FIRE! A Red Flag Tap in Reclaiming Intervention

Science.gov (United States)

Bodnar, Brian

2007-01-01

"Red Flag Interventions" address problems which are imported from elsewhere and acted out towards persons who are in effect innocent bystanders. This is commonly seen as students "carry in" problems from the home or street to school, or they "carry over" conflicts from one class to the next. A third variation of Red Flag intervention is when a…

Experimental investigation of flow field around the elastic flag flapping in periodic state

Science.gov (United States)

Jia, Yongxia; Jia, Lichao; Su, Zhuang; Yuan, Huijing

2018-05-01

The flapping of a flag in the wind is a classical fluid-structure problem that concerns the interaction of elastic bodies with ambient fluid. We focus on the desirable experimental results of the flow around the flapping flag. By immersing the elastic yet self-supporting heavy flag into water flow, we use particle image velocimetry (PIV) techniques to obtain the whole flow field around the midspan of the flag interacting with a fluid in periodic state. A unique PIV image processing method is used to measure near-wall flow velocities around a moving elastic flag. There exists a thin flow circulation region on the suction side of the flag in periodic state. This observation suggests that viscous flow models may be needed to improve the theoretical predictions of the flapping flag in periodic state, especially in a large amplitude.

The Savannah River Site's Groundwater Monitoring Program: Fourth quarter 1991

Energy Technology Data Exchange (ETDEWEB)

Rogers, C.D. (Westinghouse Savannah River Co., Aiken, SC (United States))

1992-06-02

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site's (SRS) Groundwater Monitoring Program. During fourth quarter 1991, EPD/EMS conducted extensive sampling of monitoring wells. EPD/EMS established two sets of criteria in 1986 to assist in the management of sample results. The flagging criteria do not define contamination levels; instead, they aid personnel in sample scheduling, interpretation of data, and trend identification. Beginning in 1991, the flagging criteria are based on EPA drinking water standards and method detection limits. A detailed explanation of the current flagging criteria is presented in the Flagging Criteria section of this document. Analytical results from fourth quarter 1991 are listed in this report.

The Savannah River Site`s Groundwater Monitoring Program: Fourth quarter 1991

Energy Technology Data Exchange (ETDEWEB)

Rogers, C.D. [Westinghouse Savannah River Co., Aiken, SC (United States)

1992-06-02

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site`s (SRS) Groundwater Monitoring Program. During fourth quarter 1991, EPD/EMS conducted extensive sampling of monitoring wells. EPD/EMS established two sets of criteria in 1986 to assist in the management of sample results. The flagging criteria do not define contamination levels; instead, they aid personnel in sample scheduling, interpretation of data, and trend identification. Beginning in 1991, the flagging criteria are based on EPA drinking water standards and method detection limits. A detailed explanation of the current flagging criteria is presented in the Flagging Criteria section of this document. Analytical results from fourth quarter 1991 are listed in this report.

The Savannah River Site`s Groundwater Monitoring Program: Second quarter 1992

Energy Technology Data Exchange (ETDEWEB)

Rogers, C.D. [Westinghouse Savannah River Co., Aiken, SC (United States)

1992-10-07

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site`s (SRS) Groundwater Monitoring Program. During second quarter 1992, EPD/EMS conducted extensive sampling of monitoring wells. EPD/EMS established two sets of criteria to assist in the management of sample results. The flagging criteria do not define contamination levels; instead, they aid personnel in sample scheduling, interpretation of data, and trend identification. Since 1991, the flagging criteria have been based on the federal Environmental Protection Agency (EPA) drinking water standards and on method detection limits. A detailed explanation of the current flagging criteria is presented in the Flagging Criteria section of this document. Analytical results from second quarter 1992 are listed in this report.

A Rotational Crofton Formula for Flagged Intrinsic Volumes of Sets of Positive Reach

DEFF Research Database (Denmark)

Auneau, Jeremy Michel

A rotational Crofton formula is derived relating the flagged intrinsic volumes of a compact set of positive reach with the flagged intrinsic volumes measured on sections passing through a fixed point. In particular cases, the flagged intrinsic volumes defined in the present paper are identical...

Support for the Confederate Battle Flag in the Southern United States: Racism or Southern Pride?

Directory of Open Access Journals (Sweden)

Joshua D. Wright

2017-05-01

Full Text Available Supporters of the Confederate battle flag often argue that their support is driven by pride in the South, not negative racial attitudes. Opponents of the Confederate battle flag often argue that the flag represents racism, and that support for the flag is an expression of racism and an attempt to maintain oppression of Blacks in the Southern United States. We evaluate these two competing views in explaining attitudes toward the Confederate battle flag in the Southern United States through a survey of 526 Southerners. In the aggregate, our latent variable model suggests that White support for the flag is driven by Southern pride, political conservatism, and blatant negative racial attitudes toward Blacks. Using cluster-analysis we were able to distinguish four distinct sub-groups of White Southerners: Cosmopolitans, New Southerners, Traditionalists, and Supremacists. The greatest support for the Confederate battle flag is seen among Traditionalists and Supremacists; however, Traditionalists do not display blatant negative racial attitudes toward Blacks, while Supremacists do. Traditionalists make up the majority of Confederate battle flag supporters in our sample, weakening the claim that supporters of the flag are generally being driven by negative racial attitudes toward Blacks.

Exposure to the American flag polarizes democratic-republican ideologies.

Science.gov (United States)

Chan, Eugene Y

2017-12-01

Some prior research has suggested that exposure to the American flag tilts Americans towards Republicanism, while others have proffered that it brings outs a common 'together' perspective instead. We explore a third possibility - that it may actually polarize Americans' political ideology. It is generally accepted that exposure to an environmental cue can shift attitudes and behaviours, at least partly or temporarily, in a manner that is consistent with that cue. Yet, the same cue can mean different things to different people. In the same vein, given how national identity and political ideology are intertwined in the United States, we hypothesize that the American flag should heighten different political beliefs depending on individuals' political ideology. To Democrats, being American is to support Democratic values, but to Republicans, being American is to support Republican values. The American flag thus should heighten Democrats of their Democratic identity, and it should heighten Republicans of their Republican one. The results of an experiment with 752 American respondents who were representative of the US population supported this polarizing effect of the American flag. The theoretical and policy implications of the findings are offered. © 2017 The British Psychological Society.

The Savannah River Site's Groundwater Monitoring Program: Second quarter 1992

Energy Technology Data Exchange (ETDEWEB)

Rogers, C.D. (Westinghouse Savannah River Co., Aiken, SC (United States))

1992-10-07

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site's (SRS) Groundwater Monitoring Program. During second quarter 1992, EPD/EMS conducted extensive sampling of monitoring wells. EPD/EMS established two sets of criteria to assist in the management of sample results. The flagging criteria do not define contamination levels; instead, they aid personnel in sample scheduling, interpretation of data, and trend identification. Since 1991, the flagging criteria have been based on the federal Environmental Protection Agency (EPA) drinking water standards and on method detection limits. A detailed explanation of the current flagging criteria is presented in the Flagging Criteria section of this document. Analytical results from second quarter 1992 are listed in this report.

Flags of the night sky when astronomy meets national pride

CERN Document Server

Bordeleau, André G

2014-01-01

Many national flags display astronomical features–Sun, Moon, stars–but are they really based on existing astronomical objects? The United States flag sports 50 stars, one for each state, however none of them are linked to real stars. Further, the lunar crescent is often shaped like the Sun being eclipsed by the Moon. At times, stars are seen right next to the crescent, where the darkened disc of the moon should be! This book will present true astronomical objects and patterns highlighted on national flags and link informative capsules about these objects to the political reasons why they were chosen to adorn such an important symbol.

Current ecological research towards completion criteria in Queensland

Energy Technology Data Exchange (ETDEWEB)

Grigg, A.; Mulligan, D.; Bellairs, S.; Harwood, M. [University of Queensland, St. Lucia, Qld. (Australia). Centre for Mined Land Rehabilitation

1998-12-31

There is a growing recognition of the need for criteria to determine when rehabilitation is successful or complete. Moreover, with the current emphasis on sustainability, criteria need to embrace a range of ecological attributes which in turn require an understanding of the ecosystems being created. This paper describes current research by the Centre for Mined Land Rehabilitation on ecosystem development at a number of operations throughout Queensland in the a bauxite, heavy mineral sands, gold and coal mining sectors. Case studies are presented which cover a number of ecological processes including nutrient cycling, vegetation succession and seedling recruitment. They are based in a range of different environments and encompass several different proposed end land uses. The paper demonstrates the utility of an hierarchical approach in assessing rehabilitation success, and that different elements within the hierarchy have differing levels of importance depending on specific minesite conditions. 22 refs., 3 figs.

High explosive programmed burn in the FLAG code

Energy Technology Data Exchange (ETDEWEB)

Mandell, D.; Burton, D.; Lund, C.

1998-02-01

The models used to calculate the programmed burn high-explosive lighting times for two- and three-dimensions in the FLAG code are described. FLAG uses an unstructured polyhedra grid. The calculations were compared to exact solutions for a square in two dimensions and for a cube in three dimensions. The maximum error was 3.95 percent in two dimensions and 4.84 percent in three dimensions. The high explosive lighting time model described has the advantage that only one cell at a time needs to be considered.

76 FR 39885 - Risk-Based Targeting of Foreign Flagged Mobile Offshore Drilling Units (MODUs)

Science.gov (United States)

2011-07-07

... Foreign Flagged Mobile Offshore Drilling Units (MODUs) AGENCY: Coast Guard, DHS. ACTION: Notice of... 11-06, Risk-Based Targeting of Foreign Flagged Mobile Offshore Drilling Units (MODUs). This policy... applicable regulations, every foreign-flagged mobile offshore drilling unit (MODU) must undergo a Coast Guard...

Artist's rendering of astronaut Neil Armstrong planting U.S. flag on Moon

Science.gov (United States)

1969-01-01

Artist's Concept: Apollo 11 astronaut Neil Armstrong, after stepping onto the lunar surface, will plant the United States flag in its soil. The flag will be made of nylone, size 3- by 5 feet on a staff 8 feet long. During flight it will be stowed in two 4-foot sections strapped to the Lunar Module ladder. Armstrong's first assignment after stepping off the ladder is to pull a 'D' ring to start a television camera. The second assignment is to erect the U.S. flag. The flag will appear to be flying in a breeze. This is done with a spring-loaded wire in the nylon cloth. With everything is working normally, this will be observed on live television.

Potential synergy between the Ionospheric Disturbance Flag and NeQuick-G for single frequency users

Science.gov (United States)

Aragon-Angel, Angela; Fortuny, Joaquim

2016-04-01

The document describing the particular ionospheric model developed for the Galileo satellite navigation system has been very recently released, the official Ionospheric Correction Algorithm for Galileo Single Frequency Users document (from here on-wards named Galileo-Iono), available at www.gsc-europa.eu/system/files/galileo_documents/Galileo_Ionospheric_Model.pdf. This publication allows GNSS receiver manufacturers to start the implementation of the specific algorithm targeted for their Galileo related products in order to be compliant with the Galileo system. As indicated in the Galileo OS SIS ICD, among the parameters that are broadcast in the Galileo navigation message, parameters that are sent within both F/NAV and I/NAV, one can find five Ionospheric Disturbance Flags for Regions 1 to 5 (SF1, SF2, SF3, SF4 and SF5). Nevertheless, in the current version of the model presented in the Galileo-Iono document, the Ionospheric Disturbance flags are "not used" within the Galileo ionospheric correction calculation. In this work, a potential approach to account for this information is being investigated. This plan includes the update of the Galileo ionospheric, NeQuick-G, correction model by specifying the use of these flags. Hence a customized version of the NeQuick-G model has been developed and tested. Specific scenarios will be considered to test whether this approach of considering the added value information of the Ionospheric Disturbance Flags is translated into the positioning domain. In order to assess the improvement obtained using the proposed approach five stations displaced in the five regions are used. Different days of data have been collected in nominal and disturbed conditions; the evaluation is carried out comparing the performance of the proposed approach with respect to the classical approach. The benefits of the use of the disturbance flags information are evaluated comparing the performance in similar geometry conditions.

Pseudo-Kaehler quantization on flag manifolds

International Nuclear Information System (INIS)

Karabegov, A.V.

1997-07-01

A unified approach to geometric, symbol and deformation quantizations on a generalized flag manifold endowed with an invariant pseudo-Kaehler structure is proposed. In particular cases we arrive at Berezin's quantization via covariant and contravariant symbols. (author). 16 refs

The iconography of the flags of Charles V: examples and documents

Directory of Open Access Journals (Sweden)

Jesús F. Pascual Molina

2017-03-01

Full Text Available The Emperor Charles V formed an important group of arms and armor in his armory at Valladolid. In 1556, during his last journey to Spain, new pieces were sent to this royal armory; after his death they passed to Philip II, who sent them to Madrid, where he ordered a new building especially for the collection. Among these pieces was an important group of flags linked to major episodes of the Emperor’s life. The author describes the flags and their iconography, providing as well unpublished archival materials, which permit a better understanding of the flags used in times of Caesar Charles and their meanings.

Cyber Flag: A Realistic Cyberspace Training Construct

National Research Council Canada - National Science Library

Hansen, Andrew P

2008-01-01

.... Red Flag provides dominant training within the air domain and now with the evolution of cyberspace, a comprehensive training environment is necessary to meet this growing and broadening threat...

FlagHouse Forum: You Say "Tomato"... and I Use a Communicator

Science.gov (United States)

Exceptional Parent, 2011

2011-01-01

This month's "FlagHouse Forum" focuses on how to choose the communicator best-suited to a child's special need. FlagHouse--a premier global supplier of resources for special needs, education, physical activity and recreation--is pleased to partner with "Exceptional Parent" to bring its readers this informational forum. Humans communicate with each…

Anomalous Hydrodynamic Drafting of Interacting Flapping Flags

Science.gov (United States)

Ristroph, Leif; Zhang, Jun

2008-11-01

In aggregates of objects moving through a fluid, bodies downstream of a leader generally experience reduced drag force. This conventional drafting holds for objects of fixed shape, but interactions of deformable bodies in a flow are poorly understood, as in schools of fish. In our experiments on “schooling” flapping flags, we find that it is the leader of a group who enjoys a significant drag reduction (of up to 50%), while the downstream flag suffers a drag increase. This counterintuitive inverted drag relationship is rationalized by dissecting the mutual influence of shape and flow in determining drag. Inverted drafting has never been observed with rigid bodies, apparently due to the inability to deform in response to the altered flow field of neighbors.

46 CFR 252.22 - Substantiality and extent of foreign-flag competition.

Science.gov (United States)

2010-10-01

... January 1 of the subsidized year, by surveying a data file known as “Merchant Fleets of the World” that is... total tonnage in the range. (e) Largest foreign flag not competitor. In the event that the Board... competitor of any particular operator, the Board may determine the foreign-flag competition in a manner that...

Yellow flag scores in a compensable New Zealand cohort suffering acute low back pain

Directory of Open Access Journals (Sweden)

Karen Grimmer-Somers

2008-12-01

Full Text Available Karen Grimmer-Somers1, Mathew Prior1, Jim Robertson21Centre for Allied Health Evidence, University of South Australia, City East Campus, North Tce, Adelaide, South Australia, Australia; 2New Zealand Accident Compensation Corporation, Auckland, New ZealandBackground: Despite its high prevalence, most acute low back pain (ALBP is nonspecific, self-limiting with no definable pathology. Recurrence is prevalent, as is resultant chronicity. Psychosocial factors (yellow flags comprising depression and anxiety, negative pain beliefs, job dissatisfaction are associated with the development of chronic LBP.Methods: A national insurer (Accident Compensation Corporation, New Zealand [NZ], in conjunction with a NZ primary health organization, piloted a strategy for more effective management of patients with ALBP, by following the NZ ALBP Guideline. The guidelines recommend the use of a psychosocial screening instrument (Yellow Flags Screening Instrument, a derivative of Örebro Musculoskeletal Pain Questionnaire. This instrument was recommended for administration on the second visit to a general medical practitioner (GP. This paper tests whether published cut-points of yellow flag scores to predict LBP claims length and costs were valid in this cohort.Results: Data was available for 902 claimants appropriately enrolled into the pilot. 25% claimants consulted the GP once only, and thus were not requested to provide a yellow flag score. Yellow flag scores were provided by 48% claimants who consumed two or more GP services. Approximately 60% LBP presentations resolved within five GP visits. Yellow flag scores were significantly and positively associated with treatment costs and service use, although the association was nonlinear. Claimants with moderate yellow flag scores were similarly likely to incur lengthy claims as claimants with at-risk scores.Discussion: Capturing data on psychosocial factors for compensable patients with ALBP has merit in predicting

Effects of Cd2+ on chlorophyll content in flag and grain yield of wheats

International Nuclear Information System (INIS)

Zhu Zhiyong; Li Youjun; Liu Yingjie; Duan Youqiang; Li Qiang; Hao Yufen; Guo Jia

2011-01-01

A field experiment was conducted with wheat cultivars Luohan 6 and Yumai 18 to investigate the effects of Cd 2+ stress on chlorophyll contents in flag leaves, flag leave area, thousand kernel weight, kernel filling velocity and yield of wheat. Results indicated that, under low Cd 2+ stress (10 mg/kg), the average contents of chlorophyll a + b of Luohan 6 reduced by 1.6%, however, its average area of flag leave and yield increased by 3.8% and 1.6%, respectively. At the same time, the average content of chlorophyll a + b, area of flag leave yield of Yumai 18 reduced 8.0%, 9.6% and 5.4%. Under high Cd 2+ stress (100 mg/kg), the average contents of chlorophyll a + b, areas of flag leaves and yields of Luohan 6 and Yumai 18 reduced by 29.2% and 30.5%, 6.3% and 17.4%, 16.7% and 36.7%, respectively. The results demonstrated that Cd 2+ restrained synthesis and accumulation of chlorophyll and its components. This study even showed that within a range of Cd 2+ concentration could promote the growth of flag leaves, and it also had an equal positive effect on yield of wheat if the Cd 2+ concentration in grains were not out of limit. The growth of flag leave and yield of wheat would be limited when Cd 2+ concentration exceed that range. Overall, Yumai 18 bore more poison from Cd 2+ than Luohan 6. (authors)

Pseudo-Kähler Quantization on Flag Manifolds

Science.gov (United States)

Karabegov, Alexander V.

A unified approach to geometric, symbol and deformation quantizations on a generalized flag manifold endowed with an invariant pseudo-Kähler structure is proposed. In particular cases we arrive at Berezin's quantization via covariant and contravariant symbols.

The Full Kostant-Toda Hierarchy on the Positive Flag Variety

Science.gov (United States)

Kodama, Yuji; Williams, Lauren

2015-04-01

We study some geometric and combinatorial aspects of the solution to the full Kostant-Toda (f-KT) hierarchy, when the initial data is given by an arbitrary point on the totally non-negative (tnn) flag variety of . The f-KT flows on the tnn flag variety are complete, and we show that their asymptotics are completely determined by the cell decomposition of the tnn flag variety given by Rietsch (Total positivity and real flag varieties. Ph.D. Thesis, Massachusetts Institute of Technology, Cambridge, 1998). Our results represent the first results on the asymptotics of the f-KT hierarchy (and even the f-KT lattice); moreover, our results are not confined to the generic flow, but cover non-generic flows as well. We define the f-KT flow on the weight space via the moment map, and show that the closure of each f-KT flow forms an interesting convex polytope which we call a Bruhat interval polytope. In particular, the Bruhat interval polytope for the generic flow is the permutohedron of the symmetric group . We also prove analogous results for the full symmetric Toda hierarchy, by mapping our f-KT solutions to those of the full symmetric Toda hierarchy. In the appendix we show that Bruhat interval polytopes are generalized permutohedra, in the sense of Postnikov (Int. Math. Res. Not. IMRN (6):1026-1106, 2009).

Swedish Seafarers' Commitment to Work in Times of Flagging out

Directory of Open Access Journals (Sweden)

C. Hult

2014-03-01

Full Text Available This study takes its departure in the difficulties to recruit and retain qualified senior seafarers in the Swedish shipping sector. The study focus is on seafarers' motivation at work for the specific shipping company (organizational commitment, and seafarers' motivation towards their occupation (occupational commitment, in times of flagging out. It was hypothesized that the youngest seafarers and the oldest may be most sensitive to foreign registration of ships. Statistical analyses were employed, using a survey material of 1,309 Swedish seafarers randomly collected in 2010 from a national register of seafarers. The results of the analyses show that flagging-out imposes a significant decline in organizational commitment for all seafarers. This decline is related to the perception of the social composition of crew. In addition, the oldest seafarers (age 55+ demonstrate diminished occupational commitment under a foreign flag. This decline is related to the degree of satisfaction with the social security structure. Occupational commitment among the youngest seafarers (age 19-30 is not affected by the nationality of flag. However, this type of commitment is decreasing by the time served on the same ship. This effect is partly related to a decline in satisfaction with the work content. In the concluding discussion, the findings are discussed in more details and recommendations are put forward.

Using atypical symptoms and red flags to identify non-demyelinating disease.

LENUS (Irish Health Repository)

Kelly, Siobhan B

2012-01-01

Red flags and atypical symptoms have been described as being useful in suggesting alternative diagnoses to multiple sclerosis (MS) and clinically isolated syndrome (CIS); however, their diagnostic utility has not been assessed. The aim of this study was to establish the predictive value of red flags and the typicality\\/atypicality of symptoms at presentation in relation to the final diagnosis of patients referred with suspected MS.

Frobenius splitting of thick flag manifolds of Kac-Moody algebras

OpenAIRE

Kato, Syu

2017-01-01

We explain that the Pl\\"ucker relations provide the defining equations of the thick flag manifold associated to a Kac-Moody algebra. This naturally transplant the result of Kumar-Mathieu-Schwede about the Frobenius splitting of thin flag manifolds to the thick case. As a consequence, we provide a description of the global sections of line bundles of a thick Schubert variety as conjectured in Kashiwara-Shimozono [Duke Math. J. 148 (2009)]. This also yields the existence of a compatible basis o...

Red flags in detecting credit cooperative fraud: the perceptions of internal auditors

Directory of Open Access Journals (Sweden)

Cristian Baú Dal Magro

2017-07-01

Full Text Available Purpose – Red flags are mechanisms that can be used by internal auditors for early detection of possible fraud. In this context, the aim of this study was to identify the relevance credit unions’ internal auditors attribute to red flags in assessing fraud risk. Design/methodology/approach – This article is characterized as descriptive concerning its goals, as a survey as to is procedures, and as quantitative in reference to its approach to the problem. The sample onsists of 51 internal auditors working in Credit Union Centers in southern Brazil. Findings – Results indicate that, in the assessment of fraud risk, internal auditors attribute greater importance to red flags referring to operational activities and internal control procedures. In addition, it is suggested that internal auditors are not impartial concerning their perception of relevance of most of the warning signs of the possibility of fraud. Originality/value – The findings contribute by demonstrating to internal auditors the need for greater attention to the use of red flags as auditing tools.

Evidence for current diagnostic criteria of diabetes mellitus

Institute of Scientific and Technical Information of China (English)

Ritesh; Kumar[1; Lakshmana; Perumal; Nandhini[1; Sadishkumar; Kamalanathan[1; Jayaprakash; Sahoo[1; Muthupillai; Vivekanadan[1

2016-01-01

Diabetes mellitus is a non-communicable metabolic derangement afflicting several millions of individuals globally. It is associated with several micro and macrovascular complications and is also a leading cause of mortality. The unresolved issue is that of definition of the diagnostic threshold for diabetes. The World Health Organization and the American Diabetes Association (ADA) have laid down several diagnostic criteria for diagnosing diabetes and prediabetes based on the accumulating body of evidence.This review has attempted to analyse the scientific evidence supporting the justification of these differing criteria. The evidence for diagnosing diabetes is strong, and there is a concordance between the two professional bodies.The controversy arises when describing the normal lower limit of fasting plasma glucose (FPG) with little evidence favouring the reduction of the FPG by the ADA. Several studies have also shown the development of complications specific for diabetes in patients with prediabetes as defined by the current criteria though there is a significant overlap of such prevalence in individuals with normoglycemia. Large multinational longitudinal prospective studies involving subjects without diabetes and retinopathy at baseline will ideally help identify the threshold of glycemic measurements for future development of diabetes and its complications.

Decommissioning of nuclear facilities using current criteria

International Nuclear Information System (INIS)

Shum, E.Y.; Swift, J.J.; Malaro, J.C.

1991-01-01

When a licensed nuclear facility ceases operation, the US Nuclear Regulatory Commission (NRC) is responsible for ensuring that the facility and its site are decontaminated to an acceptable level so that it is safe to release that facility and site for unrestricted public use. Currently, the NRC is developing decommissioning criteria based on reducing public doses from residual contamination in soils and structures at sites released for unrestricted use to as low as is reasonably achievable (ALARA). Plans are to quantify ALARA in terms of an annual total effective dose equivalent (TEDE) to an average member of the most highly exposed population group. The NRC is working on a regulatory guidance document to provide a technical basis for translating residual contamination levels to annual dose levels. Another regulatory guide is being developed to provide guidance to the licensee on how to conduct radiological surveys to demonstration compliance with the NRC decommissioning criteria. The methods and approaches used in these regulatory guides on the decommissioning of a nuclear facility are discussed in the paper

75 FR 66125 - Federal Land Managers' Air Quality Related Values Work Group (FLAG)

Science.gov (United States)

2010-10-27

... pollutants that could affect the health and status of resources in areas managed by the three agencies... Work Group (FLAG) AGENCY: National Park Service, Interior. ACTION: Notice of availability of final... Public Comments document. The Federal Land Managers' Air Quality Related Values Work Group (FLAG) was...

Navigating recurrent abdominal pain through clinical clues, red flags, and initial testing.

Science.gov (United States)

Noe, Joshua D; Li, B U K

2009-05-01

Recurrent abdominal pain is a common chronic complaint that presents to your office. The constant challenge is one of detecting those with organic disease from the majority who have a functional pain disorder including functional dyspepsia, irritable bowel syndrome, functional abdominal pain, and abdominal migraine. Beginning with a detailed history and physical exam, you can: 1) apply the symptom-based Rome III criteria to positively identify a functional disorder, and 2) filter these findings through the diagnostic clues and red flags that point toward specific organic disease and/or further testing. Once a functional diagnosis has been made or an organic disease is suspected, you can initiate a self-limited empiric therapeutic trial. With this diagnostic approach, you should feel confident navigating through the initial evaluation, management, and consultation referral for a child or adolescent with recurrent abdominal pain.

Developing an early alert system for metastatic spinal cord compression (MSCC): Red Flag credit cards.

Science.gov (United States)

Turnpenney, Jackie; Greenhalgh, Sue; Richards, Lena; Crabtree, Annamaria; Selfe, James

2015-01-01

To produce a user-friendly list of metastatic spinal cord compression (MSCC) Red Flags for non-specialist 'generalist' front-line clinicians working in primary-care settings. The issue of identifying MSCC early to prevent serious long-term disability was a key theme identified by the Task and Finish Group at Greater Manchester and Cheshire Cancer Network (GMCCN) in 2009. It was this group who initially brokered and then coordinated the current development as part of their strategic approach to improving care for MSCC patients. A consensus-building approach that considered the essential minimum data requirements to raise the index of suspicion suggestive of MSCC was adopted. This followed a model of cross-boundary working to facilitate the mutual sharing of expertise across a variety of relevant clinical specialisms. A guideline aimed at helping clinicians to identify the early signs and symptoms of MSCC was produced in the form of a credit card. This credit card includes key statements about MSCC, signposting to key sources of additional information and a user-friendly list of Red Flags which has been developed into an eight-item Red Flag mnemonic. To date, an excess of 120,000 cards have been printed by a variety of organisations and the distribution of the cards is ongoing across the United Kingdom and the Republic of Ireland.

Reliance communications' flag telecom to provide ethernet link between CERN and TIFR

CERN Multimedia

2007-01-01

"Flag Telecom Group Limited (Flag), the undersea cable network arm of Anil Ambani-le Reliance Communications, has announced a landmark deal with CERn (Conseil Européen pour la Recheche Nucléaire), the European organisation for nuclear research based in Geneva, Switzerland and the Tata institute of Fundamental Research (TIFR) in Mumbai to provide gigabit Ethernet connectivity between the two." (1 page)

An algorithm for applying flagged Sysmex XE-2100 absolute neutrophil counts in clinical practice

DEFF Research Database (Denmark)

Friis-Hansen, Lennart; Saelsen, Lone; Abildstrøm, Steen Z

2008-01-01

BACKGROUND: Even though most differential leukocyte counts are performed by automated hematology platforms, turn-around time is often prolonged as flagging of test results trigger additional confirmatory manual procedures. However, frequently only the absolute neutrophil count (ANC) is needed. We...... therefore examined if an algorithm could be developed to identify samples in which the automated ANC is valid despite flagged test results. METHODS: During a 3-wk period, a training set consisting of 1448 consecutive flagged test-results from the Sysmex XE-2100 system and associated manual differential...... counts was collected. The training set was used to determine which alarms were associated with valid ANCs. The algorithm was then tested on a new set of 1371 test results collected during a later 3-wk period. RESULTS: Analysis of the training set data revealed that the ANC from test results flagged...

Testing ALE code FLAG with analytical self-similar solutions of 2D magnetized implosion

Energy Technology Data Exchange (ETDEWEB)

Bereznyak, Andrey [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gianakon, Thomas Arthur [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rousculp, Christopher L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cooley, James Hamilton [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Giuliani, John [Naval Research Lab. (NRL), Washington, DC (United States)

2018-01-04

The goal of this collaboration was to provide a mechanism to verify the MHD implementation in FLAG and improve the FLAG MHD packages as need to meet broader LANL institutional goals. These three Magnetic Noh problems are proving immensely useful.

Clinicians' perspective of the current diagnostic criteria for myofascial pain syndrome.

Science.gov (United States)

Grosman-Rimon, Liza; Clarke, Hance; Chan, Aaron K; Mills, Patricia Branco; Rathbone, Alasdair Timothy Llewelyn; Kumbhare, Dinesh

2017-01-01

Myofascial pain syndrome (MPS) is one of the most common chronic musculoskeletal pain disorders. However, MPS is often under-diagnosed. The purpose of this study was to characterize practicing clinicians' perspectives of the current diagnostic criteria for MPS. A cross-sectional study design was used with a self-administered questionnaire. The questionnaire evaluated clinicians' perspective of the current diagnostic criteria for MPS. The sample population (n= 119) consisted of 40% family physicians, 31% physical medicine (PM) and rehabilitation specialists, 11% rheumatologists, 10% emergency room (ER) physicians, and 8% anesthesiologists specializing in chronic pain. Our findings demonstrated that participating clinicians agree that ``point tenderness'' and ``pain reproduction'' are criteria for MPS. In contrast, the clinicians do not consider ``autonomic symptoms'' as an important criterion for MPS. The anesthesiologists view ``restricted range of motion'' as a criterion for MPS more than the other groups, and they tend to consider ``referred pain'' and ``pain reproduction'' as criteria. Physical medicine and rehabilitation specialists and anesthesiologists tend to view ``local twitch response'' more as a criterion for MPS compared with the other groups. Most groups of clinicians consider ``weakness without atrophy'' as an important MPS criterion except for family physicians. It is important to note that ``poor sleep'', ``daytime fatigue'' and ``cognitive symptoms'', which are not considered as MPS symptoms, are often mistaken for MPS among practicing clinicians. Our findings suggest that the diagnostic criteria are not well known, highlighting the need for an expert consensus to determine the importance of each criterion for MPS diagnosis.

Customization of Advia 120 thresholds for canine erythrocyte volume and hemoglobin concentration, and effects on morphology flagging results.

Science.gov (United States)

Grimes, Carolyn N; Fry, Michael M

2014-12-01

This study sought to develop customized morphology flagging thresholds for canine erythrocyte volume and hemoglobin concentration [Hgb] on the ADVIA 120 hematology analyzer; compare automated morphology flagging with results of microscopic blood smear evaluation; and examine effects of customized thresholds on morphology flagging results. Customized thresholds were determined using data from 52 clinically healthy dogs. Blood smear evaluation and automated morphology flagging results were correlated with mean cell volume (MCV) and cellular hemoglobin concentration mean (CHCM) in 26 dogs. Customized thresholds were applied retroactively to complete blood (cell) count (CBC) data from 5 groups of dogs, including a reference sample group, clinical cases, and animals with experimentally induced iron deficiency anemia. Automated morphology flagging correlated more highly with MCV or CHCM than did blood smear evaluation; correlation with MCV was highest using customized thresholds. Customized morphology flagging thresholds resulted in more sensitive detection of microcytosis, macrocytosis, and hypochromasia than default thresholds.

Flag-dipole and flagpole spinor fluid flows in Kerr spacetimes

Energy Technology Data Exchange (ETDEWEB)

Rocha, Roldão da, E-mail: roldao.rocha@ufabc.edu.br [Universidade Federal do ABC, CMCC (Brazil); Cavalcanti, R. T., E-mail: rogerio.cavalcanti@ufabc.edu.br [Universidade Federal do ABC, CCNH (Brazil)

2017-03-15

Flagpole and flag-dipole spinors are particular classes of spinor fields that has been recently used in different branches of theoretical physics. In this paper, we study the possibility and consequences of these spinor fields to induce an underlying fluid flow structure in the background of Kerr spacetimes. We show that flag-dipole spinor fields are solutions of the equations of motion in this context. To our knowledge, this is the second time that this class of spinor field appears as a physical solution, the first one occurring as a solution of the Dirac equation in ESK gravities.

Sensitivity of the International Skating Union's Mathematical Criteria to Flag Potential Scoring Anomalies

Science.gov (United States)

Looney, Marilyn A.; Howell, Steven M.

2015-01-01

This article describes the "mathematical criteria" employed by the International Skating Union (ISU) to identify potential judging anomalies within competitive figure skating. The mathematical criteria have greater sensitivity to identify scoring anomalies for technical element scores than for the program component scores. This article…

Phloem Transport of Arsenic Species from Flag Leaf to Grain During Grain Filling

Energy Technology Data Exchange (ETDEWEB)

A Carey; G Norton; C Deacon; K Scheckel; E Lombi; T Punshon; M Guerinot; A Lanzirotti; M Newville; et al.

2011-12-31

Strategies to reduce arsenic (As) in rice grain, below concentrations that represent a serious human health concern, require that the mechanisms of As accumulation within grain be established. Therefore, retranslocation of As species from flag leaves into filling rice grain was investigated. Arsenic species were delivered through cut flag leaves during grain fill. Spatial unloading within grains was investigated using synchrotron X-ray fluorescence (SXRF) microtomography. Additionally, the effect of germanic acid (a silicic acid analog) on grain As accumulation in arsenite-treated panicles was examined. Dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) were extremely efficiently retranslocated from flag leaves to rice grain; arsenate was poorly retranslocated, and was rapidly reduced to arsenite within flag leaves; arsenite displayed no retranslocation. Within grains, DMA rapidly dispersed while MMA and inorganic As remained close to the entry point. Germanic acid addition did not affect grain As in arsenite-treated panicles. Three-dimensional SXRF microtomography gave further information on arsenite localization in the ovular vascular trace (OVT) of rice grains. These results demonstrate that inorganic As is poorly remobilized, while organic species are readily remobilized, from leaves to grain. Stem translocation of inorganic As may not rely solely on silicic acid transporters.

Phloem transport of arsenic species from flag leaf to grain during grain filling

Energy Technology Data Exchange (ETDEWEB)

Carey, Anne-Marie; Norton, Gareth J.; Deacon, Claire; Scheckel, Kirk G.; Lombi, Enzo; Punshon, Tracy; Guerinot, Mary Lou; Lanzirotti, Antonio; Newville, Matt; Choi, Yongseong; Price, Adam H.; Meharg, Andrew A. (EPA); (U. South Australia); (Aberdeen); (UC); (Dartmouth)

2011-09-20

Strategies to reduce arsenic (As) in rice grain, below concentrations that represent a serious human health concern, require that the mechanisms of As accumulation within grain be established. Therefore, retranslocation of As species from flag leaves into filling rice grain was investigated. Arsenic species were delivered through cut flag leaves during grain fill. Spatial unloading within grains was investigated using synchrotron X-ray fluorescence (SXRF) microtomography. Additionally, the effect of germanic acid (a silicic acid analog) on grain As accumulation in arsenite-treated panicles was examined. Dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) were extremely efficiently retranslocated from flag leaves to rice grain; arsenate was poorly retranslocated, and was rapidly reduced to arsenite within flag leaves; arsenite displayed no retranslocation. Within grains, DMA rapidly dispersed while MMA and inorganic As remained close to the entry point. Germanic acid addition did not affect grain As in arsenite-treated panicles. Three-dimensional SXRF microtomography gave further information on arsenite localization in the ovular vascular trace (OVT) of rice grains. These results demonstrate that inorganic As is poorly remobilized, while organic species are readily remobilized, from leaves to grain. Stem translocation of inorganic As may not rely solely on silicic acid transporters.

Field evidence of social influence in the expression of political preferences: the case of secessionists flags in Barcelona.

Science.gov (United States)

Parravano, Antonio; Noguera, José A; Hermida, Paula; Tena-Sánchez, Jordi

2015-01-01

Models of social influence have explored the dynamics of social contagion, imitation, and diffusion of different types of traits, opinions, and conducts. However, few behavioral data indicating social influence dynamics have been obtained from direct observation in "natural" social contexts. The present research provides that kind of evidence in the case of the public expression of political preferences in the city of Barcelona, where thousands of citizens supporting the secession of Catalonia from Spain have placed a Catalan flag in their balconies and windows. Here we present two different studies. 1) During July 2013 we registered the number of flags in 26% of the electoral districts in the city of Barcelona. We find that there is a large dispersion in the density of flags in districts with similar density of pro-independence voters. However, by comparing the moving average to the global mean we find that the density of flags tends to be fostered in electoral districts where there is a clear majority of pro-independence vote, while it is inhibited in the opposite cases. We also show that the distribution of flags in the observed districts deviates significantly from that of an equivalent random distribution. 2) During 17 days around Catalonia's 2013 national holiday we observed the position at balcony resolution of the flags displayed in the facades of a sub-sample of 82 blocks. We compare the 'clustering index' of flags on the facades observed each day to thousands of equivalent random distributions. Again we provide evidence that successive hangings of flags are not independent events but that a local influence mechanism is favoring their clustering. We also find that except for the national holiday day the density of flags tends to be fostered in facades located in electoral districts where there is a clear majority of pro-independence vote.

The epidemiology of injuries in contact flag football.

Science.gov (United States)

Kaplan, Yonatan; Myklebust, Grethe; Nyska, Meir; Palmanovich, Ezequiel; Victor, Jan; Witvrouw, Erik

2013-01-01

To characterize the epidemiology of injuries in post-high school male and female athletes in the rapidly growing international sport of contact flag football. Prospective injury-observational study. Kraft Stadium, Jerusalem, Israel. A total of 1492 players, consisting of men (n = 1252, mean age, 20.49 ± 5.11) and women (n = 240, mean age, 21.32 ± 8.95 years), participated in 1028 games over a 2-season period (2007-2009). All time-loss injuries sustained in game sessions were recorded by the off-the-field medical personnel and followed up by a more detailed phone injury surveillance questionnaire. One hundred sixty-three injuries were reported, comprising 1 533 776 athletic exposures (AEs). The incidence rate was 0.11 [95% confidence interval (CI), 0.09-0.12] per 1000 AEs, and incidence proportion was 10.66% (95% CI, 9.10-12.22). Seventy-six percent of the injuries were extrinsic in nature. Thirty percent of the injuries were to the fingers, thumb, and wrist, 17% to the knee, 17% to the head/face, 13% to the ankle, and 11% to the shoulder. Contact flag football results in a significant amount of moderate to severe injuries. These data may be used in the development of a formal American flag football injury database and in the development and implementation of a high-quality, randomized, prospective injury prevention study. This study should include the enforcement of the no-pocket rule, appropriate headgear, self-fitting mouth guards, the use of ankle braces, and changing the blocking rules of the game.

Multi-Level Pre-Correlation RFI Flagging for Real-Time Implementation on UniBoard

Science.gov (United States)

Dumez-Viou, Cédric; Weber, Rodolphe; Ravier, Philippe

2016-03-01

Because of the denser active use of the spectrum, and because of radio telescopes higher sensitivity, radio frequency interference (RFI) mitigation has become a sensitive topic for current and future radio telescope designs. Even if quite sophisticated approaches have been proposed in the recent years, the majority of RFI mitigation operational procedures are based on post-correlation corrupted data flagging. Moreover, given the huge amount of data delivered by current and next generation radio telescopes, all these RFI detection procedures have to be at least automatic and, if possible, real-time. In this paper, the implementation of a real-time pre-correlation RFI detection and flagging procedure into generic high-performance computing platforms based on field programmable gate arrays (FPGA) is described, simulated and tested. One of these boards, UniBoard, developed under a Joint Research Activity in the RadioNet FP7 European programme is based on eight FPGAs interconnected by a high speed transceiver mesh. It provides up to 4 TMACs with ®Altera Stratix IV FPGA and 160 Gbps data rate for the input data stream. The proposed concept is to continuously monitor the data quality at different stages in the digital preprocessing pipeline between the antennas and the correlator, at the station level and the core level. In this way, the detectors are applied at stages where different time-frequency resolutions can be achieved and where the interference-to-noise ratio (INR) is maximum right before any dilution of RFI characteristics by subsequent channelizations or signal recombinations. The detection decisions could be linked to a RFI statistics database or could be attached to the data for later stage flagging. Considering the high in-out data rate in the pre-correlation stages, only real-time and go-through detectors (i.e. no iterative processing) can be implemented. In this paper, a real-time and adaptive detection scheme is described. An ongoing case study has been

Generation and characterization of a human-mouse chimeric high-affinity antibody that detects the DYKDDDDK FLAG peptide.

Science.gov (United States)

Ikeda, Koki; Koga, Tomoaki; Sasaki, Fumiyuki; Ueno, Ayumi; Saeki, Kazuko; Okuno, Toshiaki; Yokomizo, Takehiko

2017-05-13

DYKDDDDK peptide (FLAG) is a useful tool for investigating the function and localization of proteins whose antibodies (Abs) are not available. We recently established a high-affinity monoclonal antibody (mAb) for FLAG (clone 2H8). The 2H8 Ab is highly sensitive for detecting FLAG-tagged proteins by flowcytometry and immunoprecipitation, but it can yield nonspecific signals in immunohistochemistry of mouse tissues because it is of mouse origin. In this study, we reduced nonspecific signals by generating a chimeric 2H8 Ab with Fc fragments derived from human immunoglobulin. We fused a 5' terminal cDNA fragments for the Fab region of 2H8 mAb with 3' terminal cDNA fragments for Fc region of human IgG1. We transfected both chimeric plasmids and purified the resulting human-mouse chimeric 2H8. The chimeric 2H8 Ab successfully detected FLAG-tagged proteins in flowcytometry with anti-human IgG secondary Ab with comparable sensitivity to 2H8 mAb. Importantly, chimeric 2H8 detected specific FLAG peptide signals without nonspecific signals in immunohistochemical analysis with mouse tissues. This human-mouse chimeric high-affinity anti-FLAG Ab will prove useful for future immunohistochemical analysis of mouse tissues. Copyright © 2017 Elsevier Inc. All rights reserved.

Equivelar toroids with few flag-orbits

OpenAIRE

Collins, José; Montero, Antonio

2018-01-01

An $(n+1)$-toroid is a quotient of a tessellation of the $n$-dimensional Euclidean space with a lattice group. Toroids are generalizations of maps in the torus on higher dimensions and also provide examples of abstract polytopes. Equivelar toroids are those that are induced by regular tessellations. In this paper we present a classification of equivelar $(n+1)$-toroids with at most $n$ flag-orbits; in particular, we discuss a classification of $2$-orbit toroids of arbitrary dimension.

Early protection events in swine immunized with an experimental live attenuated classical swine fever marker vaccine, FlagT4G.

Directory of Open Access Journals (Sweden)

Lauren G Holinka

Full Text Available Prophylactic vaccination using live attenuated classical swine fever (CSF vaccines has been a very effective method to control the disease in endemic regions and during outbreaks in previously disease-free areas. These vaccines confer effective protection against the disease at early times post-vaccination although the mechanisms mediating the protection are poorly characterized. Here we present the events occurring after the administration of our in-house developed live attenuated marker vaccine, FlagT4Gv. We previously reported that FlagT4Gv intramuscular (IM administered conferred effective protection against intranasal challenge with virulent CSFV (BICv as early as 7 days post-vaccination. Here we report that FlagT4Gv is able to induce protection against disease as early as three days post-vaccination. Immunohistochemical testing of tissues from FlagT4Gv-inoculated animals showed that tonsils were colonized by the vaccine virus by day 3 post-inoculation. There was a complete absence of BICv in tonsils of FlagT4Gv-inoculated animals which had been intranasal (IN challenged with BICv 3 days after FlagT4Gv infection, confirming that FlagT4Gv inoculation confers sterile immunity. Analysis of systemic levels of 19 different cytokines in vaccinated animals demonstrated an increase of IFN-α three days after FlagT4Gv inoculation compared with mock infected controls.

And another thing - flags of convenience

International Nuclear Information System (INIS)

Flatern, R. von

2002-01-01

Crude oil being shipped around the world, when spilled, is a threat to the environment unlike any other commodity, save perhaps for radioactive materials. Therefore, if the oil industry expects to be taken seriously in its role of protecting the environment, it must assume responsibility for its product from wellhead to consumer. Whilst there are many operators paying considerable attention to transportation issues - the largest of them using their own double-hulled tanker fleets - there still too many using ships unsuitable for the purpose, either because of age or the fact that they are single hulled vessels. These derelicts are kept in business by owners who have registered them in country's where inspections are a local joke, registration requires only a fraction of the fee charged by more conscientious nations, and taxes are low. Ships flying flags of convenience have no ties to any country, including the ones in which they are registered. The author says that it is up to the oil industry to clean up their act, for instance they could refuse to use ships that sail under a flag of convenience or single hulled vessels to move their product. The major and large independent companies learned some time ago that taking care of the environment is very much in their interest, and further that only they can do it effectively

Low back pain and physiotherapy use of red flags: the evidence from Scotland.

Science.gov (United States)

Ferguson, Fraser; Holdsworth, Lesley; Rafferty, Danny

2010-12-01

Red flags are recognised as indicators of possible serious spinal pathology, and their use is indicated by numerous guidelines. Similar to other countries worldwide, Scotland lacked a national view about the overall quality of the physiotherapy management of low back pain and the use of red flags. Anecdotal evidence suggested that practice varied considerably. To improve the use and documentation of red flags by physiotherapists during the assessment and management of low back pain. Prospective, multicentred, national data collection and improvement initiative. National Health Service (NHS) health boards in Scotland (n=14) plus two private provider sites. One hundred and eighty-six individual NHS provider sites and two private provider sites, with in excess of 360 physiotherapists providing services to low back pain patients. Measurement of documented practice in line with evidence- and consensus-based recommendations from guidelines collected via a web-based tool over two 5-week audit cycles interspersed with an improvement phase over 1 year (2008-2009). Data from 2147 patients showed improvement in the documentation of all red flags assessed from 33% (n=709) to 65% (n=1396), and improvement in the documentation of cauda equina syndrome from 60% (n=1288) to 84% (n=1804) over the two cycles. Only two regions provided evidence of 100% documentation of all components of cauda equina syndrome, with wide variation across the country. This national initiative resulted in considerable improvement in the documentation of red flags. Despite this, however, one in five patients did not receive optimal management as recommended by guidance. This has significant implications for patient safety and highlights the need for ongoing education of physiotherapists in this area. Copyright © 2010 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

The flagellar protein FLAG1/SMP1 is a candidate for Leishmania-sand fly interaction.

Science.gov (United States)

Di-Blasi, Tatiana; Lobo, Amanda R; Nascimento, Luanda M; Córdova-Rojas, Jose L; Pestana, Karen; Marín-Villa, Marcel; Tempone, Antonio J; Telleria, Erich L; Ramalho-Ortigão, Marcelo; McMahon-Pratt, Diane; Traub-Csekö, Yara M

2015-03-01

Leishmaniasis is a serious problem that affects mostly poor countries. Various species of Leishmania are the agents of the disease, which take different clinical manifestations. The parasite is transmitted by sandflies, predominantly from the Phlebotomus genus in the Old World and Lutzomyia in the New World. During development in the gut, Leishmania must survive various challenges, which include avoiding being expelled with blood remnants after digestion. It is believed that attachment to the gut epithelium is a necessary step for vector infection, and molecules from parasites and sand flies have been implicated in this attachment. In previous work, monoclonal antibodies were produced against Leishmania. Among these an antibody was obtained against Leishmania braziliensis flagella, which blocked the attachment of Leishmania panamensis flagella to Phlebotomus papatasi guts. The protein recognized by this antibody was identified and named FLAG1, and the complete FLAG1 gene sequence was obtained. This protein was later independently identified as a small, myristoylated protein and called SMP1, so from now on it will be denominated FLAG1/SMP1. The FLAG1/SMP1 gene is expressed in all developmental stages of the parasite, but has higher expression in promastigotes. The anti-FLAG1/SMP1 antibody recognized the flagellum of all Leishmania species tested and generated the expected band by western blots. This antibody was used in attachment and infection blocking experiments. Using the New World vector Lutzomyia longipalpis and Leishmania infantum chagasi, no inhibition of attachment ex vivo or infection in vivo was seen. On the other hand, when the Old World vectors P. papatasi and Leishmania major were used, a significant decrease of both attachment and infection were seen in the presence of the antibody. We propose that FLAG1/SMP1 is involved in the attachment/infection of Leishmania in the strict vector P. papatasi and not the permissive vector L. longipalpis.

Review article: liver transplantation for hepatocellular carcinoma - a critical appraisal of the current worldwide listing criteria.

Science.gov (United States)

Menon, K V; Hakeem, A R; Heaton, N D

2014-10-01

Liver transplantation (LT) plays an important role in the management of patients with hepatocellular carcinoma (HCC). Although early results following LT for HCC were poor, since the introduction of the Milan criteria in 1996 morphological criteria have since been well established. Thereafter, various expansions of the Milan criteria were introduced worldwide. Listing criteria for LT for HCC in the United Kingdom (UK) initially conformed to the Milan criteria but were re-defined in 2009 by expansion of the Milan criteria. To look at the evidence in literature on listing criteria and management of HCC worldwide in comparison with the UK. Secondly, we aim to review worldwide vs. UK literature on prioritisation models, loco-regional therapy protocols and role of alpha-fetoprotein (AFP) in LT for HCC. An electronic literature search with Medline was carried out to identify articles related to LT for HCC. Although various expansions of the Milan criteria have been described, they remain the gold standard against which other criteria are measured. The UK criteria are an expansion of the Milan criteria that go beyond Milan and University of California, San Francisco (UCSF) criteria. The current UK listing criteria for LT for HCC when compared to the worldwide criteria have a worse survival benefit (projected 5-year survival between 35-50%) when plotted on the metroticket calculator. In keeping with most transplant centres worldwide, the UK have adopted expansions to Milan to allow more patients to benefit from LT. However, currently, as it stands the UK criteria when plotted in the modification of the Metroticket model project worse survival that would seem unjustified. © 2014 John Wiley & Sons Ltd.

48 CFR 47.403-1 - Availability and unavailability of U.S.-flag air carrier service.

Science.gov (United States)

2010-10-01

... farthest interchange point on a usually traveled route. (2) When an origin or interchange point is not... interchange point on a usually traveled route to connect with U.S.-flag air carrier service. (3) When a U.S... travel by a foreign-flag air carrier. (e) For travel between two points outside the United States, the...

FLAG-tagged CD19-specific CAR-T cells eliminate CD19-bearing solid tumor cells in vitro and in vivo.

Science.gov (United States)

Berahovich, Robert; Xu, Shirley; Zhou, Hua; Harto, Hizkia; Xu, Qumiao; Garcia, Andres; Liu, Fenyong; Golubovskaya, Vita M; Wu, Lijun

2017-06-01

Autologous T cells expressing chimeric antigen receptors (CARs) specific for CD19 have demonstrated remarkable efficacy as therapeutics for B cell malignancies. In the present study, we generated FLAG-tagged CD19-specific CAR-T cells (CD19-FLAG) and compared them to their non-tagged counterparts for their effects on solid and hematological cancer cells in vitro and in vivo . For solid tumors, we used HeLa cervical carcinoma cells engineered to overexpress CD19 (HeLa-CD19), and for hematological cancer we used Raji Burkitt's lymphoma cells, which endogenously express CD19. Like non-tagged CD19 CAR-T cells, CD19-FLAG CAR-T cells expanded in culture >100-fold and exhibited potent cytolytic activity against both HeLa-CD19 and Raji cells in vitro . CD19-FLAG CAR-T cells also secreted significantly more IFN-gamma and IL-2 than the control T cells. In vivo , CD19-FLAG CAR-T cells significantly blocked the growth of HeLa-CD19 solid tumors, increased tumor cleaved caspase-3 levels, and expanded systemically. CD19-FLAG CAR-T cells also significantly reduced Raji tumor burden and extended mouse survival. These results demonstrate the strong efficacy of FLAG-tagged CD19 CAR-T cells in solid and hematological cancer models.

Discovering "The Italian Flag" by Fernando Melani (1907-1985).

Science.gov (United States)

Carlesi, Serena; Bartolozzi, Giovanni; Cucci, Costanza; Marchiafava, Veronica; Picollo, Marcello; La Nasa, Jacopo; Di Girolamo, Francesca; Dilillo, Marialaura; Modugno, Francesca; Degano, Ilaria; Colombini, Maria Perla; Legnaioli, Stefano; Lorenzetti, Giulia; Palleschi, Vincenzo

2016-11-05

In the occasion of the celebrations for the 150th anniversary of the founding of Italy (1861-2011), it was decided to analyse the artwork "The Italian Flag" (La Bandiera Italiana) created by the artist Fernando Melani (Pistoia, 1907-1985), one of the precursors of the Poor Art artistic movement in Italy. This project is a follow-up to a previous study which was mainly focused on the pigments and dyes found in his home-studio. The main goal of this paper is to identify a correct diagnostic plan, based on the use of a combination of non-invasive and micro-invasive methodologies, in order to determine the state of preservation and define the best conservation procedures for a contemporary artwork. Visible, infrared and infrared false colour images as well as the Fibre Optic Reflectance Spectroscopy (FORS) technique were applied in situ to analyse The Italian Flag. Laser Induced Breakdown Spectroscopy (LIBS), Fourier Transform Infrared (FT-IR) and micro-Raman spectroscopies, Pyrolysis-Gas Chromatography/Mass Spectroscopy (Py-GC/MS), High Performance Liquid Chromatography with Diode Arrays Detection (HPLC-DAD) and Mass Spectrometric Detection (HPLC-ESI-Q-ToF) were all applied to three small samples detached from the three painted (green-blue, white and red-yellow, respectively) areas of the flag. The combination of the data obtained with all these techniques made possible a comprehensive understanding of both the chemical composition and physical behaviour of the materials used by the artist and supported curators in defining the preventive conservation of this artwork. Copyright © 2016 Elsevier B.V. All rights reserved.

Discovering "The Italian Flag" by Fernando Melani (1907-1985)

Science.gov (United States)

Carlesi, Serena; Bartolozzi, Giovanni; Cucci, Costanza; Marchiafava, Veronica; Picollo, Marcello; La Nasa, Jacopo; Di Girolamo, Francesca; Dilillo, Marialaura; Modugno, Francesca; Degano, Ilaria; Colombini, Maria Perla; Legnaioli, Stefano; Lorenzetti, Giulia; Palleschi, Vincenzo

2016-11-01

In the occasion of the celebrations for the 150th anniversary of the founding of Italy (1861-2011), it was decided to analyse the artwork ;The Italian Flag; (La Bandiera Italiana) created by the artist Fernando Melani (Pistoia, 1907-1985), one of the precursors of the Poor Art artistic movement in Italy. This project is a follow-up to a previous study which was mainly focused on the pigments and dyes found in his home-studio. The main goal of this paper is to identify a correct diagnostic plan, based on the use of a combination of non-invasive and micro-invasive methodologies, in order to determine the state of preservation and define the best conservation procedures for a contemporary artwork. Visible, infrared and infrared false colour images as well as the Fibre Optic Reflectance Spectroscopy (FORS) technique were applied in situ to analyse The Italian Flag. Laser Induced Breakdown Spectroscopy (LIBS), Fourier Transform Infrared (FT-IR) and micro-Raman spectroscopies, Pyrolysis-Gas Chromatography/Mass Spectroscopy (Py-GC/MS), High Performance Liquid Chromatography with Diode Arrays Detection (HPLC-DAD) and Mass Spectrometric Detection (HPLC-ESI-Q-ToF) were all applied to three small samples detached from the three painted (green-blue, white and red-yellow, respectively) areas of the flag. The combination of the data obtained with all these techniques made possible a comprehensive understanding of both the chemical composition and physical behaviour of the materials used by the artist and supported curators in defining the preventive conservation of this artwork.

Fluid-structure-interaction of a flag in a channel flow

Science.gov (United States)

Liu, Yingzheng; Yu, Yuelong; Zhou, Wenwu; Wang, Weizhe

2017-11-01

The unsteady flow field and flapping dynamics of an inverted flag in water channel are investigated using time resolved particle image velocimetry (TR-PIV) measurements. The dynamically deformed profiles of the inverted flag are determined by a novel algorithm that combines morphological image processing and principle component analysis. Instantaneous flow field, phase averaged vorticity, time-mean flow field and turbulent kinematic energy are addressed for the flow. Four modes are discovered as the dimensionless bending stiffness decreases, i.e., the straight mode, the biased mode, the flapping mode and the deflected mode. Among all modes, the flapping mode is characterized by large flapping amplitude and the reverse von Kármán vortex street wake, which is potential to enhance heat transfer remarkably. National Natural Science Foundation of China.

