, protection from wrong acts and calculation of rating. The main merits and demerits from the point of view of teachers and students are listed.

  11. Knowledge and insight in relation to functional remission in patients with long-term psychotic disorders

    DEFF Research Database (Denmark)

    Alenius, Malin; Hammarlund-Udenaes, Margareta; Hartvig, Per

    2009-01-01

    : To investigate the knowledge and insight in relation to treatment response. METHODS: A naturalistic study was performed using patient interviews and information gathered from patient drug charts. Apart from the rating scales used for classification of treatment response (CANSEPT method), the SPKS knowledge......BACKGROUND: Patients with psychotic symptoms often respond poorly to treatment. Outcomes can be affected by biological, physiological and psychological factors according to the vulnerability-stress model. The patient's coping strategies and beliefs have been correlated with outcomes. OBJECTIVES...... of illness and drugs rating scale was utilized. RESULTS: In the group of patients in functional remission (FR; n = 38), 37% had insight into their illness as compared to 10% among those not in functional remission (non-FR; n = 78; P strategy for responding...

  12. Using affective knowledge to generate and validate a set of emotion-related, action words

    Directory of Open Access Journals (Sweden)

    Emma Portch

    2015-07-01

    Full Text Available Emotion concepts are built through situated experience. Abstract word meaning is grounded in this affective knowledge, giving words the potential to evoke emotional feelings and reactions (e.g., Vigliocco et al., 2009. In the present work we explore whether words differ in the extent to which they evoke ‘specific’ emotional knowledge. Using a categorical approach, in which an affective ‘context’ is created, it is possible to assess whether words proportionally activate knowledge relevant to different emotional states (e.g., ‘sadness’, ‘anger’, Stevenson, Mikels & James, 2007a. We argue that this method may be particularly effective when assessing the emotional meaning of action words (e.g., Schacht & Sommer, 2009. In study 1 we use a constrained feature generation task to derive a set of action words that participants associated with six, basic emotional states (see full list in Appendix S1. Generation frequencies were taken to indicate the likelihood that the word would evoke emotional knowledge relevant to the state to which it had been paired. In study 2 a rating task was used to assess the strength of association between the six most frequently generated, or ‘typical’, action words and corresponding emotion labels. Participants were presented with a series of sentences, in which action words (typical and atypical and labels were paired e.g., “If you are feeling ‘sad’ how likely would you be to act in the following way?” … ‘cry.’ Findings suggest that typical associations were robust. Participants always gave higher ratings to typical vs. atypical action word and label pairings, even when (a rating direction was manipulated (the label or verb appeared first in the sentence, and (b the typical behaviours were to be performed by the rater themselves, or others. Our findings suggest that emotion-related action words vary in the extent to which they evoke knowledge relevant for different emotional states. When

  13. Using affective knowledge to generate and validate a set of emotion-related, action words.

    Science.gov (United States)

    Portch, Emma; Havelka, Jelena; Brown, Charity; Giner-Sorolla, Roger

    2015-01-01

    Emotion concepts are built through situated experience. Abstract word meaning is grounded in this affective knowledge, giving words the potential to evoke emotional feelings and reactions (e.g., Vigliocco et al., 2009). In the present work we explore whether words differ in the extent to which they evoke 'specific' emotional knowledge. Using a categorical approach, in which an affective 'context' is created, it is possible to assess whether words proportionally activate knowledge relevant to different emotional states (e.g., 'sadness', 'anger', Stevenson, Mikels & James, 2007a). We argue that this method may be particularly effective when assessing the emotional meaning of action words (e.g., Schacht & Sommer, 2009). In study 1 we use a constrained feature generation task to derive a set of action words that participants associated with six, basic emotional states (see full list in Appendix S1). Generation frequencies were taken to indicate the likelihood that the word would evoke emotional knowledge relevant to the state to which it had been paired. In study 2 a rating task was used to assess the strength of association between the six most frequently generated, or 'typical', action words and corresponding emotion labels. Participants were presented with a series of sentences, in which action words (typical and atypical) and labels were paired e.g., "If you are feeling 'sad' how likely would you be to act in the following way?" … 'cry.' Findings suggest that typical associations were robust. Participants always gave higher ratings to typical vs. atypical action word and label pairings, even when (a) rating direction was manipulated (the label or verb appeared first in the sentence), and (b) the typical behaviours were to be performed by the rater themselves, or others. Our findings suggest that emotion-related action words vary in the extent to which they evoke knowledge relevant for different emotional states. When measuring affective grounding, it may then be