Bioenergetic Consequences of FLAG Tag Addition to the C-Terminus of Subunit 8 of Yeast Saccharomyces cerevisiae Mitochondrial ATP Synthase

Directory of Open Access Journals (Sweden)

I MADE ARTIKA

2010-09-01

Full Text Available The yeast mitochondrial F1F0-ATP synthase is a multisubunit complex that contains at least 17 different subunits. Subunit 8 of yeast mitochondrial ATP synthase is a hydrophobic protein of 48 amino acids encoded by the mitochondrial ATP8 gene. Subunit 8 has three distinct domains; an N-terminal domain, a central hydrophobic domain and a C-terminal domain. FLAG tag addition to subunit 8 protein potentially facilitate elucidation of its topology, structure, and function. It has been shown that following incorporation of FLAG tag to its C-terminus, subunit 8 still assemble into functional ATP synthase complex. In order to analyze bioenergetic consequences of the FLAG tag addition, a yeast strain expressing FLAG tagged-subunit 8 was subjected to cellular respiration assays. Results obtained showed that addition of FLAG tag to the C-terminus of subunit 8 does not impair its proper functioning. The FLAG tag system, therefore, can be employed to study subunit 8′s detailed structure, topology, and function.

Quantum cohomology of flag manifolds and Toda lattices

International Nuclear Information System (INIS)

Givental, A.; Kim, B.

1995-01-01

We discuss relations of Vafa's quantum cohomology with Floer's homology theory, introduce equivariant quantum cohomology, formulate some conjectures about its general properties and, on the basis of these conjectures, compute quantum cohomology algebras of the flag manifolds. The answer turns out to coincide with the algebra of regular functions on an invariant lagrangian variety of a Toda lattice. (orig.)

Structure of anti-FLAG M2 Fab domain and its use in the stabilization of engineered membrane proteins

International Nuclear Information System (INIS)

Roosild, Tarmo P.; Castronovo, Samantha; Choe, Senyon

2006-01-01

The X-ray crystallographic analysis of anti-FLAG M2 Fab is reported and the implications of the structure on FLAG epitope binding are described as a first step in the development of a tool for the structural and biophysical study of membrane proteins. The inherent difficulties of stabilizing detergent-solubilized integral membrane proteins for biophysical or structural analysis demand the development of new methodologies to improve success rates. One proven strategy is the use of antibody fragments to increase the ‘soluble’ portion of any membrane protein, but this approach is limited by the difficulties and expense associated with producing monoclonal antibodies to an appropriate exposed epitope on the target protein. Here, the stabilization of a detergent-solubilized K + channel protein, KvPae, by engineering a FLAG-binding epitope into a known loop region of the protein and creating a complex with Fab fragments from commercially available anti-FLAG M2 monoclonal antibodies is reported. Although well diffracting crystals of the complex have not yet been obtained, during the course of crystallization trials the structure of the anti-FLAG M2 Fab domain was solved to 1.86 Å resolution. This structure, which should aid future structure-determination efforts using this approach by facilitating molecular-replacement phasing, reveals that the binding pocket appears to be specific only for the first four amino acids of the traditional FLAG epitope, namely DYKD. Thus, the use of antibody fragments for improving the stability of target proteins can be rapidly applied to the study of membrane-protein structure by placing the short DKYD motif within a predicted peripheral loop of that protein and utilizing commercially available anti-FLAG M2 antibody fragments

Vortex dynamics and heat transfer behind self-oscillating inverted flags of various lengths in channel flow

Science.gov (United States)

Yu, Yuelong; Liu, Yingzheng; Chen, Yujia

2018-04-01

The influence of an inverted flag's length-to-channel-width ratio (C* = L/W) on its oscillating behavior in a channel flow and the resultant vortex dynamics and heat transfer are determined experimentally. Three systems with C* values of 0.125, 0.250, and 0.375 were chosen for comparison. The interaction of highly unsteady flow with the inverted flag is measured with time-resolved particle image velocimetry. Variations in the underlying flow physics are discussed in terms of the statistical flow quantities, flag displacement, phase-averaged flow field, and vortex dynamics. The results show that the increase in C* shifts the occurrence of the flapping regime at high dimensionless bending stiffness. With the flag in the flapping region, three distinct vortex dynamics—the von Kármán vortex street, the G mode, and the singular mode—are identified at C* values of 0.375, 0.250, and 0.125, respectively. Finally, the heat transfer enhancement from the self-oscillating inverted flag is measured to serve as complementary information to quantify the cause-and-effect relationship between vortex dynamics and wall heat transfer. The increase in C* strongly promotes wall heat removal because disruption of the boundary layer by the energetic vortices is substantially intensified. Among all systems, wall heat transfer removal is most efficient at the intermediate C* value of 0.250.

THE STATE PRESIDENT'S FLAG SINCE 4 SEPTEMBER 1984

African Journals Online (AJOL)

The heraldic description of the flag reads as follows: a rectangular tricolour, ratio three by two, with three triangular fields (top to bottom) in orange, white and blue. The white charged in the hoist with the coat of arms of the Republic of. South Africa. Above the coat of arms the letter. 'SP' are ensigned in gold with black ...

A Preliminary Assessment of the SURF Reactive Burn Model Implementation in FLAG

Energy Technology Data Exchange (ETDEWEB)

Johnson, Carl Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); McCombe, Ryan Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carver, Kyle [United States Air Force, Washington, DC (United States)

2017-09-18

Properly validated and calibrated reactive burn models (RBM) can be useful engineering tools for assessing high explosive performance and safety. Experiments with high explosives are expensive. Inexpensive RBM calculations are increasingly relied on for predictive analysis for performance and safety. This report discusses the validation of Menikoff and Shaw’s SURF reactive burn model, which has recently been implemented in the FLAG code. The LANL Gapstick experiment is discussed as is its’ utility in reactive burn model validation. Data obtained from pRad for the LT-63 series is also presented along with FLAG simulations using SURF for both PBX 9501 and PBX 9502. Calibration parameters for both explosives are presented.

Analysis of historical and recent PBX 9404 cylinder tests using FLAG

Energy Technology Data Exchange (ETDEWEB)

Wooten, Hasani Omar [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Whitley, Von Howard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-01-31

Cylinder test experiments using aged PBX-9404 were recently conducted. When compared to similar historical tests using the same materials, but different diagnostics, the data indicate that PBX 9404 imparts less energy to surrounding copper. The purpose of this work was to simulate historical and recent cylinder tests using the Lagrangian hydrodynamics code, FLAG, and identify any differences in the energetic behavior of the material. Nine experiments spanning approximately 4.5 decades were simulated, and radial wall expansions and velocities were compared. Equation-of-state parameters were adjusted to obtain reasonable matches with experimental data. Pressure-volume isentropes were integrated, and resultant energies at specific volume expansions were compared. FLAG simulations matched to experimental data indicate energetic changes of approximately -0.57% to -0.78% per decade.

14 CFR 1221.106 - Establishment of the NASA Flag.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Establishment of the NASA Flag. 1221.106 Section 1221.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION THE NASA SEAL AND OTHER DEVICES, AND THE CONGRESSIONAL SPACE MEDAL OF HONOR NASA Seal, NASA Insignia, NASA Logotype, NASA...

14 CFR 1221.113 - Use of the NASA Flags.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Use of the NASA Flags. 1221.113 Section 1221.113 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION THE NASA SEAL AND OTHER DEVICES, AND THE CONGRESSIONAL SPACE MEDAL OF HONOR NASA Seal, NASA Insignia, NASA Logotype, NASA Program...

Knowledge and Utilization of Red Flags by Physiotherapists in the ...

African Journals Online (AJOL)

DR. BASHIR BELLO

majority of the physiotherapists 44 (88%) had knowledge of red flags but only 14 (28%) ... documented, while medical history of cancer, HIV status, as well as history of fever were .... The main objective of this study was to determine the level.

75 FR 13645 - Inventory of U.S.-Flag Launch Barges

Science.gov (United States)

2010-03-22

... Qualified Launch Barges, the Interim Final Rule requires that the Maritime Administration publish a notice... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2010 0023] Inventory of U.S.-Flag Launch Barges AGENCY: Maritime Administration, Department of Transportation. ACTION: Inventory of...

76 FR 20080 - Inventory of U.S.-Flag Launch Barges

Science.gov (United States)

2011-04-11

... Administration publish a notice in the Federal Register requesting that owners or operators (or potential owners... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket Number MARAD 2011 0030] Inventory of U.S.-Flag Launch Barges AGENCY: Maritime Administration, Department of Transportation. ACTION...

50 CFR 216.46 - U.S. citizens on foreign flag vessels operating under the International Dolphin Conservation...

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false U.S. citizens on foreign flag vessels operating under the International Dolphin Conservation Program. 216.46 Section 216.46 Wildlife and Fisheries....46 U.S. citizens on foreign flag vessels operating under the International Dolphin Conservation...

Flag varieties an interplay of geometry, combinatorics, and representation theory

CERN Document Server

Lakshmibai, V

2009-01-01

Flag varieties are important geometric objects and their study involves an interplay of geometry, combinatorics, and representation theory. This book is detailed account of this interplay. In the area of representation theory, the book presents a discussion of complex semisimple Lie algebras and of semisimple algebraic groups; in addition, the representation theory of symmetric groups is also discussed. In the area of algebraic geometry, the book gives a detailed account of the Grassmannian varieties, flag varieties, and their Schubert subvarieties. Because of the connections with root systems, many of the geometric results admit elegant combinatorial description, a typical example being the description of the singular locus of a Schubert variety. This is shown to be a consequence of standard monomial theory (abbreviated SMT). Thus the book includes SMT and some important applications - singular loci of Schubert varieties, toric degenerations of Schubert varieties, and the relationship between Schubert variet...

Red Flags for Low Back Pain Are Not Always Really Red: A Prospective Evaluation of the Clinical Utility of Commonly Used Screening Questions for Low Back Pain.

Science.gov (United States)

Premkumar, Ajay; Godfrey, William; Gottschalk, Michael B; Boden, Scott D

2018-03-07

Low back pain has a high prevalence and morbidity, and is a source of substantial health-care spending. Numerous published guidelines support the use of so-called red flag questions to screen for serious pathology in patients with low back pain. This paper examines the effectiveness of red flag questions as a screening tool for patients presenting with low back pain to a multidisciplinary academic spine center. We conducted a retrospective review of the cases of 9,940 patients with a chief complaint of low back pain. The patients completed a questionnaire that included several red flag questions during their first physician visit. Diagnostic data for the same clinical episode were collected from medical records and were corroborated with imaging reports. Patients who were diagnosed as having a vertebral fracture, malignancy, infection, or cauda equina syndrome were classified as having a red flag diagnosis. Specific individual red flags and combinations of red flags were associated with an increased probability of underlying serious spinal pathology, e.g., recent trauma and an age of >50 years were associated with vertebral fracture. The presence or absence of other red flags, such as night pain, was unrelated to any particular diagnosis. For instance, for patients with no recent history of infection and no fever, chills, or sweating, the presence of night pain was a false-positive finding for infection >96% of the time. In general, the absence of red flag responses did not meaningfully decrease the likelihood of a red flag diagnosis; 64% of patients with spinal malignancy had no associated red flags. While a positive response to a red flag question may indicate the presence of serious disease, a negative response to 1 or 2 red flag questions does not meaningfully decrease the likelihood of a red flag diagnosis. Clinicians should use caution when utilizing red flag questions as screening tools.

FLAG Simulations of the Elasticity Test Problem of Gavrilyuk et al.

Energy Technology Data Exchange (ETDEWEB)

Kamm, James R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Runnels, Scott R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Canfield, Thomas R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carney, Theodore C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2014-04-23

This report contains a description of the impact problem used to compare hypoelastic and hyperelastic material models, as described by Gavrilyuk, Favrie & Saurel. That description is used to set up hypoelastic simulations in the FLAG hydrocode.

General and Flag Officer Careers: Consequences of Increased Tenure

National Research Council Canada - National Science Library

Thie, Harry

2001-01-01

.... As a result of these concerns, Congress asked the Secretary of Defense to review the career patterns of flag-rank officers. It requested specific data about average time-in-grade both when selected and when promoted as well as the length of tours. It also asked the Secretary to assess the appropriateness of mandatory retirement at 35 years.

The Savannah River Site`s Groundwater Monitoring Program, second quarter 1990

Energy Technology Data Exchange (ETDEWEB)

1991-02-07

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site`s (SRS) Groundwater Monitoring Program. During second quarter 1990 (April through June) EPD/EMS conducted routine sampling of monitoring wells and drinking water locations. EPD/EMS established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria aid personnel in sample scheduling, interpretation of data, and trend identification. The flagging criteria are based on detection limits, background levels in SRS groundwater, and drinking water standards. An explanation of flagging criteria for the second quarter is presented in the Flagging Criteria section of this document. All analytical results from second quarter 1990 are listed in this report.

The Savannah River Site's Groundwater Monitoring Program, second quarter 1990

Energy Technology Data Exchange (ETDEWEB)

1991-02-07

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site's (SRS) Groundwater Monitoring Program. During second quarter 1990 (April through June) EPD/EMS conducted routine sampling of monitoring wells and drinking water locations. EPD/EMS established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria aid personnel in sample scheduling, interpretation of data, and trend identification. The flagging criteria are based on detection limits, background levels in SRS groundwater, and drinking water standards. An explanation of flagging criteria for the second quarter is presented in the Flagging Criteria section of this document. All analytical results from second quarter 1990 are listed in this report.

Modifying Flag Football for Gender Equitable Engagement in Secondary Schools

Science.gov (United States)

Kahan, David

2008-01-01

Flag or touch football is a popular activity unit in American secondary physical education curricula. However, unlike other sports its stigmatization as a masculine-typed activity and frequent inequitable distribution of game play opportunities at the skill positions (e.g., receiver, quarterback) results in the marginalization of female…

Vortex dynamics behind a self-oscillating inverted flag placed in a channel flow: Time-resolved particle image velocimetry measurements

Science.gov (United States)

Yu, Yuelong; Liu, Yingzheng; Chen, Yujia

2017-12-01

The unsteady flow behind an inverted flag placed in a water channel and then excited into a self-oscillating state is measured using time-resolved particle image velocimetry. The dynamically deformed profiles of the inverted flag are determined by a novel algorithm that combines morphological image processing and principle component analysis. Three modes are discovered with the successive decrease in the dimensionless bending stiffness: the biased mode, the flapping mode, and the deflected mode. The distinctly different flow behavior is discussed in terms of instantaneous velocity field, phase-averaged vorticity field, time-mean flow field, and turbulent kinetic energy. The results demonstrated that the biased mode generated abundant vortices at the oscillating side of the inverted flag. In the deflected mode, the inverted flag is highly deflected to one side of the channel and remains almost stationary, inducing two stable recirculation zones and a considerably inversed flow between them. In the flapping mode, the strongly oscillating flag periodically provides a strengthened influence on the fluid near the two sidewalls. The reverse von Kármán vortex street is well formed and energetic in the wake, and a series of high-speed impingement jets between the neighboring vortices are directed toward the sidewalls in a staggered fashion.

The blood-stained flags of liberty – The struggle for adequate signs of identity in New Caledonia

Directory of Open Access Journals (Sweden)

Lindenmann, Peter

2014-09-01

Full Text Available The Nouméa treaty of 1998 that created the framework for the transition of New Caledonia from a French overseas territory towards emancipation provided also for the creation of new identity markers. Lacking a shared understanding of history and a common vision for the future, the process of adopting a flag was blocked for more than ten years. As an intermediate solution the flag of the Kanak independence movement is hoisted side by side to the French tricolour since 2010. While some loyalist parties continue to campaign for a common flag, pro-independence parties are waiting to descend the tricolour, and others would favor the status quo. The unresolved question of the right symbol is also a reflection of the uncertain political future as the referendum on independence looms.

The Explicit Construction of Einstein Finsler Metrics with Non-Constant Flag Curvature

Directory of Open Access Journals (Sweden)

Enli Guo

2009-04-01

Full Text Available By using the Hawking Taub-NUT metric, this note gives an explicit construction of a 3-parameter family of Einstein Finsler metrics of non-constant flag curvature in terms of navigation representation.

Physiological and Biochemical Characteristics in Flag Leaves of the C Liangyou Series of Hybrid Rice Combinations at Late Growth Stages

Directory of Open Access Journals (Sweden)

Wen-bang TANG

2010-12-01

Full Text Available The contents of chlorophyll, soluble sugars, soluble proteins and thiobarbituric acid reaction substance (TBARS, chlorophyll fluorescence parameters, net photosynthetic rate as well as the activities of superoxide dismutase (SOD and peroxidase (POD of flag leaves at the late growth stages were studied by using C Liangyou series of hybrid rice combinitions as material and Shanyou 63 as control. The C Liangyou series of hybrid rice combinations used in the experiment included C Liangyou 396, C Liangyou 87, C Liangyou 755 and C Liangyou 34, which all used C815S as male sterile line. The contents of chlorophyll, soluble sugars and soluble proteins in flag leaves of the C Liangyou series combinations at the late growth stages were higher than those of the control, whereas the TBARS content was lower than that of the control. The activities of SOD and POD were significantly higher than those of the control on the 7th day after heading, and then decreased slowly. FPSII value and qP value of flag leaves decreased at the late growth stages, and these two parameters in flag leaves of the C Liangyou series combinations were higher than those of the control, while the qN value increased at the late growth stages and was lower than that of the control. The net photosynthetic rate of flag leaves at the late growth stage was higher compared with the control. These results suggest that slow senescence and strong photosynthetic capability in flag leaves at the late growth stages are the physiological basis of the C Liangyou series combinations.

CNNs flag recognition preprocessing scheme based on gray scale stretching and local binary pattern

Science.gov (United States)

Gong, Qian; Qu, Zhiyi; Hao, Kun

2017-07-01

Flag is a rather special recognition target in image recognition because of its non-rigid features with the location, scale and rotation characteristics. The location change can be handled well by the depth learning algorithm Convolutional Neural Networks (CNNs), but the scale and rotation changes are quite a challenge for CNNs. Since it has good rotation and gray scale invariance, the local binary pattern (LBP) is combined with grayscale stretching and CNNs to make LBP and grayscale stretching as CNNs pretreatment, which can not only significantly improve the efficiency of flag recognition, but can also evaluate the recognition effect through ROC, accuracy, MSE and quality factor.

Dynamic Black-Level Correction and Artifact Flagging for Kepler Pixel Time Series

Science.gov (United States)

Kolodziejczak, J. J.; Clarke, B. D.; Caldwell, D. A.

2011-01-01

Methods applied to the calibration stage of Kepler pipeline data processing [1] (CAL) do not currently use all of the information available to identify and correct several instrument-induced artifacts. These include time-varying crosstalk from the fine guidance sensor (FGS) clock signals, and manifestations of drifting moire pattern as locally correlated nonstationary noise, and rolling bands in the images which find their way into the time series [2], [3]. As the Kepler Mission continues to improve the fidelity of its science data products, we are evaluating the benefits of adding pipeline steps to more completely model and dynamically correct the FGS crosstalk, then use the residuals from these model fits to detect and flag spatial regions and time intervals of strong time-varying black-level which may complicate later processing or lead to misinterpretation of instrument behavior as stellar activity.

An anisotropic elastoplasticity model implemented in FLAG

Energy Technology Data Exchange (ETDEWEB)

Buechler, Miles Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Canfield, Thomas R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-10-12

Many metals, including Tantalum and Zirconium, exhibit anisotropic elastoplastic behavior at the single crystal level, and if components are manufactured from these metals through forming processes the polycrystal (component) may also exhibit anisotropic elastoplastic behavior. This is because the forming can induce a preferential orientation of the crystals in the polycrystal. One example is a rolled plate of Uranium where the sti /strong orientation of the crystal (c-axis) tends to align itself perpendicular to the rolling direction. If loads are applied to this plate in di erent orientations the sti ness as well as the ow strength of the material will be greater in the through thickness direction than in other directions. To better accommodate simulations of such materials, an anisotropic elastoplasticity model has been implemented in FLAG. The model includes an anisotropic elastic stress model as well as an anisotropic plasticity model. The model could represent single crystals of any symmetry, though it should not be confused with a high- delity crystal plasticity model with multiple slip planes and evolutions. The model is most appropriate for homogenized polycrystalline materials. Elastic rotation of the material due to deformation is captured, so the anisotropic models are appropriate for arbitrary large rotations, but currently they do not account for signi cant change in material texture beyond the elastic rotation of the entire polycrystal.

The Savannah River Site's Groundwater Monitoring Program, second quarter 1989

Energy Technology Data Exchange (ETDEWEB)

1989-01-01

The Environmental Monitoring Section of the Environmental and Health Protection (EHP) Department administers the Savannah River Site's Groundwater Monitoring Program. During second quarter 1989 (April--June), EHP conducted routine sampling of monitoring wells and drinking water locations. EHP collected the drinking water samples from Savannah River Site (SRS) drinking water systems supplied by wells. EHP established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria aid personnel in sample scheduling, interpretation of data, and trend identification. The flagging criteria are based on detection limits, background levels in SRS groundwater, and drinking water standards. An explanation of flagging criteria for the second quarter is presented in the Flagging Criteria section of this document. All analytical results from second quarter 1989 are listed in this report, which is distributed to all waste-site custodians.

The Savannah River Site`s Groundwater Monitoring Program, second quarter 1989

Energy Technology Data Exchange (ETDEWEB)

1989-12-31

The Environmental Monitoring Section of the Environmental and Health Protection (EHP) Department administers the Savannah River Site`s Groundwater Monitoring Program. During second quarter 1989 (April--June), EHP conducted routine sampling of monitoring wells and drinking water locations. EHP collected the drinking water samples from Savannah River Site (SRS) drinking water systems supplied by wells. EHP established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria aid personnel in sample scheduling, interpretation of data, and trend identification. The flagging criteria are based on detection limits, background levels in SRS groundwater, and drinking water standards. An explanation of flagging criteria for the second quarter is presented in the Flagging Criteria section of this document. All analytical results from second quarter 1989 are listed in this report, which is distributed to all waste-site custodians.

Red flags to screen for malignancy and fracture in patients with low back pain: systematic review

DEFF Research Database (Denmark)

Downie, A.; Williams, C.M.; Henschke, N.

2013-01-01

Objective: To review the evidence on diagnostic accuracy of red flag signs and symptoms to screen for fracture or malignancy in patients presenting with low back pain to primary, secondary, or tertiary care. Design: Systematic review. Data sources: Medline, OldMedline, Embase, and CINAHL from......-test probability for detection of spinal malignancy was history of malignancy (33%, 22% to 46%). Conclusions: While several red flags are endorsed in guidelines to screen for fracture or malignancy, only a small subset of these have evidence that they are indeed informative. These findings suggest a need...

Worker flag. Independent Electrical Policy

International Nuclear Information System (INIS)

Bahen, D.

2000-01-01

This work analyses the initiative of privatization of the Mexican Electric Industry and also it is showed the incoherence of this mistaken proposal. Along the same line is analysed tthe situation of the National Electric Sector and the working process for the distinct types of electric generation just as the syndical and labor situations. In consequence it is proposed an Independent Electrical Policy, which includes the integration of the Nationalized Electric Industry, the syndical union and the Unique Collective Contract. The purpose of this work is to contribute to the success of the electrical and nuclear struggle always maintaining in rising position the red flag of the proletariat. The author considers that the privatization means mercantilization of the human necessities. The privatization is not inevitable at condition of to exercise consequently the political actions necessary through alternatives includes: the worker control of production, research, and the National Electric strike. (Author)

The Savannah River Site's Groundwater Monitoring Program, third quarter 1989

Energy Technology Data Exchange (ETDEWEB)

1989-01-01

The Environmental Monitoring Section of the Environmental and Health Protection (EHP) Department administers the Savannah River Site's Groundwater Monitoring Program. During third quarter 1989 (July--September), EHP conducted routine sampling of monitoring wells and drinking water locations. EHP collected the drinking water samples from Savannah River Site (SRS) drinking water systems supplied by wells. EHP established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria do not define contamination levels; instead they aid personnel in sample scheduling, interpretation of data, and trend identification. The flagging criteria are based on detection limits, background levels in SRS groundwater, and drinking water standards. An explanation of flagging criteria for the third quarter is presented in the Flagging Criteria section of this document. All analytical results from third quarter 1989 are listed in this report, which is distributed to all waste-site custodians.

The Savannah River Site`s Groundwater Monitoring Program, third quarter 1989

Energy Technology Data Exchange (ETDEWEB)

1989-12-31

The Environmental Monitoring Section of the Environmental and Health Protection (EHP) Department administers the Savannah River Site`s Groundwater Monitoring Program. During third quarter 1989 (July--September), EHP conducted routine sampling of monitoring wells and drinking water locations. EHP collected the drinking water samples from Savannah River Site (SRS) drinking water systems supplied by wells. EHP established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria do not define contamination levels; instead they aid personnel in sample scheduling, interpretation of data, and trend identification. The flagging criteria are based on detection limits, background levels in SRS groundwater, and drinking water standards. An explanation of flagging criteria for the third quarter is presented in the Flagging Criteria section of this document. All analytical results from third quarter 1989 are listed in this report, which is distributed to all waste-site custodians.

Red flags in children with chronic abdominal pain and Crohn's disease-a single center experience.

Science.gov (United States)

El-Chammas, Khalil; Majeskie, Angela; Simpson, Pippa; Sood, Manu; Miranda, Adrian

2013-04-01

To compare history and symptoms at initial presentation of patients with chronic abdominal pain (CAP) and Crohn's disease (CD). Red flags are used to help determine which patients with CAP are likely to have an underlying disease such as CD. However, red flags have not been validated and pediatric studies are lacking. Patients seen in the outpatient Pediatric Gastroenterology Clinic at Children's Hospital of Wisconsin between 2005 and 2008 prospectively completed a demographic, history, and symptom questionnaire. Patients with abdominal pain for at least 1 month and no evidence of organic disease were compared with patients diagnosed with CD confirmed by mucosal biopsies. Data were collected on 606 patients (128 with CD and 478 with functional gastrointestinal disorders). Patients with functional gastrointestinal disorders had more stressors (P pain were no different between groups. Anemia, hematochezia, and weight loss were most predictive of CD (cumulative sensitivity of 94%). The presence of anemia, hematochezia, and weight loss help identify patients with CAP who require further work-up and referral to a pediatric gastroenterologist. Furthermore, waking from sleep or joint pain occurred similarly between groups and should not be considered as "red flags." Copyright © 2013. Published by Mosby, Inc.

Constructing and Validating the Foreign Language Attitudes and Goals Survey (FLAGS)

Science.gov (United States)

Cid, Eva; Granena, Gisela; Tragant, Elsa

2009-01-01

The present study describes the process that was followed in the construction and validation of the foreign language attitudes and goals survey (FLAGS), a new questionnaire based on qualitative data from Tragant and Munoz [Tragant, Munoz, C., 2000. "La motivacion y su relacion con la edad en un contexto escolar de aprendizaje de una lengua…

A CERN flag is set to wave up in the Himalayas

CERN Multimedia

Roberto Cantoni

2010-01-01

On 18 October, Hubert Reymond, from the Industrial Controls and Engineering group of the EN Department, will be leaving to Nepal with a CERN flag in his backpack. He will place it at the highest point of his trek across the Annapurna mountains in the Himalayas, Thorong La pass, at 5,416 m above sea level.   A view of the Annapurna mountains (source: www.flickr.com/minutesalone) “Is there any official CERN flag I can carry with me during my trek through Nepal?” Some days ago, the Press Office was confronted with this unusual (but see box) question from Hubert Reymond. From 18 October to 10 November, Reymond, who works as an industrial computing engineer in the EN Department, will be trekking across the 55 km-long Annapurna massif in the Himalayas, whose highest point lies at 8,091 m (making it the 10th-highest summit in the world). The area is well-known to trekkers from around the world, as it includes several world-class circuits, including the Annapurna circuit which Reym...

Phloem Transport Of Arsenic Species From Flag Leaf To Grain During Grain Filling

Science.gov (United States)

Strategies to reduce arsenic (As) in rice grain, below concentrations that represent a serious human health concern, require that the mechanisms of As accumulation within grain be established. Therefore, retranslocation of As species from flag leaves into filling rice grain was ...

Early response to sibutramine in patients not meeting current label criteria: preliminary analysis of SCOUT lead-in period

DEFF Research Database (Denmark)

Caterson, Ian; Coutinho, Walmir; Finer, Nick

2010-01-01

The Sibutramine Cardiovascular Outcomes (SCOUT) trial protocol defines a patient population predominantly outside current European Union label criteria. This article explores responses to sibutramine during the 6-week, single-blind, lead-in period between patients who conformed to the label...... requirements ("conformers") and those who did not ("nonconformers"). SCOUT is an ongoing, randomized, double-blind, placebo-controlled outcome trial in overweight/obese patients at high risk of a cardiovascular event. In total, 10,742 patients received sibutramine and weight management during the lead...... with sibutramine confirms its good tolerability and efficacy in patients who meet current label criteria. Preliminary data from high-risk patients for whom sibutramine is currently contraindicated suggest a low discontinuation rate and few serious adverse events but confirmation from the SCOUT outcome data...

First hoisting of the Portuguese flag at CERN

CERN Multimedia

Unknown, Unknown

1986-01-01

First hoisting of the Portuguese flag at CERN, following the country's membership. Photo taken on January 22 (or 23), 1986. From left to right: António Costa Lobo (Portugal's ambassador to the UN in Geneva), Gaspar Barreira, Karin Wall (José Mariano Gago's wife), José Mariano Gago (Portugal's JNICT president), Catarina Wall Gago (José Mariano Gago's daughter), João Varela, Herwig Schopper (CERN's Director-General), Eduardo Arantes e Oliveira (Portugal's Secretary of State for Science), , Margarida Nesbitt Rebelo, , Mário Pimenta, , Gustavo Castelo Branco, João Seixas, Sérgio Ramos, and Peter Sonderegger.

TH-CD-207A-10: Using the Gamma Index to Flag Changes in Anatomy During Radiation Therapy of Head and Neck Cancer

Energy Technology Data Exchange (ETDEWEB)

Schaly, B; Battista, J [London Regional Cancer Program, London, Ontario (Canada); Department of Medical Biophysics, Western University, London, Ontario Canada (Canada); Kempe, J; Mitchell, S [London Regional Cancer Program, London, Ontario (Canada); Venkatesan, V [London Regional Cancer Program, London, Ontario (Canada); Schulich School of Medicine and Dentistry, Western University, London, Ontario (Canada)

2016-06-15

Purpose: This article presents a fast algorithm for comparing 3-D anatomy from Cone-Beam CT (CBCT) imaging using the gamma comparison index and to demonstrate how this can be used to flag patients for possible re-planning of treatment. Methods: CBCT scans acquired on a Varian linear accelerator during treatment were used as input to the gamma comparator using thresholds of 5 mm distance to agreement and 30 Hounsfield Unit CT number difference. The fraction 1 CBCT study was initially used as the reference. Should there be a re-plan during treatment, the reference resets to the CBCT study acquired on the day 1 of the re-plan. Histograms of failing pixels (γ > 1) were generated from each 3-D gamma map. An indicator of anatomy congruence, the match quality parameter (MQP), was derived from failed pixel histograms using the 90th percentile gamma value. The MQP was plotted versus fraction number and related to actual repeat computed tomography (re-CT) order dates as decided by a radiation oncologist. From this, decision criteria were derived for the algorithm to “trigger” re-CT consideration and predictive power was scored using receiver-operator characteristic (ROC) analysis. Results: The MQP plot generally showed that the on-line match from CBCT image guidance deteriorated as the treatment progressed due to weight loss and tumor regression. The optimized MQP criteria for triggering re-CT consideration demonstrated high sensitivity and specificity, consistent with actual re-CT order dates within ± 3 fractions. Out of 20 patients that were actually re-planned, the algorithm failed to trigger a re-CT recommendation only twice and this was caused by CBCT ring artifacts. Conclusion: We have demonstrated that gamma comparisons can be used to evaluate CBCT-acquired anatomy pairs and, from this, an algorithm can be “trained” to flag patients for possible re-planning in a manner consistent with local radiation oncology practice.

Diagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithm.

Science.gov (United States)

Sekijima, Yoshiki; Ueda, Mitsuharu; Koike, Haruki; Misawa, Sonoko; Ishii, Tomonori; Ando, Yukio

2018-01-17

Hereditary ATTR (ATTRm) amyloidosis (also called transthyretin-type familial amyloid polyneuropathy [ATTR-FAP]) is an autosomal-dominant, adult-onset, rare systemic disorder predominantly characterized by irreversible, progressive, and persistent peripheral nerve damage. TTR gene mutations (e.g. replacement of valine with methionine at position 30 [Val30Met (p.Val50Met)]) lead to destabilization and dissociation of TTR tetramers into variant TTR monomers, which form amyloid fibrils that deposit in peripheral nerves and various organs, giving rise to peripheral and autonomic neuropathy and several non-disease specific symptoms.Phenotypic and genetic variability and non-disease-specific symptoms often delay diagnosis and lead to misdiagnosis. Red-flag symptom clusters simplify diagnosis globally. However, in Japan, types of TTR variants, age of onset, penetrance, and clinical symptoms of Val30Met are more varied than in other countries. Hence, development of a Japan-specific red-flag symptom cluster is warranted. Presence of progressive peripheral sensory-motor polyneuropathy and ≥1 red-flag sign/symptom (e.g. family history, autonomic dysfunction, cardiac involvement, carpal tunnel syndrome, gastrointestinal disturbances, unexplained weight loss, and immunotherapy resistance) suggests ATTR-FAP. Outside of Japan, pharmacotherapeutic options are first-line therapy. However, because of positive outcomes (better life expectancy and higher survival rates) with living donor transplant in Japan, liver transplantation remains first-line treatment, necessitating a Japan-specific treatment algorithm.Herein, we present a consolidated review of the ATTR-FAP Val30Met landscape in Japan and summarize findings from a medical advisory board meeting held in Tokyo on 18th August 2016, at which a Japan-specific ATTR-FAP red-flag symptom cluster and treatment algorithm was developed. Beside liver transplantation, a TTR-stabilizing agent (e.g. tafamidis) is a treatment option. Early

Lung scintigraphy in the diagnosis of pulmonary embolism: current methods and interpretation criteria in clinical practice

International Nuclear Information System (INIS)

Skarlovnik, Ajda; Hrastnik, Damjana; Fettich, Jure; Grmek, Marko

2014-01-01

In current clinical practice lung scintigraphy is mainly used to exclude pulmonary embolism (PE). Modified diagnostic criteria for planar lung scintigraphy are considered, as newer scitigraphic methods, especially single photon emission computed tomography (SPECT) are becoming more popular. Data of 98 outpatients who underwent planar ventilation/perfusion (V/Q) scintigraphy and 49 outpatients who underwent V/Q SPECT from the emergency department (ED) were retrospectively collected. Planar V/Q images were interpreted according to 0.5 segment mismatch criteria and revised PIOPED II criteria and perfusion scans according to PISA-PED criteria. V/Q SPECT images were interpreted according to the criteria suggested in EANM guidelines. Final diagnosis of PE was based on the clinical decision of an attending physician and evaluation of a 12 months follow-up period. Using 0.5 segment mismatch criteria and revised PIOPED II, planar V/Q scans were diagnostic in 93% and 84% of cases, respectively. Among the diagnostic planar scans readings specificity for 0.5 segment mismatch criteria was 98%, and 99% for revised PIOPED II criteria. V/Q SPECT showed a sensitivity of 100% and a specificity of 98%, without any non-diagnostic cases. In patients with low pretest probability for PE, planar V/Q scans assessed by 0.5 segment mismatch criteria were diagnostic in 92%, and in 85% using revised PIOPED II criteria, while perfusion scintigraphy without ventilation scans was diagnostic in 80%. Lung scintigraphy yielded diagnostically definitive results and is reliable in ruling out PE in patients from ED. V/Q SPECT has excellent specificity and sensitivity without any non-diagnostic results. Percentage of non-diagnostic results in planar lung scintigraphy is considerably smaller when 0.5 segment mismatch criteria instead of revised PIOPED II criteria are used. Diagnostic value of perfusion scintigraphy according to PISA-PED criteria is inferior to combined V/Q scintigraphy; the difference is

Soap films burst like flapping flags.

Science.gov (United States)

Lhuissier, Henri; Villermaux, Emmanuel

2009-07-31

When punctured, a flat soap film bursts by opening a hole driven by liquid surface tension. The hole rim does not, however, remain smooth but soon develops indentations at the tip of which ligaments form, ultimately breaking and leaving the initially connex film into a mist of disjointed drops. We report on original observations showing that these indentations result from a flaglike instability between the film and the surrounding atmosphere inducing an oscillatory motion out of its plane. Just like a flag edge flaps in the wind, the film is successively accelerated on both sides perpendicularly to its plane, inducing film thickness modulations and centrifuging liquid ligaments that finally pinch off to form the observed spray. This effect exemplifies how the dynamics of fragile objects such as thin liquid films is sensitive to their embedding medium.

Sensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia

Science.gov (United States)

Piguet, O; Hornberger, M; Shelley, B P.; Kipps, C M.; Hodges, J R.

2009-01-01

Background: Diagnosis of behavioral variant frontotemporal dementia (bvFTD) relies on criteria that are constraining and potentially ambiguous. Some features are open to clinical interpretation and their prevalence unknown. This study investigated the sensitivity of current diagnostic criteria in a large group of patients with bvFTD. Methods: Forty-five patients with clear evidence of bvFTD as judged by progressive clinical decline (>3 years) with marked frontal features and significant frontal brain atrophy on brain MRI were included. Thirty-two have died; pathologic confirmation of frontotemporal lobar degeneration was found in all 18 coming to autopsy. We established the prevalence of core and supportive diagnostic features at presentation and with disease progression. Results: Only 25/45 patients (56%) showed all five core features necessary for a diagnosis of bvFTD at initial presentation and 33/45 (73%) as their disease progressed. Two core features, emotional blunting and loss of insight, were never observed in 25% and 13% of cases. Executive dysfunction, hyperorality, mental inflexibility, and distractibility were the only supportive features present in >50% of cases at initial presentation. Although not a diagnostic feature, impaired activities of daily living was present in 33/45 patients (73%). Conclusions: Strict application of the criteria misses a significant proportion of patients. Many supportive features have low prevalence and are clinically not useful. Revision of the criteria to include level of certainty (definite, probable, possible) dependent on the number of features present and the presence of ancillary information (e.g., brain atrophy, neuropsychological abnormalities, impaired activities of daily living) is encouraged. GLOSSARY ACE = Addenbrooke’s Cognitive Examination; ADL = activities of daily living; bvFTD = behavioral variant frontotemporal dementia; MMSE = Mini-Mental State Examination. PMID:19237702

The Savannah River Site`s Groundwater Monitoring Program. Fourth quarter, 1989

Energy Technology Data Exchange (ETDEWEB)

1989-12-31

The Environmental Monitoring Section of the Environmental and Health Protection (EHP) Department administers the Savannah River Site`s Groundwater Monitoring Program. During fourth quarter 1989 (October--December), EHP conducted routine sampling of monitoring wells and drinking water locations. EHP collected the drinking water samples from Savannah River Site (SRS) drinking water systems supplied by wells. EHP established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria aid personnel in sample scheduling, interpretation of data, and trend identification. An explanation of flagging criteria for the fourth quarter is presented in the Flagging Criteria section of this document. All analytical results from fourth quarter 1989 are listed in this report, which is distributed to all waste-site custodians.

The Savannah River Site's Groundwater Monitoring Program

Energy Technology Data Exchange (ETDEWEB)

1989-01-01

The Environmental Monitoring Section of the Environmental and Health Protection (EHP) Department administers the Savannah River Site's Groundwater Monitoring Program. During fourth quarter 1989 (October--December), EHP conducted routine sampling of monitoring wells and drinking water locations. EHP collected the drinking water samples from Savannah River Site (SRS) drinking water systems supplied by wells. EHP established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria aid personnel in sample scheduling, interpretation of data, and trend identification. An explanation of flagging criteria for the fourth quarter is presented in the Flagging Criteria section of this document. All analytical results from fourth quarter 1989 are listed in this report, which is distributed to all waste-site custodians.

Strategies Used In Capture The Flag Events Contributing To Team Performance

Science.gov (United States)

2016-03-01

words) Capture-the-flag (CTF) exercises are useful pedagogical tools and have been employed, both formally and informally, by academic institutions...Much like their physical counterparts, cyber CTF exercises hold pedagogical value and are gaining wide popularity. Existing studies on CTF exercises...examined either how they benefit learning, or are best conducted. To our knowledge, no formal study has yet looked at the relationship between the

Multi-criteria decision making to support waste management: A critical review of current practices and methods.

Science.gov (United States)

Goulart Coelho, Lineker M; Lange, Liséte C; Coelho, Hosmanny Mg

2017-01-01

Solid waste management is a complex domain involving the interaction of several dimensions; thus, its analysis and control impose continuous challenges for decision makers. In this context, multi-criteria decision-making models have become important and convenient supporting tools for solid waste management because they can handle problems involving multiple dimensions and conflicting criteria. However, the selection of the multi-criteria decision-making method is a hard task since there are several multi-criteria decision-making approaches, each one with a large number of variants whose applicability depends on information availability and the aim of the study. Therefore, to support researchers and decision makers, the objectives of this article are to present a literature review of multi-criteria decision-making applications used in solid waste management, offer a critical assessment of the current practices, and provide suggestions for future works. A brief review of fundamental concepts on this topic is first provided, followed by the analysis of 260 articles related to the application of multi-criteria decision making in solid waste management. These studies were investigated in terms of the methodology, including specific steps such as normalisation, weighting, and sensitivity analysis. In addition, information related to waste type, the study objective, and aspects considered was recorded. From the articles analysed it is noted that studies using multi-criteria decision making in solid waste management are predominantly addressed to problems related to municipal solid waste involving facility location or management strategy.

Validation of proposed diagnostic criteria (the "Budapest Criteria") for Complex Regional Pain Syndrome.

Science.gov (United States)

Harden, R Norman; Bruehl, Stephen; Perez, Roberto S G M; Birklein, Frank; Marinus, Johan; Maihofner, Christian; Lubenow, Timothy; Buvanendran, Asokumar; Mackey, Sean; Graciosa, Joseph; Mogilevski, Mila; Ramsden, Christopher; Chont, Melissa; Vatine, Jean-Jacques

2010-08-01

Current IASP diagnostic criteria for CRPS have low specificity, potentially leading to overdiagnosis. This validation study compared current IASP diagnostic criteria for CRPS to proposed new diagnostic criteria (the "Budapest Criteria") regarding diagnostic accuracy. Structured evaluations of CRPS-related signs and symptoms were conducted in 113 CRPS-I and 47 non-CRPS neuropathic pain patients. Discriminating between diagnostic groups based on presence of signs or symptoms meeting IASP criteria showed high diagnostic sensitivity (1.00), but poor specificity (0.41), replicating prior work. In comparison, the Budapest clinical criteria retained the exceptional sensitivity of the IASP criteria (0.99), but greatly improved upon the specificity (0.68). As designed, the Budapest research criteria resulted in the highest specificity (0.79), again replicating prior work. Analyses indicated that inclusion of four distinct CRPS components in the Budapest Criteria contributed to enhanced specificity. Overall, results corroborate the validity of the Budapest Criteria and suggest they improve upon existing IASP diagnostic criteria for CRPS. Copyright (c) 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Superstring field theories on super-flag manifolds: superdiff S1/S1 and superdiff S1/super S1

International Nuclear Information System (INIS)

Zhao Zhiyong; Wu, Ke; Saito, Takesi

1987-01-01

We generalize the geometric approach of Bowick and Rajeev [BR] to superstring field theories. The anomaly is identified with nonvanishing of the Ricci curvature of the super-flag manifold. We explicitly calculate the curvatures of superdiff S 1 /S 1 and superdiff S 1 /superS 1 using super-Toeplitz operator techniques. No regularization is needed in this formalism. The critical dimension D=10 is rediscovered as a result of vanishing curvature of the product bundle over the super-flag manifold. (orig.)

38 CFR 1.9 - Description, use, and display of VA seal and flag.

Science.gov (United States)

2010-07-01

... stars represent the five branches of military service. The crossed flags represent our nation's history... employees. (D) Official VA signs. (E) Official publications or graphics issued by and attributed to VA, or...) Souvenir or novelty items. (iii) Toys or commercial gifts or premiums. (iv) Letterhead design, except on...

The readmission risk flag: using the electronic health record to automatically identify patients at risk for 30-day readmission.

Science.gov (United States)

Baillie, Charles A; VanZandbergen, Christine; Tait, Gordon; Hanish, Asaf; Leas, Brian; French, Benjamin; Hanson, C William; Behta, Maryam; Umscheid, Craig A

2013-12-01

Identification of patients at high risk for readmission is a crucial step toward improving care and reducing readmissions. The adoption of electronic health records (EHR) may prove important to strategies designed to risk stratify patients and introduce targeted interventions. To develop and implement an automated prediction model integrated into our health system's EHR that identifies on admission patients at high risk for readmission within 30 days of discharge. Retrospective and prospective cohort. Healthcare system consisting of 3 hospitals. All adult patients admitted from August 2009 to September 2012. An automated readmission risk flag integrated into the EHR. Thirty-day all-cause and 7-day unplanned healthcare system readmissions. Using retrospective data, a single risk factor, ≥ 2 inpatient admissions in the past 12 months, was found to have the best balance of sensitivity (40%), positive predictive value (31%), and proportion of patients flagged (18%), with a C statistic of 0.62. Sensitivity (39%), positive predictive value (30%), proportion of patients flagged (18%), and C statistic (0.61) during the 12-month period after implementation of the risk flag were similar. There was no evidence for an effect of the intervention on 30-day all-cause and 7-day unplanned readmission rates in the 12-month period after implementation. An automated prediction model was effectively integrated into an existing EHR and identified patients on admission who were at risk for readmission within 30 days of discharge. © 2013 Society of Hospital Medicine.

Identifying criteria for multimodel software process improvement solutions : based on a review of current problems and initiatives

NARCIS (Netherlands)

Kelemen, Z.D.; Kusters, R.J.; Trienekens, J.J.M.

2012-01-01

In this article, we analyze current initiatives in multimodel software process improvement and identify criteria for multimodel solutions. With multimodel, we mean the simultaneous usage of more than one quality approach (e.g. standards, methods, techniques to improve software processes). This paper

Algorithms on Flag Manifolds for Knowledge Discovery in N-way Arrays

Science.gov (United States)

2015-11-20

subspace representations. For instance, the d- dimensional subspace in the flag corresponds to the extrinsic manifold mean. When the set of subspaces is...one-dimensional subspace of V and let θ(L, Vi) denote the principal angle between L and Vi. Motivated by a problem in data analysis, we seek an L that...appear less frequently in the literature may be more appropriate for certain tasks. The extrinsic manifold mean, the L 2-median, and the ag mean are

Expert knowledge for automatic detection of bullies in social networks

NARCIS (Netherlands)

Dadvar, M.; Trieschnigg, Rudolf Berend; de Jong, Franciska M.G.

2013-01-01

Cyberbullying is a serious social problem in online environments and social networks. Current approaches to tackle this problem are still inadequate for detecting bullying incidents or to flag bullies. In this study we used a multi-criteria evaluation system to obtain a better understanding of

An unusual case of seed dispersal in an invasive aquatic; yellow flag iris (Iris pseudacorus)

Science.gov (United States)

Understanding reproductive mode of invasive plants can help managers plan more efficacious control. Invasive aquatics typically reproduce primarily through vegetative means. Yellow flag iris is an invasive plant species often growing as an emergent aquatic. There have been contradictory reports of i...

Review of Current Criteria of Spent Fuel Rod Integrity during Dry Storage

International Nuclear Information System (INIS)

Yang, Yong Sik; Kim, Sun Ki; Bang, Je Geon; Song, Kun Woo

2006-01-01

A PWR spent fuel has been stored in a wet storage pool in Korea. However, the amount of spent fuel is expected to exceed the capacity of a wet storage pool within 10∼15 years. From the early 1970's, a research on the PWR spent fuel dry storage started because the dry storage system has been economical compared with the wet storage system. The dry storage technology for Zircaloy-clad fuel was assessed and licensed in many countries such as USA, Canada, FRG and Switzerland. In the dry storage system, a clad temperature may be higher than in the wet storage system and can reach up to 400 .deg.. A higher clad temperature can cause cladding failures during the period of dry storage, and thus a dry storage related research has essentially dealt with the prevention of clad degradation. It is temperature and rod internal pressure that cause cladding failures through the mechanisms such as clad creep rupture, hydride re-orientation, and stress-corrosion cracking etc.. In this paper, the current licensing criteria are summarized for the PWR spent fuel dry storage system, especially on spent fuel rod integrity. And it is investigated that an application propriety of existing criteria to Korea spent fuel dry storage system

Repository operational criteria analysis

International Nuclear Information System (INIS)

Hageman, J.P.; Chowdhury, A.H.

1992-08-01

The objective of the ''Repository Operational Criteria (ROC) Feasibility Studies'' (or ROC task) was to conduct comprehensive and integrated analyses of repository design, construction, and operations criteria in 10 CFR Part 60 regulations, considering the interfaces and impacts of any potential changes to those regulations. The study addresses regulatory criteria related to the preclosure aspects of the geologic repository. The study task developed regulatory concepts or potential repository operational criteria (PROC) based on analysis of a repository's safety functions and other regulations for similar facilities. These regulatory concepts or PROC were used as a basis to assess the sufficiency and adequacy of the current criteria in 10 CFR Part 60. Where the regulatory concepts were same as current operational criteria, these criteria were referenced. The operations criteria referenced or the PROC developed are given in this report. Detailed analyses used to develop the regulatory concepts and any necessary PROC for those regulations that may require a minor change are also presented. The results of the ROC task showed a need for further analysis and possible major rule change related to the design bases of a geologic repository operations area, siting, and radiological emergency planning

THE FLAG: A Web Resource of Innovative Assessment Tools for Faculty in College Science, Mathematics, Engineering, and Technology

Science.gov (United States)

Zeilik, M.; Mathieu, R. D.; National InstituteScience Education; College Level-One Team

2000-12-01

Even the most dedicated college faculty often discover that their students fail to learn what was taught in their courses and that much of what students do learn is quickly forgotten after the final exam. To help college faculty improve student learning in college Science, Mathematics, Engineering and Technology (SMET), the College Level - One Team of the National Institute for Science Education has created the "FLAG" a Field-tested Learning Assessment Guide for SMET faculty. Developed with funding from the National Science Foundation, the FLAG presents in guidebook format a diverse and robust collection of field-tested classroom assessment techniques (CATs), with supporting information on how to apply them in the classroom. Faculty can download the tools and techniques from the website, which also provides a goals clarifier, an assessment primer, a searchable database, and links to additional resources. The CATs and tools have been reviewed by an expert editorial board and the NISE team. These assessment strategies can help faculty improve the learning environments in their SMET courses especially the crucial introductory courses that most strongly shape students' college learning experiences. In addition, the FLAG includes the web-based Student Assessment of Learning Gains. The SALG offers a convenient way to evaluate the impact of your courses on students. It is based on findings that students' estimates of what they gained are more reliable and informative than their observations of what they liked about the course or teacher. It offers accurate feedback on how well the different aspects of teaching helped the students to learn. Students complete the SALG online after a generic template has been modified to fit the learning objectives and activities of your course. The results are presented to the teacher as summary statistics automatically. The FLAG can be found at the NISE "Innovations in SMET Education" website at www.wcer.wisc.edu/nise/cl1

U.S. BICENTENNIAL EXPOSITION & PAINTING OF AMERICAN FLAG ON VAB

Science.gov (United States)

1976-01-01

Transformation of the U. S. Bicentennial on Science and Technology from an artist's concept to reality is well underway at KSC. At lower right are stages of the Saturn V rocket which will form part of the Exposition. Four of the 15 domes erected to house exhibits by 16 federal agencies and numerous industrial firms are visible in the foreground. At left center, workmen on a scaffold can be seen completing the blue field on the American flag being painted on the Vehicle Assembly Building. The Exposition will be open to the public from May 30 through September 7.

Extrapolating power-ramp performance criteria for current and advanced CANDU fuels

Energy Technology Data Exchange (ETDEWEB)

Tayal, M.; Chassie, G.G

2000-06-01

To improve the precision and accuracy of power-ramp performance criteria for high-burnup fuel, we have examined in-reactor fuel performance data as well as out-reactor test data. The data are consistent with some of the concepts used in the current formulations for defining fuel failure thresholds, such as size of power-ramp and extent of burnup. Our review indicates that there is a need to modify some other aspects of the current formulations; therefore, a modified formulation is presented in this paper. The improvements mainly concern corrodent concentration and its relationships with threshold stress for failure. The new formulation is consistent with known and expected trends such as strength of Zircaloy in corrosive environment, timing of the release of fission products to the pellet-to-sheath gap, CANLUB coating, and fuel burnup. Because of the increased precision and accuracy, the new formulation is better able to identify operational regimes that are at risk of power-ramp failures; this predictive ability provides enhanced protection to fuel against power-ramp defects. At die same time, by removing unnecessary conservatisms in other areas, the new formulation permits a greater range of defect-free operational envelope as well as larger operating margins in regions that are, in fact, not prone to power-ramp failures. (author)

76 FR 1665 - Stakeholder Meetings Regarding the U.S.-Flag Great Lakes Fleet Revitalization Study; Correction

Science.gov (United States)

2011-01-11

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2010-0111] Stakeholder Meetings Regarding the U.S.-Flag Great Lakes Fleet Revitalization Study; Correction AGENCY: Maritime Administration, Department of Transportation. ACTION: Correction Notice. SUMMARY: On December 29, 2010, at 75 FR...

Flagging optically shallow pixels for improved analysis of ocean color data

Science.gov (United States)

McKinna, L. I. W.; Werdell, J.; Knowles, D., Jr.

2016-02-01

Ocean color remote-sensing is routinely used to derive marine geophysical parameters from sensor-observed water-leaving radiances. However, in clear geometrically shallow regions, traditional ocean color algorithms can be confounded by light reflected from the seafloor. Such regions are typically referred to as "optically shallow". When performing spatiotemporal analyses of ocean color datasets, optically shallow features such as coral reefs can lead to unexpected regional biases. Benthic contamination of the water-leaving radiance is dependent on bathymetry, water clarity and seafloor albedo. Thus, a prototype ocean color processing flag called OPTSHAL has been developed that takes all three variables into account. In the method described here, the optical depth of the water column at 547 nm, ζ(547), is predicted from known bathymetry and estimated inherent optical properties. If ζ(547) is less then the pre-defined threshold, a pixel is flagged as optically shallow. Radiative transfer modeling was used to identify the appropriate threshold value of ζ(547) for a generic benthic sand albedo. OPTSHAL has been evaluated within the NASA Ocean Biology Processing Group's L2GEN code. Using MODIS Aqua imagery, OPTSHAL was tested in two regions: (i) the Pedro Bank south-west of Jamaica, and (ii) the Great Barrier Reef, Australia. It is anticipated that OPTSHAL will benefit end-users when quality controlling derived ocean color products. Further, OPTSHAL may prove useful as a mechanism for switching between optically deep and shallow algorithms during ocean color processing.

Red flags to screen for malignancy and fracture in patients with low back pain : systematic review

NARCIS (Netherlands)

Downie, Aron; Williams, Christopher M.; Henschke, Nicholas; Hancock, Mark J.; Ostelo, Raymond W J G; de Vet, Henrica C W; Macaskill, Petra; Irwig, Les; van Tulder, Maurits W; Koes, Bart W; Maher, Christopher G.

2013-01-01

OBJECTIVE: To review the evidence on diagnostic accuracy of red flag signs and symptoms to screen for fracture or malignancy in patients presenting with low back pain to primary, secondary, or tertiary care. DESIGN: Systematic review. DATA SOURCES: Medline, OldMedline, Embase, and CINAHL from

Psychometric Analysis of the Systematic Observation of Red Flags for Autism Spectrum Disorder in Toddlers

Science.gov (United States)

Dow, Deanna; Guthrie, Whitney; Stronach, Sheri T.; Wetherby, Amy M.

2017-01-01

The purpose of this study was to examine the utility of the Systematic Observation of Red Flags as an observational level-two screening measure to detect risk for autism spectrum disorder in toddlers when used with a video-recorded administration of the Communication and Symbolic Behavior Scales. Psychometric properties of the Systematic…

49 CFR 214.521 - Flagging equipment for on-track roadway maintenance machines and hi-rail vehicles.

Science.gov (United States)

2010-10-01

... maintenance machines and hi-rail vehicles. 214.521 Section 214.521 Transportation Other Regulations Relating... WORKPLACE SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles § 214.521 Flagging equipment for on-track roadway maintenance machines and hi-rail vehicles. Each on-track roadway maintenance machine...

38 CFR 1.10 - Eligibility for and disposition of the United States flag for burial purposes.

Science.gov (United States)

2010-07-01

... separation from such service under conditions other than dishonorable, on or after April 25, 1951. (Authority... issued a flag on application signed by guardian). (iii) Parents, including adoptive, stepparents, and foster parents. (iv) Brothers or sisters, including brothers or sisters of the halfblood. (v) Uncles or...

Descent of line bundles to GIT quotients of flag varieties by maximal torus

OpenAIRE

Kumar, Shrawan

2007-01-01

Let L be a homogeneous ample line bundle on any flag variety G/P and let T be a maximal torus of G. We prove a general necessary and sufficient condition for L to descend as a line bundle on the GIT quotient of G/P by T. We use this result to explicitly determine exactly which L descend to the GIT quotient for any simple complex algebraic group G and any parabolic subgroup P.

Prevalence and Red Flags Regarding Specified Causes of Back Pain in Older Adults Presenting in General Practice

NARCIS (Netherlands)

Enthoven, Wendy T. M.; Geuze, Judith; Scheele, Jantine; Bierma-Zeinstra, Sita M. A.; Bueving, Herman J.; Bohnen, Arthur M.; Peul, Wilco C.; van Tulder, Maurits W.; Berger, Marjolein Y.; Koes, Bart W.; Luijsterburg, Pim A. J.

BACKGROUND: In a small proportion of patients experiencing unspecified back pain a specified underlying pathology is present. OBJECTIVE: To identify the prevalence of physician-specified causes of back pain and to assess associations between red flags and vertebral fractures, as diagnosed by the

Flag varieties, toric varieties, and suspensions: Three instances of infinite transitivity

International Nuclear Information System (INIS)

Arzhantsev, Ivan V; Zaidenberg, M G; Kuyumzhiyan, Karine G

2012-01-01

We say that a group G acts infinitely transitively on a set X if for every m element of N the induced diagonal action of G is transitive on the cartesian mth power X m backslash Δ with the diagonals removed. We describe three classes of affine algebraic varieties such that their automorphism groups act infinitely transitively on their smooth loci. The first class consists of normal affine cones over flag varieties, the second of nondegenerate affine toric varieties, and the third of iterated suspensions over affine varieties with infinitely transitive automorphism groups. Bibliography: 42 titles.

FLAG-induced remission in a patient with acute mast cell leukemia (MCL exhibiting t(7;10(q22;q26 and KIT D816H

Directory of Open Access Journals (Sweden)

Peter Valent

2014-01-01

Full Text Available Mast cell leukemia (MCL is a life-threatening disease associated with high mortality and drug-resistance. Only few patients survive more than 12 months. We report on a 55-year-old female patient with acute MCL diagnosed in May 2012. The disease was characterized by a rapid increase in white blood cells and mast cells (MC in the peripheral blood, and a rapid increase of serum tryptase levels. The KIT D816H mutation was detected in the blood and bone marrow (BM. Induction chemotherapy with high-dose ARA-C and fludarabine (FLAG was administered. Unexpectedly, the patient entered a hematologic remission with almost complete disappearance of neoplastic MC and a decrease of serum tryptase levels to normal range after 2 cycles of FLAG. Consecutively, the patient was prepared for allogeneic stem cell transplantation. However, shortly after the third cycle of FLAG, tryptase levels increased again, immature MC appeared in the blood, and the patient died from cerebral bleeding. Together, this case shows that intensive chemotherapy regimens, like FLAG, may induce remission in acute MCL. However, treatment responses are short-lived and the overall outcome remains dismal in these patients. We propose to separate this acute type of MCL from more subacute or chronic variants of MCL.

The rescue and evaluation of FLAG and HIS epitope-tagged Asia 1 type foot-and-mouth disease viruses.

Science.gov (United States)

Yang, Bo; Yang, Fan; Zhang, Yan; Liu, Huanan; Jin, Ye; Cao, Weijun; Zhu, Zixiang; Zheng, Haixue; Yin, Hong

2016-02-02

The VP1 G-H loop of the foot-and-mouth disease virus (FMDV) contains the primary antigenic site, as well as an Arg-Gly-Asp (RGD) binding motif for the αv-integrin family of cell surface receptors. We anticipated that introducing a foreign epitope tag sequence downstream of the RGD motif would be tolerated by the viral capsid and would not destroy the antigenic site of FMDV. In this study, we have designed, generated, and characterized two recombinant FMDVs with a FLAG tag or histidine (HIS) inserted in the VP1 G-H loop downstream of the RGD motif +9 position. The tagged viruses were genetically stable and exhibited similar growth properties with their parental virus. What is more, the recombinant viruses rFMDV-FLAG and rFMDV-HIS showed neutralization sensitivity to FMDV type Asia1-specific mAbs, as well as to polyclonal antibodies. Additionally, the r1 values of the recombinant viruses were similar to that of the parental virus, indicating that the insertion of FLAG or HIS tag sequences downstream of the RGD motif +9 position do not eradicate the antigenic site of FMDV and do not affect its antigenicity. These results indicated that the G-H loop of Asia1 FMDV is able to effectively display the foreign epitopes, making this a potential approach for novel FMDV vaccines development. Copyright © 2015 Elsevier B.V. All rights reserved.

The Savannah River site`s groundwater monitoring program: second quarter 1997

Energy Technology Data Exchange (ETDEWEB)

Rogers, C.D. [Westinghouse Savannah River Company, AIKEN, SC (United States)

1997-11-01

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site`s (SRS) Groundwater Monitoring Program. During second quarter 1997, EPD/EMS conducted extensive sampling of monitoring wells. A detailed explanation of the flagging criteria is presented in the Flagging Criteria section of this document. Analytical results from second quarter 1997 are included in this report.

Adaptation of PyFlag to Efficient Analysis of Overtaken Computer Data Storage

Directory of Open Access Journals (Sweden)

Aleksander Byrski

2010-03-01

Full Text Available Based on existing software aimed at investigation support in the analysis of computer data storage overtaken during investigation (PyFlag, an extension is proposed involving the introduction of dedicated components for data identification and filtering. Hash codes for popular software contained in NIST/NSRL database are considered in order to avoid unwanted files while searching and to classify them into several categories. The extension allows for further analysis, e.g. using artificial intelligence methods. The considerations are illustrated by the overview of the system's design.

Making Good Decisions in Healthcare with Multi-Criteria Decision Analysis: The Use, Current Research and Future Development of MCDA.

Science.gov (United States)

Mühlbacher, Axel C; Kaczynski, Anika

2016-02-01

Healthcare decision making is usually characterized by a low degree of transparency. The demand for transparent decision processes can be fulfilled only when assessment, appraisal and decisions about health technologies are performed under a systematic construct of benefit assessment. The benefit of an intervention is often multidimensional and, thus, must be represented by several decision criteria. Complex decision problems require an assessment and appraisal of various criteria; therefore, a decision process that systematically identifies the best available alternative and enables an optimal and transparent decision is needed. For that reason, decision criteria must be weighted and goal achievement must be scored for all alternatives. Methods of multi-criteria decision analysis (MCDA) are available to analyse and appraise multiple clinical endpoints and structure complex decision problems in healthcare decision making. By means of MCDA, value judgments, priorities and preferences of patients, insurees and experts can be integrated systematically and transparently into the decision-making process. This article describes the MCDA framework and identifies potential areas where MCDA can be of use (e.g. approval, guidelines and reimbursement/pricing of health technologies). A literature search was performed to identify current research in healthcare. The results showed that healthcare decision making is addressing the problem of multiple decision criteria and is focusing on the future development and use of techniques to weight and score different decision criteria. This article emphasizes the use and future benefit of MCDA.

Use of the RoboFlag synthetic task environment to investigate workload and stress responses in UAV operation.

Science.gov (United States)

Guznov, Svyatoslav; Matthews, Gerald; Funke, Gregory; Dukes, Allen

2011-09-01

Use of unmanned aerial vehicles (UAVs) is an increasingly important element of military missions. However, controlling UAVs may impose high stress and workload on the operator. This study evaluated the use of the RoboFlag simulated environment as a means for profiling multiple dimensions of stress and workload response to a task requiring control of multiple vehicles (robots). It tested the effects of two workload manipulations, environmental uncertainty (i.e., UAV's visual view area) and maneuverability, in 64 participants. The findings confirmed that the task produced substantial workload and elevated distress. Dissociations between the stress and performance effects of the manipulations confirmed the utility of a multivariate approach to assessment. Contrary to expectations, distress and some aspects of workload were highest in the low-uncertainty condition, suggesting that overload of information may be an issue for UAV interface designers. The strengths and limitations of RoboFlag as a methodology for investigating stress and workload responses are discussed.

The Savannah River Site`s groundwater monitoring program. Third quarter 1990

Energy Technology Data Exchange (ETDEWEB)

1991-05-06

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site`s (SRS) Groundwater Monitoring Program. During third quarter 1990 (July through September) EPD/EMS conducted routine sampling of monitoring wells and drinking water locations. EPD/EMS established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria do not define contamination levels; instead they aid personnel in sample scheduling, interpretation of data, and trend identification. The flagging criteria are based on detection limits, background levels in SRS groundwater, and drinking water standards. All analytical results from third quarter 1990 are listed in this report, which is distributed to all site custodians. One or more analytes exceeded Flag 2 in 87 monitoring well series. Analytes exceeded Flat 2 for the first since 1984 in 14 monitoring well series. In addition to groundwater monitoring, EPD/EMS collected drinking water samples from SRS drinking water systems supplied by wells. The drinking water samples were analyzed for radioactive constituents.

The Savannah River Site's groundwater monitoring program

International Nuclear Information System (INIS)

1991-01-01

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site's (SRS) Groundwater Monitoring Program. During third quarter 1990 (July through September) EPD/EMS conducted routine sampling of monitoring wells and drinking water locations. EPD/EMS established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria do not define contamination levels; instead they aid personnel in sample scheduling, interpretation of data, and trend identification. The flagging criteria are based on detection limits, background levels in SRS groundwater, and drinking water standards. All analytical results from third quarter 1990 are listed in this report, which is distributed to all site custodians. One or more analytes exceeded Flag 2 in 87 monitoring well series. Analytes exceeded Flat 2 for the first since 1984 in 14 monitoring well series. In addition to groundwater monitoring, EPD/EMS collected drinking water samples from SRS drinking water systems supplied by wells. The drinking water samples were analyzed for radioactive constituents

Operators work reliability current control based on the psychological and physiological criteria

International Nuclear Information System (INIS)

Karpenko, A.V.; Burov, A.Yu.; Grigorus', A.G.; Kal'nish, V.V.; Kapshuk, A.P.; Grigor'yants, T.N.; Bobko, N.A.

1984-01-01

A possibility of developing highly sensitive criteria for assessment of mental working ability at the expense of profound automated analysis of available psychological and physiological criteria is disclosed; it is a precondition for developing operator is woAking ability control system not requiring additional personnel for its operation

Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models.

Science.gov (United States)

Uebbing, Lukas; Klumpp, Lukas; Webster, Gregory K; Löbenberg, Raimar

2017-01-01

Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration testing, the mentioned criteria are not globally accepted. This study provides scientific justification for using disintegration testing rather than dissolution testing as a quality control method for certain immediate release (IR) formulations. A mechanistic approach, which is beyond the current FDA criteria, is presented. Dissolution testing via United States Pharmacopeial Convention Apparatus II at various paddle speeds was performed for immediate and extended release formulations of metronidazole. Dissolution profile fitting via DDSolver and dissolution profile predictions via DDDPlus™ were performed. The results showed that Fickian diffusion and drug particle properties (DPP) were responsible for the dissolution of the IR tablets, and that formulation factors (eg, coning) impacted dissolution only at lower rotation speeds. Dissolution was completely formulation controlled if extended release tablets were tested and DPP were not important. To demonstrate that disintegration is the most important dosage form attribute when dissolution is DPP controlled, disintegration, intrinsic dissolution and dissolution testing were performed in conventional and disintegration impacting media (DIM). Tablet disintegration was affected by DIM and model fitting to the Korsmeyer-Peppas equation showed a growing effect of the formulation in DIM. DDDPlus was able to predict tablet dissolution and the intrinsic dissolution profiles in conventional media and DIM. The study showed that disintegration has to occur before DPP-dependent dissolution can happen. The study suggests that

75 FR 13654 - Use of Foreign-Flag Anchor Handling Vessels in the Beaufort Sea or Chukchi Sea Adjacent to Alaska

Science.gov (United States)

2010-03-22

... submitted by hand or by mail to the Docket Clerk, U.S. DOT Dockets, Room PL-401, Department of... handling vessel adjacent to the coast of Alaska. The foreign-flag anchor handling vessel (TOR VIKING...

Flag leaf photosynthesis and stomatal function of grain sorghum as influenced by changing photosynthetic photon flux densities

Science.gov (United States)

Data on physiological parameters of A, gs, Em, Ci, and IWUE in grain sorghum (Sorghum bicolor L. Moench) is limited. Flag leaves from three plants of two hybrids, grown using added N fertilizer rates of 0.0, 112, and 224 kg ha-1 near Elizabeth, MS were field sampled for these parameters at growth s...

[PS II photochemical efficiency in flag leaf of wheat varieties and its adaptation to strong sun- light intensity on farmland of Xiangride in Qinghai Province, Northwest China].

Science.gov (United States)

Shi, Sheng-Bo; Chen, Wen-Jie; Shi, Rui; Li, Miao; Zhang, Huai-Gang; Sun, Ya-Nan

2014-09-01

Taking four wheat varieties developed by Northwest Institute of Plateau Biology, Chinese Academy of Sciences, as test materials, with the measurement of content of photosynthetic pigments, leaf area, fresh and dry mass of flag leaf, the PS II photochemistry efficiency of abaxial and adaxial surface of flag leaf and its adaptation to strong solar radiation during the period of heading stage in Xiangride region were investigated with the pulse-modulated in-vivo chlorophyll fluorescence technique. The results indicated that flag leaf angle mainly grew in horizontal state in Gaoyuan 314, Gaoyuan 363 and Gaoyuan 584, and mainly in vertical state in Gaoyuan 913 because of its smaller leaf area and larger width. Photosynthetic pigments were different among the 4 varieties, and positively correlated with intrinsic PS II photochemistry efficiencies (Fv/Fm). In clear days, especially at noon, the photosynthetic photoinhibition was more serious in abaxial surface of flag leaf due to directly facing the solar radiation, but it could recover after reduction of sunlight intensity in the afternoon, which meant that no inactive damage happened in PS II reaction centers. There were significant differences of PS II actual and maximum photochemical efficiencies at the actinic light intensity (ΦPS II and Fv'/Fm') between abaxial and adaxial surface, and their relative variation trends were on the contrary. The photochemical and non-photochemical quenching coefficients (qP and NPQ) had a similar tendency in both abaxial and adaxial surfaces. Although ΦPS II and qP were lower in adaxial surface of flag leaf, the Fv'/Fm' was significantly higher, which indicated that the potential PS II capture efficiency of excited energy was higher. The results demonstrated that process of photochemical and non-photochemical quenching could effectively dissipate excited energy caused by strong solar radiation, and there were higher adaptation capacities in wheat varieties natively cultivated in

The Savannah River Site's groundwater monitoring program

Energy Technology Data Exchange (ETDEWEB)

1991-05-06

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site's (SRS) Groundwater Monitoring Program. During third quarter 1990 (July through September) EPD/EMS conducted routine sampling of monitoring wells and drinking water locations. EPD/EMS established two sets of flagging criteria in 1986 to assist in the management of sample results. The flagging criteria do not define contamination levels; instead they aid personnel in sample scheduling, interpretation of data, and trend identification. The flagging criteria are based on detection limits, background levels in SRS groundwater, and drinking water standards. All analytical results from third quarter 1990 are listed in this report, which is distributed to all site custodians. One or more analytes exceeded Flag 2 in 87 monitoring well series. Analytes exceeded Flat 2 for the first since 1984 in 14 monitoring well series. In addition to groundwater monitoring, EPD/EMS collected drinking water samples from SRS drinking water systems supplied by wells. The drinking water samples were analyzed for radioactive constituents.

Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes

Energy Technology Data Exchange (ETDEWEB)

Rockel, Beate [Department of Molecular Structural Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried (Germany); Schmaler, Tilo; Huang, Xiaohua [Division of Molecular Biology, Department of General, Visceral, Vascular and Thoracic Surgery, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin (Germany); Dubiel, Wolfgang, E-mail: Wolfgang.dubiel@charite.de [Division of Molecular Biology, Department of General, Visceral, Vascular and Thoracic Surgery, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin (Germany)

2014-07-25

Highlights: • Deneddylation rates of human erythrocyte and mouse fibroblast CSN are very similar. • 3D models of native human and mouse CSN reveal common architectures. • The cryo-structure of native mammalian CSN shows a horseshoe subunit arrangement. - Abstract: The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS, proteins are Ub-labeled for degradation by Ub ligases conferring substrate specificity. The CSN controls a large family of Ub ligases called cullin-RING ligases (CRLs), which ubiquitinate cell cycle regulators, transcription factors and DNA damage response proteins. The CSN possesses structural similarities with the 26S proteasome Lid complex and the translation initiation complex 3 (eIF3) indicating similar ancestry and function. Initial structures were obtained 14 years ago by 2D electron microscopy (EM). Recently, first 3D molecular models of the CSN were created on the basis of negative-stain EM and single-particle analysis, mostly with recombinant complexes. Here, we compare deneddylating activity and structural features of CSN complexes purified in an elaborate procedure from human erythrocytes and efficiently pulled down from mouse Flag-CSN2 B8 fibroblasts. In an in vitro deneddylation assay both the human and the mouse CSN complexes deneddylated Nedd8-Cul1 with comparable rates. 3D structural models of the erythrocyte CSN as well as of the mouse Flag-CSN were generated by negative stain EM and by cryo-EM. Both complexes show a central U-shaped segment from which several arms emanate. This structure, called the horseshoe, is formed by the PCI domain subunits. CSN5 and CSN6 point away from the horseshoe. Compared to 3D models of negatively stained CSN complexes, densities assigned to CSN2 and CSN4 are better defined in the cryo-map. Because biochemical and structural results obtained with CSN complexes isolated from human erythrocytes and purified by Flag-CSN pulldown from mouse B8 fibroblasts

Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes

International Nuclear Information System (INIS)

Rockel, Beate; Schmaler, Tilo; Huang, Xiaohua; Dubiel, Wolfgang

2014-01-01

Highlights: • Deneddylation rates of human erythrocyte and mouse fibroblast CSN are very similar. • 3D models of native human and mouse CSN reveal common architectures. • The cryo-structure of native mammalian CSN shows a horseshoe subunit arrangement. - Abstract: The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS, proteins are Ub-labeled for degradation by Ub ligases conferring substrate specificity. The CSN controls a large family of Ub ligases called cullin-RING ligases (CRLs), which ubiquitinate cell cycle regulators, transcription factors and DNA damage response proteins. The CSN possesses structural similarities with the 26S proteasome Lid complex and the translation initiation complex 3 (eIF3) indicating similar ancestry and function. Initial structures were obtained 14 years ago by 2D electron microscopy (EM). Recently, first 3D molecular models of the CSN were created on the basis of negative-stain EM and single-particle analysis, mostly with recombinant complexes. Here, we compare deneddylating activity and structural features of CSN complexes purified in an elaborate procedure from human erythrocytes and efficiently pulled down from mouse Flag-CSN2 B8 fibroblasts. In an in vitro deneddylation assay both the human and the mouse CSN complexes deneddylated Nedd8-Cul1 with comparable rates. 3D structural models of the erythrocyte CSN as well as of the mouse Flag-CSN were generated by negative stain EM and by cryo-EM. Both complexes show a central U-shaped segment from which several arms emanate. This structure, called the horseshoe, is formed by the PCI domain subunits. CSN5 and CSN6 point away from the horseshoe. Compared to 3D models of negatively stained CSN complexes, densities assigned to CSN2 and CSN4 are better defined in the cryo-map. Because biochemical and structural results obtained with CSN complexes isolated from human erythrocytes and purified by Flag-CSN pulldown from mouse B8 fibroblasts

Qualitative vs. quantitative atopic dermatitis criteria

DEFF Research Database (Denmark)

Andersen, R M; Thyssen, J P; Maibach, H I

2016-01-01

This review summarizes historical aspects, clinical expression and pathophysiology leading to coining of the terms atopy and atopic dermatitis, current diagnostic criteria and further explore the possibility of developing quantitative diagnostic criteria of atopic dermatitis (AD) based on the imp...

The temporal and species dynamics of photosynthetic acclimation in flag leaves of rice (Oryza sativa) and wheat (Triticum aestivum) under elevated carbon dioxide

Energy Technology Data Exchange (ETDEWEB)

Zhu, J.; Zeng, Q.; Xie, Z.; Tang, H.; Zhu, C. (Chinese Academy of Sciences. State Key Lab. of Soil and Sustainable Agriculture, Institute of Soil Science, Nanjing (China)); Hasegawa, T. (National Institute for Agro-Environmental Sciences. Agro-Meteorology Div., Tsukuba (Japan)); Ziska, L. (Crop Systems and Global Change Lab., Beltsville, MD (United States)); Jia, X. (Chinese Academic of Sciences/Nanjing Botanical Garden Memorial Sun Yat-Sen. Jiangsu Institute of Botany, Nanjing (China))

2012-07-15

In this study, we tested for the temporal occurrence of photosynthetic acclimation to elevated [CO{sub 2}] in the flag leaf of two important cereal crops, rice and wheat. In order to characterize the temporal onset of acclimation and the basis for any observed decline in photosynthetic rate, we characterized net photosynthesis, g{sub s}, g{sub m}, C{sub i}/C{sub a}, C{sub i}/C{sub c}, V{sub cmax}, J{sub max}, cell wall thickness, content of Rubisco, cytochrome (Cyt) f, N, chlorophyll and carbohydrate, mRNA expression for rbcL and petA, activity for Rubisco, sucrose phosphate synthase (SPS) and sucrose synthase (SS) at full flag expansion, mid-anthesis and the late grain-filling stage. No acclimation was observed for either crop at full flag leaf expansion. However, at the mid-anthesis stage, photosynthetic acclimation in rice was associated with RuBP carboxylation and regeneration limitations, while wheat only had the carboxylation limitation. By grain maturation, the decline of Rubisco content and activity had contributed to RuBP carboxylation limitation of photosynthesis in both crops at elevated [CO{sub 2}]; however, the sharp decrease of Rubisco enzyme activity played a more important role in wheat. Although an increase in non-structural carbohydrates did occur during these later stages, it was not consistently associated with changes in SPS and SS or photosynthetic acclimation. Rather, over time elevated [CO{sub 2}] appeared to enhance the rate of N degradation and senescence so that by late-grain fill, photosynthetic acclimation to elevated [CO{sub 2}] in the flag leaf of either species was complete. These data suggest that the basis for photosynthetic acclimation with elevated [CO{sub 2}] may be more closely associated with enhanced rates of senescence, and, as a consequence, may be temporally dynamic, with significant species variation. (Author)

Metabolic syndrome in Black people of the African diaspora: the paradox of current classification, definition and criteria.

Science.gov (United States)

Gaillard, Trudy; Schuster, Dara; Osei, Kwame

2009-01-01

According to the third National Health and Nutrition Examination Survey, African Americans have a lower prevalence of metabolic syndrome than do Whites. Recent reports in Blacks in other regions have confirmed these observations, but the rates vary. This lower rate of metabolic syndrome in Blacks can be partly ascribed to the lower prevalent rates of some major components of metabolic syndrome, namely serum triglyceride and high-density lipoprotein cholesterol levels in Blacks. This is in contrast with the higher prevalence of obesity (waist circumference) and blood pressure that meet National Cholesterol Education Program criteria in Blacks. Despite these seemingly favorable lipids and lipoprotein profiles, Blacks continue to have higher cardiovascular disease (CVD) mortality and morbidity, even in the absence of diabetes, than do Whites. Insulin resistance is more prevalent in Blacks than in Whites. However, the relationships among insulin resistance and CVD risk factors such as hypertension, high-density lipoprotein cholesterol, and triglycerides are weak in contrast with Whites. The paradox of more favorable lipid profile and conversely the higher rates of unfavorable blood pressure in Blacks calls into question the validity of the current criteria for metabolic syndrome in Blacks. Thus, it can be argued that each of the components of the metabolic syndrome carry different CVD risk factors in Blacks. The greater CVD mortality and morbidity in Blacks appear to be multifactorial. With the emerging epidemic of noncommunicable diseases, chronic kidney diseases due to both diabetes and hypertension have emerged as major CVD risks that are associated with increasing mortality and morbidity in Blacks. We need to emphasize specific components of metabolic syndrome, specifically blood pressure and chronic kidney disease, that carry higher CVD risk with associated greater morbidity and mortality for primary prevention of CVD and type 2 diabetes in Blacks. To this end, we

Are the current notification criteria for Lyme borreliosis in Norway suitable? Results of an evaluation of Lyme borreliosis surveillance in Norway, 1995–2013

Directory of Open Access Journals (Sweden)

Emily MacDonald

2016-08-01

Full Text Available Abstract Background The approach to surveillance of Lyme borreliosis varies between countries, depending on the purpose of the surveillance system and the notification criteria used, which prevents direct comparison of national data. In Norway, Lyme borreliosis is notifiable to the Surveillance System for Communicable Diseases (MSIS. The current notification criteria include a combination of clinical and laboratory results for borrelia infection (excluding Erythema migrans but there are indications that these criteria are not followed consistently by clinicians and by laboratories. Therefore, an evaluation of Lyme borreliosis surveillance in Norway was conducted to describe the purpose of the system and to assess the suitability of the current notification criteria in order to identify areas for improvement. Methods The CDC Guidelines for Evaluation of Surveillance Systems were used to develop the assessment of the data quality, representativeness and acceptability of MSIS for surveillance of Lyme borreliosis. Data quality was assessed through a review of data from 1996 to 2013 in MSIS and a linkage of MSIS data from 2008 to 2012 with data from the Norwegian Patient Registry (NPR. Representativeness and acceptability were assessed through a survey sent to 23 diagnostic laboratories. Results Completeness of key variables for cases reported to MSIS was high, except for geographical location of exposureThe NPR-MSIS linkage identified 1047 cases in both registries, while 363 were only reported to MSIS and 3914 were only recorded in NPR. A higher proportion of cases found in both registries were recorded as neuroborreliosis in MSIS (84.4 % than those cases found only in MSIS (20.1 %. The trend (average yearly increase or decrease in reported cases of neuroborreliosis in MSIS was not significantly different from the trend for all other clinical manifestations recorded in MSIS in negative binomial regression (p = 0.3. The 16 surveyed laboratories

Worker flag. Independent Electrical Policy; Bandera Obrera. Politica Electrica Independiente

Energy Technology Data Exchange (ETDEWEB)

Bahen, D [Sindicato Unico de Trabajadores de la Industria Nuclear, Salazar, Estado de Mexico C.P. 52045 (Mexico)

2000-07-01

This work analyses the initiative of privatization of the Mexican Electric Industry and also it is showed the incoherence of this mistaken proposal. Along the same line is analysed tthe situation of the National Electric Sector and the working process for the distinct types of electric generation just as the syndical and labor situations. In consequence it is proposed an Independent Electrical Policy, which includes the integration of the Nationalized Electric Industry, the syndical union and the Unique Collective Contract. The purpose of this work is to contribute to the success of the electrical and nuclear struggle always maintaining in rising position the red flag of the proletariat. The author considers that the privatization means mercantilization of the human necessities. The privatization is not inevitable at condition of to exercise consequently the political actions necessary through alternatives includes: the worker control of production, research, and the National Electric strike. (Author)

Top-level regulatory criteria for the standard MHTGR

Energy Technology Data Exchange (ETDEWEB)

NONE

1986-10-15

The Licensing Plan for the Standard MHTGR (Ref. 1) describes a program to support a U.S. Nuclear Regulatory Commission (NRC) design review and approval. The Plan calls for the submittal of Top-Level Regulatory Criteria to the NRC for concurrence with their completeness and acceptability for the MHTGR program. The Top-Level Regulatory Criteria are defined as the standards for judging licensability that directly specify acceptable limits for protection of the public health and safety and the environment. The criteria proposed herein are for normal plant operation and a broad spectrum of anticipated events, including accidents. The approach taken is to define a set of criteria which are general as opposed to being design specific. Specifically, it is recommended that criteria be met which: 1. Are less prescriptive than current regulation, thereby encouraging maximum flexibility in design approaches. 2. Are measurable. 3. Are not more strict than the criteria for current power plants.

Radiological protection criteria for waste management

International Nuclear Information System (INIS)

Hill, M.D.; Webb, G.A.M.

1985-01-01

In this paper the progress being made by international organisations towards the development of a consensus on the radiological protection criteria to be applied to waste management, and in particular waste disposal, is reviewed. Against this background, work on the development of criteria for use in the UK is described. It is concluded that an international consensus is emerging and that the criteria being recommended for use in the UK are consistent with current international views. (author)

Radiological protection criteria for waste management

International Nuclear Information System (INIS)

Hill, M.D.; Webb, G.A.M.

1985-01-01

In this Paper the progress being made by international organizations towards the development of a consensus on the radiological protection criteria to be applied to waste management, and in particular waste disposal, is reviewed. Against this background, work on the development of criteria for use in the UK is described. It is concluded that an international consensus is emerging and that the criteria being recommended for use in the UK are consistent with current international views. (author)

Impact of radioactivity on the environment: problems, state of current knowledge and approaches for identification of radioprotection criteria

International Nuclear Information System (INIS)

Brechignac, F.

2001-01-01

There is currently a revitalized concern about the potential impact of ionizing radiation on the environment that calls for the construction of a system ensuring an adequate radioprotection of the non-human biota and their associated biotopes. This paper first sets the context of the problem both, with respect to the general philosophy of environmental protection as a whole, but also with respect to the consideration of the environment achieved so far in the purpose of human radioprotection. The current accumulated knowledge on the effects of ionizing radiation to biota (fauna and flora) is then briefly reviewed, encompassing effects at individual and community/ecosystem level, situations of acute and chronic exposure to high and low doses, finally leading to the identification of the most critical gaps in scientific knowledge: effects of mixed low dose rates in chronic exposure to communities and ecosystems. The most significant current international efforts towards the identification of environmental radioprotection criteria and standards are finally presented along with some relevant national examples. (author)

Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models

Directory of Open Access Journals (Sweden)

Uebbing L

2017-04-01

Full Text Available Lukas Uebbing,1,2,* Lukas Klumpp,1,3,* Gregory K Webster,4 Raimar Löbenberg1 1Faculty of Pharmacy and Pharmaceutical Sciences, Katz Group-Rexall Centre for Pharmacy and Health Research, University of Alberta, Edmonton, Canada; 2Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, 3Institute of Pharmaceutical Technology, Goethe University Frankfurt, Frankfurt, Germany; 4Global Research and Development, AbbVie Inc., North Chicago, IL, USA *These authors contributed equally to this work Abstract: Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA has allowed the replacement of dissolution testing with disintegration testing, the mentioned criteria are not globally accepted. This study provides scientific justification for using disintegration testing rather than dissolution testing as a quality control method for certain immediate release (IR formulations. A mechanistic approach, which is beyond the current FDA criteria, is presented. Dissolution testing via United States Pharmacopeial Convention Apparatus II at various paddle speeds was performed for immediate and extended release formulations of metronidazole. Dissolution profile fitting via DDSolver and dissolution profile predictions via DDDPlus™ were performed. The results showed that Fickian diffusion and drug particle properties (DPP were responsible for the dissolution of the IR tablets, and that formulation factors (eg, coning impacted dissolution only at lower rotation speeds. Dissolution was completely formulation controlled if extended release tablets were tested and DPP were not important. To demonstrate that disintegration is the most important dosage form attribute when dissolution is

Current approach to the diagnosis of IgG4-related disease - Combination of comprehensive diagnostic and organ-specific criteria.

Science.gov (United States)

Umehara, Hisanori; Okazaki, Kazuichi; Nakamura, Takuji; Satoh-Nakamura, Tomomi; Nakajima, Akio; Kawano, Mitsuhiro; Mimori, Tsuneyo; Chiba, Tsutomu

2017-05-01

IgG4-related disease (IgG4-RD) is a fascinating clinical entity proposed by Japanese investigators, and includes a wide variety of diseases, formerly diagnosed as Mikulicz's disease (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis, retroperitoneal fibrosis, etc. Although all clinicians in every field of medicine may encounter this new disease, a unifying diagnostic criterion has not been established. In 2011, the Japanese IgG4 team, organized by the Ministry of Health, Labor and Welfare (MHLW) of Japan, published comprehensive diagnostic criteria for IgG4-RD. Several problems with these criteria have arisen in clinical practice, however, including the difficulty obtaining biopsy samples from some patients, and the sensitivity and the specificity of techniques used to measure serum IgG4 concentrations. Although serum IgG4 concentration is an important clinical marker for IgG4-RD, its diagnostic utility in differentiating IgG4-RD from other diseases, called IgG4-RD mimickers, remains unclear. This review describes the current optimal approach for the diagnosis of IgG4-RD, based on both comprehensive and organ-specific diagnostic criteria, in patients with diseases such as IgG4-related pancreatitis (AIP), sclerosing cholangitis, and renal, lung and orbital diseases.

P-Area Acid/Caustic Basin groundwater monitoring report. First quarter 1995

International Nuclear Information System (INIS)

Chase, J.A.

1995-06-01

During first quarter 1995, groundwater from the six PAC monitoring wells at the P-Area Acid/Caustic Basin was analyzed for herbicides/pesticides, indicator parameters, metals, nitrate, adionuclide indicators, and other constituents. Monitoring results that exceeded the final Primary Drinking Water Standards (PDWS) or the Savannah River Site (SRS) flagging criteria or turbidity standard during the quarter are discussed in this report. During first quarter 1995, no constituents exceeded the final PDWS. Aluminum exceeded its SRS Flag 2 criterion in all six PAC wells. Iron and manganese exceeded Flag 2 criteria in three wells, while turbidity was elevated in one well. Groundwater flow direction and rate in the water table beneath the P-Area Acid/Caustic Basin were similar to past quarters

Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

OpenAIRE

Jason, Leonard A; McManimen, Stephanie; Sunnquist, Madison; Newton, Julia L; Strand, Elin Bolle

2017-01-01

The Institute of Medicine (IOM) recently developed clinical criteria for chronic fatigue syndrome (CFS). There might be additional criteria that could select a more homogenous and impaired group of patients, particularly those with pain. The current study focused on criteria which involved meeting the four IOM criteria, excluding medical and psychiatric co-morbidities, along with having fibromyalgia (FM). Findings indicated that those meeting the IOM clinical criteria plus FM were more impair...

Measuring transplant center performance: The goals are not controversial but the methods and consequences can be.

Science.gov (United States)

Jay, Colleen; Schold, Jesse D

2017-03-01

Risks of regulatory scrutiny has generated widespread concern about increasingly risk averse transplant center behaviors regarding both donor and candidate acceptance patterns. To address potential unintended consequences threatening access to care, we discuss recent changes in regulatory metrics and potential improvements in quality oversight of transplant centers. Despite many recent changes to one-year patient and graft survival regulatory criteria, the capacity to accurately identify true underperforming centers and avoiding false positive flagging remains an area of great concern. Numerous studies have demonstrated restrictions in transplant volume and access following transplant center flagging. Current regulatory criteria are limited in their capacity to accurately identify poorly performing centers and potentially encourage risk-averse behavior by transplant centers. Efforts to address these concerns should focus on (1) improving risk-adjustment models with better data which captures the acuity of candidate and donor risk, (2) reconsidering primary outcomes measured to assess comprehensive transplant center performance, (3) improving education to address rational or perceived disincentives, and (4) using data more effectively to share best practices.

Restless Legs Syndrome with Current Diagnostic Criteria

Directory of Open Access Journals (Sweden)

Meral Bilgilisoy Filiz

2015-08-01

Full Text Available Restless legs syndrome (RLS, also known as Willis-Ekbom disease, is a chronic movement disorder, characterized by an urge to move legs usually accompanied by uncomfortable sensations and sleep disorders. The prevalence of the syndrome ranges from 1% to 15% in the general population, and about 2% during childhood. RLS is the most common movement disorder in pregnancy. However RLS still remains underdiagnosed probably due to lack of accurate information about the disease. Family history is positive in 50-70% of the primary RLS patients. The secondary form of the syndrome is associated with iron deficiency, renal failure, pregnancy, diabetes mellitus and many rheumatologic disorders. Secondary forms generally manifest at older ages and have a rapid progression with a poorer prognosis. The pathophysiology of RLS is focused on the dopaminergic system, reduced central nervous system iron levels and genetic linkages. Diagnosis is based on clinical features and the diagnostic criteria suggested by International RLS Study Group. Secondary causes must be carefully investigated before the treatment. In mild forms of the disease non-pharmacologic therapies might be useful, while in moderate or severe forms of the disease generally pharmacologic therapies such as dopamine agonists, anticonvulsants, opioids and benzodiazepines are required. (Turkish Journal of Osteoporosis 2015;21: 87-95

RELEVANCE OF RED FLAGS IN THE EVALUATINH THE RISK OF FINANCIAL STATEMENT FRAUD: PERCEPTIONS OF BRAZILIAN INDEPENDENT AUDITORS

OpenAIRE

Dal-Ri Murcia, Fernando; Borba, José Alonso; Schiehll, Eduardo

2008-01-01

The objective of this paper was to identify perceptions of Brazilian auditors regarding the relevance of red flags in evaluating the risk of fraudulent financial reporting. To accomplish this, a questionnaire was designed using six papers as references: American Institute of Certified Public Accountants (2002), Conselho Federal de Contabilidade (1999), Albrecht and Romney (1986), Eining, Jones and Loebbecke, (1997), Bell and Carcacello (2000) and Wells (2005). Together, these works presented ...

Redefining design criteria for Pu-238 gloveboxes

International Nuclear Information System (INIS)

Acosta, S.V.

1998-01-01

Enclosures for confinement of special nuclear materials (SNM) have evolved into the design of gloveboxes. During the early stages of glovebox technology, established practices and process operation requirements defined design criteria. Proven boxes that performed and met or exceeded process requirements in one group or area, often could not be duplicated in other areas or processes, and till achieve the same success. Changes in materials, fabrication and installation methods often only met immediate design criteria. Standardization of design criteria took a big step during creation of ''Special-Nuclear Materials R and D Laboratory Project, Glovebox standards''. The standards defined design criteria for every type of process equipment in its most general form. Los Alamos National Laboratory (LANL) then and now has had great success with Pu-238 processing. However with ever changing Environment Safety and Health (ES and H) requirements and Ta-55 Facility Configuration Management, current design criteria are forced to explore alternative methods of glovebox design fabrication and installation. Pu-238 fuel processing operations in the Power Source Technologies Group have pushed the limitations of current design criteria. More than half of Pu-238 gloveboxes are being retrofitted or replaced to perform the specific fuel process operations. Pu-238 glovebox design criteria are headed toward process designed single use glovebox and supporting line gloveboxes. Gloveboxes that will house equipment and processes will support TA-55 Pu-238 fuel processing needs into the next century and extend glovebox expected design life

History and Evolution of the Johnson Criteria.

Energy Technology Data Exchange (ETDEWEB)

Sjaardema, Tracy A. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Smith, Collin S. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Birch, Gabriel Carisle [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

2015-07-01

The Johnson Criteria metric calculates probability of detection of an object imaged by an optical system, and was created in 1958 by John Johnson. As understanding of target detection has improved, detection models have evolved to better model additional factors such as weather, scene content, and object placement. The initial Johnson Criteria, while sufficient for technology and understanding at the time, does not accurately reflect current research into target acquisition and technology. Even though current research shows a dependence on human factors, there appears to be a lack of testing and modeling of human variability.

The leak before break criteria, requirements and implications

International Nuclear Information System (INIS)

Martinez M, E.

1992-05-01

Inside this work a general balance is made on the Leak before break approach (LBB), like they are the history and licensing, those limitations, the acceptance criteria of the LBB, the current state of the regulatory development and the current state of it application in countries like E.U.A, Germany, Canada, Italy and France. Everything it with the purpose of evaluating the opportunities that offers the LBB criteria for it possible application in Mexico. (Author)

An Evaluation of the FLAG Friction Model frictmultiscale2 using the Experiments of Juanicotena and Szarynski

Energy Technology Data Exchange (ETDEWEB)

Zocher, Marvin Anthony [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hammerberg, James Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-11-15

The experiments of Juanicotena and Szarynski, namely T101, T102, and T105 are modeled for purposes of gaining a better understanding of the FLAG friction model frictmultiscale2. This exercise has been conducted as a first step toward model validation. It is shown that with inclusion of the friction model in the numerical analysis, the results of Juanicotena and Szarynski are predicted reasonably well. Without the friction model, simulation results do not match the experimental data nearly as well. Suggestions for follow-on work are included.

Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia.

Science.gov (United States)

Jason, Leonard A; McManimen, Stephanie; Sunnquist, Madison; Newton, Julia L; Strand, Elin Bolle

2017-01-01

The Institute of Medicine (IOM) recently developed clinical criteria for chronic fatigue syndrome (CFS). There might be additional criteria that could select a more homogenous and impaired group of patients, particularly those with pain. The current study focused on criteria which involved meeting the four IOM criteria, excluding medical and psychiatric co-morbidities, along with having fibromyalgia (FM). Findings indicated that those meeting the IOM clinical criteria plus FM were more impaired on a wide variety of symptoms and functional areas than those meeting on the IOM criteria or those with just 6 months of fatigue. The implications of using such research criteria are discussed.

Inelastic analysis acceptance criteria for radioactive material transportation containers

International Nuclear Information System (INIS)

Ammerman, D.J.; Ludwigsen, J.S.

1993-01-01

The design criteria currently used in the design of radioactive material (RAM) transportation containers are taken from the ASME Boiler and Pressure Vessel Code (ASME, 1992). These load-based criteria are ideally suited for pressure vessels where the loading is quasistatic and all stresses are in equilibrium with externally applied loads. For impact events, the use of load-based criteria is less supportable. Impact events tend to be energy controlled, and thus, energy-based acceptance criteria would appear to be more appropriate. Determination of an ideal design criteria depends on what behavior is desired. Currently there is not a design criteria for inelastic analysis for RAM nation packages that is accepted by the regulatory agencies. This lack of acceptance criteria is one of the major factors in limiting the use of inelastic analysis. In this paper inelastic analysis acceptance criteria based on stress and strain-energy density will be compared for two stainless steel test units subjected to impacts onto an unyielding target. Two different material models are considered for the inelastic analysis, a bilinear fit of the stress-strain curve and a power law hardening model that very closely follows the stress-strain curve. It is the purpose of this paper to stimulate discussion and research into the area of strain-energy density based inelastic analysis acceptance criteria

Oxytocin increases liking for a country’s people and national flag but not for other cultural symbols or consumer products.

Directory of Open Access Journals (Sweden)

Xiaole eMa

2014-08-01

Full Text Available The neuropeptide oxytocin enhances in-group favoritism and ethnocentrism in males. However, whether such effects also occur in women and extend to national symbols and companies/consumer products is unclear. In a between-subject, double-blind placebo controlled experiment we have investigated the effect of intranasal oxytocin on likeability and arousal ratings given by 51 adult Chinese males and females for pictures depicting people or national symbols/consumer products from both strong and weak in-groups (China and Taiwan and corresponding out-groups (Japan and South Korea. To assess duration of treatment effects subjects were also re-tested after one week. Results showed that although oxytocin selectively increased the bias for overall liking for Chinese social stimuli and the national flag, it had no effect on the similar bias towards other Chinese cultural symbols, companies and consumer products. This enhanced bias was maintained one week after treatment. No overall oxytocin effects were found for Taiwanese, Japanese or South Korean pictures. Our findings show for the first time that oxytocin increases liking for a nation’s society and flag in both men and women, but not that for other cultural symbols or companies/consumer products.

Rett syndrome diagnostic criteria: lessons from the Natural History Study.

Science.gov (United States)

Percy, Alan K; Neul, Jeffrey L; Glaze, Daniel G; Motil, Kathleen J; Skinner, Steven A; Khwaja, Omar; Lee, Hye-Seung; Lane, Jane B; Barrish, Judy O; Annese, Fran; McNair, Lauren; Graham, Joy; Barnes, Katherine

2010-12-01

Analysis of 819 participants enrolled in the Rett syndrome (RTT) Natural History Study validates recently revised diagnostic criteria. 765 females fulfilled 2002 consensus criteria for classic (653/85.4%) or variant (112/14.6%) RTT. All participants classified as classic RTT fulfilled each revised main criterion; supportive criteria were not uniformly present. All variant RTT participants met at least 3 of 6 main criteria in the 2002, 2 of 4 main criteria in the current format, and 5 of 11 supportive criteria in both. This analysis underscores the critical role of main criteria for classic RTT; variant RTT requires both main and supportive criteria.

Fuel safety criteria technical review - Results of OECD/CSNI/PWG2 Task Force on Fuel Safety Criteria

International Nuclear Information System (INIS)

Hollasky, N.; Valtonen, K.; Hache, G.; Gross, H.; Bakker, K.; Recio, M.; Bart, G.; Zimmermann, M.; Van Doesburg, W.; Killeen, J.; Meyer, R.O.; Speis, T.

2000-01-01

With the advent of advanced fuel and core designs, the adoption of more aggressive operational modes and the implementation of more accurate (best estimate or statistical) design and analysis methods, there is a concern if safety margins have remained adequate. Most - if not all - of the currently existing safety criteria were established during the 60's and early 70's, and verified against experiments with fuel that was available at that time, mostly with unirradiated specimens. Verification was of course performed as designs progressed in later years, however mostly with the aim to be able to prove that these designs adequately complied with existing criteria, and not to establish new limits. The OECD/CSNI/PWG2 Task Force on Fuel Safety Criteria (TFFSC) was therefore given the mandate to technically review the existing fuel safety criteria, focusing on the 'new design' elements (new fuel and core design, cladding materials, manufacturing processes, high burnup, MOX, etc.) introduced by the industry. It should also identify if additional efforts may be required (experimental, analytical) to ensure that the basis for fuel safety criteria is adequate to address the relevant safety issues. In this report, fuel-related criteria are discussed without attempting to categorize them according to event type or risk significance. For each of these 20 criteria, we present a brief description of the criterion as it is used in several applications along with the rationale for having such a criterion. New design elements, such as different cladding materials, higher burnup, and the use of MOX fuels, can affect fuel-related margins and, in some cases, the criteria themselves. Some of the more important effects are mentioned in order to indicate whether the criteria need to be re-evaluated. The discussion may not cover all possible effects, but should be sufficient to identify those criteria that need to be addressed. A summary of these discussions is given in Section 7. As part

The prevention of injuries in contact flag football.

Science.gov (United States)

Kaplan, Yonatan; Myklebust, Grethe; Nyska, Meir; Palmanovich, Ezequiel; Victor, Jan; Witvrouw, Erik

2014-01-01

American flag football is a non-tackle, contact sport with many moderate to severe contact-type injuries reported. A previous prospective injury surveillance study by the authors revealed a high incidence of injuries to the fingers, face, knee, shoulder and ankle. The objectives of the study were to conduct a pilot-prospective injury prevention study in an attempt to significantly reduce the incidence and the severity of injuries as compared to a historical cohort, as well as to provide recommendations for a future prospective injury prevention study. A prospective injury prevention study was conducted involving 724 amateur male (mean age: 20.0 ± 3.1 years) and 114 female (mean age: 21.2 ± 7.2 years) players. Four prevention measures were implemented: the no-pocket rule, self-fitting mouth guards, ankle braces (for those players with recurrent ankle sprains) and an injury treatment information brochure. An injury surveillance questionnaire was administered to record all time-loss injuries sustained in game sessions. There was a statistically significant reduction in the number of injured players, the number of finger/hand injuries, the incidence rate and the incidence proportion between the two cohorts (p football. Prevention strategies for a longer, prospective, randomised-controlled injury prevention study should include the strict enforcement of the no-pocket rule, appropriate head gear, the use of comfortable-fitting ankle braces and mouth guards, and changing the blocking rules of the game.

Identification of new SSR markers linked to leaf chlorophyll content, flag leaf senescence and cell membrane stability traits in wheat under water stressed condition.

Science.gov (United States)

Barakat, Mohamed N; Saleh, Mohamed; Al-Doss, Abdullah A; Moustafa, Khaled A; Elshafei, Adel A; Al-Qurainy, Fahed H

2015-03-01

Segregating F4 families from the cross between drought sensitive (Yecora Rojo) and drought tolerant (Pavon 76) genotypes were made to identify SSR markers linked to leaf chlorophyll content, flag leaf senescence and cell membrane stability traits in wheat (Triticum aestivum L.) under water-stressed condition and to map quantitative trait locus (QTL) for the three physiological traits. The parents and 150 F4 families were evaluated phenotypically for drought tolerance using two irrigation treatments (2500 and 7500 m3/ha). Using 400 SSR primers tested for polymorphism in testing parental and F4 families genotypes, the results revealed that QTL for leaf chlorophyll content, flag leaf senescence and cell membrane stability traits were associated with 12, 5 and 12 SSR markers, respectively and explained phenotypic variation ranged from 6 to 42%. The SSR markers for physiological traits had genetic distances ranged from 12.5 to 25.5 cM. These SSR markers can be further used in breeding programs for drought tolerance in wheat.

The risk of coronary heart disease of seafarers on vessels sailing under a German flag.

Science.gov (United States)

Oldenburg, Marcus; Jensen, Hans-Joachim; Latza, Ute; Baur, Xaver

2010-01-01

This study aimed to predict the risk of coronary heart disease (CHD) among seafarers on German-flagged vessels and to assess the association of shipboard job duration at sea with the risk of CHD. During the legally required medical fitness test for nautical service, 161 seafarers in Hamburg participated in a cross-sectional study which included an interview, blood sampling, and blood pressure measurements (response 84.9%). The predicted 10-year risk of an acute coronary event of the examined German seafarers aged 35 to 64 years (n = 46) was assessed in comparison with a sample of male German employees of the same age working ashore (PROCAM study). The number of independent CHD risk factors (according to the PROCAM study) was compared in the groups with 'shorter' and 'longer' median shipboard job duration at sea (15.0 years). The examined German seafarers had a similar age-standardized predicted 10-year CHD risk as the German reference population. Nearly all independent CHD risk factors were significantly more frequent in seamen with job duration at sea of ≥ 15 years than in those with 〈 15 years. After adjusting for age, the number of CHD risk factors was associated with job duration (OR 1.08 [95% CI 1.02-1.14] per year). Seafarers on German-flagged ships have to attend a medical fitness test for nautical service every 2 years. Thus, it can be assumed that seafarers present a healthier population than employees ashore. In this study, however, CHD risk of seafarers was similar to that of the reference population. This may indicate that working onboard implies a high coronary risk. Furthermore, the study results suggest a tendency of increased risk of CHD among seafarers with longer job duration at sea.

Radiological criteria for underground nuclear tests

International Nuclear Information System (INIS)

Malik, J.S.; Brownlee, R.R.; Costa, C.F.; Mueller, H.F.; Newman, R.W.

1981-04-01

The radiological criteria for the conduct of nuclear tests have undergone many revisions with the current criteria being 0.17 rad for uncontrolled populations and 0.5 rad for controllable populations. Their effect upon operations at the Nevada Test Site and the current off-site protective plans are reviewed for areas surrounding the Site. The few accidental releases that have occurred are used to establish estimates of probability of release and of hazard to the population. These are then put into context by comparing statistical data on other accidents and cataclysms. The guidelines established by DOE Manual Chapter MC-0524 have never been exceeded during the entire underground nuclear test program. The probability of real hazard to off-site populations appears to be sufficiently low as not to cause undue concern to the citizenry

Radiological criteria for underground nuclear tests

Energy Technology Data Exchange (ETDEWEB)

Malik, J.S.; Brownlee, R.R.; Costa, C.F.; Mueller, H.F.; Newman, R.W.

1981-04-01

The radiological criteria for the conduct of nuclear tests have undergone many revisions with the current criteria being 0.17 rad for uncontrolled populations and 0.5 rad for controllable populations. Their effect upon operations at the Nevada Test Site and the current off-site protective plans are reviewed for areas surrounding the Site. The few accidental releases that have occurred are used to establish estimates of probability of release and of hazard to the population. These are then put into context by comparing statistical data on other accidents and cataclysms. The guidelines established by DOE Manual Chapter MC-0524 have never been exceeded during the entire underground nuclear test program. The probability of real hazard to off-site populations appears to be sufficiently low as not to cause undue concern to the citizenry.

[Photosynthetic gas exchange and water utilization of flag leaf of spring wheat with bunch sowing and field plastic mulching below soil on semi-arid rain-fed area.

Science.gov (United States)

Yang, Wen Xiong; Liu, Na; Liu, Xiao Hua; Zhang, Xue Ting; Wang, Shi Hong; Yuan, Jun Xiu; Zhang, Xu Cheng

2016-07-01

Based on the field experiment which was conducted in Dingxi County of Gansu Province, and involved in the three treatments: (1) plastic mulching on entire land with soil coverage and bunching (PMS), (2) plastic mulching on entire land and bunching (PM), and (3) direct bunching without mulching (CK). The parameters of SPAD values, chlorophyll fluorescence parameters, photosynthetic gas exchange parameters, as well as leaf area index (LAI), yield, evapotranspiration, and water use efficiency in flag leaves of spring wheat were recorded and analyzed from 2012 to 2013 continuously. The results showed that SPAD values of wheat flag leaves increased in PMS by 10.0%-21.5% and 3.2%-21.6% compared to PM and CK in post-flowering stage, respectively. The maximum photochemical efficiency (F v /F m ) , actual photochemical efficiency (Φ PS 2 ) of photosystem 2 (PS2), and photochemical quenching coefficient (q P ) of PMS were higher than those of PM and CK, the maximum increment values were 6.1%, 9.6% and 30.9% as compared with PM, and significant differences were observed in filling stage (P＜0.05). The values of q N in PMS were lowest among the three treatments, and it decreased significantly by 23.8% and 15.4% in heading stage in 2012 and 2013 respectively, as compared with PM. The stoma conductance (g s ) of wheat flag leaves in PMS was higher than that of PM and CK, with significant difference being observed in filling stage, and it increased by 17.1% and 21.1% in 2012 and 2013 respectively, as compared with PM. The transpiration rate (T r ), net photosynthetic rate (P n ), and leaf instantaneous water use efficiency (WUE i ) except heading stage in 2013 of PMS increased by 5.4%-16.7%, 11.2%-23.7%, and 5.6%-7.2%, respectively, as compared with PM, and significant difference of WUE i was observed in flowering stage in 2012. The leaf area index (LAI) of PMS was higher than that of PM and CK, especially, it differed significantly in seasonal drought of 2013. Consequently

Developing 2 C-compatible investment criteria

Energy Technology Data Exchange (ETDEWEB)

Roeser, Frauke [NewClimate - Institute for Climate Policy and Global Sustainability gGmbH, Bonn (Germany); Weischer, Lutz [Germanwatch e.V., Koeln (Germany); Thomae, Jakob [2degrees Investing Initiative, New York, NY (United States); Hoehne, Niklas; Hagemann, Markus; El Alaoui, Alexander; Bals, Christoph; Eckstein, David; Kreft, Soenke; Rosse, Morten

2015-11-30

This report studies the development of criteria for assessing the compatibility of financial investments with the international goal to limit global temperature increase to below 2 C above pre-industrial levels. The findings are intended as a starting point and a key input for a longer term process to develop consensus-based 2 C investing criteria. The focus here is placed on investments in projects and physical assets, in particular of development and climate finance organisations. In order to limit global temperature increase to 2 C, global greenhouse gas (GHG) emissions will have to be reduced significantly, eventually to zero, during the course of this century. This requires shifting capital from high to low carbon investments as well as significant capital mobilisation for investments in 2 C-compatible infrastructure. Given the long lifetime of physical assets, and the urgency of decarbonisation over the coming decades, this needs to begin today. Public financial institutions can play a prominent role in contributing to aligning investment flows with the 2 C limit, as well as in closing the current infrastructure investment gap, responding to their explicit or implicit climate mandates and leadership role in the finance sector. The majority of international financial institutions integrate climate considerations into their finance decisions to some degree, and are familiar with different types of criteria, including positive and negative lists, qualitative and quantitative benchmarks, and the use of shadow carbon pricing. However, current approaches do not link to the 2 C limit. 2 C investment criteria are therefore needed to guide investors in this regard. Such criteria may also support other purposes, including an understanding of climate risks and improved reporting and accountability.

Developing 2 C-compatible investment criteria

International Nuclear Information System (INIS)

Roeser, Frauke; Weischer, Lutz; Thomae, Jakob; Hoehne, Niklas; Hagemann, Markus; El Alaoui, Alexander; Bals, Christoph; Eckstein, David; Kreft, Soenke; Rosse, Morten

2015-01-01

This report studies the development of criteria for assessing the compatibility of financial investments with the international goal to limit global temperature increase to below 2 C above pre-industrial levels. The findings are intended as a starting point and a key input for a longer term process to develop consensus-based 2 C investing criteria. The focus here is placed on investments in projects and physical assets, in particular of development and climate finance organisations. In order to limit global temperature increase to 2 C, global greenhouse gas (GHG) emissions will have to be reduced significantly, eventually to zero, during the course of this century. This requires shifting capital from high to low carbon investments as well as significant capital mobilisation for investments in 2 C-compatible infrastructure. Given the long lifetime of physical assets, and the urgency of decarbonisation over the coming decades, this needs to begin today. Public financial institutions can play a prominent role in contributing to aligning investment flows with the 2 C limit, as well as in closing the current infrastructure investment gap, responding to their explicit or implicit climate mandates and leadership role in the finance sector. The majority of international financial institutions integrate climate considerations into their finance decisions to some degree, and are familiar with different types of criteria, including positive and negative lists, qualitative and quantitative benchmarks, and the use of shadow carbon pricing. However, current approaches do not link to the 2 C limit. 2 C investment criteria are therefore needed to guide investors in this regard. Such criteria may also support other purposes, including an understanding of climate risks and improved reporting and accountability.

15 CFR 970.801 - Criteria for safety of life and property at sea.

Science.gov (United States)

2010-01-01

... REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES Safety... jurisdiction on the high seas and subject to domestic enforcement procedures. With respect to foreign flag...