  14. Asymmetric current-phase relation due to spin-orbit interaction in semiconductor nanowire Josephson junction

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, Tomohiro; Eto, Mikio [Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan); Nazarov, Yuli V. [Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands (Netherlands)

    2013-12-04

    We theoretically study the current-phase relation in semiconductor nanowire Josephson junction in the presence of spin-orbit interaction. In the nanowire, the impurity scattering with strong SO interaction is taken into account using the random matrix theory. In the absence of magnetic field, the Josephson current I and phase difference φ between the superconductors satisfy the relation of I(φ) = –I(–φ). In the presence of magnetic field along the nanowire, the interplay between the SO interaction and Zeeman effect breaks the current-phase relation of I(φ) = –I(–φ). In this case, we show that the critical current depends on the current direction, which qualitatively agrees with recent experimental findings.

  15. Situationally-sensitive knowledge translation and relational decision making in hyperacute stroke: a qualitative study.

    Directory of Open Access Journals (Sweden)

    Madeleine J Murtagh

    Full Text Available Stroke is a leading cause of disability. Early treatment of acute ischaemic stroke with rtPA reduces the risk of longer term dependency but carries an increased risk of causing immediate bleeding complications. To understand the challenges of knowledge translation and decision making about treatment with rtPA in hyperacute stroke and hence to inform development of appropriate decision support we interviewed patients, their family and health professionals. The emergency setting and the symptomatic effects of hyper-acute stroke shaped the form, content and manner of knowledge translation to support decision making. Decision making about rtPA in hyperacute stroke presented three conundrums for patients, family and clinicians. 1 How to allow time for reflection in a severely time-limited setting. 2 How to facilitate knowledge translation regarding important treatment risks and benefits when patient and family capacity is blunted by the effects and shock of stroke. 3 How to ensure patient and family views are taken into account when the situation produces reliance on the expertise of clinicians. Strategies adopted to meet these conundrums were fourfold: face to face communication; shaping decisions; incremental provision of information; and communication tailored to the individual patient. Relational forms of interaction were understood to engender trust and allay anxiety. Shaping decisions with patients was understood as an expression of confidence by clinicians that helped alleviate anxiety and offered hope and reassurance to patients and their family experiencing the shock of the stroke event. Neutral presentations of information and treatment options promoted uncertainty and contributed to anxiety. 'Drip feeding' information created moments for reflection: clinicians literally made time. Tailoring information to the particular patient and family situation allowed clinicians to account for social and emotional contexts. The principal responses to

  16. Is Judgement of Biotechnological Ethical Aspects Related to High School Students' Knowledge?

    Science.gov (United States)

    Črne-Hladnik, Helena; Hladnik, Aleš; Javornik, Branka; Košmelj, Katarina; Peklaj, Cirila

    2012-05-01

    Quantitative and qualitative studies of various aspects of the perception of biotechnology were conducted among 469 Slovenian high school students of average age 17 years. Our research aimed to explore relationships among students' pre-knowledge of molecular and human genetics, and their attitudes to four specific biotechnological applications. These applications-Bt corn, genetically modified (GM) salmon, somatic and germ line gene therapy (GT)-were investigated from the viewpoints of usefulness, moral acceptance and risk perception. In addition, patterns and quality of moral reasoning related to the biotechnological applications from the aspect of moral acceptability were examined. Clear gender differences were found regarding the relationship between our students' pre-knowledge of genetics and their attitudes to biotechnological applications. While females with a better genetics background expressed a higher risk perception in the case of GM salmon, their similarly well-educated male colleagues emphasized the risk associated with the use of germ line GT. With all four biotechnological applications, patterns of both rationalistic-deontological and teleological-and intuitive moral reasoning were identified. Students with poorer genetics pre-knowledge applied an intuitive pattern of moral reasoning more frequently than their peers with better pre-knowledge. A pattern of emotive reasoning was detected only in the case of GM salmon. A relatively low quality of students' moral reasoning, as demonstrated by their brief and small number of supporting justifications (explanations), show that there is a strong need for practising skills of argumentation about socio-scientific issues in Slovenian high schools on a much larger scale. The implications for future research and classroom applications are discussed.