Plugging criteria for WWER SG tubes

Energy Technology Data Exchange (ETDEWEB)

Papp, L.; Wilam, M. [Vitkovice NPP Services (Switzerland); Herman, M. [Vuje, Trnava (Slovakia)

1997-12-31

At operated Czech and Slovak nuclear power plants the 80 % criteria for crack or other bulk defect depth is used for steam generator heat exchanging tubes plugging. This criteria was accepted as the recommendation of designer of WWER steam generators. Verification of this criteria was the objective of experimental program performed by Vitkovice, J.S.C., UJV Rez, J.S.C. and Vuje Trnava, J.S.C .. Within this program the following factors were studied: (1) Influence of secondary water chemistry on defects initiation and propagation, (2) Statistical evaluation of corrosion defects progression at operated SG, and (3) Determination of critical pressure for tube rupture as a function of eddy current indications. In this presentation items (2) and (3) are considered.

Plugging criteria for WWER SG tubes

Energy Technology Data Exchange (ETDEWEB)

Papp, L; Wilam, M [Vitkovice NPP Services (Switzerland); Herman, M [Vuje, Trnava (Slovakia)

1998-12-31

At operated Czech and Slovak nuclear power plants the 80 % criteria for crack or other bulk defect depth is used for steam generator heat exchanging tubes plugging. This criteria was accepted as the recommendation of designer of WWER steam generators. Verification of this criteria was the objective of experimental program performed by Vitkovice, J.S.C., UJV Rez, J.S.C. and Vuje Trnava, J.S.C .. Within this program the following factors were studied: (1) Influence of secondary water chemistry on defects initiation and propagation, (2) Statistical evaluation of corrosion defects progression at operated SG, and (3) Determination of critical pressure for tube rupture as a function of eddy current indications. In this presentation items (2) and (3) are considered.

Nuclear Fuel Safety Criteria Technical Review - Second edition

International Nuclear Information System (INIS)

Beck, Winfried; Blanpain, Patrick; Fuketa, Toyoshi; Gorzel, Andreas; Hozer, Zoltan; Kamimura, Katsuichiro; Koo, Yang-Hyun; Maertens, Dietmar; Nechaeva, Olga; Petit, Marc; Rehacek, Radomir; Rey-Gayo, Jose Maria; Sairanen, Risto; Sonnenburg, Heinz-Guenther; Valach, Mojmir; Waeckel, Nicolas; Yueh, Ken; Zhang, Jinzhao; Voglewede, John

2012-01-01

Most of the current nuclear fuel safety criteria were established during the 1960's and early 1970's. Although these criteria were validated against experiments with fuel designs available at that time, a number of tests were based on unirradiated fuels. Additional verification was performed as these designs evolved, but mostly with the aim of showing that the new designs adequately complied with existing criteria, and not to establish new limits. In 1996, the OECD Nuclear Energy Agency (NEA) reviewed existing fuel safety criteria, focusing on new fuel and core designs, new cladding materials and industry manufacturing processes. The results were published in the Nuclear Fuel Safety Criteria Technical Review of 2001. The NEA has since re-examined the criteria. A brief description of each criterion and its rationale are presented in this second edition, which will be of interest to both regulators and industry (fuel vendors, utilities)

15 CFR 971.701 - Criteria for safety of life and property at sea.

Science.gov (United States)

2010-01-01

... REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR COMMERCIAL RECOVERY PERMITS... (pursuant to § 971.205(a)). United States flag vessels are under United States jurisdiction on the high seas...

DOE Standard: Fire protection design criteria

International Nuclear Information System (INIS)

1999-07-01

The development of this Standard reflects the fact that national consensus standards and other design criteria do not comprehensively or, in some cases, adequately address fire protection issues at DOE facilities. This Standard provides supplemental fire protection guidance applicable to the design and construction of DOE facilities and site features (such as water distribution systems) that are also provided for fire protection. It is intended to be used in conjunction with the applicable building code, National Fire Protection Association (NFPA) Codes and Standards, and any other applicable DOE construction criteria. This Standard replaces certain mandatory fire protection requirements that were formerly in DOE 5480.7A, ''Fire Protection'', and DOE 6430.1A, ''General Design Criteria''. It also contains the fire protection guidelines from two (now canceled) draft standards: ''Glove Box Fire Protection'' and ''Filter Plenum Fire Protection''. (Note: This Standard does not supersede the requirements of DOE 5480.7A and DOE 6430.1A where these DOE Orders are currently applicable under existing contracts.) This Standard, along with the criteria delineated in Section 3, constitutes the basic criteria for satisfying DOE fire and life safety objectives for the design and construction or renovation of DOE facilities

The colors of the Brazilian flag in different lighting scenarios

Directory of Open Access Journals (Sweden)

Lenizia Ferreira Silva

2017-08-01

Full Text Available Aiming to clarify concepts related to Optics and its teaching methodologies, above all on the perception of objects when illuminated with light sources in certain colors or bands of the light spectrum, an analysis was developed focusing on the problem of visual perception of Brazilian flag colors, considering different lighting scenarios. This question, usually applied in the teachers' daily routine, has presented conflicting answers in some relevant tools in the teaching-learning of Physics. The tools, in which were obtained  such results, contemplate didactic books of the discipline of Physics of High School; One of the selection tests of the Mestrado Nacional Profissional em Ensino de Física – MNPEF (2015, from Sociedade Brasileira de Física – SBF; As well as, digital simulations conceived in the software Cores - Óptica, belonging to the project Acessa Física. As a proposal to solve the doubts identified during the comparison of these resources, in the context of the Programa de Educação Tutorial – PET, the experimentation was adopted, through a practice with simple and accessible materials. The results demonstrated the importance of the experiments, as a way of elucidating conflicting concepts, deepening the analysis of the issue discussed and promoting a new perspective for the study of colors.

Computer assisted instruction on "learning nutrition flags for deaf 5th grade and 6th grad students": effectiveness of instruction.

Science.gov (United States)

Srisorachatr, Suwat; Huadong, Yotsinee; Hudthagosol, Chatrapa; Danthanavanich, Suksiri

2013-12-01

Deaf students are of a number of under privilege group for whom there are limited resources for their use, related to health including nutrition. The purpose of this research was to create computer-assisted instruction for "nutrition flags" for 5 and 6th grade students. The content of nutrition included the concept of a healthy balance diets and portion sizes of each food group. The content and pictures for computer-assisted instruction came from existing curriculum, and focused on nutritional content. The contents in this instruction were divided into three units according to students' learning capacity. The story boards were developed by staff including nutritionists, Thai sign language interpreters, and deaf students. Then, the contents and nutrition vocabulary were translated into Thai sign language. After recording the sign language on video, this material was merged with the contents and converted into a computer program. The computer assisted instruction was tested with students from Nakon Pathom School for the Deaf The first trial was conducted with three students, the second with five students, and the third with 15 students during the academic year 2009. The computer- assisted instruction was revised until it met the standard criteria of 80/80. Effectiveness testing was carried out with 36 students for five consecutive days. On the first day, the pre-test was completed, and on days 2-4, the students performed self-study and completed the exercises for units 1-3, with 50 minutes spent on each unit. The post-test was completed on the last day. The study was conducted during the 2010 academic year Data analysis was performed using the t-test. The results showed an effectiveness of 81.85/82.22, which was higher than the standard criteria of 80/80. The post-test average score was higher than the pre-test average score with a statistical significance level at p < 0.0001. Suggestions for instruction for the deaf are that the length of the instruction in each

Maintenance evaluation using risk based criteria

International Nuclear Information System (INIS)

Torres Valle, A.

1996-01-01

The maintenance evaluation is currently performed by using economic and, in some case, technical equipment failure criteria, however this is done to a specific equipment level. In general, when statistics are used the analysis for maintenance optimization are made isolated and whit a post mortem character; The integration provided by mean of Probabilistic Safety assessment (PSA) together with the possibilities of its applications, allow for evaluation of maintenance on the basis of broader scope criteria in regard to those traditionally used. The evaluate maintenance using risk based criteria, is necessary to follow a dynamic and systematic approach, in studying the maintenance strategy, to allow for updating the initial probabilistic models, for including operational changes that often take place during operation of complex facilities. This paper proposes a dynamic evaluation system of maintenance task. The system is illustrated by means of a practical example

(U) Physics Validation of the RMI-Based Ejecta Source Model Implementation in FLAG: L2 Milestone #6035 Report

Energy Technology Data Exchange (ETDEWEB)

Tregillis, I. L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-09-14

The Los Alamos Physics and Engineering Models (PEM) program has developed a model for Richtmyer-Meshkov instability (RMI) based ejecta production from shock-melted surfaces, along with a prescription for a self-similar velocity distribution (SSVD) of the resulting ejecta particles. We have undertaken an effort to validate this source model using data from explosively driven tin coupon experiments. The model’s current formulation lacks a crucial piece of physics: a method for determining the duration of the ejecta production interval. Without a mechanism for terminating ejecta production, the model is not predictive. Furthermore, when the production interval is hand-tuned to match time-integrated mass data, the predicted time-dependent mass accumulation on a downstream sensor rises too sharply at early times and too slowly at late times because the SSVD overestimates the amount of mass stored in the fastest particles and underestimates the mass stored in the slowest particles. The functional form of the resulting m(t) is inconsistent with the available time-dependent data; numerical simulations and analytic studies agree on this point. Simulated mass tallies are highly sensitive to radial expansion of the ejecta cloud. It is not clear if the same effect is present in the experimental data but if so, depending on the degree, this may challenge the model’s compatibility with tin coupon data. The current implementation of the model in FLAG is sensitive to the detailed interaction between kinematics (hydrodynamic methods) and thermodynamics (material models); this sensitivity prohibits certain physics modeling choices. The appendices contain an extensive analytic study of piezoelectric ejecta mass measurements, along with test problems, excerpted from a longer work (LA-UR-17-21218).

A demonstration of NIOSH push-pull ventilation criteria.

Science.gov (United States)

Klein, M K

1987-03-01

This paper summarizes the results of a study performed on an actual chrome plating tank in order to validate criteria for push-pull ventilation systems developed by Huebener and Hughes at NIOSH. Validation of the criteria was made by taking area industrial hygiene samples for hexavalent and total chrome at ten locations around the plating tank. The sampling was performed during actual production runs or while the tank was operating with a dummy load. The sampling data are summarized. The data show that the push-pull system, operating at Huebener's criteria, could control emissions to below the current standards and guidelines. Conclusions and recommendations are included.

Bioactivity of Sweet Flag (Acorus calamus Linnaeus Essential Oils against Spodoptera litura Fabricius (Lepidoptera: Noctuidae

Directory of Open Access Journals (Sweden)

Dewi Melani

2016-05-01

The study aims to determine the chemical compounds, toxicity, and antifeedant activity of sweet flag (Acorus calamus essential oils against third instar larvae of Spodoptera litura. The study was conducted using a completely randomized design (CRD using various concentration of the essential oils (103, 2 × 103, 3 × 103, 4 × 103, 5 × 103 ppm. Mortality and antifeedant activity was observed 24 hours after treatment.  Toxicity and antifeedant activity values were 92.5% and 79.3%, respectively, with an LC50 value 586.96 ppm. Gas chromatography-mass spectrometry analysis showed that essential oil of A. calamus consists of five chemical compounds: methyl isoeugenol, 3.9-decadien-ol-1,3-methyl-6-(1-methylethenyl, 4-pentyl-1-(4propylcyclohexyl1cyclohexene, γ-asarone and β asarone.

Current and future priorities for mass and material in silicon PV module recycling

Energy Technology Data Exchange (ETDEWEB)

Olson, C.L.; Geerligs, L.J.; Goris, M.J.A.A.; Bennett, I.J. [ECN Solar Energy, P.O. Box 1, 1755 ZG Petten (Netherlands); Clyncke, J. [PV CYCLE, Rue Montoyer 23, 1000 Brussels (Belgium)

2013-10-15

A full description of the state-of-the-art PV recycling methods and their rationale is presented, which discusses the quality of the recycled materials and the fate of the substances which end up in the landfill. The aim is to flag the PV module components currently not recycled, which may have a priority in terms of their embedded energy, chemical nature or scarcity, for the next evolution of recycling. The sustainability of different recycling options, emerging in the literature on electronic waste recycling, and the possible improvement of the environmental footprint of silicon PV modules, will be discussed.

Phenomenology of Schizophrenia and the Representativeness of Modern Diagnostic Criteria.

Science.gov (United States)

Kendler, Kenneth S

2016-10-01

symptoms/signs and current diagnostic systems highlights the limitations of clinical evaluations and research studies that restrict the diagnostic assessments to current diagnostic criteria. We should not confuse our DSM diagnostic criteria with the disorders that they were designed to index.

DSM disorders and their criteria: how should they inter-relate?

Science.gov (United States)

Kendler, K S

2017-09-01

conceptual error. It assumes a definitiveness and a literalism about the nature of our criteria that is far beyond our current knowledge. The indexical position with its tentativeness and modesty accurately reflects the current state of our field.

A Comparison of the Green Building’s Criteria

Directory of Open Access Journals (Sweden)

Bahaudin A.Y.

2014-01-01

Full Text Available Designers and clients alike are now emphasising on how to make their buildings green. Currently a lot of green councils worldwide are dealing with innovative ways to implement energy efficient new buildings. They have adopted various criteria and rating systems in an endeavour to classify buildings that contribute to environment sustainability, efficiency and users health. The aim of the paper is to present an overview of the criteria adopted by selected green building councils. This paper discusses five of the rating systems available in terms of their similarities and differences and proposes a new framework based on the project life cycle for the development of the green building criteria. Criteria during the construction phase of the building is certainly lacking such as pollution control in terms of CO2 emission, dust, and other pollutants.

The Criteria for Determining the Business Failure

Directory of Open Access Journals (Sweden)

Luminiţa TULEAŞCĂ

2012-03-01

Full Text Available The business failure represents a current problem in any economic and social context and, for this reason, the legislator has been concerned with the regulation of the criteria based on which to accurately determine the failure of a business man when the case. The liquidity test and the balance sheet test, or the insolvency and insolvability are the criteria for determining the business failure usually materialized by undergoing the bankruptcy procedure. The legislator’s option for one or another of these criteria represents a structural option depending on the legal culture of each state however, considering the economic causes and effects of the insolvability and insolvency, that tends to remove the unilateral, exclusivist options. This paper illustrates significant option differences between the criteria for determining the business failure in the member states of the European Union which is the most used criterion and, if these criteria can be equally used in the banking and insurance sector. Last but not least, the paper illustrates the meanings of insolvency and insolvability in different matters and different laws and the need to eliminate the reserve that the Romanian doctrine manifests towards the insolvability concept as a cause for bankruptcy.

Multi-Criteria Approach in Multifunctional Building Design Process

Science.gov (United States)

Gerigk, Mateusz

2017-10-01

The paper presents new approach in multifunctional building design process. Publication defines problems related to the design of complex multifunctional buildings. Currently, contemporary urban areas are characterized by very intensive use of space. Today, buildings are being built bigger and contain more diverse functions to meet the needs of a large number of users in one capacity. The trends show the need for recognition of design objects in an organized structure, which must meet current design criteria. The design process in terms of the complex system is a theoretical model, which is the basis for optimization solutions for the entire life cycle of the building. From the concept phase through exploitation phase to disposal phase multipurpose spaces should guarantee aesthetics, functionality, system efficiency, system safety and environmental protection in the best possible way. The result of the analysis of the design process is presented as a theoretical model of the multifunctional structure. Recognition of multi-criteria model in the form of Cartesian product allows to create a holistic representation of the designed building in the form of a graph model. The proposed network is the theoretical base that can be used in the design process of complex engineering systems. The systematic multi-criteria approach makes possible to maintain control over the entire design process and to provide the best possible performance. With respect to current design requirements, there are no established design rules for multifunctional buildings in relation to their operating phase. Enrichment of the basic criteria with functional flexibility criterion makes it possible to extend the exploitation phase which brings advantages on many levels.

Country report Denmark

DEFF Research Database (Denmark)

Mogensen, Finn; Breiting, Søren

2005-01-01

Quality criteria for the work of Danish schools working with environmental education or education for sustainable development as they can be revealed in documents related to special initiatives like green flag - green school projects and ecoschools. These are described as part of the state...... of environmental education and education for sustainable development in Denmark, and include explicit criteria as well as implicit criteria....

Air Quality Criteria for Particulate Matter.

Science.gov (United States)

National Air Pollution Control Administration (DHEW), Washington, DC.

To assist states in developing air quality standards, this book offers a review of literature related to atmospheric particulates and the development of criteria for air quality. It not only summarizes the current scientific knowledge of particulate air pollution, but points up the major deficiencies in that knowledge and the need for further…

Copy Number Variation of Cytokinin Oxidase Gene Tackx4 Associated with Grain Weight and Chlorophyll Content of Flag Leaf in Common Wheat.

Science.gov (United States)

Chang, Cheng; Lu, Jie; Zhang, Hai-Ping; Ma, Chuan-Xi; Sun, Genlou

2015-01-01

As the main pigment in photosynthesis, chlorophyll significantly affects grain filling and grain weight of crop. Cytokinin (CTK) can effectively increase chlorophyll content and chloroplast stability, but it is irreversibly inactivated by cytokinin oxidase (CKX). In this study, therefore, twenty-four pairs of primers were designed to identify variations of wheat CKX (Tackx) genes associated with flag leaf chlorophyll content after anthesis, as well as grain weight in 169 recombinant inbred lines (RIL) derived from Triticum aestivum Jing 411 × Hongmangchun 21. Results indicated variation of Tackx4, identified by primer pair T19-20, was proven to significantly associate with chlorophyll content and grain weight in the RIL population. Here, two Tackx4 patterns were identified: one with two co-segregated fragments (Tackx4-1/Tackx4-2) containing 618 bp and 620 bp in size (as in Jing 411), and another with no PCR product. The two genotypes were designated as genotype-A and genotype-B, respectively. Grain weight and leaf chlorophyll content at 5~15 days after anthesis (DAA) were significantly higher in genotype-A lines than those in genotype-B lines. Mapping analysis indicated Tackx4 was closely linked to Xwmc169 on chromosome 3AL, as well as co-segregated with a major quantitative trait locus (QTL) for both grain weight and chlorophyll content of flag leaf at 5~15 DAA. This QTL explained 8.9~22.3% phenotypic variations of the two traits across four cropping seasons. Among 102 wheat varieties, a third genotype of Tackx4 was found and designated as genotype-C, also having two co-segregated fragments, Tackx4-2 and Tackx4-3 (615bp). The sequences of three fragments, Tackx4-1, Tackx4-2, and Tackx4-3, showed high identity (>98%). Therefore, these fragments could be considered as different copies at Tackx4 locus on chromosome 3AL. The effect of copy number variation (CNV) of Tackx4 was further validated. In general, genotype-A contains both significantly higher grain weight

Diagnosing antiphospholipid syndrome: 'extra-criteria' manifestations and technical advances.

Science.gov (United States)

Sciascia, Savino; Amigo, Mary-Carmen; Roccatello, Dario; Khamashta, Munther

2017-09-01

First described in the early 1980s, antiphospholipid syndrome (APS) is a unique form of acquired autoimmune thrombophilia in which patients present with clinical features of recurrent thrombosis and pregnancy morbidity and persistently test positive for the presence of antiphospholipid antibodies (aPL). At least one clinical (vascular thrombosis or pregnancy morbidity) and one lab-based (positive test result for lupus anticoagulant, anticardiolipin antibodies and/or anti-β2-glycoprotein 1 antibodies) criterion have to be met for a patient to be classified as having APS. However, the clinical spectrum of APS encompasses additional manifestations that can affect many organs and cannot be explained exclusively by patients being in a prothrombotic state; clinical manifestations not listed in the classification criteria (known as extra-criteria manifestations) include neurologic manifestations (chorea, myelitis and migraine), haematologic manifestations (thrombocytopenia and haemolytic anaemia), livedo reticularis, nephropathy and valvular heart disease. Increasingly, research interest has focused on the development of novel assays that might be more specific for APS than the current aPL tests. This Review focuses on the current classification criteria for APS, presenting the role of extra-criteria manifestations and lab-based tests. Diagnostic approaches to difficult cases, including so-called seronegative APS, are also discussed.

The DSM Diagnostic Criteria for Gender Identity Disorder in Adolescents and Adults

OpenAIRE

Cohen-Kettenis, P.T.; Pfafflin, F.

2010-01-01

Apart from some general issues related to the Gender Identity Disorder (GID) diagnosis, such as whether it should stay in the DSM-V or not, a number of problems specifically relate to the current criteria of the GID diagnosis for adolescents and adults. These problems concern the confusion caused by similarities and differences of the terms transsexualism and GID, the inability of the current criteria to capture the whole spectrum of gender variance phenomena, the potential risk of unnecessar...

Fuel safety criteria and review by OECD / CSNI task force

International Nuclear Information System (INIS)

Van Doesburg, W.

1999-01-01

Full text of publication follows: with the advent of advanced fuel and core designs, and the implementation of more accurate (best estimate or statistical) design and analysis methods, there is a general feeling that safety margins have been or are being reduced. Historically, fuel safety margins were defined by adding conservatism to the safety limits, which in turn were also fixed in a conservative manner, here, the expression 'conservatism' expresses the fact that bounding or limiting numbers were chosen for model parameters, plant and fuel design data, and fuel operating history values. Unfortunately, as these conservatisms were not quantified (or quantifiable), the amount of safety available or the reduction thereof is difficult to substantiate. For the regulator, it is important to know the margin available with the utilities' request for approval of new fuel or methods; likewise, for the utility and vendor it is important to know what margins exist and what they are based on, to identify in which direction they can make further progress and optimize fuel and fuel cycle cost. Naturally, each party involved will have to decide on how much margin should be in place, to establish operational criteria and ensure that these can actually be met during operation. To assess the margins issue, safety criteria themselves need to be reviewed first. Most - if not all - of the currently existing safety criteria were established during the 60's and early 70's, and verified against experiments with fuel available at that time - mostly at zero exposure. Of course, verification was performed as designs progressed in later years, primarily with the aim to be able to prove that safety criteria were adequate as long as the said conservatisms would be retained, and not with the aim to reestablish limits. The mandate to the OECD/CSNI/PWG2 Task Force on Fuel Safety Criteria (TFFSC) is to assess the adequacy of existing fuel safety criteria, in view of the 'new design' elements (new

Phenotyping of field-grown wheat in the UK highlights contribution of light response of photosynthesis and flag leaf longevity to grain yield.

Science.gov (United States)

Carmo-Silva, Elizabete; Andralojc, P John; Scales, Joanna C; Driever, Steven M; Mead, Andrew; Lawson, Tracy; Raines, Christine A; Parry, Martin A J

2017-06-15

Improving photosynthesis is a major target for increasing crop yields and ensuring food security. Phenotyping of photosynthesis in the field is critical to understand the limits to crop performance in agricultural settings. Yet, detailed phenotyping of photosynthetic traits is relatively scarce in field-grown wheat, with previous studies focusing on narrow germplasm selections. Flag leaf photosynthetic traits, crop development, and yield traits were compared in 64 field-grown wheat cultivars in the UK. Pre-anthesis and post-anthesis photosynthetic traits correlated significantly and positively with grain yield and harvest index (HI). These traits included net CO2 assimilation measured at ambient CO2 concentrations and a range of photosynthetic photon flux densities, and traits associated with the light response of photosynthesis. In most cultivars, photosynthesis decreased post-anthesis compared with pre-anthesis, and this was associated with decreased Rubisco activity and abundance. Heritability of photosynthetic traits suggests that phenotypic variation can be used to inform breeding programmes. Specific cultivars were identified with traits relevant to breeding for increased crop yields in the UK: pre-anthesis photosynthesis, post-anthesis photosynthesis, light response of photosynthesis, and Rubisco amounts. The results indicate that flag leaf longevity and operating photosynthetic activity in the canopy can be further exploited to maximize grain filling in UK bread wheat. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Flagging and correcting non-spectral matrix interferences with spatial emission profiles and gradient dilution in inductively coupled plasma-atomic emission spectrometry

International Nuclear Information System (INIS)

Cheung, Yan; Schwartz, Andrew J.; Chan, George C.-Y.; Hieftje, Gary M.

2015-01-01

Matrix interference remains one of the most daunting challenges commonly encountered in inductively coupled plasma-atomic emission spectrometry (ICP-AES). In the present study, a method is described that enables identification and correction of matrix interferences in axial-viewed ICP-AES through a combination of spatial mapping and on-line gradient dilution. Cross-sectional emission maps of the plasma are used to indicate the presence of non-spectral (plasma-related and sample-introduction-related) matrix interferences. In particular, apparent concentrations of an analyte species determined at various radial locations in the plasma differ in the presence of a matrix interference, which allows the interference to be flagged. To correct for the interference, progressive, on-line dilution of the sample, performed by a gradient high-performance liquid-chromatograph pump, is utilized. The spatially dependent intensities of analyte emission are monitored at different levels of sample dilution. As the dilution proceeds, the matrix-induced signal variation is reduced. At a dilution where the determined concentrations become independent of location in the plasma, the matrix interference is minimized. - Highlights: • Non-spectral matrix interference in ICP-AES is flagged and minimized. • Emission from different locations of the plasma are collected simultaneously. • Spatially dependent determined concentrations indicate the presence of interference. • Gradient dilution is performed on both calibration standards and sample. • Optimal dilution factor to minimize interference is found as dilution increases

Flagging and correcting non-spectral matrix interferences with spatial emission profiles and gradient dilution in inductively coupled plasma-atomic emission spectrometry

Energy Technology Data Exchange (ETDEWEB)

Cheung, Yan; Schwartz, Andrew J.; Chan, George C.-Y.; Hieftje, Gary M., E-mail: hieftje@indiana.edu

2015-08-01

Matrix interference remains one of the most daunting challenges commonly encountered in inductively coupled plasma-atomic emission spectrometry (ICP-AES). In the present study, a method is described that enables identification and correction of matrix interferences in axial-viewed ICP-AES through a combination of spatial mapping and on-line gradient dilution. Cross-sectional emission maps of the plasma are used to indicate the presence of non-spectral (plasma-related and sample-introduction-related) matrix interferences. In particular, apparent concentrations of an analyte species determined at various radial locations in the plasma differ in the presence of a matrix interference, which allows the interference to be flagged. To correct for the interference, progressive, on-line dilution of the sample, performed by a gradient high-performance liquid-chromatograph pump, is utilized. The spatially dependent intensities of analyte emission are monitored at different levels of sample dilution. As the dilution proceeds, the matrix-induced signal variation is reduced. At a dilution where the determined concentrations become independent of location in the plasma, the matrix interference is minimized. - Highlights: • Non-spectral matrix interference in ICP-AES is flagged and minimized. • Emission from different locations of the plasma are collected simultaneously. • Spatially dependent determined concentrations indicate the presence of interference. • Gradient dilution is performed on both calibration standards and sample. • Optimal dilution factor to minimize interference is found as dilution increases.

When Less Is More: How Fewer Diagnostic Criteria Can Indicate Greater Severity

Science.gov (United States)

Cooper, Luke D.; Balsis, Steve

2009-01-01

For diagnosing many mental disorders, the current "Diagnostic and Statistical Manual of Mental Disorders" ("DSM") system weights each diagnostic criterion equally--each criterion counts the same toward meeting the diagnostic threshold. Research on the diagnostic efficiency of criteria, however, reveals that some diagnostic criteria are more useful…

21 CFR 114.5 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 114.5 Section...) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS General Provisions § 114.5 Current good manufacturing practice. The criteria in §§ 114.10, 114.80, 114.83, 114.89, and 114.100, as well as the criteria in part...

HWVP compliance with the Hanford site solid waste acceptance criteria

International Nuclear Information System (INIS)

Bromm, R.; Ornelas, J.; Fundingsland, S.; Shah, K.

1993-01-01

In order to ensure that the Hanford Waste Vitrification Project (HWVP) will meet solid waste acceptance criteria, a review of the criteria was performed. The primary purpose of the study was to evaluate the modifications that will be required to bring the HWVP into compliance for secondary waste which will be generated during normal operations of the facility. To accomplish this objective, the current HWVP design was evaluated based on the criteria established. Once the non-compliance areas and potentially non-compliance areas were identified, alternative plant design modifications were proposed. This paper summarizes the results and recommendations of that study

Risk Acceptance Criteria and/or Decision optimization

DEFF Research Database (Denmark)

Ditlevsen, Ove Dalager

1996-01-01

Acceptance criteria applied in practical risk analysis are recapitulated including the concept of rist profile. Modelling of risk profiles is illustrated on the basis of compound Poisson process models. The current practice of authoritative acceptance criteria formulation is discussed from...... a decision theoretical point of view. It is argued that the phenomenon of risk aversion rather than being of concern to the authority should be of concern to the owner. Finally it is discussed whether there is an ethical problem when formally capitalising human lives with a positive interest rate. Keywords......: Risk acceptance, Risk profile, Compound Poisson model for risk profile, Capitalization of human life, Risk aversion....

Radiological protection criteria risk assessments for waste disposal options

International Nuclear Information System (INIS)

Hill, M.D.

1982-01-01

Radiological protection criteria for waste disposal options are currently being developed at the National Radiological Protection Board (NRPB), and, in parallel, methodologies to be used in assessing the radiological impact of these options are being evolved. The criteria and methodologies under development are intended to apply to all solid radioactive wastes, including the high-level waste arising from reprocessing of spent nuclear fuel (because this waste will be solidified prior to disposal) and gaseous or liquid wastes which have been converted to solid form. It is envisaged that the same criteria will be applied to all solid waste disposal options, including shallow land burial, emplacement on the ocean bed (sea dumping), geological disposal on land and sub-seabed disposal

Review of constitutive models and failure criteria for concrete

Energy Technology Data Exchange (ETDEWEB)

Seo, Jeong Moon; Choun, Young Sun [Korea Atomic Energy Research Institute, Taejeon (Korea)

2000-03-01

The general behavior, constitutive models, and failure criteria of concrete are reviewed. The current constitutive models for concrete cannot satisfy all of mechanical behavior of concrete. Among several constitutive models, damage models are recommended to describe properly the structural behavior of concrete containment buildings, because failure modes and post-failure behavior are important in containment buildings. A constitutive model which can describe the concrete behavior in tension is required because the containment buildings will reach failure state due to ultimate internal pressure. Therefore, a thorough study on the behavior and models under tension stress state in concrete and reinforced concrete has to be performed. There are two types of failure criteria in containment buildings: structural failure criteria and leakage failure criteria. For reinforced or prestressed concrete containment buildings, concrete cracking does not mean the structural failure of containment building because the reinforcement or post-tensioning system is able to resist tensile stress up to yield stress. Therefore leakage failure criteria will be prior to structural failure criteria, and a strain failure criterion for concrete has to be established. 120 refs., 59 figs., 1 tabs. (Author)

Effect of combined loading on pipe flaw evaluation criteria

International Nuclear Information System (INIS)

Miura, Naoki; Chung Yeonki

1999-01-01

Considering a rational maintenance rule of Light Water Reactor piping, reliable flaw evaluation criteria are essential to determine how a detected flaw is detrimental to continuous plant operation. Ductile fracture is one of the dominant failure modes to be considered for carbon steel piping, and can be analyzed by the elastic-plastic fracture mechanics. Currently the analytical results are provided as flaw evaluation criteria using load correction factors such like the Z-factor in ASME Code Section 6. The present correction factors were conventionally determined taken a conservatism and a simplicity into account, however, the effect of internal pressure which would be an important factor under an actual plant condition was not adequately considered. Recently, a J-estimation scheme, 'LBB.ENGC' for ductile fracture analysis of circumferentially through-wall-cracked pipes subjected to combined loading was newly developed to have a better prediction with more realistic manner. This method is explicitly incorporated the contribution of both bending and tension due to internal pressure by means of the scheme compatible with an arbitrary combined loading history. In this paper, the effect of internal pressure on the flaw evaluation criteria was investigated using the new J-estimation scheme. A correction factor based on the new J-estimation scheme was compared with the present correction factors, and the predictability of the current flaw evaluation criteria was quantitatively evaluated in consideration of internal pressure. (author)

Helical equilibria and criteria for the kink instability of cylindrical tokamak

International Nuclear Information System (INIS)

Inoue, Sanae; Itoh, Kimitaka; Yoshikawa, Shoichi.

1974-10-01

Helical equilibria and criteria for the kink instability have been obtained numerically for various current distribution, including camel hump distribution. It is found that the unstable region expressed by q(a) is the largest in the case of uniform current. (auth.)

Current quality criteria

International Nuclear Information System (INIS)

Sajaroff, Pedro M.

1999-01-01

The Safety Series 50-C/SG-Q 'Quality Assurance for Safety in Nuclear Power Plants and other Nuclear Installations' published by the IAEA in 1996, contains the Code and 14 Safety Guides. It is more addressed to operating organizations than to regulatory authorities. Priority is assigned to programme implementation and to work effectiveness. Emphasis is putted on doing work correctly from the very beginning (right first time attitude), and not on finding and correcting errors instead of preventing them. The essential aspects for assuring quality (that is, for achieving and maintaining an acceptable level of safety) cover the ten basic requirements established by the Code: Management (QA programme, training and qualification, non-conformance control and corrective actions, document control and records); Performance (work, design, procurement, inspection and testing for acceptance); and Assessment (management self-assessment, independent assessment). These requirements are applicable, on a graded approach basis, to the overall QA programme of the operating organization and its partial programmes during design, construction, commissioning, operation and decommissioning stages. The requirements can be also applied, with due adaptations, to other nuclear installations. The research and development activities related to such stages are comprised under the quality 'umbrella' as well. Therefore the scope of the traditional quality assurance is expanded and consolidated as a management tool more oriented to user. Responsibilities for achieving quality objectives are assigned to all involved individuals and organizations at all levels: management, working groups and assessment teams. Managers' is important but individual responsibilities are unavoidable. For the Argentine Nuclear Regulatory Authority, performance-based quality assurance was not a novelty. In line with the regulatory philosophy (which is essentially based on performance) the regulatory standard AR 3.6.1 (Rev.1) 'Quality System', issued in 1997, is coherent with the Code 50-C-Q. (author)

Accounting for Dark Current Accumulated during Readout of Hubble's ACS/WFC Detectors

Science.gov (United States)

Ryon, Jenna E.; Grogin, Norman A.; Coe, Dan A.; ACS Team

2018-06-01

We investigate the properties of excess dark current accumulated during the 100-second full-frame readout of the Advanced Camera for Surveys (ACS) Wide Field Channel (WFC) detectors. This excess dark current, called "readout dark", gives rise to ambient background gradients and hot columns in each ACS/WFC image. While readout dark signal is removed from science images during the bias correction step in CALACS, the additional noise from the readout dark is currently not taken into account. We develop a method to estimate the readout dark noise properties in ACS/WFC observations. We update the error (ERR) extensions of superbias images to include the appropriate noise from the ambient readout dark gradient and stable hot columns. In recent data, this amounts to about 5 e-/pixel added variance in the rows farthest from the WFC serial registers, and about 7 to 30 e-/pixel added variance along the stable hot columns. We also flag unstable hot columns in the superbias data quality (DQ) extensions. The new reference file pipeline for ACS/WFC implements these updates to our superbias creation process.

Do pneumonia readmissions flagged as potentially preventable by the 3M PPR software have more process of care problems? A cross-sectional observational study.

Science.gov (United States)

Borzecki, Ann M; Chen, Qi; Restuccia, Joseph; Mull, Hillary J; Shwartz, Michael; Gupta, Kalpana; Hanchate, Amresh; Strymish, Judith; Rosen, Amy

2015-12-01

In the USA, administrative data-based readmission rates such as the Centers for Medicare and Medicaid Services' all-cause readmission measures are used for public reporting and hospital payment penalties. To improve this measure and identify better quality improvement targets, 3M developed the Potentially Preventable Readmissions (PPRs) measure. It matches clinically related index admission and readmission diagnoses that may indicate readmissions resulting from admission- or post-discharge-related quality problems. To examine whether PPR software-flagged pneumonia readmissions are associated with poorer quality of care. Using a retrospective observational study design and Veterans Health Administration (VA) data, we identified pneumonia discharges associated with 30-day readmissions, and then flagged cases as PPR-yes or PPR-no using the PPR software. To assess quality of care, we abstracted electronic medical records of 100 random readmissions using a tool containing explicit care processes organised into admission work-up, in-hospital evaluation/treatment, discharge readiness and post-discharge period. We derived quality scores, scaled to a maximum of 25 per section (maximum total score=100) and compared cases by total and section-specific mean scores using t tests and effect size (ES) to characterise the clinical significance of findings. Our abstraction sample was selected from 11,278 pneumonia readmissions (readmission rate=16.5%) during 1 October 2005-30 September 2010; 77% were flagged as PPR-yes. Contrary to expectations, total and section mean quality scores were slightly higher, although non-significantly, among PPR-yes (N=77) versus PPR-no (N=23) cases (respective total scores, 71.2±8.7 vs 65.8±11.5, p=0.14); differences demonstrated ES >0.30 overall and for admission work-up and post-discharge period sections. Among VA pneumonia readmissions, PPR categorisation did not produce the expected quality of care findings. Either PPR-yes cases are not more

Evidence for the diagnostic criteria of delirium: an update.

Science.gov (United States)

Blazer, Dan G; van Nieuwenhuizen, Adrienne O

2012-05-01

Since the publication of DSM-III in 1980, the essential criteria for delirium have been reduced progressively through DSM-III-R to DSM-IV. As the field moves toward DSM-V and ICD-11, new data can shed light on the nosological changes that are needed so that diagnostic criteria can reflect empirical data. In this study, we reassess the existing or potential criteria for delirium. Phenomenological studies in recent years have informed the criteria for delirium, including the appropriateness of the term 'consciousness' as a core symptom of the diagnosis, additional symptoms of delirium that are frequent but are not currently part of the diagnostic criteria, subsyndromal delirium, motoric subtypes of delirium (hyperactive, hypoactive), and the association of delirium with dementia. Recent studies suggest that motoric subtypes should be included as a subtype for delirium but that subsyndromal delirium, although a useful research construct, should not be included in clinical diagnostic criteria given the frequent fluctuation in symptoms over short periods. In addition, though the core symptoms are probably adequate to make the diagnosis, clinicians must be aware of the frequency of other symptoms, for symptoms such as profound sleep disturbance or psychotic symptoms may dominate the clinical picture.

Assessing Psycho-social Barriers to Rehabilitation in Injured Workers with Chronic Musculoskeletal Pain: Development and Item Properties of the Yellow Flag Questionnaire (YFQ).

Science.gov (United States)

Salathé, Cornelia Rolli; Trippolini, Maurizio Alen; Terribilini, Livio Claudio; Oliveri, Michael; Elfering, Achim

2018-06-01

Purpose To develop a multidimensional scale to asses psychosocial beliefs-the Yellow Flag Questionnaire (YFQ)-aimed at guiding interventions for workers with chronic musculoskeletal (MSK) pain. Methods Phase 1 consisted of item selection based on literature search, item development and expert consensus rounds. In phase 2, items were reduced with calculating a quality-score per item, using structure equation modeling and confirmatory factor analysis on data from 666 workers. In phase 3, Cronbach's α, and Pearson correlations coefficients were computed to compare YFQ with disability, anxiety, depression and self-efficacy and the YFQ score based on data from 253 injured workers. Regressions of YFQ total score on disability, anxiety, depression and self-efficacy were calculated. Results After phase 1, the YFQ included 116 items and 15 domains. Further reductions of items in phase 2 by applying the item quality criteria reduced the total to 48 items. Phase factor analysis with structural equation modeling confirmed 32 items in seven domains: activity, work, emotions, harm & blame, diagnosis beliefs, co-morbidity and control. Cronbach α was 0.91 for the total score, between 0.49 and 0.81 for the 7 distinct scores of each domain, respectively. Correlations between YFQ total score ranged with disability, anxiety, depression and self-efficacy was .58, .66, .73, -.51, respectively. After controlling for age and gender the YFQ total score explained between R2 27% and R2 53% variance of disability, anxiety, depression and self-efficacy. Conclusions The YFQ, a multidimensional screening scale is recommended for use to assess psychosocial beliefs of workers with chronic MSK pain. Further evaluation of the measurement properties such as the test-retest reliability, responsiveness and prognostic validity is warranted.

Diagnostic criteria for sarcopenia relate differently to insulin resistance

NARCIS (Netherlands)

Bijlsma, A.Y.; Meskers, C.G.M.; van Heemst, D.; Westendorp, R.G.J.; Craen, A.J.M.; Maier, A.B.

2013-01-01

Skeletal muscle is important in insulinstimulated glucose uptake. Sarcopenia is, therefore, a possible risk factor for insulin resistance. Currently, different diagnostic criteria for sarcopenia include low muscle mass, muscle strength, and walking speed. We assessed these muscle characteristics in

Dual kidney transplantation involving organs from expanded criteria donors: a review of our series and an update on current indications.

Science.gov (United States)

Medina-Polo, J; Pamplona-Casamayor, M; Miranda-Utrera, N; González-Monte, E; Passas-Martínez, J B; Andrés Belmonte, A

2014-12-01

Our purpose was to review our kidney transplantation program based on the use of expanded criteria donors, and to determine current indications for dual kidney transplantation (DKT). In 1996, a program was initiated to transplant kidneys from donors of over 60 years performing single or dual transplantation. In 1996, a program was initiated to transplant kidneys from donors of over 60 years performing single or dual transplantation. DKT were performed with donors >75 and donors between 60 and 74 years of age and glomerulosclerosis of >15%. The kidneys of donors between 60 and 74 years of age and with glomerulosclerosis of 15%, taking into account donor and recipient characteristics. From 1996 to 2004, 222 SKTs and 88 DKTs were performed. Graft survival after 1 and 4 years was, respectively, 91% and 78% for SKT and 95% and 79% for DKT. In 2005, we started to perform SKT despite glomerulosclerosis being >15%, taking into account donor and recipient characteristics. From 2005 to 2011, 328 SKT and 32 DKT were performed. During this period most kidneys used for DKT were from female donors >75 years old, weighing 1 mg/dL and glomerulosclerosis of >15%. The recipients for DKT were mostly male, 75 kg. DKT from expanded criteria donors shows good outcomes. However, in many cases SKT may fulfill the need of the recipient. The archetype for DKT is an older female weighing <65 kg and the most common recipient is an overweight male who is <70 years old. Copyright © 2014 Elsevier Inc. All rights reserved.

Combining the IADPSG criteria with the WHO diagnostic criteria for ...

African Journals Online (AJOL)

Macrosomia or at least one adverse outcome were more likely in GDM patients who met the diagnostic criteria by both the IADPSG and WHO criteria (P = 0.001). Conclusion: A diagnosis of GDM that meets both the WHO and IADPSG criteria provides stronger prediction for adverse pregnancy outcome than a diagnosis that ...

Proposals for new standardized general diagnostic criteria for the secondary headaches

DEFF Research Database (Denmark)

Olesen, J; Steiner, T; Bousser, M-G

2009-01-01

headache and chronic migraine. These changes made apparent a further need for broader revisions to the standard formulation of diagnostic criteria for the secondary headaches. Currently, the fourth criterion makes impossible the definitive diagnosis of a secondary headache until the underlying cause has...... propose maintaining a standard approach to the secondary headaches using a set of four criteria A, B, C and D, but we construct these so that the requirement for resolution or successful treatment is removed. The proposal for general diagnostic criteria for the secondary headaches will be entered...... classification are then foreseen for the next 10 years. Until the printing of ICHD-IIR, the printed ICHD-II criteria remain in place for all other purposes. We issue a plea to the headache community to use and study these proposed general criteria for the secondary headaches in order to provide more evidence...

The challenge of the definition of early symptomatic knee osteoarthritis: a proposal of criteria and red flags from an international initiative promoted by the Italian Society for Rheumatology.

Science.gov (United States)

Migliore, Alberto; Scirè, Carlo Alberto; Carmona, Loreto; Herrero-Beaumont, Gabriel; Bizzi, Emanuele; Branco, Jaime; Carrara, Greta; Chevalier, Xavier; Collaku, Ledio; Aslanidis, Spiros; Denisov, Lev; Di Matteo, Luigi; Bianchi, Gerolamo; Diracoglu, Demirhan; Frediani, Bruno; Maheu, Emmanuel; Martusevich, Natalia; Bagnato, Gian Filippo; Scarpellini, Magda; Minisola, Giovanni; Akkoc, Nurullah; Ramonda, Roberta; Barskova, Tatiana; Babic-Naglic, Durda; Muelas, Jose Vicente Moreno; Ionescu, Ruxandra; Rashkov, Rasho; Damjanov, Nemanja; Cerinic, Marco Matucci

2017-08-01

The aim of this study was to establish consensus for potential early symptomatic knee osteoarthritis (ESKOA) clinical definition and referral criteria from primary care to rheumatologists, based on available data from literature and a qualitative approach, in order to perform studies on patients fulfilling such criteria and to validate the obtained ESKOA definition. A complex methodological approach was followed including: (1) three focus groups (FG), including expert clinicians, researchers and patients; (2) a systematic literature review (SLR); (3) two discussion groups followed by a Delphi survey. FG and SLR were performed in parallel to inform discussion groups in order to identify relevant constructs to be included in the modified Delphi survey. ESKOA is defined in the presence of: (a) two mandatory symptoms (knee pain in the absence of any recent trauma or injury and very short joint stiffness, lasting for less than 10 min, when starting movement) even in the absence of risk factors, or (b) knee pain, and 1 or 2 risk factors or (c) three or more risk factors in the presence of at least one mandatory symptom, with symptoms lasting less than 6 months. These criteria are applicable in the absence of active inflammatory arthritis, generalized pain, Kellgren-Lawrence grade >0, any recent knee trauma or injury, and age lower than 40 years. Knee pain in the absence of any recent trauma lasting for less than 6 months was considered as the referral criterion to the rheumatologist for the suspicion of ESKOA. This consensus process has identified provisional clinical definition of ESKOA and defined potential referral criterion to rheumatologist, in order to test ESKOA obtained definition in prospective validation studies.

Do Different Diagnostic Criteria Impact Polycystic Ovary Syndrome Diagnosis for Adolescents?

Science.gov (United States)

Akgül, Sinem; Düzçeker, Yasemin; Kanbur, Nuray; Derman, Orhan

2018-06-01

Although early diagnosis of polycystic ovary syndrome (PCOS) in adolescents might allow for earlier treatment and prevention of chronic disorders, incorrect or premature diagnosis carries risks of unnecessary treatment and psychological distress. There is no consensus concerning which diagnostic criteria to use for adolescents and current criteria vary. The objective of this study was to determine whether using different diagnostic criteria will affect PCOS diagnosis in adolescents. Fifty-two patients aged 13-18 years with at least 2 of the following criteria were included in the study: (1) oligomenorrhea or amenorrhea; (2) Clinical or biochemical hyperandrogenism; and (3) polycystic ovaries on ultrasonography. Patients were then categorized according to the 6 different criteria for PCOS. National Institutes of Health, Rotterdam criteria, Androgen Excess Society, Amsterdam criteria, Endocrine Society criteria, and the Pediatric Endocrine Society criteria. The characteristics of adolescents who were diagnosed with PCOS were also evaluated. Forty-one patients out of 52 (78.8%) received diagnosis with National Institutes of Health and Endocrine Society criteria, all with Rotterdam criteria, 45/52 (86.5%) with Androgen Excess Society criteria, 36/52 (69.2%) with Amsterdam criteria and 34/52 (65.4%) with the Pediatric Endocrine Society criteria. This study shows that the choice of guideline used does have a great effect on whether an adolescent received the PCOS diagnosis or not. For physicians using the broader criteria, care should be taken to ensure the patient does not receive diagnosis because of the physiological changes seen during puberty, which might mimic PCOS. For those using stricter criteria, close monitoring of patients who do not receive diagnosis is necessary to prevent chronic complications. Copyright © 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

Physiotherapy co-management of rheumatoid arthritis: identification of red flags, significance to clinical practice and management pathways.

Science.gov (United States)

Briggs, Andrew M; Fary, Robyn E; Slater, Helen; Ranelli, Sonia; Chan, Madelynn

2013-12-01

Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease. Physiotherapy interventions for people with RA are predominantly targeted at ameliorating disability resulting from articular and peri-articular manifestations of the disease and providing advice and education to improve functional capacity and quality of life. To ensure safe and effective care, it is critical that physiotherapists are able to identify potentially serious articular and peri-articular manifestations of RA, such as instability of the cervical spine. Additionally, as primary contact professionals, it is essential that physiotherapists are aware of the potentially serious extra-articular manifestations of RA. This paper provides an overview of the practice-relevant manifestations associated with RA that might warrant further investigation by a medical practitioner (red flags), their relevance to physiotherapy practice, and recommended management pathways. Copyright © 2013 Elsevier Ltd. All rights reserved.

Ferrocyanide Safety Program: Safety criteria for ferrocyanide watch list tanks

International Nuclear Information System (INIS)

Postma, A.K.; Meacham, J.E.; Barney, G.S.

1994-01-01

This report provides a technical basis for closing the ferrocyanide Unreviewed Safety Question (USQ) at the Hanford Site. Three work efforts were performed in developing this technical basis. The efforts described herein are: 1. The formulation of criteria for ranking the relative safety of waste in each ferrocyanide tank. 2. The current classification of tanks into safety categories by comparing available information on tank contents with the safety criteria; 3. The identification of additional information required to resolve the ferrocyanide safety issue

Criteria and evaluation of three decontamination techniques

Energy Technology Data Exchange (ETDEWEB)

Tripp, J.L.

1994-01-01

Past decontamination and solvent recovery activities at the Idaho Chemical Processing Plant (ICPP), which is part of the Idaho National Engineering Laboratory (INEL), have resulted in the accumulation of 1.5 million gallons of radioactively contaminated sodium-bearing liquid waste. Future decontamination activities at the ICPP could result in the production of 5 million gallons or more of sodium-bearing waste using the current decontamination techniques of chemical/water flushes and steam jet cleaning. This waste requires a large amount of cold chemical additive to process because the low melting temperatures of sodium and potassium salts cause agglomeration in the bed of the calciner vessel. Criteria have been established for evaluating methods and technologies available for decontaminating equipment and facilities. The criteria were weighted according to their relative importance using a Kepner-Tregoe Problem Solving process. These criteria were used to rank three decontamination techniques new to the ICPP: laser ablation, liquid abrasive blasting and CO{sub 2} pellet blasting, against the standard decontamination techniques of sodium-based chemical cleaning and water/steam jets used.

Criteria and evaluation of three decontamination techniques

International Nuclear Information System (INIS)

Tripp, J.L.

1994-01-01

Past decontamination and solvent recovery activities at the Idaho Chemical Processing Plant (ICPP), which is part of the Idaho National Engineering Laboratory (INEL), have resulted in the accumulation of 1.5 million gallons of radioactively contaminated sodium-bearing liquid waste. Future decontamination activities at the ICPP could result in the production of 5 million gallons or more of sodium-bearing waste using the current decontamination techniques of chemical/water flushes and steam jet cleaning. This waste requires a large amount of cold chemical additive to process because the low melting temperatures of sodium and potassium salts cause agglomeration in the bed of the calciner vessel. Criteria have been established for evaluating methods and technologies available for decontaminating equipment and facilities. The criteria were weighted according to their relative importance using a Kepner-Tregoe Problem Solving process. These criteria were used to rank three decontamination techniques new to the ICPP: laser ablation, liquid abrasive blasting and CO 2 pellet blasting, against the standard decontamination techniques of sodium-based chemical cleaning and water/steam jets used

Development of statewide geriatric patients trauma triage criteria.

Science.gov (United States)

Werman, Howard A; Erskine, Timothy; Caterino, Jeffrey; Riebe, Jane F; Valasek, Tricia

2011-06-01

The geriatric population is unique in the type of traumatic injuries sustained, physiological responses to those injuries, and an overall higher mortality when compared to younger adults. No published, evidence-based, geriatric-specific field destination criteria exist as part of a statewide trauma system. The Trauma Committee of the Ohio Emergency Medical Services (EMS) Board sought to develop specific criteria for geriatric trauma victims. A literature search was conducted for all relevant literature to determine potential, geriatric-specific, field-destination criteria. Data from the Ohio Trauma Registry were used to compare elderly patients, defined as age >70 years, to all patients between the ages of 16 to 69 years with regards to mortality risk in the following areas: (1) Glasgow Coma Scale (GCS) score; (2) systolic blood pressure (SBP); (3) falls associated with head, chest, abdominal or spinal injury; (4) mechanism of injury; (5) involvement of more than one body system as defined in the Barell matrix; and (6) co-morbidities and motor vehicle collision with one or more long bone fracture. For GCS score and SBP, those cut-off points with equal or greater risk of mortality as compared to current values were chosen as proposed triage criteria. For other measures, any criterion demonstrating a statistically significant increase in mortality risk was included in the proposed criteria. The following criteria were identified as geriatric-specific criteria: (1) GCS score trauma; (2) SBP trauma. In addition, these data suggested that elderly patients with specific co-morbidities be given strong consideration for evaluation in a trauma center. The state of Ohio is the first state to develop evidence-based geriatric-specific field-destination criteria using data from its state-mandated trauma registry. Further analysis of these criteria will help determine their effects on over-triage and under-triage of geriatric victims of traumatic injuries and the impact on the

An Investigation Into Design Criteria for Affordable Housing Supply

Directory of Open Access Journals (Sweden)

Olanrewaju Abdul Lateef

2017-01-01

Full Text Available Affordable housing provision constitutes a very large scheme in any countries due to income distribution and national development. The supply of housing depends on many activities and processes. The purpose of the houses is to meet the requirement of the householders therefore design criteria must address the users’ requirements. The establishment of the design criteria constitutes an important activity at the initial phase of the housing development. The design criteria are prepared by the design team in collaboration with many stakeholders especially the householders. Housinsg design criteria are the requirements that must be considered prior to construction of the housing. Lack of adequate information on the design criteria would lead to poor householders’ satisfactions, increase in maintenance cost, abandonments and completed but not occupy housing. In Malaysia, many of these consequences are prevalent. However, while information on the house owners’ requirements is inconclusive, this current research set out to investigate the design criteria of affordable housing. The increase in the affordable housing gap in Malaysia can be reduced if the designers have a comprehensive understanding of users’ requirements and the design criteria. Through a cross sectional survey questionnaire, comprising 25 criteria, 7 criteria were found to be extremely critical. The Kaiser-Meyer-Olkin measure of sampling adequacy indicated that the strength of the relationships among variables was strong (KMO =0.716. Bartlett’s test of sphericity, which tests the overall significance of all the correlations within the correlation matrix, was significant χ2 (325 = 1825.075, p<0.001, indicating the data were drawn from the same population and that the criteria were related.Sustainability considerations are now being considered by the providers of affordable housing. Deductively, the results lead to the conclusion that a major factor responsible for the poor

VizieR Online Data Catalog: Redshift reliability flags (VVDS data) (Jamal+, 2018)

Science.gov (United States)

Jamal, S.; Le Brun, V.; Le Fevre, O.; Vibert, D.; Schmitt, A.; Surace, C.; Copin, Y.; Garilli, B.; Moresco, M.; Pozzetti, L.

2017-09-01

The VIMOS VLT Deep Survey (Le Fevre et al. 2013A&A...559A..14L) is a combination of 3 i-band magnitude limited surveys: Wide (17.5Machine Learning) a set of descriptors from individual zPDFs. In this paper, we exploit a set of 24519 spectra from the VVDS database. After computing zPDFs for each individual spectrum, a set of (8) descriptors of the zPDF are extracted to build a feature matrix X (dimension = 24519 rows, 8 columns). Then, we use a clustering (unsupervised algorithms in Machine Learning) algorithm to partition the feature space into distinct clusters (5 clusters: C1,C2,C3,C4,C5), each depicting a different level of confidence to associate with the measured redshift zMAP (Maximum-A-Posteriori estimate that corresponds to the maximum of the redshift PDF). The clustering results (C1,C2,C3,C4,C5) reported in the table are those used in the paper (Jamal et al, 2017) to present the new methodology of automating the zspec reliability assessment. In particular, we would like to point out that they were obtained from first tests conducted on the VVDS spectroscopic data (end of 2016). Therefore, the table does not depict immutable results (on-going improvements). Future updates of the VVDS redshift reliability flags can be expected. (1 data file).

Technological Criteria Technology-Environmental under a Systemic Approach: Chemistry Technology Transfer

OpenAIRE

Durán-García Martín Enrique

2014-01-01

Currently the transfer of chemical technology is a process that contributes to the technology policy of a country, an industry or an organization in general chemistry. This process requires the application of clear criteria for the proper development of the complex interrelations in the transfer of chemical technology. A group of criteria that are present, are those related to environmental technology which intrinsically define the technology and its impact to the environment. Therefore, the ...

NWTS program criteria for mined geologic disposal of nuclear wasite: site performance criteria

International Nuclear Information System (INIS)

1981-02-01

This report states ten criteria governing the suitability of sites for mined geologic disposal of high-level radioactive waste. The Department of Energy will use these criteria in its search for sites and will reevaluate their use when the Nuclear Regulatory Commission issues radioactive waste repository rules. These criteria encompass site geometry, geohydrology, geochemistry, geologic characteristics, tectonic environment, human intrusion, surface characteristics, environment, and potential socioeconomic impacts. The contents of this document include background discussion, site performance criteria, and appendices. The background section describes the waste disposal system, the application of the site criteria, and applicable criteria from NWTS-33(1) - Program Objectives, Functional Requirements and System Performance Criteria. Appendix A, entitled Comparison with Other Siting Criteria compares the NWTS criteria with those recommended by other agencies. Appendix B contains DOE responses to public comments received on the January 1980 draft of this document. Appendix C is a glossary

[Flag leaf photosynthetic characteristics, change in chlorophyll fluorescence parameters, and their relationships with yield of winter wheat sowed in spring].

Science.gov (United States)

Xu, Lan; Gao, Zhi-qang; An, Wei; Li, Yan-liang; Jiao, Xiong-fei; Wang, Chuang-yun

2016-01-01

With five good winter wheat cultivars selected from the middle and lower reaches of Yangtze River and Southwest China as test materials, a field experiment in Xinding basin area of Shanxi Province was conducted to study the photosynthetic characteristics, chlorophyll content, and chlorophyll fluorescence parameters of flag leaf at different sowing dates, as well as the correlations between these indices and yield for two years (2013-2014). The results showed that the difference in most fluorescence parameters except chlorophyll content among cultivars was significant. The correlations between these fluorescence parameters and yield were significant. The variation coefficient of chlorophyll (Chl) content was low (0.12-0.17), and that of performance index based on absorption (PIabs) was high (0.32-0.39), with the partial correlation coefficients of them with grain yield from 2013 to 2014 ranged in 0.70-0.81. Under the early sowing condition, the grain yield positively correlated with PIabs at flowering and filling stages and chlorophyll content at grain filling stage, but negatively correlated with the relative variable fluorescence at I point (Vi) at grain filling stage. About 81.1%-82.8% of grain yield were determined by the variations of PIabs, Chl, and Vi. Wheat cultivars had various performances in the treatments with different sowing dates and a consistent trend was observed in the two experimental years. Among these 5 cultivars, Yangmai 13 was suitable for early sowing, with the flag leaf photosynthetic rate (Pn), Chl, most fluorescence parame-ters, and grain yield showed obviously high levels. In conclusion, under early sowing condition chlorophyll content at grain filling stages, PIabs at flowering and filling stages, and Pn were important indices for selecting wheat cultivars with high photosynthetic efficiency.

How to know and choose online games: differences between current and potential players.

Science.gov (United States)

Teng, Ching-I; Lo, Shao-Kang; Wang, Pe-Cheng

2007-12-01

This study investigated how different adolescent players acquire game information and the criteria they use in choosing online games and found that (1) current players generally use comprehensive information sources more than potential players do; (2) current players rely on free trials and smooth display of motion graphics as choice criteria more than potential players do; (3) potential players rely on the look of advertisements more than current players do; (4) both current and potential players most likely use word-of-mouth and gaming programs on TV as information sources; and (5) endorser attractiveness is ranked the least important among six choice criteria by both current and potential players.

Transferability of habitat suitability criteria for fishes in warmwater streams

Science.gov (United States)

Freeman, Mary C.; Bowen, Z.H.; Crance, J.H.

1997-01-01

We developed habitat suitability criteria and tested their transferability for nine fishes inhabiting unregulated Piedmont and Coastal Plain streams in Alabama. Cr iteria for optimal habitat were defined as ranges of depth, velocity, substrate type and cover type for which a species' suitability index (proportional abundance divided by proportional habitat availability, scaled from 0 to 1) equalled or exceeded 0.4. We evaluated the transferability of criteria between study sites by testing the null hypothesis that species occurrence in a sample was independent of whether or not the sample was taken in optimal habitat. We also tested criteria transference to a large, flow-regulated river sampled during low flow periods. Depth, velocity and most substrate criteria developed for the bronze darter Percina palmaris successfully transferred between unregulated streams and to the flow-regulated river samples. All criteria developed for a pair of closely related, allopatric darter species, Etheostoma chuckwachattee and E. jordani, transferred sucessfully when applied between species (in the unregulated sites) and to the regulated river samples. In contrast, criteria for the Alabama shiner Cyprinella callistia failed nearly all tests of transferability. Criteria for E. stigmaeum, P. nigrofasciata, an undescribed Percina species, and a pair of related, allopatric Cyprinella species transferred inconsistently. The species with good criteria transference had high suitability indices for shallow depths, fast current velocities and coarse substrates, characteristic of riffle species. We suggest that microhabitat criteria for riffle fishes are more likely to provide a transferable measure of habitat quality than criteria for fishes that, although restricted to fluvial habitats, commonly occupy a variety of pool and riffle habitats.

77 FR 19391 - Notice of Proposed Intelligent Mail Indicia Performance Criteria With Request for Comments

Science.gov (United States)

2012-03-30

... POSTAL SERVICE Notice of Proposed Intelligent Mail Indicia Performance Criteria With Request for... replacement of the current Information-Based Indicia Performance Criteria (IBI PC) with new Intelligent Mail... the Payment Technology office. FOR FURTHER INFORMATION CONTACT: Marlo Kay Ivey, Business Programs...

Typical design/qualification acceptance criteria for newly installed pipelines and equipment components of VVER-type NPPs

International Nuclear Information System (INIS)

Masopust, R.

2003-01-01

This paper describes in general the typical design/qualification acceptance criteria and seismic acceptance criteria in particular that are applicable for important to safety newly installed pipelines and equipment components of VVER-type already existing NPPs, specifically during the design verification phase of this newly installed equipment. These criteria are currently used for VVER 440-213 and VVER 1000 NPPs in Czech Republic and in Slovakia. The similar criteria are also used in Hungary. (author)

Markers for nutrition studies: review of criteria for the evaluation of markers.

Science.gov (United States)

de Vries, Jan; Antoine, Jean-Michel; Burzykowski, Tomasz; Chiodini, Alessandro; Gibney, Mike; Kuhnle, Gunter; Méheust, Agnès; Pijls, Loek; Rowland, Ian

2013-10-01

Markers are important tools to assess the nutrition status and effects of nutrition interventions. There is currently insufficient consensus in nutrition sciences on how to evaluate markers, despite the need for properly evaluating them. To identify the criteria for the evaluation of markers related to nutrition, health and disease and to propose generic criteria for evaluation. The report on "Evaluation of Biomarker and Surrogate Endpoints in Chronic Disease" from the Institute of Medicine was the starting point for the literature search. Additionally, specific search strategies were developed for Pubmed. In nutrition, no set of criteria or systematic approach to evaluate markers is currently available. There is a reliance on the medical area where statistical methods have been developed to quantify the evaluation of markers. Even here, a systematic approach is lacking-markers are still evaluated on a case-by-case basis. The review of publications from the literature search resulted in a database with definitions, criteria for validity and the rationale behind the criteria. It was recognized that, in nutrition, a number of methodological aspects differ from medical research. The following criteria were identified as essential elements in the evaluation of markers: (1) the marker has a causal biological link with the endpoint, (2) there is a significant association between marker and endpoint in the target population, (3) marker changes consistently with the endpoint, e.g., in response to an intervention, and (4) change in the marker explains a substantial proportion of the change in the endpoint in response to the intervention.

Mammography image assessment; validity and reliability of current scheme

International Nuclear Information System (INIS)

Hill, C.; Robinson, L.

2015-01-01

Mammographers currently score their own images according to criteria set out by Regional Quality Assurance. The criteria used are based on the ‘Perfect, Good, Moderate, Inadequate’ (PGMI) marking criteria established by the National Health Service Breast Screening Programme (NHSBSP) in their Quality Assurance Guidelines of 2006 1 . This document discusses the validity and reliability of the current mammography image assessment scheme. Commencing with a critical review of the literature this document sets out to highlight problems with the national approach to the use of marking schemes. The findings suggest that ‘PGMI’ scheme is flawed in terms of reliability and validity and is not universally applied across the UK. There also appear to be differences in schemes used by trainees and qualified mammographers. Initial recommendations are to be made in collaboration with colleagues within the National Health Service Breast Screening Programme (NHSBSP), Higher Education Centres, College of Radiographers and the Royal College of Radiologists in order to identify a mammography image appraisal scheme that is fit for purpose. - Highlights: • Currently no robust evidence based marking tools in use for the assessment of images in mammography. • Is current system valid, reliable and robust? • How can the current image assessment tool be improved? • Should students and qualified mammographers use the same tool? • What marking criteria are available for image assessment?

Which Diagnostic Criteria are Most Useful in Discriminating Between Social Gamblers and Individuals with Gambling Problems? An Examination of DSM-IV and DSM-5 Criteria.

Science.gov (United States)

Temcheff, Caroline E; Paskus, Thomas S; Potenza, Marc N; Derevensky, Jeffrey L

2016-09-01

The current study sought to identify which diagnostic criteria for gambling disorder have the greatest ability to differentiate between social and problem gamblers. This study was conducted on a sample of male and female college student athletes across the U.S. (n = 8674). Classification and regression tree analysis represents an appropriate technique when addressing the question of an item's diagnostic value, as it sequentially selects variables to isolate sets of observations with similar outcomes. The current results suggest that the item related to preoccupation ("Have there been periods in the past year where you spent a lot of time thinking about gambling?") was the DSM-5 item best able to differentiate between male and female social and problem gamblers in this sample. When considering only the nine criteria retained in the DSM-5, three criteria were identified as key for distinguishing between social and disordered gamblers among men, and one criterion was identified for distinguishing between groups of women. In addition, these results do not support the notion that the illegal acts criterion has a particularly low base rate and found that it can be an important indicator of disordered gambling in a college-aged sample.

Development of criteria and standards for management of low-level radioactive waste

International Nuclear Information System (INIS)

Grey, A.E.; Falconer, K.L.

1980-08-01

The basic need for criteria and standards for radioactive waste management is to ensure compliance with Federal and State regulations applicable to this activity. In addition, criteria and standards can establish the parameters by which a radioactive waste disposal site is selected, the form in which the waste is to be disposed, how a disposal site is to be operated, and how that site is to be closed when it reaches the end of its useful life. For developing criteria and standards, this report discusses the nature of low-level radioactive waste and the role government agencies play in regulating its management. It describes subject areas for which criteria and standards could be developed, current and evolving requirements, and future suggested analyses

F-Area Acid/Caustic Basin groundwater monitoring report. Second quarter 1994

International Nuclear Information System (INIS)

1994-09-01

During second quarter 1994, samples from the FAC monitoring wells at the F-Area Acid/Caustic Basin were collected and analyzed for herbicides/pesticides, indicator parameters, metals, nitrate, radionuclide indicators, volatile organic compounds, and other constituents. Piezometer FAC 5P and monitoring well FAC 6 were dry and could not be sampled. Analytical results that exceeded final Primary Drinking Water Standards (PDWS), other Savannah River Site (SRS) Flag 2 criteria, or the SRS turbidity standard of 50 NTU during the quarter were as follows: gross alpha exceeded the final PDWS and aluminum, iron, manganese, and total organic halogens exceeded the SRS Flag 2 criteria in one or more of the FAC wells. Turbidity exceeded the SRS standard in well FAC 3. Groundwater flow direction and rate in the water table beneath the F-Area Acid/Caustic Basin were similar to past quarters

Ventilation criteria for IDMS facility

International Nuclear Information System (INIS)

Lambert, D.P.

1996-01-01

Both Facility Evaluation Board (FEB) reviews of the Integrated DWPF Melter System (IDMS) have identified the inconsistency of the current IDMS Process Hazards Review (PHR) versus actual IDMS practice as regards the criteria to contain air borne pollutants that may be present in the Process Room (e.g. benzene and mercury). The PHR states that a 1.0 in. wc pressure differential be maintained between the IDMS Process Room and Building 672-T. In addition, the PHR further specifies that the linear velocity through openings into the Process Room (e.g. open doors) be equal to or greater than 150 fpm. Finally, the PHR recommended that mercury vapor and benzene monitors be installed in the Process Room ventilation exhaust to alert personnel to the presence of vapors of benzene and/or mercury before entering the Process Room. This report summarizes the results of reassessment of these criteria and the specific recommendation for permanent installation of mercury and benzene vapor monitors in the vapor exhaust of the Process Room

Performance of classification criteria for gout in early and established disease

DEFF Research Database (Denmark)

Taylor, William J; Fransen, Jaap; Dalbeth, Nicola

2016-01-01

OBJECTIVES: To compare the sensitivity and specificity of different classification criteria for gout in early and established disease. METHODS: This was a cross-sectional study of consecutive rheumatology clinic patients with joint swelling in which gout was defined by presence or absence...... of monosodium urate crystals as observed by a certified examiner at presentation. Early disease was defined as patient-reported onset of symptoms of 2 years or less. RESULTS: Data from 983 patients were collected and gout was present in 509 (52%). Early disease was present in 144 gout cases and 228 non.......3%/84.4% and 86.4%/63.6%. Criteria not requiring synovial fluid analysis had sensitivity and specificity of less than 80% in early and established disease. CONCLUSIONS: Existing classification criteria for gout have sensitivity of over 80% in early and established disease but currently available criteria that do...

Plutonium storage criteria

Energy Technology Data Exchange (ETDEWEB)

Chung, D. [Scientech, Inc., Germantown, MD (United States); Ascanio, X. [Dept. of Energy, Germantown, MD (United States)

1996-05-01

The Department of Energy has issued a technical standard for long-term (>50 years) storage and will soon issue a criteria document for interim (<20 years) storage of plutonium materials. The long-term technical standard, {open_quotes}Criteria for Safe Storage of Plutonium Metals and Oxides,{close_quotes} addresses the requirements for storing metals and oxides with greater than 50 wt % plutonium. It calls for a standardized package that meets both off-site transportation requirements, as well as remote handling requirements from future storage facilities. The interim criteria document, {open_quotes}Criteria for Interim Safe Storage of Plutonium-Bearing Solid Materials{close_quotes}, addresses requirements for storing materials with less than 50 wt% plutonium. The interim criteria document assumes the materials will be stored on existing sites, and existing facilities and equipment will be used for repackaging to improve the margin of safety.

Technological Criteria Technology-Environmental under a Systemic Approach: Chemistry Technology Transfer

Directory of Open Access Journals (Sweden)

Durán-García Martín Enrique

2014-07-01

Full Text Available Currently the transfer of chemical technology is a process that contributes to the technology policy of a country, an industry or an organization in general chemistry. This process requires the application of clear criteria for the proper development of the complex interrelations in the transfer of chemical technology. A group of criteria that are present, are those related to environmental technology which intrinsically define the technology and its impact to the environment. Therefore, the transfer of chemical technology requires technological-environmental criteria defining, in conjunction with other criteria, an adequate process for the selection, acquisition and incorporation of technology in a holistic perspective, so it provides feasible solutions the chemical industry in pursuit of their goals. Then the criterion becomes a benchmark for assessing an appropriate technology transfer process. We performed a theoretical analysis of the technological and environmental criteria, proposing thirty-six (36 technological-environmental criteria interrelated under a systemic approach in the process of transfer of chemical technology, focused on a methodological cycle first run, based primarily on the research-action method. Future research is expected to make a refinement of the criteria from the formulation and validation of metrics so that necessary adjustments are made to optimize the process of transfer of chemical technology.

IMPORTANCE OF MULTIPLE CRITERIA FOR PRIORITY SETTING OF HIV/AIDS INTERVENTIONS.

Science.gov (United States)

Tromp, Noor; Prawiranegara, Rozar; Siregar, Adiatma; Sunjaya, Deni; Baltussen, Rob

2015-01-01

This study describes the views of various stakeholders on the importance of different criteria for priority setting of HIV/AIDS interventions in Indonesia. Based on a general list of criteria and a focus group discussion with stakeholders (n = 6), a list was developed of thirty-two criteria that play a role in priority setting in HIV/AIDS control in West-Java province. Criteria were categorized according to the World Health Organization's health system goals and building block frameworks. People living with HIV/AIDS (n = 49), healthcare workers (HCW) (n = 41), the general population (n = 43), and policy makers (n = 22) rated the importance of thirty-two criteria on a 5-point Likert-scale. Thereafter, respondents ranked the highest rated criteria to express more detailed preferences. Stakeholders valued the following criteria as most important for the priority setting of HIV/AIDS interventions: an intervention's impact on the HIV/AIDS epidemic, reduction of stigma, quality of care, effectiveness on individual level, and feasibility in terms of current capacity of the health system (i.e., HCW, product, information, and service requirements), financial sustainability, and acceptance by donors. Overall, stakeholders' preferences for the importance of criteria are similar. Our study design outlines an approach for other settings to identify which criteria are important for priority setting of health interventions. For Indonesia, these study results may be used in priority setting processes for HIV/AIDS control and may contribute to more transparent and systematic allocation of resources.

Clinical Implications of Various Criteria for the Biochemical Diagnosis of Insulinoma

Directory of Open Access Journals (Sweden)

Chang Ho Ahn

2014-12-01

Full Text Available BackgroundAmong the various diagnostic criteria for insulinoma, the ratio criteria have been controversial. However, the amended insulin-glucose ratio exhibited excellent diagnostic performance in a recent retrospective cohort study, although it has not yet been validated in other patient cohorts. We examined the diagnostic performance of the current criteria of the Endocrine Society, insulin-glucose ratio, C-peptide-glucose ratio, and amended ratios in terms of differentiating insulinomas.MethodsWe reviewed the medical records of patients who underwent evaluation for hypoglycemia from 2000 to 2013. Fourteen patients with histopathologically confirmed insulinoma and 18 patients without clinical evidence of insulinoma were included. The results of a prolonged fast test were analyzed according to the abovementioned criteria.ResultsFulfilling all three Endocrine Society criteria-plasma levels of glucose (24.0 (pmol/L/(mmol/L] gave the highest area under the receiver operating characteristic curve, with 93% sensitivity and 94% specificity.ConclusionFulfilling the glucose, insulin, and C-peptide criteria of the Endocrine Society guidelines exhibited the best diagnostic performance for insulinoma. Nonetheless, the insulin-glucose ratio may still have a role in the biochemical diagnosis of insulinoma.

Classification of methods for measuring current-voltage characteristics of semiconductor devices

Directory of Open Access Journals (Sweden)

Iermolenko Ia. O.

2014-06-01

Full Text Available It is shown that computer systems for measuring current-voltage characteristics are very important for semiconductor devices production. The main criteria of efficiency of such systems are defined. It is shown that efficiency of such systems significantly depends on the methods for measuring current-voltage characteristics of semiconductor devices. The aim of this work is to analyze existing methods for measuring current-voltage characteristics of semiconductor devices and to create the classification of these methods in order to specify the most effective solutions in terms of defined criteria. To achieve this aim, the most common classifications of methods for measuring current-voltage characteristics of semiconductor devices and their main disadvantages are considered. Automated and manual, continuous, pulse, mixed, isothermal and isodynamic methods for measuring current-voltage characteristics are analyzed. As a result of the analysis and generalization of existing methods the next classification criteria are defined: the level of automation, the form of measurement signals, the condition of semiconductor device during the measurements, and the use of mathematical processing of the measurement results. With the use of these criteria the classification scheme of methods for measuring current-voltage characteristics of semiconductor devices is composed and the most effective methods are specified.

Psychiatric comorbidity, red flag behaviors, and associated outcomes among office-based buprenorphine patients following Hurricane Sandy.

Science.gov (United States)

Williams, Arthur R; Tofighi, Babak; Rotrosen, John; Lee, Joshua D; Grossman, Ellie

2014-04-01

supply disruption, (3) a pre-storm history of red flag behaviors (in particular, repeat opioid-positive urines), and (4) new-onset post-storm psychiatric symptoms. Our findings highlight the relative resilience of buprenorphine as an office-based treatment modality for patients encountering a disaster with associated unanticipated service disruption. In responding to future disasters, triaging patient contact and priority based on a history of red-flag behaviors, rather than a history of psychiatric comorbidity, will likely optimize resource allocation, especially among recently enrolled patients. Additionally, patients endorsing new-onset psychiatric manifestations following disasters may be an especially high-risk group for poor outcomes, warranting further study.

Ecological radiation protection criteria for nuclear power

International Nuclear Information System (INIS)

Kryshev, I.I.

1993-01-01

By now a large quantity of radioactive hazards of all sizes and shapes has accumulated in Russia. They include RBMK, VVER, and BN (fast-neutron) nuclear power plants, nuclear fuel processing plants, radioactive waste dumps, ships with nuclear power units, etc. In order to evaluate the radioecological situation correctly, the characteristics of the radioactive contamination must be compiled in these areas with some system of criteria which will provide an acceptable level of ecological safety. Currently health criteria for radiation protection are, which are oriented to man's radiation protection, predominate. Here the concept of a thresholdless linear dose-response dependence, which has been confirmed experimentally only at rather high doses (above 1 Gy), is taken as the theoretical basis for evaluating and normalizing radiation effects. According to one opinion, protecting people against radiation is sufficient to protect other types of organisms, although they are not necessarily of the same species. However, from the viewpoint of ecology, this approach is incorrect, because it does not consider radiation dose differences between man and other living organisms. The article discusses dose-response dependences for various organisms, biological effects of ionizing radiation, and appropriate radiation protection criteria

A critical review of "Internet addiction" criteria with suggestions for the future.

Science.gov (United States)

Van Rooij, Antonius J; Prause, Nicole

2014-12-01

In the last 5 years a deluge of articles on the topic of Internet addiction (IA) has proposed many candidate symptoms as evidence of this proposed disease. We critically reviewed the current approach to the measurement and identification of this new excessive behavior syndrome. Three popular models of IA were discussed: Griffith’s components model; Young’s Internet Addiction Test (IAT); and the criteria by Tao et al. (2010). We selected these models because they are widely cited and propose specific criteria for IA disorder. Our approach is not meant to provide an exhaustive review, but to discuss and critique the most salient trends in the field. The models of Internet addiction share some criteria, including feeling a loss of control over Internet use; ensuing psychological, social, or professional conflict or problems; and preoccupation when not using the Internet. Other criteria inconsistently mentioned include: mood management, tolerance, withdrawal, and craving/anticipation. The models studied here share the assumption that the Internet can produce a qualitative shift to a diseased state in humans. We critically discussed the above criteria and concluded that the evidence base is currently not strong enough to provide support for an Internet addiction disorder. Future research areas are suggested: (1) Focusing on common impaired dimensions, (2) exploring neuroimaging as a model building tool, and (3) identifying shifts in the rewarding aspects of Internet use. Given the lack of consensus on the subject of Internet addiction, a focus on problem behaviors appears warranted.

Development and validation of sustainability criteria of administrative green schools in Iran.

Science.gov (United States)

Meiboudi, Hossein; Lahijanian, Akramolmolok; Shobeiri, Seyed Mohammad; Jozi, Seyed Ali; Azizinezhad, Reza

2017-07-15

Environmental responsibility in school has led to the emergence of a variety of criteria to administer green schools' contributions to sustainability. Sustainability criteria of administrative green schools need validity, reliability and norms. The aim of the current study was to develop and validate assessment criteria for green schools in Iran based on the role of academia. A national survey was conducted to obtain data on sustainability criteria initiatives for green schools and the Iranian profile was defined. An initial pool of 71 items was generated and after its first edition, 63 items were selected to comprise the sustainability criteria. Engineering-architectural and behavioral aspects of this sustainability criteria were evaluated through a sample of 1218 graduate students with environmental degrees from Iran's universities. Exploratory factor analysis using principal components and promax rotation method showed that these 9 criteria have simple structures and are consistent with the theoretical framework. The reliability coefficients of subscales ranged between 0.62 (participation) and 0.84 (building location and position). The study's survey of correlation coefficients between items and subscales illustrated that those coefficients varied between 0.24 and 0.68. Copyright © 2017 Elsevier Ltd. All rights reserved.

The challenges of simulating wake vortex encounters and assessing separation criteria

Science.gov (United States)

Dunham, R. E.; Stuever, Robert A.; Vicroy, Dan D.

1993-01-01

During landings and take-offs, the longitudinal spacing between airplanes is in part determined by the safe separation required to avoid the trailing vortex wake of the preceding aircraft. Safe exploration of the feasibility of reducing longitudinal separation standards will require use of aircraft simulators. This paper discusses the approaches to vortex modeling, methods for modeling the aircraft/vortex interaction, some of the previous attempts of defining vortex hazard criteria, and current understanding of the development of vortex hazard criteria.

Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations

Science.gov (United States)

Ramos-Méndez, José; Schuemann, Jan; Incerti, Sebastien; Paganetti, Harald; Schulte, Reinhard; Faddegon, Bruce

2017-08-01

Flagged uniform particle splitting was implemented with two methods to improve the computational efficiency of Monte Carlo track structure simulations with TOPAS-nBio by enhancing the production of secondary electrons in ionization events. In method 1 the Geant4 kernel was modified. In method 2 Geant4 was not modified. In both methods a unique flag number assigned to each new split electron was inherited by its progeny, permitting reclassification of the split events as if produced by independent histories. Computational efficiency and accuracy were evaluated for simulations of 0.5-20 MeV protons and 1-20 MeV u-1 carbon ions for three endpoints: (1) mean of the ionization cluster size distribution, (2) mean number of DNA single-strand breaks (SSBs) and double-strand breaks (DSBs) classified with DBSCAN, and (3) mean number of SSBs and DSBs classified with a geometry-based algorithm. For endpoint (1), simulation efficiency was 3 times lower when splitting electrons generated by direct ionization events of primary particles than when splitting electrons generated by the first ionization events of secondary electrons. The latter technique was selected for further investigation. The following results are for method 2, with relative efficiencies about 4.5 times lower for method 1. For endpoint (1), relative efficiency at 128 split electrons approached maximum, increasing with energy from 47.2  ±  0.2 to 66.9  ±  0.2 for protons, decreasing with energy from 51.3  ±  0.4 to 41.7  ±  0.2 for carbon. For endpoint (2), relative efficiency increased with energy, from 20.7  ±  0.1 to 50.2  ±  0.3 for protons, 15.6  ±  0.1 to 20.2  ±  0.1 for carbon. For endpoint (3) relative efficiency increased with energy, from 31.0  ±  0.2 to 58.2  ±  0.4 for protons, 23.9  ±  0.1 to 26.2  ±  0.2 for carbon. Simulation results with and without splitting agreed within 1% (2 standard

Development of the Solar System Concept Inventory

Science.gov (United States)

Hornstein, S.; Prather, E.

2009-12-01

Concept inventories can provide useful insight into students’ understanding of key physical concepts. Knowing what your students have learned during a course is a valuable tool for improving your own teaching. Unfortunately, current astronomy concept inventories are not suitable for an introductory solar system course because they either cover too broad of a range of topics (e.g. Astronomy Diagnostic Test) or are too narrowly focused (e.g. Greenhouse Effect Concept Inventory, Lunar Phase Concept Inventory). We have developed the Solar System Concept Inventory (SSCI) to cover those topics commonly taught in an introductory solar system course. The topics included on the SSCI were selected by having faculty identify the key concepts they address when teaching about the solar system. SSCI topics include formation mechanisms, planetary interiors, atmospheric effects, and small solar system bodies. Student interviews were conducted to identify common naive ideas and reasoning difficulties relating to these key topics. The SSCI has been through two semesters of national, multi-institutional field-testing, involving over 1500 students. After the first semester of testing, question statistics were used to flag ineffective questions and flagged questions were revised or eliminated. We will present an overall outline of the SSCI development as well as our question-flagging criteria and question analyses from the latest round of field-testing. We would like to thank the NSF for funding under Grant No. 0715517, a CCLI Phase III Grant for the Collaboration of Astronomy Teaching Scholars (CATS) Program.

Design criteria and pressure vessel codes - an American view

International Nuclear Information System (INIS)

Tuppeny, W.H.

1975-01-01

To the pressure vessel designer, codes and criteria represent the common ground where the stress analyst and the metallurgist must interact and evolve rules and procedures which will ensure safety and open-ended responsiveness to technological, economic, and environmental change. The paper briefly discusses the evolution and rationale behind the current ASME code sections -emphasizing those portions applicable to designs operating in the creep range. The author then proposes a plan of action so that the analysts and materials people can make optimum use of time and resources, and evolve data and design criteria which will be responsive to changing technology and the economic and safety requirements of the future. (author)

Most Scottish neurologists do not apply the 2010 McDonald criteria when diagnosing multiple sclerosis.

Science.gov (United States)

Lumley, R; Davenport, R; Williams, A

2015-03-01

The diagnostic criteria for multiple sclerosis have evolved over time and currently the 2010 McDonald criteria are the most widely accepted. These criteria allow the diagnosis of multiple sclerosis to be made at the clinically isolated syndrome stage provided certain criteria are met on a single magnetic resonance brain scan. Our hypothesis was that neurologists in Scotland did not use these criteria routinely. We sent a SurveyMonkey questionnaire to all Scottish neurologists (consultants and trainees) regarding the diagnosis of multiple sclerosis. Our questionnaire response rate was 65/99 (66%). Most Scottish neurologists were aware of the criteria and 31/58 (53%) felt that they were using these routinely. However, in a clinical vignette designed to test the application of these criteria, only 5/57 (9%) of neurologists appeared to use them. Scottish neurologists' use of the 2010 McDonald criteria for diagnosis of multiple sclerosis varies from practitioners' perception of their use of these criteria.

Multi-criteria clinical decision support: A primer on the use of multiple criteria decision making methods to promote evidence-based, patient-centered healthcare.

Science.gov (United States)

Dolan, James G

2010-01-01

Current models of healthcare quality recommend that patient management decisions be evidence-based and patient-centered. Evidence-based decisions require a thorough understanding of current information regarding the natural history of disease and the anticipated outcomes of different management options. Patient-centered decisions incorporate patient preferences, values, and unique personal circumstances into the decision making process and actively involve both patients along with health care providers as much as possible. Fundamentally, therefore, evidence-based, patient-centered decisions are multi-dimensional and typically involve multiple decision makers.Advances in the decision sciences have led to the development of a number of multiple criteria decision making methods. These multi-criteria methods are designed to help people make better choices when faced with complex decisions involving several dimensions. They are especially helpful when there is a need to combine "hard data" with subjective preferences, to make trade-offs between desired outcomes, and to involve multiple decision makers. Evidence-based, patient-centered clinical decision making has all of these characteristics. This close match suggests that clinical decision support systems based on multi-criteria decision making techniques have the potential to enable patients and providers to carry out the tasks required to implement evidence-based, patient-centered care effectively and efficiently in clinical settings.The goal of this paper is to give readers a general introduction to the range of multi-criteria methods available and show how they could be used to support clinical decision-making. Methods discussed include the balance sheet, the even swap method, ordinal ranking methods, direct weighting methods, multi-attribute decision analysis, and the analytic hierarchy process (AHP).

Developmental trauma disorder: pros and cons of including formal criteria in the psychiatric diagnostic systems

Directory of Open Access Journals (Sweden)

Schmid Marc

2013-01-01

Full Text Available Abstract Background This article reviews the current debate on developmental trauma disorder (DTD with respect to formalizing its diagnostic criteria. Victims of abuse, neglect, and maltreatment in childhood often develop a wide range of age-dependent psychopathologies with various mental comorbidities. The supporters of a formal DTD diagnosis argue that post-traumatic stress disorder (PTSD does not cover all consequences of severe and complex traumatization in childhood. Discussion Traumatized individuals are difficult to treat, but clinical experience has shown that they tend to benefit from specific trauma therapy. A main argument against inclusion of formal DTD criteria into existing diagnostic systems is that emphasis on the etiology of the disorder might force current diagnostic systems to deviate from their purely descriptive nature. Furthermore, comorbidities and biological aspects of the disorder may be underdiagnosed using the DTD criteria. Summary Here, we discuss arguments for and against the proposal of DTD criteria and address implications and consequences for the clinical practice.

Design criteria development for the structural stability of nuclear waste repository

Energy Technology Data Exchange (ETDEWEB)

Yun, C H [Korea Institute of Nuclear Safety, Taejon (Korea, Republic of); Yu, T S [Daewoo Engineering Company, Sungnam (Korea, Republic of); Ko, H M [Seoul National Univ., Seoul (Korea, Republic of)

1990-11-15

The objective of the present project is to develop design criteria for the structural stability of rock cavity for the underground repository are defined, according to which detailed descriptions for design methodologies, design stages and stability analysis of the cavity are made. The proposed criteria can be used as a guide for the preparation of design codes which are to be established as the site condition and technical emplacement procedure are fixed. The present report first reviews basic safety requirements and criteria of the underground disposal of nuclear wastes for the establishment of design concepts and stability analysis of the rock cavity. Important factors for the design are also described by considering characteristics of the wastes and underground facilities. The present project has investigated technical aspects on the design of underground structures based on the currently established underground construction technologies, and presented a proposal for design criteria for the structural stability of the nuclear waste repository. The proposed criteria consist of general provisions, geological exploration, rock classification, design process and methods, supporting system, analyses and instrumentation.

The use of economic criteria in providing a basis for safe reactor operation

International Nuclear Information System (INIS)

Graham, J.

1989-01-01

Probabilistic criteria based upon an acceptance measure of protection for owner investment can complete the range of design probabilistic criteria between those set by acceptance public safety and those set by acceptable reliability in plant operation. Criteria which address the protection of owner investment have the benefit of lowering risk in adjacent risk regions by providing greater reliability in operation as well as less risk to the safety of the public and the environment. Such investment protection criteria are currently being used to extend plant life but they could also be used very beneficially as part of the initial design process. In this paper trial criteria are suggested which address the risk of extended plant shutdown with the resultant necessity to purchase replacement power, and the risk of replacement of expensive plant components. Additional financial assessment is required to ensure that there is a proper correlation between acceptable measures of owner-investment protection and the levels of probabilistic defence suggested, but the trial criteria proposed can be used as important practical design criteria

Clinical diagnostic criteria for typical and atypical variants of Rett syndrome in children

Directory of Open Access Journals (Sweden)

S. Ya. Volgina

2016-01-01

Full Text Available Rett Syndrome is one of the most socially significant neuropsychiatric hereditary diseases in children. This syndrome is mainly found in girls: its frequency is 1:10000–15000. Currently mutations in X-linked gene MESR2 considered as the main cause of the syndrome. Diagnosis of typical and atypical variants of the syndrome is based on the use of clinical criteria, determining gene mutations МЕСР2, CDKL5 and FOXG1. In 2010, the Expert Consortium for Rett syndrome have revised the existing diagnostic criteria for the syndrome and come to a new consensus. If there is a regression of mental development for the diagnosis of Rett syndrome exemplary embodiment only four basic criteria for the diagnosis of atypical variant — two of the four main criteria, and five of the eleven additional criteria. 

Productive Regions: Criteria and Classification

Directory of Open Access Journals (Sweden)

Vlasyuk L. I.

2012-03-01

Full Text Available An official statistical dataset for 80 territorial subjects of the Russian Federation for 2000, 2007 and 2009 has proved the hypothesis that, under the neoclassical concept, the resources move to regions with the highest marginal productivity of the factors of production, which leads to the accumulation of investment resources, while providing financial and social efficiency. Based on cluster analysis by three performance criteria, productive regions are identified, which are dominated by regions productive in the extraction of minerals. It is shown that the stability of the factors’ distribution in space determines the current and future specialization of regional economies

Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders

DEFF Research Database (Denmark)

Peck, C C; Goulet, J-P; Lobbezoo, F

2014-01-01

There is a need to expand the current temporomandibular disorders' (TMDs) classification to include less common but clinically important disorders. The immediate aim was to develop a consensus-based classification system and associated diagnostic criteria that have clinical and research utility f...

Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders

NARCIS (Netherlands)

Peck, C.C.; Goulet, J-P; Lobbezoo, F.; Schiffman, E.L.; Alstergren, P.; Anderson, G.C.; De Leeuw, R.; Jensen, R.; Michelotti, A.; Ohrbach, R.; Petersson, A.; List, T.

2014-01-01

There is a need to expand the current temporomandibular disorders' (TMDs) classification to include less common but clinically important disorders. The immediate aim was to develop a consensus-based classification system and associated diagnostic criteria that have clinical and research utility for

The impact of endorsing Spitzer's proposed criteria for PTSD in the forthcoming DSM-V on male and female Veterans.

Science.gov (United States)

Miller, Lyndsey N; Chard, Kathleen M; Schumm, Jeremiah A; O'Brien, Carol

2011-06-01

This study explored differences between Spitzer's proposed model of posttraumatic stress disorder (PTSD) and the current DSM-IV diagnostic classification scheme in 353 Veterans. The majority of Veterans (89%) diagnosed with PTSD as specified in the DSM-IV also met Spitzer's proposed criteria. Veterans who met both DSM-IV and Spitzer's proposed criteria had significantly higher Clinician Administered PTSD Scale severity scores than Veterans only meeting DSM-IV criteria. Logistic regression indicated that being African American and having no comorbid diagnosis of major depressive disorder or history of a substance use disorder were found to predict those Veterans who met current, but not proposed criteria. These findings have important implications regarding proposed changes to the diagnostic classification criteria for PTSD in the forthcoming DSM-V. Copyright © 2011 Elsevier Ltd. All rights reserved.

Tube Plugging Criteria for the High-pressure Heaters of Nuclear Power Plant

Energy Technology Data Exchange (ETDEWEB)

Kim, Hyungnam; Cho, Nam-Cheoul; Lee, Kuk-hee [KHNP Central Research Institute, Daejeon (Korea, Republic of)

2015-10-15

In this paper, a method to establish the tube plugging criteria of BOP heat exchangers is introduced and the tube plugging criteria for the high pressure heaters of a nuclear power plant. This method relies on the similar plugging criteria used in the steam generator tubes. Power generation field urges nuclear power plants to reduce operating and maintaining costs to remain competitive. To reduce the cost by means of preventing the lowering thermal efficiency, the inspection of balance-of-plant heat exchanger, which was treated as not important work, becomes important. The tubing materials and tube thickness of heat exchangers in nuclear power plants are selected to withstand system temperature, pressure, and corrosion. But tubes have experienced leaks and failures and plugged based upon eddy current testing (ET) results. There are some problems for plugging the heat exchanger tubes since the criterion and its basis are not clearly described. For this reason, the criteria for the tube wall thickness are addressed in order to operate the heat exchangers in nuclear power plant without trouble during the cycle. The feed water heater is a kind of heat exchanger which raises the temperature of water supplied from the condenser. The heat source of high-pressure heaters is the extraction steam from the high-pressure turbine and moisture separator re-heater. If the tube wall of the heater is broken, the feed water flowing inside the tube intrudes to shell side. This forces the turbine to be stop in order to protect it. There are many codes and standards to be referred for calculating the minimum thickness of the heat exchanger tube in the designing stage. However, the codes and standards related to show the tube plugging criteria may not exist currently. A method to establish the tube plugging criteria of BOP heat exchangers is introduced and the tube plugging criteria for the high pressure heaters of Ulchin NPP No. 3 and 4. This method relies on the similar plugging

Imaging and diagnostic criteria for multiple sclerosis: are we there yet?

International Nuclear Information System (INIS)

Josey, Lawrence; Curley, Michael; Mousavi, Foroogh Jafari; Taylor, Bruce V.; Lucas, Robyn; Coulthard, Alan

2012-01-01

Excluding post traumatic injury, Multiple Sclerosis (MS) is the most common disabling neurological disorder of young adults. Although the effect on mortality is limited, the association of a young demographic and significant morbidity combine to make MS a devastating disease. Since MS was given its first detailed description in 1868, diagnostic criteria continue to evolve. Recently, there has been an international commitment to combine both clinical and paraclinical tests to arrive at an earlier diagnosis. Widespread acceptance of the use of MRI in diagnosis, monitoring and research has made the role of the radiologist more critical than ever in this disease. The primary diagnostic criteria for MS are the International Panel criteria, commonly referred to as the McDonald criteria and it is essential that the radiology community is aware of the work preceding these criteria, so that they are understood in the correct context and the importance acknowledged. Literature review utilising key word search to obtain the historical and current context of magnetic resonance imaging in the diagnosis of MS. A succinct description of the evolution of criteria for the diagnosis of MS. Radiologists must recognise that there are specific diagnostic criteria for MS that continue to evolve as a result of new research, improved technology and clinical experience and it is crucial that these criteria be applied in daily practice. It should be evident that diagnostic imaging criteria for MS will be most effective when combined with standardised MRI protocols such as those published by the international Consortium of Multiple Sclerosis Centres.

21 CFR 110.5 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 110.5 Section...) FOOD FOR HUMAN CONSUMPTION CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING, PACKING, OR HOLDING HUMAN FOOD General Provisions § 110.5 Current good manufacturing practice. (a) The criteria and...

South African medical schools: Current state of selection criteria and medical students' demographic profile.

Science.gov (United States)

van der Merwe, L J; van Zyl, G J; St Clair Gibson, A; Viljoen, M; Iputo, J E; Mammen, M; Chitha, W; Perez, A M; Hartman, N; Fonn, S; Green-Thompson, L; Ayo-Ysuf, O A; Botha, G C; Manning, D; Botha, S J; Hift, R; Retief, P; van Heerden, B B; Volmink, J

2015-12-16

Selection of medical students at South African (SA) medical schools must promote equitable and fair access to students from all population groups, while ensuring optimal student throughput and success, and training future healthcare practitioners who will fulfil the needs of the local society. In keeping with international practices, a variety of academic and non-academic measures are used to select applicants for medical training programmes in SA medical schools. To provide an overview of the selection procedures used by all eight medical schools in SA, and the student demographics (race and gender) at these medical schools, and to determine to what extent collective practices are achieving the goals of student diversity and inclusivity. A retrospective, quantitative, descriptive study design was used. All eight medical schools in SA provided information regarding selection criteria, selection procedures, and student demographics (race and gender). Descriptive analysis of data was done by calculating frequencies and percentages of the variables measured. Medical schools in SA make use of academic and non-academic criteria in their selection processes. The latter include indices of socioeconomic disadvantage. Most undergraduate medical students in SA are black (38.7%), followed by white (33.0%), coloured (13.4%) and Indian/Asian (13.6%). The majority of students are female (62.2%). The number of black students is still proportionately lower than in the general population, while other groups are overrepresented. Selection policies for undergraduate medical programmes aimed at redress should be continued and further refined, along with the provision of support to ensure student success.

Appropriate criteria set for personnel promotion across organizational levels using analytic hierarchy process (AHP

Directory of Open Access Journals (Sweden)

Charles Noven Castillo

2017-01-01

Full Text Available Currently, there has been limited established specific set of criteria for personnel promotion to each level of the organization. This study is conducted in order to develop a personnel promotion strategy by identifying specific sets of criteria for each level of the organization. The complexity of identifying the criteria set along with the subjectivity of these criteria require the use of multi-criteria decision-making approach particularly the analytic hierarchy process (AHP. Results show different sets of criteria for each management level which are consistent with several frameworks in literature. These criteria sets would help avoid mismatch of employee skills and competencies and their job, and at the same time eliminate the issues in personnel promotion such as favouritism, glass ceiling, and gender and physical attractiveness preference. This work also shows that personality and traits, job satisfaction and experience and skills are more critical rather than social capital across different organizational levels. The contribution of this work is in identifying relevant criteria in developing a personnel promotion strategy across organizational levels.

Development of optical fiber cable's inspection technology and maintenance criteria

International Nuclear Information System (INIS)

Kim, Min-Su; Ju, Hee-Wan; Shim, Seon-Heum; Lee, Youn-Ki; Kim, Jin-Il; Huh, Tae-Young

2008-01-01

Improve the reliability and establish the systematic maintenance methods for the digital control facilities' optical fiber cable, reviewed the technical requirements and the current maintenance procedures, analyzed the optical fiber cable's characteristics through actual test like bending, tension, attenuation. Based on the results of review, test and analysis, prepared the maintenance criteria and standard maintenance guideline. Also we verified those can be applied directly to the operating nuclear power plant through the actual test at Ulchin Unit 6. The details of test and analysis are presented in this paper. Also introduce the contents of maintenance criteria and guidelines

Admissions Criteria and Academic Performance in the AFIT Graduate Cost Analysis Program

National Research Council Canada - National Science Library

Garwood, Kenneth

2002-01-01

.... Using the cumulative graduate grade point average earned at AFIT as the measure of academic performance, comparisons were made between the predictive capability of the current criteria and other potential factors...

AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions

OpenAIRE

Paice, Judith A.; Mulvey, Matt; Bennett, Michael; Dougherty, Patrick M.; Farrar, John T.; Mantyh, Patrick W.; Miaskowski, Christine; Schmidt, Brian; Smith, Thomas J.

2016-01-01

Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the A...

Application fuzzy multi-attribute decision analysis method to prioritize project success criteria

Science.gov (United States)

Phong, Nguyen Thanh; Quyen, Nguyen Le Hoang Thuy To

2017-11-01

Project success is a foundation for project owner to manage and control not only for the current project but also for future potential projects in construction companies. However, identifying the key success criteria for evaluating a particular project in real practice is a challenging task. Normally, it depends on a lot of factors, such as the expectation of the project owner and stakeholders, triple constraints of the project (cost, time, quality), and company's mission, vision, and objectives. Traditional decision-making methods for measuring the project success are usually based on subjective opinions of panel experts, resulting in irrational and inappropriate decisions. Therefore, this paper introduces a multi-attribute decision analysis method (MADAM) for weighting project success criteria by using fuzzy Analytical Hierarchy Process approach. It is found that this method is useful when dealing with imprecise and uncertain human judgments in evaluating project success criteria. Moreover, this research also suggests that although cost, time, and quality are three project success criteria projects, the satisfaction of project owner and acceptance of project stakeholders with the completed project criteria is the most important criteria for project success evaluation in Vietnam.

21 CFR 226.1 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Current good manufacturing practice. 226.1 Section...) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR TYPE A MEDICATED ARTICLES General Provisions § 226.1 Current good manufacturing practice. (a) The criteria in §§ 226.10 through 226.115, inclusive...

Criteria CSR

OpenAIRE

Vovk, V.; Zateyshikova, O.

2014-01-01

In the article the theoretical aspects regarding criteria for assessing CSR proposed by A. Carroll, including: economic, legal, ethical, philanthropic. Based on this, it is proposed to characterize these criteria with respect to the interested parties (stakeholders), including: investors, shareholders suppliers, customers, employees, society and the state. This will make a qualitative assessment of the presence and depth using social responsibility in the company, as well as determine the ext...

Pre-anthesis high-temperature acclimation alleviates damage to the flag leaf caused by post-anthesis heat stress in wheat

DEFF Research Database (Denmark)

Wang, Xiao; Cai, Jian; Jian, Dong

2011-01-01

and enhanced cell membrane peroxidation, as exemplified by increased O2-• production rate and reduction in activities of antioxiditave enzymes. However, under post-anthesis heat stress, plants with pre-anthesis hightemperature acclimation (HH)showedmuchhigher photosynthetic rates than those without pre...... all up-regulated under HH, whereas a gene encoding a major chlorophyll a/b-binding protein (Cab) was up-regulated by post-anthesis heat stress at 10 DAA, but was down-regulated at 13 DAA. The changes in the expression levels of the HH plants were more pronounced than those for the CH. Collectively......, the results indicated that pre-anthesis high-temperature acclimation could effectively alleviate the photosynthetic and oxidative damage caused by post-anthesis heat stress in wheat flag leaves, which was partially attributable to modifications in the expression of the photosythesis-responsive and antioxidant...

Controlling criteria for radiation exposure of astronauts and space workers

International Nuclear Information System (INIS)

Katoh, Kazuaki

1989-01-01

Space workers likely to suffer from radiation exposure in the outer space are currently limited to the U.S. and Soviet Union, and only a small amount of data and information is available concerning the techniques and criteria for control of radiation exposure in this field. Criteria used in the Soviet Union are described first. The criteria (TRS-75), called the Radiation Safety Criteria for Space Navigation, are tentative ones set up in 1975. They are based on risk assessment. The standard radiation levels are established based on unit flight time: 50rem for 1 month, 80rem for 3 months, 110rem for 6 months and 150rem for 12 months. These are largely different from the emergency exposure limit of 100mSv (10rem) specified in a Japanese law, and the standard annual exposure value of 50mSv (5rem) for workers in nuclear power plants at normal times. For the U.S., J.A. Angelo, Jr., presented a paper titled 'Radiation Protection Issues and Techniques concerning Extended Manned Space Missions' at an IAEA meeting held in 1988. Though the criteria shown in the paper are not formal ones at the national level, similar criteria are expected to be adopted by the nation in the near future. The exposure limits recommended in the paper include a depth dose of 1-4Sv for the whole life span of a worker. (Nogami, K.)

Technical evaluation of draft ANSI Standard N13.30, ''performance criteria for radiobioassay''

International Nuclear Information System (INIS)

MacLellan, J.A.; Traub, R.J.

1986-03-01

The Pacific Northwest Laboratory (PNL) is conducting a research program to evaluate the appropriateness of criteria in the ANSI draft Standard N13.30, ''Performance Criteria for Radiobioassay.'' The evaluation has progressed parallel with the preparation of the Standard by evaluating the performance of existing bioassay laboratories against the criteria specified. Recommendations for revision of the Standard and implementation of a testing/accreditation program have been formulated based on study results. The current performance testing program includes both in-vivo counting and in-vitro sample measurements. Test criteria specified in the Standard include relative bias, relative precision, and acceptable minimum detectable activity (AMDA). Results to date have indicated that the acceptance criteria in the Standard are appropriate for the existing state of the industry and are achievable by a majority of the participating laboratories. Specific conclusions are that the AMDA criteria are most difficult for the laboratories to achieve; the relative bias criterion is second in difficulty, and the precision criterion presents no problem for the laboratories; most of the participating laboratories can meet the Standard; and failure rates may decrease as the laboratories become more knowledgeable of the performance criteria. 3 refs., 11 figs., 6 tabs

Green Supplier Selection Criteria

DEFF Research Database (Denmark)

Nielsen, Izabela Ewa; Banaeian, Narges; Golinska, Paulina

2014-01-01

Green supplier selection (GSS) criteria arise from an organization inclination to respond to any existing trends in environmental issues related to business management and processes, so GSS is integrating environmental thinking into conventional supplier selection. This research is designed...... to determine prevalent general and environmental supplier selection criteria and develop a framework which can help decision makers to determine and prioritize suitable green supplier selection criteria (general and environmental). In this research we considered several parameters (evaluation objectives......) to establish suitable criteria for GSS such as their production type, requirements, policy and objectives instead of applying common criteria. At first a comprehensive and deep review on prevalent and green supplier selection literatures performed. Then several evaluation objectives defined to assess the green...

RADIATION ACCESS ZONE AND VENTILATION CONFINEMENT ZONE CRITERIA FOR THE MGR SURFACE FACILITIES

International Nuclear Information System (INIS)

D. A. Padula

2000-01-01

The objectives of this technical report are to: (1) Establish the criteria for Radiation Access Zone (RAZ) designation. (2) Establish the criteria for the Ventilation Confinement Zone (VCZ) designation. The scope will be to formulate the RAZ and VCZ zoning designation for the Monitored Geologic Repository (MGR) surface facilities and to apply the zoning designations to the current Waste Handling Building (WHB), Waste Treatment Building (WTB), and Carrier Preparation Building (CPB) configurations

Multi-Criteria Analysis for Solar Farm Location Suitability

Science.gov (United States)

Mierzwiak, Michal; Calka, Beata

2017-12-01

Currently the number of solar farms, as a type of renewable sources of energy, is growing rapidly. Photovoltaic power stations have many advantages, which is an incentive for their building and development. Solar energy is readily available and inexhaustible, and its production is environmentally friendly. In the present study multiple environmental and economic criteria were taken into account to select a potential photovoltaic farm location, with particular emphasis on: protected areas, land cover, solar radiation, slope angle, proximity to roads, built-up areas, and power lines. Advanced data analysis were used because of the multiplicity of criteria and their diverse influence on the choice of a potential location. They included the spatial analysis, the Weighted Linear Combination Technique (WLC), and the Analytic Hierarchy Process (AHP) as a decisionmaking method. The analysis was divided into two stages. In the first one, the areas where the location of solar farms was not possible were excluded. In the second one, the best locations meeting all environmental and economic criteria were selected. The research was conducted for the Legionowo District, using data from national surveying and mapping resources such as: BDOT10k (Database of Topographic Objects), NMT (Numerical Terrain Model), and lands and buildings register. Finally, several areas meeting the criteria were chosen. The research deals with solar farms with up to 40 kW power. The results of the study are presented as thematic maps. The advantage of the method is its versatility. It can be used not only for any area, but with little modification of the criteria, it can also be applied to choose a location for wind farms.

Flag brands as factor and results of a country identity and image: Polish experiences

Directory of Open Access Journals (Sweden)

Anna Maria Nikodemska-Wolowik

2006-12-01

Full Text Available This article discusses the issue of creating regional and country brands by enterprises and of establishing a national brand. The three mentioned flag brand categories have been described in detail and the relations between them have been indicated. The article also makes an attempt at analyzing the factors that form part of the brand identity focusing primarily on the consumer product brands. The identity and image concepts are presented also in a broader perspective as certain attributes that characterize the enterprise itself. The presented considerations refer mainly to Polish companies, but some examples of enterprises from highly developed countries, especially from the European Union, have also been added in order to provide this paper with more practical dimensions. Specific brands offered by national enterprises that may be called country and regional brands have been proposed. Some transformations of the market environment which imply branding activities of the companies have been identified, especially the antiglobalist movement which becomes more and more powerful and its activities directed against big concerns and omnipresent mass brands. Moreover, the consumer ethnocentrism and regional trends opposed to the globalization have been emphasized. Also the important rote of family businesses in developing flag brands has been made evident. The family companies may contribute to maintaining and reinforcing the Polish identity.El presente trabajo se ocupa de los aspectos referentes a la creación de marcas regionales y locales así como del establecimiento de una marca nacional. Las tres categorías de marcas de bandera se han caracterizado detalladamente y se indican las relaciones que existen entre ellas. También se intenta analizar los factores que forman parte de la identidad de marca, con especial atención a las marcas de productos de consumo. Se presentan los conceptos de identidad e imagen desde una perspectiva más amplia como

Combining the IADPSG criteria with the WHO diagnostic criteria for ...

African Journals Online (AJOL)

The International Association of Diabetes in Pregnancy Study Group (IADPSG) and World Health ... Macrosomia or at least one adverse outcome were more likely in GDM patients who ... criteria for GDM in the ADA's more recent position statement.[18] .... at risk for postpartum type 2 DM;[27] the IADPSG criteria on the other ...

The effect of soll water conditions on carbon isotope discrimination and minerals contents in spring-planted wheat

International Nuclear Information System (INIS)

Zhu Lin; Liang Zongsuo; Xu Xing; Li Shuhua

2008-01-01

Carbon isotope discrimination (triangle open 13 C) has been proposed as indirect selection criterion for transpiration efficiency and grain yield in wheat. However, because of high cost for triangle open 13 C analysis, attempts have been made to identify alternative screening criteria. Ash content (m a ) has been proposed as an alternative criterion for triangle open 13 C in wheat and barley. A pot experiment with three water treatments (45% ± 5% FC, 55% ± 5% FC and 75% ± 5%FC) was conducted and flag leaf triangle open 13 C (triangle openL a ), contents of ash, potassium (K), magnesium (Mg) and calcium (Ca) were measured to study the relationships between triangle open, mineral composition in spring planted bread wheat (Triticum aestivum L.). In the light of the results obtained in this research, the traits measured showed significant differences among the three water treatments. There were variations in triangle openL a between the genotypes derived from contrasting environments. The improved varieties or advanced lines bred in irrigated areas displayed higher triangle open 13 C values, while the improved and local varieties bred in rain-fed areas exhibited lower triangle open 13 C values Significant positive correlations were found between triangle open 13 C and m a in seedlings and second fully developed leaves at elongation stage and in flag leaves at anthesis stage in severe drought treatment (T 1 ) (r=0.790, P 13 C was negatively associated with potassium (K) content in flag leaves in T 2 (r=0.813, P 2 and T 3 (r=0.725, P 13 C and calcium (Ca) content in flag leaves in T 3 (r=0.708, P a is a possible alternative criterion of triangle open 13 C in vegetative organs especially in stressed environments. K, Mg and Ca contents in flag leaf under moderate water stress or feasible water conditions might be new predictive criteria of triangle openL a . (authors)

MANOVA, LDA, and FA criteria in clusters parameter estimation

Directory of Open Access Journals (Sweden)

Stan Lipovetsky

2015-12-01

Full Text Available Multivariate analysis of variance (MANOVA and linear discriminant analysis (LDA apply such well-known criteria as the Wilks’ lambda, Lawley–Hotelling trace, and Pillai’s trace test for checking quality of the solutions. The current paper suggests using these criteria for building objectives for finding clusters parameters because optimizing such objectives corresponds to the best distinguishing between the clusters. Relation to Joreskog’s classification for factor analysis (FA techniques is also considered. The problem can be reduced to the multinomial parameterization, and solution can be found in a nonlinear optimization procedure which yields the estimates for the cluster centers and sizes. This approach for clustering works with data compressed into covariance matrix so can be especially useful for big data.

Decision criteria in PSA applications

International Nuclear Information System (INIS)

Holmberg, J.E.; Pulkkinen, U.; Rosqvist, T.; Simola, K.

2001-11-01

Along with the adoption of risk informed decision making principles, the need for formal probabilistic decision rule or criteria has been risen. However, there are many practical and theoretical problems in the application of probabilistic criteria. One has to think what is the proper way to apply probabilistic rules together with deterministic ones and how the criteria are weighted with respect to each other. In this report, we approach the above questions from the decision theoretic point of view. We give a short review of the most well known probabilistic criteria, and discuss examples of their use. We present a decision analytic framework for evaluating the criteria, and we analyse how the different criteria behave under incompleteness or uncertainty of the PSA model. As the conclusion of our analysis we give recommendations on the application of the criteria in different decision situations. (au)

Guidelines and criteria for nuclear piping and support evaluation and design

International Nuclear Information System (INIS)

Rehn, D.L.; Stout, D.H. Jr.; Minichiello, J.C.

1993-05-01

The EPRI Research Project 2967-2 has set its fundamental goal to be the development of realistic guidelines and criteria for piping and pipe support design and evaluation. The focus is on items that are most critical to utilities and consists of a variety of tasks relating to piping and pipe support design. One objective of this report is to summarize the recommendations from the seven task reports of the first phase of the project and to provide examples of how to use those recommendations. Criteria and methods for evaluating both short and long term system operation are addressed. Benefits gained from applying the recommendations to actual systems are discussed. The report also reviews other work currently being done within the nuclear industry and assesses the impact of that work on the recommended criteria/methods of this project. The second objective of the report is to discuss possible changes needed in the governing codes or licensing commitments in order to implement the recommendations. Finally, the report describes further research which can be done to advance the criteria presented and answer questions concerning applicability of the proposed criteria to designs not tested/investigated. The basic conclusion reached in the project is that many of the criteria/methods used today in piping analysis/design are overly conservative. The report's conclusion is supported by extensive literature searches, tests, and analyses. The report presents a robust source of reference to utilities which wish to implement changes in criteria and methods. Most of the criteria and methodologies described in the seven task reports and summarized in the following sections will require some effort in licensing or Code changes

Potential Impact of DSM-5 Criteria on Autism Spectrum Disorder Prevalence Estimates

Science.gov (United States)

Maenner, Matthew J.; Rice, Catherine E.; Arneson, Carrie L.; Cunniff, Christopher; Schieve, Laura A.; Carpenter, Laura A.; Van Naarden Braun, Kim; Kirby, Russell S.; Bakian, Amanda V.; Durkin, Maureen S.