  17. Situationally-sensitive knowledge translation and relational decision making in hyperacute stroke: a qualitative study.

    Science.gov (United States)

    Murtagh, Madeleine J; Burges Watson, Duika L; Jenkings, K Neil; Lie, Mabel L S; Mackintosh, Joan E; Ford, Gary A; Thomson, Richard G

    2012-01-01

    Stroke is a leading cause of disability. Early treatment of acute ischaemic stroke with rtPA reduces the risk of longer term dependency but carries an increased risk of causing immediate bleeding complications. To understand the challenges of knowledge translation and decision making about treatment with rtPA in hyperacute stroke and hence to inform development of appropriate decision support we interviewed patients, their family and health professionals. The emergency setting and the symptomatic effects of hyper-acute stroke shaped the form, content and manner of knowledge translation to support decision making. Decision making about rtPA in hyperacute stroke presented three conundrums for patients, family and clinicians. 1) How to allow time for reflection in a severely time-limited setting. 2) How to facilitate knowledge translation regarding important treatment risks and benefits when patient and family capacity is blunted by the effects and shock of stroke. 3) How to ensure patient and family views are taken into account when the situation produces reliance on the expertise of clinicians. Strategies adopted to meet these conundrums were fourfold: face to face communication; shaping decisions; incremental provision of information; and communication tailored to the individual patient. Relational forms of interaction were understood to engender trust and allay anxiety. Shaping decisions with patients was understood as an expression of confidence by clinicians that helped alleviate anxiety and offered hope and reassurance to patients and their family experiencing the shock of the stroke event. Neutral presentations of information and treatment options promoted uncertainty and contributed to anxiety. 'Drip feeding' information created moments for reflection: clinicians literally made time. Tailoring information to the particular patient and family situation allowed clinicians to account for social and emotional contexts. The principal responses to the challenges of

  18. HIV-related knowledge and perceptions by academic major: Implications for university interventions

    Directory of Open Access Journals (Sweden)

    Matthew Lee Smith

    2014-03-01

    Full Text Available Most universities offer human sexuality courses, although they are not required for graduation. While students in health-related majors may receive sexuality education in formal settings, majority of college students never receive formal sexual health or HIV/AIDS-related education, which may lead to elevated engagement in high-risk sexual behaviors. This study examines perceived knowledge about HIV/AIDS, perceived risk, and perceived consequences among college students by two distinct classifications of academic majors. Data were collected from 510 college students. Binary and multinomial logistic regressions were performed to compare HIV-related covariates by academic major category. Limited differences were observed by Science, Technology, Engineering, and Mathematics (STEM categorization. Relative to health and kinesiology (HK majors, those who self-reported being completely knowledgeable about HIV were less likely to be physical sciences, math, engineering, business (PMEB [OR=0.41, P=0.047] or education, humanities, and social sciences (EHS majors [OR=0.25, P=0.004]. PMEB majors were less likely to report behavioral factors as a risk for contracting HIV [OR=0.86, P=0.004] and perceived acquiring HIV would be more detrimental to their quality of life [OR=2.14, P=0.012], but less detrimental to their mental wellbeing [OR=0.58, P=0.042]. Findings can inform college-wide campaigns and interventions to raise HIV/AIDS awareness and improve college health.

  19. Current Problems of Trade Union-Party Relations in Switzerland: Reorientation Versus Inertia

    Science.gov (United States)

    Siegenthaler, Jurg K.

    1975-01-01

    The postwar realignment of union-party relations in Switzerland severed old formal ties but left some important links undisturbed; practical and effective cooperation on legislative items supports current informal union-party alliances. Major current problems include the unions' demand for codetermination in industry and the huge numbers of…

  20. The dispersion relation of charge and current compensated relativistic electron beam-plasma system

    International Nuclear Information System (INIS)

    Vrba, P.; Schroetter, J.; Jarosova, P.; Koerbel, S.

    1978-01-01

    The unstable regions of relativistic electron beam-plasma system were determined by analysing the general dispersion relation numerically. The external parameters were varied to ensure more effective instability excitations. The full charge- and current compensation presumptions lead to the new synchronism predictions. The slow space charge wave and slow cyclotron wave of the return current are synchronous with the plasma ion wave. (author)