2014-01-01

IMPORTANCE The DSM-5 contains revised diagnostic criteria for autism spectrum disorder (ASD) from the DSM-IV-TR. Potential impacts of the new criteria on ASD prevalence are unclear. OBJECTIVE To assess potential effects of the DSM-5 ASD criteria on ASD prevalence estimation by retrospectively applying the new criteria to population-based surveillance data collected for previous ASD prevalence estimation. DESIGN, SETTING, AND PARTICIPANTS Cross-sectional, population-based ASD surveillance based on clinician review of coded behaviors documented in children’s medical and educational evaluations from 14 geographically defined areas in the United States participating in the Autism and Developmental Disabilities Monitoring (ADDM) Network in 2006 and 2008. This study included 8-year-old children living in ADDM Network study areas in 2006 or 2008, including 644 883 children under surveillance, of whom 6577 met surveillance ASD case status based on the DSM-IV-TR. MAIN OUTCOMES AND MEASURES Proportion of children meeting ADDM Network ASD criteria based on the DSM-IV-TR who also met DSM-5 criteria; overall prevalence of ASD using DSM-5 criteria. RESULTS Among the 6577 children classified by the ADDM Network as having ASD based on the DSM-IV-TR, 5339 (81.2%) met DSM-5 ASD criteria. This percentage was similar for boys and girls but higher for those with than without intellectual disability (86.6% and 72.5%, respectively; P DSM-5 ASD criteria but not current ADDM Network ASD case status. Based on these findings, ASD prevalence per 1000 for 2008 would have been 10.0 (95% CI, 9.6–10.3) using DSM-5 criteria compared with the reported prevalence based on DSM-IV-TR criteria of 11.3 (95% CI, 11.0–11.7). CONCLUSIONS AND RELEVANCE Autism spectrum disorder prevalence estimates will likely be lower under DSM-5 than under DSM-IV-TR diagnostic criteria, although this effect could be tempered by future adaptation of diagnostic practices and documentation of behaviors to fit the new

Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders.

Science.gov (United States)

Peck, C C; Goulet, J-P; Lobbezoo, F; Schiffman, E L; Alstergren, P; Anderson, G C; de Leeuw, R; Jensen, R; Michelotti, A; Ohrbach, R; Petersson, A; List, T

2014-01-01

There is a need to expand the current temporomandibular disorders' (TMDs) classification to include less common but clinically important disorders. The immediate aim was to develop a consensus-based classification system and associated diagnostic criteria that have clinical and research utility for less common TMDs. The long-term aim was to establish a foundation, vis-à-vis this classification system, that will stimulate data collection, validity testing and further criteria refinement. A working group [members of the International RDC/TMD Consortium Network of the International Association for Dental Research (IADR), members of the Orofacial Pain Special Interest Group (SIG) of the International Association for the Study of Pain (IASP), and members from other professional societies] reviewed disorders for inclusion based on clinical significance, the availability of plausible diagnostic criteria and the ability to operationalise and study the criteria. The disorders were derived from the literature when possible and based on expert opinion as necessary. The expanded TMDs taxonomy was presented for feedback at international meetings. Of 56 disorders considered, 37 were included in the expanded taxonomy and were placed into the following four categories: temporomandibular joint disorders, masticatory muscle disorders, headache disorders and disorders affecting associated structures. Those excluded were extremely uncommon, lacking operationalised diagnostic criteria, not clearly related to TMDs, or not sufficiently distinct from disorders already included within the taxonomy. The expanded TMDs taxonomy offers an integrated approach to clinical diagnosis and provides a framework for further research to operationalise and test the proposed taxonomy and diagnostic criteria. © 2014 John Wiley & Sons Ltd.

A critical review of “Internet addiction” criteria with suggestions for the future

Science.gov (United States)

VAN ROOIJ, ANTONIUS J.; PRAUSE, NICOLE

2014-01-01

Aims: In the last 5 years a deluge of articles on the topic of Internet addiction (IA) has proposed many candidate symptoms as evidence of this proposed disease. We critically reviewed the current approach to the measurement and identification of this new excessive behavior syndrome. Methods: Three popular models of IA were discussed: Griffith’s components model; Young’s Internet Addiction Test (IAT); and the criteria by Tao et al. (2010). We selected these models because they are widely cited and propose specific criteria for IA disorder. Our approach is not meant to provide an exhaustive review, but to discuss and critique the most salient trends in the field. Results: The models of Internet addiction share some criteria, including feeling a loss of control over Internet use; ensuing psychological, social, or professional conflict or problems; and preoccupation when not using the Internet. Other criteria inconsistently mentioned include: mood management, tolerance, withdrawal, and craving/anticipation. The models studied here share the assumption that the Internet can produce a qualitative shift to a diseased state in humans. Conclusions: We critically discussed the above criteria and concluded that the evidence base is currently not strong enough to provide support for an Internet addiction disorder. Future research areas are suggested: (1) Focusing on common impaired dimensions, (2) exploring neuroimaging as a model building tool, and (3) identifying shifts in the rewarding aspects of Internet use. Given the lack of consensus on the subject of Internet addiction, a focus on problem behaviors appears warranted. PMID:25592305

The Atomic Energy Control Board criteria for identification and evaluation of fire hazards in nuclear power stations

International Nuclear Information System (INIS)

Morrison, Luke

1986-03-01

This report presents criteria for the identification and evaluation of fire hazards in nuclear power stations. The report presents criteria that are consistent with the existing regulatory approach in Canada, and outlines engineering tools and analytical techniques currently available to deterministically analyse fire. The criteria presented cover the topics which should be included in a fire hazard analysis and provide details of each topic so that the accuracy of an analysis may be evaluated

Quantitative trait loci (QTL) analysis of flag leaf senescence in wheat ...

African Journals Online (AJOL)

PAVILION DV6

2012-07-10

Triticum aestivum L.) production is adversely ... stressed environments, have been identified, using ... others) have been studied for many different criteria or ..... analysis of post-flowering drought tolerance and components of grain.

A windows based automated quality control system for the ICP-AES analysis of Waste Isolation Pilot Plant (WIPP) brines

International Nuclear Information System (INIS)

Gerth, D.J.

1996-01-01

High sample volume analytical laboratories typically require automation of tasks to maximize efficiency and productivity. Typical approaches target instrument operation and data reporting (LIMS), but frequently ignore the data evaluation and run time QC aspects. Automation of these steps can save up to 50% of the time it takes to analyze, evaluate, and report data from a typical ICP-AES run. The program developed in this project addresses this need by performing a CLP-style evaluation of the run time QC data included in an instrument run. Written in Microcraft Visual Basic 3.0, it makes use of a Microsoft Access database to store method parameters and QC sample results for control charting. In operation, the analyst enters method background data (e.g., control samples types and acceptance criteria for each analyte), which is then stored in the method database. Once the method parameters are entered, instrument data files may be imported for review. Upon import, the run is automatically checked against desired QC criteria, QC sample data are added to the database, and failing samples flagged appropriately. Analytes passing all QC checks are flagged for upload to the laboratory LIMS. The analyst may then review the run sample by sample, and, if desired, override the computer upload flag. An exception report may be generated detailing samples that require reanalysis

2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative

Science.gov (United States)

Neogi, Tuhina; Jansen, Tim L Th A; Dalbeth, Nicola; Fransen, Jaap; Schumacher, H Ralph; Berendsen, Dianne; Brown, Melanie; Choi, Hyon; Edwards, N Lawrence; Janssens, Hein J E M; Lioté, Frédéric; Naden, Raymond P; Nuki, George; Ogdie, Alexis; Perez-Ruiz, Fernando; Saag, Kenneth; Singh, Jasvinder A; Sundy, John S; Tausche, Anne-Kathrin; Vaquez-Mellado, Janitzia; Yarows, Steven A; Taylor, William J

2015-01-01

Objective Existing criteria for the classification of gout have suboptimal sensitivity and/or specificity, and were developed at a time when advanced imaging was not available. The current effort was undertaken to develop new classification criteria for gout. Methods An international group of investigators, supported by the American College of Rheumatology and the European League Against Rheumatism, conducted a systematic review of the literature on advanced imaging of gout, a diagnostic study in which the presence of monosodium urate monohydrate (MSU) crystals in synovial fluid or tophus was the gold standard, a ranking exercise of paper patient cases, and a multi-criterion decision analysis exercise. These data formed the basis for developing the classification criteria, which were tested in an independent data set. Results The entry criterion for the new classification criteria requires the occurrence of at least one episode of peripheral joint or bursal swelling, pain, or tenderness. The presence of MSU crystals in a symptomatic joint/bursa (ie, synovial fluid) or in a tophus is a sufficient criterion for classification of the subject as having gout, and does not require further scoring. The domains of the new classification criteria include clinical (pattern of joint/bursa involvement, characteristics and time course of symptomatic episodes), laboratory (serum urate, MSU-negative synovial fluid aspirate), and imaging (double-contour sign on ultrasound or urate on dual-energy CT, radiographic gout-related erosion). The sensitivity and specificity of the criteria are high (92% and 89%, respectively). Conclusions The new classification criteria, developed using a data-driven and decision-analytic approach, have excellent performance characteristics and incorporate current state-of-the-art evidence regarding gout. PMID:26359487

The leak before break criteria, requirements and implications; El criterio de fuga antes de ruptura, requerimientos e implicaciones

Energy Technology Data Exchange (ETDEWEB)

Martinez M, E

1992-05-15

Inside this work a general balance is made on the Leak before break approach (LBB), like they are the history and licensing, those limitations, the acceptance criteria of the LBB, the current state of the regulatory development and the current state of it application in countries like E.U.A, Germany, Canada, Italy and France. Everything it with the purpose of evaluating the opportunities that offers the LBB criteria for it possible application in Mexico. (Author)

Criteria for Drug Reimbursement Decision-Making: An Emerging Public Health Challenge in Bulgaria

Directory of Open Access Journals (Sweden)

Georgi Iskrov

2016-02-01

Full Text Available Background: During times of fiscal austerity, means of reimbursement decision-making are of particular interest for public health theory and practice. Introduction of advanced health technologies, growing health expenditures and increased public scrutiny over drug reimbursement decisions have pushed governments to consider mechanisms that promote the use of effective health technologies, while constraining costs. Aims: The study’s aim was to explore the current rationale of the drug reimbursement decision-making framework in Bulgaria. Our pilot research focused on one particular component of this process – the criteria used – because of the critical role that criteria are known to have in setting budgets and priorities in the field of public health. The analysis pursued two objectives: to identify important criteria relevant to drug reimbursement decision-making and to unveil relationships between theory and practice. Study Design: Cross-sectional study. Methods: The study was realized through a closed-ended survey on reimbursement criteria among four major public health stakeholders – medical professionals, patients, health authorities, and industry. Empirical outcomes were then cross-compared with the theoretical framework, as defined by current Bulgarian public health legislation. Analysis outlined what is done and what needs to be done in the field of public health reimbursement decision-making. Results: Bulgarian public health stakeholders agreed on 15 criteria to form a tentative optimal framework for drug reimbursement decision-making. The most apparent gap between the empirically found preferences and the official legislation is the lack of consideration for the strength of evidence in reimbursement decisions. Conclusion: Bulgarian policy makers need to address specific gaps, such as formal consideration for strength of evidence, explicit role of efficiency criteria, and means to effectively empower patient and citizen

Discovery of C5-C17 poly- and perfluoroalkyl substances in water by in-line SPE-HPLC-Orbitrap with in-source fragmentation flagging.

Science.gov (United States)

Liu, Yanna; Pereira, Alberto Dos Santos; Martin, Jonathan W

2015-04-21

The presence of unknown organofluorine compounds in environmental samples has prompted the development of nontargeted analytical methods capable of detecting new perfluoroalkyl and polyfluoroalkyl substances (PFASs). By combining high volume injection with high performance liquid chromatography (HPLC) and ultrahigh resolution Orbitrap mass spectrometry, a sensitive (0.003-0.2 ng F/mL for model mass-labeled PFASs) untargeted workflow was developed for discovery and characterization of novel PFASs in water. In the first step, up to 5 mL of water is injected to in-line solid phase extraction, chromatographed by HPLC, and detected by electrospray ionization with mass spectral acquisition in parallel modes cycling back and forth: (i) full scan with ultrahigh resolving power (RP = 120,000, mass accuracy ≤3 ppm), and (ii) in-source fragmentation flagging scans designed to yield marker fragment ions including [C2F5](-) (m/z 118.992), [C3F7](-) (m/z 168.988), [SO4H](-) (m/z 96.959), and [Cl](-) (m/z 34.9). For flagged PFASs, plausible empirical formulas were generated from accurate masses, isotopic patterns, and fragment ions. In the second step, another injection is made to collect high resolution MS/MS spectra of suspect PFAS ions, allowing further confirmation of empirical formulas while also enabling preliminary structural characterization. The method was validated by applying it to an industrial wastewater, and 36 new PFASs were discovered. Of these, 26 were confidently assigned to 3 new PFAS classes that have not previously been reported in the environment: polyfluorinated sulfates (CnFn+3Hn-2SO4(-); n = 5, 7, 9, 11, 13, and 15), chlorine substituted perfluorocarboxylates (ClCnF2nCO2(-); n = 4-11), and hydro substituted perfluorocarboxylates (HCnF2nCO2(-); n = 5-16). Application of the technique to environmental water samples is now warranted.

Criteria procedure development for tender in construction design

Directory of Open Access Journals (Sweden)

Malykha Galina Gennad’evna

order". The article describes in detail the above evaluation criteria (sub-criteria and presents a new procedure of evaluation of competitive bids, which will allow combining its new components with those existing under the law and giving the actual result of their interaction with each other in determination of a winner, i.e. a more well-deserved candidate (a tenderer. Thus the requirements given above are met, the participants in order placement will be able to declare themselves as organizations that are highly skilled, fair and able to perform the high-quality design works, know how to perform work in due time and in strict compliance with the current regulations of the Russian Federation and are able not only to show a creative approach to solving the objectives, but also to create a project characterized by both architectural and artistic aesthetics and its high technological effectiveness.

Coeliac disease diagnosis: espghan 1990 Criteria or need for a change? Results of a questionnaire

DEFF Research Database (Denmark)

Ribes-Koninckx, C; Mearin, Ml; Korponay-Szabó, Ir

2012-01-01

INTRODUCTION:: A revision of criteria for diagnosing celiac disease (CD) is currently being conducted by ESPGHAN. In parallel, we have performed a survey aimed to evaluate current practices for CD among pediatric gastroenterologists (PG) and to learn their views on the need for modification...

Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria.

Science.gov (United States)

Seymour, Christopher W; Coopersmith, Craig M; Deutschman, Clifford S; Gesten, Foster; Klompas, Michael; Levy, Mitchell; Martin, Gregory S; Osborn, Tiffany M; Rhee, Chanu; Warren, David K; Watson, R Scott; Angus, Derek C

2016-03-01

The current definition of sepsis is life-threatening, acute organ dysfunction secondary to a dysregulated host response to infection. Criteria to operationalize this definition can be judged by six domains of usefulness (reliability, content, construct and criterion validity, measurement burden, and timeliness). The relative importance of these six domains depends on the intended purpose for the criteria (clinical care, basic and clinical research, surveillance, or quality improvement [QI] and audit). For example, criteria for clinical care should have high content and construct validity, timeliness, and low measurement burden to facilitate prompt care. Criteria for surveillance or QI/audit place greater emphasis on reliability across individuals and sites and lower emphasis on timeliness. Criteria for clinical trials require timeliness to ensure prompt enrollment and reasonable reliability but can tolerate high measurement burden. Basic research also tolerates high measurement burden and may not need stability over time. In an illustrative case study, we compared examples of criteria designed for clinical care, surveillance and QI/audit among 396,241 patients admitted to 12 academic and community hospitals in an integrated health system. Case rates differed four-fold and mortality three-fold. Predictably, clinical care criteria, which emphasized timeliness and low burden and therefore used vital signs and routine laboratory tests, had the greater case identification with lowest mortality. QI/audit criteria, which emphasized reliability and criterion validity, used discharge information and had the lowest case identification with highest mortality. Using this framework to identify the purpose and apply domains of usefulness can help with the evaluation of existing sepsis diagnostic criteria and provide a roadmap for future work.

Fuel safety criteria in NEA member countries - Compilation of responses received from member countries

International Nuclear Information System (INIS)

2003-03-01

In 2001 the Committee on the Safety of Nuclear Installations (CSNI) issued a report on Fuel Safety Criteria Technical Review. The objective was to review the present fuel safety criteria and judge to which extent they are affected by the 'new' design elements, such as different cladding materials, higher burnup, the use of MOX fuels, etc. The report stated that the current framework of fuel safety criteria remains generally applicable, being largely unaffected by the 'new' or modern design elements. The levels (numbers) in the individual safety criteria may, however, change in accordance with the particular fuel and core design features. Some of these levels have already been - or are continuously being - adjusted. The level adjustments of several other criteria (RIA, LOCA) also appears to be needed, on the basis of experimental data and the analysis thereof. As a follow-up, among its first tasks, the CSNI Special Expert Group on Fuel Safety Margins (SEG FSM) initiated the collection of information on the present fuel safety criteria used in NEA member states with the objective to solicit national practices in the use of fuel safety criteria, in particular to get information on their specific national levels/values, including their recent adjustments, and to identify the differences and commonalties between the different countries. Two sources of information were used to produce this report: a compilation of responses to a questionnaire prepared for the June 2000 CNRA meeting, and individual responses from the SEGFSM members to the new revised questionnaire issued by the task Force preparing this report. In accordance with the latter, the fuel safety criteria discussed in this report were divided into three categories: (A) safety criteria - criteria imposed by the regulator; (B) operational criteria - specific to the fuel design and provided by the fuel vendor as part of the licensing basis; (C) design criteria - limits employed by vendors and/or utilities for fuel

Continuity between DSM-5 Categorical Criteria and Traits Criteria for Borderline Personality Disorder.

Science.gov (United States)

Bach, Bo; Sellbom, Martin

2016-08-01

Borderline personality disorder (BPD) includes a heterogeneous constellation of symptoms operationalized with 9 categorical criteria. As the field of personality disorder (PD) research moves to emphasize dimensional traits in its operationalization, it is important to delineate continuity between the 9 DSM-IV/Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) categorical criteria for BPD and the trait dimensions in DSM-5 Section III. To date, no study has attempted such validation. We examined the associations between the 9 categorical DSM-IV/DSM-5 criteria for BPD and the trait dimensions of the alternative DSM-5 model for PDs in consecutively recruited psychiatric outpatients (N = 142; 68% female; age: mean 29.02, SD 8.38). This was investigated by means of bivariate correlations, followed by multiple logistic regression analysis. The categorical BPD criteria were associated with conceptually related DSM-5 Section III traits (P > 0.001), except for the criterion of chronic feelings of emptiness. Consistent with the proposed traits criteria for BPD in DSM-5 Section III, we found Emotional lability, Anxiousness, Separation insecurity, Depressivity, Impulsivity, Risk taking, and Hostility to capture conceptually coherent BPD categorical criteria, while Suspiciousness was also strongly associated with BPD criteria. At the domain level, this applied to Negative affectivity, Disinhibition, and Psychoticism. Notably, Emotional lability, Impulsivity, and Suspiciousness emerged as unique predictors of BPD (P > 0.05). In addition to the proposed BPD traits criteria, Suspiciousness and features of Psychoticism also augment BPD features. Provided that these findings are replicated in forthcoming research, a modified traits operationalization of BPD is warranted. © The Author(s) 2016.

Multi-criteria decision-making on assessment of proposed tidal barrage schemes in terms of environmental impacts.

Science.gov (United States)

Wu, Yunna; Xu, Chuanbo; Ke, Yiming; Chen, Kaifeng; Xu, Hu

2017-12-15

For tidal range power plants to be sustainable, the environmental impacts caused by the implement of various tidal barrage schemes must be assessed before construction. However, several problems exist in the current researches: firstly, evaluation criteria of the tidal barrage schemes environmental impact assessment (EIA) are not adequate; secondly, uncertainty of criteria information fails to be processed properly; thirdly, correlation among criteria is unreasonably measured. Hence the contributions of this paper are as follows: firstly, an evaluation criteria system is established from three dimensions of hydrodynamic, biological and morphological aspects. Secondly, cloud model is applied to describe the uncertainty of criteria information. Thirdly, Choquet integral with respect to λ-fuzzy measure is introduced to measure the correlation among criteria. On the above bases, a multi-criteria decision-making decision framework for tidal barrage scheme EIA is established to select the optimal scheme. Finally, a case study demonstrates the effectiveness of the proposed framework. Copyright © 2017 Elsevier Ltd. All rights reserved.

Technical guidance for siting criteria development

International Nuclear Information System (INIS)

Aldrich, D.C.; Sprung, J.L.; Alpert, D.J.

1982-12-01

Technical guidance to support the formulation and comparison of possible siting criteria for nuclear power plants has been developed in four areas: (1) consequences of hypothetical severe nuclear-power-plant accidents, (2) characteristics of population distributions about current reactor sites, (3) site availability within the continental United States, and (4) socioeconomic impacts of reactor siting. The impact on consequences of source-term magnitude, meteorology, population distribution, and emergency response have been analyzed. Population distributions about current sites were analyzed to identify statistical characteristics, time trends, and regional differences. A site-availability data bank was constructed for the continential United States. The data bank contains information about population densities, seismicity, topography, water availability, and land-use restrictions. Finally, the socioeconomic impacts of rural-industrialization projects, energy boomtowns, and nuclear power plants were examined to determine their nature, magnitude, and dependence on site demography and remoteness

Technical guidance for siting criteria development

Energy Technology Data Exchange (ETDEWEB)

Aldrich, D.C.; Sprung, J.L.; Alpert, D.J.; Diegert, K.; Ostmeyer, R.M.; Ritchie, L.T.; Strip, D.R.; Johnson, J.D.; Hansen, K.; Robinson, J.

1982-12-01

Technical guidance to support the formulation and comparison of possible siting criteria for nuclear power plants has been developed in four areas: (1) consequences of hypothetical severe nuclear-power-plant accidents, (2) characteristics of population distributions about current reactor sites, (3) site availability within the continental United States, and (4) socioeconomic impacts of reactor siting. The impact on consequences of source-term magnitude, meteorology, population distribution, and emergency response have been analyzed. Population distributions about current sites were analyzed to identify statistical characteristics, time trends, and regional differences. A site-availability data bank was constructed for the continential United States. The data bank contains information about population densities, seismicity, topography, water availability, and land-use restrictions. Finally, the socioeconomic impacts of rural-industrialization projects, energy boomtowns, and nuclear power plants were examined to determine their nature, magnitude, and dependence on site demography and remoteness.

Selection criteria for building performance simulation tools : contrasting architects' and engineers' needs

NARCIS (Netherlands)

Attia, S.G.; Hensen, J.L.M.; Beltran, L.; De Herde, A.

2012-01-01

This article summarises a study undertaken to reveal potential challenges and opportunities for using building performance simulation (BPS) tools. The article reviews current trends in building simulation and outlines major criteria for BPS tool selection and evaluation based on analysing users'

Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations (II): thrombocytopenia and skin manifestations.

Science.gov (United States)

Cervera, R; Tektonidou, M G; Espinosa, G; Cabral, A R; González, E B; Erkan, D; Vadya, S; Adrogué, H E; Solomon, M; Zandman-Goddard, G; Shoenfeld, Y

2011-02-01

The objectives of the 'Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations' were to assess the clinical utility of the international consensus statement on classification criteria and treatment guidelines for the catastrophic APS, to identify and grade the studies that analyze the relationship between the antiphospholipid antibodies and the non-criteria APS manifestations, and to present the current evidence regarding the accuracy of these non-criteria APS manifestations for the detection of patients with APS. This article summarizes the studies analyzed on thrombocytopenia and skin manifestations, and presents the recommendations elaborated by the Task Force after this analysis.

Rating of environmental criteria

Energy Technology Data Exchange (ETDEWEB)

Glueck, K; Krasser, G

1980-01-01

After a general theoretical discussion on the question of rating within a framework of cost-benefit studies, first trials as to the quantification and standardisation of twelve selected environmental criteria by means of an indicator system are worked out and compiled. The selection includes the criteria exhaust gas, dust, micro climate, water pollution, water regime, land requirement, vibrations, traffic noise, landscape scene, urban scene, effect of separation and safety risks. An insight is given of the rating practice using an evaluation of the available literature, of a household interview and of an interview of experts. The interviewing of 156 experts as to their rating conception of ten criteria in the second round has provided contributions to the general problem of the evaluation estimate based on multi criteria analysis as well as differentiation of the twelve or ten environmental criteria. The following criteria ratings given by the experts and which are averaged and smoothed are: traffic noise 20,0% +- 8,5; air pollution 15,0% +- 7,0; safety risk 13,0% +- 7,0; soil and water pollution 8,5% +- 5,0; landscape scene 8,0% +- 4,5; urban scene 8,0% +- 4,5; water regime 6,5% +- 3,5 and vibrations 4,5% +- 2,5.

MCO combustible gas management leak test acceptance criteria; TOPICAL

International Nuclear Information System (INIS)

SHERRELL, D.L.

1999-01-01

Existing leak test acceptance criteria for mechanically sealed and weld sealed multi-canister overpacks (MCO) were evaluated to ensure that MCOs can be handled and stored in stagnant air without compromising the Spent Nuclear Fuel Project's overall strategy to prevent accumulation of combustible gas mixtures within MCO's or within their surroundings. The document concludes that the integrated leak test acceptance criteria for mechanically sealed and weld sealed MCOs (1 x 10(sup -5) std cc/sec and 1 x 10(sup -7) std cc/sec, respectively) are adequate to meet all current and foreseeable needs of the project, including capability to demonstrate compliance with the NFPA 60 Paragraph 3-3 requirement to maintain hydrogen concentrations[within the air atmosphere CSB tubes] t or below 1 vol% (i.e., at or below 25% of the LFL)

Design loads, loading combinations and structural acceptance criteria for BWR containments in the United States

International Nuclear Information System (INIS)

Edwards, N.W.

1979-01-01

The definition of loads, loading combinations, and structural acceptance criteria used for the design and evaluation of BWR containments in the Unites States has become much more comprehensive over the past decade. The Mark I pressure suppression containment vessels were designed for a static design pressure, a design temperature, dead load and static equivalent earthquake. The current Mark III containments are being designed to accommodate many more loads such as safety relief valve discharge loads, and suppression pool hydrodynamic loadings associated with the steam condensation phenomena as well as pressure and temperature transients for a range of pipe break sizes. Consistent with the more comprehensive definition of loads and loading combinations, the ASME Code presently establishes structural acceptance criteria with different margins of safety by the definition of Service Level Assignments A, B, C and D. Acting in a responsible manner, United States utilities are currently evaluating and modifying existing containment vessels to account for the more detailed load definition and structural acceptance criteria. (orig.)

Analysing and Comparing Encodability Criteria

Directory of Open Access Journals (Sweden)

Kirstin Peters

2015-08-01

Full Text Available Encodings or the proof of their absence are the main way to compare process calculi. To analyse the quality of encodings and to rule out trivial or meaningless encodings, they are augmented with quality criteria. There exists a bunch of different criteria and different variants of criteria in order to reason in different settings. This leads to incomparable results. Moreover it is not always clear whether the criteria used to obtain a result in a particular setting do indeed fit to this setting. We show how to formally reason about and compare encodability criteria by mapping them on requirements on a relation between source and target terms that is induced by the encoding function. In particular we analyse the common criteria full abstraction, operational correspondence, divergence reflection, success sensitiveness, and respect of barbs; e.g. we analyse the exact nature of the simulation relation (coupled simulation versus bisimulation that is induced by different variants of operational correspondence. This way we reduce the problem of analysing or comparing encodability criteria to the better understood problem of comparing relations on processes.

Identification and evaluation of influential criteria for the selection of an environmental shipping carrier using DEMATEL

DEFF Research Database (Denmark)

Jia, Peng; Govindan, Kannan; Kannan, Devika

2015-01-01

The current environmental pollution is a major factor in economic development and vehicle pollution is ranked next to industrial emissions in total emissions worldwide. This study focuses on the selection of a suitable shipping carrier from an economic and environmental perspective. In practice......, there are many criteria's available to select a suitable shipping container. But, shipping container companies are struggling to identify the most influential criteria to select a shipping container as it requires in-depth analysis. So, the objective of this paper is to analyse the criteria and identify the most...... influential criteria from an environmental practices perspective. In this study, seventeen factors are identified from literature aimed at locating the most influential criteria to select a suitable shipping carrier using the decision making trial and evaluation laboratory (DEMATEL). This procedure helps...

Diagnostic Criteria for Pediatric MS

Directory of Open Access Journals (Sweden)

J Gordon Millichap

2013-06-01

Full Text Available Investigators at Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children’s Hospital of Chicago review the diagnostic criteria for pediatric multiple sclerosis, the differential diagnosis, the 2010 McDonald criteria, and Callen criteria.

Central nervous system infectious diseases mimicking multiple sclerosis: recognizing distinguishable features using MRI

Directory of Open Access Journals (Sweden)

Antonio Jose da Rocha

2013-09-01

Full Text Available The current diagnostic criteria for multiple sclerosis (MS confirm the relevant role of magnetic resonance imaging (MRI, supporting the possibility of characterizing the dissemination in space (DIS and the dissemination in time (DIT in a single scan. To maintain the specificity of these criteria, it is necessary to determine whether T2/FLAIR visible lesions and the gadolinium enhancement can be attributed to diseases that mimic MS. Several diseases are included in the MS differential diagnosis list, including diseases with exacerbation, remitting periods and numerous treatable infectious diseases, which can mimic the MRI features of MS. We discuss the most relevant imaging features in several infectious diseases that resemble MS and examine the primary spatial distributions of lesions and the gadolinium enhancement patterns related to MS. Recognizing imaging "red flags" can be useful for the proper diagnostic evaluation of suspected cases of MS, facilitating the correct differential diagnosis by assessing the combined clinical, laboratory and MR imaging information.

Regulatory analysis on criteria for the release of patients administered radioactive material. Final report

Energy Technology Data Exchange (ETDEWEB)

Schneider, S.; McGuire, S.A.

1997-02-01

This regulatory analysis was developed to respond to three petitions for rulemaking to amend 10 CFR parts 20 and 35 regarding release of patients administered radioactive material. The petitions requested revision of these regulations to remove the ambiguity that existed between the 1-millisievert (0.1-rem) total effective dose equivalent (TEDE) public dose limit in Part 20, adopted in 1991, and the activity-based release limit in 10 CFR 35.75 that, in some instances, would permit release of individuals in excess of the current public dose limit. Three alternatives for resolution of the petitions were evaluated. Under Alternative 1, NRC would amend its patient release criteria in 10 CFR 35.75 to match the annual public dose limit in Part 20 of 1 millisievert (0.1 rem) TEDE. Alternative 2 would maintain the status quo of using the activity-based release criteria currently found in 10 CFR 35.75. Under Alternative 3, the NRC would revise the release criteria in 10 CFR 35.75 to specify a dose limit of 5 millisieverts (0.5 rem) TEDE.

Regulatory analysis on criteria for the release of patients administered radioactive material. Final report

International Nuclear Information System (INIS)

Schneider, S.; McGuire, S.A.

1997-02-01

This regulatory analysis was developed to respond to three petitions for rulemaking to amend 10 CFR parts 20 and 35 regarding release of patients administered radioactive material. The petitions requested revision of these regulations to remove the ambiguity that existed between the 1-millisievert (0.1-rem) total effective dose equivalent (TEDE) public dose limit in Part 20, adopted in 1991, and the activity-based release limit in 10 CFR 35.75 that, in some instances, would permit release of individuals in excess of the current public dose limit. Three alternatives for resolution of the petitions were evaluated. Under Alternative 1, NRC would amend its patient release criteria in 10 CFR 35.75 to match the annual public dose limit in Part 20 of 1 millisievert (0.1 rem) TEDE. Alternative 2 would maintain the status quo of using the activity-based release criteria currently found in 10 CFR 35.75. Under Alternative 3, the NRC would revise the release criteria in 10 CFR 35.75 to specify a dose limit of 5 millisieverts (0.5 rem) TEDE

Proposed Diagnostic Criteria for Smartphone Addiction.

Science.gov (United States)

Lin, Yu-Hsuan; Chiang, Chih-Lin; Lin, Po-Hsien; Chang, Li-Ren; Ko, Chih-Hung; Lee, Yang-Han; Lin, Sheng-Hsuan

2016-01-01

Global smartphone penetration has led to unprecedented addictive behaviors. The aims of this study are to develop diagnostic criteria of smartphone addiction and to examine the discriminative ability and the validity of the diagnostic criteria. We developed twelve candidate criteria for characteristic symptoms of smartphone addiction and four criteria for functional impairment caused by excessive smartphone use. The participants consisted of 281 college students. Each participant was systematically assessed for smartphone-using behaviors by psychiatrist's structured diagnostic interview. The sensitivity, specificity, and diagnostic accuracy of the candidate symptom criteria were analyzed with reference to the psychiatrists' clinical global impression. The optimal model selection with its cutoff point of the diagnostic criteria differentiating the smartphone addicted subjects from non-addicted subjects was then determined by the best diagnostic accuracy. Six symptom criteria model with optimal cutoff point were determined based on the maximal diagnostic accuracy. The proposed smartphone addiction diagnostic criteria consisted of (1) six symptom criteria, (2) four functional impairment criteria and (3) exclusion criteria. Setting three symptom criteria as the cutoff point resulted in the highest diagnostic accuracy (84.3%), while the sensitivity and specificity were 79.4% and 87.5%, respectively. We suggested determining the functional impairment by two or more of the four domains considering the high accessibility and penetration of smartphone use. The diagnostic criteria of smartphone addiction demonstrated the core symptoms "impaired control" paralleled with substance related and addictive disorders. The functional impairment involved multiple domains provide a strict standard for clinical assessment.

Proposed Diagnostic Criteria for Smartphone Addiction.

Directory of Open Access Journals (Sweden)

Yu-Hsuan Lin

Full Text Available Global smartphone penetration has led to unprecedented addictive behaviors. The aims of this study are to develop diagnostic criteria of smartphone addiction and to examine the discriminative ability and the validity of the diagnostic criteria.We developed twelve candidate criteria for characteristic symptoms of smartphone addiction and four criteria for functional impairment caused by excessive smartphone use. The participants consisted of 281 college students. Each participant was systematically assessed for smartphone-using behaviors by psychiatrist's structured diagnostic interview. The sensitivity, specificity, and diagnostic accuracy of the candidate symptom criteria were analyzed with reference to the psychiatrists' clinical global impression. The optimal model selection with its cutoff point of the diagnostic criteria differentiating the smartphone addicted subjects from non-addicted subjects was then determined by the best diagnostic accuracy.Six symptom criteria model with optimal cutoff point were determined based on the maximal diagnostic accuracy. The proposed smartphone addiction diagnostic criteria consisted of (1 six symptom criteria, (2 four functional impairment criteria and (3 exclusion criteria. Setting three symptom criteria as the cutoff point resulted in the highest diagnostic accuracy (84.3%, while the sensitivity and specificity were 79.4% and 87.5%, respectively. We suggested determining the functional impairment by two or more of the four domains considering the high accessibility and penetration of smartphone use.The diagnostic criteria of smartphone addiction demonstrated the core symptoms "impaired control" paralleled with substance related and addictive disorders. The functional impairment involved multiple domains provide a strict standard for clinical assessment.

21 CFR 129.1 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 129.1 Section... Current good manufacturing practice. The applicable criteria in part 110 of this chapter, as well as the..., methods, practices, and controls used in the processing, bottling, holding, and shipping of bottled...

Current Issues in the Diagnosis of Attention Deficit Hyperactivity Disorder, Oppositional Defiant Disorder, and Conduct Disorder

Science.gov (United States)

Frick, Paul J.; Nigg, Joel T.

2015-01-01

This review evaluates the diagnostic criteria for three of the most common disorders for which children and adolescents are referred for mental health treatment: attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD). Although research supports the validity and clinical utility of these disorders, several issues are highlighted that could enhance the current diagnostic criteria. For ADHD, defining the core features of the disorder and its fit with other disorders, enhancing the validity of the criteria through the lifespan, considering alternative ways to form subtypes of the disorder, and modifying the age-of-onset criterion are discussed relative to the current diagnostic criteria. For ODD, eliminating the exclusionary criteria of CD, recognizing important symptom domains within the disorder, and using the cross-situational pervasiveness of the disorder as an index of severity are highlighted as important issues for improving classification. Finally, for CD, enhancing the current subtypes related to age of onset and integrating callous-unemotional traits into the diagnostic criteria are identified as key issues for improving classification. PMID:22035245

Current issues in the diagnosis of attention deficit hyperactivity disorder, oppositional defiant disorder, and conduct disorder.

Science.gov (United States)

Frick, Paul J; Nigg, Joel T

2012-01-01

This review evaluates the diagnostic criteria for three of the most common disorders for which children and adolescents are referred for mental health treatment: attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD). Although research supports the validity and clinical utility of these disorders, several issues are highlighted that could enhance the current diagnostic criteria. For ADHD, defining the core features of the disorder and its fit with other disorders, enhancing the validity of the criteria through the lifespan, considering alternative ways to form subtypes of the disorder, and modifying the age-of-onset criterion are discussed relative to the current diagnostic criteria. For ODD, eliminating the exclusionary criteria of CD, recognizing important symptom domains within the disorder, and using the cross-situational pervasiveness of the disorder as an index of severity are highlighted as important issues for improving classification. Finally, for CD, enhancing the current subtypes related to age of onset and integrating callous-unemotional traits into the diagnostic criteria are identified as key issues for improving classification.

EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis

DEFF Research Database (Denmark)

Basu, Neil; Watts, Richard; Bajema, Ingeborg

2010-01-01

The systemic vasculitides are multiorgan diseases where early diagnosis and treatment can significantly improve outcomes. Robust nomenclature reduces diagnostic delay. However, key aspects of current nomenclature are widely perceived to be out of date, these include disease definitions, classific......, classification and diagnostic criteria. Therefore, the aim of the present work was to identify deficiencies and provide contemporary points to consider for the development of future definitions and criteria in systemic vasculitis....

Current status and prospects for Chernobyl Ukritiye

International Nuclear Information System (INIS)

Jampsin, B.

1996-01-01

Current status and prospects for Chernobyl Ukritiye (sarcophagus) are described, including the following issues: the accident; the sarcophagus; the radioactive inventory; the design basis criteria; the analysis of the present state; a way forward

Aerosol exposure: Concepts, criteria, standards and applications

International Nuclear Information System (INIS)

Vincent, James H

2009-01-01

This paper places Inhaled Particles X in the context of the whole sequence of such symposia, going back to the first one in 1961. It draws together some of the essential principles that have been learned since that earlier meeting about the nature of exposure and exposure assessment and thus provides a framework by which to integrate the new knowledge presented at this latest one. In the process, the importance of understanding the formal definition of aerosol exposure is stressed, including the distinction between exposure intensity and exposure history, and how that relates to some measure of cumulative dose which, in turn, may be linked with knowledge about intrinsic toxicity, etc. This then leads to a definition of exposure standards, and the important ingredients of criteria, sampling and limit values. A summary is provided of the current set of particle size-selective criteria that have been widely agreed in the international occupational and environmental health community. Some ideas are presented about how this set might be expanded for certain applications, the important case of ultrafine aerosols being one of them.

Cognitive impairment in schizophrenia and affective psychoses: implications for DSM-V criteria and beyond.

Science.gov (United States)

Bora, Emre; Yücel, Murat; Pantelis, Christos

2010-01-01

It has recently been suggested that the diagnostic criteria of schizophrenia should include specific reference to cognitive impairments characterizing the disorder. Arguments in support of this assertion contend that such inclusion would not only serve to increase the awareness of cognitive deficits in affected patients, among both clinicians and researchers alike, but also increase the "point of rarity" between schizophrenia and mood disorders. The aim of the current article is to examine this latter assertion in light of the recent opinion piece provided by Keefe and Fenton (Keefe RSE, Fenton WS. How should DSM-V criteria for schizophrenia include cognitive impairment? Schizophr Bull. 2007;33:912-920). Through literature review, we explore the issue of whether cognitive deficits do in fact differentiate the major psychoses. The overall results of this inquiry suggest that inclusion of cognitive impairment criteria in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-V) would not provide a major advancement in discriminating schizophrenia from bipolar disorder and affective psychoses. Therefore, while cognitive impairment should be included in DSM-V, it should not dictate diagnostic specificity--at least not until more comprehensive evidence-based reviews of the current diagnostic system have been undertaken. Based on this evidence, we consider several alternatives for the DSM-V definition of cognitive impairment in schizophrenia, including (1) the inclusion of cognitive impairment as a specifier and (2) the definition of cognitive impairment as a dimension within a hybrid categorical-dimensional system. Given the state of current evidence, these possibilities appear to represent the most parsimonious approaches to the inclusion of cognitive deficits in the diagnostic criteria of schizophrenia and, potentially, of mood disorders.

LMFBR safety criteria and guidelines for consideration in the design of future plants

International Nuclear Information System (INIS)

1990-01-01

For many years the Commission of the European Communities has been conducting activities aimed at the progressive harmonization of safety requirements and criteria applied to nuclear installations in the Community. These activities cover thermal and fast reactors. This publication represents a major achievement in reaching this goal. The document, which has been prepared in the framework of activities of the CEC fast-reactor safety working group (SWG), consists of safety criteria and guidelines for fast reactors. It represents the common view of all EC Member States which have a fast-reactor programme or are interested in fast-reactor development. The criteria and guidelines are structured according to different types of possible faults, such as core reactivity faults, general cooling faults, subassembly faults, faults outside the core and causes external to the station. Only those events are considered which are in the design basis of current fast-reactor projects. Proposed measures or guidelines to satisfy the criteria are based on the present knowledge and proven technology

Clinical Criteria Versus a Possible Research Case Definition in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Science.gov (United States)

Jason, Leonard A; McManimen, Stephanie; Sunnquist, Madison; Newton, Julia L; Strand, Elin Bolle

2017-01-01

The Institute of Medicine (IOM) recently developed clinical criteria for what had been known as chronic fatigue syndrome (CFS). Given the broad nature of the clinical IOM criteria, there is a need for a research definition that would select a more homogenous and impaired group of patients than the IOM clinical criteria. At the present time, it is unclear what will serve as the research definition. The current study focused on a research definition which selected homebound individuals who met the four IOM criteria, excluding medical and psychiatric co-morbidities. Our research criteria were compared to those participants meeting the IOM criteria. Those not meeting either of these criteria sets were placed in a separate group defined by 6 or more months of fatigue. Data analyzed were from the DePaul Symptom Questionnaire and the SF-36. Due to unequal sample sizes and variances, Welch's F tests and Games-Howell post hoc tests were conducted. Using a large database of over 1,000 patients from several countries, we found that those meeting a more restrictive research definition were even more impaired and more symptomatic than those meeting criteria for the other two groups. Deciding on a particular research case definition would allow researchers to select more comparable patient samples across settings, and this would represent one of the most significant methodologic advances for this field of study.

21 CFR 113.5 - Current good manufacturing practice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 113.5 Section... CONTAINERS General Provisions § 113.5 Current good manufacturing practice. The criteria in §§ 113.10, 113.40..., methods, practices, and controls used by the commercial processor in the manufacture, processing, or...

Home blood pressure monitoring and self-titration of antihypertensive medications: Proposed patient selection criteria.

Science.gov (United States)

Hill, James R

2016-05-01

Recent studies have demonstrated that home blood pressure monitoring (HBPM), coupled with self-titration of medications is a viable intervention to control hypertension. There are currently no established criteria to evaluate patients for inclusion in such a program. The purpose of this discussion is to propose criteria for determining if a patient is appropriate to participate in a program of HBPM and self-titration. Inclusion criteria for two self-titration trials were examined, and additional factors in clinical practice were identified and discussed. Additional selection criteria were proposed to support the decision to enroll a patient in an antihypertensive self-titration program. Inclusion criteria from self-titration trials provide a reasonable starting point for choosing appropriate patients in clinical practice, but additional research is necessary. Adaptation of these criteria and consideration of the identified factors can be used to develop decision support instruments. Such instruments should be evaluated for effectiveness and reliability prior to use in clinical practice. HBPM combined with self-titration is an effective patient-centered approach for hypertension management. Decision support instruments to determine appropriate patients are necessary for safe and effective use in clinical practice. ©2015 American Association of Nurse Practitioners.

Development on inelastic analysis acceptance criteria for radioactive material transportation packages

International Nuclear Information System (INIS)

Ammerman, D.J.; Ludwigsen, J.S.

1995-01-01

The response of radioactive material transportation packages to mechanical accident loadings can be more accurately characterized by non-linear dynamic analysis than by the ''Equivalent dynamic'' static elastic analysis typically used in the design of these packages. This more accurate characterization of the response can lead to improved package safety and design efficiency. For non-linear dynamic analysis to become the preferred method of package design analysis, an acceptance criterion must be established that achieves an equivalent level of safety as the currently used criterion defined in NRC Regulatory Guide 7.6 (NRC 1978). Sandia National Laboratories has been conducting a study of possible acceptance criteria to meet this requirement. In this paper non-linear dynamic analysis acceptance criteria based on stress, strain, and strain-energy-density will be discussed. An example package design will be compared for each of the design criteria, including the approach of NRC Regulatory Guide 7.6

Screening for Internet dependence: do the proposed diagnostic criteria differentiate normal from dependent Internet use?

Science.gov (United States)

Dowling, Nicki A; Quirk, Kelly L

2009-02-01

There is continued discussion of including Internet dependence as a diagnosis in future editions of the Diagnostic and Statistical Manual of Mental Disorders. The primary aim of the study was to evaluate the utility of the proposed diagnostic criteria for Internet dependence as measured by Young's Diagnostic Questionnaire (YDQ). Although the YDQ does not provide any measure of severity, there is emerging recognition that some Internet users may display less severe or at risk Internet dependence. The degree to which the cutoff of 5 out of 8 criteria is appropriate to differentiate nondependent from dependent Internet use was evaluated by comparing the Internet usage and psychological dysfunction of 424 university students endorsing 3 and 4 diagnostic criteria (at-risk Internet dependence) to those endorsing less than 3 criteria (nondependent) and those endorsing 5 or more criteria (Internet dependence). The findings suggest that the proposed diagnostic criteria do not adequately discriminate individuals scoring 3 or 4 from those currently classified as Internet dependent. The implications of the findings for the assessment, diagnosis, and treatment of Internet dependence are discussed.

Criteria for the designation of radioactively contaminated land

International Nuclear Information System (INIS)

Titley, J.; Mobbs, S.; Burgess, P.; Hitchins, G.; Sinclair, P.

1999-01-01

This report examines the criteria for the designation of radioactively contaminated land. It should be read in conjunction with reference to another output from the project i.e. Environment Agency report, Technical Support Material for the Regulation of Radioactively Contaminated Land 1999. This report deals with the intervention on radioactively contaminated sites i.e. where no change of land use is anticipated and where the land has become contaminated as a result of previous land use and not current practices. (author)

Genotype-dependent variation in the transpiration efficiency of plants and photosynthetic activity of flag leaves in spring barley under varied nutrition.

Science.gov (United States)

Krzemińska, Anetta; Górny, Andrzej G

2003-01-01

In the study, spring barley genotypes of various origin and breeding history were found to show a broad genetic variation in the vegetative and generative measures of the whole-plant transpiration efficiency (TE), photosynthesis (A) and transpiration (E) rates of flag leaves, leaf efficiency of gas exchange (A/E) and stress tolerance (T) when grown till maturity in soil-pots under high and reduced NPK supplies. Broad-sense heritabilities for the characteristics ranged from 0.61 to 0.87. Significant genotype-nutrition interactions were noticed, constituting 19-23% of the total variance in TE measures. The results suggest that at least some 'exotic' accessions from Ethiopia, Syria, Morocco and/or Tibet may serve as attractive genetic sources of novel variations in TE, T and A for the breeding of barleys of improved adaptation to less favourable fertilisation.

New particles and new currents

International Nuclear Information System (INIS)

Cashmore, R.J.

1979-01-01

In this report I want to review the impact of an ep machine on our present ideas and then speculate in what ways such an accelerator could investigate physics beyond our present framework. This speculation will lead to some criteria for the major parameters of such an accelerator, in particular the luminosity, energy and polarization of the electron beams. We will conclude that its principal advantages are: (i) The investigation of charged currents to mass scales beyond those accessible at LEP, (ii) the observation of new currents (charged or neutral) of either chirality coupling to leptons and quarks, (iii) the observation of new particles associated with such currents. (orig.)

Relationship between Admission Selection Criteria and Academic Progression for Student Nurse Anesthetists

Science.gov (United States)

Burns, Sharon M.

2009-01-01

Today's admission selection criteria require refinement with the intention of fostering academic progression for students entering nurse anesthesia programs (Reese, 2002).With the escalating cost of graduate education coupled with the current economic crisis, efforts by educational leaders to minimize attrition remains pivotal (Andrews, Johansson,…

Dual Criteria Decisions

DEFF Research Database (Denmark)

Andersen, Steffen; Harrison, Glenn W.; Lau, Morten Igel

2014-01-01

The most popular models of decision making use a single criterion to evaluate projects or lotteries. However, decision makers may actually consider multiple criteria when evaluating projects. We consider a dual criteria model from psychology. This model integrates the familiar tradeoffs between...... to the clear role that income thresholds play in such decision making, but does not rule out a role for tradeoffs between risk and utility or probability weighting....

Photosynthetic Characteristics of Flag Leaves in Rice White Stripe Mutant 6001 During Senescence Process

Directory of Open Access Journals (Sweden)

Xiao-hui ZHEN

2014-11-01

Full Text Available Physiological, biochemical and electron microscopy analyses were used to investigate the photosynthetic performance of flag leaves in rice white stripe mutant 6001 during the senescence process. Results showed that the chlorophyll content at the heading and milk-ripe stages in rice mutant 6001 were about 34.78% and 3.00% less than those in wild type 6028, respectively. However, the chlorophyll content at the fully-ripe stage in rice mutant 6001 was higher than that in wild type 6028. At the heading stage, the net photosynthetic rate (Pn in rice mutant 6001 was lower than that in wild type 6028. Rice mutant 6001 also exhibited a significantly slower decrease rate of Pn than wild type 6028 during the senescence progress, especially at the later stage. Furthermore, Ca2+-ATPase, Mg2+-ATPase and photophosphorylation activities exhibited the similar trends as the Pn. During the senescence process, the 68 kDa polypeptide concentrations in the thylakoid membrane proteins exhibited a significant change, which was one of the critical factors that contributed to the observed change in photosynthesis. We also observed that the chloroplasts of rice mutant 6001 exhibited higher integrity than those of wild type 6028, and the chloroplast membrane of rice mutant 6001 disintegrated more slow during the senescence process. In general, rice mutant 6001 had a relatively slower senescence rate than wild type 6028, and exhibited anti-senescence properties.

Failure Criteria for Reinforced Materials

DEFF Research Database (Denmark)

Rathkjen, Arne

Failure of materials is often characterized as ductile yielding, brittle fracture, creep rupture, etc., and different criteria given in terms of different parameters have been used to describe different types of failure. Only criteria expressing failure in terms of stress are considered in what...... place until the matrix, the continuous component of the composite, fails. When an isotropic matrix is reinforced as described above, the result is an anisotropic composite material. Even if the material is anisotropic, it usually exhibits a rather high degree of symmetry and such symmetries place...... certain restrictions on the form of the failure criteria for anisotropic materials. In section 2, some failure criteria for homogenous materials are reviewed. Both isotropic and anisotropic materials are described, and in particular the constraints imposed on the criteria from the symmetries orthotropy...

Defining criteria related to wastes for use in multi-criteria decision tool for nuclear accidents

Energy Technology Data Exchange (ETDEWEB)

Silva, Diogo N.G.; Guimaraes, Jean R.D., E-mail: dneves@biof.ufrj.br, E-mail: jeanrdg@biof.ufrj.br [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Instituto de Biofisica Carlos Chagas Filho; Rochedo, Elaine R.R.; De Luca, Christiano, E-mail: elainerochedo@gmail.com, E-mail: christiano_luca@hotmail.com [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear; Rochedo, Pedro R.R., E-mail: rochedopedro@gmail.com [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Instituto Alberto Luiz Coimbra de Pos-Graduacao e Pesquisa de Engenharia

2013-07-01

The selection of protective measures and strategies for remediation of contaminated areas after a nuclear accident must be based on previously established criteria in order to prevent stress of the population and the unnecessary exposure of workers. After a nuclear accident resulting in environmental contamination, decisions on remediation of areas is complex due to the large numbers of factors involved in decontamination processes. This work is part of a project which aims to develop a multi-criteria tool to support a decision-making process in cases of a radiological or a nuclear accident in Brazil. First, a database of remediation strategies for contaminated areas was created. In this process, the most relevant aspects for the implementation of these strategies were considered, including technical criteria regarding aspects related to the generation of wastes in a reference urban area, which are discussed in this paper. The specific objective of this study is to define criteria for the aspects of radioactive wastes, resulted by the implementation of some urban measures, in order to be incorporated in a multi-criteria decision tool. Main aspects considered were the type, the amount and the type of treatment necessary for each procedure. The decontamination procedures are then classified according to the selected criteria in order to feed the multi-criteria decision tool. This paper describes the steps for the establishment of these criteria and evaluates the potential for future applications in order to improve predictions and to support the decisions to be made. (author)

Defining criteria related to wastes for use in multi-criteria decision tool for nuclear accidents

International Nuclear Information System (INIS)

Silva, Diogo N.G.; Guimaraes, Jean R.D.; Rochedo, Elaine R.R.; De Luca, Christiano; Rochedo, Pedro R.R.

2013-01-01

The selection of protective measures and strategies for remediation of contaminated areas after a nuclear accident must be based on previously established criteria in order to prevent stress of the population and the unnecessary exposure of workers. After a nuclear accident resulting in environmental contamination, decisions on remediation of areas is complex due to the large numbers of factors involved in decontamination processes. This work is part of a project which aims to develop a multi-criteria tool to support a decision-making process in cases of a radiological or a nuclear accident in Brazil. First, a database of remediation strategies for contaminated areas was created. In this process, the most relevant aspects for the implementation of these strategies were considered, including technical criteria regarding aspects related to the generation of wastes in a reference urban area, which are discussed in this paper. The specific objective of this study is to define criteria for the aspects of radioactive wastes, resulted by the implementation of some urban measures, in order to be incorporated in a multi-criteria decision tool. Main aspects considered were the type, the amount and the type of treatment necessary for each procedure. The decontamination procedures are then classified according to the selected criteria in order to feed the multi-criteria decision tool. This paper describes the steps for the establishment of these criteria and evaluates the potential for future applications in order to improve predictions and to support the decisions to be made. (author)

Comparing new diagnostic criteria of 2010 ACR/EULAR with 1987 ACR criteria in rheumatoid arthritis

Directory of Open Access Journals (Sweden)

Fatemeh Shirani

2017-01-01

Full Text Available Background: Rheumatoid Arthritis (RA is a chronic inflammatory disease presenting with inflammation, tenderness and destruction of the synovial joints, resulting in severe disability and early death due to complication of disease. Previous diagnostic criteria are not useful for identifying patients who need early treatment. Thus, new diagnostic criteria for faster diagnosis of disease are introduced in 2010. The aim of this study was to compared 1987 ACR (American College of Rheumatology criteria and 2010 ACR/EULAR (European League Against Rheumatism classification criteria for diagnosis of rheumatoid arthritis. Methods: In this Cohort prospective study, patients with early arthritis were evaluated   according to the old and new diagnostic criteria and followed-up every two monthly for one year (2012-2013 in Hazrat-e Rasool University Hospital, Tehran. Inclusion criteria of this study were age more than 18 year and indefinite diagnosis of arthritis. For all of patients physical examination by expert rheumatologist was done and lab data include erythrocyte sedimentation rate (ESR, C-reactive protein (CRP, anti-cyclic citrullinated peptide (Anti-CCP and rheumatoid factor was requested. The sensitivity, specificity, positive and negative predictive values were then determined for each diagnostic criteria. Results: In this study 104 patients including 28 males (26.9% and 76 females (73.1% with the mean age of 44.2±13.7 years were included. At the end of one year follow-up, 82 were diagnosed to have RA while other 22 patients were not categorized as RA. Sensitivity for ESR, CRP, Anti-CCP and rheumatoid factor in 2010 ACR/EULAR criteria was 52%, 19%, 48%, 28% and specificity for them was 45%, 71%, 27%, 79% respectively. Number of small and large joint arthritis were more in patients with Rheumatoid Arthritis (RA rather than other arthritis (P=0.0001. Sensitivity and specificity for small joints involvement was 87% and 54% and for large joints

Multi-criteria decision-making for flood risk management: a survey of the current state of the art

Science.gov (United States)

Madruga de Brito, Mariana; Evers, Mariele

2016-04-01

This paper provides a review of multi-criteria decision-making (MCDM) applications to flood risk management, seeking to highlight trends and identify research gaps. A total of 128 peer-reviewed papers published from 1995 to June 2015 were systematically analysed. Results showed that the number of flood MCDM publications has exponentially grown during this period, with over 82 % of all papers published since 2009. A wide range of applications were identified, with most papers focusing on ranking alternatives for flood mitigation, followed by risk, hazard, and vulnerability assessment. The analytical hierarchy process (AHP) was the most popular method, followed by Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS), and Simple Additive Weighting (SAW). Although there is greater interest in MCDM, uncertainty analysis remains an issue and was seldom applied in flood-related studies. In addition, participation of multiple stakeholders has been generally fragmented, focusing on particular stages of the decision-making process, especially on the definition of criteria weights. Therefore, addressing the uncertainties around stakeholders' judgments and endorsing an active participation in all steps of the decision-making process should be explored in future applications. This could help to increase the quality of decisions and the implementation of chosen measures.

Site characterization criteria (DOE-STD-1022-94) for natural phenomena hazards at DOE sites

International Nuclear Information System (INIS)

Chen, J.C.; Ueng, T.S.; Boissonnade, A.C.

1995-12-01

This paper briefly summarizes requirements of site characterization for Natural Phenomena Hazards (NPH) at DOE sites. In order to comply with DOE Order 5480.28, site characterization criteria has been developed to provide site-specific information needed for development of NPH assessment criteria. Appropriate approaches are outlined to ensure that the current state-of-the-art methodologies and procedures are used in the site characterization. General and detailed site characterization requirements are provided in the areas of meteorology, hydrology, geology, seismology and geotechnical studies

CisLunar Habitat Internal Architecture Design Criteria

Science.gov (United States)

Jones, R.; Kennedy, K.; Howard, R.; Whitmore, M.; Martin, C.; Garate, J.

2017-01-01

BACKGROUND: In preparation for human exploration to Mars, there is a need to define the development and test program that will validate deep space operations and systems. In that context, a Proving Grounds CisLunar habitat spacecraft is being defined as the next step towards this goal. This spacecraft will operate differently from the ISS or other spacecraft in human history. The performance envelope of this spacecraft (mass, volume, power, specifications, etc.) is being defined by the Future Capabilities Study Team. This team has recognized the need for a human-centered approach for the internal architecture of this spacecraft and has commissioned a CisLunar Phase-1 Habitat Internal Architecture Study Team to develop a NASA reference configuration, providing the Agency with a "smart buyer" approach for future acquisition. THE CISLUNAR HABITAT INTERNAL ARCHITECTURE STUDY: Overall, the CisLunar Habitat Internal Architecture study will address the most significant questions and risks in the current CisLunar architecture, habitation, and operations concept development. This effort is achieved through definition of design criteria, evaluation criteria and process, design of the CisLunar Habitat Phase-1 internal architecture, and the development and fabrication of internal architecture concepts combined with rigorous and methodical Human-in-the-Loop (HITL) evaluations and testing of the conceptual innovations in a controlled test environment. The vision of the CisLunar Habitat Internal Architecture Study is to design, build, and test a CisLunar Phase-1 Habitat Internal Architecture that will be used for habitation (e.g. habitability and human factors) evaluations. The evaluations will mature CisLunar habitat evaluation tools, guidelines, and standards, and will interface with other projects such as the Advanced Exploration Systems (AES) Program integrated Power, Avionics, Software (iPAS), and Logistics for integrated human-in-the-loop testing. The mission of the Cis

Toxic chemical risk acceptance criteria

International Nuclear Information System (INIS)

Craig, D.K.; Davis, J.; Lee, L.; Lein, P.; Omberg, S.

1992-01-01

This paper presents recommendations of a subcommittee of the Westinghouse M ampersand 0 Nuclear Facility Safety Committee concerning toxic chemical risk acceptance criteria. Two sets of criteria have been developed, one for use in the hazard classification of facilities, and the second for use in comparing risks in DOE non-reactor nuclear facility Safety Analysis Reports. The Emergency Response Planning Guideline (ERPG) values are intended to provide estimates of concentration ranges for specific chemicals above which exposure would be expected to lead to adverse heath effects of increasing severity for ERPG-1, -2, and -3s. The subcommittee recommends that criteria for hazard class or risk range be based on ERPGs for all chemicals. Probability-based Incremental Cancer Risk (ICR) criteria are recommended for additional analyses of risks from all known or suspected human carcinogens. Criteria are given for both on-site and off-site exposure. The subcommittee also recommends that the 5-minute peak concentration be compared with the relevant criterion with no adjustment for exposure time. Since ERPGs are available for only a limited number of chemicals, the subcommittee has developed a proposed hierarchy of concentration limit parameters for the different criteria

Dynamic criteria for partitioning and transmutation

International Nuclear Information System (INIS)

Lu, A.H.

1991-11-01

This paper addresses dynamic criteria intended to optimize partitioning and transmutation (P-T) concept development supporting improved nuclear waste management. Six criteria are proposed initially and the rationale for each is briefly explained. Each criterion is used as a measure (or dimension) on which the developed concepts can be evaluated. The criteria allow the P-T concepts to be evaluated in an integral system including long-term energy needs, fuel cycle, and waste management. New criteria will be identified along with the P-T concept development, and each criterion will be realistically weighted so that it is comparable in an overall criteria evaluation. The weights are subject to change as a result of technical advancements and public perception on various issues. Incomplete criteria will result in a poor choice because important factors may not be considered when the decision is made. A successful decision on the optimal P-T system depends on the completeness of criteria (dimensions) as well as realistic weights assigned to each criterion

Photovoltaic system criteria documents. Volume 3: Environmental issues and evaluation criteria for photovoltaic applications

Science.gov (United States)

Koenig, John C.; Billitti, Joseph W.; Tallon, John M.

1979-01-01

The environmental issues and evaluation criteria relating to the suitability of sites proposed for photovoltaic (PV) system deployment are identified. The important issues are defined, briefly discussed and then developed into evaluation criteria. System designers are provided with information on the environmental sensitivity of PV systems in realistic applications, background material which indicates the applicability of the siting issues identified, and evaluation criteria are defined to facilitate the selection of sites that maximize PV system operation.

Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications

DEFF Research Database (Denmark)

Schiffman, Eric; Ohrbach, Richard; Truelove, Edmond

2014-01-01

of the literature providing valid instruments that, relative to the RDC/TMD, are shorter in length, are available in the public domain, and currently are being used in medical settings. RESULTS: The newly recommended Diagnostic Criteria for TMD (DC/TMD) Axis I protocol includes both a valid screener for detecting...

The DSM Diagnostic Criteria for Gender Identity Disorder in Adolescents and Adults

NARCIS (Netherlands)

Cohen-Kettenis, P.T.; Pfafflin, F.

2010-01-01

Apart from some general issues related to the Gender Identity Disorder (GID) diagnosis, such as whether it should stay in the DSM-V or not, a number of problems specifically relate to the current criteria of the GID diagnosis for adolescents and adults. These problems concern the confusion caused by

Radiological design criteria

International Nuclear Information System (INIS)

Selby, J.M.; Andersen, B.V.; Carter, L.A.; Waite, D.A.

1977-01-01

Many new nuclear facilities are unsatisfactory from a radiation protection point of view, particularly when striving to maintain occupational exposure as low as practicable 'ALAP'. Radiation protection is achieved through physical protective features supplemented by administrative controls. Adequate physical protective feature should be achieved during construction so that supplemental administrative controls may be kept simple and workable. Many nuclear facilities fall short of adequate physical protective features, thus, remedial and sometimes awkward administrative procedures are required to safely conduct work. In reviewing the various handbooks, reports and regulations which deal with radiation protection, it may be noted that there is minimal radiological design guidance for application to nuclear facilities. A set of criteria or codes covering functional areas rather than specific nuclear facility types is badly needed. The following are suggested as functional areas to be considered: characterization of the Facility; siting and access; design exposure limits; layout (people and materials flow); ventilation and effluent control; radiation protection facilities and systems. The application of such radiological design criteria early in the design process would provide some assurance that nuclear facilities will be safe, flexible, and efficient with a minimum of costly retrofitting or administrative restrictions. Criteria which we have found helpful in these functional areas is discussed together with justification for adoption of such criteria and identification of problems which still require solution

ACR Appropriateness Criteria® Tinnitus.

Science.gov (United States)

Kessler, Marcus M; Moussa, Marwan; Bykowski, Julie; Kirsch, Claudia F E; Aulino, Joseph M; Berger, Kevin L; Choudhri, Asim F; Fife, Terry D; Germano, Isabelle M; Kendi, A Tuba; Kim, Jeffrey H; Luttrull, Michael D; Nunez, Diego; Shah, Lubdha M; Sharma, Aseem; Shetty, Vilaas S; Symko, Sophia C; Cornelius, Rebecca S

2017-11-01

Tinnitus is the perception of sound in the absence of an external source. It is a common symptom that can be related to hearing loss and other benign causes. However, tinnitus may be disabling and can be the only symptom in a patient with a central nervous system process disorder. History and physical examination are crucial first steps to determine the need for imaging. CT and MRI are useful in the setting of pulsatile tinnitus to evaluate for an underlying vascular anomaly or abnormality. If there is concomitant asymmetric hearing loss, neurologic deficit, or head trauma, imaging should be guided by those respective ACR Appropriateness Criteria ® documents, rather than the presence of tinnitus. Imaging is not usually appropriate in the evaluation of subjective, nonpulsatile tinnitus that does not localize to one ear. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Sediment quality criteria: A review with recommendations for developing criteria for the Hanford Site

Energy Technology Data Exchange (ETDEWEB)

Driver, C.J.

1994-05-01

Criteria for determining the quality of liver sediment are necessary to ensure that concentrations of contaminants in aquatic systems are within acceptable limits for the protection of aquatic and human life. Such criteria should facilitate decision-making about remediation, handling, and disposal of contaminants. Several approaches to the development of sediment quality criteria (SQC) have been described and include both descriptive and numerical methods. However, no single method measures all impacts at all times to all organisms (U.S. EPA 1992b). The U.S. EPA`s interest is primarily in establishing chemically based, numerical SQC that are applicable nation-wide (Shea 1988). Of the approaches proposed for SQC development, only three are being considered for numerical SQC on a national level. These approaches include an Equilibrium Partitioning Approach, a site-specific method using bioassays (the Apparent Effects Threshold Approach), and an approach similar to EPA`s water quality criteria (Pavlou and Weston 1984). Although national (or even regional) criteria address a number of political, litigative, and engineering needs, some researchers feel that protection of benthic communities require site-specific, biologically based criteria (Baudo et al. 1990). This is particularly true for areas where complex mixtures of contaminants are present in sediments. Other scientifically valid and accepted procedures for freshwater SQC include a background concentration approach, methods using field or spiked bioassays, a screening level concentration approach, the Apparent Effects Threshold Approach, the Sediment Quality Triad, the International Joint Commission Sediment Assessment Strategy, and the National Status and Trends Program Approach. The various sediment assessment approaches are evaluated for application to the Hanford Reach and recommendations for Hanford Site sediment quality criteria are discussed.

Noninductive current drive in tokamaks

International Nuclear Information System (INIS)

Uckan, N.A.

1985-01-01

Various current drive mechanisms may be grouped into four classes: (1) injection of energetic particle beams; (2) launching of rf waves; (3) hybrid schemes, which are combinations of various rf schemes (rf plus beams, rf and/or beam plus ohmic heating, etc.); and (4) other schemes, some of which are specific to reactor plasma conditions requiring the presence of alpha particle or intense synchrotron radiation. Particle injection schemes include current drive by neutral beams and relativistic electron beams. The rf schemes include current drive by the lower hybrid (LH) waves, the electron waves, the waves in the ion cyclotron range of frequencies, etc. Only a few of these approaches, however, have been tested experimentally, with the broadest data base available for LH waves. Included in this report are (1) efficiency criteria for current drive, (2) current drive by neutral beam injection, (3) LH current drive, (4) electron cyclotron current drive, (5) current drive by ion cyclotron waves - minority species heating, and (6) current drive by other schemes (such as hybrids and low frequency waves)

Sustainable transport project evaluation and decision support: indicators and planning criteria for sustainable development

DEFF Research Database (Denmark)

Salling, Kim Bang; Pryn, Marie Ridley

2015-01-01

is adopted. The SUSTAIN-DSS model rests upon multi-criteria decision analysis and planning workshops in order to combine the use of qualitative and quantitative assessments. This article stresses the necessity of revising current planning paradigms such as cost-benefit analysis (CBA) but also to make clear......This article will expose the necessity for a sustainable planning and decision support framework for transport infrastructure assessment. This will be operationalized through a set of planning criteria and scenario alternatives, which is assessed in the SUSTAIN decision support system (SUSTAIN......-DSS) model. A part of the decision support framework will be tested in a case study in Denmark, concerning the problem of congestion on the current bridge crossing Roskilde Fjord in the city of Frederikssund. This article suggests including in a combination both reference class forecasting and quantitative...

Criteria for Authorship in Bioethics

OpenAIRE

Resnik, David B.; Master, Zubin

2011-01-01

Multiple authorship is becoming increasingly common in bioethics research. There are well-established criteria for authorship in empirical bioethics research but not for conceptual research. It is important to develop criteria for authorship in conceptual publications to prevent undeserved authorship and uphold standards of fairness and accountability. This article explores the issue of multiple authorship in bioethics and develops criteria for determining who should be an author on a concept...

AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions.

Science.gov (United States)

Paice, Judith A; Mulvey, Matt; Bennett, Michael; Dougherty, Patrick M; Farrar, John T; Mantyh, Patrick W; Miaskowski, Christine; Schmidt, Brian; Smith, Thomas J

2017-03-01

Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy initiative worked to develop the characteristics of an optimal diagnostic system. After the establishment of these characteristics, a working group consisting of clinicians and clinical and basic scientists with expertise in cancer and cancer-related pain was convened to generate core diagnostic criteria for an illustrative sample of 3 chronic pain syndromes associated with cancer (ie, bone pain and pancreatic cancer pain as models of pain related to a tumor) or its treatment (ie, chemotherapy-induced peripheral neuropathy). A systematic review and synthesis was conducted to provide evidence for the dimensions that comprise this cancer pain taxonomy. Future efforts will subject these diagnostic categories and criteria to systematic empirical evaluation of their feasibility, reliability, and validity and extension to other cancer-related pain syndromes. The ACTTION-APS chronic cancer pain taxonomy provides an evidence-based classification for 3 prevalent syndromes, namely malignant bone pain, pancreatic cancer pain, and chemotherapy-induced peripheral neuropathy. This taxonomy provides consistent diagnostic criteria, common features, comorbidities, consequences, and putative mechanisms for these potentially serious cancer pain conditions that can be extended and applied with other cancer

The application of strength and power related field tests in older adults : criteria, current status and a future perspective

NARCIS (Netherlands)

Regterschot, G. Ruben H.; Morat, Tobias; Folkersma, Marjanne; Zijlstra, Wiebren

2015-01-01

Leg muscle strength (LMS) and leg muscle power (LMP) are determinants of aspects of functional status and important parameters for measuring intervention effects in older adults. Field tests are often used for the evaluation of LMS and LMP in older persons. However, criteria important for the

Expanding the Taxonomy of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD)

Science.gov (United States)

Peck, Christopher C.; Goulet, Jean-Paul; Lobbezoo, Frank; Schiffman, Eric L.; Alstergren, Per; Anderson, Gary C.; de Leeuw, Reny; Jensen, Rigmor; Michelotti, Ambra; Ohrbach, Richard; Petersson, Arne; List, Thomas

2014-01-01

Background There is a need to expand the current temporomandibular disorder (TMD) classification to include less common, but clinically important disorders. The immediate aim was to develop a consensus-based classification system and associated diagnostic criteria that have clinical and research utility for less common TMDs. The long-term aim was to establish a foundation, vis-à-vis this classification system, that will stimulate data collection, validity testing, and further criteria refinement. Methods A working group [members of the International RDC/TMD Consortium Network of the International Association for Dental Research (IADR), members of the Orofacial Pain Special Interest Group (SIG) of the International Association for the Study of Pain (IASP), and members from other professional societies] reviewed disorders for inclusion based on clinical significance, the availability of plausible diagnostic criteria, and the ability to operationalize and study the criteria. The disorders were derived from the literature when possible and based on expert opinion as necessary. The expanded TMD taxonomy was presented for feedback at international meetings. Results Of 56 disorders considered, 37 were included in the expanded taxonomy and were placed into the following four categories: temporomandibular joint disorders, masticatory muscle disorders, headache disorders, and disorders affecting associated structures. Those excluded were extremely uncommon, lacking operationalized diagnostic criteria, not clearly related to TMDs, or not sufficiently distinct from disorders already included within the taxonomy. Conclusions The expanded TMD taxonomy offers an integrated approach to clinical diagnosis and provides a framework for further research to operationalize and test the proposed taxonomy and diagnostic criteria. PMID:24443898

A Framework for Human Performance Criteria for Advanced Reactor Operational Concepts

Energy Technology Data Exchange (ETDEWEB)

Jacques V Hugo; David I Gertman; Jeffrey C Joe

2014-08-01

This report supports the determination of new Operational Concept models needed in support of the operational design of new reactors. The objective of this research is to establish the technical bases for human performance and human performance criteria frameworks, models, and guidance for operational concepts for advanced reactor designs. The report includes a discussion of operating principles for advanced reactors, the human performance issues and requirements for human performance based upon work domain analysis and current regulatory requirements, and a description of general human performance criteria. The major findings and key observations to date are that there is some operating experience that informs operational concepts for baseline designs for SFR and HGTRs, with the Experimental Breeder Reactor-II (EBR-II) as a best-case predecessor design. This report summarizes the theoretical and operational foundations for the development of a framework and model for human performance criteria that will influence the development of future Operational Concepts. The report also highlights issues associated with advanced reactor design and clarifies and codifies the identified aspects of technology and operating scenarios.

Waste-acceptance criteria and risk-based thinking for radioactive-waste classification

International Nuclear Information System (INIS)

Lowenthal, M.D.

1998-01-01

The US system of radioactive-waste classification and its development provide a reference point for the discussion of risk-based thinking in waste classification. The official US system is described and waste-acceptance criteria for disposal sites are introduced because they constitute a form of de facto waste classification. Risk-based classification is explored and it is found that a truly risk-based system is context-dependent: risk depends not only on the waste-management activity but, for some activities such as disposal, it depends on the specific physical context. Some of the elements of the official US system incorporate risk-based thinking, but like many proposed alternative schemes, the physical context of disposal is ignored. The waste-acceptance criteria for disposal sites do account for this context dependence and could be used as a risk-based classification scheme for disposal. While different classes would be necessary for different management activities, the waste-acceptance criteria would obviate the need for the current system and could better match wastes to disposal environments saving money or improving safety or both

Environmental risk assessment: its contribution to criteria development for HLW disposal

International Nuclear Information System (INIS)

Smith, G.M.; Little, R.H.; Watkins, B.M.

1999-01-01

Principles for radioactive waste management have been provided by the International Atomic Energy Agency in Safety Series No.111-F, which was published in 1995. This has been a major step forward in the process of achieving acceptance for proposals for disposal of radioactive waste, for example, for High Level Waste disposal in deep repositories. However, these principles have still to be interpreted and developed into practical radiation protection criteria. Without prejudicing final judgements on the acceptability of waste proposals, an important aspect is that practical demonstration of compliance (or the opposite) with these criteria must be possible. One of the IAEA principles requires that radioactive waste shall be managed in such a way as to provide an acceptable level of protection of the environment. There has been and continues to be considerable debate as to how to demonstrate compliance with such a principle. This paper briefly reviews the current status and considers how experience in other areas of environmental protection could contribute to criteria development for HLW disposal

Functional Design Criteria - plutonium stabilization and handling (PUSH) project W-460

International Nuclear Information System (INIS)

NELSON, D.W.

1999-01-01

This Functional Design Criteria (FDC) contains information to guide the design of the Stabilization and Packaging Equipment necessary to oxidize and package the remaining plutonium-bearing Special Nuclear Materials (SNM) currently in the Plutonium Finishing Plant (PFP) inventory. The FDC also guides the design of vault modifications to allow storage of 3013 packages of stabilized SNM for up to 50 years

Functional Design Criteria plutonium stabilization and handling (PUSH) project W-460

Energy Technology Data Exchange (ETDEWEB)

NELSON, D.W.

1999-09-02

This Functional Design Criteria (FDC) contains information to guide the design of the Stabilization and Packaging Equipment necessary to oxidize and package the remaining plutonium-bearing Special Nuclear Materials (SNM) currently in the Plutonium Finishing Plant (PFP) inventory. The FDC also guides the design of vault modifications to allow storage of 3013 packages of stabilized SNM for up to 50 years.

Temporal stability of diagnostic criteria for antisocial personality disorder in male alcohol dependent patients

NARCIS (Netherlands)

Verheul, R.; van den Brink, W.; Koeter, M. W.

1998-01-01

We evaluated the temporal stability of diagnostic criteria for antisocial personality disorder in 432 male alcohol dependent patients. Indicators for temporal stability were criterion continuation (i.e., the proportion of current or recent diagnoses among those with a lifetime diagnosis) and

Gender differences in developmental dyscalculia depend on diagnostic criteria.

Science.gov (United States)

Devine, Amy; Soltész, Fruzsina; Nobes, Alison; Goswami, Usha; Szűcs, Dénes

2013-10-01

Developmental dyscalculia (DD) is a learning difficulty specific to mathematics learning. The prevalence of DD may be equivalent to that of dyslexia, posing an important challenge for effective educational provision. Nevertheless, there is no agreed definition of DD and there are controversies surrounding cutoff decisions, specificity and gender differences. In the current study, 1004 British primary school children completed mathematics and reading assessments. The prevalence of DD and gender ratio were estimated in this sample using different criteria. When using absolute thresholds, the prevalence of DD was the same for both genders regardless of the cutoff criteria applied, however gender differences emerged when using a mathematics-reading discrepancy definition. Correlations between mathematics performance and the control measures selected to identify a specific learning difficulty affect both prevalence estimates and whether a gender difference is in fact identified. Educational implications are discussed.

Cognitive and Adaptive Skills in Toddlers Who Meet Criteria for Autism in DSM-IV but Not DSM-5

Science.gov (United States)

Jashar, Dasal Tenzin; Brennan, Laura A.; Barton, Marianne L.; Fein, Deborah

2016-01-01

The current study compared adaptive and cognitive skills, and autism severity of toddlers with an autism spectrum disorder (ASD) diagnosis under DSM-IV but not DSM-5 criteria (DSM-IV only group) to those who met autism criteria under both diagnostic systems (DSM-5 group) and to those without ASD (non-ASD group). The toddlers in the DSM-IV only…

Adaptation and Evaluation of a Multi-Criteria Decision Analysis Model for Lyme Disease Prevention.

Directory of Open Access Journals (Sweden)

Cécile Aenishaenslin

Full Text Available Designing preventive programs relevant to vector-borne diseases such as Lyme disease (LD can be complex given the need to include multiple issues and perspectives into prioritizing public health actions. A multi-criteria decision aid (MCDA model was previously used to rank interventions for LD prevention in Quebec, Canada, where the disease is emerging. The aim of the current study was to adapt and evaluate the decision model constructed in Quebec under a different epidemiological context, in Switzerland, where LD has been endemic for the last thirty years. The model adaptation was undertaken with a group of Swiss stakeholders using a participatory approach. The PROMETHEE method was used for multi-criteria analysis. Key elements and results of the MCDA model are described and contrasted with the Quebec model. All criteria and most interventions of the MCDA model developed for LD prevention in Quebec were directly transferable to the Swiss context. Four new decision criteria were added, and the list of proposed interventions was modified. Based on the overall group ranking, interventions targeting human populations were prioritized in the Swiss model, with the top ranked action being the implementation of a large communication campaign. The addition of criteria did not significantly alter the intervention rankings, but increased the capacity of the model to discriminate between highest and lowest ranked interventions. The current study suggests that beyond the specificity of the MCDA models developed for Quebec and Switzerland, their general structure captures the fundamental and common issues that characterize the complexity of vector-borne disease prevention. These results should encourage public health organizations to adapt, use and share MCDA models as an effective and functional approach to enable the integration of multiple perspectives and considerations in the prevention and control of complex public health issues such as Lyme disease or

Adaptation and Evaluation of a Multi-Criteria Decision Analysis Model for Lyme Disease Prevention.

Science.gov (United States)

Aenishaenslin, Cécile; Gern, Lise; Michel, Pascal; Ravel, André; Hongoh, Valérie; Waaub, Jean-Philippe; Milord, François; Bélanger, Denise

2015-01-01

Designing preventive programs relevant to vector-borne diseases such as Lyme disease (LD) can be complex given the need to include multiple issues and perspectives into prioritizing public health actions. A multi-criteria decision aid (MCDA) model was previously used to rank interventions for LD prevention in Quebec, Canada, where the disease is emerging. The aim of the current study was to adapt and evaluate the decision model constructed in Quebec under a different epidemiological context, in Switzerland, where LD has been endemic for the last thirty years. The model adaptation was undertaken with a group of Swiss stakeholders using a participatory approach. The PROMETHEE method was used for multi-criteria analysis. Key elements and results of the MCDA model are described and contrasted with the Quebec model. All criteria and most interventions of the MCDA model developed for LD prevention in Quebec were directly transferable to the Swiss context. Four new decision criteria were added, and the list of proposed interventions was modified. Based on the overall group ranking, interventions targeting human populations were prioritized in the Swiss model, with the top ranked action being the implementation of a large communication campaign. The addition of criteria did not significantly alter the intervention rankings, but increased the capacity of the model to discriminate between highest and lowest ranked interventions. The current study suggests that beyond the specificity of the MCDA models developed for Quebec and Switzerland, their general structure captures the fundamental and common issues that characterize the complexity of vector-borne disease prevention. These results should encourage public health organizations to adapt, use and share MCDA models as an effective and functional approach to enable the integration of multiple perspectives and considerations in the prevention and control of complex public health issues such as Lyme disease or other vector

National Recommended Water Quality Criteria

Data.gov (United States)

U.S. Environmental Protection Agency — The National Recommended Water Quality Criteria is a compilation of national recommended water quality criteria for the protection of aquatic life and human health...

Downstaging therapy followed by liver transplantation for hepatocellular carcinoma beyond Milan criteria.

Science.gov (United States)

Kim, Young; Stahl, Christopher C; Makramalla, Abouelmagd; Olowokure, Olugbenga O; Ristagno, Ross L; Dhar, Vikrom K; Schoech, Michael R; Chadalavada, Seetharam; Latif, Tahir; Kharofa, Jordan; Bari, Khurram; Shah, Shimul A

2017-12-01

Orthotopic liver transplantation is a curative treatment for hepatocellular carcinoma within Milan criteria, but these criteria preclude many patients from transplant candidacy. Recent studies have demonstrated that downstaging therapy can reduce tumor burden to meet conventional criteria. The present study reports a single-center experience with tumor downstaging and its effects on post-orthotopic liver transplantation outcomes. All patients with hepatocellular carcinoma who were evaluated by our multidisciplinary liver services team from 2012 to 2016 were identified (N = 214). Orthotopic liver transplantation candidates presenting outside of Milan criteria at initial radiographic diagnosis and/or an initial alpha-fetoprotein >400 ng/mL were categorized as at high risk for tumor recurrence and post-transplant mortality. Of the 214 patients newly diagnosed with hepatocellular carcinoma, 73 (34.1%) eventually underwent orthotopic liver transplantation. The majority of patients who did not undergo orthotopic liver transplantation were deceased or lost to follow-up (47.5%), with 14 of 141 (9.9%) currently listed for transplantation. Among transplanted patients, 21 of 73 (28.8%) were considered high-risk candidates. All 21 patients were downstaged to within Milan criteria with an alpha-fetoprotein hepatocellular carcinoma was higher but acceptable between downstaged high-risk and traditional candidates (9.5% vs 1.9%; P > .05) at a median follow-up period of 17 months. Downstaged high-risk candidates had a similar overall survival compared with those transplanted within Milan criteria (log-rank P > .05). In highly selected cases, patients with hepatocellular carcinoma outside of traditional criteria for orthotopic liver transplantation may undergo downstaging therapy in a multidisciplinary fashion with excellent post-transplant outcomes. These data support an aggressive downstaging approach for selected patients who would otherwise be deemed ineligible for

Study on the locational criteria for submarine rock repositories of low and medium level radioactive wastes

Energy Technology Data Exchange (ETDEWEB)

Kim, G H; Kang, W J; Kim, T J. and others [Chungnam National Univ., Taejon (Korea, Republic of)

1992-01-15

Submarine repositories have significant advantages over their land counterparts locating close to the areas of daily human activities. Consequently, the construction of submarine repositories on the vast continental shelves around Korean seas is considered to be highly positive. In this context, the development of locational criteria primarily targeting the safety of submarine rock repositories is very important.The contents of the present study are: analyzing characteristics of marine environment: Search of potential hazards to, and environmental impact by, the submarine repositories; Investigation of the oceanographic, geochemical, ecological and sedimentological characteristics of estuaries and coastal seas. Locating potential hazards to submarine repositories by: Bibliographical search of accidents leading to the destruction of submarine structures by turbidity currents and other potentials; Review of turbidity currents. Consideration of environmental impact caused by submarine repositories: Logistics to minimize the environmental impacts in site selection; Removal and dispersion processes of radionuclides in sea water. Analyses of oceanographical characteristics of, and hazard potentials in, the Korean seas. Evaluation of the MOST 91-7 criteria for applicability to submarine repositories and the subsequent proposition of additional criteria.

Study on the locational criteria for submarine rock repositories of low and medium level radioactive wastes

International Nuclear Information System (INIS)

Kim, G. H.; Kang, W. J.; Kim, T. J. and others

1992-01-01

Submarine repositories have significant advantages over their land counterparts locating close to the areas of daily human activities. Consequently, the construction of submarine repositories on the vast continental shelves around Korean seas is considered to be highly positive. In this context, the development of locational criteria primarily targeting the safety of submarine rock repositories is very important.The contents of the present study are: analyzing characteristics of marine environment: Search of potential hazards to, and environmental impact by, the submarine repositories; Investigation of the oceanographic, geochemical, ecological and sedimentological characteristics of estuaries and coastal seas. Locating potential hazards to submarine repositories by: Bibliographical search of accidents leading to the destruction of submarine structures by turbidity currents and other potentials; Review of turbidity currents. Consideration of environmental impact caused by submarine repositories: Logistics to minimize the environmental impacts in site selection; Removal and dispersion processes of radionuclides in sea water. Analyses of oceanographical characteristics of, and hazard potentials in, the Korean seas. Evaluation of the MOST 91-7 criteria for applicability to submarine repositories and the subsequent proposition of additional criteria

Wind turbine performance: Methods and criteria for reliability of measured power curves

Energy Technology Data Exchange (ETDEWEB)

Griffin, D.A. [Advanced Wind Turbines Inc., Seattle, WA (United States)

1996-12-31

In order to evaluate the performance of prototype turbines, and to quantify incremental changes in performance through field testing, Advanced Wind Turbines (AWT) has been developing methods and requirements for power curve measurement. In this paper, field test data is used to illustrate several issues and trends which have resulted from this work. Averaging and binning processes, data hours per wind-speed bin, wind turbulence levels, and anemometry methods are all shown to have significant impacts on the resulting power curves. Criteria are given by which the AWT power curves show a high degree of repeatability, and these criteria are compared and contrasted with current published standards for power curve measurement. 6 refs., 5 figs., 5 tabs.

Multi-criteria model to support decision-making for the remediation of urban areas

International Nuclear Information System (INIS)

De Luca, Christiano; Lopes, Ricardo T.; Silva, Diogo N.G.; Guimaraes, Jean R.D.

2015-01-01

Under the environmental modeling Project of radioecology research area of IRD (CNEN), several tools have been developed to support post-emergency activities. Currently, a multi-criteria model is in development with the aim of supporting decision-making processes under the radiological protection point of view. At this stage, we are focusing on the decontamination of urban areas. The model includes five calculation modules: (1) averted doses to the public due to remediation procedures; (2) occupational exposure of remediation workers; (3) properties of the wastes generated by a remediation procedure; (4) classification of each procedure for a specific urban scenario based on previously calculated quantities; and, (5) multi-criteria rank calculation. The classification of procedures is based on two types of criteria previously defined, both also included as input data of the model. The first type, called Subjective Criteria, is based on experts' opinions collected through questionnaires. The second type, called Technical Criteria, is calculated according to the outputs of the three first modules of the program. The output of the model is a rank order list indicating the priority of procedures to use for each different type of urban environment. The use of results based on criteria and methods developed previously to the occurrence of a contamination event intends not only to provide an input to decision-making processes but also to improve public confidence on authorities responsible for the remediation decisions. (author)

Multi-criteria model to support decision-making for the remediation of urban areas

Energy Technology Data Exchange (ETDEWEB)

De Luca, Christiano; Lopes, Ricardo T., E-mail: christiano_luca@hotmail.com, E-mail: ricardo@lin.ufrj.br [Coordenacao dos Programas de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear; Rochedo, Elaine R.R., E-mail: elainerochedo@gmail.com [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Silva, Diogo N.G.; Guimaraes, Jean R.D., E-mail: diogons@gmail.com, E-mail: jeanrdg@biof.ufrj.br [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Instituto de Biofisica Carlos Chagas Filho; Rochedo, Pedro R.R., E-mail: rochedopedro@gmail.com [Coordenacao dos Programas de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de de Planejamento Energetico; Wasserman, Maria Angelica V., E-mail: mwasserman@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2015-07-01

Under the environmental modeling Project of radioecology research area of IRD (CNEN), several tools have been developed to support post-emergency activities. Currently, a multi-criteria model is in development with the aim of supporting decision-making processes under the radiological protection point of view. At this stage, we are focusing on the decontamination of urban areas. The model includes five calculation modules: (1) averted doses to the public due to remediation procedures; (2) occupational exposure of remediation workers; (3) properties of the wastes generated by a remediation procedure; (4) classification of each procedure for a specific urban scenario based on previously calculated quantities; and, (5) multi-criteria rank calculation. The classification of procedures is based on two types of criteria previously defined, both also included as input data of the model. The first type, called Subjective Criteria, is based on experts' opinions collected through questionnaires. The second type, called Technical Criteria, is calculated according to the outputs of the three first modules of the program. The output of the model is a rank order list indicating the priority of procedures to use for each different type of urban environment. The use of results based on criteria and methods developed previously to the occurrence of a contamination event intends not only to provide an input to decision-making processes but also to improve public confidence on authorities responsible for the remediation decisions. (author)

Water quality criteria for lead

Energy Technology Data Exchange (ETDEWEB)

Nagpal, N.K.

1987-01-01

This report is one in a series that establishes water quality criteria for British Columbia. The report sets criteria for lead to protect a number of water uses, including drinking water, freshwater and marine aquatic life, wildlife, livestock, irrigation, and recreation. The criteria are set as either maximum concentrations of total lead that should not be exceeded at any time, or average concentrations that should not be exceeded over a 30-day period. Actual values are summarized.

Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition.

Science.gov (United States)

Coccaro, Emil F

2011-01-01

This study was designed to develop a revised diagnostic criteria set for intermittent explosive disorder (IED) for consideration for inclusion in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). This revised criteria set was developed by integrating previous research criteria with elements from the current DSM-IV set of diagnostic criteria. Evidence supporting the reliability and validity of IED-IR ("IED Integrated Criteria") in a new and well-characterized group of subjects with personality disorder is presented. Clinical, phenomenologic, and diagnostic data from 201 individuals with personality disorder were reviewed. All IED diagnoses were assigned using a best-estimate process (eg, kappa for IED-IR >0.85). In addition, subjects meeting IED-IR criteria had higher scores on dimensional measures of aggression and had lower global functioning scores than non-IED-IR subjects, even when related variables were controlled. The IED-IR criteria were more sensitive than the DSM-IV criteria only in identifying subjects with significant impulsive-aggressive behavior by a factor of 16. We conclude that the IED-IR criteria can be reliably applied and have sufficient validity to warrant consideration as DSM-V criteria for IED. Copyright © 2011 Elsevier Inc. All rights reserved.

46 CFR 385.51 - Criteria: Projects.

Science.gov (United States)

2010-10-01

... results; (iii) The extent of the problems treated and whether the objectives sought by the undertaking are... MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MISCELLANEOUS RESEARCH AND DEVELOPMENT GRANT AND COOPERATIVE AGREEMENTS REGULATIONS Criteria for Award § 385.51 Criteria: Projects. The criteria to be used by...

Engineering design of a high-temperature superconductor current lead

International Nuclear Information System (INIS)

Niemann, R.C.; Cha, Y.S.; Hull, J.R.; Daugherty, M.A.; Buckles, W.E.

1993-01-01

As part of the US Department of Energy's Superconductivity Pilot Center Program, Argonne National Laboratory and Superconductivity, Inc., are developing high-temperature superconductor (HTS) current leads suitable for application to superconducting magnetic energy storage systems. The principal objective of the development program is to design, construct, and evaluate the performance of HTS current leads suitable for near-term applications. Supporting objectives are to (1) develop performance criteria; (2) develop a detailed design; (3) analyze performance; (4) gain manufacturing experience in the areas of materials and components procurement, fabrication and assembly, quality assurance, and cost; (5) measure performance of critical components and the overall assembly; (6) identify design uncertainties and develop a program for their study; and (7) develop application-acceptance criteria

Engineering design of a high-temperature superconductor current lead

Science.gov (United States)

Niemann, R. C.; Cha, Y. S.; Hull, J. R.; Daugherty, M. A.; Buckles, W. E.

As part of the US Department of Energy's Superconductivity Pilot Center Program, Argonne National Laboratory and Superconductivity, Inc., are developing high-temperature superconductor (HTS) current leads suitable for application to superconducting magnetic energy storage systems. The principal objective of the development program is to design, construct, and evaluate the performance of HTS current leads suitable for near-term applications. Supporting objectives are to (1) develop performance criteria; (2) develop a detailed design; (3) analyze performance; (4) gain manufacturing experience in the areas of materials and components procurement, fabrication and assembly, quality assurance, and cost; (5) measure performance of critical components and the overall assembly; (6) identify design uncertainties and develop a program for their study; and (7) develop application-acceptance criteria.

Criteria for saturated magnetization loop

International Nuclear Information System (INIS)

Harres, A.; Mikhov, M.; Skumryev, V.; Andrade, A.M.H. de; Schmidt, J.E.; Geshev, J.

2016-01-01

Proper estimation of magnetization curve parameters is vital in studying magnetic systems. In the present article, criteria for discrimination non-saturated (minor) from saturated (major) hysteresis loops are proposed. These employ the analysis of (i) derivatives of both ascending and descending branches of the loop, (ii) remanent magnetization curves, and (iii) thermomagnetic curves. Computational simulations are used in order to demonstrate their validity. Examples illustrating the applicability of these criteria to well-known real systems, namely Fe_3O_4 and Ni fine particles, are provided. We demonstrate that the anisotropy-field value estimated from a visual examination of an only apparently major hysteresis loop could be more than two times lower than the real one. - Highlights: • Proper estimation of hysteresis-loop parameters is vital in magnetic studies. • We propose criteria for discrimination minor from major hysteresis loops. • The criteria analyze magnetization, remanence and ZFC/FC curves and/or their derivatives. • Examples of their application on real nanoparticles systems are given. • Using the criteria could avoid twofold or bigger saturation-field underestimation errors.

Criteria for saturated magnetization loop

Energy Technology Data Exchange (ETDEWEB)

Harres, A. [Departamento de Física, UFSM, Santa Maria, 97105-900 Rio Grande do Sul (Brazil); Mikhov, M. [Faculty of Physics, University of Sofia, 1164 Sofia (Bulgaria); Skumryev, V. [Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona (Spain); Departament de Física, Universitat Autònoma de Barcelona, 08193 Barcelona (Spain); Andrade, A.M.H. de; Schmidt, J.E. [Instituto de Física, UFRGS, Porto Alegre, 91501-970 Rio Grande do Sul (Brazil); Geshev, J., E-mail: julian@if.ufrgs.br [Departament de Física, Universitat Autònoma de Barcelona, 08193 Barcelona (Spain); Instituto de Física, UFRGS, Porto Alegre, 91501-970 Rio Grande do Sul (Brazil)

2016-03-15

Proper estimation of magnetization curve parameters is vital in studying magnetic systems. In the present article, criteria for discrimination non-saturated (minor) from saturated (major) hysteresis loops are proposed. These employ the analysis of (i) derivatives of both ascending and descending branches of the loop, (ii) remanent magnetization curves, and (iii) thermomagnetic curves. Computational simulations are used in order to demonstrate their validity. Examples illustrating the applicability of these criteria to well-known real systems, namely Fe{sub 3}O{sub 4} and Ni fine particles, are provided. We demonstrate that the anisotropy-field value estimated from a visual examination of an only apparently major hysteresis loop could be more than two times lower than the real one. - Highlights: • Proper estimation of hysteresis-loop parameters is vital in magnetic studies. • We propose criteria for discrimination minor from major hysteresis loops. • The criteria analyze magnetization, remanence and ZFC/FC curves and/or their derivatives. • Examples of their application on real nanoparticles systems are given. • Using the criteria could avoid twofold or bigger saturation-field underestimation errors.

45 CFR 1176.3 - Criteria.

Science.gov (United States)

2010-10-01

... ENDOWMENT FOR THE HUMANITIES PART-TIME CAREER EMPLOYMENT § 1176.3 Criteria. Positions becoming vacant... to part-time. Among the criteria which may be used when conducting this review are: (a) Mission...

The DSM diagnostic criteria for gender identity disorder in adolescents and adults.

Science.gov (United States)

Cohen-Kettenis, Peggy T; Pfäfflin, Friedemann

2010-04-01

Apart from some general issues related to the Gender Identity Disorder (GID) diagnosis, such as whether it should stay in the DSM-V or not, a number of problems specifically relate to the current criteria of the GID diagnosis for adolescents and adults. These problems concern the confusion caused by similarities and differences of the terms transsexualism and GID, the inability of the current criteria to capture the whole spectrum of gender variance phenomena, the potential risk of unnecessary physically invasive examinations to rule out intersex conditions (disorders of sex development), the necessity of the D criterion (distress and impairment), and the fact that the diagnosis still applies to those who already had hormonal and surgical treatment. If the diagnosis should not be deleted from the DSM, most of the criticism could be addressed in the DSM-V if the diagnosis would be renamed, the criteria would be adjusted in wording, and made more stringent. However, this would imply that the diagnosis would still be dichotomous and similar to earlier DSM versions. Another option is to follow a more dimensional approach, allowing for different degrees of gender dysphoria depending on the number of indicators. Considering the strong resistance against sexuality related specifiers, and the relative difficulty assessing sexual orientation in individuals pursuing hormonal and surgical interventions to change physical sex characteristics, it should be investigated whether other potentially relevant specifiers (e.g., onset age) are more appropriate.

10 CFR 905.36 - Marketing criteria.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Marketing criteria. 905.36 Section 905.36 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.36 Marketing criteria. Western shall retain applicable provisions of existing marketing criteria for projects where...

Wittgenstein's Contextualist Approach to Judging "Sound" Teaching: Escaping Enthrallment in Criteria-Based Assessments

Science.gov (United States)

Stickney, Jeff Alan

2009-01-01

Comparing the early, analytic attempt to define "sound" teaching with the current use of criteria-based rating schemes, Jeff Stickney turns to Wittgenstein's holistic, contextualist approach to judging teaching against its complex "background" within our "form of life." To exemplify this approach, Stickney presents cases of classroom practice…

Aluminum toxicity in dialysis patients: Radiographic findings and establishment of biopsy-sparing criteria

International Nuclear Information System (INIS)

Kriegshauser, J.S.; Swee, R.G.; McCarthy, J.T.; Hauser, M.F.

1986-01-01

Aluminum toxicity in dialysis patients currently requires bone biopsy for diagnosis. The authors retrospectively reviewed the findings in 63 dialysis patients who had undergone bone biopsies. In 30 patients biopsies were negative for aluminum toxicity and in 33 patients biopsies were positive. In 17 of the 30 biopsy-negative patients, absence of aluminum toxicity could be predicted by a high parathyroid hormone (iPTH) level (>200 μEq/ml) and fewer than three fractures, or by the presence of osteosclerosis on radiographs. No biopsy-positive patients met these criteria (P < .001). In 16 of 33 biopsy-positive patients aluminum toxicity could be predicted by a low iPTH level (<500 μEq/ml) and more than three fractures. No biopsy-negative patient met these criteria (P < .001). Thus, based on the criteria we have identified, 52.4% of the patients could have been spared biopsy

Developing metapopulation connectivity criteria from genetic and habitat data to recover the endangered Mexican wolf.

Science.gov (United States)

Carroll, Carlos; Fredrickson, Richard J; Lacy, Robert C

2014-02-01

Restoring connectivity between fragmented populations is an important tool for alleviating genetic threats to endangered species. Yet recovery plans typically lack quantitative criteria for ensuring such population connectivity. We demonstrate how models that integrate habitat, genetic, and demographic data can be used to develop connectivity criteria for the endangered Mexican wolf (Canis lupus baileyi), which is currently being restored to the wild from a captive population descended from 7 founders. We used population viability analysis that incorporated pedigree data to evaluate the relation between connectivity and persistence for a restored Mexican wolf metapopulation of 3 populations of equal size. Decreasing dispersal rates greatly increased extinction risk for small populations (0.5 genetically effective migrants per generation may be achievable via natural dispersal under current landscape conditions. When sufficient data are available, these methods allow planners to move beyond general aspirational connectivity goals or rules of thumb to develop objective and measurable connectivity criteria that more effectively support species recovery. The shift from simple connectivity rules of thumb to species-specific analyses parallels the previous shift from general minimum-viable-population thresholds to detailed viability modeling in endangered species recovery planning. © 2013 Society for Conservation Biology.

The strategic selecting criteria and performance by using the multiple criteria method

Directory of Open Access Journals (Sweden)

Lisa Y. Chen

2008-02-01

Full Text Available As the increasing competitive intensity in the current service market, organizational capabilities have been recognized as the importance of sustaining competitive advantage. The profitable growth for the firms has been fueled a need to systematically assess and renew the organization. The purpose of this study is to analyze the financial performance of the firms to create an effective evaluating structure for the Taiwan's service industry. This study utilized TOPSIS (technique for order preference by similarity to ideal solution method to evaluate the operating performance of 12 companies. TOPSIS is a multiple criteria decision making method to identify solutions from a finite set of alternatives based upon simultaneous minimization of distance from an ideal point and maximization of distance from a nadir point. By using this approach, this study measures the financial performance of firms through two aspects and ten indicators. The result indicated e-life had outstanding performance among the 12 retailers. The findings of this study provided managers to better understand their market position, competition, and profitability for future strategic planning and operational management.

User-Centric Multi-Criteria Information Retrieval

Science.gov (United States)

Wolfe, Shawn R.; Zhang, Yi

2009-01-01

Information retrieval models usually represent content only, and not other considerations, such as authority, cost, and recency. How could multiple criteria be utilized in information retrieval, and how would it affect the results? In our experiments, using multiple user-centric criteria always produced better results than a single criteria.

Establishment of Risk based microbiological criteria in the Nordic countries: A case study on Campylobacter in broiler meat

DEFF Research Database (Denmark)

Nauta, Maarten

Microbiological criteria (MCs) offer a practical tool for food safety control and they are currently under discussion internationally. To meet the present scientific standards, there is an increasing demand for so- called “risk based” microbiological criteria that are based on risk assessment....... In this project we studied the potentials for setting risk based microbiological criteria on Campylobacter in chicken meat by studying the potential impact that specific microbiological criteria would have in different Nordic countries. This is done on the basis of different data sets that have been collected...... based microbiological criteria, the “case-by-case” risk assessment methodology is used (Christensen et al 2013) and its impact is analysed on the basis of the same data sets. In both approaches the same risk assessment model for Campylobacter in broiler meat is used. The difference between...

Selection of response criteria for clinical trials of sarcoma treatment.

Science.gov (United States)

Schuetze, Scott M; Baker, Laurence H; Benjamin, Robert S; Canetta, Renzo

2008-01-01

Soft tissue sarcomas are a heterogeneous group of malignancies arising from mesenchymal tissues. A large number of new therapies are being evaluated in patients with sarcomas, and consensus criteria defining treatment responses are essential for comparison of results from studies completed by different research groups. The 1979 World Health Organization (WHO) handbook set forth operationally defined criteria for response evaluation in solid tumors that were updated in 2000 with the publication of the Response Evaluation Criteria in Solid Tumors (RECIST). There have been significant advances in tumor imaging, however, that are not reflected in the RECIST. For example, computed tomography (CT) slice thickness has been reduced from 10 mm to < or =2.5 mm, allowing for more reproducible and accurate measurement of smaller lesions. Combination of imaging techniques, such as positron emission tomography with fluorine-18-fluorodeoxyglucose (18FDG-PET) and CT can provide investigators and clinicians with both anatomical and functional information regarding tumors, and there is now a large body of evidence demonstrating the effectiveness of PET/CT and other newer imaging methods for the detection and staging of tumors as well as early determination of responses to therapy. The application of newer imaging methods has the potential to decrease both the sample sizes required for, and duration of, clinical trials by providing an early indication of therapeutic response that is well correlated with clinical outcomes, such as time to tumor progression or overall survival. The results summarized in this review support the conclusion that the RECIST and the WHO criteria for evaluation of response in solid tumors need to be modernized. In addition, there is a current need for prospective trials to compare new response criteria with established endpoints and to validate imaging-based response rates as surrogate endpoints for clinical trials of new agents for sarcoma and other solid

Guidelines for the development of natural phenomena hazards design criteria for surface facilities

International Nuclear Information System (INIS)

Nelson, T.A.; Hossain, Q.A.; Murray, R.C.

1992-01-01

This paper discusses the rationale behind the guidelines, criteria, and methodologies that are currently used for natural phenomena hazard design and evaluation of DOE nuclear and non-nuclear facilities. The bases for the performance goals and usage categories specified in UCRL-15910 are examined, and the sources of intentional conservatism in the analyses, design, and evaluation methods and criteria are identified. Outlines of recent developments/changes in DOE Orders related to Natural Phenomena hazard mitigation are also presented. Finally, the authors recommend the use of DOE methodologies as embodied in UCRL-15910 for design and evaluation of surface facilities of the high level nuclear waste repository site

The qTSN positive effect on panicle and flag leaf size of rice is associated with an early down-regulation of tillering

Directory of Open Access Journals (Sweden)

Dewi Erika eAdriani

2016-01-01

Full Text Available The qTSN4 was identified as rice QTL (Quantitative Traits Locus increasing total spikelet number per panicle and flag leaf area but potentially reducing panicle number depending on the environment. So far, this trade-off was mainly observed at grain maturity and not specifically studied in details, limiting the apprehension of the agronomic interest of qTSN4. This study aimed to understand the effect of qTSN4 and of the environment on panicle sizing, its trade-off with panicle number and finally plant grain production. It compared two high yielding genotypes to their Near Isogenic Lines (NIL carrying either QTL qTSN4 or qTSN12, two distinct QTLs contributing to the enlarged panicle size, thereafter designated as qTSN. Traits describing C sink (organ appearance rate, size, biomass and source (leaf area, photosynthesis, sugar availability were dynamically characterized along plant and/or panicle development within two trials (greenhouse, field, each comparing two treatments contrasting for plant access to light (with or without shading, high or low planting densities. The positive effect of qTSN on panicle size and flag leaf area of the main tiller was confirmed. More precisely, it could be shown that qTSN increased leaf area and internode cross-section, and in some cases of the photosynthetic rate and starch reserves, of the top 3-4 phytomers of the main tiller. This was accompanied by an earlier tillering cessation, that coincided with the initiation of these phytomers, and an enhanced of panicle size on the main tiller. Plant leaf area at flowering was not affected by qTSN but fertile tiller number was reduced to an extent that depended on the environment. Accordingly, plant grain production was enhanced by qTSN only under shading in the greenhouse experiment, where panicle number was not affected and photosynthesis and starch storage in internodes was enhanced. The effect of qTSN on rice phenotype was thus expressed before panicle initiation

Criteria for operator review of workplace changes

International Nuclear Information System (INIS)

Davey, E.

2000-01-01

A set of criteria for reviewing workplace changes has been developed for use by plant Operations staff. The criteria were developed to provide Operations staff with a practical framework for structuring assessments and subsequent review comments with regard to control room modifications and innovations that impact their work environment. The criteria were assembled from design, operations and human factors engineering principles, and system review experiences with plant Operations staff over the past ten years. Operations staff at several CANDU stations helped shape the emphasis for initial criteria definition and have assisted with criteria refinement through trial applications. Use of the criteria is expected to lead to more effective and task relevant equipment evaluations by Operations staff, and ultimately lead to system modifications and innovations that better serve plant operation needs. The paper begins with a discussion of the rationale for criteria development and the attributes of 'good' design. The balance of the paper outlines the project objectives, describes the approach applied in assembling, structuring, and refining the review criteria, and illustrates the application of the criteria in the review of a proposed control room innovation. (author)

Quality criteria for chest X-ray image

International Nuclear Information System (INIS)

Krieg, R.

1985-01-01

A distinction has to be made between invariable and variable criteria in the determination of chest X-ray picture quality criteria. The invariable criteria are defined by the properties of the object and the psychophysiological laws of perception and cognition, and the variable criteria are determined by the prevailing state of the art of technology. An agreement on these criteria is based on the knowledge of the nature and the technical conditions of X-ray picture production and reproduction. The slogan 'the best picture at the lowest dose' dominates, too, the discussion centering around the X-ray picture of the chest, its quality and criteria. (orig./MG) [de

[Effects of reduced solar radiation on winter wheat flag leaf net photosynthetic rate].

Science.gov (United States)

Zheng, You-Fei; Ni, Yan-Li; Mai, Bo-Ru; Wu, Rong-Jun; Feng, Yan; Sun, Jian; Li, Jian; Xu, Jing-Xin

2011-06-01

Taking winter wheat Triticum aestivum L. (cv. Yangmai 13) as test material, a field experiment was conducted in Nanjing City to study the effects of simulated reduced solar radiation on the diurnal variation of winter wheat flag leaf photosynthetic rate and the main affecting factors. Five treatments were installed, i. e., 15% (T15), 20% (T20) , 40% (T40), 60% (T60), and 100% (CK) of total incident solar radiation. Reduced solar irradiance increased the chlorophyll and lutein contents significantly, but decreased the net photosynthetic rate (Pn). Under different solar irradiance, the diurnal variation of Pn had greater difference, and the daily maximum Pn was in the order of CK > T60 > T40 > T 20 > T15. In CK, the Pn exhibited a double peak diurnal curve; while in the other four treatments, the Pn showed a single peak curve, and the peak was lagged behind that of CK. Correlation analysis showed that reduced solar irradiance was the main factor affecting the diurnal variation of Pn, but the physiological parameters also played important roles in determining the diurnal variation of Pn. In treatments T60 and T40, the photosynthesis active radiation (PAR), leaf temperature (T1) , stomatal conductance (Gs) , and transpiration rate (Tr) were significantly positively correlated with Pn, suggesting their positive effects on Pn. The intercellular CO2 concentration (Ci) and stomatal limitation (Ls) had significant negative correlations with Pn in treatments T60 and T40 but significant positive correlations with Pn in treatments T20 and T15, implying that the Ci and Ls had negative (or positive) effects on Pn when the solar irradiance was higher (or lower) than 40% of incident solar irradiance.

Assessing health status and quality-of-life instruments: attributes and review criteria.

Science.gov (United States)

Aaronson, Neil; Alonso, Jordi; Burnam, Audrey; Lohr, Kathleen N; Patrick, Donald L; Perrin, Edward; Stein, Ruth E

2002-05-01

The field of health status and quality of life (QoL) measurement - as a formal discipline with a cohesive theoretical framework, accepted methods, and diverse applications--has been evolving for the better part of 30 years. To identify health status and QoL instruments and review them against rigorous criteria as a precursor to creating an instrument library for later dissemination, the Medical Outcomes Trust in 1994 created an independently functioning Scientific Advisory Committee (SAC). In the mid-1990s, the SAC defined a set of attributes and criteria to carry out instrument assessments; 5 years later, it updated and revised these materials to take account of the expanding theories and technologies upon which such instruments were being developed. This paper offers the SAC's current conceptualization of eight key attributes of health status and QoL instruments (i.e., conceptual and measurement model; reliability; validity; responsiveness; interpretability; respondent and administrative burden; alternate forms; and cultural and language adaptations) and the criteria by which instruments would be reviewed on each of those attributes. These are suggested guidelines for the field to consider and debate; as measurement techniques become both more familiar and more sophisticated, we expect that experts will wish to update and refine these criteria accordingly.

Members of the barley NAC transcription factor gene family show differential co-regulation with senescence-associated genes during senescence of flag leaves

DEFF Research Database (Denmark)

Christiansen, Michael W; Gregersen, Per L.

2014-01-01

-expressed with members of the NAC gene family. In conclusion, a list of up to 15 NAC genes from barley that are strong candidates for being regulatory factors of importance for senescence and biotic stress-related traits affecting the productivity of cereal crop plants has been generated. Furthermore, a list of 71...... in the NAC transcription factor family during senescence of barley flag leaves was studied. Several members of the NAC transcription factor gene family were up-regulated during senescence in a microarray experiment, together with a large range of senescence-associated genes, reflecting the coordinated...... activation of degradation processes in senescing barley leaf tissues. This picture was confirmed in a detailed quantitative reverse transcription–PCR (qRT–PCR) experiment, which also showed distinct gene expression patterns for different members of the NAC gene family, suggesting a group of ~15 out of the 47...

CCS site characterisation criteria

Energy Technology Data Exchange (ETDEWEB)

Bachu, S.; Hawkes, C.; Lawton, D.; Pooladi-Darvish, M.; Perkins, E.

2009-12-15

IEA GHG recently commissioned the Alberta Research Counil in Canada to conduct a review of storage site selection criteria and site characterisation methods in order to produce a synthesis report. This report reviews the literature on the subject on the site seleciton and characterisation since the publication of the IPCC Special Report on CCS, and provides a synthesis and classification of criteria. 161 refs.

Risk assessment of soil contamination criteria

International Nuclear Information System (INIS)

King, C.M.; Marter, W.L.; Montaque, D.F.; Holton, G.A.

1987-06-01

Criteria have been developed to select radioactive and nonradioactive contaminants at waste sites detailed analysis and risk assessment. These criteria were based on soil and water quality guidelines developed by various government agencies to determine if the criteria were appropriate. We performed a risk assessment of a hypothetical site which contained radioactive and nonradioactive contaminants at levels equal to the criteria values. Risks to the public from atmospheric, surface water, and groundwater exposure pathways were examined. Health risks to the public from atmospheric releases of radioactive and nonradioactive materials from a waste at soil criteria contamination levels are low. Health risks to the maximally exposed individual to chemical carcinogens are considerably below traditional EPA action levels. And health risks to the maximally exposed individual to atmospherically released radioactive contaminants is 1.88 x 10 -7 , more than a factor of 5 less than 10 -6 . Based on our atmospheric exposure pathways analysis and risk assessment, the applied soil criteria are appropriate for screening out unimportant risk contributors to human health from atmospheric exposure pathways. 13 refs., 3 figs., 7 tabs

NSSS supplier's response to differing safety criteria

Energy Technology Data Exchange (ETDEWEB)

Cremades, J; Filkin, R; Franke, T [Westinghouse Electric Nuclear Energy Systems Europe (WENESE), Brussels (Belgium)

1980-11-01

The limited progress achieved to date in harmonizing national criteria has led to the development of designs which include the most common national requirements. Progress towards harmonization of safety criteria can be accelerated by expanding the IAEA leadership and co-ordination activities, and implementing an integrated approach to criteria development. National and International safety criteria are examined.

Proposed diagnostic criteria for internet addiction.

Science.gov (United States)

Tao, Ran; Huang, Xiuqin; Wang, Jinan; Zhang, Huimin; Zhang, Ying; Li, Mengchen

2010-03-01

The objective of this study was to develop diagnostic criteria for internet addiction disorder (IAD) and to evaluate the validity of our proposed diagnostic criteria for discriminating non-dependent from dependent internet use in the general population. This study was conducted in three stages: the developmental stage (110 subjects in the survey group; 408 subjects in the training group), where items of the proposed diagnostic criteria were developed and tested; the validation stage (n = 405), where the proposed criteria were evaluated for criterion-related validity; and the clinical stage (n = 150), where the criteria and the global clinical impression of IAD were evaluated by more than one psychiatrist to determine inter-rater reliability. The proposed internet addiction diagnostic criteria consisted of symptom criterion (seven clinical symptoms of IAD), clinically significant impairment criterion (functional and psychosocial impairments), course criterion (duration of addiction lasting at least 3 months, with at least 6 hours of non-essential internet usage per day) and exclusion criterion (exclusion of dependency attributed to psychotic disorders). A diagnostic score of 2 + 1, where the first two symptoms (preoccupation and withdrawal symptoms) and at least one of the five other symptoms (tolerance, lack of control, continued excessive use despite knowledge of negative effects/affects, loss of interests excluding internet, and use of the internet to escape or relieve a dysphoric mood) was established. Inter-rater reliability was 98%. Our findings suggest that the proposed diagnostic criteria may be useful for the standardization of diagnostic criteria for IAD.

International comparison of safety criteria applied to radwaste repositories. Safety aspects of the post-operational phase

International Nuclear Information System (INIS)

Baltes, B.

1994-01-01

There is a generally accepted system of framework safety conditions governing the construction, operation, and post-operational monitoring of radwaste repositories. Although the development of these framework conditions may vary from country to country, the resulting criteria are based on the commonly accepted system of priciples and purposes established for ultimate radioactive waste disposal. The experience accumulated by GRS in the course of the plan approval procedure for the Konrad mine site and the safety-relevant studies performed for the planned Morsleben repository clearly show demand for further development of the safety criteria. In Germany, it is especially the safety criteria and detailed requirements filling the framework safety conditions that need revision and in-depth definition, as well as comparison and harmonisation with internationally applied criteria. These activities will particularly consider the international convention on radioactive waste management currently in preparation under the auspieces of the IAEA. (orig.) [de

Potentially inappropriate prescribing in institutionalised older patients in Spain: the STOPP-START criteria compared with the Beers criteria

Directory of Open Access Journals (Sweden)

Bonet M

2012-06-01

Full Text Available Objective: The aims of this study were to identify potentially inappropriate prescribing using the Beers and STOPP criteria. The START criteria were applied to detect prescription omission in the geriatric population. We compared the utility of these criteria in institutionalised older people.Methods: Descriptive study reviewing the medication and clinical records of 81 residents (aged 65 years and more by pharmacists in a nursing home in the Lleida region (Spain.Results: The mean patients’ age was 84 (SD=8 years, with an average of 5 drugs per resident (total prescriptions: 416 medicines. The Beers criteria identified potentially inappropriate medication use in 25% of patients and 48% of patients used at least 1 inappropriate medication according to STOPP criteria. The most frequent potentially inappropriate medications for both criteria were long-acting benzodiazepines and NSAIDs. START detected 58 potential prescribing omissions in 44% of patients. Calcium-vitamin D supplementation in osteoporosis was the most frequent rule (15%, but omissions corresponding to the cardiovascular system implied 23% of patients.Conclusion: The STOPP-START criteria reveal that potentially inappropriate prescribing (PIP is a highly prevalent problem among Spanish nursing home residents, and a statistically significant positive correlation was found between the number of medicines prescribed and the number of PIP detected in this study. The STOPP criteria detect a larger number of PI medications in this geriatric population than the Beers criteria. The prescribing omissions detected by the START criteria are relevant and require intervention. Pharmacists’ review of medications may help identify potentially inappropriate prescribing and, through an interdisciplinary approach, working with physicians may improve prescribing practices among geriatric residents of nursing homes.

Multi-criteria decision making approaches for quality control of genome-wide association studies.

Science.gov (United States)

Malovini, Alberto; Rognoni, Carla; Puca, Annibale; Bellazzi, Riccardo

2009-03-01

Experimental errors in the genotyping phases of a Genome-Wide Association Study (GWAS) can lead to false positive findings and to spurious associations. An appropriate quality control phase could minimize the effects of this kind of errors. Several filtering criteria can be used to perform quality control. Currently, no formal methods have been proposed for taking into account at the same time these criteria and the experimenter's preferences. In this paper we propose two strategies for setting appropriate genotyping rate thresholds for GWAS quality control. These two approaches are based on the Multi-Criteria Decision Making theory. We have applied our method on a real dataset composed by 734 individuals affected by Arterial Hypertension (AH) and 486 nonagenarians without history of AH. The proposed strategies appear to deal with GWAS quality control in a sound way, as they lead to rationalize and make explicit the experimenter's choices thus providing more reproducible results.

Fostering and Assessing Infographic Design for Learning: The Development of Infographic Design Criteria

Science.gov (United States)

Nuhoglu Kibar, Pinar; Akkoyunlu, Buket

2017-01-01

In this ever more digital and visual world, it has become more vital that students are encouraged to create content during the learning process through effective visualization of their knowledge. Infographics are an effective method for such visualization. The current study therefore proposes an infographic design rubric (IDR) as a criteria-based…

Volumetry of metastases from renal cell carcinoma. Comparison with the RECIST criteria

International Nuclear Information System (INIS)

Graser, A.; Becker, C.R.; Reiser, M.F.; Stief, C.; Staehler, M.

2008-01-01

For patients with metastasized renal cell carcinoma (RCC), imaging techniques are of great importance. Currently, therapy widely relies on antiangiogenic factors, which frequently lead to relatively subtle changes in the size of lesions. From this aspect the commonly used RECIST criteria (response evaluation criteria in solid tumors) must be considered as imprecise for the evaluation of the response to therapy. This article gives a review on new software-based volumetric methods, which allow therapy-induced changes in the size of metastases from RCC to be detected with higher sensitivity and reproducibility. A comparison of RECIST and volumetry was carried out with data from patients with metastasized RCC to demonstrate the higher sensitivity of the 3D volumetric procedure. (orig.) [de

High level waste repository site suitability criteria. Environmental impact statement methodology

International Nuclear Information System (INIS)

1977-06-01

The approach (methodology) which has been developed for the preparation of the environmental impact statement (EIS) is described. A suggested outline is presented for the High Level Waste Repository Site Suitability Criteria EIS together with a detailed description of the approach to be used in preparing the EIS. In addition, a methodology is presented by which the necessary cost/benefit/risk comparisons of alternative sets of site suitability criteria can be made. The TERA environmental research data bank, a computerized data bank which contained information on current and historical licensing activities for power plants was modified to include information on generic or programmatic EIS related issues. The content of the modified data bank was utilized to develop the EIS outline presented in this report. The report recommends that a modified matrix evaluation approach be used to make the cost/benefit/risk comparisons. The suggested matrix is designed to facilitate between criteria comparative analyses of economic, environmental, sociological and radiological risk factors. The quantitative compositing of dollar cost and benefits, environmental and sociological impacts, and radiological risks is to be performed using a semi-analytical, semi-visual procedure based on the concept of ''decision surfaces.''

Validity of proposed DSM-5 diagnostic criteria for nicotine use disorder: results from 734 Israeli lifetime smokers

Science.gov (United States)

Shmulewitz, D.; Wall, M.M.; Aharonovich, E.; Spivak, B.; Weizman, A.; Frisch, A.; Grant, B. F.; Hasin, D.

2013-01-01

Background The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) proposes aligning nicotine use disorder (NUD) criteria with those for other substances, by including the current DSM fourth edition (DSM-IV) nicotine dependence (ND) criteria, three abuse criteria (neglect roles, hazardous use, interpersonal problems) and craving. Although NUD criteria indicate one latent trait, evidence is lacking on: (1) validity of each criterion; (2) validity of the criteria as a set; (3) comparative validity between DSM-5 NUD and DSM-IV ND criterion sets; and (4) NUD prevalence. Method Nicotine criteria (DSM-IV ND, abuse and craving) and external validators (e.g. smoking soon after awakening, number of cigarettes per day) were assessed with a structured interview in 734 lifetime smokers from an Israeli household sample. Regression analysis evaluated the association between validators and each criterion. Receiver operating characteristic analysis assessed the association of the validators with the DSM-5 NUD set (number of criteria endorsed) and tested whether DSM-5 or DSM-IV provided the most discriminating criterion set. Changes in prevalence were examined. Results Each DSM-5 NUD criterion was significantly associated with the validators, with strength of associations similar across the criteria. As a set, DSM-5 criteria were significantly associated with the validators, were significantly more discriminating than DSM-IV ND criteria, and led to increased prevalence of binary NUD (two or more criteria) over ND. Conclusions All findings address previous concerns about the DSM-IV nicotine diagnosis and its criteria and support the proposed changes for DSM-5 NUD, which should result in improved diagnosis of nicotine disorders. PMID:23312475

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Diagnostic Task Force Criteria Impact of New Task Force Criteria

NARCIS (Netherlands)

Cox, Moniek G. P. J.; van der Smagt, Jasper J.; Noorman, Maartje; Wiesfeld, Ans C.; Volders, Paul G. A.; van Langen, Irene M.; Atsma, Douwe E.; Dooijes, Dennis; Houweling, Arjan C.; Loh, Peter; Jordaens, Luc; Arens, Yvonne; Cramer, Maarten J.; Doevendans, Pieter A.; van Tintelen, Peter; Wilde, Arthur A. M.; Hauer, Richard N. W.

Background-Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) Diagnostic Task Force Criteria (TFC) proposed in 1994 are highly specific but lack sensitivity. A new international task force modified criteria to improve diagnostic yield. A comparison of diagnosis by 1994 TFC versus

Controllable unit concept as applied to a hypothetical tritium process

International Nuclear Information System (INIS)

Seabaugh, P.W.; Sellers, D.E.; Woltermann, H.A.; Boh, D.R.; Miles, J.C.; Fushimi, F.C.

1976-01-01

A methodology (controllable unit accountability) is described that identifies controlling errors for corrective action, locates areas and time frames of suspected diversions, defines time and sensitivity limits of diversion flags, defines the time frame in which pass-through quantities of accountable material and by inference SNM remain controllable and provides a basis for identification of incremental cost associated with purely safeguards considerations. The concept provides a rationale from which measurement variability and specific safeguard criteria can be converted into a numerical value that represents the degree of control or improvement attainable with a specific measurement system or combination of systems. Currently the methodology is being applied to a high-throughput, mixed-oxide fuel fabrication process. The process described is merely used to illustrate a procedure that can be applied to other more pertinent processes

OSCILLATION CRITERIA FOR FORCED SUPERLINEAR DIFFERENCE EQUATIONS

Institute of Scientific and Technical Information of China (English)

无

2008-01-01

Using Riccati transformation techniques,some oscillation criteria for the forced second-order superlinear difference equations are established.These criteria are dis- crete analogues of the criteria for differential equations proposed by Yan.

Characteristics of output voltage and current of integrated nanogenerators

KAUST Repository

Yang, Rusen; Qin, Yong; Li, Cheng; Dai, Liming; Wang, Zhong Lin

2009-01-01

three criteria: Schottky behavior test, switching-polarity tests, and linear superposition of current and voltage tests. The 11 tests can effectively rule out the system artifacts, whose sign does not change with the switching measurement polarity

Establishing endangered species recovery criteria using predictive simulation modeling

Science.gov (United States)

McGowan, Conor P.; Catlin, Daniel H.; Shaffer, Terry L.; Gratto-Trevor, Cheri L.; Aron, Carol

2014-01-01

Listing a species under the Endangered Species Act (ESA) and developing a recovery plan requires U.S. Fish and Wildlife Service to establish specific and measurable criteria for delisting. Generally, species are listed because they face (or are perceived to face) elevated risk of extinction due to issues such as habitat loss, invasive species, or other factors. Recovery plans identify recovery criteria that reduce extinction risk to an acceptable level. It logically follows that the recovery criteria, the defined conditions for removing a species from ESA protections, need to be closely related to extinction risk. Extinction probability is a population parameter estimated with a model that uses current demographic information to project the population into the future over a number of replicates, calculating the proportion of replicated populations that go extinct. We simulated extinction probabilities of piping plovers in the Great Plains and estimated the relationship between extinction probability and various demographic parameters. We tested the fit of regression models linking initial abundance, productivity, or population growth rate to extinction risk, and then, using the regression parameter estimates, determined the conditions required to reduce extinction probability to some pre-defined acceptable threshold. Binomial regression models with mean population growth rate and the natural log of initial abundance were the best predictors of extinction probability 50 years into the future. For example, based on our regression models, an initial abundance of approximately 2400 females with an expected mean population growth rate of 1.0 will limit extinction risk for piping plovers in the Great Plains to less than 0.048. Our method provides a straightforward way of developing specific and measurable recovery criteria linked directly to the core issue of extinction risk. Published by Elsevier Ltd.

The Investigation of the Effectiveness of the Criteria for the Construction of a Physics Text for Students with Dyslexia: The Case of the Electric Current

Science.gov (United States)

Papalexopoulos, Panagiotis F.; Vavougios, Dionisios; Vlachos, Filippos; Karapetsas, Argiris B.

2008-01-01

In this paper we studied the effectiveness of the writing criteria that are proposed to be applied during the construction of physics texts so that students with dyslexia do not confront reading difficulties with them. The effectiveness of the criteria has been assessed by the accomplishment of an investigation among students with and without…

Site characterization criteria (DOE-STD-1022-94) for natural phenomena hazards at DOE sites. Revision 1

International Nuclear Information System (INIS)

Chen, J.C.; Ueng, Tzou-Shin; Boissonnade, A.C.

1995-01-01

This paper briefly summarizes requirements of site characterization for Natural Phenomena Hazards (NPH) at DOE sites. In order to comply with DOE Order 5480.28, site characterization criteria has been developed to provide site-specific information needed for development of NPH assessment criteria. Appropriate approaches are outlined to ensure that the current state-of-the-art methodologies and procedures are used in the site characterization. General and detailed site characterization requirements are provided in the areas of meteorology, hydrology, geology, seismology and geotechnical studies

Principles and Criteria for Design

DEFF Research Database (Denmark)

Beghin, D.; Cervetto, D.; Hansen, Peter Friis

1997-01-01

The mandate of ISSC Committee IV.1 on principles and Criteria for Design is to report on the following:The ongoing concern for quantification of general economic and safety criteria for marine structures and for the development of appropriate principles for rational life cycle design using...

Diagnostic criteria for vascular dementia

NARCIS (Netherlands)

Scheltens, P.; Hijdra, A. H.

1998-01-01

The term vascular dementia implies the presence of a clinical syndrome (dementia) caused by, or at least assumed to be caused by, a specific disorder (cerebrovascular disease). In this review, the various sets of criteria used to define vascular dementia are outlined. The various sets of criteria

Optimization of power plants management structure based on the generalized criteria of the efficiency

Directory of Open Access Journals (Sweden)

Salov Aleksey

2017-01-01

Full Text Available In the article, the analysis of the operation of power plants in the conditions of economic restructuring to ensure successful entry into the market is carried out. The analysis of the five management structures, including current, typical structure and re-designed by the authors is presented. There are developed the partial efficiency criteria of the management structures that characterize the most important properties - the balance, integrity, controllability and stability. Local criteria of the analyzed structures do not allow to make a definite conclusion about the effectiveness of one of the structures analyzed, formulated global efficiency criterion. There is developed the global criterion of the comparative effectiveness of the management systems based on the DEA method (Data envelopment analysis, taking into account the complex of the proposed local criteria. The considered management structures are ranked based on the generalized criterion of efficiency.

Recommended criteria for the evaluation of on-site nuclear power plant emergency plans, volume II: criteria

International Nuclear Information System (INIS)

1997-01-01

A critical review of existing Canadian and international nuclear power plant (NPP) emergency plans, evaluation criteria, and approaches has been conducted to provide AECB staff with information which can be used to assess the adequacy of NPP on-site emergency response plans. The results of this work are published in two volumes. Volume I, Basis Document, provides the reasons why certain requirements are in place. It also gives comprehensive references to various standards.Volume II, Criteria, contains the criteria which relate to on-site actions and their integration with control room activities and the roles of off-site responsible organizations. The recommended criteria provide information on what is required, and not on how to accomplish the requirements. The licensees are given the latitude to decide on the methods and processes needed to meet the requirements. The documents do not address NPP off-site plans and response capability, or the control room emergency operating procedures and response capability. This report contains only Volume II: Criteria. 55 refs., 2 tabs., 1 fig

Social Advertising Quality: Assessment Criteria

Directory of Open Access Journals (Sweden)

S. B. Kalmykov

2017-01-01

Full Text Available Purpose: the The purpose of the publication is development of existing criterial assessment in social advertising sphere. The next objectives are provided for its achievement: to establish research methodology, to develop the author’s version of necessary notional apparatus and conceptual generalization, to determine the elements of social advertising quality, to establish the factors of its quality, to conduct the systematization of existing criteria and measuring instruments of quality assessment, to form new criteria of social advertising quality, to apply received results for development of criterial assessment to determine the further research perspectives. Methods: the methodology of research of management of social advertising interaction with target audience, which has dynamic procedural character with use of sociological knowledge multivariate paradigmatic status, has been proposed. Results: the primary received results: the multivariate paradigmatic research basis with use of works of famous domestic and foreign scientists in sociology, qualimetry and management spheres; the definitions of social advertising, its quality, sociological quality provision system, target audience behavior model during social advertising interaction are offered; the quality factors with three groups by level of effect on consumer are established; the systematization of existing quality and its measure instruments assessment criteria by detected social advertising quality elements are conducted; the two new criteria and its management quality assessment measuring instruments in social advertising sphere are developed; the one of the common groups of production quality criteria – adaptability with considering of new management quality criteria and conducted systematization of existing social advertising creative quality assessment criteria development; the perspective of further perfection of quality criterial assessment based on social advertising

Marines in the Boxer Rebellion as a Model for Current Marine Corps Operations

Science.gov (United States)

2016-06-10

landed in New Providence, Bahamas in 1778, raising the American flag for the first time on foreign soil .2 Years later, First Lieutenant Presley O’Bannon...Marines conducted landings (and in some cases multiple landings) in support of American interests in the Hawaiian Islands, Egypt, Colombia , Haiti, Samoa...Argentina, Chile, Nicaragua, Colombia , and Trinidad. Most instances centered on insurgent forces unwilling to accept

Comparing Symptoms of Autism Spectrum Disorders Using the Current "DSM-IV-TR" Diagnostic Criteria and the Proposed "DSM-V" Diagnostic Criteria

Science.gov (United States)

Worley, Julie A.; Matson, Johnny L.

2012-01-01

The American Psychiatric Association has proposed major revisions for the diagnostic category encompassing Autism Spectrum Disorders (ASD), which will reportedly increase the specificity and maintain the sensitivity of diagnoses. As a result, the aim of the current study was to compare symptoms of ASD in children and adolescents (N = 208) who met…

Ontological Realism for the Research Domain Criteria for Mental Disorders.

Science.gov (United States)

Ceusters, Werner; Jensen, Mark; Diehl, Alexander D

2017-01-01

At the heart of the Research Domain Criteria for Mental Disorders is a matrix in which functional aspects of behavior are related to genotypic and (endo-)phenotypic research findings, and the various techniques through which they can been observed. The matrix is work in progress. As such it currently suffers from several shortcomings, the resolution of which, we contend, are essential to success of NIMH's goal of fostering translational science on mental disorders. Using well-established criteria for assessing the terminological and ontological quality of biomedical representations we identified the major problems to be (1) the abundant presence of terms that lack face value, (2) the absence of what the exact nature of the represented relationships are, and (3) referential imprecision with respect to the intended granularity of what the terms denote. We propose to eliminate these shortcomings by resorting to definitions and formal representations under the umbrella of Ontological Realism as they already have been developed in the areas of mental health, anatomy and biological functions.

Opioid-use disorder among patients on long-term opioid therapy: impact of final DSM-5 diagnostic criteria on prevalence and correlates.

Science.gov (United States)

Boscarino, Joseph A; Hoffman, Stuart N; Han, John J

2015-01-01

Previously, we estimated the prevalence and risk factors for prescription opioid-use disorder among outpatients on opioid therapy using the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 and DSM-4 criteria. However, at the time, the DSM-5 criteria were not finalized. In the current study, we analyzed these data using the final DSM-5 criteria and compared these results. Using electronic records from a large US health care system, we identified outpatients receiving five or more prescription orders for opioid therapy in the past 12 months for noncancer pain (mean prescription orders =10.72; standard deviation =4.96). In 2008, we completed diagnostic interviews with 705 of these patients using the DSM-4 criteria. In the current study, we reassessed these results using the final DSM-5 criteria. The lifetime prevalence of DSM-5 opioid-use disorders using the final DSM-5 criteria was 58.7% for no or few symptoms (DSM-4 criteria indicated that the majority of patients with lifetime DSM-4 opioid dependence were now classified as having mild opioid-use disorder, based on the DSM-5 criteria (53.6%; 95% CI =44.1-62.8). In ordinal logistic regression predicting no/few, mild, moderate, and severe opioid-use disorder, the best predictors were age DSM-5 criteria, including the elimination of tolerance and withdrawal, inclusion of craving and abuse symptoms, and introduction of a new graded severity classification, the prevalence of opioid-use disorders has changed, while many of the DSM-4 risk factors for opioid dependence were similar. To our knowledge, this is one of the first studies to compare the final results for DSM-5 versus DSM-4 prescription opioid-use disorders among a high-risk patient population.

Evolving fuzzy rules for relaxed-criteria negotiation.

Science.gov (United States)

Sim, Kwang Mong

2008-12-01

In the literature on automated negotiation, very few negotiation agents are designed with the flexibility to slightly relax their negotiation criteria to reach a consensus more rapidly and with more certainty. Furthermore, these relaxed-criteria negotiation agents were not equipped with the ability to enhance their performance by learning and evolving their relaxed-criteria negotiation rules. The impetus of this work is designing market-driven negotiation agents (MDAs) that not only have the flexibility of relaxing bargaining criteria using fuzzy rules, but can also evolve their structures by learning new relaxed-criteria fuzzy rules to improve their negotiation outcomes as they participate in negotiations in more e-markets. To this end, an evolutionary algorithm for adapting and evolving relaxed-criteria fuzzy rules was developed. Implementing the idea in a testbed, two kinds of experiments for evaluating and comparing EvEMDAs (MDAs with relaxed-criteria rules that are evolved using the evolutionary algorithm) and EMDAs (MDAs with relaxed-criteria rules that are manually constructed) were carried out through stochastic simulations. Empirical results show that: 1) EvEMDAs generally outperformed EMDAs in different types of e-markets and 2) the negotiation outcomes of EvEMDAs generally improved as they negotiated in more e-markets.

First Update of the Criteria for Certification of Chest Pain Units in Germany: Facelift or New Model?

Science.gov (United States)

Breuckmann, Frank; Rassaf, Tienush

2016-03-01

In an effort to provide a systematic and specific standard-of-care for patients with acute chest pain, the German Cardiac Society introduced criteria for certification of specialized chest pain units (CPUs) in 2008, which have been replaced by a recent update published in 2015. We reviewed the development of CPU establishment in Germany during the past 7 years and compared and commented the current update of the certification criteria. As of October 2015, 228 CPUs in Germany have been successfully certified by the German Cardiac Society; 300 CPUs are needed for full coverage closing gaps in rural regions. Current changes of the criteria mainly affect guideline-adherent adaptions of diagnostic work-ups, therapeutic strategies, risk stratification, in-hospital timing and education, and quality measures, whereas the overall structure remained unchanged. Benchmarking by participation within the German CPU registry is encouraged. Even though the history is short, the concept of certified CPUs in Germany is accepted and successful underlined by its recent implementation in national and international guidelines. First registry data demonstrated a high standard of quality-of-care. The current update provides rational adaptions to new guidelines and developments without raising the level for successful certifications. A periodic release of fast-track updates with shorter time frames and an increase of minimum requirements should be considered.

Development of criteria for release of Idaho National Engineering Laboratory sites following decontamination and decommissioning

International Nuclear Information System (INIS)

Kirol, L.

1986-08-01

Criteria have been developed for release of Idaho National Engineering Laboratory (INEL) facilities and land areas following decontamination and decommissioning (D and D). Although these facilities and land areas are not currently being returned to the public domain, and no plans exist for doing so, criteria suitable for unrestricted release to the public were desired. Midway through this study, the implementation of Department of Energy (DOE) Order 5820.2, Radioactive Waste Management, required development of site specific release criteria for use on D and D projects. These criteria will help prevent remedial actions from being required if INEL reuse considerations change in the future. Development of criteria for release of INEL facilities following D and D comprised four study areas: pathways analysis, dose and concentration guidelines, sampling and instrumentation, and implementation procedures. Because of the complex and sensitive nature of the first three categories, a thorough review by experts in those respective fields was desired. Input and support in preparing or reviewing each part of the criteria development task was solicited from several DOE field offices. Experts were identified and contracted to assist in preparing portions of the release criteria, or to serve on a peer-review committee. Thus, the entire release criteria development task was thoroughly reviewed by recognized experts from contractors at several DOE field offices, to validate technical content of the document. Each of the above four study areas was developed originally as an individual task, and a report was generated from each. These reports are combined here to form this document. This release criteria document includes INEL-specific pathways analysis, instrumentation requirements, sampling procedures, the basis for selection of dose and concentration guidelines, and cost-risk-benefit procedures

Summarized water quality criteria

International Nuclear Information System (INIS)

Kempster, P.L.; Hattingh, W.H.J.; Van Vliet, H.R.

1980-08-01

The available world literature from 27 sources on existing water quality criteria are summarized for the 15 main uses of water. The minimum, median and maximum specified values for 96 different determinands are included. Under each water use the criteria are grouped according to the functional significance of the determinands e.g. aesthetic/physical effects, high toxic potential, low toxic potential etc. A synopsis is included summarizing salient facts for each determinand such as the conditions under which it is toxic and its relationship to other determinands. The significance of the criteria is briefly discussed and the importance of considering functional interactions between determinands emphasized in evaluating the potential for toxic or beneficial effects. From the source literature it appears that the toxic potential, in addition to being determined by concentration, is also affected by the origin of the substance concerned, i.e. whether from natural sources or from anthropogenic pollution

A new approach to criteria for health risk assessment

International Nuclear Information System (INIS)

Spickett, Jeffery; Katscherian, Dianne; Goh, Yang Miang

2012-01-01

Health Impact Assessment (HIA) is a developing component of the overall impact assessment process and as such needs access to procedures that can enable more consistent approaches to the stepwise process that is now generally accepted in both EIA and HIA. The guidelines developed during this project provide a structured process, based on risk assessment procedures which use consequences and likelihood, as a way of ranking risks to adverse health outcomes from activities subjected to HIA or HIA as part of EIA. The aim is to assess the potential for both acute and chronic health outcomes. The consequences component also identifies a series of consequences for the health care system, depicted as expressions of financial expenditure and the capacity of the health system. These more specific health risk assessment characteristics should provide for a broader consideration of health consequences and a more consistent estimation of the adverse health risks of a proposed development at both the scoping and risk assessment stages of the HIA process. - Highlights: ► A more objective approach to health risk assessment is provided. ► An objective set of criteria for the consequences for chronic and acute impacts. ► An objective set of criteria for the consequences on the health care system. ► An objective set of criteria for event frequency that could impact on health. ► The approach presented is currently being trialled in Australia.

Opioid-use disorder among patients on long-term opioid therapy: impact of final DSM-5 diagnostic criteria on prevalence and correlates

Science.gov (United States)

Boscarino, Joseph A; Hoffman, Stuart N; Han, John J

2015-01-01

Aims Previously, we estimated the prevalence and risk factors for prescription opioid-use disorder among outpatients on opioid therapy using the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 and DSM-4 criteria. However, at the time, the DSM-5 criteria were not finalized. In the current study, we analyzed these data using the final DSM-5 criteria and compared these results. Methods Using electronic records from a large US health care system, we identified outpatients receiving five or more prescription orders for opioid therapy in the past 12 months for noncancer pain (mean prescription orders =10.72; standard deviation =4.96). In 2008, we completed diagnostic interviews with 705 of these patients using the DSM-4 criteria. In the current study, we reassessed these results using the final DSM-5 criteria. Results The lifetime prevalence of DSM-5 opioid-use disorders using the final DSM-5 criteria was 58.7% for no or few symptoms (DSM-5 criteria (53.6%; 95% CI =44.1–62.8). In ordinal logistic regression predicting no/few, mild, moderate, and severe opioid-use disorder, the best predictors were age DSM-5 criteria, including the elimination of tolerance and withdrawal, inclusion of craving and abuse symptoms, and introduction of a new graded severity classification, the prevalence of opioid-use disorders has changed, while many of the DSM-4 risk factors for opioid dependence were similar. To our knowledge, this is one of the first studies to compare the final results for DSM-5 versus DSM-4 prescription opioid-use disorders among a high-risk patient population. PMID:26316838

NWTS program criteria for mined geologic disposal of nuclear waste: program objectives, functional requirements, and system performance criteria

International Nuclear Information System (INIS)

1982-03-01

The NWTS-33 series, of which this document is a part, provides guidance for the National Waste Terminal Storage (NWTS) program in the development and implementation of licensed mined geologic disposal systems for solidified high-level and TRU wastes. Program objectives, functional requirements, and system performance criteria are found in this document. At the present time final criteria have not been issued by the Nuclear Regulatory Commission (NRC) and Environmental Protection Agency (EPA). The criteria in these documents have been developed on the basis of DOE's judgment of what is required to protect the health and safety of the public and the quality of the environment. It is expected that these criteria will be consistent with regulatory standards. The criteria will be re-evaluated on a periodic basis to ensure that they remain consistent with national waste management policy and regulatory requirements. A re-evaluation will be made when final criteria are promulgated by the NRC and EPA. A background section that briefly describes the mined geologic disposal system and explains the hierarchy and application of the NWTS criteria is included in Section 2.0. Secton 3.0 presents the program objectives, Section 4.0 functional requirements, Secton 5.0 the system performance criteria, and Section 6.0 quality assurance and standards. A draft of this document was issued for public comment in April 1981. Appendix A contains the DOE responses to the comments received. Appendix B is a glossary

Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations (I): catastrophic APS, APS nephropathy and heart valve lesions.

Science.gov (United States)

Cervera, R; Tektonidou, M G; Espinosa, G; Cabral, A R; González, E B; Erkan, D; Vadya, S; Adrogué, H E; Solomon, M; Zandman-Goddard, G; Shoenfeld, Y

2011-02-01

The objectives of the 'Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations' were to assess the clinical utility of the international consensus statement on classification criteria and treatment guidelines for the catastrophic APS, to identify and grade the studies that analyse the relationship between the antiphospholipid antibodies and the non-criteria APS manifestations and to present the current evidence regarding the accuracy of these non-criteria APS manifestations for the detection of patients with APS. This article summarizes the studies analysed on the catastrophic APS, APS nephropathy and heart valve lesions, and presents the recommendations elaborated by the Task Force after this analysis.

Multi-criteria analysis for municipal solid waste management in a Brazilian metropolitan area.

Science.gov (United States)

Santos, Simone Machado; Silva, Maisa Mendonça; Melo, Renata Maciel; Gavazza, Savia; Florencio, Lourdinha; Kato, Mario T

2017-10-15

The decision-making process involved in municipal solid waste management (MSWM) must consider more than just financial aspects, which makes it a difficult task in developing countries. The Recife Metropolitan Region (RMR) in the Northeast of Brazil faces a MSWM problem that has been ongoing since the 1970s, with no common solution. In order to direct short-term solutions, three MSWM alternatives were outlined for the RMR, considering the current and future situations, the time and cost involved and social/environmental criteria. A multi-criteria approach, based on the Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE), was proposed to rank these alternatives. The alternative that included two private landfill sites and seven transfer, sorting and composting stations was confirmed as the most suitable and stable option for short-term MSWM, considering the two scenarios for the criteria weights. Sensitivity analysis was also performed to support the robustness of the results. The implementation of separate collections would minimize the amount of waste buried, while maximizing the useful life of landfill sites and increasing the timeframe of the alternative. Overall, the multi-criteria analysis was helpful and accurate during the alternative selection process, considering the similarities and restrictions of each option, which can lead to difficulties during the decision-making process.

Criteria for onsite transfers of radioactive material

International Nuclear Information System (INIS)

Opperman, E.K.; Jackson, E.J.; Eggers, A.G.

1992-01-01

A general description of the requirements for making onsite transfers of radioactive material is provided in Chapter 2, along with the required sequencey of activities. Various criteria for package use are identified in Chapters 3-13. These criteria provide protection against undue radiation exposure. Package shielding, containment, and surface contamination requirements are established. Criteria for providing criticality safety are enumerated in Chapter 6. Criteria for providing hazards information are established in Chapter 13. A glossary is provided

40 CFR 258.24 - Air criteria.

Science.gov (United States)

2010-07-01

... SOLID WASTE LANDFILLS Operating Criteria § 258.24 Air criteria. (a) Owners or operators of all MSWLFs... wastes, silvicultural wastes, landclearing debris, diseased trees, or debris from emergency cleanup...

Current Approaches and Future Trends in Compost Quality Criteria for Agronomic, Environmental, and Human Health Benefits

DEFF Research Database (Denmark)

Bernal, Maria Pilar; Sommer, Sven G.; Chadwick, Dave

2017-01-01

destination, which includes agriculture, horticulture, and urban landscaping. The development of a market for compost greatly depends on the definition and adoption of quality standards. Several countries and public and private organizations have established quality standards for compost, where certain......Organic wastes are composted to stabilize organic matter, reduce the moisture content, increase the concentrations of plant nutrients, eliminate pathogens and weed seeds, develop disease suppressiveness, and reduce greenhouse gas emissions. The requirements for compost quality depend on its final...... properties are prioritized and different limits are established according to the end use. However, there is a need to harmonize such criteria at the international level. Also, if the process of composting is not managed properly, then it can result in excessive emissions of ammonia (NH3), nitrous oxide (N2O...

Prevalence of type 2 diabetes mellitus and other abnormalities of carbohydrate metabolism depending on diagnostic criteria

Directory of Open Access Journals (Sweden)

Alexander Vasil'evich Dreval'

2010-03-01

Full Text Available Aim. To assess current criteria for type 2 diabetes mellitus. Materials and methods. This screening study involving 2,368 residents of two municipal districts of the Moscow region was designed to elucidate differencesin the prevalence of abnormalities of carbohydrate metabolism depending on diagnostic criteria (WHO and ADA. Results. The prevalence of early disorders of carbohydrate metabolism and DM2 among the adult population of Moscow region is 17,1 and 7,2 respectivelyusing WHO criteria and 40,0 and 5,9% by ADA criteria. Conclusion. Refusal to undergo OGTT during screening decreases detectability of early metabolic disorders by 28,8 and 6,1% using WHO and ADAcriteria respectively. When screening is aimed to diagnose DM2 alone, OGTT can be omitted in subjects with fasting plasma glucose level below4,7 mmol/l. If it is aimed to diagnose both DM2 and impaired glucose tolerance, OGTT is not needed in subjects with fasting plasma glucose levelbelow 4,2 mmol/l. The use of ?combined? diagnostic criteria (i.e. OGTT according to ADA, but not WHO significantly increases the prevalence ofmetabolic disorders from 24,9 to 48,8%.

Criteria voor het beoordelen van tentamenuitwerkingen in het vak Programmeren [Assessment Criteria in Computer Programming Courses

NARCIS (Netherlands)

van den Berg, Klaas; van Diepen, N.M.; van Dijk, H.W.; Koppelman, Hermannus; Moerkerke, G.; Roossink, H.J.

Bij het beoordelen is het belangrijk te weten welke criteria gehanteerd moeten worden. Met behulp van een vragenlijstonderzoek onder de docenten is een beperkt aantal criteria geselecteerd die gehanteerd moeten worden bij de cursus Inleiding in het Programmeren.

Research progress on criteria for discontinuation of EGFR inhibitor therapy

Directory of Open Access Journals (Sweden)

Zhuang HQ

2012-10-01

Full Text Available Hong-qing Zhuang, Zhi-yong Yuan, Jun Wang, Ping Wang, Lu-jun Zhao, Bai-lin ZhangDepartment of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Tianjin, People's Republic of ChinaAbstract: The clinical success of the epidermal growth factor receptor (EGFR tyrosine kinase inhibitors (TKI as therapeutic agents has prompted great interest in their further development and clinical testing for a wide variety of malignancies. However, most studies have focused on the efficacy of TKI, and few studies have been done on the criteria for their discontinuation. The current standard for drug discontinuation is “until progression”, based on change in tumor size. However, tumor size is not related to the gene expression which determines the efficacy of TKI in the final analysis, and it is also difficult to make a thorough and correct prediction based on tumor size when the TKI is discontinued. Nevertheless, clinical evaluation of the criteria for TKI discontinuation is still in its early days. Some promising findings have started to emerge. With the improving knowledge of EGFR and its inhibitors, it is expected that the criteria for discontinuation of EGFR inhibitor therapy will become clearer.Keywords: epidermal growth factor receptor, drug discontinuation, acquired drug-resistance

State-wide performance criteria for international safeguards

International Nuclear Information System (INIS)

Budlong-Sylvester, K.W.; Pilat, Joseph F.; Stanbro, W.D.

2001-01-01

Traditionally, the International Atomic Energy Agency (IAEA) has relied upon prescriptive criteria to guide safeguards implementation. The prospect of replacing prescriptive safeguards criteria with more flexible performance criteria would constitute a structural change in safeguards and raises several important questions. Performance criteria imply that while safeguards goals will be fixed, the means of attaining those goals will not be explicitly prescribed. What would the performance objectives be under such a system? How would they be formulated? How would performance be linked to higher level safeguards objectives? How would safeguards performance be measured State-wide? The implementation of safeguards under performance criteria would also signal a dramatic change in the manner the Agency does business. A higher degree of flexibility could, in principle, produce greater effectiveness and efficiency, but would come with a need for increased Agency responsibility in practice. To the extent that reliance on prescriptive criteria decreases, the burden of justifying actions and ensuring their transparency will rise. Would there need to be limits to safeguards implementation? What would be the basis for setting such limits? This paper addresses these and other issues and questions relating to both the formulation and the implementation of performance-based criteria.

ACR Appropriateness Criteria® Routine Chest Radiography.

Science.gov (United States)

McComb, Barbara L; Chung, Jonathan H; Crabtree, Traves D; Heitkamp, Darel E; Iannettoni, Mark D; Jokerst, Clinton; Saleh, Anthony G; Shah, Rakesh D; Steiner, Robert M; Mohammed, Tan-Lucien H; Ravenel, James G

2016-03-01

Chest radiographs are sometimes taken before surgeries and interventional procedures on hospital admissions and outpatients. This manuscript summarizes the American College of Radiology review of the literature and recommendations on routinely performed chest radiographies in these settings. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 3 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment.

Accident analysis and DOE criteria

International Nuclear Information System (INIS)

Graf, J.M.; Elder, J.C.

1982-01-01

In analyzing the radiological consequences of major accidents at DOE facilities one finds that many facilities fall so far below the limits of DOE Order 6430 that compliance is easily demonstrated by simple analysis. For those cases where the amount of radioactive material and the dispersive energy available are enough for accident consequences to approach the limits, the models and assumptions used become critical. In some cases the models themselves are the difference between meeting the criteria or not meeting them. Further, in one case, we found that not only did the selection of models determine compliance but the selection of applicable criteria from different chapters of Order 6430 also made the difference. DOE has recognized the problem of different criteria in different chapters applying to one facility, and has proceeded to make changes for the sake of consistency. We have proposed to outline the specific steps needed in an accident analysis and suggest appropriate models, parameters, and assumptions. As a result we feed DOE siting and design criteria will be more fairly and consistently applied

Final report on a study of coherence in acceptability criteria for the technical aspects of risks associated with potentially hazardous installations

International Nuclear Information System (INIS)

Chicken, J.C.

1988-01-01

This report describes the results of the study that was made, under Contract No ECI-1390-B7221-85D, for the European Atomic Energy Community. The aim of the study was to examine and assess the feasibility of developing coherent and uniform criteria for judging the acceptability of the technical aspects of the risks associated with potentially hazardous installations. The report is arranged in five main parts. First the nature of hazardous installations is considered and this provides the basis for examination of the currently-used technical risk acceptability criteria. Next, the possible forms of criteria are explored and then universally consistent partial and overall technical risk acceptability criteria are proposed. Following this the implications of using the criteria proposed at the design, regulatory and operating levels are examined. Then, by testing the criteria against some real decisions, the practical problems of using the proposed criteria are explored. This leads to consideration of possible alternatives to the proposed criteria. Finally the conclusions that appear to be justified are summarized and the need for further work is identified

Improved Prioritization Criteria for Road Infrastructure Projects

Directory of Open Access Journals (Sweden)

Ionescu Heroiu Marcel

2016-12-01

Full Text Available This report’s main aim is to propose a methodology for assessing state-budget-funded projects based on a rigorous selection model, including clear and effective prioritization criteria. This report first argues that project prioritization and selection should be optimized against four dimensions: absorption, impact, legitimacy, and capacity. Second, it provides a diagnostic of the National Program for Local Development (PNDL, managed by the Ministry of Regional Development and Public Administration (MRDPA, as the most significant source of state-budget funding for local infrastructure projects. The PNDL’s current design and implementation leaves room for improvement, as reflected by the lack of strategic direction in allocating funds and the continued rise in the number of projects that get started without a feasible timeline for their completion. Further, this report makes recommendations for improvement of project evaluation and selection procedures for local infrastructure development projects, with a special focus on prioritization criteria and viable funding sources for each type of investment. The practical purpose is to enhance the efficiency and effectiveness of proposed investments, maximizing impact in the context of inherently limited available financial resources. A complementary focus is on opportunities for harmonizing and better coordinating investments across various sources of funding, in the context of nearly EUR 40 billion available to Romania from the EU for the 2014-2020 programming period.

Research across the disciplines: a road map for quality criteria in empirical ethics research.

Science.gov (United States)

Mertz, Marcel; Inthorn, Julia; Renz, Günter; Rothenberger, Lillian Geza; Salloch, Sabine; Schildmann, Jan; Wöhlke, Sabine; Schicktanz, Silke

2014-03-01

Research in the field of Empirical Ethics (EE) uses a broad variety of empirical methodologies, such as surveys, interviews and observation, developed in disciplines such as sociology, anthropology, and psychology. Whereas these empirical disciplines see themselves as purely descriptive, EE also aims at normative reflection. Currently there is literature about the quality of empirical research in ethics, but little or no reflection on specific methodological aspects that must be considered when conducting interdisciplinary empirical ethics. Furthermore, poor methodology in an EE study results in misleading ethical analyses, evaluations or recommendations. This not only deprives the study of scientific and social value, but also risks ethical misjudgement. While empirical and normative-ethical research projects have quality criteria in their own right, we focus on the specific quality criteria for EE research. We develop a tentative list of quality criteria--a "road map"--tailored to interdisciplinary research in EE, to guide assessments of research quality. These quality criteria fall into the categories of primary research question, theoretical framework and methods, relevance, interdisciplinary research practice and research ethics and scientific ethos. EE research is an important and innovative development in bioethics. However, a lack of standards has led to concerns about and even rejection of EE by various scholars. Our suggested orientation list of criteria, presented in the form of reflective questions, cannot be considered definitive, but serves as a tool to provoke systematic reflection during the planning and composition of an EE research study. These criteria need to be tested in different EE research settings and further refined.

Development of small reactor safety criteria in Canada

International Nuclear Information System (INIS)

Ernst, P.C.; French, P.M.; Axford, D.J.; Snell, V.G.

1990-01-01

A number of new small reactor designs have been proposed in Canada over the last several years and some have reached the stage where licensing discussions have been initiated with the Atomic Energy Control Board (AECB). An inter-organizational Small Reactor Criteria (SRC) working group was formed in 1988 to propose safety and licensing criteria for these small reactors. Two levels of criteria are proposed. The first level forms a safety philosophy and the second is a set of criteria for specific reactor applications. The safety philosophy consists of three basic safety objectives together with evaluation criteria, and fourteen fundamental principles measured by specific criteria, which must be implemented to meet the safety objectives. Two of the fourteen principles are prime: defence in depth, and safety culture; the other twelve principles can be seen as deriving from them. A benefit of this approach is that the concepts of defence in depth and safety culture become well-defined. The objectives and principles are presented in the paper and their criteria are summarized. The second level of criteria, under development, will form a safety application set and will provide small reactor criteria in a number of general areas, such as regulatory process and safety assessment, as well as for specific reactor life-cycle activities, from siting through to decommissioning. The criteria are largely deterministic. However, the frequencies and consequences of postulated accidents are assessed against numerical criteria to assist in judging the acceptability of plant design, operation, and proposed siting. All criteria proposed are designed to be testable in some evidentiary fashion, readily enabling an assessment of compliance for a given proposal

Role of the magnetospheric and ionospheric currents in the generation of the equatorial scintillations during geomagnetic storms

Directory of Open Access Journals (Sweden)

L. Z. Biktash

2004-09-01

Full Text Available The equatorial ionosphere parameters, K_p, D_st, AU and AL indices characterized contribution of different magnetospheric and ionospheric currents to the H-component of geomagnetic field are examined to test the geomagnetic activity effect on the generation of ionospheric irregularities producing VLF scintillations. According to the results of the current statistical studies, one can predict near 70% of scintillations from Aarons' criteria using the D_st index, which mainly depicts the magnetospheric ring current field. To amplify Aarons' criteria or to propose new criteria for predicting scintillation characteristics is the question. In the present phase of the experimental investigations of electron density irregularities in the ionosphere new ways are opened up because observations in the interaction between the solar wind - magnetosphere - ionosphere during magnetic storms have progressed greatly. According to present view, the intensity of the electric fields and currents at the polar regions, as well as the magnetospheric ring current intensity, are strongly dependent on the variations of the interplanetary magnetic field. The magnetospheric ring current cannot directly penetrate the equatorial ionosphere and because of this difficulties emerge in explaining its relation to scintillation activity. On the other hand, the equatorial scintillations can be observed in the absence of the magnetospheric ring current. It is shown that in addition to Aarons' criteria for the prediction of the ionospheric scintillations, models can be used to explain the relationship between the equatorial ionospheric parameters, h'F, foF2, and the equatorial geomagnetic variations with the polar ionosphere currents and the solar wind.

Assessing impact of differential symptom functioning on post-traumatic stress disorder (PTSD) diagnosis.

Science.gov (United States)

He, Qiwei; Glas, Cees A W; Veldkamp, Bernard P

2014-06-01

This article explores the generalizability of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnostic criteria for post-traumatic stress disorder (PTSD) to various subpopulations. Besides identifying the differential symptom functioning (also referred to as differential item functioning [DIF]) related to various background variables such as gender, marital status and educational level, this study emphasizes the importance of evaluating the impact of DIF on population inferences as made in health surveys and clinical trials, and on the diagnosis of individual patients. Using a sample from the National Comorbidity Study-Replication (NCS-R), four symptoms for gender, one symptom for marital status, and three symptoms for educational level were significantly flagged as DIF, but their impact on diagnosis was fairly small. We conclude that the DSM-IV diagnostic criteria for PTSD do not produce substantially biased results in the investigated subpopulations, and there should be few reservations regarding their use. Further, although the impact of DIF (i.e. the influence of differential symptom functioning on diagnostic results) was found to be quite small in the current study, we recommend that diagnosticians always perform a DIF analysis of various subpopulations using the methodology presented here to ensure the diagnostic criteria is valid in their own studies. Copyright © 2014 John Wiley & Sons, Ltd.

Review Article: Multi-criteria decision making for flood risk management: a survey of the current state-of-the-art

Science.gov (United States)

de Brito, M. M.; Evers, M.

2015-11-01

This paper provides a review of Multi-Criteria Decision Making (MCDM) applications to flood risk management, seeking to highlight trends and identify research gaps. Totally, 128 peer-reviewed papers published from 1995 to June 2015 were systematically analysed and classified into the following application areas: (1) ranking of alternatives for flood mitigation, (2) reservoir flood control, (3) susceptibility, (4) hazard, (5) vulnerability, (6) risk, (7) coping capacity, and (8) emergency management. Additionally, the articles were categorized based on the publication year, MCDM method, whether they were or were not carried out in a participatory process, and if uncertainty and sensitivity analysis were performed. Results showed that the number of flood MCDM publications has exponentially grown during this period, with over 82 % of all papers published since 2009. The Analytical Hierarchy Process (AHP) was the most popular technique, followed by Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS), and Simple Additive Weighting (SAW). Although there is greater interest on MCDM, uncertainty analysis remains an issue and is seldom applied in flood-related studies. In addition, participation of multiple stakeholders has been generally fragmented, focusing on particular stages of the decision-making process, especially on the definition of criteria weights. Based on the survey, some suggestions for further investigation are provided.

MDS clinical diagnostic criteria for Parkinson's disease in China.

Science.gov (United States)

Li, Jun; Jin, Miao; Wang, Li; Qin, Bin; Wang, Kang

2017-03-01

The Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease (MDS-PD Criteria) was introduced by the Movement Disorder Society in 2015 for research purposes. However, its use for clinical diagnosis of Parkinson disease still needs further revision. This study compares the UK-Criteria versus MDS-PD Criteria in the clinical diagnosis of Parkinson disease referred to the China-Japan Friendship Hospital of Beijing, China. To compare the MDS-PD Criteria with the UK-Criteria and discuss the feasibility of the clinical application of MDS-PD Criteria as a general guide to clinical diagnosis of PD in Chinese PD patients. 150 patients of neurology clinic of China-Japan Friendship Hospital of Beijing were recruited in our research. They were divided into three groups: UK-Criteria group, MDS-PD Criteria group and a combined group of UK and MDS-PD Criteria. Clinical history was collected while physical and auxiliary examinations were done by a trained neurologist according to the corresponding criteria. An interrater reliability analysis using the Kappa statistic claimed substantial agreement (κ = 0.626) between the MDS-PD Criteria and the UK-Criteria. The differences between the diagnostic results of these two criteria were statistically significant by paired Chi-square test (p = 0.000). It was found that levodopa-induced dyskinesia had a good positive predictive value, while early bulbar impairment and inspiratory dysfunction presented a negative predictive value. The MDS-PD Criteria emphasize the importance of non-motor symptoms, keeping the motor symptoms as the core for the clinical diagnosis of PD, and establish categories of diagnosis features and levels of certainty which are more complete and organized to be used and replicated by non specialized physicians to evaluated patients with Parkinsonism. The higher sensitivity of MDS-PD Criteria compared with UK-Criteria is worth being widely used in clinical work.

Carotid Consensus Panel duplex criteria can replace modified University of Washington criteria without affecting accuracy.

Science.gov (United States)

Kim, Ann H; Augustin, Gener; Shevitz, Andrew; Kim, Hannah; Trivonovich, Michael R; Powell, Alexis R; Kumins, Norman; Tarr, Robert; Kashyap, Vikram S

2018-04-01

The decision to intervene for internal carotid stenosis often depends on the degree of stenosis seen on duplex ultrasound (US). The aim of this study is to compare the diagnostic accuracy of two criteria: modified University of Washington (UW) and 2003 Carotid Consensus Panel (CCP). All patients undergoing US in an accredited (IAC) vascular laboratory from January 2010 to June 2015 were reviewed ( n=18,772 US exams). Patients receiving a neck computed tomography angiography (CTA) within 6 months of the US were included in the study ( n=254). The degree of stenosis was determined by UW/CCP criteria and confirmed on CTA images using North American Symptomatic Carotid Endarterectomy Trial (NASCET)/European Carotid Surgery Trial (ECST) schema. Kappa analysis with 95% confidence intervals (CIs) were utilized to determine duplex-CTA agreement. A total of 417 carotid arteries from 221 patients were assessed in this study. The modified UW criteria accurately classified 266 (63.9%, kappa = 0.321, 95% CI 0.255 to 0.386) cases according to NASCET-derived measurements. The sensitivity, specificity, and accuracy at ≥ 60% stenosis were 65.7%, 81.3%, and 81.9%. The CCP criteria resulted in 296 (70.9%) accurate diagnoses (kappa = 0.359, 95% CI 0.280 to 0.437). At ≥ 70% stenosis, the sensitivity, specificity and accuracy were 38.8%, 91.6%, and 87.1% for NASCET. Comparison of the duplex results to ECST-derived CTA measurements revealed a similar trend (UW 53.1%, κ = 0.301 vs CCP 62.1%, κ = 0.315). The CCP criteria demonstrate a higher concordance rate with measurements taken from CTAs. The CCP criteria may be more sensitive in classifying clinically significant degrees of stenosis without a loss in diagnostic accuracy.

Assessing Professionalism: A Theoretical Framework for Defining Clinical Rotation Assessment Criteria.

Science.gov (United States)

Armitage-Chan, Elizabeth

Although widely accepted as an important graduate competence, professionalism is a challenging outcome to define and assess. Clinical rotations provide an excellent opportunity to develop student professionalism through the use of experiential learning and effective feedback, but without appropriate theoretical frameworks, clinical teachers may find it difficult to identify appropriate learning outcomes. The adage "I know it when I see it" is unhelpful in providing feedback and guidance for student improvement, and criteria that are more specifically defined would help students direct their own development. This study sought first to identify how clinical faculty in one institution currently assess professionalism, using retrospective analysis of material obtained in undergraduate teaching and faculty development sessions. Subsequently, a faculty workshop was held in which a round-table type discussion sought to develop these ideas and identify how professionalism assessment could be improved. The output of this session was a theoretical framework for teaching and assessing professionalism, providing example assessment criteria and ideas for clinical teaching. This includes categories such as client and colleague interaction, respect and trust, recognition of limitations, and understanding of different professional identities. Each category includes detailed descriptions of the knowledge, skills, and behaviors expected of students in these areas. The criteria were determined by engaging faculty in the development of the framework, and therefore they should represent a focused development of criteria already used to assess professionalism, and not a novel and unfamiliar set of assessment guidelines. The faculty-led nature of this framework is expected to facilitate implementation in clinical teaching.

GIS-based Multi-Criteria Analysis of Wind Farm Development

DEFF Research Database (Denmark)

Hansen, Henning Sten

2005-01-01

Due to the negative impact on the environment of traditional powergenerating methods, especially coal and oil-fired power stations wind power has increased in popularity. Achieving the goal set by the EU due to the implementation of the Kyoto protocol will require further expansion, and in order...... to facilitate this process around the Baltic Sea. A project – Wind Energy in the Baltic Sea Region - financed by EU / INTERREG III B was initiated in order to develop methods and tools to support spatial planning in relation to wind energy. The aim of the current study is to develop multi-criteria evaluations...

24 CFR 1003.400 - Criteria for funding.

Science.gov (United States)

2010-04-01

... tribal or Federal funding sources cannot be made available to alleviate the threat. (c) HUD will... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Criteria for funding. 1003.400... Grants § 1003.400 Criteria for funding. The following criteria apply to requests for assistance under...

Design Criteria for Achieving Acceptable Indoor Radon Concentration

DEFF Research Database (Denmark)

Rasmussen, Torben Valdbjørn

2016-01-01

Design criteria for achieving an acceptable indoor radon concentration are presented in this paper. The paper suggests three design criteria. These criteria have to be considered at the early stage of the building design phase to meet the latest recommendations from the World Health Organization...... in most countries. The three design criteria are; first, establishing a radon barrier facing the ground; second, lowering the air pressure in the lower zone of the slab on ground facing downwards; third, diluting the indoor air with outdoor air. The first two criteria can prevent radon from infiltrating...... from the ground, and the third criteria can dilute the indoor air. By combining these three criteria, the indoor radon concentration can be lowered achieving an acceptable level. In addition, a cheap and reliable method for measuring the radon concentration in the indoor air is described. The provision...